</head> <body>Wang et al. (2002) have shown that EGFR signalling from endosomes leads to cell survival. PMID: 19615955</body> </html> </notes> <label text="Late Endosomes"> <bbox w="75.0" h="10.0" x="870.5" y="929.5"/> </label> <bbox w="704.0" h="534.0" x="886.0" y="2197.0"/> </glyph> <glyph class="compartment" id="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <label text="Nucleus"> <bbox w="40.0" h="10.0" x="118.0" y="1884.5"/> </label> <bbox w="4114.0" h="590.0" x="109.0" y="2844.0"/> </glyph> <glyph class="compartment" id="mpk1_mpk1_c5_mpk1_mpk1_ca5"> <label text="Golgi Apparatus"> <bbox w="80.0" h="10.0" x="135.0" y="844.5"/> </label> <bbox w="423.0" h="557.0" x="150.0" y="2106.0"/> </glyph> <glyph class="compartment" id="mpk1_mpk1_c6_mpk1_mpk1_ca6"> <label text="Endoplasmic Reticulum"> <bbox w="110.0" h="10.0" x="112.0" y="661.5"/> </label> <bbox w="195.0" h="120.0" x="147.0" y="1926.0"/> </glyph> <glyph class="compartment" id="mpk1_mpk1_c7_mpk1_mpk1_ca7"> <label text="Mitochondria"> <bbox w="65.0" h="10.0" x="1341.0" y="589.5"/> </label> <bbox w="360.0" h="300.0" x="1117.0" y="1847.0"/> </glyph> <glyph class="compartment" id="mpk1_mpk1_c9_mpk1_mpk1_ca9"> <label text="Early Endosomes"> <bbox w="80.0" h="10.0" x="2048.5" y="793.5"/> </label> <bbox w="666.0" h="215.0" x="2066.0" y="2056.0"/> </glyph> <glyph class="compartment" id="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <label text="Cytoplasm"> <bbox w="50.0" h="10.0" x="85.5" y="565.5"/> </label> <bbox w="4170.0" h="1745.0" x="84.0" y="1780.0"/> </glyph> <glyph class="compartment" id="mpk1_mpk1_c11_mpk1_mpk1_ca11"> <label text="Extracellular space"> <bbox w="100.0" h="10.0" x="141.5" y="2267.5"/> </label> <bbox w="4232.0" h="2304.0" x="60.0" y="1280.0"/> </glyph> <glyph class="compartment" id="akt1_akt1_c2_akt1_akt1_ca2"> <label text="Nucleus"> <bbox w="40.0" h="10.0" x="703.5" y="1428.0"/> </label> <bbox w="614.0" h="485.0" x="4885.0" y="1029.0"/> </glyph> <glyph class="compartment" id="akt1_akt1_c6_akt1_akt1_ca6"> <label text="Endosome"> <bbox w="45.0" h="10.0" x="2233.0" y="562.5"/> </label> <bbox w="335.0" h="502.0" x="6469.0" y="139.0"/> </glyph> <glyph class="compartment" id="akt1_akt1_c7_akt1_akt1_ca7"> <label text="Lipid Raft"> <bbox w="55.0" h="10.0" x="1264.5" y="512.5"/> </label> <bbox w="1272.0" h="477.0" x="4650.0" y="121.0"/> </glyph> <glyph class="compartment" id="akt1_akt1_c3_akt1_akt1_ca3"> <label text="Endosome Membrane"> <bbox w="90.0" h="10.0" x="1825.5" y="1378.5"/> </label> <bbox w="689.0" h="339.0" x="6005.0" y="1138.0"/> </glyph> <glyph class="compartment" id="akt1_akt1_c5_akt1_akt1_ca5"> <label text="Mitochondria"> <bbox w="65.0" h="10.0" x="2176.5" y="690.5"/> </label> <bbox w="399.0" h="452.0" x="6396.0" y="678.0"/> </glyph> <glyph class="compartment" id="akt1_akt1_c1_akt1_akt1_ca1"> <label text="Cytoplasm"> <bbox w="50.0" h="10.0" x="967.5" y="878.0"/> </label> <bbox w="2496.0" h="2445.0" x="4384.0" y="93.0"/> </glyph> <glyph class="compartment" id="akt1_akt1_c4_akt1_akt1_ca4" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <label text="Membrane Lysosome"> <bbox w="90.0" h="10.0" x="2014.0" y="2122.5"/> </label> <bbox w="1015.0" h="693.0" x="5816.0" y="1561.0"/> </glyph> <glyph class="compartment" id="akt1_akt1_c8_akt1_akt1_ca8"> <label text="Extracellular space"> <bbox w="100.0" h="10.0" x="878.0" y="52.5"/> </label> <bbox w="2500.0" h="2500.0" x="4382.0" y="40.0"/> </glyph> <glyph class="compartment" id="akt1_akt2_c2_akt1_akt2_ca2"> <label text="Nucleus"> <bbox w="40.0" h="10.0" x="1120.5" y="2915.5"/> </label> <bbox w="1981.0" h="1703.0" x="4655.0" y="2903.0"/> </glyph> <glyph class="compartment" id="akt1_akt2_c1_akt1_akt2_ca1"> <label text="Cytoplasm"> <bbox w="50.0" h="10.0" x="1322.5" y="2635.5"/> </label> <bbox w="2499.0" h="2454.0" x="4382.0" y="2623.0"/> </glyph> <glyph class="compartment" id="akt1_akt2_c3_akt1_akt2_ca3"> <label text="Extracellular space"> <bbox w="100.0" h="10.0" x="755.0" y="2592.5"/> </label> <bbox w="2500.0" h="2500.0" x="4382.0" y="2580.0"/> </glyph> <glyph class="compartment" id="wnc1_wnc1_c2_wnc1_wnc1_ca2"> <label text="Nucleus"> <bbox w="40.0" h="10.0" x="1168.5" y="964.5"/> </label> <bbox w="717.0" h="251.0" x="8012.0" y="830.0"/> </glyph> <glyph class="compartment" id="wnc1_wnc1_c5_wnc1_wnc1_ca6"> <label text="COPII vesicle"> <bbox w="70.0" h="10.0" x="1461.5" y="1170.5"/> </label> <bbox w="173.0" h="175.0" x="8378.0" y="1112.0"/> </glyph> <glyph class="compartment" id="wnc1_wnc1_c7_wnc1_wnc1_ca8"> <label text="Endosome"> <bbox w="45.0" h="10.0" x="1279.0" y="2330.5"/> </label> <bbox w="901.0" h="261.0" x="7630.0" y="2264.0"/> </glyph> <glyph class="compartment" id="wnc1_wnc1_c7_wnc1_wnc1_ca9"> <label text="Endosome"> <bbox w="45.0" h="10.0" x="1210.5" y="1864.5"/> </label> <bbox w="697.0" h="247.0" x="7839.0" y="1767.0"/> </glyph> <glyph class="compartment" id="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <label text="Cytoplasm"> <bbox w="50.0" h="10.0" x="1451.5" y="2349.5"/> </label> <bbox w="2365.0" h="2451.0" x="7199.0" y="297.0"/> </glyph> <glyph class="compartment" id="wnc1_wnc1_c3_wnc1_wnc1_ca3" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <label text="Endoplasmic Reticulum"> <bbox w="110.0" h="10.0" x="513.5" y="961.5"/> </label> <bbox w="350.0" h="144.0" x="7292.0" y="949.0"/> </glyph> <glyph class="compartment" id="wnc1_wnc1_c3_wnc1_wnc1_ca5" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <label text="Endoplasmic Reticulum"> <bbox w="110.0" h="10.0" x="1061.0" y="1182.5"/> </label> <bbox w="236.0" h="190.0" x="8008.0" y="1109.0"/> </glyph> <glyph class="compartment" id="wnc1_wnc1_c8_wnc1_wnc1_ca10"> <label text="Extracellular space"> <bbox w="100.0" h="10.0" x="77.0" y="92.5"/> </label> <bbox w="2650.0" h="2700.0" x="7012.0" y="80.0"/> </glyph> <glyph class="compartment" id="wnc1_wnc2_c4_wnc1_wnc2_ca4"> <label text="Nucleus"> <bbox w="40.0" h="10.0" x="3801.0" y="1914.5"/> </label> <bbox w="1005.0" h="567.0" x="10704.0" y="1664.0"/> </glyph> <glyph class="compartment" id="wnc1_wnc2_c3_wnc1_wnc2_ca3"> <label text="Mitochondria"> <bbox w="65.0" h="10.0" x="2967.5" y="1216.5"/> </label> <bbox w="625.0" h="318.0" x="9885.0" y="1204.0"/> </glyph> <glyph class="compartment" id="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <label text="Cytoplasm"> <bbox w="50.0" h="10.0" x="2910.5" y="832.5"/> </label> <bbox w="2081.0" h="2202.0" x="9821.0" y="451.0"/> </glyph> <glyph class="compartment" id="wnc1_wnc2_c5_wnc1_wnc2_ca5"> <label text="Neighbouring Cell"> <bbox w="90.0" h="10.0" x="4270.5" y="297.5"/> </label> <bbox w="739.0" h="75.0" x="11202.0" y="285.0"/> </glyph> <glyph class="compartment" id="wnc1_wnc2_c6_wnc1_wnc2_ca6"> <label text="Extracellular space"> <bbox w="100.0" h="10.0" x="2753.0" y="292.5"/> </label> <bbox w="2500.0" h="2500.0" x="9688.0" y="280.0"/> </glyph> <glyph class="compartment" id="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <label text="Nucleus"> <bbox w="40.0" h="10.0" x="1256.0" y="3143.5"/> </label> <bbox w="1773.0" h="1823.0" x="7555.0" y="3131.0"/> </glyph> <glyph class="compartment" id="wnc1_wnc3_c1_wnc1_wnc3_ca1"> <label text="Cytoplasm"> <bbox w="50.0" h="10.0" x="1240.0" y="2904.5"/> </label> <bbox w="2294.0" h="2307.0" x="7286.0" y="2892.0"/> </glyph> <glyph class="compartment" id="wnc1_wnc3_c3_wnc1_wnc3_ca3"> <label text="Extracellular space"> <bbox w="100.0" h="10.0" x="227.0" y="2808.5"/> </label> <bbox w="2500.0" h="2500.0" x="7162.0" y="2796.0"/> </glyph> <glyph class="compartment" id="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <label text="Nucleus"> <bbox w="40.0" h="10.0" x="3791.0" y="3954.5"/> </label> <bbox w="1196.0" h="920.0" x="10694.0" y="3942.0"/> </glyph> <glyph class="compartment" id="wnc1_wnc4_c3_wnc1_wnc4_ca3"> <label text="Protrusion"> <bbox w="55.0" h="10.0" x="4152.5" y="2938.5"/> </label> <bbox w="561.0" h="317.0" x="11062.0" y="2926.0"/> </glyph> <glyph class="compartment" id="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <label text="Cytoplasm"> <bbox w="50.0" h="10.0" x="3018.5" y="3020.5"/> </label> <bbox w="2090.0" h="2112.0" x="9929.0" y="3008.0"/> </glyph> <glyph class="compartment" id="wnc1_wnc4_c4_wnc1_wnc4_ca4" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <label text="Mitochondria"> <bbox w="65.0" h="10.0" x="3782.5" y="3570.5"/> </label> <bbox w="393.0" h="343.0" x="10700.0" y="3558.0"/> </glyph> <glyph class="compartment" id="wnc1_wnc4_c5_wnc1_wnc4_ca5"> <label text="Extracellular space"> <bbox w="100.0" h="10.0" x="2753.0" y="2808.5"/> </label> <bbox w="2500.0" h="2500.0" x="9688.0" y="2796.0"/> </glyph> <glyph class="compartment" id="wca1_wca1_c1_wca1_wca1_ca1"> <label text="Cytoplasm"> <bbox w="50.0" h="10.0" x="777.5" y="2609.5"/> </label> <bbox w="2734.0" h="2669.0" x="12343.0" y="216.0"/> </glyph> <glyph class="compartment" id="wca1_wca1_c2_wca1_wca1_ca2"> <label text="Cilium"> <bbox w="35.0" h="10.0" x="807.0" y="191.5"/> </label> <bbox w="276.0" h="213.0" x="13022.0" y="65.0"/> </glyph> <glyph class="compartment" id="wca1_wca1_c3_wca1_wca1_ca3" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <label text="Nucleus"> <bbox w="40.0" h="10.0" x="727.5" y="1258.5"/> </label> <bbox w="223.0" h="210.0" x="12906.5" y="1135.0"/> </glyph> <glyph class="compartment" id="wca1_wca1_c5_wca1_wca1_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>21183076</body> </html> </notes> <label text="Endosome"> <bbox w="45.0" h="10.0" x="1953.0" y="1286.5"/> </label> <bbox w="1053.0" h="764.0" x="13818.0" y="609.0"/> </glyph> <glyph class="compartment" id="wca1_wca1_c5_wca1_wca1_ca6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>21183076</body> </html> </notes> <label text="Endosome"> <bbox w="45.0" h="10.0" x="1954.0" y="2221.5"/> </label> <bbox w="1131.0" h="756.0" x="13803.0" y="1552.0"/> </glyph> <glyph class="compartment" id="wca1_wca1_c5_wca1_wca1_ca7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>21183076</body> </html> </notes> <label text="Endosome"> <bbox w="45.0" h="10.0" x="1695.5" y="2518.5"/> </label> <bbox w="785.0" h="339.0" x="13772.0" y="2324.0"/> </glyph> <glyph class="compartment" id="wca1_wca1_c5_wca1_wca1_ca8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>21183076</body> </html> </notes> <label text="Endosome"> <bbox w="45.0" h="10.0" x="2321.5" y="2519.5"/> </label> <bbox w="233.0" h="209.0" x="14574.0" y="2397.0"/> </glyph> <glyph class="compartment" id="wca1_wca1_c5_wca1_wca1_ca9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>21183076</body> </html> </notes> <label text="Endosome"> <bbox w="45.0" h="10.0" x="2557.5" y="2515.5"/> </label> <bbox w="97.0" h="207.0" x="14844.0" y="2399.0"/> </glyph> <glyph class="compartment" id="wca1_wca1_c4_wca1_wca1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>21183076</body> </html> </notes> <label text="Vaceolae"> <bbox w="45.0" h="10.0" x="1278.5" y="351.5"/> </label> <bbox w="1515.0" h="369.0" x="13545.0" y="84.0"/> </glyph> <glyph class="compartment" id="wca1_wca1_c6_wca1_wca1_ca10" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Multivesicular bodies are required to sequester away GSK3, Axin from newly synthesised b-catenin. 21183076</body> </html> </notes> <label text="Multivesicular Body"> <bbox w="100.0" h="10.0" x="1808.5" y="2607.5"/> </label> <bbox w="1209.0" h="1198.0" x="13757.0" y="1496.0"/> </glyph> <glyph class="compartment" id="wca1_wca1_c7_wca1_wca1_ca11"> <label text="Extracellular space"> <bbox w="100.0" h="10.0" x="54.0" y="62.5"/> </label> <bbox w="3000.0" h="3000.0" x="12338.0" y="50.0"/> </glyph> <glyph class="compartment" id="wca1_wca2_c2_wca1_wca2_ca2"> <label text="Endosome"> <bbox w="45.0" h="10.0" x="3821.5" y="951.5"/> </label> <bbox w="292.0" h="168.0" x="16108.0" y="939.0"/> </glyph> <glyph class="compartment" id="wca1_wca2_c2_wca1_wca2_ca3"> <label text="Endosome"> <bbox w="45.0" h="10.0" x="3649.5" y="1341.5"/> </label> <bbox w="899.0" h="322.0" x="15936.0" y="1329.0"/> </glyph> <glyph class="compartment" id="wca1_wca2_c3_wca1_wca2_ca4"> <label text="Nucleus"> <bbox w="40.0" h="10.0" x="3667.0" y="1811.5"/> </label> <bbox w="460.0" h="174.0" x="15946.0" y="1799.0"/> </glyph> <glyph class="compartment" id="wca1_wca2_c1_wca1_wca2_ca1"> <label text="Cytoplasm"> <bbox w="50.0" h="10.0" x="3242.5" y="2463.5"/> </label> <bbox w="2167.0" h="2273.0" x="15529.0" y="777.0"/> </glyph> <glyph class="compartment" id="wca1_wca2_c5_wca1_wca2_ca6"> <label text="Extracellular space"> <bbox w="100.0" h="10.0" x="3059.0" y="562.5"/> </label> <bbox w="2500.0" h="2500.0" x="15370.0" y="550.0"/> </glyph> <glyph class="compartment" id="wca1_wca2_c4_wca1_wca2_ca5" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <label text="Early Endosome"> <bbox w="75.0" h="10.0" x="5101.5" y="1985.5"/> </label> <bbox w="164.0" h="133.0" x="17404.0" y="1973.0"/> </glyph> <glyph class="compartment" id="wca1_wca3_c2_wca1_wca3_ca2"> <label text="Nucleus"> <bbox w="40.0" h="10.0" x="1278.0" y="3598.5"/> </label> <bbox w="2008.0" h="1744.0" x="13139.0" y="3586.0"/> </glyph> <glyph class="compartment" id="wca1_wca3_c1_wca1_wca3_ca1"> <label text="Cytoplasm"> <bbox w="50.0" h="10.0" x="1189.0" y="3354.5"/> </label> <bbox w="2409.0" h="2225.0" x="12853.0" y="3342.0"/> </glyph> <glyph class="compartment" id="wca1_wca3_c3_wca1_wca3_ca3"> <label text="Extracellular space"> <bbox w="100.0" h="10.0" x="527.0" y="3094.5"/> </label> <bbox w="2500.0" h="2500.0" x="12838.0" y="3082.0"/> </glyph> <glyph class="compartment" id="wca1_wca4_c2_wca1_wca4_ca2"> <label text="Nucleus"> <bbox w="40.0" h="10.0" x="3364.0" y="3438.5"/> </label> <bbox w="1967.0" h="1872.0" x="15643.0" y="3426.0"/> </glyph> <glyph class="compartment" id="wca1_wca4_c1_wca1_wca4_ca1"> <label text="Cytoplasm"> <bbox w="50.0" h="10.0" x="3122.5" y="3133.5"/> </label> <bbox w="2392.0" h="2441.0" x="15409.0" y="3121.0"/> </glyph> <glyph class="compartment" id="wca1_wca4_c3_wca1_wca4_ca3"> <label text="Extracellular space"> <bbox w="100.0" h="10.0" x="3059.0" y="3094.5"/> </label> <bbox w="2500.0" h="2500.0" x="15370.0" y="3082.0"/> </glyph> <glyph class="compartment" id="shh1_shh1_c3_shh1_shh1_ca3"> <label text="Proteosome"> <bbox w="55.0" h="10.0" x="302.0" y="1617.5"/> </label> <bbox w="538.0" h="158.0" x="18015.0" y="1548.0"/> </glyph> <glyph class="compartment" id="shh1_shh1_c6_shh1_shh1_ca6"> <label text="Nucleus"> <bbox w="40.0" h="10.0" x="1603.5" y="2115.5"/> </label> <bbox w="734.0" h="486.0" x="19178.0" y="1716.0"/> </glyph> <glyph class="compartment" id="shh1_shh1_c7_shh1_shh1_ca7"> <label text="Endosome"> <bbox w="45.0" h="10.0" x="2269.5" y="2052.5"/> </label> <bbox w="205.0" h="247.0" x="20167.0" y="1893.0"/> </glyph> <glyph class="compartment" id="shh1_shh1_c5_shh1_shh1_ca5"> <label text="Clathrin-coated vesicle"> <bbox w="120.0" h="10.0" x="905.5" y="379.5"/> </label> <bbox w="199.0" h="270.0" x="18812.0" y="203.0"/> </glyph> <glyph class="compartment" id="shh1_shh1_c8_shh1_shh1_ca8"> <label text="Extracellular space"> <bbox w="100.0" h="10.0" x="72.5" y="62.5"/> </label> <bbox w="2500.0" h="2500.0" x="17950.0" y="50.0"/> </glyph> <glyph class="compartment" id="shh1_shh1_c4_shh1_shh1_ca4"> <label text="Primary Cilium"> <bbox w="75.0" h="10.0" x="1114.0" y="441.5"/> </label> <bbox w="1306.0" h="998.0" x="19042.0" y="83.0"/> </glyph> <glyph class="compartment" id="shh1_shh2_c2_shh1_shh2_ca2"> <label text="Nucleus"> <bbox w="40.0" h="10.0" x="1259.0" y="2950.5"/> </label> <bbox w="2059.0" h="1846.0" x="18203.0" y="2938.0"/> </glyph> <glyph class="compartment" id="shh1_shh2_c3_shh1_shh2_ca3"> <label text="Extracellular space"> <bbox w="100.0" h="10.0" x="90.5" y="2602.5"/> </label> <bbox w="2498.0" h="2260.0" x="17950.0" y="2590.0"/> </glyph> <glyph class="compartment" id="shh1_shh3_c2_shh1_shh3_ca2"> <label text="Extracellular space"> <bbox w="100.0" h="10.0" x="45.0" y="4889.5"/> </label> <bbox w="2486.0" h="980.0" x="17945.0" y="4877.0"/> </glyph> <glyph class="compartment" id="shh1_shh2_c1_shh1_shh1_ca1"> <label text="Cytosol"> <bbox w="40.0" h="10.0" x="432.5" y="2442.5"/> </label> <bbox w="2470.0" h="2392.0" x="17952.0" y="156.0"/> </glyph> <glyph class="compartment" id="shh1_shh2_c1_shh1_shh2_ca1"> <label text="Cytosol"> <bbox w="40.0" h="10.0" x="1230.5" y="2667.5"/> </label> <bbox w="2489.0" h="2197.0" x="17951.0" y="2655.0"/> </glyph> <glyph class="compartment" id="shh1_shh2_c1_shh1_shh3_ca1"> <label text="Cytosol"> <bbox w="40.0" h="10.0" x="1257.5" y="4979.5"/> </label> <bbox w="2400.0" h="857.0" x="17981.0" y="4959.0"/> </glyph> <glyph class="macromolecule" id="gf1_s14_gf1_sa30" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:PDGFA HUGO:PDGFB HUGO:PDGFC HUGO:PDGFD MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:23123598 PDGF stimulation of CAFs induces production of the prototypical pro-angiogenic inducer fibroblast growth factor (FGF)-2 in both cervical carcinomas and melanoma [11] and [85]. Interestingly, CAFs activated by PDGF-CC in melanomas also secrete the extracellular matrix protein osteopontin, the action of which is known to synergistically stimulate angiogenesis together with FGF-2 and promote autocrine VEGF-A signaling in endothelial cells PMID:15207817; PMID:19118022 PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma. Tumor fibroblasts a recruted by PDGF PMID: 24703957 PDGFs are encoded by four different genes: PDGF-A, -B, -C and -D, which are related to VEGF and belong to the ???cystine knots??? protein superfamily The two PDGF receptors, namely PDGFR?? and ??, are receptor tyrosine kinases (RTK) belonging to the so-called type III family, which also includes c-KIT, c-FMS and FLT3 (the receptors of stem cell factor, CSF1 and FLT3-ligand, respectively). They are more distantly related to the receptors of VEGF and fibroblast growth factors (FGF). PDGF ligands and receptors are proto-oncogenes that can be activated by various types of genetic alterations in cancer cells</body> </html> </notes> <label text="PDGF*"/> <bbox w="80.0" h="40.0" x="273.5" y="127.5"/> </glyph> <glyph class="macromolecule" id="gf1_s4526_gf1_sa32" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:FGF1 HUGO:FGF2 HUGO:FGF3 HUGO:FGF4 HUGO:FGF5 HUGO:FGF6 HUGO:FGF7 HUGO:FGF8 HUGO:FGF9 HUGO:FGF10 HUGO:FGF11 HUGO:FGF12 HUGO:FGF13 HUGO:FGF14 HUGO:FGF16 HUGO:FGF17 HUGO:FGF18 HUGO:FGF19 HUGO:FGF20 HUGO:FGF21 HUGO:FGF22 HUGO:FGF23 MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:25772309 Deregulation of FGF signaling pathways have been implicated in many types of human and animal cancers.</body> </html> </notes> <label text="FGF*"/> <bbox w="80.0" h="40.0" x="612.5" y="127.5"/> </glyph> <glyph class="macromolecule" id="gf1_s423_gf1_sa35" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:PGDFRA HUGO:PGDFRB MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID: 24703957 PDGFs are encoded by four different genes: PDGF-A, -B, -C and -D, which are related to VEGF and belong to the ???cystine knots??? protein superfamily The two PDGF receptors, namely PDGFR alpha and beta, are receptor tyrosine kinases (RTK) belonging to the so-called type III family, which also includes c-KIT, c-FMS and FLT3 (the receptors of stem cell factor, CSF1 and FLT3-ligand, respectively). They are more distantly related to the receptors of VEGF and fibroblast growth factors (FGF). PDGFRA binds to all PDGF isoforms except PDGF-DD, while PDGFRB is activated by PDGF-BB and -DD. PDGF ligands and receptors are proto-oncogenes that can be activated by various types of genetic alterations in cancer cells . The large protein complex recruited by phosphorylated PDGF receptors is seen as a dynamic signalosome that controls cell fate.</body> </html> </notes> <label text="PDGFR*"/> <bbox w="80.0" h="50.0" x="402.5" y="322.5"/> <glyph class="unit of information" id="_cfb9f562-7303-40b5-9d22-98a3b1098d92"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="420.0" y="317.5"/> </glyph> </glyph> <glyph class="macromolecule" id="gf1_s4554_gf1_sa37" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>HUGO:FRS2 MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:25772309 Downstream of the signaling tyrosine kinase FGFRs, intracellular signaling cascades are also tightly regulated by specialized adaptor proteins such as FGFR substrate 2?? (FRS2??) and regulators of the RAS???MAPK and PI3K???AKT pathways such as Sprouty (SPRY) proteins Identifiers_begin: fibroblast growth factor receptor substrate 2 HUGO:FRS2 HGNC:16971 ENTREZ:10818 UNIPROT:Q8WU20 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end</body> </html> </notes> <label text="FRS2"/> <bbox w="80.0" h="40.0" x="743.5" y="777.5"/> <glyph class="state variable" id="_88f497f6-47b9-45d5-a401-96eed3e320e7"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="736.0" y="792.5"/> </glyph> <glyph class="state variable" id="_e6cf9f56-a9ee-4c5a-a77e-20d0e7b8a961"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="738.5" y="792.5"/> </glyph> </glyph> <glyph class="macromolecule" id="gf1_s4547_gf1_sa38" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>HUGO:FRS2 MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:25772309 Downstream of the signaling tyrosine kinase FGFRs, intracellular signaling cascades are also tightly regulated by specialized adaptor proteins such as FGFR substrate 2?? (FRS2??) and regulators of the RAS???MAPK and PI3K???AKT pathways such as Sprouty (SPRY) proteins Identifiers_begin: fibroblast growth factor receptor substrate 2 HUGO:FRS2 HGNC:16971 ENTREZ:10818 UNIPROT:Q8WU20 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end</body> </html> </notes> <label text="FRS2"/> <bbox w="80.0" h="40.0" x="742.5" y="667.5"/> <glyph class="state variable" id="_6586a8f8-b596-4528-97c5-f6b65d3b40f2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="737.5" y="682.5"/> </glyph> <glyph class="state variable" id="_a313650d-c386-43d5-a1ec-9de79ba78ea5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="737.5" y="682.5"/> </glyph> </glyph> <glyph class="macromolecule" id="gf1_s4735_gf1_sa42" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:FGFR1 HUGO:FGFR2 HUGO:FGFR3 HUGO:FGFR4 HUGO:FGFRL1 MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:25467007 FGFRs _rew PMID:25772309 Binding of canonical FGFs to FGFR with HS (or HSPG) as a cofactor induces the formation of ternary FGF???FGFR???HS complex, which activates the FGFR intracellular tyrosine kinase domain by phosphorylation of specific tyrosine residues. The activated receptor is coupled to intracellular signaling pathways including the RAS???MAPK, PI3K???AKT, PLC??, and STAT pathways.</body> </html> </notes> <label text="FGFR*"/> <bbox w="80.0" h="50.0" x="722.5" y="322.5"/> <glyph class="unit of information" id="_5aaf00f0-642b-4d22-a4a7-f19e613fdf9c"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="740.0" y="317.5"/> </glyph> </glyph> <glyph class="macromolecule" id="gf1_s4506_gf1_sa44" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:AREG MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:20430953</body> </html> </notes> <label text="AREG"/> <bbox w="80.0" h="40.0" x="1192.5" y="127.5"/> </glyph> <glyph class="macromolecule" id="gf1_s416_gf1_sa45" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:ERBB2 HUGO:ERBB3 HUGO:ERBB4 MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:20430953 All EGF family members bind to a group of four receptor tyrosine kinases, namely ErbB-1/EGFR through -4 (also called HER1???4). Like other tyrosine kinases, each ErbB molecule comprises an extracellular domain to allow ligand binding, a single transmembrane part, and an intracellular protein tyrosine kinase domain. It is important noting that not all ErbB receptors act autonomously: ErbB-2 (also called HER2 and Neu) binds no known EGF-like ligand (56), and ErbB-3 shows no tyrosine kinase activity (40).</body> </html> </notes> <label text="ERBB*"/> <bbox w="80.0" h="50.0" x="1522.5" y="322.5"/> <glyph class="unit of information" id="_9ff62a8a-d756-4279-a344-4a8fffd382c7"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="1540.0" y="317.5"/> </glyph> </glyph> <glyph class="macromolecule" id="gf1_s102_gf1_sa46" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:EGF MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:20430953</body> </html> </notes> <label text="EGF"/> <bbox w="80.0" h="40.0" x="1482.5" y="127.5"/> </glyph> <glyph class="macromolecule" id="gf1_s415_gf1_sa48" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>HUGO:EGFR MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:20430953 All EGF family members bind to a group of four receptor tyrosine kinases, namely ErbB-1/EGFR through -4 (also called HER1???4). Like other tyrosine kinases, each ErbB molecule comprises an extracellular domain to allow ligand binding, a single transmembrane part, and an intracellular protein tyrosine kinase domain. It is important noting that not all ErbB receptors act autonomously: ErbB-2 (also called HER2 and Neu) binds no known EGF-like ligand (56), and ErbB-3 shows no tyrosine kinase activity (40). PMID:28513565 Epidermal growth factor receptor (EGFR) signaling pathways leading to G1/S cell cycle progression activated by EGF activation. Depicted are the RAS-RAF-MEK-ERK MAPK and PI3K-AKT-mTOR pathways. Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)", ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="EGFR"/> <bbox w="80.0" h="50.0" x="1462.5" y="432.5"/> <glyph class="unit of information" id="_d604d9b7-31e5-42b4-af5d-33543525e60f"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="1480.0" y="427.5"/> </glyph> </glyph> <glyph class="macromolecule" id="gf1_s4593_gf1_sa52" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:IGF2R MODULE:GROWTH_FACTORS_SIGNALING_PATHWAYS PMID:27548915 One function of IGF2R is to bind to the ligand IGF2, leading to IGF2 degradation and consequently an inhibition of the growth stimulation that results from the interaction between IGF2 and IGF1R48, 49. IGF2 is upregulated in CAFs50, suggesting that IGF2R is inhibited. Therefore, reduction in IGF2R following treatment with miR-211 or melanosomes may increase IGF2 levels, promoting its binding to IGF1R, and thus leading to hyperactivation of this pathway and increased proliferation.</body> </html> </notes> <label text="IGF2R"/> <bbox w="80.0" h="50.0" x="2172.5" y="322.5"/> <glyph class="unit of information" id="_47f9061b-afdf-4891-b13a-26f064ef6dce"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2190.0" y="317.5"/> </glyph> </glyph> <glyph class="macromolecule" id="gf1_s4508_gf1_sa53" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:IGF2 MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:24668028 IGF2 expressed by CAFs promotes tumor growth PMID:11237532 In breast cancers, both IGF-I and IGF-II are expressed in the stromal ???broblasts and expression of IGF-II in particular correlates with tumor progression</body> </html> </notes> <label text="IGF2"/> <bbox w="80.0" h="40.0" x="1922.5" y="127.5"/> </glyph> <glyph class="macromolecule" id="gf1_s4564_gf1_sa55" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:IRS1 HUGO:IRS2 MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:8621421 Grb2- and Shc-SH2 domain binding to phosphopeptides from rat IRS-1 PMID:12175651; PMID:10086337 Upon IGF-IR autophosphorylation the protein Shc is recruited to the receptor and becomes phosphorylated on tyrosine residues.36 Activated Shc then binds the adaptor Grb2 in an IRS-1-independent manner, leading to activation of the Ras-ERK pathway.36 This pathway of IGF-IR signaling has been most closely associated with cell differentiation and migration, but in some cases also can regulate the machinery of apoptosis, for example, in detachment-induced death, or anoikis, in fibroblasts.</body> </html> </notes> <label text="IRS*"/> <bbox w="80.0" h="40.0" x="1952.5" y="757.5"/> <glyph class="state variable" id="_d9a192ac-b880-42a8-8b7d-165bcab98c1c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1945.0" y="772.5"/> </glyph> </glyph> <glyph class="macromolecule" id="gf1_s4563_gf1_sa56" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:IRS1 HUGO:IRS2 MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:8621421 Grb2- and Shc-SH2 domain binding to phosphopeptides from rat IRS-1 PMID:12175651; PMID:10086337 Upon IGF-IR autophosphorylation the protein Shc is recruited to the receptor and becomes phosphorylated on tyrosine residues.36 Activated Shc then binds the adaptor Grb2 in an IRS-1-independent manner, leading to activation of the Ras-ERK pathway.36 This pathway of IGF-IR signaling has been most closely associated with cell differentiation and migration, but in some cases also can regulate the machinery of apoptosis, for example, in detachment-induced death, or anoikis, in fibroblasts.</body> </html> </notes> <label text="IRS*"/> <bbox w="80.0" h="40.0" x="1952.5" y="657.5"/> <glyph class="state variable" id="_3232804e-00af-4cfa-9661-9507592ad641"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1947.5" y="672.5"/> </glyph> </glyph> <glyph class="macromolecule" id="gf1_s4565_gf1_sa57" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:IGF1R MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:12175651; PMID:10086337 Upon IGF-IR autophosphorylation the protein Shc is recruited to the receptor and becomes phosphorylated on tyrosine residues.36 Activated Shc then binds the adaptor Grb2 in an IRS-1-independent manner, leading to activation of the Ras-ERK pathway.36 This pathway of IGF-IR signaling has been most closely associated with cell differentiation and migration, but in some cases also can regulate the machinery of apoptosis, for example, in detachment-induced death, or anoikis, in fibroblasts.</body> </html> </notes> <label text="IGF1R"/> <bbox w="80.0" h="50.0" x="1852.5" y="522.5"/> <glyph class="state variable" id="_c60490bb-1655-4f3f-9486-6e7c2924c8c2"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1845.0" y="542.5"/> </glyph> <glyph class="unit of information" id="_46b1502a-4b09-41a4-ba87-b23b663576ed"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="1870.0" y="517.5"/> </glyph> </glyph> <glyph class="macromolecule" id="gf1_s4515_gf1_sa58" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:IGF1R MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:12175651; PMID:10086337 Upon IGF-IR autophosphorylation the protein Shc is recruited to the receptor and becomes phosphorylated on tyrosine residues.36 Activated Shc then binds the adaptor Grb2 in an IRS-1-independent manner, leading to activation of the Ras-ERK pathway.36 This pathway of IGF-IR signaling has been most closely associated with cell differentiation and migration, but in some cases also can regulate the machinery of apoptosis, for example, in detachment-induced death, or anoikis, in fibroblasts.</body> </html> </notes> <label text="IGF1R"/> <bbox w="80.0" h="50.0" x="1852.5" y="322.5"/> <glyph class="state variable" id="_4138c239-7657-4c3c-93cd-418946c4e78b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1847.5" y="342.5"/> </glyph> <glyph class="unit of information" id="_8e962ec9-9569-4527-af01-6c617157efd7"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="1870.0" y="317.5"/> </glyph> </glyph> <glyph class="macromolecule" id="gf1_s4519_gf1_sa59" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:IGF1 MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID: 20388853 Upon binding by either IGF-1 or IGF-2, the IGF-1R undergoes receptor cross-linking and autophosphorylation, leading to the creation of multiple docking sites for the adaptor proteins IRS-1, IRS-2, and Shc.</body> </html> </notes> <label text="IGF1"/> <bbox w="80.0" h="40.0" x="2072.5" y="127.5"/> </glyph> <glyph class="source and sink" id="gf1_s4597_gf1_sa63" compartmentRef="gf1_c1_gf1_ca1"> <label text="csa102_degraded"/> <bbox w="30.0" h="30.0" x="2247.5" y="662.5"/> </glyph> <glyph class="macromolecule" id="gf1_s4529_gf1_sa65" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:MET MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:28475121; PMID:20303741 Upon HGF binding, Met autophosphorylation occurs on tyrosine residues Y1234 and Y1235 (numbered according to GenBank J02958) within the activation loop of the TK domain, inducing kinase activity, while phosphorylation on Y1349 and Y1356 near the carboxyl terminus forms a docking site for intracellular adapters that transmit signals downstream.6, 8 An intact docking site is required for transformation and metastasis.8 Critical signalling mediators in this pathway include Grb2, Gab1, phosphatidylinositol 3-kinase (PI3K), phospholipase C-gamma (PLC??), Shc, Src, Shp2, Ship1 and STAT3.6, 8</body> </html> </notes> <label text="MET"/> <bbox w="80.0" h="50.0" x="2372.5" y="322.5"/> <glyph class="state variable" id="_227dae45-6856-4b81-8d39-67a0069a88f5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2367.5" y="342.5"/> </glyph> <glyph class="unit of information" id="_d0961bd5-23c9-4c2b-9481-d78c3a272695"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2390.0" y="317.5"/> </glyph> </glyph> <glyph class="macromolecule" id="gf1_s4468_gf1_sa66" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:HGF MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:28475121 Hepatocyte growth factor (HGF) induces cancer cell migration and invasion.</body> </html> </notes> <label text="HGF"/> <bbox w="80.0" h="40.0" x="2462.5" y="127.5"/> </glyph> <glyph class="complex" id="gf1_s417_gf1_csa8" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>PMID:7682895; PMID:17397400 PDGF -receptor directly binds and activates PLC-gamma 1, RasGAP, P13K, and a 64 kd protein. PI3K-Akt pathway promotes microtubule stabilization in migrating fibroblasts downstream of PDGF signaling</body> </html> </notes> <label text="gf1_s417"/> <bbox w="100.0" h="130.0" x="212.5" y="492.5"/> <glyph class="macromolecule" id="gf1_s413_gf1_sa106"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:PGDFRA HUGO:PGDFRB MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID: 24703957 PDGFs are encoded by four different genes: PDGF-A, -B, -C and -D, which are related to VEGF and belong to the ???cystine knots??? protein superfamily The two PDGF receptors, namely PDGFR alpha and beta, are receptor tyrosine kinases (RTK) belonging to the so-called type III family, which also includes c-KIT, c-FMS and FLT3 (the receptors of stem cell factor, CSF1 and FLT3-ligand, respectively). They are more distantly related to the receptors of VEGF and fibroblast growth factors (FGF). PDGFRA binds to all PDGF isoforms except PDGF-DD, while PDGFRB is activated by PDGF-BB and -DD. PDGF ligands and receptors are proto-oncogenes that can be activated by various types of genetic alterations in cancer cells . The large protein complex recruited by phosphorylated PDGF receptors is seen as a dynamic signalosome that controls cell fate.</body> </html> </notes> <label text="PDGFR*"/> <bbox w="80.0" h="50.0" x="222.5" y="552.5"/> <glyph class="unit of information" id="_c4144bc4-a27b-4307-8729-50e48cab343e"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="240.0" y="547.5"/> </glyph> </glyph> <glyph class="macromolecule" id="gf1_s424_gf1_sa107"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:PDGFA HUGO:PDGFB HUGO:PDGFC HUGO:PDGFD MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:23123598 PDGF stimulation of CAFs induces production of the prototypical pro-angiogenic inducer fibroblast growth factor (FGF)-2 in both cervical carcinomas and melanoma [11] and [85]. Interestingly, CAFs activated by PDGF-CC in melanomas also secrete the extracellular matrix protein osteopontin, the action of which is known to synergistically stimulate angiogenesis together with FGF-2 and promote autocrine VEGF-A signaling in endothelial cells PMID:15207817; PMID:19118022 PDGF receptors-mediators of autocrine tumor growth and regulators of tumor vasculature and stroma. Tumor fibroblasts a recruted by PDGF PMID: 24703957 PDGFs are encoded by four different genes: PDGF-A, -B, -C and -D, which are related to VEGF and belong to the ???cystine knots??? protein superfamily The two PDGF receptors, namely PDGFR?? and ??, are receptor tyrosine kinases (RTK) belonging to the so-called type III family, which also includes c-KIT, c-FMS and FLT3 (the receptors of stem cell factor, CSF1 and FLT3-ligand, respectively). They are more distantly related to the receptors of VEGF and fibroblast growth factors (FGF). PDGF ligands and receptors are proto-oncogenes that can be activated by various types of genetic alterations in cancer cells</body> </html> </notes> <label text="PDGF*"/> <bbox w="80.0" h="40.0" x="222.5" y="507.5"/> </glyph> </glyph> <glyph class="complex" id="gf1_s419_gf1_csa10" compartmentRef="gf1_c1_gf1_ca1"> <label text="gf1_s419"/> <bbox w="100.0" h="142.5" x="1172.5" y="506.25"/> <glyph class="macromolecule" id="gf1_s421_gf1_sa110"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>HUGO:EGFR MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:20430953 All EGF family members bind to a group of four receptor tyrosine kinases, namely ErbB-1/EGFR through -4 (also called HER1???4). Like other tyrosine kinases, each ErbB molecule comprises an extracellular domain to allow ligand binding, a single transmembrane part, and an intracellular protein tyrosine kinase domain. It is important noting that not all ErbB receptors act autonomously: ErbB-2 (also called HER2 and Neu) binds no known EGF-like ligand (56), and ErbB-3 shows no tyrosine kinase activity (40). PMID:28513565 Epidermal growth factor receptor (EGFR) signaling pathways leading to G1/S cell cycle progression activated by EGF activation. Depicted are the RAS-RAF-MEK-ERK MAPK and PI3K-AKT-mTOR pathways. Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)", ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="EGFR"/> <bbox w="80.0" h="50.0" x="1182.5" y="523.75"/> <glyph class="unit of information" id="_13486e9e-383c-46e4-90bc-348f391b34f6"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="1200.0" y="518.75"/> </glyph> </glyph> <glyph class="macromolecule" id="gf1_s422_gf1_sa111"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:ERBB2 HUGO:ERBB3 HUGO:ERBB4 MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:20430953 All EGF family members bind to a group of four receptor tyrosine kinases, namely ErbB-1/EGFR through -4 (also called HER1???4). Like other tyrosine kinases, each ErbB molecule comprises an extracellular domain to allow ligand binding, a single transmembrane part, and an intracellular protein tyrosine kinase domain. It is important noting that not all ErbB receptors act autonomously: ErbB-2 (also called HER2 and Neu) binds no known EGF-like ligand (56), and ErbB-3 shows no tyrosine kinase activity (40).</body> </html> </notes> <label text="ERBB*"/> <bbox w="80.0" h="50.0" x="1182.5" y="573.75"/> <glyph class="unit of information" id="_6db49f90-8343-4e05-b0b5-bf1ecf474d7f"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="1200.0" y="568.75"/> </glyph> </glyph> </glyph> <glyph class="complex" id="gf1_s4594_gf1_csa13" compartmentRef="gf1_c1_gf1_ca1"> <label text="gf1_s4594"/> <bbox w="100.0" h="120.0" x="2102.5" y="517.5"/> <glyph class="macromolecule" id="gf1_s4807_gf1_sa116"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:IGF2R MODULE:GROWTH_FACTORS_SIGNALING_PATHWAYS PMID:27548915 One function of IGF2R is to bind to the ligand IGF2, leading to IGF2 degradation and consequently an inhibition of the growth stimulation that results from the interaction between IGF2 and IGF1R48, 49. IGF2 is upregulated in CAFs50, suggesting that IGF2R is inhibited. Therefore, reduction in IGF2R following treatment with miR-211 or melanosomes may increase IGF2 levels, promoting its binding to IGF1R, and thus leading to hyperactivation of this pathway and increased proliferation.</body> </html> </notes> <label text="IGF2R"/> <bbox w="80.0" h="50.0" x="2112.5" y="572.5"/> <glyph class="unit of information" id="_0570584b-b192-4067-8e1a-c08dddd12cc1"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2130.0" y="567.5"/> </glyph> </glyph> <glyph class="macromolecule" id="gf1_s4596_gf1_sa117"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:IGF2 MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:24668028 IGF2 expressed by CAFs promotes tumor growth PMID:11237532 In breast cancers, both IGF-I and IGF-II are expressed in the stromal ???broblasts and expression of IGF-II in particular correlates with tumor progression</body> </html> </notes> <label text="IGF2"/> <bbox w="80.0" h="40.0" x="2112.5" y="527.5"/> </glyph> </glyph> <glyph class="complex" id="gf1_s4530_gf1_csa15" compartmentRef="gf1_c1_gf1_ca1"> <label text="gf1_s4530"/> <bbox w="100.0" h="120.0" x="2452.5" y="517.5"/> <glyph class="macromolecule" id="gf1_s4825_gf1_sa120"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:HGF MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:28475121 Hepatocyte growth factor (HGF) induces cancer cell migration and invasion.</body> </html> </notes> <label text="HGF"/> <bbox w="80.0" h="40.0" x="2462.5" y="527.5"/> </glyph> <glyph class="macromolecule" id="gf1_s4826_gf1_sa121"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:MET MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:28475121; PMID:20303741 Upon HGF binding, Met autophosphorylation occurs on tyrosine residues Y1234 and Y1235 (numbered according to GenBank J02958) within the activation loop of the TK domain, inducing kinase activity, while phosphorylation on Y1349 and Y1356 near the carboxyl terminus forms a docking site for intracellular adapters that transmit signals downstream.6, 8 An intact docking site is required for transformation and metastasis.8 Critical signalling mediators in this pathway include Grb2, Gab1, phosphatidylinositol 3-kinase (PI3K), phospholipase C-gamma (PLC??), Shc, Src, Shp2, Ship1 and STAT3.6, 8</body> </html> </notes> <label text="MET"/> <bbox w="80.0" h="50.0" x="2462.5" y="572.5"/> <glyph class="state variable" id="_3021eab2-66b1-438d-9ea7-91b15b2d2dd2"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2455.0" y="592.5"/> </glyph> <glyph class="unit of information" id="_555cd1e1-402e-4b39-8601-4ccbf260dcca"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2480.0" y="567.5"/> </glyph> </glyph> </glyph> <glyph class="macromolecule" id="gf1_s1_gf1_sa130" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:TGFA MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:20430953</body> </html> </notes> <label text="TGFA"/> <bbox w="80.0" h="40.0" x="1102.5" y="127.5"/> </glyph> <glyph class="macromolecule" id="gf1_s2_gf1_sa131" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:NRG1 HUGO:NRG2 HUGO:NRG3 HUGO:NRG4 MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:20430953</body> </html> </notes> <label text="NRG*"/> <bbox w="80.0" h="40.0" x="1282.5" y="127.5"/> </glyph> <glyph class="macromolecule" id="gf1_s3_gf1_sa132" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:BTC MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:20430953</body> </html> </notes> <label text="BTC"/> <bbox w="80.0" h="40.0" x="1002.5" y="127.5"/> </glyph> <glyph class="macromolecule" id="gf1_s4_gf1_sa133" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:EREG MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:20430953</body> </html> </notes> <label text="EREG"/> <bbox w="80.0" h="40.0" x="1612.5" y="127.5"/> </glyph> <glyph class="macromolecule" id="gf1_s5_gf1_sa134" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:HBEGF MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:20430953</body> </html> </notes> <label text="HBEGF"/> <bbox w="80.0" h="40.0" x="902.5" y="127.5"/> </glyph> <glyph class="macromolecule" id="gf1_s6_gf1_sa135" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:EPGN MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:20430953</body> </html> </notes> <label text="EPGN"/> <bbox w="80.0" h="40.0" x="1382.5" y="127.5"/> </glyph> <glyph class="macromolecule" id="gf1_s5191_gf1_sa136" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:VEGFA HUGO:VEGFB HUGO:VEGFC HUGO:VEGFD HUGO:PGF MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:16951216 Vascular Endothelial Growth Factor Signaling Pathways</body> </html> </notes> <label text="VEGF*"/> <bbox w="80.0" h="40.0" x="3262.5" y="127.5"/> </glyph> <glyph class="macromolecule" id="gf1_s3913_gf1_sa138" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS HUGO:FLT1 PMID: 28560064 Expression of Flt1 promotes glioblastoma cells migration, invasion</body> </html> </notes> <label text="FLT1"/> <bbox w="80.0" h="50.0" x="3602.5" y="322.5"/> <glyph class="unit of information" id="_a0875011-b423-430c-8a85-56bc26a7f962"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3620.0" y="317.5"/> </glyph> </glyph> <glyph class="macromolecule" id="gf1_s7_gf1_sa143" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:FLT4 MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:16530705 The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells</body> </html> </notes> <label text="FLT4"/> <bbox w="80.0" h="50.0" x="2982.5" y="322.5"/> <glyph class="unit of information" id="_d63a3aa2-2849-4bef-8759-d815fed4e5b8"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3000.0" y="317.5"/> </glyph> </glyph> <glyph class="macromolecule" id="gf1_s8_gf1_sa144" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>HUGO:MST1 MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:23792360 Both in vitro and in vivo evidence has revealed that MSP???RON signalling is important for the invasive growth of different types of cancers. Identifiers_begin: macrophage stimulating 1 (hepatocyte growth factor-like) D3F15S2 DNF15S2 HGFL HUGO:MST1 HGNC:7380 ENTREZ:4485 UNIPROT:P26927 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end</body> </html> </notes> <label text="MST1"/> <bbox w="80.0" h="40.0" x="2672.5" y="127.5"/> <glyph class="state variable" id="_4f7dfb7d-f969-4df8-976f-b27c05239a03"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2667.5" y="142.5"/> </glyph> </glyph> <glyph class="macromolecule" id="gf1_s9_gf1_sa145" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:MST1R MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:23792360 Both in vitro and in vivo evidence has revealed that MSP???RON signalling is important for the invasive growth of different types of cancers. RON activation results in the autophosphorylation of Tyr1238 and Tyr1239 at the A-loop (Phe1227???Pro1250) in the kinase domain93,95,98. Phosphorylation of these regulatory residues then activates the kinase activity, leading to further phosphorylation of Tyr1353 and Tyr1360 in the C-terminal docking site. The docking site interacts with downstream signalling proteins, triggering multiple intracellular pathways MSP???RON signalling activates two classical signalling pathways, RAS???ERK and PI3K???AKT, both of which interact with various other pathways to create a complex signalling network.</body> </html> </notes> <label text="MST1R"/> <bbox w="80.0" h="50.0" x="2802.5" y="322.5"/> <glyph class="state variable" id="_8d5a1203-c48d-45f6-98eb-d1abbd577a22"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2797.5" y="342.5"/> </glyph> <glyph class="unit of information" id="_ef52596d-d6bf-48f0-9f8c-b3f37d3e2a4e"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2820.0" y="317.5"/> </glyph> </glyph> <glyph class="phenotype" id="gf1_s5192_gf1_sa146" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID: 24703957 PDGFs pathways PMID:25772309 FGFs pathways PMID:28513565 EGFR pathways PMID:20388853 IGFR1 pathways PMID:23792360 MST1 pathways PMID:20303741 HGF</body> </html> </notes> <label text="MAPK_PATHWAYS"/> <bbox w="432.5" h="43.75" x="2506.25" y="1085.625"/> </glyph> <glyph class="phenotype" id="gf1_s5193_gf1_sa147" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID: 24703957 PDGFs pathways PMID:25772309 FGFs pathways PMID:28513565 EGFR pathways PMID:28475121 HGF/MET PMID:16951216 Vascular Endothelial Growth Factor Signaling Pathways</body> </html> </notes> <label text="PLCG_PATHWAYS"/> <bbox w="435.0" h="47.5" x="1195.0" y="1053.75"/> </glyph> <glyph class="phenotype" id="gf1_s5194_gf1_sa148" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID: 24703957 PDGFs pathways PMID:25772309 FGFs pathways PMID:28513565 EGFR pathways PMID: 20388853 IGF1R PMID:23792360 MST1 pathways PMID:28475121 HGF/MET PMID:16951216 Vascular Endothelial Growth Factor Signaling Pathways</body> </html> </notes> <label text="PI3K_PATHWAY"/> <bbox w="415.0" h="42.5" x="1815.0" y="1146.25"/> </glyph> <glyph class="phenotype" id="gf1_s5196_gf1_sa150" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID: 24703957 PDGFs pathways PMID:25772309 FGFs pathways PMID:24675568 EGFR/JAK/STAT STAT3 is a critical mediator of the oncogenic effects of EGFR mutations PMID:20303741 HGF</body> </html> </notes> <label text="JAK/STAT_PATHWAY"/> <bbox w="345.0" h="42.5" x="710.0" y="1146.25"/> </glyph> <glyph class="macromolecule" id="gf1_s5197_gf1_sa151" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:KL MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:25772309 The Fgf15/19 subfamily members encode endocrine FGFs, which bind to and activate FGFRs with the Klotho family protein as a cofactor.</body> </html> </notes> <label text="KL"/> <bbox w="80.0" h="40.0" x="902.5" y="547.5"/> </glyph> <glyph class="macromolecule" id="gf1_s5198_gf1_sa152" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:KLB MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:25772309 The Fgf15/19 subfamily members encode endocrine FGFs, which bind to and activate FGFRs with the Klotho family protein as a cofactor.</body> </html> </notes> <label text="KLB"/> <bbox w="80.0" h="40.0" x="902.5" y="467.5"/> </glyph> <glyph class="simple chemical" id="gf1_s5199_gf1_sa153" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:25772309 Canonical FGFs are tightly bound to heparin/heparan sulfate (HS) proteoglycans (HSPGs), which function to limit diffusion through the extracellular matrix (ECM) and serve as cofactors that regulate specificity and affinity for signaling FGFRs.</body> </html> </notes> <label text="HSPGs*"/> <bbox w="70.0" h="25.0" x="907.5" y="395.0"/> </glyph> <glyph class="complex" id="gf1_s5200_gf1_csa22" compartmentRef="gf1_c1_gf1_ca1"> <label text="gf1_s5200"/> <bbox w="100.0" h="120.0" x="622.5" y="507.5"/> <glyph class="macromolecule" id="gf1_s5201_gf1_sa41"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:FGFR1 HUGO:FGFR2 HUGO:FGFR3 HUGO:FGFR4 HUGO:FGFRL1 MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:25467007 FGFRs _rew PMID:25772309 Binding of canonical FGFs to FGFR with HS (or HSPG) as a cofactor induces the formation of ternary FGF???FGFR???HS complex, which activates the FGFR intracellular tyrosine kinase domain by phosphorylation of specific tyrosine residues. The activated receptor is coupled to intracellular signaling pathways including the RAS???MAPK, PI3K???AKT, PLC??, and STAT pathways.</body> </html> </notes> <label text="FGFR*"/> <bbox w="80.0" h="50.0" x="632.5" y="562.5"/> <glyph class="unit of information" id="_7d803cf0-0f78-4048-b5bf-920c3cd3713c"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="650.0" y="557.5"/> </glyph> </glyph> <glyph class="macromolecule" id="gf1_s5202_gf1_sa154"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:FGF1 HUGO:FGF2 HUGO:FGF3 HUGO:FGF4 HUGO:FGF5 HUGO:FGF6 HUGO:FGF7 HUGO:FGF8 HUGO:FGF9 HUGO:FGF10 HUGO:FGF11 HUGO:FGF12 HUGO:FGF13 HUGO:FGF14 HUGO:FGF16 HUGO:FGF17 HUGO:FGF18 HUGO:FGF19 HUGO:FGF20 HUGO:FGF21 HUGO:FGF22 HUGO:FGF23 MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:25772309 Deregulation of FGF signaling pathways have been implicated in many types of human and animal cancers.</body> </html> </notes> <label text="FGF*"/> <bbox w="80.0" h="40.0" x="632.5" y="517.5"/> </glyph> </glyph> <glyph class="complex" id="gf1_s5203_gf1_csa23" compartmentRef="gf1_c1_gf1_ca1"> <label text="gf1_s5203"/> <bbox w="100.0" h="120.0" x="2662.5" y="517.5"/> <glyph class="macromolecule" id="gf1_s5204_gf1_sa156"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>HUGO:MST1 MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:23792360 Both in vitro and in vivo evidence has revealed that MSP???RON signalling is important for the invasive growth of different types of cancers. Identifiers_begin: macrophage stimulating 1 (hepatocyte growth factor-like) D3F15S2 DNF15S2 HGFL HUGO:MST1 HGNC:7380 ENTREZ:4485 UNIPROT:P26927 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end</body> </html> </notes> <label text="MST1"/> <bbox w="80.0" h="40.0" x="2672.5" y="527.5"/> <glyph class="state variable" id="_d931b33d-72e8-42dd-a4dd-4130e2586bf9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2667.5" y="542.5"/> </glyph> </glyph> <glyph class="macromolecule" id="gf1_s5205_gf1_sa157"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:MST1R MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:23792360 Both in vitro and in vivo evidence has revealed that MSP???RON signalling is important for the invasive growth of different types of cancers. RON activation results in the autophosphorylation of Tyr1238 and Tyr1239 at the A-loop (Phe1227???Pro1250) in the kinase domain93,95,98. Phosphorylation of these regulatory residues then activates the kinase activity, leading to further phosphorylation of Tyr1353 and Tyr1360 in the C-terminal docking site. The docking site interacts with downstream signalling proteins, triggering multiple intracellular pathways MSP???RON signalling activates two classical signalling pathways, RAS???ERK and PI3K???AKT, both of which interact with various other pathways to create a complex signalling network.</body> </html> </notes> <label text="MST1R"/> <bbox w="80.0" h="50.0" x="2672.5" y="572.5"/> <glyph class="state variable" id="_8986f738-f7e2-4be2-bfb5-cfb4fc4bcc42"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2665.0" y="592.5"/> </glyph> <glyph class="unit of information" id="_29f59994-b95e-481b-9ef4-18f80d0333f8"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2690.0" y="567.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="gf1_s5206_gf1_csa24" compartmentRef="gf1_c1_gf1_ca1"> <label text="gf1_s5206"/> <bbox w="100.0" h="120.0" x="3032.5" y="517.5"/> <glyph class="macromolecule" id="gf1_s5207_gf1_sa158"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:FLT4 MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:16530705 The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells</body> </html> </notes> <label text="FLT4"/> <bbox w="80.0" h="50.0" x="3042.5" y="562.5"/> <glyph class="unit of information" id="_08655090-509c-4c49-a4f1-a36a8c17c0d6"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3060.0" y="557.5"/> </glyph> </glyph> <glyph class="macromolecule" id="gf1_s5208_gf1_sa159"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:VEGFA HUGO:VEGFB HUGO:VEGFC HUGO:VEGFD HUGO:PGF MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:16951216 Vascular Endothelial Growth Factor Signaling Pathways</body> </html> </notes> <label text="VEGF*"/> <bbox w="80.0" h="40.0" x="3042.5" y="527.5"/> </glyph> </glyph> <glyph class="macromolecule" id="gf1_s3866_gf1_sa137" compartmentRef="gf1_c1_gf1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:KDR MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:17883421 Activated Vegfr2/kdr Pathway In Tumour Cells And Tumour Associated Vessels Of Colorectal Cancer</body> </html> </notes> <label text="KDR"/> <bbox w="80.0" h="50.0" x="3252.5" y="322.5"/> <glyph class="unit of information" id="_02ed7b2e-e650-4793-b8a1-641d5b292e86"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3270.0" y="317.5"/> </glyph> </glyph> <glyph class="complex" id="gf1_s5209_gf1_csa20" compartmentRef="gf1_c1_gf1_ca1"> <label text="KDR:VEGF*"/> <bbox w="100.0" h="120.0" x="3292.5" y="517.5"/> <glyph class="macromolecule" id="gf1_s3910_gf1_sa139"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:KDR MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:17883421 Activated Vegfr2/kdr Pathway In Tumour Cells And Tumour Associated Vessels Of Colorectal Cancer</body> </html> </notes> <label text="KDR"/> <bbox w="80.0" h="50.0" x="3302.5" y="572.5"/> <glyph class="unit of information" id="_9dafa460-33d8-45cf-b0af-045bd3c89b6e"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3320.0" y="567.5"/> </glyph> </glyph> <glyph class="macromolecule" id="gf1_s3911_gf1_sa140"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:VEGFA HUGO:VEGFB HUGO:VEGFC HUGO:VEGFD HUGO:PGF MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:16951216 Vascular Endothelial Growth Factor Signaling Pathways</body> </html> </notes> <label text="VEGF*"/> <bbox w="80.0" h="40.0" x="3302.5" y="527.5"/> </glyph> </glyph> <glyph class="complex" id="gf1_s5210_gf1_csa21" compartmentRef="gf1_c1_gf1_ca1"> <label text="FLT1:VEGF*"/> <bbox w="100.0" h="130.0" x="3542.5" y="512.5"/> <glyph class="macromolecule" id="gf1_s4495_gf1_sa142"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>HUGO:VEGFA HUGO:VEGFB HUGO:VEGFC HUGO:VEGFD HUGO:PGF MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:16951216 Vascular Endothelial Growth Factor Signaling Pathways</body> </html> </notes> <label text="VEGF*"/> <bbox w="80.0" h="40.0" x="3552.5" y="517.5"/> </glyph> <glyph class="macromolecule" id="gf1_s3915_gf1_sa141"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS HUGO:FLT1 PMID: 28560064 Expression of Flt1 promotes glioblastoma cells migration, invasion</body> </html> </notes> <label text="FLT1"/> <bbox w="80.0" h="50.0" x="3552.5" y="572.5"/> <glyph class="unit of information" id="_7f54f128-764c-40c3-b64a-d49391973b84"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3570.0" y="567.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s23_mpk1_mpk1_csa75" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TNFRSF1B:TRAF2 Identifiers_end</body> </html> </notes> <label text="TNFRSF1B:TRAF2"/> <bbox w="132.0" h="80.0" x="2725.9963" y="1509.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s727_mpk1_mpk1_sa439"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TNF receptor-associated factor 2 HUGO:TRAF2 HGNC:12032 ENTREZ:7186 UNIPROT:Q12933 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TRAF proteins are recruited to the TRADD-TNFR1 complex. TRADD couples TNFR1 to TRAF2. TRAF2 directly interacts with TNFR2. ERN1 activation is likely to trigger binding and activation of TRAF2. PMID:11274345 References_end</body> </html> </notes> <label text="TRAF2"/> <bbox w="50.0" h="25.0" x="2765.4963" y="1540.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s24_mpk1_mpk1_sa440"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tumor necrosis factor receptor superfamily member 1B TNFR2 HUGO:TNFRSF1B HGNC:11917 ENTREZ:7133 UNIPROT:P20333 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins (TRAF2). PMID:11274345 References_end</body> </html> </notes> <label text="TNFRSF1B"/> <bbox w="70.0" h="25.0" x="2757.4963" y="1516.0"/> <glyph class="unit of information" id="_0022ef53-ef9f-4182-8d9e-bbb6c705158a"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2769.9963" y="1511.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s14_mpk1_mpk1_csa74" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:RIPK1:TNFRSF1A:TRADD:TRAF2 Identifiers_end</body> </html> </notes> <label text="RIPK1:TNFRSF1A:TRADD:TRAF2"/> <bbox w="216.0" h="85.0" x="2445.9963" y="1647.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s18_mpk1_mpk1_sa436"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TNFRSF1A-associated via death domain HUGO:TRADD HGNC:12030 ENTREZ:8717 UNIPROT:Q15628 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins. PMID:11274345 References_end</body> </html> </notes> <label text="TRADD"/> <bbox w="50.0" h="25.0" x="2567.4963" y="1655.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s19_mpk1_mpk1_sa437"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TNF receptor-associated factor 2 HUGO:TRAF2 HGNC:12032 ENTREZ:7186 UNIPROT:Q12933 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TRAF proteins are recruited to the TRADD-TNFR1 complex. TRADD couples TNFR1 to TRAF2. TRAF2 directly interacts with TNFR2. ERN1 activation is likely to trigger binding and activation of TRAF2. PMID:11274345 References_end</body> </html> </notes> <label text="TRAF2"/> <bbox w="50.0" h="25.0" x="2504.4963" y="1680.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s20_mpk1_mpk1_sa438"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: receptor (TNFRSF)-interacting serine-threonine kinase 1 HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TNF treatment is thought to result in the formation of a TRADD-RIP-TRAF2 complex at the membrane. PMID:11274345 References_end</body> </html> </notes> <label text="RIPK1"/> <bbox w="50.0" h="25.0" x="2554.4963" y="1680.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s831_mpk1_mpk1_sa593"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tumor necrosis factor receptor superfamily member 1A TNFR1 HUGO:TNFRSF1A HGNC:11916 ENTREZ:7132 UNIPROT:P19438 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins. PMID:11274345 References_end</body> </html> </notes> <label text="TNFRSF1A"/> <bbox w="70.0" h="25.0" x="2496.4546" y="1656.0"/> <glyph class="unit of information" id="_db03f7ae-22e3-47b2-86d5-d363581a63a0"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2508.9546" y="1651.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s15_mpk1_mpk1_csa72" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TNFRSF1A:TRADD:TRAF2 Identifiers_end</body> </html> </notes> <label text="TNFRSF1A:TRADD:TRAF2"/> <bbox w="180.0" h="113.0" x="2451.9963" y="1501.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s1_mpk1_mpk1_sa430"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TNFRSF1A-associated via death domain HUGO:TRADD HGNC:12030 ENTREZ:8717 UNIPROT:Q15628 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins. PMID:11274345 References_end</body> </html> </notes> <label text="TRADD"/> <bbox w="55.0" h="25.0" x="2512.9963" y="1535.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s2_mpk1_mpk1_sa431"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tumor necrosis factor receptor superfamily member 1A TNFR1 HUGO:TNFRSF1A HGNC:11916 ENTREZ:7132 UNIPROT:P19438 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins. PMID:11274345 References_end</body> </html> </notes> <label text="TNFRSF1A"/> <bbox w="70.0" h="25.0" x="2507.9963" y="1511.0"/> <glyph class="unit of information" id="_9abb73ee-fb8b-4721-82ae-b26d697f571e"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2520.4963" y="1506.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s3_mpk1_mpk1_sa432"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TNF receptor-associated factor 2 HUGO:TRAF2 HGNC:12032 ENTREZ:7186 UNIPROT:Q12933 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TRAF proteins are recruited to the TRADD-TNFR1 complex. TRADD couples TNFR1 to TRAF2. TRAF2 directly interacts with TNFR2. ERN1 activation is likely to trigger binding and activation of TRAF2. PMID:11274345 References_end</body> </html> </notes> <label text="TRAF2"/> <bbox w="50.0" h="25.0" x="2514.9963" y="1561.0"/> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s16_mpk1_mpk1_csa73" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TNFRSF1A:TRADD Identifiers_end</body> </html> </notes> <label text="TNFRSF1A:TRADD"/> <bbox w="126.0" h="83.0" x="2421.9963" y="1392.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s7_mpk1_mpk1_sa434"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TNFRSF1A-associated via death domain HUGO:TRADD HGNC:12030 ENTREZ:8717 UNIPROT:Q15628 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins. PMID:11274345 References_end</body> </html> </notes> <label text="TRADD"/> <bbox w="50.0" h="25.0" x="2459.4963" y="1424.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s830_mpk1_mpk1_sa592"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tumor necrosis factor receptor superfamily member 1A TNFR1 HUGO:TNFRSF1A HGNC:11916 ENTREZ:7132 UNIPROT:P19438 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins. PMID:11274345 References_end</body> </html> </notes> <label text="TNFRSF1A"/> <bbox w="70.0" h="25.0" x="2450.0" y="1401.0"/> <glyph class="unit of information" id="_5997f1e3-b729-494f-aabd-4804947302e7"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2462.5" y="1396.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s49_mpk1_mpk1_csa80" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TGFBR1:TGFBR2 Identifiers_end</body> </html> </notes> <label text="TGFBR1:TGFBR2"/> <bbox w="130.0" h="64.0" x="3419.9963" y="1314.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s46_mpk1_mpk1_sa453"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transforming growth factor beta receptor 1 "transforming growth factor beta receptor I (activin A receptor type II-like kinase 53kD)" HUGO:TGFBR1 HGNC:11772 ENTREZ:7046 UNIPROT:P36897 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TGF-beta is known to cause a hetero-oligomerisation of the TGFBR1/TGFBR2 complex consisting of two TGFBR1 and two TGFBR2 molecules to activate it (not modelled). Besides cellular stresses the SAPK pathways are also activated by cytokines such as TGF-beta. Smad-dependent gene expression can provoke P38 activation in response to TGFbeta. PMID:20060931 PMID:21614932 References_end</body> </html> </notes> <label text="TGFBR1"/> <bbox w="55.0" h="25.0" x="3430.9963" y="1325.0"/> <glyph class="unit of information" id="_4ea1af92-9f2a-40d7-9123-21f4c106d0de"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3435.9963" y="1320.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s47_mpk1_mpk1_sa454"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transforming growth factor beta receptor II (70/80kDa) MFS2 "transforming growth factor beta receptor II (70-80kD)" HUGO:TGFBR2 HGNC:11773 ENTREZ:7048 UNIPROT:P37173 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TGF-beta is known to cause a hetero-oligomerisation of the TGFBR1/TGFBR2 complex consisting of two TGFBR1 and two TGFBR2 molecules to activate it (not modelled). Besides cellular stresses the SAPK pathways are also activated by cytokines such as TGF-beta. Smad-dependent gene expression can provoke P38 activation in response to TGFbeta. PMID:20060931 PMID:21614932 References_end</body> </html> </notes> <label text="TGFBR2"/> <bbox w="55.0" h="25.0" x="3485.9963" y="1326.0"/> <glyph class="unit of information" id="_ab15a528-3969-486a-98ab-a3980c795b93"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3490.9963" y="1321.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1000_mpk1_mpk1_csa76" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TAB*:TGFBR1:TGFBR2 Identifiers_end</body> </html> </notes> <label text="TAB*:TGFBR1:TGFBR2"/> <bbox w="143.0" h="81.0" x="3285.9963" y="1619.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s728_mpk1_mpk1_sa443"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 1 MAP3K7IP1 "mitogen-activated protein kinase kinase kinase 7 interacting protein 1" HUGO:TAB1 HGNC:18157 ENTREZ:10454 UNIPROT:Q15750 TGF-beta activated kinase 1/MAP3K7 binding protein 2 MAP3K7IP2 "mitogen-activated protein kinase kinase kinase 7 interacting protein 2" HUGO:TAB2 HGNC:17075 ENTREZ:23118 UNIPROT:Q9NYJ8 TGF-beta activated kinase 1/MAP3K7 binding protein 3 MAP3K7IP3 "mitogen-activated protein kinase kinase kinase 7 interacting protein 3" HUGO:TAB3 HGNC:30681 ENTREZ:257397 UNIPROT:Q8N5C8 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TAK1 is the only MAP3K that requires the adapter proteins TAB123 for its activation. PMID:20060931 References_end</body> </html> </notes> <label text="TAB*"/> <bbox w="50.0" h="25.0" x="3301.163" y="1650.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s835_mpk1_mpk1_sa597"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transforming growth factor beta receptor 1 "transforming growth factor beta receptor I (activin A receptor type II-like kinase 53kD)" HUGO:TGFBR1 HGNC:11772 ENTREZ:7046 UNIPROT:P36897 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TGF-beta is known to cause a hetero-oligomerisation of the TGFBR1/TGFBR2 complex consisting of two TGFBR1 and two TGFBR2 molecules to activate it (not modelled). Besides cellular stresses the SAPK pathways are also activated by cytokines such as TGF-beta. Smad-dependent gene expression can provoke P38 activation in response to TGFbeta. PMID:20060931 PMID:21614932 References_end</body> </html> </notes> <label text="TGFBR1"/> <bbox w="55.0" h="25.0" x="3301.2727" y="1629.0"/> <glyph class="unit of information" id="_62ea3e7e-dca8-4ab8-983f-a00ce0d3f00b"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3306.2727" y="1624.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s55_mpk1_mpk1_sa598"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transforming growth factor beta receptor II (70/80kDa) MFS2 "transforming growth factor beta receptor II (70-80kD)" HUGO:TGFBR2 HGNC:11773 ENTREZ:7048 UNIPROT:P37173 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TGF-beta is known to cause a hetero-oligomerisation of the TGFBR1/TGFBR2 complex consisting of two TGFBR1 and two TGFBR2 molecules to activate it (not modelled). Besides cellular stresses the SAPK pathways are also activated by cytokines such as TGF-beta. Smad-dependent gene expression can provoke P38 activation in response to TGFbeta. PMID:20060931 PMID:21614932 References_end</body> </html> </notes> <label text="TGFBR2"/> <bbox w="55.0" h="25.0" x="3357.2727" y="1630.0"/> <glyph class="unit of information" id="_e823a417-2438-4391-812c-17ec77473be3"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3362.2727" y="1625.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s981_mpk1_mpk1_csa31" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:RTK*:SRC Identifiers_end</body> </html> </notes> <label text="RTK*:SRC"/> <bbox w="72.0" h="88.0" x="198.0" y="1403.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s273_mpk1_mpk1_sa164"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) SRC1 "v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog" HUGO:SRC HGNC:11283 ENTREZ:6714 UNIPROT:P12931 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Many activated RTKs induce the Src-dependent activation of PLCG PMID:17496910 References_end Identifiers_begin: v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) SRC1 "v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog" HUGO:SRC HGNC:11283 ENTREZ:6714 UNIPROT:P12931 GENECARDS:SRC REACTOME:402877 KEGG:6714 ATLASONC:SRCID448ch20q11 WIKI:SRC Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Many activated RTKs induce the Src-dependent activation of PLCG PMID:17496910 References_end</body> </html> </notes> <label text="SRC"/> <bbox w="50.0" h="25.0" x="207.0" y="1438.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s820_mpk1_mpk1_sa582"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> </notes> <label text="RTK*"/> <bbox w="50.0" h="25.0" x="208.27272" y="1417.0"/> <glyph class="state variable" id="_f5321eac-0dbb-43ce-96be-c326882f6f21"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="253.27272" y="1429.6776"/> </glyph> <glyph class="state variable" id="_d5e2973a-53ba-4be1-aca2-453878bfa86c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="253.27272" y="1429.6776"/> </glyph> <glyph class="state variable" id="_9803efb0-8fbd-4569-8afc-a897e5ee6141"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="253.27272" y="1424.5"/> </glyph> <glyph class="unit of information" id="_353967c9-5587-49c8-b8bd-b7ddf09cfb3e"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="210.77272" y="1412.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s987_mpk1_mpk1_csa32" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PLCG1:RTK*:SRC Identifiers_end</body> </html> </notes> <label text="PLCG1:RTK*:SRC"/> <bbox w="113.0" h="115.0" x="215.0" y="1521.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s284_mpk1_mpk1_sa173"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) SRC1 "v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog" HUGO:SRC HGNC:11283 ENTREZ:6714 UNIPROT:P12931 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Many activated RTKs induce the Src-dependent activation of PLCG PMID:17496910 References_end Identifiers_begin: v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) SRC1 "v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog" HUGO:SRC HGNC:11283 ENTREZ:6714 UNIPROT:P12931 GENECARDS:SRC REACTOME:402877 KEGG:6714 ATLASONC:SRCID448ch20q11 WIKI:SRC Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Many activated RTKs induce the Src-dependent activation of PLCG PMID:17496910 References_end</body> </html> </notes> <label text="SRC"/> <bbox w="50.0" h="25.0" x="245.0" y="1557.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s285_mpk1_mpk1_sa174"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: phospholipase C gamma 1 "phospholipase C gamma 1 (formerly subtype 148)" PLC1 HUGO:PLCG1 HGNC:9065 ENTREZ:5335 UNIPROT:P19174 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: In response to Src-dependent activation of PLCG1 RasGRP1 translocated to the Golgi where it activated Ras. PMID:12845332 References_end</body> </html> </notes> <label text="PLCG1"/> <bbox w="50.0" h="25.0" x="245.0" y="1582.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s821_mpk1_mpk1_sa583"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> </notes> <label text="RTK*"/> <bbox w="50.0" h="25.0" x="245.27272" y="1534.0"/> <glyph class="state variable" id="_23401b8b-0535-4420-b5ed-7545fc8f7012"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="290.2727" y="1546.6776"/> </glyph> <glyph class="state variable" id="_0024d82d-b012-469b-9d9c-0ef95b330bb3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="290.2727" y="1546.6776"/> </glyph> <glyph class="state variable" id="_9fa774c5-c1ee-40d8-937a-69086107bf23"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="290.2727" y="1541.5"/> </glyph> <glyph class="unit of information" id="_7b146f29-e885-4544-acd9-ded81736812c"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="247.77272" y="1529.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s32_mpk1_mpk1_csa77" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:IL1R1:MYD88 Identifiers_end</body> </html> </notes> <label text="IL1R1:MYD88"/> <bbox w="97.0" h="81.0" x="3071.9963" y="1437.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s33_mpk1_mpk1_sa445"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: myeloid differentiation primary response 88 "myeloid differentiation primary response gene (88)" HUGO:MYD88 HGNC:7562 ENTREZ:4615 UNIPROT:Q99836 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: The IL-1R/IL-1RAcP heterodimer recruits the death domain adapter protein MyD88. PMID:11274345 References_end</body> </html> </notes> <label text="MYD88"/> <bbox w="59.0" h="24.0" x="3090.4963" y="1468.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s833_mpk1_mpk1_sa596"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: interleukin 1 receptor type I IL1R IL1RA HUGO:IL1R1 HGNC:5993 ENTREZ:3554 UNIPROT:P14778 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: IL-1 likely requires TRAF6 to signal to the SAPKs. IL-1 binding to its receptor (IL-1R) triggers heterodimerisation of IL-1R with IL-1RAcP (not modelled) a transmembrane protein necessary for IL-1 signal transduction. The IL-1R/IL-1RAcP heterodimer then recruits the death domain adapter protein MyD88. PMID:11274345 References_end</body> </html> </notes> <label text="IL1R1"/> <bbox w="50.0" h="25.0" x="3095.4546" y="1446.0"/> <glyph class="unit of information" id="_e1c9e259-6b8c-4aa2-9ea1-1cc160d1727a"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3097.9546" y="1441.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s705_mpk1_mpk1_csa78" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:IL1R1:IRAK1:MYD88:TRAF6 Identifiers_end</body> </html> </notes> <label text="IL1R1:IRAK1:MYD88:TRAF6"/> <bbox w="190.0" h="85.0" x="3035.9963" y="1658.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s42_mpk1_mpk1_sa447"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: myeloid differentiation primary response 88 "myeloid differentiation primary response gene (88)" HUGO:MYD88 HGNC:7562 ENTREZ:4615 UNIPROT:Q99836 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: The IL-1R/IL-1RAcP heterodimer recruits the death domain adapter protein MyD88. PMID:11274345 References_end</body> </html> </notes> <label text="MYD88"/> <bbox w="56.0" h="25.0" x="3076.4963" y="1692.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s40_mpk1_mpk1_sa448"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: interleukin-1 receptor-associated kinase 1 HUGO:IRAK1 HGNC:6112 ENTREZ:3654 UNIPROT:P51617 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Similar to RIP recruitment by TRADD the death domain of receptor-bound MyD88 binds IRAK1. PMID:11274345 References_end</body> </html> </notes> <label text="IRAK1"/> <bbox w="50.0" h="25.0" x="3132.4963" y="1692.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s41_mpk1_mpk1_sa449"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TNF receptor-associated factor 6 E3 ubiquitin protein ligase "TNF receptor-associated factor 6" HUGO:TRAF6 HGNC:12036 ENTREZ:7189 UNIPROT:Q9Y4K3 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Upon recruitment to the IL-1R complex IRAK1 binds TRAF6 forming a MyD88-IRAK1-TRAF6 complex analogous to the TNFR-associated complex of TRADD RIP and TRAF2. PMID:11274345 References_end</body> </html> </notes> <label text="TRAF6"/> <bbox w="50.0" h="25.0" x="3128.4963" y="1666.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s832_mpk1_mpk1_sa594"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: interleukin 1 receptor type I IL1R IL1RA HUGO:IL1R1 HGNC:5993 ENTREZ:3554 UNIPROT:P14778 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: IL-1 likely requires TRAF6 to signal to the SAPKs. IL-1 binding to its receptor (IL-1R) triggers heterodimerisation of IL-1R with IL-1RAcP (not modelled) a transmembrane protein necessary for IL-1 signal transduction. The IL-1R/IL-1RAcP heterodimer then recruits the death domain adapter protein MyD88. PMID:11274345 References_end</body> </html> </notes> <label text="IL1R1"/> <bbox w="50.0" h="25.0" x="3078.4546" y="1668.0"/> <glyph class="unit of information" id="_3f6afa60-2bb0-4e7b-9490-37c76f9a2425"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3080.9546" y="1663.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s999_mpk1_mpk1_csa79" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:IL1R1:IRAK1:MYD88 Identifiers_end</body> </html> </notes> <label text="IL1R1:IRAK1:MYD88"/> <bbox w="145.0" h="84.0" x="3068.9963" y="1552.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s36_mpk1_mpk1_sa451"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: myeloid differentiation primary response 88 "myeloid differentiation primary response gene (88)" HUGO:MYD88 HGNC:7562 ENTREZ:4615 UNIPROT:Q99836 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: The IL-1R/IL-1RAcP heterodimer recruits the death domain adapter protein MyD88. PMID:11274345 References_end</body> </html> </notes> <label text="MYD88"/> <bbox w="59.0" h="25.0" x="3086.4963" y="1583.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s37_mpk1_mpk1_sa452"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: interleukin-1 receptor-associated kinase 1 HUGO:IRAK1 HGNC:6112 ENTREZ:3654 UNIPROT:P51617 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Similar to RIP recruitment by TRADD the death domain of receptor-bound MyD88 binds IRAK1. PMID:11274345 References_end</body> </html> </notes> <label text="IRAK1"/> <bbox w="50.0" h="25.0" x="3145.4963" y="1583.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s834_mpk1_mpk1_sa595"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: interleukin 1 receptor type I IL1R IL1RA HUGO:IL1R1 HGNC:5993 ENTREZ:3554 UNIPROT:P14778 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: IL-1 likely requires TRAF6 to signal to the SAPKs. IL-1 binding to its receptor (IL-1R) triggers heterodimerisation of IL-1R with IL-1RAcP (not modelled) a transmembrane protein necessary for IL-1 signal transduction. The IL-1R/IL-1RAcP heterodimer then recruits the death domain adapter protein MyD88. PMID:11274345 References_end</body> </html> </notes> <label text="IL1R1"/> <bbox w="50.0" h="25.0" x="3090.4546" y="1561.0"/> <glyph class="unit of information" id="_a33d6764-662f-4785-b24d-12ca6771fb4f"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3092.9546" y="1556.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s989_mpk1_mpk1_csa6" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GRB2:RTK*:SOS* Identifiers_end</body> </html> </notes> <label text="GRB2:RTK*:SOS*"/> <bbox w="109.0" h="104.0" x="791.0" y="1387.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s764_mpk1_mpk1_sa26"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 References_end Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 GENECARDS:SOS1 REACTOME:64848 KEGG:6654 ATLASONC:GC_SOS1 WIKI:SOS1 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 GENECARDS:SOS2 REACTOME:64850 ATLASONC:GC_SOS2 WIKI:SOS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="SOS*"/> <bbox w="50.0" h="25.0" x="819.5" y="1440.5"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s887_mpk1_mpk1_sa27"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 References_end Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 GENECARDS:GRB2 REACTOME:404631 KEGG:2885 ATLASONC:GRB2ID386ch17q25 WIKI:GRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="GRB2"/> <bbox w="50.0" h="25.0" x="820.5" y="1415.5"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s888_mpk1_mpk1_sa32"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> </notes> <label text="RTK*"/> <bbox w="50.0" h="25.0" x="821.5" y="1392.5"/> <glyph class="state variable" id="_e60cbcec-0054-4bf0-8c06-8eedd8548ee8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="866.5" y="1405.1776"/> </glyph> <glyph class="state variable" id="_23ce26b9-1088-4a58-ba3d-32471a8d3cd1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="866.5" y="1405.1776"/> </glyph> <glyph class="state variable" id="_50caaf78-b699-4073-8a50-08a1513e8802"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="866.5" y="1400.0"/> </glyph> <glyph class="unit of information" id="_2ec9604d-cdc1-462d-b384-e101fa03d87c"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="824.0" y="1387.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s991_mpk1_mpk1_csa3" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GRB2:RAS*:RTK*:SOS* Identifiers_end</body> </html> </notes> <label text="GRB2:RAS*:RTK*:SOS*"/> <bbox w="143.0" h="103.0" x="876.0" y="1657.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s758_mpk1_mpk1_sa11"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> </notes> <label text="RAS*"/> <bbox w="50.0" h="25.0" x="901.0" y="1713.0"/> <glyph class="state variable" id="_03a32025-6e7e-4b83-82c6-246395c79c74"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="893.5" y="1720.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s759_mpk1_mpk1_sa15"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 References_end Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 GENECARDS:SOS1 REACTOME:64848 KEGG:6654 ATLASONC:GC_SOS1 WIKI:SOS1 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 GENECARDS:SOS2 REACTOME:64850 ATLASONC:GC_SOS2 WIKI:SOS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="SOS*"/> <bbox w="50.0" h="25.0" x="949.5" y="1715.5"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s760_mpk1_mpk1_sa30"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 References_end Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 GENECARDS:GRB2 REACTOME:404631 KEGG:2885 ATLASONC:GRB2ID386ch17q25 WIKI:GRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="GRB2"/> <bbox w="50.0" h="25.0" x="950.5" y="1688.5"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s761_mpk1_mpk1_sa34"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> </notes> <label text="RTK*"/> <bbox w="50.0" h="25.0" x="950.5" y="1665.5"/> <glyph class="state variable" id="_823cc8ac-9f45-436a-86f6-e1d0ab751574"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="995.5" y="1678.1776"/> </glyph> <glyph class="state variable" id="_26dfca1c-d21a-4832-a857-7687d486c2f6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="995.5" y="1678.1776"/> </glyph> <glyph class="state variable" id="_1f0ff98d-0c84-44e5-90ea-cb0ad634b239"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="995.5" y="1673.0"/> </glyph> <glyph class="unit of information" id="_82d1cceb-4290-47e5-869a-be3cc760b09b"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="953.0" y="1660.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s992_mpk1_mpk1_csa68" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GRB2:RAF1:RAS*:RTK*:SOS* Identifiers_end</body> </html> </notes> <label text="GRB2:RAF1:RAS*:RTK*:SOS*"/> <bbox w="185.0" h="106.0" x="1150.0" y="1641.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s752_mpk1_mpk1_sa333"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 References_end Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 GENECARDS:GRB2 REACTOME:404631 KEGG:2885 ATLASONC:GRB2ID386ch17q25 WIKI:GRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="GRB2"/> <bbox w="50.0" h="25.0" x="1271.0" y="1674.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s753_mpk1_mpk1_sa334"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 References_end Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 GENECARDS:SOS1 REACTOME:64848 KEGG:6654 ATLASONC:GC_SOS1 WIKI:SOS1 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 GENECARDS:SOS2 REACTOME:64850 ATLASONC:GC_SOS2 WIKI:SOS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="SOS*"/> <bbox w="50.0" h="25.0" x="1270.0" y="1699.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s572_mpk1_mpk1_sa337"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: v-raf-1 murine leukemia viral oncogene homolog 1 HUGO:RAF1 HGNC:9829 ENTREZ:5894 UNIPROT:P04049 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Active KRas (on late endosomes) recruits Raf1 (C-Raf) to elicit a MODULE:MAPK signalling pathway. Raf1 MEK1/2 and ERK1/2 may act in the outer side of the Golgi apparatus and attenuate proliferation. PMID:19289794 PMID:19565474 References_end Identifiers_begin: v-raf-1 murine leukemia viral oncogene homolog 1 HUGO:RAF1 HGNC:9829 ENTREZ:5894 UNIPROT:P04049 GENECARDS:RAF1 REACTOME:58255 KEGG:5894 ATLASONC:RAF1ID42032ch3p25 WIKI:RAF1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Active KRas (on late endosomes) recruits Raf1 (C-Raf) to elicit a MODULE:MAPK signalling pathway. Raf1 MEK1/2 and ERK1/2 may act in the outer side of the Golgi apparatus and attenuate proliferation. PMID:19289794 PMID:19565474 References_end</body> </html> </notes> <label text="RAF1"/> <bbox w="66.0" h="26.0" x="1166.0" y="1699.0"/> <glyph class="state variable" id="_a8cc4159-df92-443d-8152-f2b6a34326f9"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1158.5" y="1707.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s824_mpk1_mpk1_sa585"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> </notes> <label text="RTK*"/> <bbox w="50.0" h="25.0" x="1271.0" y="1651.0"/> <glyph class="state variable" id="_742a9d15-fd7e-4df3-a356-ad5c7f6a2e7a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1316.0" y="1663.6776"/> </glyph> <glyph class="state variable" id="_0eb6014a-bc72-4a54-a570-0f600a8047be"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1316.0" y="1663.6776"/> </glyph> <glyph class="state variable" id="_c84b5a3d-ee91-4d8a-ac5c-5a068f1a80e7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1316.0" y="1658.5"/> </glyph> <glyph class="unit of information" id="_6a7045dc-fccf-4920-9639-a66d6ef8010a"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="1273.5" y="1646.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s858_mpk1_mpk1_sa619"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> </notes> <label text="RAS*"/> <bbox w="50.0" h="25.0" x="1227.375" y="1698.5"/> <glyph class="state variable" id="_393a9e32-5d8c-4b46-8579-58fef0a14eff"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1219.875" y="1706.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s990_mpk1_mpk1_csa99" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GRB2:RAC1:RTK*:SOS* Identifiers_end</body> </html> </notes> <label text="GRB2:RAC1:RTK*:SOS*"/> <bbox w="152.0" h="103.0" x="1168.9965" y="1393.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s621_mpk1_mpk1_sa522"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 References_end Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 GENECARDS:GRB2 REACTOME:404631 KEGG:2885 ATLASONC:GRB2ID386ch17q25 WIKI:GRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="GRB2"/> <bbox w="50.0" h="25.0" x="1248.4965" y="1421.5"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s622_mpk1_mpk1_sa523"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 References_end Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 GENECARDS:SOS1 REACTOME:64848 KEGG:6654 ATLASONC:GC_SOS1 WIKI:SOS1 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 GENECARDS:SOS2 REACTOME:64850 ATLASONC:GC_SOS2 WIKI:SOS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="SOS*"/> <bbox w="50.0" h="25.0" x="1248.4965" y="1445.5"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s624_mpk1_mpk1_sa524"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <bbox w="60.0" h="25.0" x="1194.4965" y="1445.0"/> <glyph class="state variable" id="_6a9a87e5-92ba-4ee1-86d8-7d08d59982b3"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1186.9965" y="1452.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s822_mpk1_mpk1_sa587"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> </notes> <label text="RTK*"/> <bbox w="50.0" h="25.0" x="1249.0" y="1401.0"/> <glyph class="state variable" id="_dba5ccf0-7364-4409-bc32-0dee5597ea9b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1294.0" y="1413.6776"/> </glyph> <glyph class="state variable" id="_e0dc7f31-61aa-44a0-8b9e-6ec331f14397"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1294.0" y="1413.6776"/> </glyph> <glyph class="state variable" id="_5993c183-2121-4e9f-a911-05fef9fb9533"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1294.0" y="1408.5"/> </glyph> <glyph class="unit of information" id="_00adca0a-82a5-4897-8168-dbaa2b3c4ebf"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="1251.5" y="1396.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s997_mpk1_mpk1_csa64" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GPCR*:GRK* Identifiers_end</body> </html> </notes> <label text="GPCR*:GRK*"/> <bbox w="81.0" h="81.0" x="2197.0" y="1414.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s543_mpk1_mpk1_sa316"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adrenergic beta receptor kinase 1 HUGO:ADRBK1 HGNC:289 ENTREZ:156 UNIPROT:P25098 adrenergic beta receptor kinase 2 HUGO:ADRBK2 HGNC:290 ENTREZ:157 UNIPROT:P35626 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN. PMID:11226259 References_end Identifiers_begin: G protein-coupled receptor kinase 1 HUGO:GRK1 HGNC:10013 ENTREZ:6011 UNIPROT:Q15835 GENECARDS:GRK1 KEGG:6011 ATLASONC:GC_GRK1 WIKI:GRK1 G protein-coupled receptor kinase 4 HUGO:GRK4 HGNC:4543 ENTREZ:2868 UNIPROT:P32298 GENECARDS:GRK4 KEGG:2868 ATLASONC:GC_GRK4 WIKI:GRK4 G protein-coupled receptor kinase 5 HUGO:GRK5 HGNC:4544 ENTREZ:2869 UNIPROT:P34947 GENECARDS:GRK5 REACTOME:55956 KEGG:2869 WIKI:GRK5 G protein-coupled receptor kinase 6 HUGO:GRK6 HGNC:4545 ENTREZ:2870 UNIPROT:P43250 GENECARDS:GRK6 KEGG:2870 ATLASONC:GC_GRK6 WIKI:GRK6 G protein-coupled receptor kinase 7 HUGO:GRK7 HGNC:17031 ENTREZ:131890 UNIPROT:Q8WTQ7 GENECARDS:GRK7 KEGG:131890 WIKI:GRK7 adrenergic beta receptor kinase 1 HUGO:ADRBK1 HGNC:289 ENTREZ:156 UNIPROT:P25098 GENECARDS:ADRBK1 REACTOME:50271 KEGG:156 ATLASONC:GC_ADRBK1 WIKI:ADRBK1 adrenergic beta receptor kinase 2 HUGO:ADRBK2 HGNC:290 ENTREZ:157 UNIPROT:P35626 GENECARDS:ADRBK2 KEGG:157 ATLASONC:GC_ADRBK2 WIKI:ADRBK2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK Maps_Modules_end References_begin: PMID:16525728 PMID:15618519 Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN. PMID:11226259 References_end</body> </html> </notes> <label text="GRK*"/> <bbox w="50.0" h="25.0" x="2215.0" y="1447.5"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s871_mpk1_mpk1_sa590"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: G protein-coupled receptor 1 HUGO:GPR1 HGNC:4463 ENTREZ:2825 UNIPROT:P46091 G protein-coupled receptor 3 HUGO:GPR3 HGNC:4484 ENTREZ:2827 UNIPROT:P46089 G protein-coupled receptor 4 HUGO:GPR4 HGNC:4497 ENTREZ:2828 UNIPROT:P46093 G protein-coupled receptor 6 HUGO:GPR6 HGNC:4515 ENTREZ:2830 UNIPROT:P46095 G protein-coupled receptor 12 HUGO:GPR12 HGNC:4466 ENTREZ:2835 UNIPROT:P47775 G protein-coupled receptor 15 HUGO:GPR15 HGNC:4469 ENTREZ:2838 UNIPROT:P49685 G protein-coupled receptor 17 HUGO:GPR17 HGNC:4471 ENTREZ:2840 UNIPROT:Q13304 G protein-coupled receptor 18 HUGO:GPR18 HGNC:4472 ENTREZ:2841 UNIPROT:Q14330 G protein-coupled receptor 19 HUGO:GPR19 HGNC:4473 ENTREZ:2842 UNIPROT:Q15760 G protein-coupled receptor 20 HUGO:GPR20 HGNC:4475 ENTREZ:2843 UNIPROT:Q99678 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Phosphorylation of GPCR (by GRK) induces the activation of ERK cascade on eary endosomes. PMID:19565474 References_end</body> </html> </notes> <label text="GPCR*"/> <bbox w="66.0" h="26.0" x="2207.0" y="1426.0"/> <glyph class="state variable" id="_73143b31-e5e4-4f28-89a7-6265ff6307f4"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2199.5" y="1434.0"/> </glyph> <glyph class="unit of information" id="_1f232837-f76b-4f36-bb05-8ef2221f48f2"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2217.5" y="1421.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s26_mpk1_mpk1_csa81" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ERN1:TRAF2 Identifiers_end</body> </html> </notes> <label text="ERN1:TRAF2"/> <bbox w="88.0" h="87.0" x="2895.9963" y="1498.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s28_mpk1_mpk1_sa455"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TNF receptor-associated factor 2 HUGO:TRAF2 HGNC:12032 ENTREZ:7186 UNIPROT:Q12933 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TRAF proteins are recruited to the TRADD-TNFR1 complex. TRADD couples TNFR1 to TRAF2. TRAF2 directly interacts with TNFR2. ERN1 activation is likely to trigger binding and activation of TRAF2. PMID:11274345 References_end</body> </html> </notes> <label text="TRAF2"/> <bbox w="50.0" h="25.0" x="2915.4963" y="1533.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s84_mpk1_mpk1_sa456"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: endoplasmic reticulum to nucleus signaling 1 "ER to nucleus signalling 1" HUGO:ERN1 HGNC:3449 ENTREZ:2081 UNIPROT:O75460 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ER stress lead to the oligomerisation and activation of mammalian Ire1p (ERN1). ERN1 activation is likely to trigger binding and activation of TRAF2. PMID:11274345 References_end</body> </html> </notes> <label text="ERN1"/> <bbox w="50.0" h="25.0" x="2916.4963" y="1506.0"/> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s982_mpk1_mpk1_csa33" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DAG:RASGRP1 Identifiers_end</body> </html> </notes> <label text="DAG:RASGRP1"/> <bbox w="103.0" h="82.0" x="379.0" y="1406.0"/> <glyph class="simple chemical" id="mpk1_mpk1_s293_mpk1_mpk1_sa178"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Diacylglycerol CAS:N/A PUBCHEM:3914 CHEBI:17815 KEGGCOMPOUND:C00165 Identifiers_end Maps_Modules_begin: MODULE:MAPK Maps_Modules_end References_begin: DAG activates the C1-domain of RasGRP1. PLCG acts on PIP2 in the PM to produce DAG and IP3. RasGRP1 is a C1-domain containing protein that is activated by DAG and Ca2+, in a manner analogous to members of the PKC family. PMID:17496910, PMID:16488589, PMID:17496910 DAG remains in the inner layer of the plasma membrane. It recruits Protein Kinase C (PKC) ??? a calcium-dependent kinase that phosphorylates many other proteins that bring about the changes in the cell. http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Second_messengers.html References_end</body> </html> </notes> <label text="DAG"/> <bbox w="70.0" h="25.0" x="394.0" y="1414.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s291_mpk1_mpk1_sa179"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAS guanyl releasing protein 1 (calcium and DAG-regulated) HUGO:RASGRP1 HGNC:9878 ENTREZ:10125 UNIPROT:O95267 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RasGRP1 specifically activates H-Ras in the Golgi. It is localised in the cytosol in quiescent cells. After PMA stimulus at first it moves to the PM and then shifts towards other subcellular compartments like the Golgi apparatus. RasGRP1 is a C1-domain containing protein that is activated by DAG and Ca2+ in a manner analogous to members of the PKC family. PMID:12782630 PMID:17496910 Activation of PKC: http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Second_messengers.html References_end</body> </html> </notes> <label text="RASGRP1"/> <bbox w="64.0" h="25.0" x="398.0" y="1439.0"/> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s988_mpk1_mpk1_csa34" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Ca2+:DAG:RASGRP1 Identifiers_end</body> </html> </notes> <label text="Ca2+:DAG:RASGRP1"/> <bbox w="141.0" h="85.0" x="449.5" y="1507.5"/> <glyph class="simple chemical" id="mpk1_mpk1_s890_mpk1_mpk1_sa181"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Diacylglycerol CAS:N/A PUBCHEM:3914 CHEBI:17815 KEGGCOMPOUND:C00165 Identifiers_end Maps_Modules_begin: MODULE:MAPK Maps_Modules_end References_begin: DAG activates the C1-domain of RasGRP1. PLCG acts on PIP2 in the PM to produce DAG and IP3. RasGRP1 is a C1-domain containing protein that is activated by DAG and Ca2+, in a manner analogous to members of the PKC family. PMID:17496910, PMID:16488589, PMID:17496910 DAG remains in the inner layer of the plasma membrane. It recruits Protein Kinase C (PKC) ??? a calcium-dependent kinase that phosphorylates many other proteins that bring about the changes in the cell. http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Second_messengers.html References_end</body> </html> </notes> <label text="DAG"/> <bbox w="70.0" h="25.0" x="496.5" y="1517.5"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s891_mpk1_mpk1_sa182"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAS guanyl releasing protein 1 (calcium and DAG-regulated) HUGO:RASGRP1 HGNC:9878 ENTREZ:10125 UNIPROT:O95267 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RasGRP1 specifically activates H-Ras in the Golgi. It is localised in the cytosol in quiescent cells. After PMA stimulus at first it moves to the PM and then shifts towards other subcellular compartments like the Golgi apparatus. RasGRP1 is a C1-domain containing protein that is activated by DAG and Ca2+ in a manner analogous to members of the PKC family. PMID:12782630 PMID:17496910 Activation of PKC: http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Second_messengers.html References_end</body> </html> </notes> <label text="RASGRP1"/> <bbox w="64.0" h="25.0" x="500.5" y="1542.5"/> </glyph> <glyph class="simple chemical" id="mpk1_mpk1_s892_mpk1_mpk1_sa273"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Ca2+ CAS:N/A PUBCHEM:N/A CHEBI:39124 KEGGCOMPOUND:N/A Identifiers_end References_begin: Calcium liberated from internal stores by IP3 acts on the calcium- and DAG-sensitive RasGRP1 and causes it to translocate to the Golgi. PMID:16488589 References_end</body> </html> </notes> <label text="Ca2+"/> <bbox w="61.0" h="38.0" x="455.0" y="1526.0"/> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1001_mpk1_mpk1_csa35" compartmentRef="mpk1_mpk1_c5_mpk1_mpk1_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Ca2+:DAG:RASGRP1 Identifiers_end</body> </html> </notes> <label text="Ca2+:DAG:RASGRP1"/> <bbox w="144.0" h="84.0" x="394.0" y="2135.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s838_mpk1_mpk1_sa185"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAS guanyl releasing protein 1 (calcium and DAG-regulated) HUGO:RASGRP1 HGNC:9878 ENTREZ:10125 UNIPROT:O95267 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RasGRP1 specifically activates H-Ras in the Golgi. It is localised in the cytosol in quiescent cells. After PMA stimulus at first it moves to the PM and then shifts towards other subcellular compartments like the Golgi apparatus. RasGRP1 is a C1-domain containing protein that is activated by DAG and Ca2+ in a manner analogous to members of the PKC family. PMID:12782630 PMID:17496910 Activation of PKC: http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Second_messengers.html References_end</body> </html> </notes> <label text="RASGRP1"/> <bbox w="64.0" h="25.0" x="450.0" y="2168.0"/> </glyph> <glyph class="simple chemical" id="mpk1_mpk1_s839_mpk1_mpk1_sa274"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Ca2+ CAS:N/A PUBCHEM:N/A CHEBI:39124 KEGGCOMPOUND:N/A Identifiers_end References_begin: Calcium liberated from internal stores by IP3 acts on the calcium- and DAG-sensitive RasGRP1 and causes it to translocate to the Golgi. PMID:16488589 References_end</body> </html> </notes> <label text="Ca2+"/> <bbox w="61.0" h="38.0" x="402.44446" y="2151.4443"/> </glyph> <glyph class="simple chemical" id="mpk1_mpk1_s837_mpk1_mpk1_sa600"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Generic_begin: DAG Generic_end References_begin: DAG activates the C1-domain of RasGRP1. PLCG acts on PIP2 in the PM to produce DAG and IP3. RasGRP1 is a C1-domain containing protein that is activated by DAG and Ca2+, in a manner analogous to members of the PKC family. PMID:17496910, PMID:16488589, PMID:17496910 DAG remains in the inner layer of the plasma membrane. It recruits Protein Kinase C (PKC) ??? a calcium-dependent kinase that phosphorylates many other proteins that bring about the changes in the cell. http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Second_messengers.html References_end</body> </html> </notes> <label text="DAG"/> <bbox w="70.0" h="25.0" x="446.125" y="2143.75"/> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s983_mpk1_mpk1_csa110" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Ca2+:DAG:PKC* Identifiers_end</body> </html> </notes> <label text="Ca2+:DAG:PKC*"/> <bbox w="117.0" h="91.0" x="560.0" y="1385.0"/> <glyph class="simple chemical" id="mpk1_mpk1_s935_mpk1_mpk1_sa688"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Diacylglycerol CAS:N/A PUBCHEM:3914 CHEBI:17815 KEGGCOMPOUND:C00165 Identifiers_end Maps_Modules_begin: MODULE:MAPK Maps_Modules_end References_begin: DAG activates the C1-domain of RasGRP1. PLCG acts on PIP2 in the PM to produce DAG and IP3. RasGRP1 is a C1-domain containing protein that is activated by DAG and Ca2+, in a manner analogous to members of the PKC family. PMID:17496910, PMID:16488589, PMID:17496910 DAG remains in the inner layer of the plasma membrane. It recruits Protein Kinase C (PKC) ??? a calcium-dependent kinase that phosphorylates many other proteins that bring about the changes in the cell. http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Second_messengers.html References_end</body> </html> </notes> <label text="DAG"/> <bbox w="70.0" h="25.0" x="600.0" y="1392.5"/> </glyph> <glyph class="simple chemical" id="mpk1_mpk1_s934_mpk1_mpk1_sa689"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Ca2+ CAS:N/A PUBCHEM:N/A CHEBI:39124 KEGGCOMPOUND:N/A Identifiers_end References_begin: Calcium liberated from internal stores by IP3 acts on the calcium- and DAG-sensitive RasGRP1 and causes it to translocate to the Golgi. PMID:16488589 References_end</body> </html> </notes> <label text="Ca2+"/> <bbox w="61.0" h="38.0" x="564.5" y="1406.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s936_mpk1_mpk1_sa690"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: protein kinase C alpha PKCA HUGO:PRKCA HGNC:9393 ENTREZ:5578 UNIPROT:P17252 protein kinase C beta PKCB PRKCB1 PRKCB2 "protein kinase C beta 1" HUGO:PRKCB HGNC:9395 ENTREZ:5579 UNIPROT:P05771 protein kinase C gamma PKCG SCA14 HUGO:PRKCG HGNC:9402 ENTREZ:5582 UNIPROT:P05129 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity. PMID:15567848 References_end Identifiers_begin: protein kinase C alpha PKCA HUGO:PRKCA HGNC:9393 ENTREZ:5578 UNIPROT:P17252 GENECARDS:PRKCA REACTOME:58197 KEGG:5578 ATLASONC:GC_PRKCA WIKI:PRKCA protein kinase C beta PKCB PRKCB1 PRKCB2 "protein kinase C beta 1" HUGO:PRKCB HGNC:9395 ENTREZ:5579 UNIPROT:P05771 GENECARDS:PRKCB REACTOME:58199 KEGG:5579 ATLASONC:GC_PRKCB WIKI:PRKCB protein kinase C gamma PKCG SCA14 HUGO:PRKCG HGNC:9402 ENTREZ:5582 UNIPROT:P05129 GENECARDS:PRKCG REACTOME:58205 KEGG:5582 ATLASONC:GC_PRKCG WIKI:PRKCG protein kinase C, delta HUGO:PRKCD HGNC:9399 ENTREZ:5580 UNIPROT:Q05655 GENECARDS:PRKCD REACTOME:58201 KEGG:5580 ATLASONC:PRKCDID42901ch3p21 WIKI:PRKCD protein kinase C, epsilon HUGO:PRKCE HGNC:9401 ENTREZ:5581 UNIPROT:Q02156 GENECARDS:PRKCE REACTOME:58203 KEGG:5581 ATLASONC:GC_PRKCE WIKI:PRKCE protein kinase C, eta HUGO:PRKCH HGNC:9403 ENTREZ:5583 UNIPROT:P24723 GENECARDS:PRKCH REACTOME:58209 KEGG:5583 ATLASONC:GC_PRKCH WIKI:PRKCH protein kinase C, iota HUGO:PRKCI HGNC:9404 ENTREZ:5584 UNIPROT:P41743 GENECARDS:PRKCI REACTOME:58207 KEGG:5584 ATLASONC:PRKCIID41857ch3q26 WIKI:PRKCI protein kinase C, theta HUGO:PRKCQ HGNC:9410 ENTREZ:5588 UNIPROT:Q04759 GENECARDS:PRKCQ REACTOME:58217 KEGG:5588 ATLASONC:GC_PRKCQ WIKI:PRKCQ Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity. PMID:15567848 PMID:11313945 PMID:11940581 Only PKC alpha and delta PMID:21386996 References_end</body> </html> Identifiers_begin: protein kinase C alpha PKCA HUGO:PRKCA HGNC:9393 ENTREZ:5578 UNIPROT:P17252 GENECARDS:PRKCA REACTOME:58197 KEGG:5578 ATLASONC:GC_PRKCA WIKI:PRKCA protein kinase C beta PKCB PRKCB1 PRKCB2 "protein kinase C beta 1" HUGO:PRKCB HGNC:9395 ENTREZ:5579 UNIPROT:P05771 GENECARDS:PRKCB REACTOME:58199 KEGG:5579 ATLASONC:GC_PRKCB WIKI:PRKCB protein kinase C gamma PKCG SCA14 HUGO:PRKCG HGNC:9402 ENTREZ:5582 UNIPROT:P05129 GENECARDS:PRKCG REACTOME:58205 KEGG:5582 ATLASONC:GC_PRKCG WIKI:PRKCG protein kinase C, delta HUGO:PRKCD HGNC:9399 ENTREZ:5580 UNIPROT:Q05655 GENECARDS:PRKCD REACTOME:58201 KEGG:5580 ATLASONC:PRKCDID42901ch3p21 WIKI:PRKCD protein kinase C, epsilon HUGO:PRKCE HGNC:9401 ENTREZ:5581 UNIPROT:Q02156 GENECARDS:PRKCE REACTOME:58203 KEGG:5581 ATLASONC:GC_PRKCE WIKI:PRKCE protein kinase C, eta HUGO:PRKCH HGNC:9403 ENTREZ:5583 UNIPROT:P24723 GENECARDS:PRKCH REACTOME:58209 KEGG:5583 ATLASONC:GC_PRKCH WIKI:PRKCH protein kinase C, iota HUGO:PRKCI HGNC:9404 ENTREZ:5584 UNIPROT:P41743 GENECARDS:PRKCI REACTOME:58207 KEGG:5584 ATLASONC:PRKCIID41857ch3q26 WIKI:PRKCI protein kinase C, theta HUGO:PRKCQ HGNC:9410 ENTREZ:5588 UNIPROT:Q04759 GENECARDS:PRKCQ REACTOME:58217 KEGG:5588 ATLASONC:GC_PRKCQ WIKI:PRKCQ Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity. PMID:15567848 PMID:11313945 PMID:11940581 Only PKC alpha and delta PMID:21386996 References_end</body> </html> </notes> <label text="PKC*"/> <bbox w="50.0" h="25.0" x="610.0" y="1418.5"/> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s993_mpk1_mpk1_csa4" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BRAF:GRB2:RAS*:RTK*:SOS* Identifiers_end</body> </html> </notes> <label text="BRAF:GRB2:RAS*:RTK*:SOS*"/> <bbox w="189.0" h="103.0" x="1430.0" y="1437.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s61_mpk1_mpk1_sa38"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 References_end Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 GENECARDS:GRB2 REACTOME:404631 KEGG:2885 ATLASONC:GRB2ID386ch17q25 WIKI:GRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="GRB2"/> <bbox w="50.0" h="25.0" x="1555.5" y="1469.75"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s756_mpk1_mpk1_sa39"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 References_end Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 GENECARDS:SOS1 REACTOME:64848 KEGG:6654 ATLASONC:GC_SOS1 WIKI:SOS1 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 GENECARDS:SOS2 REACTOME:64850 ATLASONC:GC_SOS2 WIKI:SOS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="SOS*"/> <bbox w="50.0" h="25.0" x="1555.5" y="1493.75"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s143_mpk1_mpk1_sa49"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: v-raf murine sarcoma viral oncogene homolog B1 HUGO:BRAF HGNC:1097 ENTREZ:673 UNIPROT:P15056 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: B-Raf is the MAPKKK for ERK cascade on plasma membrane. It is phosphorylated by RasGTP and phosphorylates MEK1/2 on plasma membrane. PMID:17496910 References_end</body> </html> </notes> <label text="BRAF"/> <bbox w="66.0" h="26.0" x="1446.5" y="1493.5"/> <glyph class="state variable" id="_9bedcf35-09ed-4d1b-aa2a-0cf26a648f40"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1439.0" y="1501.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s823_mpk1_mpk1_sa586"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> </notes> <label text="RTK*"/> <bbox w="50.0" h="25.0" x="1557.0" y="1448.0"/> <glyph class="state variable" id="_e1483822-40ad-4819-bf37-b1f63828f79c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1602.0" y="1460.6776"/> </glyph> <glyph class="state variable" id="_9cd1ec45-d732-4215-a82a-5e0d6e799fda"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1602.0" y="1460.6776"/> </glyph> <glyph class="state variable" id="_70bd4e99-44f8-405b-a22b-a1a85ecb75f0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1602.0" y="1455.5"/> </glyph> <glyph class="unit of information" id="_4f842124-f862-444c-ba7f-c1b399bb8e64"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="1559.5" y="1443.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s857_mpk1_mpk1_sa618"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> </notes> <label text="RAS*"/> <bbox w="50.0" h="25.0" x="1508.375" y="1493.0"/> <glyph class="state variable" id="_a7a5fb16-7a5b-49b4-aa91-e59196915259"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1500.875" y="1500.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s995_mpk1_mpk1_csa11" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BRAF:GRB2:KSR1:MEK*:RAS*:RTK*:SOS* Identifiers_end</body> </html> </notes> <label text="BRAF:GRB2:KSR1:MEK*:RAS*:RTK*:SOS*"/> <bbox w="259.0" h="168.0" x="1806.5" y="1405.5"/> <glyph class="macromolecule" id="mpk1_mpk1_s86_mpk1_mpk1_sa56"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 References_end Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 GENECARDS:GRB2 REACTOME:404631 KEGG:2885 ATLASONC:GRB2ID386ch17q25 WIKI:GRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="GRB2"/> <bbox w="50.0" h="25.0" x="1974.0" y="1437.25"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s87_mpk1_mpk1_sa57"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 References_end Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 GENECARDS:SOS1 REACTOME:64848 KEGG:6654 ATLASONC:GC_SOS1 WIKI:SOS1 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 GENECARDS:SOS2 REACTOME:64850 ATLASONC:GC_SOS2 WIKI:SOS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="SOS*"/> <bbox w="50.0" h="25.0" x="1974.0" y="1462.25"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s82_mpk1_mpk1_sa62"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: kinase suppressor of ras 1 "kinase suppressor of ras" KSR HUGO:KSR1 HGNC:6465 ENTREZ:8844 UNIPROT:Q8IVT5 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: KSR1 is a scaffold protein for ERK cascade. It normally localises in the cytosol but after GF treatment it moves to the plasma membrane. Its interaction with MEK1/2 is constitutive. Under endogenous conditions KSR1 facilitates the association of MEK and B-Raf (and not C-Raf) thus promoting MEK and ERK activation (on plasma membrane). PMID:19541618 References_end</body> </html> </notes> <label text="KSR1"/> <bbox w="41.0" h="77.0" x="1826.5" y="1463.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s83_mpk1_mpk1_sa63"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 1 PRKMK1 HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 mitogen-activated protein kinase kinase 2 PRKMK2 HUGO:MAP2K2 HGNC:6842 ENTREZ:5605 UNIPROT:P36507 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: In resting cells MEK1/2 are localised in the cytoplasm and this may be induced by two molecular mechanisms (i.e.: the presence of a nuclear export domain (NES) in their N-terminal domain; the binding to cytoplasmic anchors such as KSR MP1 beta-ARRESTIN-2 Sef1). MEK1 forms a complex with P14 and MP1 on late endosomes necessary for the activation of ERK pathway in this location of the cell. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19565474 PMID:17178906 PMID:15547943 References_end</body> </html> </notes> <label text="MEK*"/> <bbox w="66.0" h="26.0" x="1871.5" y="1488.0"/> <glyph class="state variable" id="_abc450e2-ee67-48c0-9912-6d8545dcde37"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1864.0" y="1500.333"/> </glyph> <glyph class="state variable" id="_79bea096-e819-4da9-873d-201e234cdea1"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1864.0" y="1491.451"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s144_mpk1_mpk1_sa59"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: v-raf murine sarcoma viral oncogene homolog B1 HUGO:BRAF HGNC:1097 ENTREZ:673 UNIPROT:P15056 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: B-Raf is the MAPKKK for ERK cascade on plasma membrane. It is phosphorylated by RasGTP and phosphorylates MEK1/2 on plasma membrane. PMID:17496910 References_end</body> </html> </notes> <label text="BRAF"/> <bbox w="66.0" h="26.0" x="1867.0" y="1463.0"/> <glyph class="state variable" id="_5932bf57-ff63-48bb-9c7e-5df3d0902257"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1859.5" y="1471.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s825_mpk1_mpk1_sa584"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> </notes> <label text="RTK*"/> <bbox w="50.0" h="25.0" x="1975.0" y="1416.0"/> <glyph class="state variable" id="_d425768b-9be7-4aec-adf4-013788532af8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2020.0" y="1428.6776"/> </glyph> <glyph class="state variable" id="_ab211c4d-a630-4aec-a65d-b71f826fd305"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2020.0" y="1428.6776"/> </glyph> <glyph class="state variable" id="_7da58891-5b76-4396-adc6-ead8450a9179"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2020.0" y="1423.5"/> </glyph> <glyph class="unit of information" id="_971f89c4-7241-492d-9d1f-906c789725db"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="1977.5" y="1411.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s88_mpk1_mpk1_sa620"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> </notes> <label text="RAS*"/> <bbox w="50.0" h="25.0" x="1926.125" y="1462.0"/> <glyph class="state variable" id="_5b353ab0-9077-4806-8409-e138c58ce5e6"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1918.625" y="1469.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s996_mpk1_mpk1_csa24" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BRAF:GRB2:KSR1-NTER*:RAS*:RTK*:SOS* Identifiers_end</body> </html> </notes> <label text="BRAF:GRB2:KSR1-NTER*:RAS*:RTK*:SOS*"/> <bbox w="257.0" h="135.0" x="1830.0" y="1614.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s207_mpk1_mpk1_sa125"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 References_end Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 GENECARDS:GRB2 REACTOME:404631 KEGG:2885 ATLASONC:GRB2ID386ch17q25 WIKI:GRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="GRB2"/> <bbox w="50.0" h="25.0" x="2006.5" y="1645.125"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s210_mpk1_mpk1_sa126"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 References_end Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 GENECARDS:SOS1 REACTOME:64848 KEGG:6654 ATLASONC:GC_SOS1 WIKI:SOS1 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 GENECARDS:SOS2 REACTOME:64850 ATLASONC:GC_SOS2 WIKI:SOS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="SOS*"/> <bbox w="50.0" h="25.0" x="2005.5" y="1669.125"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s209_mpk1_mpk1_sa128"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: v-raf murine sarcoma viral oncogene homolog B1 HUGO:BRAF HGNC:1097 ENTREZ:673 UNIPROT:P15056 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: B-Raf is the MAPKKK for ERK cascade on plasma membrane. It is phosphorylated by RasGTP and phosphorylates MEK1/2 on plasma membrane. PMID:17496910 References_end</body> </html> </notes> <label text="BRAF"/> <bbox w="66.0" h="26.0" x="1893.5" y="1669.875"/> <glyph class="state variable" id="_af14ec19-7cbe-4e2b-9625-fd300f45e879"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1886.0" y="1677.875"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s211_mpk1_mpk1_sa130"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: kinase suppressor of ras 1 "kinase suppressor of ras" KSR HUGO:KSR1 HGNC:6465 ENTREZ:8844 UNIPROT:Q8IVT5 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: KSR1 is cleaved by CASPASE3 in two regions: the C-ter region which mediates MEK binding and the N-ter region which contains the ERK binding site and the C1 domain required for plasma membrane localisation PMID:17613518 References_end</body> </html> </notes> <label text="KSR1-NTER*"/> <bbox w="116.0" h="25.0" x="1885.0" y="1695.0"/> <glyph class="unit of information" id="_47efb3d3-baaa-4d68-abb4-bb60a5afaa5a"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="1918.0" y="1690.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s827_mpk1_mpk1_sa588"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> </notes> <label text="RTK*"/> <bbox w="50.0" h="25.0" x="2007.1818" y="1624.0"/> <glyph class="state variable" id="_8f57c748-f60a-46b0-bcc4-e600fcca032c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2052.1816" y="1636.6776"/> </glyph> <glyph class="state variable" id="_f76d2919-7819-4940-8637-faeeb6620aca"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2052.1816" y="1636.6776"/> </glyph> <glyph class="state variable" id="_7fe8939b-d1c9-407c-85b0-908adfd6cb78"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2052.1816" y="1631.5"/> </glyph> <glyph class="unit of information" id="_d5580ccc-5268-4519-8c33-bcc0dbd648a5"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2009.6818" y="1619.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s208_mpk1_mpk1_sa632"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> </notes> <label text="RAS*"/> <bbox w="50.0" h="25.0" x="1957.125" y="1669.5"/> <glyph class="state variable" id="_ace4bd27-f7d3-4f6d-b751-b2d5a8d706a4"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1949.625" y="1677.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s994_mpk1_mpk1_csa12" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BRAF:ERK*:GRB2:KSR1:MEK*:RAS*:RTK*:SOS* Identifiers_end</body> </html> </notes> <label text="BRAF:ERK*:GRB2:KSR1:MEK*:RAS*:RTK*:SOS*"/> <bbox w="286.0" h="163.0" x="1391.5" y="1600.5"/> <glyph class="macromolecule" id="mpk1_mpk1_s866_mpk1_mpk1_sa621"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> </notes> <label text="RTK*"/> <bbox w="50.0" h="25.0" x="1591.625" y="1608.0"/> <glyph class="state variable" id="_9eff1389-7070-40bb-bbee-9b29ec90989b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1636.625" y="1620.6776"/> </glyph> <glyph class="state variable" id="_88988dbc-7411-4748-af35-01493b032f9e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1636.625" y="1620.6776"/> </glyph> <glyph class="state variable" id="_8ac615fe-2e98-44cd-8b03-184bc1504d1a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1636.625" y="1615.5"/> </glyph> <glyph class="unit of information" id="_46b80b94-be1e-4f6e-8ba0-d51c4dac3fdc"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="1594.125" y="1603.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s860_mpk1_mpk1_sa622"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 References_end Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 GENECARDS:GRB2 REACTOME:404631 KEGG:2885 ATLASONC:GRB2ID386ch17q25 WIKI:GRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="GRB2"/> <bbox w="50.0" h="25.0" x="1590.625" y="1629.25"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s861_mpk1_mpk1_sa623"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 References_end Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 GENECARDS:SOS1 REACTOME:64848 KEGG:6654 ATLASONC:GC_SOS1 WIKI:SOS1 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 GENECARDS:SOS2 REACTOME:64850 ATLASONC:GC_SOS2 WIKI:SOS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="SOS*"/> <bbox w="50.0" h="25.0" x="1590.625" y="1654.25"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s865_mpk1_mpk1_sa627"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: kinase suppressor of ras 1 "kinase suppressor of ras" KSR HUGO:KSR1 HGNC:6465 ENTREZ:8844 UNIPROT:Q8IVT5 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: KSR1 is a scaffold protein for ERK cascade. It normally localises in the cytosol but after GF treatment it moves to the plasma membrane. Its interaction with MEK1/2 is constitutive. Under endogenous conditions KSR1 facilitates the association of MEK and B-Raf (and not C-Raf) thus promoting MEK and ERK activation (on plasma membrane). PMID:19541618 References_end</body> </html> </notes> <label text="KSR1"/> <bbox w="41.0" h="77.0" x="1443.125" y="1655.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s867_mpk1_mpk1_sa628"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1 REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 GENECARDS:MAPK3 KEGG:5595 ATLASONC:MAPK3ID425ch16p11 WIKI:MAPK3 mitogen-activated protein kinase 4 HUGO:MAPK4 HGNC:6878 ENTREZ:5596 UNIPROT:P31152 GENECARDS:MAPK4 KEGG:5596 ATLASONC:MAPK4ID41293ch18q21 WIKI:MAPK4 mitogen-activated protein kinase 6 HUGO:MAPK6 HGNC:6879 ENTREZ:5597 UNIPROT:Q16659 GENECARDS:MAPK6 KEGG:5597 ATLASONC:MAPK6ID43349ch15q21 WIKI:MAPK6 ERK, ERK2, MAPK2, p41mapk Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end</body> </html> </notes> <label text="ERK*"/> <bbox w="66.0" h="26.0" x="1488.0" y="1705.75"/> <glyph class="state variable" id="_a40a3458-dea0-461e-af26-2d038a7c9c90"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1480.5" y="1718.2809"/> </glyph> <glyph class="state variable" id="_0e5a3efa-d8d2-4a10-9392-ba5a2c6ff1d4"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1480.5" y="1708.6022"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s868_mpk1_mpk1_sa629"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 1 PRKMK1 HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 mitogen-activated protein kinase kinase 2 PRKMK2 HUGO:MAP2K2 HGNC:6842 ENTREZ:5605 UNIPROT:P36507 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: In resting cells MEK1/2 are localised in the cytoplasm and this may be induced by two molecular mechanisms (i.e.: the presence of a nuclear export domain (NES) in their N-terminal domain; the binding to cytoplasmic anchors such as KSR MP1 beta-ARRESTIN-2 Sef1). MEK1 forms a complex with P14 and MP1 on late endosomes necessary for the activation of ERK pathway in this location of the cell. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19565474 PMID:17178906 PMID:15547943 References_end</body> </html> </notes> <label text="MEK*"/> <bbox w="66.0" h="26.0" x="1487.625" y="1681.25"/> <glyph class="state variable" id="_b79f96fb-47f0-4f08-8c54-e86fa9ab1874"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1480.125" y="1693.583"/> </glyph> <glyph class="state variable" id="_de176abb-e7f6-4110-9dd6-f1030fedd7b3"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1480.125" y="1684.701"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s869_mpk1_mpk1_sa630"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: v-raf murine sarcoma viral oncogene homolog B1 HUGO:BRAF HGNC:1097 ENTREZ:673 UNIPROT:P15056 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: B-Raf is the MAPKKK for ERK cascade on plasma membrane. It is phosphorylated by RasGTP and phosphorylates MEK1/2 on plasma membrane. PMID:17496910 References_end</body> </html> </notes> <label text="BRAF"/> <bbox w="66.0" h="26.0" x="1483.125" y="1656.25"/> <glyph class="state variable" id="_98f6f7ea-b30e-482d-a29d-f977db63ba9a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1475.625" y="1664.25"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s870_mpk1_mpk1_sa631"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> </notes> <label text="RAS*"/> <bbox w="50.0" h="25.0" x="1542.125" y="1655.0"/> <glyph class="state variable" id="_5742a898-0591-45a3-927a-56e12b3caf4e"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1534.625" y="1662.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s953_mpk1_mpk1_csa112" compartmentRef="mpk1_mpk1_c7_mpk1_mpk1_ca7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAD:BCL2 Identifiers_end</body> </html> </notes> <label text="BAD:BCL2"/> <bbox w="80.0" h="85.0" x="1177.0" y="1867.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s954_mpk1_mpk1_sa703"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 References_end Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end</body> </html> Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end</body> </html> </notes> <label text="BAD"/> <bbox w="50.0" h="25.0" x="1192.0" y="1879.5"/> <glyph class="state variable" id="_ac8f8ca4-2f77-417a-a3e5-65d262dd8b2e"> <state value="" variable="S112"/> <bbox w="30.0" h="10.0" x="1177.3079" y="1874.5"/> </glyph> <glyph class="state variable" id="_1340fb6c-6c64-4df8-9710-b16632532553"> <state value="" variable="S136"/> <bbox w="30.0" h="10.0" x="1227.0" y="1874.6343"/> </glyph> <glyph class="state variable" id="_8a29a6f6-0f50-438a-910f-6e8c3987ab10"> <state value="" variable="S155"/> <bbox w="30.0" h="10.0" x="1226.6136" y="1899.5"/> </glyph> <glyph class="state variable" id="_d042000c-3238-4732-91df-9140505db329"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1187.0" y="1887.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s955_mpk1_mpk1_sa704"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: BCL2 protein can target Raf-1 (C-Raf) to mitochondria. PMID:8929532 References_end</body> </html> </notes> <label text="BCL2"/> <bbox w="50.0" h="25.0" x="1192.0" y="1904.5"/> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s978_mpk1_mpk1_csa60" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MEK*:_beta_-Arrestin2* Identifiers_end</body> </html> </notes> <label text="MEK*:β-Arrestin2*"/> <bbox w="115.0" h="119.0" x="2683.0" y="1881.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s513_mpk1_mpk1_sa292"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="49.0" h="76.0" x="2746.0" y="1889.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s514_mpk1_mpk1_sa293"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 1 PRKMK1 HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 mitogen-activated protein kinase kinase 2 PRKMK2 HUGO:MAP2K2 HGNC:6842 ENTREZ:5605 UNIPROT:P36507 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: In resting cells MEK1/2 are localised in the cytoplasm and this may be induced by two molecular mechanisms (i.e.: the presence of a nuclear export domain (NES) in their N-terminal domain; the binding to cytoplasmic anchors such as KSR MP1 beta-ARRESTIN-2 Sef1). MEK1 forms a complex with P14 and MP1 on late endosomes necessary for the activation of ERK pathway in this location of the cell. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19565474 PMID:17178906 PMID:15547943 References_end</body> </html> </notes> <label text="MEK*"/> <bbox w="50.0" h="25.0" x="2698.0" y="1918.0"/> <glyph class="state variable" id="_a373f1f1-41b6-48e1-93e2-01c516601b97"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2693.0" y="1929.6664"/> </glyph> <glyph class="state variable" id="_4123112a-e14e-46b7-945d-4198d39c8cd8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2693.0" y="1921.1261"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s998_mpk1_mpk1_csa46" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GPCR*:GRK*:_beta_-Arrestin2* Identifiers_end</body> </html> </notes> <label text="GPCR*:GRK*:β-Arrestin2*"/> <bbox w="129.0" h="159.0" x="2228.0" y="1560.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s480_mpk1_mpk1_sa237"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="49.0" h="76.0" x="2269.0" y="1618.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s537_mpk1_mpk1_sa312"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adrenergic beta receptor kinase 1 HUGO:ADRBK1 HGNC:289 ENTREZ:156 UNIPROT:P25098 adrenergic beta receptor kinase 2 HUGO:ADRBK2 HGNC:290 ENTREZ:157 UNIPROT:P35626 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN. PMID:11226259 References_end Identifiers_begin: G protein-coupled receptor kinase 1 HUGO:GRK1 HGNC:10013 ENTREZ:6011 UNIPROT:Q15835 GENECARDS:GRK1 KEGG:6011 ATLASONC:GC_GRK1 WIKI:GRK1 G protein-coupled receptor kinase 4 HUGO:GRK4 HGNC:4543 ENTREZ:2868 UNIPROT:P32298 GENECARDS:GRK4 KEGG:2868 ATLASONC:GC_GRK4 WIKI:GRK4 G protein-coupled receptor kinase 5 HUGO:GRK5 HGNC:4544 ENTREZ:2869 UNIPROT:P34947 GENECARDS:GRK5 REACTOME:55956 KEGG:2869 WIKI:GRK5 G protein-coupled receptor kinase 6 HUGO:GRK6 HGNC:4545 ENTREZ:2870 UNIPROT:P43250 GENECARDS:GRK6 KEGG:2870 ATLASONC:GC_GRK6 WIKI:GRK6 G protein-coupled receptor kinase 7 HUGO:GRK7 HGNC:17031 ENTREZ:131890 UNIPROT:Q8WTQ7 GENECARDS:GRK7 KEGG:131890 WIKI:GRK7 adrenergic beta receptor kinase 1 HUGO:ADRBK1 HGNC:289 ENTREZ:156 UNIPROT:P25098 GENECARDS:ADRBK1 REACTOME:50271 KEGG:156 ATLASONC:GC_ADRBK1 WIKI:ADRBK1 adrenergic beta receptor kinase 2 HUGO:ADRBK2 HGNC:290 ENTREZ:157 UNIPROT:P35626 GENECARDS:ADRBK2 KEGG:157 ATLASONC:GC_ADRBK2 WIKI:ADRBK2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK Maps_Modules_end References_begin: PMID:16525728 PMID:15618519 Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN. PMID:11226259 References_end</body> </html> </notes> <label text="GRK*"/> <bbox w="50.0" h="25.0" x="2268.5" y="1591.3334"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s828_mpk1_mpk1_sa591"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: G protein-coupled receptor 1 HUGO:GPR1 HGNC:4463 ENTREZ:2825 UNIPROT:P46091 G protein-coupled receptor 3 HUGO:GPR3 HGNC:4484 ENTREZ:2827 UNIPROT:P46089 G protein-coupled receptor 4 HUGO:GPR4 HGNC:4497 ENTREZ:2828 UNIPROT:P46093 G protein-coupled receptor 6 HUGO:GPR6 HGNC:4515 ENTREZ:2830 UNIPROT:P46095 G protein-coupled receptor 12 HUGO:GPR12 HGNC:4466 ENTREZ:2835 UNIPROT:P47775 G protein-coupled receptor 15 HUGO:GPR15 HGNC:4469 ENTREZ:2838 UNIPROT:P49685 G protein-coupled receptor 17 HUGO:GPR17 HGNC:4471 ENTREZ:2840 UNIPROT:Q13304 G protein-coupled receptor 18 HUGO:GPR18 HGNC:4472 ENTREZ:2841 UNIPROT:Q14330 G protein-coupled receptor 19 HUGO:GPR19 HGNC:4473 ENTREZ:2842 UNIPROT:Q15760 G protein-coupled receptor 20 HUGO:GPR20 HGNC:4475 ENTREZ:2843 UNIPROT:Q99678 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Phosphorylation of GPCR (by GRK) induces the activation of ERK cascade on eary endosomes. PMID:19565474 References_end</body> </html> </notes> <label text="GPCR*"/> <bbox w="66.0" h="26.0" x="2260.0908" y="1568.0"/> <glyph class="state variable" id="_5ae55e27-8411-4a2b-ae2f-91e00b07429a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2252.5908" y="1576.0"/> </glyph> <glyph class="unit of information" id="_06657ec5-5cdc-4f32-b485-4668262f0d15"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2270.5908" y="1563.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s984_mpk1_mpk1_csa66" compartmentRef="mpk1_mpk1_c9_mpk1_mpk1_ca9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ERK*:MEK*:_beta_-Arrestin2* Identifiers_end</body> </html> </notes> <label text="ERK*:MEK*:β-Arrestin2*"/> <bbox w="146.0" h="119.0" x="2299.0" y="2122.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s550_mpk1_mpk1_sa319"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="49.0" h="77.0" x="2375.5" y="2132.3333"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s551_mpk1_mpk1_sa320"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 1 PRKMK1 HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 mitogen-activated protein kinase kinase 2 PRKMK2 HUGO:MAP2K2 HGNC:6842 ENTREZ:5605 UNIPROT:P36507 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: In resting cells MEK1/2 are localised in the cytoplasm and this may be induced by two molecular mechanisms (i.e.: the presence of a nuclear export domain (NES) in their N-terminal domain; the binding to cytoplasmic anchors such as KSR MP1 beta-ARRESTIN-2 Sef1). MEK1 forms a complex with P14 and MP1 on late endosomes necessary for the activation of ERK pathway in this location of the cell. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19565474 PMID:17178906 PMID:15547943 References_end</body> </html> </notes> <label text="MEK*"/> <bbox w="50.0" h="25.0" x="2326.5" y="2161.3333"/> <glyph class="state variable" id="_d5cba11a-e3aa-41b0-af2b-0bae5c1cfe7e"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2319.0" y="2172.9995"/> </glyph> <glyph class="state variable" id="_a9151b7d-5061-4283-a57c-47e7f1b49638"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2319.0" y="2164.4592"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s552_mpk1_mpk1_sa321"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1 REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 GENECARDS:MAPK3 KEGG:5595 ATLASONC:MAPK3ID425ch16p11 WIKI:MAPK3 mitogen-activated protein kinase 4 HUGO:MAPK4 HGNC:6878 ENTREZ:5596 UNIPROT:P31152 GENECARDS:MAPK4 KEGG:5596 ATLASONC:MAPK4ID41293ch18q21 WIKI:MAPK4 mitogen-activated protein kinase 6 HUGO:MAPK6 HGNC:6879 ENTREZ:5597 UNIPROT:Q16659 GENECARDS:MAPK6 KEGG:5597 ATLASONC:MAPK6ID43349ch15q21 WIKI:MAPK6 ERK, ERK2, MAPK2, p41mapk Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end</body> </html> </notes> <label text="ERK*"/> <bbox w="50.0" h="25.0" x="2326.5" y="2186.3333"/> <glyph class="state variable" id="_efcef904-7f4f-4261-b434-4d30a5352f99"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2319.0" y="2198.19"/> </glyph> <glyph class="state variable" id="_539630c2-0764-42cb-81bd-cef35d8384ea"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2319.0" y="2188.8833"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s985_mpk1_mpk1_csa67" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ERK*:MEK*:_beta_-Arrestin2* Identifiers_end</body> </html> </notes> <label text="ERK*:MEK*:β-Arrestin2*"/> <bbox w="140.0" h="116.0" x="2389.0" y="2306.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s803_mpk1_mpk1_sa560"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="49.0" h="77.0" x="2462.0" y="2314.2727"/> </glyph> <glyph class="macromolecule multimer" id="mpk1_mpk1_s804_mpk1_mpk1_sa561"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Modelling choices: - ERK represents both ERK1 and ERK2 because it is not completely clear when the two isoforms behave differently. This also happens for the activation on late endosomes: it is known that only ERK1 is activated there, however when ERK1 reaches nucleus, it behaves like ERK2. - Once activated, ERK may either keep being in complex with its activators and scaffolds, or be released in the cytoplasm. In the latter case, it may either dimerise, being able to activate its cytoplasmic targets, or not, being able to translocate to the nucleus. ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1 REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 GENECARDS:MAPK3 KEGG:5595 ATLASONC:MAPK3ID425ch16p11 WIKI:MAPK3 mitogen-activated protein kinase 4 HUGO:MAPK4 HGNC:6878 ENTREZ:5596 UNIPROT:P31152 GENECARDS:MAPK4 KEGG:5596 ATLASONC:MAPK4ID41293ch18q21 WIKI:MAPK4 mitogen-activated protein kinase 6 HUGO:MAPK6 HGNC:6879 ENTREZ:5597 UNIPROT:Q16659 GENECARDS:MAPK6 KEGG:5597 ATLASONC:MAPK6ID43349ch15q21 WIKI:MAPK6 ERK, ERK2, MAPK2, p41mapk Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end</body> </html> </notes> <label text="ERK*"/> <bbox w="50.0" h="25.0" x="2414.75" y="2369.7727"/> <glyph class="unit of information" id="_caba5678-c407-4e95-bf44-304415875034"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="2429.75" y="2364.7727"/> </glyph> <glyph class="state variable" id="_4e553ef9-0580-43b2-8c30-331c0dcbe10a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2407.25" y="2381.6294"/> </glyph> <glyph class="state variable" id="_1685e26d-bb19-4a32-8141-4904dc394645"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2407.25" y="2372.3228"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s805_mpk1_mpk1_sa563"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 1 PRKMK1 HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 mitogen-activated protein kinase kinase 2 PRKMK2 HUGO:MAP2K2 HGNC:6842 ENTREZ:5605 UNIPROT:P36507 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: In resting cells MEK1/2 are localised in the cytoplasm and this may be induced by two molecular mechanisms (i.e.: the presence of a nuclear export domain (NES) in their N-terminal domain; the binding to cytoplasmic anchors such as KSR MP1 beta-ARRESTIN-2 Sef1). MEK1 forms a complex with P14 and MP1 on late endosomes necessary for the activation of ERK pathway in this location of the cell. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19565474 PMID:17178906 PMID:15547943 References_end</body> </html> </notes> <label text="MEK*"/> <bbox w="50.0" h="25.0" x="2413.0417" y="2342.3862"/> <glyph class="state variable" id="_a23a6b35-fd8f-4413-803b-0befbeccc5a8"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2405.5417" y="2354.0525"/> </glyph> <glyph class="state variable" id="_b9dd0927-8266-4096-80c7-8d84540ee1ce"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2405.5417" y="2345.5122"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1002_mpk1_mpk1_csa37" compartmentRef="mpk1_mpk1_c5_mpk1_mpk1_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Ca2+:DAG:RAS*:RASGRP1 Identifiers_end</body> </html> </notes> <label text="Ca2+:DAG:RAS*:RASGRP1"/> <bbox w="181.0" h="110.0" x="187.5" y="2281.5"/> <glyph class="macromolecule" id="mpk1_mpk1_s483_mpk1_mpk1_sa195"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAS guanyl releasing protein 1 (calcium and DAG-regulated) HUGO:RASGRP1 HGNC:9878 ENTREZ:10125 UNIPROT:O95267 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RasGRP1 specifically activates H-Ras in the Golgi. It is localised in the cytosol in quiescent cells. After PMA stimulus at first it moves to the PM and then shifts towards other subcellular compartments like the Golgi apparatus. RasGRP1 is a C1-domain containing protein that is activated by DAG and Ca2+ in a manner analogous to members of the PKC family. PMID:12782630 PMID:17496910 Activation of PKC: http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Second_messengers.html References_end</body> </html> </notes> <label text="RASGRP1"/> <bbox w="64.0" h="25.0" x="251.0" y="2316.5"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s485_mpk1_mpk1_sa197"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> </notes> <label text="RAS*"/> <bbox w="50.0" h="25.0" x="267.0" y="2341.5"/> <glyph class="state variable" id="_f46703b5-214a-4029-99b4-da2e3c29cb62"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="259.5" y="2349.0"/> </glyph> </glyph> <glyph class="simple chemical" id="mpk1_mpk1_s489_mpk1_mpk1_sa276"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Ca2+ CAS:N/A PUBCHEM:N/A CHEBI:39124 KEGGCOMPOUND:N/A Identifiers_end References_begin: Calcium liberated from internal stores by IP3 acts on the calcium- and DAG-sensitive RasGRP1 and causes it to translocate to the Golgi. PMID:16488589 References_end</body> </html> </notes> <label text="Ca2+"/> <bbox w="61.0" h="38.0" x="203.44444" y="2299.2222"/> </glyph> <glyph class="simple chemical" id="mpk1_mpk1_s842_mpk1_mpk1_sa602"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DAG Identifiers_end References_begin: DAG activates the C1-domain of RasGRP1. PLCG acts on PIP2 in the PM to produce DAG and IP3. RasGRP1 is a C1-domain containing protein that is activated by DAG and Ca2+, in a manner analogous to members of the PKC family. PMID:17496910, PMID:16488589, PMID:17496910 DAG remains in the inner layer of the plasma membrane. It recruits Protein Kinase C (PKC) ??? a calcium-dependent kinase that phosphorylates many other proteins that bring about the changes in the cell. http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Second_messengers.html References_end</body> </html> </notes> <label text="DAG"/> <bbox w="70.0" h="25.0" x="249.125" y="2292.0"/> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1003_mpk1_mpk1_csa38" compartmentRef="mpk1_mpk1_c5_mpk1_mpk1_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Ca2+:DAG:RAF1:RAS*:RASGRP1 Identifiers_end</body> </html> </notes> <label text="Ca2+:DAG:RAF1:RAS*:RASGRP1"/> <bbox w="226.0" h="90.0" x="176.0" y="2525.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s321_mpk1_mpk1_sa206"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAS guanyl releasing protein 1 (calcium and DAG-regulated) HUGO:RASGRP1 HGNC:9878 ENTREZ:10125 UNIPROT:O95267 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RasGRP1 specifically activates H-Ras in the Golgi. It is localised in the cytosol in quiescent cells. After PMA stimulus at first it moves to the PM and then shifts towards other subcellular compartments like the Golgi apparatus. RasGRP1 is a C1-domain containing protein that is activated by DAG and Ca2+ in a manner analogous to members of the PKC family. PMID:12782630 PMID:17496910 Activation of PKC: http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Second_messengers.html References_end</body> </html> </notes> <label text="RASGRP1"/> <bbox w="64.0" h="25.0" x="243.5" y="2561.0"/> </glyph> <glyph class="simple chemical" id="mpk1_mpk1_s490_mpk1_mpk1_sa277"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Ca2+ CAS:N/A PUBCHEM:N/A CHEBI:39124 KEGGCOMPOUND:N/A Identifiers_end References_begin: Calcium liberated from internal stores by IP3 acts on the calcium- and DAG-sensitive RasGRP1 and causes it to translocate to the Golgi. PMID:16488589 References_end</body> </html> </notes> <label text="Ca2+"/> <bbox w="61.0" h="38.0" x="195.44444" y="2543.2222"/> </glyph> <glyph class="simple chemical" id="mpk1_mpk1_s320_mpk1_mpk1_sa601"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Generic_begin: DAG Generic_end References_begin: DAG activates the C1-domain of RasGRP1. PLCG acts on PIP2 in the PM to produce DAG and IP3. RasGRP1 is a C1-domain containing protein that is activated by DAG and Ca2+, in a manner analogous to members of the PKC family. PMID:17496910, PMID:16488589, PMID:17496910 DAG remains in the inner layer of the plasma membrane. It recruits Protein Kinase C (PKC) ??? a calcium-dependent kinase that phosphorylates many other proteins that bring about the changes in the cell. http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Second_messengers.html References_end</body> </html> </notes> <label text="DAG"/> <bbox w="70.0" h="25.0" x="239.125" y="2537.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s843_mpk1_mpk1_sa603"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> </notes> <label text="RAS*"/> <bbox w="50.0" h="25.0" x="311.375" y="2537.0"/> <glyph class="state variable" id="_74e30b57-ae43-435e-82f3-bfb5a6f1e544"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="303.875" y="2544.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s844_mpk1_mpk1_sa604"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: v-raf-1 murine leukemia viral oncogene homolog 1 HUGO:RAF1 HGNC:9829 ENTREZ:5894 UNIPROT:P04049 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Active KRas (on late endosomes) recruits Raf1 (C-Raf) to elicit a MODULE:MAPK signalling pathway. Raf1 MEK1/2 and ERK1/2 may act in the outer side of the Golgi apparatus and attenuate proliferation. PMID:19289794 PMID:19565474 References_end Identifiers_begin: v-raf-1 murine leukemia viral oncogene homolog 1 HUGO:RAF1 HGNC:9829 ENTREZ:5894 UNIPROT:P04049 GENECARDS:RAF1 REACTOME:58255 KEGG:5894 ATLASONC:RAF1ID42032ch3p25 WIKI:RAF1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Active KRas (on late endosomes) recruits Raf1 (C-Raf) to elicit a MODULE:MAPK signalling pathway. Raf1 MEK1/2 and ERK1/2 may act in the outer side of the Golgi apparatus and attenuate proliferation. PMID:19289794 PMID:19565474 References_end</body> </html> </notes> <label text="RAF1"/> <bbox w="66.0" h="26.0" x="309.375" y="2563.0"/> <glyph class="state variable" id="_95c288a1-a3ee-4469-8b75-f8f20eb3c62d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="301.875" y="2571.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1004_mpk1_mpk1_csa41" compartmentRef="mpk1_mpk1_c5_mpk1_mpk1_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ERK*:MEK*:SEF* Identifiers_end</body> </html> </notes> <label text="ERK*:MEK*:SEF*"/> <bbox w="112.0" h="87.0" x="425.0" y="2436.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s339_mpk1_mpk1_sa217"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: interleukin 17 receptor D HUGO:IL17RD HGNC:17616 ENTREZ:54756 UNIPROT:Q8NFM7 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Sef1 which is a putative transmembrane protein of the Golgi apparatus seems to be a scaffold protein that recruits ERK1/2 and MEK1/2 to its vicinity and probably allows their activation by Golgi-localised Ras proteins. Unlike many other scaffolds ERK1/2 do not dissociate from Sef1 upon stimulation and therefore nuclear translocation of the Sef1 anchored fraction of ERK1/2 molecules is blocked. PMID:19565474 PMID:19565474 References_end</body> </html> </notes> <label text="SEF*"/> <bbox w="50.0" h="25.0" x="436.875" y="2446.75"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s340_mpk1_mpk1_sa215"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 1 PRKMK1 HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 mitogen-activated protein kinase kinase 2 PRKMK2 HUGO:MAP2K2 HGNC:6842 ENTREZ:5605 UNIPROT:P36507 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: In resting cells MEK1/2 are localised in the cytoplasm and this may be induced by two molecular mechanisms (i.e.: the presence of a nuclear export domain (NES) in their N-terminal domain; the binding to cytoplasmic anchors such as KSR MP1 beta-ARRESTIN-2 Sef1). MEK1 forms a complex with P14 and MP1 on late endosomes necessary for the activation of ERK pathway in this location of the cell. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19565474 PMID:17178906 PMID:15547943 References_end</body> </html> </notes> <label text="MEK*"/> <bbox w="50.0" h="25.0" x="474.26135" y="2446.1592"/> <glyph class="state variable" id="_7b125ca8-26a3-491d-97a3-4024fa4013b9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="469.26135" y="2457.8254"/> </glyph> <glyph class="state variable" id="_c6d7a1f4-22c4-42ac-9b8b-24fc7248c93a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="469.26135" y="2449.2852"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s346_mpk1_mpk1_sa224"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1 REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 GENECARDS:MAPK3 KEGG:5595 ATLASONC:MAPK3ID425ch16p11 WIKI:MAPK3 mitogen-activated protein kinase 4 HUGO:MAPK4 HGNC:6878 ENTREZ:5596 UNIPROT:P31152 GENECARDS:MAPK4 KEGG:5596 ATLASONC:MAPK4ID41293ch18q21 WIKI:MAPK4 mitogen-activated protein kinase 6 HUGO:MAPK6 HGNC:6879 ENTREZ:5597 UNIPROT:Q16659 GENECARDS:MAPK6 KEGG:5597 ATLASONC:MAPK6ID43349ch15q21 WIKI:MAPK6 ERK, ERK2, MAPK2, p41mapk Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end</body> </html> </notes> <label text="ERK*"/> <bbox w="50.0" h="25.0" x="474.875" y="2471.75"/> <glyph class="state variable" id="_5f5a6d29-7887-4971-903a-c959036db6d7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="469.875" y="2483.6067"/> </glyph> <glyph class="state variable" id="_ac4e32fe-5748-49f9-acdd-d4ea5a60fba0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="469.875" y="2474.3"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1005_mpk1_mpk1_csa43" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ERK*:MEK*:SEF* Identifiers_end</body> </html> </notes> <label text="ERK*:MEK*:SEF*"/> <bbox w="126.0" h="87.0" x="677.0" y="2436.5"/> <glyph class="macromolecule" id="mpk1_mpk1_s343_mpk1_mpk1_sa221"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: interleukin 17 receptor D HUGO:IL17RD HGNC:17616 ENTREZ:54756 UNIPROT:Q8NFM7 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Sef1 which is a putative transmembrane protein of the Golgi apparatus seems to be a scaffold protein that recruits ERK1/2 and MEK1/2 to its vicinity and probably allows their activation by Golgi-localised Ras proteins. Unlike many other scaffolds ERK1/2 do not dissociate from Sef1 upon stimulation and therefore nuclear translocation of the Sef1 anchored fraction of ERK1/2 molecules is blocked. PMID:19565474 PMID:19565474 References_end</body> </html> </notes> <label text="SEF*"/> <bbox w="50.0" h="25.0" x="693.875" y="2445.25"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s344_mpk1_mpk1_sa222"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 1 PRKMK1 HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 mitogen-activated protein kinase kinase 2 PRKMK2 HUGO:MAP2K2 HGNC:6842 ENTREZ:5605 UNIPROT:P36507 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: In resting cells MEK1/2 are localised in the cytoplasm and this may be induced by two molecular mechanisms (i.e.: the presence of a nuclear export domain (NES) in their N-terminal domain; the binding to cytoplasmic anchors such as KSR MP1 beta-ARRESTIN-2 Sef1). MEK1 forms a complex with P14 and MP1 on late endosomes necessary for the activation of ERK pathway in this location of the cell. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19565474 PMID:17178906 PMID:15547943 References_end</body> </html> </notes> <label text="MEK*"/> <bbox w="50.0" h="25.0" x="730.26135" y="2445.6592"/> <glyph class="state variable" id="_0387c67c-4095-480e-8220-11ab5beb7304"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="722.76135" y="2457.3254"/> </glyph> <glyph class="state variable" id="_f9bfd5a4-8698-42ae-a0e2-8d42e1f7bdd6"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="722.76135" y="2448.7852"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s345_mpk1_mpk1_sa223"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1 REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 GENECARDS:MAPK3 KEGG:5595 ATLASONC:MAPK3ID425ch16p11 WIKI:MAPK3 mitogen-activated protein kinase 4 HUGO:MAPK4 HGNC:6878 ENTREZ:5596 UNIPROT:P31152 GENECARDS:MAPK4 KEGG:5596 ATLASONC:MAPK4ID41293ch18q21 WIKI:MAPK4 mitogen-activated protein kinase 6 HUGO:MAPK6 HGNC:6879 ENTREZ:5597 UNIPROT:Q16659 GENECARDS:MAPK6 KEGG:5597 ATLASONC:MAPK6ID43349ch15q21 WIKI:MAPK6 ERK, ERK2, MAPK2, p41mapk Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end</body> </html> </notes> <label text="ERK*"/> <bbox w="50.0" h="25.0" x="728.98865" y="2471.8408"/> <glyph class="state variable" id="_d11b153a-c373-48bb-a1e7-5111f4343efc"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="721.48865" y="2483.6975"/> </glyph> <glyph class="state variable" id="_d5846865-16d6-4d0b-8005-0ff2fd7720d5"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="721.48865" y="2474.3909"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1006_mpk1_mpk1_csa63" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ERK*:MEK*:SEF* Identifiers_end</body> </html> </notes> <label text="ERK*:MEK*:SEF*"/> <bbox w="126.0" h="89.0" x="697.0" y="2565.5"/> <glyph class="macromolecule" id="mpk1_mpk1_s533_mpk1_mpk1_sa308"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: interleukin 17 receptor D HUGO:IL17RD HGNC:17616 ENTREZ:54756 UNIPROT:Q8NFM7 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Sef1 which is a putative transmembrane protein of the Golgi apparatus seems to be a scaffold protein that recruits ERK1/2 and MEK1/2 to its vicinity and probably allows their activation by Golgi-localised Ras proteins. Unlike many other scaffolds ERK1/2 do not dissociate from Sef1 upon stimulation and therefore nuclear translocation of the Sef1 anchored fraction of ERK1/2 molecules is blocked. PMID:19565474 PMID:19565474 References_end</body> </html> </notes> <label text="SEF*"/> <bbox w="66.0" h="26.0" x="717.5" y="2575.8335"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s534_mpk1_mpk1_sa309"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 1 PRKMK1 HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 mitogen-activated protein kinase kinase 2 PRKMK2 HUGO:MAP2K2 HGNC:6842 ENTREZ:5605 UNIPROT:P36507 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: In resting cells MEK1/2 are localised in the cytoplasm and this may be induced by two molecular mechanisms (i.e.: the presence of a nuclear export domain (NES) in their N-terminal domain; the binding to cytoplasmic anchors such as KSR MP1 beta-ARRESTIN-2 Sef1). MEK1 forms a complex with P14 and MP1 on late endosomes necessary for the activation of ERK pathway in this location of the cell. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19565474 PMID:17178906 PMID:15547943 References_end</body> </html> </notes> <label text="MEK*"/> <bbox w="66.0" h="26.0" x="753.5" y="2577.8335"/> <glyph class="state variable" id="_af469740-e1e1-4791-8034-45b4ea5811d0"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="746.0" y="2590.1665"/> </glyph> <glyph class="state variable" id="_48e30b55-e367-4de8-b272-0ea8ecdcb26e"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="746.0" y="2581.2847"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="mpk1_mpk1_s535_mpk1_mpk1_sa310"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Modelling choices: - ERK represents both ERK1 and ERK2 because it is not completely clear when the two isoforms behave differently. This also happens for the activation on late endosomes: it is known that only ERK1 is activated there, however when ERK1 reaches nucleus, it behaves like ERK2. - Once activated, ERK may either keep being in complex with its activators and scaffolds, or be released in the cytoplasm. In the latter case, it may either dimerise, being able to activate its cytoplasmic targets, or not, being able to translocate to the nucleus. ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1 REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 GENECARDS:MAPK3 KEGG:5595 ATLASONC:MAPK3ID425ch16p11 WIKI:MAPK3 mitogen-activated protein kinase 4 HUGO:MAPK4 HGNC:6878 ENTREZ:5596 UNIPROT:P31152 GENECARDS:MAPK4 KEGG:5596 ATLASONC:MAPK4ID41293ch18q21 WIKI:MAPK4 mitogen-activated protein kinase 6 HUGO:MAPK6 HGNC:6879 ENTREZ:5597 UNIPROT:Q16659 GENECARDS:MAPK6 KEGG:5597 ATLASONC:MAPK6ID43349ch15q21 WIKI:MAPK6 ERK, ERK2, MAPK2, p41mapk Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end</body> </html> </notes> <label text="ERK*"/> <bbox w="66.0" h="26.0" x="753.9167" y="2603.3335"/> <glyph class="unit of information" id="_2233a7b4-a468-4b92-8594-550d194c07f6"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="776.9167" y="2598.3335"/> </glyph> <glyph class="state variable" id="_10000386-760f-4a04-8f59-e8d7690e1590"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="746.4167" y="2615.8645"/> </glyph> <glyph class="state variable" id="_8b1ea434-92e9-4659-9e6c-f47562f7afe8"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="746.4167" y="2606.1855"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1007_mpk1_mpk1_csa58" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MEK*:SEF* Identifiers_end</body> </html> </notes> <label text="MEK*:SEF*"/> <bbox w="104.0" h="93.0" x="633.0" y="2157.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s802_mpk1_mpk1_sa558"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: interleukin 17 receptor D HUGO:IL17RD HGNC:17616 ENTREZ:54756 UNIPROT:Q8NFM7 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Sef1 which is a putative transmembrane protein of the Golgi apparatus seems to be a scaffold protein that recruits ERK1/2 and MEK1/2 to its vicinity and probably allows their activation by Golgi-localised Ras proteins. Unlike many other scaffolds ERK1/2 do not dissociate from Sef1 upon stimulation and therefore nuclear translocation of the Sef1 anchored fraction of ERK1/2 molecules is blocked. PMID:19565474 PMID:19565474 References_end</body> </html> </notes> <label text="SEF*"/> <bbox w="37.0" h="58.0" x="640.2727" y="2168.318"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s855_mpk1_mpk1_sa617"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 1 PRKMK1 HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 mitogen-activated protein kinase kinase 2 PRKMK2 HUGO:MAP2K2 HGNC:6842 ENTREZ:5605 UNIPROT:P36507 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: In resting cells MEK1/2 are localised in the cytoplasm and this may be induced by two molecular mechanisms (i.e.: the presence of a nuclear export domain (NES) in their N-terminal domain; the binding to cytoplasmic anchors such as KSR MP1 beta-ARRESTIN-2 Sef1). MEK1 forms a complex with P14 and MP1 on late endosomes necessary for the activation of ERK pathway in this location of the cell. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19565474 PMID:17178906 PMID:15547943 References_end</body> </html> </notes> <label text="MEK*"/> <bbox w="37.0" h="58.0" x="678.625" y="2168.0"/> <glyph class="state variable" id="_e88b8d87-7898-4a5a-9481-405d4e58e863"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="673.625" y="2201.666"/> </glyph> <glyph class="state variable" id="_e3093863-b16a-4bb9-a59e-ba894a1cb120"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="673.625" y="2181.8525"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1008_mpk1_mpk1_csa113" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GAB1:GRB2 Identifiers_end</body> </html> </notes> <label text="GAB1:GRB2"/> <bbox w="80.0" h="84.0" x="706.5" y="1997.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s970_mpk1_mpk1_sa713"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 References_end Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 GENECARDS:GRB2 REACTOME:404631 KEGG:2885 ATLASONC:GRB2ID386ch17q25 WIKI:GRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="GRB2"/> <bbox w="50.0" h="25.0" x="725.5" y="2005.5"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s971_mpk1_mpk1_sa714"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: GRB2-associated binding protein 1 HUGO:GAB1 HGNC:4066 ENTREZ:2549 UNIPROT:Q13480 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: GRB2-associated binding protein 1 HUGO:GAB1 HGNC:4066 ENTREZ:2549 UNIPROT:Q13480 GENECARDS:GAB1 REACTOME:147726 ATLASONC:GC_GAB1 WIKI:GAB1 GRB2-associated binding protein 2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11313945 PMID:11940581 References_end</body> </html> </notes> <label text="GAB1"/> <bbox w="50.0" h="25.0" x="725.5" y="2030.5"/> <glyph class="state variable" id="_8d860e18-294b-4d55-9bfe-2cc5ac05ace1"> <state value="" variable="Y977"/> <bbox w="30.0" h="10.0" x="710.8078" y="2025.5"/> </glyph> <glyph class="state variable" id="_9b795641-6ebf-4850-9e34-3d23151a0b7d"> <state value="" variable="Y989"/> <bbox w="30.0" h="10.0" x="760.5" y="2025.6343"/> </glyph> <glyph class="state variable" id="_412cad16-c048-4108-9f3f-4393ca23ba42"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="718.0" y="2038.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1009_mpk1_mpk1_csa21" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GRB2:SOS* Identifiers_end</body> </html> </notes> <label text="GRB2:SOS*"/> <bbox w="75.0" h="84.0" x="620.5" y="1842.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s35_mpk1_mpk1_sa23"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 References_end Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 GENECARDS:GRB2 REACTOME:404631 KEGG:2885 ATLASONC:GRB2ID386ch17q25 WIKI:GRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="GRB2"/> <bbox w="50.0" h="25.0" x="633.5" y="1852.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s762_mpk1_mpk1_sa25"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 References_end Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 GENECARDS:SOS1 REACTOME:64848 KEGG:6654 ATLASONC:GC_SOS1 WIKI:SOS1 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 GENECARDS:SOS2 REACTOME:64850 ATLASONC:GC_SOS2 WIKI:SOS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="SOS*"/> <bbox w="50.0" h="25.0" x="633.5" y="1877.0"/> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1010_mpk1_mpk1_csa111" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GAB1:GRB2 Identifiers_end</body> </html> </notes> <label text="GAB1:GRB2"/> <bbox w="80.0" h="84.0" x="897.0" y="1832.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s967_mpk1_mpk1_sa693"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 References_end Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 GENECARDS:GRB2 REACTOME:404631 KEGG:2885 ATLASONC:GRB2ID386ch17q25 WIKI:GRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="GRB2"/> <bbox w="50.0" h="25.0" x="916.0" y="1840.5"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s968_mpk1_mpk1_sa694"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: GRB2-associated binding protein 1 HUGO:GAB1 HGNC:4066 ENTREZ:2549 UNIPROT:Q13480 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: GRB2-associated binding protein 1 HUGO:GAB1 HGNC:4066 ENTREZ:2549 UNIPROT:Q13480 GENECARDS:GAB1 REACTOME:147726 ATLASONC:GC_GAB1 WIKI:GAB1 GRB2-associated binding protein 2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11313945 PMID:11940581 References_end</body> </html> </notes> <label text="GAB1"/> <bbox w="50.0" h="25.0" x="916.0" y="1865.5"/> <glyph class="state variable" id="_9f0f0886-9e42-4296-9742-6091ecd466c0"> <state value="" variable="Y977"/> <bbox w="30.0" h="10.0" x="901.3078" y="1860.5"/> </glyph> <glyph class="state variable" id="_6f8e484a-dd6a-4e7f-a380-90f489765ded"> <state value="" variable="Y989"/> <bbox w="30.0" h="10.0" x="951.0" y="1860.6343"/> </glyph> <glyph class="state variable" id="_94a016a3-2efc-4739-b377-2fa9c6ae3bf0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="911.0" y="1873.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1011_mpk1_mpk1_csa14" compartmentRef="mpk1_mpk1_c3_mpk1_mpk1_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:LAMTOR2:MP1* Identifiers_end</body> </html> </notes> <label text="LAMTOR2:MP1*"/> <bbox w="119.0" h="98.0" x="1223.0" y="2254.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s118_mpk1_mpk1_sa73"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: late endosomal/lysosomal adaptor MODULE:MAPK and MTOR activator 3 MAP2K1IP1 "MODULE:MAPK scaffold protein 1" MAPKSP1 "mitogen-activated protein kinase kinase 1 interacting protein 1" HUGO:LAMTOR3 HGNC:15606 ENTREZ:8649 UNIPROT:Q9UHA4 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MP1 is localised in late endosomes by P14 forming a very stable heterodimeric complex that is required for ERK activation. It is required for efficient and sustained EGF-induced MEK and ERK activation (in late endosomes) PMID:17178906 References_end</body> </html> </notes> <label text="MP1*"/> <bbox w="50.0" h="25.0" x="1233.0" y="2264.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s923_mpk1_mpk1_sa74"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: late endosomal/lysosomal adaptor MODULE:MAPK and MTOR activator 2 "roadblock domain containing 3" ROBLD3 HUGO:LAMTOR2 HGNC:29796 ENTREZ:28956 UNIPROT:Q9Y2Q5 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: P14 is an adaptor protein responsible for the recruitment of MP1 to late endosomes. P14 is peripherally associated with the cytoplasmic face of late endosomes. PMID:17178906 PMID:12479806 References_end</body> </html> </notes> <label text="LAMTOR2"/> <bbox w="66.0" h="26.0" x="1266.0" y="2284.0"/> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1012_mpk1_mpk1_csa15" compartmentRef="mpk1_mpk1_c3_mpk1_mpk1_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:LAMTOR2:MEK*:MP1* Identifiers_end</body> </html> </notes> <label text="LAMTOR2:MEK*:MP1*"/> <bbox w="158.0" h="99.0" x="1207.0" y="2371.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s392_mpk1_mpk1_sa265"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 1 PRKMK1 HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 mitogen-activated protein kinase kinase 2 PRKMK2 HUGO:MAP2K2 HGNC:6842 ENTREZ:5605 UNIPROT:P36507 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: In resting cells MEK1/2 are localised in the cytoplasm and this may be induced by two molecular mechanisms (i.e.: the presence of a nuclear export domain (NES) in their N-terminal domain; the binding to cytoplasmic anchors such as KSR MP1 beta-ARRESTIN-2 Sef1). MEK1 forms a complex with P14 and MP1 on late endosomes necessary for the activation of ERK pathway in this location of the cell. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19565474 PMID:17178906 PMID:15547943 References_end</body> </html> </notes> <label text="MEK*"/> <bbox w="50.0" h="25.0" x="1223.8334" y="2401.1665"/> <glyph class="state variable" id="_2860d97b-a2c6-4c0d-833c-01b30d4c3e5c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1218.8334" y="2412.8328"/> </glyph> <glyph class="state variable" id="_6fc655ea-5710-4125-844d-4cf3348401f1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1218.8334" y="2404.2925"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s854_mpk1_mpk1_sa615"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: late endosomal/lysosomal adaptor MODULE:MAPK and MTOR activator 3 MAP2K1IP1 "MODULE:MAPK scaffold protein 1" MAPKSP1 "mitogen-activated protein kinase kinase 1 interacting protein 1" HUGO:LAMTOR3 HGNC:15606 ENTREZ:8649 UNIPROT:Q9UHA4 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MP1 is localised in late endosomes by P14 forming a very stable heterodimeric complex that is required for ERK activation. It is required for efficient and sustained EGF-induced MEK and ERK activation (in late endosomes) PMID:17178906 References_end</body> </html> </notes> <label text="MP1*"/> <bbox w="33.0" h="66.0" x="1270.875" y="2380.5"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s853_mpk1_mpk1_sa616"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: late endosomal/lysosomal adaptor MODULE:MAPK and MTOR activator 2 "roadblock domain containing 3" ROBLD3 HUGO:LAMTOR2 HGNC:29796 ENTREZ:28956 UNIPROT:Q9Y2Q5 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: P14 is an adaptor protein responsible for the recruitment of MP1 to late endosomes. P14 is peripherally associated with the cytoplasmic face of late endosomes. PMID:17178906 PMID:12479806 References_end</body> </html> </notes> <label text="LAMTOR2"/> <bbox w="56.125" h="27.5" x="1303.875" y="2399.0"/> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1013_mpk1_mpk1_csa16" compartmentRef="mpk1_mpk1_c3_mpk1_mpk1_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GRB2:LAMTOR2:MEK*:MP1*:RAS*:RTK*:SOS* Identifiers_end</body> </html> </notes> <label text="GRB2:LAMTOR2:MEK*:MP1*:RAS*:RTK*:SOS*"/> <bbox w="276.0" h="152.0" x="906.0" y="2248.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s123_mpk1_mpk1_sa83"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 References_end Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 GENECARDS:GRB2 REACTOME:404631 KEGG:2885 ATLASONC:GRB2ID386ch17q25 WIKI:GRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="GRB2"/> <bbox w="50.0" h="25.0" x="1079.5" y="2282.75"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s124_mpk1_mpk1_sa84"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 References_end Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 GENECARDS:SOS1 REACTOME:64848 KEGG:6654 ATLASONC:GC_SOS1 WIKI:SOS1 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 GENECARDS:SOS2 REACTOME:64850 ATLASONC:GC_SOS2 WIKI:SOS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="SOS*"/> <bbox w="50.0" h="25.0" x="1080.5" y="2307.75"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s128_mpk1_mpk1_sa86"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: late endosomal/lysosomal adaptor MODULE:MAPK and MTOR activator 2 "roadblock domain containing 3" ROBLD3 HUGO:LAMTOR2 HGNC:29796 ENTREZ:28956 UNIPROT:Q9Y2Q5 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: P14 is an adaptor protein responsible for the recruitment of MP1 to late endosomes. P14 is peripherally associated with the cytoplasmic face of late endosomes. PMID:17178906 PMID:12479806 References_end</body> </html> </notes> <label text="LAMTOR2"/> <bbox w="64.25" h="23.5" x="1037.75" y="2334.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s126_mpk1_mpk1_sa87"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: late endosomal/lysosomal adaptor MODULE:MAPK and MTOR activator 3 MAP2K1IP1 "MODULE:MAPK scaffold protein 1" MAPKSP1 "mitogen-activated protein kinase kinase 1 interacting protein 1" HUGO:LAMTOR3 HGNC:15606 ENTREZ:8649 UNIPROT:Q9UHA4 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MP1 is localised in late endosomes by P14 forming a very stable heterodimeric complex that is required for ERK activation. It is required for efficient and sustained EGF-induced MEK and ERK activation (in late endosomes) PMID:17178906 References_end</body> </html> </notes> <label text="MP1*"/> <bbox w="50.0" h="25.0" x="995.0" y="2287.5"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s393_mpk1_mpk1_sa266"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 1 PRKMK1 HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 mitogen-activated protein kinase kinase 2 PRKMK2 HUGO:MAP2K2 HGNC:6842 ENTREZ:5605 UNIPROT:P36507 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: In resting cells MEK1/2 are localised in the cytoplasm and this may be induced by two molecular mechanisms (i.e.: the presence of a nuclear export domain (NES) in their N-terminal domain; the binding to cytoplasmic anchors such as KSR MP1 beta-ARRESTIN-2 Sef1). MEK1 forms a complex with P14 and MP1 on late endosomes necessary for the activation of ERK pathway in this location of the cell. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19565474 PMID:17178906 PMID:15547943 References_end</body> </html> </notes> <label text="MEK*"/> <bbox w="50.0" h="25.0" x="954.5" y="2330.1665"/> <glyph class="state variable" id="_b8f96bde-a663-4375-8860-977bbaf55444"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="949.5" y="2341.8328"/> </glyph> <glyph class="state variable" id="_79eb56d0-014f-4cf1-be31-88903af728ee"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="949.5" y="2333.2925"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s817_mpk1_mpk1_sa579"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> </notes> <label text="RTK*"/> <bbox w="50.0" h="25.0" x="1079.8181" y="2260.4546"/> <glyph class="state variable" id="_ec560b87-bb25-4ef6-9d8c-f3c41a955c1a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1124.8181" y="2273.1323"/> </glyph> <glyph class="state variable" id="_9ef2ad7b-cb09-4e9b-abad-5c6965516ac3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1124.8181" y="2273.1323"/> </glyph> <glyph class="state variable" id="_e5cf7d46-2d20-4f79-96a8-0f2cde457225"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1124.8181" y="2267.9546"/> </glyph> <glyph class="unit of information" id="_d6ba358f-6aa6-4cd9-aa93-454b36bbd6e3"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="1082.3181" y="2255.4546"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s845_mpk1_mpk1_sa605"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> </notes> <label text="RAS*"/> <bbox w="50.0" h="25.0" x="1037.125" y="2307.0"/> <glyph class="state variable" id="_dedc3310-3661-43ac-bed6-714b7660f9aa"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1029.625" y="2314.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1014_mpk1_mpk1_csa18" compartmentRef="mpk1_mpk1_c3_mpk1_mpk1_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GRB2:LAMTOR2:MEK*:MP1*:RAF1:RAS*:RTK*:SOS* Identifiers_end</body> </html> </notes> <label text="GRB2:LAMTOR2:MEK*:MP1*:RAF1:RAS*:RTK*:SOS*"/> <bbox w="312.0" h="146.0" x="904.5" y="2537.5"/> <glyph class="macromolecule" id="mpk1_mpk1_s160_mpk1_mpk1_sa101"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: v-raf-1 murine leukemia viral oncogene homolog 1 HUGO:RAF1 HGNC:9829 ENTREZ:5894 UNIPROT:P04049 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Active KRas (on late endosomes) recruits Raf1 (C-Raf) to elicit a MODULE:MAPK signalling pathway. Raf1 MEK1/2 and ERK1/2 may act in the outer side of the Golgi apparatus and attenuate proliferation. PMID:19289794 PMID:19565474 References_end Identifiers_begin: v-raf-1 murine leukemia viral oncogene homolog 1 HUGO:RAF1 HGNC:9829 ENTREZ:5894 UNIPROT:P04049 GENECARDS:RAF1 REACTOME:58255 KEGG:5894 ATLASONC:RAF1ID42032ch3p25 WIKI:RAF1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Active KRas (on late endosomes) recruits Raf1 (C-Raf) to elicit a MODULE:MAPK signalling pathway. Raf1 MEK1/2 and ERK1/2 may act in the outer side of the Golgi apparatus and attenuate proliferation. PMID:19289794 PMID:19565474 References_end</body> </html> </notes> <label text="RAF1"/> <bbox w="66.0" h="26.0" x="969.5" y="2591.5"/> <glyph class="state variable" id="_b0ac8615-9c96-4cf6-9b3e-2eb6bed79906"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="962.0" y="2599.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s396_mpk1_mpk1_sa267"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 1 PRKMK1 HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 mitogen-activated protein kinase kinase 2 PRKMK2 HUGO:MAP2K2 HGNC:6842 ENTREZ:5605 UNIPROT:P36507 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: In resting cells MEK1/2 are localised in the cytoplasm and this may be induced by two molecular mechanisms (i.e.: the presence of a nuclear export domain (NES) in their N-terminal domain; the binding to cytoplasmic anchors such as KSR MP1 beta-ARRESTIN-2 Sef1). MEK1 forms a complex with P14 and MP1 on late endosomes necessary for the activation of ERK pathway in this location of the cell. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19565474 PMID:17178906 PMID:15547943 References_end</body> </html> </notes> <label text="MEK*"/> <bbox w="66.0" h="26.0" x="970.5" y="2616.8335"/> <glyph class="state variable" id="_c001f9ce-0698-44eb-abc3-2b2e9e9be700"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="963.0" y="2629.1665"/> </glyph> <glyph class="state variable" id="_aff9846e-c6a0-4517-879a-91d3e243a3bd"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="963.0" y="2620.2847"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s846_mpk1_mpk1_sa606"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> </notes> <label text="RTK*"/> <bbox w="50.0" h="25.0" x="1095.4432" y="2545.9773"/> <glyph class="state variable" id="_d78f204c-63ea-40bc-a3ab-4defc482eea7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1140.4432" y="2558.655"/> </glyph> <glyph class="state variable" id="_20002ee2-2ddd-4ae9-b279-f7c458a1f221"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1140.4432" y="2558.655"/> </glyph> <glyph class="state variable" id="_c0a5d43b-a167-4e8e-b438-c5d279811394"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1140.4432" y="2553.4773"/> </glyph> <glyph class="unit of information" id="_b8d1baa1-af7e-4335-873d-6aa70158fa15"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="1097.9432" y="2540.9773"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s847_mpk1_mpk1_sa607"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 References_end Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 GENECARDS:GRB2 REACTOME:404631 KEGG:2885 ATLASONC:GRB2ID386ch17q25 WIKI:GRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="GRB2"/> <bbox w="50.0" h="25.0" x="1095.125" y="2568.2727"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s848_mpk1_mpk1_sa608"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 References_end Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 GENECARDS:SOS1 REACTOME:64848 KEGG:6654 ATLASONC:GC_SOS1 WIKI:SOS1 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 GENECARDS:SOS2 REACTOME:64850 ATLASONC:GC_SOS2 WIKI:SOS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="SOS*"/> <bbox w="50.0" h="25.0" x="1096.125" y="2593.2727"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s850_mpk1_mpk1_sa610"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: late endosomal/lysosomal adaptor MODULE:MAPK and MTOR activator 2 "roadblock domain containing 3" ROBLD3 HUGO:LAMTOR2 HGNC:29796 ENTREZ:28956 UNIPROT:Q9Y2Q5 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: P14 is an adaptor protein responsible for the recruitment of MP1 to late endosomes. P14 is peripherally associated with the cytoplasmic face of late endosomes. PMID:17178906 PMID:12479806 References_end</body> </html> </notes> <label text="LAMTOR2"/> <bbox w="58.625" h="25.977272" x="1053.375" y="2618.0227"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s851_mpk1_mpk1_sa611"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: late endosomal/lysosomal adaptor MODULE:MAPK and MTOR activator 3 MAP2K1IP1 "MODULE:MAPK scaffold protein 1" MAPKSP1 "mitogen-activated protein kinase kinase 1 interacting protein 1" HUGO:LAMTOR3 HGNC:15606 ENTREZ:8649 UNIPROT:Q9UHA4 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MP1 is localised in late endosomes by P14 forming a very stable heterodimeric complex that is required for ERK activation. It is required for efficient and sustained EGF-induced MEK and ERK activation (in late endosomes) PMID:17178906 References_end</body> </html> </notes> <label text="MP1*"/> <bbox w="66.0" h="26.0" x="1017.0" y="2567.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s849_mpk1_mpk1_sa613"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> </notes> <label text="RAS*"/> <bbox w="50.0" h="25.0" x="1055.125" y="2593.0"/> <glyph class="state variable" id="_a324d211-e878-41fa-899b-7d754adbfa15"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1047.625" y="2600.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1015_mpk1_mpk1_csa19" compartmentRef="mpk1_mpk1_c3_mpk1_mpk1_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ERK*:GRB2:LAMTOR2:MEK*:MP1*:RAF1:RAS*:RTK*:SOS* Identifiers_end</body> </html> </notes> <label text="ERK*:GRB2:LAMTOR2:MEK*:MP1*:RAF1:RAS*:RTK*:SOS*"/> <bbox w="346.0" h="153.0" x="1229.75" y="2532.5"/> <glyph class="macromolecule" id="mpk1_mpk1_s164_mpk1_mpk1_sa103"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 References_end Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 GENECARDS:GRB2 REACTOME:404631 KEGG:2885 ATLASONC:GRB2ID386ch17q25 WIKI:GRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="GRB2"/> <bbox w="50.0" h="25.0" x="1436.25" y="2564.25"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s165_mpk1_mpk1_sa104"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 References_end Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 GENECARDS:SOS1 REACTOME:64848 KEGG:6654 ATLASONC:GC_SOS1 WIKI:SOS1 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 GENECARDS:SOS2 REACTOME:64850 ATLASONC:GC_SOS2 WIKI:SOS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="SOS*"/> <bbox w="50.0" h="25.0" x="1436.25" y="2589.25"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s167_mpk1_mpk1_sa106"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: late endosomal/lysosomal adaptor MODULE:MAPK and MTOR activator 2 "roadblock domain containing 3" ROBLD3 HUGO:LAMTOR2 HGNC:29796 ENTREZ:28956 UNIPROT:Q9Y2Q5 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: P14 is an adaptor protein responsible for the recruitment of MP1 to late endosomes. P14 is peripherally associated with the cytoplasmic face of late endosomes. PMID:17178906 PMID:12479806 References_end</body> </html> </notes> <label text="LAMTOR2"/> <bbox w="65.5" h="29.0" x="1388.5" y="2615.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s168_mpk1_mpk1_sa107"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: late endosomal/lysosomal adaptor MODULE:MAPK and MTOR activator 3 MAP2K1IP1 "MODULE:MAPK scaffold protein 1" MAPKSP1 "mitogen-activated protein kinase kinase 1 interacting protein 1" HUGO:LAMTOR3 HGNC:15606 ENTREZ:8649 UNIPROT:Q9UHA4 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MP1 is localised in late endosomes by P14 forming a very stable heterodimeric complex that is required for ERK activation. It is required for efficient and sustained EGF-induced MEK and ERK activation (in late endosomes) PMID:17178906 References_end</body> </html> </notes> <label text="MP1*"/> <bbox w="66.0" h="26.0" x="1357.0" y="2557.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s170_mpk1_mpk1_sa109"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: v-raf-1 murine leukemia viral oncogene homolog 1 HUGO:RAF1 HGNC:9829 ENTREZ:5894 UNIPROT:P04049 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Active KRas (on late endosomes) recruits Raf1 (C-Raf) to elicit a MODULE:MAPK signalling pathway. Raf1 MEK1/2 and ERK1/2 may act in the outer side of the Golgi apparatus and attenuate proliferation. PMID:19289794 PMID:19565474 References_end Identifiers_begin: v-raf-1 murine leukemia viral oncogene homolog 1 HUGO:RAF1 HGNC:9829 ENTREZ:5894 UNIPROT:P04049 GENECARDS:RAF1 REACTOME:58255 KEGG:5894 ATLASONC:RAF1ID42032ch3p25 WIKI:RAF1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Active KRas (on late endosomes) recruits Raf1 (C-Raf) to elicit a MODULE:MAPK signalling pathway. Raf1 MEK1/2 and ERK1/2 may act in the outer side of the Golgi apparatus and attenuate proliferation. PMID:19289794 PMID:19565474 References_end</body> </html> </notes> <label text="RAF1"/> <bbox w="66.0" h="26.0" x="1305.75" y="2587.5"/> <glyph class="state variable" id="_b865870b-b3a5-4937-8d17-e5f254321b74"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1298.25" y="2595.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s385_mpk1_mpk1_sa258"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1 REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 GENECARDS:MAPK3 KEGG:5595 ATLASONC:MAPK3ID425ch16p11 WIKI:MAPK3 mitogen-activated protein kinase 4 HUGO:MAPK4 HGNC:6878 ENTREZ:5596 UNIPROT:P31152 GENECARDS:MAPK4 KEGG:5596 ATLASONC:MAPK4ID41293ch18q21 WIKI:MAPK4 mitogen-activated protein kinase 6 HUGO:MAPK6 HGNC:6879 ENTREZ:5597 UNIPROT:Q16659 GENECARDS:MAPK6 KEGG:5597 ATLASONC:MAPK6ID43349ch15q21 WIKI:MAPK6 ERK, ERK2, MAPK2, p41mapk Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end</body> </html> </notes> <label text="ERK*"/> <bbox w="66.0" h="26.0" x="1307.1666" y="2639.1665"/> <glyph class="state variable" id="_7ea11688-b7c4-4931-b724-5b8c4b660d12"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1299.6666" y="2651.6975"/> </glyph> <glyph class="state variable" id="_afd92290-7e5c-48f7-ae72-3de8957947fa"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1299.6666" y="2642.0186"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s399_mpk1_mpk1_sa268"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 1 PRKMK1 HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 mitogen-activated protein kinase kinase 2 PRKMK2 HUGO:MAP2K2 HGNC:6842 ENTREZ:5605 UNIPROT:P36507 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: In resting cells MEK1/2 are localised in the cytoplasm and this may be induced by two molecular mechanisms (i.e.: the presence of a nuclear export domain (NES) in their N-terminal domain; the binding to cytoplasmic anchors such as KSR MP1 beta-ARRESTIN-2 Sef1). MEK1 forms a complex with P14 and MP1 on late endosomes necessary for the activation of ERK pathway in this location of the cell. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19565474 PMID:17178906 PMID:15547943 References_end</body> </html> </notes> <label text="MEK*"/> <bbox w="66.0" h="26.0" x="1306.5" y="2613.1665"/> <glyph class="state variable" id="_7bc84657-eec5-4665-8772-307269305532"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1299.0" y="2625.4995"/> </glyph> <glyph class="state variable" id="_dcbd7163-732a-4070-b756-060e1ae70dd5"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1299.0" y="2616.6177"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s819_mpk1_mpk1_sa581"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> </notes> <label text="RTK*"/> <bbox w="50.0" h="25.0" x="1437.8182" y="2541.0908"/> <glyph class="state variable" id="_874a35e0-26f6-46ac-beac-876ba0f6ee1d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1482.8182" y="2553.7686"/> </glyph> <glyph class="state variable" id="_3759715c-d311-4f0c-bb7f-514c500384bb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1482.8182" y="2553.7686"/> </glyph> <glyph class="state variable" id="_9ba52174-529b-44fb-a4d5-670d4b92df51"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1482.8182" y="2548.5908"/> </glyph> <glyph class="unit of information" id="_3c843093-fbfe-4b96-9f9b-b09d8069efa4"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="1440.3182" y="2536.0908"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s852_mpk1_mpk1_sa614"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> </notes> <label text="RAS*"/> <bbox w="50.0" h="25.0" x="1387.875" y="2590.0"/> <glyph class="state variable" id="_6082744e-d388-4b9b-92a6-85bfd18195e2"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1380.375" y="2597.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1016_mpk1_mpk1_csa71" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ERK*:GSK3_beta_*:RSK* Identifiers_end</body> </html> </notes> <label text="ERK*:GSK3β*:RSK*"/> <bbox w="111.0" h="106.0" x="1659.0" y="2631.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s763_mpk1_mpk1_sa352"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1 REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 GENECARDS:MAPK3 KEGG:5595 ATLASONC:MAPK3ID425ch16p11 WIKI:MAPK3 mitogen-activated protein kinase 4 HUGO:MAPK4 HGNC:6878 ENTREZ:5596 UNIPROT:P31152 GENECARDS:MAPK4 KEGG:5596 ATLASONC:MAPK4ID41293ch18q21 WIKI:MAPK4 mitogen-activated protein kinase 6 HUGO:MAPK6 HGNC:6879 ENTREZ:5597 UNIPROT:Q16659 GENECARDS:MAPK6 KEGG:5597 ATLASONC:MAPK6ID43349ch15q21 WIKI:MAPK6 ERK, ERK2, MAPK2, p41mapk Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end</body> </html> </notes> <label text="ERK*"/> <bbox w="50.0" h="25.0" x="1691.0" y="2637.4614"/> <glyph class="state variable" id="_505c64e5-5beb-4289-9591-334ecfa85dcb"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1683.5" y="2649.318"/> </glyph> <glyph class="state variable" id="_e465cdf6-7369-4c19-aa0d-f2b118edd04f"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1683.5" y="2640.0115"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s591_mpk1_mpk1_sa353"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end</body> </html> Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end</body> </html> Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end</body> </html> </notes> <label text="GSK3β*"/> <bbox w="63.0" h="27.0" x="1684.0" y="2663.4614"/> <glyph class="state variable" id="_f27163c0-ae57-44a5-a1d5-78586717c9b5"> <state value="" variable="S9"/> <bbox w="20.0" h="10.0" x="1674.3878" y="2658.4614"/> </glyph> <glyph class="state variable" id="_af273a5c-36c9-412b-a46b-2e827698d172"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1676.5" y="2671.9614"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s592_mpk1_mpk1_sa354"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Modelling choices: - we group here all isoforms of RSK family, as we do not have enough information about the differencies in their behaviour ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ribosomal protein S6 kinase 90kDa polypeptide 1 "ribosomal protein S6 kinase 90kD polypeptide 1" HUGO:RPS6KA1 HGNC:10430 ENTREZ:6195 UNIPROT:Q15418 ribosomal protein S6 kinase 90kDa polypeptide 2 "ribosomal protein S6 kinase 90kD polypeptide 2" HUGO:RPS6KA2 HGNC:10431 ENTREZ:6196 UNIPROT:Q15349 ribosomal protein S6 kinase 90kDa polypeptide 3 CLS "Coffin-Lowry syndrome" "mental retardation X-linked 19" MRX19 "ribosomal protein S6 kinase 90kD polypeptide 3" HUGO:RPS6KA3 HGNC:10432 ENTREZ:6197 UNIPROT:P51812 ribosomal protein S6 kinase 90kDa polypeptide 6 "ribosomal protein S6 kinase 90kD polypeptide 6" HUGO:RPS6KA6 HGNC:10435 ENTREZ:27330 UNIPROT:Q9UK32 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RSK2 is a well known ERK substrate in the cytoplasm. RSKs are exclusively activated by ERK. Activated RSK can be found in both nuclear and cytoplasmic compartments. PMID:15239952 PMID:15187187 References_end Identifiers_begin: ribosomal protein S6 kinase 90kDa polypeptide 1 "ribosomal protein S6 kinase 90kD polypeptide 1" HUGO:RPS6KA1 HGNC:10430 ENTREZ:6195 UNIPROT:Q15418 GENECARDS:RPS6KA1 REACTOME:57795 KEGG:6195 ATLASONC:RPS6KA1ID43477ch1p36 WIKI:RPS6KA1 ribosomal protein S6 kinase 90kDa polypeptide 2 "ribosomal protein S6 kinase 90kD polypeptide 2" HUGO:RPS6KA2 HGNC:10431 ENTREZ:6196 UNIPROT:Q15349 GENECARDS:RPS6KA2 REACTOME:57797 KEGG:6196 ATLASONC:GC_RPS6KA2 WIKI:RPS6KA2 ribosomal protein S6 kinase 90kDa polypeptide 3 CLS "Coffin-Lowry syndrome" "mental retardation X-linked 19" MRX19 "ribosomal protein S6 kinase 90kD polypeptide 3" HUGO:RPS6KA3 HGNC:10432 ENTREZ:6197 UNIPROT:P51812 GENECARDS:RPS6KA3 REACTOME:57799 KEGG:6197 ATLASONC:GC_RPS6KA3 WIKI:RPS6KA3 ribosomal protein S6 kinase 90kDa polypeptide 6 "ribosomal protein S6 kinase 90kD polypeptide 6" HUGO:RPS6KA6 HGNC:10435 ENTREZ:27330 UNIPROT:Q9UK32 GENECARDS:RPS6KA6 REACTOME:57801 KEGG:27330 ATLASONC:GC_RPS6KA6 WIKI:RPS6KA6 ribosomal protein S6 kinase 90kDa polypeptide 4 HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 GENECARDS:RPS6KA4 REACTOME:93591 KEGG:8986 ATLASONC:GC_RPS6KA4 WIKI:RPS6KA4 HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 GENECARDS:RPS6KA4 REACTOME:93591 KEGG:8986 ATLASONC:GC_RPS6KA4 WIKI:RPS6KA4 HUGO:PIM1 HGNC:8986 ENTREZ:5292 UNIPROT:P11309 GENECARDS:PIM1 KEGG:9361 ATLASONC:PIM1ID261 WIKI:PIM1 ribosomal protein S6 kinase, 90kDa, polypeptide 5 HUGO:RPS6KA5 HGNC:10434 ENTREZ:9252 UNIPROT:O75582 GENECARDS:RPS6KA5 REACTOME:93593 KEGG:9252 ATLASONC:GC_RPS6KA5 WIKI:RPS6KA5 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RSK2 is a well known ERK substrate in the cytoplasm. RSKs are exclusively activated by ERK. Activated RSK can be found in both nuclear and cytoplasmic compartments. PMID:15239952 PMID:15187187 PMID:16286006 PMID:21233202 References_end Identifiers_begin: ribosomal protein S6 kinase 90kDa polypeptide 1 "ribosomal protein S6 kinase 90kD polypeptide 1" HUGO:RPS6KA1 HGNC:10430 ENTREZ:6195 UNIPROT:Q15418 GENECARDS:RPS6KA1 REACTOME:57795 KEGG:6195 ATLASONC:RPS6KA1ID43477ch1p36 WIKI:RPS6KA1 ribosomal protein S6 kinase 90kDa polypeptide 2 "ribosomal protein S6 kinase 90kD polypeptide 2" HUGO:RPS6KA2 HGNC:10431 ENTREZ:6196 UNIPROT:Q15349 GENECARDS:RPS6KA2 REACTOME:57797 KEGG:6196 ATLASONC:GC_RPS6KA2 WIKI:RPS6KA2 ribosomal protein S6 kinase 90kDa polypeptide 3 CLS "Coffin-Lowry syndrome" "mental retardation X-linked 19" MRX19 "ribosomal protein S6 kinase 90kD polypeptide 3" HUGO:RPS6KA3 HGNC:10432 ENTREZ:6197 UNIPROT:P51812 GENECARDS:RPS6KA3 REACTOME:57799 KEGG:6197 ATLASONC:GC_RPS6KA3 WIKI:RPS6KA3 ribosomal protein S6 kinase 90kDa polypeptide 6 "ribosomal protein S6 kinase 90kD polypeptide 6" HUGO:RPS6KA6 HGNC:10435 ENTREZ:27330 UNIPROT:Q9UK32 GENECARDS:RPS6KA6 REACTOME:57801 KEGG:27330 ATLASONC:GC_RPS6KA6 WIKI:RPS6KA6 ribosomal protein S6 kinase 90kDa polypeptide 4 HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 GENECARDS:RPS6KA4 REACTOME:93591 KEGG:8986 ATLASONC:GC_RPS6KA4 WIKI:RPS6KA4 HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 GENECARDS:RPS6KA4 REACTOME:93591 KEGG:8986 ATLASONC:GC_RPS6KA4 WIKI:RPS6KA4 HUGO:PIM1 HGNC:8986 ENTREZ:5292 UNIPROT:P11309 GENECARDS:PIM1 KEGG:9361 ATLASONC:PIM1ID261 WIKI:PIM1 ribosomal protein S6 kinase, 90kDa, polypeptide 5 HUGO:RPS6KA5 HGNC:10434 ENTREZ:9252 UNIPROT:O75582 GENECARDS:RPS6KA5 REACTOME:93593 KEGG:9252 ATLASONC:GC_RPS6KA5 WIKI:RPS6KA5 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RSK2 is a well known ERK substrate in the cytoplasm. RSKs are exclusively activated by ERK. Activated RSK can be found in both nuclear and cytoplasmic compartments. PMID:15239952 PMID:15187187 PMID:16286006 PMID:21233202 References_end</body> </html> </notes> <label text="RSK*"/> <bbox w="50.0" h="25.0" x="1689.0" y="2689.4614"/> <glyph class="state variable" id="_4c94aa3a-a6f4-41df-9e97-deb54deff641"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1681.5" y="2696.9614"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1017_mpk1_mpk1_csa49" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DUSP6:ERK* Identifiers_end</body> </html> </notes> <label text="DUSP6:ERK*"/> <bbox w="90.0" h="83.0" x="2093.0" y="2462.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s374_mpk1_mpk1_sa249"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: dual specificity phosphatase 6 HUGO:DUSP6 HGNC:3072 ENTREZ:1848 UNIPROT:Q16828 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: DUSP6 may capture activated ERK2 dephosphorylate it and anchor the inactive kinase in the cytoplasm. PMID:17052211 References_end</body> </html> </notes> <label text="DUSP6"/> <bbox w="50.0" h="25.0" x="2107.5" y="2470.0"/> <glyph class="state variable" id="_f3462dee-695b-4d5d-8025-de32e9d1775f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2102.5" y="2477.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s373_mpk1_mpk1_sa250"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1 REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 GENECARDS:MAPK3 KEGG:5595 ATLASONC:MAPK3ID425ch16p11 WIKI:MAPK3 mitogen-activated protein kinase 4 HUGO:MAPK4 HGNC:6878 ENTREZ:5596 UNIPROT:P31152 GENECARDS:MAPK4 KEGG:5596 ATLASONC:MAPK4ID41293ch18q21 WIKI:MAPK4 mitogen-activated protein kinase 6 HUGO:MAPK6 HGNC:6879 ENTREZ:5597 UNIPROT:Q16659 GENECARDS:MAPK6 KEGG:5597 ATLASONC:MAPK6ID43349ch15q21 WIKI:MAPK6 ERK, ERK2, MAPK2, p41mapk Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end</body> </html> </notes> <label text="ERK*"/> <bbox w="50.0" h="25.0" x="2115.5" y="2496.0"/> <glyph class="state variable" id="_a7432642-ca4a-4776-b66d-d2008e3c68e7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2110.5" y="2507.8567"/> </glyph> <glyph class="state variable" id="_7856273d-2743-4704-a655-2d31999bf830"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2110.5" y="2498.55"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1018_mpk1_mpk1_csa44" compartmentRef="mpk1_mpk1_c9_mpk1_mpk1_ca9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ERK*:GPCR*:GRK*:MEK*:RAF1:_beta_-Arrestin2* Identifiers_end</body> </html> </notes> <label text="ERK*:GPCR*:GRK*:MEK*:RAF1:β-Arrestin2*"/> <bbox w="234.0" h="160.0" x="2468.0" y="2080.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s350_mpk1_mpk1_sa228"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="49.0" h="77.0" x="2600.0" y="2137.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s351_mpk1_mpk1_sa229"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: v-raf-1 murine leukemia viral oncogene homolog 1 HUGO:RAF1 HGNC:9829 ENTREZ:5894 UNIPROT:P04049 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Active KRas (on late endosomes) recruits Raf1 (C-Raf) to elicit a MODULE:MAPK signalling pathway. Raf1 MEK1/2 and ERK1/2 may act in the outer side of the Golgi apparatus and attenuate proliferation. PMID:19289794 PMID:19565474 References_end Identifiers_begin: v-raf-1 murine leukemia viral oncogene homolog 1 HUGO:RAF1 HGNC:9829 ENTREZ:5894 UNIPROT:P04049 GENECARDS:RAF1 REACTOME:58255 KEGG:5894 ATLASONC:RAF1ID42032ch3p25 WIKI:RAF1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Active KRas (on late endosomes) recruits Raf1 (C-Raf) to elicit a MODULE:MAPK signalling pathway. Raf1 MEK1/2 and ERK1/2 may act in the outer side of the Golgi apparatus and attenuate proliferation. PMID:19289794 PMID:19565474 References_end</body> </html> </notes> <label text="RAF1"/> <bbox w="50.0" h="25.0" x="2537.0" y="2139.0"/> <glyph class="state variable" id="_f2ad30b3-1fd1-4905-bdfc-47f03c2f1263"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2529.5" y="2146.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s352_mpk1_mpk1_sa230"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1 REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 GENECARDS:MAPK3 KEGG:5595 ATLASONC:MAPK3ID425ch16p11 WIKI:MAPK3 mitogen-activated protein kinase 4 HUGO:MAPK4 HGNC:6878 ENTREZ:5596 UNIPROT:P31152 GENECARDS:MAPK4 KEGG:5596 ATLASONC:MAPK4ID41293ch18q21 WIKI:MAPK4 mitogen-activated protein kinase 6 HUGO:MAPK6 HGNC:6879 ENTREZ:5597 UNIPROT:Q16659 GENECARDS:MAPK6 KEGG:5597 ATLASONC:MAPK6ID43349ch15q21 WIKI:MAPK6 ERK, ERK2, MAPK2, p41mapk Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end</body> </html> </notes> <label text="ERK*"/> <bbox w="50.0" h="25.0" x="2550.7273" y="2188.5908"/> <glyph class="state variable" id="_dcf2e27a-9238-4e1c-852a-0c44c0562515"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2543.2273" y="2200.4475"/> </glyph> <glyph class="state variable" id="_02400c85-64c9-4d74-bb0a-3fa1a2534691"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2543.2273" y="2191.1409"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s353_mpk1_mpk1_sa231"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 1 PRKMK1 HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 mitogen-activated protein kinase kinase 2 PRKMK2 HUGO:MAP2K2 HGNC:6842 ENTREZ:5605 UNIPROT:P36507 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: In resting cells MEK1/2 are localised in the cytoplasm and this may be induced by two molecular mechanisms (i.e.: the presence of a nuclear export domain (NES) in their N-terminal domain; the binding to cytoplasmic anchors such as KSR MP1 beta-ARRESTIN-2 Sef1). MEK1 forms a complex with P14 and MP1 on late endosomes necessary for the activation of ERK pathway in this location of the cell. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19565474 PMID:17178906 PMID:15547943 References_end</body> </html> </notes> <label text="MEK*"/> <bbox w="50.0" h="25.0" x="2549.0" y="2164.4092"/> <glyph class="state variable" id="_00378b10-eb85-4479-96ff-bbbdc8320d55"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2541.5" y="2176.0754"/> </glyph> <glyph class="state variable" id="_0f22942c-a9f5-491b-bf62-7eee03a76b36"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2541.5" y="2167.5352"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s540_mpk1_mpk1_sa314"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adrenergic beta receptor kinase 1 HUGO:ADRBK1 HGNC:289 ENTREZ:156 UNIPROT:P25098 adrenergic beta receptor kinase 2 HUGO:ADRBK2 HGNC:290 ENTREZ:157 UNIPROT:P35626 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN. PMID:11226259 References_end Identifiers_begin: G protein-coupled receptor kinase 1 HUGO:GRK1 HGNC:10013 ENTREZ:6011 UNIPROT:Q15835 GENECARDS:GRK1 KEGG:6011 ATLASONC:GC_GRK1 WIKI:GRK1 G protein-coupled receptor kinase 4 HUGO:GRK4 HGNC:4543 ENTREZ:2868 UNIPROT:P32298 GENECARDS:GRK4 KEGG:2868 ATLASONC:GC_GRK4 WIKI:GRK4 G protein-coupled receptor kinase 5 HUGO:GRK5 HGNC:4544 ENTREZ:2869 UNIPROT:P34947 GENECARDS:GRK5 REACTOME:55956 KEGG:2869 WIKI:GRK5 G protein-coupled receptor kinase 6 HUGO:GRK6 HGNC:4545 ENTREZ:2870 UNIPROT:P43250 GENECARDS:GRK6 KEGG:2870 ATLASONC:GC_GRK6 WIKI:GRK6 G protein-coupled receptor kinase 7 HUGO:GRK7 HGNC:17031 ENTREZ:131890 UNIPROT:Q8WTQ7 GENECARDS:GRK7 KEGG:131890 WIKI:GRK7 adrenergic beta receptor kinase 1 HUGO:ADRBK1 HGNC:289 ENTREZ:156 UNIPROT:P25098 GENECARDS:ADRBK1 REACTOME:50271 KEGG:156 ATLASONC:GC_ADRBK1 WIKI:ADRBK1 adrenergic beta receptor kinase 2 HUGO:ADRBK2 HGNC:290 ENTREZ:157 UNIPROT:P35626 GENECARDS:ADRBK2 KEGG:157 ATLASONC:GC_ADRBK2 WIKI:ADRBK2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK Maps_Modules_end References_begin: PMID:16525728 PMID:15618519 Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN. PMID:11226259 References_end</body> </html> </notes> <label text="GRK*"/> <bbox w="50.0" h="25.0" x="2599.5" y="2111.3333"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s816_mpk1_mpk1_sa578"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: G protein-coupled receptor 1 HUGO:GPR1 HGNC:4463 ENTREZ:2825 UNIPROT:P46091 G protein-coupled receptor 3 HUGO:GPR3 HGNC:4484 ENTREZ:2827 UNIPROT:P46089 G protein-coupled receptor 4 HUGO:GPR4 HGNC:4497 ENTREZ:2828 UNIPROT:P46093 G protein-coupled receptor 6 HUGO:GPR6 HGNC:4515 ENTREZ:2830 UNIPROT:P46095 G protein-coupled receptor 12 HUGO:GPR12 HGNC:4466 ENTREZ:2835 UNIPROT:P47775 G protein-coupled receptor 15 HUGO:GPR15 HGNC:4469 ENTREZ:2838 UNIPROT:P49685 G protein-coupled receptor 17 HUGO:GPR17 HGNC:4471 ENTREZ:2840 UNIPROT:Q13304 G protein-coupled receptor 18 HUGO:GPR18 HGNC:4472 ENTREZ:2841 UNIPROT:Q14330 G protein-coupled receptor 19 HUGO:GPR19 HGNC:4473 ENTREZ:2842 UNIPROT:Q15760 G protein-coupled receptor 20 HUGO:GPR20 HGNC:4475 ENTREZ:2843 UNIPROT:Q99678 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Phosphorylation of GPCR (by GRK) induces the activation of ERK cascade on eary endosomes. PMID:19565474 References_end</body> </html> </notes> <label text="GPCR*"/> <bbox w="50.0" h="25.0" x="2601.5454" y="2088.9092"/> <glyph class="state variable" id="_3c359c73-8bb0-40b0-af54-e5efe1b51c36"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2596.5454" y="2096.4092"/> </glyph> <glyph class="unit of information" id="_075ce3f9-4e3a-49b8-adc0-4809e54d636b"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2604.0454" y="2083.9092"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1019_mpk1_mpk1_csa70" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:LEF_TCF*:_beta_-Catenin* Identifiers_end</body> </html> </notes> <label text="LEF_TCF*:β-Catenin*"/> <bbox w="120.0" h="83.0" x="327.0" y="3024.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s765_mpk1_mpk1_sa350"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="72.0" h="26.0" x="351.6154" y="3035.2307"/> <glyph class="state variable" id="_d7137bf5-7489-408d-8b56-e48a1cfb793a"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="375.0294" y="3056.2307"/> </glyph> <glyph class="state variable" id="_a90e2c73-7a41-416d-b3a5-75ac9ed1fddc"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="410.559" y="3056.2307"/> </glyph> <glyph class="state variable" id="_96fb8abe-9b06-4850-b000-c9faad4b8af5"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="411.1154" y="3030.3704"/> </glyph> <glyph class="state variable" id="_0e419f8f-344b-420e-8abc-c99f6b1614a1"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="375.14404" y="3030.2307"/> </glyph> <glyph class="state variable" id="_7e1d3e9c-457f-43e1-b0b7-29aaaa636b26"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="339.55865" y="3030.2307"/> </glyph> <glyph class="state variable" id="_85ce044f-b029-4119-b287-f074bca53d67"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="339.1154" y="3056.0503"/> </glyph> <glyph class="state variable" id="_1e0a5f30-ce05-4d78-87a2-abab3119686f"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="408.6154" y="3030.3704"/> </glyph> <glyph class="state variable" id="_aecb6839-ec1b-41db-9e60-cc76ab4b3d0e"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="408.6154" y="3030.3704"/> </glyph> <glyph class="state variable" id="_a7687334-a049-4bc3-af3a-5fe0354d6977"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="346.6154" y="3043.2307"/> </glyph> <glyph class="state variable" id="_3a577fc6-10f2-46b3-8f9e-9e53c2809076"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="337.05865" y="3030.2307"/> </glyph> <glyph class="state variable" id="_652e5b54-48b7-4fe8-93f1-bd5cb972c09c"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="408.6154" y="3030.3704"/> </glyph> <glyph class="state variable" id="_ec69efeb-3d4e-4162-b74d-c43684484fa6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="346.6154" y="3037.846"/> </glyph> <glyph class="state variable" id="_4871881f-8424-46ac-9aa1-3ddb1ab73fa9"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="408.6154" y="3030.3704"/> </glyph> <glyph class="state variable" id="_d410f72f-2a73-43a4-874c-e1375b557df9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="346.6154" y="3043.2307"/> </glyph> <glyph class="state variable" id="_a68ca309-8e5d-4724-b1a6-cd92ea5a4725"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="408.059" y="3056.2307"/> </glyph> <glyph class="state variable" id="_c07cbd85-5352-44fb-9655-d6954d1ed2aa"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="408.6154" y="3030.3704"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s766_mpk1_mpk1_sa351"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 transcription factor 7-like 1 (T-cell specific HMG-box) TCF3 HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 transcription factor 7-like 2 (T-cell specific HMG-box) TCF4 HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end</body> </html> Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end</body> </html> </notes> <label text="LEF_TCF*"/> <bbox w="65.0" h="25.0" x="353.6154" y="3060.2307"/> <glyph class="state variable" id="_abecbc7d-dd98-44a4-8b71-6de5b2fc249c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="413.6154" y="3055.7795"/> </glyph> <glyph class="state variable" id="_6d139007-3f22-4b6f-a3d9-e498eecca29d"> <state value="" variable="S40"/> <bbox w="25.0" h="10.0" x="406.1154" y="3078.1145"/> </glyph> <glyph class="state variable" id="_c9936902-1249-4e37-9b0f-2dfcc1f208e4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="413.6154" y="3067.7307"/> </glyph> <glyph class="state variable" id="_53c7ad06-2194-40ed-ad4d-d636ab48f615"> <state value="" variable="S166"/> <bbox w="30.0" h="10.0" x="339.01556" y="3055.2307"/> </glyph> <glyph class="state variable" id="_28b2d11b-eaab-4508-b459-ca3adbf426a2"> <state value="" variable="T155"/> <bbox w="30.0" h="10.0" x="338.6154" y="3080.0571"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1020_mpk1_mpk1_csa48" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DUSP5:ERK* Identifiers_end</body> </html> </notes> <label text="DUSP5:ERK*"/> <bbox w="85.0" h="90.0" x="707.0" y="3061.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s366_mpk1_mpk1_sa244"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: dual specificity phosphatase 5 HUGO:DUSP5 HGNC:3071 ENTREZ:1847 UNIPROT:Q16690 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: DUSP5 represents an inducible ERK-specific MKP and it functions as both a nuclear anchor and inactivator of ERK MODULE:MAPK in mammalian cells. PMID:17052211 References_end</body> </html> </notes> <label text="DUSP5"/> <bbox w="60.0" h="27.0" x="721.0" y="3074.0"/> <glyph class="state variable" id="_2b29b4c2-1683-4660-8036-f686202bc15c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="716.0" y="3082.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s370_mpk1_mpk1_sa247"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1 REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 GENECARDS:MAPK3 KEGG:5595 ATLASONC:MAPK3ID425ch16p11 WIKI:MAPK3 mitogen-activated protein kinase 4 HUGO:MAPK4 HGNC:6878 ENTREZ:5596 UNIPROT:P31152 GENECARDS:MAPK4 KEGG:5596 ATLASONC:MAPK4ID41293ch18q21 WIKI:MAPK4 mitogen-activated protein kinase 6 HUGO:MAPK6 HGNC:6879 ENTREZ:5597 UNIPROT:Q16659 GENECARDS:MAPK6 KEGG:5597 ATLASONC:MAPK6ID43349ch15q21 WIKI:MAPK6 ERK, ERK2, MAPK2, p41mapk Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end</body> </html> </notes> <label text="ERK*"/> <bbox w="60.0" h="27.0" x="726.5" y="3101.0"/> <glyph class="state variable" id="_d9b768e8-c030-457f-a8f3-918c2c78932e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="721.5" y="3114.205"/> </glyph> <glyph class="state variable" id="_42dcdbfb-a134-4877-a7cd-c908241882dc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="721.5" y="3104.154"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1024_mpk1_mpk1_csa106" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DUSP1:JNK* Identifiers_end</body> </html> </notes> <label text="DUSP1:JNK*"/> <bbox w="105.0" h="86.0" x="2322.0" y="3025.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s792_mpk1_mpk1_sa547"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: dual specificity phosphatase 1 PTPN10 HUGO:DUSP1 HGNC:3064 ENTREZ:1843 UNIPROT:P28562 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MKP-1 (DUSP1) preferentially inactivates JNK and P38. DUSP1 play its phosphatase role in the nucleus. PMID:19436832 PMID:17496916 References_end</body> </html> </notes> <label text="DUSP1"/> <bbox w="62.0" h="25.0" x="2344.2856" y="3033.8572"/> <glyph class="state variable" id="_250aacef-0ee8-4423-b639-92c8358ff9ac"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2339.2856" y="3041.3572"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s794_mpk1_mpk1_sa549"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: mitogen-activated protein kinase 8 PRKM8 HUGO:MAPK8 HGNC:6881 ENTREZ:5599 UNIPROT:P45983 mitogen-activated protein kinase 9 PRKM9 HUGO:MAPK9 HGNC:6886 ENTREZ:5601 UNIPROT:P45984 mitogen-activated protein kinase 10 PRKM10 HUGO:MAPK10 HGNC:6872 ENTREZ:5602 UNIPROT:P53779 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: mitogen-activated protein kinase 8 PRKM8 HUGO:MAPK8 HGNC:6881 ENTREZ:5599 UNIPROT:P45983 GENECARDS:MAPK8 REACTOME:59293 KEGG:5599 ATLASONC:JNK1ID196 WIKI:MAPK8 mitogen-activated protein kinase 9 PRKM9 HUGO:MAPK9 HGNC:6886 ENTREZ:5601 UNIPROT:P45984 GENECARDS:MAPK9 REACTOME:59295 KEGG:5601 ATLASONC:JNK2ID426 WIKI:MAPK9 mitogen-activated protein kinase 10 PRKM10 HUGO:MAPK10 HGNC:6872 ENTREZ:5602 UNIPROT:P53779 GENECARDS:MAPK10 REACTOME:59297 KEGG:5602 ATLASONC:JNK3ID427 WIKI:MAPK10 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="JNK*"/> <bbox w="62.0" h="25.0" x="2352.0" y="3059.8572"/> <glyph class="state variable" id="_4d8eba59-e5e9-40ad-b177-7da7e0b8b91f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2347.0" y="3072.1096"/> </glyph> <glyph class="state variable" id="_9d21b5ed-abba-48c4-998a-d9acc0d37d67"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2347.0" y="3062.6047"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1025_mpk1_mpk1_csa107" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DUSP1:p38* Identifiers_end</body> </html> </notes> <label text="DUSP1:p38*"/> <bbox w="91.0" h="86.0" x="2865.0" y="3051.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s791_mpk1_mpk1_sa546"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: dual specificity phosphatase 1 PTPN10 HUGO:DUSP1 HGNC:3064 ENTREZ:1843 UNIPROT:P28562 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MKP-1 (DUSP1) preferentially inactivates JNK and P38. DUSP1 play its phosphatase role in the nucleus. PMID:19436832 PMID:17496916 References_end</body> </html> </notes> <label text="DUSP1"/> <bbox w="62.0" h="25.0" x="2880.2856" y="3058.8572"/> <glyph class="state variable" id="_f4d7d3a2-93b8-421a-9186-90e0d39282ca"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2875.2856" y="3066.3572"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s793_mpk1_mpk1_sa548"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: mitogen-activated protein kinase 11 PRKM11 HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 mitogen-activated protein kinase 12 SAPK3 HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 mitogen-activated protein kinase 13 PRKM13 HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 mitogen-activated protein kinase 14 CSBP1 CSBP2 CSPB1 HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: mitogen-activated protein kinase 11 PRKM11 HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 GENECARDS:MAPK11 REACTOME:59299 KEGG:5600 ATLASONC:GC_MAPK11 WIKI:MAPK11 mitogen-activated protein kinase 12 SAPK3 HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 GENECARDS:MAPK12 REACTOME:69723 KEGG:6300 ATLASONC:MAPK12ID41290ch22q13 WIKI:MAPK12 mitogen-activated protein kinase 13 PRKM13 HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 GENECARDS:MAPK13 REACTOME:59303 KEGG:5603 ATLASONC:MAPK13ID41291ch6p21 WIKI:MAPK13 mitogen-activated protein kinase 14 CSBP1 CSBP2 CSPB1 HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 GENECARDS:MAPK14 REACTOME:405912 KEGG:1432 ATLASONC:MAPK14ID41292ch6p21 WIKI:MAPK14 Mxi2 P38 "P38 MAP kinase" PRKM14 PRKM15 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> Identifiers_begin: mitogen-activated protein kinase 11 PRKM11 HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 GENECARDS:MAPK11 REACTOME:59299 KEGG:5600 ATLASONC:GC_MAPK11 WIKI:MAPK11 mitogen-activated protein kinase 12 SAPK3 HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 GENECARDS:MAPK12 REACTOME:69723 KEGG:6300 ATLASONC:MAPK12ID41290ch22q13 WIKI:MAPK12 mitogen-activated protein kinase 13 PRKM13 HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 GENECARDS:MAPK13 REACTOME:59303 KEGG:5603 ATLASONC:MAPK13ID41291ch6p21 WIKI:MAPK13 mitogen-activated protein kinase 14 CSBP1 CSBP2 CSPB1 HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 GENECARDS:MAPK14 REACTOME:405912 KEGG:1432 ATLASONC:MAPK14ID41292ch6p21 WIKI:MAPK14 Mxi2 P38 "P38 MAP kinase" PRKM14 PRKM15 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="p38*"/> <bbox w="62.0" h="25.0" x="2889.2856" y="3083.8572"/> <glyph class="state variable" id="_c89e8b6a-2a5a-4f68-bf0f-5fc449db1463"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2884.2856" y="3095.989"/> </glyph> <glyph class="state variable" id="_58cb1285-fed1-40c7-9151-5392fb7ea6a8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2884.2856" y="3086.7832"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1027_mpk1_mpk1_csa109" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:SMAD3:SMAD4 Identifiers_end</body> </html> </notes> <label text="SMAD3:SMAD4"/> <bbox w="100.0" h="80.0" x="3730.0" y="2950.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s920_mpk1_mpk1_sa673"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: SMAD family member 3 "MAD mothers against decapentaplegic homolog 3 (Drosophila)" MADH3 "SMAD mothers against DPP homolog 3 (Drosophila)" HUGO:SMAD3 HGNC:6769 ENTREZ:4088 UNIPROT:P84022 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TGF-?? exerts its biological effects by binding to a cell surface receptor complex composed of type I (TbRI) and type II (TbRII) receptor serine/threonine kinases. Upon ligand binding TbRII phosphorylates and activates TbRI which subsequently phosphorylates the cytoplasmic Smad2 and Smad3 proteins. Phosphorylated Smad proteins form stable complexes with a common partner Smad4. The activated Smad2/4 and Smad3/4 complexes translocate into the nucleus where the Smad oligomers induce transcriptional activation (or inhibition) of specific target genes. PMID:21614932 References_end</body> </html> </notes> <label text="SMAD3"/> <bbox w="50.0" h="25.0" x="3755.0" y="2957.5"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s915_mpk1_mpk1_sa676"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: SMAD family member 4 "MAD mothers against decapentaplegic homolog 4 (Drosophila)" MADH4 "SMAD mothers against DPP homolog 4 (Drosophila)" HUGO:SMAD4 HGNC:6770 ENTREZ:4089 UNIPROT:Q13485 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TGF-?? exerts its biological effects by binding to a cell surface receptor complex composed of type I (TbRI) and type II (TbRII) receptor serine/threonine kinases. Upon ligand binding TbRII phosphorylates and activates TbRI which subsequently phosphorylates the cytoplasmic Smad2 and Smad3 proteins. Phosphorylated Smad proteins form stable complexes with a common partner Smad4. The activated Smad2/4 and Smad3/4 complexes translocate into the nucleus where the Smad oligomers induce transcriptional activation (or inhibition) of specific target genes. PMID:21614932 References_end</body> </html> </notes> <label text="SMAD4"/> <bbox w="50.0" h="25.0" x="3755.0" y="2981.5"/> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1028_mpk1_mpk1_csa108" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:SMAD2:SMAD4 Identifiers_end</body> </html> </notes> <label text="SMAD2:SMAD4"/> <bbox w="100.0" h="80.0" x="3610.0" y="2950.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s919_mpk1_mpk1_sa674"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: SMAD family member 2 "MAD mothers against decapentaplegic homolog 2 (Drosophila)" MADH2 "SMAD mothers against DPP homolog 2 (Drosophila)" HUGO:SMAD2 HGNC:6768 ENTREZ:4087 UNIPROT:Q15796 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TGF-?? exerts its biological effects by binding to a cell surface receptor complex composed of type I (TbRI) and type II (TbRII) receptor serine/threonine kinases. Upon ligand binding TbRII phosphorylates and activates TbRI which subsequently phosphorylates the cytoplasmic Smad2 and Smad3 proteins. Phosphorylated Smad proteins form stable complexes with a common partner Smad4. The activated Smad2/4 and Smad3/4 complexes translocate into the nucleus where the Smad oligomers induce transcriptional activation (or inhibition) of specific target genes. PMID:21614932 References_end Identifiers_begin: SMAD family member 2 "MAD mothers against decapentaplegic homolog 2 (Drosophila)" MADH2 "SMAD mothers against DPP homolog 2 (Drosophila)" HUGO:SMAD2 HGNC:6768 ENTREZ:4087 UNIPROT:Q15796 GENECARDS:SMAD2 REACTOME:405890 KEGG:4087 ATLASONC:SMAD2ID370 WIKI:SMAD2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: TGF-?? exerts its biological effects by binding to a cell surface receptor complex composed of type I (TbRI) and type II (TbRII) receptor serine/threonine kinases. Upon ligand binding TbRII phosphorylates and activates TbRI which subsequently phosphorylates the cytoplasmic Smad2 and Smad3 proteins. Phosphorylated Smad proteins form stable complexes with a common partner Smad4. The activated Smad2/4 and Smad3/4 complexes translocate into the nucleus where the Smad oligomers induce transcriptional activation (or inhibition) of specific target genes. PMID:21614932 References_end</body> </html> </notes> <label text="SMAD2"/> <bbox w="50.0" h="25.0" x="3635.0" y="2954.5"/> <glyph class="state variable" id="_eb766e1b-2121-4568-b415-63b5ff849596"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3680.0" y="2949.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s918_mpk1_mpk1_sa675"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: SMAD family member 4 "MAD mothers against decapentaplegic homolog 4 (Drosophila)" MADH4 "SMAD mothers against DPP homolog 4 (Drosophila)" HUGO:SMAD4 HGNC:6770 ENTREZ:4089 UNIPROT:Q13485 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TGF-?? exerts its biological effects by binding to a cell surface receptor complex composed of type I (TbRI) and type II (TbRII) receptor serine/threonine kinases. Upon ligand binding TbRII phosphorylates and activates TbRI which subsequently phosphorylates the cytoplasmic Smad2 and Smad3 proteins. Phosphorylated Smad proteins form stable complexes with a common partner Smad4. The activated Smad2/4 and Smad3/4 complexes translocate into the nucleus where the Smad oligomers induce transcriptional activation (or inhibition) of specific target genes. PMID:21614932 References_end</body> </html> </notes> <label text="SMAD4"/> <bbox w="50.0" h="25.0" x="3635.0" y="2979.5"/> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1029_mpk1_mpk1_csa65" compartmentRef="mpk1_mpk1_c9_mpk1_mpk1_ca9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GPCR*:GRK* Identifiers_end</body> </html> </notes> <label text="GPCR*:GRK*"/> <bbox w="84.0" h="82.0" x="2114.0" y="2103.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s548_mpk1_mpk1_sa318"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adrenergic beta receptor kinase 1 HUGO:ADRBK1 HGNC:289 ENTREZ:156 UNIPROT:P25098 adrenergic beta receptor kinase 2 HUGO:ADRBK2 HGNC:290 ENTREZ:157 UNIPROT:P35626 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN. PMID:11226259 References_end Identifiers_begin: G protein-coupled receptor kinase 1 HUGO:GRK1 HGNC:10013 ENTREZ:6011 UNIPROT:Q15835 GENECARDS:GRK1 KEGG:6011 ATLASONC:GC_GRK1 WIKI:GRK1 G protein-coupled receptor kinase 4 HUGO:GRK4 HGNC:4543 ENTREZ:2868 UNIPROT:P32298 GENECARDS:GRK4 KEGG:2868 ATLASONC:GC_GRK4 WIKI:GRK4 G protein-coupled receptor kinase 5 HUGO:GRK5 HGNC:4544 ENTREZ:2869 UNIPROT:P34947 GENECARDS:GRK5 REACTOME:55956 KEGG:2869 WIKI:GRK5 G protein-coupled receptor kinase 6 HUGO:GRK6 HGNC:4545 ENTREZ:2870 UNIPROT:P43250 GENECARDS:GRK6 KEGG:2870 ATLASONC:GC_GRK6 WIKI:GRK6 G protein-coupled receptor kinase 7 HUGO:GRK7 HGNC:17031 ENTREZ:131890 UNIPROT:Q8WTQ7 GENECARDS:GRK7 KEGG:131890 WIKI:GRK7 adrenergic beta receptor kinase 1 HUGO:ADRBK1 HGNC:289 ENTREZ:156 UNIPROT:P25098 GENECARDS:ADRBK1 REACTOME:50271 KEGG:156 ATLASONC:GC_ADRBK1 WIKI:ADRBK1 adrenergic beta receptor kinase 2 HUGO:ADRBK2 HGNC:290 ENTREZ:157 UNIPROT:P35626 GENECARDS:ADRBK2 KEGG:157 ATLASONC:GC_ADRBK2 WIKI:ADRBK2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK Maps_Modules_end References_begin: PMID:16525728 PMID:15618519 Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN. PMID:11226259 References_end</body> </html> </notes> <label text="GRK*"/> <bbox w="50.0" h="25.0" x="2131.8333" y="2135.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s815_mpk1_mpk1_sa577"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: G protein-coupled receptor 1 HUGO:GPR1 HGNC:4463 ENTREZ:2825 UNIPROT:P46091 G protein-coupled receptor 3 HUGO:GPR3 HGNC:4484 ENTREZ:2827 UNIPROT:P46089 G protein-coupled receptor 4 HUGO:GPR4 HGNC:4497 ENTREZ:2828 UNIPROT:P46093 G protein-coupled receptor 6 HUGO:GPR6 HGNC:4515 ENTREZ:2830 UNIPROT:P46095 G protein-coupled receptor 12 HUGO:GPR12 HGNC:4466 ENTREZ:2835 UNIPROT:P47775 G protein-coupled receptor 15 HUGO:GPR15 HGNC:4469 ENTREZ:2838 UNIPROT:P49685 G protein-coupled receptor 17 HUGO:GPR17 HGNC:4471 ENTREZ:2840 UNIPROT:Q13304 G protein-coupled receptor 18 HUGO:GPR18 HGNC:4472 ENTREZ:2841 UNIPROT:Q14330 G protein-coupled receptor 19 HUGO:GPR19 HGNC:4473 ENTREZ:2842 UNIPROT:Q15760 G protein-coupled receptor 20 HUGO:GPR20 HGNC:4475 ENTREZ:2843 UNIPROT:Q99678 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Phosphorylation of GPCR (by GRK) induces the activation of ERK cascade on eary endosomes. PMID:19565474 References_end</body> </html> </notes> <label text="GPCR*"/> <bbox w="50.0" h="25.0" x="2132.818" y="2111.9092"/> <glyph class="state variable" id="_88c15f53-0bbb-4995-b874-7f7f711cd38a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2127.818" y="2119.4092"/> </glyph> <glyph class="unit of information" id="_5a5154dc-2e87-4a56-a0dc-e07a38b317dd"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2135.318" y="2106.9092"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1030_mpk1_mpk1_csa27" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:KSR1:MEK* Identifiers_end</body> </html> </notes> <label text="KSR1:MEK*"/> <bbox w="112.0" h="108.0" x="1687.0" y="1838.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s237_mpk1_mpk1_sa148"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: kinase suppressor of ras 1 "kinase suppressor of ras" KSR HUGO:KSR1 HGNC:6465 ENTREZ:8844 UNIPROT:Q8IVT5 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: KSR1 is a scaffold protein for ERK cascade. It normally localises in the cytosol but after GF treatment it moves to the plasma membrane. Its interaction with MEK1/2 is constitutive. Under endogenous conditions KSR1 facilitates the association of MEK and B-Raf (and not C-Raf) thus promoting MEK and ERK activation (on plasma membrane). PMID:19541618 References_end</body> </html> </notes> <label text="KSR1"/> <bbox w="41.0" h="77.0" x="1697.0" y="1849.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s238_mpk1_mpk1_sa149"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 1 PRKMK1 HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 mitogen-activated protein kinase kinase 2 PRKMK2 HUGO:MAP2K2 HGNC:6842 ENTREZ:5605 UNIPROT:P36507 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: In resting cells MEK1/2 are localised in the cytoplasm and this may be induced by two molecular mechanisms (i.e.: the presence of a nuclear export domain (NES) in their N-terminal domain; the binding to cytoplasmic anchors such as KSR MP1 beta-ARRESTIN-2 Sef1). MEK1 forms a complex with P14 and MP1 on late endosomes necessary for the activation of ERK pathway in this location of the cell. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19565474 PMID:17178906 PMID:15547943 References_end</body> </html> </notes> <label text="MEK*"/> <bbox w="50.0" h="25.0" x="1740.5" y="1874.5"/> <glyph class="state variable" id="_6e012b78-acf2-47c0-8870-9d567a1b5949"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1735.5" y="1886.1664"/> </glyph> <glyph class="state variable" id="_d5f6a6f3-8637-4bee-b614-7a9e1e9fbd51"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1735.5" y="1877.6261"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1031_mpk1_mpk1_csa26" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:KSR1-CTER*:MEK* Identifiers_end</body> </html> </notes> <label text="KSR1-CTER*:MEK*"/> <bbox w="134.0" h="85.0" x="2016.0" y="1871.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s213_mpk1_mpk1_sa131"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: kinase suppressor of ras 1 "kinase suppressor of ras" KSR HUGO:KSR1 HGNC:6465 ENTREZ:8844 UNIPROT:Q8IVT5 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: KSR1 is cleaved by CASPASE3 in two regions: the C-ter region which mediates MEK binding and the N-ter region which contains the ERK binding site and the C1 domain required for plasma membrane localisation PMID:17613518 References_end</body> </html> </notes> <label text="KSR1-CTER*"/> <bbox w="119.0" h="26.0" x="2023.0" y="1880.0"/> <glyph class="unit of information" id="_98ea1947-d558-4009-a7a7-73ede59633bb"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="2057.5" y="1875.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s214_mpk1_mpk1_sa132"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 1 PRKMK1 HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 mitogen-activated protein kinase kinase 2 PRKMK2 HUGO:MAP2K2 HGNC:6842 ENTREZ:5605 UNIPROT:P36507 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: In resting cells MEK1/2 are localised in the cytoplasm and this may be induced by two molecular mechanisms (i.e.: the presence of a nuclear export domain (NES) in their N-terminal domain; the binding to cytoplasmic anchors such as KSR MP1 beta-ARRESTIN-2 Sef1). MEK1 forms a complex with P14 and MP1 on late endosomes necessary for the activation of ERK pathway in this location of the cell. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19565474 PMID:17178906 PMID:15547943 References_end</body> </html> </notes> <label text="MEK*"/> <bbox w="66.0" h="26.0" x="2055.5" y="1906.5"/> <glyph class="state variable" id="_c0135b82-8987-499a-a288-706963ae5b44"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2050.5" y="1918.833"/> </glyph> <glyph class="state variable" id="_aed36447-d6ad-42ca-a9b7-12a5d6685ea6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2050.5" y="1909.951"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1032_mpk1_mpk1_csa10" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:IMP*:KSR1:MEK* Identifiers_end</body> </html> </notes> <label text="IMP*:KSR1:MEK*"/> <bbox w="163.0" h="109.0" x="2246.5" y="1896.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s80_mpk1_mpk1_sa60"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: kinase suppressor of ras 1 "kinase suppressor of ras" KSR HUGO:KSR1 HGNC:6465 ENTREZ:8844 UNIPROT:Q8IVT5 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: KSR1 is a scaffold protein for ERK cascade. It normally localises in the cytosol but after GF treatment it moves to the plasma membrane. Its interaction with MEK1/2 is constitutive. Under endogenous conditions KSR1 facilitates the association of MEK and B-Raf (and not C-Raf) thus promoting MEK and ERK activation (on plasma membrane). PMID:19541618 References_end</body> </html> </notes> <label text="KSR1"/> <bbox w="49.0" h="76.0" x="2304.5" y="1906.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s81_mpk1_mpk1_sa61"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 1 PRKMK1 HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 mitogen-activated protein kinase kinase 2 PRKMK2 HUGO:MAP2K2 HGNC:6842 ENTREZ:5605 UNIPROT:P36507 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: In resting cells MEK1/2 are localised in the cytoplasm and this may be induced by two molecular mechanisms (i.e.: the presence of a nuclear export domain (NES) in their N-terminal domain; the binding to cytoplasmic anchors such as KSR MP1 beta-ARRESTIN-2 Sef1). MEK1 forms a complex with P14 and MP1 on late endosomes necessary for the activation of ERK pathway in this location of the cell. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19565474 PMID:17178906 PMID:15547943 References_end</body> </html> </notes> <label text="MEK*"/> <bbox w="50.0" h="25.0" x="2349.5" y="1932.0"/> <glyph class="state variable" id="_e411be08-fede-4a6e-bc42-a1c22c8145dc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2344.5" y="1943.6664"/> </glyph> <glyph class="state variable" id="_fe0d2cf4-6b7b-4034-b957-b5d253fe55c5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2344.5" y="1935.1261"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s234_mpk1_mpk1_sa146"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: BRCA1 associated protein HUGO:BRAP HGNC:1099 ENTREZ:8315 UNIPROT:Q7Z569 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: IMP (BRAP) is a RasGTP-interacting protein. It is constitutively bound to KSR1 blocking the enhancement of ERK activation (KSR1 is kept in an inactivated state) maybe recruiting KSR1 to microdomains inaccessible to activators of its function. This could be a mechanism to limit the engagement of ERK cascade in the absence of Ras activation. PMID:14724641 References_end</body> </html> </notes> <label text="IMP*"/> <bbox w="50.0" h="25.0" x="2254.5" y="1931.5"/> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1033_mpk1_mpk1_csa61" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ERK*:KSR1:MEK* Identifiers_end</body> </html> </notes> <label text="ERK*:KSR1:MEK*"/> <bbox w="136.0" h="110.0" x="1623.0" y="2034.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s519_mpk1_mpk1_sa298"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: kinase suppressor of ras 1 "kinase suppressor of ras" KSR HUGO:KSR1 HGNC:6465 ENTREZ:8844 UNIPROT:Q8IVT5 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: KSR1 is a scaffold protein for ERK cascade. It normally localises in the cytosol but after GF treatment it moves to the plasma membrane. Its interaction with MEK1/2 is constitutive. Under endogenous conditions KSR1 facilitates the association of MEK and B-Raf (and not C-Raf) thus promoting MEK and ERK activation (on plasma membrane). PMID:19541618 References_end</body> </html> </notes> <label text="KSR1"/> <bbox w="50.0" h="25.0" x="1637.3334" y="2042.6667"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s520_mpk1_mpk1_sa299"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 1 PRKMK1 HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 mitogen-activated protein kinase kinase 2 PRKMK2 HUGO:MAP2K2 HGNC:6842 ENTREZ:5605 UNIPROT:P36507 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: In resting cells MEK1/2 are localised in the cytoplasm and this may be induced by two molecular mechanisms (i.e.: the presence of a nuclear export domain (NES) in their N-terminal domain; the binding to cytoplasmic anchors such as KSR MP1 beta-ARRESTIN-2 Sef1). MEK1 forms a complex with P14 and MP1 on late endosomes necessary for the activation of ERK pathway in this location of the cell. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19565474 PMID:17178906 PMID:15547943 References_end</body> </html> </notes> <label text="MEK*"/> <bbox w="50.0" h="25.0" x="1683.3334" y="2069.6667"/> <glyph class="state variable" id="_16aaf359-a600-44c1-8097-343716ec1aec"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1675.8334" y="2081.333"/> </glyph> <glyph class="state variable" id="_78fa69b0-9958-43fa-81a9-338da27e9f69"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1675.8334" y="2072.7927"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s521_mpk1_mpk1_sa300"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1 REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 GENECARDS:MAPK3 KEGG:5595 ATLASONC:MAPK3ID425ch16p11 WIKI:MAPK3 mitogen-activated protein kinase 4 HUGO:MAPK4 HGNC:6878 ENTREZ:5596 UNIPROT:P31152 GENECARDS:MAPK4 KEGG:5596 ATLASONC:MAPK4ID41293ch18q21 WIKI:MAPK4 mitogen-activated protein kinase 6 HUGO:MAPK6 HGNC:6879 ENTREZ:5597 UNIPROT:Q16659 GENECARDS:MAPK6 KEGG:5597 ATLASONC:MAPK6ID43349ch15q21 WIKI:MAPK6 ERK, ERK2, MAPK2, p41mapk Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end</body> </html> </notes> <label text="ERK*"/> <bbox w="50.0" h="25.0" x="1683.3334" y="2094.6667"/> <glyph class="state variable" id="_d1c97124-7b19-47cd-b94b-b911096839bc"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1675.8334" y="2106.5234"/> </glyph> <glyph class="state variable" id="_681d90ac-9f22-4198-8588-8727991a7d4c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1675.8334" y="2097.2168"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1034_mpk1_mpk1_csa62" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ERK*:KSR1:MEK* Identifiers_end</body> </html> </notes> <label text="ERK*:KSR1:MEK*"/> <bbox w="134.0" h="112.0" x="1835.0" y="2058.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s526_mpk1_mpk1_sa303"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: kinase suppressor of ras 1 "kinase suppressor of ras" KSR HUGO:KSR1 HGNC:6465 ENTREZ:8844 UNIPROT:Q8IVT5 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: KSR1 is a scaffold protein for ERK cascade. It normally localises in the cytosol but after GF treatment it moves to the plasma membrane. Its interaction with MEK1/2 is constitutive. Under endogenous conditions KSR1 facilitates the association of MEK and B-Raf (and not C-Raf) thus promoting MEK and ERK activation (on plasma membrane). PMID:19541618 References_end</body> </html> </notes> <label text="KSR1"/> <bbox w="50.0" h="25.0" x="1852.6666" y="2069.6667"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s527_mpk1_mpk1_sa304"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 1 PRKMK1 HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 mitogen-activated protein kinase kinase 2 PRKMK2 HUGO:MAP2K2 HGNC:6842 ENTREZ:5605 UNIPROT:P36507 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: In resting cells MEK1/2 are localised in the cytoplasm and this may be induced by two molecular mechanisms (i.e.: the presence of a nuclear export domain (NES) in their N-terminal domain; the binding to cytoplasmic anchors such as KSR MP1 beta-ARRESTIN-2 Sef1). MEK1 forms a complex with P14 and MP1 on late endosomes necessary for the activation of ERK pathway in this location of the cell. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19565474 PMID:17178906 PMID:15547943 References_end</body> </html> </notes> <label text="MEK*"/> <bbox w="50.0" h="25.0" x="1896.6666" y="2093.6667"/> <glyph class="state variable" id="_a92fe4ce-d1ff-4891-a5d0-a510f3dbe38c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1889.1666" y="2105.333"/> </glyph> <glyph class="state variable" id="_5d449f91-4ed1-4335-8531-f89e125f39fb"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1889.1666" y="2096.7927"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="mpk1_mpk1_s530_mpk1_mpk1_sa307"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Modelling choices: - ERK represents both ERK1 and ERK2 because it is not completely clear when the two isoforms behave differently. This also happens for the activation on late endosomes: it is known that only ERK1 is activated there, however when ERK1 reaches nucleus, it behaves like ERK2. - Once activated, ERK may either keep being in complex with its activators and scaffolds, or be released in the cytoplasm. In the latter case, it may either dimerise, being able to activate its cytoplasmic targets, or not, being able to translocate to the nucleus. ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1 REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 GENECARDS:MAPK3 KEGG:5595 ATLASONC:MAPK3ID425ch16p11 WIKI:MAPK3 mitogen-activated protein kinase 4 HUGO:MAPK4 HGNC:6878 ENTREZ:5596 UNIPROT:P31152 GENECARDS:MAPK4 KEGG:5596 ATLASONC:MAPK4ID41293ch18q21 WIKI:MAPK4 mitogen-activated protein kinase 6 HUGO:MAPK6 HGNC:6879 ENTREZ:5597 UNIPROT:Q16659 GENECARDS:MAPK6 KEGG:5597 ATLASONC:MAPK6ID43349ch15q21 WIKI:MAPK6 ERK, ERK2, MAPK2, p41mapk Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end</body> </html> </notes> <label text="ERK*"/> <bbox w="50.0" h="25.0" x="1897.0834" y="2119.1667"/> <glyph class="unit of information" id="_72092276-8367-4983-b74d-f2d4d32c4098"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="1912.0834" y="2114.1667"/> </glyph> <glyph class="state variable" id="_02994043-9360-4421-8cdb-167e4aeee07c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1889.5834" y="2131.0234"/> </glyph> <glyph class="state variable" id="_2cb57c32-95a6-4414-a50c-0c794abc5d39"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1889.5834" y="2121.7168"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1035_mpk1_mpk1_csa95" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GADD45*:MAP3K4 Identifiers_end</body> </html> </notes> <label text="GADD45*:MAP3K4"/> <bbox w="127.0" h="84.0" x="3871.9963" y="2233.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s738_mpk1_mpk1_sa511"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: growth arrest and DNA-damage-inducible alpha DDIT1 HUGO:GADD45A HGNC:4095 ENTREZ:1647 UNIPROT:P24522 growth arrest and DNA-damage-inducible beta MYD118 HUGO:GADD45B HGNC:4096 ENTREZ:4616 UNIPROT:O75293 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Expression of GADD45 is the culmination of a signalling pathway that requires prior expression of the tumour suppressor protein P53 which trans-activates the gadd45 gene. P53 expression is in turn driven by the activity of the ATM gene product. GADD45alpha/beta are direct MEKK4 interactors. They are involved in genotoxin regulation of MEKK4 signalling to JNK and P38. PMID:11274345 References_end</body> </html> </notes> <label text="GADD45*"/> <bbox w="75.0" h="25.0" x="3904.4963" y="2239.6667"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s739_mpk1_mpk1_sa512"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 4 MEKK4 HUGO:MAP3K4 HGNC:6856 ENTREZ:4216 UNIPROT:Q9Y6R4 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MEKK4 is a MAP3K and can activate both JNK and P38 pathways. It may be an effector for stress pathways activated by genotoxins. PMID:11274345 References_end</body> </html> </notes> <label text="MAP3K4"/> <bbox w="73.0" h="26.0" x="3901.4963" y="2263.6667"/> <glyph class="state variable" id="_743f2a0c-1013-4c8a-9013-09cca78f56a5"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3893.9963" y="2271.6667"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1036_mpk1_mpk1_csa82" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TAB*:TAK1*:TGFBR1:TGFBR2 Identifiers_end</body> </html> </notes> <label text="TAB*:TAK1*:TGFBR1:TGFBR2"/> <bbox w="199.0" h="85.0" x="3626.9963" y="2238.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s58_mpk1_mpk1_sa459"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 1 MAP3K7IP1 "mitogen-activated protein kinase kinase kinase 7 interacting protein 1" HUGO:TAB1 HGNC:18157 ENTREZ:10454 UNIPROT:Q15750 TGF-beta activated kinase 1/MAP3K7 binding protein 2 MAP3K7IP2 "mitogen-activated protein kinase kinase kinase 7 interacting protein 2" HUGO:TAB2 HGNC:17075 ENTREZ:23118 UNIPROT:Q9NYJ8 TGF-beta activated kinase 1/MAP3K7 binding protein 3 MAP3K7IP3 "mitogen-activated protein kinase kinase kinase 7 interacting protein 3" HUGO:TAB3 HGNC:30681 ENTREZ:257397 UNIPROT:Q8N5C8 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TAK1 is the only MAP3K that requires the adapter proteins TAB123 for its activation. PMID:20060931 References_end</body> </html> </notes> <label text="TAB*"/> <bbox w="50.0" h="25.0" x="3668.163" y="2271.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s59_mpk1_mpk1_sa460"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> </notes> <label text="TAK1*"/> <bbox w="73.0" h="26.0" x="3717.163" y="2270.0"/> <glyph class="state variable" id="_0b02f140-051a-4ee9-9b62-9930ff2a76c8"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="3702.6125" y="2265.0"/> </glyph> <glyph class="state variable" id="_c0e6c0ae-75da-4993-819b-183679a3283b"> <state value="" variable="S192"/> <bbox w="30.0" h="10.0" x="3774.5989" y="2291.0"/> </glyph> <glyph class="state variable" id="_7626ee73-bc3b-4f1f-9444-05e8032fbffe"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3709.663" y="2278.0"/> </glyph> <glyph class="state variable" id="_5338c10e-5a46-4ae7-aca1-bd004c978dd2"> <state value="" variable="T184"/> <bbox w="30.0" h="10.0" x="3702.6125" y="2265.0"/> </glyph> <glyph class="state variable" id="_810bdb33-decc-47e0-bc4d-00f2afd01d87"> <state value="" variable="T178"/> <bbox w="30.0" h="10.0" x="3702.163" y="2290.8196"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s813_mpk1_mpk1_sa575"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transforming growth factor beta receptor 1 "transforming growth factor beta receptor I (activin A receptor type II-like kinase 53kD)" HUGO:TGFBR1 HGNC:11772 ENTREZ:7046 UNIPROT:P36897 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TGF-beta is known to cause a hetero-oligomerisation of the TGFBR1/TGFBR2 complex consisting of two TGFBR1 and two TGFBR2 molecules to activate it (not modelled). Besides cellular stresses the SAPK pathways are also activated by cytokines such as TGF-beta. Smad-dependent gene expression can provoke P38 activation in response to TGFbeta. PMID:20060931 PMID:21614932 References_end</body> </html> </notes> <label text="TGFBR1"/> <bbox w="55.0" h="25.0" x="3668.182" y="2246.4092"/> <glyph class="unit of information" id="_78403223-64b8-4f32-ab10-8277e64fc8ef"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3673.182" y="2241.4092"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s814_mpk1_mpk1_sa576"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transforming growth factor beta receptor II (70/80kDa) MFS2 "transforming growth factor beta receptor II (70-80kD)" HUGO:TGFBR2 HGNC:11773 ENTREZ:7048 UNIPROT:P37173 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TGF-beta is known to cause a hetero-oligomerisation of the TGFBR1/TGFBR2 complex consisting of two TGFBR1 and two TGFBR2 molecules to activate it (not modelled). Besides cellular stresses the SAPK pathways are also activated by cytokines such as TGF-beta. Smad-dependent gene expression can provoke P38 activation in response to TGFbeta. PMID:20060931 PMID:21614932 References_end</body> </html> </notes> <label text="TGFBR2"/> <bbox w="55.0" h="25.0" x="3724.182" y="2247.4092"/> <glyph class="unit of information" id="_1186c901-4475-4f35-968f-2250e33d1127"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3729.182" y="2242.4092"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1037_mpk1_mpk1_csa96" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MAP3K5:TXN Identifiers_end</body> </html> </notes> <label text="MAP3K5:TXN"/> <bbox w="107.0" h="85.0" x="3434.9963" y="1977.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s602_mpk1_mpk1_sa513"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: thioredoxin HUGO:TXN HGNC:12435 ENTREZ:7295 UNIPROT:P10599 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TNF-dependent production of ROS triggers the dissociation of Trx from ASK1 and the consequently liberalised ASK1 binds to TRAF2. Finally TRAF2 appears to activate ASK1 (by phosphorylation) by enhancing and stabilising the oligomerisation of ASK1. PMID:12655147 References_end</body> </html> </notes> <label text="TXN"/> <bbox w="50.0" h="25.0" x="3463.4963" y="1986.3333"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s713_mpk1_mpk1_sa514"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 5 MEKK5 HUGO:MAP3K5 HGNC:6857 ENTREZ:4217 UNIPROT:Q99683 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ASK1 is a MAP3K and can activate both JNK and P38 pathways. TNF-dependent production of ROS triggers the dissociation of Trx from ASK1 and the consequently liberalised ASK1 binds to TRAF2. Finally TRAF2 appears to activate ASK1 (by phosphorylation) by enhancing and stabilising the oligomerisation of ASK1. PMID:11274345 PMID:12655147 References_end</body> </html> </notes> <label text="MAP3K5"/> <bbox w="76.0" h="25.0" x="3452.4963" y="2012.3333"/> <glyph class="state variable" id="_f350a54b-ed75-4ab2-bb70-4f19d74aa811"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3447.4963" y="2019.8333"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1038_mpk1_mpk1_csa83" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:IL1R1:IRAK1:MYD88:TAK1*:TRAF6 Identifiers_end</body> </html> </notes> <label text="IL1R1:IRAK1:MYD88:TAK1*:TRAF6"/> <bbox w="256.0" h="88.0" x="3885.9963" y="2098.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s65_mpk1_mpk1_sa462"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: interleukin-1 receptor-associated kinase 1 HUGO:IRAK1 HGNC:6112 ENTREZ:3654 UNIPROT:P51617 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Similar to RIP recruitment by TRADD the death domain of receptor-bound MyD88 binds IRAK1. PMID:11274345 References_end</body> </html> </notes> <label text="IRAK1"/> <bbox w="50.0" h="25.0" x="3980.9194" y="2132.6538"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s64_mpk1_mpk1_sa463"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: myeloid differentiation primary response 88 "myeloid differentiation primary response gene (88)" HUGO:MYD88 HGNC:7562 ENTREZ:4615 UNIPROT:Q99836 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: The IL-1R/IL-1RAcP heterodimer recruits the death domain adapter protein MyD88. PMID:11274345 References_end</body> </html> </notes> <label text="MYD88"/> <bbox w="64.0" h="25.0" x="3917.9194" y="2132.6538"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s63_mpk1_mpk1_sa464"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TNF receptor-associated factor 6 E3 ubiquitin protein ligase "TNF receptor-associated factor 6" HUGO:TRAF6 HGNC:12036 ENTREZ:7189 UNIPROT:Q9Y4K3 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Upon recruitment to the IL-1R complex IRAK1 binds TRAF6 forming a MyD88-IRAK1-TRAF6 complex analogous to the TNFR-associated complex of TRADD RIP and TRAF2. PMID:11274345 References_end</body> </html> </notes> <label text="TRAF6"/> <bbox w="50.0" h="25.0" x="3974.9194" y="2106.6538"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s60_mpk1_mpk1_sa465"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> </notes> <label text="TAK1*"/> <bbox w="76.0" h="25.0" x="4031.9194" y="2133.2307"/> <glyph class="state variable" id="_4ddd2850-1a3f-4c91-a1a0-e84b1f711fb0"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="4017.3872" y="2128.2307"/> </glyph> <glyph class="state variable" id="_8efa06f0-d368-4b9d-a93e-60db7f29eb9f"> <state value="" variable="S192"/> <bbox w="30.0" h="10.0" x="4092.332" y="2153.2307"/> </glyph> <glyph class="state variable" id="_4032d5ec-5497-446f-8e1a-cc1a7c10b002"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4024.4194" y="2140.7307"/> </glyph> <glyph class="state variable" id="_8ead95ec-a163-4f84-9b24-673a38eb7296"> <state value="" variable="T184"/> <bbox w="30.0" h="10.0" x="4017.3872" y="2128.2307"/> </glyph> <glyph class="state variable" id="_80212277-47ad-42a2-9b0d-313c8225135e"> <state value="" variable="T178"/> <bbox w="30.0" h="10.0" x="4016.9194" y="2153.0571"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s812_mpk1_mpk1_sa574"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: interleukin 1 receptor type I IL1R IL1RA HUGO:IL1R1 HGNC:5993 ENTREZ:3554 UNIPROT:P14778 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: IL-1 likely requires TRAF6 to signal to the SAPKs. IL-1 binding to its receptor (IL-1R) triggers heterodimerisation of IL-1R with IL-1RAcP (not modelled) a transmembrane protein necessary for IL-1 signal transduction. The IL-1R/IL-1RAcP heterodimer then recruits the death domain adapter protein MyD88. PMID:11274345 References_end</body> </html> </notes> <label text="IL1R1"/> <bbox w="50.0" h="25.0" x="3925.182" y="2108.9092"/> <glyph class="unit of information" id="_0afa81c6-d477-4266-b391-93617e683c48"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3927.682" y="2103.9092"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1039_mpk1_mpk1_csa84" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GRB2:MAP3K10_11*:RAC1:RTK*:SOS* Identifiers_end</body> </html> </notes> <label text="GRB2:MAP3K10_11*:RAC1:RTK*:SOS*"/> <bbox w="240.0" h="108.0" x="2855.9963" y="1961.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s632_mpk1_mpk1_sa470"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 10 MLK2 HUGO:MAP3K10 HGNC:6849 ENTREZ:4294 UNIPROT:Q02779 mitogen-activated protein kinase kinase kinase 11 MLK3 PTK1 HUGO:MAP3K11 HGNC:6850 ENTREZ:4296 UNIPROT:Q16584 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MLK3 and MLK2 two MAP3Ks of JNK pathway can interact with RAC1 in a GTP-dependent manner. MLK3 has the potential to positively regulate the ERK/MODULE:MAPK pathway by directly phosphorylating and activating MEK. PMID:11274345 PMID:12738796 References_end</body> </html> </notes> <label text="MAP3K10_11*"/> <bbox w="102.0" h="26.0" x="2873.4963" y="2016.0"/> <glyph class="state variable" id="_34757284-5883-45f7-97bc-82f77c6dc68a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2865.9963" y="2024.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s886_mpk1_mpk1_sa646"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> </notes> <label text="RTK*"/> <bbox w="50.0" h="25.0" x="3031.125" y="1970.75"/> <glyph class="state variable" id="_88363e41-aaf9-4cc3-ac60-dca490e00675"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3076.125" y="1983.4276"/> </glyph> <glyph class="state variable" id="_7c643381-91b3-4fee-a207-52818f6c884f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3076.125" y="1983.4276"/> </glyph> <glyph class="state variable" id="_b2952d20-33e6-40e5-9779-eaf19d4b88e8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3076.125" y="1978.25"/> </glyph> <glyph class="unit of information" id="_75184562-101c-4b16-a10c-f3056043e848"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3033.625" y="1965.75"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s884_mpk1_mpk1_sa647"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 References_end Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 GENECARDS:GRB2 REACTOME:404631 KEGG:2885 ATLASONC:GRB2ID386ch17q25 WIKI:GRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="GRB2"/> <bbox w="50.0" h="25.0" x="3030.125" y="1992.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s885_mpk1_mpk1_sa648"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 References_end Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 GENECARDS:SOS1 REACTOME:64848 KEGG:6654 ATLASONC:GC_SOS1 WIKI:SOS1 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 GENECARDS:SOS2 REACTOME:64850 ATLASONC:GC_SOS2 WIKI:SOS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="SOS*"/> <bbox w="50.0" h="25.0" x="3030.125" y="2017.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s630_mpk1_mpk1_sa650"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <bbox w="60.0" h="25.0" x="2972.625" y="2016.25"/> <glyph class="state variable" id="_443b46ee-a623-4699-bce3-7aed19941d40"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2965.125" y="2023.75"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1040_mpk1_mpk1_csa100" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GRB2:MAP3K2_3*:RAS*:RTK*:SOS* Identifiers_end</body> </html> </notes> <label text="GRB2:MAP3K2_3*:RAS*:RTK*:SOS*"/> <bbox w="227.0" h="103.0" x="3160.9963" y="1962.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s580_mpk1_mpk1_sa529"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 2 MEKK2 HUGO:MAP3K2 HGNC:6854 ENTREZ:10746 UNIPROT:Q9Y2U5 mitogen-activated protein kinase kinase kinase 3 MEKK3 HUGO:MAP3K3 HGNC:6855 ENTREZ:4215 UNIPROT:Q99759 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MEKK2 and MEKK3 can activate JNK P38 and ERK pathways PMID:11274345 References_end</body> </html> </notes> <label text="MAP3K2_3*"/> <bbox w="76.0" h="25.0" x="3178.4963" y="2016.3333"/> <glyph class="state variable" id="_9b64b25d-c014-488f-887c-c4e46b70ad5b"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3170.9963" y="2023.8333"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s882_mpk1_mpk1_sa642"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> </notes> <label text="RTK*"/> <bbox w="50.0" h="25.0" x="3320.125" y="1968.75"/> <glyph class="state variable" id="_73c40199-e54d-47ef-8b96-f1c8ebb3875a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3365.125" y="1981.4276"/> </glyph> <glyph class="state variable" id="_bad60114-be31-44e9-9fd8-9be1db0097b4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3365.125" y="1981.4276"/> </glyph> <glyph class="state variable" id="_1a16377b-f434-4f3a-9483-3db1a1badcf3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3365.125" y="1976.25"/> </glyph> <glyph class="unit of information" id="_3035294a-462b-4faf-acaa-4a9d8941d452"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3322.625" y="1963.75"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s880_mpk1_mpk1_sa643"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 References_end Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 GENECARDS:GRB2 REACTOME:404631 KEGG:2885 ATLASONC:GRB2ID386ch17q25 WIKI:GRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="GRB2"/> <bbox w="50.0" h="25.0" x="3319.125" y="1990.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s881_mpk1_mpk1_sa644"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 References_end Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 GENECARDS:SOS1 REACTOME:64848 KEGG:6654 ATLASONC:GC_SOS1 WIKI:SOS1 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 GENECARDS:SOS2 REACTOME:64850 ATLASONC:GC_SOS2 WIKI:SOS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="SOS*"/> <bbox w="50.0" h="25.0" x="3319.125" y="2015.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s879_mpk1_mpk1_sa645"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> </notes> <label text="RAS*"/> <bbox w="50.0" h="25.0" x="3270.625" y="2015.75"/> <glyph class="state variable" id="_bafa6e0d-454f-47cb-b325-fe7f72f0bd2a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3263.125" y="2023.25"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1041_mpk1_mpk1_csa89" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GRB2:MAP3K1:RAS*:RTK*:SOS* Identifiers_end</body> </html> </notes> <label text="GRB2:MAP3K1:RAS*:RTK*:SOS*"/> <bbox w="205.0" h="103.0" x="3368.1504" y="2114.4614"/> <glyph class="macromolecule" id="mpk1_mpk1_s95_mpk1_mpk1_sa487"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 1 E3 ubiquitin protein ligase MEKK1 "mitogen-activated protein kinase kinase kinase 1" HUGO:MAP3K1 HGNC:6848 ENTREZ:4214 UNIPROT:Q13233 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MEKK1 (MAP3K1) is a key MAP3K. MEKK1 is significantly activated by TNF. Oligomerisation of TRAFs is sufficient to trigger MEKK1 binding. MEKK1 associates selectively with oligomerised TRAF2 in vivo in a TNF-dependent manner. MEKK1 can interact with Ras in a GTP-dependent manner. The GTP-dependent coupling of MEKK1 to Ras indicates that MEKK1 may be an effector for those agonists that recruit JNK through Ras-dependent mechanisms. MEKK1 selectively activates the endogenous JNK pathway. MEKK1 can activate MEK4 and MEK7 in vivo. PMID:18855897 PMID:11274345 References_end</body> </html> </notes> <label text="MAP3K1"/> <bbox w="76.0" h="25.0" x="3382.1504" y="2167.4614"/> <glyph class="state variable" id="_647da0aa-3fe1-4354-8daf-591b90172718"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3374.6504" y="2174.9614"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s877_mpk1_mpk1_sa638"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> </notes> <label text="RTK*"/> <bbox w="50.0" h="25.0" x="3511.125" y="2120.75"/> <glyph class="state variable" id="_c2a19b63-72d8-45a2-a89e-8791501c9b5d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3556.125" y="2133.4277"/> </glyph> <glyph class="state variable" id="_6068562f-b2e0-4967-9cdf-836fbe894622"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3556.125" y="2133.4277"/> </glyph> <glyph class="state variable" id="_0c4dfe14-e2fe-4aee-8274-e43227da5ccf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3556.125" y="2128.25"/> </glyph> <glyph class="unit of information" id="_09f8676d-e957-4f9b-a9ba-a08deb51b219"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3513.625" y="2115.75"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s567_mpk1_mpk1_sa639"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 References_end Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 GENECARDS:GRB2 REACTOME:404631 KEGG:2885 ATLASONC:GRB2ID386ch17q25 WIKI:GRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="GRB2"/> <bbox w="50.0" h="25.0" x="3511.125" y="2143.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s568_mpk1_mpk1_sa640"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 References_end Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 GENECARDS:SOS1 REACTOME:64848 KEGG:6654 ATLASONC:GC_SOS1 WIKI:SOS1 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 GENECARDS:SOS2 REACTOME:64850 ATLASONC:GC_SOS2 WIKI:SOS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="SOS*"/> <bbox w="50.0" h="25.0" x="3511.125" y="2168.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s878_mpk1_mpk1_sa641"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> </notes> <label text="RAS*"/> <bbox w="50.0" h="25.0" x="3461.625" y="2167.75"/> <glyph class="state variable" id="_ce79a173-9057-4904-a1ef-353088731c2c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3454.125" y="2175.25"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1042_mpk1_mpk1_csa97" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MAP3K1:TNFRSF1B:TRAF2 Identifiers_end</body> </html> </notes> <label text="MAP3K1:TNFRSF1B:TRAF2"/> <bbox w="180.0" h="86.0" x="3167.9963" y="2240.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s103_mpk1_mpk1_sa516"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TNF receptor-associated factor 2 HUGO:TRAF2 HGNC:12032 ENTREZ:7186 UNIPROT:Q12933 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TRAF proteins are recruited to the TRADD-TNFR1 complex. TRADD couples TNFR1 to TRAF2. TRAF2 directly interacts with TNFR2. ERN1 activation is likely to trigger binding and activation of TRAF2. PMID:11274345 References_end</body> </html> </notes> <label text="TRAF2"/> <bbox w="50.0" h="25.0" x="3195.9194" y="2272.923"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s105_mpk1_mpk1_sa517"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 1 E3 ubiquitin protein ligase MEKK1 "mitogen-activated protein kinase kinase kinase 1" HUGO:MAP3K1 HGNC:6848 ENTREZ:4214 UNIPROT:Q13233 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MEKK1 (MAP3K1) is a key MAP3K. MEKK1 is significantly activated by TNF. Oligomerisation of TRAFs is sufficient to trigger MEKK1 binding. MEKK1 associates selectively with oligomerised TRAF2 in vivo in a TNF-dependent manner. MEKK1 can interact with Ras in a GTP-dependent manner. The GTP-dependent coupling of MEKK1 to Ras indicates that MEKK1 may be an effector for those agonists that recruit JNK through Ras-dependent mechanisms. MEKK1 selectively activates the endogenous JNK pathway. MEKK1 can activate MEK4 and MEK7 in vivo. PMID:18855897 PMID:11274345 References_end</body> </html> </notes> <label text="MAP3K1"/> <bbox w="73.0" h="26.0" x="3254.9963" y="2272.6152"/> <glyph class="state variable" id="_31e1a825-001e-420c-85ef-218fedd380ed"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3247.4963" y="2280.6152"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s806_mpk1_mpk1_sa565"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tumor necrosis factor receptor superfamily member 1B TNFR2 HUGO:TNFRSF1B HGNC:11917 ENTREZ:7133 UNIPROT:P20333 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins (TRAF2). PMID:11274345 References_end</body> </html> </notes> <label text="TNFRSF1B"/> <bbox w="70.0" h="25.0" x="3189.9092" y="2249.9092"/> <glyph class="unit of information" id="_63e7c67e-3d4b-414c-b8f3-d94b99deacc4"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3202.4092" y="2244.9092"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1043_mpk1_mpk1_csa98" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MAP3K5:TNFRSF1B:TRAF2 Identifiers_end</body> </html> </notes> <label text="MAP3K5:TNFRSF1B:TRAF2"/> <bbox w="180.0" h="83.0" x="3397.9963" y="2242.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s773_mpk1_mpk1_sa520"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TNF receptor-associated factor 2 HUGO:TRAF2 HGNC:12032 ENTREZ:7186 UNIPROT:Q12933 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TRAF proteins are recruited to the TRADD-TNFR1 complex. TRADD couples TNFR1 to TRAF2. TRAF2 directly interacts with TNFR2. ERN1 activation is likely to trigger binding and activation of TRAF2. PMID:11274345 References_end</body> </html> </notes> <label text="TRAF2"/> <bbox w="50.0" h="25.0" x="3420.163" y="2274.3333"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s811_mpk1_mpk1_sa573"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tumor necrosis factor receptor superfamily member 1B TNFR2 HUGO:TNFRSF1B HGNC:11917 ENTREZ:7133 UNIPROT:P20333 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins (TRAF2). PMID:11274345 References_end</body> </html> </notes> <label text="TNFRSF1B"/> <bbox w="70.0" h="25.0" x="3417.3635" y="2252.9092"/> <glyph class="unit of information" id="_b7b36c0c-1391-4733-b335-f0bec65ae5b3"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3429.8635" y="2247.9092"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s872_mpk1_mpk1_sa633"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 5 MEKK5 HUGO:MAP3K5 HGNC:6857 ENTREZ:4217 UNIPROT:Q99683 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ASK1 is a MAP3K and can activate both JNK and P38 pathways. TNF-dependent production of ROS triggers the dissociation of Trx from ASK1 and the consequently liberalised ASK1 binds to TRAF2. Finally TRAF2 appears to activate ASK1 (by phosphorylation) by enhancing and stabilising the oligomerisation of ASK1. PMID:11274345 PMID:12655147 References_end</body> </html> </notes> <label text="MAP3K5"/> <bbox w="73.0" h="26.0" x="3478.375" y="2274.5"/> <glyph class="state variable" id="_9d45d424-d19c-44fc-be9a-25bb9f599022"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3470.875" y="2282.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1044_mpk1_mpk1_csa85" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TAK1*:TNFRSF1B:TRAF2 Identifiers_end</body> </html> </notes> <label text="TAK1*:TNFRSF1B:TRAF2"/> <bbox w="179.0" h="85.0" x="3624.9963" y="2096.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s873_mpk1_mpk1_sa634"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TNF receptor-associated factor 2 HUGO:TRAF2 HGNC:12032 ENTREZ:7186 UNIPROT:Q12933 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TRAF proteins are recruited to the TRADD-TNFR1 complex. TRADD couples TNFR1 to TRAF2. TRAF2 directly interacts with TNFR2. ERN1 activation is likely to trigger binding and activation of TRAF2. PMID:11274345 References_end</body> </html> </notes> <label text="TRAF2"/> <bbox w="50.0" h="25.0" x="3648.375" y="2127.5"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s874_mpk1_mpk1_sa635"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tumor necrosis factor receptor superfamily member 1B TNFR2 HUGO:TNFRSF1B HGNC:11917 ENTREZ:7133 UNIPROT:P20333 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins (TRAF2). PMID:11274345 References_end</body> </html> </notes> <label text="TNFRSF1B"/> <bbox w="70.0" h="25.0" x="3643.375" y="2104.5"/> <glyph class="unit of information" id="_538746fc-8282-4f3b-aad5-55fe74e168eb"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3655.875" y="2099.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s875_mpk1_mpk1_sa636"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> </notes> <label text="TAK1*"/> <bbox w="76.0" h="25.0" x="3707.375" y="2127.5"/> <glyph class="state variable" id="_85e4545c-f9b4-4c75-9d4d-edae32c10528"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="3692.8428" y="2122.5"/> </glyph> <glyph class="state variable" id="_95895826-3144-4eb8-8772-ceb7a78da3a5"> <state value="" variable="S192"/> <bbox w="30.0" h="10.0" x="3767.7876" y="2147.5"/> </glyph> <glyph class="state variable" id="_5d1e1c51-010a-4933-873a-4525e1a56635"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3699.875" y="2135.0"/> </glyph> <glyph class="state variable" id="_b5a7de68-0ffb-4160-8c71-e263a4f451f0"> <state value="" variable="T184"/> <bbox w="30.0" h="10.0" x="3692.8428" y="2122.5"/> </glyph> <glyph class="state variable" id="_9cd27030-5405-4015-b6ac-4f159ac5f598"> <state value="" variable="T178"/> <bbox w="30.0" h="10.0" x="3692.375" y="2147.3264"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1045_mpk1_mpk1_csa94" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MAP3K2_3*:TNFRSF1B:TRAF2 Identifiers_end</body> </html> </notes> <label text="MAP3K2_3*:TNFRSF1B:TRAF2"/> <bbox w="192.0" h="83.0" x="2834.9963" y="2120.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s737_mpk1_mpk1_sa510"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TNF receptor-associated factor 2 HUGO:TRAF2 HGNC:12032 ENTREZ:7186 UNIPROT:Q12933 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TRAF proteins are recruited to the TRADD-TNFR1 complex. TRADD couples TNFR1 to TRAF2. TRAF2 directly interacts with TNFR2. ERN1 activation is likely to trigger binding and activation of TRAF2. PMID:11274345 References_end</body> </html> </notes> <label text="TRAF2"/> <bbox w="50.0" h="25.0" x="2866.4963" y="2152.6667"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s807_mpk1_mpk1_sa569"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tumor necrosis factor receptor superfamily member 1B TNFR2 HUGO:TNFRSF1B HGNC:11917 ENTREZ:7133 UNIPROT:P20333 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins (TRAF2). PMID:11274345 References_end</body> </html> </notes> <label text="TNFRSF1B"/> <bbox w="70.0" h="25.0" x="2862.0908" y="2128.9092"/> <glyph class="unit of information" id="_faa610af-4a33-46b9-99dd-9e90765d964a"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2874.5908" y="2123.9092"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s876_mpk1_mpk1_sa637"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 2 MEKK2 HUGO:MAP3K2 HGNC:6854 ENTREZ:10746 UNIPROT:Q9Y2U5 mitogen-activated protein kinase kinase kinase 3 MEKK3 HUGO:MAP3K3 HGNC:6855 ENTREZ:4215 UNIPROT:Q99759 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MEKK2 and MEKK3 can activate JNK P38 and ERK pathways PMID:11274345 References_end</body> </html> </notes> <label text="MAP3K2_3*"/> <bbox w="102.0" h="26.0" x="2919.625" y="2152.0"/> <glyph class="state variable" id="_7e900b59-59a9-4276-95df-090d4872d20c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2912.125" y="2160.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1046_mpk1_mpk1_csa90" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MAP3K1:RIPK1:TNFRSF1A:TRADD:TRAF2 Identifiers_end</body> </html> </notes> <label text="MAP3K1:RIPK1:TNFRSF1A:TRADD:TRAF2"/> <bbox w="271.0" h="86.0" x="3051.9963" y="2114.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s99_mpk1_mpk1_sa489"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TNF receptor-associated factor 2 HUGO:TRAF2 HGNC:12032 ENTREZ:7186 UNIPROT:Q12933 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TRAF proteins are recruited to the TRADD-TNFR1 complex. TRADD couples TNFR1 to TRAF2. TRAF2 directly interacts with TNFR2. ERN1 activation is likely to trigger binding and activation of TRAF2. PMID:11274345 References_end</body> </html> </notes> <label text="TRAF2"/> <bbox w="50.0" h="25.0" x="3106.3042" y="2147.3848"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s98_mpk1_mpk1_sa490"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TNFRSF1A-associated via death domain HUGO:TRADD HGNC:12030 ENTREZ:8717 UNIPROT:Q15628 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins. PMID:11274345 References_end</body> </html> </notes> <label text="TRADD"/> <bbox w="57.0" h="25.0" x="3168.3042" y="2121.3848"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s101_mpk1_mpk1_sa491"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: receptor (TNFRSF)-interacting serine-threonine kinase 1 HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TNF treatment is thought to result in the formation of a TRADD-RIP-TRAF2 complex at the membrane. PMID:11274345 References_end</body> </html> </notes> <label text="RIPK1"/> <bbox w="50.0" h="25.0" x="3156.3042" y="2147.3848"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s96_mpk1_mpk1_sa492"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 1 E3 ubiquitin protein ligase MEKK1 "mitogen-activated protein kinase kinase kinase 1" HUGO:MAP3K1 HGNC:6848 ENTREZ:4214 UNIPROT:Q13233 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MEKK1 (MAP3K1) is a key MAP3K. MEKK1 is significantly activated by TNF. Oligomerisation of TRAFs is sufficient to trigger MEKK1 binding. MEKK1 associates selectively with oligomerised TRAF2 in vivo in a TNF-dependent manner. MEKK1 can interact with Ras in a GTP-dependent manner. The GTP-dependent coupling of MEKK1 to Ras indicates that MEKK1 may be an effector for those agonists that recruit JNK through Ras-dependent mechanisms. MEKK1 selectively activates the endogenous JNK pathway. MEKK1 can activate MEK4 and MEK7 in vivo. PMID:18855897 PMID:11274345 References_end</body> </html> </notes> <label text="MAP3K1"/> <bbox w="76.0" h="25.0" x="3208.3042" y="2147.3848"/> <glyph class="state variable" id="_46119a2b-bb82-453f-8180-4a01a5fbcfef"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3200.8042" y="2154.8848"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s808_mpk1_mpk1_sa570"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tumor necrosis factor receptor superfamily member 1A TNFR1 HUGO:TNFRSF1A HGNC:11916 ENTREZ:7132 UNIPROT:P19438 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins. PMID:11274345 References_end</body> </html> </notes> <label text="TNFRSF1A"/> <bbox w="70.0" h="25.0" x="3097.5454" y="2123.9092"/> <glyph class="unit of information" id="_cbcf41c8-339a-426a-bc3e-ed79301be945"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3110.0454" y="2118.9092"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1047_mpk1_mpk1_csa93" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:RIPK1:TAK1*:TNFRSF1A:TRADD:TRAF2 Identifiers_end</body> </html> </notes> <label text="RIPK1:TAK1*:TNFRSF1A:TRADD:TRAF2"/> <bbox w="275.0" h="87.0" x="3568.9963" y="1984.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s777_mpk1_mpk1_sa498"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TNF receptor-associated factor 2 HUGO:TRAF2 HGNC:12032 ENTREZ:7186 UNIPROT:Q12933 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TRAF proteins are recruited to the TRADD-TNFR1 complex. TRADD couples TNFR1 to TRAF2. TRAF2 directly interacts with TNFR2. ERN1 activation is likely to trigger binding and activation of TRAF2. PMID:11274345 References_end</body> </html> </notes> <label text="TRAF2"/> <bbox w="50.0" h="25.0" x="3620.4963" y="2018.6667"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s774_mpk1_mpk1_sa500"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TNFRSF1A-associated via death domain HUGO:TRADD HGNC:12030 ENTREZ:8717 UNIPROT:Q15628 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins. PMID:11274345 References_end</body> </html> </notes> <label text="TRADD"/> <bbox w="56.0" h="25.0" x="3679.4963" y="1990.6667"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s775_mpk1_mpk1_sa501"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: receptor (TNFRSF)-interacting serine-threonine kinase 1 HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TNF treatment is thought to result in the formation of a TRADD-RIP-TRAF2 complex at the membrane. PMID:11274345 References_end</body> </html> </notes> <label text="RIPK1"/> <bbox w="50.0" h="25.0" x="3668.4963" y="2017.6667"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s736_mpk1_mpk1_sa507"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> </notes> <label text="TAK1*"/> <bbox w="76.0" h="25.0" x="3719.0732" y="2017.9231"/> <glyph class="state variable" id="_bfa6c8f7-0d6a-4f8d-91a0-264b0ed7a0dc"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="3704.541" y="2012.9231"/> </glyph> <glyph class="state variable" id="_b6e9a494-0d00-458d-917a-beffc8d694d0"> <state value="" variable="S192"/> <bbox w="30.0" h="10.0" x="3779.4858" y="2037.9231"/> </glyph> <glyph class="state variable" id="_dee03eac-929e-4754-8e2e-ec6574e9c7ef"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3711.5732" y="2025.4231"/> </glyph> <glyph class="state variable" id="_006a3fa5-c134-4342-8022-4861ff15974c"> <state value="" variable="T184"/> <bbox w="30.0" h="10.0" x="3704.541" y="2012.9231"/> </glyph> <glyph class="state variable" id="_837d2a9d-80ec-4e0a-bcb1-a41aca01c667"> <state value="" variable="T178"/> <bbox w="30.0" h="10.0" x="3704.0732" y="2037.7495"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s776_mpk1_mpk1_sa564"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tumor necrosis factor receptor superfamily member 1A TNFR1 HUGO:TNFRSF1A HGNC:11916 ENTREZ:7132 UNIPROT:P19438 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins. PMID:11274345 References_end</body> </html> </notes> <label text="TNFRSF1A"/> <bbox w="70.0" h="25.0" x="3611.9092" y="1994.9092"/> <glyph class="unit of information" id="_f327b816-765f-4a04-85bd-bc1f933a90d9"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3624.4092" y="1989.9092"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1048_mpk1_mpk1_csa91" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MAP3K5:RIPK1:TNFRSF1A:TRADD:TRAF2 Identifiers_end</body> </html> </notes> <label text="MAP3K5:RIPK1:TNFRSF1A:TRADD:TRAF2"/> <bbox w="271.0" h="87.0" x="3903.9963" y="1975.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s731_mpk1_mpk1_sa493"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TNFRSF1A-associated via death domain HUGO:TRADD HGNC:12030 ENTREZ:8717 UNIPROT:Q15628 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins. PMID:11274345 References_end</body> </html> </notes> <label text="TRADD"/> <bbox w="50.0" h="25.0" x="4027.163" y="1984.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s611_mpk1_mpk1_sa495"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TNF receptor-associated factor 2 HUGO:TRAF2 HGNC:12032 ENTREZ:7186 UNIPROT:Q12933 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TRAF proteins are recruited to the TRADD-TNFR1 complex. TRADD couples TNFR1 to TRAF2. TRAF2 directly interacts with TNFR2. ERN1 activation is likely to trigger binding and activation of TRAF2. PMID:11274345 References_end</body> </html> </notes> <label text="TRAF2"/> <bbox w="50.0" h="25.0" x="3965.163" y="2010.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s612_mpk1_mpk1_sa496"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: receptor (TNFRSF)-interacting serine-threonine kinase 1 HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TNF treatment is thought to result in the formation of a TRADD-RIP-TRAF2 complex at the membrane. PMID:11274345 References_end</body> </html> </notes> <label text="RIPK1"/> <bbox w="50.0" h="25.0" x="4014.163" y="2009.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s767_mpk1_mpk1_sa497"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 5 MEKK5 HUGO:MAP3K5 HGNC:6857 ENTREZ:4217 UNIPROT:Q99683 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ASK1 is a MAP3K and can activate both JNK and P38 pathways. TNF-dependent production of ROS triggers the dissociation of Trx from ASK1 and the consequently liberalised ASK1 binds to TRAF2. Finally TRAF2 appears to activate ASK1 (by phosphorylation) by enhancing and stabilising the oligomerisation of ASK1. PMID:11274345 PMID:12655147 References_end</body> </html> </notes> <label text="MAP3K5"/> <bbox w="76.0" h="25.0" x="4065.163" y="2009.0"/> <glyph class="state variable" id="_e57dbaea-f059-4633-a05f-a4073f3cc856"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4057.663" y="2016.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s893_mpk1_mpk1_sa651"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tumor necrosis factor receptor superfamily member 1A TNFR1 HUGO:TNFRSF1A HGNC:11916 ENTREZ:7132 UNIPROT:P19438 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins. PMID:11274345 References_end</body> </html> </notes> <label text="TNFRSF1A"/> <bbox w="70.0" h="25.0" x="3957.0" y="1985.3333"/> <glyph class="unit of information" id="_3a9c70eb-37ba-4803-9db0-c34ebd836f61"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3969.5" y="1980.3333"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1049_mpk1_mpk1_csa92" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MAP3K2_3*:RIPK1:TNFRSF1A:TRADD:TRAF2 Identifiers_end</body> </html> </notes> <label text="MAP3K2_3*:RIPK1:TNFRSF1A:TRADD:TRAF2"/> <bbox w="292.0" h="86.0" x="2844.9963" y="2243.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s733_mpk1_mpk1_sa504"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TNF receptor-associated factor 2 HUGO:TRAF2 HGNC:12032 ENTREZ:7186 UNIPROT:Q12933 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TRAF proteins are recruited to the TRADD-TNFR1 complex. TRADD couples TNFR1 to TRAF2. TRAF2 directly interacts with TNFR2. ERN1 activation is likely to trigger binding and activation of TRAF2. PMID:11274345 References_end</body> </html> </notes> <label text="TRAF2"/> <bbox w="50.0" h="25.0" x="2896.381" y="2277.6152"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s735_mpk1_mpk1_sa505"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: receptor (TNFRSF)-interacting serine-threonine kinase 1 HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TNF treatment is thought to result in the formation of a TRADD-RIP-TRAF2 complex at the membrane. PMID:11274345 References_end</body> </html> </notes> <label text="RIPK1"/> <bbox w="50.0" h="25.0" x="2946.381" y="2277.6152"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s734_mpk1_mpk1_sa506"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TNFRSF1A-associated via death domain HUGO:TRADD HGNC:12030 ENTREZ:8717 UNIPROT:Q15628 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins. PMID:11274345 References_end</body> </html> </notes> <label text="TRADD"/> <bbox w="61.0" h="24.0" x="2958.381" y="2251.6152"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s587_mpk1_mpk1_sa539"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 2 MEKK2 HUGO:MAP3K2 HGNC:6854 ENTREZ:10746 UNIPROT:Q9Y2U5 mitogen-activated protein kinase kinase kinase 3 MEKK3 HUGO:MAP3K3 HGNC:6855 ENTREZ:4215 UNIPROT:Q99759 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MEKK2 and MEKK3 can activate JNK P38 and ERK pathways PMID:11274345 References_end</body> </html> </notes> <label text="MAP3K2_3*"/> <bbox w="102.0" h="26.0" x="2998.3845" y="2277.2307"/> <glyph class="state variable" id="_0df7b115-0b21-4130-82b7-bc55f85e33b3"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2990.8845" y="2285.2307"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s809_mpk1_mpk1_sa571"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tumor necrosis factor receptor superfamily member 1A TNFR1 HUGO:TNFRSF1A HGNC:11916 ENTREZ:7132 UNIPROT:P19438 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins. PMID:11274345 References_end</body> </html> </notes> <label text="TNFRSF1A"/> <bbox w="70.0" h="25.0" x="2888.5454" y="2254.9092"/> <glyph class="unit of information" id="_db12cde8-5e85-4487-9966-f57ed87ea810"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2901.0454" y="2249.9092"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1050_mpk1_mpk1_csa105" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATF2:JUN Identifiers_end</body> </html> </notes> <label text="(AP-1*)"/> <bbox w="101.0" h="84.0" x="1707.9965" y="3068.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s784_mpk1_mpk1_sa541"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> </notes> <label text="JUN"/> <bbox w="50.0" h="25.0" x="1735.4286" y="3078.0"/> <glyph class="state variable" id="_ddc1dab0-6dad-4186-87d9-4feba3908c3a"> <state value="" variable="S63"/> <bbox w="25.0" h="10.0" x="1723.2365" y="3073.0"/> </glyph> <glyph class="state variable" id="_120492fc-9ae9-4d02-a79b-4801aac69f03"> <state value="" variable="S73"/> <bbox w="25.0" h="10.0" x="1747.9485" y="3073.0"/> </glyph> <glyph class="state variable" id="_86817738-b20e-402b-b3b6-2cc7ba772bae"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1727.9286" y="3085.5"/> </glyph> <glyph class="state variable" id="_c5b6d22d-c59f-4c50-ba51-f87b880a9885"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1730.4286" y="3073.0"/> </glyph> <glyph class="state variable" id="_5f39ede4-ba8f-4e87-b6cf-230b02cb5356"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1730.4286" y="3098.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s785_mpk1_mpk1_sa542"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: activating transcription factor 2 "cAMP responsive element binding protein 2" CREB2 HUGO:ATF2 HGNC:784 ENTREZ:1386 UNIPROT:P15336 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ATF2 is a nuclear P38 target. ATF2 is a nuclear JNK target. PMID:20506250 PMID:11274345 References_end</body> </html> </notes> <label text="ATF2"/> <bbox w="50.0" h="25.0" x="1735.4286" y="3102.0"/> <glyph class="state variable" id="_1d75bd05-6035-4e76-a4be-8df6a1c44637"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1727.9286" y="3109.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1051_mpk1_mpk1_csa103" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:JUN Identifiers_end</body> </html> </notes> <label text="(AP-1*)"/> <bbox w="103.0" h="58.0" x="1665.9965" y="2897.0"/> <glyph class="macromolecule multimer" id="mpk1_mpk1_s720_mpk1_mpk1_sa534"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> </notes> <label text="JUN"/> <bbox w="50.0" h="25.0" x="1701.1631" y="2904.3335"/> <glyph class="unit of information" id="_a1165b3e-2a62-469e-813e-968729af2da3"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="1716.1631" y="2899.3335"/> </glyph> <glyph class="state variable" id="_af89d4a9-b782-4725-aa8d-146aa41c80a0"> <state value="" variable="S63"/> <bbox w="25.0" h="10.0" x="1688.971" y="2899.3335"/> </glyph> <glyph class="state variable" id="_ae87511b-9d40-407d-9011-d041d2ec09b6"> <state value="" variable="S73"/> <bbox w="25.0" h="10.0" x="1713.683" y="2899.3335"/> </glyph> <glyph class="state variable" id="_bda9a0b3-b5a1-46e2-bbd7-8fcda0d1fcd6"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1693.6631" y="2911.8335"/> </glyph> <glyph class="state variable" id="_ef1b0a08-5d96-4907-9569-1d373f4660e3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1696.1631" y="2899.3335"/> </glyph> <glyph class="state variable" id="_3f84da1b-b37a-4a6e-9aa0-b66d8041d6bd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1696.1631" y="2924.3335"/> </glyph> </glyph> </glyph> <glyph class="complex" id="mpk1_mpk1_s1052_mpk1_mpk1_csa104" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FOS:JUN Identifiers_end</body> </html> </notes> <label text="(AP-1*)"/> <bbox w="108.0" h="88.0" x="1514.9965" y="2968.0"/> <glyph class="macromolecule" id="mpk1_mpk1_s722_mpk1_mpk1_sa535"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> </notes> <label text="JUN"/> <bbox w="50.0" h="25.0" x="1545.1631" y="2978.3335"/> <glyph class="state variable" id="_3aeac8bb-92fa-46d9-9eff-94964b7ca5c7"> <state value="" variable="S63"/> <bbox w="25.0" h="10.0" x="1532.971" y="2973.3335"/> </glyph> <glyph class="state variable" id="_bba02d98-def0-4d44-a171-8731def4159e"> <state value="" variable="S73"/> <bbox w="25.0" h="10.0" x="1557.683" y="2973.3335"/> </glyph> <glyph class="state variable" id="_f8a75ae7-a9fe-46ec-b15a-cda0b491b4a6"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1537.6631" y="2985.8335"/> </glyph> <glyph class="state variable" id="_3b6ab621-8268-4584-85cb-8662c4560a85"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1540.1631" y="2973.3335"/> </glyph> <glyph class="state variable" id="_a204e983-0965-4312-a2b4-11f057a839f8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1540.1631" y="2998.3335"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s783_mpk1_mpk1_sa540"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: FBJ murine osteosarcoma viral oncogene homolog "v-fos FBJ murine osteosarcoma viral oncogene homolog" HUGO:FOS HGNC:3796 ENTREZ:2353 UNIPROT:P01100 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: c-FOS is activated by ERK and RSK through phosphorylation. PMID:16393692 References_end Identifiers_begin: FBJ murine osteosarcoma viral oncogene homolog "v-fos FBJ murine osteosarcoma viral oncogene homolog" HUGO:FOS HGNC:3796 ENTREZ:2353 UNIPROT:P01100 GENECARDS:FOS REACTOME:54964 KEGG:2353 ATLASONC:GC_FOS WIKI:FOS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: c-FOS is activated by ERK and RSK through phosphorylation. PMID:16393692 References_end</body> </html> </notes> <label text="FOS"/> <bbox w="50.0" h="25.0" x="1544.5714" y="3002.0"/> <glyph class="state variable" id="_f32628a1-2074-456b-8ee4-599fc60966c1"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1537.0714" y="3009.5"/> </glyph> </glyph> </glyph> <glyph class="nucleic acid feature" id="mpk1_mpk1_s903_mpk1_mpk1_sa661" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: phorbol-12-myristate-13-acetate-induced protein 1 HUGO:PMAIP1 HGNC:9108 ENTREZ:5366 UNIPROT:Q13794 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end</body> </html> </notes> <label text="PMAIP1"/> <bbox w="70.0" h="25.0" x="3129.0" y="3301.5"/> </glyph> <glyph class="nucleic acid feature" id="mpk1_mpk1_s902_mpk1_mpk1_sa660" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: PERP TP53 apoptosis effector HUGO:PERP HGNC:17637 ENTREZ:64065 UNIPROT:Q96FX8 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end</body> </html> </notes> <label text="PERP"/> <bbox w="70.0" h="25.0" x="3403.0" y="3303.5"/> </glyph> <glyph class="nucleic acid feature" id="mpk1_mpk1_s927_mpk1_mpk1_sa682" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) "v-myc avian myelocytomatosis viral oncogene homolog" HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) "v-myc avian myelocytomatosis viral oncogene homolog" HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 GENECARDS:MYC REACTOME:59773 KEGG:4609 ATLASONC:MYCID27 WIKI:MYC Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) "v-myc avian myelocytomatosis viral oncogene homolog" HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 GENECARDS:MYC REACTOME:59773 KEGG:4609 ATLASONC:MYCID27 WIKI:MYC Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MYC"/> <bbox w="70.0" h="25.0" x="2825.0" y="3337.5"/> </glyph> <glyph class="nucleic acid feature" id="mpk1_mpk1_s898_mpk1_mpk1_sa656" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: matrix metallopeptidase 13 (collagenase 3) "matrix metalloproteinase 13 (collagenase 3)" HUGO:MMP13 HGNC:7159 ENTREZ:4322 UNIPROT:P45452 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end</body> </html> </notes> <label text="MMP13"/> <bbox w="70.0" h="25.0" x="460.0" y="3328.5"/> </glyph> <glyph class="nucleic acid feature" id="mpk1_mpk1_s901_mpk1_mpk1_sa659" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 GENECARDS:MDM2 REACTOME:95018 KEGG:4193 ATLASONC:MDM2ID115ch12q15 WIKI:MDM2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20679392 PMID:15169778 PMID:11923280 PMID:11715018 PMID:20673124 References_end</body> </html> </notes> <label text="MDM2"/> <bbox w="70.0" h="25.0" x="3219.0" y="3302.5"/> </glyph> <glyph class="nucleic acid feature" id="mpk1_mpk1_s899_mpk1_mpk1_sa657" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: growth arrest and DNA-damage-inducible alpha DDIT1 HUGO:GADD45A HGNC:4095 ENTREZ:1647 UNIPROT:P24522 growth arrest and DNA-damage-inducible beta MYD118 HUGO:GADD45B HGNC:4096 ENTREZ:4616 UNIPROT:O75293 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: growth arrest and DNA-damage-inducible alpha DDIT1 HUGO:GADD45A HGNC:4095 ENTREZ:1647 UNIPROT:P24522 GENECARDS:GADD45A KEGG:1647 ATLASONC:GC_GADD45A WIKI:GADD45A growth arrest and DNA-damage-inducible beta MYD118 HUGO:GADD45B HGNC:4096 ENTREZ:4616 UNIPROT:O75293 GENECARDS:GADD45B KEGG:4616 ATLASONC:GC_GADD45B WIKI:GADD45B growth arrest and DNA-damage-inducible gamma HUGO:GADD45G HGNC:4097 ENTREZ:10912 UNIPROT:O95257 GENECARDS:GADD45G KEGG:10912 ATLASONC:GC_GADD45G WIKI:GADD45G Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20025601 PMID:20673124 References_end</body> </html> </notes> <label text="GADD45*"/> <bbox w="70.0" h="25.0" x="3561.0" y="3305.5"/> </glyph> <glyph class="nucleic acid feature" id="mpk1_mpk1_s895_mpk1_mpk1_sa653" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: FBJ murine osteosarcoma viral oncogene homolog "v-fos FBJ murine osteosarcoma viral oncogene homolog" HUGO:FOS HGNC:3796 ENTREZ:2353 UNIPROT:P01100 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end</body> </html> </notes> <label text="FOS"/> <bbox w="70.0" h="25.0" x="1051.0" y="3278.5"/> </glyph> <glyph class="nucleic acid feature" id="mpk1_mpk1_s896_mpk1_mpk1_sa654" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: early growth response 1 HUGO:EGR1 HGNC:3238 ENTREZ:1958 UNIPROT:P18146 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end</body> </html> </notes> <label text="EGR1"/> <bbox w="70.0" h="25.0" x="578.0" y="3328.5"/> </glyph> <glyph class="nucleic acid feature" id="mpk1_mpk1_s897_mpk1_mpk1_sa655" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: dual specificity phosphatase 1 PTPN10 HUGO:DUSP1 HGNC:3064 ENTREZ:1843 UNIPROT:P28562 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end</body> </html> </notes> <label text="DUSP1"/> <bbox w="70.0" h="25.0" x="2328.0" y="3300.5"/> </glyph> <glyph class="nucleic acid feature" id="mpk1_mpk1_s904_mpk1_mpk1_sa662" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: damage-specific DNA binding protein 2 48kDa "damage-specific DNA binding protein 2 (48kD)" HUGO:DDB2 HGNC:2718 ENTREZ:1643 UNIPROT:Q92466 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end</body> </html> </notes> <label text="DDB2"/> <bbox w="70.0" h="25.0" x="3023.0" y="3302.5"/> </glyph> <glyph class="nucleic acid feature" id="mpk1_mpk1_s925_mpk1_mpk1_sa680" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 2A CDKN2 "cyclin-dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4)" MLM HUGO:CDKN2A HGNC:1787 ENTREZ:1029 UNIPROT:P42771 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end</body> </html> </notes> <label text="p14INK4A*"/> <bbox w="70.0" h="25.0" x="2925.0" y="3301.5"/> </glyph> <glyph class="nucleic acid feature" id="mpk1_mpk1_s900_mpk1_mpk1_sa658" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 GENECARDS:CDKN1A REACTOME:87048 KEGG:1026 ATLASONC:CDKN1AID139 WIKI:CDKN1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19440234 PMID:20673124 References_end</body> </html> </notes> <label text="p21CIP1*"/> <bbox w="70.0" h="25.0" x="3310.0" y="3301.5"/> </glyph> <glyph class="nucleic acid feature" id="mpk1_mpk1_s894_mpk1_mpk1_sa652" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: Bcl-2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 GENECARDS:BCL2 REACTOME:50758 KEGG:596 ATLASONC:BCL2ID49 WIKI:BCL2 B-cell CLL/lymphoma 2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18097445 PMID:9735050 References_end</body> </html> Identifiers_begin: Bcl-2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 GENECARDS:BCL2 REACTOME:50758 KEGG:596 ATLASONC:BCL2ID49 WIKI:BCL2 B-cell CLL/lymphoma 2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18097445 PMID:9735050 References_end</body> </html> </notes> <label text="BCL2"/> <bbox w="70.0" h="25.0" x="216.0" y="3274.5"/> </glyph> <glyph class="simple chemical" id="mpk1_mpk1_s488_mpk1_mpk1_sa275" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Ca2+ CAS:N/A PUBCHEM:N/A CHEBI:39124 KEGGCOMPOUND:N/A Identifiers_end References_begin: Calcium liberated from internal stores by IP3 acts on the calcium- and DAG-sensitive RasGRP1 and causes it to translocate to the Golgi. PMID:16488589 References_end</body> </html> </notes> <label text="Ca2+"/> <bbox w="61.0" h="38.0" x="357.44446" y="1917.4445"/> </glyph> <glyph class="phenotype" id="mpk1_mpk1_s910_mpk1_mpk1_sa668" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Apoptosis References_end</body> </html> </notes> <label text="Apoptosis"/> <bbox w="80.0" h="30.0" x="1000.0" y="3458.5"/> </glyph> <glyph class="phenotype" id="mpk1_mpk1_s912_mpk1_mpk1_sa670" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Proliferation References_end</body> </html> </notes> <label text="Proliferation"/> <bbox w="80.0" h="30.0" x="2389.0" y="3460.5"/> </glyph> <glyph class="phenotype" id="mpk1_mpk1_s909_mpk1_mpk1_sa667" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Growth Arrest References_end</body> </html> </notes> <label text="Growth arrest"/> <bbox w="80.0" h="30.0" x="2732.0" y="3460.5"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s491_mpk1_mpk1_sa279" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: CASPASE3 cleaves KSR1 in apoptotic cells. Thus MEK is sequestered in the cytosol and its interaction with Raf and ERK is prevented. PMID:17613518 References_end Identifiers_begin: HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 GENECARDS:CASP3 REACTOME:57022 KEGG:836 ATLASONC:GC_CASP3 WIKI:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 caspase 3 apoptosis-related cysteine peptidase Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: CASPASE3 cleaves KSR1 in apoptotic cells. Thus MEK is sequestered in the cytosol and its interaction with Raf and ERK is prevented. PMID:17613518 PMID:9765224 References_end</body> </html> </notes> <label text="Caspase3*"/> <bbox w="74.0" h="27.0" x="1897.0" y="2382.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s937_mpk1_mpk1_sa691" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ribosomal protein S6 kinase 70kDa polypeptide 1 "ribosomal protein S6 kinase 70kD polypeptide 1" STK14A HUGO:RPS6KB1 HGNC:10436 ENTREZ:6198 UNIPROT:P23443 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: ribosomal protein S6 kinase 70kDa polypeptide 1 "ribosomal protein S6 kinase 70kD polypeptide 1" STK14A HUGO:RPS6KB1 HGNC:10436 ENTREZ:6198 UNIPROT:P23443 GENECARDS:RPS6KB1 REACTOME:57803 KEGG:6198 ATLASONC:GC_RPS6KB1 WIKI:RPS6KB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16286006 PMID:20647036 PMID:11108711 References_end</body> </html> </notes> <label text="p70α*"/> <bbox w="50.0" h="25.0" x="504.0" y="2797.5"/> <glyph class="state variable" id="_f98a4fc2-02db-4d16-bd86-0a95cf1ae4a3"> <state value="" variable="T389"/> <bbox w="30.0" h="10.0" x="539.0" y="2816.034"/> </glyph> <glyph class="state variable" id="_576bb481-ceaa-4602-a4e7-e75ad4653ff8"> <state value="" variable="T229"/> <bbox w="30.0" h="10.0" x="489.0" y="2794.0015"/> </glyph> <glyph class="state variable" id="_6b5ab41b-ca98-4f31-a62c-3f2b74b5b9c5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="499.0" y="2805.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s938_mpk1_mpk1_sa692" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ribosomal protein S6 kinase 70kDa polypeptide 1 "ribosomal protein S6 kinase 70kD polypeptide 1" STK14A HUGO:RPS6KB1 HGNC:10436 ENTREZ:6198 UNIPROT:P23443 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: ribosomal protein S6 kinase 70kDa polypeptide 1 "ribosomal protein S6 kinase 70kD polypeptide 1" STK14A HUGO:RPS6KB1 HGNC:10436 ENTREZ:6198 UNIPROT:P23443 GENECARDS:RPS6KB1 REACTOME:57803 KEGG:6198 ATLASONC:GC_RPS6KB1 WIKI:RPS6KB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16286006 PMID:20647036 PMID:11108711 References_end</body> </html> </notes> <label text="p70α*"/> <bbox w="50.0" h="25.0" x="655.0" y="2812.5"/> <glyph class="state variable" id="_978ba4f6-0066-472c-a636-10ba4bc1bf7c"> <state value="" variable="T389"/> <bbox w="30.0" h="10.0" x="690.0" y="2831.034"/> </glyph> <glyph class="state variable" id="_935d78ca-80b9-4e59-beca-5c7831297e09"> <state value="" variable="T229"/> <bbox w="30.0" h="10.0" x="640.0" y="2809.0015"/> </glyph> <glyph class="state variable" id="_4b1c281a-33d9-4d18-be21-f850b283917a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="647.5" y="2820.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s665_mpk1_mpk1_sa396" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: mitogen-activated protein kinase 11 PRKM11 HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 mitogen-activated protein kinase 12 SAPK3 HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 mitogen-activated protein kinase 13 PRKM13 HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 mitogen-activated protein kinase 14 CSBP1 CSBP2 CSPB1 HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: mitogen-activated protein kinase 11 PRKM11 HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 GENECARDS:MAPK11 REACTOME:59299 KEGG:5600 ATLASONC:GC_MAPK11 WIKI:MAPK11 mitogen-activated protein kinase 12 SAPK3 HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 GENECARDS:MAPK12 REACTOME:69723 KEGG:6300 ATLASONC:MAPK12ID41290ch22q13 WIKI:MAPK12 mitogen-activated protein kinase 13 PRKM13 HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 GENECARDS:MAPK13 REACTOME:59303 KEGG:5603 ATLASONC:MAPK13ID41291ch6p21 WIKI:MAPK13 mitogen-activated protein kinase 14 CSBP1 CSBP2 CSPB1 HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 GENECARDS:MAPK14 REACTOME:405912 KEGG:1432 ATLASONC:MAPK14ID41292ch6p21 WIKI:MAPK14 Mxi2 P38 "P38 MAP kinase" PRKM14 PRKM15 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> Identifiers_begin: mitogen-activated protein kinase 11 PRKM11 HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 GENECARDS:MAPK11 REACTOME:59299 KEGG:5600 ATLASONC:GC_MAPK11 WIKI:MAPK11 mitogen-activated protein kinase 12 SAPK3 HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 GENECARDS:MAPK12 REACTOME:69723 KEGG:6300 ATLASONC:MAPK12ID41290ch22q13 WIKI:MAPK12 mitogen-activated protein kinase 13 PRKM13 HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 GENECARDS:MAPK13 REACTOME:59303 KEGG:5603 ATLASONC:MAPK13ID41291ch6p21 WIKI:MAPK13 mitogen-activated protein kinase 14 CSBP1 CSBP2 CSPB1 HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 GENECARDS:MAPK14 REACTOME:405912 KEGG:1432 ATLASONC:MAPK14ID41292ch6p21 WIKI:MAPK14 Mxi2 P38 "P38 MAP kinase" PRKM14 PRKM15 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="p38*"/> <bbox w="50.0" h="25.0" x="3889.9963" y="2624.0"/> <glyph class="state variable" id="_14cf6d88-89a9-4f66-af55-725c9dcd2373"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3884.9963" y="2636.1318"/> </glyph> <glyph class="state variable" id="_d14adb66-7920-4d40-86a4-fc9e78544940"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3884.9963" y="2626.926"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s675_mpk1_mpk1_sa397" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: mitogen-activated protein kinase 11 PRKM11 HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 mitogen-activated protein kinase 12 SAPK3 HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 mitogen-activated protein kinase 13 PRKM13 HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 mitogen-activated protein kinase 14 CSBP1 CSBP2 CSPB1 HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: mitogen-activated protein kinase 11 PRKM11 HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 GENECARDS:MAPK11 REACTOME:59299 KEGG:5600 ATLASONC:GC_MAPK11 WIKI:MAPK11 mitogen-activated protein kinase 12 SAPK3 HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 GENECARDS:MAPK12 REACTOME:69723 KEGG:6300 ATLASONC:MAPK12ID41290ch22q13 WIKI:MAPK12 mitogen-activated protein kinase 13 PRKM13 HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 GENECARDS:MAPK13 REACTOME:59303 KEGG:5603 ATLASONC:MAPK13ID41291ch6p21 WIKI:MAPK13 mitogen-activated protein kinase 14 CSBP1 CSBP2 CSPB1 HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 GENECARDS:MAPK14 REACTOME:405912 KEGG:1432 ATLASONC:MAPK14ID41292ch6p21 WIKI:MAPK14 Mxi2 P38 "P38 MAP kinase" PRKM14 PRKM15 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> Identifiers_begin: mitogen-activated protein kinase 11 PRKM11 HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 GENECARDS:MAPK11 REACTOME:59299 KEGG:5600 ATLASONC:GC_MAPK11 WIKI:MAPK11 mitogen-activated protein kinase 12 SAPK3 HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 GENECARDS:MAPK12 REACTOME:69723 KEGG:6300 ATLASONC:MAPK12ID41290ch22q13 WIKI:MAPK12 mitogen-activated protein kinase 13 PRKM13 HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 GENECARDS:MAPK13 REACTOME:59303 KEGG:5603 ATLASONC:MAPK13ID41291ch6p21 WIKI:MAPK13 mitogen-activated protein kinase 14 CSBP1 CSBP2 CSPB1 HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 GENECARDS:MAPK14 REACTOME:405912 KEGG:1432 ATLASONC:MAPK14ID41292ch6p21 WIKI:MAPK14 Mxi2 P38 "P38 MAP kinase" PRKM14 PRKM15 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="p38*"/> <bbox w="50.0" h="25.0" x="3570.6328" y="2620.0"/> <glyph class="state variable" id="_044aa9af-882e-46ac-b142-86a97b914bd6"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3563.1328" y="2632.1318"/> </glyph> <glyph class="state variable" id="_e77a2271-1c7f-4a86-a044-3b49c89988ba"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3563.1328" y="2622.926"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s795_mpk1_mpk1_sa550" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: mitogen-activated protein kinase 11 PRKM11 HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 mitogen-activated protein kinase 12 SAPK3 HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 mitogen-activated protein kinase 13 PRKM13 HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 mitogen-activated protein kinase 14 CSBP1 CSBP2 CSPB1 HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: mitogen-activated protein kinase 11 PRKM11 HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 GENECARDS:MAPK11 REACTOME:59299 KEGG:5600 ATLASONC:GC_MAPK11 WIKI:MAPK11 mitogen-activated protein kinase 12 SAPK3 HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 GENECARDS:MAPK12 REACTOME:69723 KEGG:6300 ATLASONC:MAPK12ID41290ch22q13 WIKI:MAPK12 mitogen-activated protein kinase 13 PRKM13 HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 GENECARDS:MAPK13 REACTOME:59303 KEGG:5603 ATLASONC:MAPK13ID41291ch6p21 WIKI:MAPK13 mitogen-activated protein kinase 14 CSBP1 CSBP2 CSPB1 HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 GENECARDS:MAPK14 REACTOME:405912 KEGG:1432 ATLASONC:MAPK14ID41292ch6p21 WIKI:MAPK14 Mxi2 P38 "P38 MAP kinase" PRKM14 PRKM15 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> Identifiers_begin: mitogen-activated protein kinase 11 PRKM11 HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 GENECARDS:MAPK11 REACTOME:59299 KEGG:5600 ATLASONC:GC_MAPK11 WIKI:MAPK11 mitogen-activated protein kinase 12 SAPK3 HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 GENECARDS:MAPK12 REACTOME:69723 KEGG:6300 ATLASONC:MAPK12ID41290ch22q13 WIKI:MAPK12 mitogen-activated protein kinase 13 PRKM13 HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 GENECARDS:MAPK13 REACTOME:59303 KEGG:5603 ATLASONC:MAPK13ID41291ch6p21 WIKI:MAPK13 mitogen-activated protein kinase 14 CSBP1 CSBP2 CSPB1 HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 GENECARDS:MAPK14 REACTOME:405912 KEGG:1432 ATLASONC:MAPK14ID41292ch6p21 WIKI:MAPK14 Mxi2 P38 "P38 MAP kinase" PRKM14 PRKM15 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="p38*"/> <bbox w="50.0" h="25.0" x="2937.7144" y="2913.2856"/> <glyph class="state variable" id="_59f66ccb-b22e-467e-9ac1-2d509c947e51"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2930.2144" y="2925.4175"/> </glyph> <glyph class="state variable" id="_98848bf0-056d-42d3-b9c3-d581ec08f866"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2930.2144" y="2916.2117"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s952_mpk1_mpk1_sa702" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 GENECARDS:CDKN1A REACTOME:87048 KEGG:1026 ATLASONC:CDKN1AID139 WIKI:CDKN1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:P21CIP MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19440234 PMID:12851486 References_end</body> </html> </notes> <label text="p21CIP1*"/> <bbox w="50.0" h="25.0" x="155.0" y="2897.5"/> <glyph class="state variable" id="_c79aa0de-cdee-4df6-917e-23696498002d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="150.0" y="2917.5"/> </glyph> <glyph class="state variable" id="_0c81ba91-2f07-4156-ac9a-002795e511a8"> <state value="" variable="T145"/> <bbox w="30.0" h="10.0" x="140.30783" y="2892.5"/> </glyph> <glyph class="state variable" id="_87302b36-4af6-4840-a676-eec921d75ed9"> <state value="" variable="T146"/> <bbox w="30.0" h="10.0" x="165.01991" y="2892.5"/> </glyph> <glyph class="state variable" id="_fbf60fa6-21ad-440b-8241-e2725172d8bb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="200.0" y="2905.251"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s951_mpk1_mpk1_sa701" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 GENECARDS:CDKN1A REACTOME:87048 KEGG:1026 ATLASONC:CDKN1AID139 WIKI:CDKN1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:P21CIP MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19440234 PMID:12851486 References_end</body> </html> </notes> <label text="p21CIP1*"/> <bbox w="50.0" h="25.0" x="155.0" y="2737.5"/> <glyph class="state variable" id="_c50cc7b2-781c-4c0e-a4aa-81b7674a46d9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="150.0" y="2757.5"/> </glyph> <glyph class="state variable" id="_ae646d80-784e-4f7c-86d0-27303c321305"> <state value="" variable="T145"/> <bbox w="30.0" h="10.0" x="140.30783" y="2732.5"/> </glyph> <glyph class="state variable" id="_382dc0b7-eaa9-4bcb-91a6-2429adbd89c4"> <state value="" variable="T146"/> <bbox w="30.0" h="10.0" x="165.01991" y="2732.5"/> </glyph> <glyph class="state variable" id="_807c690b-a795-48db-b899-1321e6013ff9"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="197.5" y="2745.251"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s926_mpk1_mpk1_sa681" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 2A CDKN2 "cyclin-dependent kinase inhibitor 2A (melanoma p16 inhibits CDK4)" MLM HUGO:CDKN2A HGNC:1787 ENTREZ:1029 UNIPROT:P42771 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end</body> </html> </notes> <label text="p14INK4A*"/> <bbox w="50.0" h="25.0" x="3015.0" y="3137.5"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s673_mpk1_mpk1_sa387" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: thioredoxin HUGO:TXN HGNC:12435 ENTREZ:7295 UNIPROT:P10599 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TNF-dependent production of ROS triggers the dissociation of Trx from ASK1 and the consequently liberalised ASK1 binds to TRAF2. Finally TRAF2 appears to activate ASK1 (by phosphorylation) by enhancing and stabilising the oligomerisation of ASK1. PMID:12655147 References_end</body> </html> </notes> <label text="TXN"/> <bbox w="50.0" h="25.0" x="4112.996" y="1911.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s11_mpk1_mpk1_sa371" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TNF receptor-associated factor 6 E3 ubiquitin protein ligase "TNF receptor-associated factor 6" HUGO:TRAF6 HGNC:12036 ENTREZ:7189 UNIPROT:Q9Y4K3 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Upon recruitment to the IL-1R complex IRAK1 binds TRAF6 forming a MyD88-IRAK1-TRAF6 complex analogous to the TNFR-associated complex of TRADD RIP and TRAF2. PMID:11274345 References_end</body> </html> </notes> <label text="TRAF6"/> <bbox w="50.0" h="25.0" x="3214.9963" y="1840.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s8_mpk1_mpk1_sa368" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TNF receptor-associated factor 2 HUGO:TRAF2 HGNC:12032 ENTREZ:7186 UNIPROT:Q12933 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TRAF proteins are recruited to the TRADD-TNFR1 complex. TRADD couples TNFR1 to TRAF2. TRAF2 directly interacts with TNFR2. ERN1 activation is likely to trigger binding and activation of TRAF2. PMID:11274345 References_end</body> </html> </notes> <label text="TRAF2"/> <bbox w="50.0" h="25.0" x="2592.4963" y="1871.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s10_mpk1_mpk1_sa370" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TNFRSF1A-associated via death domain HUGO:TRADD HGNC:12030 ENTREZ:8717 UNIPROT:Q15628 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins. PMID:11274345 References_end</body> </html> </notes> <label text="TRADD"/> <bbox w="56.0" h="25.0" x="2341.4963" y="1823.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s786_mpk1_mpk1_sa543" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 References_end Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end</body> </html> Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end</body> </html> Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end</body> </html> </notes> <label text="p53*"/> <bbox w="50.0" h="25.0" x="3341.0" y="2900.0"/> <glyph class="state variable" id="_efbe2d84-2f6a-4bdb-a638-397205b4986e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3386.0" y="2920.0"/> </glyph> <glyph class="state variable" id="_32322593-6619-4ac0-a27c-f615b0ff27e0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3336.0" y="2895.0"/> </glyph> <glyph class="state variable" id="_4ccc0d83-154b-4adf-80d5-6c76210fb770"> <state value="" variable="S46"/> <bbox w="25.0" h="10.0" x="3378.5" y="2895.1343"/> </glyph> <glyph class="state variable" id="_cfa45c17-7b54-47c2-ab2a-f7d182d058a3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3336.0" y="2907.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s787_mpk1_mpk1_sa544" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 References_end Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end</body> </html> Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end</body> </html> Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end</body> </html> </notes> <label text="p53*"/> <bbox w="50.0" h="25.0" x="3345.7144" y="3079.8572"/> <glyph class="state variable" id="_cf84ef29-457b-4a2e-bf82-e2f72413e721"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3390.7144" y="3099.8572"/> </glyph> <glyph class="state variable" id="_7c4359d8-da9d-45d0-883a-9847033071c1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3340.7144" y="3074.8572"/> </glyph> <glyph class="state variable" id="_4aab98ed-c596-4aec-8f1e-ccbae85144eb"> <state value="" variable="S46"/> <bbox w="25.0" h="10.0" x="3383.2144" y="3074.9915"/> </glyph> <glyph class="state variable" id="_47cf8177-dd77-4f17-8dac-43ea724f483c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3338.2144" y="3087.3572"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s22_mpk1_mpk1_sa374" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tumor necrosis factor receptor superfamily member 1B TNFR2 HUGO:TNFRSF1B HGNC:11917 ENTREZ:7133 UNIPROT:P20333 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins (TRAF2). PMID:11274345 References_end</body> </html> </notes> <label text="TNFRSF1B"/> <bbox w="70.0" h="25.0" x="2636.9963" y="1316.0"/> <glyph class="unit of information" id="_9bfe0063-fb49-4efb-8cd7-f20f2f5886f5"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2649.4963" y="1311.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s9_mpk1_mpk1_sa369" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tumor necrosis factor receptor superfamily member 1A TNFR1 HUGO:TNFRSF1A HGNC:11916 ENTREZ:7132 UNIPROT:P19438 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins. PMID:11274345 References_end</body> </html> </notes> <label text="TNFRSF1A"/> <bbox w="70.0" h="25.0" x="2325.4963" y="1315.0"/> <glyph class="unit of information" id="_0f5c3931-2f42-41d3-af4d-dfc22b8bc709"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2337.9963" y="1310.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s577_mpk1_mpk1_sa342" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 transcription factor 7-like 1 (T-cell specific HMG-box) TCF3 HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 transcription factor 7-like 2 (T-cell specific HMG-box) TCF4 HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end</body> </html> Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end</body> </html> </notes> <label text="LEF_TCF*"/> <bbox w="65.0" h="25.0" x="191.0" y="2977.0"/> <glyph class="state variable" id="_fb9260a5-d478-459f-9588-a8a23ee095ee"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="251.0" y="2972.5488"/> </glyph> <glyph class="state variable" id="_1a270029-9ef0-4449-8f5c-0b9e595a6159"> <state value="" variable="S40"/> <bbox w="25.0" h="10.0" x="243.5" y="2994.8838"/> </glyph> <glyph class="state variable" id="_55eb14ea-df68-4062-8e74-5c8cd3409234"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="251.0" y="2984.5"/> </glyph> <glyph class="state variable" id="_35f62584-b6ef-4640-bce8-d8c34c2a6bce"> <state value="" variable="S166"/> <bbox w="30.0" h="10.0" x="176.40018" y="2972.0"/> </glyph> <glyph class="state variable" id="_6e1773f9-72e6-44cf-8af6-550b0b881708"> <state value="" variable="T155"/> <bbox w="30.0" h="10.0" x="176.0" y="2996.8264"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s634_mpk1_mpk1_sa391" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TAO kinase 1 HUGO:TAOK1 HGNC:29259 ENTREZ:57551 UNIPROT:Q7L7X3 TAO kinase 2 HUGO:TAOK2 HGNC:16835 ENTREZ:9344 UNIPROT:Q9UL54 TAO kinase 3 HUGO:TAOK3 HGNC:18133 ENTREZ:51347 UNIPROT:Q9H2K8 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TAO kinases are novel MAP3Ks that specifically regulate P38s. Ataxia telangiectasia mutated (ATM) is activated in response to DNA damage and directly phosphorylates TAOK. PMID:11274345 PMID:18855897 References_end</body> </html> </notes> <label text="TAOK*"/> <bbox w="63.0" h="24.0" x="4038.5" y="2228.0"/> <glyph class="state variable" id="_793fb783-4579-4152-a610-a010cbc8777b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4033.5" y="2235.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s635_mpk1_mpk1_sa530" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TAO kinase 1 HUGO:TAOK1 HGNC:29259 ENTREZ:57551 UNIPROT:Q7L7X3 TAO kinase 2 HUGO:TAOK2 HGNC:16835 ENTREZ:9344 UNIPROT:Q9UL54 TAO kinase 3 HUGO:TAOK3 HGNC:18133 ENTREZ:51347 UNIPROT:Q9H2K8 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TAO kinases are novel MAP3Ks that specifically regulate P38s. Ataxia telangiectasia mutated (ATM) is activated in response to DNA damage and directly phosphorylates TAOK. PMID:11274345 PMID:18855897 References_end</body> </html> </notes> <label text="TAOK*"/> <bbox w="63.0" h="24.0" x="4051.5" y="2347.5"/> <glyph class="state variable" id="_41078317-0195-4162-b62f-d54d2d024acc"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4044.0" y="2354.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s666_mpk1_mpk1_sa379" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 1 MAP3K7IP1 "mitogen-activated protein kinase kinase kinase 7 interacting protein 1" HUGO:TAB1 HGNC:18157 ENTREZ:10454 UNIPROT:Q15750 TGF-beta activated kinase 1/MAP3K7 binding protein 2 MAP3K7IP2 "mitogen-activated protein kinase kinase kinase 7 interacting protein 2" HUGO:TAB2 HGNC:17075 ENTREZ:23118 UNIPROT:Q9NYJ8 TGF-beta activated kinase 1/MAP3K7 binding protein 3 MAP3K7IP3 "mitogen-activated protein kinase kinase kinase 7 interacting protein 3" HUGO:TAB3 HGNC:30681 ENTREZ:257397 UNIPROT:Q8N5C8 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TAK1 is the only MAP3K that requires the adapter proteins TAB123 for its activation. PMID:20060931 References_end</body> </html> </notes> <label text="TAB*"/> <bbox w="50.0" h="25.0" x="3455.9963" y="1845.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s921_mpk1_mpk1_sa677" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: SMAD family member 4 "MAD mothers against decapentaplegic homolog 4 (Drosophila)" MADH4 "SMAD mothers against DPP homolog 4 (Drosophila)" HUGO:SMAD4 HGNC:6770 ENTREZ:4089 UNIPROT:Q13485 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TGF-?? exerts its biological effects by binding to a cell surface receptor complex composed of type I (TbRI) and type II (TbRII) receptor serine/threonine kinases. Upon ligand binding TbRII phosphorylates and activates TbRI which subsequently phosphorylates the cytoplasmic Smad2 and Smad3 proteins. Phosphorylated Smad proteins form stable complexes with a common partner Smad4. The activated Smad2/4 and Smad3/4 complexes translocate into the nucleus where the Smad oligomers induce transcriptional activation (or inhibition) of specific target genes. PMID:21614932 References_end</body> </html> </notes> <label text="SMAD4"/> <bbox w="50.0" h="25.0" x="4155.0" y="2727.5"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s914_mpk1_mpk1_sa672" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: SMAD family member 3 "MAD mothers against decapentaplegic homolog 3 (Drosophila)" MADH3 "SMAD mothers against DPP homolog 3 (Drosophila)" HUGO:SMAD3 HGNC:6769 ENTREZ:4088 UNIPROT:P84022 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TGF-?? exerts its biological effects by binding to a cell surface receptor complex composed of type I (TbRI) and type II (TbRII) receptor serine/threonine kinases. Upon ligand binding TbRII phosphorylates and activates TbRI which subsequently phosphorylates the cytoplasmic Smad2 and Smad3 proteins. Phosphorylated Smad proteins form stable complexes with a common partner Smad4. The activated Smad2/4 and Smad3/4 complexes translocate into the nucleus where the Smad oligomers induce transcriptional activation (or inhibition) of specific target genes. PMID:21614932 References_end</body> </html> </notes> <label text="SMAD3"/> <bbox w="50.0" h="25.0" x="4105.0" y="2637.5"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s913_mpk1_mpk1_sa671" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: SMAD family member 2 "MAD mothers against decapentaplegic homolog 2 (Drosophila)" MADH2 "SMAD mothers against DPP homolog 2 (Drosophila)" HUGO:SMAD2 HGNC:6768 ENTREZ:4087 UNIPROT:Q15796 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TGF-?? exerts its biological effects by binding to a cell surface receptor complex composed of type I (TbRI) and type II (TbRII) receptor serine/threonine kinases. Upon ligand binding TbRII phosphorylates and activates TbRI which subsequently phosphorylates the cytoplasmic Smad2 and Smad3 proteins. Phosphorylated Smad proteins form stable complexes with a common partner Smad4. The activated Smad2/4 and Smad3/4 complexes translocate into the nucleus where the Smad oligomers induce transcriptional activation (or inhibition) of specific target genes. PMID:21614932 References_end Identifiers_begin: SMAD family member 2 "MAD mothers against decapentaplegic homolog 2 (Drosophila)" MADH2 "SMAD mothers against DPP homolog 2 (Drosophila)" HUGO:SMAD2 HGNC:6768 ENTREZ:4087 UNIPROT:Q15796 GENECARDS:SMAD2 REACTOME:405890 KEGG:4087 ATLASONC:SMAD2ID370 WIKI:SMAD2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: TGF-?? exerts its biological effects by binding to a cell surface receptor complex composed of type I (TbRI) and type II (TbRII) receptor serine/threonine kinases. Upon ligand binding TbRII phosphorylates and activates TbRI which subsequently phosphorylates the cytoplasmic Smad2 and Smad3 proteins. Phosphorylated Smad proteins form stable complexes with a common partner Smad4. The activated Smad2/4 and Smad3/4 complexes translocate into the nucleus where the Smad oligomers induce transcriptional activation (or inhibition) of specific target genes. PMID:21614932 References_end</body> </html> </notes> <label text="SMAD2"/> <bbox w="50.0" h="25.0" x="4025.0" y="2637.5"/> <glyph class="state variable" id="_a6fbf8d7-e2c4-4091-9d6e-f7315b52afaf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4070.0" y="2632.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s230_mpk1_mpk1_sa144" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: soc-2 suppressor of clear homolog (C. elegans) "soc-2 (suppressor of clear C.elegans) homolog" HUGO:SHOC2 HGNC:15454 ENTREZ:8036 UNIPROT:Q9UQ13 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Sur-8 contributes to the Raf activation process by promoting the dephosphorylation of the inhibitory N-terminal 14-3-3 binding site on Raf. PMID:17496910 References_end</body> </html> </notes> <label text="SUR-8*"/> <bbox w="50.0" h="25.0" x="1690.0" y="2206.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s959_mpk1_mpk1_sa707" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: signal transducer and activator of transcription 1 91kDa "signal transducer and activator of transcription 1 91kD" HUGO:STAT1 HGNC:11362 ENTREZ:6772 UNIPROT:P42224 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end</body> </html> </notes> <label text="STAT1"/> <bbox w="50.0" h="25.0" x="155.0" y="3087.5"/> <glyph class="state variable" id="_b82a95e5-df40-4225-8c80-9533e75869f3"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="147.5" y="3095.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s958_mpk1_mpk1_sa706" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: signal transducer and activator of transcription 1 91kDa "signal transducer and activator of transcription 1 91kD" HUGO:STAT1 HGNC:11362 ENTREZ:6772 UNIPROT:P42224 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end</body> </html> </notes> <label text="STAT1"/> <bbox w="50.0" h="25.0" x="264.0" y="3145.5"/> <glyph class="state variable" id="_aebc3253-7590-4f22-9d15-1bb9881ffc4d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="259.0" y="3153.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s274_mpk1_mpk1_sa171" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) SRC1 "v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog" HUGO:SRC HGNC:11283 ENTREZ:6714 UNIPROT:P12931 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Many activated RTKs induce the Src-dependent activation of PLCG PMID:17496910 References_end Identifiers_begin: v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) SRC1 "v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog" HUGO:SRC HGNC:11283 ENTREZ:6714 UNIPROT:P12931 GENECARDS:SRC REACTOME:402877 KEGG:6714 ATLASONC:SRCID448ch20q11 WIKI:SRC Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Many activated RTKs induce the Src-dependent activation of PLCG PMID:17496910 References_end</body> </html> </notes> <label text="SRC"/> <bbox w="50.0" h="25.0" x="211.0" y="1888.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s962_mpk1_mpk1_sa710" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: sprouty homolog 2 (Drosophila) "sprouty (Drosophila) homolog 2" HUGO:SPRY2 HGNC:11270 ENTREZ:10253 UNIPROT:O43597 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end</body> </html> </notes> <label text="SPRY2"/> <bbox w="50.0" h="25.0" x="2675.0" y="2577.5"/> <glyph class="state variable" id="_90464559-1d93-41fa-a310-cbd366255e27"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2670.0" y="2585.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s963_mpk1_mpk1_sa711" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: sprouty homolog 2 (Drosophila) "sprouty (Drosophila) homolog 2" HUGO:SPRY2 HGNC:11270 ENTREZ:10253 UNIPROT:O43597 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end</body> </html> </notes> <label text="SPRY2"/> <bbox w="50.0" h="25.0" x="2625.0" y="2657.5"/> <glyph class="state variable" id="_38a0c4eb-c2fe-44da-83d6-b43b192be6cc"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2617.5" y="2665.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s976_mpk1_mpk1_sa719" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: sprouty homolog 1 antagonist of FGF signaling (Drosophila) "sprouty (Drosophila) homolog 1 (antagonist of FGF signaling)" HUGO:SPRY1 HGNC:11269 ENTREZ:10252 UNIPROT:O43609 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end</body> </html> </notes> <label text="SPRY1"/> <bbox w="50.0" h="25.0" x="2560.0" y="2574.0"/> <glyph class="state variable" id="_391c1635-e628-40aa-bef7-aa023a5983cf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2555.0" y="2581.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s977_mpk1_mpk1_sa720" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: sprouty homolog 1 antagonist of FGF signaling (Drosophila) "sprouty (Drosophila) homolog 1 (antagonist of FGF signaling)" HUGO:SPRY1 HGNC:11269 ENTREZ:10252 UNIPROT:O43609 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end</body> </html> </notes> <label text="SPRY1"/> <bbox w="50.0" h="25.0" x="2532.5" y="2655.0"/> <glyph class="state variable" id="_6b014a05-dc4c-4354-9202-571b9b864efe"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2525.0" y="2662.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s974_mpk1_mpk1_sa717" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 References_end Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 GENECARDS:SOS1 REACTOME:64848 KEGG:6654 ATLASONC:GC_SOS1 WIKI:SOS1 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 GENECARDS:SOS2 REACTOME:64850 ATLASONC:GC_SOS2 WIKI:SOS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="SOS*"/> <bbox w="50.0" h="25.0" x="489.5" y="2024.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s609_mpk1_mpk1_sa214" compartmentRef="mpk1_mpk1_c5_mpk1_mpk1_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: interleukin 17 receptor D HUGO:IL17RD HGNC:17616 ENTREZ:54756 UNIPROT:Q8NFM7 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Sef1 which is a putative transmembrane protein of the Golgi apparatus seems to be a scaffold protein that recruits ERK1/2 and MEK1/2 to its vicinity and probably allows their activation by Golgi-localised Ras proteins. Unlike many other scaffolds ERK1/2 do not dissociate from Sef1 upon stimulation and therefore nuclear translocation of the Sef1 anchored fraction of ERK1/2 molecules is blocked. PMID:19565474 PMID:19565474 References_end</body> </html> </notes> <label text="SEF*"/> <bbox w="50.0" h="25.0" x="472.0" y="2299.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s384_mpk1_mpk1_sa22" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> </notes> <label text="RTK*"/> <bbox w="50.0" h="25.0" x="665.0" y="1317.5"/> <glyph class="state variable" id="_83dd0659-7b6c-4ae2-a1f4-ba8b0de7b97f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="710.0" y="1330.1776"/> </glyph> <glyph class="state variable" id="_312226cb-7a1a-4a8c-9c8b-1dad5fe5b497"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="710.0" y="1330.1776"/> </glyph> <glyph class="state variable" id="_3b92f245-fdca-4ab0-ab54-01a1ad0cb93f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="710.0" y="1325.0"/> </glyph> <glyph class="unit of information" id="_cac82e9f-08fa-4597-b4cc-1ad29fae2815"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="667.5" y="1312.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s516_mpk1_mpk1_sa295" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: ribosomal protein S6 kinase 90kDa polypeptide 1 "ribosomal protein S6 kinase 90kD polypeptide 1" HUGO:RPS6KA1 HGNC:10430 ENTREZ:6195 UNIPROT:Q15418 ribosomal protein S6 kinase 90kDa polypeptide 2 "ribosomal protein S6 kinase 90kD polypeptide 2" HUGO:RPS6KA2 HGNC:10431 ENTREZ:6196 UNIPROT:Q15349 ribosomal protein S6 kinase 90kDa polypeptide 3 CLS "Coffin-Lowry syndrome" "mental retardation X-linked 19" MRX19 "ribosomal protein S6 kinase 90kD polypeptide 3" HUGO:RPS6KA3 HGNC:10432 ENTREZ:6197 UNIPROT:P51812 ribosomal protein S6 kinase 90kDa polypeptide 6 "ribosomal protein S6 kinase 90kD polypeptide 6" HUGO:RPS6KA6 HGNC:10435 ENTREZ:27330 UNIPROT:Q9UK32 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RSK2 is a well known ERK substrate in the cytoplasm. RSKs are exclusively activated by ERK. Activated RSK can be found in both nuclear and cytoplasmic compartments. PMID:15239952 PMID:15187187 References_end Identifiers_begin: ribosomal protein S6 kinase 90kDa polypeptide 1 "ribosomal protein S6 kinase 90kD polypeptide 1" HUGO:RPS6KA1 HGNC:10430 ENTREZ:6195 UNIPROT:Q15418 GENECARDS:RPS6KA1 REACTOME:57795 KEGG:6195 ATLASONC:RPS6KA1ID43477ch1p36 WIKI:RPS6KA1 ribosomal protein S6 kinase 90kDa polypeptide 2 "ribosomal protein S6 kinase 90kD polypeptide 2" HUGO:RPS6KA2 HGNC:10431 ENTREZ:6196 UNIPROT:Q15349 GENECARDS:RPS6KA2 REACTOME:57797 KEGG:6196 ATLASONC:GC_RPS6KA2 WIKI:RPS6KA2 ribosomal protein S6 kinase 90kDa polypeptide 3 CLS "Coffin-Lowry syndrome" "mental retardation X-linked 19" MRX19 "ribosomal protein S6 kinase 90kD polypeptide 3" HUGO:RPS6KA3 HGNC:10432 ENTREZ:6197 UNIPROT:P51812 GENECARDS:RPS6KA3 REACTOME:57799 KEGG:6197 ATLASONC:GC_RPS6KA3 WIKI:RPS6KA3 ribosomal protein S6 kinase 90kDa polypeptide 6 "ribosomal protein S6 kinase 90kD polypeptide 6" HUGO:RPS6KA6 HGNC:10435 ENTREZ:27330 UNIPROT:Q9UK32 GENECARDS:RPS6KA6 REACTOME:57801 KEGG:27330 ATLASONC:GC_RPS6KA6 WIKI:RPS6KA6 ribosomal protein S6 kinase 90kDa polypeptide 4 HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 GENECARDS:RPS6KA4 REACTOME:93591 KEGG:8986 ATLASONC:GC_RPS6KA4 WIKI:RPS6KA4 HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 GENECARDS:RPS6KA4 REACTOME:93591 KEGG:8986 ATLASONC:GC_RPS6KA4 WIKI:RPS6KA4 HUGO:PIM1 HGNC:8986 ENTREZ:5292 UNIPROT:P11309 GENECARDS:PIM1 KEGG:9361 ATLASONC:PIM1ID261 WIKI:PIM1 ribosomal protein S6 kinase, 90kDa, polypeptide 5 HUGO:RPS6KA5 HGNC:10434 ENTREZ:9252 UNIPROT:O75582 GENECARDS:RPS6KA5 REACTOME:93593 KEGG:9252 ATLASONC:GC_RPS6KA5 WIKI:RPS6KA5 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RSK2 is a well known ERK substrate in the cytoplasm. RSKs are exclusively activated by ERK. Activated RSK can be found in both nuclear and cytoplasmic compartments. PMID:15239952 PMID:15187187 PMID:16286006 PMID:21233202 References_end</body> </html> Identifiers_begin: ribosomal protein S6 kinase 90kDa polypeptide 1 "ribosomal protein S6 kinase 90kD polypeptide 1" HUGO:RPS6KA1 HGNC:10430 ENTREZ:6195 UNIPROT:Q15418 GENECARDS:RPS6KA1 REACTOME:57795 KEGG:6195 ATLASONC:RPS6KA1ID43477ch1p36 WIKI:RPS6KA1 ribosomal protein S6 kinase 90kDa polypeptide 2 "ribosomal protein S6 kinase 90kD polypeptide 2" HUGO:RPS6KA2 HGNC:10431 ENTREZ:6196 UNIPROT:Q15349 GENECARDS:RPS6KA2 REACTOME:57797 KEGG:6196 ATLASONC:GC_RPS6KA2 WIKI:RPS6KA2 ribosomal protein S6 kinase 90kDa polypeptide 3 CLS "Coffin-Lowry syndrome" "mental retardation X-linked 19" MRX19 "ribosomal protein S6 kinase 90kD polypeptide 3" HUGO:RPS6KA3 HGNC:10432 ENTREZ:6197 UNIPROT:P51812 GENECARDS:RPS6KA3 REACTOME:57799 KEGG:6197 ATLASONC:GC_RPS6KA3 WIKI:RPS6KA3 ribosomal protein S6 kinase 90kDa polypeptide 6 "ribosomal protein S6 kinase 90kD polypeptide 6" HUGO:RPS6KA6 HGNC:10435 ENTREZ:27330 UNIPROT:Q9UK32 GENECARDS:RPS6KA6 REACTOME:57801 KEGG:27330 ATLASONC:GC_RPS6KA6 WIKI:RPS6KA6 ribosomal protein S6 kinase 90kDa polypeptide 4 HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 GENECARDS:RPS6KA4 REACTOME:93591 KEGG:8986 ATLASONC:GC_RPS6KA4 WIKI:RPS6KA4 HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 GENECARDS:RPS6KA4 REACTOME:93591 KEGG:8986 ATLASONC:GC_RPS6KA4 WIKI:RPS6KA4 HUGO:PIM1 HGNC:8986 ENTREZ:5292 UNIPROT:P11309 GENECARDS:PIM1 KEGG:9361 ATLASONC:PIM1ID261 WIKI:PIM1 ribosomal protein S6 kinase, 90kDa, polypeptide 5 HUGO:RPS6KA5 HGNC:10434 ENTREZ:9252 UNIPROT:O75582 GENECARDS:RPS6KA5 REACTOME:93593 KEGG:9252 ATLASONC:GC_RPS6KA5 WIKI:RPS6KA5 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RSK2 is a well known ERK substrate in the cytoplasm. RSKs are exclusively activated by ERK. Activated RSK can be found in both nuclear and cytoplasmic compartments. PMID:15239952 PMID:15187187 PMID:16286006 PMID:21233202 References_end</body> </html> </notes> <label text="RSK*"/> <bbox w="50.0" h="25.0" x="1823.0" y="2630.0"/> <glyph class="state variable" id="_2ef1e3ac-6905-4cee-a0c1-fbd8682dc841"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1818.0" y="2637.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s558_mpk1_mpk1_sa325" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: ribosomal protein S6 kinase 90kDa polypeptide 1 "ribosomal protein S6 kinase 90kD polypeptide 1" HUGO:RPS6KA1 HGNC:10430 ENTREZ:6195 UNIPROT:Q15418 ribosomal protein S6 kinase 90kDa polypeptide 2 "ribosomal protein S6 kinase 90kD polypeptide 2" HUGO:RPS6KA2 HGNC:10431 ENTREZ:6196 UNIPROT:Q15349 ribosomal protein S6 kinase 90kDa polypeptide 3 CLS "Coffin-Lowry syndrome" "mental retardation X-linked 19" MRX19 "ribosomal protein S6 kinase 90kD polypeptide 3" HUGO:RPS6KA3 HGNC:10432 ENTREZ:6197 UNIPROT:P51812 ribosomal protein S6 kinase 90kDa polypeptide 6 "ribosomal protein S6 kinase 90kD polypeptide 6" HUGO:RPS6KA6 HGNC:10435 ENTREZ:27330 UNIPROT:Q9UK32 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RSK2 is a well known ERK substrate in the cytoplasm. RSKs are exclusively activated by ERK. Activated RSK can be found in both nuclear and cytoplasmic compartments. PMID:15239952 PMID:15187187 References_end Identifiers_begin: ribosomal protein S6 kinase 90kDa polypeptide 1 "ribosomal protein S6 kinase 90kD polypeptide 1" HUGO:RPS6KA1 HGNC:10430 ENTREZ:6195 UNIPROT:Q15418 GENECARDS:RPS6KA1 REACTOME:57795 KEGG:6195 ATLASONC:RPS6KA1ID43477ch1p36 WIKI:RPS6KA1 ribosomal protein S6 kinase 90kDa polypeptide 2 "ribosomal protein S6 kinase 90kD polypeptide 2" HUGO:RPS6KA2 HGNC:10431 ENTREZ:6196 UNIPROT:Q15349 GENECARDS:RPS6KA2 REACTOME:57797 KEGG:6196 ATLASONC:GC_RPS6KA2 WIKI:RPS6KA2 ribosomal protein S6 kinase 90kDa polypeptide 3 CLS "Coffin-Lowry syndrome" "mental retardation X-linked 19" MRX19 "ribosomal protein S6 kinase 90kD polypeptide 3" HUGO:RPS6KA3 HGNC:10432 ENTREZ:6197 UNIPROT:P51812 GENECARDS:RPS6KA3 REACTOME:57799 KEGG:6197 ATLASONC:GC_RPS6KA3 WIKI:RPS6KA3 ribosomal protein S6 kinase 90kDa polypeptide 6 "ribosomal protein S6 kinase 90kD polypeptide 6" HUGO:RPS6KA6 HGNC:10435 ENTREZ:27330 UNIPROT:Q9UK32 GENECARDS:RPS6KA6 REACTOME:57801 KEGG:27330 ATLASONC:GC_RPS6KA6 WIKI:RPS6KA6 ribosomal protein S6 kinase 90kDa polypeptide 4 HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 GENECARDS:RPS6KA4 REACTOME:93591 KEGG:8986 ATLASONC:GC_RPS6KA4 WIKI:RPS6KA4 HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 GENECARDS:RPS6KA4 REACTOME:93591 KEGG:8986 ATLASONC:GC_RPS6KA4 WIKI:RPS6KA4 HUGO:PIM1 HGNC:8986 ENTREZ:5292 UNIPROT:P11309 GENECARDS:PIM1 KEGG:9361 ATLASONC:PIM1ID261 WIKI:PIM1 ribosomal protein S6 kinase, 90kDa, polypeptide 5 HUGO:RPS6KA5 HGNC:10434 ENTREZ:9252 UNIPROT:O75582 GENECARDS:RPS6KA5 REACTOME:93593 KEGG:9252 ATLASONC:GC_RPS6KA5 WIKI:RPS6KA5 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RSK2 is a well known ERK substrate in the cytoplasm. RSKs are exclusively activated by ERK. Activated RSK can be found in both nuclear and cytoplasmic compartments. PMID:15239952 PMID:15187187 PMID:16286006 PMID:21233202 References_end</body> </html> Identifiers_begin: ribosomal protein S6 kinase 90kDa polypeptide 1 "ribosomal protein S6 kinase 90kD polypeptide 1" HUGO:RPS6KA1 HGNC:10430 ENTREZ:6195 UNIPROT:Q15418 GENECARDS:RPS6KA1 REACTOME:57795 KEGG:6195 ATLASONC:RPS6KA1ID43477ch1p36 WIKI:RPS6KA1 ribosomal protein S6 kinase 90kDa polypeptide 2 "ribosomal protein S6 kinase 90kD polypeptide 2" HUGO:RPS6KA2 HGNC:10431 ENTREZ:6196 UNIPROT:Q15349 GENECARDS:RPS6KA2 REACTOME:57797 KEGG:6196 ATLASONC:GC_RPS6KA2 WIKI:RPS6KA2 ribosomal protein S6 kinase 90kDa polypeptide 3 CLS "Coffin-Lowry syndrome" "mental retardation X-linked 19" MRX19 "ribosomal protein S6 kinase 90kD polypeptide 3" HUGO:RPS6KA3 HGNC:10432 ENTREZ:6197 UNIPROT:P51812 GENECARDS:RPS6KA3 REACTOME:57799 KEGG:6197 ATLASONC:GC_RPS6KA3 WIKI:RPS6KA3 ribosomal protein S6 kinase 90kDa polypeptide 6 "ribosomal protein S6 kinase 90kD polypeptide 6" HUGO:RPS6KA6 HGNC:10435 ENTREZ:27330 UNIPROT:Q9UK32 GENECARDS:RPS6KA6 REACTOME:57801 KEGG:27330 ATLASONC:GC_RPS6KA6 WIKI:RPS6KA6 ribosomal protein S6 kinase 90kDa polypeptide 4 HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 GENECARDS:RPS6KA4 REACTOME:93591 KEGG:8986 ATLASONC:GC_RPS6KA4 WIKI:RPS6KA4 HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 GENECARDS:RPS6KA4 REACTOME:93591 KEGG:8986 ATLASONC:GC_RPS6KA4 WIKI:RPS6KA4 HUGO:PIM1 HGNC:8986 ENTREZ:5292 UNIPROT:P11309 GENECARDS:PIM1 KEGG:9361 ATLASONC:PIM1ID261 WIKI:PIM1 ribosomal protein S6 kinase, 90kDa, polypeptide 5 HUGO:RPS6KA5 HGNC:10434 ENTREZ:9252 UNIPROT:O75582 GENECARDS:RPS6KA5 REACTOME:93593 KEGG:9252 ATLASONC:GC_RPS6KA5 WIKI:RPS6KA5 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RSK2 is a well known ERK substrate in the cytoplasm. RSKs are exclusively activated by ERK. Activated RSK can be found in both nuclear and cytoplasmic compartments. PMID:15239952 PMID:15187187 PMID:16286006 PMID:21233202 References_end</body> </html> </notes> <label text="RSK*"/> <bbox w="50.0" h="25.0" x="1278.1666" y="2873.3335"/> <glyph class="state variable" id="_dc61df4f-b827-45b3-97d4-0a2be2e59fac"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1270.6666" y="2880.8335"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s604_mpk1_mpk1_sa326" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: ribosomal protein S6 kinase 90kDa polypeptide 1 "ribosomal protein S6 kinase 90kD polypeptide 1" HUGO:RPS6KA1 HGNC:10430 ENTREZ:6195 UNIPROT:Q15418 ribosomal protein S6 kinase 90kDa polypeptide 2 "ribosomal protein S6 kinase 90kD polypeptide 2" HUGO:RPS6KA2 HGNC:10431 ENTREZ:6196 UNIPROT:Q15349 ribosomal protein S6 kinase 90kDa polypeptide 3 CLS "Coffin-Lowry syndrome" "mental retardation X-linked 19" MRX19 "ribosomal protein S6 kinase 90kD polypeptide 3" HUGO:RPS6KA3 HGNC:10432 ENTREZ:6197 UNIPROT:P51812 ribosomal protein S6 kinase 90kDa polypeptide 6 "ribosomal protein S6 kinase 90kD polypeptide 6" HUGO:RPS6KA6 HGNC:10435 ENTREZ:27330 UNIPROT:Q9UK32 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RSK2 is a well known ERK substrate in the cytoplasm. RSKs are exclusively activated by ERK. Activated RSK can be found in both nuclear and cytoplasmic compartments. PMID:15239952 PMID:15187187 References_end Identifiers_begin: ribosomal protein S6 kinase 90kDa polypeptide 1 "ribosomal protein S6 kinase 90kD polypeptide 1" HUGO:RPS6KA1 HGNC:10430 ENTREZ:6195 UNIPROT:Q15418 GENECARDS:RPS6KA1 REACTOME:57795 KEGG:6195 ATLASONC:RPS6KA1ID43477ch1p36 WIKI:RPS6KA1 ribosomal protein S6 kinase 90kDa polypeptide 2 "ribosomal protein S6 kinase 90kD polypeptide 2" HUGO:RPS6KA2 HGNC:10431 ENTREZ:6196 UNIPROT:Q15349 GENECARDS:RPS6KA2 REACTOME:57797 KEGG:6196 ATLASONC:GC_RPS6KA2 WIKI:RPS6KA2 ribosomal protein S6 kinase 90kDa polypeptide 3 CLS "Coffin-Lowry syndrome" "mental retardation X-linked 19" MRX19 "ribosomal protein S6 kinase 90kD polypeptide 3" HUGO:RPS6KA3 HGNC:10432 ENTREZ:6197 UNIPROT:P51812 GENECARDS:RPS6KA3 REACTOME:57799 KEGG:6197 ATLASONC:GC_RPS6KA3 WIKI:RPS6KA3 ribosomal protein S6 kinase 90kDa polypeptide 6 "ribosomal protein S6 kinase 90kD polypeptide 6" HUGO:RPS6KA6 HGNC:10435 ENTREZ:27330 UNIPROT:Q9UK32 GENECARDS:RPS6KA6 REACTOME:57801 KEGG:27330 ATLASONC:GC_RPS6KA6 WIKI:RPS6KA6 ribosomal protein S6 kinase 90kDa polypeptide 4 HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 GENECARDS:RPS6KA4 REACTOME:93591 KEGG:8986 ATLASONC:GC_RPS6KA4 WIKI:RPS6KA4 HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 GENECARDS:RPS6KA4 REACTOME:93591 KEGG:8986 ATLASONC:GC_RPS6KA4 WIKI:RPS6KA4 HUGO:PIM1 HGNC:8986 ENTREZ:5292 UNIPROT:P11309 GENECARDS:PIM1 KEGG:9361 ATLASONC:PIM1ID261 WIKI:PIM1 ribosomal protein S6 kinase, 90kDa, polypeptide 5 HUGO:RPS6KA5 HGNC:10434 ENTREZ:9252 UNIPROT:O75582 GENECARDS:RPS6KA5 REACTOME:93593 KEGG:9252 ATLASONC:GC_RPS6KA5 WIKI:RPS6KA5 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RSK2 is a well known ERK substrate in the cytoplasm. RSKs are exclusively activated by ERK. Activated RSK can be found in both nuclear and cytoplasmic compartments. PMID:15239952 PMID:15187187 PMID:16286006 PMID:21233202 References_end</body> </html> Identifiers_begin: ribosomal protein S6 kinase 90kDa polypeptide 1 "ribosomal protein S6 kinase 90kD polypeptide 1" HUGO:RPS6KA1 HGNC:10430 ENTREZ:6195 UNIPROT:Q15418 GENECARDS:RPS6KA1 REACTOME:57795 KEGG:6195 ATLASONC:RPS6KA1ID43477ch1p36 WIKI:RPS6KA1 ribosomal protein S6 kinase 90kDa polypeptide 2 "ribosomal protein S6 kinase 90kD polypeptide 2" HUGO:RPS6KA2 HGNC:10431 ENTREZ:6196 UNIPROT:Q15349 GENECARDS:RPS6KA2 REACTOME:57797 KEGG:6196 ATLASONC:GC_RPS6KA2 WIKI:RPS6KA2 ribosomal protein S6 kinase 90kDa polypeptide 3 CLS "Coffin-Lowry syndrome" "mental retardation X-linked 19" MRX19 "ribosomal protein S6 kinase 90kD polypeptide 3" HUGO:RPS6KA3 HGNC:10432 ENTREZ:6197 UNIPROT:P51812 GENECARDS:RPS6KA3 REACTOME:57799 KEGG:6197 ATLASONC:GC_RPS6KA3 WIKI:RPS6KA3 ribosomal protein S6 kinase 90kDa polypeptide 6 "ribosomal protein S6 kinase 90kD polypeptide 6" HUGO:RPS6KA6 HGNC:10435 ENTREZ:27330 UNIPROT:Q9UK32 GENECARDS:RPS6KA6 REACTOME:57801 KEGG:27330 ATLASONC:GC_RPS6KA6 WIKI:RPS6KA6 ribosomal protein S6 kinase 90kDa polypeptide 4 HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 GENECARDS:RPS6KA4 REACTOME:93591 KEGG:8986 ATLASONC:GC_RPS6KA4 WIKI:RPS6KA4 HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 GENECARDS:RPS6KA4 REACTOME:93591 KEGG:8986 ATLASONC:GC_RPS6KA4 WIKI:RPS6KA4 HUGO:PIM1 HGNC:8986 ENTREZ:5292 UNIPROT:P11309 GENECARDS:PIM1 KEGG:9361 ATLASONC:PIM1ID261 WIKI:PIM1 ribosomal protein S6 kinase, 90kDa, polypeptide 5 HUGO:RPS6KA5 HGNC:10434 ENTREZ:9252 UNIPROT:O75582 GENECARDS:RPS6KA5 REACTOME:93593 KEGG:9252 ATLASONC:GC_RPS6KA5 WIKI:RPS6KA5 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RSK2 is a well known ERK substrate in the cytoplasm. RSKs are exclusively activated by ERK. Activated RSK can be found in both nuclear and cytoplasmic compartments. PMID:15239952 PMID:15187187 PMID:16286006 PMID:21233202 References_end</body> </html> </notes> <label text="RSK*"/> <bbox w="50.0" h="25.0" x="1822.5" y="2708.6665"/> <glyph class="state variable" id="_64d47a7f-2e79-4230-a7d8-046fddbe270b"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1815.0" y="2716.1665"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s13_mpk1_mpk1_sa372" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: receptor (TNFRSF)-interacting serine-threonine kinase 1 HUGO:RIPK1 HGNC:10019 ENTREZ:8737 UNIPROT:Q13546 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TNF treatment is thought to result in the formation of a TRADD-RIP-TRAF2 complex at the membrane. PMID:11274345 References_end</body> </html> </notes> <label text="RIPK1"/> <bbox w="50.0" h="25.0" x="2492.9963" y="1844.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s257_mpk1_mpk1_sa158" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAS guanyl releasing protein 1 (calcium and DAG-regulated) HUGO:RASGRP1 HGNC:9878 ENTREZ:10125 UNIPROT:O95267 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RasGRP1 specifically activates H-Ras in the Golgi. It is localised in the cytosol in quiescent cells. After PMA stimulus at first it moves to the PM and then shifts towards other subcellular compartments like the Golgi apparatus. RasGRP1 is a C1-domain containing protein that is activated by DAG and Ca2+ in a manner analogous to members of the PKC family. PMID:12782630 PMID:17496910 Activation of PKC: http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Second_messengers.html References_end</body> </html> </notes> <label text="RASGRP1"/> <bbox w="64.0" h="25.0" x="327.0" y="1852.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s302_mpk1_mpk1_sa186" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAS P21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Calcium activates the Ras GAP CAPRI (RASA4) that translocates to the PM and downregulates any Ras that is activated on this compartment by the exchange factor SOS. PMID:16488589 References_end</body> </html> </notes> <label text="RASA4"/> <bbox w="50.0" h="25.0" x="525.0" y="1907.5"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s303_mpk1_mpk1_sa188" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RAS P21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Calcium activates the Ras GAP CAPRI (RASA4) that translocates to the PM and downregulates any Ras that is activated on this compartment by the exchange factor SOS. PMID:16488589 References_end</body> </html> </notes> <label text="RASA4"/> <bbox w="50.0" h="25.0" x="525.0" y="1727.5"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s25_mpk1_mpk1_sa28" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> </notes> <label text="RAS*"/> <bbox w="50.0" h="25.0" x="725.0" y="1734.0"/> <glyph class="state variable" id="_d15d22ce-d12d-4334-96e5-0e987f052561"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="720.0" y="1741.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s358_mpk1_mpk1_sa240" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: v-raf-1 murine leukemia viral oncogene homolog 1 HUGO:RAF1 HGNC:9829 ENTREZ:5894 UNIPROT:P04049 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Active KRas (on late endosomes) recruits Raf1 (C-Raf) to elicit a MODULE:MAPK signalling pathway. Raf1 MEK1/2 and ERK1/2 may act in the outer side of the Golgi apparatus and attenuate proliferation. PMID:19289794 PMID:19565474 References_end Identifiers_begin: v-raf-1 murine leukemia viral oncogene homolog 1 HUGO:RAF1 HGNC:9829 ENTREZ:5894 UNIPROT:P04049 GENECARDS:RAF1 REACTOME:58255 KEGG:5894 ATLASONC:RAF1ID42032ch3p25 WIKI:RAF1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Active KRas (on late endosomes) recruits Raf1 (C-Raf) to elicit a MODULE:MAPK signalling pathway. Raf1 MEK1/2 and ERK1/2 may act in the outer side of the Golgi apparatus and attenuate proliferation. PMID:19289794 PMID:19565474 References_end</body> </html> </notes> <label text="RAF1"/> <bbox w="66.0" h="26.0" x="777.0" y="2189.0"/> <glyph class="state variable" id="_b9a50226-af31-4a2c-b601-676c409301ff"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="772.0" y="2197.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s573_mpk1_mpk1_sa338" compartmentRef="mpk1_mpk1_c7_mpk1_mpk1_ca7"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: v-raf-1 murine leukemia viral oncogene homolog 1 HUGO:RAF1 HGNC:9829 ENTREZ:5894 UNIPROT:P04049 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Active KRas (on late endosomes) recruits Raf1 (C-Raf) to elicit a MODULE:MAPK signalling pathway. Raf1 MEK1/2 and ERK1/2 may act in the outer side of the Golgi apparatus and attenuate proliferation. PMID:19289794 PMID:19565474 References_end Identifiers_begin: v-raf-1 murine leukemia viral oncogene homolog 1 HUGO:RAF1 HGNC:9829 ENTREZ:5894 UNIPROT:P04049 GENECARDS:RAF1 REACTOME:58255 KEGG:5894 ATLASONC:RAF1ID42032ch3p25 WIKI:RAF1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Active KRas (on late endosomes) recruits Raf1 (C-Raf) to elicit a MODULE:MAPK signalling pathway. Raf1 MEK1/2 and ERK1/2 may act in the outer side of the Golgi apparatus and attenuate proliferation. PMID:19289794 PMID:19565474 References_end</body> </html> </notes> <label text="RAF1"/> <bbox w="66.0" h="26.0" x="1347.0" y="1927.0"/> <glyph class="state variable" id="_cdda8794-733b-41aa-844d-b5394333735d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1339.5" y="1935.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s965_mpk1_mpk1_sa712" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: v-raf-1 murine leukemia viral oncogene homolog 1 HUGO:RAF1 HGNC:9829 ENTREZ:5894 UNIPROT:P04049 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Active KRas (on late endosomes) recruits Raf1 (C-Raf) to elicit a MODULE:MAPK signalling pathway. Raf1 MEK1/2 and ERK1/2 may act in the outer side of the Golgi apparatus and attenuate proliferation. PMID:19289794 PMID:19565474 References_end Identifiers_begin: v-raf-1 murine leukemia viral oncogene homolog 1 HUGO:RAF1 HGNC:9829 ENTREZ:5894 UNIPROT:P04049 GENECARDS:RAF1 REACTOME:58255 KEGG:5894 ATLASONC:RAF1ID42032ch3p25 WIKI:RAF1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Active KRas (on late endosomes) recruits Raf1 (C-Raf) to elicit a MODULE:MAPK signalling pathway. Raf1 MEK1/2 and ERK1/2 may act in the outer side of the Golgi apparatus and attenuate proliferation. PMID:19289794 PMID:19565474 References_end</body> </html> </notes> <label text="RAF1"/> <bbox w="66.0" h="26.0" x="1915.5" y="2209.0"/> <glyph class="state variable" id="_17c34166-3d95-4e3f-8c80-0ebfa7f5bb90"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1908.0" y="2217.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s618_mpk1_mpk1_sa389" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <bbox w="60.0" h="25.0" x="990.0" y="1577.5"/> <glyph class="state variable" id="_e1027fc0-78df-4b83-9fe7-7a85d8ebf8f6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="985.0" y="1585.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s800_mpk1_mpk1_sa555" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 References_end Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> </notes> <label text="PP2A_C*"/> <bbox w="50.0" h="25.0" x="2084.0" y="2400.0"/> <glyph class="state variable" id="_619ddfc8-60aa-4c6b-bf45-7840e056fa67"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="2076.5" y="2407.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s801_mpk1_mpk1_sa556" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 References_end Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> </notes> <label text="PP2A_C*"/> <bbox w="68.0" h="26.0" x="2181.5" y="2346.6665"/> <glyph class="state variable" id="_78c49375-7080-4576-8d98-6f02b91d0005"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2176.5" y="2354.6665"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s596_mpk1_mpk1_sa360" compartmentRef="mpk1_mpk1_c7_mpk1_mpk1_ca7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: peptidylprolyl isomerase D "peptidylprolyl isomerase D (cyclophilin D)" HUGO:PPID HGNC:9257 ENTREZ:5481 UNIPROT:Q08752 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Mitochondrial chaperone cyclophilin D (CYPD) enhances PTP opening. PMID:20080742 References_end</body> </html> </notes> <label text="PPID"/> <bbox w="62.0" h="25.0" x="1188.5" y="2003.0"/> <glyph class="state variable" id="_6e1a7b7a-5bfc-4cf2-ae6b-5d7984ee231e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1183.5" y="2010.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s598_mpk1_mpk1_sa358" compartmentRef="mpk1_mpk1_c7_mpk1_mpk1_ca7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: peptidylprolyl isomerase D "peptidylprolyl isomerase D (cyclophilin D)" HUGO:PPID HGNC:9257 ENTREZ:5481 UNIPROT:Q08752 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Mitochondrial chaperone cyclophilin D (CYPD) enhances PTP opening. PMID:20080742 References_end</body> </html> </notes> <label text="PPID"/> <bbox w="62.0" h="25.0" x="1178.0" y="2079.5"/> <glyph class="state variable" id="_fa2f1b3b-e57a-4d30-b44e-63fb51db3ab8"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1170.5" y="2087.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s275_mpk1_mpk1_sa166" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: phospholipase C gamma 1 "phospholipase C gamma 1 (formerly subtype 148)" PLC1 HUGO:PLCG1 HGNC:9065 ENTREZ:5335 UNIPROT:P19174 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: In response to Src-dependent activation of PLCG1 RasGRP1 translocated to the Golgi where it activated Ras. PMID:12845332 References_end</body> </html> </notes> <label text="PLCG1"/> <bbox w="50.0" h="25.0" x="255.0" y="1833.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s522_mpk1_mpk1_sa301" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: phospholipase A2 group IVA (cytosolic calcium-dependent) PLA2G4 HUGO:PLA2G4A HGNC:9035 ENTREZ:5321 UNIPROT:P47712 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Results supported the notion that KSR1 coupled activated ERK1/2 selectively to its substrate cPLA2 (PLA2G4A) in response to signals generated at lipid rafts. PMID:19114553 References_end</body> </html> </notes> <label text="PLA2G4A"/> <bbox w="85.0" h="26.0" x="1962.0" y="2300.0"/> <glyph class="state variable" id="_7153fedf-c043-4e7f-946c-30e91c089c1b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1957.0" y="2308.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s523_mpk1_mpk1_sa302" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: phospholipase A2 group IVA (cytosolic calcium-dependent) PLA2G4 HUGO:PLA2G4A HGNC:9035 ENTREZ:5321 UNIPROT:P47712 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Results supported the notion that KSR1 coupled activated ERK1/2 selectively to its substrate cPLA2 (PLA2G4A) in response to signals generated at lipid rafts. PMID:19114553 References_end</body> </html> </notes> <label text="PLA2G4A"/> <bbox w="85.0" h="26.0" x="2165.6667" y="2307.3335"/> <glyph class="state variable" id="_c6bb7d7a-d1f3-460b-9c3c-b7eb056f8a96"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2158.1667" y="2315.3335"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s945_mpk1_mpk1_sa698" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polycystic kidney disease 1 (autosomal dominant) HUGO:PKD1 HGNC:9008 ENTREZ:5310 UNIPROT:P98161 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end</body> </html> </notes> <label text="PKD1"/> <bbox w="50.0" h="25.0" x="958.0" y="2077.5"/> <glyph class="state variable" id="_a9d31c2a-857e-4180-ba90-558eb2104887"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="950.5" y="2085.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s947_mpk1_mpk1_sa697" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polycystic kidney disease 1 (autosomal dominant) HUGO:PKD1 HGNC:9008 ENTREZ:5310 UNIPROT:P98161 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end</body> </html> </notes> <label text="PKD1"/> <bbox w="50.0" h="25.0" x="818.0" y="2082.5"/> <glyph class="state variable" id="_054ef07a-8097-4f18-99ca-01bb1c6e008c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="813.0" y="2090.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s932_mpk1_mpk1_sa687" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: protein kinase C alpha PKCA HUGO:PRKCA HGNC:9393 ENTREZ:5578 UNIPROT:P17252 protein kinase C beta PKCB PRKCB1 PRKCB2 "protein kinase C beta 1" HUGO:PRKCB HGNC:9395 ENTREZ:5579 UNIPROT:P05771 protein kinase C gamma PKCG SCA14 HUGO:PRKCG HGNC:9402 ENTREZ:5582 UNIPROT:P05129 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity. PMID:15567848 References_end Identifiers_begin: protein kinase C alpha PKCA HUGO:PRKCA HGNC:9393 ENTREZ:5578 UNIPROT:P17252 GENECARDS:PRKCA REACTOME:58197 KEGG:5578 ATLASONC:GC_PRKCA WIKI:PRKCA protein kinase C beta PKCB PRKCB1 PRKCB2 "protein kinase C beta 1" HUGO:PRKCB HGNC:9395 ENTREZ:5579 UNIPROT:P05771 GENECARDS:PRKCB REACTOME:58199 KEGG:5579 ATLASONC:GC_PRKCB WIKI:PRKCB protein kinase C gamma PKCG SCA14 HUGO:PRKCG HGNC:9402 ENTREZ:5582 UNIPROT:P05129 GENECARDS:PRKCG REACTOME:58205 KEGG:5582 ATLASONC:GC_PRKCG WIKI:PRKCG protein kinase C, delta HUGO:PRKCD HGNC:9399 ENTREZ:5580 UNIPROT:Q05655 GENECARDS:PRKCD REACTOME:58201 KEGG:5580 ATLASONC:PRKCDID42901ch3p21 WIKI:PRKCD protein kinase C, epsilon HUGO:PRKCE HGNC:9401 ENTREZ:5581 UNIPROT:Q02156 GENECARDS:PRKCE REACTOME:58203 KEGG:5581 ATLASONC:GC_PRKCE WIKI:PRKCE protein kinase C, eta HUGO:PRKCH HGNC:9403 ENTREZ:5583 UNIPROT:P24723 GENECARDS:PRKCH REACTOME:58209 KEGG:5583 ATLASONC:GC_PRKCH WIKI:PRKCH protein kinase C, iota HUGO:PRKCI HGNC:9404 ENTREZ:5584 UNIPROT:P41743 GENECARDS:PRKCI REACTOME:58207 KEGG:5584 ATLASONC:PRKCIID41857ch3q26 WIKI:PRKCI protein kinase C, theta HUGO:PRKCQ HGNC:9410 ENTREZ:5588 UNIPROT:Q04759 GENECARDS:PRKCQ REACTOME:58217 KEGG:5588 ATLASONC:GC_PRKCQ WIKI:PRKCQ Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity. PMID:15567848 PMID:11313945 PMID:11940581 Only PKC alpha and delta PMID:21386996 References_end</body> </html> Identifiers_begin: protein kinase C alpha PKCA HUGO:PRKCA HGNC:9393 ENTREZ:5578 UNIPROT:P17252 GENECARDS:PRKCA REACTOME:58197 KEGG:5578 ATLASONC:GC_PRKCA WIKI:PRKCA protein kinase C beta PKCB PRKCB1 PRKCB2 "protein kinase C beta 1" HUGO:PRKCB HGNC:9395 ENTREZ:5579 UNIPROT:P05771 GENECARDS:PRKCB REACTOME:58199 KEGG:5579 ATLASONC:GC_PRKCB WIKI:PRKCB protein kinase C gamma PKCG SCA14 HUGO:PRKCG HGNC:9402 ENTREZ:5582 UNIPROT:P05129 GENECARDS:PRKCG REACTOME:58205 KEGG:5582 ATLASONC:GC_PRKCG WIKI:PRKCG protein kinase C, delta HUGO:PRKCD HGNC:9399 ENTREZ:5580 UNIPROT:Q05655 GENECARDS:PRKCD REACTOME:58201 KEGG:5580 ATLASONC:PRKCDID42901ch3p21 WIKI:PRKCD protein kinase C, epsilon HUGO:PRKCE HGNC:9401 ENTREZ:5581 UNIPROT:Q02156 GENECARDS:PRKCE REACTOME:58203 KEGG:5581 ATLASONC:GC_PRKCE WIKI:PRKCE protein kinase C, eta HUGO:PRKCH HGNC:9403 ENTREZ:5583 UNIPROT:P24723 GENECARDS:PRKCH REACTOME:58209 KEGG:5583 ATLASONC:GC_PRKCH WIKI:PRKCH protein kinase C, iota HUGO:PRKCI HGNC:9404 ENTREZ:5584 UNIPROT:P41743 GENECARDS:PRKCI REACTOME:58207 KEGG:5584 ATLASONC:PRKCIID41857ch3q26 WIKI:PRKCI protein kinase C, theta HUGO:PRKCQ HGNC:9410 ENTREZ:5588 UNIPROT:Q04759 GENECARDS:PRKCQ REACTOME:58217 KEGG:5588 ATLASONC:GC_PRKCQ WIKI:PRKCQ Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity. PMID:15567848 PMID:11313945 PMID:11940581 Only PKC alpha and delta PMID:21386996 References_end</body> </html> </notes> <label text="PKC*"/> <bbox w="50.0" h="25.0" x="595.0" y="1807.5"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s942_mpk1_mpk1_sa695" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: phosphoinositide-3-kinase, catalytic, alpha polypeptide HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 GENECARDS:PIK3CA REACTOME:61074 KEGG:5290 ATLASONC:PIK3CAID415ch3q26 WIKI:PIK3CA phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, delta polypeptide HUGO:PIK3CD HGNC:8977 ENTREZ:5293 UNIPROT:O00329 GENECARDS:PIK3CD REACTOME:61078 KEGG:5293 ATLASONC:PIK3CDID46261ch1p36 WIKI:PIK3CD phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 References_end</body> </html> Identifiers_begin: phosphoinositide-3-kinase, catalytic, alpha polypeptide HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 GENECARDS:PIK3CA REACTOME:61074 KEGG:5290 ATLASONC:PIK3CAID415ch3q26 WIKI:PIK3CA phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, delta polypeptide HUGO:PIK3CD HGNC:8977 ENTREZ:5293 UNIPROT:O00329 GENECARDS:PIK3CD REACTOME:61078 KEGG:5293 ATLASONC:PIK3CDID46261ch1p36 WIKI:PIK3CD phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 References_end</body> </html> </notes> <label text="p110*"/> <bbox w="50.0" h="25.0" x="1030.0" y="1876.5"/> <glyph class="state variable" id="_fdd12291-31b2-4dfb-914f-e6113aa4f43d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1025.0" y="1884.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s944_mpk1_mpk1_sa696" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: phosphoinositide-3-kinase, catalytic, alpha polypeptide HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 GENECARDS:PIK3CA REACTOME:61074 KEGG:5290 ATLASONC:PIK3CAID415ch3q26 WIKI:PIK3CA phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, delta polypeptide HUGO:PIK3CD HGNC:8977 ENTREZ:5293 UNIPROT:O00329 GENECARDS:PIK3CD REACTOME:61078 KEGG:5293 ATLASONC:PIK3CDID46261ch1p36 WIKI:PIK3CD phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 References_end</body> </html> Identifiers_begin: phosphoinositide-3-kinase, catalytic, alpha polypeptide HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 GENECARDS:PIK3CA REACTOME:61074 KEGG:5290 ATLASONC:PIK3CAID415ch3q26 WIKI:PIK3CA phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, delta polypeptide HUGO:PIK3CD HGNC:8977 ENTREZ:5293 UNIPROT:O00329 GENECARDS:PIK3CD REACTOME:61078 KEGG:5293 ATLASONC:PIK3CDID46261ch1p36 WIKI:PIK3CD phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 References_end</body> </html> </notes> <label text="p110*"/> <bbox w="50.0" h="25.0" x="937.0" y="2005.5"/> <glyph class="state variable" id="_8c84317c-426c-4319-a112-e13d836e5b9c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="929.5" y="2013.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s700_mpk1_mpk1_sa424" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="61.0" h="24.0" x="2611.163" y="2754.1665"/> <glyph class="state variable" id="_b078f572-2623-4dfc-8909-01fddae414ad"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2667.163" y="2766.137"/> </glyph> <glyph class="state variable" id="_0ab2456d-47e6-4078-a893-17be9fa6d28f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2667.163" y="2773.1665"/> </glyph> <glyph class="state variable" id="_27a3d24a-4ad0-4d04-9b88-8878e71d322f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2649.2966" y="2773.1665"/> </glyph> <glyph class="state variable" id="_4b26a23d-900f-4203-b0eb-cd11835df073"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2606.163" y="2749.1665"/> </glyph> <glyph class="state variable" id="_d7dc5213-54f4-4548-b1b1-3e9761631dca"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2624.0295" y="2749.1665"/> </glyph> <glyph class="state variable" id="_be52d56b-0d83-45de-9b0b-df9096aefc4b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2636.663" y="2749.1665"/> </glyph> <glyph class="state variable" id="_f5de6b0c-1d90-460a-8f5f-92fc7b9ee8b8"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2603.663" y="2761.1665"/> </glyph> <glyph class="state variable" id="_d9f12f99-e0a6-4ce6-bbc4-438cc31c92db"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2649.2966" y="2749.1665"/> </glyph> <glyph class="state variable" id="_168b0498-96e4-4434-bc1c-90f1f10e931c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2667.163" y="2749.1665"/> </glyph> <glyph class="state variable" id="_58eb13ac-b2ef-459c-a244-8774304b4c6e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2667.163" y="2756.196"/> </glyph> <glyph class="state variable" id="_5cd14bb3-d306-4d80-9ff9-896fb4d78f08"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2667.163" y="2761.1665"/> </glyph> <glyph class="state variable" id="_182301a6-1360-42bb-9dbf-458303a5bbd1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2606.163" y="2749.1665"/> </glyph> <glyph class="state variable" id="_5a097db4-e34b-4020-b4b9-6559f4b9b2cb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2606.163" y="2756.196"/> </glyph> <glyph class="state variable" id="_78d6660e-5fab-441e-9cea-38b68402523d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2606.163" y="2766.137"/> </glyph> <glyph class="state variable" id="_f19a335c-e421-4768-94d9-5dc13aec84d4"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="2606.5762" y="2773.1665"/> </glyph> <glyph class="state variable" id="_ede6fced-5902-4ff4-96b5-ca414081df6d"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="2621.979" y="2773.1665"/> </glyph> <glyph class="state variable" id="_bccaf518-a879-484b-ac21-901693f50de9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2636.663" y="2773.1665"/> </glyph> <glyph class="state variable" id="_d286c1d8-357c-4a0b-b0cf-4e338e9a3c6f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2624.0295" y="2773.1665"/> </glyph> <glyph class="state variable" id="_0a9049ca-be58-48c0-ab00-e0d69a775cd0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2606.163" y="2773.1665"/> </glyph> <glyph class="state variable" id="_34823cd7-ba0a-4f4f-a576-5994f90a5baf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2606.163" y="2761.1665"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s780_mpk1_mpk1_sa425" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="61.0" h="24.0" x="2005.1631" y="2923.0"/> <glyph class="state variable" id="_66b705d4-e701-421c-acc1-cbfca0a83dce"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2061.163" y="2934.9705"/> </glyph> <glyph class="state variable" id="_467a0b40-0521-44d6-95fa-137e8e1e1597"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2061.163" y="2942.0"/> </glyph> <glyph class="state variable" id="_e31c158f-ea4f-407e-8a18-db49019c3d16"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2043.2966" y="2942.0"/> </glyph> <glyph class="state variable" id="_2e5efcab-0e19-4d30-8f87-a107d540a76e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2000.1631" y="2918.0"/> </glyph> <glyph class="state variable" id="_c9e867c6-7eb0-4593-98ef-d1b4f149ba02"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2018.0295" y="2918.0"/> </glyph> <glyph class="state variable" id="_02c62c74-39e4-4dc6-bbef-9dab5d5f343b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2030.6631" y="2918.0"/> </glyph> <glyph class="state variable" id="_1892121c-b7ae-40dd-9431-19939d86dfc9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2000.1631" y="2930.0"/> </glyph> <glyph class="state variable" id="_6a58e8cf-89cc-40b9-96e7-1be9a01d562b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2043.2966" y="2918.0"/> </glyph> <glyph class="state variable" id="_74ad8670-a87e-411d-b8b1-77851e5f2205"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2061.163" y="2918.0"/> </glyph> <glyph class="state variable" id="_59250631-943b-4d9b-a479-8bcc42d6ff3b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2061.163" y="2925.0295"/> </glyph> <glyph class="state variable" id="_f65829c3-65cb-4fbb-9f16-5fb3916c3e9d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2061.163" y="2930.0"/> </glyph> <glyph class="state variable" id="_69a334cd-2fcb-4d80-9aec-1044781a8e50"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2000.1631" y="2918.0"/> </glyph> <glyph class="state variable" id="_e8ba9af8-90dc-4ae7-987d-fe68287b83bd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2000.1631" y="2925.0295"/> </glyph> <glyph class="state variable" id="_ae072354-afc0-42f0-82d4-970334c5adf3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2000.1631" y="2934.9705"/> </glyph> <glyph class="state variable" id="_57160157-55dd-4902-8ca1-de373675e2da"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="2000.5762" y="2942.0"/> </glyph> <glyph class="state variable" id="_c67033d1-1bcb-408b-8833-4b45557bce40"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="2015.9789" y="2942.0"/> </glyph> <glyph class="state variable" id="_4ce1412d-c7a6-488c-82a0-f73ee871e5e5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2030.6631" y="2942.0"/> </glyph> <glyph class="state variable" id="_50e4d9d0-70dc-4fdc-950e-860ea00f08ee"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2018.0295" y="2942.0"/> </glyph> <glyph class="state variable" id="_bfe97e38-136b-48bf-b1bb-65fb69d9fa72"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2000.1631" y="2942.0"/> </glyph> <glyph class="state variable" id="_4e721795-497c-48cc-ad1f-ca50bda26d90"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2000.1631" y="2930.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s781_mpk1_mpk1_sa423" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="61.0" h="24.0" x="2466.9963" y="2753.0"/> <glyph class="state variable" id="_59d9f6ad-1278-4f5d-9e88-a93b02afb073"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2522.9963" y="2764.9705"/> </glyph> <glyph class="state variable" id="_9783c957-a6e6-4b8b-b9f3-187bfa151027"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2522.9963" y="2772.0"/> </glyph> <glyph class="state variable" id="_ec2c911b-58e8-42a6-ac65-900fb7d70ec3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2505.13" y="2772.0"/> </glyph> <glyph class="state variable" id="_b157c640-aba8-4b02-a859-90e71643f16c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2461.9963" y="2748.0"/> </glyph> <glyph class="state variable" id="_28eae522-bcba-4835-a5ee-07b6971eeb96"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2479.8628" y="2748.0"/> </glyph> <glyph class="state variable" id="_5c365ae8-fcd9-4c43-953e-61a24193da23"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2492.4963" y="2748.0"/> </glyph> <glyph class="state variable" id="_e2e90580-576e-42be-9e6e-b7e6f2f6fb56"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2461.9963" y="2760.0"/> </glyph> <glyph class="state variable" id="_8a9d6830-2780-45b6-86b7-032e6537e0cf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2505.13" y="2748.0"/> </glyph> <glyph class="state variable" id="_c7537903-a4ec-4cff-9ac5-b27fa4aa8295"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2522.9963" y="2748.0"/> </glyph> <glyph class="state variable" id="_2d50c0fc-ca55-4b2d-9c4f-ba88114b9419"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2522.9963" y="2755.0295"/> </glyph> <glyph class="state variable" id="_386e4c12-670b-407d-abf2-398b589040d9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2522.9963" y="2760.0"/> </glyph> <glyph class="state variable" id="_62655db5-5862-4c63-b5e7-1c3421e21151"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2461.9963" y="2748.0"/> </glyph> <glyph class="state variable" id="_51c6d6a7-f1a9-4f51-a1f8-7e743865c3c6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2461.9963" y="2755.0295"/> </glyph> <glyph class="state variable" id="_8527c1be-f44d-463c-bb96-6631840bdc96"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2461.9963" y="2764.9705"/> </glyph> <glyph class="state variable" id="_a3b8922c-5c16-40b7-9fad-4410c80c0c56"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="2462.4094" y="2772.0"/> </glyph> <glyph class="state variable" id="_9d63b66d-e3d5-417c-a7b7-bc8f6b45682c"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="2477.8123" y="2772.0"/> </glyph> <glyph class="state variable" id="_cbe59043-cbd5-47fb-86bf-d17a00bd4b82"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2492.4963" y="2772.0"/> </glyph> <glyph class="state variable" id="_7d9717c3-5edd-43c0-be21-5996c35a20f9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2479.8628" y="2772.0"/> </glyph> <glyph class="state variable" id="_d6eb7056-81d2-449a-a45f-24e846fede93"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2461.9963" y="2772.0"/> </glyph> <glyph class="state variable" id="_ec00185a-5246-45fa-87b1-27780f3e1286"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2461.9963" y="2760.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s30_mpk1_mpk1_sa376" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: myeloid differentiation primary response 88 "myeloid differentiation primary response gene (88)" HUGO:MYD88 HGNC:7562 ENTREZ:4615 UNIPROT:Q99836 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: The IL-1R/IL-1RAcP heterodimer recruits the death domain adapter protein MyD88. PMID:11274345 References_end</body> </html> </notes> <label text="MYD88"/> <bbox w="63.0" h="24.0" x="2939.9963" y="1852.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s696_mpk1_mpk1_sa420" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) "v-myc avian myelocytomatosis viral oncogene homolog" HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: C-MYC is a key regulator of cell proliferation differentiaton and apoptosis. The biological functions of C-MYC are thought to depend in part on the polypeptide binding partners with which it interacts. PMID:11274345 References_end Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) "v-myc avian myelocytomatosis viral oncogene homolog" HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 GENECARDS:MYC REACTOME:59773 KEGG:4609 ATLASONC:MYCID27 WIKI:MYC Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: C-MYC is a key regulator of cell proliferation differentiaton and apoptosis. The biological functions of C-MYC are thought to depend in part on the polypeptide binding partners with which it interacts. PMID:11274345 References_end</body> </html> </notes> <label text="MYC"/> <bbox w="50.0" h="25.0" x="3526.163" y="2950.3335"/> <glyph class="state variable" id="_7c21dff9-f506-4b82-b2a9-8cf9aeda1768"> <state value="" variable="T58"/> <bbox w="25.0" h="10.0" x="3513.663" y="2970.16"/> </glyph> <glyph class="state variable" id="_1a81966a-5d5f-42bb-9e98-8ad25be83d17"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="3563.663" y="2945.4678"/> </glyph> <glyph class="state variable" id="_a1b6f634-8c3e-4e5e-98b4-34be2614eff9"> <state value="" variable="S62"/> <bbox w="25.0" h="10.0" x="3513.971" y="2945.3335"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s928_mpk1_mpk1_sa683" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>HUGO:MST1 MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:23792360 Both in vitro and in vivo evidence has revealed that MSP???RON signalling is important for the invasive growth of different types of cancers. Identifiers_begin: macrophage stimulating 1 (hepatocyte growth factor-like) D3F15S2 DNF15S2 HGFL HUGO:MST1 HGNC:7380 ENTREZ:4485 UNIPROT:P26927 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end</body> </html> </notes> <label text="MST1"/> <bbox w="50.0" h="25.0" x="2515.0" y="2947.5"/> <glyph class="state variable" id="_3eb7c6b0-0f4d-4451-84bd-6f663e0f9e10"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2510.0" y="2955.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s929_mpk1_mpk1_sa684" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>HUGO:MST1 MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:23792360 Both in vitro and in vivo evidence has revealed that MSP???RON signalling is important for the invasive growth of different types of cancers. Identifiers_begin: macrophage stimulating 1 (hepatocyte growth factor-like) D3F15S2 DNF15S2 HGFL HUGO:MST1 HGNC:7380 ENTREZ:4485 UNIPROT:P26927 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end</body> </html> </notes> <label text="MST1"/> <bbox w="50.0" h="25.0" x="2515.0" y="3077.5"/> <glyph class="state variable" id="_d4d398fd-9741-4d9e-b091-2c6f6630a3d8"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2507.5" y="3085.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s560_mpk1_mpk1_sa327" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ribosomal protein S6 kinase 90kDa polypeptide 4 "ribosomal protein S6 kinase 90kD polypeptide 4" HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 ribosomal protein S6 kinase 90kDa polypeptide 5 "ribosomal protein S6 kinase 90kD polypeptide 5" HUGO:RPS6KA5 HGNC:10434 ENTREZ:9252 UNIPROT:O75582 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MSK1 and MSK2 are potently activated (by phosphorylation) in vivo by ERK1/2 and P38 but not JNK. They are localised in the nucleus of quiescent and activated cells which suggest that they may preferentially phosphorylate nuclear substrates. PMID:15187187 References_end</body> </html> </notes> <label text="MSK*"/> <bbox w="50.0" h="25.0" x="494.0" y="2871.0"/> <glyph class="state variable" id="_69ab4864-1785-404c-a259-19c053400b7b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="489.0" y="2878.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s561_mpk1_mpk1_sa328" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ribosomal protein S6 kinase 90kDa polypeptide 4 "ribosomal protein S6 kinase 90kD polypeptide 4" HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 ribosomal protein S6 kinase 90kDa polypeptide 5 "ribosomal protein S6 kinase 90kD polypeptide 5" HUGO:RPS6KA5 HGNC:10434 ENTREZ:9252 UNIPROT:O75582 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MSK1 and MSK2 are potently activated (by phosphorylation) in vivo by ERK1/2 and P38 but not JNK. They are localised in the nucleus of quiescent and activated cells which suggest that they may preferentially phosphorylate nuclear substrates. PMID:15187187 References_end</body> </html> </notes> <label text="MSK*"/> <bbox w="50.0" h="25.0" x="497.16666" y="2964.6665"/> <glyph class="state variable" id="_1db68709-34da-4bc3-882c-3d410e10b26c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="489.66666" y="2972.1665"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s113_mpk1_mpk1_sa75" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: late endosomal/lysosomal adaptor MODULE:MAPK and MTOR activator 3 MAP2K1IP1 "MODULE:MAPK scaffold protein 1" MAPKSP1 "mitogen-activated protein kinase kinase 1 interacting protein 1" HUGO:LAMTOR3 HGNC:15606 ENTREZ:8649 UNIPROT:Q9UHA4 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MP1 is localised in late endosomes by P14 forming a very stable heterodimeric complex that is required for ERK activation. It is required for efficient and sustained EGF-induced MEK and ERK activation (in late endosomes) PMID:17178906 References_end</body> </html> </notes> <label text="MP1*"/> <bbox w="50.0" h="25.0" x="1562.5" y="2078.5"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s692_mpk1_mpk1_sa416" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MAP kinase interacting serine/threonine kinase 1 HUGO:MKNK1 HGNC:7110 ENTREZ:8569 UNIPROT:Q9BUB5 MAP kinase interacting serine/threonine kinase 2 "G protein-coupled receptor kinase 7" GPRK7 HUGO:MKNK2 HGNC:7111 ENTREZ:2872 UNIPROT:Q9HBH9 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MNKs are cytoplasmic targets of ERK and P38. PMID:15187187 References_end</body> </html> </notes> <label text="MNK*"/> <bbox w="50.0" h="25.0" x="2168.9963" y="2657.0"/> <glyph class="state variable" id="_06a2bcc4-5f7b-4d84-a5cd-39554c76d700"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2163.9963" y="2664.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s693_mpk1_mpk1_sa417" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MAP kinase interacting serine/threonine kinase 1 HUGO:MKNK1 HGNC:7110 ENTREZ:8569 UNIPROT:Q9BUB5 MAP kinase interacting serine/threonine kinase 2 "G protein-coupled receptor kinase 7" GPRK7 HUGO:MKNK2 HGNC:7111 ENTREZ:2872 UNIPROT:Q9HBH9 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MNKs are cytoplasmic targets of ERK and P38. PMID:15187187 References_end</body> </html> </notes> <label text="MNK*"/> <bbox w="50.0" h="25.0" x="2167.163" y="2770.3335"/> <glyph class="state variable" id="_d7b2490c-4e4a-4154-825e-b52c24bc87de"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2159.663" y="2777.8335"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s327_mpk1_mpk1_sa264" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 1 PRKMK1 HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 mitogen-activated protein kinase kinase 2 PRKMK2 HUGO:MAP2K2 HGNC:6842 ENTREZ:5605 UNIPROT:P36507 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: In resting cells MEK1/2 are localised in the cytoplasm and this may be induced by two molecular mechanisms (i.e.: the presence of a nuclear export domain (NES) in their N-terminal domain; the binding to cytoplasmic anchors such as KSR MP1 beta-ARRESTIN-2 Sef1). MEK1 forms a complex with P14 and MP1 on late endosomes necessary for the activation of ERK pathway in this location of the cell. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19565474 PMID:17178906 PMID:15547943 References_end</body> </html> </notes> <label text="MEK*"/> <bbox w="50.0" h="25.0" x="1985.0" y="2517.5"/> <glyph class="state variable" id="_cf4a35bb-7b50-431c-b788-4736077599c6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1980.0" y="2529.1663"/> </glyph> <glyph class="state variable" id="_47bd979f-6c95-46f6-acc0-eaa6f3c70c75"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1980.0" y="2520.626"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s799_mpk1_mpk1_sa554" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 1 PRKMK1 HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 mitogen-activated protein kinase kinase 2 PRKMK2 HUGO:MAP2K2 HGNC:6842 ENTREZ:5605 UNIPROT:P36507 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: In resting cells MEK1/2 are localised in the cytoplasm and this may be induced by two molecular mechanisms (i.e.: the presence of a nuclear export domain (NES) in their N-terminal domain; the binding to cytoplasmic anchors such as KSR MP1 beta-ARRESTIN-2 Sef1). MEK1 forms a complex with P14 and MP1 on late endosomes necessary for the activation of ERK pathway in this location of the cell. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19565474 PMID:17178906 PMID:15547943 References_end</body> </html> </notes> <label text="MEK*"/> <bbox w="50.0" h="25.0" x="1984.9404" y="2663.1904"/> <glyph class="state variable" id="_a499447a-128e-4687-ac89-5b4a36d82ce4"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1977.4404" y="2674.8567"/> </glyph> <glyph class="state variable" id="_c5a4ad82-e63c-4a13-8d89-04915ef8ed53"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1977.4404" y="2666.3164"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s924_mpk1_mpk1_sa679" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 References_end Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 GENECARDS:MDM2 REACTOME:95018 KEGG:4193 ATLASONC:MDM2ID115ch12q15 WIKI:MDM2 Mdm2 p53 binding protein homolog (mouse) Mdm2 p53 binding protein homo Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:CYCLINB MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 PMID:20679392 PMID:15169778 PMID:11923280 PMID:11715018 References_end</body> </html> Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 GENECARDS:MDM2 REACTOME:95018 KEGG:4193 ATLASONC:MDM2ID115ch12q15 WIKI:MDM2 Mdm2 p53 binding protein homolog (mouse) Mdm2 p53 binding protein homo Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:CYCLINB MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 PMID:20679392 PMID:15169778 PMID:11923280 PMID:11715018 References_end</body> </html> </notes> <label text="MDM2"/> <bbox w="50.0" h="25.0" x="3215.0" y="3047.5"/> <glyph class="state variable" id="_9625f029-fdb7-4f82-a49b-aed2be086469"> <state value="" variable="S166"/> <bbox w="30.0" h="10.0" x="3200.0" y="3043.0813"/> </glyph> <glyph class="state variable" id="_e391e17c-f5d2-4a60-a4a0-cf18d9ad1f96"> <state value="" variable="S186"/> <bbox w="30.0" h="10.0" x="3250.0" y="3043.1194"/> </glyph> <glyph class="state variable" id="_46a47809-e478-493d-baeb-ee8c0dd30321"> <state value="" variable="S188"/> <bbox w="30.0" h="10.0" x="3249.6135" y="3067.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s694_mpk1_mpk1_sa418" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MYC associated factor X "MAX protein" HUGO:MAX HGNC:6913 ENTREZ:4149 UNIPROT:P61244 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MAX interacts with the transcription factor C-MYC enabling C-MYC to trans-activate at least a subset of its target genes. MAX is phosphorylated by P38 through complex formation (not represented here). PMID:11274345 References_end</body> </html> </notes> <label text="MAX"/> <bbox w="50.0" h="25.0" x="2927.9963" y="2667.0"/> <glyph class="state variable" id="_168c174f-49d1-405c-b185-6afeb054bea1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2922.9963" y="2674.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s695_mpk1_mpk1_sa419" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MYC associated factor X "MAX protein" HUGO:MAX HGNC:6913 ENTREZ:4149 UNIPROT:P61244 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MAX interacts with the transcription factor C-MYC enabling C-MYC to trans-activate at least a subset of its target genes. MAX is phosphorylated by P38 through complex formation (not represented here). PMID:11274345 References_end</body> </html> </notes> <label text="MAX"/> <bbox w="50.0" h="25.0" x="2929.163" y="2802.3335"/> <glyph class="state variable" id="_5ef6e4fb-cc95-44c6-b668-925adcae2c41"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2921.663" y="2809.8335"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s688_mpk1_mpk1_sa412" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase-activated protein kinase 2 HUGO:MAPKAPK2 HGNC:6887 ENTREZ:9261 UNIPROT:P49137 mitogen-activated protein kinase-activated protein kinase 3 HUGO:MAPKAPK3 HGNC:6888 ENTREZ:7867 UNIPROT:Q16644 mitogen-activated protein kinase-activated protein kinase 5 HUGO:MAPKAPK5 HGNC:6889 ENTREZ:8550 UNIPROT:Q8IW41 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MAPKAPK2 (MK2) MAPKAPK3 (MK3) and MAPKAPK5 (PRAK) are phosphorylated and activated by P38alpha and P38 beta. They catalyse phosphorylation of HSP27. PMID:11274345 References_end</body> </html> </notes> <label text="MAPKAPK*"/> <bbox w="85.0" h="25.0" x="3846.9963" y="2735.0"/> <glyph class="state variable" id="_28384226-b62f-4eca-965e-fb32d5d9fd7a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3841.9963" y="2742.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s689_mpk1_mpk1_sa413" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase-activated protein kinase 2 HUGO:MAPKAPK2 HGNC:6887 ENTREZ:9261 UNIPROT:P49137 mitogen-activated protein kinase-activated protein kinase 3 HUGO:MAPKAPK3 HGNC:6888 ENTREZ:7867 UNIPROT:Q16644 mitogen-activated protein kinase-activated protein kinase 5 HUGO:MAPKAPK5 HGNC:6889 ENTREZ:8550 UNIPROT:Q8IW41 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MAPKAPK2 (MK2) MAPKAPK3 (MK3) and MAPKAPK5 (PRAK) are phosphorylated and activated by P38alpha and P38 beta. They catalyse phosphorylation of HSP27. PMID:11274345 References_end</body> </html> </notes> <label text="MAPKAPK*"/> <bbox w="85.0" h="25.0" x="3648.163" y="2803.0"/> <glyph class="state variable" id="_db31a685-f388-4f58-ae86-90cf3d559217"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3640.663" y="2810.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s45_mpk1_mpk1_sa378" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> </notes> <label text="TAK1*"/> <bbox w="77.0" h="25.0" x="3584.9963" y="1902.0"/> <glyph class="state variable" id="_062fc7a0-8eaa-40f6-a990-982e635734be"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="3570.4705" y="1897.0"/> </glyph> <glyph class="state variable" id="_1373217c-ac91-4b65-aed0-58a45e92a60f"> <state value="" variable="S192"/> <bbox w="30.0" h="10.0" x="3646.4014" y="1922.0"/> </glyph> <glyph class="state variable" id="_1ff8ed34-d6d7-4ef8-ba41-f7a629212dc2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3579.9963" y="1909.5"/> </glyph> <glyph class="state variable" id="_cac3832e-3196-4bcd-8785-cd601a370c0b"> <state value="" variable="T184"/> <bbox w="30.0" h="10.0" x="3570.4705" y="1897.0"/> </glyph> <glyph class="state variable" id="_c70229ae-e959-4c2c-adad-43a22c3b54ea"> <state value="" variable="T178"/> <bbox w="30.0" h="10.0" x="3569.9963" y="1921.8264"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s672_mpk1_mpk1_sa386" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 5 MEKK5 HUGO:MAP3K5 HGNC:6857 ENTREZ:4217 UNIPROT:Q99683 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ASK1 is a MAP3K and can activate both JNK and P38 pathways. TNF-dependent production of ROS triggers the dissociation of Trx from ASK1 and the consequently liberalised ASK1 binds to TRAF2. Finally TRAF2 appears to activate ASK1 (by phosphorylation) by enhancing and stabilising the oligomerisation of ASK1. PMID:11274345 PMID:12655147 References_end</body> </html> </notes> <label text="MAP3K5"/> <bbox w="77.0" h="25.0" x="4008.5" y="1827.5"/> <glyph class="state variable" id="_75126796-8ec6-463d-a41d-12020db0ddc9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4003.5" y="1835.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s671_mpk1_mpk1_sa385" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 4 MEKK4 HUGO:MAP3K4 HGNC:6856 ENTREZ:4216 UNIPROT:Q9Y6R4 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MEKK4 is a MAP3K and can activate both JNK and P38 pathways. It may be an effector for stress pathways activated by genotoxins. PMID:11274345 References_end</body> </html> </notes> <label text="MAP3K4"/> <bbox w="63.0" h="24.0" x="4109.5" y="2257.5"/> <glyph class="state variable" id="_bd8c5fb1-7a84-4b6d-95dc-1a73ebbc0203"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4104.5" y="2264.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s669_mpk1_mpk1_sa383" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 2 MEKK2 HUGO:MAP3K2 HGNC:6854 ENTREZ:10746 UNIPROT:Q9Y2U5 mitogen-activated protein kinase kinase kinase 3 MEKK3 HUGO:MAP3K3 HGNC:6855 ENTREZ:4215 UNIPROT:Q99759 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MEKK2 and MEKK3 can activate JNK P38 and ERK pathways PMID:11274345 References_end</body> </html> </notes> <label text="MAP3K2_3*"/> <bbox w="77.0" h="25.0" x="3337.9963" y="1850.0"/> <glyph class="state variable" id="_88a6c26d-6af6-434e-85e8-88ec69e44861"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3332.9963" y="1857.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s626_mpk1_mpk1_sa390" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 10 MLK2 HUGO:MAP3K10 HGNC:6849 ENTREZ:4294 UNIPROT:Q02779 mitogen-activated protein kinase kinase kinase 11 MLK3 PTK1 HUGO:MAP3K11 HGNC:6850 ENTREZ:4296 UNIPROT:Q16584 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MLK3 and MLK2 two MAP3Ks of JNK pathway can interact with RAC1 in a GTP-dependent manner. MLK3 has the potential to positively regulate the ERK/MODULE:MAPK pathway by directly phosphorylating and activating MEK. PMID:11274345 PMID:12738796 References_end</body> </html> </notes> <label text="MAP3K10_11*"/> <bbox w="50.0" h="25.0" x="2720.9963" y="1838.0"/> <glyph class="state variable" id="_af1b59e3-d4dd-420c-b2fd-cebc4de7b433"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2715.9963" y="1845.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s76_mpk1_mpk1_sa380" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 1 E3 ubiquitin protein ligase MEKK1 "mitogen-activated protein kinase kinase kinase 1" HUGO:MAP3K1 HGNC:6848 ENTREZ:4214 UNIPROT:Q13233 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MEKK1 (MAP3K1) is a key MAP3K. MEKK1 is significantly activated by TNF. Oligomerisation of TRAFs is sufficient to trigger MEKK1 binding. MEKK1 associates selectively with oligomerised TRAF2 in vivo in a TNF-dependent manner. MEKK1 can interact with Ras in a GTP-dependent manner. The GTP-dependent coupling of MEKK1 to Ras indicates that MEKK1 may be an effector for those agonists that recruit JNK through Ras-dependent mechanisms. MEKK1 selectively activates the endogenous JNK pathway. MEKK1 can activate MEK4 and MEK7 in vivo. PMID:18855897 PMID:11274345 References_end</body> </html> </notes> <label text="MAP3K1"/> <bbox w="77.0" h="25.0" x="3179.9963" y="1878.0"/> <glyph class="state variable" id="_c345231b-5c11-4652-b393-7f6814246455"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3174.9963" y="1885.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s678_mpk1_mpk1_sa400" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 7 PRKMK7 HUGO:MAP2K7 HGNC:6847 ENTREZ:5609 UNIPROT:O14733 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MAP2K for JNK pathway. MEK7 is strongly activated by TNF and IL-1. PMID:11274345 References_end</body> </html> </notes> <label text="MAP2K7"/> <bbox w="62.0" h="25.0" x="3115.9963" y="2482.0"/> <glyph class="state variable" id="_373ac605-dd2d-4d24-b9ea-d55a0617b9bb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3110.9963" y="2493.819"/> </glyph> <glyph class="state variable" id="_4f9b62b6-0c4f-4d9a-be6d-ef1ce236e6d2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3110.9963" y="2485.181"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s679_mpk1_mpk1_sa401" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 7 PRKMK7 HUGO:MAP2K7 HGNC:6847 ENTREZ:5609 UNIPROT:O14733 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MAP2K for JNK pathway. MEK7 is strongly activated by TNF and IL-1. PMID:11274345 References_end</body> </html> </notes> <label text="MAP2K7"/> <bbox w="83.0" h="25.0" x="3328.4963" y="2486.3335"/> <glyph class="state variable" id="_f2b3d3bf-710c-4964-979c-ec368cad8b49"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3320.9963" y="2498.1526"/> </glyph> <glyph class="state variable" id="_d7c8c22c-1bd7-4106-8f2a-71cb67e6cee1"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3320.9963" y="2489.5144"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s680_mpk1_mpk1_sa402" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 6 PRKMK6 HUGO:MAP2K6 HGNC:6846 ENTREZ:5608 UNIPROT:P52564 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MAP2K for P38 pathway. MEK6 is activated by all known P38 activators. PMID:11274345 References_end</body> </html> </notes> <label text="MAP2K6"/> <bbox w="83.0" h="25.0" x="4067.9963" y="2484.0"/> <glyph class="state variable" id="_bac13495-a757-41f5-b13f-5bdf2fe5b9fd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4062.9963" y="2495.9302"/> </glyph> <glyph class="state variable" id="_dd96141a-1012-4044-9e78-cf246ca1e12d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4062.9963" y="2487.4385"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s681_mpk1_mpk1_sa403" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 6 PRKMK6 HUGO:MAP2K6 HGNC:6846 ENTREZ:5608 UNIPROT:P52564 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MAP2K for P38 pathway. MEK6 is activated by all known P38 activators. PMID:11274345 References_end</body> </html> </notes> <label text="MAP2K6"/> <bbox w="83.0" h="25.0" x="3868.4963" y="2484.3335"/> <glyph class="state variable" id="_d0a8a70e-7b4a-492c-9175-18d64a0438ca"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3860.9963" y="2496.2637"/> </glyph> <glyph class="state variable" id="_6a19473b-b600-480d-b24a-73eacba75370"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3860.9963" y="2487.772"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s642_mpk1_mpk1_sa393" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 4 SERK1 HUGO:MAP2K4 HGNC:6844 ENTREZ:6416 UNIPROT:P45985 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MAP2K for JNK pathway. MEK4 is weakly activated by TNF and IL-1. PMID:11274345 References_end</body> </html> </notes> <label text="MAP2K4"/> <bbox w="62.0" h="25.0" x="2653.9963" y="2479.0"/> <glyph class="state variable" id="_ce6c5bc3-5bab-4ec1-96f7-d1d0257ab6e2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2648.9963" y="2491.45"/> </glyph> <glyph class="state variable" id="_41a14a55-f243-4eec-87f9-c0657e551e89"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2648.9963" y="2481.8682"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s663_mpk1_mpk1_sa394" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 4 SERK1 HUGO:MAP2K4 HGNC:6844 ENTREZ:6416 UNIPROT:P45985 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MAP2K for JNK pathway. MEK4 is weakly activated by TNF and IL-1. PMID:11274345 References_end</body> </html> </notes> <label text="MAP2K4"/> <bbox w="62.0" h="25.0" x="2928.269" y="2479.5454"/> <glyph class="state variable" id="_fe807e2f-9f6f-420c-bec7-2593a1314200"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2920.769" y="2491.9954"/> </glyph> <glyph class="state variable" id="_6dc079ac-9c8b-472a-b523-6e232ec149f4"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2920.769" y="2482.4136"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s639_mpk1_mpk1_sa392" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 3 PRKMK3 HUGO:MAP2K3 HGNC:6843 ENTREZ:5606 UNIPROT:P46734 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MAP2K for P38 pathway. MEK3 is more strongly activated by physical and chemical stresses than by other stimuli. PMID:11274345 References_end</body> </html> </notes> <label text="MAP2K3"/> <bbox w="83.0" h="25.0" x="3511.9963" y="2485.0"/> <glyph class="state variable" id="_232ca4f9-cd9e-4e55-93b0-7f430f14de8a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3506.9963" y="2496.9302"/> </glyph> <glyph class="state variable" id="_a0b9180f-40b0-4b49-b91a-34a4f88555e4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3506.9963" y="2488.4385"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s664_mpk1_mpk1_sa395" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 3 PRKMK3 HUGO:MAP2K3 HGNC:6843 ENTREZ:5606 UNIPROT:P46734 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MAP2K for P38 pathway. MEK3 is more strongly activated by physical and chemical stresses than by other stimuli. PMID:11274345 References_end</body> </html> </notes> <label text="MAP2K3"/> <bbox w="83.0" h="25.0" x="3707.36" y="2487.5454"/> <glyph class="state variable" id="_3c4571f7-69cf-42c2-94c7-0f00c4f89c00"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3699.86" y="2499.4756"/> </glyph> <glyph class="state variable" id="_7737de80-a527-4c9a-9b3e-358faedb471d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3699.86" y="2490.984"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s114_mpk1_mpk1_sa76" compartmentRef="mpk1_mpk1_c3_mpk1_mpk1_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: late endosomal/lysosomal adaptor MODULE:MAPK and MTOR activator 2 "roadblock domain containing 3" ROBLD3 HUGO:LAMTOR2 HGNC:29796 ENTREZ:28956 UNIPROT:Q9Y2Q5 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: P14 is an adaptor protein responsible for the recruitment of MP1 to late endosomes. P14 is peripherally associated with the cytoplasmic face of late endosomes. PMID:17178906 PMID:12479806 References_end</body> </html> </notes> <label text="LAMTOR2"/> <bbox w="67.5" h="26.5" x="1394.5" y="2224.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s701_mpk1_mpk1_sa426" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> </notes> <label text="JUN"/> <bbox w="50.0" h="25.0" x="2119.9963" y="2914.0"/> <glyph class="state variable" id="_1a10ccfe-389d-47c8-bb4e-2f3e3f599111"> <state value="" variable="S63"/> <bbox w="25.0" h="10.0" x="2107.8042" y="2909.0"/> </glyph> <glyph class="state variable" id="_de1fe6eb-2213-442a-970a-1253dc7886ae"> <state value="" variable="S73"/> <bbox w="25.0" h="10.0" x="2132.5164" y="2909.0"/> </glyph> <glyph class="state variable" id="_9180f7be-3b42-4cf2-be8a-96a34a525e0a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2114.9963" y="2921.5"/> </glyph> <glyph class="state variable" id="_3a5a5a9c-1427-460a-b255-a99bf460576a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2114.9963" y="2909.0"/> </glyph> <glyph class="state variable" id="_f5100f6a-2194-4d9b-9e28-a441457d3f74"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2114.9963" y="2934.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s725_mpk1_mpk1_sa537" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> </notes> <label text="JUN"/> <bbox w="50.0" h="25.0" x="2115.163" y="3051.3335"/> <glyph class="state variable" id="_afb90590-8727-4beb-9b91-b405b5a2c7ac"> <state value="" variable="S63"/> <bbox w="25.0" h="10.0" x="2102.971" y="3046.3335"/> </glyph> <glyph class="state variable" id="_81e187b2-2d3b-4100-8dd1-6e5d80be29fa"> <state value="" variable="S73"/> <bbox w="25.0" h="10.0" x="2127.683" y="3046.3335"/> </glyph> <glyph class="state variable" id="_7f3715a4-8fda-4045-a8c4-38af8c987b57"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2107.663" y="3058.8335"/> </glyph> <glyph class="state variable" id="_d738b27b-a0bb-42b6-9e30-dfcc22c3df08"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2110.163" y="3046.3335"/> </glyph> <glyph class="state variable" id="_aff988c5-8a01-41cc-8c4d-8b064a3ac4ca"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2110.163" y="3071.3335"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s676_mpk1_mpk1_sa398" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: mitogen-activated protein kinase 8 PRKM8 HUGO:MAPK8 HGNC:6881 ENTREZ:5599 UNIPROT:P45983 mitogen-activated protein kinase 9 PRKM9 HUGO:MAPK9 HGNC:6886 ENTREZ:5601 UNIPROT:P45984 mitogen-activated protein kinase 10 PRKM10 HUGO:MAPK10 HGNC:6872 ENTREZ:5602 UNIPROT:P53779 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: mitogen-activated protein kinase 8 PRKM8 HUGO:MAPK8 HGNC:6881 ENTREZ:5599 UNIPROT:P45983 GENECARDS:MAPK8 REACTOME:59293 KEGG:5599 ATLASONC:JNK1ID196 WIKI:MAPK8 mitogen-activated protein kinase 9 PRKM9 HUGO:MAPK9 HGNC:6886 ENTREZ:5601 UNIPROT:P45984 GENECARDS:MAPK9 REACTOME:59295 KEGG:5601 ATLASONC:JNK2ID426 WIKI:MAPK9 mitogen-activated protein kinase 10 PRKM10 HUGO:MAPK10 HGNC:6872 ENTREZ:5602 UNIPROT:P53779 GENECARDS:MAPK10 REACTOME:59297 KEGG:5602 ATLASONC:JNK3ID427 WIKI:MAPK10 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="JNK*"/> <bbox w="50.0" h="25.0" x="3156.9963" y="2587.0"/> <glyph class="state variable" id="_d619a291-4e4a-4d71-991f-e96d00e0b34b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3151.9963" y="2599.2524"/> </glyph> <glyph class="state variable" id="_bfd805b4-79bf-478e-86a2-90b8bea9bbc7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3151.9963" y="2589.7476"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s677_mpk1_mpk1_sa399" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: mitogen-activated protein kinase 8 PRKM8 HUGO:MAPK8 HGNC:6881 ENTREZ:5599 UNIPROT:P45983 mitogen-activated protein kinase 9 PRKM9 HUGO:MAPK9 HGNC:6886 ENTREZ:5601 UNIPROT:P45984 mitogen-activated protein kinase 10 PRKM10 HUGO:MAPK10 HGNC:6872 ENTREZ:5602 UNIPROT:P53779 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: mitogen-activated protein kinase 8 PRKM8 HUGO:MAPK8 HGNC:6881 ENTREZ:5599 UNIPROT:P45983 GENECARDS:MAPK8 REACTOME:59293 KEGG:5599 ATLASONC:JNK1ID196 WIKI:MAPK8 mitogen-activated protein kinase 9 PRKM9 HUGO:MAPK9 HGNC:6886 ENTREZ:5601 UNIPROT:P45984 GENECARDS:MAPK9 REACTOME:59295 KEGG:5601 ATLASONC:JNK2ID426 WIKI:MAPK9 mitogen-activated protein kinase 10 PRKM10 HUGO:MAPK10 HGNC:6872 ENTREZ:5602 UNIPROT:P53779 GENECARDS:MAPK10 REACTOME:59297 KEGG:5602 ATLASONC:JNK3ID427 WIKI:MAPK10 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="JNK*"/> <bbox w="50.0" h="25.0" x="2875.6328" y="2588.0"/> <glyph class="state variable" id="_c63c42e1-d7a1-454a-aad4-4aa67904ac4d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2868.1328" y="2600.2524"/> </glyph> <glyph class="state variable" id="_df93ebb0-1635-46c1-a1a9-ed7697cc1e0d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2868.1328" y="2590.7476"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s796_mpk1_mpk1_sa551" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: mitogen-activated protein kinase 8 PRKM8 HUGO:MAPK8 HGNC:6881 ENTREZ:5599 UNIPROT:P45983 mitogen-activated protein kinase 9 PRKM9 HUGO:MAPK9 HGNC:6886 ENTREZ:5601 UNIPROT:P45984 mitogen-activated protein kinase 10 PRKM10 HUGO:MAPK10 HGNC:6872 ENTREZ:5602 UNIPROT:P53779 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: mitogen-activated protein kinase 8 PRKM8 HUGO:MAPK8 HGNC:6881 ENTREZ:5599 UNIPROT:P45983 GENECARDS:MAPK8 REACTOME:59293 KEGG:5599 ATLASONC:JNK1ID196 WIKI:MAPK8 mitogen-activated protein kinase 9 PRKM9 HUGO:MAPK9 HGNC:6886 ENTREZ:5601 UNIPROT:P45984 GENECARDS:MAPK9 REACTOME:59295 KEGG:5601 ATLASONC:JNK2ID426 WIKI:MAPK9 mitogen-activated protein kinase 10 PRKM10 HUGO:MAPK10 HGNC:6872 ENTREZ:5602 UNIPROT:P53779 GENECARDS:MAPK10 REACTOME:59297 KEGG:5602 ATLASONC:JNK3ID427 WIKI:MAPK10 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="JNK*"/> <bbox w="50.0" h="25.0" x="2348.5715" y="2894.1428"/> <glyph class="state variable" id="_b2acabb2-81b6-43e8-b552-9688e1c07c76"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2341.0715" y="2906.3953"/> </glyph> <glyph class="state variable" id="_6c6a3aa2-924c-40f3-be4c-61676d2b9300"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2341.0715" y="2896.8904"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s29_mpk1_mpk1_sa375" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: interleukin-1 receptor-associated kinase 1 HUGO:IRAK1 HGNC:6112 ENTREZ:3654 UNIPROT:P51617 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Similar to RIP recruitment by TRADD the death domain of receptor-bound MyD88 binds IRAK1. PMID:11274345 References_end</body> </html> </notes> <label text="IRAK1"/> <bbox w="50.0" h="25.0" x="3012.9963" y="1851.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s235_mpk1_mpk1_sa147" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: BRCA1 associated protein HUGO:BRAP HGNC:1099 ENTREZ:8315 UNIPROT:Q7Z569 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: IMP (BRAP) is a RasGTP-interacting protein. It is constitutively bound to KSR1 blocking the enhancement of ERK activation (KSR1 is kept in an inactivated state) maybe recruiting KSR1 to microdomains inaccessible to activators of its function. This could be a mechanism to limit the engagement of ERK cascade in the absence of Ras activation. PMID:14724641 References_end</body> </html> </notes> <label text="IMP*"/> <bbox w="50.0" h="25.0" x="1883.5" y="1870.5"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s31_mpk1_mpk1_sa377" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: interleukin 1 receptor type I IL1R IL1RA HUGO:IL1R1 HGNC:5993 ENTREZ:3554 UNIPROT:P14778 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: IL-1 likely requires TRAF6 to signal to the SAPKs. IL-1 binding to its receptor (IL-1R) triggers heterodimerisation of IL-1R with IL-1RAcP (not modelled) a transmembrane protein necessary for IL-1 signal transduction. The IL-1R/IL-1RAcP heterodimer then recruits the death domain adapter protein MyD88. PMID:11274345 References_end</body> </html> </notes> <label text="IL1R1"/> <bbox w="50.0" h="25.0" x="3037.9963" y="1313.0"/> <glyph class="unit of information" id="_e4e99f91-e8ac-4c35-8925-85a8b49a495e"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="3040.4963" y="1308.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s690_mpk1_mpk1_sa414" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: heat shock 27kDa protein 1 "heat shock 27kD protein 1" HUGO:HSPB1 HGNC:5246 ENTREZ:3315 UNIPROT:P04792 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MAPKAPK2 MAPKAPK3 and PRAK catalyse phosphorylation of HSP27. PMID:11274345 References_end</body> </html> </notes> <label text="HSPB1"/> <bbox w="62.0" h="25.0" x="4047.9963" y="2930.0"/> <glyph class="state variable" id="_bdd881f8-1f88-492e-91bf-2aae36f0d36e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4042.9963" y="2937.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s691_mpk1_mpk1_sa415" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: heat shock 27kDa protein 1 "heat shock 27kD protein 1" HUGO:HSPB1 HGNC:5246 ENTREZ:3315 UNIPROT:P04792 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MAPKAPK2 MAPKAPK3 and PRAK catalyse phosphorylation of HSP27. PMID:11274345 References_end</body> </html> </notes> <label text="HSPB1"/> <bbox w="62.0" h="25.0" x="3862.163" y="3032.0"/> <glyph class="state variable" id="_92cfc79b-de8c-4f7f-b333-741af281a523"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3854.663" y="3039.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s578_mpk1_mpk1_sa343" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end</body> </html> Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end</body> </html> Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end</body> </html> </notes> <label text="GSK3β*"/> <bbox w="63.0" h="27.0" x="749.0" y="2687.0"/> <glyph class="state variable" id="_5280564a-1291-4342-8b89-63f1801a6cff"> <state value="" variable="S9"/> <bbox w="20.0" h="10.0" x="739.3879" y="2682.0"/> </glyph> <glyph class="state variable" id="_7d7d0b79-a37e-4519-9eb6-10ae024a003b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="744.0" y="2695.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s595_mpk1_mpk1_sa357" compartmentRef="mpk1_mpk1_c7_mpk1_mpk1_ca7"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end</body> </html> Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end</body> </html> Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end</body> </html> </notes> <label text="GSK3β*"/> <bbox w="63.0" h="27.0" x="1311.5" y="2101.0"/> <glyph class="state variable" id="_8bd41bd2-c7c8-411f-8257-e464d9fbd9da"> <state value="" variable="S9"/> <bbox w="20.0" h="10.0" x="1301.8878" y="2096.0"/> </glyph> <glyph class="state variable" id="_c453390b-0eb5-46c5-80d9-b8ed55a3cf92"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1306.5" y="2109.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s599_mpk1_mpk1_sa361" compartmentRef="mpk1_mpk1_c7_mpk1_mpk1_ca7"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end</body> </html> Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end</body> </html> Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end</body> </html> </notes> <label text="GSK3β*"/> <bbox w="63.0" h="27.0" x="1311.5" y="2002.0"/> <glyph class="state variable" id="_5ba644a4-78bd-4df1-b5a0-5714ea0a0ac6"> <state value="" variable="S9"/> <bbox w="20.0" h="10.0" x="1301.8878" y="1997.0"/> </glyph> <glyph class="state variable" id="_c44f61fa-a6dc-4e4d-8c42-8663b46b75d8"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1304.0" y="2010.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s957_mpk1_mpk1_sa705" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end</body> </html> Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end</body> </html> Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end</body> </html> </notes> <label text="GSK3β*"/> <bbox w="63.0" h="27.0" x="658.5" y="2736.5"/> <glyph class="state variable" id="_8492a169-7fd9-4046-888a-84d84c935e79"> <state value="" variable="S9"/> <bbox w="20.0" h="10.0" x="648.8879" y="2731.5"/> </glyph> <glyph class="state variable" id="_574e3bea-6c5c-4cce-8199-48ce64ff68e9"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="651.0" y="2745.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s536_mpk1_mpk1_sa311" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adrenergic beta receptor kinase 1 HUGO:ADRBK1 HGNC:289 ENTREZ:156 UNIPROT:P25098 adrenergic beta receptor kinase 2 HUGO:ADRBK2 HGNC:290 ENTREZ:157 UNIPROT:P35626 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN. PMID:11226259 References_end Identifiers_begin: G protein-coupled receptor kinase 1 HUGO:GRK1 HGNC:10013 ENTREZ:6011 UNIPROT:Q15835 GENECARDS:GRK1 KEGG:6011 ATLASONC:GC_GRK1 WIKI:GRK1 G protein-coupled receptor kinase 4 HUGO:GRK4 HGNC:4543 ENTREZ:2868 UNIPROT:P32298 GENECARDS:GRK4 KEGG:2868 ATLASONC:GC_GRK4 WIKI:GRK4 G protein-coupled receptor kinase 5 HUGO:GRK5 HGNC:4544 ENTREZ:2869 UNIPROT:P34947 GENECARDS:GRK5 REACTOME:55956 KEGG:2869 WIKI:GRK5 G protein-coupled receptor kinase 6 HUGO:GRK6 HGNC:4545 ENTREZ:2870 UNIPROT:P43250 GENECARDS:GRK6 KEGG:2870 ATLASONC:GC_GRK6 WIKI:GRK6 G protein-coupled receptor kinase 7 HUGO:GRK7 HGNC:17031 ENTREZ:131890 UNIPROT:Q8WTQ7 GENECARDS:GRK7 KEGG:131890 WIKI:GRK7 adrenergic beta receptor kinase 1 HUGO:ADRBK1 HGNC:289 ENTREZ:156 UNIPROT:P25098 GENECARDS:ADRBK1 REACTOME:50271 KEGG:156 ATLASONC:GC_ADRBK1 WIKI:ADRBK1 adrenergic beta receptor kinase 2 HUGO:ADRBK2 HGNC:290 ENTREZ:157 UNIPROT:P35626 GENECARDS:ADRBK2 KEGG:157 ATLASONC:GC_ADRBK2 WIKI:ADRBK2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK Maps_Modules_end References_begin: PMID:16525728 PMID:15618519 Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN. PMID:11226259 References_end</body> </html> </notes> <label text="GRK*"/> <bbox w="50.0" h="25.0" x="2131.0" y="1837.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s973_mpk1_mpk1_sa716" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 References_end Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 GENECARDS:GRB2 REACTOME:404631 KEGG:2885 ATLASONC:GRB2ID386ch17q25 WIKI:GRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="GRB2"/> <bbox w="50.0" h="25.0" x="491.5" y="1984.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s347_mpk1_mpk1_sa225" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: G protein-coupled receptor 1 HUGO:GPR1 HGNC:4463 ENTREZ:2825 UNIPROT:P46091 G protein-coupled receptor 3 HUGO:GPR3 HGNC:4484 ENTREZ:2827 UNIPROT:P46089 G protein-coupled receptor 4 HUGO:GPR4 HGNC:4497 ENTREZ:2828 UNIPROT:P46093 G protein-coupled receptor 6 HUGO:GPR6 HGNC:4515 ENTREZ:2830 UNIPROT:P46095 G protein-coupled receptor 12 HUGO:GPR12 HGNC:4466 ENTREZ:2835 UNIPROT:P47775 G protein-coupled receptor 15 HUGO:GPR15 HGNC:4469 ENTREZ:2838 UNIPROT:P49685 G protein-coupled receptor 17 HUGO:GPR17 HGNC:4471 ENTREZ:2840 UNIPROT:Q13304 G protein-coupled receptor 18 HUGO:GPR18 HGNC:4472 ENTREZ:2841 UNIPROT:Q14330 G protein-coupled receptor 19 HUGO:GPR19 HGNC:4473 ENTREZ:2842 UNIPROT:Q15760 G protein-coupled receptor 20 HUGO:GPR20 HGNC:4475 ENTREZ:2843 UNIPROT:Q99678 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Phosphorylation of GPCR (by GRK) induces the activation of ERK cascade on eary endosomes. PMID:19565474 References_end</body> </html> </notes> <label text="GPCR*"/> <bbox w="66.0" h="26.0" x="2114.0" y="1314.0"/> <glyph class="state variable" id="_51468917-e0cb-48d5-8076-0738ac0d2f9a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2109.0" y="1322.0"/> </glyph> <glyph class="unit of information" id="_ed2ba772-9424-42c9-bda1-0e40b3b7c58e"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="2124.5" y="1309.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s670_mpk1_mpk1_sa384" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: growth arrest and DNA-damage-inducible alpha DDIT1 HUGO:GADD45A HGNC:4095 ENTREZ:1647 UNIPROT:P24522 growth arrest and DNA-damage-inducible beta MYD118 HUGO:GADD45B HGNC:4096 ENTREZ:4616 UNIPROT:O75293 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Expression of GADD45 is the culmination of a signalling pathway that requires prior expression of the tumour suppressor protein P53 which trans-activates the gadd45 gene. P53 expression is in turn driven by the activity of the ATM gene product. GADD45alpha/beta are direct MEKK4 interactors. They are involved in genotoxin regulation of MEKK4 signalling to JNK and P38. PMID:11274345 References_end</body> </html> </notes> <label text="GADD45*"/> <bbox w="75.0" h="25.0" x="4052.5" y="2577.5"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s975_mpk1_mpk1_sa718" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: GRB2-associated binding protein 1 HUGO:GAB1 HGNC:4066 ENTREZ:2549 UNIPROT:Q13480 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: GRB2-associated binding protein 1 HUGO:GAB1 HGNC:4066 ENTREZ:2549 UNIPROT:Q13480 GENECARDS:GAB1 REACTOME:147726 ATLASONC:GC_GAB1 WIKI:GAB1 GRB2-associated binding protein 2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11313945 PMID:11940581 References_end</body> </html> </notes> <label text="GAB1"/> <bbox w="50.0" h="25.0" x="626.5" y="2026.0"/> <glyph class="state variable" id="_38aa4f5a-900d-4062-a475-7a4052052fe7"> <state value="" variable="Y977"/> <bbox w="30.0" h="10.0" x="611.8078" y="2021.0"/> </glyph> <glyph class="state variable" id="_1ed6a797-ac0f-4977-afa6-41fe95d50677"> <state value="" variable="Y989"/> <bbox w="30.0" h="10.0" x="661.5" y="2021.1343"/> </glyph> <glyph class="state variable" id="_aa89ae65-55be-49d8-9467-d2aca3108f51"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="621.5" y="2033.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s960_mpk1_mpk1_sa708" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>HUGO:FRS2 MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:25772309 Downstream of the signaling tyrosine kinase FGFRs, intracellular signaling cascades are also tightly regulated by specialized adaptor proteins such as FGFR substrate 2?? (FRS2??) and regulators of the RAS???MAPK and PI3K???AKT pathways such as Sprouty (SPRY) proteins Identifiers_begin: fibroblast growth factor receptor substrate 2 HUGO:FRS2 HGNC:16971 ENTREZ:10818 UNIPROT:Q8WU20 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end</body> </html> </notes> <label text="FRS2"/> <bbox w="50.0" h="25.0" x="935.0" y="1327.5"/> <glyph class="state variable" id="_d73bafbb-d2bf-419e-abea-36e761223499"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="930.0" y="1335.0"/> </glyph> <glyph class="state variable" id="_a80ee4e5-c93c-47e9-ab9a-56a8a0c3a2b8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="930.0" y="1335.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s961_mpk1_mpk1_sa709" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>HUGO:FRS2 MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:25772309 Downstream of the signaling tyrosine kinase FGFRs, intracellular signaling cascades are also tightly regulated by specialized adaptor proteins such as FGFR substrate 2?? (FRS2??) and regulators of the RAS???MAPK and PI3K???AKT pathways such as Sprouty (SPRY) proteins Identifiers_begin: fibroblast growth factor receptor substrate 2 HUGO:FRS2 HGNC:16971 ENTREZ:10818 UNIPROT:Q8WU20 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end</body> </html> </notes> <label text="FRS2"/> <bbox w="50.0" h="25.0" x="935.0" y="1507.5"/> <glyph class="state variable" id="_ef945398-bd4e-4973-aa50-51a562e06405"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="930.0" y="1515.0"/> </glyph> <glyph class="state variable" id="_03af0678-71e0-4fa1-ad38-c5984599ba9f"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="927.5" y="1515.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s930_mpk1_mpk1_sa685" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 GENECARDS:FOXO3 REACTOME:199273 KEGG:2309 ATLASONC:AF6q21ID125 WIKI:FOXO3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16288288 PMID:17646672 References_end</body> </html> </notes> <label text="FOXO3"/> <bbox w="65.0" h="22.5" x="2597.5" y="2788.75"/> <glyph class="state variable" id="_14dfdf76-0db7-4123-8f45-e22612457a90"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2625.0" y="2783.75"/> </glyph> <glyph class="state variable" id="_c8df83bc-b34a-4fb5-8844-1819c5b0366b"> <state value="" variable="S644"/> <bbox w="30.0" h="10.0" x="2582.5" y="2806.0938"/> </glyph> <glyph class="state variable" id="_563aa347-2361-49d4-9071-862b3338109c"> <state value="" variable="T32"/> <bbox w="25.0" h="10.0" x="2585.0" y="2784.2732"/> </glyph> <glyph class="state variable" id="_e972545e-e276-4488-882a-bd188e47b3db"> <state value="" variable="S253"/> <bbox w="30.0" h="10.0" x="2647.5" y="2805.761"/> </glyph> <glyph class="state variable" id="_82a96287-2d2e-4015-a282-7d73b39bdc1c"> <state value="" variable="S315"/> <bbox w="30.0" h="10.0" x="2644.723" y="2783.75"/> </glyph> <glyph class="state variable" id="_ebab0713-b647-4aeb-b2da-6af36898ebf9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2592.5" y="2795.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s931_mpk1_mpk1_sa686" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 GENECARDS:FOXO3 REACTOME:199273 KEGG:2309 ATLASONC:AF6q21ID125 WIKI:FOXO3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16288288 PMID:17646672 References_end</body> </html> </notes> <label text="FOXO3"/> <bbox w="65.0" h="22.5" x="2595.0" y="3130.0"/> <glyph class="state variable" id="_c1d8ca94-3b2b-4d56-8f53-fbd371a4068a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2622.5" y="3125.0"/> </glyph> <glyph class="state variable" id="_9fc92266-8f7f-4e7d-ace9-0549ccfef40b"> <state value="" variable="S644"/> <bbox w="30.0" h="10.0" x="2580.0" y="3147.3438"/> </glyph> <glyph class="state variable" id="_b042f683-2268-4f62-a1bd-7b8eb80055fc"> <state value="" variable="T32"/> <bbox w="25.0" h="10.0" x="2582.5" y="3125.5232"/> </glyph> <glyph class="state variable" id="_df320cf1-962b-43e9-be28-48b05c6faea5"> <state value="" variable="S253"/> <bbox w="30.0" h="10.0" x="2645.0" y="3147.011"/> </glyph> <glyph class="state variable" id="_a0e532e3-3925-47e8-a186-dcb5d538d77c"> <state value="" variable="S315"/> <bbox w="30.0" h="10.0" x="2642.223" y="3125.0"/> </glyph> <glyph class="state variable" id="_684632cb-03b8-41a7-a146-85548cc3f637"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2587.5" y="3136.25"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s379_mpk1_mpk1_sa254" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: FBJ murine osteosarcoma viral oncogene homolog "v-fos FBJ murine osteosarcoma viral oncogene homolog" HUGO:FOS HGNC:3796 ENTREZ:2353 UNIPROT:P01100 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: c-FOS is activated by ERK and RSK through phosphorylation. PMID:16393692 References_end Identifiers_begin: FBJ murine osteosarcoma viral oncogene homolog "v-fos FBJ murine osteosarcoma viral oncogene homolog" HUGO:FOS HGNC:3796 ENTREZ:2353 UNIPROT:P01100 GENECARDS:FOS REACTOME:54964 KEGG:2353 ATLASONC:GC_FOS WIKI:FOS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: c-FOS is activated by ERK and RSK through phosphorylation. PMID:16393692 References_end</body> </html> </notes> <label text="FOS"/> <bbox w="50.0" h="25.0" x="1126.0" y="2881.0"/> <glyph class="state variable" id="_25477a3b-182e-48bb-916d-609d32e051c2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1121.0" y="2888.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s723_mpk1_mpk1_sa536" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: FBJ murine osteosarcoma viral oncogene homolog "v-fos FBJ murine osteosarcoma viral oncogene homolog" HUGO:FOS HGNC:3796 ENTREZ:2353 UNIPROT:P01100 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: c-FOS is activated by ERK and RSK through phosphorylation. PMID:16393692 References_end Identifiers_begin: FBJ murine osteosarcoma viral oncogene homolog "v-fos FBJ murine osteosarcoma viral oncogene homolog" HUGO:FOS HGNC:3796 ENTREZ:2353 UNIPROT:P01100 GENECARDS:FOS REACTOME:54964 KEGG:2353 ATLASONC:GC_FOS WIKI:FOS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: c-FOS is activated by ERK and RSK through phosphorylation. PMID:16393692 References_end</body> </html> </notes> <label text="FOS"/> <bbox w="50.0" h="25.0" x="1127.1631" y="3029.3335"/> <glyph class="state variable" id="_73e558d4-55e2-4604-b75e-ec4ffa9f1482"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1119.6631" y="3036.8335"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s21_mpk1_mpk1_sa373" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: endoplasmic reticulum to nucleus signaling 1 "ER to nucleus signalling 1" HUGO:ERN1 HGNC:3449 ENTREZ:2081 UNIPROT:O75460 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ER stress lead to the oligomerisation and activation of mammalian Ire1p (ERN1). ERN1 activation is likely to trigger binding and activation of TRAF2. PMID:11274345 References_end</body> </html> </notes> <label text="ERN1"/> <bbox w="50.0" h="25.0" x="2875.9963" y="1364.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s174_mpk1_mpk1_sa64" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1 REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 GENECARDS:MAPK3 KEGG:5595 ATLASONC:MAPK3ID425ch16p11 WIKI:MAPK3 mitogen-activated protein kinase 4 HUGO:MAPK4 HGNC:6878 ENTREZ:5596 UNIPROT:P31152 GENECARDS:MAPK4 KEGG:5596 ATLASONC:MAPK4ID41293ch18q21 WIKI:MAPK4 mitogen-activated protein kinase 6 HUGO:MAPK6 HGNC:6879 ENTREZ:5597 UNIPROT:Q16659 GENECARDS:MAPK6 KEGG:5597 ATLASONC:MAPK6ID43349ch15q21 WIKI:MAPK6 ERK, ERK2, MAPK2, p41mapk Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end</body> </html> </notes> <label text="ERK*"/> <bbox w="50.0" h="25.0" x="2115.0" y="2592.0"/> <glyph class="state variable" id="_9108c171-30fa-47c2-8e6a-cbdfe630b906"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2110.0" y="2603.8567"/> </glyph> <glyph class="state variable" id="_87956d9b-8bc9-42ba-b8d9-3875fb90edef"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2110.0" y="2594.55"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s387_mpk1_mpk1_sa260" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1 REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 GENECARDS:MAPK3 KEGG:5595 ATLASONC:MAPK3ID425ch16p11 WIKI:MAPK3 mitogen-activated protein kinase 4 HUGO:MAPK4 HGNC:6878 ENTREZ:5596 UNIPROT:P31152 GENECARDS:MAPK4 KEGG:5596 ATLASONC:MAPK4ID41293ch18q21 WIKI:MAPK4 mitogen-activated protein kinase 6 HUGO:MAPK6 HGNC:6879 ENTREZ:5597 UNIPROT:Q16659 GENECARDS:MAPK6 KEGG:5597 ATLASONC:MAPK6ID43349ch15q21 WIKI:MAPK6 ERK, ERK2, MAPK2, p41mapk Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end</body> </html> </notes> <label text="ERK*"/> <bbox w="66.0" h="26.0" x="759.1667" y="2884.5"/> <glyph class="state variable" id="_e7d35868-6317-4186-9758-7fb818ba3d0d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="751.6667" y="2897.031"/> </glyph> <glyph class="state variable" id="_17d7111f-3489-40d4-a85b-8ab1b8f069fb"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="751.6667" y="2887.352"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s594_mpk1_mpk1_sa356" compartmentRef="mpk1_mpk1_c7_mpk1_mpk1_ca7"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1 REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 GENECARDS:MAPK3 KEGG:5595 ATLASONC:MAPK3ID425ch16p11 WIKI:MAPK3 mitogen-activated protein kinase 4 HUGO:MAPK4 HGNC:6878 ENTREZ:5596 UNIPROT:P31152 GENECARDS:MAPK4 KEGG:5596 ATLASONC:MAPK4ID41293ch18q21 WIKI:MAPK4 mitogen-activated protein kinase 6 HUGO:MAPK6 HGNC:6879 ENTREZ:5597 UNIPROT:Q16659 GENECARDS:MAPK6 KEGG:5597 ATLASONC:MAPK6ID43349ch15q21 WIKI:MAPK6 ERK, ERK2, MAPK2, p41mapk Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end</body> </html> </notes> <label text="ERK*"/> <bbox w="50.0" h="25.0" x="1400.5" y="2052.0"/> <glyph class="state variable" id="_3573a3bc-3baa-4b97-9bf4-e9a7c32e0c7e"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1393.0" y="2063.8567"/> </glyph> <glyph class="state variable" id="_2ca6bc8d-2b7e-47f2-816c-18a5d3a7b6f4"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1393.0" y="2054.55"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s603_mpk1_mpk1_sa259" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1 REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 GENECARDS:MAPK3 KEGG:5595 ATLASONC:MAPK3ID425ch16p11 WIKI:MAPK3 mitogen-activated protein kinase 4 HUGO:MAPK4 HGNC:6878 ENTREZ:5596 UNIPROT:P31152 GENECARDS:MAPK4 KEGG:5596 ATLASONC:MAPK4ID41293ch18q21 WIKI:MAPK4 mitogen-activated protein kinase 6 HUGO:MAPK6 HGNC:6879 ENTREZ:5597 UNIPROT:Q16659 GENECARDS:MAPK6 KEGG:5597 ATLASONC:MAPK6ID43349ch15q21 WIKI:MAPK6 ERK, ERK2, MAPK2, p41mapk Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end</body> </html> </notes> <label text="ERK*"/> <bbox w="50.0" h="25.0" x="2307.1667" y="2592.8335"/> <glyph class="state variable" id="_32297681-10e0-4fc5-a6aa-bb7ba448d9cd"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2299.6667" y="2604.6902"/> </glyph> <glyph class="state variable" id="_209080d1-b4b1-42b1-bc9c-14f73dab50dc"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2299.6667" y="2595.3835"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s239_mpk1_mpk1_sa150" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ELK1 member of ETS oncogene family HUGO:ELK1 HGNC:3321 ENTREZ:2002 UNIPROT:P19419 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Elk1 is one of the best studied targets of the ERK cascade. Phosphorylation increases the transcriptional activity of Elk1. PMID:16393692 References_end</body> </html> </notes> <label text="ELK1"/> <bbox w="55.0" h="25.0" x="1376.0" y="2875.0"/> <glyph class="state variable" id="_22ac28f7-8f83-4ee2-8cb3-d58ad3677333"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1371.0" y="2882.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s377_mpk1_mpk1_sa251" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ELK1 member of ETS oncogene family HUGO:ELK1 HGNC:3321 ENTREZ:2002 UNIPROT:P19419 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Elk1 is one of the best studied targets of the ERK cascade. Phosphorylation increases the transcriptional activity of Elk1. PMID:16393692 References_end</body> </html> </notes> <label text="ELK1"/> <bbox w="55.0" h="25.0" x="1375.5" y="3066.0"/> <glyph class="state variable" id="_f86198bf-bde1-4407-8a1a-a1c0bda111d1"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1368.0" y="3073.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s367_mpk1_mpk1_sa245" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: dual specificity phosphatase 6 HUGO:DUSP6 HGNC:3072 ENTREZ:1848 UNIPROT:Q16828 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: DUSP6 may capture activated ERK2 dephosphorylate it and anchor the inactive kinase in the cytoplasm. PMID:17052211 References_end</body> </html> </notes> <label text="DUSP6"/> <bbox w="62.0" h="25.0" x="2302.0" y="2477.0"/> <glyph class="state variable" id="_092cbd1b-b8ea-490d-af4c-738abb9783d4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2297.0" y="2484.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s371_mpk1_mpk1_sa248" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: dual specificity phosphatase 5 HUGO:DUSP5 HGNC:3071 ENTREZ:1847 UNIPROT:Q16690 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: DUSP5 represents an inducible ERK-specific MKP and it functions as both a nuclear anchor and inactivator of ERK MODULE:MAPK in mammalian cells. PMID:17052211 References_end</body> </html> </notes> <label text="DUSP5"/> <bbox w="66.0" h="26.0" x="918.5" y="2980.0"/> <glyph class="state variable" id="_07e059bc-79db-4af3-81df-3c25f3fd6638"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="913.5" y="2988.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s798_mpk1_mpk1_sa553" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: dual specificity phosphatase 5 HUGO:DUSP5 HGNC:3071 ENTREZ:1847 UNIPROT:Q16690 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: DUSP5 represents an inducible ERK-specific MKP and it functions as both a nuclear anchor and inactivator of ERK MODULE:MAPK in mammalian cells. PMID:17052211 References_end</body> </html> </notes> <label text="DUSP5"/> <bbox w="60.0" h="27.0" x="919.5714" y="3092.1428"/> <glyph class="state variable" id="_ac9750bd-e18b-4450-89e5-6b5a53063cac"> <state value="*" variable=""/> <bbox w="15.0" h="10.0" x="912.0714" y="3100.6428"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s788_mpk1_mpk1_sa545" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: dual specificity phosphatase 1 PTPN10 HUGO:DUSP1 HGNC:3064 ENTREZ:1843 UNIPROT:P28562 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MKP-1 (DUSP1) preferentially inactivates JNK and P38. DUSP1 play its phosphatase role in the nucleus. PMID:19436832 PMID:17496916 References_end</body> </html> </notes> <label text="DUSP1"/> <bbox w="62.0" h="25.0" x="2713.0" y="3056.0"/> <glyph class="state variable" id="_f3625023-8fb7-4c72-857b-07b46053220b"> <state value="*" variable=""/> <bbox w="15.0" h="10.0" x="2705.5" y="3063.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s797_mpk1_mpk1_sa552" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: dual specificity phosphatase 1 PTPN10 HUGO:DUSP1 HGNC:3064 ENTREZ:1843 UNIPROT:P28562 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MKP-1 (DUSP1) preferentially inactivates JNK and P38. DUSP1 play its phosphatase role in the nucleus. PMID:19436832 PMID:17496916 References_end</body> </html> </notes> <label text="DUSP1"/> <bbox w="50.0" h="25.0" x="2674.2856" y="2875.1428"/> <glyph class="state variable" id="_6c2ebf85-bcba-4bdb-8297-09442b39392a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2669.2856" y="2882.6428"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s697_mpk1_mpk1_sa421" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DNA-damage-inducible transcript 3 HUGO:DDIT3 HGNC:2726 ENTREZ:1649 UNIPROT:P35638 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: CHOP/GADD153 (DDIT3) mediates in part cell cycle arrest at G1/S an important consequence of DNA damage. It is phosphorylated by P38. PMID:11274345 References_end</body> </html> </notes> <label text="DDIT3"/> <bbox w="67.0" h="24.0" x="3125.9963" y="2908.0"/> <glyph class="state variable" id="_10f9ebe0-baf2-484e-9d65-64d63362c825"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="3120.9963" y="2915.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s698_mpk1_mpk1_sa422" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DNA-damage-inducible transcript 3 HUGO:DDIT3 HGNC:2726 ENTREZ:1649 UNIPROT:P35638 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: CHOP/GADD153 (DDIT3) mediates in part cell cycle arrest at G1/S an important consequence of DNA damage. It is phosphorylated by P38. PMID:11274345 References_end</body> </html> </notes> <label text="DDIT3"/> <bbox w="67.0" h="24.0" x="3124.8298" y="3094.3335"/> <glyph class="state variable" id="_36d91592-bdeb-4356-b1ba-8d0bcd1e809b"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="3117.3298" y="3101.3335"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s585_mpk1_mpk1_sa349" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="72.0" h="26.0" x="263.76923" y="2871.923"/> <glyph class="state variable" id="_00b41c37-7682-430a-8a15-350da8dcca07"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="287.18323" y="2892.923"/> </glyph> <glyph class="state variable" id="_8e713278-7c56-48e9-8394-d0a7e74840ed"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="322.71283" y="2892.923"/> </glyph> <glyph class="state variable" id="_2046ebe3-4443-429a-9e38-33289a463d70"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="323.26923" y="2867.0627"/> </glyph> <glyph class="state variable" id="_9eda9b4a-e08c-449d-ba02-034451cd7f37"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="287.29788" y="2866.923"/> </glyph> <glyph class="state variable" id="_26ee6095-caf4-4986-9d42-cccbfd8c2ac1"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="251.7125" y="2866.923"/> </glyph> <glyph class="state variable" id="_288bb67a-eba5-44ae-a210-3d68f434521f"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="251.26923" y="2892.7427"/> </glyph> <glyph class="state variable" id="_a5ce8b07-1b72-4351-bafc-72ef11d6e067"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="320.76923" y="2867.0627"/> </glyph> <glyph class="state variable" id="_7a82b79f-fecc-49cb-bf79-c3bfb463a0e9"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="320.76923" y="2867.0627"/> </glyph> <glyph class="state variable" id="_313e092b-eb6a-41fe-b3cb-ae83ce55add7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="258.76923" y="2879.923"/> </glyph> <glyph class="state variable" id="_20790b12-6afe-4fb4-8152-b5586a487356"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="249.2125" y="2866.923"/> </glyph> <glyph class="state variable" id="_d3837eb4-84be-42df-b236-10c1e47c06f1"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="320.76923" y="2867.0627"/> </glyph> <glyph class="state variable" id="_5994b059-5236-4ed3-845f-4a9ffa1564d3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="258.76923" y="2874.5383"/> </glyph> <glyph class="state variable" id="_d32df157-f940-43ea-9077-dd36b0cf8dac"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="320.76923" y="2867.0627"/> </glyph> <glyph class="state variable" id="_11546d48-57c3-4498-99e7-5571d6d12c4f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="258.76923" y="2879.923"/> </glyph> <glyph class="state variable" id="_9e8348ca-be95-4d6d-a660-74578a217de1"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="320.21283" y="2892.923"/> </glyph> <glyph class="state variable" id="_66e660f9-dc91-43e4-bdcc-0b15f785da83"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="320.76923" y="2867.0627"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s613_mpk1_mpk1_sa344" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="72.0" h="26.0" x="429.0" y="2745.0"/> <glyph class="state variable" id="_4afa9272-5d4c-4c8b-99c2-8da23c102627"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="452.414" y="2766.0"/> </glyph> <glyph class="state variable" id="_99db670d-1fe0-4acd-a668-52c3ca51b32c"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="487.9436" y="2766.0"/> </glyph> <glyph class="state variable" id="_a28a4fe7-d7ac-4914-bc61-3c4e87d701bc"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="488.5" y="2740.1396"/> </glyph> <glyph class="state variable" id="_c06acb15-4412-4137-b3bc-36649335e55c"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="452.52866" y="2740.0"/> </glyph> <glyph class="state variable" id="_a8167309-eed5-445c-a167-62d1f6a882f5"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="416.94327" y="2740.0"/> </glyph> <glyph class="state variable" id="_da831a24-8cdb-43f3-b6b1-95120bbf785f"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="416.5" y="2765.8196"/> </glyph> <glyph class="state variable" id="_2a3fa76b-0a9a-4570-96fc-f0a4c32614ea"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="486.0" y="2740.1396"/> </glyph> <glyph class="state variable" id="_8ff3d61b-585a-4312-a7d6-2a9bda7ad30f"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="486.0" y="2740.1396"/> </glyph> <glyph class="state variable" id="_64ad58a1-2bef-4a1c-8c16-6edf88f336c0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="424.0" y="2753.0"/> </glyph> <glyph class="state variable" id="_229c8ca1-73b2-4993-8f72-5fa2519d5375"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="414.44327" y="2740.0"/> </glyph> <glyph class="state variable" id="_c82ad94f-daec-4318-a8e7-c607d76e10ee"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="486.0" y="2740.1396"/> </glyph> <glyph class="state variable" id="_9a58c1ae-3ffb-4dbd-9b3b-841afa9a495b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="424.0" y="2747.6152"/> </glyph> <glyph class="state variable" id="_278aa95b-e118-4aa0-a413-2e936b3c92f9"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="486.0" y="2740.1396"/> </glyph> <glyph class="state variable" id="_011fb79d-0111-4334-8d06-a9d6955e1f50"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="424.0" y="2753.0"/> </glyph> <glyph class="state variable" id="_5ea54ef1-7024-4d9c-9913-9aafed6e5eca"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="485.4436" y="2766.0"/> </glyph> <glyph class="state variable" id="_93e924d2-8eed-46f7-b001-ff2009f8acf3"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="486.0" y="2740.1396"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s614_mpk1_mpk1_sa363" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="72.0" h="26.0" x="264.5" y="2746.0"/> <glyph class="state variable" id="_2647717a-cbb7-428e-b580-4dc3e619f1c6"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="287.914" y="2767.0"/> </glyph> <glyph class="state variable" id="_0d7eee27-ba1c-4d6f-944c-910ff2914eaf"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="323.4436" y="2767.0"/> </glyph> <glyph class="state variable" id="_f9a6c165-dd30-4958-b713-8240dca3a267"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="324.0" y="2741.1396"/> </glyph> <glyph class="state variable" id="_0c68d809-e2df-4c50-8b61-d544058d11d8"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="288.02866" y="2741.0"/> </glyph> <glyph class="state variable" id="_9894a545-b308-440d-a31a-fe64158ac143"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="252.44327" y="2741.0"/> </glyph> <glyph class="state variable" id="_5e4c6f80-1227-4492-90c7-337c2dabac34"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="252.0" y="2766.8196"/> </glyph> <glyph class="state variable" id="_6d3d8203-5a81-4e4b-a7a6-88cbede5bb15"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="321.5" y="2741.1396"/> </glyph> <glyph class="state variable" id="_816d7fff-84c1-4da9-9e42-1a4ce99bb8f9"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="321.5" y="2741.1396"/> </glyph> <glyph class="state variable" id="_3043ae62-40f6-4c87-bf02-41595282526b"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="257.0" y="2754.0"/> </glyph> <glyph class="state variable" id="_c25b9071-664b-4ac0-9f3a-5204db202409"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="249.94327" y="2741.0"/> </glyph> <glyph class="state variable" id="_33cd9102-4cd4-4900-84c1-93abddd8eed5"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="321.5" y="2741.1396"/> </glyph> <glyph class="state variable" id="_9fe25b44-4003-4539-9044-b4fc945041c6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="259.5" y="2748.6152"/> </glyph> <glyph class="state variable" id="_c028da49-bdee-41dc-99a8-f135a27d7a24"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="321.5" y="2741.1396"/> </glyph> <glyph class="state variable" id="_d8c5e0e1-ac3e-42a8-9249-d94196d51565"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="259.5" y="2754.0"/> </glyph> <glyph class="state variable" id="_82520938-d2dd-4c80-9ac1-eabcbb48940e"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="320.9436" y="2767.0"/> </glyph> <glyph class="state variable" id="_cb9499e0-d03e-48fb-a240-264aa97dc994"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="321.5" y="2741.1396"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s562_mpk1_mpk1_sa329" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cAMP responsive element binding protein 1 HUGO:CREB1 HGNC:2345 ENTREZ:1385 UNIPROT:P16220 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: CREB activation participates in the transcriptional activation of several immediate-early genes such as c-fos junB and egr1. MSK1 rather than RSK1 mediates the mitogen-stimulated phoshphorylation of CREB. PMID:15187187 References_end</body> </html> </notes> <label text="CREB1"/> <bbox w="50.0" h="25.0" x="579.0" y="3020.0"/> <glyph class="state variable" id="_f18a2eba-2d2e-4882-a87c-ea9b5987f5a0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="574.0" y="3027.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s563_mpk1_mpk1_sa330" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cAMP responsive element binding protein 1 HUGO:CREB1 HGNC:2345 ENTREZ:1385 UNIPROT:P16220 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: CREB activation participates in the transcriptional activation of several immediate-early genes such as c-fos junB and egr1. MSK1 rather than RSK1 mediates the mitogen-stimulated phoshphorylation of CREB. PMID:15187187 References_end</body> </html> </notes> <label text="CREB1"/> <bbox w="50.0" h="25.0" x="499.83334" y="3129.0"/> <glyph class="state variable" id="_09dd21e6-d702-437e-8938-c3430f21f788"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="492.33334" y="3136.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s221_mpk1_mpk1_sa136" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: caspase 9 apoptosis-related cysteine peptidase "caspase 9 apoptosis-related cysteine protease" HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Caspase9 is phosphorylated on Thr125 in a MEK1/2-dependent manner in vivo. Furthermore caspase9 is efficiently phosphorylated on Thr125 by ERK in vitro suggesting that it is targeted directly by ERK in vivo. This is one of the ways ERK plays its anti-apoptotic role. PMID:12792650 References_end Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 GENECARDS:CASP9 REACTOME:57034 KEGG:842 ATLASONC:CASP9ID423ch1p36 WIKI:CASP9 "caspase 9 apoptosis-related cysteine protease" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19788417 PMID:16977332 Caspase9 is phosphorylated on Thr125 in a MEK1/2-dependent manner in vivo. Furthermore caspase9 is efficiently phosphorylated on Thr125 by ERK in vitro suggesting that it is targeted directly by ERK in vivo. This is one of the ways ERK plays its anti-apoptotic role. PMID:12792650 References_end</body> </html> Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 GENECARDS:CASP9 REACTOME:57034 KEGG:842 ATLASONC:CASP9ID423ch1p36 WIKI:CASP9 "caspase 9 apoptosis-related cysteine protease" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19788417 PMID:16977332 Caspase9 is phosphorylated on Thr125 in a MEK1/2-dependent manner in vivo. Furthermore caspase9 is efficiently phosphorylated on Thr125 by ERK in vitro suggesting that it is targeted directly by ERK in vivo. This is one of the ways ERK plays its anti-apoptotic role. PMID:12792650 References_end</body> </html> </notes> <label text="Caspase9*"/> <bbox w="61.0" h="24.0" x="1704.0" y="2409.0"/> <glyph class="state variable" id="_613121fe-5134-4e04-ad3d-4847660ff802"> <state value="" variable="S196"/> <bbox w="30.0" h="10.0" x="1750.0" y="2404.5945"/> </glyph> <glyph class="state variable" id="_36391001-7471-48b0-b748-9f2e9fcd2440"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1699.0" y="2416.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s228_mpk1_mpk1_sa137" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: caspase 9 apoptosis-related cysteine peptidase "caspase 9 apoptosis-related cysteine protease" HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Caspase9 is phosphorylated on Thr125 in a MEK1/2-dependent manner in vivo. Furthermore caspase9 is efficiently phosphorylated on Thr125 by ERK in vitro suggesting that it is targeted directly by ERK in vivo. This is one of the ways ERK plays its anti-apoptotic role. PMID:12792650 References_end Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 GENECARDS:CASP9 REACTOME:57034 KEGG:842 ATLASONC:CASP9ID423ch1p36 WIKI:CASP9 "caspase 9 apoptosis-related cysteine protease" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19788417 PMID:16977332 Caspase9 is phosphorylated on Thr125 in a MEK1/2-dependent manner in vivo. Furthermore caspase9 is efficiently phosphorylated on Thr125 by ERK in vitro suggesting that it is targeted directly by ERK in vivo. This is one of the ways ERK plays its anti-apoptotic role. PMID:12792650 References_end</body> </html> Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 GENECARDS:CASP9 REACTOME:57034 KEGG:842 ATLASONC:CASP9ID423ch1p36 WIKI:CASP9 "caspase 9 apoptosis-related cysteine protease" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19788417 PMID:16977332 Caspase9 is phosphorylated on Thr125 in a MEK1/2-dependent manner in vivo. Furthermore caspase9 is efficiently phosphorylated on Thr125 by ERK in vitro suggesting that it is targeted directly by ERK in vivo. This is one of the ways ERK plays its anti-apoptotic role. PMID:12792650 References_end</body> </html> </notes> <label text="Caspase9*"/> <bbox w="60.0" h="25.0" x="1702.0" y="2326.0"/> <glyph class="state variable" id="_01fd0429-cc07-43fd-ae37-54fb9069be10"> <state value="" variable="S196"/> <bbox w="30.0" h="10.0" x="1747.0" y="2321.6194"/> </glyph> <glyph class="state variable" id="_415ebc91-f093-4e85-ae8b-8175215d2fc7"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1694.5" y="2333.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s183_mpk1_mpk1_sa278" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: caspase 3 apoptosis-related cysteine peptidase "caspase 3 apoptosis-related cysteine protease" HUGO:CASPASE3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: CASPASE3 cleaves KSR1 in apoptotic cells. Thus MEK is sequestered in the cytosol and its interaction with Raf and ERK is prevented. PMID:17613518 References_end Identifiers_begin: caspase 3 apoptosis-related cysteine peptidase "caspase 3 apoptosis-related cysteine protease" HUGO:CASPASE3 GENECARDS:CASPASE3 WIKI:CASPASE3 HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 GENECARDS:CASP3 REACTOME:57022 KEGG:836 ATLASONC:GC_CASP3 WIKI:CASP3 HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 GENECARDS:CASP3 REACTOME:57022 KEGG:836 ATLASONC:GC_CASP3 WIKI:CASP3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: CASPASE3 cleaves KSR1 in apoptotic cells. Thus MEK is sequestered in the cytosol and its interaction with Raf and ERK is prevented. PMID:17613518 References_end</body> </html> </notes> <label text="Caspase3TRUNC*"/> <bbox w="50.0" h="25.0" x="1908.0" y="2261.0"/> <glyph class="unit of information" id="_99dd7e70-0f26-4e3a-a1aa-62bf9addfe41"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="1908.0" y="2256.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s142_mpk1_mpk1_sa48" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: v-raf murine sarcoma viral oncogene homolog B1 HUGO:BRAF HGNC:1097 ENTREZ:673 UNIPROT:P15056 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: B-Raf is the MAPKKK for ERK cascade on plasma membrane. It is phosphorylated by RasGTP and phosphorylates MEK1/2 on plasma membrane. PMID:17496910 References_end</body> </html> </notes> <label text="BRAF"/> <bbox w="66.0" h="26.0" x="1312.5" y="1809.5"/> <glyph class="state variable" id="_b6b699ff-418c-4ac4-9382-5344fa7a4c97"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1307.5" y="1817.5"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s574_mpk1_mpk1_sa339" compartmentRef="mpk1_mpk1_c7_mpk1_mpk1_ca7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: BCL2 protein can target Raf-1 (C-Raf) to mitochondria. PMID:8929532 References_end</body> </html> </notes> <label text="BCL2"/> <bbox w="50.0" h="25.0" x="1132.0" y="1974.5"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s575_mpk1_mpk1_sa340" compartmentRef="mpk1_mpk1_c7_mpk1_mpk1_ca7"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 References_end Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end</body> </html> Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end</body> </html> </notes> <label text="BAD"/> <bbox w="50.0" h="25.0" x="1282.0" y="1945.5"/> <glyph class="state variable" id="_7a51d8d7-fd79-461a-9a8e-95bc8dac9ff2"> <state value="" variable="S112"/> <bbox w="30.0" h="10.0" x="1267.3079" y="1940.5"/> </glyph> <glyph class="state variable" id="_94d0967a-a1cf-47ac-a1b1-1c1ee670a7cb"> <state value="" variable="S136"/> <bbox w="30.0" h="10.0" x="1317.0" y="1940.6343"/> </glyph> <glyph class="state variable" id="_6eac719d-8606-49e0-b26c-6b1411a0bc74"> <state value="" variable="S155"/> <bbox w="30.0" h="10.0" x="1316.6136" y="1965.5"/> </glyph> <glyph class="state variable" id="_407d1ff0-e30b-42cd-a5fa-454705042992"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="1277.0" y="1953.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s576_mpk1_mpk1_sa341" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 References_end Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end</body> </html> Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end</body> </html> </notes> <label text="BAD"/> <bbox w="50.0" h="25.0" x="1244.0" y="1810.5"/> <glyph class="state variable" id="_6e755ec0-19cf-451c-849b-72b9643b7ea6"> <state value="" variable="S112"/> <bbox w="30.0" h="10.0" x="1229.3079" y="1805.5"/> </glyph> <glyph class="state variable" id="_f33aa7ef-cb6c-4140-a7e6-ba0bbb29a341"> <state value="" variable="S136"/> <bbox w="30.0" h="10.0" x="1279.0" y="1805.6343"/> </glyph> <glyph class="state variable" id="_3433ee64-073e-4df2-acd0-fdae5c080231"> <state value="" variable="S155"/> <bbox w="30.0" h="10.0" x="1278.6136" y="1830.5"/> </glyph> <glyph class="state variable" id="_2fdc7970-9ecf-4bba-bcf3-7df8d9069143"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="1236.5" y="1818.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s922_mpk1_mpk1_sa678" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ataxia telangiectasia mutated ATA "ataxia telangiectasia mutated (includes complementation groups A C and D)" ATC ATD ATDC HUGO:ATM HGNC:795 ENTREZ:472 UNIPROT:Q13315 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end</body> </html> </notes> <label text="ATM"/> <bbox w="50.0" h="25.0" x="4165.0" y="2558.5"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s702_mpk1_mpk1_sa427" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: activating transcription factor 2 "cAMP responsive element binding protein 2" CREB2 HUGO:ATF2 HGNC:784 ENTREZ:1386 UNIPROT:P15336 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ATF2 is a nuclear P38 target. ATF2 is a nuclear JNK target. PMID:20506250 PMID:11274345 References_end</body> </html> </notes> <label text="ATF2"/> <bbox w="50.0" h="25.0" x="2455.0" y="2907.5"/> <glyph class="state variable" id="_f696a295-052f-4fb0-8e20-8b58f66858bb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="2450.0" y="2915.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s726_mpk1_mpk1_sa538" compartmentRef="mpk1_mpk1_c4_mpk1_mpk1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: activating transcription factor 2 "cAMP responsive element binding protein 2" CREB2 HUGO:ATF2 HGNC:784 ENTREZ:1386 UNIPROT:P15336 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ATF2 is a nuclear P38 target. ATF2 is a nuclear JNK target. PMID:20506250 PMID:11274345 References_end</body> </html> </notes> <label text="ATF2"/> <bbox w="50.0" h="25.0" x="2455.0" y="3117.5"/> <glyph class="state variable" id="_1ec4091e-c778-4f59-8a35-ebd378ce9d9c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="2447.5" y="3125.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s360_mpk1_mpk1_sa236" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="49.0" h="77.0" x="2515.0" y="1918.0"/> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s948_mpk1_mpk1_sa699" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 GENECARDS:AKT2 REACTOME:49860 KEGG:208 ATLASONC:AKT2ID517ch19q13 WIKI:AKT2 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:CDH2 HGNC:1759 ENTREZ:1000 UNIPROT:P19022 GENECARDS:CDH2 REACTOME:51212 KEGG:1000 ATLASONC:GC_CDH2 WIKI:CDH2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end</body> </html> Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 GENECARDS:AKT2 REACTOME:49860 KEGG:208 ATLASONC:AKT2ID517ch19q13 WIKI:AKT2 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:CDH2 HGNC:1759 ENTREZ:1000 UNIPROT:P19022 GENECARDS:CDH2 REACTOME:51212 KEGG:1000 ATLASONC:GC_CDH2 WIKI:CDH2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end</body> </html> Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 GENECARDS:AKT2 REACTOME:49860 KEGG:208 ATLASONC:AKT2ID517ch19q13 WIKI:AKT2 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:CDH2 HGNC:1759 ENTREZ:1000 UNIPROT:P19022 GENECARDS:CDH2 REACTOME:51212 KEGG:1000 ATLASONC:GC_CDH2 WIKI:CDH2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end</body> </html> </notes> <label text="AKT*"/> <bbox w="50.0" h="25.0" x="635.0" y="2568.5"/> <glyph class="state variable" id="_8aecf00e-c9ba-4f20-a544-bf0478935067"> <state value="" variable="S129"/> <bbox w="30.0" h="10.0" x="620.0" y="2588.3264"/> </glyph> <glyph class="state variable" id="_7b2b83cb-5d90-448a-ad86-b98c065fa085"> <state value="" variable="T450"/> <bbox w="30.0" h="10.0" x="670.0" y="2563.6343"/> </glyph> <glyph class="state variable" id="_a7ca471d-dc92-4600-b89a-a8a90e7c2a98"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="669.61365" y="2588.5"/> </glyph> <glyph class="state variable" id="_06b92e42-103c-4b75-ae16-246b39fc44a7"> <state value="" variable="T308"/> <bbox w="30.0" h="10.0" x="620.3078" y="2563.5"/> </glyph> <glyph class="state variable" id="_1979f116-df2c-463e-a5b3-d131f9f34217"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="680.0" y="2563.5"/> </glyph> <glyph class="state variable" id="_4404b7f2-925a-4a2f-9876-ac84deb4c35b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="630.0" y="2576.0"/> </glyph> </glyph> <glyph class="macromolecule" id="mpk1_mpk1_s950_mpk1_mpk1_sa700" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 GENECARDS:AKT2 REACTOME:49860 KEGG:208 ATLASONC:AKT2ID517ch19q13 WIKI:AKT2 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:CDH2 HGNC:1759 ENTREZ:1000 UNIPROT:P19022 GENECARDS:CDH2 REACTOME:51212 KEGG:1000 ATLASONC:GC_CDH2 WIKI:CDH2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end</body> </html> Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 GENECARDS:AKT2 REACTOME:49860 KEGG:208 ATLASONC:AKT2ID517ch19q13 WIKI:AKT2 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:CDH2 HGNC:1759 ENTREZ:1000 UNIPROT:P19022 GENECARDS:CDH2 REACTOME:51212 KEGG:1000 ATLASONC:GC_CDH2 WIKI:CDH2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end</body> </html> Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 GENECARDS:AKT2 REACTOME:49860 KEGG:208 ATLASONC:AKT2ID517ch19q13 WIKI:AKT2 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:CDH2 HGNC:1759 ENTREZ:1000 UNIPROT:P19022 GENECARDS:CDH2 REACTOME:51212 KEGG:1000 ATLASONC:GC_CDH2 WIKI:CDH2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end</body> </html> </notes> <label text="AKT*"/> <bbox w="50.0" h="25.0" x="635.0" y="2658.5"/> <glyph class="state variable" id="_18e94ef6-664f-409e-bbb1-64d69e10607e"> <state value="" variable="S129"/> <bbox w="30.0" h="10.0" x="620.0" y="2678.3264"/> </glyph> <glyph class="state variable" id="_54af26fa-b9d9-42a4-be2c-24211f7829ef"> <state value="" variable="T450"/> <bbox w="30.0" h="10.0" x="670.0" y="2653.6343"/> </glyph> <glyph class="state variable" id="_311683ca-96f1-449c-b27a-7fedf01ff387"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="669.61365" y="2678.5"/> </glyph> <glyph class="state variable" id="_dc6a3c56-a419-48db-9e3a-1b29316dc798"> <state value="" variable="T308"/> <bbox w="30.0" h="10.0" x="620.3078" y="2653.5"/> </glyph> <glyph class="state variable" id="_b2b3ccf4-807f-45b7-9f9c-7e70dc511339"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="680.0" y="2653.5"/> </glyph> <glyph class="state variable" id="_8530f9ad-f47b-4917-b112-ff76a7051bfc"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="627.5" y="2666.0"/> </glyph> </glyph> <glyph class="simple chemical" id="mpk1_mpk1_s278_mpk1_mpk1_sa169" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Diacylglycerol CAS:N/A PUBCHEM:3914 CHEBI:17815 KEGGCOMPOUND:C00165 Identifiers_end</body> </html> </notes> <label text="DAG"/> <bbox w="70.0" h="25.0" x="330.0" y="1653.5"/> </glyph> <glyph class="simple chemical" id="mpk1_mpk1_s276_mpk1_mpk1_sa167" compartmentRef="mpk1_mpk1_c2_mpk1_mpk1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Phosphatidylinositol 45-bisphosphate References_end</body> </html> </notes> <label text="PIP2"/> <bbox w="70.0" h="25.0" x="212.0" y="1714.5"/> </glyph> <glyph class="simple chemical" id="mpk1_mpk1_s600_mpk1_mpk1_sa388" compartmentRef="mpk1_mpk1_c1_mpk1_mpk1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Reactive oxygen species References_end</body> </html> </notes> <label text="ROS"/> <bbox w="70.0" h="25.0" x="3063.9963" y="1910.5"/> </glyph> <glyph class="simple chemical" id="mpk1_mpk1_s279_mpk1_mpk1_sa170" compartmentRef="mpk1_mpk1_c6_mpk1_mpk1_ca6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Inositol trisphosphate References_end</body> </html> </notes> <label text="IP3"/> <bbox w="70.0" h="25.0" x="202.0" y="1984.5"/> </glyph> <glyph class="complex" id="akt1_s_akt1_s6_akt1_akt1_csa1" compartmentRef="akt1_akt1_c7_akt1_akt1_ca7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GF:RTK* Identifiers_end References_begin: s_akt1_re1(MAP:survival): PMID:12040186 PMID:19568798 PMID:14585353 References_end</body> </html> </notes> <label text="GF:RTK*"/> <bbox w="105.0" h="175.0" x="4669.0" y="140.0"/> <glyph class="simple chemical" id="akt1_akt1_s580_akt1_akt1_sa4"> <label text="GF"/> <bbox w="70.0" h="25.0" x="4683.909" y="157.0"/> </glyph> <glyph class="macromolecule multimer" id="akt1_akt1_s581_akt1_akt1_sa380"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> </notes> <label text="RTK*"/> <bbox w="90.0" h="139.0" x="4676.0" y="163.0"/> <glyph class="unit of information" id="_05f2af0e-7922-4d29-98a3-35e86405d366"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="4711.0" y="158.0"/> </glyph> <glyph class="state variable" id="_ada16c6b-3cac-471e-8945-aa68a76a4206"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4761.0" y="256.28784"/> </glyph> <glyph class="state variable" id="_4a66c947-7de6-475f-84d8-6f8f15700a1d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4758.5" y="256.28784"/> </glyph> <glyph class="state variable" id="_78b3866b-a8e6-4e86-9bc3-4557b9e38540"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4758.5" y="227.5"/> </glyph> <glyph class="unit of information" id="_96892578-930c-4383-97b5-087e6d6256c9"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="4698.5" y="158.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s20_akt1_akt1_csa3" compartmentRef="akt1_akt1_c7_akt1_akt1_ca7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GF:RTK*:p110*:p85* Identifiers_end References_begin: s_akt1_re2(MAP:survival): PMID:12040186 PMID:19568798 PMID:14585353 s_akt1_re3(MAP:survival): PMID:15534002 PMID:9779982 References_end</body> </html> </notes> <label text="GF:RTK*:p110*:p85*"/> <bbox w="201.0" h="178.0" x="4784.909" y="139.5"/> <glyph class="simple chemical" id="akt1_akt1_s15_akt1_akt1_sa7"> <label text="GF"/> <bbox w="70.0" h="25.0" x="4799.8184" y="157.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s33_akt1_akt1_sa31"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: phosphoinositide-3-kinase, regulatory subunit 1 (alpha) HUGO:PIK3R1 HGNC:8979 ENTREZ:5295 UNIPROT:P27986 GENECARDS:PIK3R1 REACTOME:61192 KEGG:5295 ATLASONC:PIK3R1ID41717ch5q13 WIKI:PIK3R1 phosphoinositide-3-kinase, regulatory subunit 2 (beta) HUGO:PIK3R2 HGNC:8980 ENTREZ:5296 UNIPROT:O00459 GENECARDS:PIK3R2 REACTOME:61194 KEGG:5296 ATLASONC:GC_PIK3R2 WIKI:PIK3R2 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) HUGO:PIK3R3 HGNC:8981 ENTREZ:8503 UNIPROT:Q92569 GENECARDS:PIK3R3 REACTOME:61182 KEGG:8503 ATLASONC:GC_PIK3R3 WIKI:PIK3R3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 PMID:19568798 PMID:12040186 References_end Identifiers_begin: phosphoinositide-3-kinase, regulatory subunit 1 (alpha) HUGO:PIK3R1 HGNC:8979 ENTREZ:5295 UNIPROT:P27986 GENECARDS:PIK3R1 REACTOME:61192 KEGG:5295 ATLASONC:PIK3R1ID41717ch5q13 WIKI:PIK3R1 phosphoinositide-3-kinase, regulatory subunit 2 (beta) HUGO:PIK3R2 HGNC:8980 ENTREZ:5296 UNIPROT:O00459 GENECARDS:PIK3R2 REACTOME:61194 KEGG:5296 ATLASONC:GC_PIK3R2 WIKI:PIK3R2 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) HUGO:PIK3R3 HGNC:8981 ENTREZ:8503 UNIPROT:Q92569 GENECARDS:PIK3R3 REACTOME:61182 KEGG:8503 ATLASONC:GC_PIK3R3 WIKI:PIK3R3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 PMID:19568798 PMID:12040186 References_end</body> </html> </notes> <label text="p85*"/> <bbox w="80.0" h="40.0" x="4889.5" y="216.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s34_akt1_akt1_sa32"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: phosphoinositide-3-kinase, catalytic, alpha polypeptide HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 GENECARDS:PIK3CA REACTOME:61074 KEGG:5290 ATLASONC:PIK3CAID415ch3q26 WIKI:PIK3CA phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, delta polypeptide HUGO:PIK3CD HGNC:8977 ENTREZ:5293 UNIPROT:O00329 GENECARDS:PIK3CD REACTOME:61078 KEGG:5293 ATLASONC:PIK3CDID46261ch1p36 WIKI:PIK3CD phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 References_end</body> </html> Identifiers_begin: phosphoinositide-3-kinase, catalytic, alpha polypeptide HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 GENECARDS:PIK3CA REACTOME:61074 KEGG:5290 ATLASONC:PIK3CAID415ch3q26 WIKI:PIK3CA phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, delta polypeptide HUGO:PIK3CD HGNC:8977 ENTREZ:5293 UNIPROT:O00329 GENECARDS:PIK3CD REACTOME:61078 KEGG:5293 ATLASONC:PIK3CDID46261ch1p36 WIKI:PIK3CD phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 References_end</body> </html> </notes> <label text="p110*"/> <bbox w="80.0" h="40.0" x="4889.5" y="256.0"/> <glyph class="state variable" id="_abe3e4fd-169d-42a5-bf64-3d04c8280dfe"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4884.5" y="271.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="akt1_akt1_s578_akt1_akt1_sa381"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> </notes> <label text="RTK*"/> <bbox w="90.0" h="139.0" x="4793.5" y="165.5"/> <glyph class="unit of information" id="_a6294852-75cc-40b3-835c-3fd305210109"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="4828.5" y="160.5"/> </glyph> <glyph class="state variable" id="_b1109b0d-b21f-4f31-9ca9-7461fd962308"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4878.5" y="258.78784"/> </glyph> <glyph class="state variable" id="_aefc8304-d850-44fd-8906-208d8023ad9b"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4876.0" y="258.78784"/> </glyph> <glyph class="state variable" id="_22f48690-1171-44fd-b10d-ca1f83bec158"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="4876.0" y="230.0"/> </glyph> <glyph class="unit of information" id="_671e4626-47ff-4e36-a84a-aefb53e592a3"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="4816.0" y="160.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s26_akt1_akt1_csa7" compartmentRef="akt1_akt1_c7_akt1_akt1_ca7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:RAS*:p110*:p85* Identifiers_end References_begin: s_akt1_re6(MAP:survival): PMID:15534002 PMID:9779982 PMID:14585353 References_end</body> </html> </notes> <label text="RAS*:p110*:p85*"/> <bbox w="176.0" h="116.0" x="4998.0" y="160.5"/> <glyph class="macromolecule" id="akt1_akt1_s30_akt1_akt1_sa23"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> </notes> <label text="RAS*"/> <bbox w="80.0" h="40.0" x="5084.909" y="209.5"/> <glyph class="state variable" id="_a2f69005-60e7-4fc7-831e-a37be5dc5000"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5079.909" y="224.5"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s31_akt1_akt1_sa29"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: phosphoinositide-3-kinase, regulatory subunit 1 (alpha) HUGO:PIK3R1 HGNC:8979 ENTREZ:5295 UNIPROT:P27986 GENECARDS:PIK3R1 REACTOME:61192 KEGG:5295 ATLASONC:PIK3R1ID41717ch5q13 WIKI:PIK3R1 phosphoinositide-3-kinase, regulatory subunit 2 (beta) HUGO:PIK3R2 HGNC:8980 ENTREZ:5296 UNIPROT:O00459 GENECARDS:PIK3R2 REACTOME:61194 KEGG:5296 ATLASONC:GC_PIK3R2 WIKI:PIK3R2 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) HUGO:PIK3R3 HGNC:8981 ENTREZ:8503 UNIPROT:Q92569 GENECARDS:PIK3R3 REACTOME:61182 KEGG:8503 ATLASONC:GC_PIK3R3 WIKI:PIK3R3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 PMID:19568798 PMID:12040186 References_end Identifiers_begin: phosphoinositide-3-kinase, regulatory subunit 1 (alpha) HUGO:PIK3R1 HGNC:8979 ENTREZ:5295 UNIPROT:P27986 GENECARDS:PIK3R1 REACTOME:61192 KEGG:5295 ATLASONC:PIK3R1ID41717ch5q13 WIKI:PIK3R1 phosphoinositide-3-kinase, regulatory subunit 2 (beta) HUGO:PIK3R2 HGNC:8980 ENTREZ:5296 UNIPROT:O00459 GENECARDS:PIK3R2 REACTOME:61194 KEGG:5296 ATLASONC:GC_PIK3R2 WIKI:PIK3R2 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) HUGO:PIK3R3 HGNC:8981 ENTREZ:8503 UNIPROT:Q92569 GENECARDS:PIK3R3 REACTOME:61182 KEGG:8503 ATLASONC:GC_PIK3R3 WIKI:PIK3R3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 PMID:19568798 PMID:12040186 References_end</body> </html> </notes> <label text="p85*"/> <bbox w="80.0" h="40.0" x="5004.5" y="168.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s32_akt1_akt1_sa30"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: phosphoinositide-3-kinase, catalytic, alpha polypeptide HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 GENECARDS:PIK3CA REACTOME:61074 KEGG:5290 ATLASONC:PIK3CAID415ch3q26 WIKI:PIK3CA phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, delta polypeptide HUGO:PIK3CD HGNC:8977 ENTREZ:5293 UNIPROT:O00329 GENECARDS:PIK3CD REACTOME:61078 KEGG:5293 ATLASONC:PIK3CDID46261ch1p36 WIKI:PIK3CD phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 References_end</body> </html> Identifiers_begin: phosphoinositide-3-kinase, catalytic, alpha polypeptide HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 GENECARDS:PIK3CA REACTOME:61074 KEGG:5290 ATLASONC:PIK3CAID415ch3q26 WIKI:PIK3CA phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, delta polypeptide HUGO:PIK3CD HGNC:8977 ENTREZ:5293 UNIPROT:O00329 GENECARDS:PIK3CD REACTOME:61078 KEGG:5293 ATLASONC:PIK3CDID46261ch1p36 WIKI:PIK3CD phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 References_end</body> </html> </notes> <label text="p110*"/> <bbox w="80.0" h="40.0" x="5004.5" y="209.5"/> <glyph class="state variable" id="_f0621c8d-0420-43b4-8af5-b2d2afa702f7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4999.5" y="224.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s42_akt1_akt1_csa10" compartmentRef="akt1_akt1_c7_akt1_akt1_ca7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GAB1:GF:GRB2:PI3,4,5-P3:RAS*:RTK*:SOS*:p110*:p85* Identifiers_end References_begin: s_akt1_re11(MAP:survival): PMID:15584861 PMID:10648629 s_akt1_re3(MAP:survival): PMID:15534002 PMID:9779982 PMID:14585353 References_end</body> </html> </notes> <label text="GAB1:GF:GRB2:PI3,4,5-P3:RAS*:RTK*:SOS*:p110*:p85*"/> <bbox w="282.0" h="232.0" x="5619.0" y="145.0"/> <glyph class="simple chemical" id="akt1_akt1_s583_akt1_akt1_sa48"> <label text="GF"/> <bbox w="70.0" h="25.0" x="5642.5" y="163.0"/> </glyph> <glyph class="simple chemical" id="akt1_akt1_s585_akt1_akt1_sa38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: phosphatidylinositol-3,4,5-triphosphate CAS:N/A PUBCHEM:8260 CHEBI:16618 KEGGCOMPOUND:C05981 Identifiers_end Maps_Modules_begin: MODULE:PI3K_AKT_MTOR Maps_Modules_end</body> </html> </notes> <label text="PI3,4,5-P3"/> <bbox w="70.0" h="25.0" x="5811.5" y="206.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s586_akt1_akt1_sa42"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 References_end Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 GENECARDS:GRB2 REACTOME:404631 KEGG:2885 ATLASONC:GRB2ID386ch17q25 WIKI:GRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="GRB2"/> <bbox w="80.0" h="40.0" x="5727.0" y="232.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s587_akt1_akt1_sa43"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: phosphoinositide-3-kinase, regulatory subunit 1 (alpha) HUGO:PIK3R1 HGNC:8979 ENTREZ:5295 UNIPROT:P27986 GENECARDS:PIK3R1 REACTOME:61192 KEGG:5295 ATLASONC:PIK3R1ID41717ch5q13 WIKI:PIK3R1 phosphoinositide-3-kinase, regulatory subunit 2 (beta) HUGO:PIK3R2 HGNC:8980 ENTREZ:5296 UNIPROT:O00459 GENECARDS:PIK3R2 REACTOME:61194 KEGG:5296 ATLASONC:GC_PIK3R2 WIKI:PIK3R2 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) HUGO:PIK3R3 HGNC:8981 ENTREZ:8503 UNIPROT:Q92569 GENECARDS:PIK3R3 REACTOME:61182 KEGG:8503 ATLASONC:GC_PIK3R3 WIKI:PIK3R3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 PMID:19568798 PMID:12040186 References_end Identifiers_begin: phosphoinositide-3-kinase, regulatory subunit 1 (alpha) HUGO:PIK3R1 HGNC:8979 ENTREZ:5295 UNIPROT:P27986 GENECARDS:PIK3R1 REACTOME:61192 KEGG:5295 ATLASONC:PIK3R1ID41717ch5q13 WIKI:PIK3R1 phosphoinositide-3-kinase, regulatory subunit 2 (beta) HUGO:PIK3R2 HGNC:8980 ENTREZ:5296 UNIPROT:O00459 GENECARDS:PIK3R2 REACTOME:61194 KEGG:5296 ATLASONC:GC_PIK3R2 WIKI:PIK3R2 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) HUGO:PIK3R3 HGNC:8981 ENTREZ:8503 UNIPROT:Q92569 GENECARDS:PIK3R3 REACTOME:61182 KEGG:8503 ATLASONC:GC_PIK3R3 WIKI:PIK3R3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 PMID:19568798 PMID:12040186 References_end</body> </html> </notes> <label text="p85*"/> <bbox w="80.0" h="40.0" x="5808.5" y="274.75"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s588_akt1_akt1_sa44"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Phosphoinositide-3-kinase catalytic subunit p110 HUGO:PI3KCD HGNC:8977 ENTREZ:5293 UNIPROT:O00329 Identifiers_end Maps_Modules_begin: MODULE:PI3K_AKT_MTOR Mapsp_Modules_end References_begin: PMID:16847462 :Three genes ??? PIK3CA, PIK3CB and PIK3CD ??? encode the highly homologous p110 catalytic subunit isoforms p110??, p110?? and p110??, respectively101. They possess an N-terminal p85-binding domain that interacts with the p85 regulatory subunit, a Ras-binding domain (RBD) that mediates activation by the small GTPase Ras, a C2 domain, a phosphatidylinositol kinase homology (PIK) domain and a C-terminal catalytic domain. The PIK and catalytic domains of p110 are homologous to domains found in a family of protein kinases that includes mTOR (mammalian target of rapamycin), ATM (ataxia telangiectasia mutated), ATR (ataxia telangiectasia Rad3 related) and DNA-PK (DNA-dependent serine/threonine protein kinase), indicating that these proteins share an ancient evolutionary origin. PMID:19568798 The 110-kDa catalytic subunit consists of a catalytic lipid kinase domain, a Ras binding domain (RasB), a C2 phospholipid binding domain (protein kinase C homology domain), a helical PI kinase (PIK) domain and an N-terminal domain, which forms a tight association with the regulatory subunit. PMID:12040186 The regulatory sub- unit maintains the p110 catalytic subunit in a low-activity state in quiescent cells and mediates its activation by direct interaction with phosphotyrosine residues of activated growth factor receptors or adaptor proteins. References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: phosphoinositide-3-kinase, catalytic, alpha polypeptide HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 GENECARDS:PIK3CA REACTOME:61074 KEGG:5290 ATLASONC:PIK3CAID415ch3q26 WIKI:PIK3CA phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, delta polypeptide HUGO:PIK3CD HGNC:8977 ENTREZ:5293 UNIPROT:O00329 GENECARDS:PIK3CD REACTOME:61078 KEGG:5293 ATLASONC:PIK3CDID46261ch1p36 WIKI:PIK3CD phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 References_end Identifiers_begin: phosphoinositide-3-kinase, catalytic, alpha polypeptide HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 GENECARDS:PIK3CA REACTOME:61074 KEGG:5290 ATLASONC:PIK3CAID415ch3q26 WIKI:PIK3CA phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, delta polypeptide HUGO:PIK3CD HGNC:8977 ENTREZ:5293 UNIPROT:O00329 GENECARDS:PIK3CD REACTOME:61078 KEGG:5293 ATLASONC:PIK3CDID46261ch1p36 WIKI:PIK3CD phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 References_end</body> </html> </notes> <label text="p110*"/> <bbox w="80.0" h="40.0" x="5808.5" y="317.0"/> <glyph class="state variable" id="_6ea2a089-b147-4132-93c8-d938210308eb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5803.5" y="332.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s605_akt1_akt1_sa45"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: GRB2-associated binding protein 1 HUGO:GAB1 HGNC:4066 ENTREZ:2549 UNIPROT:Q13480 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: GRB2-associated binding protein 1 HUGO:GAB1 HGNC:4066 ENTREZ:2549 UNIPROT:Q13480 GENECARDS:GAB1 REACTOME:147726 ATLASONC:GC_GAB1 WIKI:GAB1 GRB2-associated binding protein 2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11313945 PMID:11940581 References_end</body> </html> </notes> <label text="GAB1"/> <bbox w="80.0" h="40.0" x="5808.5" y="232.5"/> <glyph class="state variable" id="_c9407eb4-dbbb-4818-9d1b-fe0acf90aeec"> <state value="P" variable="Y977"/> <bbox w="35.0" h="10.0" x="5791.4927" y="227.5"/> </glyph> <glyph class="state variable" id="_9f63c1c8-325b-46a0-be04-479cb5d53d6a"> <state value="P" variable="Y989"/> <bbox w="35.0" h="10.0" x="5871.0" y="227.71477"/> </glyph> <glyph class="state variable" id="_b776aa18-4638-4c88-bd1b-3208b83e22c5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5803.5" y="247.5"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s590_akt1_akt1_sa53"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 References_end Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 GENECARDS:SOS1 REACTOME:64848 KEGG:6654 ATLASONC:GC_SOS1 WIKI:SOS1 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 GENECARDS:SOS2 REACTOME:64850 ATLASONC:GC_SOS2 WIKI:SOS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="SOS*"/> <bbox w="80.0" h="40.0" x="5726.5" y="274.75"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s591_akt1_akt1_sa54"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> </notes> <label text="RAS*"/> <bbox w="80.0" h="40.0" x="5727.5" y="317.0"/> <glyph class="state variable" id="_5a260f2b-09f2-41ef-8507-259a7aa28f8f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5722.5" y="332.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="akt1_akt1_s593_akt1_akt1_sa394"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> </notes> <label text="RTK*"/> <bbox w="90.0" h="139.0" x="5638.5454" y="172.45454"/> <glyph class="unit of information" id="_5e69ac8b-1aa4-45d1-8491-b2c86920cf28"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="5673.5454" y="167.45454"/> </glyph> <glyph class="state variable" id="_490d50d4-7a37-47ce-9e52-f240f98d5a55"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5723.5454" y="265.74237"/> </glyph> <glyph class="state variable" id="_cdc43206-5957-477c-b451-0bc2406242db"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5721.0454" y="265.74237"/> </glyph> <glyph class="state variable" id="_272b7ba6-7386-4813-a964-a8e5ab16b5d6"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5721.0454" y="236.95454"/> </glyph> <glyph class="unit of information" id="_dd25caab-9675-4c9f-a73f-3bcadbfb7df7"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="5661.0454" y="167.45454"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s53_akt1_akt1_csa12" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GRB2:SOS* Identifiers_end</body> </html> </notes> <label text="GRB2:SOS*"/> <bbox w="104.0" h="114.0" x="6347.5" y="330.0"/> <glyph class="macromolecule" id="akt1_akt1_s50_akt1_akt1_sa51"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 References_end Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 GENECARDS:GRB2 REACTOME:404631 KEGG:2885 ATLASONC:GRB2ID386ch17q25 WIKI:GRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="GRB2"/> <bbox w="80.0" h="40.0" x="6357.0" y="338.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s51_akt1_akt1_sa52"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 References_end Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 GENECARDS:SOS1 REACTOME:64848 KEGG:6654 ATLASONC:GC_SOS1 WIKI:SOS1 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 GENECARDS:SOS2 REACTOME:64850 ATLASONC:GC_SOS2 WIKI:SOS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="SOS*"/> <bbox w="80.0" h="40.0" x="6358.0" y="385.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s132_akt1_akt1_csa19" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AKT1:HSP90* Identifiers_end References_begin: s_akt1_re41(MAP:survival): PMID:19662498 PMID:19387550 PMID:18566586 s_akt1_re24:(MAP:survival) PMID:18042541 PMID:18077353 References_end</body> </html> </notes> <label text="AKT1:HSP90*"/> <bbox w="101.0" h="107.0" x="6209.0" y="182.0"/> <glyph class="macromolecule" id="akt1_akt1_s133_akt1_akt1_sa107"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Heat shock protein 90 kDa alpha class A member 1 HUGO:HSP90AA1 HGNC:5253 ENTREZ:3320 UNIPROT:P07900 GENECARDS:HSP90AA1 REACTOME:56696 KEGG:3320 ATLASONC:GC_HSP90AA1 WIKI:HSP90AA1 Heat shock protein 90 kDa alpha class A member 2 HUGO:HSP90AA2 HGNC:5256 ENTREZ:3324 UNIPROT:Q14568 GENECARDS:HSP90AA2 ATLASONC:GC_HSP90AA2 WIKI:HSP90AA2 Heat shock protein 90 kDa alpha class B member 1 HUGO:HSP90AB1 HGNC:5258 ENTREZ:3326 UNIPROT:P08238 GENECARDS:HSP90AB1 REACTOME:56698 KEGG:3326 ATLASONC:GC_HSP90AB1 WIKI:HSP90AB1 Heat shock protein 90 kDa beta member 1 HUGO:HSP90B1 HGNC:12028 ENTREZ:7184 UNIPROT:P14625 GENECARDS:HSP90B1 REACTOME:54332 KEGG:7184 ATLASONC:GC_HSP90B1 WIKI:HSP90B1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:HR MAP:dnarepair / MODULE:FANCONI MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19387550 PMID:19662498 PMID:18566586 PMID:10995457 References_end</body> </html> </notes> <label text="HSP90*"/> <bbox w="80.0" h="40.0" x="6215.5" y="186.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s139_akt1_akt1_sa111"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:cellcycle / MODULE:CYCLIND MAP:cellcycle / MODULE:P21CIP MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:cellcycle / MODULE:CYCLIND MAP:cellcycle / MODULE:P21CIP MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end</body> </html> </notes> <label text="AKT1"/> <bbox w="80.0" h="40.0" x="6214.5" y="227.0"/> <glyph class="state variable" id="_b55b0413-9577-4f89-9ad6-0565750e66be"> <state value="" variable="T308"/> <bbox w="30.0" h="10.0" x="6199.5" y="225.77402"/> </glyph> <glyph class="state variable" id="_b4c00e57-34d7-453d-a948-eb10346f947a"> <state value="" variable="T450"/> <bbox w="30.0" h="10.0" x="6279.1333" y="222.0"/> </glyph> <glyph class="state variable" id="_b25cc33e-8be9-4779-91cc-ab44ee532999"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="6279.5" y="261.13065"/> </glyph> <glyph class="state variable" id="_57a4e693-51c2-4f0c-8676-50cc729dbf89"> <state value="P" variable="S129"/> <bbox w="35.0" h="10.0" x="6197.0" y="258.1206"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s155_akt1_akt1_csa22" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HERC1:TSC2 Identifiers_end References_begin: s_akt1_re44:(MAP:survival) PMID:16464865 References_end</body> </html> </notes> <label text="HERC1:TSC2"/> <bbox w="103.0" h="119.0" x="5647.0" y="1114.0"/> <glyph class="macromolecule" id="akt1_akt1_s153_akt1_akt1_sa117"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 GENECARDS:TSC2 REACTOME:404219 KEGG:7249 ATLASONC:TSC2ID184 WIKI:TSC2 P49815 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 GENECARDS:TSC2 REACTOME:404219 KEGG:7249 ATLASONC:TSC2ID184 WIKI:TSC2 P49815 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end</body> </html> </notes> <label text="TSC2"/> <bbox w="80.0" h="40.0" x="5658.0" y="1169.0"/> <glyph class="state variable" id="_906d69d8-ab5e-4d1c-b348-210041ecf81b"> <state value="" variable="S1086"/> <bbox w="35.0" h="10.0" x="5720.5" y="1185.4663"/> </glyph> <glyph class="state variable" id="_ea7fed8d-b27f-4dd8-af40-12ce5e7e8999"> <state value="" variable="S981"/> <bbox w="30.0" h="10.0" x="5719.582" y="1164.0"/> </glyph> <glyph class="state variable" id="_1bcf2999-4462-4c73-b0ee-bb865909de5a"> <state value="" variable="S1130"/> <bbox w="35.0" h="10.0" x="5678.4023" y="1204.0"/> </glyph> <glyph class="state variable" id="_75e30e16-d8db-4528-bf97-a77813d0bf10"> <state value="" variable="T1462"/> <bbox w="35.0" h="10.0" x="5640.9927" y="1164.0"/> </glyph> <glyph class="state variable" id="_bf47c92f-d27d-4761-b755-16d9f2646300"> <state value="" variable="S1132"/> <bbox w="35.0" h="10.0" x="5640.5" y="1202.9485"/> </glyph> <glyph class="state variable" id="_b41005f0-51c4-4971-8880-aa2d9b13b735"> <state value="" variable="S939"/> <bbox w="30.0" h="10.0" x="5681.0303" y="1164.0"/> </glyph> <glyph class="state variable" id="_280f47a6-e37d-4f6e-ac02-f6d237b92e68"> <state value="" variable="S1088"/> <bbox w="35.0" h="10.0" x="5719.882" y="1204.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s154_akt1_akt1_sa118"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1 HUGO:HERC1 HGNC:4867 ENTREZ:8925 UNIPROT:Q15751 GENECARDS:HERC1 KEGG:8925 ATLASONC:GC_HERC1 WIKI:HERC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16464865 PMID:18291711 References_end</body> </html> </notes> <label text="HERC1"/> <bbox w="80.0" h="40.0" x="5657.0" y="1125.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s289_akt1_akt1_csa37" compartmentRef="akt1_akt1_c4_akt1_akt1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:PRAS40* Identifiers_end References_begin: s_akt1_re61:(MAP:survival) PMID:17604271 References_end</body> </html> </notes> <label text="14-3-3*:PRAS40*"/> <bbox w="188.0" h="93.0" x="5895.0" y="2143.0"/> <glyph class="macromolecule" id="akt1_akt1_s291_akt1_akt1_sa201"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="5902.5" y="2164.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s293_akt1_akt1_sa204"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: AKT1 substrate 1 (proline-rich) HUGO:AKT1S1 HGNC:28426 ENTREZ:84335 UNIPROT:Q96B36 GENECARDS:AKT1S1 REACTOME:200146 KEGG:84335 ATLASONC:GC_AKT1S1 WIKI:AKT1S1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18372248 PMID:17604271 References_end</body> </html> </notes> <label text="PRAS40*"/> <bbox w="80.0" h="40.0" x="5990.5" y="2162.0"/> <glyph class="state variable" id="_cc04ab00-ba8a-4944-8675-1b61280c1e96"> <state value="P" variable="S183"/> <bbox w="35.0" h="10.0" x="5973.4927" y="2157.0"/> </glyph> <glyph class="state variable" id="_5f279c22-1622-4404-aac4-849c11b1617d"> <state value="P" variable="T246"/> <bbox w="35.0" h="10.0" x="5973.0" y="2193.1206"/> </glyph> <glyph class="state variable" id="_34d392fa-f4fb-4cc8-a4e3-49752b9ce3a3"> <state value="P" variable="S212"/> <bbox w="35.0" h="10.0" x="6053.0" y="2157.991"/> </glyph> <glyph class="state variable" id="_e57df909-3844-4d09-b61c-c3c093fdbc4c"> <state value="P" variable="S221"/> <bbox w="35.0" h="10.0" x="6053.0" y="2196.1306"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s318_akt1_akt1_csa40" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MLST8:MTOR:RPTOR Identifiers_end References_begin: s_akt1_re65:(MAP:survival) PMID:16286006 s_akt1_re193:(MAP:survival) PMID:20932932 References_end</body> </html> </notes> <label text="MLST8:MTOR:RPTOR"/> <bbox w="80.0" h="60.0" x="4780.4688" y="1193.0"/> <glyph class="macromolecule" id="akt1_akt1_s330_akt1_akt1_sa220"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MTOR associated protein LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 GENECARDS:MLST8 REACTOME:355793 KEGG:64223 WIKI:MLST8 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:12408816 References_end</body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="60.0" x="4780.0" y="1193.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s331_akt1_akt1_sa221"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: regulatory associated protein of MTOR complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 GENECARDS:RPTOR REACTOME:153287 KEGG:57521 ATLASONC:GC_RPTOR WIKI:RPTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19864431 PMID:12150925 PMID:15755954 References_end</body> </html> </notes> <label text="RPTOR"/> <bbox w="80.0" h="60.0" x="4780.0" y="1193.0"/> <glyph class="state variable" id="_bde16a40-3dfe-45fe-8fbf-0f5240d34381"> <state value="P" variable="S696"/> <bbox w="35.0" h="10.0" x="4762.5" y="1217.9523"/> </glyph> <glyph class="state variable" id="_bbbed900-84f1-491c-835a-2058a9e2e20f"> <state value="P" variable="T706"/> <bbox w="35.0" h="10.0" x="4782.221" y="1188.0"/> </glyph> <glyph class="state variable" id="_c4bf68e1-808d-4259-9666-3efbd7b88f7a"> <state value="P" variable="S855"/> <bbox w="35.0" h="10.0" x="4819.449" y="1188.0"/> </glyph> <glyph class="state variable" id="_e9f23bc8-f5d7-4f74-ac93-bc88579dd562"> <state value="P" variable="S863"/> <bbox w="35.0" h="10.0" x="4819.2993" y="1248.0"/> </glyph> <glyph class="state variable" id="_79368e4e-5a93-46e8-9ee5-71faf8e742bc"> <state value="P" variable="S877"/> <bbox w="35.0" h="10.0" x="4783.552" y="1248.0"/> </glyph> <glyph class="state variable" id="_870e7707-a9e7-46e4-a3ba-b539b1b43b20"> <state value="P" variable="S859"/> <bbox w="35.0" h="10.0" x="4842.5" y="1214.6866"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s332_akt1_akt1_sa222"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 GENECARDS:MTOR REACTOME:54978 KEGG:2475 ATLASONC:FRAP1ID40639ch1p36 WIKI:MTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19568798 PMID:17680028 PMID:21157483 References_end</body> </html> </notes> <label text="MTOR"/> <bbox w="80.0" h="60.0" x="4780.0" y="1193.0"/> <glyph class="state variable" id="_95a5465f-d10f-4252-97bb-b6b77f4501e3"> <state value="P" variable="S1261"/> <bbox w="40.0" h="10.0" x="4763.5347" y="1188.0"/> </glyph> <glyph class="state variable" id="_88aeb4bf-b66d-47fe-af49-3745f2e12def"> <state value="" variable="T2446"/> <bbox w="35.0" h="10.0" x="4839.082" y="1188.0"/> </glyph> <glyph class="state variable" id="_7dd6a585-b348-4927-afcf-aa0e9557760f"> <state value="" variable="S2448"/> <bbox w="35.0" h="10.0" x="4841.882" y="1248.0"/> </glyph> <glyph class="state variable" id="_85c98fd7-aa3b-4fd0-b09c-d8b3dc08878d"> <state value="P" variable="S2481"/> <bbox w="40.0" h="10.0" x="4760.0" y="1246.4227"/> </glyph> <glyph class="state variable" id="_8b11ce14-cfac-4459-843f-6f387a22e010"> <state value="" variable="Y631"/> <bbox w="30.0" h="10.0" x="4765.0" y="1218.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s381_akt1_akt1_csa44" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:EIF4A*:PDCD4 Identifiers_end References_begin: s_akt1_re73:(MAP:survival) PMID:17053147 References_end</body> </html> </notes> <label text="EIF4A*:PDCD4"/> <bbox w="100.0" h="120.0" x="5115.0" y="2002.5"/> <glyph class="macromolecule" id="akt1_akt1_s377_akt1_akt1_sa245"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: programmed cell death 4 (neoplastic transformation inhibitor) HUGO:PDCD4 HGNC:8763 ENTREZ:27250 UNIPROT:Q53EL6 GENECARDS:PDCD4 KEGG:27250 ATLASONC:PDCD4ID41675ch10q24 WIKI:PDCD4 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17053147 PMID:19356152 References_end</body> </html> </notes> <label text="PDCD4"/> <bbox w="80.0" h="40.0" x="5125.0" y="2016.5"/> <glyph class="state variable" id="_05009771-96e3-4067-87ae-88f0ef9e7742"> <state value="" variable="S67"/> <bbox w="25.0" h="10.0" x="5151.732" y="2011.5"/> </glyph> <glyph class="state variable" id="_b17bb6a9-9bbb-412e-a7e9-43437ca9c271"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5120.0" y="2031.4681"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s380_akt1_akt1_sa247"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: eukaryotic translation initiation factor 4A1 HUGO:EIF4A1 HGNC:3282 ENTREZ:1973 UNIPROT:P60842 GENECARDS:EIF4A1 REACTOME:72572 KEGG:1973 ATLASONC:GC_EIF4A1 WIKI:EIF4A1 eukaryotic translation initiation factor 4A2 HUGO:EIF4A2 HGNC:3284 ENTREZ:1974 UNIPROT:Q14240 GENECARDS:EIF4A2 REACTOME:72574 KEGG:1974 ATLASONC:EIF4A2ID262 WIKI:EIF4A2 eukaryotic translation initiation factor 4A3 HUGO:EIF4A3 HGNC:18683 ENTREZ:9775 UNIPROT:P38919 GENECARDS:EIF4A3 REACTOME:57148 KEGG:9775 ATLASONC:GC_EIF4A3 WIKI:EIF4A3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12867079 PMID:19339977 References_end</body> </html> </notes> <label text="EIF4A*"/> <bbox w="80.0" h="40.0" x="5126.0" y="2056.5"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s383_akt1_akt1_csa45" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:EIF4A*:PDCD4 Identifiers_end References_begin: s_akt1_re73:(MAP:survival) PMID:17053147 References_end</body> </html> </notes> <label text="EIF4A*:PDCD4"/> <bbox w="100.0" h="120.0" x="5314.5" y="2002.5"/> <glyph class="macromolecule" id="akt1_akt1_s385_akt1_akt1_sa249"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: programmed cell death 4 (neoplastic transformation inhibitor) HUGO:PDCD4 HGNC:8763 ENTREZ:27250 UNIPROT:Q53EL6 GENECARDS:PDCD4 KEGG:27250 ATLASONC:PDCD4ID41675ch10q24 WIKI:PDCD4 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17053147 PMID:19356152 References_end</body> </html> </notes> <label text="PDCD4"/> <bbox w="80.0" h="40.0" x="5324.5" y="2016.5"/> <glyph class="state variable" id="_b20b9295-c14d-41dc-b6a8-e43c72f26c1d"> <state value="P" variable="S67"/> <bbox w="30.0" h="10.0" x="5348.732" y="2011.5"/> </glyph> <glyph class="state variable" id="_6c5bea02-1a4c-47a3-846a-9bdcb375b6b2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5319.5" y="2031.4681"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s384_akt1_akt1_sa250"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: eukaryotic translation initiation factor 4A1 HUGO:EIF4A1 HGNC:3282 ENTREZ:1973 UNIPROT:P60842 GENECARDS:EIF4A1 REACTOME:72572 KEGG:1973 ATLASONC:GC_EIF4A1 WIKI:EIF4A1 eukaryotic translation initiation factor 4A2 HUGO:EIF4A2 HGNC:3284 ENTREZ:1974 UNIPROT:Q14240 GENECARDS:EIF4A2 REACTOME:72574 KEGG:1974 ATLASONC:EIF4A2ID262 WIKI:EIF4A2 eukaryotic translation initiation factor 4A3 HUGO:EIF4A3 HGNC:18683 ENTREZ:9775 UNIPROT:P38919 GENECARDS:EIF4A3 REACTOME:57148 KEGG:9775 ATLASONC:GC_EIF4A3 WIKI:EIF4A3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12867079 PMID:19339977 References_end</body> </html> </notes> <label text="EIF4A*"/> <bbox w="80.0" h="40.0" x="5325.5" y="2056.5"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s420_akt1_akt1_csa49" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DEK:REF*:RNPS1:SKAR*:SRM160*:Y14*:p70_alpha_* Identifiers_end References_begin: s_akt1_re79(MAP:survival): PMID:18423201 PMID:19339977 References_end</body> </html> </notes> <label text="DEK:REF*:RNPS1:SKAR*:SRM160*:Y14*:p70α*"/> <bbox w="202.0" h="194.0" x="4842.0" y="2203.0"/> <glyph class="macromolecule" id="akt1_akt1_s421_akt1_akt1_sa273"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: serine/arginine repetitive matrix 1 HUGO:SRRM1 HGNC:16638 ENTREZ:10250 UNIPROT:Q8IYB3 GENECARDS:SRRM1 REACTOME:249492 KEGG:10250 WIKI:SRRM1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11532962 PMID:18423201 References_end</body> </html> </notes> <label text="SRM160*"/> <bbox w="80.0" h="40.0" x="4856.0" y="2287.597"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s422_akt1_akt1_sa274"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DEK oncogene HUGO:DEK HGNC:2768 ENTREZ:7913 UNIPROT:P35659 GENECARDS:DEK KEGG:7913 ATLASONC:DEK_23 WIKI:DEK Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11532962 References_end</body> </html> </notes> <label text="DEK"/> <bbox w="80.0" h="40.0" x="4856.0" y="2330.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s423_akt1_akt1_sa275"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: PolymeRASe (DNA-directed) delta interacting protein 3 HUGO:POLDIP3 HGNC:23782 ENTREZ:84271 UNIPROT:Q9BY77 GENECARDS:POLDIP3 KEGG:84271 WIKI:POLDIP3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12522211 References_end</body> </html> </notes> <label text="SKAR*"/> <bbox w="80.0" h="40.0" x="4856.0" y="2247.194"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s424_akt1_akt1_sa276"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ribosomal protein S6 kinase 70kDa polypeptide 1 "ribosomal protein S6 kinase 70kD polypeptide 1" STK14A HUGO:RPS6KB1 HGNC:10436 ENTREZ:6198 UNIPROT:P23443 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: ribosomal protein S6 kinase 70kDa polypeptide 1 "ribosomal protein S6 kinase 70kD polypeptide 1" STK14A HUGO:RPS6KB1 HGNC:10436 ENTREZ:6198 UNIPROT:P23443 GENECARDS:RPS6KB1 REACTOME:57803 KEGG:6198 ATLASONC:GC_RPS6KB1 WIKI:RPS6KB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16286006 PMID:20647036 PMID:11108711 References_end</body> </html> </notes> <label text="p70α*"/> <bbox w="80.0" h="40.0" x="4854.0" y="2206.0"/> <glyph class="state variable" id="_62a6b44a-0214-4b10-9fe9-7e9f6733599b"> <state value="P" variable="T389"/> <bbox w="35.0" h="10.0" x="4916.5" y="2238.6543"/> </glyph> <glyph class="state variable" id="_3623be02-b75a-4ec9-93f4-fe5b1a3be439"> <state value="P" variable="T229"/> <bbox w="35.0" h="10.0" x="4836.5" y="2203.402"/> </glyph> <glyph class="state variable" id="_64ad6280-37fd-44ba-81e2-a4847e7914a4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4849.0" y="2221.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s710_akt1_akt1_sa468"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RNA binding protein S1 serine-rich domain HUGO:RNPS1 HGNC:10080 ENTREZ:10921 UNIPROT:Q15287 GENECARDS:RNPS1 REACTOME:156734 KEGG:10921 WIKI:RNPS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11532962 References_end</body> </html> </notes> <label text="RNPS1"/> <bbox w="80.0" h="40.0" x="4939.5" y="2206.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s711_akt1_akt1_sa469"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Aly/REF export factor HUGO:ALYREF HGNC:19071 ENTREZ:10189 UNIPROT:Q86V81 GENECARDS:ALYREF REACTOME:103403 KEGG:10189 ATLASONC:GC_ALYREF WIKI:ALYREF Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:10786854 References_end</body> </html> </notes> <label text="REF*"/> <bbox w="80.0" h="40.0" x="4939.5" y="2247.194"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s712_akt1_akt1_sa470"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RNA binding motif protein 8A HUGO:RBM8A HGNC:9905 ENTREZ:9939 UNIPROT:Q9Y5S9 GENECARDS:RBM8A REACTOME:72303 KEGG:9939 ATLASONC:GC_RBM8A WIKI:RBM8A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11532962 References_end</body> </html> </notes> <label text="Y14*"/> <bbox w="80.0" h="40.0" x="4939.5" y="2287.597"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s462_akt1_akt1_csa52" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:p27KIP1* Identifiers_end References_begin: s_akt1_re97:(MAP:survival) PMID:19887899 References_end</body> </html> </notes> <label text="14-3-3*:p27KIP1*"/> <bbox w="100.0" h="120.0" x="5513.0" y="1119.0"/> <glyph class="macromolecule" id="akt1_akt1_s463_akt1_akt1_sa309"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="5522.5" y="1179.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s464_akt1_akt1_sa310"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27 Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="p27KIP1*"/> <bbox w="80.0" h="40.0" x="5521.5" y="1135.0"/> <glyph class="state variable" id="_e1e3fca3-0592-4d54-b7b7-7a65224fd590"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5556.5" y="1130.0"/> </glyph> <glyph class="state variable" id="_23715486-f1cd-4c7b-a621-e72318746cf4"> <state value="" variable="S157"/> <bbox w="30.0" h="10.0" x="5586.5" y="1130.0"/> </glyph> <glyph class="state variable" id="_8e4ac72c-3398-47e8-92fa-df39e84e3376"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5556.5" y="1170.0"/> </glyph> <glyph class="state variable" id="_9cf80718-511a-4333-938c-e1d55e248a0e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5539.9316" y="1130.0"/> </glyph> <glyph class="state variable" id="_14db3201-88f5-4d73-879a-45475cd4a27d"> <state value="P" variable="S10"/> <bbox w="30.0" h="10.0" x="5506.5" y="1132.4022"/> </glyph> <glyph class="state variable" id="_09736ba6-e6e4-4958-8aa4-4cbf97f87734"> <state value="P" variable="T187"/> <bbox w="35.0" h="10.0" x="5583.382" y="1170.0"/> </glyph> <glyph class="state variable" id="_f5111628-53cd-4eac-991c-3df4fa2feb69"> <state value="P" variable="T157"/> <bbox w="35.0" h="10.0" x="5580.582" y="1130.0"/> </glyph> <glyph class="state variable" id="_8fdc7165-8548-4fc9-a0a3-4a16a889e2f6"> <state value="" variable="T198"/> <bbox w="30.0" h="10.0" x="5506.5" y="1169.7223"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s467_akt1_akt1_csa53" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK4_6*:CyclinD*:p27KIP1* Identifiers_end References_begin: s_akt1_re98:(MAP:survival) PMID:19887899 s_akt1_re183(MAP:survival): PMID:18414028 PMID:9106657 References_end</body> </html> </notes> <label text="CDK4_6*:CyclinD*:p27KIP1*"/> <bbox w="102.0" h="161.0" x="5525.0" y="1308.0"/> <glyph class="macromolecule" id="akt1_akt1_s468_akt1_akt1_sa313"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 References_end</body> </html> </notes> <label text="CyclinD*"/> <bbox w="80.0" h="40.0" x="5531.5" y="1358.0"/> <glyph class="state variable" id="_c9fbcc93-a68c-4738-8357-42b82dd31d66"> <state value="" variable="T286"/> <bbox w="30.0" h="10.0" x="5596.5" y="1353.2147"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s469_akt1_akt1_sa314"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 4 HUGO:CDK4 HGNC:1773 ENTREZ:1019 UNIPROT:P11802 GENECARDS:CDK4 REACTOME:68329 KEGG:1019 ATLASONC:CDK4ID238ch12q14 WIKI:CDK4 cyclin-dependent kinase 6 HUGO:CDK6 HGNC:1777 ENTREZ:1021 UNIPROT:Q00534 GENECARDS:CDK6 REACTOME:68335 KEGG:1021 ATLASONC:GC_CDK6 WIKI:CDK6 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 References_end</body> </html> </notes> <label text="CDK4_6*"/> <bbox w="80.0" h="40.0" x="5526.5" y="1314.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s470_akt1_akt1_sa315"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27 Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="p27KIP1*"/> <bbox w="80.0" h="40.0" x="5533.5" y="1403.0"/> <glyph class="state variable" id="_3e5d4dc3-dfb8-4cca-b32b-6d035d78d778"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5568.5" y="1398.0"/> </glyph> <glyph class="state variable" id="_8c824448-1cfa-4fe4-a525-1a837407f553"> <state value="" variable="S157"/> <bbox w="30.0" h="10.0" x="5598.5" y="1398.0"/> </glyph> <glyph class="state variable" id="_bbd902b1-199c-4953-825b-dad4b75de0a6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5568.5" y="1438.0"/> </glyph> <glyph class="state variable" id="_3a656135-08fa-4648-b85c-fba6a9c39713"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5551.9316" y="1398.0"/> </glyph> <glyph class="state variable" id="_320c7463-6b43-4ed0-ae5e-896c1d5bfa76"> <state value="P" variable="S10"/> <bbox w="30.0" h="10.0" x="5518.5" y="1400.4022"/> </glyph> <glyph class="state variable" id="_0b8a2255-0394-4336-a3a1-599a3d2e9f95"> <state value="P" variable="T187"/> <bbox w="35.0" h="10.0" x="5595.382" y="1438.0"/> </glyph> <glyph class="state variable" id="_e8b9adbf-f761-46af-a2db-ace5b879da80"> <state value="P" variable="T157"/> <bbox w="35.0" h="10.0" x="5592.582" y="1398.0"/> </glyph> <glyph class="state variable" id="_6c242697-abed-4e89-8b92-69f3e422a750"> <state value="" variable="T198"/> <bbox w="30.0" h="10.0" x="5518.5" y="1437.7223"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s479_akt1_akt1_csa54" compartmentRef="akt1_akt1_c2_akt1_akt1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:FOXO3 Identifiers_end References_begin: s_akt1_re104:(MAP:survival) PMID:11154281 References_end</body> </html> </notes> <label text="14-3-3*:FOXO3"/> <bbox w="100.0" h="120.0" x="5215.0" y="1051.0"/> <glyph class="macromolecule" id="akt1_akt1_s483_akt1_akt1_sa321"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 GENECARDS:FOXO3 REACTOME:199273 KEGG:2309 ATLASONC:AF6q21ID125 WIKI:FOXO3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16288288 PMID:17646672 References_end</body> </html> </notes> <label text="FOXO3"/> <bbox w="80.0" h="40.0" x="5227.0" y="1062.0"/> <glyph class="state variable" id="_d063c412-49d8-4dd2-974c-15cec0377081"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5262.0" y="1057.0"/> </glyph> <glyph class="state variable" id="_57d3a565-465f-4386-8357-be417049fcc2"> <state value="" variable="S644"/> <bbox w="30.0" h="10.0" x="5212.0" y="1096.7223"/> </glyph> <glyph class="state variable" id="_16d076e2-c4d7-40c6-bad2-a8a4572a9d3a"> <state value="P" variable="T32"/> <bbox w="30.0" h="10.0" x="5212.0" y="1057.9303"/> </glyph> <glyph class="state variable" id="_50e10250-4431-4cc5-838b-326b1393f914"> <state value="P" variable="S253"/> <bbox w="35.0" h="10.0" x="5289.5" y="1096.1306"/> </glyph> <glyph class="state variable" id="_ad4a41dd-6ee3-417f-9500-56d422f1fedb"> <state value="P" variable="S315"/> <bbox w="35.0" h="10.0" x="5286.082" y="1057.0"/> </glyph> <glyph class="state variable" id="_e5cc3daf-ca9c-4f58-969f-c46a8759d437"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5222.0" y="1077.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s484_akt1_akt1_sa322"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="5226.5" y="1107.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s528_akt1_akt1_csa60" compartmentRef="akt1_akt1_c5_akt1_akt1_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAD:BCL2-XL* Identifiers_end References_begin: s_akt1_re123:(MAP:survival) PMID:10949026 References_end</body> </html> </notes> <label text="BAD:BCL2-XL*"/> <bbox w="100.0" h="118.0" x="6672.5" y="706.0"/> <glyph class="macromolecule" id="akt1_akt1_s531_akt1_akt1_sa354"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 References_end Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end</body> </html> Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end</body> </html> </notes> <label text="BAD"/> <bbox w="80.0" h="40.0" x="6679.5" y="718.0"/> <glyph class="state variable" id="_5f7afaff-8ff8-423a-8a8b-0d600d142e71"> <state value="P" variable="S112"/> <bbox w="35.0" h="10.0" x="6662.4927" y="713.0"/> </glyph> <glyph class="state variable" id="_ad9432b5-92d8-48ab-898f-aecde3b2a6ce"> <state value="P" variable="S136"/> <bbox w="35.0" h="10.0" x="6742.0" y="713.2148"/> </glyph> <glyph class="state variable" id="_d27819a0-82d0-4ecb-9fee-bd148faf1b14"> <state value="" variable="S155"/> <bbox w="30.0" h="10.0" x="6743.882" y="753.0"/> </glyph> <glyph class="state variable" id="_2f47df27-c74c-4500-af57-1cb1e870c9a2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6674.5" y="733.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s529_akt1_akt1_sa355"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: BCL2-like 1BCL2-associated agonist of cell death HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 GENECARDS:BCL2L1 REACTOME:50772 KEGG:598 ATLASONC:BCL2L1ID129ch20q11 WIKI:BCL2L1 BCL2-like 1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:10949026 PMID:18097445 References_end Identifiers_begin: BCL2-like 1BCL2-associated agonist of cell death HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 GENECARDS:BCL2L1 REACTOME:50772 KEGG:598 ATLASONC:BCL2L1ID129ch20q11 WIKI:BCL2L1 BCL2-like 1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:10949026 PMID:18097445 References_end</body> </html> </notes> <label text="BCL2-XL*"/> <bbox w="80.0" h="40.0" x="6680.5" y="762.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s533_akt1_akt1_csa59" compartmentRef="akt1_akt1_c5_akt1_akt1_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAD:BCL2-XL* Identifiers_end References_begin: s_akt1_re123:(MAP:survival) PMID:10949026 References_end</body> </html> </notes> <label text="BAD:BCL2-XL*"/> <bbox w="100.0" h="118.0" x="6556.0" y="710.0"/> <glyph class="macromolecule" id="akt1_akt1_s536_akt1_akt1_sa351"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 References_end Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end</body> </html> Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end</body> </html> </notes> <label text="BAD"/> <bbox w="80.0" h="40.0" x="6563.0" y="722.0"/> <glyph class="state variable" id="_2a139d7a-bb1c-4cb6-ab96-91361b983dd8"> <state value="" variable="S112"/> <bbox w="30.0" h="10.0" x="6548.4927" y="717.0"/> </glyph> <glyph class="state variable" id="_42e36fd9-84fe-46fb-83ac-914e4e602782"> <state value="" variable="S136"/> <bbox w="30.0" h="10.0" x="6628.0" y="717.2148"/> </glyph> <glyph class="state variable" id="_b7ffe1f4-e13c-4e01-b089-5450bb0a6804"> <state value="" variable="S155"/> <bbox w="30.0" h="10.0" x="6627.382" y="757.0"/> </glyph> <glyph class="state variable" id="_de3127d1-28bc-4c76-b926-41a0c7fb8b87"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6558.0" y="737.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s534_akt1_akt1_sa352"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: BCL2-like 1BCL2-associated agonist of cell death HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 GENECARDS:BCL2L1 REACTOME:50772 KEGG:598 ATLASONC:BCL2L1ID129ch20q11 WIKI:BCL2L1 BCL2-like 1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:10949026 PMID:18097445 References_end Identifiers_begin: BCL2-like 1BCL2-associated agonist of cell death HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 GENECARDS:BCL2L1 REACTOME:50772 KEGG:598 ATLASONC:BCL2L1ID129ch20q11 WIKI:BCL2L1 BCL2-like 1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:10949026 PMID:18097445 References_end</body> </html> </notes> <label text="BCL2-XL*"/> <bbox w="80.0" h="40.0" x="6564.0" y="766.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s539_akt1_akt1_csa61" compartmentRef="akt1_akt1_c5_akt1_akt1_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:BAD:BCL2-XL* Identifiers_end References_begin: s_akt1_re125:(MAP:survival) PMID:10949026 References_end</body> </html> </notes> <label text="14-3-3*:BAD:BCL2-XL*"/> <bbox w="106.0" h="174.0" x="6660.0" y="890.0"/> <glyph class="macromolecule" id="akt1_akt1_s544_akt1_akt1_sa358"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 References_end Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end</body> </html> Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end</body> </html> </notes> <label text="BAD"/> <bbox w="80.0" h="40.0" x="6668.25" y="948.0"/> <glyph class="state variable" id="_cc9eaee4-7973-460e-b086-053faa2c441a"> <state value="P" variable="S112"/> <bbox w="35.0" h="10.0" x="6651.2427" y="943.0"/> </glyph> <glyph class="state variable" id="_e900cba2-5fdc-4a11-ac9c-5d0198234005"> <state value="P" variable="S136"/> <bbox w="35.0" h="10.0" x="6730.75" y="943.2148"/> </glyph> <glyph class="state variable" id="_a9446c89-abb6-4e10-bc77-fec91b88005f"> <state value="" variable="S155"/> <bbox w="30.0" h="10.0" x="6732.632" y="983.0"/> </glyph> <glyph class="state variable" id="_902e738f-0402-45f6-86df-96f5d5ec6680"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6663.25" y="963.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s545_akt1_akt1_sa359"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: BCL2-like 1BCL2-associated agonist of cell death HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 GENECARDS:BCL2L1 REACTOME:50772 KEGG:598 ATLASONC:BCL2L1ID129ch20q11 WIKI:BCL2L1 BCL2-like 1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:10949026 PMID:18097445 References_end Identifiers_begin: BCL2-like 1BCL2-associated agonist of cell death HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 GENECARDS:BCL2L1 REACTOME:50772 KEGG:598 ATLASONC:BCL2L1ID129ch20q11 WIKI:BCL2L1 BCL2-like 1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:10949026 PMID:18097445 References_end</body> </html> </notes> <label text="BCL2-XL*"/> <bbox w="80.0" h="40.0" x="6668.5" y="994.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s546_akt1_akt1_sa360"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="6667.5" y="901.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s547_akt1_akt1_csa62" compartmentRef="akt1_akt1_c5_akt1_akt1_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:BAD:BCL2-XL* Identifiers_end References_begin: s_akt1_re126:(MAP:survival) PMID:10949026 References_end</body> </html> </notes> <label text="14-3-3*:BAD:BCL2-XL*"/> <bbox w="109.0" h="166.0" x="6528.5" y="898.5"/> <glyph class="macromolecule" id="akt1_akt1_s553_akt1_akt1_sa361"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 References_end Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end</body> </html> Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end</body> </html> </notes> <label text="BAD"/> <bbox w="80.0" h="40.0" x="6541.75" y="953.5"/> <glyph class="state variable" id="_4cee685a-84bd-4c3b-bf2e-af90af75b0e4"> <state value="P" variable="S112"/> <bbox w="35.0" h="10.0" x="6524.7427" y="948.5"/> </glyph> <glyph class="state variable" id="_6b6bcec8-fc46-403a-ac07-1bf9f5bdca4e"> <state value="P" variable="S136"/> <bbox w="35.0" h="10.0" x="6604.25" y="948.7148"/> </glyph> <glyph class="state variable" id="_b7e56618-8757-4351-8915-34a8c0010283"> <state value="P" variable="S155"/> <bbox w="35.0" h="10.0" x="6603.632" y="988.5"/> </glyph> <glyph class="state variable" id="_3087b8c0-fd3e-462c-89c1-dac451b7cdf6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6536.75" y="968.5"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s554_akt1_akt1_sa362"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: BCL2-like 1BCL2-associated agonist of cell death HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 GENECARDS:BCL2L1 REACTOME:50772 KEGG:598 ATLASONC:BCL2L1ID129ch20q11 WIKI:BCL2L1 BCL2-like 1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:10949026 PMID:18097445 References_end Identifiers_begin: BCL2-like 1BCL2-associated agonist of cell death HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 GENECARDS:BCL2L1 REACTOME:50772 KEGG:598 ATLASONC:BCL2L1ID129ch20q11 WIKI:BCL2L1 BCL2-like 1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:10949026 PMID:18097445 References_end</body> </html> </notes> <label text="BCL2-XL*"/> <bbox w="80.0" h="40.0" x="6542.0" y="995.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s555_akt1_akt1_sa363"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="6543.0" y="909.5"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s560_akt1_akt1_csa63" compartmentRef="akt1_akt1_c5_akt1_akt1_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:BAD Identifiers_end References_begin: s_akt1_re127:(MAP:survival) PMID:10949026 References_end</body> </html> </notes> <label text="14-3-3*:BAD"/> <bbox w="108.0" h="129.0" x="6417.0" y="910.0"/> <glyph class="macromolecule" id="akt1_akt1_s562_akt1_akt1_sa364"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="6430.5" y="976.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s563_akt1_akt1_sa365"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 References_end Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end</body> </html> Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end</body> </html> </notes> <label text="BAD"/> <bbox w="80.0" h="40.0" x="6430.25" y="928.0"/> <glyph class="state variable" id="_08228751-6ebb-4f95-bc79-46823c216c17"> <state value="P" variable="S112"/> <bbox w="35.0" h="10.0" x="6413.2427" y="923.0"/> </glyph> <glyph class="state variable" id="_82657b29-f3ae-4f69-8fc2-b7b4745728c1"> <state value="P" variable="S136"/> <bbox w="35.0" h="10.0" x="6492.75" y="923.2148"/> </glyph> <glyph class="state variable" id="_ce2ba1ab-c3be-4223-8893-174391fcafc4"> <state value="P" variable="S155"/> <bbox w="35.0" h="10.0" x="6492.132" y="963.0"/> </glyph> <glyph class="state variable" id="_f8727043-2e2c-4b05-a050-22d8001d8324"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6425.25" y="943.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s561_akt1_akt1_csa64" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:BAD Identifiers_end</body> </html> </notes> <label text="14-3-3*:BAD"/> <bbox w="108.0" h="129.0" x="6279.5" y="863.5"/> <glyph class="macromolecule" id="akt1_akt1_s559_akt1_akt1_sa368"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="6293.0" y="929.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s557_akt1_akt1_sa369"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 References_end Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end</body> </html> Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end</body> </html> </notes> <label text="BAD"/> <bbox w="80.0" h="40.0" x="6292.75" y="881.5"/> <glyph class="state variable" id="_ed42cf73-6083-49a2-962a-8c3c4bce850d"> <state value="P" variable="S112"/> <bbox w="35.0" h="10.0" x="6275.7427" y="876.5"/> </glyph> <glyph class="state variable" id="_32c3b069-9c75-4cfc-8f5b-4b5819cac912"> <state value="P" variable="S136"/> <bbox w="35.0" h="10.0" x="6355.25" y="876.7148"/> </glyph> <glyph class="state variable" id="_607c298f-79b5-441b-bdd8-47ecc5fee755"> <state value="P" variable="S155"/> <bbox w="35.0" h="10.0" x="6354.632" y="916.5"/> </glyph> <glyph class="state variable" id="_bdd5f4e4-d76b-457b-af10-93e37c51398a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6287.75" y="896.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s579_akt1_akt1_csa66" compartmentRef="akt1_akt1_c6_akt1_akt1_ca6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GF:RTK* Identifiers_end References_begin: s_akt1_re137(MAP:survival): PMID:10514377 PMID:17635922 References_end</body> </html> </notes> <label text="GF:RTK*"/> <bbox w="105.0" h="175.0" x="6500.75" y="169.5"/> <glyph class="simple chemical" id="akt1_akt1_s12_akt1_akt1_sa382"> <label text="GF"/> <bbox w="70.0" h="25.0" x="6515.659" y="186.5"/> </glyph> <glyph class="macromolecule multimer" id="akt1_akt1_s577_akt1_akt1_sa383"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> </notes> <label text="RTK*"/> <bbox w="90.0" h="139.0" x="6507.75" y="192.5"/> <glyph class="unit of information" id="_87c27442-b8bf-414c-bb4f-37a447357b57"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="6542.75" y="187.5"/> </glyph> <glyph class="state variable" id="_cd4729ba-3ad6-443e-a9ce-c07ca16dbd26"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6592.75" y="285.78784"/> </glyph> <glyph class="state variable" id="_923c59e6-ad0b-4057-824c-7994d6ee0120"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="6590.25" y="285.78784"/> </glyph> <glyph class="state variable" id="_24db4d47-abad-45ab-822b-b24aae9c4158"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="6590.25" y="257.0"/> </glyph> <glyph class="unit of information" id="_8072f700-df1f-41af-b2fc-e954e9f9607a"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="6530.25" y="187.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s582_akt1_akt1_csa67" compartmentRef="akt1_akt1_c6_akt1_akt1_ca6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GAB1:GF:GRB2:PI3,4,5-P3:RAS*:RTK*:SOS*:p110*:p85* Identifiers_end References_begin: s_akt1_re136(MAP:survival): PMID:10514377 PMID:17635922 References_end</body> </html> </notes> <label text="GAB1:GF:GRB2:PI3,4,5-P3:RAS*:RTK*:SOS*:p110*:p85*"/> <bbox w="282.0" h="232.0" x="6500.5" y="359.0"/> <glyph class="simple chemical" id="akt1_akt1_s49_akt1_akt1_sa384"> <label text="GF"/> <bbox w="70.0" h="25.0" x="6524.0" y="377.0"/> </glyph> <glyph class="simple chemical" id="akt1_akt1_s46_akt1_akt1_sa386"> <label text="PI3,4,5-P3"/> <bbox w="70.0" h="25.0" x="6693.0" y="420.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s41_akt1_akt1_sa387"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 References_end Identifiers_begin: growth factor receptor-bound protein 2 HUGO:GRB2 HGNC:4566 ENTREZ:2885 UNIPROT:P62993 GENECARDS:GRB2 REACTOME:404631 KEGG:2885 ATLASONC:GRB2ID386ch17q25 WIKI:GRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Grb2 is an adaptor protein normally present in cytosol. It is recruited to the plasma membrane by activated RTK. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="GRB2"/> <bbox w="80.0" h="40.0" x="6608.5" y="446.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s44_akt1_akt1_sa388"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: phosphoinositide-3-kinase, regulatory subunit 1 (alpha) HUGO:PIK3R1 HGNC:8979 ENTREZ:5295 UNIPROT:P27986 GENECARDS:PIK3R1 REACTOME:61192 KEGG:5295 ATLASONC:PIK3R1ID41717ch5q13 WIKI:PIK3R1 phosphoinositide-3-kinase, regulatory subunit 2 (beta) HUGO:PIK3R2 HGNC:8980 ENTREZ:5296 UNIPROT:O00459 GENECARDS:PIK3R2 REACTOME:61194 KEGG:5296 ATLASONC:GC_PIK3R2 WIKI:PIK3R2 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) HUGO:PIK3R3 HGNC:8981 ENTREZ:8503 UNIPROT:Q92569 GENECARDS:PIK3R3 REACTOME:61182 KEGG:8503 ATLASONC:GC_PIK3R3 WIKI:PIK3R3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 PMID:19568798 PMID:12040186 References_end Identifiers_begin: phosphoinositide-3-kinase, regulatory subunit 1 (alpha) HUGO:PIK3R1 HGNC:8979 ENTREZ:5295 UNIPROT:P27986 GENECARDS:PIK3R1 REACTOME:61192 KEGG:5295 ATLASONC:PIK3R1ID41717ch5q13 WIKI:PIK3R1 phosphoinositide-3-kinase, regulatory subunit 2 (beta) HUGO:PIK3R2 HGNC:8980 ENTREZ:5296 UNIPROT:O00459 GENECARDS:PIK3R2 REACTOME:61194 KEGG:5296 ATLASONC:GC_PIK3R2 WIKI:PIK3R2 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) HUGO:PIK3R3 HGNC:8981 ENTREZ:8503 UNIPROT:Q92569 GENECARDS:PIK3R3 REACTOME:61182 KEGG:8503 ATLASONC:GC_PIK3R3 WIKI:PIK3R3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 PMID:19568798 PMID:12040186 References_end</body> </html> </notes> <label text="p85*"/> <bbox w="80.0" h="40.0" x="6690.0" y="488.75"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s45_akt1_akt1_sa389"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Full protein name Identifiers_begin: Phosphoinositide-3-kinase catalytic subunit p110 HUGO:PIK3CD HGNC:8977 ENTREZ:5293 UNIPROT:O00329 Identifiers_end Maps_Modules_begin: MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 Three genes ??? PIK3CA, PIK3CB and PIK3CD ??? encode the highly homologous p110 catalytic subunit isoforms p110??, p110?? and p110??, respectively101. They possess an N-terminal p85-binding domain that interacts with the p85 regulatory subunit, a Ras-binding domain (RBD) that mediates activation by the small GTPase Ras, a C2 domain, a phosphatidylinositol kinase homology (PIK) domain and a C-terminal catalytic domain. The PIK and catalytic domains of p110 are homologous to domains found in a family of protein kinases that includes mTOR (mammalian target of rapamycin), ATM (ataxia telangiectasia mutated), ATR (ataxia telangiectasia Rad3 related) and DNA-PK (DNA-dependent serine/threonine protein kinase), indicating that these proteins share an ancient evolutionary origin. PMID:19568798 The 110-kDa catalytic subunit consists of a catalytic lipid kinase domain, a Ras binding domain (RasB), a C2 phospholipid binding domain (protein kinase C homology domain), a helical PI kinase (PIK) domain and an N-terminal domain, which forms a tight association with the regulatory subunit. PMID:12040186 The regulatory sub- unit maintains the p110 catalytic subunit in a low-activity state in quiescent cells and mediates its activation by direct interaction with phosphotyrosine residues of activated growth factor receptors or adaptor proteins. References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: phosphoinositide-3-kinase, catalytic, alpha polypeptide HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 GENECARDS:PIK3CA REACTOME:61074 KEGG:5290 ATLASONC:PIK3CAID415ch3q26 WIKI:PIK3CA phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, delta polypeptide HUGO:PIK3CD HGNC:8977 ENTREZ:5293 UNIPROT:O00329 GENECARDS:PIK3CD REACTOME:61078 KEGG:5293 ATLASONC:PIK3CDID46261ch1p36 WIKI:PIK3CD phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 References_end Identifiers_begin: phosphoinositide-3-kinase, catalytic, alpha polypeptide HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 GENECARDS:PIK3CA REACTOME:61074 KEGG:5290 ATLASONC:PIK3CAID415ch3q26 WIKI:PIK3CA phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, delta polypeptide HUGO:PIK3CD HGNC:8977 ENTREZ:5293 UNIPROT:O00329 GENECARDS:PIK3CD REACTOME:61078 KEGG:5293 ATLASONC:PIK3CDID46261ch1p36 WIKI:PIK3CD phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 References_end</body> </html> </notes> <label text="p110*"/> <bbox w="80.0" h="40.0" x="6690.0" y="531.0"/> <glyph class="state variable" id="_c2a476a1-10cf-4bd9-bef6-331bfa3f4b83"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6685.0" y="546.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s47_akt1_akt1_sa390"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: GRB2-associated binding protein 1 HUGO:GAB1 HGNC:4066 ENTREZ:2549 UNIPROT:Q13480 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: GRB2-associated binding protein 1 HUGO:GAB1 HGNC:4066 ENTREZ:2549 UNIPROT:Q13480 GENECARDS:GAB1 REACTOME:147726 ATLASONC:GC_GAB1 WIKI:GAB1 GRB2-associated binding protein 2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11313945 PMID:11940581 References_end</body> </html> </notes> <label text="GAB1"/> <bbox w="80.0" h="40.0" x="6690.0" y="446.5"/> <glyph class="state variable" id="_d0a1b6a2-976d-461e-ae23-e278103efeef"> <state value="" variable="Y977"/> <bbox w="30.0" h="10.0" x="6675.4927" y="441.5"/> </glyph> <glyph class="state variable" id="_2b4e614e-c07a-46f4-ab4e-0e804b62d705"> <state value="" variable="Y989"/> <bbox w="30.0" h="10.0" x="6755.0" y="441.71478"/> </glyph> <glyph class="state variable" id="_994418de-00bf-43f6-a691-c896ed71ffa0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6685.0" y="461.5"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s52_akt1_akt1_sa391"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 References_end Identifiers_begin: son of sevenless homolog 1 (Drosophila) GINGF "gingival fibromatosis hereditary 1" HUGO:SOS1 HGNC:11187 ENTREZ:6654 UNIPROT:Q07889 GENECARDS:SOS1 REACTOME:64848 KEGG:6654 ATLASONC:GC_SOS1 WIKI:SOS1 son of sevenless homolog 2 (Drosophila) "son of sevenless (Drosophilia) homolog 2" HUGO:SOS2 HGNC:11188 ENTREZ:6655 UNIPROT:Q07890 GENECARDS:SOS2 REACTOME:64850 ATLASONC:GC_SOS2 WIKI:SOS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 PMID:15574420 PMID:11777939 References_end</body> </html> </notes> <label text="SOS*"/> <bbox w="80.0" h="40.0" x="6608.0" y="488.75"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s54_akt1_akt1_sa392"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> </notes> <label text="RAS*"/> <bbox w="80.0" h="40.0" x="6609.0" y="531.0"/> <glyph class="state variable" id="_eac7d259-8f26-465d-bab6-94864d5b609f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6604.0" y="546.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="akt1_akt1_s594_akt1_akt1_sa395"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> </notes> <label text="RTK*"/> <bbox w="90.0" h="139.0" x="6516.0454" y="391.45456"/> <glyph class="unit of information" id="_45eae6e0-7ba8-4a71-9546-9c7078096693"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="6551.0454" y="386.45456"/> </glyph> <glyph class="state variable" id="_ad4839dc-acdf-4adc-9706-da573999489f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6601.0454" y="484.7424"/> </glyph> <glyph class="state variable" id="_5d1a2f2a-0ad4-464e-9729-bd0267cdb793"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="6598.5454" y="484.7424"/> </glyph> <glyph class="state variable" id="_cbaf9d85-8f39-438f-a917-d156c54ddda7"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="6598.5454" y="455.95456"/> </glyph> <glyph class="unit of information" id="_e8b2f5bf-6c24-4d59-8c82-25d08e9c7f98"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="6538.5454" y="386.45456"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s595_akt1_akt1_csa68" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:PRAS40* Identifiers_end</body> </html> </notes> <label text="14-3-3*:PRAS40*"/> <bbox w="188.0" h="93.0" x="5871.5" y="2361.5"/> <glyph class="macromolecule" id="akt1_akt1_s596_akt1_akt1_sa396"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="5879.0" y="2382.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s597_akt1_akt1_sa397"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: AKT1 substrate 1 (proline-rich) HUGO:AKT1S1 HGNC:28426 ENTREZ:84335 UNIPROT:Q96B36 GENECARDS:AKT1S1 REACTOME:200146 KEGG:84335 ATLASONC:GC_AKT1S1 WIKI:AKT1S1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18372248 PMID:17604271 References_end</body> </html> </notes> <label text="PRAS40*"/> <bbox w="80.0" h="40.0" x="5967.0" y="2380.5"/> <glyph class="state variable" id="_97c84935-19ad-4481-89fa-336197f884ed"> <state value="P" variable="S183"/> <bbox w="35.0" h="10.0" x="5949.9927" y="2375.5"/> </glyph> <glyph class="state variable" id="_02353fc8-0590-4558-8845-2792bad3adf0"> <state value="P" variable="T246"/> <bbox w="35.0" h="10.0" x="5949.5" y="2411.6206"/> </glyph> <glyph class="state variable" id="_d334acfd-2252-428f-9429-8ba3333ee6a4"> <state value="P" variable="S212"/> <bbox w="35.0" h="10.0" x="6029.5" y="2376.491"/> </glyph> <glyph class="state variable" id="_d61e8e90-84a0-48d6-84c1-9f5ec03a278b"> <state value="P" variable="S221"/> <bbox w="35.0" h="10.0" x="6029.5" y="2414.6306"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s640_akt1_akt1_csa71" compartmentRef="akt1_akt1_c3_akt1_akt1_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:TSC2 Identifiers_end References_begin: s_akt1_re169(MAP:survival): PMID:16636147 Phosphorylation of S939 and S981 by Akt initiates binding of 14-3-3 protein to TSC2 leading to trans References_end</body> </html> </notes> <label text="14-3-3*:TSC2"/> <bbox w="103.0" h="127.0" x="6555.0" y="1332.0"/> <glyph class="macromolecule" id="akt1_akt1_s641_akt1_akt1_sa431"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 GENECARDS:TSC2 REACTOME:404219 KEGG:7249 ATLASONC:TSC2ID184 WIKI:TSC2 P49815 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 GENECARDS:TSC2 REACTOME:404219 KEGG:7249 ATLASONC:TSC2ID184 WIKI:TSC2 P49815 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end</body> </html> </notes> <label text="TSC2"/> <bbox w="80.0" h="40.0" x="6563.8823" y="1345.2941"/> <glyph class="state variable" id="_a11e8ce6-fb03-4df2-a402-d7843ffb54e9"> <state value="P" variable="S1086"/> <bbox w="40.0" h="10.0" x="6623.8823" y="1361.7604"/> </glyph> <glyph class="state variable" id="_cef4d79d-9856-4566-8291-59969bb0021b"> <state value="P" variable="S981"/> <bbox w="35.0" h="10.0" x="6622.9644" y="1340.2941"/> </glyph> <glyph class="state variable" id="_ef088f44-8b28-43e2-be9f-6ff12f6bb21a"> <state value="P" variable="S1130"/> <bbox w="40.0" h="10.0" x="6581.7847" y="1380.2941"/> </glyph> <glyph class="state variable" id="_6243d9ee-da35-4e7c-991b-7915047e6cb7"> <state value="P" variable="T1462"/> <bbox w="40.0" h="10.0" x="6544.375" y="1340.2941"/> </glyph> <glyph class="state variable" id="_82cf4a41-bcb4-4efc-b5b5-25a749e39d39"> <state value="P" variable="S1132"/> <bbox w="40.0" h="10.0" x="6543.8823" y="1379.2426"/> </glyph> <glyph class="state variable" id="_f951c6b3-92ae-4027-9315-ac5cee724817"> <state value="P" variable="S939"/> <bbox w="35.0" h="10.0" x="6584.4126" y="1340.2941"/> </glyph> <glyph class="state variable" id="_18e10ff7-ed7d-4508-8074-d376763ca64e"> <state value="P" variable="S1088"/> <bbox w="40.0" h="10.0" x="6623.264" y="1380.2941"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s639_akt1_akt1_sa432"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="6563.8823" y="1395.2941"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s642_akt1_akt1_csa72" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:TSC2 Identifiers_end References_begin: s_akt1_re168(MAP:survival): PMID:16636147 Phosphorylation of S939 and S981 by Akt initiates binding of 14-3-3 protein to TSC2 leading to trans References_end</body> </html> </notes> <label text="14-3-3*:TSC2"/> <bbox w="98.0" h="131.0" x="6712.0" y="1337.0"/> <glyph class="macromolecule" id="akt1_akt1_s635_akt1_akt1_sa428"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 GENECARDS:TSC2 REACTOME:404219 KEGG:7249 ATLASONC:TSC2ID184 WIKI:TSC2 P49815 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 GENECARDS:TSC2 REACTOME:404219 KEGG:7249 ATLASONC:TSC2ID184 WIKI:TSC2 P49815 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end</body> </html> </notes> <label text="TSC2"/> <bbox w="80.0" h="40.0" x="6719.8823" y="1353.5555"/> <glyph class="state variable" id="_4d3fa173-19bd-415e-b5f6-f513460fbcb7"> <state value="P" variable="S1086"/> <bbox w="40.0" h="10.0" x="6779.8823" y="1370.0219"/> </glyph> <glyph class="state variable" id="_9df8a908-cdd8-418b-b9b5-ef0c4ea1e98b"> <state value="P" variable="S981"/> <bbox w="35.0" h="10.0" x="6778.9644" y="1348.5555"/> </glyph> <glyph class="state variable" id="_af74a7cc-b3e6-495f-ab90-b981625b0b7e"> <state value="P" variable="S1130"/> <bbox w="40.0" h="10.0" x="6737.7847" y="1388.5555"/> </glyph> <glyph class="state variable" id="_381295cf-145b-4430-b4bf-07c5c68bbe11"> <state value="P" variable="T1462"/> <bbox w="40.0" h="10.0" x="6700.375" y="1348.5555"/> </glyph> <glyph class="state variable" id="_5ba8715e-08ec-4b67-b40b-2b4be7254996"> <state value="P" variable="S1132"/> <bbox w="40.0" h="10.0" x="6699.8823" y="1387.504"/> </glyph> <glyph class="state variable" id="_247f61de-bfb0-4ddd-a78e-0c0f7e91b0eb"> <state value="P" variable="S939"/> <bbox w="35.0" h="10.0" x="6740.4126" y="1348.5555"/> </glyph> <glyph class="state variable" id="_985b7164-33bb-4a84-a5e5-f17280896fd0"> <state value="P" variable="S1088"/> <bbox w="40.0" h="10.0" x="6779.264" y="1388.5555"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s643_akt1_akt1_sa430"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="6720.8823" y="1403.5883"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s713_akt1_akt1_csa55" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:FOXO3 Identifiers_end</body> </html> </notes> <label text="14-3-3*:FOXO3"/> <bbox w="100.0" h="120.0" x="5442.5" y="827.0"/> <glyph class="macromolecule" id="akt1_akt1_s480_akt1_akt1_sa323"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 GENECARDS:FOXO3 REACTOME:199273 KEGG:2309 ATLASONC:AF6q21ID125 WIKI:FOXO3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16288288 PMID:17646672 References_end</body> </html> </notes> <label text="FOXO3"/> <bbox w="80.0" h="40.0" x="5454.5" y="838.0"/> <glyph class="state variable" id="_1b3f3c9d-e80e-4f4e-a16f-6ec1f78310e3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5489.5" y="833.0"/> </glyph> <glyph class="state variable" id="_1c14d606-b4d4-44eb-9b80-109a23a51ac8"> <state value="" variable="S644"/> <bbox w="30.0" h="10.0" x="5439.5" y="872.7223"/> </glyph> <glyph class="state variable" id="_be5046f9-e1f8-41e6-a3be-de95280cacad"> <state value="P" variable="T32"/> <bbox w="30.0" h="10.0" x="5439.5" y="833.93024"/> </glyph> <glyph class="state variable" id="_20dcbe63-3a76-4d10-94c9-1d2e04c4b604"> <state value="P" variable="S253"/> <bbox w="35.0" h="10.0" x="5517.0" y="872.1307"/> </glyph> <glyph class="state variable" id="_75338144-caf0-47e2-a71a-7892b25b7c07"> <state value="P" variable="S315"/> <bbox w="35.0" h="10.0" x="5513.582" y="833.0"/> </glyph> <glyph class="state variable" id="_c7f61fd9-bc62-4991-aa4b-683070840be2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5449.5" y="853.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s481_akt1_akt1_sa324"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="5454.0" y="883.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s718_akt1_akt1_csa75" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APAF1:Caspase9* Identifiers_end References_begin: s_akt1_re178(MAP:survival): PMID:19788417 PMID:16977332 References_end</body> </html> </notes> <label text="APAF1:Caspase9*"/> <bbox w="102.0" h="118.0" x="5919.0" y="905.0"/> <glyph class="macromolecule" id="akt1_akt1_s719_akt1_akt1_sa475"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: caspase 9 apoptosis-related cysteine peptidase "caspase 9 apoptosis-related cysteine protease" HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Caspase9 is phosphorylated on Thr125 in a MEK1/2-dependent manner in vivo. Furthermore caspase9 is efficiently phosphorylated on Thr125 by ERK in vitro suggesting that it is targeted directly by ERK in vivo. This is one of the ways ERK plays its anti-apoptotic role. PMID:12792650 References_end Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 GENECARDS:CASP9 REACTOME:57034 KEGG:842 ATLASONC:CASP9ID423ch1p36 WIKI:CASP9 "caspase 9 apoptosis-related cysteine protease" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19788417 PMID:16977332 Caspase9 is phosphorylated on Thr125 in a MEK1/2-dependent manner in vivo. Furthermore caspase9 is efficiently phosphorylated on Thr125 by ERK in vitro suggesting that it is targeted directly by ERK in vivo. This is one of the ways ERK plays its anti-apoptotic role. PMID:12792650 References_end</body> </html> Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 GENECARDS:CASP9 REACTOME:57034 KEGG:842 ATLASONC:CASP9ID423ch1p36 WIKI:CASP9 "caspase 9 apoptosis-related cysteine protease" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19788417 PMID:16977332 Caspase9 is phosphorylated on Thr125 in a MEK1/2-dependent manner in vivo. Furthermore caspase9 is efficiently phosphorylated on Thr125 by ERK in vitro suggesting that it is targeted directly by ERK in vivo. This is one of the ways ERK plays its anti-apoptotic role. PMID:12792650 References_end</body> </html> </notes> <label text="Caspase9*"/> <bbox w="80.0" h="40.0" x="5928.5" y="958.0"/> <glyph class="state variable" id="_544cfee8-3520-43ed-9e7c-d00108a1c6df"> <state value="" variable="S196"/> <bbox w="30.0" h="10.0" x="5993.5" y="953.99097"/> </glyph> <glyph class="state variable" id="_0abc43da-374f-4cc3-af45-c02054143559"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5923.5" y="973.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s720_akt1_akt1_sa476"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: apoptotic peptidase activating factor 1 HUGO:APAF1 HGNC:576 ENTREZ:317 UNIPROT:O14727 GENECARDS:APAF1 REACTOME:50100 KEGG:317 ATLASONC:APAF1ID422 WIKI:APAF1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19788417 PMID:16977332 References_end</body> </html> </notes> <label text="APAF1"/> <bbox w="80.0" h="40.0" x="5927.5" y="914.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s724_akt1_akt1_csa76" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PAM*:TSC2 Identifiers_end References_begin: s_akt1_re180:(MAP:survival) PMID:18308511 References_end</body> </html> </notes> <label text="PAM*:TSC2"/> <bbox w="100.0" h="120.0" x="5647.0" y="1248.0"/> <glyph class="macromolecule" id="akt1_akt1_s726_akt1_akt1_sa480"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MYC binding protein 2 HUGO:MYCBP2 HGNC:23386 ENTREZ:23077 UNIPROT:O75592 GENECARDS:MYCBP2 KEGG:23077 WIKI:MYCBP2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18308511 References_end</body> </html> </notes> <label text="PAM*"/> <bbox w="80.0" h="40.0" x="5656.0" y="1256.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s728_akt1_akt1_sa482"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 GENECARDS:TSC2 REACTOME:404219 KEGG:7249 ATLASONC:TSC2ID184 WIKI:TSC2 P49815 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 GENECARDS:TSC2 REACTOME:404219 KEGG:7249 ATLASONC:TSC2ID184 WIKI:TSC2 P49815 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end</body> </html> </notes> <label text="TSC2"/> <bbox w="80.0" h="40.0" x="5654.0" y="1306.0"/> <glyph class="state variable" id="_f7840a28-6bdb-405c-9970-e453aec45484"> <state value="" variable="S1086"/> <bbox w="35.0" h="10.0" x="5716.5" y="1322.4663"/> </glyph> <glyph class="state variable" id="_48e508aa-3a74-48c7-93ec-6c17f210fdd6"> <state value="" variable="S981"/> <bbox w="30.0" h="10.0" x="5715.582" y="1301.0"/> </glyph> <glyph class="state variable" id="_5d91d894-41c6-4f63-b502-2c1f92530191"> <state value="" variable="S1130"/> <bbox w="35.0" h="10.0" x="5674.4023" y="1341.0"/> </glyph> <glyph class="state variable" id="_6b495357-9f6f-483c-afed-672d70de4590"> <state value="" variable="T1462"/> <bbox w="35.0" h="10.0" x="5636.9927" y="1301.0"/> </glyph> <glyph class="state variable" id="_2f329996-2db8-4b0b-af69-8d7379f8f8e7"> <state value="" variable="S1132"/> <bbox w="35.0" h="10.0" x="5636.5" y="1339.9485"/> </glyph> <glyph class="state variable" id="_210bb2cb-90ad-47e2-8f2f-ad9fcca88ee8"> <state value="" variable="S939"/> <bbox w="30.0" h="10.0" x="5677.0303" y="1301.0"/> </glyph> <glyph class="state variable" id="_10e06154-6a6e-4370-a382-d4afa57e5c81"> <state value="" variable="S1088"/> <bbox w="35.0" h="10.0" x="5715.882" y="1341.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s725_akt1_akt1_csa77" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:E3*:TSC2 Identifiers_end References_begin: s_akt1_re181:(MAP:survival) PMID:18298802 References_end</body> </html> </notes> <label text="E3*:TSC2"/> <bbox w="100.0" h="120.0" x="5647.0" y="1378.0"/> <glyph class="macromolecule" id="akt1_akt1_s727_akt1_akt1_sa481"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 GENECARDS:TSC2 REACTOME:404219 KEGG:7249 ATLASONC:TSC2ID184 WIKI:TSC2 P49815 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 GENECARDS:TSC2 REACTOME:404219 KEGG:7249 ATLASONC:TSC2ID184 WIKI:TSC2 P49815 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end</body> </html> </notes> <label text="TSC2"/> <bbox w="80.0" h="40.0" x="5657.0" y="1431.0"/> <glyph class="state variable" id="_d160e957-9acb-4c82-af66-77555ca5863c"> <state value="" variable="S1086"/> <bbox w="35.0" h="10.0" x="5719.5" y="1447.4663"/> </glyph> <glyph class="state variable" id="_ddb84d9e-dd20-41b9-987b-21f116ee7365"> <state value="" variable="S981"/> <bbox w="30.0" h="10.0" x="5718.582" y="1426.0"/> </glyph> <glyph class="state variable" id="_7788a771-8ffc-4aae-a5fd-73b9b60a7680"> <state value="" variable="S1130"/> <bbox w="35.0" h="10.0" x="5677.4023" y="1466.0"/> </glyph> <glyph class="state variable" id="_faa35de4-9c6f-48a5-93f8-5831ba0b4fe5"> <state value="" variable="T1462"/> <bbox w="35.0" h="10.0" x="5639.9927" y="1426.0"/> </glyph> <glyph class="state variable" id="_0817e1a6-7411-4d7d-b45c-2a7af15ff306"> <state value="" variable="S1132"/> <bbox w="35.0" h="10.0" x="5639.5" y="1464.9485"/> </glyph> <glyph class="state variable" id="_f56cff32-a100-48a4-a58d-ae2026325abe"> <state value="" variable="S939"/> <bbox w="30.0" h="10.0" x="5680.0303" y="1426.0"/> </glyph> <glyph class="state variable" id="_5b885547-b704-45b3-b6a1-355e2469cf5e"> <state value="" variable="S1088"/> <bbox w="35.0" h="10.0" x="5718.882" y="1466.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s729_akt1_akt1_sa483"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Ubiquitin protein ligase E3A HUGO:UBE3A HGNC:12496 ENTREZ:7337 UNIPROT:Q05086 GENECARDS:UBE3A REACTOME:66940 KEGG:7337 ATLASONC:UBE3AID42756ch15q11 WIKI:UBE3A ubiquitin protein ligase E3B HUGO:UBE3B HGNC:13478 ENTREZ:89910 UNIPROT:Q7Z3V4 GENECARDS:UBE3B REACTOME:253549 ATLASONC:GC_UBE3B WIKI:UBE3B ubiquitin protein ligase E3C HUGO:UBE3C HGNC:16803 ENTREZ:9690 UNIPROT:Q15386 GENECARDS:UBE3C REACTOME:253553 KEGG:9690 ATLASONC:GC_UBE3C WIKI:UBE3C ubiquitin protein ligase E3D HUGO:UBE3D HGNC:21381 ENTREZ:90025 UNIPROT:Q7Z6J8 GENECARDS:UBE3D KEGG:90025 WIKI:UBE3D Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16925947 Ubiquitin protein ligase PMID:18298802 References_end Identifiers_begin: Ubiquitin protein ligase E3A HUGO:UBE3A HGNC:12496 ENTREZ:7337 UNIPROT:Q05086 GENECARDS:UBE3A REACTOME:66940 KEGG:7337 ATLASONC:UBE3AID42756ch15q11 WIKI:UBE3A ubiquitin protein ligase E3B HUGO:UBE3B HGNC:13478 ENTREZ:89910 UNIPROT:Q7Z3V4 GENECARDS:UBE3B REACTOME:253549 ATLASONC:GC_UBE3B WIKI:UBE3B ubiquitin protein ligase E3C HUGO:UBE3C HGNC:16803 ENTREZ:9690 UNIPROT:Q15386 GENECARDS:UBE3C REACTOME:253553 KEGG:9690 ATLASONC:GC_UBE3C WIKI:UBE3C ubiquitin protein ligase E3D HUGO:UBE3D HGNC:21381 ENTREZ:90025 UNIPROT:Q7Z6J8 GENECARDS:UBE3D KEGG:90025 WIKI:UBE3D Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16925947 Ubiquitin protein ligase PMID:18298802 References_end</body> </html> </notes> <label text="E3*"/> <bbox w="80.0" h="40.0" x="5654.0" y="1383.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s730_akt1_akt1_csa78" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CUL4*:DCAF*:FBW5*:RBX1:TSC2 Identifiers_end References_begin: s_akt1_re182:(MAP:survival) PMID:18381890 References_end</body> </html> </notes> <label text="CUL4*:DCAF*:FBW5*:RBX1:TSC2"/> <bbox w="182.0" h="165.0" x="5811.0" y="1308.0"/> <glyph class="macromolecule" id="akt1_akt1_s731_akt1_akt1_sa484"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: F-box and WD repeat domain containing 5 HUGO:FBXW5 HGNC:13613 ENTREZ:54461 UNIPROT:Q969U6 GENECARDS:FBXW5 REACTOME:147217 KEGG:54461 WIKI:FBXW5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18381890 References_end</body> </html> </notes> <label text="FBW5*"/> <bbox w="80.0" h="40.0" x="5822.0" y="1360.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s732_akt1_akt1_sa485"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DDB1 and CUL4 associated factor 4 HUGO:DCAF4 HGNC:20229 ENTREZ:26094 UNIPROT:Q8WV16 GENECARDS:DCAF4 KEGG:26094 WIKI:DCAF4 DDB1 and CUL4 associated factor 5 HUGO:DCAF5 HGNC:20224 ENTREZ:8816 UNIPROT:Q96JK2 GENECARDS:DCAF5 KEGG:8816 ATLASONC:GC_DCAF5 WIKI:DCAF5 DDB1 and CUL4 associated factor 6 HUGO:DCAF6 HGNC:30002 ENTREZ:55827 UNIPROT:Q58WW2 GENECARDS:DCAF6 KEGG:55827 ATLASONC:GC_DCAF6 WIKI:DCAF6 DDB1 and CUL4 associated factor 7 HUGO:DCAF7 HGNC:30915 ENTREZ:10238 UNIPROT:P61962 GENECARDS:DCAF7 KEGG:10238 ATLASONC:GC_DCAF7 WIKI:DCAF7 DDB1 and CUL4 associated factor 8 HUGO:DCAF8 HGNC:24891 ENTREZ:50717 UNIPROT:Q5TAQ9 GENECARDS:DCAF8 KEGG:50717 WIKI:DCAF8 DDB1 and CUL4 associated factor 10 HUGO:DCAF10 HGNC:23686 ENTREZ:79269 UNIPROT:Q5QP82 GENECARDS:DCAF10 KEGG:79269 WIKI:DCAF10 DDB1 and CUL4 associated factor 11 HUGO:DCAF11 HGNC:20258 ENTREZ:80344 UNIPROT:Q8TEB1 GENECARDS:DCAF11 KEGG:80344 WIKI:DCAF11 DDB1 and CUL4 associated factor 12 HUGO:DCAF12 HGNC:19911 ENTREZ:25853 UNIPROT:Q5T6F0 GENECARDS:DCAF12 KEGG:25853 ATLASONC:GC_DCAF12 WIKI:DCAF12 DDB1 and CUL4 associated factor 13 HUGO:DCAF13 HGNC:24535 ENTREZ:25879 UNIPROT:Q9NV06 GENECARDS:DCAF13 KEGG:25879 ATLASONC:GC_DCAF13 WIKI:DCAF13 DDB1 and CUL4 associated factor 15 HUGO:DCAF15 HGNC:25095 ENTREZ:90379 UNIPROT:Q66K64 GENECARDS:DCAF15 KEGG:90379 WIKI:DCAF15 DDB1 and CUL4 associated factor 16 HUGO:DCAF16 HGNC:25987 ENTREZ:54876 UNIPROT:Q9NXF7 GENECARDS:DCAF16 KEGG:54876 WIKI:DCAF16 DDB1 and CUL4 associated factor 17 HUGO:DCAF17 HGNC:25784 ENTREZ:80067 UNIPROT:Q5H9S7 GENECARDS:DCAF17 KEGG:80067 WIKI:DCAF17 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18381890 PMID:19440234 References_end</body> </html> </notes> <label text="DCAF*"/> <bbox w="80.0" h="40.0" x="5820.0" y="1403.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s733_akt1_akt1_sa486"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> </notes> <label text="RBX1"/> <bbox w="80.0" h="40.0" x="5902.0" y="1359.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s734_akt1_akt1_sa487"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 GENECARDS:TSC2 REACTOME:404219 KEGG:7249 ATLASONC:TSC2ID184 WIKI:TSC2 P49815 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 GENECARDS:TSC2 REACTOME:404219 KEGG:7249 ATLASONC:TSC2ID184 WIKI:TSC2 P49815 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end</body> </html> </notes> <label text="TSC2"/> <bbox w="80.0" h="40.0" x="5901.0" y="1404.0"/> <glyph class="state variable" id="_60d28427-e4df-4b9c-9d13-0d93f60542fc"> <state value="" variable="S1086"/> <bbox w="35.0" h="10.0" x="5963.5" y="1420.4663"/> </glyph> <glyph class="state variable" id="_92865c47-5c7c-40a6-8761-fcf1e1998277"> <state value="" variable="S981"/> <bbox w="30.0" h="10.0" x="5962.582" y="1399.0"/> </glyph> <glyph class="state variable" id="_d642bde5-0fcb-4354-9168-d923a762bc23"> <state value="" variable="S1130"/> <bbox w="35.0" h="10.0" x="5921.4023" y="1439.0"/> </glyph> <glyph class="state variable" id="_c0a3096b-2ae8-434f-baaa-369257053af7"> <state value="" variable="T1462"/> <bbox w="35.0" h="10.0" x="5883.9927" y="1399.0"/> </glyph> <glyph class="state variable" id="_c4065c62-414e-4692-9095-1cd59dfc9d44"> <state value="" variable="S1132"/> <bbox w="35.0" h="10.0" x="5883.5" y="1437.9485"/> </glyph> <glyph class="state variable" id="_5e5bc356-421d-4b28-9c06-9477c78ee209"> <state value="" variable="S939"/> <bbox w="30.0" h="10.0" x="5924.0303" y="1399.0"/> </glyph> <glyph class="state variable" id="_a0e13755-297f-459f-9a69-d3ce1aa4e394"> <state value="" variable="S1088"/> <bbox w="35.0" h="10.0" x="5962.882" y="1439.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s735_akt1_akt1_sa488"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cullin 4A HUGO:CUL4A HGNC:2554 ENTREZ:8451 UNIPROT:Q13619 GENECARDS:CUL4A ATLASONC:GC_CUL4A WIKI:CUL4A cullin 4B HUGO:CUL4B HGNC:2555 ENTREZ:8450 UNIPROT:Q13620 GENECARDS:CUL4B KEGG:8450 ATLASONC:GC_CUL4B WIKI:CUL4B Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:NER MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19440234 PMID:18381890 References_end</body> </html> </notes> <label text="CUL4*"/> <bbox w="80.0" h="40.0" x="5820.0" y="1316.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s736_akt1_akt1_csa79" compartmentRef="akt1_akt1_c2_akt1_akt1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK4_6*:CyclinD*:p27KIP1* Identifiers_end References_begin: s_akt1_re183(MAP:survival): PMID:18414028 PMID:9106657 References_end</body> </html> </notes> <label text="CDK4_6*:CyclinD*:p27KIP1*"/> <bbox w="102.0" h="161.0" x="5342.5" y="1309.5"/> <glyph class="macromolecule" id="akt1_akt1_s737_akt1_akt1_sa489"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 References_end</body> </html> </notes> <label text="CyclinD*"/> <bbox w="80.0" h="40.0" x="5349.0" y="1359.5"/> <glyph class="state variable" id="_69f21d93-e759-4174-86ec-30ee3f327a73"> <state value="" variable="T286"/> <bbox w="30.0" h="10.0" x="5414.0" y="1354.7147"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s738_akt1_akt1_sa490"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 4 HUGO:CDK4 HGNC:1773 ENTREZ:1019 UNIPROT:P11802 GENECARDS:CDK4 REACTOME:68329 KEGG:1019 ATLASONC:CDK4ID238ch12q14 WIKI:CDK4 cyclin-dependent kinase 6 HUGO:CDK6 HGNC:1777 ENTREZ:1021 UNIPROT:Q00534 GENECARDS:CDK6 REACTOME:68335 KEGG:1021 ATLASONC:GC_CDK6 WIKI:CDK6 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 References_end</body> </html> </notes> <label text="CDK4_6*"/> <bbox w="80.0" h="40.0" x="5348.0" y="1315.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s739_akt1_akt1_sa491"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27 Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="p27KIP1*"/> <bbox w="80.0" h="40.0" x="5351.0" y="1404.5"/> <glyph class="state variable" id="_e4b45de7-48e1-4ac0-b8d3-8c515a0fcb19"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5386.0" y="1399.5"/> </glyph> <glyph class="state variable" id="_a23afa5e-8bca-43f4-84e2-fb67a7d24114"> <state value="" variable="S157"/> <bbox w="30.0" h="10.0" x="5416.0" y="1399.5"/> </glyph> <glyph class="state variable" id="_708a4f36-e1b0-48f6-8309-f900ab1e6a35"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5386.0" y="1439.5"/> </glyph> <glyph class="state variable" id="_110bb68a-50d8-43dc-b092-00d856b2ad81"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5369.4316" y="1399.5"/> </glyph> <glyph class="state variable" id="_804634bf-248f-4aa3-8223-2b793919d496"> <state value="P" variable="S10"/> <bbox w="30.0" h="10.0" x="5336.0" y="1401.9022"/> </glyph> <glyph class="state variable" id="_711e7b49-77ef-4c71-898f-6b5997964666"> <state value="P" variable="T187"/> <bbox w="35.0" h="10.0" x="5412.882" y="1439.5"/> </glyph> <glyph class="state variable" id="_6ebe3e19-ee28-4524-aad7-e42dcca49b66"> <state value="P" variable="T157"/> <bbox w="35.0" h="10.0" x="5410.082" y="1399.5"/> </glyph> <glyph class="state variable" id="_d035f51d-73c2-47b3-b80f-52e0a2bb572e"> <state value="" variable="T198"/> <bbox w="30.0" h="10.0" x="5336.0" y="1439.2223"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s742_akt1_akt1_csa80" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CUL1:FBW7*:RBX1:SKP1 Identifiers_end References_begin: s_akt1_re184:(MAP:survival) PMID:18787170 References_end</body> </html> </notes> <label text="CUL1:FBW7*:RBX1:SKP1"/> <bbox w="170.0" h="116.0" x="5603.0" y="1912.0"/> <glyph class="macromolecule" id="akt1_akt1_s743_akt1_akt1_sa492"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> </notes> <label text="CUL1"/> <bbox w="80.0" h="40.0" x="5606.0" y="1916.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s744_akt1_akt1_sa493"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 "S-phase kinase-associated protein 1A (p19A)", SKP1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 "S-phase kinase-associated protein 1A (p19A)", SKP1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 "S-phase kinase-associated protein 1A (p19A)", SKP1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> </notes> <label text="SKP1"/> <bbox w="80.0" h="40.0" x="5690.0" y="1916.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s745_akt1_akt1_sa494"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> </notes> <label text="RBX1"/> <bbox w="80.0" h="40.0" x="5606.0" y="1960.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s746_akt1_akt1_sa495"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: F-box and WD repeat domain containing 7 HUGO:FBXW7 HGNC:16712 ENTREZ:55294 UNIPROT:Q969H0 GENECARDS:FBXW7 REACTOME:147220 KEGG:55294 ATLASONC:GC_FBXW7 WIKI:FBXW7 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:15147722 PMID:14536078 References_end</body> </html> </notes> <label text="FBW7*"/> <bbox w="80.0" h="40.0" x="5690.0" y="1960.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s755_akt1_akt1_csa82" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Caspase3*:p21CIP1* Identifiers_end References_begin: s_akt1_re189:(MAP:survival) PMID:19440234 References_end</body> </html> </notes> <label text="Caspase3*:p21CIP1*"/> <bbox w="100.0" h="120.0" x="5663.0" y="2301.0"/> <glyph class="macromolecule" id="akt1_akt1_s756_akt1_akt1_sa503"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 GENECARDS:CDKN1A REACTOME:87048 KEGG:1026 ATLASONC:CDKN1AID139 WIKI:CDKN1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:P21CIP MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19440234 PMID:12851486 References_end</body> </html> </notes> <label text="p21CIP1*"/> <bbox w="80.0" h="40.0" x="5671.5" y="2361.0"/> <glyph class="state variable" id="_7e537a8b-1b17-4157-8964-2625efb91d19"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5666.5" y="2396.0"/> </glyph> <glyph class="state variable" id="_249ec7c4-d590-476a-b4ed-e622a6ed40e8"> <state value="P" variable="T145"/> <bbox w="35.0" h="10.0" x="5654.4927" y="2356.0"/> </glyph> <glyph class="state variable" id="_cce7ceae-69c8-4cba-b57c-990777f0ae84"> <state value="" variable="T146"/> <bbox w="30.0" h="10.0" x="5696.5317" y="2356.0"/> </glyph> <glyph class="state variable" id="_b51ba772-9c4a-42af-85d4-81743aa99253"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5746.5" y="2376.4016"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s757_akt1_akt1_sa504"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: CASPASE3 cleaves KSR1 in apoptotic cells. Thus MEK is sequestered in the cytosol and its interaction with Raf and ERK is prevented. PMID:17613518 References_end Identifiers_begin: HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 GENECARDS:CASP3 REACTOME:57022 KEGG:836 ATLASONC:GC_CASP3 WIKI:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 caspase 3 apoptosis-related cysteine peptidase Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: CASPASE3 cleaves KSR1 in apoptotic cells. Thus MEK is sequestered in the cytosol and its interaction with Raf and ERK is prevented. PMID:17613518 PMID:9765224 References_end</body> </html> </notes> <label text="Caspase3*"/> <bbox w="80.0" h="40.0" x="5672.5" y="2314.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s816_akt1_akt1_csa85" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CUL1:RBX1:RICTOR Identifiers_end References_begin: s_akt1_re196:(MAP:survival) PMID:20832730 References_end</body> </html> </notes> <label text="CUL1:RBX1:RICTOR"/> <bbox w="188.0" h="125.0" x="4636.0" y="608.0"/> <glyph class="macromolecule" id="akt1_akt1_s819_akt1_akt1_sa533"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RPTOR independent companion of MTOR complex 2 HUGO:RICTOR HGNC:28611 ENTREZ:253260 UNIPROT:Q6R327 GENECARDS:RICTOR REACTOME:245693 KEGG:253260 ATLASONC:GC_RICTOR WIKI:RICTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19143635 References_end</body> </html> </notes> <label text="RICTOR"/> <bbox w="80.0" h="40.0" x="4645.25" y="621.5"/> <glyph class="state variable" id="_b4ee0a33-f387-4cbf-8ebc-658c176601c5"> <state value="" variable="T1135"/> <bbox w="35.0" h="10.0" x="4647.311" y="656.5"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s820_akt1_akt1_sa534"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> </notes> <label text="CUL1"/> <bbox w="80.0" h="40.0" x="4644.5" y="664.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s821_akt1_akt1_sa535"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> </notes> <label text="RBX1"/> <bbox w="80.0" h="40.0" x="4727.5" y="622.5"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s822_akt1_akt1_csa86" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CUL1:RBX1:RICTOR Identifiers_end References_begin: s_akt1_re198:(MAP:survival) PMID:20832730 References_end</body> </html> </notes> <label text="CUL1:RBX1:RICTOR"/> <bbox w="188.0" h="125.0" x="4898.5" y="608.0"/> <glyph class="macromolecule" id="akt1_akt1_s825_akt1_akt1_sa537"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RPTOR independent companion of MTOR complex 2 HUGO:RICTOR HGNC:28611 ENTREZ:253260 UNIPROT:Q6R327 GENECARDS:RICTOR REACTOME:245693 KEGG:253260 ATLASONC:GC_RICTOR WIKI:RICTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19143635 References_end</body> </html> </notes> <label text="RICTOR"/> <bbox w="80.0" h="40.0" x="4907.75" y="621.5"/> <glyph class="state variable" id="_af8678ca-d218-4853-adb9-13fdae2c1a87"> <state value="P" variable="T1135"/> <bbox w="40.0" h="10.0" x="4907.311" y="656.5"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s823_akt1_akt1_sa538"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> </notes> <label text="CUL1"/> <bbox w="80.0" h="40.0" x="4907.0" y="664.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s824_akt1_akt1_sa539"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> </notes> <label text="RBX1"/> <bbox w="80.0" h="40.0" x="4990.0" y="622.5"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s829_akt1_akt1_csa87" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:RICTOR Identifiers_end References_begin: s_akt1_re200:(MAP:survival) PMID:20832730 References_end</body> </html> </notes> <label text="14-3-3*:RICTOR"/> <bbox w="100.0" h="120.0" x="4567.0" y="747.0"/> <glyph class="macromolecule" id="akt1_akt1_s830_akt1_akt1_sa543"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="4578.5" y="757.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s831_akt1_akt1_sa544"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RPTOR independent companion of MTOR complex 2 HUGO:RICTOR HGNC:28611 ENTREZ:253260 UNIPROT:Q6R327 GENECARDS:RICTOR REACTOME:245693 KEGG:253260 ATLASONC:GC_RICTOR WIKI:RICTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19143635 References_end</body> </html> </notes> <label text="RICTOR"/> <bbox w="80.0" h="40.0" x="4577.25" y="802.5"/> <glyph class="state variable" id="_fc69782b-0c3d-48d8-bd64-0bbd0209c39f"> <state value="P" variable="T1135"/> <bbox w="40.0" h="10.0" x="4576.811" y="837.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s835_akt1_akt1_csa88" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATG13:FIP200*:ULK* Identifiers_end References_begin: s_akt1_re201:(MAP:survival) PMID:19225151 References_end</body> </html> </notes> <label text="ATG13:FIP200*:ULK*"/> <bbox w="120.0" h="161.0" x="6473.3574" y="2343.0"/> <glyph class="macromolecule" id="akt1_akt1_s840_akt1_akt1_sa548"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Unc-51-like kinase 1 HUGO:ULK1 HGNC:12558 ENTREZ:8408 UNIPROT:O75385 GENECARDS:ULK1 KEGG:8408 ATLASONC:GC_ULK1 WIKI:ULK1 Unc-51-like kinase 2 HUGO:ULK2 HGNC:13480 ENTREZ:9706 UNIPROT:Q8IYT8 GENECARDS:ULK2 KEGG:9706 ATLASONC:GC_ULK2 WIKI:ULK2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20056399 References_end</body> </html> </notes> <label text="ULK*"/> <bbox w="80.0" h="40.0" x="6493.7144" y="2351.0"/> <glyph class="state variable" id="_478e32ec-7078-46e0-8b93-34fd13b84002"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6568.7144" y="2346.0"/> </glyph> <glyph class="state variable" id="_e91463af-7a10-4525-8e3b-c104e8d04469"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6488.7144" y="2346.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s841_akt1_akt1_sa549"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ATG13 autophagy related homologue 13 HUGO:ATG13 HGNC:29091 ENTREZ:9776 UNIPROT:O75143 GENECARDS:ATG13 KEGG:9776 WIKI:ATG13 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19941614 References_end</body> </html> </notes> <label text="ATG13"/> <bbox w="80.0" h="40.0" x="6493.7144" y="2394.5"/> <glyph class="state variable" id="_12f26ccc-f896-4241-8278-98936e342326"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6568.7144" y="2389.5"/> </glyph> <glyph class="state variable" id="_5bef2de6-d3cc-4e19-9173-effdea65cd5c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6488.7144" y="2389.5"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s842_akt1_akt1_sa550"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RB1-inducible coiled-coil 1 HUGO:RB1CC1 HGNC:15574 ENTREZ:9821 UNIPROT:Q8TDY2 GENECARDS:RB1CC1 KEGG:9821 ATLASONC:GC_RB1CC1 WIKI:RB1CC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18036779 References_end</body> </html> </notes> <label text="FIP200*"/> <bbox w="80.0" h="40.0" x="6493.7144" y="2438.0"/> <glyph class="state variable" id="_b62bc635-dbc4-44d1-b417-2e7d76c93f24"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6488.7144" y="2433.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s847_akt1_akt1_csa90" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATG13:FIP200*:ULK* Identifiers_end References_begin: s_akt1_re202:(MAP:survival) PMID:19225151 References_end</body> </html> </notes> <label text="ATG13:FIP200*:ULK*"/> <bbox w="120.0" h="161.0" x="6654.8574" y="2343.0"/> <glyph class="macromolecule" id="akt1_akt1_s850_akt1_akt1_sa554"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Unc-51-like kinase 1 HUGO:ULK1 HGNC:12558 ENTREZ:8408 UNIPROT:O75385 GENECARDS:ULK1 KEGG:8408 ATLASONC:GC_ULK1 WIKI:ULK1 Unc-51-like kinase 2 HUGO:ULK2 HGNC:13480 ENTREZ:9706 UNIPROT:Q8IYT8 GENECARDS:ULK2 KEGG:9706 ATLASONC:GC_ULK2 WIKI:ULK2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20056399 References_end</body> </html> </notes> <label text="ULK*"/> <bbox w="80.0" h="40.0" x="6675.2144" y="2351.0"/> <glyph class="state variable" id="_435ece23-3480-4749-8f57-5704e27a0b01"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="6747.7144" y="2346.0"/> </glyph> <glyph class="state variable" id="_ae21fafa-6613-4ba6-8ab1-a100c87d659b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6670.2144" y="2346.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s848_akt1_akt1_sa555"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ATG13 autophagy related homologue 13 HUGO:ATG13 HGNC:29091 ENTREZ:9776 UNIPROT:O75143 GENECARDS:ATG13 KEGG:9776 WIKI:ATG13 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19941614 References_end</body> </html> </notes> <label text="ATG13"/> <bbox w="80.0" h="40.0" x="6675.2144" y="2394.5"/> <glyph class="state variable" id="_b622f4a5-7ac3-42c1-9a6b-83b473150cd7"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="6747.7144" y="2389.5"/> </glyph> <glyph class="state variable" id="_459f0185-4e91-4965-b7f6-ebe7c9c573bd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6670.2144" y="2389.5"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s849_akt1_akt1_sa556"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RB1-inducible coiled-coil 1 HUGO:RB1CC1 HGNC:15574 ENTREZ:9821 UNIPROT:Q8TDY2 GENECARDS:RB1CC1 KEGG:9821 ATLASONC:GC_RB1CC1 WIKI:RB1CC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18036779 References_end</body> </html> </notes> <label text="FIP200*"/> <bbox w="80.0" h="40.0" x="6675.2144" y="2438.0"/> <glyph class="state variable" id="_997ac952-fab6-4a07-a4e7-30b7f3a6ae7b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6670.2144" y="2433.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s851_akt1_akt1_csa89" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATG13:FIP200*:ULK* Identifiers_end References_begin: s_akt1_re203:(MAP:survival) PMID:19225151 References_end</body> </html> </notes> <label text="ATG13:FIP200*:ULK*"/> <bbox w="120.0" h="161.0" x="6291.8574" y="2343.0"/> <glyph class="macromolecule" id="akt1_akt1_s854_akt1_akt1_sa551"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Unc-51-like kinase 1 HUGO:ULK1 HGNC:12558 ENTREZ:8408 UNIPROT:O75385 GENECARDS:ULK1 KEGG:8408 ATLASONC:GC_ULK1 WIKI:ULK1 Unc-51-like kinase 2 HUGO:ULK2 HGNC:13480 ENTREZ:9706 UNIPROT:Q8IYT8 GENECARDS:ULK2 KEGG:9706 ATLASONC:GC_ULK2 WIKI:ULK2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20056399 References_end</body> </html> </notes> <label text="ULK*"/> <bbox w="80.0" h="40.0" x="6312.2144" y="2351.0"/> <glyph class="state variable" id="_288a256c-a3b5-4ff4-a5f2-e1fd42baa2e3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6387.2144" y="2346.0"/> </glyph> <glyph class="state variable" id="_fbbd228b-b9bf-42f5-84a0-4268f0aa10a6"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="6304.7144" y="2346.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s852_akt1_akt1_sa552"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ATG13 autophagy related homologue 13 HUGO:ATG13 HGNC:29091 ENTREZ:9776 UNIPROT:O75143 GENECARDS:ATG13 KEGG:9776 WIKI:ATG13 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19941614 References_end</body> </html> </notes> <label text="ATG13"/> <bbox w="80.0" h="40.0" x="6312.2144" y="2394.5"/> <glyph class="state variable" id="_9ad9ba71-ec23-4047-858f-105b62ba2c29"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6387.2144" y="2389.5"/> </glyph> <glyph class="state variable" id="_15bdd757-7232-4ca8-957c-f72ac9281599"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="6304.7144" y="2389.5"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s853_akt1_akt1_sa553"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RB1-inducible coiled-coil 1 HUGO:RB1CC1 HGNC:15574 ENTREZ:9821 UNIPROT:Q8TDY2 GENECARDS:RB1CC1 KEGG:9821 ATLASONC:GC_RB1CC1 WIKI:RB1CC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18036779 References_end</body> </html> </notes> <label text="FIP200*"/> <bbox w="80.0" h="40.0" x="6312.2144" y="2438.0"/> <glyph class="state variable" id="_6cabc342-4216-4740-8e98-f9da450d02c9"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="6304.7144" y="2433.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s856_akt1_akt1_csa11" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:p110*:p85* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 Class IA PI3K is a heterodimer that consists of a p85 regulatory subunit and a p110 catalytic subunit. Three genes PIK3R1 PIK3R2 and PIK3R3 encode the p85?? p85?? and p55?? isoforms of the p85 regulatory subunit respectively. The PIK3R1 gene also gives rise to two shorter isoforms p55?? and p50?? through alternative transcription-initiation sites. The class IA p85 regulatory isoforms have a common core structure consisting of a p110-binding domain (also called the inter-SH2 domain) flanked by two Src-homology 2 (SH2) domains. The two longer isoforms p85?? and p85?? also have an extended N-terminal region (dashed outline) containing an Src-homology 3 (SH3) domain and a BCR homology (BH) domain flanked by two proline-rich (P) regions. PMID:19568798 PI3-Ks can be activated through several mechanisms. The SH2 domains in the p85 regulatory subunit of class Ia PI3- Ks have a high affinity for phosphorylated tyrosine residues found in activated growth factor RTKs and binding of the regulatory subunit to this motif activates PI3-KPhosphoinositide-3-kinase class I a Identifiers_end s_akt1_re2(MAP:survival): PMID:12040186 PMID:14585353 s_akt1_re6(MAP:survival): PMID:15534002 PMID:9779982 References_end</body> </html> </notes> <label text="(PI3K)"/> <clone/> <bbox w="100.0" h="110.0" x="6353.5" y="203.0"/> <glyph class="macromolecule" id="akt1_akt1_s857_akt1_akt1_sa49"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: phosphoinositide-3-kinase, regulatory subunit 1 (alpha) HUGO:PIK3R1 HGNC:8979 ENTREZ:5295 UNIPROT:P27986 GENECARDS:PIK3R1 REACTOME:61192 KEGG:5295 ATLASONC:PIK3R1ID41717ch5q13 WIKI:PIK3R1 phosphoinositide-3-kinase, regulatory subunit 2 (beta) HUGO:PIK3R2 HGNC:8980 ENTREZ:5296 UNIPROT:O00459 GENECARDS:PIK3R2 REACTOME:61194 KEGG:5296 ATLASONC:GC_PIK3R2 WIKI:PIK3R2 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) HUGO:PIK3R3 HGNC:8981 ENTREZ:8503 UNIPROT:Q92569 GENECARDS:PIK3R3 REACTOME:61182 KEGG:8503 ATLASONC:GC_PIK3R3 WIKI:PIK3R3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 PMID:19568798 PMID:12040186 References_end Identifiers_begin: phosphoinositide-3-kinase, regulatory subunit 1 (alpha) HUGO:PIK3R1 HGNC:8979 ENTREZ:5295 UNIPROT:P27986 GENECARDS:PIK3R1 REACTOME:61192 KEGG:5295 ATLASONC:PIK3R1ID41717ch5q13 WIKI:PIK3R1 phosphoinositide-3-kinase, regulatory subunit 2 (beta) HUGO:PIK3R2 HGNC:8980 ENTREZ:5296 UNIPROT:O00459 GENECARDS:PIK3R2 REACTOME:61194 KEGG:5296 ATLASONC:GC_PIK3R2 WIKI:PIK3R2 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) HUGO:PIK3R3 HGNC:8981 ENTREZ:8503 UNIPROT:Q92569 GENECARDS:PIK3R3 REACTOME:61182 KEGG:8503 ATLASONC:GC_PIK3R3 WIKI:PIK3R3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 PMID:19568798 PMID:12040186 References_end</body> </html> </notes> <label text="p85*"/> <clone/> <bbox w="80.0" h="40.0" x="6363.5" y="213.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s858_akt1_akt1_sa50"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: phosphoinositide-3-kinase, catalytic, alpha polypeptide HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 GENECARDS:PIK3CA REACTOME:61074 KEGG:5290 ATLASONC:PIK3CAID415ch3q26 WIKI:PIK3CA phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, delta polypeptide HUGO:PIK3CD HGNC:8977 ENTREZ:5293 UNIPROT:O00329 GENECARDS:PIK3CD REACTOME:61078 KEGG:5293 ATLASONC:PIK3CDID46261ch1p36 WIKI:PIK3CD phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 References_end</body> </html> Identifiers_begin: phosphoinositide-3-kinase, catalytic, alpha polypeptide HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 GENECARDS:PIK3CA REACTOME:61074 KEGG:5290 ATLASONC:PIK3CAID415ch3q26 WIKI:PIK3CA phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, delta polypeptide HUGO:PIK3CD HGNC:8977 ENTREZ:5293 UNIPROT:O00329 GENECARDS:PIK3CD REACTOME:61078 KEGG:5293 ATLASONC:PIK3CDID46261ch1p36 WIKI:PIK3CD phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 References_end</body> </html> </notes> <label text="p110*"/> <clone/> <bbox w="80.0" h="40.0" x="6363.5" y="253.0"/> <glyph class="state variable" id="_e6a82bed-a633-4925-967f-f39f98744dd0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6358.5" y="268.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s856_akt1_akt1_csa2" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:p110*:p85* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 Class IA PI3K is a heterodimer that consists of a p85 regulatory subunit and a p110 catalytic subunit. Three genes PIK3R1 PIK3R2 and PIK3R3 encode the p85?? p85?? and p55?? isoforms of the p85 regulatory subunit respectively. The PIK3R1 gene also gives rise to two shorter isoforms p55?? and p50?? through alternative transcription-initiation sites. The class IA p85 regulatory isoforms have a common core structure consisting of a p110-binding domain (also called the inter-SH2 domain) flanked by two Src-homology 2 (SH2) domains. The two longer isoforms p85?? and p85?? also have an extended N-terminal region (dashed outline) containing an Src-homology 3 (SH3) domain and a BCR homology (BH) domain flanked by two proline-rich (P) regions. PMID:19568798 PI3-Ks can be activated through several mechanisms. The SH2 domains in the p85 regulatory subunit of class Ia PI3- Ks have a high affinity for phosphorylated tyrosine residues found in activated growth factor RTKs and binding of the regulatory subunit to this motif activates PI3-KPhosphoinositide-3-kinase class I a Identifiers_end s_akt1_re2(MAP:survival): PMID:12040186 PMID:14585353 s_akt1_re6(MAP:survival): PMID:15534002 PMID:9779982 References_end</body> </html> </notes> <label text="(PI3K)"/> <clone/> <bbox w="100.0" h="110.0" x="4418.0" y="275.0"/> <glyph class="macromolecule" id="akt1_akt1_s857_akt1_akt1_sa2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: phosphoinositide-3-kinase, regulatory subunit 1 (alpha) HUGO:PIK3R1 HGNC:8979 ENTREZ:5295 UNIPROT:P27986 GENECARDS:PIK3R1 REACTOME:61192 KEGG:5295 ATLASONC:PIK3R1ID41717ch5q13 WIKI:PIK3R1 phosphoinositide-3-kinase, regulatory subunit 2 (beta) HUGO:PIK3R2 HGNC:8980 ENTREZ:5296 UNIPROT:O00459 GENECARDS:PIK3R2 REACTOME:61194 KEGG:5296 ATLASONC:GC_PIK3R2 WIKI:PIK3R2 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) HUGO:PIK3R3 HGNC:8981 ENTREZ:8503 UNIPROT:Q92569 GENECARDS:PIK3R3 REACTOME:61182 KEGG:8503 ATLASONC:GC_PIK3R3 WIKI:PIK3R3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 PMID:19568798 PMID:12040186 References_end Identifiers_begin: phosphoinositide-3-kinase, regulatory subunit 1 (alpha) HUGO:PIK3R1 HGNC:8979 ENTREZ:5295 UNIPROT:P27986 GENECARDS:PIK3R1 REACTOME:61192 KEGG:5295 ATLASONC:PIK3R1ID41717ch5q13 WIKI:PIK3R1 phosphoinositide-3-kinase, regulatory subunit 2 (beta) HUGO:PIK3R2 HGNC:8980 ENTREZ:5296 UNIPROT:O00459 GENECARDS:PIK3R2 REACTOME:61194 KEGG:5296 ATLASONC:GC_PIK3R2 WIKI:PIK3R2 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) HUGO:PIK3R3 HGNC:8981 ENTREZ:8503 UNIPROT:Q92569 GENECARDS:PIK3R3 REACTOME:61182 KEGG:8503 ATLASONC:GC_PIK3R3 WIKI:PIK3R3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 PMID:19568798 PMID:12040186 References_end</body> </html> </notes> <label text="p85*"/> <clone/> <bbox w="80.0" h="40.0" x="4428.0" y="285.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s858_akt1_akt1_sa6"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: phosphoinositide-3-kinase, catalytic, alpha polypeptide HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 GENECARDS:PIK3CA REACTOME:61074 KEGG:5290 ATLASONC:PIK3CAID415ch3q26 WIKI:PIK3CA phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, delta polypeptide HUGO:PIK3CD HGNC:8977 ENTREZ:5293 UNIPROT:O00329 GENECARDS:PIK3CD REACTOME:61078 KEGG:5293 ATLASONC:PIK3CDID46261ch1p36 WIKI:PIK3CD phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 References_end</body> </html> Identifiers_begin: phosphoinositide-3-kinase, catalytic, alpha polypeptide HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 GENECARDS:PIK3CA REACTOME:61074 KEGG:5290 ATLASONC:PIK3CAID415ch3q26 WIKI:PIK3CA phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, delta polypeptide HUGO:PIK3CD HGNC:8977 ENTREZ:5293 UNIPROT:O00329 GENECARDS:PIK3CD REACTOME:61078 KEGG:5293 ATLASONC:PIK3CDID46261ch1p36 WIKI:PIK3CD phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 References_end</body> </html> </notes> <label text="p110*"/> <clone/> <bbox w="80.0" h="40.0" x="4428.0" y="325.0"/> <glyph class="state variable" id="_b490bf72-801b-4ea5-8431-e673d82d7ff3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4423.0" y="340.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s859_akt1_akt1_csa73" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:MAPKAP1:MLST8:MTOR:PROTOR*:RICTOR Identifiers_end</body> </html> </notes> <label text="(mTORC2)"/> <bbox w="180.0" h="153.0" x="4421.5" y="402.0"/> <glyph class="macromolecule" id="akt1_akt1_s658_akt1_akt1_sa440"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 GENECARDS:MTOR REACTOME:54978 KEGG:2475 ATLASONC:FRAP1ID40639ch1p36 WIKI:MTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19568798 PMID:17680028 PMID:21157483 References_end</body> </html> </notes> <label text="MTOR"/> <bbox w="80.0" h="40.0" x="4429.0" y="410.75"/> <glyph class="state variable" id="_a7339d9c-3b73-405e-906a-2bd94d140d2d"> <state value="" variable="S1261"/> <bbox w="35.0" h="10.0" x="4415.0347" y="405.75"/> </glyph> <glyph class="state variable" id="_5d63b9ea-a07c-4c4f-8fd2-016f1e193c4a"> <state value="" variable="T2446"/> <bbox w="35.0" h="10.0" x="4488.082" y="405.75"/> </glyph> <glyph class="state variable" id="_480f3c6d-cb3d-42fc-a7ce-776c031bde69"> <state value="" variable="S2448"/> <bbox w="35.0" h="10.0" x="4490.882" y="445.75"/> </glyph> <glyph class="state variable" id="_9f14377c-dcf5-4584-89f5-45fdbcee49e5"> <state value="" variable="S2481"/> <bbox w="35.0" h="10.0" x="4411.5" y="444.6985"/> </glyph> <glyph class="state variable" id="_525acff1-ea25-481e-9a9d-352ecd0ecfcf"> <state value="" variable="Y631"/> <bbox w="30.0" h="10.0" x="4414.0" y="425.75"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s659_akt1_akt1_sa441"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Mitogen-activated protein kinase associated protein 1 HUGO:MAPKAP1 HGNC:18752 ENTREZ:79109 UNIPROT:Q9BPZ7 GENECARDS:MAPKAP1 REACTOME:413323 KEGG:79109 ATLASONC:GC_MAPKAP1 WIKI:MAPKAP1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19143635 References_end</body> </html> </notes> <label text="MAPKAP1"/> <bbox w="80.0" h="40.0" x="4429.0" y="452.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s660_akt1_akt1_sa442"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: PROTOR HUGO:PRR5 HGNC:31682 ENTREZ:55615 UNIPROT:P85299 GENECARDS:PRR5 KEGG:55615 ATLASONC:GC_PRR5 WIKI:PRR5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17461779 References_end</body> </html> </notes> <label text="PROTOR*"/> <bbox w="80.0" h="40.0" x="4428.75" y="493.25"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s661_akt1_akt1_sa443"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MTOR associated protein LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 GENECARDS:MLST8 REACTOME:355793 KEGG:64223 WIKI:MLST8 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:12408816 References_end</body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="4511.25" y="410.75"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s662_akt1_akt1_sa444"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RPTOR independent companion of MTOR complex 2 HUGO:RICTOR HGNC:28611 ENTREZ:253260 UNIPROT:Q6R327 GENECARDS:RICTOR REACTOME:245693 KEGG:253260 ATLASONC:GC_RICTOR WIKI:RICTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19143635 References_end</body> </html> </notes> <label text="RICTOR"/> <bbox w="80.0" h="40.0" x="4512.25" y="452.0"/> <glyph class="state variable" id="_69c218e8-570e-4475-8a65-6468c606a6d4"> <state value="P" variable="T1135"/> <bbox w="40.0" h="10.0" x="4511.811" y="487.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s663_akt1_akt1_sa445"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="4511.5" y="494.5"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s860_akt1_akt1_csa51" compartmentRef="akt1_akt1_c7_akt1_akt1_ca7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:MAPKAP1:MLST8:MTOR:PROTOR*:RICTOR Identifiers_end</body> </html> </notes> <label text="(mTORC2)"/> <bbox w="179.0" h="183.0" x="4674.5" y="403.375"/> <glyph class="macromolecule" id="akt1_akt1_s696_akt1_akt1_sa286"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 GENECARDS:MTOR REACTOME:54978 KEGG:2475 ATLASONC:FRAP1ID40639ch1p36 WIKI:MTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19568798 PMID:17680028 PMID:21157483 References_end</body> </html> </notes> <label text="MTOR"/> <bbox w="80.0" h="40.0" x="4683.0" y="410.125"/> <glyph class="state variable" id="_4dc81e5a-bca9-4606-bc9a-fa49fb8e3241"> <state value="" variable="S1261"/> <bbox w="35.0" h="10.0" x="4669.0347" y="405.125"/> </glyph> <glyph class="state variable" id="_6d8367fd-427e-48cc-89d9-4ba4f9ffb8a3"> <state value="" variable="T2446"/> <bbox w="35.0" h="10.0" x="4742.082" y="405.125"/> </glyph> <glyph class="state variable" id="_96e1e043-f76a-47a0-b799-09217867c901"> <state value="" variable="S2448"/> <bbox w="35.0" h="10.0" x="4744.882" y="445.125"/> </glyph> <glyph class="state variable" id="_2aa46bf5-ec28-4b65-a288-40a4952f1788"> <state value="P" variable="S2481"/> <bbox w="40.0" h="10.0" x="4663.0" y="444.0735"/> </glyph> <glyph class="state variable" id="_e27dfdea-6ebd-4178-b429-3986e030273c"> <state value="" variable="Y631"/> <bbox w="30.0" h="10.0" x="4668.0" y="425.125"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s438_akt1_akt1_sa287"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Mitogen-activated protein kinase associated protein 1 HUGO:MAPKAP1 HGNC:18752 ENTREZ:79109 UNIPROT:Q9BPZ7 GENECARDS:MAPKAP1 REACTOME:413323 KEGG:79109 ATLASONC:GC_MAPKAP1 WIKI:MAPKAP1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19143635 References_end</body> </html> </notes> <label text="MAPKAP1"/> <bbox w="80.0" h="40.0" x="4681.0" y="453.375"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s439_akt1_akt1_sa288"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: PROTOR HUGO:PRR5 HGNC:31682 ENTREZ:55615 UNIPROT:P85299 GENECARDS:PRR5 KEGG:55615 ATLASONC:GC_PRR5 WIKI:PRR5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17461779 References_end</body> </html> </notes> <label text="PROTOR*"/> <bbox w="80.0" h="40.0" x="4681.75" y="494.625"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s440_akt1_akt1_sa289"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MTOR associated protein LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 GENECARDS:MLST8 REACTOME:355793 KEGG:64223 WIKI:MLST8 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:12408816 References_end</body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="4766.25" y="408.125"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s441_akt1_akt1_sa290"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RPTOR independent companion of MTOR complex 2 HUGO:RICTOR HGNC:28611 ENTREZ:253260 UNIPROT:Q6R327 GENECARDS:RICTOR REACTOME:245693 KEGG:253260 ATLASONC:GC_RICTOR WIKI:RICTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19143635 References_end</body> </html> </notes> <label text="RICTOR"/> <bbox w="80.0" h="40.0" x="4764.25" y="450.375"/> <glyph class="state variable" id="_56aadaa9-ab3f-40b1-a059-f24e4d0cae4d"> <state value="P" variable="T1135"/> <bbox w="40.0" h="10.0" x="4763.811" y="485.375"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s442_akt1_akt1_sa292"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="4764.5" y="494.875"/> </glyph> <glyph class="macromolecule" id="akt1_s782_akt1_sa700"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re122:(MAP:survival) PMID:12514131 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <bbox w="80.0" h="40.0" x="4764.0" y="537.0"/> <glyph class="state variable" id="_8a04e358-8d9a-43dc-856e-9390f20500b0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4759.0" y="552.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s861_akt1_akt1_csa50" compartmentRef="akt1_akt1_c7_akt1_akt1_ca7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MAPKAP1:MLST8:MTOR:PROTOR*:RAC1:RICTOR Identifiers_end References_begin: s_akt1_re86:(MAP:survival) PMID:19720745 s_akt1_re21:(MAP:survival) PMID:10722653 References_end</body> </html> </notes> <label text="(mTORC2)"/> <bbox w="180.0" h="153.0" x="4888.1665" y="422.375"/> <glyph class="macromolecule" id="akt1_akt1_s695_akt1_akt1_sa281"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 GENECARDS:MTOR REACTOME:54978 KEGG:2475 ATLASONC:FRAP1ID40639ch1p36 WIKI:MTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19568798 PMID:17680028 PMID:21157483 References_end</body> </html> </notes> <label text="MTOR"/> <bbox w="80.0" h="40.0" x="4895.6665" y="431.125"/> <glyph class="state variable" id="_3f3d6de9-6272-4082-ba14-0d4a356cc6ce"> <state value="" variable="S1261"/> <bbox w="35.0" h="10.0" x="4881.701" y="426.125"/> </glyph> <glyph class="state variable" id="_7542ac59-779a-4a5e-9900-535c57ae203e"> <state value="" variable="T2446"/> <bbox w="35.0" h="10.0" x="4954.7485" y="426.125"/> </glyph> <glyph class="state variable" id="_3d29531c-ee7f-49f4-bf6e-2cb5dc963a3a"> <state value="" variable="S2448"/> <bbox w="35.0" h="10.0" x="4957.5483" y="466.125"/> </glyph> <glyph class="state variable" id="_7d2aa7a9-0697-49d1-b771-63af40e34432"> <state value="P" variable="S2481"/> <bbox w="40.0" h="10.0" x="4875.6665" y="465.0735"/> </glyph> <glyph class="state variable" id="_f99db14a-9503-456e-a987-b087ac69a7a5"> <state value="" variable="Y631"/> <bbox w="30.0" h="10.0" x="4880.6665" y="446.125"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s432_akt1_akt1_sa282"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Mitogen-activated protein kinase associated protein 1 HUGO:MAPKAP1 HGNC:18752 ENTREZ:79109 UNIPROT:Q9BPZ7 GENECARDS:MAPKAP1 REACTOME:413323 KEGG:79109 ATLASONC:GC_MAPKAP1 WIKI:MAPKAP1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19143635 References_end</body> </html> </notes> <label text="MAPKAP1"/> <bbox w="80.0" h="40.0" x="4895.6665" y="472.375"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s433_akt1_akt1_sa283"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: PROTOR HUGO:PRR5 HGNC:31682 ENTREZ:55615 UNIPROT:P85299 GENECARDS:PRR5 KEGG:55615 ATLASONC:GC_PRR5 WIKI:PRR5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17461779 References_end</body> </html> </notes> <label text="PROTOR*"/> <bbox w="80.0" h="40.0" x="4895.4165" y="513.625"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s435_akt1_akt1_sa284"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RPTOR independent companion of MTOR complex 2 HUGO:RICTOR HGNC:28611 ENTREZ:253260 UNIPROT:Q6R327 GENECARDS:RICTOR REACTOME:245693 KEGG:253260 ATLASONC:GC_RICTOR WIKI:RICTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19143635 References_end</body> </html> </notes> <label text="RICTOR"/> <bbox w="80.0" h="40.0" x="4978.9165" y="472.375"/> <glyph class="state variable" id="_9f4f037d-757d-4993-91c3-0a414d207060"> <state value="P" variable="T1135"/> <bbox w="40.0" h="10.0" x="4978.4775" y="507.375"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s434_akt1_akt1_sa285"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MTOR associated protein LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 GENECARDS:MLST8 REACTOME:355793 KEGG:64223 WIKI:MLST8 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:12408816 References_end</body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="4977.9165" y="431.125"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s811_akt1_akt1_sa530"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <bbox w="80.0" h="40.0" x="4981.5" y="516.0"/> <glyph class="state variable" id="_4e2b7831-6d87-4523-9a83-9e6dd9d45f08"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4976.5" y="531.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s862_akt1_akt1_csa16" compartmentRef="akt1_akt1_c7_akt1_akt1_ca7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MAPKAP1:MLST8:MTOR:PROTOR*:RAC1:RICTOR Identifiers_end References_begin: s_akt1_re174(MAP:survival): PMID:20027184 PMID:21474067 s_akt1_re21:(MAP:survival) PMID:10722653 s_akt1_re84(MAP:survival): PMID:20338997 PMID:18570873 PMID:18925875 s_akt1_re86:(MAP:survival) PMID:19720745 References_end</body> </html> </notes> <label text="(mTORC2)"/> <bbox w="180.0" h="153.0" x="5101.8335" y="422.375"/> <glyph class="macromolecule" id="akt1_akt1_s693_akt1_akt1_sa83"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 GENECARDS:MTOR REACTOME:54978 KEGG:2475 ATLASONC:FRAP1ID40639ch1p36 WIKI:MTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19568798 PMID:17680028 PMID:21157483 References_end</body> </html> </notes> <label text="MTOR"/> <bbox w="80.0" h="40.0" x="5109.3335" y="431.125"/> <glyph class="state variable" id="_efb5f4b6-fa82-4e80-8b2a-c0d45c1265ba"> <state value="" variable="S1261"/> <bbox w="35.0" h="10.0" x="5095.368" y="426.125"/> </glyph> <glyph class="state variable" id="_523bf0dd-1d05-43ac-a6bd-a843da6f287c"> <state value="" variable="T2446"/> <bbox w="35.0" h="10.0" x="5168.4155" y="426.125"/> </glyph> <glyph class="state variable" id="_2c55bd72-e344-425b-a9e7-1213ce3a0906"> <state value="" variable="S2448"/> <bbox w="35.0" h="10.0" x="5171.2153" y="466.125"/> </glyph> <glyph class="state variable" id="_b62e9f5c-e183-4597-b395-458f48cbe543"> <state value="P" variable="S2481"/> <bbox w="40.0" h="10.0" x="5089.3335" y="465.0735"/> </glyph> <glyph class="state variable" id="_d1772e92-f150-40db-8f06-36da7e14318a"> <state value="" variable="Y631"/> <bbox w="30.0" h="10.0" x="5094.3335" y="446.125"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s100_akt1_akt1_sa84"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Mitogen-activated protein kinase associated protein 1 HUGO:MAPKAP1 HGNC:18752 ENTREZ:79109 UNIPROT:Q9BPZ7 GENECARDS:MAPKAP1 REACTOME:413323 KEGG:79109 ATLASONC:GC_MAPKAP1 WIKI:MAPKAP1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19143635 References_end</body> </html> </notes> <label text="MAPKAP1"/> <bbox w="80.0" h="40.0" x="5109.3335" y="472.375"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s102_akt1_akt1_sa85"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: PROTOR HUGO:PRR5 HGNC:31682 ENTREZ:55615 UNIPROT:P85299 GENECARDS:PRR5 KEGG:55615 ATLASONC:GC_PRR5 WIKI:PRR5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17461779 References_end</body> </html> </notes> <label text="PROTOR*"/> <bbox w="80.0" h="40.0" x="5109.0835" y="513.625"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s103_akt1_akt1_sa86"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RPTOR independent companion of MTOR complex 2 HUGO:RICTOR HGNC:28611 ENTREZ:253260 UNIPROT:Q6R327 GENECARDS:RICTOR REACTOME:245693 KEGG:253260 ATLASONC:GC_RICTOR WIKI:RICTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19143635 References_end</body> </html> </notes> <label text="RICTOR"/> <bbox w="80.0" h="40.0" x="5192.5835" y="472.375"/> <glyph class="state variable" id="_28ae9045-aa0f-4c5d-9016-4f0bec2e23cd"> <state value="" variable="T1135"/> <bbox w="35.0" h="10.0" x="5194.6445" y="507.375"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s104_akt1_akt1_sa87"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MTOR associated protein LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 GENECARDS:MLST8 REACTOME:355793 KEGG:64223 WIKI:MLST8 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:12408816 References_end</body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="5191.5835" y="431.125"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s810_akt1_akt1_sa529"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <bbox w="80.0" h="40.0" x="5192.5" y="518.0"/> <glyph class="state variable" id="_2ac77770-58c0-447d-86a4-4e4eb032bce3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5187.5" y="533.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s863_akt1_akt1_csa58" compartmentRef="akt1_akt1_c7_akt1_akt1_ca7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DEPTOR:MAPKAP1:MLST8:MTOR:PROTOR*:RAC1:RICTOR Identifiers_end</body> </html> </notes> <label text="(mTORC2)"/> <bbox w="177.0" h="196.0" x="5315.5" y="379.375"/> <glyph class="macromolecule" id="akt1_akt1_s694_akt1_akt1_sa341"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 GENECARDS:MTOR REACTOME:54978 KEGG:2475 ATLASONC:FRAP1ID40639ch1p36 WIKI:MTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19568798 PMID:17680028 PMID:21157483 References_end</body> </html> </notes> <label text="MTOR"/> <bbox w="80.0" h="40.0" x="5323.0" y="431.125"/> <glyph class="state variable" id="_0f3beb15-a1f1-4286-a3ad-6863402de556"> <state value="" variable="S1261"/> <bbox w="35.0" h="10.0" x="5309.0347" y="426.125"/> </glyph> <glyph class="state variable" id="_ec52c0fe-adb3-4858-b456-b7651b3a81c2"> <state value="" variable="T2446"/> <bbox w="35.0" h="10.0" x="5382.082" y="426.125"/> </glyph> <glyph class="state variable" id="_ceb0697b-2878-45f6-a047-f0a5468fd60f"> <state value="" variable="S2448"/> <bbox w="35.0" h="10.0" x="5384.882" y="466.125"/> </glyph> <glyph class="state variable" id="_5e699cbc-eb0d-4d4e-b6bd-e604b248d9ff"> <state value="P" variable="S2481"/> <bbox w="40.0" h="10.0" x="5303.0" y="465.0735"/> </glyph> <glyph class="state variable" id="_cff5b5be-f876-4db7-8c1d-e789565a1be8"> <state value="" variable="Y631"/> <bbox w="30.0" h="10.0" x="5308.0" y="446.125"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s507_akt1_akt1_sa342"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Mitogen-activated protein kinase associated protein 1 HUGO:MAPKAP1 HGNC:18752 ENTREZ:79109 UNIPROT:Q9BPZ7 GENECARDS:MAPKAP1 REACTOME:413323 KEGG:79109 ATLASONC:GC_MAPKAP1 WIKI:MAPKAP1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19143635 References_end</body> </html> </notes> <label text="MAPKAP1"/> <bbox w="80.0" h="40.0" x="5323.0" y="472.375"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s508_akt1_akt1_sa343"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: PROTOR HUGO:PRR5 HGNC:31682 ENTREZ:55615 UNIPROT:P85299 GENECARDS:PRR5 KEGG:55615 ATLASONC:GC_PRR5 WIKI:PRR5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17461779 References_end</body> </html> </notes> <label text="PROTOR*"/> <bbox w="80.0" h="40.0" x="5322.75" y="513.625"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s509_akt1_akt1_sa344"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RPTOR independent companion of MTOR complex 2 HUGO:RICTOR HGNC:28611 ENTREZ:253260 UNIPROT:Q6R327 GENECARDS:RICTOR REACTOME:245693 KEGG:253260 ATLASONC:GC_RICTOR WIKI:RICTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19143635 References_end</body> </html> </notes> <label text="RICTOR"/> <bbox w="80.0" h="40.0" x="5406.25" y="472.375"/> <glyph class="state variable" id="_030920d1-f19a-402d-865a-5117bf600a20"> <state value="" variable="T1135"/> <bbox w="35.0" h="10.0" x="5408.311" y="507.375"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s510_akt1_akt1_sa345"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MTOR associated protein LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 GENECARDS:MLST8 REACTOME:355793 KEGG:64223 WIKI:MLST8 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:12408816 References_end</body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="5405.25" y="431.125"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s511_akt1_akt1_sa346"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DEP domain containing MTOR-interacting protein HUGO:DEPTOR HGNC:22953 ENTREZ:64798 UNIPROT:Q8TB45 GENECARDS:DEPTOR KEGG:64798 ATLASONC:GC_DEPTOR WIKI:DEPTOR Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19446321 PMID:19706736 References_end</body> </html> </notes> <label text="DEPTOR"/> <bbox w="80.0" h="40.0" x="5404.5" y="515.875"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s812_akt1_akt1_sa531"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <bbox w="80.0" h="40.0" x="5355.5" y="389.0"/> <glyph class="state variable" id="_1306b214-28f0-4643-a28b-512624da24a5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5350.5" y="404.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s864_akt1_akt1_csa74" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MAPKAP1:MLST8:MTOR:PROTOR*:RAC1:RICTOR Identifiers_end References_begin: s_akt1_re174(MAP:survival): PMID:20027184 PMID:21474067 References_end</body> </html> </notes> <label text="(mTORC2)"/> <bbox w="180.0" h="153.0" x="4423.5" y="576.0"/> <glyph class="macromolecule" id="akt1_akt1_s665_akt1_akt1_sa446"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 GENECARDS:MTOR REACTOME:54978 KEGG:2475 ATLASONC:FRAP1ID40639ch1p36 WIKI:MTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19568798 PMID:17680028 PMID:21157483 References_end</body> </html> </notes> <label text="MTOR"/> <bbox w="80.0" h="40.0" x="4431.0" y="584.75"/> <glyph class="state variable" id="_8d803584-b300-47f7-a52d-b94ee38fa81e"> <state value="" variable="S1261"/> <bbox w="35.0" h="10.0" x="4417.0347" y="579.75"/> </glyph> <glyph class="state variable" id="_4f789370-1145-4cee-adc8-1ab8fbe3e918"> <state value="" variable="T2446"/> <bbox w="35.0" h="10.0" x="4490.082" y="579.75"/> </glyph> <glyph class="state variable" id="_5c0e4865-460c-4529-97d2-caac2b47c133"> <state value="" variable="S2448"/> <bbox w="35.0" h="10.0" x="4492.882" y="619.75"/> </glyph> <glyph class="state variable" id="_511c29db-7064-4067-84ca-9ca389c15bfb"> <state value="" variable="S2481"/> <bbox w="35.0" h="10.0" x="4413.5" y="618.6985"/> </glyph> <glyph class="state variable" id="_261eb0c5-160b-4bd1-a399-a407a3d67ddf"> <state value="" variable="Y631"/> <bbox w="30.0" h="10.0" x="4416.0" y="599.75"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s666_akt1_akt1_sa447"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Mitogen-activated protein kinase associated protein 1 HUGO:MAPKAP1 HGNC:18752 ENTREZ:79109 UNIPROT:Q9BPZ7 GENECARDS:MAPKAP1 REACTOME:413323 KEGG:79109 ATLASONC:GC_MAPKAP1 WIKI:MAPKAP1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19143635 References_end</body> </html> </notes> <label text="MAPKAP1"/> <bbox w="80.0" h="40.0" x="4431.0" y="626.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s667_akt1_akt1_sa448"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: PROTOR HUGO:PRR5 HGNC:31682 ENTREZ:55615 UNIPROT:P85299 GENECARDS:PRR5 KEGG:55615 ATLASONC:GC_PRR5 WIKI:PRR5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17461779 References_end</body> </html> </notes> <label text="PROTOR*"/> <bbox w="80.0" h="40.0" x="4430.75" y="667.25"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s668_akt1_akt1_sa449"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RPTOR independent companion of MTOR complex 2 HUGO:RICTOR HGNC:28611 ENTREZ:253260 UNIPROT:Q6R327 GENECARDS:RICTOR REACTOME:245693 KEGG:253260 ATLASONC:GC_RICTOR WIKI:RICTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19143635 References_end</body> </html> </notes> <label text="RICTOR"/> <bbox w="80.0" h="40.0" x="4514.25" y="626.0"/> <glyph class="state variable" id="_21337492-50e9-4848-9eb3-49b847ceb083"> <state value="" variable="T1135"/> <bbox w="35.0" h="10.0" x="4516.311" y="661.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s669_akt1_akt1_sa450"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MTOR associated protein LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 GENECARDS:MLST8 REACTOME:355793 KEGG:64223 WIKI:MLST8 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:12408816 References_end</body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="4513.25" y="584.75"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s809_akt1_akt1_sa528"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <bbox w="80.0" h="40.0" x="4513.0" y="668.0"/> <glyph class="state variable" id="_8e89bd7b-8654-415b-8c51-a97552f9dddf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4508.0" y="683.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s865_akt1_akt1_csa8" compartmentRef="akt1_akt1_c7_akt1_akt1_ca7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PDPK1:PI3,4,5-P3 Identifiers_end References_begin: s_akt1_re7(MAP:survival): PMID:18802401 PMID:17680028 References_end</body> </html> </notes> <label text="(PIP3/PDK1)"/> <bbox w="88.0" h="118.0" x="5313.0" y="249.5"/> <glyph class="simple chemical" id="akt1_akt1_s37_akt1_akt1_sa34"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: phosphatidylinositol-3,4,5-triphosphate CAS:N/A PUBCHEM:8260 CHEBI:16618 KEGGCOMPOUND:C05981 Identifiers_end Maps_Modules_begin: MODULE:PI3K_AKT_MTOR Maps_Modules_end</body> </html> </notes> <label text="PI3,4,5-P3"/> <bbox w="70.0" h="25.0" x="5323.75" y="259.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s39_akt1_akt1_sa37"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: 3-phosphoinositide dependent protein kinase-1 HUGO:PDPK1 HGNC:8816 ENTREZ:5170 UNIPROT:O15530 GENECARDS:PDPK1 REACTOME:61460 KEGG:5170 ATLASONC:GC_PDPK1 WIKI:PDPK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18802401 PMID:17680028 References_end</body> </html> </notes> <label text="PDPK1"/> <bbox w="80.0" h="40.0" x="5318.5" y="292.5"/> <glyph class="state variable" id="_d4d343c2-d92b-4d6c-b037-aa29e2f2f74d"> <state value="P" variable="S241"/> <bbox w="35.0" h="10.0" x="5340.9043" y="327.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s866_akt1_akt1_csa14" compartmentRef="akt1_akt1_c7_akt1_akt1_ca7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AKT1:PI3,4,5-P3 Identifiers_end References_begin: s_akt1_re21:(MAP:survival) PMID:10722653 s_akt1_re57(MAP:survival): PMID:18372248 PMID:20138985 s_akt1_re96(MAP:survival): PMID:18570873 PMID:18636226 p27 is phosphorylated by Akt RSK1 and RSK2 in early G1 phase s_akt1_re114:(MAP:survival) PMID:17052453 s_akt1_re116:(MAP:survival) PMID:15808505 s_akt1_re118(MAP:survival): PMID:15169778 PMID:11923280 PMID:11715018 PMID:16697215 s_akt1_re123:(MAP:survival) PMID:10949026 s_akt1_re134:(MAP:survival) PMID:9812896 s_akt1_re186:(MAP:survival) PMID:11756412 s_akt1_re198:(MAP:survival) PMID:20832730 References_end</body> </html> </notes> <label text="(PIP3/AKT)"/> <bbox w="100.0" h="112.0" x="5514.0" y="459.0"/> <glyph class="macromolecule" id="akt1_akt1_s672_akt1_akt1_sa72"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:cellcycle / MODULE:CYCLIND MAP:cellcycle / MODULE:P21CIP MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:cellcycle / MODULE:CYCLIND MAP:cellcycle / MODULE:P21CIP MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end</body> </html> </notes> <label text="AKT1"/> <bbox w="80.0" h="40.0" x="5519.5" y="502.0"/> <glyph class="state variable" id="_539d1a22-52e7-4d45-9086-5d5e5119a7a7"> <state value="P" variable="T308"/> <bbox w="35.0" h="10.0" x="5502.0" y="500.77402"/> </glyph> <glyph class="state variable" id="_651ce1c7-fc00-4e66-9a5d-13c8f8cd1941"> <state value="P" variable="T450"/> <bbox w="35.0" h="10.0" x="5581.6333" y="497.0"/> </glyph> <glyph class="state variable" id="_5520c860-81fd-48e7-b4ac-07e390595f00"> <state value="P" variable="S473"/> <bbox w="35.0" h="10.0" x="5582.0" y="536.1307"/> </glyph> <glyph class="state variable" id="_3c68d801-b3fd-4bee-a34e-79f97211f7a3"> <state value="" variable="S129"/> <bbox w="30.0" h="10.0" x="5504.5" y="533.1206"/> </glyph> </glyph> <glyph class="simple chemical" id="akt1_akt1_s673_akt1_akt1_sa71"> <label text="PI3,4,5-P3"/> <bbox w="70.0" h="25.0" x="5529.5" y="468.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s867_akt1_akt1_csa13" compartmentRef="akt1_akt1_c7_akt1_akt1_ca7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AKT1:PI3,4,5-P3 Identifiers_end References_begin: s_akt1_re116:(MAP:survival) PMID:15808505 s_akt1_re21:(MAP:survival) PMID:10722653 s_akt1_re24:(MAP:survival) PMID:18042541 PMID:18077353 References_end</body> </html> </notes> <label text="(PIP3/AKT)"/> <bbox w="100.0" h="112.0" x="5511.0" y="188.5"/> <glyph class="simple chemical" id="akt1_akt1_s89_akt1_akt1_sa69"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: phosphatidylinositol-3,4,5-triphosphate CAS:N/A PUBCHEM:8260 CHEBI:16618 KEGGCOMPOUND:C05981 Identifiers_end Maps_Modules_begin: MODULE:PI3K_AKT_MTOR Maps_Modules_end</body> </html> </notes> <label text="PI3,4,5-P3"/> <bbox w="70.0" h="25.0" x="5520.5" y="194.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s90_akt1_akt1_sa70"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:cellcycle / MODULE:CYCLIND MAP:cellcycle / MODULE:P21CIP MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:cellcycle / MODULE:CYCLIND MAP:cellcycle / MODULE:P21CIP MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end</body> </html> </notes> <label text="AKT1"/> <bbox w="80.0" h="40.0" x="5524.5" y="230.5"/> <glyph class="state variable" id="_30f01c26-c2e0-4cb3-b354-b0dfe6b7212f"> <state value="P" variable="T308"/> <bbox w="35.0" h="10.0" x="5507.0" y="229.27402"/> </glyph> <glyph class="state variable" id="_8a6bc597-d174-4933-94ab-190608c79e6f"> <state value="P" variable="T450"/> <bbox w="35.0" h="10.0" x="5586.6333" y="225.5"/> </glyph> <glyph class="state variable" id="_6c6da30c-4b59-4b0b-81b4-094db9bf1177"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="5589.5" y="264.63065"/> </glyph> <glyph class="state variable" id="_a66b4248-8be6-4907-9ca5-8ee0044c5e39"> <state value="" variable="S129"/> <bbox w="30.0" h="10.0" x="5509.5" y="261.6206"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s868_akt1_akt1_csa38" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:4E-BP*:EIF3*:EIF4E*:M7GTP*:mRNA generic*:p70_alpha_* Identifiers_end References_begin: s_akt1_re65:(MAP:survival) PMID:16286006 References_end</body> </html> </notes> <label text="(eIF3/mRNA)"/> <bbox w="362.0" h="147.0" x="4476.75" y="994.0"/> <glyph class="macromolecule" id="akt1_akt1_s305_akt1_akt1_sa142"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ribosomal protein S6 kinase 70kDa polypeptide 1 "ribosomal protein S6 kinase 70kD polypeptide 1" STK14A HUGO:RPS6KB1 HGNC:10436 ENTREZ:6198 UNIPROT:P23443 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: ribosomal protein S6 kinase 70kDa polypeptide 1 "ribosomal protein S6 kinase 70kD polypeptide 1" STK14A HUGO:RPS6KB1 HGNC:10436 ENTREZ:6198 UNIPROT:P23443 GENECARDS:RPS6KB1 REACTOME:57803 KEGG:6198 ATLASONC:GC_RPS6KB1 WIKI:RPS6KB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16286006 PMID:20647036 PMID:11108711 References_end</body> </html> </notes> <label text="p70α*"/> <bbox w="80.0" h="40.0" x="4680.75" y="1039.0"/> <glyph class="state variable" id="_4587bf16-05ae-4353-9ff8-6590410d8785"> <state value="" variable="T389"/> <bbox w="30.0" h="10.0" x="4745.75" y="1071.6544"/> </glyph> <glyph class="state variable" id="_ee71c2f4-71a5-4f79-a486-cd795025933c"> <state value="" variable="T229"/> <bbox w="30.0" h="10.0" x="4665.75" y="1036.4022"/> </glyph> <glyph class="state variable" id="_743e9ea4-0966-428b-aa97-b6ac41b55864"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4675.75" y="1054.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_akt1_s306_akt1_akt1_sa205"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end</body> </html> </notes> <label text="mRNA generic*"/> <bbox w="318.0" h="29.0" x="4509.75" y="1081.5"/> <glyph class="unit of information" id="_60d66557-a951-4bf1-9ff4-9b20d0cbaba3"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4658.75" y="1076.5"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s307_akt1_akt1_sa209"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: eukaryotic translation initiation factor 4E family member 2 4EHP IF4e HUGO:EIF4E2 HGNC:3293 ENTREZ:9470 UNIPROT:O60573 GENECARDS:EIF4E2 REACTOME:92953 KEGG:9470 ATLASONC:GC_EIF4E2 WIKI:EIF4E2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17368478 References_end</body> </html> </notes> <label text="M7GTP*"/> <bbox w="49.0" h="45.0" x="4483.75" y="1079.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s308_akt1_akt1_sa210"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: eukaryotic translation initiation factor 4E HUGO:EIF4E HGNC:3287 ENTREZ:1977 UNIPROT:P06730 GENECARDS:EIF4E REACTOME:72577 KEGG:1977 ATLASONC:EIF4EID40431ch4q23 WIKI:EIF4E eukaryotic translation initiation factor 4E family member 1B HUGO:EIF4E1B HGNC:33179 ENTREZ:253314 UNIPROT:A6NMX2 GENECARDS:EIF4E1B WIKI:EIF4E1B eukaryotic translation initiation factor 4E family member 2 HUGO:EIF4E2 HGNC:3293 ENTREZ:9470 UNIPROT:O60573 GENECARDS:EIF4E2 REACTOME:92953 KEGG:9470 ATLASONC:GC_EIF4E2 WIKI:EIF4E2 eukaryotic translation initiation factor 4E family member 3 HUGO:EIF4E3 HGNC:31837 ENTREZ:317649 UNIPROT:Q8N5X7 GENECARDS:EIF4E3 REACTOME:232515 WIKI:EIF4E3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19597330 PMID:19339977 PMID:18391071 References_end</body> </html> </notes> <label text="EIF4E*"/> <bbox w="113.0" h="38.0" x="4483.75" y="1041.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s309_akt1_akt1_sa212"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: eukaryotic translation initiation factor 4E binding protein 1 HUGO:EIF4EBP1 HGNC:3288 ENTREZ:1978 UNIPROT:Q13541 GENECARDS:EIF4EBP1 REACTOME:84152 KEGG:1978 ATLASONC:EIF4EBP1ID40432ch8p12 WIKI:EIF4EBP1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19339977 PMID:15314020 PMID:12709531 References_end</body> </html> </notes> <label text="4E-BP*"/> <bbox w="80.0" h="40.0" x="4516.75" y="999.0"/> <glyph class="state variable" id="_eccf433d-0488-4d0f-96b7-061783d4a90e"> <state value="" variable="T37"/> <bbox w="25.0" h="10.0" x="4504.25" y="996.4022"/> </glyph> <glyph class="state variable" id="_5952e95c-2019-4482-a213-7cf3acdf60a2"> <state value="" variable="T46"/> <bbox w="25.0" h="10.0" x="4584.25" y="994.99097"/> </glyph> <glyph class="state variable" id="_49948444-49b2-4de3-9905-4723bb22a968"> <state value="" variable="S65"/> <bbox w="25.0" h="10.0" x="4504.25" y="1031.4851"/> </glyph> <glyph class="state variable" id="_e47e937b-cf7f-4d01-af3f-c2349c61db9d"> <state value="" variable="T70"/> <bbox w="25.0" h="10.0" x="4583.632" y="1034.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s310_akt1_akt1_sa213"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: eukaryotic translation initiation factor 3 subunit A HUGO:EIF3A HGNC:3271 ENTREZ:8661 UNIPROT:Q14152 GENECARDS:EIF3A REACTOME:72545 KEGG:3692 ATLASONC:EIF3AID40425ch10q26 WIKI:EIF3A eukaryotic translation initiation factor 3 subunit B HUGO:EIF3B HGNC:3280 ENTREZ:8662 UNIPROT:P55884 GENECARDS:EIF3B REACTOME:72541 KEGG:8662 ATLASONC:GC_EIF3B WIKI:EIF3B eukaryotic translation initiation factor 3 subunit C HUGO:EIF3C HGNC:3279 ENTREZ:8663 UNIPROT:Q99613 GENECARDS:EIF3C REACTOME:72549 KEGG:8663 ATLASONC:EIF3CID44187ch16p11 WIKI:EIF3C eukaryotic translation initiation factor 3 subunit D HUGO:EIF3D HGNC:3278 ENTREZ:8664 UNIPROT:O15371 GENECARDS:EIF3D REACTOME:72547 KEGG:8664 WIKI:EIF3D eukaryotic translation initiation factor 3 subunit E HUGO:EIF3E HGNC:3277 ENTREZ:3646 UNIPROT:P60228 GENECARDS:EIF3E REACTOME:72551 KEGG:3646 ATLASONC:GC_EIF3E WIKI:EIF3E eukaryotic translation initiation factor 3 subunit F HUGO:EIF3F HGNC:3275 ENTREZ:8665 UNIPROT:O00303 GENECARDS:EIF3F REACTOME:72539 KEGG:8665 ATLASONC:EIF3FID44407ch11p15 WIKI:EIF3F eukaryotic translation initiation factor 3 subunit G HUGO:EIF3G HGNC:3274 ENTREZ:8666 UNIPROT:O75821 GENECARDS:EIF3G REACTOME:72537 KEGG:8666 WIKI:EIF3G eukaryotic translation initiation factor 3 subunit H HUGO:EIF3H HGNC:3273 ENTREZ:8667 UNIPROT:O15372 GENECARDS:EIF3H REACTOME:72543 KEGG:8667 ATLASONC:GC_EIF3H WIKI:EIF3H eukaryotic translation initiation factor 3 subunit I HUGO:EIF3I HGNC:3272 ENTREZ:8668 UNIPROT:Q13347 GENECARDS:EIF3I REACTOME:72535 KEGG:8668 ATLASONC:GC_EIF3I WIKI:EIF3I eukaryotic translation initiation factor 3 subunit J HUGO:EIF3J HGNC:3270 ENTREZ:8669 UNIPROT:O75822 GENECARDS:EIF3J REACTOME:72533 KEGG:8669 WIKI:EIF3J eukaryotic translation initiation factor 3 subunit K HUGO:EIF3K HGNC:24656 ENTREZ:27335 UNIPROT:Q9UBQ5 GENECARDS:EIF3K REACTOME:72553 KEGG:27335 ATLASONC:GC_EIF3K WIKI:EIF3K eukaryotic translation initiation factor 3 subunit L HUGO:EIF3L HGNC:18138 ENTREZ:51386 UNIPROT:Q9Y262 GENECARDS:EIF3L KEGG:51386 WIKI:EIF3L eukaryotic translation initiation factor 3 subunit M HUGO:EIF3M HGNC:24460 ENTREZ:10480 UNIPROT:Q7L2H7 GENECARDS:EIF3M KEGG:10480 ATLASONC:GC_EIF3M WIKI:EIF3M Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16286006 PMID:20647036 References_end</body> </html> </notes> <label text="EIF3*"/> <bbox w="80.0" h="40.0" x="4598.75" y="1039.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s869_akt1_akt1_csa39" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:EIF3*:EIF4E*:M7GTP*:MLST8:MTOR:RPTOR:mRNA generic*:p70_alpha_* Identifiers_end References_begin: s_akt1_re65:(MAP:survival) PMID:16286006 References_end</body> </html> </notes> <label text="(eIF3/mRNA/mTOR)"/> <bbox w="360.0" h="233.0" x="4471.625" y="1259.5"/> <glyph class="macromolecule" id="akt1_akt1_s339_akt1_akt1_sa214"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ribosomal protein S6 kinase 70kDa polypeptide 1 "ribosomal protein S6 kinase 70kD polypeptide 1" STK14A HUGO:RPS6KB1 HGNC:10436 ENTREZ:6198 UNIPROT:P23443 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: ribosomal protein S6 kinase 70kDa polypeptide 1 "ribosomal protein S6 kinase 70kD polypeptide 1" STK14A HUGO:RPS6KB1 HGNC:10436 ENTREZ:6198 UNIPROT:P23443 GENECARDS:RPS6KB1 REACTOME:57803 KEGG:6198 ATLASONC:GC_RPS6KB1 WIKI:RPS6KB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16286006 PMID:20647036 PMID:11108711 References_end</body> </html> </notes> <label text="p70α*"/> <bbox w="80.0" h="40.0" x="4677.625" y="1380.5"/> <glyph class="state variable" id="_e0cd9511-70ae-4001-9c3f-8fc008000d69"> <state value="P" variable="T389"/> <bbox w="35.0" h="10.0" x="4740.125" y="1413.1544"/> </glyph> <glyph class="state variable" id="_9c0a8c24-d40c-4fd8-8866-ff7b8d2e0dcd"> <state value="" variable="T229"/> <bbox w="30.0" h="10.0" x="4662.625" y="1377.9022"/> </glyph> <glyph class="state variable" id="_0e39febb-5314-4ee7-b924-0365c28f87e1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4672.625" y="1395.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_akt1_s340_akt1_akt1_sa215"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end</body> </html> </notes> <label text="mRNA generic*"/> <bbox w="318.0" h="29.0" x="4506.625" y="1423.0"/> <glyph class="unit of information" id="_9d27fe6b-edf3-4e27-af04-07af49753f07"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4655.625" y="1418.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s341_akt1_akt1_sa216"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: eukaryotic translation initiation factor 4E family member 2 4EHP IF4e HUGO:EIF4E2 HGNC:3293 ENTREZ:9470 UNIPROT:O60573 GENECARDS:EIF4E2 REACTOME:92953 KEGG:9470 ATLASONC:GC_EIF4E2 WIKI:EIF4E2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17368478 References_end</body> </html> </notes> <label text="M7GTP*"/> <bbox w="49.0" h="45.0" x="4480.625" y="1420.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s342_akt1_akt1_sa217"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: eukaryotic translation initiation factor 4E HUGO:EIF4E HGNC:3287 ENTREZ:1977 UNIPROT:P06730 GENECARDS:EIF4E REACTOME:72577 KEGG:1977 ATLASONC:EIF4EID40431ch4q23 WIKI:EIF4E eukaryotic translation initiation factor 4E family member 1B HUGO:EIF4E1B HGNC:33179 ENTREZ:253314 UNIPROT:A6NMX2 GENECARDS:EIF4E1B WIKI:EIF4E1B eukaryotic translation initiation factor 4E family member 2 HUGO:EIF4E2 HGNC:3293 ENTREZ:9470 UNIPROT:O60573 GENECARDS:EIF4E2 REACTOME:92953 KEGG:9470 ATLASONC:GC_EIF4E2 WIKI:EIF4E2 eukaryotic translation initiation factor 4E family member 3 HUGO:EIF4E3 HGNC:31837 ENTREZ:317649 UNIPROT:Q8N5X7 GENECARDS:EIF4E3 REACTOME:232515 WIKI:EIF4E3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19597330 PMID:19339977 PMID:18391071 References_end</body> </html> </notes> <label text="EIF4E*"/> <bbox w="113.0" h="38.0" x="4480.625" y="1382.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s343_akt1_akt1_sa219"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: eukaryotic translation initiation factor 3 subunit A HUGO:EIF3A HGNC:3271 ENTREZ:8661 UNIPROT:Q14152 GENECARDS:EIF3A REACTOME:72545 KEGG:3692 ATLASONC:EIF3AID40425ch10q26 WIKI:EIF3A eukaryotic translation initiation factor 3 subunit B HUGO:EIF3B HGNC:3280 ENTREZ:8662 UNIPROT:P55884 GENECARDS:EIF3B REACTOME:72541 KEGG:8662 ATLASONC:GC_EIF3B WIKI:EIF3B eukaryotic translation initiation factor 3 subunit C HUGO:EIF3C HGNC:3279 ENTREZ:8663 UNIPROT:Q99613 GENECARDS:EIF3C REACTOME:72549 KEGG:8663 ATLASONC:EIF3CID44187ch16p11 WIKI:EIF3C eukaryotic translation initiation factor 3 subunit D HUGO:EIF3D HGNC:3278 ENTREZ:8664 UNIPROT:O15371 GENECARDS:EIF3D REACTOME:72547 KEGG:8664 WIKI:EIF3D eukaryotic translation initiation factor 3 subunit E HUGO:EIF3E HGNC:3277 ENTREZ:3646 UNIPROT:P60228 GENECARDS:EIF3E REACTOME:72551 KEGG:3646 ATLASONC:GC_EIF3E WIKI:EIF3E eukaryotic translation initiation factor 3 subunit F HUGO:EIF3F HGNC:3275 ENTREZ:8665 UNIPROT:O00303 GENECARDS:EIF3F REACTOME:72539 KEGG:8665 ATLASONC:EIF3FID44407ch11p15 WIKI:EIF3F eukaryotic translation initiation factor 3 subunit G HUGO:EIF3G HGNC:3274 ENTREZ:8666 UNIPROT:O75821 GENECARDS:EIF3G REACTOME:72537 KEGG:8666 WIKI:EIF3G eukaryotic translation initiation factor 3 subunit H HUGO:EIF3H HGNC:3273 ENTREZ:8667 UNIPROT:O15372 GENECARDS:EIF3H REACTOME:72543 KEGG:8667 ATLASONC:GC_EIF3H WIKI:EIF3H eukaryotic translation initiation factor 3 subunit I HUGO:EIF3I HGNC:3272 ENTREZ:8668 UNIPROT:Q13347 GENECARDS:EIF3I REACTOME:72535 KEGG:8668 ATLASONC:GC_EIF3I WIKI:EIF3I eukaryotic translation initiation factor 3 subunit J HUGO:EIF3J HGNC:3270 ENTREZ:8669 UNIPROT:O75822 GENECARDS:EIF3J REACTOME:72533 KEGG:8669 WIKI:EIF3J eukaryotic translation initiation factor 3 subunit K HUGO:EIF3K HGNC:24656 ENTREZ:27335 UNIPROT:Q9UBQ5 GENECARDS:EIF3K REACTOME:72553 KEGG:27335 ATLASONC:GC_EIF3K WIKI:EIF3K eukaryotic translation initiation factor 3 subunit L HUGO:EIF3L HGNC:18138 ENTREZ:51386 UNIPROT:Q9Y262 GENECARDS:EIF3L KEGG:51386 WIKI:EIF3L eukaryotic translation initiation factor 3 subunit M HUGO:EIF3M HGNC:24460 ENTREZ:10480 UNIPROT:Q7L2H7 GENECARDS:EIF3M KEGG:10480 ATLASONC:GC_EIF3M WIKI:EIF3M Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16286006 PMID:20647036 References_end</body> </html> </notes> <label text="EIF3*"/> <bbox w="80.0" h="40.0" x="4595.625" y="1380.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s698_akt1_akt1_sa456"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MTOR associated protein LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 GENECARDS:MLST8 REACTOME:355793 KEGG:64223 WIKI:MLST8 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:12408816 References_end</body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="4589.772" y="1276.4706"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s699_akt1_akt1_sa457"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: regulatory associated protein of MTOR complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 GENECARDS:RPTOR REACTOME:153287 KEGG:57521 ATLASONC:GC_RPTOR WIKI:RPTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19864431 PMID:12150925 PMID:15755954 References_end</body> </html> </notes> <label text="RPTOR"/> <bbox w="140.0" h="46.0" x="4673.522" y="1273.4706"/> <glyph class="state variable" id="_7c69c54e-ec71-4aa6-9998-9069980ab315"> <state value="P" variable="S696"/> <bbox w="35.0" h="10.0" x="4656.022" y="1291.434"/> </glyph> <glyph class="state variable" id="_4edf72cd-00ef-449f-aaa6-e98d3c151210"> <state value="P" variable="T706"/> <bbox w="35.0" h="10.0" x="4690.5347" y="1268.4706"/> </glyph> <glyph class="state variable" id="_b3a72078-1ed8-4b07-9dc4-c69c3372bb64"> <state value="P" variable="S855"/> <bbox w="35.0" h="10.0" x="4755.683" y="1268.4706"/> </glyph> <glyph class="state variable" id="_2b223871-21df-4a41-9fdf-d7527a952971"> <state value="P" variable="S863"/> <bbox w="35.0" h="10.0" x="4755.4204" y="1314.4706"/> </glyph> <glyph class="state variable" id="_e62dbc48-3bd7-4574-a2f6-1a86368304c6"> <state value="P" variable="S877"/> <bbox w="35.0" h="10.0" x="4692.863" y="1314.4706"/> </glyph> <glyph class="state variable" id="_e3609964-8e53-464f-bd87-c656cf709f34"> <state value="P" variable="S859"/> <bbox w="35.0" h="10.0" x="4796.022" y="1288.9303"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s700_akt1_akt1_sa458"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 GENECARDS:MTOR REACTOME:54978 KEGG:2475 ATLASONC:FRAP1ID40639ch1p36 WIKI:MTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19568798 PMID:17680028 PMID:21157483 References_end</body> </html> </notes> <label text="MTOR"/> <bbox w="160.0" h="62.0" x="4597.022" y="1317.4706"/> <glyph class="state variable" id="_21758864-0c65-46db-af77-bdaa74422dcf"> <state value="P" variable="S1261"/> <bbox w="40.0" h="10.0" x="4584.092" y="1312.4706"/> </glyph> <glyph class="state variable" id="_25587517-5854-403b-97c5-18872c2d9070"> <state value="" variable="T2446"/> <bbox w="35.0" h="10.0" x="4732.686" y="1312.4706"/> </glyph> <glyph class="state variable" id="_44e17038-30b7-4d05-b78c-1999b1d11f23"> <state value="" variable="S2448"/> <bbox w="35.0" h="10.0" x="4738.2856" y="1374.4706"/> </glyph> <glyph class="state variable" id="_6bf68fb9-3703-48d6-98a3-db0275eda564"> <state value="P" variable="S2481"/> <bbox w="40.0" h="10.0" x="4577.022" y="1372.8408"/> </glyph> <glyph class="state variable" id="_3cc8151a-525b-47bb-bde7-d8c7fc85ece0"> <state value="" variable="Y631"/> <bbox w="30.0" h="10.0" x="4582.022" y="1343.4706"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s781_akt1_sa699"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: eukaryotic translation initiation factor 4E binding protein 1 HUGO:EIF4EBP1 HGNC:3288 ENTREZ:1978 UNIPROT:Q13541 GENECARDS:EIF4EBP1 REACTOME:84152 KEGG:1978 ATLASONC:EIF4EBP1ID40432ch8p12 WIKI:EIF4EBP1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19339977 PMID:15314020 PMID:12709531 References_end</body> </html> </notes> <label text="4E-BP*"/> <bbox w="80.0" h="40.0" x="4497.5" y="1336.0"/> <glyph class="state variable" id="_ac25ea9b-5f69-417c-a9f4-213555333478"> <state value="" variable="T37"/> <bbox w="25.0" h="10.0" x="4485.0" y="1333.4022"/> </glyph> <glyph class="state variable" id="_c81c7f92-5ab6-4fb7-98c6-c37841e5f4da"> <state value="" variable="T46"/> <bbox w="25.0" h="10.0" x="4565.0" y="1331.991"/> </glyph> <glyph class="state variable" id="_574b8d07-f634-49cb-938c-497f5d68917f"> <state value="" variable="S65"/> <bbox w="25.0" h="10.0" x="4485.0" y="1368.4851"/> </glyph> <glyph class="state variable" id="_08fa91fa-79d3-4d2c-9561-03858693d324"> <state value="" variable="T70"/> <bbox w="25.0" h="10.0" x="4564.382" y="1371.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s870_akt1_akt1_csa42" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:EIF3*:EIF4E*:M7GTP*:MLST8:MTOR:RPTOR:mRNA generic* Identifiers_end References_begin: s_akt1_re66:(MAP:survival) PMID:16286006 References_end</body> </html> </notes> <label text="(eIF3/mRNA/mTOR)"/> <bbox w="356.0" h="269.0" x="4473.625" y="1590.5"/> <glyph class="nucleic acid feature" id="akt1_akt1_s395_akt1_akt1_sa227"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end</body> </html> </notes> <label text="mRNA generic*"/> <bbox w="318.0" h="29.0" x="4502.625" y="1802.0"/> <glyph class="unit of information" id="_0f980b07-f1d0-460a-9bf4-d3046f660882"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4651.625" y="1797.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s396_akt1_akt1_sa228"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: eukaryotic translation initiation factor 4E family member 2 4EHP IF4e HUGO:EIF4E2 HGNC:3293 ENTREZ:9470 UNIPROT:O60573 GENECARDS:EIF4E2 REACTOME:92953 KEGG:9470 ATLASONC:GC_EIF4E2 WIKI:EIF4E2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17368478 References_end</body> </html> </notes> <label text="M7GTP*"/> <bbox w="49.0" h="45.0" x="4476.625" y="1799.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s397_akt1_akt1_sa229"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: eukaryotic translation initiation factor 4E HUGO:EIF4E HGNC:3287 ENTREZ:1977 UNIPROT:P06730 GENECARDS:EIF4E REACTOME:72577 KEGG:1977 ATLASONC:EIF4EID40431ch4q23 WIKI:EIF4E eukaryotic translation initiation factor 4E family member 1B HUGO:EIF4E1B HGNC:33179 ENTREZ:253314 UNIPROT:A6NMX2 GENECARDS:EIF4E1B WIKI:EIF4E1B eukaryotic translation initiation factor 4E family member 2 HUGO:EIF4E2 HGNC:3293 ENTREZ:9470 UNIPROT:O60573 GENECARDS:EIF4E2 REACTOME:92953 KEGG:9470 ATLASONC:GC_EIF4E2 WIKI:EIF4E2 eukaryotic translation initiation factor 4E family member 3 HUGO:EIF4E3 HGNC:31837 ENTREZ:317649 UNIPROT:Q8N5X7 GENECARDS:EIF4E3 REACTOME:232515 WIKI:EIF4E3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19597330 PMID:19339977 PMID:18391071 References_end</body> </html> </notes> <label text="EIF4E*"/> <bbox w="113.0" h="38.0" x="4476.625" y="1761.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s398_akt1_akt1_sa230"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: eukaryotic translation initiation factor 3 subunit A HUGO:EIF3A HGNC:3271 ENTREZ:8661 UNIPROT:Q14152 GENECARDS:EIF3A REACTOME:72545 KEGG:3692 ATLASONC:EIF3AID40425ch10q26 WIKI:EIF3A eukaryotic translation initiation factor 3 subunit B HUGO:EIF3B HGNC:3280 ENTREZ:8662 UNIPROT:P55884 GENECARDS:EIF3B REACTOME:72541 KEGG:8662 ATLASONC:GC_EIF3B WIKI:EIF3B eukaryotic translation initiation factor 3 subunit C HUGO:EIF3C HGNC:3279 ENTREZ:8663 UNIPROT:Q99613 GENECARDS:EIF3C REACTOME:72549 KEGG:8663 ATLASONC:EIF3CID44187ch16p11 WIKI:EIF3C eukaryotic translation initiation factor 3 subunit D HUGO:EIF3D HGNC:3278 ENTREZ:8664 UNIPROT:O15371 GENECARDS:EIF3D REACTOME:72547 KEGG:8664 WIKI:EIF3D eukaryotic translation initiation factor 3 subunit E HUGO:EIF3E HGNC:3277 ENTREZ:3646 UNIPROT:P60228 GENECARDS:EIF3E REACTOME:72551 KEGG:3646 ATLASONC:GC_EIF3E WIKI:EIF3E eukaryotic translation initiation factor 3 subunit F HUGO:EIF3F HGNC:3275 ENTREZ:8665 UNIPROT:O00303 GENECARDS:EIF3F REACTOME:72539 KEGG:8665 ATLASONC:EIF3FID44407ch11p15 WIKI:EIF3F eukaryotic translation initiation factor 3 subunit G HUGO:EIF3G HGNC:3274 ENTREZ:8666 UNIPROT:O75821 GENECARDS:EIF3G REACTOME:72537 KEGG:8666 WIKI:EIF3G eukaryotic translation initiation factor 3 subunit H HUGO:EIF3H HGNC:3273 ENTREZ:8667 UNIPROT:O15372 GENECARDS:EIF3H REACTOME:72543 KEGG:8667 ATLASONC:GC_EIF3H WIKI:EIF3H eukaryotic translation initiation factor 3 subunit I HUGO:EIF3I HGNC:3272 ENTREZ:8668 UNIPROT:Q13347 GENECARDS:EIF3I REACTOME:72535 KEGG:8668 ATLASONC:GC_EIF3I WIKI:EIF3I eukaryotic translation initiation factor 3 subunit J HUGO:EIF3J HGNC:3270 ENTREZ:8669 UNIPROT:O75822 GENECARDS:EIF3J REACTOME:72533 KEGG:8669 WIKI:EIF3J eukaryotic translation initiation factor 3 subunit K HUGO:EIF3K HGNC:24656 ENTREZ:27335 UNIPROT:Q9UBQ5 GENECARDS:EIF3K REACTOME:72553 KEGG:27335 ATLASONC:GC_EIF3K WIKI:EIF3K eukaryotic translation initiation factor 3 subunit L HUGO:EIF3L HGNC:18138 ENTREZ:51386 UNIPROT:Q9Y262 GENECARDS:EIF3L KEGG:51386 WIKI:EIF3L eukaryotic translation initiation factor 3 subunit M HUGO:EIF3M HGNC:24460 ENTREZ:10480 UNIPROT:Q7L2H7 GENECARDS:EIF3M KEGG:10480 ATLASONC:GC_EIF3M WIKI:EIF3M Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16286006 PMID:20647036 References_end</body> </html> </notes> <label text="EIF3*"/> <bbox w="80.0" h="40.0" x="4591.625" y="1759.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s701_akt1_akt1_sa459"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 GENECARDS:MTOR REACTOME:54978 KEGG:2475 ATLASONC:FRAP1ID40639ch1p36 WIKI:MTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19568798 PMID:17680028 PMID:21157483 References_end</body> </html> </notes> <label text="MTOR"/> <bbox w="160.0" h="62.0" x="4591.022" y="1693.7646"/> <glyph class="state variable" id="_7737c4c5-e3d9-417d-9548-8f31cd256043"> <state value="P" variable="S1261"/> <bbox w="40.0" h="10.0" x="4578.092" y="1688.7646"/> </glyph> <glyph class="state variable" id="_30ad23f7-6402-4fcb-b3b4-541d006a77b5"> <state value="" variable="T2446"/> <bbox w="35.0" h="10.0" x="4726.686" y="1688.7646"/> </glyph> <glyph class="state variable" id="_e9f6597d-0c38-41d1-807f-0b7b646bb529"> <state value="" variable="S2448"/> <bbox w="35.0" h="10.0" x="4732.2856" y="1750.7646"/> </glyph> <glyph class="state variable" id="_80335bc3-2143-4573-841a-040ec9a0131a"> <state value="P" variable="S2481"/> <bbox w="40.0" h="10.0" x="4571.022" y="1749.1348"/> </glyph> <glyph class="state variable" id="_24d4de00-4e31-4de2-a8e2-445c28aa612e"> <state value="" variable="Y631"/> <bbox w="30.0" h="10.0" x="4576.022" y="1719.7646"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s702_akt1_akt1_sa460"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: regulatory associated protein of MTOR complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 GENECARDS:RPTOR REACTOME:153287 KEGG:57521 ATLASONC:GC_RPTOR WIKI:RPTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19864431 PMID:12150925 PMID:15755954 References_end</body> </html> </notes> <label text="RPTOR"/> <bbox w="140.0" h="46.0" x="4601.522" y="1643.7646"/> <glyph class="state variable" id="_e1ccf75c-4366-4d25-8af0-5bb0d852474e"> <state value="P" variable="S696"/> <bbox w="35.0" h="10.0" x="4584.022" y="1661.728"/> </glyph> <glyph class="state variable" id="_eb0c230d-ed40-4ff1-9c30-6324af307f1e"> <state value="P" variable="T706"/> <bbox w="35.0" h="10.0" x="4618.5347" y="1638.7646"/> </glyph> <glyph class="state variable" id="_666d3b56-7456-4ae9-b2f2-6611ccadc9bc"> <state value="P" variable="S855"/> <bbox w="35.0" h="10.0" x="4683.683" y="1638.7646"/> </glyph> <glyph class="state variable" id="_aeabf705-1eef-4466-b112-21d5ea8c902d"> <state value="P" variable="S863"/> <bbox w="35.0" h="10.0" x="4683.4204" y="1684.7646"/> </glyph> <glyph class="state variable" id="_82dedb90-8b56-4b8e-bf0e-9e0781a8a9cf"> <state value="P" variable="S877"/> <bbox w="35.0" h="10.0" x="4620.863" y="1684.7646"/> </glyph> <glyph class="state variable" id="_56dcce18-9c05-42b7-b830-d8c68f084601"> <state value="P" variable="S859"/> <bbox w="35.0" h="10.0" x="4724.022" y="1659.2244"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s703_akt1_akt1_sa461"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MTOR associated protein LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 GENECARDS:MLST8 REACTOME:355793 KEGG:64223 WIKI:MLST8 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:12408816 References_end</body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="4620.772" y="1600.7646"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s871_akt1_akt1_csa46" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:EIF3*:EIF4A*:EIF4B:EIF4E*:EIF4G*:M7GTP*:MLST8:MTOR:PABP1*:RPS6:RPTOR:mRNA generic* Identifiers_end References_begin: s_akt1_re77:(MAP:survival) PMID:16286006 s_akt1_re163:(MAP:survival) PMID:21177869 References_end</body> </html> </notes> <label text="(eIF3/mRNA/mTOR)"/> <bbox w="366.0" h="322.0" x="4460.5" y="1938.5"/> <glyph class="nucleic acid feature" id="akt1_akt1_s401_akt1_akt1_sa255"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end</body> </html> </notes> <label text="mRNA generic*"/> <bbox w="318.0" h="29.0" x="4495.5" y="2149.0"/> <glyph class="unit of information" id="_d4463b4c-6702-4738-9eab-4c796f2de239"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4644.5" y="2144.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s402_akt1_akt1_sa256"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: eukaryotic translation initiation factor 4E family member 2 4EHP IF4e HUGO:EIF4E2 HGNC:3293 ENTREZ:9470 UNIPROT:O60573 GENECARDS:EIF4E2 REACTOME:92953 KEGG:9470 ATLASONC:GC_EIF4E2 WIKI:EIF4E2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17368478 References_end</body> </html> </notes> <label text="M7GTP*"/> <bbox w="49.0" h="45.0" x="4469.5" y="2146.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s403_akt1_akt1_sa257"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: eukaryotic translation initiation factor 4E HUGO:EIF4E HGNC:3287 ENTREZ:1977 UNIPROT:P06730 GENECARDS:EIF4E REACTOME:72577 KEGG:1977 ATLASONC:EIF4EID40431ch4q23 WIKI:EIF4E eukaryotic translation initiation factor 4E family member 1B HUGO:EIF4E1B HGNC:33179 ENTREZ:253314 UNIPROT:A6NMX2 GENECARDS:EIF4E1B WIKI:EIF4E1B eukaryotic translation initiation factor 4E family member 2 HUGO:EIF4E2 HGNC:3293 ENTREZ:9470 UNIPROT:O60573 GENECARDS:EIF4E2 REACTOME:92953 KEGG:9470 ATLASONC:GC_EIF4E2 WIKI:EIF4E2 eukaryotic translation initiation factor 4E family member 3 HUGO:EIF4E3 HGNC:31837 ENTREZ:317649 UNIPROT:Q8N5X7 GENECARDS:EIF4E3 REACTOME:232515 WIKI:EIF4E3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19597330 PMID:19339977 PMID:18391071 References_end</body> </html> </notes> <label text="EIF4E*"/> <bbox w="113.0" h="38.0" x="4469.5" y="2108.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s404_akt1_akt1_sa258"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: eukaryotic translation initiation factor 3 subunit A HUGO:EIF3A HGNC:3271 ENTREZ:8661 UNIPROT:Q14152 GENECARDS:EIF3A REACTOME:72545 KEGG:3692 ATLASONC:EIF3AID40425ch10q26 WIKI:EIF3A eukaryotic translation initiation factor 3 subunit B HUGO:EIF3B HGNC:3280 ENTREZ:8662 UNIPROT:P55884 GENECARDS:EIF3B REACTOME:72541 KEGG:8662 ATLASONC:GC_EIF3B WIKI:EIF3B eukaryotic translation initiation factor 3 subunit C HUGO:EIF3C HGNC:3279 ENTREZ:8663 UNIPROT:Q99613 GENECARDS:EIF3C REACTOME:72549 KEGG:8663 ATLASONC:EIF3CID44187ch16p11 WIKI:EIF3C eukaryotic translation initiation factor 3 subunit D HUGO:EIF3D HGNC:3278 ENTREZ:8664 UNIPROT:O15371 GENECARDS:EIF3D REACTOME:72547 KEGG:8664 WIKI:EIF3D eukaryotic translation initiation factor 3 subunit E HUGO:EIF3E HGNC:3277 ENTREZ:3646 UNIPROT:P60228 GENECARDS:EIF3E REACTOME:72551 KEGG:3646 ATLASONC:GC_EIF3E WIKI:EIF3E eukaryotic translation initiation factor 3 subunit F HUGO:EIF3F HGNC:3275 ENTREZ:8665 UNIPROT:O00303 GENECARDS:EIF3F REACTOME:72539 KEGG:8665 ATLASONC:EIF3FID44407ch11p15 WIKI:EIF3F eukaryotic translation initiation factor 3 subunit G HUGO:EIF3G HGNC:3274 ENTREZ:8666 UNIPROT:O75821 GENECARDS:EIF3G REACTOME:72537 KEGG:8666 WIKI:EIF3G eukaryotic translation initiation factor 3 subunit H HUGO:EIF3H HGNC:3273 ENTREZ:8667 UNIPROT:O15372 GENECARDS:EIF3H REACTOME:72543 KEGG:8667 ATLASONC:GC_EIF3H WIKI:EIF3H eukaryotic translation initiation factor 3 subunit I HUGO:EIF3I HGNC:3272 ENTREZ:8668 UNIPROT:Q13347 GENECARDS:EIF3I REACTOME:72535 KEGG:8668 ATLASONC:GC_EIF3I WIKI:EIF3I eukaryotic translation initiation factor 3 subunit J HUGO:EIF3J HGNC:3270 ENTREZ:8669 UNIPROT:O75822 GENECARDS:EIF3J REACTOME:72533 KEGG:8669 WIKI:EIF3J eukaryotic translation initiation factor 3 subunit K HUGO:EIF3K HGNC:24656 ENTREZ:27335 UNIPROT:Q9UBQ5 GENECARDS:EIF3K REACTOME:72553 KEGG:27335 ATLASONC:GC_EIF3K WIKI:EIF3K eukaryotic translation initiation factor 3 subunit L HUGO:EIF3L HGNC:18138 ENTREZ:51386 UNIPROT:Q9Y262 GENECARDS:EIF3L KEGG:51386 WIKI:EIF3L eukaryotic translation initiation factor 3 subunit M HUGO:EIF3M HGNC:24460 ENTREZ:10480 UNIPROT:Q7L2H7 GENECARDS:EIF3M KEGG:10480 ATLASONC:GC_EIF3M WIKI:EIF3M Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16286006 PMID:20647036 References_end</body> </html> </notes> <label text="EIF3*"/> <bbox w="80.0" h="40.0" x="4584.5" y="2106.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s399_akt1_akt1_sa262"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: eukaryotic translation initiation factor 4A1 HUGO:EIF4A1 HGNC:3282 ENTREZ:1973 UNIPROT:P60842 GENECARDS:EIF4A1 REACTOME:72572 KEGG:1973 ATLASONC:GC_EIF4A1 WIKI:EIF4A1 eukaryotic translation initiation factor 4A2 HUGO:EIF4A2 HGNC:3284 ENTREZ:1974 UNIPROT:Q14240 GENECARDS:EIF4A2 REACTOME:72574 KEGG:1974 ATLASONC:EIF4A2ID262 WIKI:EIF4A2 eukaryotic translation initiation factor 4A3 HUGO:EIF4A3 HGNC:18683 ENTREZ:9775 UNIPROT:P38919 GENECARDS:EIF4A3 REACTOME:57148 KEGG:9775 ATLASONC:GC_EIF4A3 WIKI:EIF4A3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12867079 PMID:19339977 References_end</body> </html> </notes> <label text="EIF4A*"/> <bbox w="80.0" h="40.0" x="4739.5" y="2108.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s409_akt1_akt1_sa263"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: eukaryotic translation initiation factor 4B HUGO:EIF4B HGNC:3285 ENTREZ:1975 UNIPROT:P23588 GENECARDS:EIF4B REACTOME:72588 KEGG:1975 WIKI:EIF4B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12867079 PMID:19339977 References_end</body> </html> </notes> <label text="EIF4B"/> <bbox w="80.0" h="40.0" x="4664.5" y="2107.0"/> <glyph class="state variable" id="_16ba546e-c7ff-41e0-be85-0defbc254800"> <state value="P" variable="S422"/> <bbox w="35.0" h="10.0" x="4647.4927" y="2102.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s410_akt1_akt1_sa264"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ribosomal protein S6 HUGO:RPS6 HGNC:10429 ENTREZ:6194 UNIPROT:P62753 GENECARDS:RPS6 REACTOME:72380 KEGG:6194 ATLASONC:GC_RPS6 WIKI:RPS6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16679021 PMID:21233202 References_end</body> </html> </notes> <label text="RPS6"/> <bbox w="114.0" h="53.0" x="4581.5" y="2183.0"/> <glyph class="state variable" id="_4e51712c-18e7-4196-816d-d07e54a6b097"> <state value="P" variable="S235"/> <bbox w="35.0" h="10.0" x="4564.0" y="2229.6067"/> </glyph> <glyph class="state variable" id="_847ff9c3-94c4-4cdc-b142-b549d42190d8"> <state value="P" variable="S236"/> <bbox w="35.0" h="10.0" x="4564.0" y="2179.2327"/> </glyph> <glyph class="state variable" id="_de560c4f-29a7-42b8-bcb9-9ab8b4758cb1"> <state value="P" variable="S240"/> <bbox w="35.0" h="10.0" x="4678.0" y="2179.313"/> </glyph> <glyph class="state variable" id="_2e94dd76-0d3c-4ea6-a750-4ede616c0ea9"> <state value="P" variable="S244"/> <bbox w="35.0" h="10.0" x="4672.797" y="2231.0"/> </glyph> <glyph class="state variable" id="_3ea27e77-d6ac-42dd-b0fe-aad2d0d3cbbc"> <state value="P" variable="S247"/> <bbox w="35.0" h="10.0" x="4619.7236" y="2231.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s412_akt1_akt1_sa266"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: eukaryotic translation initiation factor 4 gamma 1 HUGO:EIF4G1 HGNC:3296 ENTREZ:1981 UNIPROT:Q04637 GENECARDS:EIF4G1 REACTOME:72583 KEGG:1981 ATLASONC:GC_EIF4G1 WIKI:EIF4G1 eukaryotic translation initiation factor 4 gamma 2 HUGO:EIF4G2 HGNC:3297 ENTREZ:1982 UNIPROT:P78344 GENECARDS:EIF4G2 REACTOME:92738 KEGG:1982 ATLASONC:GC_EIF4G2 WIKI:EIF4G2 eukaryotic translation initiation factor 4 gamma 3 HUGO:EIF4G3 HGNC:3298 ENTREZ:8672 UNIPROT:O43432 GENECARDS:EIF4G3 REACTOME:148636 KEGG:8672 ATLASONC:GC_EIF4G3 WIKI:EIF4G3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12867079 PMID:19339977 References_end</body> </html> </notes> <label text="EIF4G*"/> <bbox w="80.0" h="40.0" x="4497.5" y="2066.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s414_akt1_akt1_sa268"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: poly(A) binding protein cytoplasmic 1 HUGO:PABPC1 HGNC:8554 ENTREZ:26986 UNIPROT:P11940 GENECARDS:PABPC1 REACTOME:72228 KEGG:26986 ATLASONC:GC_PABPC1 WIKI:PABPC1 poly(A) binding protein cytoplasmic 3 HUGO:PABPC3 HGNC:8556 ENTREZ:5042 UNIPROT:Q9H361 GENECARDS:PABPC3 KEGG:5042 WIKI:PABPC3 poly(A) binding protein cytoplasmic 5 HUGO:PABP5 GENECARDS:PABP5 WIKI:PABP5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12844354 PMID:15905173 References_end</body> </html> </notes> <label text="PABP1*"/> <bbox w="80.0" h="40.0" x="4498.5" y="2025.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s704_akt1_akt1_sa462"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 GENECARDS:MTOR REACTOME:54978 KEGG:2475 ATLASONC:FRAP1ID40639ch1p36 WIKI:MTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19568798 PMID:17680028 PMID:21157483 References_end</body> </html> </notes> <label text="MTOR"/> <bbox w="160.0" h="62.0" x="4587.897" y="2038.5294"/> <glyph class="state variable" id="_03e76852-e9e4-4b16-9c98-ab01ef4d1035"> <state value="P" variable="S1261"/> <bbox w="40.0" h="10.0" x="4574.967" y="2033.5294"/> </glyph> <glyph class="state variable" id="_4f5e9c81-cf9d-4db9-aa7e-b50889883b1f"> <state value="" variable="T2446"/> <bbox w="35.0" h="10.0" x="4723.561" y="2033.5294"/> </glyph> <glyph class="state variable" id="_3cc7624b-2305-49f9-8d7b-526917b8aa03"> <state value="" variable="S2448"/> <bbox w="35.0" h="10.0" x="4729.1606" y="2095.5293"/> </glyph> <glyph class="state variable" id="_ef24ef11-1784-4356-a34f-bf7972252e51"> <state value="P" variable="S2481"/> <bbox w="40.0" h="10.0" x="4567.897" y="2093.8997"/> </glyph> <glyph class="state variable" id="_df078507-ff33-461c-a7fa-f7c5a031bf4b"> <state value="" variable="Y631"/> <bbox w="30.0" h="10.0" x="4572.897" y="2064.5293"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s705_akt1_akt1_sa463"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: regulatory associated protein of MTOR complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 GENECARDS:RPTOR REACTOME:153287 KEGG:57521 ATLASONC:GC_RPTOR WIKI:RPTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19864431 PMID:12150925 PMID:15755954 References_end</body> </html> </notes> <label text="RPTOR"/> <bbox w="140.0" h="46.0" x="4597.397" y="1987.5294"/> <glyph class="state variable" id="_244d5b8c-2cf5-4889-b73c-d5018689e86e"> <state value="P" variable="S696"/> <bbox w="35.0" h="10.0" x="4579.897" y="2005.4928"/> </glyph> <glyph class="state variable" id="_4546c706-3612-4d7a-ad7b-29c5c1a2b09f"> <state value="P" variable="T706"/> <bbox w="35.0" h="10.0" x="4614.4097" y="1982.5294"/> </glyph> <glyph class="state variable" id="_6bca96d0-1a3a-4c14-b523-4b894b83310b"> <state value="P" variable="S855"/> <bbox w="35.0" h="10.0" x="4679.558" y="1982.5294"/> </glyph> <glyph class="state variable" id="_ce6fc2ca-c862-4e68-be3e-414de79842f9"> <state value="P" variable="S863"/> <bbox w="35.0" h="10.0" x="4679.2954" y="2028.5294"/> </glyph> <glyph class="state variable" id="_059b9e75-53f4-422e-a29d-ef43d2ba8903"> <state value="P" variable="S877"/> <bbox w="35.0" h="10.0" x="4616.738" y="2028.5294"/> </glyph> <glyph class="state variable" id="_19eda9bc-5b04-4451-9f64-96ba9b798721"> <state value="P" variable="S859"/> <bbox w="35.0" h="10.0" x="4719.897" y="2002.9891"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s706_akt1_akt1_sa464"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MTOR associated protein LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 GENECARDS:MLST8 REACTOME:355793 KEGG:64223 WIKI:MLST8 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:12408816 References_end</body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="4620.647" y="1945.5294"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s872_akt1_akt1_csa48" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DEK:REF*:RNPS1:SRM160*:Y14* Identifiers_end References_begin: s_akt1_re79(MAP:survival): PMID:18423201 PMID:19339977 References_end</body> </html> </notes> <label text="(EJC)"/> <bbox w="180.0" h="160.0" x="5118.0" y="2220.0"/> <glyph class="macromolecule" id="akt1_akt1_s417_akt1_akt1_sa270"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: serine/arginine repetitive matrix 1 HUGO:SRRM1 HGNC:16638 ENTREZ:10250 UNIPROT:Q8IYB3 GENECARDS:SRRM1 REACTOME:249492 KEGG:10250 WIKI:SRRM1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11532962 PMID:18423201 References_end</body> </html> </notes> <label text="SRM160*"/> <bbox w="80.0" h="40.0" x="5123.0" y="2228.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s418_akt1_akt1_sa271"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DEK oncogene HUGO:DEK HGNC:2768 ENTREZ:7913 UNIPROT:P35659 GENECARDS:DEK KEGG:7913 ATLASONC:DEK_23 WIKI:DEK Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11532962 References_end</body> </html> </notes> <label text="DEK"/> <bbox w="80.0" h="40.0" x="5123.0" y="2271.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s707_akt1_akt1_sa465"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RNA binding protein S1 serine-rich domain HUGO:RNPS1 HGNC:10080 ENTREZ:10921 UNIPROT:Q15287 GENECARDS:RNPS1 REACTOME:156734 KEGG:10921 WIKI:RNPS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11532962 References_end</body> </html> </notes> <label text="RNPS1"/> <bbox w="80.0" h="40.0" x="5123.0" y="2312.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s708_akt1_akt1_sa466"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Aly/REF export factor HUGO:ALYREF HGNC:19071 ENTREZ:10189 UNIPROT:Q86V81 GENECARDS:ALYREF REACTOME:103403 KEGG:10189 ATLASONC:GC_ALYREF WIKI:ALYREF Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:10786854 References_end</body> </html> </notes> <label text="REF*"/> <bbox w="80.0" h="40.0" x="5205.0" y="2228.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s709_akt1_akt1_sa467"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RNA binding motif protein 8A HUGO:RBM8A HGNC:9905 ENTREZ:9939 UNIPROT:Q9Y5S9 GENECARDS:RBM8A REACTOME:72303 KEGG:9939 ATLASONC:GC_RBM8A WIKI:RBM8A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11532962 References_end</body> </html> </notes> <label text="Y14*"/> <bbox w="80.0" h="40.0" x="5205.0" y="2270.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s873_akt1_akt1_csa84" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MLST8:MTOR:PRAS40*:RAC1:RPTOR Identifiers_end References_begin: s_akt1_re113:(MAP:survival) PMID:21474067 References_end</body> </html> </notes> <label text="(mTORC1)"/> <bbox w="194.0" h="256.0" x="5348.5" y="1733.0"/> <glyph class="macromolecule" id="akt1_akt1_s781_akt1_akt1_sa513"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: AKT1 substrate 1 (proline-rich) HUGO:AKT1S1 HGNC:28426 ENTREZ:84335 UNIPROT:Q96B36 GENECARDS:AKT1S1 REACTOME:200146 KEGG:84335 ATLASONC:GC_AKT1S1 WIKI:AKT1S1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18372248 PMID:17604271 References_end</body> </html> </notes> <label text="PRAS40*"/> <bbox w="160.0" h="57.0" x="5360.5" y="1744.0"/> <glyph class="state variable" id="_5bedebe9-68c7-49b4-aaa7-f1234e0f1c62"> <state value="" variable="S183"/> <bbox w="30.0" h="10.0" x="5346.485" y="1739.0"/> </glyph> <glyph class="state variable" id="_790d5d93-0bbe-4fcb-b578-ab5599515444"> <state value="" variable="T246"/> <bbox w="30.0" h="10.0" x="5345.5" y="1790.4719"/> </glyph> <glyph class="state variable" id="_98136b5e-0570-4427-8d9b-85f4d57fee4e"> <state value="" variable="S212"/> <bbox w="30.0" h="10.0" x="5505.5" y="1740.4121"/> </glyph> <glyph class="state variable" id="_4a04c9b2-4c07-4228-9c89-25e20ebac18d"> <state value="" variable="S221"/> <bbox w="30.0" h="10.0" x="5505.5" y="1794.7612"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s782_akt1_akt1_sa514"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MTOR associated protein LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 GENECARDS:MLST8 REACTOME:355793 KEGG:64223 WIKI:MLST8 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:12408816 References_end</body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="5361.0" y="1804.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s783_akt1_akt1_sa515"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: regulatory associated protein of MTOR complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 GENECARDS:RPTOR REACTOME:153287 KEGG:57521 ATLASONC:GC_RPTOR WIKI:RPTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19864431 PMID:12150925 PMID:15755954 References_end</body> </html> </notes> <label text="RPTOR"/> <bbox w="169.0" h="51.0" x="5358.0" y="1847.5"/> <glyph class="state variable" id="_a7759b1a-7b9d-47b7-939c-86db97cf93c4"> <state value="" variable="S696"/> <bbox w="30.0" h="10.0" x="5343.0" y="1867.9594"/> </glyph> <glyph class="state variable" id="_413acb91-9282-4720-96f4-e50bca6ea279"> <state value="" variable="T706"/> <bbox w="30.0" h="10.0" x="5384.6616" y="1842.5"/> </glyph> <glyph class="state variable" id="_45dd1f81-eb8d-44e6-b6cc-cca22435e093"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="5463.305" y="1842.5"/> </glyph> <glyph class="state variable" id="_c57157f2-3e30-4476-bed7-2b4716fb7e5b"> <state value="" variable="S863"/> <bbox w="30.0" h="10.0" x="5462.9883" y="1893.5"/> </glyph> <glyph class="state variable" id="_7224f1e7-67ef-4dcc-824f-acb33870a1e9"> <state value="" variable="S877"/> <bbox w="30.0" h="10.0" x="5387.472" y="1893.5"/> </glyph> <glyph class="state variable" id="_c7d175cf-2432-446d-8436-6fd6c02197ab"> <state value="" variable="S859"/> <bbox w="30.0" h="10.0" x="5512.0" y="1865.1836"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s784_akt1_akt1_sa516"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 GENECARDS:MTOR REACTOME:54978 KEGG:2475 ATLASONC:FRAP1ID40639ch1p36 WIKI:MTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19568798 PMID:17680028 PMID:21157483 References_end</body> </html> </notes> <label text="MTOR"/> <bbox w="171.0" h="59.0" x="5357.0" y="1909.0"/> <glyph class="state variable" id="_a27b6cc5-bb7a-4fb7-bbcb-c39cfa98b4f1"> <state value="" variable="S1261"/> <bbox w="35.0" h="10.0" x="5347.0557" y="1904.0"/> </glyph> <glyph class="state variable" id="_398d32b1-1a9a-4041-807c-d3058a4c477e"> <state value="" variable="T2446"/> <bbox w="35.0" h="10.0" x="5503.1943" y="1904.0"/> </glyph> <glyph class="state variable" id="_948eb6a2-f086-4968-aaaa-f950d25c64fa"> <state value="P" variable="S2448"/> <bbox w="40.0" h="10.0" x="5506.6787" y="1963.0"/> </glyph> <glyph class="state variable" id="_e5a03c2e-eb21-4c0d-b5fa-516234e2ba9c"> <state value="" variable="S2481"/> <bbox w="35.0" h="10.0" x="5339.5" y="1961.4491"/> </glyph> <glyph class="state variable" id="_9165ccb3-0c36-4eeb-8034-5b42cb48103c"> <state value="" variable="Y631"/> <bbox w="30.0" h="10.0" x="5342.0" y="1933.5"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s786_akt1_akt1_sa518"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <bbox w="80.0" h="40.0" x="5444.5" y="1806.0"/> <glyph class="state variable" id="_ecf7320c-6b5f-4f0b-9a4a-5c573ceabe36"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5439.5" y="1821.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s874_akt1_akt1_csa70" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CUL1:RBX1:SKP1:_beta_TRCP* Identifiers_end</body> </html> </notes> <label text="(SCF)"/> <bbox w="173.0" h="122.0" x="5690.5" y="835.0"/> <glyph class="macromolecule" id="akt1_akt1_s619_akt1_akt1_sa420"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Beta-transducin repeat domain HUGO:BTRC HGNC:1144 ENTREZ:8945 UNIPROT:Q9Y297 GENECARDS:BTRC REACTOME:55056 KEGG:8945 ATLASONC:BTRCID451ch10q24 WIKI:BTRC F-box and WD repeat domain containing 11 BTRC2, BTRCP2, Fbw1b, Fbw11, Hos, KIAA0696 HUGO:FBXW11 HGNC:13607 ENTREZ:23291 UNIPROT:Q9UKB1 GENECARDS:FBXW11 REACTOME:55058 KEGG:23291 WIKI:FBXW11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 E3 Ligase subunit References_end Identifiers_begin: Beta-transducin repeat domain HUGO:BTRC HGNC:1144 ENTREZ:8945 UNIPROT:Q9Y297 GENECARDS:BTRC REACTOME:55056 KEGG:8945 ATLASONC:BTRCID451ch10q24 WIKI:BTRC F-box and WD repeat domain containing 11 BTRC2, BTRCP2, Fbw1b, Fbw11, Hos, KIAA0696 HUGO:FBXW11 HGNC:13607 ENTREZ:23291 UNIPROT:Q9UKB1 GENECARDS:FBXW11 REACTOME:55058 KEGG:23291 WIKI:FBXW11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 E3 Ligase subunit References_end</body> </html> Identifiers_begin: Beta-transducin repeat domain HUGO:BTRC HGNC:1144 ENTREZ:8945 UNIPROT:Q9Y297 GENECARDS:BTRC REACTOME:55056 KEGG:8945 ATLASONC:BTRCID451ch10q24 WIKI:BTRC F-box and WD repeat domain containing 11 BTRC2, BTRCP2, Fbw1b, Fbw11, Hos, KIAA0696 HUGO:FBXW11 HGNC:13607 ENTREZ:23291 UNIPROT:Q9UKB1 GENECARDS:FBXW11 REACTOME:55058 KEGG:23291 WIKI:FBXW11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 E3 Ligase subunit References_end</body> </html> </notes> <label text="βTRCP*"/> <bbox w="80.0" h="40.0" x="5697.5" y="850.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s620_akt1_akt1_sa421"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 "S-phase kinase-associated protein 1A (p19A)", SKP1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 "S-phase kinase-associated protein 1A (p19A)", SKP1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 "S-phase kinase-associated protein 1A (p19A)", SKP1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> </notes> <label text="SKP1"/> <bbox w="80.0" h="40.0" x="5778.5" y="850.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s621_akt1_akt1_sa422"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> </notes> <label text="CUL1"/> <bbox w="80.0" h="40.0" x="5698.5" y="893.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s622_akt1_akt1_sa423"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> </notes> <label text="RBX1"/> <bbox w="80.0" h="40.0" x="5778.5" y="893.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s875_akt1_akt1_csa65" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APAF1:Caspase9*:Cytochrome_C*:dATP/ATP Identifiers_end References_begin: s_akt1_re178(MAP:survival): PMID:19788417 PMID:16977332 References_end</body> </html> </notes> <label text="(Apoptosome)"/> <bbox w="186.0" h="113.0" x="6084.0" y="908.0"/> <glyph class="macromolecule" id="akt1_akt1_s572_akt1_akt1_sa377"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cytochrome c somatic HUGO:CYCS HGNC:19986 ENTREZ:54205 UNIPROT:P99999 GENECARDS:CYCS REACTOME:53260 KEGG:54205 ATLASONC:GC_CYCS WIKI:CYCS Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19788417 PMID:16977332 References_end</body> </html> </notes> <label text="Cytochrome_C*"/> <bbox w="80.0" h="40.0" x="6179.0" y="912.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s573_akt1_akt1_sa378"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: apoptotic peptidase activating factor 1 HUGO:APAF1 HGNC:576 ENTREZ:317 UNIPROT:O14727 GENECARDS:APAF1 REACTOME:50100 KEGG:317 ATLASONC:APAF1ID422 WIKI:APAF1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19788417 PMID:16977332 References_end</body> </html> </notes> <label text="APAF1"/> <bbox w="80.0" h="40.0" x="6097.0" y="913.0"/> </glyph> <glyph class="simple chemical" id="akt1_akt1_s574_akt1_akt1_sa379"> <label text="dATP/ATP"/> <bbox w="70.0" h="25.0" x="6179.0" y="951.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s717_akt1_akt1_sa474"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: caspase 9 apoptosis-related cysteine peptidase "caspase 9 apoptosis-related cysteine protease" HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Caspase9 is phosphorylated on Thr125 in a MEK1/2-dependent manner in vivo. Furthermore caspase9 is efficiently phosphorylated on Thr125 by ERK in vitro suggesting that it is targeted directly by ERK in vivo. This is one of the ways ERK plays its anti-apoptotic role. PMID:12792650 References_end Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 GENECARDS:CASP9 REACTOME:57034 KEGG:842 ATLASONC:CASP9ID423ch1p36 WIKI:CASP9 "caspase 9 apoptosis-related cysteine protease" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19788417 PMID:16977332 Caspase9 is phosphorylated on Thr125 in a MEK1/2-dependent manner in vivo. Furthermore caspase9 is efficiently phosphorylated on Thr125 by ERK in vitro suggesting that it is targeted directly by ERK in vivo. This is one of the ways ERK plays its anti-apoptotic role. PMID:12792650 References_end</body> </html> Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 GENECARDS:CASP9 REACTOME:57034 KEGG:842 ATLASONC:CASP9ID423ch1p36 WIKI:CASP9 "caspase 9 apoptosis-related cysteine protease" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19788417 PMID:16977332 Caspase9 is phosphorylated on Thr125 in a MEK1/2-dependent manner in vivo. Furthermore caspase9 is efficiently phosphorylated on Thr125 by ERK in vitro suggesting that it is targeted directly by ERK in vivo. This is one of the ways ERK plays its anti-apoptotic role. PMID:12792650 References_end</body> </html> </notes> <label text="Caspase9*"/> <bbox w="80.0" h="40.0" x="6097.5" y="956.0"/> <glyph class="state variable" id="_ed74b68b-0064-49a2-aab9-664bbc939097"> <state value="" variable="S196"/> <bbox w="30.0" h="10.0" x="6162.5" y="951.99097"/> </glyph> <glyph class="state variable" id="_1c5538bf-f689-4bda-aad3-009d919988ef"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6092.5" y="971.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s876_akt1_akt1_csa20" compartmentRef="akt1_akt1_c3_akt1_akt1_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TSC1:TSC2 Identifiers_end References_begin: s_akt1_re45(MAP:survival): PMID:14551205 PMID:17693255 s_akt1_re37(MAP:survival): PMID:16636147 ANNOTATION:THE PHOSPHORYLATION STATE OF TSC2 IS NOT OFF INFLUENCE ON THE GTPase ACTIVITY OF THE PROTEIN s_akt1_re61:(MAP:survival) PMID:17604271 References_end</body> </html> </notes> <label text="(TSC)"/> <bbox w="101.0" h="123.0" x="6288.222" y="1163.5354"/> <glyph class="macromolecule" id="akt1_akt1_s144_akt1_akt1_sa113"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 GENECARDS:TSC2 REACTOME:404219 KEGG:7249 ATLASONC:TSC2ID184 WIKI:TSC2 P49815 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 GENECARDS:TSC2 REACTOME:404219 KEGG:7249 ATLASONC:TSC2ID184 WIKI:TSC2 P49815 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end</body> </html> </notes> <label text="TSC2"/> <bbox w="80.0" h="40.0" x="6298.222" y="1220.5354"/> <glyph class="state variable" id="_4ce05d27-c4b5-4a20-9eb1-09fccae59d93"> <state value="" variable="S1086"/> <bbox w="35.0" h="10.0" x="6360.722" y="1237.0017"/> </glyph> <glyph class="state variable" id="_6cf4e49a-3d4b-4249-9486-9fcce1186821"> <state value="" variable="S981"/> <bbox w="30.0" h="10.0" x="6359.804" y="1215.5354"/> </glyph> <glyph class="state variable" id="_5187f4d2-1d3b-4b31-90bf-ca2bd5e43144"> <state value="" variable="S1130"/> <bbox w="35.0" h="10.0" x="6318.6245" y="1255.5354"/> </glyph> <glyph class="state variable" id="_4fe35f0d-d640-46bb-9a72-1e9903bc312b"> <state value="" variable="T1462"/> <bbox w="35.0" h="10.0" x="6281.215" y="1215.5354"/> </glyph> <glyph class="state variable" id="_30d9656c-1195-482c-bd37-bc94527c3682"> <state value="" variable="S1132"/> <bbox w="35.0" h="10.0" x="6280.722" y="1254.4839"/> </glyph> <glyph class="state variable" id="_2d462dea-c425-4bc9-9fae-842c8b74a973"> <state value="" variable="S939"/> <bbox w="30.0" h="10.0" x="6321.2524" y="1215.5354"/> </glyph> <glyph class="state variable" id="_73ea1d13-01cc-4c39-98d9-0c9f599db610"> <state value="" variable="S1088"/> <bbox w="35.0" h="10.0" x="6360.104" y="1255.5354"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s145_akt1_akt1_sa114"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: tuberous sclerosis 1 HUGO:TSC1 HGNC:12362 ENTREZ:7248 UNIPROT:Q92574 GENECARDS:TSC1 REACTOME:66499 KEGG:7248 ATLASONC:TSC1ID183 WIKI:TSC1 Q92574 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end Identifiers_begin: tuberous sclerosis 1 HUGO:TSC1 HGNC:12362 ENTREZ:7248 UNIPROT:Q92574 GENECARDS:TSC1 REACTOME:66499 KEGG:7248 ATLASONC:TSC1ID183 WIKI:TSC1 Q92574 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end</body> </html> </notes> <label text="TSC1"/> <bbox w="80.0" h="40.0" x="6299.222" y="1171.0707"/> <glyph class="state variable" id="_3bcf405f-43d7-4c68-a797-4dd383e05f70"> <state value="" variable="T417"/> <bbox w="30.0" h="10.0" x="6284.715" y="1166.0707"/> </glyph> <glyph class="state variable" id="_61fe87f2-ae3a-4cc2-9a5d-0df078b1bfbc"> <state value="" variable="S487"/> <bbox w="30.0" h="10.0" x="6364.222" y="1166.2854"/> </glyph> <glyph class="state variable" id="_fbbed7ff-9d5e-4187-bac1-cda2c2994fa0"> <state value="" variable="S584"/> <bbox w="30.0" h="10.0" x="6361.308" y="1206.0707"/> </glyph> <glyph class="state variable" id="_86c012f1-716d-45e2-a420-ef6a6484a78a"> <state value="" variable="T1047"/> <bbox w="35.0" h="10.0" x="6281.722" y="1205.793"/> </glyph> <glyph class="state variable" id="_1af636a7-a140-4583-a217-c00876cdb8e8"> <state value="" variable="S511"/> <bbox w="30.0" h="10.0" x="6364.222" y="1186.0707"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s877_akt1_akt1_csa21" compartmentRef="akt1_akt1_c3_akt1_akt1_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TSC1:TSC2 Identifiers_end</body> </html> </notes> <label text="(TSC)"/> <bbox w="100.0" h="125.0" x="6429.222" y="1162.5354"/> <glyph class="macromolecule" id="akt1_akt1_s632_akt1_akt1_sa115"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 GENECARDS:TSC2 REACTOME:404219 KEGG:7249 ATLASONC:TSC2ID184 WIKI:TSC2 P49815 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 GENECARDS:TSC2 REACTOME:404219 KEGG:7249 ATLASONC:TSC2ID184 WIKI:TSC2 P49815 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end</body> </html> </notes> <label text="TSC2"/> <bbox w="80.0" h="40.0" x="6438.222" y="1219.5354"/> <glyph class="state variable" id="_b050962d-0a2e-4eba-86d9-00cfd7c6463d"> <state value="P" variable="S1086"/> <bbox w="40.0" h="10.0" x="6498.222" y="1236.0017"/> </glyph> <glyph class="state variable" id="_a983a9f1-dc7a-45c8-a0a1-718d57cfd84f"> <state value="P" variable="S981"/> <bbox w="35.0" h="10.0" x="6497.304" y="1214.5354"/> </glyph> <glyph class="state variable" id="_40930edf-298d-481c-87c2-305254fb460d"> <state value="P" variable="S1130"/> <bbox w="40.0" h="10.0" x="6456.1245" y="1254.5354"/> </glyph> <glyph class="state variable" id="_57b09a3a-54df-4833-915f-cabd46092f91"> <state value="P" variable="T1462"/> <bbox w="40.0" h="10.0" x="6418.715" y="1214.5354"/> </glyph> <glyph class="state variable" id="_d085198a-d159-40e6-812e-23029697d5fa"> <state value="P" variable="S1132"/> <bbox w="40.0" h="10.0" x="6418.222" y="1253.4839"/> </glyph> <glyph class="state variable" id="_853edafc-4673-42ca-975c-4bf04da5d8be"> <state value="P" variable="S939"/> <bbox w="35.0" h="10.0" x="6458.7524" y="1214.5354"/> </glyph> <glyph class="state variable" id="_c15ee541-7f9f-488d-92a9-0f6334294d32"> <state value="P" variable="S1088"/> <bbox w="40.0" h="10.0" x="6497.604" y="1254.5354"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s147_akt1_akt1_sa116"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: tuberous sclerosis 1 HUGO:TSC1 HGNC:12362 ENTREZ:7248 UNIPROT:Q92574 GENECARDS:TSC1 REACTOME:66499 KEGG:7248 ATLASONC:TSC1ID183 WIKI:TSC1 Q92574 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end Identifiers_begin: tuberous sclerosis 1 HUGO:TSC1 HGNC:12362 ENTREZ:7248 UNIPROT:Q92574 GENECARDS:TSC1 REACTOME:66499 KEGG:7248 ATLASONC:TSC1ID183 WIKI:TSC1 Q92574 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end</body> </html> </notes> <label text="TSC1"/> <bbox w="80.0" h="40.0" x="6438.222" y="1168.5354"/> <glyph class="state variable" id="_9bd8fef8-e8af-45da-8191-23bc9c647f5c"> <state value="" variable="T417"/> <bbox w="30.0" h="10.0" x="6423.715" y="1163.5354"/> </glyph> <glyph class="state variable" id="_e7fd76c3-cc0e-4638-8533-0af94a27c9f1"> <state value="" variable="S487"/> <bbox w="30.0" h="10.0" x="6503.222" y="1163.7501"/> </glyph> <glyph class="state variable" id="_4d3d4fc6-a798-4195-8b1f-69f5a5f7846c"> <state value="" variable="S584"/> <bbox w="30.0" h="10.0" x="6500.308" y="1203.5354"/> </glyph> <glyph class="state variable" id="_daf7771e-b764-4d24-af12-bcbc9b2b4b88"> <state value="" variable="T1047"/> <bbox w="35.0" h="10.0" x="6420.722" y="1203.2577"/> </glyph> <glyph class="state variable" id="_f809cad1-3258-4446-9748-a2d94925bf21"> <state value="" variable="S511"/> <bbox w="30.0" h="10.0" x="6503.222" y="1183.5354"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s878_akt1_akt1_csa57" compartmentRef="akt1_akt1_c4_akt1_akt1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MLST8:MTOR:PRAS40*:RAC1:RPTOR Identifiers_end</body> </html> </notes> <label text="(mTORC1)"/> <bbox w="179.0" h="250.0" x="5843.0" y="1596.0"/> <glyph class="macromolecule" id="akt1_akt1_s789_akt1_akt1_sa332"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 GENECARDS:MTOR REACTOME:54978 KEGG:2475 ATLASONC:FRAP1ID40639ch1p36 WIKI:MTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19568798 PMID:17680028 PMID:21157483 References_end</body> </html> </notes> <label text="MTOR"/> <bbox w="156.0" h="62.0" x="5855.5" y="1764.0"/> <glyph class="state variable" id="_74961cf4-83c7-4de4-9e95-06e1fd722cab"> <state value="" variable="S1261"/> <bbox w="35.0" h="10.0" x="5844.893" y="1759.0"/> </glyph> <glyph class="state variable" id="_d04d5099-3e34-4e78-b11a-2b0f12394c2b"> <state value="" variable="T2446"/> <bbox w="35.0" h="10.0" x="5987.335" y="1759.0"/> </glyph> <glyph class="state variable" id="_01fcc745-cf51-42c7-af1e-4ffa764f803b"> <state value="P" variable="S2448"/> <bbox w="40.0" h="10.0" x="5990.2944" y="1821.0"/> </glyph> <glyph class="state variable" id="_8ebad0cb-68bc-409c-b8ce-30ef545aa5f0"> <state value="" variable="S2481"/> <bbox w="35.0" h="10.0" x="5838.0" y="1819.3701"/> </glyph> <glyph class="state variable" id="_a520014d-0fa1-40d3-93e3-3ab0a4a885cc"> <state value="" variable="Y631"/> <bbox w="30.0" h="10.0" x="5840.5" y="1790.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s790_akt1_akt1_sa333"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: regulatory associated protein of MTOR complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 GENECARDS:RPTOR REACTOME:153287 KEGG:57521 ATLASONC:GC_RPTOR WIKI:RPTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19864431 PMID:12150925 PMID:15755954 References_end</body> </html> </notes> <label text="RPTOR"/> <bbox w="170.0" h="50.0" x="5844.75" y="1709.0"/> <glyph class="state variable" id="_997abba9-2fc6-43d3-9476-0b90a85ad1ce"> <state value="" variable="S696"/> <bbox w="30.0" h="10.0" x="5829.75" y="1728.9602"/> </glyph> <glyph class="state variable" id="_b2e6ab74-999e-43df-a640-8a87307fbfb7"> <state value="" variable="T706"/> <bbox w="30.0" h="10.0" x="5871.658" y="1704.0"/> </glyph> <glyph class="state variable" id="_0cfd0de1-73e5-4158-b4f9-43899252dcec"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="5950.767" y="1704.0"/> </glyph> <glyph class="state variable" id="_bdb0dfe7-786a-48ba-bc2a-3d645411d4c3"> <state value="" variable="S863"/> <bbox w="30.0" h="10.0" x="5950.448" y="1754.0"/> </glyph> <glyph class="state variable" id="_dec653d1-fafa-4f4b-a6b2-a4f53707e36f"> <state value="" variable="S877"/> <bbox w="30.0" h="10.0" x="5874.4854" y="1754.0"/> </glyph> <glyph class="state variable" id="_c7d74690-1099-4164-a2dc-28cbaf8121f2"> <state value="" variable="S859"/> <bbox w="30.0" h="10.0" x="5999.75" y="1726.2389"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s792_akt1_akt1_sa334"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MTOR associated protein LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 GENECARDS:MLST8 REACTOME:355793 KEGG:64223 WIKI:MLST8 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:12408816 References_end</body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="5849.5" y="1665.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s791_akt1_akt1_sa335"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: AKT1 substrate 1 (proline-rich) HUGO:AKT1S1 HGNC:28426 ENTREZ:84335 UNIPROT:Q96B36 GENECARDS:AKT1S1 REACTOME:200146 KEGG:84335 ATLASONC:GC_AKT1S1 WIKI:AKT1S1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18372248 PMID:17604271 References_end</body> </html> </notes> <label text="PRAS40*"/> <bbox w="160.0" h="57.0" x="5853.25" y="1603.0"/> <glyph class="state variable" id="_2584590f-fda6-48b9-820d-a1560f08b564"> <state value="" variable="S183"/> <bbox w="30.0" h="10.0" x="5839.235" y="1598.0"/> </glyph> <glyph class="state variable" id="_74fc731d-ccfc-44bd-b076-8635a5b2fa75"> <state value="" variable="T246"/> <bbox w="30.0" h="10.0" x="5838.25" y="1649.4719"/> </glyph> <glyph class="state variable" id="_a69efe8e-de0d-4631-8464-b5b323ae31b1"> <state value="" variable="S212"/> <bbox w="30.0" h="10.0" x="5998.25" y="1599.4121"/> </glyph> <glyph class="state variable" id="_963d9774-32ba-4ab1-a56c-c62f4c020e17"> <state value="" variable="S221"/> <bbox w="30.0" h="10.0" x="5998.25" y="1653.7612"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s787_akt1_akt1_sa519"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <bbox w="80.0" h="40.0" x="5936.5" y="1664.0"/> <glyph class="state variable" id="_2da53dab-3bcd-46bf-ae0d-952eb651548f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5931.5" y="1679.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s879_akt1_akt1_csa24" compartmentRef="akt1_akt1_c4_akt1_akt1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MLST8:MTOR:PRAS40*:RAC1:RPTOR Identifiers_end</body> </html> </notes> <label text="(mTORC1)"/> <bbox w="180.0" h="252.0" x="6045.6597" y="1599.0"/> <glyph class="macromolecule" id="akt1_akt1_s498_akt1_akt1_sa141"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: AKT1 substrate 1 (proline-rich) HUGO:AKT1S1 HGNC:28426 ENTREZ:84335 UNIPROT:Q96B36 GENECARDS:AKT1S1 REACTOME:200146 KEGG:84335 ATLASONC:GC_AKT1S1 WIKI:AKT1S1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18372248 PMID:17604271 References_end</body> </html> </notes> <label text="PRAS40*"/> <bbox w="160.0" h="57.0" x="6055.6597" y="1610.0"/> <glyph class="state variable" id="_f94eb38c-212b-4490-b5d3-820a23f46316"> <state value="" variable="S183"/> <bbox w="30.0" h="10.0" x="6041.6445" y="1605.0"/> </glyph> <glyph class="state variable" id="_c2a865eb-e952-4e98-87db-bc7523c917b3"> <state value="" variable="T246"/> <bbox w="30.0" h="10.0" x="6040.6597" y="1656.4719"/> </glyph> <glyph class="state variable" id="_8b188467-5d3b-49a5-b299-a13e32db7eb2"> <state value="" variable="S212"/> <bbox w="30.0" h="10.0" x="6200.6597" y="1606.4121"/> </glyph> <glyph class="state variable" id="_bf6fa210-67c5-48aa-825f-babb1452d924"> <state value="" variable="S221"/> <bbox w="30.0" h="10.0" x="6200.6597" y="1660.7612"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s497_akt1_akt1_sa144"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MTOR associated protein LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 GENECARDS:MLST8 REACTOME:355793 KEGG:64223 WIKI:MLST8 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:12408816 References_end</body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="6054.1597" y="1668.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s496_akt1_akt1_sa145"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: regulatory associated protein of MTOR complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 GENECARDS:RPTOR REACTOME:153287 KEGG:57521 ATLASONC:GC_RPTOR WIKI:RPTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19864431 PMID:12150925 PMID:15755954 References_end</body> </html> </notes> <label text="RPTOR"/> <bbox w="169.0" h="51.0" x="6053.1597" y="1713.5"/> <glyph class="state variable" id="_0031b94b-14ce-4992-a487-5354dc49a5dc"> <state value="" variable="S696"/> <bbox w="30.0" h="10.0" x="6038.1597" y="1733.9594"/> </glyph> <glyph class="state variable" id="_0b535cb5-4856-4384-9929-768960d2ebdc"> <state value="" variable="T706"/> <bbox w="30.0" h="10.0" x="6079.8213" y="1708.5"/> </glyph> <glyph class="state variable" id="_ab8d0444-3499-4d5e-85a2-0bcfe4145792"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="6158.465" y="1708.5"/> </glyph> <glyph class="state variable" id="_8948a955-7273-4d23-8017-ac692808d455"> <state value="" variable="S863"/> <bbox w="30.0" h="10.0" x="6158.148" y="1759.5"/> </glyph> <glyph class="state variable" id="_b376dec1-643c-4d8e-9dc4-90dc5c737644"> <state value="" variable="S877"/> <bbox w="30.0" h="10.0" x="6082.632" y="1759.5"/> </glyph> <glyph class="state variable" id="_0d4749ed-ca25-4d12-bf22-8f7de8c9e395"> <state value="" variable="S859"/> <bbox w="30.0" h="10.0" x="6207.1597" y="1731.1836"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s793_akt1_akt1_sa146"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 GENECARDS:MTOR REACTOME:54978 KEGG:2475 ATLASONC:FRAP1ID40639ch1p36 WIKI:MTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19568798 PMID:17680028 PMID:21157483 References_end</body> </html> </notes> <label text="MTOR"/> <bbox w="171.0" h="59.0" x="6052.1597" y="1775.0"/> <glyph class="state variable" id="_67514e8e-e29a-4459-ad46-90fc8ad2d969"> <state value="" variable="S1261"/> <bbox w="35.0" h="10.0" x="6042.2153" y="1770.0"/> </glyph> <glyph class="state variable" id="_c1314fe4-909a-4849-96ca-d95ae8bfec4c"> <state value="" variable="T2446"/> <bbox w="35.0" h="10.0" x="6198.3535" y="1770.0"/> </glyph> <glyph class="state variable" id="_55bf8e42-3ca9-4b94-bfd5-9180e7fde717"> <state value="" variable="S2448"/> <bbox w="35.0" h="10.0" x="6204.3384" y="1829.0"/> </glyph> <glyph class="state variable" id="_34036466-1f9f-4edd-af73-fefbf77a092c"> <state value="" variable="S2481"/> <bbox w="35.0" h="10.0" x="6034.6597" y="1827.4491"/> </glyph> <glyph class="state variable" id="_c1c5e088-1860-44ac-8681-2979dc7d9b60"> <state value="" variable="Y631"/> <bbox w="30.0" h="10.0" x="6037.1597" y="1799.5"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s801_akt1_akt1_sa520"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <bbox w="80.0" h="40.0" x="6136.5" y="1668.0"/> <glyph class="state variable" id="_fa0835fb-b51a-4d5a-be2e-5fb73e9a98a1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6131.5" y="1683.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s880_akt1_akt1_csa28" compartmentRef="akt1_akt1_c4_akt1_akt1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MLST8:MTOR:PRAS40*:RAC1:RPTOR Identifiers_end References_begin: s_akt1_re54(MAP:survival): PMID:10702316 PMID:19244117 References_end</body> </html> </notes> <label text="(mTORC1)"/> <bbox w="175.0" h="249.0" x="6244.8193" y="1596.0"/> <glyph class="macromolecule" id="akt1_akt1_s227_akt1_akt1_sa165"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: AKT1 substrate 1 (proline-rich) HUGO:AKT1S1 HGNC:28426 ENTREZ:84335 UNIPROT:Q96B36 GENECARDS:AKT1S1 REACTOME:200146 KEGG:84335 ATLASONC:GC_AKT1S1 WIKI:AKT1S1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18372248 PMID:17604271 References_end</body> </html> </notes> <label text="PRAS40*"/> <bbox w="156.0" h="55.0" x="6253.8193" y="1603.0"/> <glyph class="state variable" id="_7ff9228c-06d7-49c9-b3f1-e1024bf150a4"> <state value="" variable="S183"/> <bbox w="30.0" h="10.0" x="6239.78" y="1598.0"/> </glyph> <glyph class="state variable" id="_f6d91c96-5192-47c7-96d2-e80a60438891"> <state value="" variable="T246"/> <bbox w="30.0" h="10.0" x="6238.8193" y="1647.6659"/> </glyph> <glyph class="state variable" id="_1aff35bd-b83e-4450-9952-ac6cb8b89869"> <state value="" variable="S212"/> <bbox w="30.0" h="10.0" x="6394.8193" y="1599.3625"/> </glyph> <glyph class="state variable" id="_5c53fb08-89b8-4714-b685-06df155481c8"> <state value="" variable="S221"/> <bbox w="30.0" h="10.0" x="6394.8193" y="1651.8047"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s228_akt1_akt1_sa166"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MTOR associated protein LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 GENECARDS:MLST8 REACTOME:355793 KEGG:64223 WIKI:MLST8 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:12408816 References_end</body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="6249.3193" y="1665.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s229_akt1_akt1_sa167"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: regulatory associated protein of MTOR complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 GENECARDS:RPTOR REACTOME:153287 KEGG:57521 ATLASONC:GC_RPTOR WIKI:RPTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19864431 PMID:12150925 PMID:15755954 References_end</body> </html> </notes> <label text="RPTOR"/> <bbox w="164.0" h="44.0" x="6248.3193" y="1713.5"/> <glyph class="state variable" id="_80349f20-6035-4804-8916-b61f93587153"> <state value="" variable="S696"/> <bbox w="30.0" h="10.0" x="6233.3193" y="1730.465"/> </glyph> <glyph class="state variable" id="_c9322f98-ac42-4c2c-9d94-c4d17bf8831e"> <state value="" variable="T706"/> <bbox w="30.0" h="10.0" x="6273.748" y="1708.5"/> </glyph> <glyph class="state variable" id="_840a13a8-8468-4511-b7a6-f83fc203896a"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="6350.0654" y="1708.5"/> </glyph> <glyph class="state variable" id="_01f67de0-0045-4809-805c-7396925591f3"> <state value="" variable="S863"/> <bbox w="30.0" h="10.0" x="6349.758" y="1752.5"/> </glyph> <glyph class="state variable" id="_ab3aaf50-c64b-4125-a39b-b7feb54f6d30"> <state value="" variable="S877"/> <bbox w="30.0" h="10.0" x="6276.4756" y="1752.5"/> </glyph> <glyph class="state variable" id="_8cfe35e0-2ea5-4863-ad90-ada98fe51acb"> <state value="" variable="S859"/> <bbox w="30.0" h="10.0" x="6397.3193" y="1728.0702"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s794_akt1_akt1_sa168"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 GENECARDS:MTOR REACTOME:54978 KEGG:2475 ATLASONC:FRAP1ID40639ch1p36 WIKI:MTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19568798 PMID:17680028 PMID:21157483 References_end</body> </html> </notes> <label text="MTOR"/> <bbox w="161.0" h="63.0" x="6247.3193" y="1766.0"/> <glyph class="state variable" id="_e6b5813f-5d30-4b18-aa25-65720a788525"> <state value="P" variable="S1261"/> <bbox w="40.0" h="10.0" x="6234.433" y="1761.0"/> </glyph> <glyph class="state variable" id="_5ff81cdf-6348-441c-9a14-82c3a6274cf2"> <state value="" variable="T2446"/> <bbox w="35.0" h="10.0" x="6383.9404" y="1761.0"/> </glyph> <glyph class="state variable" id="_d881e7a4-3e8d-4ce9-acaa-3d3c20f751be"> <state value="" variable="S2448"/> <bbox w="35.0" h="10.0" x="6389.575" y="1824.0"/> </glyph> <glyph class="state variable" id="_ad6fdf0c-8e26-4594-b1fc-894c0bcc1f51"> <state value="" variable="S2481"/> <bbox w="35.0" h="10.0" x="6229.8193" y="1822.3439"/> </glyph> <glyph class="state variable" id="_647ad181-b9b8-4e78-b61a-a9858e4aee7b"> <state value="" variable="Y631"/> <bbox w="30.0" h="10.0" x="6232.3193" y="1792.5"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s802_akt1_akt1_sa521"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <bbox w="80.0" h="40.0" x="6332.5" y="1665.0"/> <glyph class="state variable" id="_5642b09b-660f-4bd4-869b-c83a1003b9cd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6327.5" y="1680.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s881_akt1_akt1_csa29" compartmentRef="akt1_akt1_c4_akt1_akt1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MLST8:MTOR:PRAS40*:RAC1:RPTOR Identifiers_end References_begin: s_akt1_re54(MAP:survival): PMID:10702316 PMID:19244117 s_akt1_re55(MAP:survival): PMID:19864431 PMID:12150925 PMID:15755954 References_end</body> </html> </notes> <label text="(mTORC1)"/> <bbox w="166.0" h="245.0" x="6442.3403" y="1596.0"/> <glyph class="macromolecule" id="akt1_akt1_s237_akt1_akt1_sa169"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: AKT1 substrate 1 (proline-rich) HUGO:AKT1S1 HGNC:28426 ENTREZ:84335 UNIPROT:Q96B36 GENECARDS:AKT1S1 REACTOME:200146 KEGG:84335 ATLASONC:GC_AKT1S1 WIKI:AKT1S1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18372248 PMID:17604271 References_end</body> </html> </notes> <label text="PRAS40*"/> <bbox w="150.0" h="44.0" x="6449.3403" y="1606.0"/> <glyph class="state variable" id="_b84f062f-9b07-439f-91ae-3fb98bd79505"> <state value="" variable="S183"/> <bbox w="30.0" h="10.0" x="6435.2637" y="1601.0"/> </glyph> <glyph class="state variable" id="_48d1d251-eb13-4cc4-8e43-3b06b7786030"> <state value="" variable="T246"/> <bbox w="30.0" h="10.0" x="6434.3403" y="1640.7327"/> </glyph> <glyph class="state variable" id="_37a23c54-1b6c-4ad3-b7e4-6b9a80d3da58"> <state value="" variable="S212"/> <bbox w="30.0" h="10.0" x="6584.3403" y="1602.0901"/> </glyph> <glyph class="state variable" id="_d5e803ab-929a-4553-9a88-f20a3908effc"> <state value="" variable="S221"/> <bbox w="30.0" h="10.0" x="6584.3403" y="1644.0437"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s238_akt1_akt1_sa170"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MTOR associated protein LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 GENECARDS:MLST8 REACTOME:355793 KEGG:64223 WIKI:MLST8 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:12408816 References_end</body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="6449.8403" y="1652.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s239_akt1_akt1_sa171"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: regulatory associated protein of MTOR complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 GENECARDS:RPTOR REACTOME:153287 KEGG:57521 ATLASONC:GC_RPTOR WIKI:RPTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19864431 PMID:12150925 PMID:15755954 References_end</body> </html> </notes> <label text="RPTOR"/> <bbox w="150.0" h="53.0" x="6450.8403" y="1693.5"/> <glyph class="state variable" id="_4c36ab91-2c97-4ab8-ae8f-e98462c5baf4"> <state value="" variable="S696"/> <bbox w="30.0" h="10.0" x="6435.8403" y="1714.9578"/> </glyph> <glyph class="state variable" id="_59e6dddb-ef4a-4c25-a02d-ff2daa42eaea"> <state value="" variable="T706"/> <bbox w="30.0" h="10.0" x="6472.818" y="1688.5"/> </glyph> <glyph class="state variable" id="_c938b279-68aa-4bcc-810e-378c0a880531"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="6542.62" y="1688.5"/> </glyph> <glyph class="state variable" id="_0363c0f1-c14c-4a6b-b257-5ee1e308945e"> <state value="" variable="S863"/> <bbox w="30.0" h="10.0" x="6542.339" y="1741.5"/> </glyph> <glyph class="state variable" id="_c08d987a-e835-49c8-ab00-8d23f59ad637"> <state value="" variable="S877"/> <bbox w="30.0" h="10.0" x="6475.3125" y="1741.5"/> </glyph> <glyph class="state variable" id="_a11a6d1b-76d2-424c-91f7-674054864ee4"> <state value="" variable="S859"/> <bbox w="30.0" h="10.0" x="6585.8403" y="1712.0732"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s795_akt1_akt1_sa172"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 GENECARDS:MTOR REACTOME:54978 KEGG:2475 ATLASONC:FRAP1ID40639ch1p36 WIKI:MTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19568798 PMID:17680028 PMID:21157483 References_end</body> </html> </notes> <label text="MTOR"/> <bbox w="152.0" h="62.0" x="6446.8403" y="1756.0"/> <glyph class="state variable" id="_be0f4e90-e206-42b9-a627-cac2e4451c3c"> <state value="P" variable="S1261"/> <bbox w="40.0" h="10.0" x="6433.5566" y="1751.0"/> </glyph> <glyph class="state variable" id="_37e488bf-88e0-49dc-808a-b480911f21d5"> <state value="" variable="T2446"/> <bbox w="35.0" h="10.0" x="6574.846" y="1751.0"/> </glyph> <glyph class="state variable" id="_cd4296be-ea57-45e7-83be-6144c9eb2a06"> <state value="" variable="S2448"/> <bbox w="35.0" h="10.0" x="6580.1655" y="1813.0"/> </glyph> <glyph class="state variable" id="_f446a6a6-3ed9-4964-bf7f-d3526adca6da"> <state value="P" variable="S2481"/> <bbox w="40.0" h="10.0" x="6426.8403" y="1811.3701"/> </glyph> <glyph class="state variable" id="_159550bc-f4d3-4816-9bcc-e926da6da729"> <state value="" variable="Y631"/> <bbox w="30.0" h="10.0" x="6431.8403" y="1782.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s803_akt1_akt1_sa522"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <bbox w="80.0" h="40.0" x="6522.5" y="1651.0"/> <glyph class="state variable" id="_fe0dc23e-c28f-4145-a8dc-b3ffbe71d77d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6517.5" y="1666.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s882_akt1_akt1_csa31" compartmentRef="akt1_akt1_c4_akt1_akt1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MLST8:MTOR:PRAS40*:RAC1:RPTOR Identifiers_end References_begin: s_akt1_re57(MAP:survival): PMID:18372248 PMID:20138985 s_akt1_re58(MAP:survival): PMID:19446321 ANNOTATION:complex formation with DEPTOR antagonize/inhibits MTOR kinase activity PMID:19706736 References_end</body> </html> </notes> <label text="(mTORC1)"/> <bbox w="171.0" h="240.0" x="6372.6387" y="1898.0"/> <glyph class="macromolecule" id="akt1_akt1_s261_akt1_akt1_sa178"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MTOR associated protein LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 GENECARDS:MLST8 REACTOME:355793 KEGG:64223 WIKI:MLST8 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:12408816 References_end</body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="6375.1387" y="1957.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s262_akt1_akt1_sa179"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: regulatory associated protein of MTOR complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 GENECARDS:RPTOR REACTOME:153287 KEGG:57521 ATLASONC:GC_RPTOR WIKI:RPTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19864431 PMID:12150925 PMID:15755954 References_end</body> </html> </notes> <label text="RPTOR"/> <bbox w="140.0" h="46.0" x="6389.1387" y="1998.5"/> <glyph class="state variable" id="_2b5090d2-458b-433f-ad2b-27b32cf24671"> <state value="P" variable="S696"/> <bbox w="35.0" h="10.0" x="6371.6387" y="2016.4634"/> </glyph> <glyph class="state variable" id="_fc98de74-847e-4100-a548-a6bf46503f59"> <state value="P" variable="T706"/> <bbox w="35.0" h="10.0" x="6406.1514" y="1993.5"/> </glyph> <glyph class="state variable" id="_0eb9dca0-6284-4016-9693-6cfab059e79d"> <state value="P" variable="S855"/> <bbox w="35.0" h="10.0" x="6471.3" y="1993.5"/> </glyph> <glyph class="state variable" id="_aa72ae88-8aae-4b14-b758-8032c9794f15"> <state value="P" variable="S863"/> <bbox w="35.0" h="10.0" x="6471.037" y="2039.5"/> </glyph> <glyph class="state variable" id="_dee6299d-0f2d-4881-a68f-a591d9de2063"> <state value="P" variable="S877"/> <bbox w="35.0" h="10.0" x="6408.4795" y="2039.5"/> </glyph> <glyph class="state variable" id="_aa3109e8-8cb7-468e-b5eb-757548183e64"> <state value="P" variable="S859"/> <bbox w="35.0" h="10.0" x="6511.6387" y="2013.9597"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s798_akt1_akt1_sa180"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 GENECARDS:MTOR REACTOME:54978 KEGG:2475 ATLASONC:FRAP1ID40639ch1p36 WIKI:MTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19568798 PMID:17680028 PMID:21157483 References_end</body> </html> </notes> <label text="MTOR"/> <bbox w="163.0" h="64.0" x="6376.1387" y="2053.0"/> <glyph class="state variable" id="_77d81a3c-5fa8-4901-8daa-ca7beaacff2b"> <state value="P" variable="S1261"/> <bbox w="40.0" h="10.0" x="6363.341" y="2048.0"/> </glyph> <glyph class="state variable" id="_9cb36a45-f3eb-4cce-bf72-1e38614449a7"> <state value="" variable="T2446"/> <bbox w="35.0" h="10.0" x="6514.675" y="2048.0"/> </glyph> <glyph class="state variable" id="_93a893ac-5764-45f4-bc17-c4203e960464"> <state value="" variable="S2448"/> <bbox w="35.0" h="10.0" x="6520.379" y="2112.0"/> </glyph> <glyph class="state variable" id="_1ab6242b-6cc9-487d-be90-747077992c58"> <state value="P" variable="S2481"/> <bbox w="40.0" h="10.0" x="6356.1387" y="2110.3176"/> </glyph> <glyph class="state variable" id="_1089cc16-c759-4297-9f39-f80df47d5e18"> <state value="" variable="Y631"/> <bbox w="30.0" h="10.0" x="6361.1387" y="2080.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s267_akt1_akt1_sa181"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: AKT1 substrate 1 (proline-rich) HUGO:AKT1S1 HGNC:28426 ENTREZ:84335 UNIPROT:Q96B36 GENECARDS:AKT1S1 REACTOME:200146 KEGG:84335 ATLASONC:GC_AKT1S1 WIKI:AKT1S1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18372248 PMID:17604271 References_end</body> </html> </notes> <label text="PRAS40*"/> <bbox w="151.0" h="47.0" x="6384.3887" y="1906.0"/> <glyph class="state variable" id="_d25771f4-e1f7-4018-9121-ea17c38ab276"> <state value="P" variable="S183"/> <bbox w="35.0" h="10.0" x="6367.8184" y="1901.0"/> </glyph> <glyph class="state variable" id="_395e1509-98f3-40d1-8aa8-fa5199ce0532"> <state value="P" variable="T246"/> <bbox w="35.0" h="10.0" x="6366.8887" y="1943.4418"/> </glyph> <glyph class="state variable" id="_021951d7-68a9-46cd-9e4f-5764da7fca35"> <state value="P" variable="S212"/> <bbox w="35.0" h="10.0" x="6517.8887" y="1902.1644"/> </glyph> <glyph class="state variable" id="_01737638-392a-44b2-84f6-8ed72f4e979e"> <state value="P" variable="S221"/> <bbox w="35.0" h="10.0" x="6517.8887" y="1946.9785"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s806_akt1_akt1_sa525"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <bbox w="80.0" h="40.0" x="6457.5" y="1958.0"/> <glyph class="state variable" id="_3e9c484b-1de7-4b44-ad64-d99dccdba923"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6452.5" y="1973.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s883_akt1_akt1_csa32" compartmentRef="akt1_akt1_c4_akt1_akt1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MLST8:MTOR:RAC1:RPTOR Identifiers_end References_begin: s_akt1_re58(MAP:survival): PMID:19446321 ANNOTATION:complex formation with DEPTOR antagonize/inhibits MTOR kinase activity PMID:19706736 s_akt1_re202:(MAP:survival) PMID:19225151 References_end</body> </html> </notes> <label text="(mTORC1)"/> <bbox w="171.0" h="240.0" x="6093.8193" y="1892.5"/> <glyph class="macromolecule" id="akt1_akt1_s319_akt1_akt1_sa182"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MTOR associated protein LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 GENECARDS:MLST8 REACTOME:355793 KEGG:64223 WIKI:MLST8 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:12408816 References_end</body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="6131.3193" y="1946.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s320_akt1_akt1_sa183"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: regulatory associated protein of MTOR complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 GENECARDS:RPTOR REACTOME:153287 KEGG:57521 ATLASONC:GC_RPTOR WIKI:RPTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19864431 PMID:12150925 PMID:15755954 References_end</body> </html> </notes> <label text="RPTOR"/> <bbox w="140.0" h="46.0" x="6110.3193" y="1993.0"/> <glyph class="state variable" id="_06d1d44f-c7d7-433d-a6c8-bffbde2037a3"> <state value="P" variable="S696"/> <bbox w="35.0" h="10.0" x="6092.8193" y="2010.9634"/> </glyph> <glyph class="state variable" id="_98aedf66-92e5-433b-a73c-8ffa9e4d9eaf"> <state value="P" variable="T706"/> <bbox w="35.0" h="10.0" x="6127.332" y="1988.0"/> </glyph> <glyph class="state variable" id="_da6fab67-b6a4-4860-8969-a62d1f8a684b"> <state value="P" variable="S855"/> <bbox w="35.0" h="10.0" x="6192.4805" y="1988.0"/> </glyph> <glyph class="state variable" id="_597a5294-2205-4554-ae1d-ec2c88e9ed2e"> <state value="P" variable="S863"/> <bbox w="35.0" h="10.0" x="6192.218" y="2034.0"/> </glyph> <glyph class="state variable" id="_aef6ec9d-329f-4ac1-a5fa-41aac04dffc9"> <state value="P" variable="S877"/> <bbox w="35.0" h="10.0" x="6129.66" y="2034.0"/> </glyph> <glyph class="state variable" id="_ab947ae4-6fa3-4c5e-8274-4d986524dbc7"> <state value="P" variable="S859"/> <bbox w="35.0" h="10.0" x="6232.8193" y="2008.4597"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s799_akt1_akt1_sa184"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 GENECARDS:MTOR REACTOME:54978 KEGG:2475 ATLASONC:FRAP1ID40639ch1p36 WIKI:MTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19568798 PMID:17680028 PMID:21157483 References_end</body> </html> </notes> <label text="MTOR"/> <bbox w="160.0" h="62.0" x="6099.3193" y="2047.5"/> <glyph class="state variable" id="_144e8107-e651-45c7-bab0-db321d118387"> <state value="P" variable="S1261"/> <bbox w="40.0" h="10.0" x="6086.389" y="2042.5"/> </glyph> <glyph class="state variable" id="_5a47676a-74f6-465c-ae62-1146e7f32bf1"> <state value="" variable="T2446"/> <bbox w="35.0" h="10.0" x="6234.9834" y="2042.5"/> </glyph> <glyph class="state variable" id="_4fc6cef0-c9ff-467a-be81-e669110b7304"> <state value="" variable="S2448"/> <bbox w="35.0" h="10.0" x="6240.583" y="2104.5"/> </glyph> <glyph class="state variable" id="_1010996b-8084-4a42-8be8-917c8125d51c"> <state value="P" variable="S2481"/> <bbox w="40.0" h="10.0" x="6079.3193" y="2102.87"/> </glyph> <glyph class="state variable" id="_e9b76587-d448-4761-a92b-b66ea576e95b"> <state value="" variable="Y631"/> <bbox w="30.0" h="10.0" x="6084.3193" y="2073.5"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s807_akt1_akt1_sa526"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <bbox w="80.0" h="40.0" x="6133.5" y="1904.0"/> <glyph class="state variable" id="_7ca77492-387f-442c-a2bb-30f384b2db3e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6128.5" y="1919.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s884_akt1_akt1_csa34" compartmentRef="akt1_akt1_c4_akt1_akt1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DEPTOR:MLST8:MTOR:RAC1:RPTOR Identifiers_end References_begin: s_akt1_re58(MAP:survival): PMID:19446321 ANNOTATION:complex formation with DEPTOR antagonize/inhibits MTOR kinase activity PMID:19706736 References_end</body> </html> </notes> <label text="(mTORC1)"/> <bbox w="171.0" h="240.0" x="5844.9688" y="1891.0"/> <glyph class="macromolecule" id="akt1_akt1_s286_akt1_akt1_sa190"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MTOR associated protein LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 GENECARDS:MLST8 REACTOME:355793 KEGG:64223 WIKI:MLST8 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:12408816 References_end</body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="5848.4688" y="1902.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s287_akt1_akt1_sa191"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: regulatory associated protein of MTOR complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 GENECARDS:RPTOR REACTOME:153287 KEGG:57521 ATLASONC:GC_RPTOR WIKI:RPTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19864431 PMID:12150925 PMID:15755954 References_end</body> </html> </notes> <label text="RPTOR"/> <bbox w="140.0" h="46.0" x="5861.4688" y="1947.5"/> <glyph class="state variable" id="_c17e40cd-fdb3-4580-84cc-55bb3ccd477d"> <state value="P" variable="S696"/> <bbox w="35.0" h="10.0" x="5843.9688" y="1965.4634"/> </glyph> <glyph class="state variable" id="_39e6c888-29c5-48ad-a2da-71513119d638"> <state value="P" variable="T706"/> <bbox w="35.0" h="10.0" x="5878.4814" y="1942.5"/> </glyph> <glyph class="state variable" id="_33644368-9de1-43de-8596-b3cecae95fb5"> <state value="P" variable="S855"/> <bbox w="35.0" h="10.0" x="5943.63" y="1942.5"/> </glyph> <glyph class="state variable" id="_500efe2d-d714-4919-9bd8-265162965229"> <state value="P" variable="S863"/> <bbox w="35.0" h="10.0" x="5943.367" y="1988.5"/> </glyph> <glyph class="state variable" id="_7eddee99-9c00-4c09-85f4-e68fc78f1e3c"> <state value="P" variable="S877"/> <bbox w="35.0" h="10.0" x="5880.8096" y="1988.5"/> </glyph> <glyph class="state variable" id="_9beb9d75-1896-43b4-bb90-80260b0c66cc"> <state value="P" variable="S859"/> <bbox w="35.0" h="10.0" x="5983.9688" y="1962.9597"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s800_akt1_akt1_sa192"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 GENECARDS:MTOR REACTOME:54978 KEGG:2475 ATLASONC:FRAP1ID40639ch1p36 WIKI:MTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19568798 PMID:17680028 PMID:21157483 References_end</body> </html> </notes> <label text="MTOR"/> <bbox w="160.0" h="62.0" x="5850.4688" y="2002.0"/> <glyph class="state variable" id="_7e44f373-91e0-4946-b0ca-3a663cf29d5c"> <state value="P" variable="S1261"/> <bbox w="40.0" h="10.0" x="5837.5386" y="1997.0"/> </glyph> <glyph class="state variable" id="_c7d4cf50-8b78-45cb-841e-a37401701c9d"> <state value="" variable="T2446"/> <bbox w="35.0" h="10.0" x="5986.133" y="1997.0"/> </glyph> <glyph class="state variable" id="_f4a304e4-7fb8-42fe-9b84-425e020911ba"> <state value="" variable="S2448"/> <bbox w="35.0" h="10.0" x="5991.7324" y="2059.0"/> </glyph> <glyph class="state variable" id="_5b0faccd-cf2d-41a9-a573-d8e6dd859846"> <state value="P" variable="S2481"/> <bbox w="40.0" h="10.0" x="5830.4688" y="2057.37"/> </glyph> <glyph class="state variable" id="_e617ece4-e12b-4140-9c86-fd47db9b6ab0"> <state value="" variable="Y631"/> <bbox w="30.0" h="10.0" x="5835.4688" y="2028.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s284_akt1_akt1_sa199"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DEP domain containing MTOR-interacting protein HUGO:DEPTOR HGNC:22953 ENTREZ:64798 UNIPROT:Q8TB45 GENECARDS:DEPTOR KEGG:64798 ATLASONC:GC_DEPTOR WIKI:DEPTOR Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19446321 PMID:19706736 References_end</body> </html> </notes> <label text="DEPTOR"/> <bbox w="80.0" h="40.0" x="5891.5" y="2067.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s808_akt1_akt1_sa527"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <bbox w="80.0" h="40.0" x="5930.5" y="1903.0"/> <glyph class="state variable" id="_10f36290-b444-4df8-9657-24ccfc6186e7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5925.5" y="1918.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s885_akt1_akt1_csa25" compartmentRef="akt1_akt1_c4_akt1_akt1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MLST8:MTOR:PRAS40*:RAC1:RPTOR Identifiers_end References_begin: s_akt1_re55(MAP:survival): PMID:19864431 PMID:12150925 PMID:15755954 References_end</body> </html> </notes> <label text="(mTORC1)"/> <bbox w="171.0" h="240.0" x="6630.5" y="1596.0"/> <glyph class="macromolecule" id="akt1_akt1_s275_akt1_akt1_sa150"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MTOR associated protein LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 GENECARDS:MLST8 REACTOME:355793 KEGG:64223 WIKI:MLST8 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:12408816 References_end</body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="6635.0" y="1651.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s244_akt1_akt1_sa151"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: regulatory associated protein of MTOR complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 GENECARDS:RPTOR REACTOME:153287 KEGG:57521 ATLASONC:GC_RPTOR WIKI:RPTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19864431 PMID:12150925 PMID:15755954 References_end</body> </html> </notes> <label text="RPTOR"/> <bbox w="140.0" h="46.0" x="6649.0" y="1695.5"/> <glyph class="state variable" id="_3237de92-a7fe-49cd-b3fb-734be3164e39"> <state value="P" variable="S696"/> <bbox w="35.0" h="10.0" x="6631.5" y="1713.4634"/> </glyph> <glyph class="state variable" id="_dea37efe-0b72-40b1-aa2c-d60a55614e1b"> <state value="P" variable="T706"/> <bbox w="35.0" h="10.0" x="6666.0127" y="1690.5"/> </glyph> <glyph class="state variable" id="_9a953a4b-de6e-4e7e-9122-501b9347dc27"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="6733.661" y="1690.5"/> </glyph> <glyph class="state variable" id="_bae53beb-674a-42fa-a438-278002b91d4e"> <state value="P" variable="S863"/> <bbox w="35.0" h="10.0" x="6730.8984" y="1736.5"/> </glyph> <glyph class="state variable" id="_13aa4eae-82a7-4ccf-8f72-b19043193abf"> <state value="P" variable="S877"/> <bbox w="35.0" h="10.0" x="6668.341" y="1736.5"/> </glyph> <glyph class="state variable" id="_2ac5e5ca-09be-4aa6-8658-f9cb29692e2c"> <state value="" variable="S859"/> <bbox w="30.0" h="10.0" x="6774.0" y="1710.9597"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s796_akt1_akt1_sa152"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 GENECARDS:MTOR REACTOME:54978 KEGG:2475 ATLASONC:FRAP1ID40639ch1p36 WIKI:MTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19568798 PMID:17680028 PMID:21157483 References_end</body> </html> </notes> <label text="MTOR"/> <bbox w="162.0" h="66.0" x="6634.0" y="1751.0"/> <glyph class="state variable" id="_42ae661d-d783-434e-9ad8-3b17dec1a13f"> <state value="P" variable="S1261"/> <bbox w="40.0" h="10.0" x="6621.158" y="1746.0"/> </glyph> <glyph class="state variable" id="_f481ce35-3351-4a0f-a780-e7936c03f007"> <state value="" variable="T2446"/> <bbox w="35.0" h="10.0" x="6771.5786" y="1746.0"/> </glyph> <glyph class="state variable" id="_fc9af15b-d919-407f-a9f8-8e2fc2073487"> <state value="" variable="S2448"/> <bbox w="35.0" h="10.0" x="6777.248" y="1812.0"/> </glyph> <glyph class="state variable" id="_e5384930-1442-4422-8a33-80b1d0f02837"> <state value="P" variable="S2481"/> <bbox w="40.0" h="10.0" x="6614.0" y="1810.265"/> </glyph> <glyph class="state variable" id="_f9668010-299f-4334-bca1-e395084cc3c0"> <state value="" variable="Y631"/> <bbox w="30.0" h="10.0" x="6619.0" y="1779.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s257_akt1_akt1_sa153"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: AKT1 substrate 1 (proline-rich) HUGO:AKT1S1 HGNC:28426 ENTREZ:84335 UNIPROT:Q96B36 GENECARDS:AKT1S1 REACTOME:200146 KEGG:84335 ATLASONC:GC_AKT1S1 WIKI:AKT1S1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18372248 PMID:17604271 References_end</body> </html> </notes> <label text="PRAS40*"/> <bbox w="154.0" h="40.0" x="6638.0" y="1607.0"/> <glyph class="state variable" id="_87957467-176e-4054-aa73-72686b79ae1d"> <state value="" variable="S183"/> <bbox w="30.0" h="10.0" x="6623.948" y="1602.0"/> </glyph> <glyph class="state variable" id="_92005fa9-dad2-44aa-913d-77a77c277dfe"> <state value="" variable="T246"/> <bbox w="30.0" h="10.0" x="6623.0" y="1638.1206"/> </glyph> <glyph class="state variable" id="_f17fa9f5-d274-49ee-8612-6b2a446b4775"> <state value="" variable="S212"/> <bbox w="30.0" h="10.0" x="6777.0" y="1602.991"/> </glyph> <glyph class="state variable" id="_14fce587-137e-4734-a0b9-6567e701c983"> <state value="" variable="S221"/> <bbox w="30.0" h="10.0" x="6777.0" y="1641.1306"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s804_akt1_akt1_sa523"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <bbox w="80.0" h="40.0" x="6718.5" y="1651.0"/> <glyph class="state variable" id="_b44689ac-afa0-4963-ae46-79823714f1e3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6713.5" y="1666.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s886_akt1_akt1_csa30" compartmentRef="akt1_akt1_c4_akt1_akt1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MLST8:MTOR:PRAS40*:RAC1:RPTOR Identifiers_end References_begin: s_akt1_re56(MAP:survival): PMID:19864431 PMID:12150925 PMID:15755954 s_akt1_re57(MAP:survival): PMID:18372248 PMID:20138985 References_end</body> </html> </notes> <label text="(mTORC1)"/> <bbox w="171.0" h="240.0" x="6632.75" y="1895.0"/> <glyph class="macromolecule" id="akt1_akt1_s246_akt1_akt1_sa173"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MTOR associated protein LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 GENECARDS:MLST8 REACTOME:355793 KEGG:64223 WIKI:MLST8 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:12408816 References_end</body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="6645.25" y="1952.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s250_akt1_akt1_sa174"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: regulatory associated protein of MTOR complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 GENECARDS:RPTOR REACTOME:153287 KEGG:57521 ATLASONC:GC_RPTOR WIKI:RPTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19864431 PMID:12150925 PMID:15755954 References_end</body> </html> </notes> <label text="RPTOR"/> <bbox w="140.0" h="46.0" x="6649.25" y="1995.5"/> <glyph class="state variable" id="_2e439f1e-e997-4289-80ee-15b4de58905c"> <state value="P" variable="S696"/> <bbox w="35.0" h="10.0" x="6631.75" y="2013.4634"/> </glyph> <glyph class="state variable" id="_212286f9-0bfa-48f3-9a26-81c1d09731ce"> <state value="P" variable="T706"/> <bbox w="35.0" h="10.0" x="6666.2627" y="1990.5"/> </glyph> <glyph class="state variable" id="_e5792fc7-3c0d-4cc9-acd7-1166d1cb1aa1"> <state value="P" variable="S855"/> <bbox w="35.0" h="10.0" x="6731.411" y="1990.5"/> </glyph> <glyph class="state variable" id="_033c25db-4038-4a87-ad57-770cc7fd0e11"> <state value="P" variable="S863"/> <bbox w="35.0" h="10.0" x="6731.1484" y="2036.5"/> </glyph> <glyph class="state variable" id="_d444aa10-f0d2-4568-bf68-676c34855b3b"> <state value="P" variable="S877"/> <bbox w="35.0" h="10.0" x="6668.591" y="2036.5"/> </glyph> <glyph class="state variable" id="_6e3572a8-745f-4020-8c2f-bcbe98035d25"> <state value="P" variable="S859"/> <bbox w="35.0" h="10.0" x="6771.75" y="2010.9597"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s797_akt1_akt1_sa175"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 GENECARDS:MTOR REACTOME:54978 KEGG:2475 ATLASONC:FRAP1ID40639ch1p36 WIKI:MTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19568798 PMID:17680028 PMID:21157483 References_end</body> </html> </notes> <label text="MTOR"/> <bbox w="153.0" h="63.0" x="6642.25" y="2050.0"/> <glyph class="state variable" id="_5e220a71-ad20-4658-806e-81f65a524178"> <state value="P" variable="S1261"/> <bbox w="40.0" h="10.0" x="6629.0103" y="2045.0"/> </glyph> <glyph class="state variable" id="_401372fd-3736-4f50-ab9c-39fb2fe25a71"> <state value="" variable="T2446"/> <bbox w="35.0" h="10.0" x="6771.213" y="2045.0"/> </glyph> <glyph class="state variable" id="_907428c4-233d-49f5-af3a-aaed74e17a34"> <state value="" variable="S2448"/> <bbox w="35.0" h="10.0" x="6776.568" y="2108.0"/> </glyph> <glyph class="state variable" id="_1aa277d9-cfe6-4f97-b6f8-ab9d8d88ba88"> <state value="P" variable="S2481"/> <bbox w="40.0" h="10.0" x="6622.25" y="2106.344"/> </glyph> <glyph class="state variable" id="_d8f165f2-b27b-49e5-90b1-ada711c9e8c8"> <state value="" variable="Y631"/> <bbox w="30.0" h="10.0" x="6627.25" y="2076.5"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s259_akt1_akt1_sa176"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: AKT1 substrate 1 (proline-rich) HUGO:AKT1S1 HGNC:28426 ENTREZ:84335 UNIPROT:Q96B36 GENECARDS:AKT1S1 REACTOME:200146 KEGG:84335 ATLASONC:GC_AKT1S1 WIKI:AKT1S1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18372248 PMID:17604271 References_end</body> </html> </notes> <label text="PRAS40*"/> <bbox w="150.0" h="42.0" x="6641.5" y="1899.0"/> <glyph class="state variable" id="_1ed7dd50-0e3c-4519-a623-1a7736b10cfa"> <state value="" variable="S183"/> <bbox w="30.0" h="10.0" x="6627.4233" y="1894.0"/> </glyph> <glyph class="state variable" id="_01d3234e-5687-4dba-99fa-75a7dbb3dd88"> <state value="" variable="T246"/> <bbox w="30.0" h="10.0" x="6626.5" y="1931.9266"/> </glyph> <glyph class="state variable" id="_2bedbc11-ffc7-4116-95db-686781a6d3ae"> <state value="" variable="S212"/> <bbox w="30.0" h="10.0" x="6776.5" y="1895.0405"/> </glyph> <glyph class="state variable" id="_48275202-2a42-4eda-96ce-899b2a126a7a"> <state value="" variable="S221"/> <bbox w="30.0" h="10.0" x="6776.5" y="1935.0872"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s805_akt1_akt1_sa524"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <bbox w="80.0" h="40.0" x="6720.5" y="1949.0"/> <glyph class="state variable" id="_4c57a517-59b9-4318-98c0-2cc4988f176a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6715.5" y="1964.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s887_akt1_akt1_csa81" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PP2B_B*:PP2B_C* Identifiers_end References_begin: s_akt1_re24:(MAP:survival) PMID:18042541 PMID:18077353 References_end</body> </html> </notes> <label text="(PP2B)"/> <bbox w="100.0" h="120.0" x="6069.0" y="137.0"/> <glyph class="macromolecule" id="akt1_akt1_s749_akt1_akt1_sa497"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3 regulatory subunit B alpha HUGO:PPP3R1 HGNC:9317 ENTREZ:5534 UNIPROT:P63098 GENECARDS:PPP3R1 REACTOME:51292 KEGG:5534 ATLASONC:GC_PPP3R1 WIKI:PPP3R1 protein phosphatase 3 regulatory subunit B beta HUGO:PPP3R2 HGNC:9318 ENTREZ:5535 UNIPROT:Q96LZ3 GENECARDS:PPP3R2 KEGG:5535 ATLASONC:GC_PPP3R2 WIKI:PPP3R2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18249169 References_end</body> </html> </notes> <label text="PP2B_B*"/> <bbox w="80.0" h="40.0" x="6077.0" y="147.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s750_akt1_akt1_sa498"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3 catalytic subunit alpha isozyme HUGO:PPP3CA HGNC:9314 ENTREZ:5530 UNIPROT:Q08209 GENECARDS:PPP3CA REACTOME:61110 KEGG:5530 ATLASONC:GC_PPP3CA WIKI:PPP3CA protein phosphatase 3 catalytic subunit beta isozyme HUGO:PPP3CB HGNC:9315 ENTREZ:5532 UNIPROT:P16298 GENECARDS:PPP3CB REACTOME:403037 KEGG:5532 ATLASONC:GC_PPP3CB WIKI:PPP3CB protein phosphatase 3 catalytic subunit gamma isozyme HUGO:PPP3CC HGNC:9316 ENTREZ:5533 UNIPROT:P48454 GENECARDS:PPP3CC REACTOME:61114 KEGG:5533 ATLASONC:GC_PPP3CC WIKI:PPP3CC Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18249169 PMID:20673124 References_end</body> </html> </notes> <label text="PP2B_C*"/> <bbox w="80.0" h="40.0" x="6077.0" y="190.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt1_s888_akt1_akt1_csa17" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PP2A_A*:PP2A_B55_alpha_*:PP2A_C* Identifiers_end</body> </html> </notes> <label text="(PP2A)"/> <bbox w="105.0" h="150.0" x="5944.0" y="136.0"/> <glyph class="macromolecule" id="akt1_akt1_s106_akt1_akt1_sa89"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 References_end Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> </notes> <label text="PP2A_C*"/> <bbox w="80.0" h="40.0" x="5957.0" y="183.0"/> <glyph class="state variable" id="_657f3a96-0170-48b4-9ff4-7e1747865a38"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5952.0" y="198.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt1_s107_akt1_akt1_sa90"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: protein phosphatase 2 regulatory subunit B alpha isozyme HUGO:PPP2R2A HGNC:9304 ENTREZ:5520 UNIPROT:P63151 GENECARDS:PPP2R2A REACTOME:49129 KEGG:5520 ATLASONC:GC_PPP2R2A WIKI:PPP2R2A protein phosphatase 2 regulatory subunit B alpha P63151 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18042541 PMID:19556239 PMID:10995457 PMID:16680151 References_end Identifiers_begin: protein phosphatase 2 regulatory subunit B alpha isozyme HUGO:PPP2R2A HGNC:9304 ENTREZ:5520 UNIPROT:P63151 GENECARDS:PPP2R2A REACTOME:49129 KEGG:5520 ATLASONC:GC_PPP2R2A WIKI:PPP2R2A protein phosphatase 2 regulatory subunit B alpha P63151 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18042541 PMID:19556239 PMID:10995457 PMID:16680151 References_end</body> </html> </notes> <label text="PP2A_B55α*"/> <bbox w="80.0" h="40.0" x="5957.0" y="224.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt1_s105_akt1_akt1_sa88"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: protein phosphatase 2 regulatory subunit A alpha HUGO:PPP2R1A HGNC:9302 ENTREZ:5518 UNIPROT:P30153 GENECARDS:PPP2R1A REACTOME:49125 KEGG:5518 ATLASONC:GC_PPP2R1A WIKI:PPP2R1A protein phosphatase 2 regulatory subunit B beta HUGO:PPP2R1B HGNC:9303 ENTREZ:5519 UNIPROT:P30154 GENECARDS:PPP2R1B REACTOME:49127 KEGG:5519 ATLASONC:GC_PPP2R1B WIKI:PPP2R1B PP2A-Aalpha, PR65A, "protein phosphatase 2, 65kDa regulatory subunit A", "protein phosphatase 2A, regulatory subunit A, alpha isoform" protein phosphatase 2, regulatory subunit A, beta Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18559511 PMID:10026142 Structural sub-unit References_end Identifiers_begin: protein phosphatase 2 regulatory subunit A alpha HUGO:PPP2R1A HGNC:9302 ENTREZ:5518 UNIPROT:P30153 GENECARDS:PPP2R1A REACTOME:49125 KEGG:5518 ATLASONC:GC_PPP2R1A WIKI:PPP2R1A protein phosphatase 2 regulatory subunit B beta HUGO:PPP2R1B HGNC:9303 ENTREZ:5519 UNIPROT:P30154 GENECARDS:PPP2R1B REACTOME:49127 KEGG:5519 ATLASONC:GC_PPP2R1B WIKI:PPP2R1B PP2A-Aalpha, PR65A, "protein phosphatase 2, 65kDa regulatory subunit A", "protein phosphatase 2A, regulatory subunit A, alpha isoform" protein phosphatase 2, regulatory subunit A, beta Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18559511 PMID:10026142 Structural sub-unit References_end</body> </html> Identifiers_begin: protein phosphatase 2 regulatory subunit A alpha HUGO:PPP2R1A HGNC:9302 ENTREZ:5518 UNIPROT:P30153 GENECARDS:PPP2R1A REACTOME:49125 KEGG:5518 ATLASONC:GC_PPP2R1A WIKI:PPP2R1A protein phosphatase 2 regulatory subunit B beta HUGO:PPP2R1B HGNC:9303 ENTREZ:5519 UNIPROT:P30154 GENECARDS:PPP2R1B REACTOME:49127 KEGG:5519 ATLASONC:GC_PPP2R1B WIKI:PPP2R1B PP2A-Aalpha, PR65A, "protein phosphatase 2, 65kDa regulatory subunit A", "protein phosphatase 2A, regulatory subunit A, alpha isoform" protein phosphatase 2, regulatory subunit A, beta Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18559511 PMID:10026142 Structural sub-unit References_end</body> </html> </notes> <label text="PP2A_A*"/> <bbox w="80.0" h="40.0" x="5958.0" y="141.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt1_s485_akt1_akt1_sa325" compartmentRef="akt1_akt1_c2_akt1_akt1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re1:(MAP:survival) PMID:10783894 PMID:20673124 PMID:11094066 PMID:11994454 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27 Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="p27KIP1*"/> <bbox w="70.0" h="25.0" x="5003.0" y="1264.5"/> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt1_s625_akt1_akt1_sa426" compartmentRef="akt1_akt1_c2_akt1_akt1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re163:(MAP:survival) PMID:21177869 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PH domain and leucine rich repeat protein phosphatase 1 HUGO:PHLPP1 HGNC:20610 ENTREZ:23239 UNIPROT:O60346 GENECARDS:PHLPP1 REACTOME:199433 KEGG:23239 ATLASONC:PHLPP1ID44544ch18q21 WIKI:PHLPP1 PH domain and leucine rich repeat protein phosphatase 2 HUGO:PHLPP2 HGNC:29149 ENTREZ:23035 UNIPROT:Q6ZVD8 GENECARDS:PHLPP2 REACTOME:242675 KEGG:23035 ATLASONC:PHLPP2ID44546ch16q22 WIKI:PHLPP2 ENTREZ23035 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18511290 References_end</body> </html> </notes> <label text="PHLPP*"/> <bbox w="70.0" h="25.0" x="4922.0" y="1426.5"/> </glyph> <glyph class="phenotype" id="akt1_s_akt1_s415_akt1_akt1_sa269" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re80:(MAP:survival) PMID:18423201 References_end</body> </html> </notes> <label text="mRNA translation"/> <bbox w="80.0" h="30.0" x="4603.0" y="2333.0"/> </glyph> <glyph class="phenotype" id="akt1_s_akt1_s524_akt1_akt1_sa353" compartmentRef="akt1_akt1_c5_akt1_akt1_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re80:(MAP:survival) PMID:16648474 References_end</body> </html> </notes> <label text="Apoptosis"/> <bbox w="80.0" h="30.0" x="6566.0" y="853.0"/> </glyph> <glyph class="phenotype" id="akt1_s_akt1_s566_akt1_akt1_sa372" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <label text="NO production"/> <bbox w="80.0" h="30.0" x="6345.0" y="467.75"/> </glyph> <glyph class="phenotype" id="akt1_s_akt1_s567_akt1_akt1_sa373" compartmentRef="akt1_akt1_c5_akt1_akt1_ca5"> <label text="Prosurvival"/> <bbox w="80.0" h="30.0" x="6438.0" y="710.0"/> </glyph> <glyph class="phenotype" id="akt1_s_akt1_s592_akt1_akt1_sa393" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re136(MAP:survival): PMID:10514377 PMID:17635922 s_akt1_re180:(MAP:survival) PMID:18308511 s_akt1_re181:(MAP:survival) PMID:18298802 s_akt1_re182:(MAP:survival) PMID:18381890 References_end</body> </html> </notes> <label text="Ubiquitination"/> <bbox w="80.0" h="30.0" x="6296.0" y="773.0"/> </glyph> <glyph class="phenotype" id="akt1_s_akt1_s855_akt1_akt1_sa557" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <label text="Autophagy"/> <bbox w="80.0" h="30.0" x="6122.0" y="2408.0"/> </glyph> <glyph class="phenotype" id="akt1_s_akt1_s24_akt1_akt1_sa15" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <label text="RAS activation"/> <bbox w="93.0" h="37.0" x="4407.0" y="178.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s1_akt1_akt1_sa1" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re11(MAP:survival): PMID:15584861 PMID:10648629 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> </notes> <label text="RTK*"/> <clone/> <bbox w="84.0" h="133.0" x="4505.0" y="79.0"/> <glyph class="state variable" id="_167d3d7d-0477-4963-a522-0018351ded35"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4584.0" y="168.0452"/> </glyph> <glyph class="state variable" id="_44bd1015-91e3-4ec3-8d40-c6fd59b54aaa"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4584.0" y="168.0452"/> </glyph> <glyph class="state variable" id="_f40f4332-8bef-4b3c-9a64-282f5c20a506"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4584.0" y="140.5"/> </glyph> <glyph class="unit of information" id="_4c9915fb-5201-44c8-9c03-0530b40664ef"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="4524.5" y="74.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s1_akt1_akt1_sa27" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re11(MAP:survival): PMID:15584861 PMID:10648629 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> </notes> <label text="RTK*"/> <clone/> <bbox w="84.0" h="133.0" x="6305.5454" y="66.454544"/> <glyph class="state variable" id="_9ff7c8ec-fed6-4f65-ac53-80630c703f29"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6384.5454" y="155.49974"/> </glyph> <glyph class="state variable" id="_b9df1122-4244-4fb2-895b-64c534841cc4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6384.5454" y="155.49974"/> </glyph> <glyph class="state variable" id="_c7e0a1c2-7697-488a-85a6-6625b23a1940"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6384.5454" y="127.954544"/> </glyph> <glyph class="unit of information" id="_eee8c257-118a-413a-a5a0-c242e63109d2"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="6325.0454" y="61.454544"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s25_akt1_akt1_sa16" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> </notes> <label text="RAS*"/> <bbox w="80.0" h="40.0" x="4542.9375" y="253.0"/> <glyph class="state variable" id="_ecbd0cf0-2c51-4663-906e-3e497d34407f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4537.9375" y="268.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s38_akt1_akt1_sa237" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: 3-phosphoinositide dependent protein kinase-1 HUGO:PDPK1 HGNC:8816 ENTREZ:5170 UNIPROT:O15530 GENECARDS:PDPK1 REACTOME:61460 KEGG:5170 ATLASONC:GC_PDPK1 WIKI:PDPK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18802401 PMID:17680028 References_end</body> </html> </notes> <label text="PDPK1"/> <bbox w="80.0" h="40.0" x="5223.25" y="1583.0"/> <glyph class="state variable" id="_95555d26-4828-4877-b7d3-7ef553b9addd"> <state value="" variable="S241"/> <bbox w="30.0" h="10.0" x="5248.1543" y="1618.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s40_akt1_akt1_sa398" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: GRB2-associated binding protein 1 HUGO:GAB1 HGNC:4066 ENTREZ:2549 UNIPROT:Q13480 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: GRB2-associated binding protein 1 HUGO:GAB1 HGNC:4066 ENTREZ:2549 UNIPROT:Q13480 GENECARDS:GAB1 REACTOME:147726 ATLASONC:GC_GAB1 WIKI:GAB1 GRB2-associated binding protein 2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11313945 PMID:11940581 References_end</body> </html> </notes> <label text="GAB1"/> <bbox w="80.0" h="40.0" x="6178.5" y="530.0"/> <glyph class="state variable" id="_73ed6126-071d-41ec-a7b6-7e70cef5775d"> <state value="" variable="Y977"/> <bbox w="30.0" h="10.0" x="6163.9927" y="525.0"/> </glyph> <glyph class="state variable" id="_de50b90f-bc32-44e7-a331-e1fa04ed489b"> <state value="" variable="Y989"/> <bbox w="30.0" h="10.0" x="6243.5" y="525.2148"/> </glyph> <glyph class="state variable" id="_85fb6526-5a71-4f3c-998e-5d250d19fb4e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6173.5" y="545.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s56_akt1_akt1_sa277" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re81(MAP:survival): PMID:17444818 ANNOTATION:PTEN is destabilized by phosphorylation on T366 followed by phosphorylation on S370 by GSK3beta. References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end</body> </html> </notes> <label text="PTEN"/> <bbox w="80.0" h="40.0" x="5418.75" y="742.0"/> <glyph class="state variable" id="_2e7e2792-df07-4850-bca3-776625ba2866"> <state value="" variable="S380"/> <bbox w="30.0" h="10.0" x="5453.9976" y="737.0"/> </glyph> <glyph class="state variable" id="_50d25f7f-ad2b-4211-91a5-b22c6d4bc277"> <state value="P" variable="S370"/> <bbox w="35.0" h="10.0" x="5480.8833" y="737.0"/> </glyph> <glyph class="state variable" id="_0f8389df-6647-4b92-b0ed-fc87e57ba8f0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5493.75" y="777.0"/> </glyph> <glyph class="state variable" id="_6a81985b-3c42-4807-b511-58e6fa179576"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5413.75" y="777.0"/> </glyph> <glyph class="state variable" id="_b74ee1ef-3493-40a6-bfcf-f0f6188e7d83"> <state value="" variable="K289"/> <bbox w="30.0" h="10.0" x="5444.4546" y="777.0"/> </glyph> <glyph class="state variable" id="_418915b0-2060-4525-8914-20a1cd7d21ad"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5413.75" y="737.0"/> </glyph> <glyph class="state variable" id="_8e4ef685-2dd7-4632-b7bf-98ae7dc2ebee"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5493.75" y="737.0"/> </glyph> <glyph class="state variable" id="_a3522f3e-f246-4c5a-a8fd-4bf56369c638"> <state value="" variable="K13"/> <bbox w="25.0" h="10.0" x="5406.49" y="777.0"/> </glyph> <glyph class="state variable" id="_e36b6644-3ce5-4cfd-acf8-65bf63b0e766"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="5403.75" y="756.96814"/> </glyph> <glyph class="state variable" id="_239bb665-e921-4c54-a0b7-fefe52f8d4fd"> <state value="" variable="T366"/> <bbox w="30.0" h="10.0" x="5483.75" y="757.0"/> </glyph> <glyph class="state variable" id="_2947ead5-7be4-489a-b6fe-8b4fa590d810"> <state value="" variable="T383"/> <bbox w="30.0" h="10.0" x="5403.75" y="739.4022"/> </glyph> <glyph class="state variable" id="_dad92c35-327f-4d8f-86cb-501e9071c56b"> <state value="" variable="T382"/> <bbox w="30.0" h="10.0" x="5432.282" y="737.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s57_akt1_akt1_sa56" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re12(MAP:survival): PMID:19652529 PMID:19597351 s_akt1_re16(MAP:survival): PMID:17218261 PMID:17218260 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Fyn-related kinase HUGO:FRK HGNC:3955 ENTREZ:2444 UNIPROT:P42685 GENECARDS:FRK KEGG:2444 ATLASONC:GC_FRK WIKI:FRK Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19652529 PMID:19597351 References_end</body> </html> </notes> <label text="FRK"/> <bbox w="80.0" h="40.0" x="5103.25" y="722.0"/> <glyph class="state variable" id="_9fbc0dcc-d40b-4770-b011-d97f7198f7dc"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5095.75" y="737.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s60_akt1_akt1_sa59" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re14(MAP:survival): PMID:17218261 PMID:17218260 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: neural precursor cell expressed developmentally down-regulated 4 HUGO:NEDD4 HGNC:7727 ENTREZ:4734 UNIPROT:P46934 GENECARDS:NEDD4 REACTOME:60051 KEGG:4734 ATLASONC:GC_NEDD4 WIKI:NEDD4 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:BER MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19652529 PMID:17218261 PMID:17218260 PMID:18562292 ANNOTATION:this article describes that NEDD4-1 is not required for PTEN stability and References_end</body> </html> </notes> <label text="NEDD4"/> <bbox w="80.0" h="40.0" x="5130.75" y="658.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s35_akt1_akt1_sa33" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end</body> </html> </notes> <label text="PTEN"/> <clone/> <bbox w="80.0" h="40.0" x="5225.75" y="625.0"/> <glyph class="state variable" id="_0e11d461-67c2-49c7-be44-fc2a43686f22"> <state value="" variable="S380"/> <bbox w="30.0" h="10.0" x="5260.9976" y="620.0"/> </glyph> <glyph class="state variable" id="_f6c7f1fc-4119-4000-9069-bca73fe01b37"> <state value="" variable="S370"/> <bbox w="30.0" h="10.0" x="5290.3833" y="620.0"/> </glyph> <glyph class="state variable" id="_675cfdba-f176-4b83-9a1a-676dfd141b05"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5300.75" y="660.0"/> </glyph> <glyph class="state variable" id="_3b468350-4fc9-454c-9398-dfa1a6e8abae"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5220.75" y="660.0"/> </glyph> <glyph class="state variable" id="_d96863b3-559a-40a9-a27c-a50354e951c5"> <state value="" variable="K289"/> <bbox w="30.0" h="10.0" x="5251.4546" y="660.0"/> </glyph> <glyph class="state variable" id="_4a765f14-a72b-4b15-9de0-02007866184a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5220.75" y="620.0"/> </glyph> <glyph class="state variable" id="_c6bfbb01-7fb8-41dd-9283-cdb59da1cc48"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5300.75" y="620.0"/> </glyph> <glyph class="state variable" id="_e6e1a9b0-8749-428f-bf2e-e687ccf64809"> <state value="" variable="K13"/> <bbox w="25.0" h="10.0" x="5213.49" y="660.0"/> </glyph> <glyph class="state variable" id="_59621ea5-d614-41e0-b52e-52d15d214074"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="5210.75" y="639.96814"/> </glyph> <glyph class="state variable" id="_0f0adeea-7cb0-4fd8-b5c1-c8cbfbdd7f63"> <state value="" variable="T366"/> <bbox w="30.0" h="10.0" x="5290.75" y="640.0"/> </glyph> <glyph class="state variable" id="_9cba1e0a-cf36-4e1b-ae17-939f375fc3ad"> <state value="" variable="T383"/> <bbox w="30.0" h="10.0" x="5210.75" y="622.4022"/> </glyph> <glyph class="state variable" id="_cef9767b-d6c7-49b4-9ad8-ee95505a11a0"> <state value="" variable="T382"/> <bbox w="30.0" h="10.0" x="5239.282" y="620.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s35_akt1_akt1_sa55" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end</body> </html> </notes> <label text="PTEN"/> <clone/> <bbox w="80.0" h="40.0" x="5228.75" y="742.0"/> <glyph class="state variable" id="_512ca1a0-29f8-4acf-9bf0-8f80fbe38710"> <state value="" variable="S380"/> <bbox w="30.0" h="10.0" x="5263.9976" y="737.0"/> </glyph> <glyph class="state variable" id="_9e70c06b-30ac-4cc7-a1dd-f00243b2eb18"> <state value="" variable="S370"/> <bbox w="30.0" h="10.0" x="5293.3833" y="737.0"/> </glyph> <glyph class="state variable" id="_3c6051d2-d9d8-4f82-9322-28c416510f16"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5303.75" y="777.0"/> </glyph> <glyph class="state variable" id="_37129926-5d81-4aa1-84d1-9c86263265b8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5223.75" y="777.0"/> </glyph> <glyph class="state variable" id="_0be686e0-21eb-44d7-9b74-347cf46101d6"> <state value="" variable="K289"/> <bbox w="30.0" h="10.0" x="5254.4546" y="777.0"/> </glyph> <glyph class="state variable" id="_50f31c6f-7e4a-44bc-b17f-fe70d2f11f73"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5223.75" y="737.0"/> </glyph> <glyph class="state variable" id="_904747fd-f5cb-4ba2-ba61-8c865f0f90e3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5303.75" y="737.0"/> </glyph> <glyph class="state variable" id="_4045b762-cf18-4f4c-b397-1faac71a17eb"> <state value="" variable="K13"/> <bbox w="25.0" h="10.0" x="5216.49" y="777.0"/> </glyph> <glyph class="state variable" id="_9123f060-599f-4a4d-973a-f49f077ccfaf"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="5213.75" y="756.96814"/> </glyph> <glyph class="state variable" id="_69d533c3-b6e5-4b5b-9ddb-577498e74cca"> <state value="" variable="T366"/> <bbox w="30.0" h="10.0" x="5293.75" y="757.0"/> </glyph> <glyph class="state variable" id="_a65d566e-3f55-4e9e-ac84-9469ff617204"> <state value="" variable="T383"/> <bbox w="30.0" h="10.0" x="5213.75" y="739.4022"/> </glyph> <glyph class="state variable" id="_7ebd3f24-c563-4a3d-acfd-7d1c70d7bf23"> <state value="" variable="T382"/> <bbox w="30.0" h="10.0" x="5242.282" y="737.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s35_akt1_akt1_sa406" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end</body> </html> </notes> <label text="PTEN"/> <clone/> <bbox w="80.0" h="40.0" x="4809.5" y="1509.0"/> <glyph class="state variable" id="_2ecdf141-ffb3-4823-8748-2cef71719f8f"> <state value="" variable="S380"/> <bbox w="30.0" h="10.0" x="4844.7476" y="1504.0"/> </glyph> <glyph class="state variable" id="_59565c99-8874-4653-8eb4-809fa2e2d3ea"> <state value="" variable="S370"/> <bbox w="30.0" h="10.0" x="4874.1333" y="1504.0"/> </glyph> <glyph class="state variable" id="_fe640d1b-b92b-442b-860b-e3f7e8ff6c13"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4884.5" y="1544.0"/> </glyph> <glyph class="state variable" id="_2aecc728-8a1a-4d63-a6e2-c7a95be7535b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4804.5" y="1544.0"/> </glyph> <glyph class="state variable" id="_08fd9b8b-6a33-4db2-a7f4-9be933d2466b"> <state value="" variable="K289"/> <bbox w="30.0" h="10.0" x="4835.2046" y="1544.0"/> </glyph> <glyph class="state variable" id="_64f9684a-823a-4a5e-abee-d6f0731f29f0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4804.5" y="1504.0"/> </glyph> <glyph class="state variable" id="_66341412-a41f-402b-a43f-d94b1ad6b917"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4884.5" y="1504.0"/> </glyph> <glyph class="state variable" id="_9f46a1cf-850f-4794-be94-d51ee941e94c"> <state value="" variable="K13"/> <bbox w="25.0" h="10.0" x="4797.24" y="1544.0"/> </glyph> <glyph class="state variable" id="_319ef36a-8c8a-4e7f-a333-ff63a8d410c4"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="4794.5" y="1523.9681"/> </glyph> <glyph class="state variable" id="_75115023-e754-428e-9afd-0cf44c2ec2b0"> <state value="" variable="T366"/> <bbox w="30.0" h="10.0" x="4874.5" y="1524.0"/> </glyph> <glyph class="state variable" id="_61695b66-b848-4875-9f43-36f320888b16"> <state value="" variable="T383"/> <bbox w="30.0" h="10.0" x="4794.5" y="1506.4022"/> </glyph> <glyph class="state variable" id="_8f69cb82-471a-4acd-baa5-ddd7b4522100"> <state value="" variable="T382"/> <bbox w="30.0" h="10.0" x="4823.032" y="1504.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s63_akt1_akt1_sa63" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re16(MAP:survival): PMID:17218261 PMID:17218260 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end</body> </html> </notes> <label text="PTEN"/> <bbox w="80.0" h="40.0" x="5215.875" y="901.0"/> <glyph class="state variable" id="_84dfd50b-2f67-4a59-ad5f-3e725aefa729"> <state value="" variable="S380"/> <bbox w="30.0" h="10.0" x="5251.1226" y="896.0"/> </glyph> <glyph class="state variable" id="_93855b7e-cc84-49f8-858f-8726bcde198f"> <state value="" variable="S370"/> <bbox w="30.0" h="10.0" x="5280.5083" y="896.0"/> </glyph> <glyph class="state variable" id="_9eaf67d8-19bf-4fee-9f21-3e35820f63d0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5290.875" y="936.0"/> </glyph> <glyph class="state variable" id="_bb13e5e0-5150-483f-8ca9-d9d81b18d97c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5210.875" y="936.0"/> </glyph> <glyph class="state variable" id="_7c1e43f0-ae28-4426-a48c-430edb9c3bbc"> <state value="Ub" variable="K289"/> <bbox w="40.0" h="10.0" x="5236.5796" y="936.0"/> </glyph> <glyph class="state variable" id="_1106fc4e-5bfc-4ec7-a4a7-f88891f69356"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5210.875" y="896.0"/> </glyph> <glyph class="state variable" id="_2e57a53e-08c3-4a16-9fdf-c1a6f95d2964"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5290.875" y="896.0"/> </glyph> <glyph class="state variable" id="_cb61cd6d-fd0b-4e00-ba26-d05e61ae21a4"> <state value="Ub" variable="K13"/> <bbox w="35.0" h="10.0" x="5198.615" y="936.0"/> </glyph> <glyph class="state variable" id="_373c88d4-173a-44b6-822f-9581b8608e4d"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="5200.875" y="915.96814"/> </glyph> <glyph class="state variable" id="_9b887ce5-2cff-4945-908a-361d63b87bbd"> <state value="" variable="T366"/> <bbox w="30.0" h="10.0" x="5280.875" y="916.0"/> </glyph> <glyph class="state variable" id="_ec083d6e-4abb-4b02-8cc6-6f75048d818e"> <state value="" variable="T383"/> <bbox w="30.0" h="10.0" x="5200.875" y="898.4022"/> </glyph> <glyph class="state variable" id="_7d9a8a9c-67f8-46ad-9f51-ae6877f3166a"> <state value="" variable="T382"/> <bbox w="30.0" h="10.0" x="5229.407" y="896.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s81_akt1_akt1_sa73" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re41(MAP:survival): PMID:19662498 PMID:19387550 PMID:18566586 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Heat shock protein 90 kDa alpha class A member 1 HUGO:HSP90AA1 HGNC:5253 ENTREZ:3320 UNIPROT:P07900 GENECARDS:HSP90AA1 REACTOME:56696 KEGG:3320 ATLASONC:GC_HSP90AA1 WIKI:HSP90AA1 Heat shock protein 90 kDa alpha class A member 2 HUGO:HSP90AA2 HGNC:5256 ENTREZ:3324 UNIPROT:Q14568 GENECARDS:HSP90AA2 ATLASONC:GC_HSP90AA2 WIKI:HSP90AA2 Heat shock protein 90 kDa alpha class B member 1 HUGO:HSP90AB1 HGNC:5258 ENTREZ:3326 UNIPROT:P08238 GENECARDS:HSP90AB1 REACTOME:56698 KEGG:3326 ATLASONC:GC_HSP90AB1 WIKI:HSP90AB1 Heat shock protein 90 kDa beta member 1 HUGO:HSP90B1 HGNC:12028 ENTREZ:7184 UNIPROT:P14625 GENECARDS:HSP90B1 REACTOME:54332 KEGG:7184 ATLASONC:GC_HSP90B1 WIKI:HSP90B1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:HR MAP:dnarepair / MODULE:FANCONI MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19387550 PMID:19662498 PMID:18566586 PMID:10995457 References_end</body> </html> </notes> <label text="HSP90*"/> <bbox w="80.0" h="40.0" x="6095.75" y="497.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s87_akt1_akt1_sa68" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re24:(MAP:survival) PMID:18042541 PMID:18077353 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:cellcycle / MODULE:CYCLIND MAP:cellcycle / MODULE:P21CIP MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:cellcycle / MODULE:CYCLIND MAP:cellcycle / MODULE:P21CIP MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end</body> </html> </notes> <label text="AKT1"/> <bbox w="80.0" h="40.0" x="5964.75" y="489.0"/> <glyph class="state variable" id="_b4cd5230-e6e7-4242-9cb0-6d083f25bf42"> <state value="" variable="T308"/> <bbox w="30.0" h="10.0" x="5949.75" y="487.77402"/> </glyph> <glyph class="state variable" id="_3d5e8474-5992-42bb-ba75-87359f25f3f3"> <state value="P" variable="T450"/> <bbox w="35.0" h="10.0" x="6026.8833" y="484.0"/> </glyph> <glyph class="state variable" id="_ec74af2d-0505-4579-adfb-0f9f09fcfc77"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="6029.75" y="523.1307"/> </glyph> <glyph class="state variable" id="_b97a1cfc-8464-445c-9fdf-882d19eb6506"> <state value="" variable="S129"/> <bbox w="30.0" h="10.0" x="5949.75" y="520.1206"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s91_akt1_akt1_sa77" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re40:(MAP:survival) PMID:19662498 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:cellcycle / MODULE:CYCLIND MAP:cellcycle / MODULE:P21CIP MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:cellcycle / MODULE:CYCLIND MAP:cellcycle / MODULE:P21CIP MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end</body> </html> </notes> <label text="AKT1"/> <bbox w="80.0" h="40.0" x="5964.75" y="557.5"/> <glyph class="state variable" id="_8950db92-8197-4477-8d8f-8159c72fefe5"> <state value="" variable="T308"/> <bbox w="30.0" h="10.0" x="5949.75" y="556.27405"/> </glyph> <glyph class="state variable" id="_eee773cc-e043-4b57-8f46-2b373d398367"> <state value="" variable="T450"/> <bbox w="30.0" h="10.0" x="6029.3833" y="552.5"/> </glyph> <glyph class="state variable" id="_a2238c2e-5fbb-42a5-adfe-5df1401c7ef1"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="6029.75" y="591.6307"/> </glyph> <glyph class="state variable" id="_1478c848-326f-4c05-b25c-c0f25b986a13"> <state value="" variable="S129"/> <bbox w="30.0" h="10.0" x="5949.75" y="588.6206"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s93_akt1_akt1_sa327" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re110:(MAP:survival) PMID:15905173 s_akt1_re113:(MAP:survival) PMID:21474067 s_akt1_re184:(MAP:survival) PMID:18787170 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 GENECARDS:MTOR REACTOME:54978 KEGG:2475 ATLASONC:FRAP1ID40639ch1p36 WIKI:MTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19568798 PMID:17680028 PMID:21157483 References_end</body> </html> </notes> <label text="MTOR"/> <bbox w="80.0" h="40.0" x="5558.125" y="1626.1561"/> <glyph class="state variable" id="_84631267-4a32-4725-8e40-439df1bb512c"> <state value="" variable="S1261"/> <bbox w="35.0" h="10.0" x="5544.1597" y="1621.1561"/> </glyph> <glyph class="state variable" id="_31ae6308-a334-4d29-82b1-7b1e38c39f84"> <state value="" variable="T2446"/> <bbox w="35.0" h="10.0" x="5617.207" y="1621.1561"/> </glyph> <glyph class="state variable" id="_29a5423c-e8c0-4286-a89c-c9a484086428"> <state value="" variable="S2448"/> <bbox w="35.0" h="10.0" x="5620.007" y="1661.1561"/> </glyph> <glyph class="state variable" id="_8976ceb0-a937-445e-8204-37562664e503"> <state value="" variable="S2481"/> <bbox w="35.0" h="10.0" x="5540.625" y="1660.1046"/> </glyph> <glyph class="state variable" id="_0e6cb0a9-41e3-4d81-bb7c-c967c0f9e903"> <state value="" variable="Y631"/> <bbox w="30.0" h="10.0" x="5543.125" y="1641.1561"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s112_akt1_akt1_sa60" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re14(MAP:survival): PMID:17218261 PMID:17218260 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end</body> </html> </notes> <label text="PTEN"/> <bbox w="80.0" h="40.0" x="4990.8125" y="901.0"/> <glyph class="state variable" id="_8c3d8ad1-0da7-4623-8b83-1df807b9d3a5"> <state value="" variable="S380"/> <bbox w="30.0" h="10.0" x="5026.06" y="896.0"/> </glyph> <glyph class="state variable" id="_58de458f-c0cb-41b8-9a1a-228f3ad198ab"> <state value="" variable="S370"/> <bbox w="30.0" h="10.0" x="5055.446" y="896.0"/> </glyph> <glyph class="state variable" id="_971b4d9f-8c31-4eea-a887-55547709480b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5065.8125" y="936.0"/> </glyph> <glyph class="state variable" id="_daa159a1-fa42-45e1-b98b-c57edfabaae4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4985.8125" y="936.0"/> </glyph> <glyph class="state variable" id="_378ae2c9-dc90-4a2c-950d-b917e4a2a574"> <state value="" variable="K289"/> <bbox w="30.0" h="10.0" x="5016.517" y="936.0"/> </glyph> <glyph class="state variable" id="_4cf9d4d7-126a-42cd-88c2-071b4c02ccda"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4985.8125" y="896.0"/> </glyph> <glyph class="state variable" id="_13486526-6fed-4c83-83ca-ea43054f2d4b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5065.8125" y="896.0"/> </glyph> <glyph class="state variable" id="_2376a387-412f-4d25-93cf-f64854278ae4"> <state value="Ub" variable="K13"/> <bbox w="35.0" h="10.0" x="4973.5527" y="936.0"/> </glyph> <glyph class="state variable" id="_eec0a902-b91f-4848-85dd-3cb2a6cc1e74"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="4975.8125" y="915.96814"/> </glyph> <glyph class="state variable" id="_4e3562ba-ed45-4028-ad30-ded2723f921f"> <state value="" variable="T366"/> <bbox w="30.0" h="10.0" x="5055.8125" y="916.0"/> </glyph> <glyph class="state variable" id="_89ca8ebc-490a-49af-8c63-9b8111c233e1"> <state value="" variable="T383"/> <bbox w="30.0" h="10.0" x="4975.8125" y="898.4022"/> </glyph> <glyph class="state variable" id="_cba06dd8-a6ee-436b-9621-dda59f9b80e7"> <state value="" variable="T382"/> <bbox w="30.0" h="10.0" x="5004.3447" y="896.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s114_akt1_akt1_sa62" compartmentRef="akt1_akt1_c2_akt1_akt1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re15(MAP:survival): PMID:17218261 PMID:17218260 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end</body> </html> </notes> <label text="PTEN"/> <bbox w="80.0" h="40.0" x="4910.5" y="1052.0"/> <glyph class="state variable" id="_6e87577d-31ad-4451-bdd0-350016bd8b43"> <state value="" variable="S380"/> <bbox w="30.0" h="10.0" x="4945.7476" y="1047.0"/> </glyph> <glyph class="state variable" id="_1296c4e5-7830-40bf-8bec-4be0e09c8109"> <state value="" variable="S370"/> <bbox w="30.0" h="10.0" x="4975.1333" y="1047.0"/> </glyph> <glyph class="state variable" id="_1a5c2334-421c-48d2-a294-f242f8ca4d01"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4985.5" y="1087.0"/> </glyph> <glyph class="state variable" id="_317408f8-1d08-46da-8ff9-b92d06209f2b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4905.5" y="1087.0"/> </glyph> <glyph class="state variable" id="_c0d0a31d-3d64-4a17-8107-501b4bc86cdd"> <state value="" variable="K289"/> <bbox w="30.0" h="10.0" x="4936.2046" y="1087.0"/> </glyph> <glyph class="state variable" id="_20b552d9-36cd-494f-b8c1-f51a8e860873"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4905.5" y="1047.0"/> </glyph> <glyph class="state variable" id="_31946c77-48ca-4e6b-9286-6b6839ec6e05"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4985.5" y="1047.0"/> </glyph> <glyph class="state variable" id="_22334140-42a3-4c15-a0d7-2f747976a719"> <state value="Ub" variable="K13"/> <bbox w="35.0" h="10.0" x="4893.24" y="1087.0"/> </glyph> <glyph class="state variable" id="_fafa4bcb-3f82-4747-a5a0-d22966c08543"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="4895.5" y="1066.9681"/> </glyph> <glyph class="state variable" id="_6dfb25a7-09e8-441a-89c4-7da6d3ea3162"> <state value="" variable="T366"/> <bbox w="30.0" h="10.0" x="4975.5" y="1067.0"/> </glyph> <glyph class="state variable" id="_297b0476-29d4-432f-a508-ccc4b9e26eda"> <state value="" variable="T383"/> <bbox w="30.0" h="10.0" x="4895.5" y="1049.4022"/> </glyph> <glyph class="state variable" id="_683a2fe8-0f8d-4d2e-b7b2-15eb2c7ec6ae"> <state value="" variable="T382"/> <bbox w="30.0" h="10.0" x="4924.032" y="1047.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s115_akt1_akt1_sa91" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re25(MAP:survival): PMID:17218261 PMID:17218260 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end</body> </html> </notes> <label text="PTEN"/> <bbox w="80.0" h="40.0" x="5096.75" y="901.0"/> <glyph class="state variable" id="_cc1881bc-a3f3-4479-909a-4f41e6c9ddf3"> <state value="" variable="S380"/> <bbox w="30.0" h="10.0" x="5131.9976" y="896.0"/> </glyph> <glyph class="state variable" id="_1f4d961a-cec0-483d-8722-3450a4ddbeec"> <state value="" variable="S370"/> <bbox w="30.0" h="10.0" x="5161.3833" y="896.0"/> </glyph> <glyph class="state variable" id="_5a5ee6bf-22c7-4a05-b657-c7d7399d04c2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5171.75" y="936.0"/> </glyph> <glyph class="state variable" id="_47539ed2-2eeb-4b6f-bf09-1c21d949a753"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5091.75" y="936.0"/> </glyph> <glyph class="state variable" id="_50248e61-0feb-40ea-aa61-b00b9d9deee5"> <state value="Ub" variable="K289"/> <bbox w="40.0" h="10.0" x="5117.4546" y="936.0"/> </glyph> <glyph class="state variable" id="_ca0dd28b-c758-4247-95f9-d97b338e1b15"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5091.75" y="896.0"/> </glyph> <glyph class="state variable" id="_a8e0dcf9-ad5b-4afb-a7d2-0b80de628654"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5171.75" y="896.0"/> </glyph> <glyph class="state variable" id="_aae8ec9a-31a5-4819-ba6e-47af33323ec5"> <state value="" variable="K13"/> <bbox w="25.0" h="10.0" x="5084.49" y="936.0"/> </glyph> <glyph class="state variable" id="_cfa32b50-d037-40f6-8232-832b3702738e"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="5081.75" y="915.96814"/> </glyph> <glyph class="state variable" id="_64809f53-0e0d-4a67-af93-4c1615b7d1f4"> <state value="" variable="T366"/> <bbox w="30.0" h="10.0" x="5161.75" y="916.0"/> </glyph> <glyph class="state variable" id="_2c649555-eb20-46a0-b88d-b5eccae65390"> <state value="" variable="T383"/> <bbox w="30.0" h="10.0" x="5081.75" y="898.4022"/> </glyph> <glyph class="state variable" id="_bfc4e349-39db-47ab-ba59-005f44b1412f"> <state value="" variable="T382"/> <bbox w="30.0" h="10.0" x="5110.282" y="896.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s116_akt1_akt1_sa92" compartmentRef="akt1_akt1_c2_akt1_akt1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re26(MAP:survival): PMID:17218261 PMID:17218260 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end</body> </html> </notes> <label text="PTEN"/> <bbox w="80.0" h="40.0" x="5015.5" y="1051.0"/> <glyph class="state variable" id="_919fc767-e629-4f31-9e57-ee3f1aab3ebb"> <state value="" variable="S380"/> <bbox w="30.0" h="10.0" x="5050.7476" y="1046.0"/> </glyph> <glyph class="state variable" id="_c5c77b4c-e69a-42bd-9083-a57aa8bb0720"> <state value="" variable="S370"/> <bbox w="30.0" h="10.0" x="5080.1333" y="1046.0"/> </glyph> <glyph class="state variable" id="_2b36ce71-2498-49cd-b599-3e5e66b49d53"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5090.5" y="1086.0"/> </glyph> <glyph class="state variable" id="_5e57347f-d9e4-4972-a62c-8db8c663df1f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5010.5" y="1086.0"/> </glyph> <glyph class="state variable" id="_656ec48d-b1db-4b23-8cb6-49d8c64ef7b3"> <state value="Ub" variable="K289"/> <bbox w="40.0" h="10.0" x="5036.2046" y="1086.0"/> </glyph> <glyph class="state variable" id="_505e4667-35de-4cc5-8e23-2aaf898bce2d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5010.5" y="1046.0"/> </glyph> <glyph class="state variable" id="_0c7f094b-c4b0-4f77-85a6-940c8b554b48"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5090.5" y="1046.0"/> </glyph> <glyph class="state variable" id="_bae2f571-6e16-4999-bfa3-9c19c6418224"> <state value="" variable="K13"/> <bbox w="25.0" h="10.0" x="5003.24" y="1086.0"/> </glyph> <glyph class="state variable" id="_0faf0ae7-0836-452f-b3c9-650677653129"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="5000.5" y="1065.9681"/> </glyph> <glyph class="state variable" id="_e5b85ab8-30c8-41ee-9577-676bf3431c32"> <state value="" variable="T366"/> <bbox w="30.0" h="10.0" x="5080.5" y="1066.0"/> </glyph> <glyph class="state variable" id="_0f7bc4ea-9298-45fa-9859-802a22d2eaeb"> <state value="" variable="T383"/> <bbox w="30.0" h="10.0" x="5000.5" y="1048.4022"/> </glyph> <glyph class="state variable" id="_15dd2c28-25df-411f-9ad6-aae878ae0ec8"> <state value="" variable="T382"/> <bbox w="30.0" h="10.0" x="5029.032" y="1046.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s118_akt1_akt1_sa94" compartmentRef="akt1_akt1_c2_akt1_akt1_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end</body> </html> </notes> <label text="PTEN"/> <bbox w="80.0" h="40.0" x="4944.528" y="1193.2222"/> <glyph class="state variable" id="_68428965-77aa-4c51-9dc3-4fe94d9462c5"> <state value="" variable="S380"/> <bbox w="30.0" h="10.0" x="4979.7754" y="1188.2222"/> </glyph> <glyph class="state variable" id="_ef28a172-96c7-41eb-a10a-0f2f121e16ff"> <state value="" variable="S370"/> <bbox w="30.0" h="10.0" x="5009.161" y="1188.2222"/> </glyph> <glyph class="state variable" id="_6dcd69a9-cc87-478f-a5da-ab5a6f4283c8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5019.528" y="1228.2222"/> </glyph> <glyph class="state variable" id="_a44a4a55-1207-4c25-9a5c-cc27073d740a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4939.528" y="1228.2222"/> </glyph> <glyph class="state variable" id="_b4c5966d-a803-4b56-bee7-723cc08ace5e"> <state value="" variable="K289"/> <bbox w="30.0" h="10.0" x="4970.2324" y="1228.2222"/> </glyph> <glyph class="state variable" id="_95b94483-be9e-4bb5-acaf-a3484f9d9550"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4939.528" y="1188.2222"/> </glyph> <glyph class="state variable" id="_11316b19-8d42-4083-a332-f41fbe8ebe17"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5019.528" y="1188.2222"/> </glyph> <glyph class="state variable" id="_083a195f-65bb-41ad-b344-163edd1cd801"> <state value="" variable="K13"/> <bbox w="25.0" h="10.0" x="4932.268" y="1228.2222"/> </glyph> <glyph class="state variable" id="_4ab27f0b-11a3-4859-838d-f8c6d0079603"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="4929.528" y="1208.1903"/> </glyph> <glyph class="state variable" id="_4abea49f-597b-417e-8ca0-ad11cb520bb3"> <state value="" variable="T366"/> <bbox w="30.0" h="10.0" x="5009.528" y="1208.2222"/> </glyph> <glyph class="state variable" id="_a0b442dd-e1d5-49b0-8967-016a2b433165"> <state value="" variable="T383"/> <bbox w="30.0" h="10.0" x="4929.528" y="1190.6244"/> </glyph> <glyph class="state variable" id="_40e18526-6905-460b-a24f-bc159ce6f0b3"> <state value="" variable="T382"/> <bbox w="30.0" h="10.0" x="4958.06" y="1188.2222"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s130_akt1_akt1_sa105" compartmentRef="akt1_akt1_c3_akt1_akt1_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re37(MAP:survival): PMID:16636147 ANNOTATION:THE PHOSPHORYLATION STATE OF TSC2 IS NOT OFF INFLUENCE ON THE GTPase ACTIVITY OF THE PROTEIN References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: RAS homolog enriched in brain HUGO:RHEB HGNC:10011 ENTREZ:6009 UNIPROT:Q15382 GENECARDS:RHEB REACTOME:63056 KEGG:6009 ATLASONC:GC_RHEB WIKI:RHEB Q15382 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19143635 PMID:18466115 References_end</body> </html> </notes> <label text="RHEB"/> <bbox w="80.0" h="40.0" x="6286.0" y="1344.25"/> <glyph class="state variable" id="_75688da5-152d-4e4b-b723-1c5d7eaec6e3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6361.0" y="1339.25"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s131_akt1_akt1_sa106" compartmentRef="akt1_akt1_c3_akt1_akt1_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re37(MAP:survival): PMID:16636147 ANNOTATION:THE PHOSPHORYLATION STATE OF TSC2 IS NOT OFF INFLUENCE ON THE GTPase ACTIVITY OF THE PROTEIN s_akt1_re61:(MAP:survival) PMID:17604271 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: RAS homolog enriched in brain HUGO:RHEB HGNC:10011 ENTREZ:6009 UNIPROT:Q15382 GENECARDS:RHEB REACTOME:63056 KEGG:6009 ATLASONC:GC_RHEB WIKI:RHEB Q15382 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19143635 PMID:18466115 References_end</body> </html> </notes> <label text="RHEB"/> <bbox w="80.0" h="40.0" x="6453.25" y="1344.25"/> <glyph class="state variable" id="_9cb724f2-5248-4a17-aa35-ae5bd3f4a75f"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="6525.75" y="1339.25"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s135_akt1_akt1_sa109" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re40:(MAP:survival) PMID:19662498 s_akt1_re81(MAP:survival): PMID:17444818 ANNOTATION:PTEN is destabilized by phosphorylation on T366 followed by phosphorylation on S370 by GSK3beta. s_akt1_re147(MAP:survival): PMID:11707428 phospho- rylation of the PTEN tail negatively regulates PTEN activity PMID:11035045 phosphorylation of PTEN by CK2 is important for PTEN protein stability to proteasome-mediated degradation References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: casein kinase 2 alpha 1 polypeptide HUGO:CSNK2A1 HGNC:2457 ENTREZ:1457 UNIPROT:P68400 GENECARDS:CSNK2A1 REACTOME:201673 KEGG:1457 ATLASONC:GC_CSNK2A1 WIKI:CSNK2A1 casein kinase 2 alpha prime polypeptide HUGO:CSNK2A2 HGNC:2459 ENTREZ:1459 UNIPROT:P19784 GENECARDS:CSNK2A2 REACTOME:57879 KEGG:1459 ATLASONC:GC_CSNK2A2 WIKI:CSNK2A2 casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:HR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19662498 PMID:17444818 PMID:11035045 References_end</body> </html> </notes> <label text="CK2*"/> <bbox w="80.0" h="40.0" x="5535.0" y="652.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s136_akt1_akt1_sa112" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re40:(MAP:survival) PMID:19662498 s_akt1_re41(MAP:survival): PMID:19662498 PMID:19387550 PMID:18566586 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:cellcycle / MODULE:CYCLIND MAP:cellcycle / MODULE:P21CIP MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:cellcycle / MODULE:CYCLIND MAP:cellcycle / MODULE:P21CIP MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end</body> </html> </notes> <label text="AKT1"/> <bbox w="80.0" h="40.0" x="5963.5" y="627.0"/> <glyph class="state variable" id="_5dc3d84f-1539-4171-8b7a-3e82b99071c2"> <state value="" variable="T308"/> <bbox w="30.0" h="10.0" x="5948.5" y="625.77405"/> </glyph> <glyph class="state variable" id="_be36155c-bac9-428f-aeea-9860303cac0f"> <state value="" variable="T450"/> <bbox w="30.0" h="10.0" x="6028.1333" y="622.0"/> </glyph> <glyph class="state variable" id="_1732fb94-7be7-4071-8358-d37c9093e5e8"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="6028.5" y="661.1307"/> </glyph> <glyph class="state variable" id="_e623130b-64c6-4d1d-afd0-8fbe24a21c07"> <state value="P" variable="S129"/> <bbox w="35.0" h="10.0" x="5946.0" y="658.1206"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s156_akt1_akt1_sa119" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re44:(MAP:survival) PMID:16464865 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: hect (homologous to the E6-AP (UBE3A) carboxyl terminus) domain and RCC1 (CHC1)-like domain (RLD) 1 HUGO:HERC1 HGNC:4867 ENTREZ:8925 UNIPROT:Q15751 GENECARDS:HERC1 KEGG:8925 ATLASONC:GC_HERC1 WIKI:HERC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16464865 PMID:18291711 References_end</body> </html> </notes> <label text="HERC1"/> <bbox w="80.0" h="40.0" x="5758.222" y="1109.5555"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s157_akt1_akt1_sa120" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 GENECARDS:TSC2 REACTOME:404219 KEGG:7249 ATLASONC:TSC2ID184 WIKI:TSC2 P49815 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 GENECARDS:TSC2 REACTOME:404219 KEGG:7249 ATLASONC:TSC2ID184 WIKI:TSC2 P49815 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end</body> </html> </notes> <label text="TSC2"/> <bbox w="80.0" h="40.0" x="5768.0" y="1243.5555"/> <glyph class="state variable" id="_4db89a4a-bef8-4854-a25d-23fa2ceb6ab7"> <state value="" variable="S1086"/> <bbox w="35.0" h="10.0" x="5830.5" y="1260.0219"/> </glyph> <glyph class="state variable" id="_b58ed137-735f-4c25-bd39-d4822c44ace2"> <state value="" variable="S981"/> <bbox w="30.0" h="10.0" x="5829.582" y="1238.5555"/> </glyph> <glyph class="state variable" id="_66f64948-0774-4292-8e68-d23b2f144fb1"> <state value="" variable="S1130"/> <bbox w="35.0" h="10.0" x="5788.4023" y="1278.5555"/> </glyph> <glyph class="state variable" id="_f9cd9998-ddb0-42ee-a1f9-d9d51627a401"> <state value="" variable="T1462"/> <bbox w="35.0" h="10.0" x="5750.9927" y="1238.5555"/> </glyph> <glyph class="state variable" id="_9d6247e2-f1b1-4886-b077-8423cffd2a5e"> <state value="" variable="S1132"/> <bbox w="35.0" h="10.0" x="5750.5" y="1277.504"/> </glyph> <glyph class="state variable" id="_076e2134-c1e0-4cc4-8f35-93464bca8676"> <state value="" variable="S939"/> <bbox w="30.0" h="10.0" x="5791.0303" y="1238.5555"/> </glyph> <glyph class="state variable" id="_1dd6f922-f722-4340-8a59-9008d8a40d5c"> <state value="" variable="S1088"/> <bbox w="35.0" h="10.0" x="5829.882" y="1278.5555"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s159_akt1_akt1_sa121" compartmentRef="akt1_akt1_c3_akt1_akt1_ca3"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: tuberous sclerosis 1 HUGO:TSC1 HGNC:12362 ENTREZ:7248 UNIPROT:Q92574 GENECARDS:TSC1 REACTOME:66499 KEGG:7248 ATLASONC:TSC1ID183 WIKI:TSC1 Q92574 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end Identifiers_begin: tuberous sclerosis 1 HUGO:TSC1 HGNC:12362 ENTREZ:7248 UNIPROT:Q92574 GENECARDS:TSC1 REACTOME:66499 KEGG:7248 ATLASONC:TSC1ID183 WIKI:TSC1 Q92574 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end</body> </html> </notes> <label text="TSC1"/> <clone/> <bbox w="80.0" h="40.0" x="6190.222" y="1282.5354"/> <glyph class="state variable" id="_448c576e-68f3-4b33-ba1b-ee9378c7bde9"> <state value="" variable="T417"/> <bbox w="30.0" h="10.0" x="6175.715" y="1277.5354"/> </glyph> <glyph class="state variable" id="_b3218cba-ed2e-4eea-8b39-549a4a19a784"> <state value="" variable="S487"/> <bbox w="30.0" h="10.0" x="6255.222" y="1277.7501"/> </glyph> <glyph class="state variable" id="_6e07357d-7852-4b7b-99a5-06ac035c0317"> <state value="" variable="S584"/> <bbox w="30.0" h="10.0" x="6252.308" y="1317.5354"/> </glyph> <glyph class="state variable" id="_ab1a2b4f-0502-4b6c-8b2b-ce86e3d064c7"> <state value="" variable="T1047"/> <bbox w="35.0" h="10.0" x="6172.722" y="1317.2577"/> </glyph> <glyph class="state variable" id="_34f3deba-f59e-4aa7-91dc-7c746eb0d57d"> <state value="" variable="S511"/> <bbox w="30.0" h="10.0" x="6255.222" y="1297.5354"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s159_akt1_akt1_sa122" compartmentRef="akt1_akt1_c3_akt1_akt1_ca3"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: tuberous sclerosis 1 HUGO:TSC1 HGNC:12362 ENTREZ:7248 UNIPROT:Q92574 GENECARDS:TSC1 REACTOME:66499 KEGG:7248 ATLASONC:TSC1ID183 WIKI:TSC1 Q92574 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end Identifiers_begin: tuberous sclerosis 1 HUGO:TSC1 HGNC:12362 ENTREZ:7248 UNIPROT:Q92574 GENECARDS:TSC1 REACTOME:66499 KEGG:7248 ATLASONC:TSC1ID183 WIKI:TSC1 Q92574 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end</body> </html> </notes> <label text="TSC1"/> <clone/> <bbox w="80.0" h="40.0" x="6561.222" y="1168.5354"/> <glyph class="state variable" id="_29bff9ed-4381-480d-adcf-30ad8ee6bf9d"> <state value="" variable="T417"/> <bbox w="30.0" h="10.0" x="6546.715" y="1163.5354"/> </glyph> <glyph class="state variable" id="_289ce327-d18f-4c25-a2d1-1cb0ef5ec154"> <state value="" variable="S487"/> <bbox w="30.0" h="10.0" x="6626.222" y="1163.7501"/> </glyph> <glyph class="state variable" id="_8da189e8-40e5-4020-a4f8-850baa4321f2"> <state value="" variable="S584"/> <bbox w="30.0" h="10.0" x="6623.308" y="1203.5354"/> </glyph> <glyph class="state variable" id="_fc118ed9-9111-42b8-bb61-6afc9d83d824"> <state value="" variable="T1047"/> <bbox w="35.0" h="10.0" x="6543.722" y="1203.2577"/> </glyph> <glyph class="state variable" id="_6274988b-336d-49b6-8573-baf1ce9ab619"> <state value="" variable="S511"/> <bbox w="30.0" h="10.0" x="6626.222" y="1183.5354"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s170_akt1_akt1_sa134" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re113:(MAP:survival) PMID:21474067 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: regulatory associated protein of MTOR complex 1 HUGO:RPTOR HGNC:30287 ENTREZ:57521 UNIPROT:Q8N122 GENECARDS:RPTOR REACTOME:153287 KEGG:57521 ATLASONC:GC_RPTOR WIKI:RPTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19864431 PMID:12150925 PMID:15755954 References_end</body> </html> </notes> <label text="RPTOR"/> <bbox w="170.0" h="50.0" x="5602.875" y="1680.53"/> <glyph class="state variable" id="_da6592fe-f507-40da-803f-196117efbb80"> <state value="" variable="S696"/> <bbox w="30.0" h="10.0" x="5587.875" y="1700.4902"/> </glyph> <glyph class="state variable" id="_523beca3-8ce1-42f8-8bd3-82052b3c6bf8"> <state value="" variable="T706"/> <bbox w="30.0" h="10.0" x="5629.783" y="1675.53"/> </glyph> <glyph class="state variable" id="_b1788abe-309b-4c3e-8681-db7166cc4a25"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="5708.892" y="1675.53"/> </glyph> <glyph class="state variable" id="_0d9514a9-04f7-4b6d-90f4-ed9e41d62cb4"> <state value="" variable="S863"/> <bbox w="30.0" h="10.0" x="5708.573" y="1725.53"/> </glyph> <glyph class="state variable" id="_00024fa1-37d5-4bda-807e-4d178393135c"> <state value="" variable="S877"/> <bbox w="30.0" h="10.0" x="5632.6104" y="1725.53"/> </glyph> <glyph class="state variable" id="_e83a094c-9e35-41f2-917f-28d51c3ed4e3"> <state value="" variable="S859"/> <bbox w="30.0" h="10.0" x="5757.875" y="1697.7689"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s171_akt1_akt1_sa135" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re113:(MAP:survival) PMID:21474067 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: MTOR associated protein LST8 homolog (S. cerevisiae) HUGO:MLST8 HGNC:24825 ENTREZ:64223 UNIPROT:Q9BVC4 GENECARDS:MLST8 REACTOME:355793 KEGG:64223 WIKI:MLST8 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:12408816 References_end</body> </html> </notes> <label text="MLST8"/> <bbox w="80.0" h="40.0" x="5525.0625" y="1522.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s177_akt1_akt1_sa140" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re113:(MAP:survival) PMID:21474067 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: AKT1 substrate 1 (proline-rich) HUGO:AKT1S1 HGNC:28426 ENTREZ:84335 UNIPROT:Q96B36 GENECARDS:AKT1S1 REACTOME:200146 KEGG:84335 ATLASONC:GC_AKT1S1 WIKI:AKT1S1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18372248 PMID:17604271 References_end</body> </html> </notes> <label text="PRAS40*"/> <bbox w="80.0" h="40.0" x="5694.0" y="1515.0"/> <glyph class="state variable" id="_7b79fa5b-68e7-4655-94ff-f32ed1de9e68"> <state value="" variable="S183"/> <bbox w="30.0" h="10.0" x="5679.4927" y="1510.0"/> </glyph> <glyph class="state variable" id="_98c75a27-eae0-4562-ad13-9aa9b4725aa7"> <state value="" variable="T246"/> <bbox w="30.0" h="10.0" x="5679.0" y="1546.1206"/> </glyph> <glyph class="state variable" id="_659e5fc8-559a-4490-a0dc-1890b0bb9373"> <state value="" variable="S212"/> <bbox w="30.0" h="10.0" x="5759.0" y="1510.991"/> </glyph> <glyph class="state variable" id="_787e48b5-73cf-4434-80f3-b70bba19a6a7"> <state value="" variable="S221"/> <bbox w="30.0" h="10.0" x="5759.0" y="1549.1306"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s205_akt1_akt1_sa155" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DEP domain containing MTOR-interacting protein HUGO:DEPTOR HGNC:22953 ENTREZ:64798 UNIPROT:Q8TB45 GENECARDS:DEPTOR KEGG:64798 ATLASONC:GC_DEPTOR WIKI:DEPTOR Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19446321 PMID:19706736 References_end</body> </html> </notes> <label text="DEPTOR"/> <clone/> <bbox w="80.0" h="40.0" x="6057.5" y="2292.5"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s205_akt1_akt1_sa156" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DEP domain containing MTOR-interacting protein HUGO:DEPTOR HGNC:22953 ENTREZ:64798 UNIPROT:Q8TB45 GENECARDS:DEPTOR KEGG:64798 ATLASONC:GC_DEPTOR WIKI:DEPTOR Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19446321 PMID:19706736 References_end</body> </html> </notes> <label text="DEPTOR"/> <clone/> <bbox w="80.0" h="40.0" x="5332.5" y="630.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s274_akt1_akt1_sa147" compartmentRef="akt1_akt1_c4_akt1_akt1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re58(MAP:survival): PMID:19446321 ANNOTATION:complex formation with DEPTOR antagonize/inhibits MTOR kinase activity PMID:19706736 s_akt1_re61:(MAP:survival) PMID:17604271 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: AKT1 substrate 1 (proline-rich) HUGO:AKT1S1 HGNC:28426 ENTREZ:84335 UNIPROT:Q96B36 GENECARDS:AKT1S1 REACTOME:200146 KEGG:84335 ATLASONC:GC_AKT1S1 WIKI:AKT1S1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18372248 PMID:17604271 References_end</body> </html> </notes> <label text="PRAS40*"/> <bbox w="80.0" h="40.0" x="6276.0" y="2156.0"/> <glyph class="state variable" id="_873b9bda-2161-489d-8c13-48b187640b01"> <state value="P" variable="S183"/> <bbox w="35.0" h="10.0" x="6258.9927" y="2151.0"/> </glyph> <glyph class="state variable" id="_35325dd7-cea6-4e16-a269-bc43bf898823"> <state value="P" variable="T246"/> <bbox w="35.0" h="10.0" x="6258.5" y="2187.1206"/> </glyph> <glyph class="state variable" id="_e50f563e-86c4-46bd-9f8e-61fe5e86dc45"> <state value="P" variable="S212"/> <bbox w="35.0" h="10.0" x="6338.5" y="2151.991"/> </glyph> <glyph class="state variable" id="_dfb6a71e-ded8-4107-adda-10408979deed"> <state value="P" variable="S221"/> <bbox w="35.0" h="10.0" x="6338.5" y="2190.1306"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s290_akt1_akt1_sa200" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re200:(MAP:survival) PMID:20832730 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <clone/> <bbox w="80.0" h="40.0" x="6152.0" y="2273.5"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s290_akt1_akt1_sa308" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re200:(MAP:survival) PMID:20832730 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <clone/> <bbox w="80.0" h="40.0" x="5287.5" y="968.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s290_akt1_akt1_sa356" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re200:(MAP:survival) PMID:20832730 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <clone/> <bbox w="80.0" h="40.0" x="6373.5" y="631.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s290_akt1_akt1_sa429" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re200:(MAP:survival) PMID:20832730 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <clone/> <bbox w="80.0" h="40.0" x="6721.8823" y="1276.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s290_akt1_akt1_sa439" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re200:(MAP:survival) PMID:20832730 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <clone/> <bbox w="80.0" h="40.0" x="5131.5" y="611.5"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s297_akt1_akt1_sa208" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re68:(MAP:survival) PMID:16286006 s_akt1_re71(MAP:survival): PMID:21233202 PMID:12713446 s_akt1_re73:(MAP:survival) PMID:17053147 s_akt1_re79(MAP:survival): PMID:18423201 PMID:19339977 s_akt1_re86:(MAP:survival) PMID:19720745 s_akt1_re110:(MAP:survival) PMID:15905173 s_akt1_re114:(MAP:survival) PMID:17052453 s_akt1_re198:(MAP:survival) PMID:20832730 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ribosomal protein S6 kinase 70kDa polypeptide 1 "ribosomal protein S6 kinase 70kD polypeptide 1" STK14A HUGO:RPS6KB1 HGNC:10436 ENTREZ:6198 UNIPROT:P23443 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: ribosomal protein S6 kinase 70kDa polypeptide 1 "ribosomal protein S6 kinase 70kD polypeptide 1" STK14A HUGO:RPS6KB1 HGNC:10436 ENTREZ:6198 UNIPROT:P23443 GENECARDS:RPS6KB1 REACTOME:57803 KEGG:6198 ATLASONC:GC_RPS6KB1 WIKI:RPS6KB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16286006 PMID:20647036 PMID:11108711 References_end</body> </html> </notes> <label text="p70α*"/> <bbox w="80.0" h="40.0" x="4901.0" y="1760.0"/> <glyph class="state variable" id="_90cf5789-18f2-4910-876d-d9eb620bb803"> <state value="P" variable="T389"/> <bbox w="35.0" h="10.0" x="4963.5" y="1792.6544"/> </glyph> <glyph class="state variable" id="_6b0fafc0-d02a-4910-ab11-a6d6705531f5"> <state value="P" variable="T229"/> <bbox w="35.0" h="10.0" x="4883.5" y="1757.4022"/> </glyph> <glyph class="state variable" id="_6ffe7193-9475-4e15-a984-92a639289be4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4896.0" y="1775.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s349_akt1_akt1_sa226" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re66:(MAP:survival) PMID:16286006 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ribosomal protein S6 kinase 70kDa polypeptide 1 "ribosomal protein S6 kinase 70kD polypeptide 1" STK14A HUGO:RPS6KB1 HGNC:10436 ENTREZ:6198 UNIPROT:P23443 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: ribosomal protein S6 kinase 70kDa polypeptide 1 "ribosomal protein S6 kinase 70kD polypeptide 1" STK14A HUGO:RPS6KB1 HGNC:10436 ENTREZ:6198 UNIPROT:P23443 GENECARDS:RPS6KB1 REACTOME:57803 KEGG:6198 ATLASONC:GC_RPS6KB1 WIKI:RPS6KB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16286006 PMID:20647036 PMID:11108711 References_end</body> </html> </notes> <label text="p70α*"/> <bbox w="80.0" h="40.0" x="4898.5" y="1577.5"/> <glyph class="state variable" id="_22ee3213-d0e3-45db-bb7e-75a9963b9706"> <state value="P" variable="T389"/> <bbox w="35.0" h="10.0" x="4961.0" y="1610.1544"/> </glyph> <glyph class="state variable" id="_a1549f33-f180-42cc-ad06-52f179034bc5"> <state value="" variable="T229"/> <bbox w="30.0" h="10.0" x="4883.5" y="1574.9022"/> </glyph> <glyph class="state variable" id="_ebf97f73-92c2-44d3-a8c0-20678dd67768"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4893.5" y="1592.5"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s355_akt1_akt1_sa231" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re66:(MAP:survival) PMID:16286006 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: eukaryotic translation initiation factor 4E binding protein 1 HUGO:EIF4EBP1 HGNC:3288 ENTREZ:1978 UNIPROT:Q13541 GENECARDS:EIF4EBP1 REACTOME:84152 KEGG:1978 ATLASONC:EIF4EBP1ID40432ch8p12 WIKI:EIF4EBP1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19339977 PMID:15314020 PMID:12709531 References_end</body> </html> </notes> <label text="4E-BP*"/> <bbox w="80.0" h="40.0" x="4443.5" y="1508.5"/> <glyph class="state variable" id="_43ca2eee-8de9-48d5-a629-1e9d48d32b9f"> <state value="P" variable="T37"/> <bbox w="30.0" h="10.0" x="4428.5" y="1505.9022"/> </glyph> <glyph class="state variable" id="_cb939a0e-b41c-4fdc-a3d8-26a8e5df7700"> <state value="P" variable="T46"/> <bbox w="30.0" h="10.0" x="4508.5" y="1504.491"/> </glyph> <glyph class="state variable" id="_9b0b0e08-d7e0-4355-942d-3e4071df5519"> <state value="P" variable="S65"/> <bbox w="30.0" h="10.0" x="4428.5" y="1540.9851"/> </glyph> <glyph class="state variable" id="_06e44d43-0fc7-437d-bae8-8bdf3eebd43c"> <state value="P" variable="T70"/> <bbox w="30.0" h="10.0" x="4507.882" y="1543.5"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s359_akt1_akt1_sa235" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re67:(MAP:survival) PMID:16286006 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: eukaryotic translation initiation factor 4B HUGO:EIF4B HGNC:3285 ENTREZ:1975 UNIPROT:P23588 GENECARDS:EIF4B REACTOME:72588 KEGG:1975 WIKI:EIF4B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12867079 PMID:19339977 References_end</body> </html> </notes> <label text="EIF4B"/> <bbox w="80.0" h="40.0" x="5064.0" y="1577.0"/> <glyph class="state variable" id="_09c6ecb4-116f-4037-b000-5a5ded69daf3"> <state value="" variable="S422"/> <bbox w="30.0" h="10.0" x="5049.4927" y="1572.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s361_akt1_akt1_sa236" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re67:(MAP:survival) PMID:16286006 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: eukaryotic translation initiation factor 4B HUGO:EIF4B HGNC:3285 ENTREZ:1975 UNIPROT:P23588 GENECARDS:EIF4B REACTOME:72588 KEGG:1975 WIKI:EIF4B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12867079 PMID:19339977 References_end</body> </html> </notes> <label text="EIF4B"/> <bbox w="80.0" h="40.0" x="5065.5" y="1658.0"/> <glyph class="state variable" id="_9012a1d0-2c91-4d80-97b4-656ca145f8c2"> <state value="P" variable="S422"/> <bbox w="35.0" h="10.0" x="5048.4927" y="1653.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s363_akt1_akt1_sa238" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re68:(MAP:survival) PMID:16286006 s_akt1_re85:(MAP:survival) PMID:11500365 s_akt1_re194:(MAP:survival) PMID:20932932 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: 3-phosphoinositide dependent protein kinase-1 HUGO:PDPK1 HGNC:8816 ENTREZ:5170 UNIPROT:O15530 GENECARDS:PDPK1 REACTOME:61460 KEGG:5170 ATLASONC:GC_PDPK1 WIKI:PDPK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18802401 PMID:17680028 References_end</body> </html> </notes> <label text="PDPK1"/> <bbox w="80.0" h="40.0" x="5222.25" y="1658.0"/> <glyph class="state variable" id="_e3efbfe7-c20d-4247-bd65-fc8bde8b507a"> <state value="P" variable="S241"/> <bbox w="35.0" h="10.0" x="5244.6543" y="1693.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s364_akt1_akt1_sa239" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re70:(MAP:survival) PMID:21233202 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ribosomal protein S6 HUGO:RPS6 HGNC:10429 ENTREZ:6194 UNIPROT:P62753 GENECARDS:RPS6 REACTOME:72380 KEGG:6194 ATLASONC:GC_RPS6 WIKI:RPS6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16679021 PMID:21233202 References_end</body> </html> </notes> <label text="RPS6"/> <bbox w="114.0" h="53.0" x="5213.25" y="1727.0"/> <glyph class="state variable" id="_b3f01961-8801-495e-9c64-7978476dc5fd"> <state value="" variable="S235"/> <bbox w="30.0" h="10.0" x="5198.25" y="1773.6068"/> </glyph> <glyph class="state variable" id="_d6cddb08-61ac-467c-8172-e6295052fd5c"> <state value="" variable="S236"/> <bbox w="30.0" h="10.0" x="5198.25" y="1723.2325"/> </glyph> <glyph class="state variable" id="_62ca159c-386e-46be-a656-31a7f2f18209"> <state value="" variable="S240"/> <bbox w="30.0" h="10.0" x="5312.25" y="1723.313"/> </glyph> <glyph class="state variable" id="_065620d2-c95c-4c31-bb6a-5eca5a350481"> <state value="" variable="S244"/> <bbox w="30.0" h="10.0" x="5307.047" y="1775.0"/> </glyph> <glyph class="state variable" id="_162f9bbe-2d50-40ba-965d-c318ba026d00"> <state value="" variable="S247"/> <bbox w="30.0" h="10.0" x="5253.9736" y="1775.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s366_akt1_akt1_sa240" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re70:(MAP:survival) PMID:21233202 s_akt1_re71(MAP:survival): PMID:21233202 PMID:12713446 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ribosomal protein S6 HUGO:RPS6 HGNC:10429 ENTREZ:6194 UNIPROT:P62753 GENECARDS:RPS6 REACTOME:72380 KEGG:6194 ATLASONC:GC_RPS6 WIKI:RPS6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16679021 PMID:21233202 References_end</body> </html> </notes> <label text="RPS6"/> <bbox w="114.0" h="53.0" x="5213.25" y="1826.0"/> <glyph class="state variable" id="_64473b46-8f26-43a4-a7fa-35244b276ee5"> <state value="" variable="S235"/> <bbox w="30.0" h="10.0" x="5198.25" y="1872.6068"/> </glyph> <glyph class="state variable" id="_cfb3902d-7112-45fe-8a66-f46d8d14b4d0"> <state value="" variable="S236"/> <bbox w="30.0" h="10.0" x="5198.25" y="1822.2325"/> </glyph> <glyph class="state variable" id="_2a2f8518-8371-4fff-ba58-6fa39f93a5be"> <state value="" variable="S240"/> <bbox w="30.0" h="10.0" x="5312.25" y="1822.313"/> </glyph> <glyph class="state variable" id="_f48bfb7b-089e-4251-a346-410eb0dd1c6f"> <state value="" variable="S244"/> <bbox w="30.0" h="10.0" x="5307.047" y="1874.0"/> </glyph> <glyph class="state variable" id="_96294b6e-690a-42fc-9436-765b446abbb6"> <state value="P" variable="S247"/> <bbox w="35.0" h="10.0" x="5251.4736" y="1874.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s367_akt1_akt1_sa241" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end</body> </html> Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end</body> </html> Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end</body> </html> </notes> <label text="CK1*"/> <bbox w="80.0" h="40.0" x="5119.0" y="1714.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s372_akt1_akt1_sa242" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re71(MAP:survival): PMID:21233202 PMID:12713446 s_akt1_re77:(MAP:survival) PMID:16286006 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ribosomal protein S6 HUGO:RPS6 HGNC:10429 ENTREZ:6194 UNIPROT:P62753 GENECARDS:RPS6 REACTOME:72380 KEGG:6194 ATLASONC:GC_RPS6 WIKI:RPS6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16679021 PMID:21233202 References_end</body> </html> </notes> <label text="RPS6"/> <bbox w="114.0" h="53.0" x="4900.5" y="1827.0"/> <glyph class="state variable" id="_13e5ac5b-1c4e-438e-8f75-d08c37de2eb1"> <state value="P" variable="S235"/> <bbox w="35.0" h="10.0" x="4883.0" y="1873.6068"/> </glyph> <glyph class="state variable" id="_b159a396-be30-47f5-8307-5a687c2e12e6"> <state value="P" variable="S236"/> <bbox w="35.0" h="10.0" x="4883.0" y="1823.2325"/> </glyph> <glyph class="state variable" id="_7a80566f-3910-4979-ae4a-5321215d76a8"> <state value="P" variable="S240"/> <bbox w="35.0" h="10.0" x="4997.0" y="1823.313"/> </glyph> <glyph class="state variable" id="_0797800e-9de1-42f8-9757-bcec22a785e5"> <state value="P" variable="S244"/> <bbox w="35.0" h="10.0" x="4991.797" y="1875.0"/> </glyph> <glyph class="state variable" id="_56990bb7-c425-40e4-bc14-ba0ac3bb92d4"> <state value="P" variable="S247"/> <bbox w="35.0" h="10.0" x="4938.7236" y="1875.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s379_akt1_akt1_sa246" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re74:(MAP:survival) PMID:17053147 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: programmed cell death 4 (neoplastic transformation inhibitor) HUGO:PDCD4 HGNC:8763 ENTREZ:27250 UNIPROT:Q53EL6 GENECARDS:PDCD4 KEGG:27250 ATLASONC:PDCD4ID41675ch10q24 WIKI:PDCD4 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17053147 PMID:19356152 References_end</body> </html> </notes> <label text="PDCD4"/> <bbox w="80.0" h="40.0" x="5450.0" y="2200.5"/> <glyph class="state variable" id="_74daade9-bbae-4ea6-be38-2e7fefddbcd4"> <state value="P" variable="S67"/> <bbox w="30.0" h="10.0" x="5474.232" y="2195.5"/> </glyph> <glyph class="state variable" id="_ecae7fb3-f059-45ab-8528-8f8844fb3f36"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5445.0" y="2215.4683"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s382_akt1_akt1_sa248" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re74:(MAP:survival) PMID:17053147 s_akt1_re77:(MAP:survival) PMID:16286006 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: eukaryotic translation initiation factor 4A1 HUGO:EIF4A1 HGNC:3282 ENTREZ:1973 UNIPROT:P60842 GENECARDS:EIF4A1 REACTOME:72572 KEGG:1973 ATLASONC:GC_EIF4A1 WIKI:EIF4A1 eukaryotic translation initiation factor 4A2 HUGO:EIF4A2 HGNC:3284 ENTREZ:1974 UNIPROT:Q14240 GENECARDS:EIF4A2 REACTOME:72574 KEGG:1974 ATLASONC:EIF4A2ID262 WIKI:EIF4A2 eukaryotic translation initiation factor 4A3 HUGO:EIF4A3 HGNC:18683 ENTREZ:9775 UNIPROT:P38919 GENECARDS:EIF4A3 REACTOME:57148 KEGG:9775 ATLASONC:GC_EIF4A3 WIKI:EIF4A3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12867079 PMID:19339977 References_end</body> </html> </notes> <label text="EIF4A*"/> <bbox w="80.0" h="40.0" x="5314.125" y="2277.5"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s388_akt1_akt1_sa252" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re75:(MAP:survival) PMID:17053147 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: programmed cell death 4 (neoplastic transformation inhibitor) HUGO:PDCD4 HGNC:8763 ENTREZ:27250 UNIPROT:Q53EL6 GENECARDS:PDCD4 KEGG:27250 ATLASONC:PDCD4ID41675ch10q24 WIKI:PDCD4 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17053147 PMID:19356152 References_end</body> </html> </notes> <label text="PDCD4"/> <bbox w="80.0" h="40.0" x="5450.0" y="2035.0"/> <glyph class="state variable" id="_5af9892f-0dea-4890-bdd8-9d91ed526434"> <state value="P" variable="S67"/> <bbox w="30.0" h="10.0" x="5474.232" y="2030.0"/> </glyph> <glyph class="state variable" id="_781ebf3e-d9d6-42ce-b630-0ac428510d00"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="5440.0" y="2049.9683"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s411_akt1_akt1_sa265" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re77:(MAP:survival) PMID:16286006 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: eukaryotic translation initiation factor 4 gamma 1 HUGO:EIF4G1 HGNC:3296 ENTREZ:1981 UNIPROT:Q04637 GENECARDS:EIF4G1 REACTOME:72583 KEGG:1981 ATLASONC:GC_EIF4G1 WIKI:EIF4G1 eukaryotic translation initiation factor 4 gamma 2 HUGO:EIF4G2 HGNC:3297 ENTREZ:1982 UNIPROT:P78344 GENECARDS:EIF4G2 REACTOME:92738 KEGG:1982 ATLASONC:GC_EIF4G2 WIKI:EIF4G2 eukaryotic translation initiation factor 4 gamma 3 HUGO:EIF4G3 HGNC:3298 ENTREZ:8672 UNIPROT:O43432 GENECARDS:EIF4G3 REACTOME:148636 KEGG:8672 ATLASONC:GC_EIF4G3 WIKI:EIF4G3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12867079 PMID:19339977 References_end</body> </html> </notes> <label text="EIF4G*"/> <bbox w="80.0" h="40.0" x="4854.0" y="1959.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s413_akt1_akt1_sa267" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re77:(MAP:survival) PMID:16286006 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: poly(A) binding protein cytoplasmic 1 HUGO:PABPC1 HGNC:8554 ENTREZ:26986 UNIPROT:P11940 GENECARDS:PABPC1 REACTOME:72228 KEGG:26986 ATLASONC:GC_PABPC1 WIKI:PABPC1 poly(A) binding protein cytoplasmic 3 HUGO:PABPC3 HGNC:8556 ENTREZ:5042 UNIPROT:Q9H361 GENECARDS:PABPC3 KEGG:5042 WIKI:PABPC3 poly(A) binding protein cytoplasmic 5 HUGO:PABP5 GENECARDS:PABP5 WIKI:PABP5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12844354 PMID:15905173 References_end</body> </html> </notes> <label text="PABP1*"/> <bbox w="80.0" h="40.0" x="4443.0" y="1864.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s419_akt1_akt1_sa272" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18423201 s_akt1_re79(MAP:survival): PMID:19339977 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PolymeRASe (DNA-directed) delta interacting protein 3 HUGO:POLDIP3 HGNC:23782 ENTREZ:84271 UNIPROT:Q9BY77 GENECARDS:POLDIP3 KEGG:84271 WIKI:POLDIP3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12522211 References_end</body> </html> </notes> <label text="SKAR*"/> <bbox w="80.0" h="40.0" x="5055.0" y="2400.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s425_akt1_akt1_sa66" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re82(MAP:survival): PMID:17444818 ANNOTATION:PTEN is destabilized by phosphorylation on T366 followed by phosphorylation on S370 by GSK3beta. s_akt1_re12(MAP:survival): PMID:19652529 PMID:19597351 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end</body> </html> </notes> <label text="PTEN"/> <bbox w="80.0" h="40.0" x="5569.75" y="742.0"/> <glyph class="state variable" id="_31184949-50a0-4e6e-a1bc-2b5d7384b1a9"> <state value="" variable="S380"/> <bbox w="30.0" h="10.0" x="5604.9976" y="737.0"/> </glyph> <glyph class="state variable" id="_db611dc0-3353-45bb-a60c-c0d8a42be9a7"> <state value="P" variable="S370"/> <bbox w="35.0" h="10.0" x="5631.8833" y="737.0"/> </glyph> <glyph class="state variable" id="_bdbb1a2d-fbad-4bd4-abb0-13f2e3ec90ae"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5644.75" y="777.0"/> </glyph> <glyph class="state variable" id="_5e092077-8103-4bd1-aa58-c9d2084c5586"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5564.75" y="777.0"/> </glyph> <glyph class="state variable" id="_c5124b06-19ad-40b6-95f6-5080882f2964"> <state value="" variable="K289"/> <bbox w="30.0" h="10.0" x="5595.4546" y="777.0"/> </glyph> <glyph class="state variable" id="_52bb7c20-bb09-4d67-bd0c-6af8c69563ec"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5564.75" y="737.0"/> </glyph> <glyph class="state variable" id="_0dfc92e1-23cc-4983-9d62-d70086869894"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5644.75" y="737.0"/> </glyph> <glyph class="state variable" id="_9be7bc1f-b896-46cc-a9a9-aab55994d76d"> <state value="" variable="K13"/> <bbox w="25.0" h="10.0" x="5557.49" y="777.0"/> </glyph> <glyph class="state variable" id="_140444f6-f40c-499a-af00-a4c426e3a485"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="5554.75" y="756.96814"/> </glyph> <glyph class="state variable" id="_804e4c6f-5f75-47a5-8e67-10a886132b93"> <state value="P" variable="T366"/> <bbox w="35.0" h="10.0" x="5632.25" y="757.0"/> </glyph> <glyph class="state variable" id="_45f38378-8ed3-4a00-b9fc-9a6887a84ffd"> <state value="" variable="T383"/> <bbox w="30.0" h="10.0" x="5554.75" y="739.4022"/> </glyph> <glyph class="state variable" id="_5a876fc6-0655-46b3-a9bb-e80718901cde"> <state value="" variable="T382"/> <bbox w="30.0" h="10.0" x="5583.282" y="737.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s427_akt1_akt1_sa279" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re84(MAP:survival): PMID:20338997 PMID:18570873 PMID:18925875 s_akt1_re196:(MAP:survival) PMID:20832730 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: serum/glucocorticoid regulated kinase 1 HUGO:SGK1 HGNC:10810 ENTREZ:6446 UNIPROT:O00141 GENECARDS:SGK1 REACTOME:64398 KEGG:6446 ATLASONC:GC_SGK1 WIKI:SGK1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19584721 PMID:20338997 PMID:18570873 PMID:18925875 References_end</body> </html> </notes> <label text="SGK1"/> <bbox w="80.0" h="40.0" x="4616.75" y="902.0"/> <glyph class="state variable" id="_09b6cf20-a00c-4e22-8e27-1ce2276c37ad"> <state value="" variable="T256"/> <bbox w="30.0" h="10.0" x="4605.2847" y="897.0"/> </glyph> <glyph class="state variable" id="_733eeff9-91a0-4468-a5f6-19c1a2943db8"> <state value="" variable="S442"/> <bbox w="30.0" h="10.0" x="4681.75" y="933.2789"/> </glyph> <glyph class="state variable" id="_b44a9393-70bf-429b-ab60-7f05e0d9bc38"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4611.75" y="937.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s428_akt1_akt1_sa278" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re84(MAP:survival): PMID:20338997 PMID:18570873 PMID:18925875 s_akt1_re85:(MAP:survival) PMID:11500365 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: serum/glucocorticoid regulated kinase 1 HUGO:SGK1 HGNC:10810 ENTREZ:6446 UNIPROT:O00141 GENECARDS:SGK1 REACTOME:64398 KEGG:6446 ATLASONC:GC_SGK1 WIKI:SGK1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19584721 PMID:20338997 PMID:18570873 PMID:18925875 References_end</body> </html> </notes> <label text="SGK1"/> <bbox w="80.0" h="40.0" x="4738.875" y="902.0"/> <glyph class="state variable" id="_a0896b0c-25cc-462f-b625-dfc2f86663c0"> <state value="" variable="T256"/> <bbox w="30.0" h="10.0" x="4727.4097" y="897.0"/> </glyph> <glyph class="state variable" id="_9edc643b-ce44-4e9a-86ed-6b8824ee681e"> <state value="P" variable="S442"/> <bbox w="35.0" h="10.0" x="4801.375" y="933.2789"/> </glyph> <glyph class="state variable" id="_aa0344ed-fc8c-4a29-b95b-7a2fab976e55"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4733.875" y="937.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s429_akt1_akt1_sa280" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re85:(MAP:survival) PMID:11500365 s_akt1_re96(MAP:survival): PMID:18570873 PMID:18636226 p27 is phosphorylated by Akt RSK1 and RSK2 in early G1 phase s_akt1_re102:(MAP:survival) PMID:11154281 s_akt1_re198:(MAP:survival) PMID:20832730 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: serum/glucocorticoid regulated kinase 1 HUGO:SGK1 HGNC:10810 ENTREZ:6446 UNIPROT:O00141 GENECARDS:SGK1 REACTOME:64398 KEGG:6446 ATLASONC:GC_SGK1 WIKI:SGK1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19584721 PMID:20338997 PMID:18570873 PMID:18925875 References_end</body> </html> </notes> <label text="SGK1"/> <bbox w="80.0" h="40.0" x="4873.875" y="902.0"/> <glyph class="state variable" id="_860ee5d7-6b76-46f8-ba8a-95aea98a4e74"> <state value="P" variable="T256"/> <bbox w="35.0" h="10.0" x="4859.9097" y="897.0"/> </glyph> <glyph class="state variable" id="_a9971614-8e01-40a3-990e-032c2989be65"> <state value="P" variable="S442"/> <bbox w="35.0" h="10.0" x="4936.375" y="933.2789"/> </glyph> <glyph class="state variable" id="_5cca25c6-4539-41cc-aa06-6e3fe8a15bc4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4868.875" y="937.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s448_akt1_akt1_sa297" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27 Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="p27KIP1*"/> <bbox w="80.0" h="40.0" x="5520.5" y="1257.0"/> <glyph class="state variable" id="_0a9e4d52-1bb4-442f-9f83-0f9d14d6d1af"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5555.5" y="1252.0"/> </glyph> <glyph class="state variable" id="_87545e7d-93ed-4694-955d-451e26a900bd"> <state value="" variable="S157"/> <bbox w="30.0" h="10.0" x="5585.5" y="1252.0"/> </glyph> <glyph class="state variable" id="_f353911b-bf09-4835-a36f-2267a2072696"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5555.5" y="1292.0"/> </glyph> <glyph class="state variable" id="_f1cd1e15-3ae6-4a7d-a518-2bfaf5abdb9b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5538.9316" y="1252.0"/> </glyph> <glyph class="state variable" id="_42da3773-eff8-4afe-aa2d-d271df11f25b"> <state value="" variable="S10"/> <bbox w="25.0" h="10.0" x="5508.0" y="1254.4022"/> </glyph> <glyph class="state variable" id="_d0adde1d-8944-4509-9a53-79e67c8dedf2"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="5584.882" y="1292.0"/> </glyph> <glyph class="state variable" id="_171c6ec1-c4b5-4c8b-9acc-cb9666f3db9d"> <state value="" variable="T157"/> <bbox w="30.0" h="10.0" x="5582.082" y="1252.0"/> </glyph> <glyph class="state variable" id="_91fa01e8-b2ab-4be3-9114-7d1699f440ec"> <state value="" variable="T198"/> <bbox w="30.0" h="10.0" x="5505.5" y="1291.7223"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s456_akt1_akt1_sa302" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re96(MAP:survival): PMID:18570873 PMID:18636226 p27 is phosphorylated by Akt RSK1 and RSK2 in early G1 phase References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27 Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="p27KIP1*"/> <bbox w="80.0" h="40.0" x="5559.5" y="872.0"/> <glyph class="state variable" id="_656cb7ff-394a-44fe-945b-b944edeed842"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5594.5" y="867.0"/> </glyph> <glyph class="state variable" id="_68954f1f-b19f-4de4-9cb8-d2e21224272e"> <state value="" variable="S157"/> <bbox w="30.0" h="10.0" x="5624.5" y="867.0"/> </glyph> <glyph class="state variable" id="_dfd983f1-2bd5-478d-a40a-c92f183d7480"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5594.5" y="907.0"/> </glyph> <glyph class="state variable" id="_417a237a-e1e0-403b-8f47-f196a34ddef7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5577.9316" y="867.0"/> </glyph> <glyph class="state variable" id="_36b4dea6-d21f-4dfe-bd1d-ab7f5f815f8c"> <state value="P" variable="S10"/> <bbox w="30.0" h="10.0" x="5544.5" y="869.4022"/> </glyph> <glyph class="state variable" id="_ace68d22-9be2-4009-aa9b-92385ef3c99f"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="5623.882" y="907.0"/> </glyph> <glyph class="state variable" id="_425b16a1-f4bd-4b28-ba26-293d36763b0d"> <state value="" variable="T157"/> <bbox w="30.0" h="10.0" x="5621.082" y="867.0"/> </glyph> <glyph class="state variable" id="_270936b9-d971-4402-b92c-8dbb320d9e86"> <state value="" variable="T198"/> <bbox w="30.0" h="10.0" x="5544.5" y="906.7223"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s459_akt1_akt1_sa306" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re96(MAP:survival): PMID:18570873 PMID:18636226 p27 is phosphorylated by Akt RSK1 and RSK2 in early G1 phase References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ribosomal protein S6 kinase 90kDa polypeptide 1 HUGO:RPS6KA1 HGNC:10430 ENTREZ:6195 UNIPROT:Q15418 GENECARDS:RPS6KA1 REACTOME:57795 KEGG:6195 ATLASONC:RPS6KA1ID43477ch1p36 WIKI:RPS6KA1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16286006 PMID:21233202 References_end</body> </html> </notes> <label text="RSK1*"/> <bbox w="80.0" h="40.0" x="5780.0" y="978.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s460_akt1_akt1_sa307" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re96(MAP:survival): PMID:18570873 PMID:18636226 p27 is phosphorylated by Akt RSK1 and RSK2 in early G1 phase References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ribosomal protein S6 kinase 90kDa polypeptide 2 HUGO:RPS6KA2 HGNC:10431 ENTREZ:6196 UNIPROT:Q15349 GENECARDS:RPS6KA2 REACTOME:57797 KEGG:6196 ATLASONC:GC_RPS6KA2 WIKI:RPS6KA2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16286006 PMID:21233202 References_end</body> </html> </notes> <label text="RSK2*"/> <bbox w="80.0" h="40.0" x="5430.0" y="978.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s465_akt1_akt1_sa311" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re98:(MAP:survival) PMID:19887899 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase 4 HUGO:CDK4 HGNC:1773 ENTREZ:1019 UNIPROT:P11802 GENECARDS:CDK4 REACTOME:68329 KEGG:1019 ATLASONC:CDK4ID238ch12q14 WIKI:CDK4 cyclin-dependent kinase 6 HUGO:CDK6 HGNC:1777 ENTREZ:1021 UNIPROT:Q00534 GENECARDS:CDK6 REACTOME:68335 KEGG:1021 ATLASONC:GC_CDK6 WIKI:CDK6 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 References_end</body> </html> </notes> <label text="CDK4_6*"/> <bbox w="80.0" h="40.0" x="5652.0" y="1037.4021"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s466_akt1_akt1_sa312" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re98:(MAP:survival) PMID:19887899 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 References_end</body> </html> </notes> <label text="CyclinD*"/> <bbox w="80.0" h="40.0" x="5744.0" y="1037.4021"/> <glyph class="state variable" id="_d49ffd0f-cf3b-421b-8eaf-cd852fc46375"> <state value="" variable="T286"/> <bbox w="30.0" h="10.0" x="5809.0" y="1032.6168"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s471_akt1_akt1_sa316" compartmentRef="akt1_akt1_c2_akt1_akt1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re101:(MAP:survival) PMID:11154281 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 GENECARDS:FOXO3 REACTOME:199273 KEGG:2309 ATLASONC:AF6q21ID125 WIKI:FOXO3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16288288 PMID:17646672 References_end</body> </html> </notes> <label text="FOXO3"/> <bbox w="80.0" h="40.0" x="5060.0" y="1199.0"/> <glyph class="state variable" id="_c22d5368-b931-4b2a-bb97-6e03923926ec"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5095.0" y="1194.0"/> </glyph> <glyph class="state variable" id="_b5d030f6-ddba-4515-8bef-c92dbf37d19d"> <state value="" variable="S644"/> <bbox w="30.0" h="10.0" x="5045.0" y="1233.7223"/> </glyph> <glyph class="state variable" id="_da4c8995-24e7-4de5-a1ee-0195d51e2cca"> <state value="" variable="T32"/> <bbox w="25.0" h="10.0" x="5047.5" y="1194.9303"/> </glyph> <glyph class="state variable" id="_891e9f18-c115-49c2-9afd-7f8716a86d71"> <state value="" variable="S253"/> <bbox w="30.0" h="10.0" x="5125.0" y="1233.1306"/> </glyph> <glyph class="state variable" id="_374bb02b-0c2f-41a4-9a88-3edb2f4c9779"> <state value="" variable="S315"/> <bbox w="30.0" h="10.0" x="5121.582" y="1194.0"/> </glyph> <glyph class="state variable" id="_31df3549-ddd9-49bb-9b67-71424d0822bc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5055.0" y="1214.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s473_akt1_akt1_sa317" compartmentRef="akt1_akt1_c2_akt1_akt1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re101:(MAP:survival) PMID:11154281 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 GENECARDS:FOXO3 REACTOME:199273 KEGG:2309 ATLASONC:AF6q21ID125 WIKI:FOXO3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16288288 PMID:17646672 References_end</body> </html> </notes> <label text="FOXO3"/> <bbox w="80.0" h="40.0" x="5060.0" y="1121.0"/> <glyph class="state variable" id="_cad2cd76-af35-4ebc-95fd-8b72cdc596f4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5095.0" y="1116.0"/> </glyph> <glyph class="state variable" id="_c3634a04-a6a0-4e41-a54c-40f470e21e0b"> <state value="" variable="S644"/> <bbox w="30.0" h="10.0" x="5045.0" y="1155.7223"/> </glyph> <glyph class="state variable" id="_22b92bce-fc60-4ac3-882c-ade7890d1778"> <state value="" variable="T32"/> <bbox w="25.0" h="10.0" x="5047.5" y="1116.9303"/> </glyph> <glyph class="state variable" id="_0c07a413-1591-42ea-a9f6-86e923a21a2e"> <state value="" variable="S253"/> <bbox w="30.0" h="10.0" x="5125.0" y="1155.1306"/> </glyph> <glyph class="state variable" id="_3d195ae0-7bd5-491e-be88-6a9280c459e4"> <state value="P" variable="S315"/> <bbox w="35.0" h="10.0" x="5119.082" y="1116.0"/> </glyph> <glyph class="state variable" id="_8a503da6-ed7c-46d6-982a-470cd2a909a9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5055.0" y="1136.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s474_akt1_akt1_sa318" compartmentRef="akt1_akt1_c2_akt1_akt1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re102:(MAP:survival) PMID:11154281 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: serum/glucocorticoid regulated kinase 1 HUGO:SGK1 HGNC:10810 ENTREZ:6446 UNIPROT:O00141 GENECARDS:SGK1 REACTOME:64398 KEGG:6446 ATLASONC:GC_SGK1 WIKI:SGK1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19584721 PMID:20338997 PMID:18570873 PMID:18925875 References_end</body> </html> </notes> <label text="SGK1"/> <bbox w="80.0" h="40.0" x="5178.75" y="1192.0"/> <glyph class="state variable" id="_e0950dda-93fb-48d1-814e-801b10a422f7"> <state value="P" variable="T256"/> <bbox w="35.0" h="10.0" x="5164.7847" y="1187.0"/> </glyph> <glyph class="state variable" id="_0789d073-3888-4137-9b8b-269c8a562086"> <state value="P" variable="S442"/> <bbox w="35.0" h="10.0" x="5241.25" y="1223.2789"/> </glyph> <glyph class="state variable" id="_927d140f-504a-4e48-b2d7-e4eaecb15d33"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5173.75" y="1227.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s477_akt1_akt1_sa319" compartmentRef="akt1_akt1_c2_akt1_akt1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re103:(MAP:survival) PMID:11154281 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 GENECARDS:FOXO3 REACTOME:199273 KEGG:2309 ATLASONC:AF6q21ID125 WIKI:FOXO3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16288288 PMID:17646672 References_end</body> </html> </notes> <label text="FOXO3"/> <bbox w="80.0" h="40.0" x="5112.0" y="1054.0"/> <glyph class="state variable" id="_d4397061-ac25-468b-8365-48e28e887cd9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5147.0" y="1049.0"/> </glyph> <glyph class="state variable" id="_584b0290-447a-4f2c-9050-8ed8116fc773"> <state value="" variable="S644"/> <bbox w="30.0" h="10.0" x="5097.0" y="1088.7223"/> </glyph> <glyph class="state variable" id="_a1d9d08e-9beb-4796-aed7-52aba6108703"> <state value="P" variable="T32"/> <bbox w="30.0" h="10.0" x="5097.0" y="1049.9303"/> </glyph> <glyph class="state variable" id="_7b1accc7-ab0d-4870-8c8b-c37f06b8cb83"> <state value="P" variable="S253"/> <bbox w="35.0" h="10.0" x="5174.5" y="1088.1306"/> </glyph> <glyph class="state variable" id="_b2cd2a91-c243-4cec-89b4-92f5a02ea2ba"> <state value="P" variable="S315"/> <bbox w="35.0" h="10.0" x="5171.082" y="1049.0"/> </glyph> <glyph class="state variable" id="_67b9f8bb-6410-4ce7-b737-9f8cae95ce06"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5107.0" y="1069.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s478_akt1_akt1_sa320" compartmentRef="akt1_akt1_c2_akt1_akt1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re103:(MAP:survival) PMID:11154281 s_akt1_re119(MAP:survival): PMID:15169778 PMID:11923280 PMID:11715018 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:cellcycle / MODULE:CYCLIND MAP:cellcycle / MODULE:P21CIP MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:cellcycle / MODULE:CYCLIND MAP:cellcycle / MODULE:P21CIP MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end</body> </html> </notes> <label text="AKT1"/> <bbox w="80.0" h="40.0" x="5352.5" y="1088.0"/> <glyph class="state variable" id="_218b7fb2-9c60-4a33-be2d-ed57916e0435"> <state value="P" variable="T308"/> <bbox w="35.0" h="10.0" x="5335.0" y="1086.774"/> </glyph> <glyph class="state variable" id="_f11c1eeb-2ea4-46bb-9e5d-8e8e97e7bcca"> <state value="P" variable="T450"/> <bbox w="35.0" h="10.0" x="5414.6333" y="1083.0"/> </glyph> <glyph class="state variable" id="_1f59e8a0-4e36-41ed-939f-c65a877a7f17"> <state value="P" variable="S473"/> <bbox w="35.0" h="10.0" x="5415.0" y="1122.1306"/> </glyph> <glyph class="state variable" id="_15989e57-fb54-48e9-a918-ff884db3c111"> <state value="" variable="S129"/> <bbox w="30.0" h="10.0" x="5337.5" y="1119.1206"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s494_akt1_akt1_sa133" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re110:(MAP:survival) PMID:15905173 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 GENECARDS:MTOR REACTOME:54978 KEGG:2475 ATLASONC:FRAP1ID40639ch1p36 WIKI:MTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19568798 PMID:17680028 PMID:21157483 References_end</body> </html> </notes> <label text="MTOR"/> <bbox w="80.0" h="40.0" x="5682.9375" y="1755.0"/> <glyph class="state variable" id="_ea119254-de95-4fc9-84b2-1a614bf22b1e"> <state value="" variable="S1261"/> <bbox w="35.0" h="10.0" x="5668.972" y="1750.0"/> </glyph> <glyph class="state variable" id="_3b7d51f1-4acd-44d0-8f97-0d40ade3bbd5"> <state value="" variable="T2446"/> <bbox w="35.0" h="10.0" x="5742.0195" y="1750.0"/> </glyph> <glyph class="state variable" id="_b3a97d9b-e754-4aa8-a68c-e9514e9dc307"> <state value="P" variable="S2448"/> <bbox w="40.0" h="10.0" x="5742.3193" y="1790.0"/> </glyph> <glyph class="state variable" id="_46f996ba-bd80-47e3-913e-ddf2856d5e45"> <state value="" variable="S2481"/> <bbox w="35.0" h="10.0" x="5665.4375" y="1788.9485"/> </glyph> <glyph class="state variable" id="_92b9e2c1-498d-455f-adbf-11ba9bca35c8"> <state value="" variable="Y631"/> <bbox w="30.0" h="10.0" x="5667.9375" y="1770.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s499_akt1_akt1_sa336" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end</body> </html> Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end</body> </html> Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end</body> </html> </notes> <label text="GSK3β*"/> <bbox w="80.0" h="40.0" x="5974.0" y="361.0"/> <glyph class="state variable" id="_07660b0b-1090-420c-a952-92ddb2b35441"> <state value="" variable="S9"/> <bbox w="20.0" h="10.0" x="5964.4927" y="356.0"/> </glyph> <glyph class="state variable" id="_73aee217-4060-42d3-a2c4-4c633c945008"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5969.0" y="376.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s501_akt1_akt1_sa337" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end</body> </html> Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end</body> </html> Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end</body> </html> </notes> <label text="GSK3β*"/> <bbox w="80.0" h="40.0" x="6087.5" y="361.0"/> <glyph class="state variable" id="_bfdf7871-d007-4b1c-93d7-ec559202d1f8"> <state value="P" variable="S9"/> <bbox w="25.0" h="10.0" x="6075.4927" y="356.0"/> </glyph> <glyph class="state variable" id="_8c915df3-0db2-498f-a05e-ffeccfe60b0a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6082.5" y="376.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s503_akt1_akt1_sa339" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re115(MAP:survival): PMID:12791379 PMID:10582334 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: inositol polyphosphate-5-phosphatase 145kDa HUGO:INPP5D HGNC:6079 ENTREZ:3635 UNIPROT:Q92835 GENECARDS:INPP5D REACTOME:248250 KEGG:3635 ATLASONC:GC_INPP5D WIKI:INPP5D Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12791379 PMID:10582334 References_end</body> </html> </notes> <label text="SHIP2*"/> <bbox w="80.0" h="40.0" x="5762.0" y="654.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s504_akt1_akt1_sa340" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re116:(MAP:survival) PMID:15808505 s_akt1_re159:(MAP:survival) PMID:19797085 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PH domain and leucine rich repeat protein phosphatase 1 HUGO:PHLPP1 HGNC:20610 ENTREZ:23239 UNIPROT:O60346 GENECARDS:PHLPP1 REACTOME:199433 KEGG:23239 ATLASONC:PHLPP1ID44544ch18q21 WIKI:PHLPP1 O60346 PH domain and leucine rich repeat protein phosphatase 2 HUGO:PHLPP2 HGNC:29149 ENTREZ:23035 UNIPROT:Q6ZVD8 GENECARDS:PHLPP2 REACTOME:242675 KEGG:23035 ATLASONC:PHLPP2ID44546ch16q22 WIKI:PHLPP2 Q6ZVD8 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15808505 PMID:19797085 PMID:18511290 References_end</body> </html> </notes> <label text="PHLPP*"/> <bbox w="80.0" h="40.0" x="5683.0" y="734.0"/> <glyph class="state variable" id="_b1e4cd91-41a6-41bf-86a4-93220c05d3ef"> <state value="" variable="S869"/> <bbox w="30.0" h="10.0" x="5748.0" y="729.2148"/> </glyph> <glyph class="state variable" id="_f63ef2d5-ab95-4ee4-89bc-ea664e3141d8"> <state value="" variable="S847"/> <bbox w="30.0" h="10.0" x="5668.4927" y="729.0"/> </glyph> <glyph class="state variable" id="_69905ad2-5a1c-4ae2-bcd9-949892fd31e2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5678.0" y="749.0"/> </glyph> <glyph class="state variable" id="_6fc28a4d-3fa0-4529-8cd7-2c6b3e9f8979"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5758.0" y="740.7157"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s515_akt1_akt1_sa348" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re118(MAP:survival): PMID:15169778 PMID:11923280 PMID:11715018 PMID:16697215 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 References_end Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 GENECARDS:MDM2 REACTOME:95018 KEGG:4193 ATLASONC:MDM2ID115ch12q15 WIKI:MDM2 Mdm2 p53 binding protein homolog (mouse) Mdm2 p53 binding protein homo Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:CYCLINB MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 PMID:20679392 PMID:15169778 PMID:11923280 PMID:11715018 References_end Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 GENECARDS:MDM2 REACTOME:95018 KEGG:4193 ATLASONC:MDM2ID115ch12q15 WIKI:MDM2 Mdm2 p53 binding protein homolog (mouse) Mdm2 p53 binding protein homo Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:CYCLINB MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 PMID:20679392 PMID:15169778 PMID:11923280 PMID:11715018 References_end</body> </html> </notes> <label text="MDM2"/> <bbox w="80.0" h="40.0" x="4853.0" y="965.0"/> <glyph class="state variable" id="_b10f4b4a-5b70-4afc-865d-dd7c3480f48b"> <state value="P" variable="S166"/> <bbox w="35.0" h="10.0" x="4835.5" y="960.93024"/> </glyph> <glyph class="state variable" id="_cb975b93-4e35-489e-9c90-cbda99fbccfe"> <state value="P" variable="S186"/> <bbox w="35.0" h="10.0" x="4915.5" y="960.99097"/> </glyph> <glyph class="state variable" id="_d0f51e5d-0cff-4f9f-9572-4f8e420c83cc"> <state value="" variable="S188"/> <bbox w="30.0" h="10.0" x="4917.382" y="1000.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s516_akt1_akt1_sa347" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re118(MAP:survival): PMID:15169778 PMID:11923280 PMID:11715018 PMID:16697215 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 References_end Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 GENECARDS:MDM2 REACTOME:95018 KEGG:4193 ATLASONC:MDM2ID115ch12q15 WIKI:MDM2 Mdm2 p53 binding protein homolog (mouse) Mdm2 p53 binding protein homo Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:CYCLINB MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 PMID:20679392 PMID:15169778 PMID:11923280 PMID:11715018 References_end Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 GENECARDS:MDM2 REACTOME:95018 KEGG:4193 ATLASONC:MDM2ID115ch12q15 WIKI:MDM2 Mdm2 p53 binding protein homolog (mouse) Mdm2 p53 binding protein homo Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:CYCLINB MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 PMID:20679392 PMID:15169778 PMID:11923280 PMID:11715018 References_end</body> </html> </notes> <label text="MDM2"/> <bbox w="80.0" h="40.0" x="4990.0" y="965.0"/> <glyph class="state variable" id="_3f256dc6-cc55-4241-8e33-768864791b24"> <state value="" variable="S166"/> <bbox w="30.0" h="10.0" x="4975.0" y="960.93024"/> </glyph> <glyph class="state variable" id="_b7f568f2-d296-467d-8a29-d4e0da30b6e5"> <state value="" variable="S186"/> <bbox w="30.0" h="10.0" x="5055.0" y="960.99097"/> </glyph> <glyph class="state variable" id="_82a622a8-915c-4f54-9ec3-6dd94dfefed1"> <state value="" variable="S188"/> <bbox w="30.0" h="10.0" x="5054.382" y="1000.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s517_akt1_akt1_sa349" compartmentRef="akt1_akt1_c2_akt1_akt1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re120(MAP:survival): PMID:15169778 PMID:11923280 PMID:11715018 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 References_end Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 GENECARDS:MDM2 REACTOME:95018 KEGG:4193 ATLASONC:MDM2ID115ch12q15 WIKI:MDM2 Mdm2 p53 binding protein homolog (mouse) Mdm2 p53 binding protein homo Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:CYCLINB MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 PMID:20679392 PMID:15169778 PMID:11923280 PMID:11715018 References_end Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 GENECARDS:MDM2 REACTOME:95018 KEGG:4193 ATLASONC:MDM2ID115ch12q15 WIKI:MDM2 Mdm2 p53 binding protein homolog (mouse) Mdm2 p53 binding protein homo Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:CYCLINB MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 PMID:20679392 PMID:15169778 PMID:11923280 PMID:11715018 References_end</body> </html> </notes> <label text="MDM2"/> <bbox w="80.0" h="40.0" x="5189.5" y="1364.0"/> <glyph class="state variable" id="_8bb7bfba-e717-440f-9e3a-7c2adb234d5d"> <state value="P" variable="S166"/> <bbox w="35.0" h="10.0" x="5172.0" y="1359.9303"/> </glyph> <glyph class="state variable" id="_00f3021e-ea90-42ec-b3e4-0ae7dc1bd518"> <state value="P" variable="S186"/> <bbox w="35.0" h="10.0" x="5252.0" y="1359.991"/> </glyph> <glyph class="state variable" id="_f0fc8d1c-2835-478e-b437-5c0a5b8a6e8d"> <state value="" variable="S188"/> <bbox w="30.0" h="10.0" x="5253.882" y="1399.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s519_akt1_akt1_sa350" compartmentRef="akt1_akt1_c2_akt1_akt1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re119(MAP:survival): PMID:15169778 PMID:11923280 PMID:11715018 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 References_end Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 GENECARDS:MDM2 REACTOME:95018 KEGG:4193 ATLASONC:MDM2ID115ch12q15 WIKI:MDM2 Mdm2 p53 binding protein homolog (mouse) Mdm2 p53 binding protein homo Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:CYCLINB MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 PMID:20679392 PMID:15169778 PMID:11923280 PMID:11715018 References_end Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 GENECARDS:MDM2 REACTOME:95018 KEGG:4193 ATLASONC:MDM2ID115ch12q15 WIKI:MDM2 Mdm2 p53 binding protein homolog (mouse) Mdm2 p53 binding protein homo Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:CYCLINB MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 PMID:20679392 PMID:15169778 PMID:11923280 PMID:11715018 References_end</body> </html> </notes> <label text="MDM2"/> <bbox w="80.0" h="40.0" x="5189.5" y="1446.0"/> <glyph class="state variable" id="_c97c27d6-d6da-4dba-b646-0bcd50eed997"> <state value="P" variable="S166"/> <bbox w="35.0" h="10.0" x="5172.0" y="1441.9303"/> </glyph> <glyph class="state variable" id="_6a01dc66-f11f-4bab-b80c-f7647cc77bee"> <state value="P" variable="S186"/> <bbox w="35.0" h="10.0" x="5252.0" y="1441.991"/> </glyph> <glyph class="state variable" id="_b3bca810-16c8-4303-8d94-547e811379c6"> <state value="P" variable="S188"/> <bbox w="35.0" h="10.0" x="5251.382" y="1481.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s538_akt1_akt1_sa357" compartmentRef="akt1_akt1_c5_akt1_akt1_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re124:(MAP:survival) PMID:10949026 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="6693.5" y="829.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s558_akt1_akt1_sa366" compartmentRef="akt1_akt1_c5_akt1_akt1_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re127:(MAP:survival) PMID:10949026 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 1BCL2-associated agonist of cell death HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 GENECARDS:BCL2L1 REACTOME:50772 KEGG:598 ATLASONC:BCL2L1ID129ch20q11 WIKI:BCL2L1 BCL2-like 1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:10949026 PMID:18097445 References_end Identifiers_begin: BCL2-like 1BCL2-associated agonist of cell death HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 GENECARDS:BCL2L1 REACTOME:50772 KEGG:598 ATLASONC:BCL2L1ID129ch20q11 WIKI:BCL2L1 BCL2-like 1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:10949026 PMID:18097445 References_end</body> </html> </notes> <label text="BCL2-XL*"/> <bbox w="80.0" h="40.0" x="6438.5" y="774.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s564_akt1_akt1_sa370" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Nitric oxide synthase 3 HUGO:NOS3 HGNC:7876 ENTREZ:4846 UNIPROT:P29474 GENECARDS:NOS3 REACTOME:60353 KEGG:4846 ATLASONC:GC_NOS3 WIKI:NOS3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16489074 References_end</body> </html> </notes> <label text="ENOS*"/> <bbox w="80.0" h="40.0" x="6183.0" y="383.5"/> <glyph class="state variable" id="_760cc8fa-a07d-4f2d-903a-2ac98e5fe4c4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6258.0" y="378.5"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s565_akt1_akt1_sa371" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Nitric oxide synthase 3 HUGO:NOS3 HGNC:7876 ENTREZ:4846 UNIPROT:P29474 GENECARDS:NOS3 REACTOME:60353 KEGG:4846 ATLASONC:GC_NOS3 WIKI:NOS3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16489074 References_end</body> </html> </notes> <label text="ENOS*"/> <bbox w="80.0" h="40.0" x="6183.0" y="462.5"/> <glyph class="state variable" id="_e533add0-15a7-43e2-85eb-e5cc4cd46ae7"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="6255.5" y="457.5"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s568_akt1_akt1_sa374" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: caspase 9 apoptosis-related cysteine peptidase "caspase 9 apoptosis-related cysteine protease" HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Caspase9 is phosphorylated on Thr125 in a MEK1/2-dependent manner in vivo. Furthermore caspase9 is efficiently phosphorylated on Thr125 by ERK in vitro suggesting that it is targeted directly by ERK in vivo. This is one of the ways ERK plays its anti-apoptotic role. PMID:12792650 References_end Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 GENECARDS:CASP9 REACTOME:57034 KEGG:842 ATLASONC:CASP9ID423ch1p36 WIKI:CASP9 "caspase 9 apoptosis-related cysteine protease" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19788417 PMID:16977332 Caspase9 is phosphorylated on Thr125 in a MEK1/2-dependent manner in vivo. Furthermore caspase9 is efficiently phosphorylated on Thr125 by ERK in vitro suggesting that it is targeted directly by ERK in vivo. This is one of the ways ERK plays its anti-apoptotic role. PMID:12792650 References_end</body> </html> Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 GENECARDS:CASP9 REACTOME:57034 KEGG:842 ATLASONC:CASP9ID423ch1p36 WIKI:CASP9 "caspase 9 apoptosis-related cysteine protease" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19788417 PMID:16977332 Caspase9 is phosphorylated on Thr125 in a MEK1/2-dependent manner in vivo. Furthermore caspase9 is efficiently phosphorylated on Thr125 by ERK in vitro suggesting that it is targeted directly by ERK in vivo. This is one of the ways ERK plays its anti-apoptotic role. PMID:12792650 References_end</body> </html> </notes> <label text="Caspase9*"/> <bbox w="80.0" h="40.0" x="6086.0" y="827.0"/> <glyph class="state variable" id="_bc0a0e7d-4fb7-45f9-843d-21b40a259bcd"> <state value="" variable="S196"/> <bbox w="30.0" h="10.0" x="6151.0" y="822.99097"/> </glyph> <glyph class="state variable" id="_93d309fe-9ff9-4507-b3b7-331f210cd8c4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6081.0" y="842.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s569_akt1_akt1_sa375" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re134:(MAP:survival) PMID:9812896 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 9 apoptosis-related cysteine peptidase "caspase 9 apoptosis-related cysteine protease" HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Caspase9 is phosphorylated on Thr125 in a MEK1/2-dependent manner in vivo. Furthermore caspase9 is efficiently phosphorylated on Thr125 by ERK in vitro suggesting that it is targeted directly by ERK in vivo. This is one of the ways ERK plays its anti-apoptotic role. PMID:12792650 References_end Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 GENECARDS:CASP9 REACTOME:57034 KEGG:842 ATLASONC:CASP9ID423ch1p36 WIKI:CASP9 "caspase 9 apoptosis-related cysteine protease" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19788417 PMID:16977332 Caspase9 is phosphorylated on Thr125 in a MEK1/2-dependent manner in vivo. Furthermore caspase9 is efficiently phosphorylated on Thr125 by ERK in vitro suggesting that it is targeted directly by ERK in vivo. This is one of the ways ERK plays its anti-apoptotic role. PMID:12792650 References_end Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 GENECARDS:CASP9 REACTOME:57034 KEGG:842 ATLASONC:CASP9ID423ch1p36 WIKI:CASP9 "caspase 9 apoptosis-related cysteine protease" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19788417 PMID:16977332 Caspase9 is phosphorylated on Thr125 in a MEK1/2-dependent manner in vivo. Furthermore caspase9 is efficiently phosphorylated on Thr125 by ERK in vitro suggesting that it is targeted directly by ERK in vivo. This is one of the ways ERK plays its anti-apoptotic role. PMID:12792650 References_end</body> </html> </notes> <label text="Caspase9*"/> <bbox w="80.0" h="40.0" x="6235.5" y="708.0"/> <glyph class="state variable" id="_c331b78f-7300-41de-aead-1ed1a2c4c5dd"> <state value="P" variable="S196"/> <bbox w="35.0" h="10.0" x="6298.0" y="703.99097"/> </glyph> <glyph class="state variable" id="_aeefd94f-2f0e-4c81-9389-6e32ccc5d580"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6230.5" y="723.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s570_akt1_akt1_sa376" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re132(MAP:survival): PMID:19788417 PMID:16977332 s_akt1_re187:(MAP:survival) PMID:9765224 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 9 apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 GENECARDS:CASP9 REACTOME:57034 KEGG:842 ATLASONC:CASP9ID423ch1p36 WIKI:CASP9 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19788417 PMID:16977332 References_end</body> </html> </notes> <label text="Caspase9_TRUNC*"/> <bbox w="80.0" h="40.0" x="6189.0" y="827.0"/> <glyph class="unit of information" id="_000aaad7-fcf8-414b-881f-8e3197e0e713"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="6204.0" y="822.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s602_akt1_akt1_sa41" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re145:(MAP:survival) PMID:11313945 PMID:11940581 s_akt1_re11(MAP:survival): PMID:15584861 PMID:10648629 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: GRB2-associated binding protein 1 HUGO:GAB1 HGNC:4066 ENTREZ:2549 UNIPROT:Q13480 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: GRB2-associated binding protein 1 HUGO:GAB1 HGNC:4066 ENTREZ:2549 UNIPROT:Q13480 GENECARDS:GAB1 REACTOME:147726 ATLASONC:GC_GAB1 WIKI:GAB1 GRB2-associated binding protein 2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11313945 PMID:11940581 References_end</body> </html> </notes> <label text="GAB1"/> <bbox w="80.0" h="40.0" x="6357.0" y="529.0"/> <glyph class="state variable" id="_d8438a55-0d06-4d44-bb05-6c3eca085c68"> <state value="P" variable="Y977"/> <bbox w="35.0" h="10.0" x="6339.9927" y="524.0"/> </glyph> <glyph class="state variable" id="_86279a93-6883-456f-b44d-adce3e458eb2"> <state value="P" variable="Y989"/> <bbox w="35.0" h="10.0" x="6419.5" y="524.2148"/> </glyph> <glyph class="state variable" id="_5e9eefa2-bbcf-4695-8014-8b5fad294959"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6352.0" y="544.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s603_akt1_akt1_sa399" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: protein kinase C alpha PKCA HUGO:PRKCA HGNC:9393 ENTREZ:5578 UNIPROT:P17252 protein kinase C beta PKCB PRKCB1 PRKCB2 "protein kinase C beta 1" HUGO:PRKCB HGNC:9395 ENTREZ:5579 UNIPROT:P05771 protein kinase C gamma PKCG SCA14 HUGO:PRKCG HGNC:9402 ENTREZ:5582 UNIPROT:P05129 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity. PMID:15567848 References_end Identifiers_begin: protein kinase C alpha PKCA HUGO:PRKCA HGNC:9393 ENTREZ:5578 UNIPROT:P17252 GENECARDS:PRKCA REACTOME:58197 KEGG:5578 ATLASONC:GC_PRKCA WIKI:PRKCA protein kinase C beta PKCB PRKCB1 PRKCB2 "protein kinase C beta 1" HUGO:PRKCB HGNC:9395 ENTREZ:5579 UNIPROT:P05771 GENECARDS:PRKCB REACTOME:58199 KEGG:5579 ATLASONC:GC_PRKCB WIKI:PRKCB protein kinase C gamma PKCG SCA14 HUGO:PRKCG HGNC:9402 ENTREZ:5582 UNIPROT:P05129 GENECARDS:PRKCG REACTOME:58205 KEGG:5582 ATLASONC:GC_PRKCG WIKI:PRKCG protein kinase C, delta HUGO:PRKCD HGNC:9399 ENTREZ:5580 UNIPROT:Q05655 GENECARDS:PRKCD REACTOME:58201 KEGG:5580 ATLASONC:PRKCDID42901ch3p21 WIKI:PRKCD protein kinase C, epsilon HUGO:PRKCE HGNC:9401 ENTREZ:5581 UNIPROT:Q02156 GENECARDS:PRKCE REACTOME:58203 KEGG:5581 ATLASONC:GC_PRKCE WIKI:PRKCE protein kinase C, eta HUGO:PRKCH HGNC:9403 ENTREZ:5583 UNIPROT:P24723 GENECARDS:PRKCH REACTOME:58209 KEGG:5583 ATLASONC:GC_PRKCH WIKI:PRKCH protein kinase C, iota HUGO:PRKCI HGNC:9404 ENTREZ:5584 UNIPROT:P41743 GENECARDS:PRKCI REACTOME:58207 KEGG:5584 ATLASONC:PRKCIID41857ch3q26 WIKI:PRKCI protein kinase C, theta HUGO:PRKCQ HGNC:9410 ENTREZ:5588 UNIPROT:Q04759 GENECARDS:PRKCQ REACTOME:58217 KEGG:5588 ATLASONC:GC_PRKCQ WIKI:PRKCQ Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity. PMID:15567848 PMID:11313945 PMID:11940581 Only PKC alpha and delta PMID:21386996 References_end</body> </html> Identifiers_begin: protein kinase C alpha PKCA HUGO:PRKCA HGNC:9393 ENTREZ:5578 UNIPROT:P17252 GENECARDS:PRKCA REACTOME:58197 KEGG:5578 ATLASONC:GC_PRKCA WIKI:PRKCA protein kinase C beta PKCB PRKCB1 PRKCB2 "protein kinase C beta 1" HUGO:PRKCB HGNC:9395 ENTREZ:5579 UNIPROT:P05771 GENECARDS:PRKCB REACTOME:58199 KEGG:5579 ATLASONC:GC_PRKCB WIKI:PRKCB protein kinase C gamma PKCG SCA14 HUGO:PRKCG HGNC:9402 ENTREZ:5582 UNIPROT:P05129 GENECARDS:PRKCG REACTOME:58205 KEGG:5582 ATLASONC:GC_PRKCG WIKI:PRKCG protein kinase C, delta HUGO:PRKCD HGNC:9399 ENTREZ:5580 UNIPROT:Q05655 GENECARDS:PRKCD REACTOME:58201 KEGG:5580 ATLASONC:PRKCDID42901ch3p21 WIKI:PRKCD protein kinase C, epsilon HUGO:PRKCE HGNC:9401 ENTREZ:5581 UNIPROT:Q02156 GENECARDS:PRKCE REACTOME:58203 KEGG:5581 ATLASONC:GC_PRKCE WIKI:PRKCE protein kinase C, eta HUGO:PRKCH HGNC:9403 ENTREZ:5583 UNIPROT:P24723 GENECARDS:PRKCH REACTOME:58209 KEGG:5583 ATLASONC:GC_PRKCH WIKI:PRKCH protein kinase C, iota HUGO:PRKCI HGNC:9404 ENTREZ:5584 UNIPROT:P41743 GENECARDS:PRKCI REACTOME:58207 KEGG:5584 ATLASONC:PRKCIID41857ch3q26 WIKI:PRKCI protein kinase C, theta HUGO:PRKCQ HGNC:9410 ENTREZ:5588 UNIPROT:Q04759 GENECARDS:PRKCQ REACTOME:58217 KEGG:5588 ATLASONC:GC_PRKCQ WIKI:PRKCQ Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity. PMID:15567848 PMID:11313945 PMID:11940581 Only PKC alpha and delta PMID:21386996 References_end</body> </html> </notes> <label text="PKC*"/> <bbox w="80.0" h="40.0" x="6268.0" y="597.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s609_akt1_akt1_sa400" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re147(MAP:survival): PMID:11707428 phospho- rylation of the PTEN tail negatively regulates PTEN activity PMID:11035045 phosphorylation of PTEN by CK2 is important for PTEN protein stability to proteasome-mediated degradation References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end</body> </html> </notes> <label text="PTEN"/> <bbox w="80.0" h="40.0" x="5325.5" y="901.0"/> <glyph class="state variable" id="_d570b21f-bd61-473b-873d-6c5a10714192"> <state value="P" variable="S380"/> <bbox w="35.0" h="10.0" x="5358.2476" y="896.0"/> </glyph> <glyph class="state variable" id="_878b9c0f-d818-4a78-8341-52b565a2f4f8"> <state value="P" variable="S370"/> <bbox w="35.0" h="10.0" x="5387.6333" y="896.0"/> </glyph> <glyph class="state variable" id="_b6eab4ce-9ece-4367-a74d-06503e7e081f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5400.5" y="936.0"/> </glyph> <glyph class="state variable" id="_22b0d14d-7176-4b46-a8c6-467914d8fec7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5320.5" y="936.0"/> </glyph> <glyph class="state variable" id="_564a3a2c-4fb3-4cff-b61a-f5e92c2ae0df"> <state value="" variable="K289"/> <bbox w="30.0" h="10.0" x="5351.2046" y="936.0"/> </glyph> <glyph class="state variable" id="_69453010-c225-4c84-b98c-6426d1eddd22"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5320.5" y="896.0"/> </glyph> <glyph class="state variable" id="_85d9600c-8361-4996-a7ef-67761f0cf16a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5400.5" y="896.0"/> </glyph> <glyph class="state variable" id="_676fa6b9-e28b-444b-b46f-a27a0afdb71d"> <state value="" variable="K13"/> <bbox w="25.0" h="10.0" x="5313.24" y="936.0"/> </glyph> <glyph class="state variable" id="_61ba7d9a-f3d8-4920-b5f8-c74ebfc641d8"> <state value="P" variable="S385"/> <bbox w="35.0" h="10.0" x="5308.0" y="915.96814"/> </glyph> <glyph class="state variable" id="_7e50d795-1bda-4103-bf89-2e9d50d55de0"> <state value="" variable="T366"/> <bbox w="30.0" h="10.0" x="5390.5" y="916.0"/> </glyph> <glyph class="state variable" id="_2356ba12-2862-4e01-a62d-3e4cb414cb53"> <state value="P" variable="T383"/> <bbox w="35.0" h="10.0" x="5308.0" y="898.4022"/> </glyph> <glyph class="state variable" id="_ef06d130-5e91-4903-b64d-4ee87ba12dc6"> <state value="P" variable="T382"/> <bbox w="35.0" h="10.0" x="5336.532" y="896.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s615_akt1_akt1_sa413" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re160:(MAP:survival) PMID:19797085 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PH domain and leucine rich repeat protein phosphatase 1 HUGO:PHLPP1 HGNC:20610 ENTREZ:23239 UNIPROT:O60346 GENECARDS:PHLPP1 REACTOME:199433 KEGG:23239 ATLASONC:PHLPP1ID44544ch18q21 WIKI:PHLPP1 O60346 PH domain and leucine rich repeat protein phosphatase 2 HUGO:PHLPP2 HGNC:29149 ENTREZ:23035 UNIPROT:Q6ZVD8 GENECARDS:PHLPP2 REACTOME:242675 KEGG:23035 ATLASONC:PHLPP2ID44546ch16q22 WIKI:PHLPP2 Q6ZVD8 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15808505 PMID:19797085 PMID:18511290 References_end</body> </html> </notes> <label text="PHLPP*"/> <bbox w="80.0" h="40.0" x="5957.5" y="734.0"/> <glyph class="state variable" id="_cc5ec435-f62f-43e2-af96-66bc271ae99c"> <state value="P" variable="S869"/> <bbox w="35.0" h="10.0" x="6020.0" y="729.2148"/> </glyph> <glyph class="state variable" id="_6c9115a0-a361-40d0-8359-25e07a9e25ea"> <state value="P" variable="S847"/> <bbox w="35.0" h="10.0" x="5940.4927" y="729.0"/> </glyph> <glyph class="state variable" id="_a6ec6506-a8ef-4dcc-b528-7fb35b7ead31"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5952.5" y="749.0"/> </glyph> <glyph class="state variable" id="_2675326d-519d-49b7-878c-2733163c777c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6032.5" y="740.7157"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s616_akt1_akt1_sa414" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re158:(MAP:survival) PMID:19797085 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PH domain and leucine rich repeat protein phosphatase 1 HUGO:PHLPP1 HGNC:20610 ENTREZ:23239 UNIPROT:O60346 GENECARDS:PHLPP1 REACTOME:199433 KEGG:23239 ATLASONC:PHLPP1ID44544ch18q21 WIKI:PHLPP1 O60346 PH domain and leucine rich repeat protein phosphatase 2 HUGO:PHLPP2 HGNC:29149 ENTREZ:23035 UNIPROT:Q6ZVD8 GENECARDS:PHLPP2 REACTOME:242675 KEGG:23035 ATLASONC:PHLPP2ID44546ch16q22 WIKI:PHLPP2 Q6ZVD8 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15808505 PMID:19797085 PMID:18511290 References_end</body> </html> </notes> <label text="PHLPP*"/> <bbox w="80.0" h="40.0" x="6122.5" y="734.0"/> <glyph class="state variable" id="_fabdad3a-5090-4357-8e89-080faa697a6b"> <state value="P" variable="S869"/> <bbox w="35.0" h="10.0" x="6185.0" y="729.2148"/> </glyph> <glyph class="state variable" id="_71d0990d-b47d-42f2-9902-dcc2b02303fa"> <state value="P" variable="S847"/> <bbox w="35.0" h="10.0" x="6105.4927" y="729.0"/> </glyph> <glyph class="state variable" id="_d698321e-11b1-41ba-afb4-446569a3276f"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="6112.5" y="749.0"/> </glyph> <glyph class="state variable" id="_efe005cd-a08e-48ea-8921-b3683abc88ff"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="6192.5" y="740.7157"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s617_akt1_akt1_sa415" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re159:(MAP:survival) PMID:19797085 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PH domain and leucine rich repeat protein phosphatase 1 HUGO:PHLPP1 HGNC:20610 ENTREZ:23239 UNIPROT:O60346 GENECARDS:PHLPP1 REACTOME:199433 KEGG:23239 ATLASONC:PHLPP1ID44544ch18q21 WIKI:PHLPP1 O60346 PH domain and leucine rich repeat protein phosphatase 2 HUGO:PHLPP2 HGNC:29149 ENTREZ:23035 UNIPROT:Q6ZVD8 GENECARDS:PHLPP2 REACTOME:242675 KEGG:23035 ATLASONC:PHLPP2ID44546ch16q22 WIKI:PHLPP2 Q6ZVD8 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15808505 PMID:19797085 PMID:18511290 References_end</body> </html> </notes> <label text="PHLPP*"/> <bbox w="80.0" h="40.0" x="5802.75" y="734.0"/> <glyph class="state variable" id="_a8afd0e3-4918-4272-9021-8a4b0b9295c7"> <state value="P" variable="S869"/> <bbox w="35.0" h="10.0" x="5865.25" y="729.2148"/> </glyph> <glyph class="state variable" id="_cbd02d11-72b1-46e6-86b4-293919d39a63"> <state value="" variable="S847"/> <bbox w="30.0" h="10.0" x="5788.2427" y="729.0"/> </glyph> <glyph class="state variable" id="_c201ba91-0932-46d2-890f-3322b006e4b9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5797.75" y="749.0"/> </glyph> <glyph class="state variable" id="_453cd5f4-7be3-43ff-a191-19dacb2e50ae"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5877.75" y="740.7157"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s623_akt1_akt1_sa424" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C ubiquitin-conjugating enzyme E2D 1 HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 ubiquitin-conjugating enzyme E2E 1 HUGO:UBE2E1 HGNC:12477 ENTREZ:7324 UNIPROT:P51965 GENECARDS:UBE2E1 REACTOME:66739 KEGG:7324 ATLASONC:GC_UBE2E1 WIKI:UBE2E1 ubiquitin-conjugating enzyme E2E 2 HUGO:UBE2E2 HGNC:12478 ENTREZ:7325 UNIPROT:Q96LR5 GENECARDS:UBE2E2 REACTOME:155471 KEGG:7325 ATLASONC:GC_UBE2E2 WIKI:UBE2E2 ubiquitin-conjugating enzyme E2G 1 HUGO:UBE2G1 HGNC:12482 ENTREZ:7326 UNIPROT:P62253 GENECARDS:UBE2G1 REACTOME:66753 KEGG:7326 ATLASONC:GC_UBE2G1 WIKI:UBE2G1 ubiquitin-conjugating enzyme E2G 2 HUGO:UBE2G2 HGNC:12483 ENTREZ:7327 UNIPROT:P60604 GENECARDS:UBE2G2 REACTOME:66773 KEGG:7327 ATLASONC:GC_UBE2G2 WIKI:UBE2G2 ubiquitin-conjugating enzyme E2H HUGO:UBE2H HGNC:12484 ENTREZ:7328 UNIPROT:P62256 GENECARDS:UBE2H REACTOME:66759 KEGG:7328 ATLASONC:GC_UBE2H WIKI:UBE2H ubiquitin-conjugating enzyme E2I HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I ubiquitin-conjugating enzyme E2 J1 HUGO:UBE2J1 HGNC:17598 ENTREZ:51465 UNIPROT:Q9Y385 GENECARDS:UBE2J1 REACTOME:155484 KEGG:51465 ATLASONC:GC_UBE2J1 WIKI:UBE2J1 ubiquitin-conjugating enzyme E2 J2 HUGO:UBE2J2 HGNC:19268 ENTREZ:118424 UNIPROT:Q8N2K1 GENECARDS:UBE2J2 REACTOME:155486 KEGG:118424 WIKI:UBE2J2 ubiquitin-conjugating enzyme E2K HUGO:UBE2K HGNC:4914 ENTREZ:3093 UNIPROT:P61086 GENECARDS:UBE2K REACTOME:66723 KEGG:3093 WIKI:UBE2K ubiquitin-conjugating enzyme E2L 3 HUGO:UBE2L3 HGNC:12488 ENTREZ:7332 UNIPROT:P68036 GENECARDS:UBE2L3 REACTOME:66741 KEGG:7332 ATLASONC:GC_UBE2L3 WIKI:UBE2L3 ubiquitin-conjugating enzyme E2L 4 HUGO:UBE2L4 HGNC:12489 ENTREZ:7333 GENECARDS:UBE2L4 WIKI:UBE2L4 ubiquitin-conjugating enzyme E2L 6 HUGO:UBE2L6 HGNC:12490 ENTREZ:9246 UNIPROT:O14933 GENECARDS:UBE2L6 REACTOME:66745 KEGG:9246 ATLASONC:GC_UBE2L6 WIKI:UBE2L6 ubiquitin-conjugating enzyme E2M HUGO:UBE2M HGNC:12491 ENTREZ:9040 UNIPROT:P61081 GENECARDS:UBE2M REACTOME:66777 KEGG:9040 ATLASONC:GC_UBE2M WIKI:UBE2M ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 GENECARDS:UBE2N REACTOME:66781 KEGG:7334 ATLASONC:GC_UBE2N WIKI:UBE2N ubiquitin-conjugating enzyme E2O HUGO:UBE2O HGNC:29554 ENTREZ:63893 UNIPROT:Q9C0C9 GENECARDS:UBE2O REACTOME:253534 KEGG:63893 ATLASONC:GC_UBE2O WIKI:UBE2O ubiquitin-conjugating enzyme E2Q family member 1 HUGO:UBE2Q1 HGNC:15698 ENTREZ:55585 UNIPROT:Q7Z7E8 GENECARDS:UBE2Q1 REACTOME:253474 KEGG:55585 ATLASONC:GC_UBE2Q1 WIKI:UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 2 HUGO:UBE2Q2 HGNC:19248 ENTREZ:92912 UNIPROT:Q8WVN8 GENECARDS:UBE2Q2 REACTOME:253479 ATLASONC:GC_UBE2Q2 WIKI:UBE2Q2 ubiquitin-conjugating enzyme E2R 2 HUGO:UBE2R2 HGNC:19907 ENTREZ:54926 UNIPROT:Q712K3 GENECARDS:UBE2R2 REACTOME:253483 KEGG:54926 ATLASONC:GC_UBE2R2 WIKI:UBE2R2 ubiquitin-conjugating enzyme E2S HUGO:UBE2S HGNC:17895 ENTREZ:27338 UNIPROT:Q16763 GENECARDS:UBE2S REACTOME:66751 KEGG:27338 ATLASONC:GC_UBE2S WIKI:UBE2S ubiquitin-conjugating enzyme E2Z HUGO:UBE2Z HGNC:25847 ENTREZ:65264 UNIPROT:Q9H832 GENECARDS:UBE2Z REACTOME:253545 KEGG:65264 WIKI:UBE2Z Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C ubiquitin-conjugating enzyme E2D 1 HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 ubiquitin-conjugating enzyme E2E 1 HUGO:UBE2E1 HGNC:12477 ENTREZ:7324 UNIPROT:P51965 GENECARDS:UBE2E1 REACTOME:66739 KEGG:7324 ATLASONC:GC_UBE2E1 WIKI:UBE2E1 ubiquitin-conjugating enzyme E2E 2 HUGO:UBE2E2 HGNC:12478 ENTREZ:7325 UNIPROT:Q96LR5 GENECARDS:UBE2E2 REACTOME:155471 KEGG:7325 ATLASONC:GC_UBE2E2 WIKI:UBE2E2 ubiquitin-conjugating enzyme E2G 1 HUGO:UBE2G1 HGNC:12482 ENTREZ:7326 UNIPROT:P62253 GENECARDS:UBE2G1 REACTOME:66753 KEGG:7326 ATLASONC:GC_UBE2G1 WIKI:UBE2G1 ubiquitin-conjugating enzyme E2G 2 HUGO:UBE2G2 HGNC:12483 ENTREZ:7327 UNIPROT:P60604 GENECARDS:UBE2G2 REACTOME:66773 KEGG:7327 ATLASONC:GC_UBE2G2 WIKI:UBE2G2 ubiquitin-conjugating enzyme E2H HUGO:UBE2H HGNC:12484 ENTREZ:7328 UNIPROT:P62256 GENECARDS:UBE2H REACTOME:66759 KEGG:7328 ATLASONC:GC_UBE2H WIKI:UBE2H ubiquitin-conjugating enzyme E2I HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I ubiquitin-conjugating enzyme E2 J1 HUGO:UBE2J1 HGNC:17598 ENTREZ:51465 UNIPROT:Q9Y385 GENECARDS:UBE2J1 REACTOME:155484 KEGG:51465 ATLASONC:GC_UBE2J1 WIKI:UBE2J1 ubiquitin-conjugating enzyme E2 J2 HUGO:UBE2J2 HGNC:19268 ENTREZ:118424 UNIPROT:Q8N2K1 GENECARDS:UBE2J2 REACTOME:155486 KEGG:118424 WIKI:UBE2J2 ubiquitin-conjugating enzyme E2K HUGO:UBE2K HGNC:4914 ENTREZ:3093 UNIPROT:P61086 GENECARDS:UBE2K REACTOME:66723 KEGG:3093 WIKI:UBE2K ubiquitin-conjugating enzyme E2L 3 HUGO:UBE2L3 HGNC:12488 ENTREZ:7332 UNIPROT:P68036 GENECARDS:UBE2L3 REACTOME:66741 KEGG:7332 ATLASONC:GC_UBE2L3 WIKI:UBE2L3 ubiquitin-conjugating enzyme E2L 4 HUGO:UBE2L4 HGNC:12489 ENTREZ:7333 GENECARDS:UBE2L4 WIKI:UBE2L4 ubiquitin-conjugating enzyme E2L 6 HUGO:UBE2L6 HGNC:12490 ENTREZ:9246 UNIPROT:O14933 GENECARDS:UBE2L6 REACTOME:66745 KEGG:9246 ATLASONC:GC_UBE2L6 WIKI:UBE2L6 ubiquitin-conjugating enzyme E2M HUGO:UBE2M HGNC:12491 ENTREZ:9040 UNIPROT:P61081 GENECARDS:UBE2M REACTOME:66777 KEGG:9040 ATLASONC:GC_UBE2M WIKI:UBE2M ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 GENECARDS:UBE2N REACTOME:66781 KEGG:7334 ATLASONC:GC_UBE2N WIKI:UBE2N ubiquitin-conjugating enzyme E2O HUGO:UBE2O HGNC:29554 ENTREZ:63893 UNIPROT:Q9C0C9 GENECARDS:UBE2O REACTOME:253534 KEGG:63893 ATLASONC:GC_UBE2O WIKI:UBE2O ubiquitin-conjugating enzyme E2Q family member 1 HUGO:UBE2Q1 HGNC:15698 ENTREZ:55585 UNIPROT:Q7Z7E8 GENECARDS:UBE2Q1 REACTOME:253474 KEGG:55585 ATLASONC:GC_UBE2Q1 WIKI:UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 2 HUGO:UBE2Q2 HGNC:19248 ENTREZ:92912 UNIPROT:Q8WVN8 GENECARDS:UBE2Q2 REACTOME:253479 ATLASONC:GC_UBE2Q2 WIKI:UBE2Q2 ubiquitin-conjugating enzyme E2R 2 HUGO:UBE2R2 HGNC:19907 ENTREZ:54926 UNIPROT:Q712K3 GENECARDS:UBE2R2 REACTOME:253483 KEGG:54926 ATLASONC:GC_UBE2R2 WIKI:UBE2R2 ubiquitin-conjugating enzyme E2S HUGO:UBE2S HGNC:17895 ENTREZ:27338 UNIPROT:Q16763 GENECARDS:UBE2S REACTOME:66751 KEGG:27338 ATLASONC:GC_UBE2S WIKI:UBE2S ubiquitin-conjugating enzyme E2Z HUGO:UBE2Z HGNC:25847 ENTREZ:65264 UNIPROT:Q9H832 GENECARDS:UBE2Z REACTOME:253545 KEGG:65264 WIKI:UBE2Z Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C ubiquitin-conjugating enzyme E2D 1 HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 ubiquitin-conjugating enzyme E2E 1 HUGO:UBE2E1 HGNC:12477 ENTREZ:7324 UNIPROT:P51965 GENECARDS:UBE2E1 REACTOME:66739 KEGG:7324 ATLASONC:GC_UBE2E1 WIKI:UBE2E1 ubiquitin-conjugating enzyme E2E 2 HUGO:UBE2E2 HGNC:12478 ENTREZ:7325 UNIPROT:Q96LR5 GENECARDS:UBE2E2 REACTOME:155471 KEGG:7325 ATLASONC:GC_UBE2E2 WIKI:UBE2E2 ubiquitin-conjugating enzyme E2G 1 HUGO:UBE2G1 HGNC:12482 ENTREZ:7326 UNIPROT:P62253 GENECARDS:UBE2G1 REACTOME:66753 KEGG:7326 ATLASONC:GC_UBE2G1 WIKI:UBE2G1 ubiquitin-conjugating enzyme E2G 2 HUGO:UBE2G2 HGNC:12483 ENTREZ:7327 UNIPROT:P60604 GENECARDS:UBE2G2 REACTOME:66773 KEGG:7327 ATLASONC:GC_UBE2G2 WIKI:UBE2G2 ubiquitin-conjugating enzyme E2H HUGO:UBE2H HGNC:12484 ENTREZ:7328 UNIPROT:P62256 GENECARDS:UBE2H REACTOME:66759 KEGG:7328 ATLASONC:GC_UBE2H WIKI:UBE2H ubiquitin-conjugating enzyme E2I HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I ubiquitin-conjugating enzyme E2 J1 HUGO:UBE2J1 HGNC:17598 ENTREZ:51465 UNIPROT:Q9Y385 GENECARDS:UBE2J1 REACTOME:155484 KEGG:51465 ATLASONC:GC_UBE2J1 WIKI:UBE2J1 ubiquitin-conjugating enzyme E2 J2 HUGO:UBE2J2 HGNC:19268 ENTREZ:118424 UNIPROT:Q8N2K1 GENECARDS:UBE2J2 REACTOME:155486 KEGG:118424 WIKI:UBE2J2 ubiquitin-conjugating enzyme E2K HUGO:UBE2K HGNC:4914 ENTREZ:3093 UNIPROT:P61086 GENECARDS:UBE2K REACTOME:66723 KEGG:3093 WIKI:UBE2K ubiquitin-conjugating enzyme E2L 3 HUGO:UBE2L3 HGNC:12488 ENTREZ:7332 UNIPROT:P68036 GENECARDS:UBE2L3 REACTOME:66741 KEGG:7332 ATLASONC:GC_UBE2L3 WIKI:UBE2L3 ubiquitin-conjugating enzyme E2L 4 HUGO:UBE2L4 HGNC:12489 ENTREZ:7333 GENECARDS:UBE2L4 WIKI:UBE2L4 ubiquitin-conjugating enzyme E2L 6 HUGO:UBE2L6 HGNC:12490 ENTREZ:9246 UNIPROT:O14933 GENECARDS:UBE2L6 REACTOME:66745 KEGG:9246 ATLASONC:GC_UBE2L6 WIKI:UBE2L6 ubiquitin-conjugating enzyme E2M HUGO:UBE2M HGNC:12491 ENTREZ:9040 UNIPROT:P61081 GENECARDS:UBE2M REACTOME:66777 KEGG:9040 ATLASONC:GC_UBE2M WIKI:UBE2M ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 GENECARDS:UBE2N REACTOME:66781 KEGG:7334 ATLASONC:GC_UBE2N WIKI:UBE2N ubiquitin-conjugating enzyme E2O HUGO:UBE2O HGNC:29554 ENTREZ:63893 UNIPROT:Q9C0C9 GENECARDS:UBE2O REACTOME:253534 KEGG:63893 ATLASONC:GC_UBE2O WIKI:UBE2O ubiquitin-conjugating enzyme E2Q family member 1 HUGO:UBE2Q1 HGNC:15698 ENTREZ:55585 UNIPROT:Q7Z7E8 GENECARDS:UBE2Q1 REACTOME:253474 KEGG:55585 ATLASONC:GC_UBE2Q1 WIKI:UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 2 HUGO:UBE2Q2 HGNC:19248 ENTREZ:92912 UNIPROT:Q8WVN8 GENECARDS:UBE2Q2 REACTOME:253479 ATLASONC:GC_UBE2Q2 WIKI:UBE2Q2 ubiquitin-conjugating enzyme E2R 2 HUGO:UBE2R2 HGNC:19907 ENTREZ:54926 UNIPROT:Q712K3 GENECARDS:UBE2R2 REACTOME:253483 KEGG:54926 ATLASONC:GC_UBE2R2 WIKI:UBE2R2 ubiquitin-conjugating enzyme E2S HUGO:UBE2S HGNC:17895 ENTREZ:27338 UNIPROT:Q16763 GENECARDS:UBE2S REACTOME:66751 KEGG:27338 ATLASONC:GC_UBE2S WIKI:UBE2S ubiquitin-conjugating enzyme E2Z HUGO:UBE2Z HGNC:25847 ENTREZ:65264 UNIPROT:Q9H832 GENECARDS:UBE2Z REACTOME:253545 KEGG:65264 WIKI:UBE2Z Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> </notes> <label text="E2*"/> <bbox w="80.0" h="40.0" x="5931.0" y="1037.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s624_akt1_akt1_sa425" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> </notes> <label text="E1*"/> <bbox w="80.0" h="40.0" x="5840.0" y="1037.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s634_akt1_akt1_sa123" compartmentRef="akt1_akt1_c3_akt1_akt1_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re37(MAP:survival): PMID:16636147 ANNOTATION:THE PHOSPHORYLATION STATE OF TSC2 IS NOT OFF INFLUENCE ON THE GTPase ACTIVITY OF THE PROTEIN s_akt1_re169(MAP:survival): Phosphorylation of S939 and S981 by Akt initiates binding of 14-3-3 protein to TSC2 leading to trans References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 GENECARDS:TSC2 REACTOME:404219 KEGG:7249 ATLASONC:TSC2ID184 WIKI:TSC2 P49815 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 GENECARDS:TSC2 REACTOME:404219 KEGG:7249 ATLASONC:TSC2ID184 WIKI:TSC2 P49815 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end</body> </html> </notes> <label text="TSC2"/> <bbox w="80.0" h="40.0" x="6563.722" y="1253.5555"/> <glyph class="state variable" id="_bc8980c3-4be4-4fda-9510-a099d213d0c8"> <state value="P" variable="S1086"/> <bbox w="40.0" h="10.0" x="6623.722" y="1270.0219"/> </glyph> <glyph class="state variable" id="_bf0c0a99-be46-42b1-8895-a2a9d4c0088a"> <state value="P" variable="S981"/> <bbox w="35.0" h="10.0" x="6622.804" y="1248.5555"/> </glyph> <glyph class="state variable" id="_64493446-5327-49e0-b3ff-fc897fca0d0c"> <state value="P" variable="S1130"/> <bbox w="40.0" h="10.0" x="6581.6245" y="1288.5555"/> </glyph> <glyph class="state variable" id="_2918421b-e07b-4ec2-bc16-ed4050b7252d"> <state value="P" variable="T1462"/> <bbox w="40.0" h="10.0" x="6544.215" y="1248.5555"/> </glyph> <glyph class="state variable" id="_dfebb2f2-9284-4af7-be7e-4faf19118baa"> <state value="P" variable="S1132"/> <bbox w="40.0" h="10.0" x="6543.722" y="1287.504"/> </glyph> <glyph class="state variable" id="_fd147292-3873-4682-81ae-d1a5d1ad9a10"> <state value="P" variable="S939"/> <bbox w="35.0" h="10.0" x="6584.2524" y="1248.5555"/> </glyph> <glyph class="state variable" id="_614a9ab7-ed4f-4bb7-aa1e-3ef177b39516"> <state value="P" variable="S1088"/> <bbox w="40.0" h="10.0" x="6623.104" y="1288.5555"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s648_akt1_akt1_sa434" compartmentRef="akt1_akt1_c3_akt1_akt1_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re170:(MAP:survival) PMID:14551205 s_akt1_re45(MAP:survival): PMID:14551205 PMID:17693255 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tuberous sclerosis 1 HUGO:TSC1 HGNC:12362 ENTREZ:7248 UNIPROT:Q92574 GENECARDS:TSC1 REACTOME:66499 KEGG:7248 ATLASONC:TSC1ID183 WIKI:TSC1 Q92574 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end Identifiers_begin: tuberous sclerosis 1 HUGO:TSC1 HGNC:12362 ENTREZ:7248 UNIPROT:Q92574 GENECARDS:TSC1 REACTOME:66499 KEGG:7248 ATLASONC:TSC1ID183 WIKI:TSC1 Q92574 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end</body> </html> </notes> <label text="TSC1"/> <bbox w="80.0" h="40.0" x="6044.8823" y="1209.2941"/> <glyph class="state variable" id="_fd904e70-0991-4056-a64e-f352995da996"> <state value="P" variable="T417"/> <bbox w="35.0" h="10.0" x="6027.875" y="1204.2941"/> </glyph> <glyph class="state variable" id="_8eb8d5b3-9543-4f0b-9976-fa65405d3576"> <state value="" variable="S487"/> <bbox w="30.0" h="10.0" x="6109.8823" y="1204.5088"/> </glyph> <glyph class="state variable" id="_2a274139-d991-40fc-9c00-3244b79e0554"> <state value="P" variable="S584"/> <bbox w="35.0" h="10.0" x="6104.4683" y="1244.2941"/> </glyph> <glyph class="state variable" id="_2ecdb676-f893-4656-87ad-713f0674a56c"> <state value="P" variable="T1047"/> <bbox w="40.0" h="10.0" x="6024.8823" y="1244.0164"/> </glyph> <glyph class="state variable" id="_f967b84f-c676-40ad-9aa3-4d2228ddcc28"> <state value="" variable="S511"/> <bbox w="30.0" h="10.0" x="6109.8823" y="1224.2941"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s649_akt1_akt1_sa435" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re170:(MAP:survival) PMID:14551205 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase 1 HUGO:CDK1 HGNC:1722 ENTREZ:983 UNIPROT:P06493 GENECARDS:CDK1 REACTOME:86981 KEGG:983 ATLASONC:GC_CDK1 WIKI:CDK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:S_CC_PHASE MAP:dnarepair / MODULE:G2_CC_PHASE MAP:dnarepair / MODULE:M_CC_PHASE MAP:cellcycle / MODULE:CYCLINB MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:14551205 PMID:18414028 References_end</body> </html> </notes> <label text="CDK1"/> <bbox w="80.0" h="40.0" x="6119.0" y="1080.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s651_akt1_akt1_sa436" compartmentRef="akt1_akt1_c3_akt1_akt1_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re171:(MAP:survival) PMID:17693255 s_akt1_re45(MAP:survival): PMID:14551205 PMID:17693255 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tuberous sclerosis 1 HUGO:TSC1 HGNC:12362 ENTREZ:7248 UNIPROT:Q92574 GENECARDS:TSC1 REACTOME:66499 KEGG:7248 ATLASONC:TSC1ID183 WIKI:TSC1 Q92574 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end Identifiers_begin: tuberous sclerosis 1 HUGO:TSC1 HGNC:12362 ENTREZ:7248 UNIPROT:Q92574 GENECARDS:TSC1 REACTOME:66499 KEGG:7248 ATLASONC:TSC1ID183 WIKI:TSC1 Q92574 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end</body> </html> </notes> <label text="TSC1"/> <bbox w="80.0" h="40.0" x="6042.8823" y="1282.0"/> <glyph class="state variable" id="_99d5bbc3-f8df-4cb1-94db-becc2e3fb7e6"> <state value="" variable="T417"/> <bbox w="30.0" h="10.0" x="6028.375" y="1277.0"/> </glyph> <glyph class="state variable" id="_7cea04b0-891d-49c6-a0cf-57ff7f513093"> <state value="P" variable="S487"/> <bbox w="35.0" h="10.0" x="6105.3823" y="1277.2147"/> </glyph> <glyph class="state variable" id="_14a19582-5ee7-4685-9153-9838d7565106"> <state value="" variable="S584"/> <bbox w="30.0" h="10.0" x="6104.9683" y="1317.0"/> </glyph> <glyph class="state variable" id="_d91dfa2c-c171-4473-8698-16c6d0b19bde"> <state value="" variable="T1047"/> <bbox w="35.0" h="10.0" x="6025.3823" y="1316.7223"/> </glyph> <glyph class="state variable" id="_40243cb0-e863-402e-91c2-aa78115bb759"> <state value="P" variable="S511"/> <bbox w="35.0" h="10.0" x="6105.3823" y="1297.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s652_akt1_akt1_sa437" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re171:(MAP:survival) PMID:17693255 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta HUGO:IKBKB HGNC:5960 ENTREZ:3551 UNIPROT:O14920 GENECARDS:IKBKB REACTOME:57216 KEGG:3551 ATLASONC:GC_IKBKB WIKI:IKBKB Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20300203 PMID:17693255 PMID:18716620 References_end</body> </html> </notes> <label text="IKKβ*"/> <bbox w="80.0" h="40.0" x="5874.0" y="1138.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s653_akt1_akt1_sa438" compartmentRef="akt1_akt1_c7_akt1_akt1_ca7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re175:(MAP:survival) PMID:18851840 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end</body> </html> </notes> <label text="SYN4*"/> <bbox w="80.0" h="40.0" x="4720.0" y="360.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s674_akt1_akt1_sa455" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re175:(MAP:survival) PMID:18851840 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Protein Kinase C alpha HUGO:PRKCA HGNC:9393 ENTREZ:5578 UNIPROT:P17252 GENECARDS:PRKCA REACTOME:58197 KEGG:5578 ATLASONC:GC_PRKCA WIKI:PRKCA Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20027184 References_end</body> </html> </notes> <label text="PRKCA"/> <bbox w="80.0" h="40.0" x="4536.5" y="333.5"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s675_akt1_akt1_sa35" compartmentRef="akt1_akt1_c7_akt1_akt1_ca7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re7(MAP:survival): PMID:18802401 PMID:17680028 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: 3-phosphoinositide dependent protein kinase-1 HUGO:PDPK1 HGNC:8816 ENTREZ:5170 UNIPROT:O15530 GENECARDS:PDPK1 REACTOME:61460 KEGG:5170 ATLASONC:GC_PDPK1 WIKI:PDPK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18802401 PMID:17680028 References_end</body> </html> </notes> <label text="PDPK1"/> <bbox w="80.0" h="40.0" x="5212.0" y="202.0"/> <glyph class="state variable" id="_516104de-293f-486f-a53c-70776aa6c4e4"> <state value="" variable="S241"/> <bbox w="30.0" h="10.0" x="5236.9043" y="237.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s670_akt1_akt1_sa451" compartmentRef="akt1_akt1_c7_akt1_akt1_ca7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re175:(MAP:survival) PMID:18851840 s_akt1_re174(MAP:survival): PMID:20027184 PMID:21474067 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Protein Kinase C alpha HUGO:PRKCA HGNC:9393 ENTREZ:5578 UNIPROT:P17252 GENECARDS:PRKCA REACTOME:58197 KEGG:5578 ATLASONC:GC_PRKCA WIKI:PRKCA Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20027184 References_end</body> </html> </notes> <label text="PRKCA"/> <bbox w="80.0" h="40.0" x="4823.0" y="333.5"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s676_akt1_akt1_sa291" compartmentRef="akt1_akt1_c7_akt1_akt1_ca7"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="4938.5" y="337.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s376_akt1_akt1_sa244" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: ribosomal protein S6 kinase 90kDa polypeptide 1 "ribosomal protein S6 kinase 90kD polypeptide 1" HUGO:RPS6KA1 HGNC:10430 ENTREZ:6195 UNIPROT:Q15418 ribosomal protein S6 kinase 90kDa polypeptide 2 "ribosomal protein S6 kinase 90kD polypeptide 2" HUGO:RPS6KA2 HGNC:10431 ENTREZ:6196 UNIPROT:Q15349 ribosomal protein S6 kinase 90kDa polypeptide 3 CLS "Coffin-Lowry syndrome" "mental retardation X-linked 19" MRX19 "ribosomal protein S6 kinase 90kD polypeptide 3" HUGO:RPS6KA3 HGNC:10432 ENTREZ:6197 UNIPROT:P51812 ribosomal protein S6 kinase 90kDa polypeptide 6 "ribosomal protein S6 kinase 90kD polypeptide 6" HUGO:RPS6KA6 HGNC:10435 ENTREZ:27330 UNIPROT:Q9UK32 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RSK2 is a well known ERK substrate in the cytoplasm. RSKs are exclusively activated by ERK. Activated RSK can be found in both nuclear and cytoplasmic compartments. PMID:15239952 PMID:15187187 References_end Identifiers_begin: ribosomal protein S6 kinase 90kDa polypeptide 1 "ribosomal protein S6 kinase 90kD polypeptide 1" HUGO:RPS6KA1 HGNC:10430 ENTREZ:6195 UNIPROT:Q15418 GENECARDS:RPS6KA1 REACTOME:57795 KEGG:6195 ATLASONC:RPS6KA1ID43477ch1p36 WIKI:RPS6KA1 ribosomal protein S6 kinase 90kDa polypeptide 2 "ribosomal protein S6 kinase 90kD polypeptide 2" HUGO:RPS6KA2 HGNC:10431 ENTREZ:6196 UNIPROT:Q15349 GENECARDS:RPS6KA2 REACTOME:57797 KEGG:6196 ATLASONC:GC_RPS6KA2 WIKI:RPS6KA2 ribosomal protein S6 kinase 90kDa polypeptide 3 CLS "Coffin-Lowry syndrome" "mental retardation X-linked 19" MRX19 "ribosomal protein S6 kinase 90kD polypeptide 3" HUGO:RPS6KA3 HGNC:10432 ENTREZ:6197 UNIPROT:P51812 GENECARDS:RPS6KA3 REACTOME:57799 KEGG:6197 ATLASONC:GC_RPS6KA3 WIKI:RPS6KA3 ribosomal protein S6 kinase 90kDa polypeptide 6 "ribosomal protein S6 kinase 90kD polypeptide 6" HUGO:RPS6KA6 HGNC:10435 ENTREZ:27330 UNIPROT:Q9UK32 GENECARDS:RPS6KA6 REACTOME:57801 KEGG:27330 ATLASONC:GC_RPS6KA6 WIKI:RPS6KA6 ribosomal protein S6 kinase 90kDa polypeptide 4 HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 GENECARDS:RPS6KA4 REACTOME:93591 KEGG:8986 ATLASONC:GC_RPS6KA4 WIKI:RPS6KA4 HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 GENECARDS:RPS6KA4 REACTOME:93591 KEGG:8986 ATLASONC:GC_RPS6KA4 WIKI:RPS6KA4 HUGO:PIM1 HGNC:8986 ENTREZ:5292 UNIPROT:P11309 GENECARDS:PIM1 KEGG:9361 ATLASONC:PIM1ID261 WIKI:PIM1 ribosomal protein S6 kinase, 90kDa, polypeptide 5 HUGO:RPS6KA5 HGNC:10434 ENTREZ:9252 UNIPROT:O75582 GENECARDS:RPS6KA5 REACTOME:93593 KEGG:9252 ATLASONC:GC_RPS6KA5 WIKI:RPS6KA5 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RSK2 is a well known ERK substrate in the cytoplasm. RSKs are exclusively activated by ERK. Activated RSK can be found in both nuclear and cytoplasmic compartments. PMID:15239952 PMID:15187187 PMID:16286006 PMID:21233202 References_end</body> </html> Identifiers_begin: ribosomal protein S6 kinase 90kDa polypeptide 1 "ribosomal protein S6 kinase 90kD polypeptide 1" HUGO:RPS6KA1 HGNC:10430 ENTREZ:6195 UNIPROT:Q15418 GENECARDS:RPS6KA1 REACTOME:57795 KEGG:6195 ATLASONC:RPS6KA1ID43477ch1p36 WIKI:RPS6KA1 ribosomal protein S6 kinase 90kDa polypeptide 2 "ribosomal protein S6 kinase 90kD polypeptide 2" HUGO:RPS6KA2 HGNC:10431 ENTREZ:6196 UNIPROT:Q15349 GENECARDS:RPS6KA2 REACTOME:57797 KEGG:6196 ATLASONC:GC_RPS6KA2 WIKI:RPS6KA2 ribosomal protein S6 kinase 90kDa polypeptide 3 CLS "Coffin-Lowry syndrome" "mental retardation X-linked 19" MRX19 "ribosomal protein S6 kinase 90kD polypeptide 3" HUGO:RPS6KA3 HGNC:10432 ENTREZ:6197 UNIPROT:P51812 GENECARDS:RPS6KA3 REACTOME:57799 KEGG:6197 ATLASONC:GC_RPS6KA3 WIKI:RPS6KA3 ribosomal protein S6 kinase 90kDa polypeptide 6 "ribosomal protein S6 kinase 90kD polypeptide 6" HUGO:RPS6KA6 HGNC:10435 ENTREZ:27330 UNIPROT:Q9UK32 GENECARDS:RPS6KA6 REACTOME:57801 KEGG:27330 ATLASONC:GC_RPS6KA6 WIKI:RPS6KA6 ribosomal protein S6 kinase 90kDa polypeptide 4 HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 GENECARDS:RPS6KA4 REACTOME:93591 KEGG:8986 ATLASONC:GC_RPS6KA4 WIKI:RPS6KA4 HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 GENECARDS:RPS6KA4 REACTOME:93591 KEGG:8986 ATLASONC:GC_RPS6KA4 WIKI:RPS6KA4 HUGO:PIM1 HGNC:8986 ENTREZ:5292 UNIPROT:P11309 GENECARDS:PIM1 KEGG:9361 ATLASONC:PIM1ID261 WIKI:PIM1 ribosomal protein S6 kinase, 90kDa, polypeptide 5 HUGO:RPS6KA5 HGNC:10434 ENTREZ:9252 UNIPROT:O75582 GENECARDS:RPS6KA5 REACTOME:93593 KEGG:9252 ATLASONC:GC_RPS6KA5 WIKI:RPS6KA5 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RSK2 is a well known ERK substrate in the cytoplasm. RSKs are exclusively activated by ERK. Activated RSK can be found in both nuclear and cytoplasmic compartments. PMID:15239952 PMID:15187187 PMID:16286006 PMID:21233202 References_end</body> </html> </notes> <label text="RSK*"/> <bbox w="80.0" h="40.0" x="5066.0" y="1522.0"/> <glyph class="state variable" id="_86efc175-364c-4504-8c38-f16f3d38c081"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5061.0" y="1537.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s714_akt1_akt1_sa471" compartmentRef="akt1_akt1_c5_akt1_akt1_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re177:(MAP:survival) PMID:20709625 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c somatic HUGO:CYCS HGNC:19986 ENTREZ:54205 UNIPROT:P99999 GENECARDS:CYCS REACTOME:53260 KEGG:54205 ATLASONC:GC_CYCS WIKI:CYCS Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19788417 PMID:16977332 References_end</body> </html> </notes> <label text="Cytochrome_C*"/> <bbox w="80.0" h="40.0" x="6423.5" y="1060.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s715_akt1_akt1_sa472" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re177:(MAP:survival) PMID:20709625 s_akt1_re178(MAP:survival): PMID:19788417 PMID:16977332 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cytochrome c somatic HUGO:CYCS HGNC:19986 ENTREZ:54205 UNIPROT:P99999 GENECARDS:CYCS REACTOME:53260 KEGG:54205 ATLASONC:GC_CYCS WIKI:CYCS Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19788417 PMID:16977332 References_end</body> </html> </notes> <label text="Cytochrome_C*"/> <bbox w="80.0" h="40.0" x="6020.5" y="1038.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s716_akt1_akt1_sa473" compartmentRef="akt1_akt1_c5_akt1_akt1_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re177:(MAP:survival) PMID:20709625 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 GENECARDS:BAX REACTOME:50715 KEGG:581 ATLASONC:BAXID128ch19q13 WIKI:BAX Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20709625 References_end Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 GENECARDS:BAX REACTOME:50715 KEGG:581 ATLASONC:BAXID128ch19q13 WIKI:BAX Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20709625 References_end</body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="6638.0" y="1071.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s722_akt1_akt1_sa478" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re136(MAP:survival): PMID:10514377 PMID:17635922 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Cas-Br-M (murine) ecotropic retroviral transforming sequence HUGO:CBL HGNC:1541 ENTREZ:867 UNIPROT:P22681 GENECARDS:CBL REACTOME:51488 KEGG:867 ATLASONC:CBLID171 WIKI:CBL Cas-Br-M (murine) ecotropic retroviral transforming sequence b HUGO:CBLB HGNC:1542 ENTREZ:868 UNIPROT:Q13191 GENECARDS:CBLB REACTOME:405572 KEGG:326625 ATLASONC:CBLbID193 WIKI:CBLB Cas-Br-M (murine) ecotropic retroviral transforming sequence c HUGO:CBLC HGNC:15961 ENTREZ:23624 UNIPROT:Q9ULV8 GENECARDS:CBLC KEGG:23624 ATLASONC:CBLcID194 WIKI:CBLC Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17635922 PMID:10514377 References_end</body> </html> </notes> <label text="CBL*"/> <bbox w="80.0" h="40.0" x="6089.0" y="568.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s723_akt1_akt1_sa479" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re136(MAP:survival): PMID:10514377 PMID:17635922 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog yeast) HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog yeast) HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog yeast) HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17635922 PMID:10514377 References_end</body> </html> </notes> <label text="UBC4*"/> <bbox w="80.0" h="40.0" x="6091.0" y="619.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s741_akt1_akt1_sa305" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re96(MAP:survival): PMID:18570873 PMID:18636226 p27 is phosphorylated by Akt RSK1 and RSK2 in early G1 phase s_akt1_re97:(MAP:survival) PMID:19887899 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27 Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="p27KIP1*"/> <bbox w="80.0" h="40.0" x="5556.5" y="1061.6138"/> <glyph class="state variable" id="_a1b6c053-cb47-4929-9a4d-ee9cfca80c44"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5591.5" y="1056.6138"/> </glyph> <glyph class="state variable" id="_179b6dd8-887a-4647-8863-ba525e9bb18c"> <state value="" variable="S157"/> <bbox w="30.0" h="10.0" x="5621.5" y="1056.6138"/> </glyph> <glyph class="state variable" id="_82194f0e-7d12-4926-9a45-088a7cec1d26"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5591.5" y="1096.6138"/> </glyph> <glyph class="state variable" id="_529a604a-3670-4e34-aa1e-5531bf22d350"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5574.9316" y="1056.6138"/> </glyph> <glyph class="state variable" id="_a3b987a5-3f04-4a2c-bf0f-4340b349b83c"> <state value="P" variable="S10"/> <bbox w="30.0" h="10.0" x="5541.5" y="1059.016"/> </glyph> <glyph class="state variable" id="_573f54f4-1328-4375-9c49-9d35222c72d0"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="5620.882" y="1096.6138"/> </glyph> <glyph class="state variable" id="_c6b52973-080e-40d1-b527-06e3d26c2c4c"> <state value="P" variable="T157"/> <bbox w="35.0" h="10.0" x="5615.582" y="1056.6138"/> </glyph> <glyph class="state variable" id="_129713f6-2239-4758-a5d5-fdca6b7ad5ea"> <state value="P" variable="T198"/> <bbox w="35.0" h="10.0" x="5539.0" y="1096.336"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s747_akt1_akt1_sa496" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re184:(MAP:survival) PMID:18787170 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mechanistic target of rapamycin (serine/threonine kinase) HUGO:MTOR HGNC:3942 ENTREZ:2475 UNIPROT:P42345 GENECARDS:MTOR REACTOME:54978 KEGG:2475 ATLASONC:FRAP1ID40639ch1p36 WIKI:MTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19568798 PMID:17680028 PMID:21157483 References_end</body> </html> </notes> <label text="MTOR"/> <bbox w="80.0" h="40.0" x="5416.75" y="1626.1561"/> <glyph class="state variable" id="_faa79397-6328-4e22-829f-58496f03db3c"> <state value="" variable="S1261"/> <bbox w="35.0" h="10.0" x="5402.7847" y="1621.1561"/> </glyph> <glyph class="state variable" id="_99864420-0c76-4fe8-a1e2-a13d90c76856"> <state value="" variable="T2446"/> <bbox w="35.0" h="10.0" x="5475.832" y="1621.1561"/> </glyph> <glyph class="state variable" id="_938980d0-2da0-4b6e-b651-12227b1864a8"> <state value="" variable="S2448"/> <bbox w="35.0" h="10.0" x="5478.632" y="1661.1561"/> </glyph> <glyph class="state variable" id="_02b432d9-ae4b-4299-9a0d-57f5c453fa51"> <state value="" variable="S2481"/> <bbox w="35.0" h="10.0" x="5399.25" y="1660.1046"/> </glyph> <glyph class="state variable" id="_2bea5988-cc92-471b-b8b6-e4c9fdabf116"> <state value="Ub" variable="Y631"/> <bbox w="40.0" h="10.0" x="5396.75" y="1641.1561"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s751_akt1_akt1_sa499" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re186:(MAP:survival) PMID:11756412 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 GENECARDS:CDKN1A REACTOME:87048 KEGG:1026 ATLASONC:CDKN1AID139 WIKI:CDKN1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:P21CIP MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19440234 PMID:12851486 References_end</body> </html> </notes> <label text="p21CIP1*"/> <bbox w="80.0" h="40.0" x="5270.0" y="2390.0"/> <glyph class="state variable" id="_add3d109-b389-4a89-87fa-3594a915b6ec"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5265.0" y="2425.0"/> </glyph> <glyph class="state variable" id="_908f6bae-d4f3-44bc-8b7e-40c0cdb20516"> <state value="" variable="T145"/> <bbox w="30.0" h="10.0" x="5255.4927" y="2385.0"/> </glyph> <glyph class="state variable" id="_9e2b4144-3757-4ad4-8068-6d0a9a654ba8"> <state value="" variable="T146"/> <bbox w="30.0" h="10.0" x="5295.0317" y="2385.0"/> </glyph> <glyph class="state variable" id="_dc869e5a-4356-49e7-a971-870934e92b97"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5345.0" y="2405.4016"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s753_akt1_akt1_sa500" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re186:(MAP:survival) PMID:11756412 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 GENECARDS:CDKN1A REACTOME:87048 KEGG:1026 ATLASONC:CDKN1AID139 WIKI:CDKN1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:P21CIP MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19440234 PMID:12851486 References_end</body> </html> </notes> <label text="p21CIP1*"/> <bbox w="80.0" h="40.0" x="5415.5" y="2390.0"/> <glyph class="state variable" id="_05728711-d1f7-43b9-93ce-dca20afeda06"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5410.5" y="2425.0"/> </glyph> <glyph class="state variable" id="_f64b15e5-7a51-46d8-b213-83079afbb6b2"> <state value="P" variable="T145"/> <bbox w="35.0" h="10.0" x="5398.4927" y="2385.0"/> </glyph> <glyph class="state variable" id="_b9d4b150-b56b-4d4a-9436-dcefc7af5259"> <state value="" variable="T146"/> <bbox w="30.0" h="10.0" x="5440.5317" y="2385.0"/> </glyph> <glyph class="state variable" id="_dc68d507-cea5-4fe5-b2d1-6bdacd1f7c6a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5490.5" y="2405.4016"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s754_akt1_akt1_sa501" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re187:(MAP:survival) PMID:9765224 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: CASPASE3 cleaves KSR1 in apoptotic cells. Thus MEK is sequestered in the cytosol and its interaction with Raf and ERK is prevented. PMID:17613518 References_end Identifiers_begin: HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 GENECARDS:CASP3 REACTOME:57022 KEGG:836 ATLASONC:GC_CASP3 WIKI:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 caspase 3 apoptosis-related cysteine peptidase Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: CASPASE3 cleaves KSR1 in apoptotic cells. Thus MEK is sequestered in the cytosol and its interaction with Raf and ERK is prevented. PMID:17613518 PMID:9765224 References_end</body> </html> </notes> <label text="Caspase3*"/> <clone/> <bbox w="80.0" h="40.0" x="5619.0" y="2197.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s754_akt1_akt1_sa502" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re187:(MAP:survival) PMID:9765224 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: CASPASE3 cleaves KSR1 in apoptotic cells. Thus MEK is sequestered in the cytosol and its interaction with Raf and ERK is prevented. PMID:17613518 References_end Identifiers_begin: HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 GENECARDS:CASP3 REACTOME:57022 KEGG:836 ATLASONC:GC_CASP3 WIKI:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 caspase 3 apoptosis-related cysteine peptidase Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: CASPASE3 cleaves KSR1 in apoptotic cells. Thus MEK is sequestered in the cytosol and its interaction with Raf and ERK is prevented. PMID:17613518 PMID:9765224 References_end</body> </html> </notes> <label text="Caspase3*"/> <clone/> <bbox w="80.0" h="40.0" x="5619.0" y="2077.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s760_akt1_akt1_sa505" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re188:(MAP:survival) PMID:11756412 s_akt1_re189:(MAP:survival) PMID:19440234 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 GENECARDS:CDKN1A REACTOME:87048 KEGG:1026 ATLASONC:CDKN1AID139 WIKI:CDKN1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:P21CIP MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19440234 PMID:12851486 References_end</body> </html> </notes> <label text="p21CIP1*"/> <bbox w="80.0" h="40.0" x="5415.5" y="2324.0"/> <glyph class="state variable" id="_bd7e000f-2ad0-46f4-a6ff-741b12cfc516"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5410.5" y="2359.0"/> </glyph> <glyph class="state variable" id="_9bdd918e-068f-4b3e-bdd6-803402d70049"> <state value="P" variable="T145"/> <bbox w="35.0" h="10.0" x="5398.4927" y="2319.0"/> </glyph> <glyph class="state variable" id="_89e50d51-e3d5-454c-b122-06dc6b56ab14"> <state value="P" variable="T146"/> <bbox w="35.0" h="10.0" x="5438.0317" y="2319.0"/> </glyph> <glyph class="state variable" id="_c71f06bd-a9e1-455d-910d-721d29537298"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5490.5" y="2339.4016"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s761_akt1_akt1_sa506" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re187:(MAP:survival) PMID:9765224 s_wnc4_re39(MAP:survival): Positive modulaion PMID:15755874, PMID:23308069 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 8 apoptosis-related cysteine peptidase HUGO:CASP8 HGNC:1509 ENTREZ:841 UNIPROT:Q14790 GENECARDS:CASP8 REACTOME:57032 KEGG:841 ATLASONC:GC_CASP8 WIKI:CASP8 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:9765224 References_end Identifiers_begin: caspase 8 apoptosis-related cysteine peptidase HUGO:CASP8 HGNC:1509 ENTREZ:841 UNIPROT:Q14790 GENECARDS:CASP8 REACTOME:57032 KEGG:841 ATLASONC:GC_CASP8 WIKI:CASP8 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:9765224 References_end</body> </html> </notes> <label text="Caspase8*"/> <bbox w="80.0" h="40.0" x="5522.0" y="2136.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s765_akt1_akt1_sa507" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re193:(MAP:survival) PMID:20932932 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ribosomal protein S6 kinase 70kDa polypeptide 2 HUGO:RPS6KB2 HGNC:10437 ENTREZ:6199 UNIPROT:Q9UBS0 GENECARDS:RPS6KB2 REACTOME:57805 KEGG:6199 ATLASONC:GC_RPS6KB2 WIKI:RPS6KB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20932932 PMID:20647036 References_end Identifiers_begin: ribosomal protein S6 kinase 70kDa polypeptide 2 HUGO:RPS6KB2 HGNC:10437 ENTREZ:6199 UNIPROT:Q9UBS0 GENECARDS:RPS6KB2 REACTOME:57805 KEGG:6199 ATLASONC:GC_RPS6KB2 WIKI:RPS6KB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20932932 PMID:20647036 References_end</body> </html> </notes> <label text="p70β*"/> <bbox w="80.0" h="40.0" x="4425.0" y="2446.0"/> <glyph class="state variable" id="_c31e03fa-9998-4196-8bcb-40fb18ded0fb"> <state value="" variable="T388"/> <bbox w="30.0" h="10.0" x="4489.382" y="2481.0"/> </glyph> <glyph class="state variable" id="_e4326dfa-1787-4189-b2c0-30112da44817"> <state value="" variable="T228"/> <bbox w="30.0" h="10.0" x="4410.4927" y="2441.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s766_akt1_akt1_sa508" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re193:(MAP:survival) PMID:20932932 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ribosomal protein S6 kinase 70kDa polypeptide 2 HUGO:RPS6KB2 HGNC:10437 ENTREZ:6199 UNIPROT:Q9UBS0 GENECARDS:RPS6KB2 REACTOME:57805 KEGG:6199 ATLASONC:GC_RPS6KB2 WIKI:RPS6KB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20932932 PMID:20647036 References_end Identifiers_begin: ribosomal protein S6 kinase 70kDa polypeptide 2 HUGO:RPS6KB2 HGNC:10437 ENTREZ:6199 UNIPROT:Q9UBS0 GENECARDS:RPS6KB2 REACTOME:57805 KEGG:6199 ATLASONC:GC_RPS6KB2 WIKI:RPS6KB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20932932 PMID:20647036 References_end</body> </html> </notes> <label text="p70β*"/> <bbox w="80.0" h="40.0" x="4589.5" y="2446.0"/> <glyph class="state variable" id="_138606c2-7fbc-4f35-be68-7713a98f91d1"> <state value="P" variable="T388"/> <bbox w="35.0" h="10.0" x="4651.382" y="2481.0"/> </glyph> <glyph class="state variable" id="_f948bb65-c922-4625-9d2b-980c03f5dc12"> <state value="" variable="T228"/> <bbox w="30.0" h="10.0" x="4574.9927" y="2441.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s767_akt1_akt1_sa509" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re194:(MAP:survival) PMID:20932932 s_akt1_re71(MAP:survival): PMID:21233202 PMID:12713446 s_akt1_re198:(MAP:survival) PMID:20832730 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ribosomal protein S6 kinase 70kDa polypeptide 2 HUGO:RPS6KB2 HGNC:10437 ENTREZ:6199 UNIPROT:Q9UBS0 GENECARDS:RPS6KB2 REACTOME:57805 KEGG:6199 ATLASONC:GC_RPS6KB2 WIKI:RPS6KB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20932932 PMID:20647036 References_end Identifiers_begin: ribosomal protein S6 kinase 70kDa polypeptide 2 HUGO:RPS6KB2 HGNC:10437 ENTREZ:6199 UNIPROT:Q9UBS0 GENECARDS:RPS6KB2 REACTOME:57805 KEGG:6199 ATLASONC:GC_RPS6KB2 WIKI:RPS6KB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20932932 PMID:20647036 References_end</body> </html> </notes> <label text="p70β*"/> <bbox w="80.0" h="40.0" x="4763.5" y="2446.0"/> <glyph class="state variable" id="_3b5dec69-a1e7-4e5b-a189-d2e83a5fa6b2"> <state value="P" variable="T388"/> <bbox w="35.0" h="10.0" x="4825.382" y="2481.0"/> </glyph> <glyph class="state variable" id="_1f60ed09-71f6-4979-942f-d4346a1e3146"> <state value="P" variable="T228"/> <bbox w="35.0" h="10.0" x="4746.4927" y="2441.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s785_akt1_akt1_sa517" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re122:(MAP:survival) PMID:12514131 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <clone/> <bbox w="80.0" h="40.0" x="5582.0" y="1760.0"/> <glyph class="state variable" id="_6acb3d4e-24d0-48e3-85bf-69f4b86ccb9e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5577.0" y="1775.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s785_akt1_akt1_sa532" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re122:(MAP:survival) PMID:12514131 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <clone/> <bbox w="80.0" h="40.0" x="5874.0" y="1138.0"/> <glyph class="state variable" id="_2e7aa66a-60d1-485a-9d8b-a0a5f13ae641"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5869.0" y="1153.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s817_akt1_akt1_sa536" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re196:(MAP:survival) PMID:20832730 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: serum/glucocorticoid regulated kinase 1 HUGO:SGK1 HGNC:10810 ENTREZ:6446 UNIPROT:O00141 GENECARDS:SGK1 REACTOME:64398 KEGG:6446 ATLASONC:GC_SGK1 WIKI:SGK1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19584721 PMID:20338997 PMID:18570873 PMID:18925875 References_end</body> </html> </notes> <label text="SGK1"/> <bbox w="80.0" h="40.0" x="4484.25" y="902.0"/> <glyph class="state variable" id="_1654a6ba-f272-4067-8f72-b4995ede8e67"> <state value="" variable="T256"/> <bbox w="30.0" h="10.0" x="4472.7847" y="897.0"/> </glyph> <glyph class="state variable" id="_0c3e479a-a9e9-470f-b0c8-c97b74188f3e"> <state value="" variable="S442"/> <bbox w="30.0" h="10.0" x="4549.25" y="933.2789"/> </glyph> <glyph class="state variable" id="_b2782b49-a46b-405f-97ef-de5b7fb911c7"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="4474.25" y="937.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s826_akt1_akt1_sa540" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re200:(MAP:survival) PMID:20832730 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: RPTOR independent companion of MTOR complex 2 HUGO:RICTOR HGNC:28611 ENTREZ:253260 UNIPROT:Q6R327 GENECARDS:RICTOR REACTOME:245693 KEGG:253260 ATLASONC:GC_RICTOR WIKI:RICTOR Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19143635 References_end</body> </html> </notes> <label text="RICTOR"/> <bbox w="80.0" h="40.0" x="4851.25" y="806.5"/> <glyph class="state variable" id="_34ee4d2e-6fb1-40db-a4ed-1fda54a86c31"> <state value="P" variable="T1135"/> <bbox w="40.0" h="10.0" x="4850.811" y="841.5"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s827_akt1_akt1_sa541" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> </notes> <label text="CUL1"/> <bbox w="80.0" h="40.0" x="4960.5" y="806.5"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s828_akt1_akt1_sa542" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> </notes> <label text="RBX1"/> <bbox w="80.0" h="40.0" x="5064.5" y="806.5"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s832_akt1_akt1_sa545" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re201:(MAP:survival) PMID:19225151 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Unc-51-like kinase 1 HUGO:ULK1 HGNC:12558 ENTREZ:8408 UNIPROT:O75385 GENECARDS:ULK1 KEGG:8408 ATLASONC:GC_ULK1 WIKI:ULK1 Unc-51-like kinase 2 HUGO:ULK2 HGNC:13480 ENTREZ:9706 UNIPROT:Q8IYT8 GENECARDS:ULK2 KEGG:9706 ATLASONC:GC_ULK2 WIKI:ULK2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20056399 References_end</body> </html> </notes> <label text="ULK*"/> <bbox w="80.0" h="40.0" x="6382.0" y="2275.0"/> <glyph class="state variable" id="_eef31044-db38-4676-9ce5-af730ca923a6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6457.0" y="2270.0"/> </glyph> <glyph class="state variable" id="_20c7c620-bfb2-4bc3-a159-834cc0571c89"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6377.0" y="2270.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s833_akt1_akt1_sa546" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re201:(MAP:survival) PMID:19225151 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATG13 autophagy related homologue 13 HUGO:ATG13 HGNC:29091 ENTREZ:9776 UNIPROT:O75143 GENECARDS:ATG13 KEGG:9776 WIKI:ATG13 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19941614 References_end</body> </html> </notes> <label text="ATG13"/> <bbox w="80.0" h="40.0" x="6480.5" y="2275.0"/> <glyph class="state variable" id="_3c26c418-5354-4181-8658-131dfbb06719"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6555.5" y="2270.0"/> </glyph> <glyph class="state variable" id="_d5134816-e883-47a3-9a6b-210e29454929"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6475.5" y="2270.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt1_s834_akt1_akt1_sa547" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re201:(MAP:survival) PMID:19225151 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: RB1-inducible coiled-coil 1 HUGO:RB1CC1 HGNC:15574 ENTREZ:9821 UNIPROT:Q8TDY2 GENECARDS:RB1CC1 KEGG:9821 ATLASONC:GC_RB1CC1 WIKI:RB1CC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18036779 References_end</body> </html> </notes> <label text="FIP200*"/> <bbox w="80.0" h="40.0" x="6579.0" y="2275.0"/> <glyph class="state variable" id="_3a462965-f45c-48c1-a009-330523f89fa3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6574.0" y="2270.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt1_s486_akt1_akt1_sa326" compartmentRef="akt1_akt1_c2_akt1_akt1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re1:(MAP:survival) PMID:10783894 PMID:20673124 PMID:11094066 PMID:11994454 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27 Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="p27KIP1*"/> <bbox w="90.0" h="25.0" x="5115.0" y="1264.5"/> <glyph class="unit of information" id="_b3675ae1-d2c6-4a51-886e-72880c011ba3"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5150.0" y="1259.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt1_s626_akt1_akt1_sa427" compartmentRef="akt1_akt1_c2_akt1_akt1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re163:(MAP:survival) PMID:21177869 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PH domain and leucine rich repeat protein phosphatase 1 HUGO:PHLPP1 HGNC:20610 ENTREZ:23239 UNIPROT:O60346 GENECARDS:PHLPP1 REACTOME:199433 KEGG:23239 ATLASONC:PHLPP1ID44544ch18q21 WIKI:PHLPP1 PH domain and leucine rich repeat protein phosphatase 2 HUGO:PHLPP2 HGNC:29149 ENTREZ:23035 UNIPROT:Q6ZVD8 GENECARDS:PHLPP2 REACTOME:242675 KEGG:23035 ATLASONC:PHLPP2ID44546ch16q22 WIKI:PHLPP2 ENTREZ23035 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18511290 References_end</body> </html> </notes> <label text="PHLPP*"/> <bbox w="90.0" h="25.0" x="5044.0" y="1426.5"/> <glyph class="unit of information" id="_5c7f31d1-0018-4b24-9a9f-d387911a21ab"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5079.0" y="1421.5"/> </glyph> </glyph> <glyph class="simple chemical" id="akt1_s_akt1_s3_akt1_akt1_sa3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re11(MAP:survival): PMID:15584861 PMID:10648629 References_end</body> </html> </notes> <label text="GF"/> <clone/> <bbox w="70.0" h="25.0" x="4512.0" y="41.5"/> </glyph> <glyph class="simple chemical" id="akt1_s_akt1_s3_akt1_akt1_sa47"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re11(MAP:survival): PMID:15584861 PMID:10648629 References_end</body> </html> </notes> <label text="GF"/> <clone/> <bbox w="70.0" h="25.0" x="6425.5" y="57.0"/> </glyph> <glyph class="simple chemical" id="akt1_s_akt1_s22_akt1_akt1_sa13" compartmentRef="akt1_akt1_c7_akt1_akt1_ca7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: phosphatidylinositol-3,4,5-triphosphate CAS:N/A PUBCHEM:8260 CHEBI:16618 KEGGCOMPOUND:C05981 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: s_akt1_re3(MAP:survival): PMID:15534002 PMID:9779982 PMID:14585353 s_akt1_re4(MAP:survival): PMID:12040186 PMID:16288286 s_akt1_re7(MAP:survival): PMID:18802401 PMID:17680028 s_akt1_re11(MAP:survival): PMID:15584861 PMID:10648629 s_akt1_re115(MAP:survival): PMID:12791379 PMID:10582334 References_end</body> </html> </notes> <label text="PI3,4,5-P3"/> <bbox w="70.0" h="25.0" x="5418.0" y="148.5"/> </glyph> <glyph class="simple chemical" id="akt1_s_akt1_s502_akt1_akt1_sa338" compartmentRef="akt1_akt1_c7_akt1_akt1_ca7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re115(MAP:survival): PMID:12791379 PMID:10582334 References_end</body> </html> </notes> <label text="PI3,4-P2"/> <bbox w="70.0" h="25.0" x="5571.0" y="148.5"/> </glyph> <glyph class="simple chemical" id="akt1_s_akt1_s721_akt1_akt1_sa477" compartmentRef="akt1_akt1_c1_akt1_akt1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re178(MAP:survival): PMID:19788417 PMID:16977332 References_end</body> </html> </notes> <label text="dATP/ATP"/> <bbox w="70.0" h="25.0" x="5978.5" y="845.0"/> </glyph> <glyph class="simple chemical" id="akt1_s_akt1_s21_akt1_akt1_sa12" compartmentRef="akt1_akt1_c7_akt1_akt1_ca7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate CAS:N/A PUBCHEM:7726, CHEBI:18348, KEGGCOMPOUND:C04637 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: s_akt1_re4(MAP:survival): PMID:12040186 PMID:16288286 s_akt1_re3(MAP:survival): PMID:15534002 PMID:9779982 PMID:14585353 References_end</body> </html> </notes> <label text="PtdIns(4,5)-P2"/> <bbox w="70.0" h="25.0" x="5187.0" y="148.5"/> </glyph> <glyph class="unspecified entity" id="akt1_s_akt1_s204_akt1_akt1_sa154" compartmentRef="akt1_akt1_c3_akt1_akt1_ca3"> <label text="Unknown"/> <bbox w="70.0" h="25.0" x="6375.0" y="1413.5"/> </glyph> <glyph class="unspecified entity" id="akt1_s_akt1_s251_akt1_akt1_sa177" compartmentRef="akt1_akt1_c4_akt1_akt1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt1_re56(MAP:survival): PMID:19864431 PMID:12150925 PMID:15755954 References_end</body> </html> </notes> <label text="Unknown kinase"/> <bbox w="70.0" h="25.0" x="6745.0" y="1858.5"/> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s7_akt1_akt2_sa7" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27 Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="p27KIP1*"/> <bbox w="90.0" h="25.0" x="5259.0" y="3025.5"/> <glyph class="unit of information" id="_840c7ab1-ab35-4232-97af-34f399b06f38"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5294.0" y="3020.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s12_akt1_akt2_sa13" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re4:(MAP:survival) PMID:20673124 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 GENECARDS:BCL2L11 REACTOME:401534 KEGG:10018 ATLASONC:BCL2L11ID772ch2q13 WIKI:BCL2L11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19934277 PMID:20673124 References_end Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 GENECARDS:BCL2L11 REACTOME:401534 KEGG:10018 ATLASONC:BCL2L11ID772ch2q13 WIKI:BCL2L11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19934277 PMID:20673124 References_end</body> </html> </notes> <label text="BCL2L11"/> <bbox w="90.0" h="25.0" x="5259.0" y="3097.5"/> <glyph class="unit of information" id="_c1527044-0b41-4212-9f20-186d39df030d"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5294.0" y="3092.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s32_akt1_akt2_sa26" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re10:(MAP:survival) PMID:20673124 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2 binding component 3 HUGO:BBC3 HGNC:17868 ENTREZ:27113 UNIPROT:Q96PG8 GENECARDS:BBC3 KEGG:27113 ATLASONC:BBC3ID759ch19q13 WIKI:BBC3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19652530 PMID:20673124 References_end Identifiers_begin: BCL2 binding component 3 HUGO:BBC3 HGNC:17868 ENTREZ:27113 UNIPROT:Q96PG8 GENECARDS:BBC3 KEGG:27113 ATLASONC:BBC3ID759ch19q13 WIKI:BBC3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19652530 PMID:20673124 References_end</body> </html> </notes> <label text="BBC3"/> <bbox w="90.0" h="25.0" x="5259.0" y="3169.5"/> <glyph class="unit of information" id="_419e24c6-6a37-45e3-88d1-d47b32d8d2a3"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5294.0" y="3164.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s34_akt1_akt2_sa28" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re11:(MAP:survival) PMID:20673124 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Fas ligand (TNF superfamily member 6) HUGO:FASLG HGNC:11936 ENTREZ:356 UNIPROT:P48023 GENECARDS:FASLG REACTOME:66213 KEGG:356 ATLASONC:GC_FASLG WIKI:FASLG Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15160330 PMID:20673124 References_end</body> </html> </notes> <label text="FASL*"/> <bbox w="90.0" h="25.0" x="5259.0" y="3240.5"/> <glyph class="unit of information" id="_164e04d1-ae96-451a-aa72-551e0e7bf253"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5294.0" y="3235.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s36_akt1_akt2_sa30" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re12:(MAP:survival) PMID:20673124 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tumor necrosis factor (ligand) superfamily member 10 HUGO:TNFSF10 HGNC:11925 ENTREZ:8743 UNIPROT:P50591 GENECARDS:TNFSF10 REACTOME:66187 KEGG:8743 ATLASONC:TNFSF10ID42632ch3q26 WIKI:TNFSF10 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20935674 PMID:20673124 References_end</body> </html> </notes> <label text="TRAIL*"/> <bbox w="90.0" h="25.0" x="5259.0" y="3310.5"/> <glyph class="unit of information" id="_f9fcd16b-ac33-4930-85a3-a52450817b14"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5294.0" y="3305.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s48_akt1_akt2_sa43" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re20:(MAP:survival) PMID:17218262 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: RAD51 homolog (S. cerevisiae) HUGO:RAD51 HGNC:9817 ENTREZ:5888 UNIPROT:Q06609 GENECARDS:RAD51 REACTOME:62638 KEGG:5888 ATLASONC:GC_RAD51 WIKI:RAD51 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18716620 PMID:20673124 References_end</body> </html> </notes> <label text="RAD51"/> <bbox w="90.0" h="25.0" x="5259.0" y="3408.5"/> <glyph class="unit of information" id="_dc656aae-082b-432c-bcca-ad3be319eeb7"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5294.0" y="3403.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s167_akt1_akt2_sa139" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re61(MAP:survival): PMID15509806 PMID20673124 s_wca3_re116(MAP:survival): PMID:22761862 Swi/SNF complex PMID:22290435 NuRD complex: b-catenin/CTBP/Hipk2/LEF1 complex PMID:17666529 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 PMID:20673124 References_end Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 PMID:20673124 References_end Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 PMID:20673124 References_end</body> </html> </notes> <label text="CyclinD*"/> <bbox w="90.0" h="25.0" x="5259.0" y="3556.5"/> <glyph class="unit of information" id="_5d9aa0aa-3397-4f22-9823-0c2554a3b7f5"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5294.0" y="3551.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s187_akt1_akt2_sa146" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Mdm2 p53 binding protein homo HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 GENECARDS:MDM2 REACTOME:95018 KEGG:4193 ATLASONC:MDM2ID115ch12q15 WIKI:MDM2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20068088 PMID:20673124 References_end</body> </html> </notes> <label text="MDM2"/> <bbox w="90.0" h="25.0" x="5257.0" y="3713.5"/> <glyph class="unit of information" id="_12a8607e-cad2-414d-8975-5df75a3c4f8b"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5292.0" y="3708.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s206_akt1_akt2_sa163" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re79(MAP:survival): PMID:17646672 PMID20673124 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: growth arrest and DNA-damage-inducible alpha HUGO:GADD45A HGNC:4095 ENTREZ:1647 UNIPROT:P24522 GENECARDS:GADD45A KEGG:1647 ATLASONC:GC_GADD45A WIKI:GADD45A growth arrest and DNA-damage-inducible beta HUGO:GADD45B HGNC:4096 ENTREZ:4616 UNIPROT:O75293 GENECARDS:GADD45B KEGG:4616 ATLASONC:GC_GADD45B WIKI:GADD45B growth arrest and DNA-damage-inducible gamma HUGO:GADD45G HGNC:4097 ENTREZ:10912 UNIPROT:O95257 GENECARDS:GADD45G KEGG:10912 ATLASONC:GC_GADD45G WIKI:GADD45G Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20025601 PMID:20673124 References_end</body> </html> </notes> <label text="GADD45*"/> <bbox w="90.0" h="25.0" x="5259.0" y="3359.5"/> <glyph class="unit of information" id="_6f604c12-52c9-492a-82c9-6ac272376acc"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5294.0" y="3354.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s215_akt1_akt2_sa171" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re86:(MAP:survival) PMID:15509806 PMID:20673124 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL6 corepressor HUGO:BCOR HGNC:20893 ENTREZ:54880 UNIPROT:Q6W2J9 GENECARDS:BCOR KEGG:54880 ATLASONC:GC_BCOR WIKI:BCOR Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15509806 PMID:20673124 References_end</body> </html> </notes> <label text="BCL6*"/> <bbox w="90.0" h="25.0" x="5257.0" y="3764.5"/> <glyph class="unit of information" id="_3e5965d1-5e3c-41f8-a2f2-c3c645b27a62"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5292.0" y="3759.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s238_akt1_akt2_sa185" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re93:(MAP:survival) PMID19244250 s_akt2_re132:(MAP:survival) PMID:19574223 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15668399 PMID:20673124 References_end</body> </html> </notes> <label text="FOXO1"/> <bbox w="90.0" h="25.0" x="5258.0" y="3813.5"/> <glyph class="unit of information" id="_8de6b08f-de58-4410-a4af-5e7ad7f55c76"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5293.0" y="3808.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s242_akt1_akt2_sa189" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re96:(MAP:survival) PMID:20673124 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 2B (p15 inhibits CDK4) HUGO:CDKN2B HGNC:1788 ENTREZ:1030 UNIPROT:P42772 GENECARDS:CDKN2B REACTOME:87041 KEGG:1030 ATLASONC:CDKN2BID187ch9p21 WIKI:CDKN2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12542976 PMID:20673124 References_end</body> </html> </notes> <label text="p15INK4B*"/> <bbox w="90.0" h="25.0" x="5258.0" y="3931.5"/> <glyph class="unit of information" id="_f54f6ef1-2b79-45eb-b529-a38e09a84e73"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5293.0" y="3926.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s244_akt1_akt2_sa191" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re97:(MAP:survival) PMID:20673124 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 2D (p19 inhibits CDK4) HUGO:CDKN2D HGNC:1790 ENTREZ:1032 UNIPROT:P55273 GENECARDS:CDKN2D REACTOME:87046 KEGG:1032 ATLASONC:GC_CDKN2D WIKI:CDKN2D Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12542976 PMID:20673124 References_end</body> </html> </notes> <label text="p19INK4D*"/> <bbox w="90.0" h="25.0" x="5258.0" y="3980.5"/> <glyph class="unit of information" id="_5317d5a5-a904-4422-831e-58d2edc4c815"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5293.0" y="3975.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s246_akt1_akt2_sa193" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polo-like kinase 1 HUGO:PLK1 HGNC:9077 ENTREZ:5347 UNIPROT:P53350 GENECARDS:PLK1 REACTOME:69858 KEGG:5347 ATLASONC:PLK1ID41747ch16p12 WIKI:PLK1 polo-like kinase 2 HUGO:PLK2 HGNC:19699 ENTREZ:10769 UNIPROT:Q9NYY3 GENECARDS:PLK2 KEGG:10769 ATLASONC:GC_PLK2 WIKI:PLK2 polo-like kinase 3 HUGO:PLK3 HGNC:2154 ENTREZ:1263 UNIPROT:Q9H4B4 GENECARDS:PLK3 KEGG:1263 ATLASONC:GC_PLK3 WIKI:PLK3 polo-like kinase 4 HUGO:PLK4 HGNC:11397 ENTREZ:10733 UNIPROT:O00444 GENECARDS:PLK4 REACTOME:152249 KEGG:10733 ATLASONC:GC_PLK4 WIKI:PLK4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20068088 PMID:20673124 References_end</body> </html> </notes> <label text="PLK1"/> <bbox w="90.0" h="25.0" x="5257.0" y="3672.5"/> <glyph class="unit of information" id="_0e4defc2-c2d1-4d78-b3cc-5c2f67199431"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5292.0" y="3667.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s248_akt1_akt2_sa195" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re99:(MAP:survival) PMID:20673124 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: TNFRSF1A-associated via death domain HUGO:TRADD HGNC:12030 ENTREZ:8717 UNIPROT:Q15628 GENECARDS:TRADD REACTOME:66377 KEGG:8717 ATLASONC:GC_TRADD WIKI:TRADD Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19893571 PMID:20673124 References_end</body> </html> </notes> <label text="TRADD"/> <bbox w="90.0" h="25.0" x="5258.0" y="4023.5"/> <glyph class="unit of information" id="_d9d274f4-732f-4a3d-bab2-faa34272119b"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5293.0" y="4018.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s252_akt1_akt2_sa199" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re101:(MAP:survival) PMID:20673124 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PTEN induced putative kinase 1 HUGO:PINK1 HGNC:14581 ENTREZ:65018 UNIPROT:Q9BXM7 GENECARDS:PINK1 KEGG:65018 ATLASONC:GC_PINK1 WIKI:PINK1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21179058 PMID:20673124 References_end</body> </html> </notes> <label text="PINK1"/> <bbox w="90.0" h="25.0" x="5258.0" y="4069.5"/> <glyph class="unit of information" id="_a994db86-39ed-4534-bcc8-0e518ad428d1"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5293.0" y="4064.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s254_akt1_akt2_sa201" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re102:(MAP:survival) PMID:20673124 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O3 HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 GENECARDS:FOXO3 REACTOME:199273 KEGG:2309 ATLASONC:AF6q21ID125 WIKI:FOXO3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20673124 PMID:16288288 PMID:17646672 References_end</body> </html> </notes> <label text="FOXO3"/> <bbox w="90.0" h="25.0" x="5258.0" y="3854.5"/> <glyph class="unit of information" id="_2240a68d-9a26-453d-9df3-4e031b6a11f5"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5293.0" y="3849.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s256_akt1_akt2_sa203" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re103(MAP:survival): PMID:20673124 PMID:18644865 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphoinositide-3-kinase catalytic alpha polypeptide HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 GENECARDS:PIK3CA REACTOME:61074 KEGG:5290 ATLASONC:PIK3CAID415ch3q26 WIKI:PIK3CA phosphoinositide-3-kinase catalytic beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase catalytic delta polypeptide HUGO:PIK3CD HGNC:8977 ENTREZ:5293 UNIPROT:O00329 GENECARDS:PIK3CD REACTOME:61078 KEGG:5293 ATLASONC:PIK3CDID46261ch1p36 WIKI:PIK3CD phosphoinositide-3-kinase catalytic gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 PMID:20673124 References_end</body> </html> </notes> <label text="p110*"/> <bbox w="90.0" h="25.0" x="5258.0" y="4114.5"/> <glyph class="unit of information" id="_cce47830-4136-4f1f-8905-d3b59dda39e6"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5293.0" y="4109.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s403_akt1_akt2_sa293" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re151:(MAP:survival) PMID:10753867 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Bcl-2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 GENECARDS:BCL2 REACTOME:50758 KEGG:596 ATLASONC:BCL2ID49 WIKI:BCL2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18097445 PMID:9735050 References_end Identifiers_begin: Bcl-2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 GENECARDS:BCL2 REACTOME:50758 KEGG:596 ATLASONC:BCL2ID49 WIKI:BCL2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18097445 PMID:9735050 References_end</body> </html> </notes> <label text="BCL2"/> <bbox w="90.0" h="25.0" x="6513.0" y="4514.5"/> <glyph class="unit of information" id="_a2a15d15-dffa-417b-afc2-9c2d5ac414f6"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="6548.0" y="4509.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s413_akt1_akt2_sa303" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re154:(MAP:survival) PMID:10454566 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: myeloid cell leukemia sequence 1 (BCL2-related) HUGO:MCL1 HGNC:6943 ENTREZ:4170 UNIPROT:Q07820 GENECARDS:MCL1 KEGG:4170 ATLASONC:GC_MCL1 WIKI:MCL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20540941 PMID:10454566 References_end</body> </html> </notes> <label text="MCL1"/> <bbox w="90.0" h="25.0" x="6513.0" y="4465.5"/> <glyph class="unit of information" id="_75d8b0f2-cf80-412c-82c1-b129959600c4"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="6548.0" y="4460.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s415_akt1_akt2_sa305" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re156:(MAP:survival) PMID:18199536 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homo Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homo Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end</body> </html> </notes> <label text="PTEN"/> <bbox w="90.0" h="25.0" x="4820.5" y="4337.5"/> <glyph class="unit of information" id="_7cd3931b-1ebe-4cf1-ac81-0abf8316c67b"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4855.5" y="4332.5"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s4_akt1_akt2_sa205" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re112:(MAP:survival) PMID:11313479 s_akt2_re113:(MAP:survival) PMID:10217147 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O4 HUGO:FOXO4 HGNC:7139 ENTREZ:4303 UNIPROT:P98177 GENECARDS:FOXO4 REACTOME:404982 KEGG:4303 ATLASONC:AFX1ID57 WIKI:FOXO4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11313479 PMID:10217147 PMID:12391153 References_end</body> </html> </notes> <label text="FOXO4"/> <bbox w="80.0" h="40.0" x="4833.5" y="3570.0"/> <glyph class="state variable" id="_ef74facc-8897-4683-ace6-f9c53df6905d"> <state value="" variable="S193"/> <bbox w="30.0" h="10.0" x="4898.5" y="3565.2148"/> </glyph> <glyph class="state variable" id="_3088df09-407d-4eeb-8db9-e6e028a8c0cc"> <state value="" variable="S258"/> <bbox w="30.0" h="10.0" x="4897.882" y="3605.0"/> </glyph> <glyph class="state variable" id="_941f5e60-aa15-42eb-bbdc-0ae305b6acba"> <state value="" variable="T28"/> <bbox w="25.0" h="10.0" x="4821.4927" y="3565.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s21_akt1_akt2_sa17" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re8:(MAP:survival) PMID:11864996 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 GENECARDS:FOXO3 REACTOME:199273 KEGG:2309 ATLASONC:AF6q21ID125 WIKI:FOXO3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16288288 PMID:17646672 References_end</body> </html> </notes> <label text="FOXO3"/> <bbox w="80.0" h="40.0" x="4822.75" y="3170.5"/> <glyph class="state variable" id="_56670dd6-dbf0-4beb-a576-336f6d0785ff"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4857.75" y="3165.5"/> </glyph> <glyph class="state variable" id="_ac01af01-012a-414c-bbe3-8a3318fd58cc"> <state value="" variable="S644"/> <bbox w="30.0" h="10.0" x="4807.75" y="3205.2224"/> </glyph> <glyph class="state variable" id="_cf557eff-7630-480e-9acf-c20537278139"> <state value="" variable="T32"/> <bbox w="25.0" h="10.0" x="4810.25" y="3166.4302"/> </glyph> <glyph class="state variable" id="_6206ba6e-a7c3-4377-ac3c-c3fb2ee78c4c"> <state value="" variable="S253"/> <bbox w="30.0" h="10.0" x="4887.75" y="3204.6306"/> </glyph> <glyph class="state variable" id="_2a61ecf6-63fc-4c1c-9e2a-87b1abb6266d"> <state value="" variable="S315"/> <bbox w="30.0" h="10.0" x="4884.332" y="3165.5"/> </glyph> <glyph class="state variable" id="_de4bd161-e389-492e-b0ca-300ce36c60c2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4817.75" y="3185.5"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s23_akt1_akt2_sa19" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <clone/> <bbox w="80.0" h="40.0" x="4439.0" y="3041.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s23_akt1_akt2_sa233" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <clone/> <bbox w="80.0" h="40.0" x="4542.5" y="4575.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s24_akt1_akt2_sa20" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re8:(MAP:survival) PMID:11864996 s_akt2_re118:(MAP:survival) PMID:14664696 s_wnc2_re86:(MAP:survival) PMID:10611249 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="4695.5" y="3170.5"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s38_akt1_akt2_sa32" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re14:(MAP:survival) PMID:18716620 s_akt2_re18(MAP:survival): PMID:17218262 PMID:17218252 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end</body> </html> </notes> <label text="PTEN"/> <bbox w="80.0" h="40.0" x="5485.0" y="3897.0"/> <glyph class="state variable" id="_5d11bd4c-3b7f-416a-8438-bafdae97b134"> <state value="" variable="S380"/> <bbox w="30.0" h="10.0" x="5520.2476" y="3892.0"/> </glyph> <glyph class="state variable" id="_0cd57402-2257-48ca-a6e5-c243cb8357a1"> <state value="" variable="S370"/> <bbox w="30.0" h="10.0" x="5549.6333" y="3892.0"/> </glyph> <glyph class="state variable" id="_2154fa98-007f-4bf2-a955-81073d5a9614"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5560.0" y="3932.0"/> </glyph> <glyph class="state variable" id="_4b4dad65-5e1d-4bad-a6e9-cea09b9892de"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5480.0" y="3932.0"/> </glyph> <glyph class="state variable" id="_83d61564-597c-4f9c-ab4c-027f982c1ad5"> <state value="" variable="K289"/> <bbox w="30.0" h="10.0" x="5510.7046" y="3932.0"/> </glyph> <glyph class="state variable" id="_c567c290-6856-411b-97e4-567bdde7f851"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5480.0" y="3892.0"/> </glyph> <glyph class="state variable" id="_27dc2a92-8d34-48fc-896b-225c25468fb2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5560.0" y="3892.0"/> </glyph> <glyph class="state variable" id="_30db8f4c-579e-4760-9178-183c7d24f9c0"> <state value="" variable="K13"/> <bbox w="25.0" h="10.0" x="5472.74" y="3932.0"/> </glyph> <glyph class="state variable" id="_3b1889c7-9492-49f2-ad67-3b4e4540fe83"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="5470.0" y="3911.9683"/> </glyph> <glyph class="state variable" id="_854fd856-9fec-45fe-9198-1b8ec62efc0c"> <state value="" variable="T366"/> <bbox w="30.0" h="10.0" x="5550.0" y="3912.0"/> </glyph> <glyph class="state variable" id="_1a187698-a7da-4bf5-889b-b87b91e37fc7"> <state value="" variable="T383"/> <bbox w="30.0" h="10.0" x="5470.0" y="3894.402"/> </glyph> <glyph class="state variable" id="_74fec8b8-db12-4bc4-acd8-0b3ff2b83a30"> <state value="" variable="T382"/> <bbox w="30.0" h="10.0" x="5498.532" y="3892.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s39_akt1_akt2_sa33" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end</body> </html> </notes> <label text="PTEN"/> <bbox w="80.0" h="40.0" x="5656.5" y="3899.0"/> <glyph class="state variable" id="_5f1dab7a-27a1-4047-bbe0-a5f70b40e68c"> <state value="" variable="S380"/> <bbox w="30.0" h="10.0" x="5691.7476" y="3894.0"/> </glyph> <glyph class="state variable" id="_ebdb1ebf-5aee-4ee1-af25-5d3a949c1fe5"> <state value="" variable="S370"/> <bbox w="30.0" h="10.0" x="5721.1333" y="3894.0"/> </glyph> <glyph class="state variable" id="_c20a37a4-a1e6-4ea3-8c37-f678ebf7acfa"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5731.5" y="3934.0"/> </glyph> <glyph class="state variable" id="_25eaf4f0-913a-4ded-9343-fd0b017e9c2d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5651.5" y="3934.0"/> </glyph> <glyph class="state variable" id="_a81c9c71-a166-48b5-8d95-ce73c9921d4f"> <state value="" variable="K289"/> <bbox w="30.0" h="10.0" x="5682.2046" y="3934.0"/> </glyph> <glyph class="state variable" id="_9ffd5615-3e19-4d0f-bfc1-99eac7f2e5e7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5651.5" y="3894.0"/> </glyph> <glyph class="state variable" id="_fd95c52e-639c-405c-8a3e-a8c45403a737"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5731.5" y="3894.0"/> </glyph> <glyph class="state variable" id="_5bc2acc4-79e4-4d6a-ae17-6d4d300a1303"> <state value="" variable="K13"/> <bbox w="25.0" h="10.0" x="5644.24" y="3934.0"/> </glyph> <glyph class="state variable" id="_d5549629-7c5b-4883-93cc-4369e3aa8a99"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="5641.5" y="3913.9683"/> </glyph> <glyph class="state variable" id="_1007af3a-41fa-447c-a439-2c000aac1d50"> <state value="" variable="T366"/> <bbox w="30.0" h="10.0" x="5721.5" y="3914.0"/> </glyph> <glyph class="state variable" id="_3e2ade69-7447-4a45-9780-bd317ec4b66d"> <state value="" variable="T383"/> <bbox w="30.0" h="10.0" x="5641.5" y="3896.402"/> </glyph> <glyph class="state variable" id="_8adaf66b-00ae-4d9e-a378-d688b2fe33d4"> <state value="" variable="T382"/> <bbox w="30.0" h="10.0" x="5670.032" y="3894.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s42_akt1_akt2_sa37" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re17:(MAP:survival) PMID:18716620 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquitin specific peptidase 7 (herpes virus-associated) HUGO:USP7 HGNC:12630 ENTREZ:7874 UNIPROT:Q93009 GENECARDS:USP7 KEGG:7874 ATLASONC:USP7ID42773ch16p13 WIKI:USP7 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18716620 References_end</body> </html> </notes> <label text="HAUSP*"/> <clone/> <bbox w="80.0" h="40.0" x="5752.0" y="3956.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s42_akt1_akt2_sa39" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re17:(MAP:survival) PMID:18716620 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquitin specific peptidase 7 (herpes virus-associated) HUGO:USP7 HGNC:12630 ENTREZ:7874 UNIPROT:Q93009 GENECARDS:USP7 KEGG:7874 ATLASONC:USP7ID42773ch16p13 WIKI:USP7 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18716620 References_end</body> </html> </notes> <label text="HAUSP*"/> <clone/> <bbox w="80.0" h="40.0" x="5752.5" y="4050.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s43_akt1_akt2_sa36" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re14:(MAP:survival) PMID:18716620 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end</body> </html> </notes> <label text="PTEN"/> <bbox w="80.0" h="40.0" x="5577.75" y="4040.0"/> <glyph class="state variable" id="_feebffcb-cf12-4fe7-8966-441217103ebc"> <state value="" variable="S380"/> <bbox w="30.0" h="10.0" x="5612.9976" y="4035.0"/> </glyph> <glyph class="state variable" id="_673e9923-3d84-49d5-8429-c8a619ab9764"> <state value="" variable="S370"/> <bbox w="30.0" h="10.0" x="5642.3833" y="4035.0"/> </glyph> <glyph class="state variable" id="_b209d664-d1ee-488f-ae6a-74b62f003a14"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5652.75" y="4075.0"/> </glyph> <glyph class="state variable" id="_71058909-7d04-44e5-8b36-14e764ee30f0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5572.75" y="4075.0"/> </glyph> <glyph class="state variable" id="_786bfdff-abd6-4351-9498-0e045b1364ab"> <state value="" variable="K289"/> <bbox w="30.0" h="10.0" x="5603.4546" y="4075.0"/> </glyph> <glyph class="state variable" id="_6d2ff605-45d5-4f13-b6fa-51ccf94853af"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5572.75" y="4035.0"/> </glyph> <glyph class="state variable" id="_25ff3852-626a-4505-9fa3-e26c3428d9b3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5652.75" y="4035.0"/> </glyph> <glyph class="state variable" id="_357ea56e-a726-41ef-b40e-cc7b287ed616"> <state value="" variable="K13"/> <bbox w="25.0" h="10.0" x="5565.49" y="4075.0"/> </glyph> <glyph class="state variable" id="_433c98b1-67d9-4e48-bbe0-410d8d35099f"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="5562.75" y="4054.9683"/> </glyph> <glyph class="state variable" id="_a06f6815-0ec2-4f71-9508-aec19623675d"> <state value="" variable="T366"/> <bbox w="30.0" h="10.0" x="5642.75" y="4055.0"/> </glyph> <glyph class="state variable" id="_78ee95b3-9db6-4959-b8b9-a07a65fcfdaf"> <state value="" variable="T383"/> <bbox w="30.0" h="10.0" x="5562.75" y="4037.402"/> </glyph> <glyph class="state variable" id="_0f23ad23-2095-4249-a091-be38a2f4550a"> <state value="" variable="T382"/> <bbox w="30.0" h="10.0" x="5591.282" y="4035.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s49_akt1_akt2_sa44" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re20:(MAP:survival) PMID:17218262 s_wca4_re4(MAP:survival): PMID:22699938 E2F1 PMID:15766563 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: E2F transcription factor 1 HUGO:E2F1 HGNC:3113 ENTREZ:1869 UNIPROT:Q01094 GENECARDS:E2F1 REACTOME:89561 KEGG:1869 ATLASONC:E2F1ID40382ch20q11 WIKI:E2F1 RBBP3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G1_CC_PHASE MAP:dnarepair / MODULE:S_CC_PHASE MAP:cellcycle / MODULE:E2F1 MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17218262 References_end Identifiers_begin: E2F transcription factor 1 HUGO:E2F1 HGNC:3113 ENTREZ:1869 UNIPROT:Q01094 GENECARDS:E2F1 REACTOME:89561 KEGG:1869 ATLASONC:E2F1ID40382ch20q11 WIKI:E2F1 RBBP3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G1_CC_PHASE MAP:dnarepair / MODULE:S_CC_PHASE MAP:cellcycle / MODULE:E2F1 MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17218262 References_end</body> </html> </notes> <label text="E2F1"/> <bbox w="80.0" h="40.0" x="5200.0" y="3502.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s51_akt1_akt2_sa46" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta HUGO:IKBKB HGNC:5960 ENTREZ:3551 UNIPROT:O14920 GENECARDS:IKBKB REACTOME:57216 KEGG:3551 ATLASONC:GC_IKBKB WIKI:IKBKB Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20300203 PMID:17693255 PMID:18716620 References_end</body> </html> </notes> <label text="IKKβ*"/> <bbox w="80.0" h="40.0" x="5445.0" y="3708.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s1_akt1_akt2_sa1" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re28(MAP:survival): PMID:16680151 PMID:20452955 PMID:19216069 s_akt2_re66:(MAP:survival) PMID15169778 s_akt2_re89:(MAP:survival) PMID:17646672 s_akt2_re113:(MAP:survival) PMID:10217147 s_akt2_re144:(MAP:survival) PMID:11463845 PMID:11756412 s_akt2_re152:(MAP:survival) PMID:9829964 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 GENECARDS:AKT2 REACTOME:49860 KEGG:208 ATLASONC:AKT2ID517ch19q13 WIKI:AKT2 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:CDH2 HGNC:1759 ENTREZ:1000 UNIPROT:P19022 GENECARDS:CDH2 REACTOME:51212 KEGG:1000 ATLASONC:GC_CDH2 WIKI:CDH2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 GENECARDS:AKT2 REACTOME:49860 KEGG:208 ATLASONC:AKT2ID517ch19q13 WIKI:AKT2 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:CDH2 HGNC:1759 ENTREZ:1000 UNIPROT:P19022 GENECARDS:CDH2 REACTOME:51212 KEGG:1000 ATLASONC:GC_CDH2 WIKI:CDH2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 GENECARDS:AKT2 REACTOME:49860 KEGG:208 ATLASONC:AKT2ID517ch19q13 WIKI:AKT2 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:CDH2 HGNC:1759 ENTREZ:1000 UNIPROT:P19022 GENECARDS:CDH2 REACTOME:51212 KEGG:1000 ATLASONC:GC_CDH2 WIKI:CDH2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end</body> </html> </notes> <label text="AKT*"/> <bbox w="80.0" h="40.0" x="4835.5" y="3099.0"/> <glyph class="state variable" id="_6ad5c7f5-3c43-4932-aaa4-eba10ee0921a"> <state value="" variable="S129"/> <bbox w="30.0" h="10.0" x="4820.5" y="3133.7224"/> </glyph> <glyph class="state variable" id="_7fd829d3-e9a5-4860-aefb-cd9695e1f24f"> <state value="P" variable="T450"/> <bbox w="35.0" h="10.0" x="4898.0" y="3094.2148"/> </glyph> <glyph class="state variable" id="_ad1f3187-6763-434f-ae55-a999c580ef00"> <state value="P" variable="S473"/> <bbox w="35.0" h="10.0" x="4897.382" y="3134.0"/> </glyph> <glyph class="state variable" id="_0c2f457d-4db7-4005-857b-fc9e9739bd37"> <state value="P" variable="T308"/> <bbox w="35.0" h="10.0" x="4818.4927" y="3094.0"/> </glyph> <glyph class="state variable" id="_7b3b23b9-5184-4ae0-ae90-cf2044961e1a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4910.5" y="3094.0"/> </glyph> <glyph class="state variable" id="_aa73b5e2-2033-472a-81f6-22bc783b8113"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4830.5" y="3114.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s67_akt1_akt2_sa60" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re28(MAP:survival): PMID:16680151 PMID:20452955 PMID:19216069 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 GENECARDS:AKT2 REACTOME:49860 KEGG:208 ATLASONC:AKT2ID517ch19q13 WIKI:AKT2 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:CDH2 HGNC:1759 ENTREZ:1000 UNIPROT:P19022 GENECARDS:CDH2 REACTOME:51212 KEGG:1000 ATLASONC:GC_CDH2 WIKI:CDH2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 GENECARDS:AKT2 REACTOME:49860 KEGG:208 ATLASONC:AKT2ID517ch19q13 WIKI:AKT2 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:CDH2 HGNC:1759 ENTREZ:1000 UNIPROT:P19022 GENECARDS:CDH2 REACTOME:51212 KEGG:1000 ATLASONC:GC_CDH2 WIKI:CDH2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 GENECARDS:AKT2 REACTOME:49860 KEGG:208 ATLASONC:AKT2ID517ch19q13 WIKI:AKT2 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:CDH2 HGNC:1759 ENTREZ:1000 UNIPROT:P19022 GENECARDS:CDH2 REACTOME:51212 KEGG:1000 ATLASONC:GC_CDH2 WIKI:CDH2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end</body> </html> </notes> <label text="AKT*"/> <bbox w="80.0" h="40.0" x="5192.5" y="2936.0"/> <glyph class="state variable" id="_f1fed706-7a81-4b23-bf98-27e08d72b926"> <state value="" variable="S129"/> <bbox w="30.0" h="10.0" x="5177.5" y="2970.7224"/> </glyph> <glyph class="state variable" id="_8e1f5783-15f3-4250-a42f-5b69569cdbb9"> <state value="P" variable="T450"/> <bbox w="35.0" h="10.0" x="5255.0" y="2931.2148"/> </glyph> <glyph class="state variable" id="_b8ac612f-2ac5-40f9-b6f6-fb41e9a0ea5c"> <state value="P" variable="S473"/> <bbox w="35.0" h="10.0" x="5254.382" y="2971.0"/> </glyph> <glyph class="state variable" id="_b554e8be-7b70-461f-88b0-ac53d2990dc3"> <state value="" variable="T308"/> <bbox w="30.0" h="10.0" x="5177.9927" y="2931.0"/> </glyph> <glyph class="state variable" id="_f97431c4-0a89-480e-97b8-94b3d11fb0ad"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5267.5" y="2931.0"/> </glyph> <glyph class="state variable" id="_70d299db-9b4b-4f63-be85-9a534f3ba280"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5187.5" y="2951.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s13_akt1_akt2_sa14" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re2:(MAP:survival) PMID:11154281 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: serum/glucocorticoid regulated kinase 1 HUGO:SGK1 HGNC:10810 ENTREZ:6446 UNIPROT:O00141 GENECARDS:SGK1 REACTOME:64398 KEGG:6446 ATLASONC:GC_SGK1 WIKI:SGK1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19584721 PMID:20338997 PMID:18570873 PMID:18925875 References_end</body> </html> </notes> <label text="SGK1"/> <bbox w="80.0" h="40.0" x="4956.5" y="3099.0"/> <glyph class="state variable" id="_521d5465-dab9-481c-994e-ccba1e5421d1"> <state value="" variable="T256"/> <bbox w="30.0" h="10.0" x="4945.0347" y="3094.0"/> </glyph> <glyph class="state variable" id="_a816b3a4-575f-4b4a-a81c-3f4bfbb94ddb"> <state value="" variable="S442"/> <bbox w="30.0" h="10.0" x="5021.5" y="3130.2788"/> </glyph> <glyph class="state variable" id="_9e6e0dac-ed68-4af7-bbb7-c1d095fa964d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4951.5" y="3134.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s77_akt1_akt2_sa71" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27 Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="p27KIP1*"/> <bbox w="80.0" h="40.0" x="5382.0" y="2656.0"/> <glyph class="state variable" id="_77976719-67b6-4332-b93a-10790c17ca94"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5417.0" y="2651.0"/> </glyph> <glyph class="state variable" id="_470085bb-cb23-44ae-84d5-82ecdfeb8c14"> <state value="" variable="S157"/> <bbox w="30.0" h="10.0" x="5447.0" y="2651.0"/> </glyph> <glyph class="state variable" id="_dba8adcf-bf74-401a-8275-2282ba3e5c59"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5417.0" y="2691.0"/> </glyph> <glyph class="state variable" id="_49685c87-8199-4245-8fd1-499018084601"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5400.4316" y="2651.0"/> </glyph> <glyph class="state variable" id="_34913c01-e57f-425a-86bd-a965f88a3f14"> <state value="" variable="S10"/> <bbox w="25.0" h="10.0" x="5369.5" y="2653.402"/> </glyph> <glyph class="state variable" id="_5a8784c3-6537-4cdc-aea7-493ed468d7f0"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="5446.382" y="2691.0"/> </glyph> <glyph class="state variable" id="_ec8587f3-68e7-49d0-ad1d-108726755e81"> <state value="" variable="T157"/> <bbox w="30.0" h="10.0" x="5443.582" y="2651.0"/> </glyph> <glyph class="state variable" id="_fb722de7-4b91-4a30-8927-275d331745c1"> <state value="" variable="T198"/> <bbox w="30.0" h="10.0" x="5367.0" y="2690.7224"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s78_akt1_akt2_sa72" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re38(MAP:survival): PMID:18636226 PMID:15147722 PMID:14536078 PMID:12459251 s_akt2_re39:(MAP:survival) PMID:15147722 PMID:18006823 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27 Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="p27KIP1*"/> <clone/> <bbox w="80.0" h="40.0" x="5560.5" y="3061.5"/> <glyph class="state variable" id="_2bfa531c-cf63-493e-a366-7f0139ed86ef"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5595.5" y="3056.5"/> </glyph> <glyph class="state variable" id="_bb7ef6ac-85eb-4fe5-aed7-9d295ff707fd"> <state value="" variable="S157"/> <bbox w="30.0" h="10.0" x="5625.5" y="3056.5"/> </glyph> <glyph class="state variable" id="_213436a1-57fc-4311-821c-f8e8a575be1e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5595.5" y="3096.5"/> </glyph> <glyph class="state variable" id="_324a1a0f-f460-4769-81ba-7c07cb0e9100"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5578.9316" y="3056.5"/> </glyph> <glyph class="state variable" id="_18a05c67-d3d0-4f3b-9c35-d7e867f905ea"> <state value="" variable="S10"/> <bbox w="25.0" h="10.0" x="5548.0" y="3058.902"/> </glyph> <glyph class="state variable" id="_10cc24e7-5143-49f8-87f6-e606aea82215"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="5624.882" y="3096.5"/> </glyph> <glyph class="state variable" id="_f6d0b232-4237-4ba7-a51d-80f8cf9164a6"> <state value="" variable="T157"/> <bbox w="30.0" h="10.0" x="5622.082" y="3056.5"/> </glyph> <glyph class="state variable" id="_968df0cc-f7b2-48d2-bf46-2df865ea1cb6"> <state value="" variable="T198"/> <bbox w="30.0" h="10.0" x="5545.5" y="3096.2224"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s78_akt1_akt2_sa86" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re38(MAP:survival): PMID:18636226 PMID:15147722 PMID:14536078 PMID:12459251 s_akt2_re39:(MAP:survival) PMID:15147722 PMID:18006823 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27 Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="p27KIP1*"/> <clone/> <bbox w="80.0" h="40.0" x="5738.0" y="3368.0"/> <glyph class="state variable" id="_bf9ef592-bc49-49b9-af72-4ed312140ecb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5773.0" y="3363.0"/> </glyph> <glyph class="state variable" id="_b939c2a3-cf40-44c6-b40e-35a82cf83cd4"> <state value="" variable="S157"/> <bbox w="30.0" h="10.0" x="5803.0" y="3363.0"/> </glyph> <glyph class="state variable" id="_52a1a497-8704-4fba-8c93-88f813bb355b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5773.0" y="3403.0"/> </glyph> <glyph class="state variable" id="_7d36d01b-f985-4962-9531-ed21f2c543b7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5756.4316" y="3363.0"/> </glyph> <glyph class="state variable" id="_03d3371d-bae3-47ed-8db2-dfd9e4dc35b6"> <state value="" variable="S10"/> <bbox w="25.0" h="10.0" x="5725.5" y="3365.402"/> </glyph> <glyph class="state variable" id="_d6760328-c7a3-4b95-9716-e0a2ef497943"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="5802.382" y="3403.0"/> </glyph> <glyph class="state variable" id="_374bd2e1-115f-4df7-b7bf-e9234e2cc0bc"> <state value="" variable="T157"/> <bbox w="30.0" h="10.0" x="5799.582" y="3363.0"/> </glyph> <glyph class="state variable" id="_c2edc48d-8775-4fb3-b2d2-8b97db1bcb4a"> <state value="" variable="T198"/> <bbox w="30.0" h="10.0" x="5723.0" y="3402.7224"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s79_akt1_akt2_sa73" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re31(MAP:survival): PMID:18636226 PMID:19887899 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27 Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="p27KIP1*"/> <bbox w="80.0" h="40.0" x="5560.5" y="2971.0"/> <glyph class="state variable" id="_f2b82e8d-e6ca-4555-80b4-181da52c6735"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5595.5" y="2966.0"/> </glyph> <glyph class="state variable" id="_86613906-ca0c-4d62-a8d5-4c492d80f470"> <state value="" variable="S157"/> <bbox w="30.0" h="10.0" x="5625.5" y="2966.0"/> </glyph> <glyph class="state variable" id="_951fc814-6088-4b31-9812-59813e882a77"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5595.5" y="3006.0"/> </glyph> <glyph class="state variable" id="_d3ad7030-5b1f-4baf-8539-c40173eed33d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5578.9316" y="2966.0"/> </glyph> <glyph class="state variable" id="_7373ff88-c41b-471c-a86a-22a052b9c570"> <state value="" variable="S10"/> <bbox w="25.0" h="10.0" x="5548.0" y="2968.402"/> </glyph> <glyph class="state variable" id="_03af3871-040d-470a-9c6e-148b4f87d6b4"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="5624.882" y="3006.0"/> </glyph> <glyph class="state variable" id="_fc0ac252-5673-4ec4-ab8c-8473ec363e1d"> <state value="" variable="T157"/> <bbox w="30.0" h="10.0" x="5622.082" y="2966.0"/> </glyph> <glyph class="state variable" id="_19e12f41-db53-4501-9582-5e947a5e52b2"> <state value="" variable="T198"/> <bbox w="30.0" h="10.0" x="5545.5" y="3005.7224"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s80_akt1_akt2_sa74" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re31(MAP:survival): PMID:18636226 PMID:19887899 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B HUGO:DYRK1B HGNC:3092 ENTREZ:9149 UNIPROT:Q9Y463 GENECARDS:DYRK1B KEGG:9149 ATLASONC:DYRK1BID43235ch19q13 WIKI:DYRK1B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="DYRK1B"/> <bbox w="80.0" h="40.0" x="5677.0" y="3016.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s84_akt1_akt2_sa77" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re39:(MAP:survival) PMID:15147722 PMID:18006823 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27 Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="p27KIP1*"/> <clone/> <bbox w="80.0" h="40.0" x="5560.5" y="3152.0"/> <glyph class="state variable" id="_9b3a7cea-8e72-4e70-8ee9-441b444f40b0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5595.5" y="3147.0"/> </glyph> <glyph class="state variable" id="_e0fa7844-34d0-45ff-a11f-41d0e6b0adac"> <state value="" variable="S157"/> <bbox w="30.0" h="10.0" x="5625.5" y="3147.0"/> </glyph> <glyph class="state variable" id="_571f9ae5-bd63-4309-bb57-c99f6c998582"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5595.5" y="3187.0"/> </glyph> <glyph class="state variable" id="_fabaeba7-1954-4721-b0d4-888861d7de99"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5578.9316" y="3147.0"/> </glyph> <glyph class="state variable" id="_192ae6f2-2dce-428a-9938-ec4d5da51484"> <state value="" variable="S10"/> <bbox w="25.0" h="10.0" x="5548.0" y="3149.402"/> </glyph> <glyph class="state variable" id="_0c61c9a9-f827-4e74-a6d4-172ba51aab41"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="5624.882" y="3187.0"/> </glyph> <glyph class="state variable" id="_ee69b565-2e57-47e6-97b3-048151ca436d"> <state value="" variable="T157"/> <bbox w="30.0" h="10.0" x="5622.082" y="3147.0"/> </glyph> <glyph class="state variable" id="_0f5f61d2-fd15-4bd3-ac3c-22192ebdf963"> <state value="" variable="T198"/> <bbox w="30.0" h="10.0" x="5545.5" y="3186.7224"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s84_akt1_akt2_sa89" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re39:(MAP:survival) PMID:15147722 PMID:18006823 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27 Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="p27KIP1*"/> <clone/> <bbox w="80.0" h="40.0" x="6145.0" y="3142.0"/> <glyph class="state variable" id="_7a1a8d84-b00f-48b8-b03c-e58ff2befb43"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6180.0" y="3137.0"/> </glyph> <glyph class="state variable" id="_129bc8cb-f17b-4a27-8535-6564d187842b"> <state value="" variable="S157"/> <bbox w="30.0" h="10.0" x="6210.0" y="3137.0"/> </glyph> <glyph class="state variable" id="_695f0034-3ec6-48f6-88cb-a409bafd5e44"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6180.0" y="3177.0"/> </glyph> <glyph class="state variable" id="_a1f1bbc2-b8b1-41f4-8f87-79411db0224c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6163.4316" y="3137.0"/> </glyph> <glyph class="state variable" id="_80911eb1-c70a-4634-978c-e312db4b2ecf"> <state value="" variable="S10"/> <bbox w="25.0" h="10.0" x="6132.5" y="3139.402"/> </glyph> <glyph class="state variable" id="_868da0ea-24e9-498d-a980-7e21943db7a6"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="6209.382" y="3177.0"/> </glyph> <glyph class="state variable" id="_72057b09-72bc-4cc8-a110-6edda1e184f2"> <state value="" variable="T157"/> <bbox w="30.0" h="10.0" x="6206.582" y="3137.0"/> </glyph> <glyph class="state variable" id="_bd56e0b6-56f5-45bd-840a-d2bca58e7171"> <state value="" variable="T198"/> <bbox w="30.0" h="10.0" x="6130.0" y="3176.7224"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s85_akt1_akt2_sa79" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re31(MAP:survival): PMID:18636226 PMID:19887899 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: U2AF homo HUGO:UHMK1 HGNC:19683 ENTREZ:127933 UNIPROT:Q8TAS1 GENECARDS:UHMK1 KEGG:127933 ATLASONC:GC_UHMK1 WIKI:UHMK1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="KIS*"/> <bbox w="80.0" h="40.0" x="5397.0" y="3017.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s87_akt1_akt2_sa81" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re37(MAP:survival): PMID:18636226 PMID:15147722 PMID:14536078 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin E1 HUGO:CCNE1 HGNC:1589 ENTREZ:898 UNIPROT:P24864 GENECARDS:CCNE1 REACTOME:87225 KEGG:898 ATLASONC:GC_CCNE1 WIKI:CCNE1 cyclin E2 HUGO:CCNE2 HGNC:1590 ENTREZ:9134 UNIPROT:O96020 GENECARDS:CCNE2 REACTOME:87228 KEGG:9134 ATLASONC:GC_CCNE2 WIKI:CCNE2 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:cellcycle / MODULE:CYCLINE MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:15147722 PMID:14536078 References_end</body> </html> </notes> <label text="CyclinE*"/> <bbox w="80.0" h="40.0" x="5397.0" y="3067.0"/> <glyph class="state variable" id="_7626a95e-1afb-42ab-8fed-753757a624fe"> <state value="" variable="S384"/> <bbox w="30.0" h="10.0" x="5462.0" y="3062.2148"/> </glyph> <glyph class="state variable" id="_b2bb8e9d-90e4-44ff-88e2-24c48194a085"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5392.0" y="3102.0"/> </glyph> <glyph class="state variable" id="_a383e83a-202f-48fa-b257-bafae426fd1a"> <state value="" variable="T380"/> <bbox w="30.0" h="10.0" x="5382.0" y="3062.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s88_akt1_akt2_sa82" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re37(MAP:survival): PMID:18636226 PMID:15147722 PMID:14536078 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase 2 HUGO:CDK2 HGNC:1771 ENTREZ:1017 UNIPROT:P24941 GENECARDS:CDK2 REACTOME:87018 KEGG:1017 ATLASONC:GC_CDK2 WIKI:CDK2 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:dnarepair / MODULE:S_CC_PHASE MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:15147722 PMID:14536078 References_end</body> </html> </notes> <label text="CDK2"/> <bbox w="80.0" h="40.0" x="5397.0" y="3140.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s101_akt1_akt2_sa92" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re108:(MAP:survival) PMID:11313479 s_akt2_re123:(MAP:survival) PMID:11980723 PMID:14664696 s_wnc2_re87:(MAP:survival) PMID:10611249 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> </notes> <label text="CRM1*"/> <clone/> <bbox w="80.0" h="40.0" x="6321.0" y="3208.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s101_akt1_akt2_sa206" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re108:(MAP:survival) PMID:11313479 s_akt2_re123:(MAP:survival) PMID:11980723 PMID:14664696 s_wnc2_re87:(MAP:survival) PMID:10611249 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> </notes> <label text="CRM1*"/> <clone/> <bbox w="80.0" h="40.0" x="4830.5" y="3797.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s108_akt1_akt2_sa97" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re125:(MAP:survival) PMID:11980723 PMID:14664696 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> </notes> <label text="CRM1*"/> <clone/> <bbox w="80.0" h="40.0" x="6677.5" y="3307.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s108_akt1_akt2_sa211" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re125:(MAP:survival) PMID:11980723 PMID:14664696 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> </notes> <label text="CRM1*"/> <clone/> <bbox w="80.0" h="40.0" x="4542.5" y="3654.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s108_akt1_akt2_sa226" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re125:(MAP:survival) PMID:11980723 PMID:14664696 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> </notes> <label text="CRM1*"/> <clone/> <bbox w="80.0" h="40.0" x="4413.5" y="4125.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s109_akt1_akt2_sa98" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re45:(MAP:survival) PMID:18636226 s_akt2_re46:(MAP:survival) PMID:15531880 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27 Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="p27KIP1*"/> <bbox w="80.0" h="40.0" x="6765.0" y="3305.0"/> <glyph class="state variable" id="_49cd2941-7d12-40e5-8b93-ef096336d7dc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6800.0" y="3300.0"/> </glyph> <glyph class="state variable" id="_bf2cc1f3-2ec3-4397-80a2-5ce5feeb318a"> <state value="" variable="S157"/> <bbox w="30.0" h="10.0" x="6830.0" y="3300.0"/> </glyph> <glyph class="state variable" id="_e6b6b47b-e861-4c39-b7fb-1ad7e1389a99"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6800.0" y="3340.0"/> </glyph> <glyph class="state variable" id="_5fd89959-7dec-4920-901f-2a320b22dc5a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6783.4316" y="3300.0"/> </glyph> <glyph class="state variable" id="_e8a541bc-546a-4522-9c75-972434ee10a4"> <state value="" variable="S10"/> <bbox w="25.0" h="10.0" x="6752.5" y="3302.402"/> </glyph> <glyph class="state variable" id="_921ff3cb-9e0b-45c9-b125-ba03fca3fcac"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="6829.382" y="3340.0"/> </glyph> <glyph class="state variable" id="_9b1c5392-3009-4be2-9aef-9abb2bdf103a"> <state value="" variable="T157"/> <bbox w="30.0" h="10.0" x="6826.582" y="3300.0"/> </glyph> <glyph class="state variable" id="_6b446cb2-fd0d-46e4-9223-ea9d41ac883b"> <state value="" variable="T198"/> <bbox w="30.0" h="10.0" x="6750.0" y="3339.7224"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s133_akt1_akt2_sa117" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: CDC34 HUGO:CDC34 HGNC:1734 ENTREZ:997 UNIPROT:P49427 GENECARDS:CDC34 REACTOME:66737 KEGG:997 ATLASONC:GC_CDC34 WIKI:CDC34 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17329932 PMID:9367342 References_end Identifiers_begin: CDC34 HUGO:CDC34 HGNC:1734 ENTREZ:997 UNIPROT:P49427 GENECARDS:CDC34 REACTOME:66737 KEGG:997 ATLASONC:GC_CDC34 WIKI:CDC34 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17329932 PMID:9367342 References_end</body> </html> </notes> <label text="CDC34"/> <bbox w="80.0" h="40.0" x="5587.0" y="3569.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s135_akt1_akt2_sa119" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re54:(MAP:survival) PMID:14536078 s_akt2_re136:(MAP:survival) PMID:11124803 PMID:12459251 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end</body> </html> </notes> <label text="GSK3β*"/> <bbox w="80.0" h="40.0" x="5590.0" y="3353.0"/> <glyph class="state variable" id="_4bf4f4c5-bce0-46c7-a0ee-e93834883506"> <state value="" variable="S9"/> <bbox w="20.0" h="10.0" x="5580.4927" y="3348.0"/> </glyph> <glyph class="state variable" id="_8caf6008-31b5-42b7-a607-4cfd500caf6b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5585.0" y="3368.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s136_akt1_akt2_sa120" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re53:(MAP:survival) PMID:14536078 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin E1 HUGO:CCNE1 HGNC:1589 ENTREZ:898 UNIPROT:P24864 GENECARDS:CCNE1 REACTOME:87225 KEGG:898 ATLASONC:GC_CCNE1 WIKI:CCNE1 cyclin E2 HUGO:CCNE2 HGNC:1590 ENTREZ:9134 UNIPROT:O96020 GENECARDS:CCNE2 REACTOME:87228 KEGG:9134 ATLASONC:GC_CCNE2 WIKI:CCNE2 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:cellcycle / MODULE:CYCLINE MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:15147722 PMID:14536078 References_end</body> </html> </notes> <label text="CyclinE*"/> <bbox w="80.0" h="40.0" x="5516.5" y="3435.0"/> <glyph class="state variable" id="_8aceb9a8-5210-4052-90b4-423f72451321"> <state value="" variable="S384"/> <bbox w="30.0" h="10.0" x="5581.5" y="3430.2148"/> </glyph> <glyph class="state variable" id="_791d5314-9472-4805-9507-6618a74cb5b9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5511.5" y="3470.0"/> </glyph> <glyph class="state variable" id="_40fba6a4-34fc-4ffa-91de-e35679678598"> <state value="P" variable="T380"/> <bbox w="35.0" h="10.0" x="5499.0" y="3430.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s137_akt1_akt2_sa121" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re54:(MAP:survival) PMID:14536078 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin E1 HUGO:CCNE1 HGNC:1589 ENTREZ:898 UNIPROT:P24864 GENECARDS:CCNE1 REACTOME:87225 KEGG:898 ATLASONC:GC_CCNE1 WIKI:CCNE1 cyclin E2 HUGO:CCNE2 HGNC:1590 ENTREZ:9134 UNIPROT:O96020 GENECARDS:CCNE2 REACTOME:87228 KEGG:9134 ATLASONC:GC_CCNE2 WIKI:CCNE2 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:cellcycle / MODULE:CYCLINE MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:15147722 PMID:14536078 References_end</body> </html> </notes> <label text="CyclinE*"/> <bbox w="80.0" h="40.0" x="5662.5" y="3435.0"/> <glyph class="state variable" id="_54e15243-d0e4-4b6c-bcff-1123fcd9a68f"> <state value="P" variable="S384"/> <bbox w="35.0" h="10.0" x="5725.0" y="3430.2148"/> </glyph> <glyph class="state variable" id="_39c5e126-1d0b-49e3-b547-7fee31e877f8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5657.5" y="3470.0"/> </glyph> <glyph class="state variable" id="_d2ad3121-47c3-4bad-8d4b-c321330decd3"> <state value="P" variable="T380"/> <bbox w="35.0" h="10.0" x="5645.0" y="3430.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s144_akt1_akt2_sa126" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin E1 HUGO:CCNE1 HGNC:1589 ENTREZ:898 UNIPROT:P24864 GENECARDS:CCNE1 REACTOME:87225 KEGG:898 ATLASONC:GC_CCNE1 WIKI:CCNE1 cyclin E2 HUGO:CCNE2 HGNC:1590 ENTREZ:9134 UNIPROT:O96020 GENECARDS:CCNE2 REACTOME:87228 KEGG:9134 ATLASONC:GC_CCNE2 WIKI:CCNE2 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:cellcycle / MODULE:CYCLINE MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:15147722 PMID:14536078 References_end</body> </html> </notes> <label text="CyclinE*"/> <bbox w="80.0" h="40.0" x="5789.5" y="3435.0"/> <glyph class="state variable" id="_91b48af2-a191-411f-90a7-928463bccd91"> <state value="P" variable="S384"/> <bbox w="35.0" h="10.0" x="5852.0" y="3430.2148"/> </glyph> <glyph class="state variable" id="_f2df51f8-3b30-4666-abe5-645ff74299b4"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="5779.5" y="3470.0"/> </glyph> <glyph class="state variable" id="_1e42ad84-5bd7-4b5b-ab3f-79d2b257ba5c"> <state value="P" variable="T380"/> <bbox w="35.0" h="10.0" x="5772.0" y="3430.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s145_akt1_akt2_sa127" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re39:(MAP:survival) PMID:15147722 PMID:18006823 s_akt2_re46:(MAP:survival) PMID:15531880 s_akt2_re68:(MAP:survival) PMID:15169778 PMID:10722742 s_akt2_re70(MAP:survival): PMID:10721693 PMID:19459846 s_akt2_re149:(MAP:survival) PMID:19440234 s_wca3_re32:(MAP:survival) PMID:16714285 s_wnc3_re16(MAP:survival): Sequential sumoylion of NFAT1, might also occur in NFAT3 and 4. There is no special character for sumoylation in CellDesigner, so this is indicated by a "?". Lys684 is targeted firstly, followed by Lys897. PMID:15117942 s_wnc3_re18(MAP:survival): Order of sumoylation is not important. PMID:19218564 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> </notes> <label text="E1*"/> <bbox w="80.0" h="40.0" x="5682.75" y="3569.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s180_akt1_akt2_sa90" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re48:(MAP:survival) PMID:15147722 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27 Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="p27KIP1*"/> <bbox w="80.0" h="40.0" x="6745.0" y="3040.0"/> <glyph class="state variable" id="_a19354eb-13e3-42d9-abda-c62230a3854d"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="6775.0" y="3035.0"/> </glyph> <glyph class="state variable" id="_710e7da6-cbc4-462a-afd6-6f2d44d56327"> <state value="" variable="S157"/> <bbox w="30.0" h="10.0" x="6810.0" y="3035.0"/> </glyph> <glyph class="state variable" id="_6c34cb71-6662-4eb0-90af-2a52c38b6919"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="6775.0" y="3075.0"/> </glyph> <glyph class="state variable" id="_a9b24fca-3bba-4e42-b6b0-cd581c8e6914"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="6758.4316" y="3035.0"/> </glyph> <glyph class="state variable" id="_677baae3-c16e-4a37-ab43-2d3cac38fce4"> <state value="" variable="S10"/> <bbox w="25.0" h="10.0" x="6732.5" y="3037.402"/> </glyph> <glyph class="state variable" id="_57595462-2c77-4fb8-b969-7a19d6af8efe"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="6809.382" y="3075.0"/> </glyph> <glyph class="state variable" id="_39fbe98e-fc75-4f83-84d8-f3255bbd5d14"> <state value="" variable="T157"/> <bbox w="30.0" h="10.0" x="6806.582" y="3035.0"/> </glyph> <glyph class="state variable" id="_9e071a4a-8424-4dc2-a925-0d85b6b1bde9"> <state value="" variable="T198"/> <bbox w="30.0" h="10.0" x="6730.0" y="3074.7224"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s181_akt1_akt2_sa101" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re46:(MAP:survival) PMID:15531880 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27 Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="p27KIP1*"/> <bbox w="80.0" h="40.0" x="6764.0" y="3387.0"/> <glyph class="state variable" id="_63d7c93c-25a2-4a45-a396-bec6663e0b9b"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="6794.0" y="3382.0"/> </glyph> <glyph class="state variable" id="_c552d9d2-45b3-4760-9058-9365f6367732"> <state value="" variable="S157"/> <bbox w="30.0" h="10.0" x="6829.0" y="3382.0"/> </glyph> <glyph class="state variable" id="_827e2fdf-767d-46a4-bd90-9dc749168d72"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="6794.0" y="3422.0"/> </glyph> <glyph class="state variable" id="_ad618b8c-99e4-4a80-94f7-13ddb78e73e5"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="6777.4316" y="3382.0"/> </glyph> <glyph class="state variable" id="_91d90d12-260d-42c2-92cf-86b3664762f3"> <state value="" variable="S10"/> <bbox w="25.0" h="10.0" x="6751.5" y="3384.402"/> </glyph> <glyph class="state variable" id="_641a8a3f-37a3-4f28-ae67-d6bc6b1eaa73"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="6828.382" y="3422.0"/> </glyph> <glyph class="state variable" id="_239cae93-3ccf-42ce-a868-d074eabca54c"> <state value="" variable="T157"/> <bbox w="30.0" h="10.0" x="6825.582" y="3382.0"/> </glyph> <glyph class="state variable" id="_182c3751-5cba-4808-81d1-8a9f96a7b6fd"> <state value="" variable="T198"/> <bbox w="30.0" h="10.0" x="6749.0" y="3421.7224"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s182_akt1_akt2_sa142" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re140:(MAP:survival) PMID:18006823 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ring finger and CHY zinc finger domain containing 1 HUGO:RCHY1 HGNC:17479 ENTREZ:25898 UNIPROT:Q96PM5 GENECARDS:RCHY1 REACTOME:68078 KEGG:25898 ATLASONC:RCHY1ID43012ch04q21 WIKI:RCHY1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18006823 PMID:19459846 References_end</body> </html> </notes> <label text="PIRH2*"/> <clone/> <bbox w="80.0" h="40.0" x="5858.0" y="3135.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s182_akt1_akt2_sa273" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re140:(MAP:survival) PMID:18006823 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ring finger and CHY zinc finger domain containing 1 HUGO:RCHY1 HGNC:17479 ENTREZ:25898 UNIPROT:Q96PM5 GENECARDS:RCHY1 REACTOME:68078 KEGG:25898 ATLASONC:RCHY1ID43012ch04q21 WIKI:RCHY1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18006823 PMID:19459846 References_end</body> </html> </notes> <label text="PIRH2*"/> <clone/> <bbox w="80.0" h="40.0" x="6089.0" y="3380.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s184_akt1_akt2_sa143" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re66:(MAP:survival) PMID15169778 s_akt2_re68:(MAP:survival) PMID:15169778 PMID:10722742 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 References_end Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 GENECARDS:MDM2 REACTOME:95018 KEGG:4193 ATLASONC:MDM2ID115ch12q15 WIKI:MDM2 Mdm2 p53 binding protein homolog (mouse) Mdm2 p53 binding protein homo Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:CYCLINB MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 PMID:20679392 PMID:15169778 PMID:11923280 PMID:11715018 References_end Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 GENECARDS:MDM2 REACTOME:95018 KEGG:4193 ATLASONC:MDM2ID115ch12q15 WIKI:MDM2 Mdm2 p53 binding protein homolog (mouse) Mdm2 p53 binding protein homo Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:CYCLINB MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 PMID:20679392 PMID:15169778 PMID:11923280 PMID:11715018 References_end</body> </html> </notes> <label text="MDM2"/> <bbox w="80.0" h="40.0" x="5902.0" y="4337.0"/> <glyph class="state variable" id="_f6d882cd-ab7e-42e2-82b7-60b53ed83332"> <state value="" variable="S166"/> <bbox w="30.0" h="10.0" x="5887.0" y="4332.93"/> </glyph> <glyph class="state variable" id="_bdda28d3-22b2-43ee-a0c3-20c071ed4178"> <state value="" variable="S186"/> <bbox w="30.0" h="10.0" x="5967.0" y="4332.991"/> </glyph> <glyph class="state variable" id="_38a92440-8bc9-4891-bcff-c1c3e4b28743"> <state value="" variable="S188"/> <bbox w="30.0" h="10.0" x="5966.382" y="4372.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s185_akt1_akt2_sa144" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re66:(MAP:survival) PMID15169778 s_akt2_re68:(MAP:survival) PMID:15169778 PMID:10722742 s_akt2_re70(MAP:survival): PMID:10721693 PMID:19459846 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 References_end Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 GENECARDS:MDM2 REACTOME:95018 KEGG:4193 ATLASONC:MDM2ID115ch12q15 WIKI:MDM2 Mdm2 p53 binding protein homolog (mouse) Mdm2 p53 binding protein homo Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:CYCLINB MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 PMID:20679392 PMID:15169778 PMID:11923280 PMID:11715018 References_end Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 GENECARDS:MDM2 REACTOME:95018 KEGG:4193 ATLASONC:MDM2ID115ch12q15 WIKI:MDM2 Mdm2 p53 binding protein homolog (mouse) Mdm2 p53 binding protein homo Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:CYCLINB MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 PMID:20679392 PMID:15169778 PMID:11923280 PMID:11715018 References_end</body> </html> </notes> <label text="MDM2"/> <bbox w="80.0" h="40.0" x="5902.0" y="4437.0"/> <glyph class="state variable" id="_593f8666-f261-49fd-b615-3c5dd46bec70"> <state value="" variable="S166"/> <bbox w="30.0" h="10.0" x="5887.0" y="4432.93"/> </glyph> <glyph class="state variable" id="_01683b6c-bfa0-4649-9ebc-9488674ba1ed"> <state value="" variable="S186"/> <bbox w="30.0" h="10.0" x="5967.0" y="4432.991"/> </glyph> <glyph class="state variable" id="_cbe80469-6f32-4444-97e9-be25829ae3e1"> <state value="" variable="S188"/> <bbox w="30.0" h="10.0" x="5966.382" y="4472.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s188_akt1_akt2_sa147" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 References_end Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end</body> </html> Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end</body> </html> Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end</body> </html> </notes> <label text="p53*"/> <bbox w="80.0" h="40.0" x="5927.0" y="4207.0"/> <glyph class="state variable" id="_1436f072-311b-4ec2-a9de-8be2753bebe3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6002.0" y="4242.0"/> </glyph> <glyph class="state variable" id="_54f89fec-e604-418e-b6a7-0626ae1f7552"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5922.0" y="4202.0"/> </glyph> <glyph class="state variable" id="_71287567-3c67-4094-9b1d-97345d18f244"> <state value="" variable="S46"/> <bbox w="25.0" h="10.0" x="5994.5" y="4202.215"/> </glyph> <glyph class="state variable" id="_5d97f31f-387d-4cf7-a862-fe27ed00af6d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5922.0" y="4222.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s189_akt1_akt2_sa148" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re39:(MAP:survival) PMID:15147722 PMID:18006823 s_akt2_re68:(MAP:survival) PMID:15169778 PMID:10722742 s_akt2_re70(MAP:survival): PMID:10721693 PMID:19459846 s_akt2_re149:(MAP:survival) PMID:19440234 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C ubiquitin-conjugating enzyme E2D 1 HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 ubiquitin-conjugating enzyme E2E 1 HUGO:UBE2E1 HGNC:12477 ENTREZ:7324 UNIPROT:P51965 GENECARDS:UBE2E1 REACTOME:66739 KEGG:7324 ATLASONC:GC_UBE2E1 WIKI:UBE2E1 ubiquitin-conjugating enzyme E2E 2 HUGO:UBE2E2 HGNC:12478 ENTREZ:7325 UNIPROT:Q96LR5 GENECARDS:UBE2E2 REACTOME:155471 KEGG:7325 ATLASONC:GC_UBE2E2 WIKI:UBE2E2 ubiquitin-conjugating enzyme E2G 1 HUGO:UBE2G1 HGNC:12482 ENTREZ:7326 UNIPROT:P62253 GENECARDS:UBE2G1 REACTOME:66753 KEGG:7326 ATLASONC:GC_UBE2G1 WIKI:UBE2G1 ubiquitin-conjugating enzyme E2G 2 HUGO:UBE2G2 HGNC:12483 ENTREZ:7327 UNIPROT:P60604 GENECARDS:UBE2G2 REACTOME:66773 KEGG:7327 ATLASONC:GC_UBE2G2 WIKI:UBE2G2 ubiquitin-conjugating enzyme E2H HUGO:UBE2H HGNC:12484 ENTREZ:7328 UNIPROT:P62256 GENECARDS:UBE2H REACTOME:66759 KEGG:7328 ATLASONC:GC_UBE2H WIKI:UBE2H ubiquitin-conjugating enzyme E2I HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I ubiquitin-conjugating enzyme E2 J1 HUGO:UBE2J1 HGNC:17598 ENTREZ:51465 UNIPROT:Q9Y385 GENECARDS:UBE2J1 REACTOME:155484 KEGG:51465 ATLASONC:GC_UBE2J1 WIKI:UBE2J1 ubiquitin-conjugating enzyme E2 J2 HUGO:UBE2J2 HGNC:19268 ENTREZ:118424 UNIPROT:Q8N2K1 GENECARDS:UBE2J2 REACTOME:155486 KEGG:118424 WIKI:UBE2J2 ubiquitin-conjugating enzyme E2K HUGO:UBE2K HGNC:4914 ENTREZ:3093 UNIPROT:P61086 GENECARDS:UBE2K REACTOME:66723 KEGG:3093 WIKI:UBE2K ubiquitin-conjugating enzyme E2L 3 HUGO:UBE2L3 HGNC:12488 ENTREZ:7332 UNIPROT:P68036 GENECARDS:UBE2L3 REACTOME:66741 KEGG:7332 ATLASONC:GC_UBE2L3 WIKI:UBE2L3 ubiquitin-conjugating enzyme E2L 4 HUGO:UBE2L4 HGNC:12489 ENTREZ:7333 GENECARDS:UBE2L4 WIKI:UBE2L4 ubiquitin-conjugating enzyme E2L 6 HUGO:UBE2L6 HGNC:12490 ENTREZ:9246 UNIPROT:O14933 GENECARDS:UBE2L6 REACTOME:66745 KEGG:9246 ATLASONC:GC_UBE2L6 WIKI:UBE2L6 ubiquitin-conjugating enzyme E2M HUGO:UBE2M HGNC:12491 ENTREZ:9040 UNIPROT:P61081 GENECARDS:UBE2M REACTOME:66777 KEGG:9040 ATLASONC:GC_UBE2M WIKI:UBE2M ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 GENECARDS:UBE2N REACTOME:66781 KEGG:7334 ATLASONC:GC_UBE2N WIKI:UBE2N ubiquitin-conjugating enzyme E2O HUGO:UBE2O HGNC:29554 ENTREZ:63893 UNIPROT:Q9C0C9 GENECARDS:UBE2O REACTOME:253534 KEGG:63893 ATLASONC:GC_UBE2O WIKI:UBE2O ubiquitin-conjugating enzyme E2Q family member 1 HUGO:UBE2Q1 HGNC:15698 ENTREZ:55585 UNIPROT:Q7Z7E8 GENECARDS:UBE2Q1 REACTOME:253474 KEGG:55585 ATLASONC:GC_UBE2Q1 WIKI:UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 2 HUGO:UBE2Q2 HGNC:19248 ENTREZ:92912 UNIPROT:Q8WVN8 GENECARDS:UBE2Q2 REACTOME:253479 ATLASONC:GC_UBE2Q2 WIKI:UBE2Q2 ubiquitin-conjugating enzyme E2R 2 HUGO:UBE2R2 HGNC:19907 ENTREZ:54926 UNIPROT:Q712K3 GENECARDS:UBE2R2 REACTOME:253483 KEGG:54926 ATLASONC:GC_UBE2R2 WIKI:UBE2R2 ubiquitin-conjugating enzyme E2S HUGO:UBE2S HGNC:17895 ENTREZ:27338 UNIPROT:Q16763 GENECARDS:UBE2S REACTOME:66751 KEGG:27338 ATLASONC:GC_UBE2S WIKI:UBE2S ubiquitin-conjugating enzyme E2Z HUGO:UBE2Z HGNC:25847 ENTREZ:65264 UNIPROT:Q9H832 GENECARDS:UBE2Z REACTOME:253545 KEGG:65264 WIKI:UBE2Z Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C ubiquitin-conjugating enzyme E2D 1 HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 ubiquitin-conjugating enzyme E2E 1 HUGO:UBE2E1 HGNC:12477 ENTREZ:7324 UNIPROT:P51965 GENECARDS:UBE2E1 REACTOME:66739 KEGG:7324 ATLASONC:GC_UBE2E1 WIKI:UBE2E1 ubiquitin-conjugating enzyme E2E 2 HUGO:UBE2E2 HGNC:12478 ENTREZ:7325 UNIPROT:Q96LR5 GENECARDS:UBE2E2 REACTOME:155471 KEGG:7325 ATLASONC:GC_UBE2E2 WIKI:UBE2E2 ubiquitin-conjugating enzyme E2G 1 HUGO:UBE2G1 HGNC:12482 ENTREZ:7326 UNIPROT:P62253 GENECARDS:UBE2G1 REACTOME:66753 KEGG:7326 ATLASONC:GC_UBE2G1 WIKI:UBE2G1 ubiquitin-conjugating enzyme E2G 2 HUGO:UBE2G2 HGNC:12483 ENTREZ:7327 UNIPROT:P60604 GENECARDS:UBE2G2 REACTOME:66773 KEGG:7327 ATLASONC:GC_UBE2G2 WIKI:UBE2G2 ubiquitin-conjugating enzyme E2H HUGO:UBE2H HGNC:12484 ENTREZ:7328 UNIPROT:P62256 GENECARDS:UBE2H REACTOME:66759 KEGG:7328 ATLASONC:GC_UBE2H WIKI:UBE2H ubiquitin-conjugating enzyme E2I HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I ubiquitin-conjugating enzyme E2 J1 HUGO:UBE2J1 HGNC:17598 ENTREZ:51465 UNIPROT:Q9Y385 GENECARDS:UBE2J1 REACTOME:155484 KEGG:51465 ATLASONC:GC_UBE2J1 WIKI:UBE2J1 ubiquitin-conjugating enzyme E2 J2 HUGO:UBE2J2 HGNC:19268 ENTREZ:118424 UNIPROT:Q8N2K1 GENECARDS:UBE2J2 REACTOME:155486 KEGG:118424 WIKI:UBE2J2 ubiquitin-conjugating enzyme E2K HUGO:UBE2K HGNC:4914 ENTREZ:3093 UNIPROT:P61086 GENECARDS:UBE2K REACTOME:66723 KEGG:3093 WIKI:UBE2K ubiquitin-conjugating enzyme E2L 3 HUGO:UBE2L3 HGNC:12488 ENTREZ:7332 UNIPROT:P68036 GENECARDS:UBE2L3 REACTOME:66741 KEGG:7332 ATLASONC:GC_UBE2L3 WIKI:UBE2L3 ubiquitin-conjugating enzyme E2L 4 HUGO:UBE2L4 HGNC:12489 ENTREZ:7333 GENECARDS:UBE2L4 WIKI:UBE2L4 ubiquitin-conjugating enzyme E2L 6 HUGO:UBE2L6 HGNC:12490 ENTREZ:9246 UNIPROT:O14933 GENECARDS:UBE2L6 REACTOME:66745 KEGG:9246 ATLASONC:GC_UBE2L6 WIKI:UBE2L6 ubiquitin-conjugating enzyme E2M HUGO:UBE2M HGNC:12491 ENTREZ:9040 UNIPROT:P61081 GENECARDS:UBE2M REACTOME:66777 KEGG:9040 ATLASONC:GC_UBE2M WIKI:UBE2M ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 GENECARDS:UBE2N REACTOME:66781 KEGG:7334 ATLASONC:GC_UBE2N WIKI:UBE2N ubiquitin-conjugating enzyme E2O HUGO:UBE2O HGNC:29554 ENTREZ:63893 UNIPROT:Q9C0C9 GENECARDS:UBE2O REACTOME:253534 KEGG:63893 ATLASONC:GC_UBE2O WIKI:UBE2O ubiquitin-conjugating enzyme E2Q family member 1 HUGO:UBE2Q1 HGNC:15698 ENTREZ:55585 UNIPROT:Q7Z7E8 GENECARDS:UBE2Q1 REACTOME:253474 KEGG:55585 ATLASONC:GC_UBE2Q1 WIKI:UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 2 HUGO:UBE2Q2 HGNC:19248 ENTREZ:92912 UNIPROT:Q8WVN8 GENECARDS:UBE2Q2 REACTOME:253479 ATLASONC:GC_UBE2Q2 WIKI:UBE2Q2 ubiquitin-conjugating enzyme E2R 2 HUGO:UBE2R2 HGNC:19907 ENTREZ:54926 UNIPROT:Q712K3 GENECARDS:UBE2R2 REACTOME:253483 KEGG:54926 ATLASONC:GC_UBE2R2 WIKI:UBE2R2 ubiquitin-conjugating enzyme E2S HUGO:UBE2S HGNC:17895 ENTREZ:27338 UNIPROT:Q16763 GENECARDS:UBE2S REACTOME:66751 KEGG:27338 ATLASONC:GC_UBE2S WIKI:UBE2S ubiquitin-conjugating enzyme E2Z HUGO:UBE2Z HGNC:25847 ENTREZ:65264 UNIPROT:Q9H832 GENECARDS:UBE2Z REACTOME:253545 KEGG:65264 WIKI:UBE2Z Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C ubiquitin-conjugating enzyme E2D 1 HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 ubiquitin-conjugating enzyme E2E 1 HUGO:UBE2E1 HGNC:12477 ENTREZ:7324 UNIPROT:P51965 GENECARDS:UBE2E1 REACTOME:66739 KEGG:7324 ATLASONC:GC_UBE2E1 WIKI:UBE2E1 ubiquitin-conjugating enzyme E2E 2 HUGO:UBE2E2 HGNC:12478 ENTREZ:7325 UNIPROT:Q96LR5 GENECARDS:UBE2E2 REACTOME:155471 KEGG:7325 ATLASONC:GC_UBE2E2 WIKI:UBE2E2 ubiquitin-conjugating enzyme E2G 1 HUGO:UBE2G1 HGNC:12482 ENTREZ:7326 UNIPROT:P62253 GENECARDS:UBE2G1 REACTOME:66753 KEGG:7326 ATLASONC:GC_UBE2G1 WIKI:UBE2G1 ubiquitin-conjugating enzyme E2G 2 HUGO:UBE2G2 HGNC:12483 ENTREZ:7327 UNIPROT:P60604 GENECARDS:UBE2G2 REACTOME:66773 KEGG:7327 ATLASONC:GC_UBE2G2 WIKI:UBE2G2 ubiquitin-conjugating enzyme E2H HUGO:UBE2H HGNC:12484 ENTREZ:7328 UNIPROT:P62256 GENECARDS:UBE2H REACTOME:66759 KEGG:7328 ATLASONC:GC_UBE2H WIKI:UBE2H ubiquitin-conjugating enzyme E2I HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I ubiquitin-conjugating enzyme E2 J1 HUGO:UBE2J1 HGNC:17598 ENTREZ:51465 UNIPROT:Q9Y385 GENECARDS:UBE2J1 REACTOME:155484 KEGG:51465 ATLASONC:GC_UBE2J1 WIKI:UBE2J1 ubiquitin-conjugating enzyme E2 J2 HUGO:UBE2J2 HGNC:19268 ENTREZ:118424 UNIPROT:Q8N2K1 GENECARDS:UBE2J2 REACTOME:155486 KEGG:118424 WIKI:UBE2J2 ubiquitin-conjugating enzyme E2K HUGO:UBE2K HGNC:4914 ENTREZ:3093 UNIPROT:P61086 GENECARDS:UBE2K REACTOME:66723 KEGG:3093 WIKI:UBE2K ubiquitin-conjugating enzyme E2L 3 HUGO:UBE2L3 HGNC:12488 ENTREZ:7332 UNIPROT:P68036 GENECARDS:UBE2L3 REACTOME:66741 KEGG:7332 ATLASONC:GC_UBE2L3 WIKI:UBE2L3 ubiquitin-conjugating enzyme E2L 4 HUGO:UBE2L4 HGNC:12489 ENTREZ:7333 GENECARDS:UBE2L4 WIKI:UBE2L4 ubiquitin-conjugating enzyme E2L 6 HUGO:UBE2L6 HGNC:12490 ENTREZ:9246 UNIPROT:O14933 GENECARDS:UBE2L6 REACTOME:66745 KEGG:9246 ATLASONC:GC_UBE2L6 WIKI:UBE2L6 ubiquitin-conjugating enzyme E2M HUGO:UBE2M HGNC:12491 ENTREZ:9040 UNIPROT:P61081 GENECARDS:UBE2M REACTOME:66777 KEGG:9040 ATLASONC:GC_UBE2M WIKI:UBE2M ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 GENECARDS:UBE2N REACTOME:66781 KEGG:7334 ATLASONC:GC_UBE2N WIKI:UBE2N ubiquitin-conjugating enzyme E2O HUGO:UBE2O HGNC:29554 ENTREZ:63893 UNIPROT:Q9C0C9 GENECARDS:UBE2O REACTOME:253534 KEGG:63893 ATLASONC:GC_UBE2O WIKI:UBE2O ubiquitin-conjugating enzyme E2Q family member 1 HUGO:UBE2Q1 HGNC:15698 ENTREZ:55585 UNIPROT:Q7Z7E8 GENECARDS:UBE2Q1 REACTOME:253474 KEGG:55585 ATLASONC:GC_UBE2Q1 WIKI:UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 2 HUGO:UBE2Q2 HGNC:19248 ENTREZ:92912 UNIPROT:Q8WVN8 GENECARDS:UBE2Q2 REACTOME:253479 ATLASONC:GC_UBE2Q2 WIKI:UBE2Q2 ubiquitin-conjugating enzyme E2R 2 HUGO:UBE2R2 HGNC:19907 ENTREZ:54926 UNIPROT:Q712K3 GENECARDS:UBE2R2 REACTOME:253483 KEGG:54926 ATLASONC:GC_UBE2R2 WIKI:UBE2R2 ubiquitin-conjugating enzyme E2S HUGO:UBE2S HGNC:17895 ENTREZ:27338 UNIPROT:Q16763 GENECARDS:UBE2S REACTOME:66751 KEGG:27338 ATLASONC:GC_UBE2S WIKI:UBE2S ubiquitin-conjugating enzyme E2Z HUGO:UBE2Z HGNC:25847 ENTREZ:65264 UNIPROT:Q9H832 GENECARDS:UBE2Z REACTOME:253545 KEGG:65264 WIKI:UBE2Z Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> </notes> <label text="E2*"/> <bbox w="80.0" h="40.0" x="5779.0" y="3569.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s190_akt1_akt2_sa149" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re68:(MAP:survival) PMID:15169778 PMID:10722742 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 References_end Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 GENECARDS:MDM2 REACTOME:95018 KEGG:4193 ATLASONC:MDM2ID115ch12q15 WIKI:MDM2 Mdm2 p53 binding protein homolog (mouse) Mdm2 p53 binding protein homo Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:CYCLINB MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 PMID:20679392 PMID:15169778 PMID:11923280 PMID:11715018 References_end Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 GENECARDS:MDM2 REACTOME:95018 KEGG:4193 ATLASONC:MDM2ID115ch12q15 WIKI:MDM2 Mdm2 p53 binding protein homolog (mouse) Mdm2 p53 binding protein homo Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:CYCLINB MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 PMID:20679392 PMID:15169778 PMID:11923280 PMID:11715018 References_end</body> </html> </notes> <label text="MDM2"/> <bbox w="80.0" h="40.0" x="5792.0" y="4337.0"/> <glyph class="state variable" id="_3169a5ed-99c9-44bc-af5e-fe84b5cb1edb"> <state value="" variable="S166"/> <bbox w="30.0" h="10.0" x="5777.0" y="4332.93"/> </glyph> <glyph class="state variable" id="_25e6d40e-f9b4-4d7c-960c-1b95e785a278"> <state value="" variable="S186"/> <bbox w="30.0" h="10.0" x="5857.0" y="4332.991"/> </glyph> <glyph class="state variable" id="_cd45d716-f49b-45a8-9027-340d682cbac7"> <state value="" variable="S188"/> <bbox w="30.0" h="10.0" x="5856.382" y="4372.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s191_akt1_akt2_sa150" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re70(MAP:survival): PMID:10721693 PMID:19459846 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 References_end Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end</body> </html> </notes> <label text="p53*"/> <bbox w="80.0" h="40.0" x="6083.5" y="4207.0"/> <glyph class="state variable" id="_fbdc2db0-8edf-4631-a339-ea910720da22"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6158.5" y="4242.0"/> </glyph> <glyph class="state variable" id="_bcffb297-f42c-45b7-9de5-37a8ec93d779"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="6073.5" y="4202.0"/> </glyph> <glyph class="state variable" id="_2a769fb7-41ac-487f-a1cb-01d92fffb3bd"> <state value="" variable="S46"/> <bbox w="25.0" h="10.0" x="6151.0" y="4202.215"/> </glyph> <glyph class="state variable" id="_93858b6f-4420-4fca-82c4-fdebc69ceeb3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6078.5" y="4222.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s192_akt1_akt2_sa151" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 References_end Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end</body> </html> Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end</body> </html> Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end</body> </html> </notes> <label text="p53*"/> <bbox w="80.0" h="40.0" x="6098.5" y="4830.0"/> <glyph class="state variable" id="_e225fe46-8bc5-44e6-bbda-9187f8c9b152"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6173.5" y="4865.0"/> </glyph> <glyph class="state variable" id="_df259213-92b9-4ad7-aae9-f10c1e244d8b"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="6088.5" y="4825.0"/> </glyph> <glyph class="state variable" id="_acc22fa2-0022-491f-a386-627388bc4327"> <state value="" variable="S46"/> <bbox w="25.0" h="10.0" x="6166.0" y="4825.215"/> </glyph> <glyph class="state variable" id="_24053f1c-585d-46ef-9de2-7f145c96394d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6093.5" y="4845.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s193_akt1_akt2_sa152" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re75:(MAP:survival) PMID:19321440 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 GENECARDS:FOXO3 REACTOME:199273 KEGG:2309 ATLASONC:AF6q21ID125 WIKI:FOXO3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16288288 PMID:17646672 References_end</body> </html> </notes> <label text="FOXO3"/> <bbox w="80.0" h="40.0" x="4432.25" y="2953.0"/> <glyph class="state variable" id="_c52a5c99-5641-43e7-af08-6d9078ee0c91"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4467.25" y="2948.0"/> </glyph> <glyph class="state variable" id="_5e17ac39-ad53-485f-8639-163550cac429"> <state value="" variable="S644"/> <bbox w="30.0" h="10.0" x="4417.25" y="2987.7224"/> </glyph> <glyph class="state variable" id="_8a2d0192-7c51-4c5f-9bc8-f8d5604787fd"> <state value="" variable="T32"/> <bbox w="25.0" h="10.0" x="4419.75" y="2948.9302"/> </glyph> <glyph class="state variable" id="_db709f72-3c33-4fb4-8220-0b81e8d93e74"> <state value="" variable="S253"/> <bbox w="30.0" h="10.0" x="4497.25" y="2987.1306"/> </glyph> <glyph class="state variable" id="_17ea7368-fbea-48f3-ae99-10af1d1fd50b"> <state value="" variable="S315"/> <bbox w="30.0" h="10.0" x="4493.832" y="2948.0"/> </glyph> <glyph class="state variable" id="_eda09f37-4442-44b5-a54a-1bb2ef5c19f6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4427.25" y="2968.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s197_akt1_akt2_sa154" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re75:(MAP:survival) PMID:19321440 s_akt2_re127:(MAP:survival) PMID:15084260 s_wnc2_re72(MAP:survival): Where exactly MDM2 ubiquitinates NFAT is not known and also not known if it is in the cytosol or nucleus. PMID:16307918 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 References_end Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 GENECARDS:MDM2 REACTOME:95018 KEGG:4193 ATLASONC:MDM2ID115ch12q15 WIKI:MDM2 Mdm2 p53 binding protein homolog (mouse) Mdm2 p53 binding protein homo Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:CYCLINB MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 PMID:20679392 PMID:15169778 PMID:11923280 PMID:11715018 References_end Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 GENECARDS:MDM2 REACTOME:95018 KEGG:4193 ATLASONC:MDM2ID115ch12q15 WIKI:MDM2 Mdm2 p53 binding protein homolog (mouse) Mdm2 p53 binding protein homo Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:CYCLINB MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 PMID:20679392 PMID:15169778 PMID:11923280 PMID:11715018 References_end</body> </html> </notes> <label text="MDM2"/> <bbox w="80.0" h="40.0" x="4423.0" y="2636.366"/> <glyph class="state variable" id="_9aae2a3a-590a-4a2d-8c4b-bccbe929bb22"> <state value="" variable="S166"/> <bbox w="30.0" h="10.0" x="4408.0" y="2632.2961"/> </glyph> <glyph class="state variable" id="_071d23c5-6339-4f30-8246-de557332e4bc"> <state value="" variable="S186"/> <bbox w="30.0" h="10.0" x="4488.0" y="2632.357"/> </glyph> <glyph class="state variable" id="_5fe34221-4d48-42d6-b711-91b5058d3179"> <state value="" variable="S188"/> <bbox w="30.0" h="10.0" x="4487.382" y="2671.366"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s200_akt1_akt2_sa157" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> </notes> <label text="E1*"/> <clone/> <bbox w="80.0" h="40.0" x="4543.8438" y="2636.278"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s200_akt1_akt2_sa244" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> </notes> <label text="E1*"/> <clone/> <bbox w="80.0" h="40.0" x="4768.375" y="4995.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s201_akt1_akt2_sa158" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C ubiquitin-conjugating enzyme E2D 1 HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 ubiquitin-conjugating enzyme E2E 1 HUGO:UBE2E1 HGNC:12477 ENTREZ:7324 UNIPROT:P51965 GENECARDS:UBE2E1 REACTOME:66739 KEGG:7324 ATLASONC:GC_UBE2E1 WIKI:UBE2E1 ubiquitin-conjugating enzyme E2E 2 HUGO:UBE2E2 HGNC:12478 ENTREZ:7325 UNIPROT:Q96LR5 GENECARDS:UBE2E2 REACTOME:155471 KEGG:7325 ATLASONC:GC_UBE2E2 WIKI:UBE2E2 ubiquitin-conjugating enzyme E2G 1 HUGO:UBE2G1 HGNC:12482 ENTREZ:7326 UNIPROT:P62253 GENECARDS:UBE2G1 REACTOME:66753 KEGG:7326 ATLASONC:GC_UBE2G1 WIKI:UBE2G1 ubiquitin-conjugating enzyme E2G 2 HUGO:UBE2G2 HGNC:12483 ENTREZ:7327 UNIPROT:P60604 GENECARDS:UBE2G2 REACTOME:66773 KEGG:7327 ATLASONC:GC_UBE2G2 WIKI:UBE2G2 ubiquitin-conjugating enzyme E2H HUGO:UBE2H HGNC:12484 ENTREZ:7328 UNIPROT:P62256 GENECARDS:UBE2H REACTOME:66759 KEGG:7328 ATLASONC:GC_UBE2H WIKI:UBE2H ubiquitin-conjugating enzyme E2I HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I ubiquitin-conjugating enzyme E2 J1 HUGO:UBE2J1 HGNC:17598 ENTREZ:51465 UNIPROT:Q9Y385 GENECARDS:UBE2J1 REACTOME:155484 KEGG:51465 ATLASONC:GC_UBE2J1 WIKI:UBE2J1 ubiquitin-conjugating enzyme E2 J2 HUGO:UBE2J2 HGNC:19268 ENTREZ:118424 UNIPROT:Q8N2K1 GENECARDS:UBE2J2 REACTOME:155486 KEGG:118424 WIKI:UBE2J2 ubiquitin-conjugating enzyme E2K HUGO:UBE2K HGNC:4914 ENTREZ:3093 UNIPROT:P61086 GENECARDS:UBE2K REACTOME:66723 KEGG:3093 WIKI:UBE2K ubiquitin-conjugating enzyme E2L 3 HUGO:UBE2L3 HGNC:12488 ENTREZ:7332 UNIPROT:P68036 GENECARDS:UBE2L3 REACTOME:66741 KEGG:7332 ATLASONC:GC_UBE2L3 WIKI:UBE2L3 ubiquitin-conjugating enzyme E2L 4 HUGO:UBE2L4 HGNC:12489 ENTREZ:7333 GENECARDS:UBE2L4 WIKI:UBE2L4 ubiquitin-conjugating enzyme E2L 6 HUGO:UBE2L6 HGNC:12490 ENTREZ:9246 UNIPROT:O14933 GENECARDS:UBE2L6 REACTOME:66745 KEGG:9246 ATLASONC:GC_UBE2L6 WIKI:UBE2L6 ubiquitin-conjugating enzyme E2M HUGO:UBE2M HGNC:12491 ENTREZ:9040 UNIPROT:P61081 GENECARDS:UBE2M REACTOME:66777 KEGG:9040 ATLASONC:GC_UBE2M WIKI:UBE2M ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 GENECARDS:UBE2N REACTOME:66781 KEGG:7334 ATLASONC:GC_UBE2N WIKI:UBE2N ubiquitin-conjugating enzyme E2O HUGO:UBE2O HGNC:29554 ENTREZ:63893 UNIPROT:Q9C0C9 GENECARDS:UBE2O REACTOME:253534 KEGG:63893 ATLASONC:GC_UBE2O WIKI:UBE2O ubiquitin-conjugating enzyme E2Q family member 1 HUGO:UBE2Q1 HGNC:15698 ENTREZ:55585 UNIPROT:Q7Z7E8 GENECARDS:UBE2Q1 REACTOME:253474 KEGG:55585 ATLASONC:GC_UBE2Q1 WIKI:UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 2 HUGO:UBE2Q2 HGNC:19248 ENTREZ:92912 UNIPROT:Q8WVN8 GENECARDS:UBE2Q2 REACTOME:253479 ATLASONC:GC_UBE2Q2 WIKI:UBE2Q2 ubiquitin-conjugating enzyme E2R 2 HUGO:UBE2R2 HGNC:19907 ENTREZ:54926 UNIPROT:Q712K3 GENECARDS:UBE2R2 REACTOME:253483 KEGG:54926 ATLASONC:GC_UBE2R2 WIKI:UBE2R2 ubiquitin-conjugating enzyme E2S HUGO:UBE2S HGNC:17895 ENTREZ:27338 UNIPROT:Q16763 GENECARDS:UBE2S REACTOME:66751 KEGG:27338 ATLASONC:GC_UBE2S WIKI:UBE2S ubiquitin-conjugating enzyme E2Z HUGO:UBE2Z HGNC:25847 ENTREZ:65264 UNIPROT:Q9H832 GENECARDS:UBE2Z REACTOME:253545 KEGG:65264 WIKI:UBE2Z Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C ubiquitin-conjugating enzyme E2D 1 HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 ubiquitin-conjugating enzyme E2E 1 HUGO:UBE2E1 HGNC:12477 ENTREZ:7324 UNIPROT:P51965 GENECARDS:UBE2E1 REACTOME:66739 KEGG:7324 ATLASONC:GC_UBE2E1 WIKI:UBE2E1 ubiquitin-conjugating enzyme E2E 2 HUGO:UBE2E2 HGNC:12478 ENTREZ:7325 UNIPROT:Q96LR5 GENECARDS:UBE2E2 REACTOME:155471 KEGG:7325 ATLASONC:GC_UBE2E2 WIKI:UBE2E2 ubiquitin-conjugating enzyme E2G 1 HUGO:UBE2G1 HGNC:12482 ENTREZ:7326 UNIPROT:P62253 GENECARDS:UBE2G1 REACTOME:66753 KEGG:7326 ATLASONC:GC_UBE2G1 WIKI:UBE2G1 ubiquitin-conjugating enzyme E2G 2 HUGO:UBE2G2 HGNC:12483 ENTREZ:7327 UNIPROT:P60604 GENECARDS:UBE2G2 REACTOME:66773 KEGG:7327 ATLASONC:GC_UBE2G2 WIKI:UBE2G2 ubiquitin-conjugating enzyme E2H HUGO:UBE2H HGNC:12484 ENTREZ:7328 UNIPROT:P62256 GENECARDS:UBE2H REACTOME:66759 KEGG:7328 ATLASONC:GC_UBE2H WIKI:UBE2H ubiquitin-conjugating enzyme E2I HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I ubiquitin-conjugating enzyme E2 J1 HUGO:UBE2J1 HGNC:17598 ENTREZ:51465 UNIPROT:Q9Y385 GENECARDS:UBE2J1 REACTOME:155484 KEGG:51465 ATLASONC:GC_UBE2J1 WIKI:UBE2J1 ubiquitin-conjugating enzyme E2 J2 HUGO:UBE2J2 HGNC:19268 ENTREZ:118424 UNIPROT:Q8N2K1 GENECARDS:UBE2J2 REACTOME:155486 KEGG:118424 WIKI:UBE2J2 ubiquitin-conjugating enzyme E2K HUGO:UBE2K HGNC:4914 ENTREZ:3093 UNIPROT:P61086 GENECARDS:UBE2K REACTOME:66723 KEGG:3093 WIKI:UBE2K ubiquitin-conjugating enzyme E2L 3 HUGO:UBE2L3 HGNC:12488 ENTREZ:7332 UNIPROT:P68036 GENECARDS:UBE2L3 REACTOME:66741 KEGG:7332 ATLASONC:GC_UBE2L3 WIKI:UBE2L3 ubiquitin-conjugating enzyme E2L 4 HUGO:UBE2L4 HGNC:12489 ENTREZ:7333 GENECARDS:UBE2L4 WIKI:UBE2L4 ubiquitin-conjugating enzyme E2L 6 HUGO:UBE2L6 HGNC:12490 ENTREZ:9246 UNIPROT:O14933 GENECARDS:UBE2L6 REACTOME:66745 KEGG:9246 ATLASONC:GC_UBE2L6 WIKI:UBE2L6 ubiquitin-conjugating enzyme E2M HUGO:UBE2M HGNC:12491 ENTREZ:9040 UNIPROT:P61081 GENECARDS:UBE2M REACTOME:66777 KEGG:9040 ATLASONC:GC_UBE2M WIKI:UBE2M ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 GENECARDS:UBE2N REACTOME:66781 KEGG:7334 ATLASONC:GC_UBE2N WIKI:UBE2N ubiquitin-conjugating enzyme E2O HUGO:UBE2O HGNC:29554 ENTREZ:63893 UNIPROT:Q9C0C9 GENECARDS:UBE2O REACTOME:253534 KEGG:63893 ATLASONC:GC_UBE2O WIKI:UBE2O ubiquitin-conjugating enzyme E2Q family member 1 HUGO:UBE2Q1 HGNC:15698 ENTREZ:55585 UNIPROT:Q7Z7E8 GENECARDS:UBE2Q1 REACTOME:253474 KEGG:55585 ATLASONC:GC_UBE2Q1 WIKI:UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 2 HUGO:UBE2Q2 HGNC:19248 ENTREZ:92912 UNIPROT:Q8WVN8 GENECARDS:UBE2Q2 REACTOME:253479 ATLASONC:GC_UBE2Q2 WIKI:UBE2Q2 ubiquitin-conjugating enzyme E2R 2 HUGO:UBE2R2 HGNC:19907 ENTREZ:54926 UNIPROT:Q712K3 GENECARDS:UBE2R2 REACTOME:253483 KEGG:54926 ATLASONC:GC_UBE2R2 WIKI:UBE2R2 ubiquitin-conjugating enzyme E2S HUGO:UBE2S HGNC:17895 ENTREZ:27338 UNIPROT:Q16763 GENECARDS:UBE2S REACTOME:66751 KEGG:27338 ATLASONC:GC_UBE2S WIKI:UBE2S ubiquitin-conjugating enzyme E2Z HUGO:UBE2Z HGNC:25847 ENTREZ:65264 UNIPROT:Q9H832 GENECARDS:UBE2Z REACTOME:253545 KEGG:65264 WIKI:UBE2Z Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C ubiquitin-conjugating enzyme E2D 1 HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 ubiquitin-conjugating enzyme E2E 1 HUGO:UBE2E1 HGNC:12477 ENTREZ:7324 UNIPROT:P51965 GENECARDS:UBE2E1 REACTOME:66739 KEGG:7324 ATLASONC:GC_UBE2E1 WIKI:UBE2E1 ubiquitin-conjugating enzyme E2E 2 HUGO:UBE2E2 HGNC:12478 ENTREZ:7325 UNIPROT:Q96LR5 GENECARDS:UBE2E2 REACTOME:155471 KEGG:7325 ATLASONC:GC_UBE2E2 WIKI:UBE2E2 ubiquitin-conjugating enzyme E2G 1 HUGO:UBE2G1 HGNC:12482 ENTREZ:7326 UNIPROT:P62253 GENECARDS:UBE2G1 REACTOME:66753 KEGG:7326 ATLASONC:GC_UBE2G1 WIKI:UBE2G1 ubiquitin-conjugating enzyme E2G 2 HUGO:UBE2G2 HGNC:12483 ENTREZ:7327 UNIPROT:P60604 GENECARDS:UBE2G2 REACTOME:66773 KEGG:7327 ATLASONC:GC_UBE2G2 WIKI:UBE2G2 ubiquitin-conjugating enzyme E2H HUGO:UBE2H HGNC:12484 ENTREZ:7328 UNIPROT:P62256 GENECARDS:UBE2H REACTOME:66759 KEGG:7328 ATLASONC:GC_UBE2H WIKI:UBE2H ubiquitin-conjugating enzyme E2I HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I ubiquitin-conjugating enzyme E2 J1 HUGO:UBE2J1 HGNC:17598 ENTREZ:51465 UNIPROT:Q9Y385 GENECARDS:UBE2J1 REACTOME:155484 KEGG:51465 ATLASONC:GC_UBE2J1 WIKI:UBE2J1 ubiquitin-conjugating enzyme E2 J2 HUGO:UBE2J2 HGNC:19268 ENTREZ:118424 UNIPROT:Q8N2K1 GENECARDS:UBE2J2 REACTOME:155486 KEGG:118424 WIKI:UBE2J2 ubiquitin-conjugating enzyme E2K HUGO:UBE2K HGNC:4914 ENTREZ:3093 UNIPROT:P61086 GENECARDS:UBE2K REACTOME:66723 KEGG:3093 WIKI:UBE2K ubiquitin-conjugating enzyme E2L 3 HUGO:UBE2L3 HGNC:12488 ENTREZ:7332 UNIPROT:P68036 GENECARDS:UBE2L3 REACTOME:66741 KEGG:7332 ATLASONC:GC_UBE2L3 WIKI:UBE2L3 ubiquitin-conjugating enzyme E2L 4 HUGO:UBE2L4 HGNC:12489 ENTREZ:7333 GENECARDS:UBE2L4 WIKI:UBE2L4 ubiquitin-conjugating enzyme E2L 6 HUGO:UBE2L6 HGNC:12490 ENTREZ:9246 UNIPROT:O14933 GENECARDS:UBE2L6 REACTOME:66745 KEGG:9246 ATLASONC:GC_UBE2L6 WIKI:UBE2L6 ubiquitin-conjugating enzyme E2M HUGO:UBE2M HGNC:12491 ENTREZ:9040 UNIPROT:P61081 GENECARDS:UBE2M REACTOME:66777 KEGG:9040 ATLASONC:GC_UBE2M WIKI:UBE2M ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 GENECARDS:UBE2N REACTOME:66781 KEGG:7334 ATLASONC:GC_UBE2N WIKI:UBE2N ubiquitin-conjugating enzyme E2O HUGO:UBE2O HGNC:29554 ENTREZ:63893 UNIPROT:Q9C0C9 GENECARDS:UBE2O REACTOME:253534 KEGG:63893 ATLASONC:GC_UBE2O WIKI:UBE2O ubiquitin-conjugating enzyme E2Q family member 1 HUGO:UBE2Q1 HGNC:15698 ENTREZ:55585 UNIPROT:Q7Z7E8 GENECARDS:UBE2Q1 REACTOME:253474 KEGG:55585 ATLASONC:GC_UBE2Q1 WIKI:UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 2 HUGO:UBE2Q2 HGNC:19248 ENTREZ:92912 UNIPROT:Q8WVN8 GENECARDS:UBE2Q2 REACTOME:253479 ATLASONC:GC_UBE2Q2 WIKI:UBE2Q2 ubiquitin-conjugating enzyme E2R 2 HUGO:UBE2R2 HGNC:19907 ENTREZ:54926 UNIPROT:Q712K3 GENECARDS:UBE2R2 REACTOME:253483 KEGG:54926 ATLASONC:GC_UBE2R2 WIKI:UBE2R2 ubiquitin-conjugating enzyme E2S HUGO:UBE2S HGNC:17895 ENTREZ:27338 UNIPROT:Q16763 GENECARDS:UBE2S REACTOME:66751 KEGG:27338 ATLASONC:GC_UBE2S WIKI:UBE2S ubiquitin-conjugating enzyme E2Z HUGO:UBE2Z HGNC:25847 ENTREZ:65264 UNIPROT:Q9H832 GENECARDS:UBE2Z REACTOME:253545 KEGG:65264 WIKI:UBE2Z Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> </notes> <label text="E2*"/> <clone/> <bbox w="80.0" h="40.0" x="4652.5" y="2636.278"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s201_akt1_akt2_sa245" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C ubiquitin-conjugating enzyme E2D 1 HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 ubiquitin-conjugating enzyme E2E 1 HUGO:UBE2E1 HGNC:12477 ENTREZ:7324 UNIPROT:P51965 GENECARDS:UBE2E1 REACTOME:66739 KEGG:7324 ATLASONC:GC_UBE2E1 WIKI:UBE2E1 ubiquitin-conjugating enzyme E2E 2 HUGO:UBE2E2 HGNC:12478 ENTREZ:7325 UNIPROT:Q96LR5 GENECARDS:UBE2E2 REACTOME:155471 KEGG:7325 ATLASONC:GC_UBE2E2 WIKI:UBE2E2 ubiquitin-conjugating enzyme E2G 1 HUGO:UBE2G1 HGNC:12482 ENTREZ:7326 UNIPROT:P62253 GENECARDS:UBE2G1 REACTOME:66753 KEGG:7326 ATLASONC:GC_UBE2G1 WIKI:UBE2G1 ubiquitin-conjugating enzyme E2G 2 HUGO:UBE2G2 HGNC:12483 ENTREZ:7327 UNIPROT:P60604 GENECARDS:UBE2G2 REACTOME:66773 KEGG:7327 ATLASONC:GC_UBE2G2 WIKI:UBE2G2 ubiquitin-conjugating enzyme E2H HUGO:UBE2H HGNC:12484 ENTREZ:7328 UNIPROT:P62256 GENECARDS:UBE2H REACTOME:66759 KEGG:7328 ATLASONC:GC_UBE2H WIKI:UBE2H ubiquitin-conjugating enzyme E2I HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I ubiquitin-conjugating enzyme E2 J1 HUGO:UBE2J1 HGNC:17598 ENTREZ:51465 UNIPROT:Q9Y385 GENECARDS:UBE2J1 REACTOME:155484 KEGG:51465 ATLASONC:GC_UBE2J1 WIKI:UBE2J1 ubiquitin-conjugating enzyme E2 J2 HUGO:UBE2J2 HGNC:19268 ENTREZ:118424 UNIPROT:Q8N2K1 GENECARDS:UBE2J2 REACTOME:155486 KEGG:118424 WIKI:UBE2J2 ubiquitin-conjugating enzyme E2K HUGO:UBE2K HGNC:4914 ENTREZ:3093 UNIPROT:P61086 GENECARDS:UBE2K REACTOME:66723 KEGG:3093 WIKI:UBE2K ubiquitin-conjugating enzyme E2L 3 HUGO:UBE2L3 HGNC:12488 ENTREZ:7332 UNIPROT:P68036 GENECARDS:UBE2L3 REACTOME:66741 KEGG:7332 ATLASONC:GC_UBE2L3 WIKI:UBE2L3 ubiquitin-conjugating enzyme E2L 4 HUGO:UBE2L4 HGNC:12489 ENTREZ:7333 GENECARDS:UBE2L4 WIKI:UBE2L4 ubiquitin-conjugating enzyme E2L 6 HUGO:UBE2L6 HGNC:12490 ENTREZ:9246 UNIPROT:O14933 GENECARDS:UBE2L6 REACTOME:66745 KEGG:9246 ATLASONC:GC_UBE2L6 WIKI:UBE2L6 ubiquitin-conjugating enzyme E2M HUGO:UBE2M HGNC:12491 ENTREZ:9040 UNIPROT:P61081 GENECARDS:UBE2M REACTOME:66777 KEGG:9040 ATLASONC:GC_UBE2M WIKI:UBE2M ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 GENECARDS:UBE2N REACTOME:66781 KEGG:7334 ATLASONC:GC_UBE2N WIKI:UBE2N ubiquitin-conjugating enzyme E2O HUGO:UBE2O HGNC:29554 ENTREZ:63893 UNIPROT:Q9C0C9 GENECARDS:UBE2O REACTOME:253534 KEGG:63893 ATLASONC:GC_UBE2O WIKI:UBE2O ubiquitin-conjugating enzyme E2Q family member 1 HUGO:UBE2Q1 HGNC:15698 ENTREZ:55585 UNIPROT:Q7Z7E8 GENECARDS:UBE2Q1 REACTOME:253474 KEGG:55585 ATLASONC:GC_UBE2Q1 WIKI:UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 2 HUGO:UBE2Q2 HGNC:19248 ENTREZ:92912 UNIPROT:Q8WVN8 GENECARDS:UBE2Q2 REACTOME:253479 ATLASONC:GC_UBE2Q2 WIKI:UBE2Q2 ubiquitin-conjugating enzyme E2R 2 HUGO:UBE2R2 HGNC:19907 ENTREZ:54926 UNIPROT:Q712K3 GENECARDS:UBE2R2 REACTOME:253483 KEGG:54926 ATLASONC:GC_UBE2R2 WIKI:UBE2R2 ubiquitin-conjugating enzyme E2S HUGO:UBE2S HGNC:17895 ENTREZ:27338 UNIPROT:Q16763 GENECARDS:UBE2S REACTOME:66751 KEGG:27338 ATLASONC:GC_UBE2S WIKI:UBE2S ubiquitin-conjugating enzyme E2Z HUGO:UBE2Z HGNC:25847 ENTREZ:65264 UNIPROT:Q9H832 GENECARDS:UBE2Z REACTOME:253545 KEGG:65264 WIKI:UBE2Z Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C ubiquitin-conjugating enzyme E2D 1 HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 ubiquitin-conjugating enzyme E2E 1 HUGO:UBE2E1 HGNC:12477 ENTREZ:7324 UNIPROT:P51965 GENECARDS:UBE2E1 REACTOME:66739 KEGG:7324 ATLASONC:GC_UBE2E1 WIKI:UBE2E1 ubiquitin-conjugating enzyme E2E 2 HUGO:UBE2E2 HGNC:12478 ENTREZ:7325 UNIPROT:Q96LR5 GENECARDS:UBE2E2 REACTOME:155471 KEGG:7325 ATLASONC:GC_UBE2E2 WIKI:UBE2E2 ubiquitin-conjugating enzyme E2G 1 HUGO:UBE2G1 HGNC:12482 ENTREZ:7326 UNIPROT:P62253 GENECARDS:UBE2G1 REACTOME:66753 KEGG:7326 ATLASONC:GC_UBE2G1 WIKI:UBE2G1 ubiquitin-conjugating enzyme E2G 2 HUGO:UBE2G2 HGNC:12483 ENTREZ:7327 UNIPROT:P60604 GENECARDS:UBE2G2 REACTOME:66773 KEGG:7327 ATLASONC:GC_UBE2G2 WIKI:UBE2G2 ubiquitin-conjugating enzyme E2H HUGO:UBE2H HGNC:12484 ENTREZ:7328 UNIPROT:P62256 GENECARDS:UBE2H REACTOME:66759 KEGG:7328 ATLASONC:GC_UBE2H WIKI:UBE2H ubiquitin-conjugating enzyme E2I HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I ubiquitin-conjugating enzyme E2 J1 HUGO:UBE2J1 HGNC:17598 ENTREZ:51465 UNIPROT:Q9Y385 GENECARDS:UBE2J1 REACTOME:155484 KEGG:51465 ATLASONC:GC_UBE2J1 WIKI:UBE2J1 ubiquitin-conjugating enzyme E2 J2 HUGO:UBE2J2 HGNC:19268 ENTREZ:118424 UNIPROT:Q8N2K1 GENECARDS:UBE2J2 REACTOME:155486 KEGG:118424 WIKI:UBE2J2 ubiquitin-conjugating enzyme E2K HUGO:UBE2K HGNC:4914 ENTREZ:3093 UNIPROT:P61086 GENECARDS:UBE2K REACTOME:66723 KEGG:3093 WIKI:UBE2K ubiquitin-conjugating enzyme E2L 3 HUGO:UBE2L3 HGNC:12488 ENTREZ:7332 UNIPROT:P68036 GENECARDS:UBE2L3 REACTOME:66741 KEGG:7332 ATLASONC:GC_UBE2L3 WIKI:UBE2L3 ubiquitin-conjugating enzyme E2L 4 HUGO:UBE2L4 HGNC:12489 ENTREZ:7333 GENECARDS:UBE2L4 WIKI:UBE2L4 ubiquitin-conjugating enzyme E2L 6 HUGO:UBE2L6 HGNC:12490 ENTREZ:9246 UNIPROT:O14933 GENECARDS:UBE2L6 REACTOME:66745 KEGG:9246 ATLASONC:GC_UBE2L6 WIKI:UBE2L6 ubiquitin-conjugating enzyme E2M HUGO:UBE2M HGNC:12491 ENTREZ:9040 UNIPROT:P61081 GENECARDS:UBE2M REACTOME:66777 KEGG:9040 ATLASONC:GC_UBE2M WIKI:UBE2M ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 GENECARDS:UBE2N REACTOME:66781 KEGG:7334 ATLASONC:GC_UBE2N WIKI:UBE2N ubiquitin-conjugating enzyme E2O HUGO:UBE2O HGNC:29554 ENTREZ:63893 UNIPROT:Q9C0C9 GENECARDS:UBE2O REACTOME:253534 KEGG:63893 ATLASONC:GC_UBE2O WIKI:UBE2O ubiquitin-conjugating enzyme E2Q family member 1 HUGO:UBE2Q1 HGNC:15698 ENTREZ:55585 UNIPROT:Q7Z7E8 GENECARDS:UBE2Q1 REACTOME:253474 KEGG:55585 ATLASONC:GC_UBE2Q1 WIKI:UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 2 HUGO:UBE2Q2 HGNC:19248 ENTREZ:92912 UNIPROT:Q8WVN8 GENECARDS:UBE2Q2 REACTOME:253479 ATLASONC:GC_UBE2Q2 WIKI:UBE2Q2 ubiquitin-conjugating enzyme E2R 2 HUGO:UBE2R2 HGNC:19907 ENTREZ:54926 UNIPROT:Q712K3 GENECARDS:UBE2R2 REACTOME:253483 KEGG:54926 ATLASONC:GC_UBE2R2 WIKI:UBE2R2 ubiquitin-conjugating enzyme E2S HUGO:UBE2S HGNC:17895 ENTREZ:27338 UNIPROT:Q16763 GENECARDS:UBE2S REACTOME:66751 KEGG:27338 ATLASONC:GC_UBE2S WIKI:UBE2S ubiquitin-conjugating enzyme E2Z HUGO:UBE2Z HGNC:25847 ENTREZ:65264 UNIPROT:Q9H832 GENECARDS:UBE2Z REACTOME:253545 KEGG:65264 WIKI:UBE2Z Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C ubiquitin-conjugating enzyme E2D 1 HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 ubiquitin-conjugating enzyme E2E 1 HUGO:UBE2E1 HGNC:12477 ENTREZ:7324 UNIPROT:P51965 GENECARDS:UBE2E1 REACTOME:66739 KEGG:7324 ATLASONC:GC_UBE2E1 WIKI:UBE2E1 ubiquitin-conjugating enzyme E2E 2 HUGO:UBE2E2 HGNC:12478 ENTREZ:7325 UNIPROT:Q96LR5 GENECARDS:UBE2E2 REACTOME:155471 KEGG:7325 ATLASONC:GC_UBE2E2 WIKI:UBE2E2 ubiquitin-conjugating enzyme E2G 1 HUGO:UBE2G1 HGNC:12482 ENTREZ:7326 UNIPROT:P62253 GENECARDS:UBE2G1 REACTOME:66753 KEGG:7326 ATLASONC:GC_UBE2G1 WIKI:UBE2G1 ubiquitin-conjugating enzyme E2G 2 HUGO:UBE2G2 HGNC:12483 ENTREZ:7327 UNIPROT:P60604 GENECARDS:UBE2G2 REACTOME:66773 KEGG:7327 ATLASONC:GC_UBE2G2 WIKI:UBE2G2 ubiquitin-conjugating enzyme E2H HUGO:UBE2H HGNC:12484 ENTREZ:7328 UNIPROT:P62256 GENECARDS:UBE2H REACTOME:66759 KEGG:7328 ATLASONC:GC_UBE2H WIKI:UBE2H ubiquitin-conjugating enzyme E2I HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I ubiquitin-conjugating enzyme E2 J1 HUGO:UBE2J1 HGNC:17598 ENTREZ:51465 UNIPROT:Q9Y385 GENECARDS:UBE2J1 REACTOME:155484 KEGG:51465 ATLASONC:GC_UBE2J1 WIKI:UBE2J1 ubiquitin-conjugating enzyme E2 J2 HUGO:UBE2J2 HGNC:19268 ENTREZ:118424 UNIPROT:Q8N2K1 GENECARDS:UBE2J2 REACTOME:155486 KEGG:118424 WIKI:UBE2J2 ubiquitin-conjugating enzyme E2K HUGO:UBE2K HGNC:4914 ENTREZ:3093 UNIPROT:P61086 GENECARDS:UBE2K REACTOME:66723 KEGG:3093 WIKI:UBE2K ubiquitin-conjugating enzyme E2L 3 HUGO:UBE2L3 HGNC:12488 ENTREZ:7332 UNIPROT:P68036 GENECARDS:UBE2L3 REACTOME:66741 KEGG:7332 ATLASONC:GC_UBE2L3 WIKI:UBE2L3 ubiquitin-conjugating enzyme E2L 4 HUGO:UBE2L4 HGNC:12489 ENTREZ:7333 GENECARDS:UBE2L4 WIKI:UBE2L4 ubiquitin-conjugating enzyme E2L 6 HUGO:UBE2L6 HGNC:12490 ENTREZ:9246 UNIPROT:O14933 GENECARDS:UBE2L6 REACTOME:66745 KEGG:9246 ATLASONC:GC_UBE2L6 WIKI:UBE2L6 ubiquitin-conjugating enzyme E2M HUGO:UBE2M HGNC:12491 ENTREZ:9040 UNIPROT:P61081 GENECARDS:UBE2M REACTOME:66777 KEGG:9040 ATLASONC:GC_UBE2M WIKI:UBE2M ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 GENECARDS:UBE2N REACTOME:66781 KEGG:7334 ATLASONC:GC_UBE2N WIKI:UBE2N ubiquitin-conjugating enzyme E2O HUGO:UBE2O HGNC:29554 ENTREZ:63893 UNIPROT:Q9C0C9 GENECARDS:UBE2O REACTOME:253534 KEGG:63893 ATLASONC:GC_UBE2O WIKI:UBE2O ubiquitin-conjugating enzyme E2Q family member 1 HUGO:UBE2Q1 HGNC:15698 ENTREZ:55585 UNIPROT:Q7Z7E8 GENECARDS:UBE2Q1 REACTOME:253474 KEGG:55585 ATLASONC:GC_UBE2Q1 WIKI:UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 2 HUGO:UBE2Q2 HGNC:19248 ENTREZ:92912 UNIPROT:Q8WVN8 GENECARDS:UBE2Q2 REACTOME:253479 ATLASONC:GC_UBE2Q2 WIKI:UBE2Q2 ubiquitin-conjugating enzyme E2R 2 HUGO:UBE2R2 HGNC:19907 ENTREZ:54926 UNIPROT:Q712K3 GENECARDS:UBE2R2 REACTOME:253483 KEGG:54926 ATLASONC:GC_UBE2R2 WIKI:UBE2R2 ubiquitin-conjugating enzyme E2S HUGO:UBE2S HGNC:17895 ENTREZ:27338 UNIPROT:Q16763 GENECARDS:UBE2S REACTOME:66751 KEGG:27338 ATLASONC:GC_UBE2S WIKI:UBE2S ubiquitin-conjugating enzyme E2Z HUGO:UBE2Z HGNC:25847 ENTREZ:65264 UNIPROT:Q9H832 GENECARDS:UBE2Z REACTOME:253545 KEGG:65264 WIKI:UBE2Z Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> </notes> <label text="E2*"/> <clone/> <bbox w="80.0" h="40.0" x="4864.625" y="4995.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s202_akt1_akt2_sa159" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re75:(MAP:survival) PMID:19321440 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 GENECARDS:FOXO3 REACTOME:199273 KEGG:2309 ATLASONC:AF6q21ID125 WIKI:FOXO3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16288288 PMID:17646672 References_end</body> </html> </notes> <label text="FOXO3"/> <bbox w="80.0" h="40.0" x="4432.25" y="2802.0"/> <glyph class="state variable" id="_0e43beb3-2b1a-48ee-80b5-8986e56d3b43"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="4462.25" y="2797.0"/> </glyph> <glyph class="state variable" id="_da35f002-0eea-44eb-aeb9-c49ece963936"> <state value="" variable="S644"/> <bbox w="30.0" h="10.0" x="4417.25" y="2836.7224"/> </glyph> <glyph class="state variable" id="_c03e0a2b-ebbf-4152-b465-19e2dd15ed50"> <state value="" variable="T32"/> <bbox w="25.0" h="10.0" x="4419.75" y="2797.9302"/> </glyph> <glyph class="state variable" id="_6df7ba71-6fcc-4e48-9e9b-fd4426022dd3"> <state value="" variable="S253"/> <bbox w="30.0" h="10.0" x="4497.25" y="2836.1306"/> </glyph> <glyph class="state variable" id="_0f14ba3c-433d-4b61-827f-b5ad865139e4"> <state value="" variable="S315"/> <bbox w="30.0" h="10.0" x="4493.832" y="2797.0"/> </glyph> <glyph class="state variable" id="_8244fda9-c64f-49f2-aecf-25041e1a872a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4427.25" y="2817.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s203_akt1_akt2_sa160" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re77(MAP:survival): PMID:10721693 PMID:19459846 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 References_end Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end</body> </html> </notes> <label text="p53*"/> <bbox w="80.0" h="40.0" x="6083.5" y="4265.0"/> <glyph class="state variable" id="_deee40c3-4dd0-4a3e-ad6f-7169da0913d2"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="6153.5" y="4300.0"/> </glyph> <glyph class="state variable" id="_6b976f71-0d02-4d1a-adcc-28c6618d7411"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="6073.5" y="4260.0"/> </glyph> <glyph class="state variable" id="_62d1c9cf-6ee3-4854-90b3-889f04331bcd"> <state value="" variable="S46"/> <bbox w="25.0" h="10.0" x="6151.0" y="4260.215"/> </glyph> <glyph class="state variable" id="_cbd03fa3-eecd-4403-afad-4abaaf5e0f7d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6078.5" y="4280.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s210_akt1_akt2_sa166" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re82:(MAP:survival) PMID15084260 s_akt2_re83:(MAP:survival) PMID:15084260 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 GENECARDS:FOXO3 REACTOME:199273 KEGG:2309 ATLASONC:AF6q21ID125 WIKI:FOXO3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16288288 PMID:17646672 References_end</body> </html> </notes> <label text="FOXO3"/> <bbox w="80.0" h="40.0" x="4894.25" y="3240.0"/> <glyph class="state variable" id="_0fbf706d-085c-4409-94f8-e0c98ecd02f8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4929.25" y="3235.0"/> </glyph> <glyph class="state variable" id="_966c50f3-96b8-4c86-b85b-410b408a8586"> <state value="P" variable="S644"/> <bbox w="35.0" h="10.0" x="4876.75" y="3274.7224"/> </glyph> <glyph class="state variable" id="_a4bcf448-4372-4f9b-9d1c-3ebf8ee2b7b9"> <state value="" variable="T32"/> <bbox w="25.0" h="10.0" x="4881.75" y="3235.9302"/> </glyph> <glyph class="state variable" id="_07cb6f39-7c82-4635-a548-b6ef33159314"> <state value="" variable="S253"/> <bbox w="30.0" h="10.0" x="4959.25" y="3274.1306"/> </glyph> <glyph class="state variable" id="_d2278bc7-38d7-4954-8642-eb306afc15ad"> <state value="" variable="S315"/> <bbox w="30.0" h="10.0" x="4955.832" y="3235.0"/> </glyph> <glyph class="state variable" id="_106871f2-9990-4ab7-9c07-f61d867cefe4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4889.25" y="3255.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s211_akt1_akt2_sa167" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re83:(MAP:survival) PMID:15084260 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 GENECARDS:FOXO3 REACTOME:199273 KEGG:2309 ATLASONC:AF6q21ID125 WIKI:FOXO3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16288288 PMID:17646672 References_end</body> </html> </notes> <label text="FOXO3"/> <bbox w="80.0" h="40.0" x="4986.25" y="2727.6736"/> <glyph class="state variable" id="_ee91c12b-f9fa-450f-89a6-339af36d7768"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5021.25" y="2722.6736"/> </glyph> <glyph class="state variable" id="_c6d571b2-9719-4e60-92e0-6cc65fbb3ce8"> <state value="P" variable="S644"/> <bbox w="35.0" h="10.0" x="4968.75" y="2762.396"/> </glyph> <glyph class="state variable" id="_75de2990-8883-476d-9391-5c2ac308f605"> <state value="" variable="T32"/> <bbox w="25.0" h="10.0" x="4973.75" y="2723.6038"/> </glyph> <glyph class="state variable" id="_1f30ba0e-9148-4d7c-b0e5-9eac2c2c6d1b"> <state value="" variable="S253"/> <bbox w="30.0" h="10.0" x="5051.25" y="2761.8042"/> </glyph> <glyph class="state variable" id="_a9a35bcc-7e03-4015-96e9-56be119286b0"> <state value="" variable="S315"/> <bbox w="30.0" h="10.0" x="5047.832" y="2722.6736"/> </glyph> <glyph class="state variable" id="_109d478b-f785-4a03-bdde-aba4f5e904a0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4981.25" y="2742.6736"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s213_akt1_akt2_sa169" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re80:(MAP:survival) PMID15084260 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: conserved helix HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK inhibitor of kappa light polypeptide gene enhancer in B-cells kinase beta HUGO:IKBKB HGNC:5960 ENTREZ:3551 UNIPROT:O14920 GENECARDS:IKBKB REACTOME:57216 KEGG:3551 ATLASONC:GC_IKBKB WIKI:IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells kinase epsilon HUGO:IKBKE HGNC:14552 ENTREZ:9641 UNIPROT:Q14164 GENECARDS:IKBKE REACTOME:57218 KEGG:9641 ATLASONC:GC_IKBKE WIKI:IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells kinase gamma HUGO:IKBKG HGNC:5961 ENTREZ:8517 UNIPROT:Q9Y6K9 GENECARDS:IKBKG REACTOME:60067 KEGG:8517 ATLASONC:GC_IKBKG WIKI:IKBKG Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20300203 PMID:15084260 References_end</body> </html> </notes> <label text="IKK*"/> <bbox w="80.0" h="40.0" x="4920.0" y="3170.5"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s216_akt1_akt2_sa172" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re61(MAP:survival): PMID15509806 PMID20673124 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL6 corepressor HUGO:BCOR HGNC:20893 ENTREZ:54880 UNIPROT:Q6W2J9 GENECARDS:BCOR KEGG:54880 ATLASONC:GC_BCOR WIKI:BCOR Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15509806 References_end</body> </html> </notes> <label text="BCL6*"/> <bbox w="80.0" h="40.0" x="5196.0" y="3616.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s217_akt1_akt2_sa35" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end</body> </html> </notes> <label text="PTEN"/> <bbox w="80.0" h="40.0" x="6754.5" y="3791.0"/> <glyph class="state variable" id="_0985f66e-d396-49a8-b108-231d2e22eeea"> <state value="" variable="S380"/> <bbox w="30.0" h="10.0" x="6789.7476" y="3786.0"/> </glyph> <glyph class="state variable" id="_b5d337b6-94f9-4c9f-ac25-f8d372bbd280"> <state value="" variable="S370"/> <bbox w="30.0" h="10.0" x="6819.1333" y="3786.0"/> </glyph> <glyph class="state variable" id="_27ecae5d-ccdc-4b9c-ae99-c870241e708a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6829.5" y="3826.0"/> </glyph> <glyph class="state variable" id="_f3fb7ba9-1122-4f4a-a2e0-8804feccd74f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6749.5" y="3826.0"/> </glyph> <glyph class="state variable" id="_cc818fe5-c7ec-4023-ba0f-33ea26738d77"> <state value="" variable="K289"/> <bbox w="30.0" h="10.0" x="6780.2046" y="3826.0"/> </glyph> <glyph class="state variable" id="_dcb0c8b4-afe3-422f-9495-98aefa6ed56f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6749.5" y="3786.0"/> </glyph> <glyph class="state variable" id="_da8b466f-99d5-4763-8f81-f5856be2c9a7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6829.5" y="3786.0"/> </glyph> <glyph class="state variable" id="_87f3708c-9fcd-4a91-926a-7218955f2b58"> <state value="" variable="K13"/> <bbox w="25.0" h="10.0" x="6742.24" y="3826.0"/> </glyph> <glyph class="state variable" id="_ea6d2e51-9bde-4d54-a5f6-81e55c4a092f"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="6739.5" y="3805.9683"/> </glyph> <glyph class="state variable" id="_7bcfe667-c8e3-41a1-9551-cf3650416726"> <state value="" variable="T366"/> <bbox w="30.0" h="10.0" x="6819.5" y="3806.0"/> </glyph> <glyph class="state variable" id="_b82dc066-9502-4514-88be-824edae5d6d2"> <state value="" variable="T383"/> <bbox w="30.0" h="10.0" x="6739.5" y="3788.402"/> </glyph> <glyph class="state variable" id="_50ab81be-38a3-444a-963e-6cffa24dd395"> <state value="" variable="T382"/> <bbox w="30.0" h="10.0" x="6768.032" y="3786.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s218_akt1_akt2_sa34" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end</body> </html> </notes> <label text="PTEN"/> <bbox w="80.0" h="40.0" x="6754.5" y="3855.0"/> <glyph class="state variable" id="_964db487-0682-4d5a-8f8c-065f17deb32a"> <state value="" variable="S380"/> <bbox w="30.0" h="10.0" x="6789.7476" y="3850.0"/> </glyph> <glyph class="state variable" id="_bed42735-a55a-4c7b-967e-d88bd5f1c124"> <state value="" variable="S370"/> <bbox w="30.0" h="10.0" x="6819.1333" y="3850.0"/> </glyph> <glyph class="state variable" id="_66b2a6df-a0e5-4839-9860-5846b656b1dd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6829.5" y="3890.0"/> </glyph> <glyph class="state variable" id="_89ddf513-69f9-4473-9b87-7f4182e54a52"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6749.5" y="3890.0"/> </glyph> <glyph class="state variable" id="_6f608be7-2a18-461a-91df-47dba7a18207"> <state value="" variable="K289"/> <bbox w="30.0" h="10.0" x="6780.2046" y="3890.0"/> </glyph> <glyph class="state variable" id="_7275edfa-e1c3-4cdc-8ae6-98e9e6315d22"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6749.5" y="3850.0"/> </glyph> <glyph class="state variable" id="_b6029150-399c-46be-b741-1979ca5a57c5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6829.5" y="3850.0"/> </glyph> <glyph class="state variable" id="_4335c598-f9e6-4f9e-af19-00132f98b9f0"> <state value="" variable="K13"/> <bbox w="25.0" h="10.0" x="6742.24" y="3890.0"/> </glyph> <glyph class="state variable" id="_0e2bc6a0-d3e9-4367-ac07-b0d814c33825"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="6739.5" y="3869.9683"/> </glyph> <glyph class="state variable" id="_4362f78f-aeb7-4925-8537-bff457587504"> <state value="" variable="T366"/> <bbox w="30.0" h="10.0" x="6819.5" y="3870.0"/> </glyph> <glyph class="state variable" id="_8aef2a2a-d8a0-404a-92bd-68caa134e810"> <state value="" variable="T383"/> <bbox w="30.0" h="10.0" x="6739.5" y="3852.402"/> </glyph> <glyph class="state variable" id="_911eed29-b279-48fb-9300-b075e1576094"> <state value="" variable="T382"/> <bbox w="30.0" h="10.0" x="6768.032" y="3850.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s219_akt1_akt2_sa38" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end</body> </html> </notes> <label text="PTEN"/> <bbox w="80.0" h="40.0" x="6754.5" y="3936.0"/> <glyph class="state variable" id="_563e6670-3131-4a5c-8dec-4d7d45be0319"> <state value="" variable="S380"/> <bbox w="30.0" h="10.0" x="6789.7476" y="3931.0"/> </glyph> <glyph class="state variable" id="_eaedacc2-a908-4e3c-b83b-9d469ec88aed"> <state value="" variable="S370"/> <bbox w="30.0" h="10.0" x="6819.1333" y="3931.0"/> </glyph> <glyph class="state variable" id="_caaa726a-105a-43a2-8905-6433a2090c85"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6829.5" y="3971.0"/> </glyph> <glyph class="state variable" id="_0597b563-ff9e-4b84-84e1-196bebb05fc8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6749.5" y="3971.0"/> </glyph> <glyph class="state variable" id="_595d0025-8bf4-4ea2-8b8e-c359a3f3f571"> <state value="" variable="K289"/> <bbox w="30.0" h="10.0" x="6780.2046" y="3971.0"/> </glyph> <glyph class="state variable" id="_b08c2948-bd76-494b-8192-d0f626dfbcc1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6749.5" y="3931.0"/> </glyph> <glyph class="state variable" id="_40288cfd-7d24-4099-b097-d3840c2ab320"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6829.5" y="3931.0"/> </glyph> <glyph class="state variable" id="_e2dc2446-6f2f-434e-b97d-43b975411e44"> <state value="" variable="K13"/> <bbox w="25.0" h="10.0" x="6742.24" y="3971.0"/> </glyph> <glyph class="state variable" id="_e3764c00-8e2f-49de-982f-28c531c0251d"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="6739.5" y="3950.9683"/> </glyph> <glyph class="state variable" id="_3c62af68-7c07-474d-94c7-9492ad913ce3"> <state value="" variable="T366"/> <bbox w="30.0" h="10.0" x="6819.5" y="3951.0"/> </glyph> <glyph class="state variable" id="_73edb110-dc0a-4db1-a840-6764a0808c5c"> <state value="" variable="T383"/> <bbox w="30.0" h="10.0" x="6739.5" y="3933.402"/> </glyph> <glyph class="state variable" id="_0c87f4f6-bac0-4a7d-a413-ce2eb13b3837"> <state value="" variable="T382"/> <bbox w="30.0" h="10.0" x="6768.032" y="3931.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s265_akt1_akt2_sa213" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re110:(MAP:survival) PMID:11313479 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O4 HUGO:FOXO4 HGNC:7139 ENTREZ:4303 UNIPROT:P98177 GENECARDS:FOXO4 REACTOME:404982 KEGG:4303 ATLASONC:AFX1ID57 WIKI:FOXO4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11313479 PMID:10217147 PMID:12391153 References_end</body> </html> </notes> <label text="FOXO4"/> <bbox w="80.0" h="40.0" x="4410.5" y="3547.0"/> <glyph class="state variable" id="_938f77bc-25a7-4ec0-971e-7f539a274d4a"> <state value="" variable="S193"/> <bbox w="30.0" h="10.0" x="4475.5" y="3542.2148"/> </glyph> <glyph class="state variable" id="_d74fa5b6-c505-4d15-9c34-183d4a675741"> <state value="" variable="S258"/> <bbox w="30.0" h="10.0" x="4474.882" y="3582.0"/> </glyph> <glyph class="state variable" id="_7a15934f-fc7b-4c35-8af1-4deaf1bf3929"> <state value="" variable="T28"/> <bbox w="25.0" h="10.0" x="4398.4927" y="3542.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s268_akt1_akt2_sa214" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re114:(MAP:survival) PMID:11313479 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: importin 4 HUGO:IPO4 HGNC:19426 ENTREZ:79711 UNIPROT:Q8TEX9 GENECARDS:IPO4 KEGG:79711 ATLASONC:GC_IPO4 WIKI:IPO4 importin 5 HUGO:IPO5 HGNC:6402 ENTREZ:3843 UNIPROT:O00410 GENECARDS:IPO5 REACTOME:57347 KEGG:3843 ATLASONC:GC_IPO5 WIKI:IPO5 importin 7 HUGO:IPO7 HGNC:9852 ENTREZ:10527 UNIPROT:O95373 GENECARDS:IPO7 KEGG:10527 ATLASONC:GC_IPO7 WIKI:IPO7 importin 8 HUGO:IPO8 HGNC:9853 ENTREZ:10526 UNIPROT:O15397 GENECARDS:IPO8 KEGG:10526 ATLASONC:GC_IPO8 WIKI:IPO8 importin 9 HUGO:IPO9 HGNC:19425 ENTREZ:55705 UNIPROT:Q96P70 GENECARDS:IPO9 KEGG:55705 WIKI:IPO9 importin 11 HUGO:IPO11 HGNC:20628 ENTREZ:51194 UNIPROT:Q9UI26 GENECARDS:IPO11 KEGG:51194 ATLASONC:GC_IPO11 WIKI:IPO11 importin 13 HUGO:IPO13 HGNC:16853 ENTREZ:9670 UNIPROT:O94829 GENECARDS:IPO13 KEGG:9670 ATLASONC:GC_IPO13 WIKI:IPO13 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11313479 PMID:10217147 PMID:12391153 References_end</body> </html> </notes> <label text="IMPORTIN*"/> <bbox w="80.0" h="40.0" x="4465.0" y="3458.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s273_akt1_akt2_sa218" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re112:(MAP:survival) PMID:11313479 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: importin 4 HUGO:IPO4 HGNC:19426 ENTREZ:79711 UNIPROT:Q8TEX9 GENECARDS:IPO4 KEGG:79711 ATLASONC:GC_IPO4 WIKI:IPO4 importin 5 HUGO:IPO5 HGNC:6402 ENTREZ:3843 UNIPROT:O00410 GENECARDS:IPO5 REACTOME:57347 KEGG:3843 ATLASONC:GC_IPO5 WIKI:IPO5 importin 7 HUGO:IPO7 HGNC:9852 ENTREZ:10527 UNIPROT:O95373 GENECARDS:IPO7 KEGG:10527 ATLASONC:GC_IPO7 WIKI:IPO7 importin 8 HUGO:IPO8 HGNC:9853 ENTREZ:10526 UNIPROT:O15397 GENECARDS:IPO8 KEGG:10526 ATLASONC:GC_IPO8 WIKI:IPO8 importin 9 HUGO:IPO9 HGNC:19425 ENTREZ:55705 UNIPROT:Q96P70 GENECARDS:IPO9 KEGG:55705 WIKI:IPO9 importin 11 HUGO:IPO11 HGNC:20628 ENTREZ:51194 UNIPROT:Q9UI26 GENECARDS:IPO11 KEGG:51194 ATLASONC:GC_IPO11 WIKI:IPO11 importin 13 HUGO:IPO13 HGNC:16853 ENTREZ:9670 UNIPROT:O94829 GENECARDS:IPO13 KEGG:9670 ATLASONC:GC_IPO13 WIKI:IPO13 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11313479 PMID:10217147 PMID:12391153 References_end</body> </html> </notes> <label text="IMPORTIN*"/> <bbox w="80.0" h="40.0" x="4693.125" y="3652.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s276_akt1_akt2_sa219" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re113:(MAP:survival) PMID:10217147 s_akt2_re115:(MAP:survival) PMID:11313479 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O4 HUGO:FOXO4 HGNC:7139 ENTREZ:4303 UNIPROT:P98177 GENECARDS:FOXO4 REACTOME:404982 KEGG:4303 ATLASONC:AFX1ID57 WIKI:FOXO4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11313479 PMID:10217147 PMID:12391153 References_end</body> </html> </notes> <label text="FOXO4"/> <bbox w="80.0" h="40.0" x="4921.5" y="3870.0"/> <glyph class="state variable" id="_85658a07-6698-43a4-b115-5462112e275d"> <state value="P" variable="S193"/> <bbox w="35.0" h="10.0" x="4984.0" y="3865.2148"/> </glyph> <glyph class="state variable" id="_c7402b75-cc45-4b51-ade2-8275ea4d60bc"> <state value="P" variable="S258"/> <bbox w="35.0" h="10.0" x="4983.382" y="3905.0"/> </glyph> <glyph class="state variable" id="_f17fe752-c4aa-4fdf-8f3b-916aae90ee59"> <state value="P" variable="T28"/> <bbox w="30.0" h="10.0" x="4906.9927" y="3865.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s283_akt1_akt2_sa227" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: forkhead box O4 HUGO:FOXO4 HGNC:7139 ENTREZ:4303 UNIPROT:P98177 GENECARDS:FOXO4 REACTOME:404982 KEGG:4303 ATLASONC:AFX1ID57 WIKI:FOXO4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11313479 PMID:10217147 PMID:12391153 References_end</body> </html> </notes> <label text="FOXO4"/> <bbox w="80.0" h="40.0" x="4541.5" y="4048.0"/> <glyph class="state variable" id="_7b4d52fb-9769-45d7-a562-dbbf42c60767"> <state value="P" variable="S193"/> <bbox w="35.0" h="10.0" x="4604.0" y="4043.2148"/> </glyph> <glyph class="state variable" id="_41b9059c-a2b9-406d-a0f3-9044fd9cf122"> <state value="P" variable="S258"/> <bbox w="35.0" h="10.0" x="4603.382" y="4083.0"/> </glyph> <glyph class="state variable" id="_7792eee5-3d14-417e-86d5-ef7595664251"> <state value="P" variable="T28"/> <bbox w="30.0" h="10.0" x="4526.9927" y="4043.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s300_akt1_akt2_sa204" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re104:(MAP:survival) PMID:15668399 s_akt2_re159:(MAP:survival) PMID:17646672 s_akt2_re118:(MAP:survival) PMID:14664696 s_akt2_re121:(MAP:survival) PMID:11980723 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end</body> </html> </notes> <label text="FOXO1"/> <bbox w="80.0" h="40.0" x="4831.25" y="4011.0"/> <glyph class="state variable" id="_720953aa-d014-4608-9d59-61e1b7a37d85"> <state value="" variable="S329"/> <bbox w="30.0" h="10.0" x="4816.25" y="4045.7224"/> </glyph> <glyph class="state variable" id="_2c8b6c60-7cfe-4a56-8d07-cc8584b2c69f"> <state value="P" variable="S319"/> <bbox w="35.0" h="10.0" x="4893.75" y="4006.0"/> </glyph> <glyph class="state variable" id="_3dcd5a4d-21d8-4307-a04c-ce198b1d5d0d"> <state value="" variable="S325"/> <bbox w="30.0" h="10.0" x="4856.1543" y="4046.0"/> </glyph> <glyph class="state variable" id="_e39a4e08-37c7-47c9-9b11-9de8ef93dd3f"> <state value="" variable="S322"/> <bbox w="30.0" h="10.0" x="4895.632" y="4046.0"/> </glyph> <glyph class="state variable" id="_1a1ec21a-4353-4495-86ee-c6f889a2277a"> <state value="P" variable="S256"/> <bbox w="35.0" h="10.0" x="4853.7817" y="4006.0"/> </glyph> <glyph class="state variable" id="_ffe07b15-f346-4ba9-8b0c-2031e15028a9"> <state value="P" variable="T24"/> <bbox w="30.0" h="10.0" x="4816.7427" y="4006.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s303_akt1_akt2_sa182" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re120:(MAP:survival) PMID:14664696 s_akt2_re125:(MAP:survival) PMID:11980723 PMID:14664696 s_akt2_re91:(MAP:survival) PMID:15668399 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end</body> </html> </notes> <label text="FOXO1"/> <bbox w="80.0" h="40.0" x="4435.25" y="4877.0"/> <glyph class="state variable" id="_340e4915-b39f-4752-88da-af91915ee01c"> <state value="" variable="S329"/> <bbox w="30.0" h="10.0" x="4420.25" y="4911.722"/> </glyph> <glyph class="state variable" id="_d8600cd4-420d-4b83-8e98-62521c78bb35"> <state value="P" variable="S319"/> <bbox w="35.0" h="10.0" x="4497.75" y="4872.0"/> </glyph> <glyph class="state variable" id="_35d6be25-9e88-46f6-a286-caa541d81c1a"> <state value="" variable="S325"/> <bbox w="30.0" h="10.0" x="4460.1543" y="4912.0"/> </glyph> <glyph class="state variable" id="_0e8ce1da-a9dd-4638-b3ba-194a4b76d845"> <state value="" variable="S322"/> <bbox w="30.0" h="10.0" x="4499.632" y="4912.0"/> </glyph> <glyph class="state variable" id="_8956dd0b-5eb5-47e3-9c96-0a3a38614fd3"> <state value="P" variable="S256"/> <bbox w="35.0" h="10.0" x="4457.7817" y="4872.0"/> </glyph> <glyph class="state variable" id="_41984101-984d-4caa-944e-54239634b20b"> <state value="P" variable="T24"/> <bbox w="30.0" h="10.0" x="4420.7427" y="4872.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s304_akt1_akt2_sa183" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re91:(MAP:survival) PMID:15668399 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end</body> </html> </notes> <label text="FOXO1"/> <bbox w="80.0" h="40.0" x="4435.25" y="4979.0"/> <glyph class="state variable" id="_67b2f3dd-6810-4cb1-818c-baf44cf0bddd"> <state value="" variable="S329"/> <bbox w="30.0" h="10.0" x="4420.25" y="5013.722"/> </glyph> <glyph class="state variable" id="_0a3a693e-d87e-4e03-9fc3-7c8fa3cb9777"> <state value="P" variable="S319"/> <bbox w="35.0" h="10.0" x="4497.75" y="4974.0"/> </glyph> <glyph class="state variable" id="_f3a27d35-5c34-4648-b49e-fec85d7a414c"> <state value="" variable="S325"/> <bbox w="30.0" h="10.0" x="4460.1543" y="5014.0"/> </glyph> <glyph class="state variable" id="_626fe1b0-ae11-491c-b0d8-8b764d80dfa1"> <state value="Ub" variable="S322"/> <bbox w="40.0" h="10.0" x="4494.632" y="5014.0"/> </glyph> <glyph class="state variable" id="_5ad8cd22-f901-49c8-b315-f814f04c2eef"> <state value="P" variable="S256"/> <bbox w="35.0" h="10.0" x="4457.7817" y="4974.0"/> </glyph> <glyph class="state variable" id="_1e75e6a8-c1de-4109-b6ff-551772b37843"> <state value="P" variable="T24"/> <bbox w="30.0" h="10.0" x="4420.7427" y="4974.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s307_akt1_akt2_sa228" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re121:(MAP:survival) PMID:11980723 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end</body> </html> </notes> <label text="FOXO1"/> <bbox w="80.0" h="40.0" x="4831.25" y="4142.0"/> <glyph class="state variable" id="_efd79dfd-8f58-4ef0-98c9-e7a04c650123"> <state value="" variable="S329"/> <bbox w="30.0" h="10.0" x="4816.25" y="4176.722"/> </glyph> <glyph class="state variable" id="_af61451c-a8ff-4fa8-a222-3594552a63a6"> <state value="P" variable="S319"/> <bbox w="35.0" h="10.0" x="4893.75" y="4137.0"/> </glyph> <glyph class="state variable" id="_c66bc8ee-6e5a-4c94-afe5-c0eba9601cc1"> <state value="P" variable="S325"/> <bbox w="35.0" h="10.0" x="4853.6543" y="4177.0"/> </glyph> <glyph class="state variable" id="_980f6886-936e-4534-b99b-846bbb80d23f"> <state value="P" variable="S322"/> <bbox w="35.0" h="10.0" x="4893.132" y="4177.0"/> </glyph> <glyph class="state variable" id="_eddc534f-43a8-45e2-bc78-d04d10c0a75b"> <state value="P" variable="S256"/> <bbox w="35.0" h="10.0" x="4853.7817" y="4137.0"/> </glyph> <glyph class="state variable" id="_6542fe9e-779c-4952-acae-4ad9c0411a10"> <state value="P" variable="T24"/> <bbox w="30.0" h="10.0" x="4816.7427" y="4137.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s308_akt1_akt2_sa234" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re121:(MAP:survival) PMID:11980723 s_wnc2_re58:(MAP:survival) PMID:16511445, PMID:15121840 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end</body> </html> </notes> <label text="CK1*"/> <bbox w="80.0" h="40.0" x="4963.0" y="4077.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s309_akt1_akt2_sa235" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re122:(MAP:survival) PMID:11980723 s_akt2_re123:(MAP:survival) PMID:11980723 PMID:14664696 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end</body> </html> </notes> <label text="FOXO1"/> <bbox w="80.0" h="40.0" x="4831.25" y="4247.0"/> <glyph class="state variable" id="_5e3ac2e2-a643-436c-9dca-bb56b1ae884a"> <state value="P" variable="S329"/> <bbox w="35.0" h="10.0" x="4813.75" y="4281.722"/> </glyph> <glyph class="state variable" id="_51b4eddb-568c-4a1e-9ef5-ea16e8e41808"> <state value="P" variable="S319"/> <bbox w="35.0" h="10.0" x="4893.75" y="4242.0"/> </glyph> <glyph class="state variable" id="_2cadeee4-fedd-42fd-97a5-294c0e39b300"> <state value="P" variable="S325"/> <bbox w="35.0" h="10.0" x="4853.6543" y="4282.0"/> </glyph> <glyph class="state variable" id="_9ef79487-af1d-40c4-871d-a42a64416d77"> <state value="P" variable="S322"/> <bbox w="35.0" h="10.0" x="4893.132" y="4282.0"/> </glyph> <glyph class="state variable" id="_bf14ce23-ef15-4302-b0b0-1b384fd494f2"> <state value="P" variable="S256"/> <bbox w="35.0" h="10.0" x="4853.7817" y="4242.0"/> </glyph> <glyph class="state variable" id="_4612825c-3007-470a-84eb-5f3b1c6b67a7"> <state value="P" variable="T24"/> <bbox w="30.0" h="10.0" x="4816.7427" y="4242.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s310_akt1_akt2_sa236" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re122:(MAP:survival) PMID:11980723 s_wnc2_re56(MAP:survival): DYRK1A/B primes NFAT in the nucleus, DYRK2 in the cytosol PMID:16511445 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A HUGO:DYRK1A HGNC:3091 ENTREZ:1859 UNIPROT:Q13627 GENECARDS:DYRK1A REACTOME:54046 KEGG:1859 ATLASONC:DYRK1AID43234ch21q22 WIKI:DYRK1A DYRK, DYRK1, MNBH Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:11980723 PMID:19685005 Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase References_end Identifiers_begin: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A HUGO:DYRK1A HGNC:3091 ENTREZ:1859 UNIPROT:Q13627 GENECARDS:DYRK1A REACTOME:54046 KEGG:1859 ATLASONC:DYRK1AID43234ch21q22 WIKI:DYRK1A DYRK, DYRK1, MNBH Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:11980723 PMID:19685005 Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase References_end Identifiers_begin: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A HUGO:DYRK1A HGNC:3091 ENTREZ:1859 UNIPROT:Q13627 GENECARDS:DYRK1A REACTOME:54046 KEGG:1859 ATLASONC:DYRK1AID43234ch21q22 WIKI:DYRK1A DYRK, DYRK1, MNBH Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:11980723 PMID:19685005 Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase References_end</body> </html> </notes> <label text="DYRK1A"/> <bbox w="80.0" h="40.0" x="4962.0" y="4194.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s339_akt1_akt2_sa243" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re127:(MAP:survival) PMID:15084260 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 GENECARDS:FOXO3 REACTOME:199273 KEGG:2309 ATLASONC:AF6q21ID125 WIKI:FOXO3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16288288 PMID:17646672 References_end</body> </html> </notes> <label text="FOXO3"/> <bbox w="80.0" h="40.0" x="5176.625" y="2727.6736"/> <glyph class="state variable" id="_73ab6da2-a46f-4c8c-91c4-0e58842e8475"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="5206.625" y="2722.6736"/> </glyph> <glyph class="state variable" id="_3e30db85-5bd0-488e-aa8d-ed9d875d503b"> <state value="P" variable="S644"/> <bbox w="35.0" h="10.0" x="5159.125" y="2762.396"/> </glyph> <glyph class="state variable" id="_c80133ee-8d10-4c40-94e5-8197980d1a4a"> <state value="" variable="T32"/> <bbox w="25.0" h="10.0" x="5164.125" y="2723.6038"/> </glyph> <glyph class="state variable" id="_86814b2b-b64d-4704-9e99-3560a8e8d0cd"> <state value="" variable="S253"/> <bbox w="30.0" h="10.0" x="5241.625" y="2761.8042"/> </glyph> <glyph class="state variable" id="_e693aa6e-49bb-4dbc-b472-bf5fca1818c3"> <state value="" variable="S315"/> <bbox w="30.0" h="10.0" x="5238.207" y="2722.6736"/> </glyph> <glyph class="state variable" id="_92126b42-8580-4a6d-8061-76352818508a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5171.625" y="2742.6736"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s368_akt1_akt2_sa265" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re137:(MAP:survival) PMID:11124803 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 References_end</body> </html> </notes> <label text="CyclinD*"/> <bbox w="80.0" h="40.0" x="6484.0" y="2939.0"/> <glyph class="state variable" id="_de39aaa7-8ea1-4a71-aa40-081b1260b5c9"> <state value="P" variable="T286"/> <bbox w="35.0" h="10.0" x="6546.5" y="2934.2148"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s369_akt1_akt2_sa266" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re137:(MAP:survival) PMID:11124803 s_akt2_re140:(MAP:survival) PMID:18006823 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27 Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="p27KIP1*"/> <bbox w="80.0" h="40.0" x="5947.0" y="3293.0"/> <glyph class="state variable" id="_80b7975a-5359-4555-9559-386cf479e483"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5982.0" y="3288.0"/> </glyph> <glyph class="state variable" id="_c8c75c76-4797-496a-91ca-32b8a8a559fd"> <state value="P" variable="S157"/> <bbox w="35.0" h="10.0" x="6009.5" y="3288.0"/> </glyph> <glyph class="state variable" id="_d6faac27-e797-4925-bfe9-a112abf11ee6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5982.0" y="3328.0"/> </glyph> <glyph class="state variable" id="_dbc41efe-6d2f-49f0-b2fc-feaeeafd516f"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5962.9316" y="3288.0"/> </glyph> <glyph class="state variable" id="_f751dca7-4826-4de5-b268-eef4be0ec194"> <state value="" variable="S10"/> <bbox w="25.0" h="10.0" x="5934.5" y="3290.402"/> </glyph> <glyph class="state variable" id="_e8fba651-30c0-43fb-a191-92a6619cc5ae"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="6011.382" y="3328.0"/> </glyph> <glyph class="state variable" id="_5442d779-287a-4ec1-8201-f9ba7464ed77"> <state value="" variable="T157"/> <bbox w="30.0" h="10.0" x="6008.582" y="3288.0"/> </glyph> <glyph class="state variable" id="_d41630bc-737c-451b-a89e-25089655908e"> <state value="" variable="T198"/> <bbox w="30.0" h="10.0" x="5932.0" y="3327.7224"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s370_akt1_akt2_sa267" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re137:(MAP:survival) PMID:11124803 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase 4 HUGO:CDK4 HGNC:1773 ENTREZ:1019 UNIPROT:P11802 GENECARDS:CDK4 REACTOME:68329 KEGG:1019 ATLASONC:CDK4ID238ch12q14 WIKI:CDK4 cyclin-dependent kinase 6 HUGO:CDK6 HGNC:1777 ENTREZ:1021 UNIPROT:Q00534 GENECARDS:CDK6 REACTOME:68335 KEGG:1021 ATLASONC:GC_CDK6 WIKI:CDK6 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 References_end</body> </html> </notes> <label text="CDK4_6*"/> <bbox w="80.0" h="40.0" x="5930.5" y="2947.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s377_akt1_akt2_sa272" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re140:(MAP:survival) PMID:18006823 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27 Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="p27KIP1*"/> <bbox w="80.0" h="40.0" x="6227.0" y="3292.0"/> <glyph class="state variable" id="_d8d94a0d-bac1-4510-a638-8ab92e64b0e1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6262.0" y="3287.0"/> </glyph> <glyph class="state variable" id="_5cd10641-25db-423c-a707-cc04306a0bcf"> <state value="P" variable="S157"/> <bbox w="35.0" h="10.0" x="6289.5" y="3287.0"/> </glyph> <glyph class="state variable" id="_a234f976-faae-4293-8cda-3bd637cd72bf"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="6257.0" y="3327.0"/> </glyph> <glyph class="state variable" id="_619feb90-10ed-43a2-b159-e040eface931"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="6242.9316" y="3287.0"/> </glyph> <glyph class="state variable" id="_9565e943-2983-4670-b7d5-6b40c0f0008e"> <state value="" variable="S10"/> <bbox w="25.0" h="10.0" x="6214.5" y="3289.402"/> </glyph> <glyph class="state variable" id="_92f2d33f-099b-4441-ae8a-8d3aeb5677a2"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="6291.382" y="3327.0"/> </glyph> <glyph class="state variable" id="_657c6f96-ba8e-446f-a850-27c8352aa22f"> <state value="" variable="T157"/> <bbox w="30.0" h="10.0" x="6288.582" y="3287.0"/> </glyph> <glyph class="state variable" id="_81e3123f-47c2-4a45-ad98-46902dca6f48"> <state value="" variable="T198"/> <bbox w="30.0" h="10.0" x="6212.0" y="3326.7224"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s381_akt1_akt2_sa275" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re143:(MAP:survival) PMID:11756412 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: proliferating cell nuclear antigen HUGO:PCNA HGNC:8729 ENTREZ:5111 UNIPROT:P12004 GENECARDS:PCNA REACTOME:97870 ATLASONC:PCNAID41670ch20p12 WIKI:PCNA Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:BER MAP:dnarepair / MODULE:MMR MAP:dnarepair / MODULE:TLS MAP:cellcycle / MODULE:P21CIP MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11756412 References_end</body> </html> </notes> <label text="PCNA"/> <bbox w="80.0" h="40.0" x="6150.0" y="3838.0"/> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s383_akt1_akt2_sa277" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 GENECARDS:CDKN1A REACTOME:87048 KEGG:1026 ATLASONC:CDKN1AID139 WIKI:CDKN1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:P21CIP MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19440234 PMID:12851486 References_end</body> </html> </notes> <label text="p21CIP1*"/> <bbox w="80.0" h="40.0" x="6265.0" y="3838.0"/> <glyph class="state variable" id="_0dbb7ace-417a-461c-b2a6-b4b7f23a72f6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6260.0" y="3873.0"/> </glyph> <glyph class="state variable" id="_60282edc-da39-443d-b713-4036d52a447d"> <state value="" variable="T145"/> <bbox w="30.0" h="10.0" x="6250.4927" y="3833.0"/> </glyph> <glyph class="state variable" id="_8bd88c4b-f665-413c-a385-2ef52b778b61"> <state value="" variable="T146"/> <bbox w="30.0" h="10.0" x="6290.0317" y="3833.0"/> </glyph> <glyph class="state variable" id="_69f61cb3-6054-4ecb-82f3-8976593a621f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6340.0" y="3853.4016"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s387_akt1_akt2_sa280" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re144:(MAP:survival) PMID:11463845 PMID:11756412 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 GENECARDS:CDKN1A REACTOME:87048 KEGG:1026 ATLASONC:CDKN1AID139 WIKI:CDKN1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:P21CIP MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19440234 PMID:12851486 References_end</body> </html> </notes> <label text="p21CIP1*"/> <bbox w="80.0" h="40.0" x="6264.5" y="3730.0"/> <glyph class="state variable" id="_8848d1fd-2516-48e8-b7aa-ed8219d378c9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6259.5" y="3765.0"/> </glyph> <glyph class="state variable" id="_ba890143-a845-4bd7-a22f-2ce8443be773"> <state value="" variable="T145"/> <bbox w="30.0" h="10.0" x="6249.9927" y="3725.0"/> </glyph> <glyph class="state variable" id="_9646987c-d034-4955-aab4-89634b45b3e1"> <state value="" variable="T146"/> <bbox w="30.0" h="10.0" x="6289.5317" y="3725.0"/> </glyph> <glyph class="state variable" id="_3bf2814e-9843-4f9d-912d-fb67c5e0af40"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6339.5" y="3745.4016"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s389_akt1_akt2_sa282" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re146:(MAP:survival) PMID:11756412 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 GENECARDS:CDKN1A REACTOME:87048 KEGG:1026 ATLASONC:CDKN1AID139 WIKI:CDKN1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:P21CIP MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19440234 PMID:12851486 References_end</body> </html> </notes> <label text="p21CIP1*"/> <bbox w="80.0" h="40.0" x="6265.5" y="3634.0"/> <glyph class="state variable" id="_f0b961c2-2511-455b-88b5-07e4f073b810"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6260.5" y="3669.0"/> </glyph> <glyph class="state variable" id="_af053316-cfb0-4e40-b7de-0b420e5c8ee3"> <state value="" variable="T145"/> <bbox w="30.0" h="10.0" x="6250.9927" y="3629.0"/> </glyph> <glyph class="state variable" id="_119d8475-f060-493e-b4fe-e3c0d5f583f2"> <state value="" variable="T146"/> <bbox w="30.0" h="10.0" x="6290.5317" y="3629.0"/> </glyph> <glyph class="state variable" id="_ec841df8-14e3-4d46-abda-7ab9c8bdf3b6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6340.5" y="3649.4016"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s388_akt1_akt2_sa281" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 GENECARDS:CDKN1A REACTOME:87048 KEGG:1026 ATLASONC:CDKN1AID139 WIKI:CDKN1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:P21CIP MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19440234 PMID:12851486 References_end</body> </html> </notes> <label text="p21CIP1*"/> <bbox w="80.0" h="40.0" x="6747.5" y="3691.0"/> <glyph class="state variable" id="_abc74e22-878a-46a1-8dec-76bd1a6c7218"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6742.5" y="3726.0"/> </glyph> <glyph class="state variable" id="_7632f88a-ad66-4565-8b6c-98f4deb4a636"> <state value="" variable="T145"/> <bbox w="30.0" h="10.0" x="6732.9927" y="3686.0"/> </glyph> <glyph class="state variable" id="_61afe9a1-9d14-4655-8693-1035618baf60"> <state value="" variable="T146"/> <bbox w="30.0" h="10.0" x="6772.5317" y="3686.0"/> </glyph> <glyph class="state variable" id="_e93eb83f-620e-432b-8973-9c9e09c64926"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6822.5" y="3706.4016"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s404_akt1_akt2_sa294" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re152:(MAP:survival) PMID:9829964 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cAMP responsive element binding protein 1 HUGO:CREB1 HGNC:2345 ENTREZ:1385 UNIPROT:P16220 GENECARDS:CREB1 REACTOME:52778 KEGG:1385 ATLASONC:GC_CREB1 WIKI:CREB1 cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17565603 References_end</body> </html> </notes> <label text="CREB*"/> <bbox w="80.0" h="40.0" x="6006.0" y="4484.0"/> <glyph class="state variable" id="_da3989f2-8831-411b-90e7-761fdadc622f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6001.0" y="4479.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s407_akt1_akt2_sa297" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re152:(MAP:survival) PMID:9829964 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cAMP responsive element binding protein 1 HUGO:CREB1 HGNC:2345 ENTREZ:1385 UNIPROT:P16220 GENECARDS:CREB1 REACTOME:52778 KEGG:1385 ATLASONC:GC_CREB1 WIKI:CREB1 cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17565603 References_end</body> </html> </notes> <label text="CREB*"/> <bbox w="80.0" h="40.0" x="6138.25" y="4486.0"/> <glyph class="state variable" id="_ac52c047-e18d-47ca-9a64-0db330230b83"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="6130.75" y="4481.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s409_akt1_akt2_sa298" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re153:(MAP:survival) PMID:9829964 s_wca3_re8(MAP:survival): MEK/ERK cascade activation is the upstream signal required for phosphorylation. PMID:21751375 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end</body> </html> </notes> <label text="CBP*"/> <bbox w="80.0" h="40.0" x="6135.0" y="4424.0"/> <glyph class="state variable" id="_2f2acf3f-ab0a-4121-9835-0686570c518b"> <state value="" variable="S92"/> <bbox w="25.0" h="10.0" x="6122.9927" y="4419.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s427_akt1_akt2_sa308" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re158:(MAP:survival) PMID:21505104 s_akt2_re159:(MAP:survival) PMID:17646672 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end</body> </html> </notes> <label text="FOXO1"/> <bbox w="80.0" h="40.0" x="6240.25" y="4176.0"/> <glyph class="state variable" id="_aa598b07-5a23-45fb-90ba-2fede1c32ab8"> <state value="" variable="S329"/> <bbox w="30.0" h="10.0" x="6225.25" y="4210.722"/> </glyph> <glyph class="state variable" id="_bd50965c-f8cc-48a7-b0c0-6d1cbe570daf"> <state value="" variable="S319"/> <bbox w="30.0" h="10.0" x="6305.25" y="4171.0"/> </glyph> <glyph class="state variable" id="_9f53bd84-1991-48d9-ae41-a73421468bd6"> <state value="" variable="S325"/> <bbox w="30.0" h="10.0" x="6265.1543" y="4211.0"/> </glyph> <glyph class="state variable" id="_72e77459-8654-4957-8570-8c4cd3bfca43"> <state value="" variable="S322"/> <bbox w="30.0" h="10.0" x="6304.632" y="4211.0"/> </glyph> <glyph class="state variable" id="_ee78f613-4649-46ec-8496-5e4e727bd1b7"> <state value="" variable="S256"/> <bbox w="30.0" h="10.0" x="6265.2817" y="4171.0"/> </glyph> <glyph class="state variable" id="_fb62a6ff-59ed-43c4-82ad-2ce658e6cd7e"> <state value="" variable="T24"/> <bbox w="25.0" h="10.0" x="6228.2427" y="4171.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_s_akt2_s428_akt1_akt2_sa309" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re157:(MAP:survival) PMID:20580290 s_akt2_re158:(MAP:survival) PMID:21505104 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Runt-related transcription factor 2 HUGO:RUNX2 HGNC:10472 ENTREZ:860 UNIPROT:Q13950 GENECARDS:RUNX2 REACTOME:63858 KEGG:860 ATLASONC:RUNX2ID42183ch6p21 WIKI:RUNX2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20946121 PMID:20580290 References_end</body> </html> </notes> <label text="RUNX2"/> <bbox w="80.0" h="40.0" x="6381.0" y="4176.0"/> </glyph> <glyph class="phenotype" id="akt1_s_akt2_s382_akt1_akt2_sa276" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <label text="DNA synthesis"/> <bbox w="80.0" h="30.0" x="5823.0" y="3827.0"/> </glyph> <glyph class="phenotype" id="akt1_s_akt2_s86_akt1_akt2_sa80" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <label text="G1 phase"/> <bbox w="80.0" h="30.0" x="5397.0" y="2952.0"/> </glyph> <glyph class="phenotype" id="akt1_s_akt2_s81_akt1_akt2_sa75" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <label text="G0 phase"/> <bbox w="80.0" h="30.0" x="5675.0" y="2952.0"/> </glyph> <glyph class="phenotype" id="akt1_s_akt2_s119_akt1_akt2_sa106" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <label text="S phase"/> <bbox w="80.0" h="30.0" x="5779.0" y="2952.0"/> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s6_akt1_akt2_sa6" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27 Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="p27KIP1*"/> <bbox w="70.0" h="25.0" x="5129.5" y="3024.5"/> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s11_akt1_akt2_sa12" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re4:(MAP:survival) PMID:20673124 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 GENECARDS:BCL2L11 REACTOME:401534 KEGG:10018 ATLASONC:BCL2L11ID772ch2q13 WIKI:BCL2L11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19934277 PMID:20673124 References_end</body> </html> </notes> <label text="BCL2L11"/> <bbox w="70.0" h="25.0" x="5129.5" y="3097.5"/> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s31_akt1_akt2_sa25" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re10:(MAP:survival) PMID:20673124 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2 binding component 3 HUGO:BBC3 HGNC:17868 ENTREZ:27113 UNIPROT:Q96PG8 GENECARDS:BBC3 KEGG:27113 ATLASONC:BBC3ID759ch19q13 WIKI:BBC3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19652530 PMID:20673124 References_end</body> </html> </notes> <label text="BBC3"/> <bbox w="70.0" h="25.0" x="5129.5" y="3169.5"/> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s33_akt1_akt2_sa27" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re11:(MAP:survival) PMID:20673124 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Fas ligand (TNF superfamily member 6) HUGO:FASLG HGNC:11936 ENTREZ:356 UNIPROT:P48023 GENECARDS:FASLG REACTOME:66213 KEGG:356 ATLASONC:GC_FASLG WIKI:FASLG Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15160330 PMID:20673124 References_end</body> </html> </notes> <label text="FASL*"/> <bbox w="70.0" h="25.0" x="5129.5" y="3240.5"/> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s35_akt1_akt2_sa29" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re12:(MAP:survival) PMID:20673124 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tumor necrosis factor (ligand) superfamily member 10 HUGO:TNFSF10 HGNC:11925 ENTREZ:8743 UNIPROT:P50591 GENECARDS:TNFSF10 REACTOME:66187 KEGG:8743 ATLASONC:TNFSF10ID42632ch3q26 WIKI:TNFSF10 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20935674 PMID:20673124 References_end</body> </html> </notes> <label text="TRAIL*"/> <bbox w="70.0" h="25.0" x="5129.5" y="3310.5"/> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s47_akt1_akt2_sa42" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re20:(MAP:survival) PMID:17218262 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: RAD51 homo HUGO:RAD51 HGNC:9817 ENTREZ:5888 UNIPROT:Q06609 GENECARDS:RAD51 REACTOME:62638 KEGG:5888 ATLASONC:GC_RAD51 WIKI:RAD51 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18716620 PMID:20673124 References_end</body> </html> </notes> <label text="RAD51"/> <bbox w="70.0" h="25.0" x="5129.5" y="3408.5"/> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s166_akt1_akt2_sa138" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re61(MAP:survival): PMID15509806 PMID20673124 s_wca3_re116(MAP:survival): PMID:22761862 Swi/SNF complex PMID:22290435 NuRD complex: b-catenin/CTBP/Hipk2/LEF1 complex PMID:17666529 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 "B-cell CLL/lymphoma 1" "G1/S-specific cyclin D1" "parathyroid adenomatosis 1" U21B31 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18414028 PMID:20673124 PMID:19887899 References_end Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 "B-cell CLL/lymphoma 1" "G1/S-specific cyclin D1" "parathyroid adenomatosis 1" U21B31 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18414028 PMID:20673124 PMID:19887899 References_end Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 "B-cell CLL/lymphoma 1" "G1/S-specific cyclin D1" "parathyroid adenomatosis 1" U21B31 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18414028 PMID:20673124 PMID:19887899 References_end</body> </html> </notes> <label text="CyclinD*"/> <bbox w="70.0" h="25.0" x="5129.5" y="3556.5"/> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s186_akt1_akt2_sa145" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 GENECARDS:MDM2 REACTOME:95018 KEGG:4193 ATLASONC:MDM2ID115ch12q15 WIKI:MDM2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20679392 PMID:15169778 PMID:11923280 PMID:11715018 PMID:20673124 References_end</body> </html> </notes> <label text="MDM2"/> <bbox w="70.0" h="25.0" x="5127.5" y="3714.5"/> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s205_akt1_akt2_sa162" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: growth arrest and DNA-damage-inducible alpha DDIT1 HUGO:GADD45A HGNC:4095 ENTREZ:1647 UNIPROT:P24522 growth arrest and DNA-damage-inducible beta MYD118 HUGO:GADD45B HGNC:4096 ENTREZ:4616 UNIPROT:O75293 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: growth arrest and DNA-damage-inducible alpha DDIT1 HUGO:GADD45A HGNC:4095 ENTREZ:1647 UNIPROT:P24522 GENECARDS:GADD45A KEGG:1647 ATLASONC:GC_GADD45A WIKI:GADD45A growth arrest and DNA-damage-inducible beta MYD118 HUGO:GADD45B HGNC:4096 ENTREZ:4616 UNIPROT:O75293 GENECARDS:GADD45B KEGG:4616 ATLASONC:GC_GADD45B WIKI:GADD45B growth arrest and DNA-damage-inducible gamma HUGO:GADD45G HGNC:4097 ENTREZ:10912 UNIPROT:O95257 GENECARDS:GADD45G KEGG:10912 ATLASONC:GC_GADD45G WIKI:GADD45G Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20025601 PMID:20673124 References_end</body> </html> </notes> <label text="GADD45*"/> <bbox w="70.0" h="25.0" x="5129.5" y="3359.5"/> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s214_akt1_akt2_sa170" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re86:(MAP:survival) PMID:15509806 PMID:20673124 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: B-cell CLL/lymphoma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15509806 PMID:20673124 References_end</body> </html> </notes> <label text="BCL6"/> <bbox w="70.0" h="25.0" x="5127.5" y="3764.5"/> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s237_akt1_akt2_sa184" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re93:(MAP:survival) PMID19244250 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15668399 PMID:20673124 References_end</body> </html> </notes> <label text="FOXO1"/> <bbox w="70.0" h="25.0" x="5128.5" y="3813.5"/> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s239_akt1_akt2_sa186" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 GENECARDS:CDKN1A REACTOME:87048 KEGG:1026 ATLASONC:CDKN1AID139 WIKI:CDKN1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19440234 PMID:20673124 References_end</body> </html> </notes> <label text="p21CIP1*"/> <bbox w="70.0" h="25.0" x="5128.5" y="3894.5"/> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s241_akt1_akt2_sa188" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re96:(MAP:survival) PMID:20673124 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 2B (p15 inhibits CDK4) HUGO:CDKN2B HGNC:1788 ENTREZ:1030 UNIPROT:P42772 GENECARDS:CDKN2B REACTOME:87041 KEGG:1030 ATLASONC:CDKN2BID187ch9p21 WIKI:CDKN2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12542976 PMID:20673124 References_end</body> </html> </notes> <label text="p15INK4B*"/> <bbox w="70.0" h="25.0" x="5128.5" y="3931.5"/> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s243_akt1_akt2_sa190" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re97:(MAP:survival) PMID:20673124 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase inhibitor 2D (p19 inhibits CDK4) HUGO:CDKN2D HGNC:1790 ENTREZ:1032 UNIPROT:P55273 GENECARDS:CDKN2D REACTOME:87046 KEGG:1032 ATLASONC:GC_CDKN2D WIKI:CDKN2D Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12542976 PMID:20673124 References_end</body> </html> </notes> <label text="p19INK4D*"/> <bbox w="70.0" h="25.0" x="5128.5" y="3980.5"/> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s245_akt1_akt2_sa192" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HGNC:9077 ENTREZ:5347 UNIPROT:P53350 HGNC:19699 ENTREZ:10769 UNIPROT:Q9NYY3 HGNC:2154 ENTREZ:1263 UNIPROT:Q9H4B4 HGNC:11397 ENTREZ:10733 UNIPROT:O00444 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20068088 PMID:20673124 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: polo-like kinase 1 HUGO:PLK1 HGNC:9077 ENTREZ:5347 UNIPROT:P53350 GENECARDS:PLK1 REACTOME:69858 KEGG:5347 ATLASONC:PLK1ID41747ch16p12 WIKI:PLK1 polo-like kinase 2 HUGO:PLK2 HGNC:19699 ENTREZ:10769 UNIPROT:Q9NYY3 GENECARDS:PLK2 KEGG:10769 ATLASONC:GC_PLK2 WIKI:PLK2 polo-like kinase 3 HUGO:PLK3 HGNC:2154 ENTREZ:1263 UNIPROT:Q9H4B4 GENECARDS:PLK3 KEGG:1263 ATLASONC:GC_PLK3 WIKI:PLK3 polo-like kinase 4 HUGO:PLK4 HGNC:11397 ENTREZ:10733 UNIPROT:O00444 GENECARDS:PLK4 REACTOME:152249 KEGG:10733 ATLASONC:GC_PLK4 WIKI:PLK4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20068088 PMID:20673124 References_end</body> </html> </notes> <label text="PLK1"/> <bbox w="70.0" h="25.0" x="5127.5" y="3672.5"/> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s247_akt1_akt2_sa194" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re99:(MAP:survival) PMID:20673124 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: TNFRSF1A-associated via death domain HUGO:TRADD HGNC:12030 ENTREZ:8717 UNIPROT:Q15628 GENECARDS:TRADD REACTOME:66377 KEGG:8717 ATLASONC:GC_TRADD WIKI:TRADD Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19893571 PMID:20673124 References_end</body> </html> </notes> <label text="TRADD"/> <bbox w="70.0" h="25.0" x="5128.5" y="4023.5"/> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s251_akt1_akt2_sa198" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re101:(MAP:survival) PMID:20673124 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: PTEN induced putative kinase 1 HUGO:PINK1 HGNC:14581 ENTREZ:65018 UNIPROT:Q9BXM7 GENECARDS:PINK1 KEGG:65018 ATLASONC:GC_PINK1 WIKI:PINK1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21179058 PMID:20673124 References_end</body> </html> </notes> <label text="PINK1"/> <bbox w="70.0" h="25.0" x="5128.5" y="4069.5"/> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s253_akt1_akt2_sa200" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re102:(MAP:survival) PMID:20673124 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O3 HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 GENECARDS:FOXO3 REACTOME:199273 KEGG:2309 ATLASONC:AF6q21ID125 WIKI:FOXO3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20673124 PMID:16288288 PMID:17646672 References_end</body> </html> </notes> <label text="FOXO3"/> <bbox w="70.0" h="25.0" x="5128.5" y="3854.5"/> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s255_akt1_akt2_sa202" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re103(MAP:survival): PMID:20673124 PMID:18644865 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphoinositide-3-kinase catalytic alpha polypeptide HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 GENECARDS:PIK3CA REACTOME:61074 KEGG:5290 ATLASONC:PIK3CAID415ch3q26 WIKI:PIK3CA phosphoinositide-3-kinase catalytic beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase catalytic delta polypeptide HUGO:PIK3CD HGNC:8977 ENTREZ:5293 UNIPROT:O00329 GENECARDS:PIK3CD REACTOME:61078 KEGG:5293 ATLASONC:PIK3CDID46261ch1p36 WIKI:PIK3CD phosphoinositide-3-kinase catalytic gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 PMID:20673124 References_end</body> </html> </notes> <label text="p110*"/> <bbox w="70.0" h="25.0" x="5128.5" y="4114.5"/> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s402_akt1_akt2_sa292" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: Bcl-2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 GENECARDS:BCL2 REACTOME:50758 KEGG:596 ATLASONC:BCL2ID49 WIKI:BCL2 B-cell CLL/lymphoma 2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18097445 PMID:9735050 References_end</body> </html> Identifiers_begin: Bcl-2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 GENECARDS:BCL2 REACTOME:50758 KEGG:596 ATLASONC:BCL2ID49 WIKI:BCL2 B-cell CLL/lymphoma 2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18097445 PMID:9735050 References_end</body> </html> </notes> <label text="BCL2"/> <bbox w="70.0" h="25.0" x="6379.0" y="4514.5"/> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s406_akt1_akt2_sa18" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re157:(MAP:survival) PMID:20580290 References_end</body> </html> </notes> <label text="promoter_region"/> <clone/> <bbox w="70.0" h="25.0" x="4695.25" y="3104.5"/> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s406_akt1_akt2_sa296" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re157:(MAP:survival) PMID:20580290 References_end</body> </html> </notes> <label text="promoter_region"/> <clone/> <bbox w="70.0" h="25.0" x="6140.0" y="4552.5"/> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s406_akt1_akt2_sa310" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re157:(MAP:survival) PMID:20580290 References_end</body> </html> </notes> <label text="promoter_region"/> <clone/> <bbox w="70.0" h="25.0" x="6513.5" y="4183.0"/> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s412_akt1_akt2_sa302" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re154:(MAP:survival) PMID:10454566 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: myeloid cell leukemia sequence 1 (BCL2-related) HUGO:MCL1 HGNC:6943 ENTREZ:4170 UNIPROT:Q07820 GENECARDS:MCL1 KEGG:4170 ATLASONC:GC_MCL1 WIKI:MCL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20540941 PMID:10454566 References_end</body> </html> </notes> <label text="MCL1"/> <bbox w="70.0" h="25.0" x="6379.0" y="4465.5"/> </glyph> <glyph class="complex" id="akt1_s_akt2_s25_akt1_akt2_csa4" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:FOXO3 Identifiers_end References_begin: s_akt2_re8:(MAP:survival) PMID:11864996 References_end</body> </html> </notes> <label text="14-3-3*:FOXO3"/> <bbox w="100.0" h="120.0" x="4751.0" y="3262.0"/> <glyph class="macromolecule" id="akt1_akt2_s26_akt1_akt2_sa21"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="4758.5" y="3268.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s27_akt1_akt2_sa22"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 GENECARDS:FOXO3 REACTOME:199273 KEGG:2309 ATLASONC:AF6q21ID125 WIKI:FOXO3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16288288 PMID:17646672 References_end</body> </html> </notes> <label text="FOXO3"/> <bbox w="80.0" h="40.0" x="4757.75" y="3315.5"/> <glyph class="state variable" id="_93d20c1d-df1b-475c-9014-a357d912a834"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4792.75" y="3310.5"/> </glyph> <glyph class="state variable" id="_c4d9bda1-f529-432a-8c12-386f8e06988b"> <state value="" variable="S644"/> <bbox w="30.0" h="10.0" x="4742.75" y="3350.2224"/> </glyph> <glyph class="state variable" id="_6e9ce05f-f1d6-4ff9-a61c-9b110d95cab8"> <state value="" variable="T32"/> <bbox w="25.0" h="10.0" x="4745.25" y="3311.4302"/> </glyph> <glyph class="state variable" id="_fcf9db6f-96b8-43b9-ad6f-492fe1194e21"> <state value="" variable="S253"/> <bbox w="30.0" h="10.0" x="4822.75" y="3349.6306"/> </glyph> <glyph class="state variable" id="_98e9b66f-f9eb-482a-a488-26cbd5c0fe3f"> <state value="" variable="S315"/> <bbox w="30.0" h="10.0" x="4819.332" y="3310.5"/> </glyph> <glyph class="state variable" id="_609c1010-e05e-4aaa-9f74-928f5ccea7fe"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4752.75" y="3330.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s28_akt1_akt2_csa5" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:FOXO3 Identifiers_end References_begin: s_akt2_re9:(MAP:survival) PMID:11864996 References_end</body> </html> </notes> <label text="14-3-3*:FOXO3"/> <bbox w="100.0" h="120.0" x="4420.5" y="3133.0"/> <glyph class="macromolecule" id="akt1_akt2_s29_akt1_akt2_sa23"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="4428.0" y="3139.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s30_akt1_akt2_sa24"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 GENECARDS:FOXO3 REACTOME:199273 KEGG:2309 ATLASONC:AF6q21ID125 WIKI:FOXO3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16288288 PMID:17646672 References_end</body> </html> </notes> <label text="FOXO3"/> <bbox w="80.0" h="40.0" x="4427.25" y="3186.5"/> <glyph class="state variable" id="_5d060a5f-e8a7-4ad7-8092-0837e656b9eb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4462.25" y="3181.5"/> </glyph> <glyph class="state variable" id="_dcff2335-2ee7-4a96-a797-a9bccf775c51"> <state value="" variable="S644"/> <bbox w="30.0" h="10.0" x="4412.25" y="3221.2224"/> </glyph> <glyph class="state variable" id="_0a699be0-a489-44b4-ae8e-601c144f2462"> <state value="" variable="T32"/> <bbox w="25.0" h="10.0" x="4414.75" y="3182.4302"/> </glyph> <glyph class="state variable" id="_89096be5-9710-44a3-ab75-4a5ad8edbf65"> <state value="" variable="S253"/> <bbox w="30.0" h="10.0" x="4492.25" y="3220.6306"/> </glyph> <glyph class="state variable" id="_e6f1312b-5118-4915-906a-37c54ad8d689"> <state value="" variable="S315"/> <bbox w="30.0" h="10.0" x="4488.832" y="3181.5"/> </glyph> <glyph class="state variable" id="_4ef3931c-9b2d-4593-96af-45d86c10cc1b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4422.25" y="3201.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s95_akt1_akt2_csa12" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK2:CyclinE* Identifiers_end References_begin: s_akt2_re38(MAP:survival): PMID:18636226 PMID:15147722 PMID:14536078 PMID:12459251 s_akt2_re39:(MAP:survival) PMID:15147722 PMID:18006823 References_end</body> </html> </notes> <label text="CDK2:CyclinE*"/> <bbox w="100.0" h="120.0" x="5735.0" y="3219.0"/> <glyph class="macromolecule" id="akt1_akt2_s97_akt1_akt2_sa87"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin E1 HUGO:CCNE1 HGNC:1589 ENTREZ:898 UNIPROT:P24864 GENECARDS:CCNE1 REACTOME:87225 KEGG:898 ATLASONC:GC_CCNE1 WIKI:CCNE1 cyclin E2 HUGO:CCNE2 HGNC:1590 ENTREZ:9134 UNIPROT:O96020 GENECARDS:CCNE2 REACTOME:87228 KEGG:9134 ATLASONC:GC_CCNE2 WIKI:CCNE2 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:cellcycle / MODULE:CYCLINE MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:15147722 PMID:14536078 References_end</body> </html> </notes> <label text="CyclinE*"/> <bbox w="80.0" h="40.0" x="5743.5" y="3225.0"/> <glyph class="state variable" id="_393ea1d5-053c-4717-9738-4347398d0c03"> <state value="" variable="S384"/> <bbox w="30.0" h="10.0" x="5808.5" y="3220.2148"/> </glyph> <glyph class="state variable" id="_b7d5980e-2cd4-4571-a403-14a714a74b0e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5738.5" y="3260.0"/> </glyph> <glyph class="state variable" id="_894c0976-c35b-4088-9171-42c4f44fdc18"> <state value="" variable="T380"/> <bbox w="30.0" h="10.0" x="5728.5" y="3220.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s98_akt1_akt2_sa88"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 2 HUGO:CDK2 HGNC:1771 ENTREZ:1017 UNIPROT:P24941 GENECARDS:CDK2 REACTOME:87018 KEGG:1017 ATLASONC:GC_CDK2 WIKI:CDK2 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:dnarepair / MODULE:S_CC_PHASE MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:15147722 PMID:14536078 References_end</body> </html> </notes> <label text="CDK2"/> <bbox w="80.0" h="40.0" x="5745.5" y="3267.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s96_akt1_akt2_csa11" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK2:CyclinE*:p27KIP1* Identifiers_end References_begin: s_akt2_re37(MAP:survival): PMID:18636226 PMID:15147722 PMID:14536078 s_akt2_re38(MAP:survival): PMID:12459251 References_end</body> </html> </notes> <label text="CDK2:CyclinE*:p27KIP1*"/> <bbox w="182.0" h="116.0" x="5397.0" y="3221.0"/> <glyph class="macromolecule" id="akt1_akt2_s90_akt1_akt2_sa83"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin E1 HUGO:CCNE1 HGNC:1589 ENTREZ:898 UNIPROT:P24864 GENECARDS:CCNE1 REACTOME:87225 KEGG:898 ATLASONC:GC_CCNE1 WIKI:CCNE1 cyclin E2 HUGO:CCNE2 HGNC:1590 ENTREZ:9134 UNIPROT:O96020 GENECARDS:CCNE2 REACTOME:87228 KEGG:9134 ATLASONC:GC_CCNE2 WIKI:CCNE2 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:cellcycle / MODULE:CYCLINE MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:15147722 PMID:14536078 References_end</body> </html> </notes> <label text="CyclinE*"/> <bbox w="80.0" h="40.0" x="5406.5" y="3230.0"/> <glyph class="state variable" id="_ee09fd6c-5941-454a-a796-8ad8c29b7170"> <state value="" variable="S384"/> <bbox w="30.0" h="10.0" x="5471.5" y="3225.2148"/> </glyph> <glyph class="state variable" id="_e1d451a3-97c8-4048-aa02-e079225b15e9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5401.5" y="3265.0"/> </glyph> <glyph class="state variable" id="_75c8dc7c-a69c-4d5f-acf3-22ec95e20473"> <state value="" variable="T380"/> <bbox w="30.0" h="10.0" x="5391.5" y="3225.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s91_akt1_akt2_sa84"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 2 HUGO:CDK2 HGNC:1771 ENTREZ:1017 UNIPROT:P24941 GENECARDS:CDK2 REACTOME:87018 KEGG:1017 ATLASONC:GC_CDK2 WIKI:CDK2 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:dnarepair / MODULE:S_CC_PHASE MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:15147722 PMID:14536078 References_end</body> </html> </notes> <label text="CDK2"/> <bbox w="80.0" h="40.0" x="5405.5" y="3272.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s93_akt1_akt2_sa85"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27 Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="p27KIP1*"/> <bbox w="80.0" h="40.0" x="5488.0" y="3231.0"/> <glyph class="state variable" id="_f13e85d9-9e44-4399-a070-8d8487b81738"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5523.0" y="3226.0"/> </glyph> <glyph class="state variable" id="_9af2e64d-8c5d-47d8-91e1-11144fc8a103"> <state value="" variable="S157"/> <bbox w="30.0" h="10.0" x="5553.0" y="3226.0"/> </glyph> <glyph class="state variable" id="_21e894c6-6a9a-4c0b-a0b4-8b2936dec470"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5523.0" y="3266.0"/> </glyph> <glyph class="state variable" id="_28efc50a-5577-4d25-8eba-154defb00c2f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5506.4316" y="3226.0"/> </glyph> <glyph class="state variable" id="_6da9f588-7da5-4afe-a8f3-34ae66d013e0"> <state value="" variable="S10"/> <bbox w="25.0" h="10.0" x="5475.5" y="3228.402"/> </glyph> <glyph class="state variable" id="_e641f920-869d-4db7-b18b-a3befecd3446"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="5552.382" y="3266.0"/> </glyph> <glyph class="state variable" id="_f5861179-c1c0-4794-a080-fe719fb9fb22"> <state value="" variable="T157"/> <bbox w="30.0" h="10.0" x="5549.582" y="3226.0"/> </glyph> <glyph class="state variable" id="_7966df19-f46e-49ba-9cdb-13eb74162810"> <state value="" variable="T198"/> <bbox w="30.0" h="10.0" x="5473.0" y="3265.7224"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s102_akt1_akt2_csa13" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CRM1*:p27KIP1* Identifiers_end References_begin: s_akt2_re43:(MAP:survival) PMID:18636226 References_end</body> </html> </notes> <label text="CRM1*:p27KIP1*"/> <bbox w="100.0" h="120.0" x="6463.0" y="3276.0"/> <glyph class="macromolecule" id="akt1_akt2_s103_akt1_akt2_sa93"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> </notes> <label text="CRM1*"/> <bbox w="80.0" h="40.0" x="6471.5" y="3284.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s104_akt1_akt2_sa94"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27 Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="p27KIP1*"/> <bbox w="80.0" h="40.0" x="6473.0" y="3326.0"/> <glyph class="state variable" id="_fc4c7a72-8299-4eef-8bd5-22a9a15f59a0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6508.0" y="3321.0"/> </glyph> <glyph class="state variable" id="_c3f67753-844d-4309-abf1-eb3c3455cd64"> <state value="" variable="S157"/> <bbox w="30.0" h="10.0" x="6538.0" y="3321.0"/> </glyph> <glyph class="state variable" id="_0d5dd6d9-6d93-4986-a18e-7495b76648aa"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6508.0" y="3361.0"/> </glyph> <glyph class="state variable" id="_4c2356e1-2a30-48b5-b0fc-beb357975b60"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6491.4316" y="3321.0"/> </glyph> <glyph class="state variable" id="_c2e9313e-90eb-4f61-96fd-e81b5c6384e3"> <state value="" variable="S10"/> <bbox w="25.0" h="10.0" x="6460.5" y="3323.402"/> </glyph> <glyph class="state variable" id="_05a79786-222f-4f8c-a871-55a9ee0d92cc"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="6537.382" y="3361.0"/> </glyph> <glyph class="state variable" id="_683b5aec-5e1f-415b-9adc-d72482c56f04"> <state value="" variable="T157"/> <bbox w="30.0" h="10.0" x="6534.582" y="3321.0"/> </glyph> <glyph class="state variable" id="_4bc69f15-fc22-44be-ab16-78f254da6fb6"> <state value="" variable="T198"/> <bbox w="30.0" h="10.0" x="6458.0" y="3360.7224"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s105_akt1_akt2_csa14" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CRM1*:p27KIP1* Identifiers_end References_begin: s_akt2_re44:(MAP:survival) PMID:18636226 References_end</body> </html> </notes> <label text="CRM1*:p27KIP1*"/> <bbox w="100.0" h="120.0" x="6699.5" y="3120.0"/> <glyph class="macromolecule" id="akt1_akt2_s106_akt1_akt2_sa95"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> </notes> <label text="CRM1*"/> <bbox w="80.0" h="40.0" x="6708.0" y="3128.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s107_akt1_akt2_sa96"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27 Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="p27KIP1*"/> <bbox w="80.0" h="40.0" x="6710.5" y="3172.0"/> <glyph class="state variable" id="_4598011a-776a-4478-833b-1e0160d268d4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6745.5" y="3167.0"/> </glyph> <glyph class="state variable" id="_6d474623-0a55-4be7-b420-7f3b863dec73"> <state value="" variable="S157"/> <bbox w="30.0" h="10.0" x="6775.5" y="3167.0"/> </glyph> <glyph class="state variable" id="_424b8418-1c36-4aeb-a1ab-a278be1b7969"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6745.5" y="3207.0"/> </glyph> <glyph class="state variable" id="_fa556795-44f5-458f-a957-7e8b7e0232a7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6728.9316" y="3167.0"/> </glyph> <glyph class="state variable" id="_cf716a11-2ad0-4034-8d28-ffe14fc08380"> <state value="" variable="S10"/> <bbox w="25.0" h="10.0" x="6698.0" y="3169.402"/> </glyph> <glyph class="state variable" id="_5687857d-d68c-4547-a678-d4dd11cf252d"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="6774.882" y="3207.0"/> </glyph> <glyph class="state variable" id="_d110d5bf-4c45-416f-a14e-f5b3562c0d25"> <state value="" variable="T157"/> <bbox w="30.0" h="10.0" x="6772.082" y="3167.0"/> </glyph> <glyph class="state variable" id="_add86c8d-a3e7-406d-a570-301e5955f2ae"> <state value="" variable="T198"/> <bbox w="30.0" h="10.0" x="6695.5" y="3206.7224"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s110_akt1_akt2_csa15" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:KPC1*:KPC2* Identifiers_end References_begin: s_akt2_re46:(MAP:survival) PMID:15531880 References_end</body> </html> </notes> <label text="KPC1*:KPC2*"/> <bbox w="92.0" h="111.0" x="6676.0" y="3460.0"/> <glyph class="macromolecule" id="akt1_akt2_s111_akt1_akt2_sa99"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ring finger protein 123 HUGO:RNF123 HGNC:21148 ENTREZ:63891 UNIPROT:Q5XPI4 GENECARDS:RNF123 REACTOME:246065 KEGG:63891 ATLASONC:GC_RNF123 WIKI:RNF123 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15531880 References_end</body> </html> </notes> <label text="KPC1*"/> <bbox w="80.0" h="40.0" x="6681.0" y="3471.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s112_akt1_akt2_sa100"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: UBA domain containing 1 HUGO:UBAC1 HGNC:30221 ENTREZ:10422 UNIPROT:Q9BSL1 GENECARDS:UBAC1 KEGG:10422 WIKI:UBAC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15531880 References_end</body> </html> </notes> <label text="KPC2*"/> <bbox w="80.0" h="40.0" x="6682.0" y="3512.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s114_akt1_akt2_csa16" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CKS1B:CUL1:SKP1:SKP2 Identifiers_end References_begin: s_akt2_re48:(MAP:survival) PMID:15147722 References_end</body> </html> </notes> <label text="CKS1B:CUL1:SKP1:SKP2"/> <bbox w="172.0" h="112.0" x="5865.0" y="3010.0"/> <glyph class="macromolecule" id="akt1_akt2_s115_akt1_akt2_sa102"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CDC28 protein kinase regulatory subunit 1B HUGO:CKS1B HGNC:19083 ENTREZ:1163 UNIPROT:P61024 GENECARDS:CKS1B REACTOME:69869 KEGG:1163 ATLASONC:CKS1BID40092ch1q21 WIKI:CKS1B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15147722 PMID:11516665 References_end</body> </html> </notes> <label text="CKS1B"/> <bbox w="80.0" h="40.0" x="5869.0" y="3018.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s117_akt1_akt2_sa104"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> </notes> <label text="CUL1"/> <bbox w="80.0" h="40.0" x="5950.0" y="3018.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s116_akt1_akt2_sa105"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: S-phase kinase-associated protein 2 (p45) HUGO:SKP2 HGNC:10901 ENTREZ:6502 UNIPROT:Q13309 GENECARDS:SKP2 REACTOME:405589 KEGG:6502 ATLASONC:GC_SKP2 WIKI:SKP2 Q13309 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15147722 References_end</body> </html> </notes> <label text="SKP2"/> <bbox w="80.0" h="40.0" x="5950.0" y="3060.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s131_akt1_akt2_sa115"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 "S-phase kinase-associated protein 1A (p19A)", SKP1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 "S-phase kinase-associated protein 1A (p19A)", SKP1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 "S-phase kinase-associated protein 1A (p19A)", SKP1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> </notes> <label text="SKP1"/> <bbox w="80.0" h="40.0" x="5868.5" y="3060.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s120_akt1_akt2_csa17" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK4_6*:CyclinD*:p27KIP1* Identifiers_end References_begin: s_akt2_re51(MAP:survival): PMID:18414028 PMID:9106657 s_akt2_re38(MAP:survival): PMID:18636226 PMID:15147722 PMID:14536078 PMID:12459251 s_akt2_re136:(MAP:survival) PMID:11124803 PMID:12459251 References_end</body> </html> </notes> <label text="CDK4_6*:CyclinD*:p27KIP1*"/> <bbox w="103.0" h="157.0" x="5397.0" y="3364.0"/> <glyph class="macromolecule" id="akt1_akt2_s121_akt1_akt2_sa107"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 4 HUGO:CDK4 HGNC:1773 ENTREZ:1019 UNIPROT:P11802 GENECARDS:CDK4 REACTOME:68329 KEGG:1019 ATLASONC:CDK4ID238ch12q14 WIKI:CDK4 cyclin-dependent kinase 6 HUGO:CDK6 HGNC:1777 ENTREZ:1021 UNIPROT:Q00534 GENECARDS:CDK6 REACTOME:68335 KEGG:1021 ATLASONC:GC_CDK6 WIKI:CDK6 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 References_end</body> </html> </notes> <label text="CDK4_6*"/> <bbox w="80.0" h="40.0" x="5406.0" y="3369.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s122_akt1_akt2_sa108"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 References_end</body> </html> </notes> <label text="CyclinD*"/> <bbox w="80.0" h="40.0" x="5406.0" y="3410.0"/> <glyph class="state variable" id="_24e6215d-807d-4327-8ee2-c0b99de65d3a"> <state value="" variable="T286"/> <bbox w="30.0" h="10.0" x="5471.0" y="3405.2148"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s177_akt1_akt2_sa109"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27 Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="p27KIP1*"/> <bbox w="80.0" h="40.0" x="5406.0" y="3452.0"/> <glyph class="state variable" id="_79d7adc2-f5a9-470a-bd25-03b336c6d028"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5441.0" y="3447.0"/> </glyph> <glyph class="state variable" id="_be3703ea-50d7-4760-96d6-4f26cd4f123b"> <state value="P" variable="S157"/> <bbox w="35.0" h="10.0" x="5468.5" y="3447.0"/> </glyph> <glyph class="state variable" id="_99230387-1c49-40b1-ad4a-c6107ce9651c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5441.0" y="3487.0"/> </glyph> <glyph class="state variable" id="_9e6c8da0-fa4d-423a-9f91-4197d4ce686f"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5421.9316" y="3447.0"/> </glyph> <glyph class="state variable" id="_26e61e40-6a17-436e-be02-ba2d27915802"> <state value="" variable="S10"/> <bbox w="25.0" h="10.0" x="5393.5" y="3449.402"/> </glyph> <glyph class="state variable" id="_63a26450-778e-4323-862e-314a23b06585"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="5470.382" y="3487.0"/> </glyph> <glyph class="state variable" id="_049cd50b-8247-48d2-8a6d-d28c9d5a7b08"> <state value="" variable="T157"/> <bbox w="30.0" h="10.0" x="5467.582" y="3447.0"/> </glyph> <glyph class="state variable" id="_485a5a9e-bbfc-4a7a-9dfe-e82726b64b00"> <state value="" variable="T198"/> <bbox w="30.0" h="10.0" x="5391.0" y="3486.7224"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s124_akt1_akt2_csa18" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK4_6*:CyclinD*:p27KIP1* Identifiers_end References_begin: s_akt2_re51(MAP:survival): PMID:18414028 PMID:9106657 References_end</body> </html> </notes> <label text="CDK4_6*:CyclinD*:p27KIP1*"/> <bbox w="103.0" h="157.0" x="5672.0" y="2655.5"/> <glyph class="macromolecule" id="akt1_akt2_s125_akt1_akt2_sa110"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 4 HUGO:CDK4 HGNC:1773 ENTREZ:1019 UNIPROT:P11802 GENECARDS:CDK4 REACTOME:68329 KEGG:1019 ATLASONC:CDK4ID238ch12q14 WIKI:CDK4 cyclin-dependent kinase 6 HUGO:CDK6 HGNC:1777 ENTREZ:1021 UNIPROT:Q00534 GENECARDS:CDK6 REACTOME:68335 KEGG:1021 ATLASONC:GC_CDK6 WIKI:CDK6 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 References_end</body> </html> </notes> <label text="CDK4_6*"/> <bbox w="80.0" h="40.0" x="5681.0" y="2660.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s126_akt1_akt2_sa111"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 References_end</body> </html> </notes> <label text="CyclinD*"/> <bbox w="80.0" h="40.0" x="5683.0" y="2702.5"/> <glyph class="state variable" id="_45aa25e8-9c8e-44cc-9a3c-28717385fc27"> <state value="" variable="T286"/> <bbox w="30.0" h="10.0" x="5748.0" y="2697.7148"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s173_akt1_akt2_sa137"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27 Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="p27KIP1*"/> <bbox w="80.0" h="40.0" x="5682.0" y="2742.0"/> <glyph class="state variable" id="_bd17990c-731e-4c3a-8663-40884598ddfc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5717.0" y="2737.0"/> </glyph> <glyph class="state variable" id="_8854f3c3-2f9b-4d16-ada0-243bdfdf3354"> <state value="P" variable="S157"/> <bbox w="35.0" h="10.0" x="5744.5" y="2737.0"/> </glyph> <glyph class="state variable" id="_24669ac1-2621-4314-a1ea-b5842beb8f17"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5717.0" y="2777.0"/> </glyph> <glyph class="state variable" id="_cdd7cf15-a458-44d8-884d-ca55804b7e12"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="5697.9316" y="2737.0"/> </glyph> <glyph class="state variable" id="_b126cfb7-8773-4db0-a5c2-122be97292de"> <state value="" variable="S10"/> <bbox w="25.0" h="10.0" x="5669.5" y="2739.402"/> </glyph> <glyph class="state variable" id="_bfcecffc-b629-4435-94bb-b7055c7122c4"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="5746.382" y="2777.0"/> </glyph> <glyph class="state variable" id="_378be12a-95dc-4394-a60f-c8450c6dae51"> <state value="" variable="T157"/> <bbox w="30.0" h="10.0" x="5743.582" y="2737.0"/> </glyph> <glyph class="state variable" id="_b62f8ebc-5b05-46ad-b380-3872562c5ab5"> <state value="" variable="T198"/> <bbox w="30.0" h="10.0" x="5667.0" y="2776.7224"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s138_akt1_akt2_csa20" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK2:CyclinE* Identifiers_end References_begin: s_akt2_re55:(MAP:survival) PMID:14536078 References_end</body> </html> </notes> <label text="CDK2:CyclinE*"/> <bbox w="100.0" h="120.0" x="5973.5" y="3460.5"/> <glyph class="macromolecule" id="akt1_akt2_s140_akt1_akt2_sa122"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin E1 HUGO:CCNE1 HGNC:1589 ENTREZ:898 UNIPROT:P24864 GENECARDS:CCNE1 REACTOME:87225 KEGG:898 ATLASONC:GC_CCNE1 WIKI:CCNE1 cyclin E2 HUGO:CCNE2 HGNC:1590 ENTREZ:9134 UNIPROT:O96020 GENECARDS:CCNE2 REACTOME:87228 KEGG:9134 ATLASONC:GC_CCNE2 WIKI:CCNE2 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:cellcycle / MODULE:CYCLINE MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:15147722 PMID:14536078 References_end</body> </html> </notes> <label text="CyclinE*"/> <bbox w="80.0" h="40.0" x="5982.0" y="3466.5"/> <glyph class="state variable" id="_3669d0d0-edb9-47b6-9ed2-f556698b2224"> <state value="" variable="S384"/> <bbox w="30.0" h="10.0" x="6047.0" y="3461.7148"/> </glyph> <glyph class="state variable" id="_9b79d823-8a93-41f5-8621-f383e1283492"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5977.0" y="3501.5"/> </glyph> <glyph class="state variable" id="_eba6d74d-1e38-4e65-88b2-874a81231833"> <state value="P" variable="T380"/> <bbox w="35.0" h="10.0" x="5964.5" y="3461.5"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s139_akt1_akt2_sa123"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 2 HUGO:CDK2 HGNC:1771 ENTREZ:1017 UNIPROT:P24941 GENECARDS:CDK2 REACTOME:87018 KEGG:1017 ATLASONC:GC_CDK2 WIKI:CDK2 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:dnarepair / MODULE:S_CC_PHASE MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:15147722 PMID:14536078 References_end</body> </html> </notes> <label text="CDK2"/> <bbox w="80.0" h="40.0" x="5984.0" y="3508.5"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s141_akt1_akt2_csa21" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK2:CyclinE* Identifiers_end References_begin: s_akt2_re56:(MAP:survival) PMID:14536078 References_end</body> </html> </notes> <label text="CDK2:CyclinE*"/> <bbox w="100.0" h="120.0" x="6113.0" y="3460.5"/> <glyph class="macromolecule" id="akt1_akt2_s142_akt1_akt2_sa124"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 2 HUGO:CDK2 HGNC:1771 ENTREZ:1017 UNIPROT:P24941 GENECARDS:CDK2 REACTOME:87018 KEGG:1017 ATLASONC:GC_CDK2 WIKI:CDK2 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:dnarepair / MODULE:S_CC_PHASE MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:15147722 PMID:14536078 References_end</body> </html> </notes> <label text="CDK2"/> <bbox w="80.0" h="40.0" x="6123.5" y="3508.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s143_akt1_akt2_sa125"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin E1 HUGO:CCNE1 HGNC:1589 ENTREZ:898 UNIPROT:P24864 GENECARDS:CCNE1 REACTOME:87225 KEGG:898 ATLASONC:GC_CCNE1 WIKI:CCNE1 cyclin E2 HUGO:CCNE2 HGNC:1590 ENTREZ:9134 UNIPROT:O96020 GENECARDS:CCNE2 REACTOME:87228 KEGG:9134 ATLASONC:GC_CCNE2 WIKI:CCNE2 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:cellcycle / MODULE:CYCLINE MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:15147722 PMID:14536078 References_end</body> </html> </notes> <label text="CyclinE*"/> <bbox w="80.0" h="40.0" x="6121.5" y="3466.5"/> <glyph class="state variable" id="_60ebabc1-1076-4098-b74c-5ae2f41f9834"> <state value="P" variable="S384"/> <bbox w="35.0" h="10.0" x="6184.0" y="3461.7148"/> </glyph> <glyph class="state variable" id="_80e8a6c7-dc8a-47f9-b99e-7cc97645e76f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6116.5" y="3501.5"/> </glyph> <glyph class="state variable" id="_7d1d5530-9560-42d0-b101-40abffb35a9a"> <state value="P" variable="T380"/> <bbox w="35.0" h="10.0" x="6104.0" y="3461.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s150_akt1_akt2_csa22" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK2:CyclinE* Identifiers_end</body> </html> </notes> <label text="CDK2:CyclinE*"/> <bbox w="100.0" h="120.0" x="6244.5" y="3460.5"/> <glyph class="macromolecule" id="akt1_akt2_s151_akt1_akt2_sa129"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 2 HUGO:CDK2 HGNC:1771 ENTREZ:1017 UNIPROT:P24941 GENECARDS:CDK2 REACTOME:87018 KEGG:1017 ATLASONC:GC_CDK2 WIKI:CDK2 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:dnarepair / MODULE:S_CC_PHASE MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:15147722 PMID:14536078 References_end</body> </html> </notes> <label text="CDK2"/> <bbox w="80.0" h="40.0" x="6255.0" y="3516.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s152_akt1_akt2_sa130"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin E1 HUGO:CCNE1 HGNC:1589 ENTREZ:898 UNIPROT:P24864 GENECARDS:CCNE1 REACTOME:87225 KEGG:898 ATLASONC:GC_CCNE1 WIKI:CCNE1 cyclin E2 HUGO:CCNE2 HGNC:1590 ENTREZ:9134 UNIPROT:O96020 GENECARDS:CCNE2 REACTOME:87228 KEGG:9134 ATLASONC:GC_CCNE2 WIKI:CCNE2 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:cellcycle / MODULE:CYCLINE MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:15147722 PMID:14536078 References_end</body> </html> </notes> <label text="CyclinE*"/> <bbox w="80.0" h="40.0" x="6252.0" y="3473.5"/> <glyph class="state variable" id="_ee1ca473-2b59-4968-8616-df8b2e674c97"> <state value="P" variable="S384"/> <bbox w="35.0" h="10.0" x="6314.5" y="3468.7148"/> </glyph> <glyph class="state variable" id="_81315a37-8bdf-43f3-99d7-bc28cf3eff82"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="6242.0" y="3508.5"/> </glyph> <glyph class="state variable" id="_a1608873-fb5d-446b-9801-ea1a5697c79b"> <state value="P" variable="T380"/> <bbox w="35.0" h="10.0" x="6234.5" y="3468.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s159_akt1_akt2_csa19" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDC53*:RBX1:SKP1:SKP2 Identifiers_end</body> </html> </notes> <label text="CDC53*:RBX1:SKP1:SKP2"/> <bbox w="173.0" h="117.0" x="5397.0" y="3544.0"/> <glyph class="macromolecule" id="akt1_akt2_s129_akt1_akt2_sa113"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> </notes> <label text="RBX1"/> <bbox w="80.0" h="40.0" x="5402.0" y="3551.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s130_akt1_akt2_sa114"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 "S-phase kinase-associated protein 1A (p19A)", SKP1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 "S-phase kinase-associated protein 1A (p19A)", SKP1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 "S-phase kinase-associated protein 1A (p19A)", SKP1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> </notes> <label text="SKP1"/> <bbox w="80.0" h="40.0" x="5403.0" y="3592.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s132_akt1_akt2_sa116"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ring finger protein 7 HUGO:RNF7 HGNC:10070 ENTREZ:9616 UNIPROT:Q9UBF6 GENECARDS:RNF7 KEGG:9616 ATLASONC:RNF7ID44108ch3q22 WIKI:RNF7 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11554450 PMID:15147722 References_end</body> </html> </notes> <label text="CDC53*"/> <bbox w="80.0" h="40.0" x="5484.0" y="3552.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s134_akt1_akt2_sa118"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: S-phase kinase-associated protein 2 (p45) HUGO:SKP2 HGNC:10901 ENTREZ:6502 UNIPROT:Q13309 GENECARDS:SKP2 REACTOME:405589 KEGG:6502 ATLASONC:GC_SKP2 WIKI:SKP2 Q13309 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15147722 References_end</body> </html> </notes> <label text="SKP2"/> <bbox w="80.0" h="40.0" x="5481.0" y="3591.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s160_akt1_akt2_csa23" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDC53*:FBW7*:RBX1:SKP1 Identifiers_end</body> </html> </notes> <label text="CDC53*:FBW7*:RBX1:SKP1"/> <bbox w="186.0" h="114.0" x="5943.5" y="3661.0"/> <glyph class="macromolecule" id="akt1_akt2_s154_akt1_akt2_sa131"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> </notes> <label text="RBX1"/> <bbox w="80.0" h="40.0" x="5948.5" y="3668.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s155_akt1_akt2_sa132"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 "S-phase kinase-associated protein 1A (p19A)", SKP1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 "S-phase kinase-associated protein 1A (p19A)", SKP1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 "S-phase kinase-associated protein 1A (p19A)", SKP1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> </notes> <label text="SKP1"/> <bbox w="80.0" h="40.0" x="5949.5" y="3709.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s156_akt1_akt2_sa133"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ring finger protein 7 HUGO:RNF7 HGNC:10070 ENTREZ:9616 UNIPROT:Q9UBF6 GENECARDS:RNF7 KEGG:9616 ATLASONC:RNF7ID44108ch3q22 WIKI:RNF7 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11554450 PMID:15147722 References_end</body> </html> </notes> <label text="CDC53*"/> <bbox w="80.0" h="40.0" x="6030.5" y="3669.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s158_akt1_akt2_sa136"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: F-box and WD repeat domain containing 7 HUGO:FBXW7 HGNC:16712 ENTREZ:55294 UNIPROT:Q969H0 GENECARDS:FBXW7 REACTOME:147220 KEGG:55294 ATLASONC:GC_FBXW7 WIKI:FBXW7 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:15147722 PMID:14536078 References_end</body> </html> </notes> <label text="FBW7*"/> <bbox w="80.0" h="40.0" x="6033.0" y="3709.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s207_akt1_akt2_csa26" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FOXO3:promoter_region Identifiers_end References_begin: s_akt2_re80:(MAP:survival) PMID15084260 References_end</body> </html> </notes> <label text="FOXO3:promoter_region"/> <bbox w="100.0" h="110.0" x="5017.0" y="3164.0"/> <glyph class="macromolecule" id="akt1_akt2_s209_akt1_akt2_sa164"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 GENECARDS:FOXO3 REACTOME:199273 KEGG:2309 ATLASONC:AF6q21ID125 WIKI:FOXO3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16288288 PMID:17646672 References_end</body> </html> </notes> <label text="FOXO3"/> <bbox w="80.0" h="40.0" x="5024.5" y="3175.5"/> <glyph class="state variable" id="_26cbeda6-6888-4b3b-bf4b-5363e570916f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5059.5" y="3170.5"/> </glyph> <glyph class="state variable" id="_f0199e80-393a-4d96-9a83-4ae44100427d"> <state value="P" variable="S644"/> <bbox w="35.0" h="10.0" x="5007.0" y="3210.2224"/> </glyph> <glyph class="state variable" id="_7b2418e8-0b3f-42e9-8576-aa58a335988e"> <state value="" variable="T32"/> <bbox w="25.0" h="10.0" x="5012.0" y="3171.4302"/> </glyph> <glyph class="state variable" id="_9558ee03-a6e0-4345-8da5-4597404fc053"> <state value="" variable="S253"/> <bbox w="30.0" h="10.0" x="5089.5" y="3209.6306"/> </glyph> <glyph class="state variable" id="_47cca102-ec17-4ad2-813f-7eeb3f1819c0"> <state value="" variable="S315"/> <bbox w="30.0" h="10.0" x="5086.082" y="3170.5"/> </glyph> <glyph class="state variable" id="_5446a142-4007-46fa-b7f6-57d75f8d7d28"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5019.5" y="3190.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_akt2_s208_akt1_akt2_sa165"> <label text="promoter_region"/> <bbox w="70.0" h="25.0" x="5031.0" y="3224.5"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s195_akt1_akt2_csa25" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FOXO4:promoter_region Identifiers_end References_begin: s_akt2_re1:(MAP:survival) PMID:10783894 PMID:20673124 PMID:11094066 PMID:11994454 s_akt2_re61(MAP:survival): PMID15509806 PMID20673124 s_akt2_re79(MAP:survival): PMID:17646672 s_akt2_re86:(MAP:survival) PMID:15509806 PMID:20673124 References_end</body> </html> </notes> <label text="FOXO4:promoter_region"/> <bbox w="105.0" h="101.0" x="4944.0" y="3494.0"/> <glyph class="macromolecule" id="akt1_akt2_s223_akt1_akt2_sa2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: forkhead box O4 HUGO:FOXO4 HGNC:7139 ENTREZ:4303 UNIPROT:P98177 GENECARDS:FOXO4 REACTOME:404982 KEGG:4303 ATLASONC:AFX1ID57 WIKI:FOXO4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11313479 PMID:10217147 PMID:12391153 References_end</body> </html> </notes> <label text="FOXO4"/> <bbox w="80.0" h="40.0" x="4953.3335" y="3504.0"/> <glyph class="state variable" id="_78fe67f1-727c-43e4-9b8f-24ca4cc231d6"> <state value="" variable="S193"/> <bbox w="30.0" h="10.0" x="5018.3335" y="3499.2148"/> </glyph> <glyph class="state variable" id="_683e6f82-5dcf-4986-b7d1-3c0aa03933c5"> <state value="" variable="S258"/> <bbox w="30.0" h="10.0" x="5017.7153" y="3539.0"/> </glyph> <glyph class="state variable" id="_199283f0-b688-48f9-b076-4fac49ff34c7"> <state value="" variable="T28"/> <bbox w="25.0" h="10.0" x="4941.326" y="3499.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_akt2_s224_akt1_akt2_sa153"> <label text="promoter_region"/> <bbox w="70.0" h="25.0" x="4955.5" y="3553.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s228_akt1_akt2_csa28" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FOXO1:promoter_region Identifiers_end References_begin: s_akt2_re1:(MAP:survival) PMID:10783894 PMID:20673124 PMID:11094066 PMID:11994454 s_akt2_re89:(MAP:survival) PMID:17646672 s_akt2_re93:(MAP:survival) PMID19244250 References_end</body> </html> </notes> <label text="FOXO1:promoter_region"/> <bbox w="105.0" h="101.0" x="4956.0" y="3311.5"/> <glyph class="macromolecule" id="akt1_akt2_s230_akt1_akt2_sa179"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end</body> </html> </notes> <label text="FOXO1"/> <bbox w="80.0" h="40.0" x="4967.25" y="3319.0"/> <glyph class="state variable" id="_919e801e-77bd-4dfe-b237-1c11369a63b3"> <state value="" variable="S329"/> <bbox w="30.0" h="10.0" x="4952.25" y="3353.7224"/> </glyph> <glyph class="state variable" id="_39b8158c-d4e6-4b80-a622-304ebdef835a"> <state value="" variable="S319"/> <bbox w="30.0" h="10.0" x="5032.25" y="3314.0"/> </glyph> <glyph class="state variable" id="_d23fbb76-519f-4426-9efc-4f62ca2fc47b"> <state value="" variable="S325"/> <bbox w="30.0" h="10.0" x="4992.1543" y="3354.0"/> </glyph> <glyph class="state variable" id="_80a3322d-4c02-4d81-b1d4-57876509434b"> <state value="" variable="S322"/> <bbox w="30.0" h="10.0" x="5031.632" y="3354.0"/> </glyph> <glyph class="state variable" id="_d78db8d5-9ba3-424b-ab8c-5b65da6171fa"> <state value="" variable="S256"/> <bbox w="30.0" h="10.0" x="4992.2817" y="3314.0"/> </glyph> <glyph class="state variable" id="_fc86da77-6f01-451c-8335-8358d16b183c"> <state value="" variable="T24"/> <bbox w="25.0" h="10.0" x="4955.2427" y="3314.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_akt2_s229_akt1_akt2_sa178"> <label text="promoter_region"/> <bbox w="70.0" h="25.0" x="4973.25" y="3364.5"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s231_akt1_akt2_csa29" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FOXO1:promoter_region Identifiers_end References_begin: s_akt2_re89:(MAP:survival) PMID:17646672 s_akt2_re104:(MAP:survival) PMID:15668399 References_end</body> </html> </notes> <label text="FOXO1:promoter_region"/> <bbox w="105.0" h="101.0" x="4967.5" y="3957.5"/> <glyph class="macromolecule" id="akt1_akt2_s233_akt1_akt2_sa181"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end</body> </html> </notes> <label text="FOXO1"/> <bbox w="80.0" h="40.0" x="4978.75" y="3965.0"/> <glyph class="state variable" id="_208776b7-47a8-4dc6-9e6b-42773562640e"> <state value="" variable="S329"/> <bbox w="30.0" h="10.0" x="4963.75" y="3999.7224"/> </glyph> <glyph class="state variable" id="_d2746107-4c6b-4435-8e92-2fcacd7c5840"> <state value="P" variable="S319"/> <bbox w="35.0" h="10.0" x="5041.25" y="3960.0"/> </glyph> <glyph class="state variable" id="_ef7fb61a-f531-429d-a446-dc2dd943121c"> <state value="" variable="S325"/> <bbox w="30.0" h="10.0" x="5003.6543" y="4000.0"/> </glyph> <glyph class="state variable" id="_bf5c8ed4-e4f4-4548-9ec8-f7b69fac8a60"> <state value="" variable="S322"/> <bbox w="30.0" h="10.0" x="5043.132" y="4000.0"/> </glyph> <glyph class="state variable" id="_81cb87a5-095b-46f1-96c0-23bec44f905b"> <state value="P" variable="S256"/> <bbox w="35.0" h="10.0" x="5001.2817" y="3960.0"/> </glyph> <glyph class="state variable" id="_241d4822-a769-4cb3-928a-7880c40cbf44"> <state value="P" variable="T24"/> <bbox w="30.0" h="10.0" x="4964.2427" y="3960.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_akt2_s232_akt1_akt2_sa180"> <label text="promoter_region"/> <bbox w="70.0" h="25.0" x="4984.75" y="4010.5"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s258_akt1_akt2_csa30" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CRM1*:FOXO4 Identifiers_end References_begin: s_akt2_re108:(MAP:survival) PMID:11313479 References_end</body> </html> </notes> <label text="CRM1*:FOXO4"/> <bbox w="100.0" h="120.0" x="4689.0" y="3759.0"/> <glyph class="macromolecule" id="akt1_akt2_s259_akt1_akt2_sa207"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> </notes> <label text="CRM1*"/> <bbox w="80.0" h="40.0" x="4699.5" y="3765.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s260_akt1_akt2_sa208"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: forkhead box O4 HUGO:FOXO4 HGNC:7139 ENTREZ:4303 UNIPROT:P98177 GENECARDS:FOXO4 REACTOME:404982 KEGG:4303 ATLASONC:AFX1ID57 WIKI:FOXO4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11313479 PMID:10217147 PMID:12391153 References_end</body> </html> </notes> <label text="FOXO4"/> <bbox w="80.0" h="40.0" x="4700.5" y="3806.0"/> <glyph class="state variable" id="_b700306b-81ef-47df-9d96-07e16e9d2797"> <state value="" variable="S193"/> <bbox w="30.0" h="10.0" x="4765.5" y="3801.2148"/> </glyph> <glyph class="state variable" id="_0a1615cd-0a9e-4886-8615-c1ce3a278cd5"> <state value="" variable="S258"/> <bbox w="30.0" h="10.0" x="4764.882" y="3841.0"/> </glyph> <glyph class="state variable" id="_b9a44293-9641-452b-b805-3982129d7b83"> <state value="" variable="T28"/> <bbox w="25.0" h="10.0" x="4688.4927" y="3801.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s261_akt1_akt2_csa31" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CRM1*:FOXO4 Identifiers_end References_begin: s_akt2_re109:(MAP:survival) PMID:11313479 References_end</body> </html> </notes> <label text="CRM1*:FOXO4"/> <bbox w="100.0" h="120.0" x="4404.5" y="3760.0"/> <glyph class="macromolecule" id="akt1_akt2_s262_akt1_akt2_sa209"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> </notes> <label text="CRM1*"/> <bbox w="80.0" h="40.0" x="4415.0" y="3766.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s263_akt1_akt2_sa210"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: forkhead box O4 HUGO:FOXO4 HGNC:7139 ENTREZ:4303 UNIPROT:P98177 GENECARDS:FOXO4 REACTOME:404982 KEGG:4303 ATLASONC:AFX1ID57 WIKI:FOXO4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11313479 PMID:10217147 PMID:12391153 References_end</body> </html> </notes> <label text="FOXO4"/> <bbox w="80.0" h="40.0" x="4416.0" y="3807.0"/> <glyph class="state variable" id="_32e39fc8-6edd-47c9-a941-efabf3327620"> <state value="" variable="S193"/> <bbox w="30.0" h="10.0" x="4481.0" y="3802.2148"/> </glyph> <glyph class="state variable" id="_35f73863-2ca1-4ad6-bb83-aa40da102036"> <state value="" variable="S258"/> <bbox w="30.0" h="10.0" x="4480.382" y="3842.0"/> </glyph> <glyph class="state variable" id="_a4f62bcf-cb5c-4fa3-9cf8-029886d498d9"> <state value="" variable="T28"/> <bbox w="25.0" h="10.0" x="4403.9927" y="3802.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s266_akt1_akt2_csa32" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FOXO4:IMPORTIN* Identifiers_end References_begin: s_akt2_re114:(MAP:survival) PMID:11313479 References_end</body> </html> </notes> <label text="FOXO4:IMPORTIN*"/> <bbox w="100.0" h="120.0" x="4402.0" y="3285.0"/> <glyph class="macromolecule" id="akt1_akt2_s271_akt1_akt2_sa212"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: forkhead box O4 HUGO:FOXO4 HGNC:7139 ENTREZ:4303 UNIPROT:P98177 GENECARDS:FOXO4 REACTOME:404982 KEGG:4303 ATLASONC:AFX1ID57 WIKI:FOXO4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11313479 PMID:10217147 PMID:12391153 References_end</body> </html> </notes> <label text="FOXO4"/> <bbox w="80.0" h="40.0" x="4410.5" y="3295.0"/> <glyph class="state variable" id="_cff6bbb9-73d1-4d27-b374-9d7f6a5f666f"> <state value="" variable="S193"/> <bbox w="30.0" h="10.0" x="4475.5" y="3290.2148"/> </glyph> <glyph class="state variable" id="_91ace9af-bbfd-41cc-a2bc-2dfacb4ec99c"> <state value="" variable="S258"/> <bbox w="30.0" h="10.0" x="4474.882" y="3330.0"/> </glyph> <glyph class="state variable" id="_a86f9b66-a1c6-49f7-b406-2ae491b32859"> <state value="" variable="T28"/> <bbox w="25.0" h="10.0" x="4398.4927" y="3290.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s272_akt1_akt2_sa215"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: importin 4 HUGO:IPO4 HGNC:19426 ENTREZ:79711 UNIPROT:Q8TEX9 GENECARDS:IPO4 KEGG:79711 ATLASONC:GC_IPO4 WIKI:IPO4 importin 5 HUGO:IPO5 HGNC:6402 ENTREZ:3843 UNIPROT:O00410 GENECARDS:IPO5 REACTOME:57347 KEGG:3843 ATLASONC:GC_IPO5 WIKI:IPO5 importin 7 HUGO:IPO7 HGNC:9852 ENTREZ:10527 UNIPROT:O95373 GENECARDS:IPO7 KEGG:10527 ATLASONC:GC_IPO7 WIKI:IPO7 importin 8 HUGO:IPO8 HGNC:9853 ENTREZ:10526 UNIPROT:O15397 GENECARDS:IPO8 KEGG:10526 ATLASONC:GC_IPO8 WIKI:IPO8 importin 9 HUGO:IPO9 HGNC:19425 ENTREZ:55705 UNIPROT:Q96P70 GENECARDS:IPO9 KEGG:55705 WIKI:IPO9 importin 11 HUGO:IPO11 HGNC:20628 ENTREZ:51194 UNIPROT:Q9UI26 GENECARDS:IPO11 KEGG:51194 ATLASONC:GC_IPO11 WIKI:IPO11 importin 13 HUGO:IPO13 HGNC:16853 ENTREZ:9670 UNIPROT:O94829 GENECARDS:IPO13 KEGG:9670 ATLASONC:GC_IPO13 WIKI:IPO13 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11313479 PMID:10217147 PMID:12391153 References_end</body> </html> </notes> <label text="IMPORTIN*"/> <bbox w="80.0" h="40.0" x="4409.5" y="3339.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s270_akt1_akt2_csa33" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FOXO4:IMPORTIN* Identifiers_end References_begin: s_akt2_re111:(MAP:survival) PMID:11313479 References_end</body> </html> </notes> <label text="FOXO4:IMPORTIN*"/> <bbox w="100.0" h="120.0" x="4683.5" y="3414.0"/> <glyph class="macromolecule" id="akt1_akt2_s267_akt1_akt2_sa216"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: forkhead box O4 HUGO:FOXO4 HGNC:7139 ENTREZ:4303 UNIPROT:P98177 GENECARDS:FOXO4 REACTOME:404982 KEGG:4303 ATLASONC:AFX1ID57 WIKI:FOXO4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11313479 PMID:10217147 PMID:12391153 References_end</body> </html> </notes> <label text="FOXO4"/> <bbox w="80.0" h="40.0" x="4692.0" y="3424.0"/> <glyph class="state variable" id="_4a7cf216-825f-43a3-a0cf-780c4e8628eb"> <state value="" variable="S193"/> <bbox w="30.0" h="10.0" x="4757.0" y="3419.2148"/> </glyph> <glyph class="state variable" id="_ab01c4fe-66bb-4bf8-8029-9ad78bf332d8"> <state value="" variable="S258"/> <bbox w="30.0" h="10.0" x="4756.382" y="3459.0"/> </glyph> <glyph class="state variable" id="_51acfbff-2e28-4858-85c5-8e83e0141774"> <state value="" variable="T28"/> <bbox w="25.0" h="10.0" x="4679.9927" y="3419.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s269_akt1_akt2_sa217"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: importin 4 HUGO:IPO4 HGNC:19426 ENTREZ:79711 UNIPROT:Q8TEX9 GENECARDS:IPO4 KEGG:79711 ATLASONC:GC_IPO4 WIKI:IPO4 importin 5 HUGO:IPO5 HGNC:6402 ENTREZ:3843 UNIPROT:O00410 GENECARDS:IPO5 REACTOME:57347 KEGG:3843 ATLASONC:GC_IPO5 WIKI:IPO5 importin 7 HUGO:IPO7 HGNC:9852 ENTREZ:10527 UNIPROT:O95373 GENECARDS:IPO7 KEGG:10527 ATLASONC:GC_IPO7 WIKI:IPO7 importin 8 HUGO:IPO8 HGNC:9853 ENTREZ:10526 UNIPROT:O15397 GENECARDS:IPO8 KEGG:10526 ATLASONC:GC_IPO8 WIKI:IPO8 importin 9 HUGO:IPO9 HGNC:19425 ENTREZ:55705 UNIPROT:Q96P70 GENECARDS:IPO9 KEGG:55705 WIKI:IPO9 importin 11 HUGO:IPO11 HGNC:20628 ENTREZ:51194 UNIPROT:Q9UI26 GENECARDS:IPO11 KEGG:51194 ATLASONC:GC_IPO11 WIKI:IPO11 importin 13 HUGO:IPO13 HGNC:16853 ENTREZ:9670 UNIPROT:O94829 GENECARDS:IPO13 KEGG:9670 ATLASONC:GC_IPO13 WIKI:IPO13 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11313479 PMID:10217147 PMID:12391153 References_end</body> </html> </notes> <label text="IMPORTIN*"/> <bbox w="80.0" h="40.0" x="4690.0" y="3472.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s277_akt1_akt2_csa34" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CRM1*:FOXO4 Identifiers_end References_begin: s_akt2_re115:(MAP:survival) PMID:11313479 References_end</body> </html> </notes> <label text="CRM1*:FOXO4"/> <bbox w="100.0" h="120.0" x="4689.0" y="3895.0"/> <glyph class="macromolecule" id="akt1_akt2_s278_akt1_akt2_sa220"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: forkhead box O4 HUGO:FOXO4 HGNC:7139 ENTREZ:4303 UNIPROT:P98177 GENECARDS:FOXO4 REACTOME:404982 KEGG:4303 ATLASONC:AFX1ID57 WIKI:FOXO4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11313479 PMID:10217147 PMID:12391153 References_end</body> </html> </notes> <label text="FOXO4"/> <bbox w="80.0" h="40.0" x="4696.5" y="3907.0"/> <glyph class="state variable" id="_b0979303-cad8-4c88-a6a7-92aa37a4d9a1"> <state value="P" variable="S193"/> <bbox w="35.0" h="10.0" x="4759.0" y="3902.2148"/> </glyph> <glyph class="state variable" id="_d5c4179b-784c-4cc9-9582-a316bd7d007c"> <state value="P" variable="S258"/> <bbox w="35.0" h="10.0" x="4758.382" y="3942.0"/> </glyph> <glyph class="state variable" id="_7a181ae4-a591-404d-b6cd-afbeb91430a1"> <state value="P" variable="T28"/> <bbox w="30.0" h="10.0" x="4681.9927" y="3902.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s279_akt1_akt2_sa221"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> </notes> <label text="CRM1*"/> <bbox w="80.0" h="40.0" x="4696.5" y="3952.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s280_akt1_akt2_csa35" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CRM1*:FOXO4 Identifiers_end References_begin: s_akt2_re116:(MAP:survival) PMID:11313479 References_end</body> </html> </notes> <label text="CRM1*:FOXO4"/> <bbox w="100.0" h="120.0" x="4405.5" y="3898.0"/> <glyph class="macromolecule" id="akt1_akt2_s281_akt1_akt2_sa222"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: forkhead box O4 HUGO:FOXO4 HGNC:7139 ENTREZ:4303 UNIPROT:P98177 GENECARDS:FOXO4 REACTOME:404982 KEGG:4303 ATLASONC:AFX1ID57 WIKI:FOXO4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11313479 PMID:10217147 PMID:12391153 References_end</body> </html> </notes> <label text="FOXO4"/> <bbox w="80.0" h="40.0" x="4413.0" y="3910.0"/> <glyph class="state variable" id="_5c2ec8b2-a42f-452d-96ef-a04dc123d2bb"> <state value="P" variable="S193"/> <bbox w="35.0" h="10.0" x="4475.5" y="3905.2148"/> </glyph> <glyph class="state variable" id="_f0e45126-3002-4e1a-ab8b-984206eb5b0e"> <state value="P" variable="S258"/> <bbox w="35.0" h="10.0" x="4474.882" y="3945.0"/> </glyph> <glyph class="state variable" id="_84afd6de-e984-474e-80db-d9829ebc9545"> <state value="P" variable="T28"/> <bbox w="30.0" h="10.0" x="4398.4927" y="3905.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s282_akt1_akt2_sa223"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> </notes> <label text="CRM1*"/> <bbox w="80.0" h="40.0" x="4413.0" y="3955.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s286_akt1_akt2_csa36" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:FOXO1 Identifiers_end References_begin: s_akt2_re118:(MAP:survival) PMID:14664696 References_end</body> </html> </notes> <label text="14-3-3*:FOXO1"/> <bbox w="100.0" h="120.0" x="4698.0" y="4178.0"/> <glyph class="macromolecule" id="akt1_akt2_s301_akt1_akt2_sa229"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end</body> </html> </notes> <label text="FOXO1"/> <bbox w="80.0" h="40.0" x="4707.875" y="4189.0"/> <glyph class="state variable" id="_09f6bbee-4708-4088-931d-ae8f43412a83"> <state value="" variable="S329"/> <bbox w="30.0" h="10.0" x="4692.875" y="4223.722"/> </glyph> <glyph class="state variable" id="_67692266-e28f-411d-92cb-69f6088b0722"> <state value="P" variable="S319"/> <bbox w="35.0" h="10.0" x="4770.375" y="4184.0"/> </glyph> <glyph class="state variable" id="_91110d2d-8b11-4146-8ac3-eb961a16d626"> <state value="" variable="S325"/> <bbox w="30.0" h="10.0" x="4732.7793" y="4224.0"/> </glyph> <glyph class="state variable" id="_42824208-548a-4e0d-86f6-ef59d0a7d921"> <state value="" variable="S322"/> <bbox w="30.0" h="10.0" x="4772.257" y="4224.0"/> </glyph> <glyph class="state variable" id="_3ca2691b-4761-4710-ba6f-b016ef133b75"> <state value="P" variable="S256"/> <bbox w="35.0" h="10.0" x="4730.4067" y="4184.0"/> </glyph> <glyph class="state variable" id="_2dce9388-e3e4-4355-ac3e-7b18c0a3d1b7"> <state value="P" variable="T24"/> <bbox w="30.0" h="10.0" x="4693.3677" y="4184.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s293_akt1_akt2_sa230"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="4708.125" y="4234.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s294_akt1_akt2_csa37" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:FOXO1 Identifiers_end References_begin: s_akt2_re119:(MAP:survival) PMID:14664696 References_end</body> </html> </notes> <label text="14-3-3*:FOXO1"/> <bbox w="100.0" h="120.0" x="4414.5" y="4370.0"/> <glyph class="macromolecule" id="akt1_akt2_s302_akt1_akt2_sa231"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end</body> </html> </notes> <label text="FOXO1"/> <bbox w="80.0" h="40.0" x="4421.0" y="4380.0"/> <glyph class="state variable" id="_2a66c769-ac31-4071-843c-015cdd592bbd"> <state value="" variable="S329"/> <bbox w="30.0" h="10.0" x="4406.0" y="4414.722"/> </glyph> <glyph class="state variable" id="_fc9f8946-6e7c-42b3-8ed3-c0cf373baf00"> <state value="P" variable="S319"/> <bbox w="35.0" h="10.0" x="4483.5" y="4375.0"/> </glyph> <glyph class="state variable" id="_3b14ee9b-0145-4fa0-aa4d-5397e882db4e"> <state value="" variable="S325"/> <bbox w="30.0" h="10.0" x="4445.9043" y="4415.0"/> </glyph> <glyph class="state variable" id="_89b8d3a8-40c7-4876-a4b3-a3ffc611a3cc"> <state value="" variable="S322"/> <bbox w="30.0" h="10.0" x="4485.382" y="4415.0"/> </glyph> <glyph class="state variable" id="_02f0b493-1326-4a56-a5ad-810140e794b1"> <state value="P" variable="S256"/> <bbox w="35.0" h="10.0" x="4443.5317" y="4375.0"/> </glyph> <glyph class="state variable" id="_a6e0bae2-2d1a-4383-acc7-655f4a351670"> <state value="P" variable="T24"/> <bbox w="30.0" h="10.0" x="4406.4927" y="4375.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s296_akt1_akt2_sa232"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="4421.0" y="4425.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s311_akt1_akt2_csa38" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CRM1*:FOXO1 Identifiers_end References_begin: s_akt2_re123:(MAP:survival) PMID:11980723 PMID:14664696 References_end</body> </html> </notes> <label text="CRM1*:FOXO1"/> <bbox w="100.0" h="120.0" x="4709.0" y="4446.0"/> <glyph class="macromolecule" id="akt1_akt2_s316_akt1_akt2_sa237"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end</body> </html> </notes> <label text="FOXO1"/> <bbox w="80.0" h="40.0" x="4717.25" y="4456.0"/> <glyph class="state variable" id="_7f93252f-0721-40c5-bcb8-f3329a23e193"> <state value="P" variable="S329"/> <bbox w="35.0" h="10.0" x="4699.75" y="4490.722"/> </glyph> <glyph class="state variable" id="_bcb05ec9-490f-403a-9024-4cab6a70d0d0"> <state value="P" variable="S319"/> <bbox w="35.0" h="10.0" x="4779.75" y="4451.0"/> </glyph> <glyph class="state variable" id="_330462c8-4d68-4895-b912-c8991b1d7ed1"> <state value="P" variable="S325"/> <bbox w="35.0" h="10.0" x="4739.6543" y="4491.0"/> </glyph> <glyph class="state variable" id="_5ca1ae3d-a105-4984-8bd9-b7d97c83e5dc"> <state value="P" variable="S322"/> <bbox w="35.0" h="10.0" x="4779.132" y="4491.0"/> </glyph> <glyph class="state variable" id="_b323605c-0d30-4f23-ba30-b3162b61e810"> <state value="P" variable="S256"/> <bbox w="35.0" h="10.0" x="4739.7817" y="4451.0"/> </glyph> <glyph class="state variable" id="_ac8e6fb4-f64e-4d10-8f26-db0d3d303913"> <state value="P" variable="T24"/> <bbox w="30.0" h="10.0" x="4702.7427" y="4451.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s321_akt1_akt2_sa238"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> </notes> <label text="CRM1*"/> <bbox w="80.0" h="40.0" x="4717.25" y="4504.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s325_akt1_akt2_csa39" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CRM1*:FOXO1 Identifiers_end References_begin: s_akt2_re124:(MAP:survival) PMID:11980723 PMID:14664696 References_end</body> </html> </notes> <label text="CRM1*:FOXO1"/> <bbox w="100.0" h="120.0" x="5073.0" y="4829.0"/> <glyph class="macromolecule" id="akt1_akt2_s326_akt1_akt2_sa239"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> </notes> <label text="CRM1*"/> <bbox w="80.0" h="40.0" x="5081.25" y="4887.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s327_akt1_akt2_sa240"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end</body> </html> </notes> <label text="FOXO1"/> <bbox w="80.0" h="40.0" x="5081.25" y="4839.0"/> <glyph class="state variable" id="_0e38bd7f-e2b1-42f6-839a-6759a32a1b84"> <state value="P" variable="S329"/> <bbox w="35.0" h="10.0" x="5063.75" y="4873.722"/> </glyph> <glyph class="state variable" id="_e66a254a-e5ba-417f-b003-6820024f1086"> <state value="P" variable="S319"/> <bbox w="35.0" h="10.0" x="5143.75" y="4834.0"/> </glyph> <glyph class="state variable" id="_38ad8076-cf73-473f-b03d-1a43c89b3294"> <state value="P" variable="S325"/> <bbox w="35.0" h="10.0" x="5103.6543" y="4874.0"/> </glyph> <glyph class="state variable" id="_2bdbda3a-7b74-4623-bc1e-059238e1e0ae"> <state value="P" variable="S322"/> <bbox w="35.0" h="10.0" x="5143.132" y="4874.0"/> </glyph> <glyph class="state variable" id="_82061162-316c-4725-a9c0-9a7b91517cd8"> <state value="P" variable="S256"/> <bbox w="35.0" h="10.0" x="5103.7817" y="4834.0"/> </glyph> <glyph class="state variable" id="_e57253e9-1916-4c77-bc2b-8530007af009"> <state value="P" variable="T24"/> <bbox w="30.0" h="10.0" x="5066.7427" y="4834.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s328_akt1_akt2_csa40" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:FOXO4 Identifiers_end</body> </html> </notes> <label text="14-3-3*:FOXO4"/> <bbox w="100.0" h="120.0" x="4420.0" y="4201.0"/> <glyph class="macromolecule" id="akt1_akt2_s333_akt1_akt2_sa241"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: forkhead box O4 HUGO:FOXO4 HGNC:7139 ENTREZ:4303 UNIPROT:P98177 GENECARDS:FOXO4 REACTOME:404982 KEGG:4303 ATLASONC:AFX1ID57 WIKI:FOXO4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11313479 PMID:10217147 PMID:12391153 References_end</body> </html> </notes> <label text="FOXO4"/> <bbox w="80.0" h="40.0" x="4429.25" y="4215.0"/> <glyph class="state variable" id="_b3031006-d3b8-483c-923b-5142cd3ae2fd"> <state value="P" variable="S193"/> <bbox w="35.0" h="10.0" x="4491.75" y="4210.215"/> </glyph> <glyph class="state variable" id="_dcf0c772-ee60-4d74-b790-1b1e6411b788"> <state value="P" variable="S258"/> <bbox w="35.0" h="10.0" x="4491.132" y="4250.0"/> </glyph> <glyph class="state variable" id="_00a3ba76-8337-4e14-8c95-8ab2041ec670"> <state value="P" variable="T28"/> <bbox w="30.0" h="10.0" x="4414.7427" y="4210.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s338_akt1_akt2_sa242"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="4429.5" y="4259.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s345_akt1_akt2_csa41" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CKS1B:CUL1:SKP1:SKP2 Identifiers_end References_begin: s_akt2_re91:(MAP:survival) PMID:15668399 References_end</body> </html> </notes> <label text="CKS1B:CUL1:SKP1:SKP2"/> <bbox w="172.0" h="112.0" x="4765.25" y="4843.0"/> <glyph class="macromolecule" id="akt1_akt2_s346_akt1_akt2_sa246"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CDC28 protein kinase regulatory subunit 1B HUGO:CKS1B HGNC:19083 ENTREZ:1163 UNIPROT:P61024 GENECARDS:CKS1B REACTOME:69869 KEGG:1163 ATLASONC:CKS1BID40092ch1q21 WIKI:CKS1B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15147722 PMID:11516665 References_end</body> </html> </notes> <label text="CKS1B"/> <bbox w="80.0" h="40.0" x="4769.25" y="4851.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s347_akt1_akt2_sa247"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> </notes> <label text="CUL1"/> <bbox w="80.0" h="40.0" x="4850.25" y="4851.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s348_akt1_akt2_sa248"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: S-phase kinase-associated protein 2 (p45) HUGO:SKP2 HGNC:10901 ENTREZ:6502 UNIPROT:Q13309 GENECARDS:SKP2 REACTOME:405589 KEGG:6502 ATLASONC:GC_SKP2 WIKI:SKP2 Q13309 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15147722 References_end</body> </html> </notes> <label text="SKP2"/> <bbox w="80.0" h="40.0" x="4850.25" y="4893.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s349_akt1_akt2_sa249"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 "S-phase kinase-associated protein 1A (p19A)", SKP1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 "S-phase kinase-associated protein 1A (p19A)", SKP1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 "S-phase kinase-associated protein 1A (p19A)", SKP1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> </notes> <label text="SKP1"/> <bbox w="80.0" h="40.0" x="4768.75" y="4893.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s353_akt1_akt2_csa42" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FOXO1:MIR27A Identifiers_end References_begin: s_akt2_re132:(MAP:survival) PMID:19574223 References_end</body> </html> </notes> <label text="FOXO1:MIR27A"/> <bbox w="100.0" h="120.0" x="5073.5" y="4335.0"/> <glyph class="nucleic acid feature" id="akt1_akt2_s356_akt1_akt2_sa253"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 27a HUGO:MIR27A HGNC:31613 ENTREZ:407018 GENECARDS:MIR27A KEGG:407018 ATLASONC:MIR27AID50398ch19p13 WIKI:MIR27A Identifiers_end References_begin: PMID:19574223 References_end</body> </html> </notes> <label text="MIR27A"/> <bbox w="90.0" h="25.0" x="5078.0" y="4352.0"/> <glyph class="unit of information" id="_f1a96a1e-37e4-4899-9fc7-2eede6099579"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="5108.0" y="4347.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_akt2_s359_akt1_akt2_sa256"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15668399 PMID:20673124 References_end</body> </html> </notes> <label text="FOXO1"/> <bbox w="90.0" h="25.0" x="5081.0" y="4384.0"/> <glyph class="unit of information" id="_3ef3a2c9-b845-49a1-ad74-0cbc6321260e"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5116.0" y="4379.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s354_akt1_akt2_csa43" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FOXO1:MIR96 Identifiers_end References_begin: s_akt2_re133:(MAP:survival) PMID:19574223 References_end</body> </html> </notes> <label text="FOXO1:MIR96"/> <bbox w="100.0" h="120.0" x="5183.0" y="4335.0"/> <glyph class="nucleic acid feature" id="akt1_akt2_s357_akt1_akt2_sa254"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 96 HUGO:MIR96 HGNC:31648 ENTREZ:407053 GENECARDS:MIR96 KEGG:407053 ATLASONC:GC_MIR96 WIKI:MIR96 Identifiers_end References_begin: PMID:19574223 References_end</body> </html> </notes> <label text="MIR96"/> <bbox w="90.0" h="25.0" x="5187.5" y="4355.0"/> <glyph class="unit of information" id="_f7159c87-eea3-478b-9130-5f3a9107b407"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="5217.5" y="4350.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_akt2_s360_akt1_akt2_sa257"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15668399 PMID:20673124 References_end</body> </html> </notes> <label text="FOXO1"/> <bbox w="90.0" h="25.0" x="5191.5" y="4386.0"/> <glyph class="unit of information" id="_512c7058-df1f-4796-8c96-057fd53e471a"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5226.5" y="4381.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s355_akt1_akt2_csa44" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FOXO1:MIR182 Identifiers_end References_begin: s_akt2_re134:(MAP:survival) PMID:19574223 References_end</body> </html> </notes> <label text="FOXO1:MIR182"/> <bbox w="100.0" h="120.0" x="5294.0" y="4335.0"/> <glyph class="nucleic acid feature" id="akt1_akt2_s358_akt1_akt2_sa255"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES Maps_Modules_end</body> </html> </notes> <label text="MIR182"/> <bbox w="90.0" h="25.0" x="5301.5" y="4357.0"/> <glyph class="unit of information" id="_0b055da4-a80f-4663-86c4-8e5555c217fc"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="5331.5" y="4352.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_akt2_s379_akt1_akt2_sa258"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15668399 PMID:20673124 References_end</body> </html> </notes> <label text="FOXO1"/> <bbox w="90.0" h="25.0" x="5299.0" y="4387.0"/> <glyph class="unit of information" id="_bcc9ff2c-10e0-4c61-bdc5-302f4df54c9e"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="5334.0" y="4382.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s364_akt1_akt2_csa45" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK4_6*:CyclinD*:p27KIP1* Identifiers_end References_begin: s_akt2_re136:(MAP:survival) PMID:11124803 PMID:12459251 References_end</body> </html> </notes> <label text="CDK4_6*:CyclinD*:p27KIP1*"/> <bbox w="103.0" h="157.0" x="6250.0" y="2930.5"/> <glyph class="macromolecule" id="akt1_akt2_s365_akt1_akt2_sa262"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 4 HUGO:CDK4 HGNC:1773 ENTREZ:1019 UNIPROT:P11802 GENECARDS:CDK4 REACTOME:68329 KEGG:1019 ATLASONC:CDK4ID238ch12q14 WIKI:CDK4 cyclin-dependent kinase 6 HUGO:CDK6 HGNC:1777 ENTREZ:1021 UNIPROT:Q00534 GENECARDS:CDK6 REACTOME:68335 KEGG:1021 ATLASONC:GC_CDK6 WIKI:CDK6 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 References_end</body> </html> </notes> <label text="CDK4_6*"/> <bbox w="80.0" h="40.0" x="6259.0" y="2935.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s367_akt1_akt2_sa263"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 References_end</body> </html> </notes> <label text="CyclinD*"/> <bbox w="80.0" h="40.0" x="6259.0" y="2976.5"/> <glyph class="state variable" id="_3576fe32-6942-4825-aa91-95a0cb672fa1"> <state value="P" variable="T286"/> <bbox w="35.0" h="10.0" x="6321.5" y="2971.7148"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s366_akt1_akt2_sa264"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 1B (p27 Kip1) HUGO:CDKN1B HGNC:1785 ENTREZ:1027 UNIPROT:P46527 GENECARDS:CDKN1B REACTOME:198633 KEGG:1027 ATLASONC:CDKN1BID116 WIKI:CDKN1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:CYCLINA MAP:cellcycle / MODULE:CYCLINE MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <label text="p27KIP1*"/> <bbox w="80.0" h="40.0" x="6259.0" y="3018.5"/> <glyph class="state variable" id="_6793ee8d-e319-4a50-bba8-76312e5aecf9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6294.0" y="3013.5"/> </glyph> <glyph class="state variable" id="_b12e7eb2-badf-4502-b325-98a356586036"> <state value="P" variable="S157"/> <bbox w="35.0" h="10.0" x="6321.5" y="3013.5"/> </glyph> <glyph class="state variable" id="_9aac1385-a92f-4293-bd2f-ac65f1953b10"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6294.0" y="3053.5"/> </glyph> <glyph class="state variable" id="_d5dc515c-ef93-429c-8347-8553998b9376"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="6274.9316" y="3013.5"/> </glyph> <glyph class="state variable" id="_9ec52805-88e7-4a95-b45a-4d787106ef73"> <state value="" variable="S10"/> <bbox w="25.0" h="10.0" x="6246.5" y="3015.902"/> </glyph> <glyph class="state variable" id="_93bf1693-3a82-4620-9e0b-6f2966a7da5c"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="6323.382" y="3053.5"/> </glyph> <glyph class="state variable" id="_45f6faae-d134-4bc0-a825-93774ae0fbad"> <state value="" variable="T157"/> <bbox w="30.0" h="10.0" x="6320.582" y="3013.5"/> </glyph> <glyph class="state variable" id="_6107c019-ab5f-496c-83ab-e8e1fa121173"> <state value="" variable="T198"/> <bbox w="30.0" h="10.0" x="6244.0" y="3053.2224"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s371_akt1_akt2_csa46" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CRM1*:CyclinD* Identifiers_end References_begin: s_akt2_re138:(MAP:survival) PMID:11124803 References_end</body> </html> </notes> <label text="CRM1*:CyclinD*"/> <bbox w="100.0" h="120.0" x="6494.0" y="3097.0"/> <glyph class="macromolecule" id="akt1_akt2_s372_akt1_akt2_sa268"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 References_end</body> </html> </notes> <label text="CyclinD*"/> <bbox w="80.0" h="40.0" x="6501.0" y="3109.0"/> <glyph class="state variable" id="_e0a9d323-2b71-4304-963c-76ceaddbf522"> <state value="P" variable="T286"/> <bbox w="35.0" h="10.0" x="6563.5" y="3104.2148"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s373_akt1_akt2_sa269"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> </notes> <label text="CRM1*"/> <bbox w="80.0" h="40.0" x="6499.5" y="3152.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s374_akt1_akt2_csa47" compartmentRef="akt1_akt2_c1_akt1_akt2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CRM1*:CyclinD* Identifiers_end References_begin: s_akt2_re139:(MAP:survival) PMID:11124803 References_end</body> </html> </notes> <label text="CRM1*:CyclinD*"/> <bbox w="100.0" h="120.0" x="6734.5" y="2874.0"/> <glyph class="macromolecule" id="akt1_akt2_s375_akt1_akt2_sa270"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 References_end</body> </html> </notes> <label text="CyclinD*"/> <bbox w="80.0" h="40.0" x="6741.5" y="2886.0"/> <glyph class="state variable" id="_3d60d93f-41bb-496a-9304-c1abcb3fe8ca"> <state value="P" variable="T286"/> <bbox w="35.0" h="10.0" x="6804.0" y="2881.2148"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s376_akt1_akt2_sa271"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> </notes> <label text="CRM1*"/> <bbox w="80.0" h="40.0" x="6740.0" y="2929.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s384_akt1_akt2_csa48" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PCNA:p21CIP1* Identifiers_end References_begin: s_akt2_re143:(MAP:survival) PMID:11756412 s_akt2_re149:(MAP:survival) PMID:19440234 References_end</body> </html> </notes> <label text="PCNA:p21CIP1*"/> <bbox w="100.0" h="120.0" x="6107.0" y="3991.0"/> <glyph class="macromolecule" id="akt1_akt2_s385_akt1_akt2_sa278"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: proliferating cell nuclear antigen HUGO:PCNA HGNC:8729 ENTREZ:5111 UNIPROT:P12004 GENECARDS:PCNA REACTOME:97870 ATLASONC:PCNAID41670ch20p12 WIKI:PCNA Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:BER MAP:dnarepair / MODULE:MMR MAP:dnarepair / MODULE:TLS MAP:cellcycle / MODULE:P21CIP MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11756412 References_end</body> </html> </notes> <label text="PCNA"/> <bbox w="80.0" h="40.0" x="6116.5" y="4000.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s386_akt1_akt2_sa279"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 GENECARDS:CDKN1A REACTOME:87048 KEGG:1026 ATLASONC:CDKN1AID139 WIKI:CDKN1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:P21CIP MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19440234 PMID:12851486 References_end</body> </html> </notes> <label text="p21CIP1*"/> <bbox w="80.0" h="40.0" x="6116.5" y="4044.0"/> <glyph class="state variable" id="_e60231b7-f3cf-48ff-b915-42f9adf94c4d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6111.5" y="4079.0"/> </glyph> <glyph class="state variable" id="_5e3e75e7-32a3-4b91-8e56-386fb54a8b6d"> <state value="" variable="T145"/> <bbox w="30.0" h="10.0" x="6101.9927" y="4039.0"/> </glyph> <glyph class="state variable" id="_07f6bcb5-6fb4-4ecd-b175-77773830b1ca"> <state value="" variable="T146"/> <bbox w="30.0" h="10.0" x="6141.5317" y="4039.0"/> </glyph> <glyph class="state variable" id="_85bac899-989a-48b3-afd0-9bf772b2653c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6191.5" y="4059.4016"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s390_akt1_akt2_csa49" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK4_6*:CyclinD*:p21CIP1* Identifiers_end</body> </html> </notes> <label text="CDK4_6*:CyclinD*:p21CIP1*"/> <bbox w="103.0" h="161.0" x="6486.0" y="3441.0"/> <glyph class="macromolecule" id="akt1_akt2_s391_akt1_akt2_sa283"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 GENECARDS:CDKN1A REACTOME:87048 KEGG:1026 ATLASONC:CDKN1AID139 WIKI:CDKN1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:P21CIP MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19440234 PMID:12851486 References_end</body> </html> </notes> <label text="p21CIP1*"/> <bbox w="80.0" h="40.0" x="6497.5" y="3539.0"/> <glyph class="state variable" id="_63573994-9fc4-48ed-b2e0-6c0e79790b8f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6492.5" y="3574.0"/> </glyph> <glyph class="state variable" id="_92d7e2a8-5cb5-4b57-8844-f014cd4ce3e4"> <state value="" variable="T145"/> <bbox w="30.0" h="10.0" x="6482.9927" y="3534.0"/> </glyph> <glyph class="state variable" id="_d3dc5f9e-cd63-43da-a5a9-e55c00d2b611"> <state value="" variable="T146"/> <bbox w="30.0" h="10.0" x="6522.5317" y="3534.0"/> </glyph> <glyph class="state variable" id="_1712ca5b-d960-48c5-9cdd-f60ba40eae14"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6572.5" y="3554.4016"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s392_akt1_akt2_sa284"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 4 HUGO:CDK4 HGNC:1773 ENTREZ:1019 UNIPROT:P11802 GENECARDS:CDK4 REACTOME:68329 KEGG:1019 ATLASONC:CDK4ID238ch12q14 WIKI:CDK4 cyclin-dependent kinase 6 HUGO:CDK6 HGNC:1777 ENTREZ:1021 UNIPROT:Q00534 GENECARDS:CDK6 REACTOME:68335 KEGG:1021 ATLASONC:GC_CDK6 WIKI:CDK6 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 References_end</body> </html> </notes> <label text="CDK4_6*"/> <bbox w="80.0" h="40.0" x="6495.5" y="3493.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s393_akt1_akt2_sa285"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 References_end</body> </html> </notes> <label text="CyclinD*"/> <bbox w="80.0" h="40.0" x="6496.0" y="3449.0"/> <glyph class="state variable" id="_30e91a73-4680-4de9-aff3-395620be4ae7"> <state value="P" variable="T286"/> <bbox w="35.0" h="10.0" x="6558.5" y="3444.2148"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s394_akt1_akt2_csa50" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDT2*:CUL4*:DDB1*:RBX1 Identifiers_end References_begin: s_akt2_re149:(MAP:survival) PMID:19440234 References_end</body> </html> </notes> <label text="CDT2*:CUL4*:DDB1*:RBX1"/> <bbox w="183.0" h="126.0" x="6401.0" y="3648.0"/> <glyph class="macromolecule" id="akt1_akt2_s395_akt1_akt2_sa286"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> </notes> <label text="RBX1"/> <bbox w="80.0" h="40.0" x="6410.5" y="3709.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s396_akt1_akt2_sa287"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cullin 4A HUGO:CUL4A HGNC:2554 ENTREZ:8451 UNIPROT:Q13619 GENECARDS:CUL4A ATLASONC:GC_CUL4A WIKI:CUL4A cullin 4B HUGO:CUL4B HGNC:2555 ENTREZ:8450 UNIPROT:Q13620 GENECARDS:CUL4B KEGG:8450 ATLASONC:GC_CUL4B WIKI:CUL4B Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:NER MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19440234 PMID:18381890 References_end</body> </html> </notes> <label text="CUL4*"/> <bbox w="80.0" h="40.0" x="6494.0" y="3708.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s397_akt1_akt2_sa288"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DDB1 and CUL4 associated factor 4 HUGO:DCAF4 HGNC:20229 ENTREZ:26094 UNIPROT:Q8WV16 GENECARDS:DCAF4 KEGG:26094 WIKI:DCAF4 DDB1 and CUL4 associated factor 5 HUGO:DCAF5 HGNC:20224 ENTREZ:8816 UNIPROT:Q96JK2 GENECARDS:DCAF5 KEGG:8816 ATLASONC:GC_DCAF5 WIKI:DCAF5 DDB1 and CUL4 associated factor 6 HUGO:DCAF6 HGNC:30002 ENTREZ:55827 UNIPROT:Q58WW2 GENECARDS:DCAF6 KEGG:55827 ATLASONC:GC_DCAF6 WIKI:DCAF6 DDB1 and CUL4 associated factor 7 HUGO:DCAF7 HGNC:30915 ENTREZ:10238 UNIPROT:P61962 GENECARDS:DCAF7 KEGG:10238 ATLASONC:GC_DCAF7 WIKI:DCAF7 DDB1 and CUL4 associated factor 8 HUGO:DCAF8 HGNC:24891 ENTREZ:50717 UNIPROT:Q5TAQ9 GENECARDS:DCAF8 KEGG:50717 WIKI:DCAF8 DDB1 and CUL4 associated factor 10 HUGO:DCAF10 HGNC:23686 ENTREZ:79269 UNIPROT:Q5QP82 GENECARDS:DCAF10 KEGG:79269 WIKI:DCAF10 DDB1 and CUL4 associated factor 11 HUGO:DCAF11 HGNC:20258 ENTREZ:80344 UNIPROT:Q8TEB1 GENECARDS:DCAF11 KEGG:80344 WIKI:DCAF11 DDB1 and CUL4 associated factor 12 HUGO:DCAF12 HGNC:19911 ENTREZ:25853 UNIPROT:Q5T6F0 GENECARDS:DCAF12 KEGG:25853 ATLASONC:GC_DCAF12 WIKI:DCAF12 DDB1 and CUL4 associated factor 13 HUGO:DCAF13 HGNC:24535 ENTREZ:25879 UNIPROT:Q9NV06 GENECARDS:DCAF13 KEGG:25879 ATLASONC:GC_DCAF13 WIKI:DCAF13 DDB1 and CUL4 associated factor 15 HUGO:DCAF15 HGNC:25095 ENTREZ:90379 UNIPROT:Q66K64 GENECARDS:DCAF15 KEGG:90379 WIKI:DCAF15 DDB1 and CUL4 associated factor 16 HUGO:DCAF16 HGNC:25987 ENTREZ:54876 UNIPROT:Q9NXF7 GENECARDS:DCAF16 KEGG:54876 WIKI:DCAF16 DDB1 and CUL4 associated factor 17 HUGO:DCAF17 HGNC:25784 ENTREZ:80067 UNIPROT:Q5H9S7 GENECARDS:DCAF17 KEGG:80067 WIKI:DCAF17 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18381890 PMID:19440234 References_end</body> </html> </notes> <label text="DDB1*"/> <bbox w="80.0" h="40.0" x="6410.0" y="3662.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s398_akt1_akt2_sa289"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CDT2 HUGO:DTL HGNC:30288 ENTREZ:51514 UNIPROT:Q9NZJ0 GENECARDS:DTL KEGG:10673 ATLASONC:GC_DTL WIKI:DTL Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11278750 References_end</body> </html> </notes> <label text="CDT2*"/> <bbox w="80.0" h="40.0" x="6493.0" y="3662.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s399_akt1_akt2_csa51" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PCNA:p21CIP1* Identifiers_end References_begin: s_akt2_re149:(MAP:survival) PMID:19440234 References_end</body> </html> </notes> <label text="PCNA:p21CIP1*"/> <bbox w="100.0" h="120.0" x="5968.5" y="3991.0"/> <glyph class="macromolecule" id="akt1_akt2_s400_akt1_akt2_sa290"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: proliferating cell nuclear antigen HUGO:PCNA HGNC:8729 ENTREZ:5111 UNIPROT:P12004 GENECARDS:PCNA REACTOME:97870 ATLASONC:PCNAID41670ch20p12 WIKI:PCNA Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:BER MAP:dnarepair / MODULE:MMR MAP:dnarepair / MODULE:TLS MAP:cellcycle / MODULE:P21CIP MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11756412 References_end</body> </html> </notes> <label text="PCNA"/> <bbox w="80.0" h="40.0" x="5978.0" y="4000.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s401_akt1_akt2_sa291"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: cyclin-dependent kinase inhibitor 1A (P21 Cip1) CDKN1 HUGO:CDKN1A HGNC:1784 ENTREZ:1026 UNIPROT:P38936 GENECARDS:CDKN1A REACTOME:87048 KEGG:1026 ATLASONC:CDKN1AID139 WIKI:CDKN1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:cellcycle / MODULE:P21CIP MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19440234 PMID:12851486 References_end</body> </html> </notes> <label text="p21CIP1*"/> <bbox w="80.0" h="40.0" x="5978.0" y="4044.0"/> <glyph class="state variable" id="_1c4b96c3-62ef-4d82-90a1-8f491be179a9"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="5968.0" y="4079.0"/> </glyph> <glyph class="state variable" id="_48ba3f67-3bef-4fff-a974-e9ab75aa320a"> <state value="" variable="T145"/> <bbox w="30.0" h="10.0" x="5963.4927" y="4039.0"/> </glyph> <glyph class="state variable" id="_7cf8a300-4bfc-4ce2-a9a5-5e78b6ba92fc"> <state value="" variable="T146"/> <bbox w="30.0" h="10.0" x="6003.0317" y="4039.0"/> </glyph> <glyph class="state variable" id="_be921860-5f12-4a2a-9663-0baf2b4169db"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="6053.0" y="4059.4016"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s408_akt1_akt2_csa52" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CBP*:promoter_region Identifiers_end References_begin: s_akt2_re153:(MAP:survival) PMID:9829964 s_akt2_re151:(MAP:survival) PMID:10753867 s_akt2_re154:(MAP:survival) PMID:10454566 References_end</body> </html> </notes> <label text="CREB_CRP_promoter"/> <bbox w="103.0" h="147.0" x="6249.0" y="4421.0"/> <glyph class="macromolecule" id="akt1_akt2_s410_akt1_akt2_sa299"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end</body> </html> Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end</body> </html> </notes> <label text="CBP*"/> <bbox w="80.0" h="40.0" x="6255.5" y="4430.0"/> <glyph class="state variable" id="_e2954c87-b2c7-408b-9fb9-4e9b2004ffcb"> <state value="" variable="S92"/> <bbox w="25.0" h="10.0" x="6243.4927" y="4425.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s410_akt1_akt2_sa300"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end</body> </html> Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end</body> </html> </notes> <label text="CBP*"/> <bbox w="80.0" h="40.0" x="6255.5" y="4471.0"/> <glyph class="state variable" id="_74e1fb8f-777b-4a64-9539-107e31993685"> <state value="" variable="S92"/> <bbox w="25.0" h="10.0" x="6243.4927" y="4466.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_akt2_s411_akt1_akt2_sa301"> <label text="promoter_region"/> <bbox w="70.0" h="25.0" x="6259.5" y="4515.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s416_akt1_akt2_csa53" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MIR214:PTEN Identifiers_end References_begin: s_akt2_re156:(MAP:survival) PMID:18199536 References_end</body> </html> </notes> <label text="MIR214:PTEN"/> <bbox w="100.0" h="120.0" x="4949.0" y="4335.0"/> <glyph class="nucleic acid feature" id="akt1_akt2_s421_akt1_akt2_sa306"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homo Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homo Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end</body> </html> </notes> <label text="PTEN"/> <bbox w="90.0" h="25.0" x="4954.5" y="4386.0"/> <glyph class="unit of information" id="_b86d7228-cb1d-48c9-87c2-d614dd2ce200"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="4989.5" y="4381.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_akt2_s426_akt1_akt2_sa307"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 214 HUGO:MIR214 HGNC:31591 ENTREZ:406996 GENECARDS:MIR214 KEGG:406996 ATLASONC:GC_MIR214 WIKI:MIR214 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES Maps_Modules_end References_begin: PMID:20083225 References_end</body> </html> </notes> <label text="MIR214"/> <bbox w="90.0" h="25.0" x="4955.5" y="4352.0"/> <glyph class="unit of information" id="_3f5ffd84-e11d-4c99-83ac-00d8c4573d90"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="4985.5" y="4347.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s432_akt1_akt2_csa55" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FOXO1:RUNX2 Identifiers_end References_begin: s_akt2_re158:(MAP:survival) PMID:21505104 References_end</body> </html> </notes> <label text="FOXO1:RUNX2"/> <bbox w="100.0" h="120.0" x="6294.0" y="3932.0"/> <glyph class="macromolecule" id="akt1_akt2_s433_akt1_akt2_sa313"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Runt-related transcription factor 2 HUGO:RUNX2 HGNC:10472 ENTREZ:860 UNIPROT:Q13950 GENECARDS:RUNX2 REACTOME:63858 KEGG:860 ATLASONC:RUNX2ID42183ch6p21 WIKI:RUNX2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20946121 PMID:20580290 References_end</body> </html> </notes> <label text="RUNX2"/> <bbox w="80.0" h="40.0" x="6303.625" y="3942.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s434_akt1_akt2_sa314"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end</body> </html> </notes> <label text="FOXO1"/> <bbox w="80.0" h="40.0" x="6303.875" y="3987.0"/> <glyph class="state variable" id="_6bd43936-ab04-4610-b25c-b6f6f0dcd352"> <state value="" variable="S329"/> <bbox w="30.0" h="10.0" x="6288.875" y="4021.7224"/> </glyph> <glyph class="state variable" id="_945fb576-049f-438b-8018-6710d44928fd"> <state value="" variable="S319"/> <bbox w="30.0" h="10.0" x="6368.875" y="3982.0"/> </glyph> <glyph class="state variable" id="_3927ffd2-703c-4020-b82b-4fecb4461acb"> <state value="" variable="S325"/> <bbox w="30.0" h="10.0" x="6328.7793" y="4022.0"/> </glyph> <glyph class="state variable" id="_49d31f7b-e635-4cad-b168-88c291ffe2bc"> <state value="" variable="S322"/> <bbox w="30.0" h="10.0" x="6368.257" y="4022.0"/> </glyph> <glyph class="state variable" id="_95c19686-55d7-42de-abf5-5ee444e4e28e"> <state value="" variable="S256"/> <bbox w="30.0" h="10.0" x="6328.9067" y="3982.0"/> </glyph> <glyph class="state variable" id="_4e6f8f57-fe1f-467d-a5ad-1c3ced9031cc"> <state value="" variable="T24"/> <bbox w="25.0" h="10.0" x="6291.8677" y="3982.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s435_akt1_akt2_csa1" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FOXO3:promoter_region Identifiers_end References_begin: s_akt2_re1:(MAP:survival) PMID:10783894 PMID:20673124 PMID:11094066 PMID:11994454 s_akt2_re2:(MAP:survival) PMID:11154281 s_akt2_re79(MAP:survival): PMID:17646672 PMID20673124 s_akt2_re80:(MAP:survival) PMID15084260 s_akt2_re86:(MAP:survival) PMID:15509806 PMID:20673124 s_akt2_re93:(MAP:survival) PMID19244250 s_akt2_re103(MAP:survival): PMID:18644865 References_end</body> </html> </notes> <label text="(FOXO_gene)"/> <bbox w="100.0" h="110.0" x="5017.0" y="2969.25"/> <glyph class="macromolecule" id="akt1_akt2_s9_akt1_akt2_sa8"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 GENECARDS:FOXO3 REACTOME:199273 KEGG:2309 ATLASONC:AF6q21ID125 WIKI:FOXO3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16288288 PMID:17646672 References_end</body> </html> </notes> <label text="FOXO3"/> <bbox w="80.0" h="40.0" x="5024.5" y="2980.75"/> <glyph class="state variable" id="_1054c37f-e9ec-46a4-aa0f-b5db6e0cd897"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5059.5" y="2975.75"/> </glyph> <glyph class="state variable" id="_58927d30-3da1-42b4-aab8-c259b17aff3a"> <state value="" variable="S644"/> <bbox w="30.0" h="10.0" x="5009.5" y="3015.4724"/> </glyph> <glyph class="state variable" id="_2189d4bb-78a5-4ec6-8656-e8ccffdf38e0"> <state value="" variable="T32"/> <bbox w="25.0" h="10.0" x="5012.0" y="2976.6802"/> </glyph> <glyph class="state variable" id="_0aeeb24e-d501-4ff3-9672-50176f866e45"> <state value="" variable="S253"/> <bbox w="30.0" h="10.0" x="5089.5" y="3014.8806"/> </glyph> <glyph class="state variable" id="_fe45a9cd-db3c-47d9-85a2-de05df26a26d"> <state value="" variable="S315"/> <bbox w="30.0" h="10.0" x="5086.082" y="2975.75"/> </glyph> <glyph class="state variable" id="_82222f9b-f252-4112-b348-d22933e28ce5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5019.5" y="2995.75"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_akt2_s10_akt1_akt2_sa9"> <label text="promoter_region"/> <bbox w="70.0" h="25.0" x="5031.0" y="3029.75"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s436_akt1_akt2_csa2" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FOXO3:promoter_region Identifiers_end References_begin: s_akt2_re2:(MAP:survival) PMID:11154281 References_end</body> </html> </notes> <label text="(FOXO_gene)"/> <bbox w="100.0" h="110.0" x="4875.75" y="2969.25"/> <glyph class="macromolecule" id="akt1_akt2_s16_akt1_akt2_sa10"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 GENECARDS:FOXO3 REACTOME:199273 KEGG:2309 ATLASONC:AF6q21ID125 WIKI:FOXO3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16288288 PMID:17646672 References_end</body> </html> </notes> <label text="FOXO3"/> <bbox w="80.0" h="40.0" x="4883.25" y="2980.75"/> <glyph class="state variable" id="_6f8b2d31-ff6c-41ed-87b1-89067bbfe481"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4918.25" y="2975.75"/> </glyph> <glyph class="state variable" id="_db7fcd41-387d-46d2-99ef-f6d7b2544ecc"> <state value="" variable="S644"/> <bbox w="30.0" h="10.0" x="4868.25" y="3015.4724"/> </glyph> <glyph class="state variable" id="_c36b8129-f4c4-4329-ad61-d5d9664e07d1"> <state value="" variable="T32"/> <bbox w="25.0" h="10.0" x="4870.75" y="2976.6802"/> </glyph> <glyph class="state variable" id="_2f340968-0128-4d7f-9117-74ca1feddf15"> <state value="" variable="S253"/> <bbox w="30.0" h="10.0" x="4948.25" y="3014.8806"/> </glyph> <glyph class="state variable" id="_894a153d-041f-443d-842e-e4a89add223f"> <state value="" variable="S315"/> <bbox w="30.0" h="10.0" x="4944.832" y="2975.75"/> </glyph> <glyph class="state variable" id="_aa07f305-aa7c-462f-919f-6896b1983f48"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4878.25" y="2995.75"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_akt2_s15_akt1_akt2_sa11"> <label text="promoter_region"/> <bbox w="70.0" h="25.0" x="4889.75" y="3029.75"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s437_akt1_akt2_csa3" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FOXO3:promoter_region Identifiers_end</body> </html> </notes> <label text="(FOXO_gene)"/> <bbox w="100.0" h="110.0" x="4734.5" y="2969.25"/> <glyph class="macromolecule" id="akt1_akt2_s20_akt1_akt2_sa16"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: forkhead box O3 FKHRL1 FOXO3A HUGO:FOXO3 HGNC:3821 ENTREZ:2309 UNIPROT:O43524 GENECARDS:FOXO3 REACTOME:199273 KEGG:2309 ATLASONC:AF6q21ID125 WIKI:FOXO3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16288288 PMID:17646672 References_end</body> </html> </notes> <label text="FOXO3"/> <bbox w="80.0" h="40.0" x="4742.0" y="2980.75"/> <glyph class="state variable" id="_8ecb89c1-7cee-4b4e-b194-6d55af42feb5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4777.0" y="2975.75"/> </glyph> <glyph class="state variable" id="_80200cc5-85e6-4fdd-9484-3e3213721e39"> <state value="" variable="S644"/> <bbox w="30.0" h="10.0" x="4727.0" y="3015.4724"/> </glyph> <glyph class="state variable" id="_9485a971-15c1-43d3-ac1f-1327c0e27242"> <state value="" variable="T32"/> <bbox w="25.0" h="10.0" x="4729.5" y="2976.6802"/> </glyph> <glyph class="state variable" id="_f93fd0ee-300a-44c6-b518-f827fdf4cb4c"> <state value="" variable="S253"/> <bbox w="30.0" h="10.0" x="4807.0" y="3014.8806"/> </glyph> <glyph class="state variable" id="_9a0f1426-8dc7-420e-aabd-574f136f0f5a"> <state value="" variable="S315"/> <bbox w="30.0" h="10.0" x="4803.582" y="2975.75"/> </glyph> <glyph class="state variable" id="_2ca3066e-f4bf-4cb8-8b94-dabc9ac03e52"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="4737.0" y="2995.75"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_akt2_s18_akt1_akt2_sa15"> <label text="promoter_region"/> <bbox w="70.0" h="25.0" x="4748.5" y="3029.75"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s438_akt1_akt2_csa8" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PP2A_A*:PP2A_B*:PP2A_C* Identifiers_end References_begin: s_akt2_re27(MAP:survival): PMID:16680151 PMID:20452955 PMID:19216069 References_end</body> </html> </notes> <label text="(PP2A)"/> <clone/> <bbox w="97.0" h="149.0" x="5427.0" y="4329.0"/> <glyph class="macromolecule" id="akt1_akt2_s439_akt1_akt2_sa54"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: protein phosphatase 2 regulatory subunit A alpha HUGO:PPP2R1A HGNC:9302 ENTREZ:5518 UNIPROT:P30153 GENECARDS:PPP2R1A REACTOME:49125 KEGG:5518 ATLASONC:GC_PPP2R1A WIKI:PPP2R1A protein phosphatase 2 regulatory subunit B beta HUGO:PPP2R1B HGNC:9303 ENTREZ:5519 UNIPROT:P30154 GENECARDS:PPP2R1B REACTOME:49127 KEGG:5519 ATLASONC:GC_PPP2R1B WIKI:PPP2R1B PP2A-Aalpha, PR65A, "protein phosphatase 2, 65kDa regulatory subunit A", "protein phosphatase 2A, regulatory subunit A, alpha isoform" protein phosphatase 2, regulatory subunit A, beta Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18559511 PMID:10026142 Structural sub-unit References_end Identifiers_begin: protein phosphatase 2 regulatory subunit A alpha HUGO:PPP2R1A HGNC:9302 ENTREZ:5518 UNIPROT:P30153 GENECARDS:PPP2R1A REACTOME:49125 KEGG:5518 ATLASONC:GC_PPP2R1A WIKI:PPP2R1A protein phosphatase 2 regulatory subunit B beta HUGO:PPP2R1B HGNC:9303 ENTREZ:5519 UNIPROT:P30154 GENECARDS:PPP2R1B REACTOME:49127 KEGG:5519 ATLASONC:GC_PPP2R1B WIKI:PPP2R1B PP2A-Aalpha, PR65A, "protein phosphatase 2, 65kDa regulatory subunit A", "protein phosphatase 2A, regulatory subunit A, alpha isoform" protein phosphatase 2, regulatory subunit A, beta Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18559511 PMID:10026142 Structural sub-unit References_end</body> </html> Identifiers_begin: protein phosphatase 2 regulatory subunit A alpha HUGO:PPP2R1A HGNC:9302 ENTREZ:5518 UNIPROT:P30153 GENECARDS:PPP2R1A REACTOME:49125 KEGG:5518 ATLASONC:GC_PPP2R1A WIKI:PPP2R1A protein phosphatase 2 regulatory subunit B beta HUGO:PPP2R1B HGNC:9303 ENTREZ:5519 UNIPROT:P30154 GENECARDS:PPP2R1B REACTOME:49127 KEGG:5519 ATLASONC:GC_PPP2R1B WIKI:PPP2R1B PP2A-Aalpha, PR65A, "protein phosphatase 2, 65kDa regulatory subunit A", "protein phosphatase 2A, regulatory subunit A, alpha isoform" protein phosphatase 2, regulatory subunit A, beta Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18559511 PMID:10026142 Structural sub-unit References_end</body> </html> </notes> <label text="PP2A_A*"/> <clone/> <bbox w="80.0" h="40.0" x="5436.0" y="4335.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s440_akt1_akt2_sa55"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 References_end Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> </notes> <label text="PP2A_C*"/> <clone/> <bbox w="80.0" h="40.0" x="5436.0" y="4374.0"/> <glyph class="state variable" id="_3e8e6163-c908-4498-b0c9-738c3d65a62d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5431.0" y="4389.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s441_akt1_akt2_sa56"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: protein phosphatase 2 regulatory subunit B alpha HUGO:PPP2R2A HGNC:9304 ENTREZ:5520 UNIPROT:P63151 GENECARDS:PPP2R2A REACTOME:49129 KEGG:5520 ATLASONC:GC_PPP2R2A WIKI:PPP2R2A P63151 protein phosphatase 2 regulatory subunit B beta HUGO:PPP2R2B HGNC:9305 ENTREZ:5521 UNIPROT:Q00005 GENECARDS:PPP2R2B KEGG:5521 ATLASONC:GC_PPP2R2B WIKI:PPP2R2B Q00005 protein phosphatase 2 regulatory subunit B gamma HUGO:PPP2R2C HGNC:9306 ENTREZ:5522 UNIPROT:Q9Y2T4 GENECARDS:PPP2R2C KEGG:5522 ATLASONC:GC_PPP2R2C WIKI:PPP2R2C Q9Y2T4 protein phosphatase 2 regulatory subunit B delta HUGO:PPP2R2D HGNC:23732 ENTREZ:55844 UNIPROT:Q66LE6 GENECARDS:PPP2R2D REACTOME:217408 KEGG:55844 ATLASONC:GC_PPP2R2D WIKI:PPP2R2D Q66LE6 PP2A 55 kDa regulatory subunit B beta isoform PP2A 55 kDa regulatory subunit B gamma isoform PP2A 55 kDa regulatory subunit B delta isoform PP2A 72/130 kDa regulatory subunit B HUGO:PPP2R3A HGNC:9307 ENTREZ:5523 UNIPROT:Q06190 GENECARDS:PPP2R3A KEGG:5523 ATLASONC:GC_PPP2R3A WIKI:PPP2R3A PP2A 48 kDa regulatory subunit B HUGO:PPP2R3B HGNC:13417 ENTREZ:28227 UNIPROT:Q9Y5P8 GENECARDS:PPP2R3B REACTOME:49140 KEGG:28227 ATLASONC:GC_PPP2R3B WIKI:PPP2R3B PP2A regulatory subunit B'' subunit gamma HUGO:PPP2R3C HGNC:17485 ENTREZ:55012 UNIPROT:Q969Q6 GENECARDS:PPP2R3C KEGG:55012 WIKI:PPP2R3C PP2A regulatory subunit B' HUGO:PPP2R4 HGNC:9308 ENTREZ:5524 UNIPROT:Q15257 GENECARDS:PPP2R4 KEGG:5524 ATLASONC:PPP2R4ID41817ch9q34 WIKI:PPP2R4 PP2A 56 kDa regulatory subunit alpha isoform HUGO:PPP2R5A HGNC:9309 ENTREZ:5525 UNIPROT:Q15172 GENECARDS:PPP2R5A REACTOME:49115 KEGG:5525 ATLASONC:GC_PPP2R5A WIKI:PPP2R5A PP2A 56 kDa regulatory subunit beta isoform HUGO:PPP2R5B HGNC:9310 ENTREZ:5526 UNIPROT:Q15173 GENECARDS:PPP2R5B REACTOME:405832 KEGG:5526 ATLASONC:GC_PPP2R5B WIKI:PPP2R5B PP2A 56 kDa regulatory subunit gamma isoform HUGO:PPP2R5C HGNC:9311 ENTREZ:5527 UNIPROT:Q13362 GENECARDS:PPP2R5C REACTOME:405599 KEGG:5527 ATLASONC:GC_PPP2R5C WIKI:PPP2R5C PP2A 56 kDa regulatory subunit delta isoform HUGO:PPP2R5D HGNC:9312 ENTREZ:5528 UNIPROT:Q14738 GENECARDS:PPP2R5D REACTOME:405743 KEGG:5528 ATLASONC:GC_PPP2R5D WIKI:PPP2R5D PP2A 56 kDa regulatory subunit epsilon isoform HUGO:PPP2R5E HGNC:9313 ENTREZ:5529 UNIPROT:Q16537 GENECARDS:PPP2R5E REACTOME:49121 ATLASONC:GC_PPP2R5E WIKI:PPP2R5E Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 References_end Identifiers_begin: protein phosphatase 2 regulatory subunit B alpha HUGO:PPP2R2A HGNC:9304 ENTREZ:5520 UNIPROT:P63151 GENECARDS:PPP2R2A REACTOME:49129 KEGG:5520 ATLASONC:GC_PPP2R2A WIKI:PPP2R2A P63151 protein phosphatase 2 regulatory subunit B beta HUGO:PPP2R2B HGNC:9305 ENTREZ:5521 UNIPROT:Q00005 GENECARDS:PPP2R2B KEGG:5521 ATLASONC:GC_PPP2R2B WIKI:PPP2R2B Q00005 protein phosphatase 2 regulatory subunit B gamma HUGO:PPP2R2C HGNC:9306 ENTREZ:5522 UNIPROT:Q9Y2T4 GENECARDS:PPP2R2C KEGG:5522 ATLASONC:GC_PPP2R2C WIKI:PPP2R2C Q9Y2T4 protein phosphatase 2 regulatory subunit B delta HUGO:PPP2R2D HGNC:23732 ENTREZ:55844 UNIPROT:Q66LE6 GENECARDS:PPP2R2D REACTOME:217408 KEGG:55844 ATLASONC:GC_PPP2R2D WIKI:PPP2R2D Q66LE6 PP2A 55 kDa regulatory subunit B beta isoform PP2A 55 kDa regulatory subunit B gamma isoform PP2A 55 kDa regulatory subunit B delta isoform PP2A 72/130 kDa regulatory subunit B HUGO:PPP2R3A HGNC:9307 ENTREZ:5523 UNIPROT:Q06190 GENECARDS:PPP2R3A KEGG:5523 ATLASONC:GC_PPP2R3A WIKI:PPP2R3A PP2A 48 kDa regulatory subunit B HUGO:PPP2R3B HGNC:13417 ENTREZ:28227 UNIPROT:Q9Y5P8 GENECARDS:PPP2R3B REACTOME:49140 KEGG:28227 ATLASONC:GC_PPP2R3B WIKI:PPP2R3B PP2A regulatory subunit B'' subunit gamma HUGO:PPP2R3C HGNC:17485 ENTREZ:55012 UNIPROT:Q969Q6 GENECARDS:PPP2R3C KEGG:55012 WIKI:PPP2R3C PP2A regulatory subunit B' HUGO:PPP2R4 HGNC:9308 ENTREZ:5524 UNIPROT:Q15257 GENECARDS:PPP2R4 KEGG:5524 ATLASONC:PPP2R4ID41817ch9q34 WIKI:PPP2R4 PP2A 56 kDa regulatory subunit alpha isoform HUGO:PPP2R5A HGNC:9309 ENTREZ:5525 UNIPROT:Q15172 GENECARDS:PPP2R5A REACTOME:49115 KEGG:5525 ATLASONC:GC_PPP2R5A WIKI:PPP2R5A PP2A 56 kDa regulatory subunit beta isoform HUGO:PPP2R5B HGNC:9310 ENTREZ:5526 UNIPROT:Q15173 GENECARDS:PPP2R5B REACTOME:405832 KEGG:5526 ATLASONC:GC_PPP2R5B WIKI:PPP2R5B PP2A 56 kDa regulatory subunit gamma isoform HUGO:PPP2R5C HGNC:9311 ENTREZ:5527 UNIPROT:Q13362 GENECARDS:PPP2R5C REACTOME:405599 KEGG:5527 ATLASONC:GC_PPP2R5C WIKI:PPP2R5C PP2A 56 kDa regulatory subunit delta isoform HUGO:PPP2R5D HGNC:9312 ENTREZ:5528 UNIPROT:Q14738 GENECARDS:PPP2R5D REACTOME:405743 KEGG:5528 ATLASONC:GC_PPP2R5D WIKI:PPP2R5D PP2A 56 kDa regulatory subunit epsilon isoform HUGO:PPP2R5E HGNC:9313 ENTREZ:5529 UNIPROT:Q16537 GENECARDS:PPP2R5E REACTOME:49121 ATLASONC:GC_PPP2R5E WIKI:PPP2R5E Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 References_end</body> </html> </notes> <label text="PP2A_B*"/> <clone/> <bbox w="80.0" h="40.0" x="5437.0" y="4413.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s438_akt1_akt2_csa9" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PP2A_A*:PP2A_B*:PP2A_C* Identifiers_end References_begin: s_akt2_re27(MAP:survival): PMID:16680151 PMID:20452955 PMID:19216069 References_end</body> </html> </notes> <label text="(PP2A)"/> <clone/> <bbox w="97.0" h="149.0" x="5427.5" y="4128.5"/> <glyph class="macromolecule" id="akt1_akt2_s439_akt1_akt2_sa57"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: protein phosphatase 2 regulatory subunit A alpha HUGO:PPP2R1A HGNC:9302 ENTREZ:5518 UNIPROT:P30153 GENECARDS:PPP2R1A REACTOME:49125 KEGG:5518 ATLASONC:GC_PPP2R1A WIKI:PPP2R1A protein phosphatase 2 regulatory subunit B beta HUGO:PPP2R1B HGNC:9303 ENTREZ:5519 UNIPROT:P30154 GENECARDS:PPP2R1B REACTOME:49127 KEGG:5519 ATLASONC:GC_PPP2R1B WIKI:PPP2R1B PP2A-Aalpha, PR65A, "protein phosphatase 2, 65kDa regulatory subunit A", "protein phosphatase 2A, regulatory subunit A, alpha isoform" protein phosphatase 2, regulatory subunit A, beta Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18559511 PMID:10026142 Structural sub-unit References_end Identifiers_begin: protein phosphatase 2 regulatory subunit A alpha HUGO:PPP2R1A HGNC:9302 ENTREZ:5518 UNIPROT:P30153 GENECARDS:PPP2R1A REACTOME:49125 KEGG:5518 ATLASONC:GC_PPP2R1A WIKI:PPP2R1A protein phosphatase 2 regulatory subunit B beta HUGO:PPP2R1B HGNC:9303 ENTREZ:5519 UNIPROT:P30154 GENECARDS:PPP2R1B REACTOME:49127 KEGG:5519 ATLASONC:GC_PPP2R1B WIKI:PPP2R1B PP2A-Aalpha, PR65A, "protein phosphatase 2, 65kDa regulatory subunit A", "protein phosphatase 2A, regulatory subunit A, alpha isoform" protein phosphatase 2, regulatory subunit A, beta Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18559511 PMID:10026142 Structural sub-unit References_end</body> </html> Identifiers_begin: protein phosphatase 2 regulatory subunit A alpha HUGO:PPP2R1A HGNC:9302 ENTREZ:5518 UNIPROT:P30153 GENECARDS:PPP2R1A REACTOME:49125 KEGG:5518 ATLASONC:GC_PPP2R1A WIKI:PPP2R1A protein phosphatase 2 regulatory subunit B beta HUGO:PPP2R1B HGNC:9303 ENTREZ:5519 UNIPROT:P30154 GENECARDS:PPP2R1B REACTOME:49127 KEGG:5519 ATLASONC:GC_PPP2R1B WIKI:PPP2R1B PP2A-Aalpha, PR65A, "protein phosphatase 2, 65kDa regulatory subunit A", "protein phosphatase 2A, regulatory subunit A, alpha isoform" protein phosphatase 2, regulatory subunit A, beta Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18559511 PMID:10026142 Structural sub-unit References_end</body> </html> </notes> <label text="PP2A_A*"/> <clone/> <bbox w="80.0" h="40.0" x="5436.5" y="4134.5"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s440_akt1_akt2_sa58"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 References_end Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> </notes> <label text="PP2A_C*"/> <clone/> <bbox w="80.0" h="40.0" x="5436.5" y="4173.5"/> <glyph class="state variable" id="_157e99cd-dd4d-4d31-8df9-9d26966aa238"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5431.5" y="4188.5"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s441_akt1_akt2_sa59"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: protein phosphatase 2 regulatory subunit B alpha HUGO:PPP2R2A HGNC:9304 ENTREZ:5520 UNIPROT:P63151 GENECARDS:PPP2R2A REACTOME:49129 KEGG:5520 ATLASONC:GC_PPP2R2A WIKI:PPP2R2A P63151 protein phosphatase 2 regulatory subunit B beta HUGO:PPP2R2B HGNC:9305 ENTREZ:5521 UNIPROT:Q00005 GENECARDS:PPP2R2B KEGG:5521 ATLASONC:GC_PPP2R2B WIKI:PPP2R2B Q00005 protein phosphatase 2 regulatory subunit B gamma HUGO:PPP2R2C HGNC:9306 ENTREZ:5522 UNIPROT:Q9Y2T4 GENECARDS:PPP2R2C KEGG:5522 ATLASONC:GC_PPP2R2C WIKI:PPP2R2C Q9Y2T4 protein phosphatase 2 regulatory subunit B delta HUGO:PPP2R2D HGNC:23732 ENTREZ:55844 UNIPROT:Q66LE6 GENECARDS:PPP2R2D REACTOME:217408 KEGG:55844 ATLASONC:GC_PPP2R2D WIKI:PPP2R2D Q66LE6 PP2A 55 kDa regulatory subunit B beta isoform PP2A 55 kDa regulatory subunit B gamma isoform PP2A 55 kDa regulatory subunit B delta isoform PP2A 72/130 kDa regulatory subunit B HUGO:PPP2R3A HGNC:9307 ENTREZ:5523 UNIPROT:Q06190 GENECARDS:PPP2R3A KEGG:5523 ATLASONC:GC_PPP2R3A WIKI:PPP2R3A PP2A 48 kDa regulatory subunit B HUGO:PPP2R3B HGNC:13417 ENTREZ:28227 UNIPROT:Q9Y5P8 GENECARDS:PPP2R3B REACTOME:49140 KEGG:28227 ATLASONC:GC_PPP2R3B WIKI:PPP2R3B PP2A regulatory subunit B'' subunit gamma HUGO:PPP2R3C HGNC:17485 ENTREZ:55012 UNIPROT:Q969Q6 GENECARDS:PPP2R3C KEGG:55012 WIKI:PPP2R3C PP2A regulatory subunit B' HUGO:PPP2R4 HGNC:9308 ENTREZ:5524 UNIPROT:Q15257 GENECARDS:PPP2R4 KEGG:5524 ATLASONC:PPP2R4ID41817ch9q34 WIKI:PPP2R4 PP2A 56 kDa regulatory subunit alpha isoform HUGO:PPP2R5A HGNC:9309 ENTREZ:5525 UNIPROT:Q15172 GENECARDS:PPP2R5A REACTOME:49115 KEGG:5525 ATLASONC:GC_PPP2R5A WIKI:PPP2R5A PP2A 56 kDa regulatory subunit beta isoform HUGO:PPP2R5B HGNC:9310 ENTREZ:5526 UNIPROT:Q15173 GENECARDS:PPP2R5B REACTOME:405832 KEGG:5526 ATLASONC:GC_PPP2R5B WIKI:PPP2R5B PP2A 56 kDa regulatory subunit gamma isoform HUGO:PPP2R5C HGNC:9311 ENTREZ:5527 UNIPROT:Q13362 GENECARDS:PPP2R5C REACTOME:405599 KEGG:5527 ATLASONC:GC_PPP2R5C WIKI:PPP2R5C PP2A 56 kDa regulatory subunit delta isoform HUGO:PPP2R5D HGNC:9312 ENTREZ:5528 UNIPROT:Q14738 GENECARDS:PPP2R5D REACTOME:405743 KEGG:5528 ATLASONC:GC_PPP2R5D WIKI:PPP2R5D PP2A 56 kDa regulatory subunit epsilon isoform HUGO:PPP2R5E HGNC:9313 ENTREZ:5529 UNIPROT:Q16537 GENECARDS:PPP2R5E REACTOME:49121 ATLASONC:GC_PPP2R5E WIKI:PPP2R5E Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 References_end Identifiers_begin: protein phosphatase 2 regulatory subunit B alpha HUGO:PPP2R2A HGNC:9304 ENTREZ:5520 UNIPROT:P63151 GENECARDS:PPP2R2A REACTOME:49129 KEGG:5520 ATLASONC:GC_PPP2R2A WIKI:PPP2R2A P63151 protein phosphatase 2 regulatory subunit B beta HUGO:PPP2R2B HGNC:9305 ENTREZ:5521 UNIPROT:Q00005 GENECARDS:PPP2R2B KEGG:5521 ATLASONC:GC_PPP2R2B WIKI:PPP2R2B Q00005 protein phosphatase 2 regulatory subunit B gamma HUGO:PPP2R2C HGNC:9306 ENTREZ:5522 UNIPROT:Q9Y2T4 GENECARDS:PPP2R2C KEGG:5522 ATLASONC:GC_PPP2R2C WIKI:PPP2R2C Q9Y2T4 protein phosphatase 2 regulatory subunit B delta HUGO:PPP2R2D HGNC:23732 ENTREZ:55844 UNIPROT:Q66LE6 GENECARDS:PPP2R2D REACTOME:217408 KEGG:55844 ATLASONC:GC_PPP2R2D WIKI:PPP2R2D Q66LE6 PP2A 55 kDa regulatory subunit B beta isoform PP2A 55 kDa regulatory subunit B gamma isoform PP2A 55 kDa regulatory subunit B delta isoform PP2A 72/130 kDa regulatory subunit B HUGO:PPP2R3A HGNC:9307 ENTREZ:5523 UNIPROT:Q06190 GENECARDS:PPP2R3A KEGG:5523 ATLASONC:GC_PPP2R3A WIKI:PPP2R3A PP2A 48 kDa regulatory subunit B HUGO:PPP2R3B HGNC:13417 ENTREZ:28227 UNIPROT:Q9Y5P8 GENECARDS:PPP2R3B REACTOME:49140 KEGG:28227 ATLASONC:GC_PPP2R3B WIKI:PPP2R3B PP2A regulatory subunit B'' subunit gamma HUGO:PPP2R3C HGNC:17485 ENTREZ:55012 UNIPROT:Q969Q6 GENECARDS:PPP2R3C KEGG:55012 WIKI:PPP2R3C PP2A regulatory subunit B' HUGO:PPP2R4 HGNC:9308 ENTREZ:5524 UNIPROT:Q15257 GENECARDS:PPP2R4 KEGG:5524 ATLASONC:PPP2R4ID41817ch9q34 WIKI:PPP2R4 PP2A 56 kDa regulatory subunit alpha isoform HUGO:PPP2R5A HGNC:9309 ENTREZ:5525 UNIPROT:Q15172 GENECARDS:PPP2R5A REACTOME:49115 KEGG:5525 ATLASONC:GC_PPP2R5A WIKI:PPP2R5A PP2A 56 kDa regulatory subunit beta isoform HUGO:PPP2R5B HGNC:9310 ENTREZ:5526 UNIPROT:Q15173 GENECARDS:PPP2R5B REACTOME:405832 KEGG:5526 ATLASONC:GC_PPP2R5B WIKI:PPP2R5B PP2A 56 kDa regulatory subunit gamma isoform HUGO:PPP2R5C HGNC:9311 ENTREZ:5527 UNIPROT:Q13362 GENECARDS:PPP2R5C REACTOME:405599 KEGG:5527 ATLASONC:GC_PPP2R5C WIKI:PPP2R5C PP2A 56 kDa regulatory subunit delta isoform HUGO:PPP2R5D HGNC:9312 ENTREZ:5528 UNIPROT:Q14738 GENECARDS:PPP2R5D REACTOME:405743 KEGG:5528 ATLASONC:GC_PPP2R5D WIKI:PPP2R5D PP2A 56 kDa regulatory subunit epsilon isoform HUGO:PPP2R5E HGNC:9313 ENTREZ:5529 UNIPROT:Q16537 GENECARDS:PPP2R5E REACTOME:49121 ATLASONC:GC_PPP2R5E WIKI:PPP2R5E Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 References_end</body> </html> </notes> <label text="PP2A_B*"/> <clone/> <bbox w="80.0" h="40.0" x="5437.5" y="4212.5"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s442_akt1_akt2_csa10" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DAXX:PML:PP2A_A*:PP2A_B*:PP2A_C* Identifiers_end References_begin: s_akt2_re29(MAP:survival): PMID:16680151 PMID:20452955 PMID:19216069 References_end</body> </html> </notes> <label text="(PML_Nuclear_Body_PP2A)"/> <bbox w="198.0" h="253.0" x="5567.0" y="4333.0"/> <glyph class="macromolecule" id="akt1_akt2_s69_akt1_akt2_sa61"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: protein phosphatase 2 regulatory subunit A alpha HUGO:PPP2R1A HGNC:9302 ENTREZ:5518 UNIPROT:P30153 GENECARDS:PPP2R1A REACTOME:49125 KEGG:5518 ATLASONC:GC_PPP2R1A WIKI:PPP2R1A protein phosphatase 2 regulatory subunit B beta HUGO:PPP2R1B HGNC:9303 ENTREZ:5519 UNIPROT:P30154 GENECARDS:PPP2R1B REACTOME:49127 KEGG:5519 ATLASONC:GC_PPP2R1B WIKI:PPP2R1B PP2A-Aalpha, PR65A, "protein phosphatase 2, 65kDa regulatory subunit A", "protein phosphatase 2A, regulatory subunit A, alpha isoform" protein phosphatase 2, regulatory subunit A, beta Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18559511 PMID:10026142 Structural sub-unit References_end Identifiers_begin: protein phosphatase 2 regulatory subunit A alpha HUGO:PPP2R1A HGNC:9302 ENTREZ:5518 UNIPROT:P30153 GENECARDS:PPP2R1A REACTOME:49125 KEGG:5518 ATLASONC:GC_PPP2R1A WIKI:PPP2R1A protein phosphatase 2 regulatory subunit B beta HUGO:PPP2R1B HGNC:9303 ENTREZ:5519 UNIPROT:P30154 GENECARDS:PPP2R1B REACTOME:49127 KEGG:5519 ATLASONC:GC_PPP2R1B WIKI:PPP2R1B PP2A-Aalpha, PR65A, "protein phosphatase 2, 65kDa regulatory subunit A", "protein phosphatase 2A, regulatory subunit A, alpha isoform" protein phosphatase 2, regulatory subunit A, beta Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18559511 PMID:10026142 Structural sub-unit References_end</body> </html> Identifiers_begin: protein phosphatase 2 regulatory subunit A alpha HUGO:PPP2R1A HGNC:9302 ENTREZ:5518 UNIPROT:P30153 GENECARDS:PPP2R1A REACTOME:49125 KEGG:5518 ATLASONC:GC_PPP2R1A WIKI:PPP2R1A protein phosphatase 2 regulatory subunit B beta HUGO:PPP2R1B HGNC:9303 ENTREZ:5519 UNIPROT:P30154 GENECARDS:PPP2R1B REACTOME:49127 KEGG:5519 ATLASONC:GC_PPP2R1B WIKI:PPP2R1B PP2A-Aalpha, PR65A, "protein phosphatase 2, 65kDa regulatory subunit A", "protein phosphatase 2A, regulatory subunit A, alpha isoform" protein phosphatase 2, regulatory subunit A, beta Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18559511 PMID:10026142 Structural sub-unit References_end</body> </html> </notes> <label text="PP2A_A*"/> <bbox w="80.0" h="40.0" x="5582.5" y="4345.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s70_akt1_akt2_sa62"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 References_end Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> </notes> <label text="PP2A_C*"/> <bbox w="80.0" h="40.0" x="5584.5" y="4384.0"/> <glyph class="state variable" id="_4fc7e60f-e7b0-4bd3-9046-8a4d782a216f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5579.5" y="4399.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s71_akt1_akt2_sa63"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: protein phosphatase 2 regulatory subunit B alpha HUGO:PPP2R2A HGNC:9304 ENTREZ:5520 UNIPROT:P63151 GENECARDS:PPP2R2A REACTOME:49129 KEGG:5520 ATLASONC:GC_PPP2R2A WIKI:PPP2R2A P63151 protein phosphatase 2 regulatory subunit B beta HUGO:PPP2R2B HGNC:9305 ENTREZ:5521 UNIPROT:Q00005 GENECARDS:PPP2R2B KEGG:5521 ATLASONC:GC_PPP2R2B WIKI:PPP2R2B Q00005 protein phosphatase 2 regulatory subunit B gamma HUGO:PPP2R2C HGNC:9306 ENTREZ:5522 UNIPROT:Q9Y2T4 GENECARDS:PPP2R2C KEGG:5522 ATLASONC:GC_PPP2R2C WIKI:PPP2R2C Q9Y2T4 protein phosphatase 2 regulatory subunit B delta HUGO:PPP2R2D HGNC:23732 ENTREZ:55844 UNIPROT:Q66LE6 GENECARDS:PPP2R2D REACTOME:217408 KEGG:55844 ATLASONC:GC_PPP2R2D WIKI:PPP2R2D Q66LE6 PP2A 55 kDa regulatory subunit B beta isoform PP2A 55 kDa regulatory subunit B gamma isoform PP2A 55 kDa regulatory subunit B delta isoform PP2A 72/130 kDa regulatory subunit B HUGO:PPP2R3A HGNC:9307 ENTREZ:5523 UNIPROT:Q06190 GENECARDS:PPP2R3A KEGG:5523 ATLASONC:GC_PPP2R3A WIKI:PPP2R3A PP2A 48 kDa regulatory subunit B HUGO:PPP2R3B HGNC:13417 ENTREZ:28227 UNIPROT:Q9Y5P8 GENECARDS:PPP2R3B REACTOME:49140 KEGG:28227 ATLASONC:GC_PPP2R3B WIKI:PPP2R3B PP2A regulatory subunit B'' subunit gamma HUGO:PPP2R3C HGNC:17485 ENTREZ:55012 UNIPROT:Q969Q6 GENECARDS:PPP2R3C KEGG:55012 WIKI:PPP2R3C PP2A regulatory subunit B' HUGO:PPP2R4 HGNC:9308 ENTREZ:5524 UNIPROT:Q15257 GENECARDS:PPP2R4 KEGG:5524 ATLASONC:PPP2R4ID41817ch9q34 WIKI:PPP2R4 PP2A 56 kDa regulatory subunit alpha isoform HUGO:PPP2R5A HGNC:9309 ENTREZ:5525 UNIPROT:Q15172 GENECARDS:PPP2R5A REACTOME:49115 KEGG:5525 ATLASONC:GC_PPP2R5A WIKI:PPP2R5A PP2A 56 kDa regulatory subunit beta isoform HUGO:PPP2R5B HGNC:9310 ENTREZ:5526 UNIPROT:Q15173 GENECARDS:PPP2R5B REACTOME:405832 KEGG:5526 ATLASONC:GC_PPP2R5B WIKI:PPP2R5B PP2A 56 kDa regulatory subunit gamma isoform HUGO:PPP2R5C HGNC:9311 ENTREZ:5527 UNIPROT:Q13362 GENECARDS:PPP2R5C REACTOME:405599 KEGG:5527 ATLASONC:GC_PPP2R5C WIKI:PPP2R5C PP2A 56 kDa regulatory subunit delta isoform HUGO:PPP2R5D HGNC:9312 ENTREZ:5528 UNIPROT:Q14738 GENECARDS:PPP2R5D REACTOME:405743 KEGG:5528 ATLASONC:GC_PPP2R5D WIKI:PPP2R5D PP2A 56 kDa regulatory subunit epsilon isoform HUGO:PPP2R5E HGNC:9313 ENTREZ:5529 UNIPROT:Q16537 GENECARDS:PPP2R5E REACTOME:49121 ATLASONC:GC_PPP2R5E WIKI:PPP2R5E Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 References_end Identifiers_begin: protein phosphatase 2 regulatory subunit B alpha HUGO:PPP2R2A HGNC:9304 ENTREZ:5520 UNIPROT:P63151 GENECARDS:PPP2R2A REACTOME:49129 KEGG:5520 ATLASONC:GC_PPP2R2A WIKI:PPP2R2A P63151 protein phosphatase 2 regulatory subunit B beta HUGO:PPP2R2B HGNC:9305 ENTREZ:5521 UNIPROT:Q00005 GENECARDS:PPP2R2B KEGG:5521 ATLASONC:GC_PPP2R2B WIKI:PPP2R2B Q00005 protein phosphatase 2 regulatory subunit B gamma HUGO:PPP2R2C HGNC:9306 ENTREZ:5522 UNIPROT:Q9Y2T4 GENECARDS:PPP2R2C KEGG:5522 ATLASONC:GC_PPP2R2C WIKI:PPP2R2C Q9Y2T4 protein phosphatase 2 regulatory subunit B delta HUGO:PPP2R2D HGNC:23732 ENTREZ:55844 UNIPROT:Q66LE6 GENECARDS:PPP2R2D REACTOME:217408 KEGG:55844 ATLASONC:GC_PPP2R2D WIKI:PPP2R2D Q66LE6 PP2A 55 kDa regulatory subunit B beta isoform PP2A 55 kDa regulatory subunit B gamma isoform PP2A 55 kDa regulatory subunit B delta isoform PP2A 72/130 kDa regulatory subunit B HUGO:PPP2R3A HGNC:9307 ENTREZ:5523 UNIPROT:Q06190 GENECARDS:PPP2R3A KEGG:5523 ATLASONC:GC_PPP2R3A WIKI:PPP2R3A PP2A 48 kDa regulatory subunit B HUGO:PPP2R3B HGNC:13417 ENTREZ:28227 UNIPROT:Q9Y5P8 GENECARDS:PPP2R3B REACTOME:49140 KEGG:28227 ATLASONC:GC_PPP2R3B WIKI:PPP2R3B PP2A regulatory subunit B'' subunit gamma HUGO:PPP2R3C HGNC:17485 ENTREZ:55012 UNIPROT:Q969Q6 GENECARDS:PPP2R3C KEGG:55012 WIKI:PPP2R3C PP2A regulatory subunit B' HUGO:PPP2R4 HGNC:9308 ENTREZ:5524 UNIPROT:Q15257 GENECARDS:PPP2R4 KEGG:5524 ATLASONC:PPP2R4ID41817ch9q34 WIKI:PPP2R4 PP2A 56 kDa regulatory subunit alpha isoform HUGO:PPP2R5A HGNC:9309 ENTREZ:5525 UNIPROT:Q15172 GENECARDS:PPP2R5A REACTOME:49115 KEGG:5525 ATLASONC:GC_PPP2R5A WIKI:PPP2R5A PP2A 56 kDa regulatory subunit beta isoform HUGO:PPP2R5B HGNC:9310 ENTREZ:5526 UNIPROT:Q15173 GENECARDS:PPP2R5B REACTOME:405832 KEGG:5526 ATLASONC:GC_PPP2R5B WIKI:PPP2R5B PP2A 56 kDa regulatory subunit gamma isoform HUGO:PPP2R5C HGNC:9311 ENTREZ:5527 UNIPROT:Q13362 GENECARDS:PPP2R5C REACTOME:405599 KEGG:5527 ATLASONC:GC_PPP2R5C WIKI:PPP2R5C PP2A 56 kDa regulatory subunit delta isoform HUGO:PPP2R5D HGNC:9312 ENTREZ:5528 UNIPROT:Q14738 GENECARDS:PPP2R5D REACTOME:405743 KEGG:5528 ATLASONC:GC_PPP2R5D WIKI:PPP2R5D PP2A 56 kDa regulatory subunit epsilon isoform HUGO:PPP2R5E HGNC:9313 ENTREZ:5529 UNIPROT:Q16537 GENECARDS:PPP2R5E REACTOME:49121 ATLASONC:GC_PPP2R5E WIKI:PPP2R5E Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 References_end</body> </html> </notes> <label text="PP2A_B*"/> <bbox w="80.0" h="40.0" x="5588.5" y="4425.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s443_akt1_akt2_sa64"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end</body> </html> </notes> <label text="PML"/> <bbox w="80.0" h="40.0" x="5577.5" y="4462.0"/> <glyph class="state variable" id="_11ee0c1a-3ecf-4c04-92f0-ade1dcf4a246"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5652.5" y="4457.0"/> </glyph> <glyph class="state variable" id="_13aaf218-c365-4c4f-938e-072d65ebf5ca"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5652.5" y="4497.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s443_akt1_akt2_sa65"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end</body> </html> </notes> <label text="PML"/> <bbox w="80.0" h="40.0" x="5587.5" y="4472.0"/> <glyph class="state variable" id="_168eacac-361d-4c33-a29f-939cf9b96c9b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5662.5" y="4467.0"/> </glyph> <glyph class="state variable" id="_0d806afb-fe54-456f-85be-2f593c0f0cb9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5662.5" y="4507.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s443_akt1_akt2_sa66"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end</body> </html> </notes> <label text="PML"/> <bbox w="80.0" h="40.0" x="5597.5" y="4482.0"/> <glyph class="state variable" id="_b9f59da8-644a-47b5-bb7d-8caa640514cc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5672.5" y="4477.0"/> </glyph> <glyph class="state variable" id="_1d1b4d35-c056-4aad-b5dd-d359a04ab833"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5672.5" y="4517.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s443_akt1_akt2_sa67"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end</body> </html> </notes> <label text="PML"/> <bbox w="80.0" h="40.0" x="5607.5" y="4492.0"/> <glyph class="state variable" id="_693c6585-b1fe-4bb6-9114-c41c5e62f164"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5682.5" y="4487.0"/> </glyph> <glyph class="state variable" id="_9fc32cc8-52a3-47f3-b73a-24b660b26dee"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5682.5" y="4527.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s443_akt1_akt2_sa68"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end</body> </html> </notes> <label text="PML"/> <bbox w="80.0" h="40.0" x="5617.5" y="4502.0"/> <glyph class="state variable" id="_46ef6036-4f64-4c1d-b8f6-9dc9cdd88c0c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5692.5" y="4497.0"/> </glyph> <glyph class="state variable" id="_385a74b1-bfda-43af-bf46-7f35bb1783e0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5692.5" y="4537.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s443_akt1_akt2_sa69"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end</body> </html> </notes> <label text="PML"/> <bbox w="80.0" h="40.0" x="5627.5" y="4512.0"/> <glyph class="state variable" id="_da4e45b7-0cd8-400a-b75d-d4cda37dac84"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5702.5" y="4507.0"/> </glyph> <glyph class="state variable" id="_4e96c741-8c13-406f-9271-c7e029a45ea0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5702.5" y="4547.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s76_akt1_akt2_sa70"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: death-domain associated protein HUGO:DAXX HGNC:2681 ENTREZ:1616 UNIPROT:Q9UER7 GENECARDS:DAXX KEGG:1616 ATLASONC:DAXXID40265ch6p21 WIKI:DAXX "death-associated protein 6" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 PMID:16406523 References_end Identifiers_begin: death-domain associated protein HUGO:DAXX HGNC:2681 ENTREZ:1616 UNIPROT:Q9UER7 GENECARDS:DAXX KEGG:1616 ATLASONC:DAXXID40265ch6p21 WIKI:DAXX "death-associated protein 6" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 PMID:16406523 References_end</body> </html> </notes> <label text="DAXX"/> <bbox w="80.0" h="40.0" x="5664.5" y="4346.0"/> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s444_akt1_akt2_csa6" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DAXX:PML Identifiers_end References_begin: s_akt2_re17:(MAP:survival) PMID:18716620 s_akt2_re27(MAP:survival): PMID:16680151 PMID:20452955 PMID:19216069 References_end</body> </html> </notes> <label text="(PML_Nuclear_Body)"/> <bbox w="216.0" h="127.0" x="5682.0" y="4153.0"/> <glyph class="macromolecule" id="akt1_akt2_s45_akt1_akt2_sa40"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: death-domain associated protein HUGO:DAXX HGNC:2681 ENTREZ:1616 UNIPROT:Q9UER7 GENECARDS:DAXX KEGG:1616 ATLASONC:DAXXID40265ch6p21 WIKI:DAXX "death-associated protein 6" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 PMID:16406523 References_end Identifiers_begin: death-domain associated protein HUGO:DAXX HGNC:2681 ENTREZ:1616 UNIPROT:Q9UER7 GENECARDS:DAXX KEGG:1616 ATLASONC:DAXXID40265ch6p21 WIKI:DAXX "death-associated protein 6" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 PMID:16406523 References_end</body> </html> </notes> <label text="DAXX"/> <bbox w="80.0" h="40.0" x="5804.0" y="4167.0"/> </glyph> <glyph class="macromolecule" id="akt1_akt2_s445_akt1_akt2_sa48"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end</body> </html> </notes> <label text="PML"/> <bbox w="80.0" h="40.0" x="5687.5" y="4163.0"/> <glyph class="state variable" id="_518f3e21-5dc5-4f9b-9401-8199d31fd1ea"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5762.5" y="4158.0"/> </glyph> <glyph class="state variable" id="_e8d9f9b5-fa4d-42d5-a80c-880602385556"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5762.5" y="4198.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s445_akt1_akt2_sa49"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end</body> </html> </notes> <label text="PML"/> <bbox w="80.0" h="40.0" x="5697.5" y="4173.0"/> <glyph class="state variable" id="_6d8a5b15-b45a-4740-894b-096499b00582"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5772.5" y="4168.0"/> </glyph> <glyph class="state variable" id="_99d3cc42-98e7-4a2a-8df3-17edfe1bf1f0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5772.5" y="4208.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s445_akt1_akt2_sa50"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end</body> </html> </notes> <label text="PML"/> <bbox w="80.0" h="40.0" x="5707.5" y="4183.0"/> <glyph class="state variable" id="_4bdfb3b0-f520-403f-9945-09b6e601c5a2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5782.5" y="4178.0"/> </glyph> <glyph class="state variable" id="_a2118b77-676c-4265-8135-34d599eec852"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5782.5" y="4218.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s445_akt1_akt2_sa51"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end</body> </html> </notes> <label text="PML"/> <bbox w="80.0" h="40.0" x="5717.5" y="4193.0"/> <glyph class="state variable" id="_ed0c6102-bdee-4847-8fd4-bc456fe1a2c8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5792.5" y="4188.0"/> </glyph> <glyph class="state variable" id="_23a20321-5550-4773-b8bd-3d7c027068d8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5792.5" y="4228.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s445_akt1_akt2_sa52"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end</body> </html> </notes> <label text="PML"/> <bbox w="80.0" h="40.0" x="5727.5" y="4203.0"/> <glyph class="state variable" id="_447b511d-186a-47cb-ba99-d69ffdc61910"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5802.5" y="4198.0"/> </glyph> <glyph class="state variable" id="_878c3362-7a4b-47e7-9c78-48ef00780a26"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5802.5" y="4238.0"/> </glyph> </glyph> <glyph class="macromolecule" id="akt1_akt2_s445_akt1_akt2_sa53"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end</body> </html> </notes> <label text="PML"/> <bbox w="80.0" h="40.0" x="5737.5" y="4213.0"/> <glyph class="state variable" id="_1c12881f-0c01-45b2-b0e7-752831e968fe"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5812.5" y="4208.0"/> </glyph> <glyph class="state variable" id="_878f43db-7c49-4352-b3e0-076abdf0e30b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="5812.5" y="4248.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="akt1_s_akt2_s446_akt1_akt2_csa54" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:RUNX2:promoter_region Identifiers_end References_begin: s_akt2_re157:(MAP:survival) PMID:20580290 References_end</body> </html> </notes> <label text="(Runx2_gene)"/> <bbox w="100.0" h="120.0" x="6430.0" y="3932.0"/> <glyph class="macromolecule" id="akt1_akt2_s431_akt1_akt2_sa311"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Runt-related transcription factor 2 HUGO:RUNX2 HGNC:10472 ENTREZ:860 UNIPROT:Q13950 GENECARDS:RUNX2 REACTOME:63858 KEGG:860 ATLASONC:RUNX2ID42183ch6p21 WIKI:RUNX2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20946121 PMID:20580290 References_end</body> </html> </notes> <label text="RUNX2"/> <bbox w="80.0" h="40.0" x="6438.25" y="3947.0"/> </glyph> <glyph class="nucleic acid feature" id="akt1_akt2_s430_akt1_akt2_sa312"> <label text="promoter_region"/> <bbox w="70.0" h="25.0" x="6443.5" y="4001.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s350_akt1_akt2_sa250" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re132:(MAP:survival) PMID:19574223 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 27a HUGO:MIR27A HGNC:31613 ENTREZ:407018 GENECARDS:MIR27A KEGG:407018 ATLASONC:MIR27AID50398ch19p13 WIKI:MIR27A Identifiers_end References_begin: PMID:19574223 References_end</body> </html> </notes> <label text="MIR27A"/> <bbox w="90.0" h="25.0" x="5078.5" y="4258.5"/> <glyph class="unit of information" id="_e2b22f17-45a2-443f-839d-c97a522ba1e0"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="5108.5" y="4253.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s351_akt1_akt2_sa251" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re133:(MAP:survival) PMID:19574223 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 96 HUGO:MIR96 HGNC:31648 ENTREZ:407053 GENECARDS:MIR96 KEGG:407053 ATLASONC:GC_MIR96 WIKI:MIR96 Identifiers_end References_begin: PMID:19574223 References_end</body> </html> </notes> <label text="MIR96"/> <bbox w="90.0" h="25.0" x="5188.0" y="4258.5"/> <glyph class="unit of information" id="_a0faf0d6-c767-462b-8111-84cbf071e324"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="5218.0" y="4253.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s352_akt1_akt2_sa252" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re134:(MAP:survival) PMID:19574223 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES Maps_Modules_end</body> </html> </notes> <label text="MIR182"/> <bbox w="90.0" h="25.0" x="5299.0" y="4258.5"/> <glyph class="unit of information" id="_fd6cc8a4-4fdf-43d8-8687-dc2898e4ca85"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="5329.0" y="4253.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="akt1_s_akt2_s414_akt1_akt2_sa304" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re156:(MAP:survival) PMID:18199536 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 214 HUGO:MIR214 HGNC:31591 ENTREZ:406996 GENECARDS:MIR214 KEGG:406996 ATLASONC:GC_MIR214 WIKI:MIR214 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES Maps_Modules_end References_begin: PMID:20083225 References_end</body> </html> </notes> <label text="MIR214"/> <bbox w="90.0" h="25.0" x="4820.5" y="4432.5"/> <glyph class="unit of information" id="_302effd3-53cc-4276-951b-a098d9b283a6"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="4850.5" y="4427.5"/> </glyph> </glyph> <glyph class="phenotype" id="akt1_s_akt2_s46_akt1_akt2_sa41" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_akt2_re18(MAP:survival): PMID:17218262 PMID:17218252 References_end</body> </html> </notes> <label text="Chromosome integrity and DSB repair"/> <bbox w="80.0" h="30.0" x="5574.25" y="3827.0"/> </glyph> <glyph class="unspecified entity" id="akt1_s_akt2_s83_akt1_akt2_sa78" compartmentRef="akt1_akt2_c2_akt1_akt2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re8(MAP:survival): MEK/ERK cascade activation is the upstream signal required for phosphorylation. PMID:21751375 References_end</body> </html> </notes> <label text="Unknown kinase"/> <bbox w="70.0" h="25.0" x="5678.0" y="3115.5"/> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc1_s29_wnc1_wnc1_sa36" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re62(MAP:survival): Cthrc1 enhances formation of Wnt-Fzl-Ror2 complex PMID:12839624 PMID:18606138 Syndecan-4 binds to Fzl, Dvl and is required for PCP MODULE. PMID:16604063 PMID:21397842 Vangl-2 forms complex upon binding with Wnt-5 PMID:21316585 ROR2 is associated with Wnt, Fzl and CK1_epsilon PMID:20215527 PPR binds to Fzl in both canonical and non-canonical MODULE PMID:20093472 PMID:21380625 PMID:20579883 References_end</body> </html> </notes> <label text="GDP"/> <clone/> <bbox w="25.0" h="25.0" x="7617.0" y="392.5"/> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc1_s29_wnc1_wnc1_sa156" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re62(MAP:survival): Cthrc1 enhances formation of Wnt-Fzl-Ror2 complex PMID:12839624 PMID:18606138 Syndecan-4 binds to Fzl, Dvl and is required for PCP MODULE. PMID:16604063 PMID:21397842 Vangl-2 forms complex upon binding with Wnt-5 PMID:21316585 ROR2 is associated with Wnt, Fzl and CK1_epsilon PMID:20215527 PPR binds to Fzl in both canonical and non-canonical MODULE PMID:20093472 PMID:21380625 PMID:20579883 References_end</body> </html> </notes> <label text="GDP"/> <clone/> <bbox w="25.0" h="25.0" x="9229.5" y="347.5"/> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc1_s29_wnc1_wnc1_sa160" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re62(MAP:survival): Cthrc1 enhances formation of Wnt-Fzl-Ror2 complex PMID:12839624 PMID:18606138 Syndecan-4 binds to Fzl, Dvl and is required for PCP MODULE. PMID:16604063 PMID:21397842 Vangl-2 forms complex upon binding with Wnt-5 PMID:21316585 ROR2 is associated with Wnt, Fzl and CK1_epsilon PMID:20215527 PPR binds to Fzl in both canonical and non-canonical MODULE PMID:20093472 PMID:21380625 PMID:20579883 References_end</body> </html> </notes> <label text="GDP"/> <clone/> <bbox w="25.0" h="25.0" x="8979.5" y="357.5"/> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc1_s29_wnc1_wnc1_sa196" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re62(MAP:survival): Cthrc1 enhances formation of Wnt-Fzl-Ror2 complex PMID:12839624 PMID:18606138 Syndecan-4 binds to Fzl, Dvl and is required for PCP MODULE. PMID:16604063 PMID:21397842 Vangl-2 forms complex upon binding with Wnt-5 PMID:21316585 ROR2 is associated with Wnt, Fzl and CK1_epsilon PMID:20215527 PPR binds to Fzl in both canonical and non-canonical MODULE PMID:20093472 PMID:21380625 PMID:20579883 References_end</body> </html> </notes> <label text="GDP"/> <clone/> <bbox w="25.0" h="25.0" x="9269.5" y="1067.5"/> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc1_s29_wnc1_wnc1_sa246" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re62(MAP:survival): Cthrc1 enhances formation of Wnt-Fzl-Ror2 complex PMID:12839624 PMID:18606138 Syndecan-4 binds to Fzl, Dvl and is required for PCP MODULE. PMID:16604063 PMID:21397842 Vangl-2 forms complex upon binding with Wnt-5 PMID:21316585 ROR2 is associated with Wnt, Fzl and CK1_epsilon PMID:20215527 PPR binds to Fzl in both canonical and non-canonical MODULE PMID:20093472 PMID:21380625 PMID:20579883 References_end</body> </html> </notes> <label text="GDP"/> <clone/> <bbox w="25.0" h="25.0" x="9294.5" y="1552.0"/> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc1_s30_wnc1_wnc1_sa29" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re62(MAP:survival): Cthrc1 enhances formation of Wnt-Fzl-Ror2 complex PMID:12839624 PMID:18606138 Syndecan-4 binds to Fzl, Dvl and is required for PCP MODULE. PMID:16604063 PMID:21397842 Vangl-2 forms complex upon binding with Wnt-5 PMID:21316585 ROR2 is associated with Wnt, Fzl and CK1_epsilon PMID:20215527 PPR binds to Fzl in both canonical and non-canonical MODULE PMID:20093472 PMID:21380625 PMID:20579883 References_end</body> </html> </notes> <label text="GTP"/> <clone/> <bbox w="25.0" h="25.0" x="7556.0" y="392.5"/> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc1_s30_wnc1_wnc1_sa125" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re62(MAP:survival): Cthrc1 enhances formation of Wnt-Fzl-Ror2 complex PMID:12839624 PMID:18606138 Syndecan-4 binds to Fzl, Dvl and is required for PCP MODULE. PMID:16604063 PMID:21397842 Vangl-2 forms complex upon binding with Wnt-5 PMID:21316585 ROR2 is associated with Wnt, Fzl and CK1_epsilon PMID:20215527 PPR binds to Fzl in both canonical and non-canonical MODULE PMID:20093472 PMID:21380625 PMID:20579883 References_end</body> </html> </notes> <label text="GTP"/> <clone/> <bbox w="25.0" h="25.0" x="7219.5" y="667.5"/> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc1_s30_wnc1_wnc1_sa158" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re62(MAP:survival): Cthrc1 enhances formation of Wnt-Fzl-Ror2 complex PMID:12839624 PMID:18606138 Syndecan-4 binds to Fzl, Dvl and is required for PCP MODULE. PMID:16604063 PMID:21397842 Vangl-2 forms complex upon binding with Wnt-5 PMID:21316585 ROR2 is associated with Wnt, Fzl and CK1_epsilon PMID:20215527 PPR binds to Fzl in both canonical and non-canonical MODULE PMID:20093472 PMID:21380625 PMID:20579883 References_end</body> </html> </notes> <label text="GTP"/> <clone/> <bbox w="25.0" h="25.0" x="9029.5" y="347.5"/> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc1_s30_wnc1_wnc1_sa159" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re62(MAP:survival): Cthrc1 enhances formation of Wnt-Fzl-Ror2 complex PMID:12839624 PMID:18606138 Syndecan-4 binds to Fzl, Dvl and is required for PCP MODULE. PMID:16604063 PMID:21397842 Vangl-2 forms complex upon binding with Wnt-5 PMID:21316585 ROR2 is associated with Wnt, Fzl and CK1_epsilon PMID:20215527 PPR binds to Fzl in both canonical and non-canonical MODULE PMID:20093472 PMID:21380625 PMID:20579883 References_end</body> </html> </notes> <label text="GTP"/> <clone/> <bbox w="25.0" h="25.0" x="8929.5" y="357.5"/> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc1_s30_wnc1_wnc1_sa197" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re62(MAP:survival): Cthrc1 enhances formation of Wnt-Fzl-Ror2 complex PMID:12839624 PMID:18606138 Syndecan-4 binds to Fzl, Dvl and is required for PCP MODULE. PMID:16604063 PMID:21397842 Vangl-2 forms complex upon binding with Wnt-5 PMID:21316585 ROR2 is associated with Wnt, Fzl and CK1_epsilon PMID:20215527 PPR binds to Fzl in both canonical and non-canonical MODULE PMID:20093472 PMID:21380625 PMID:20579883 References_end</body> </html> </notes> <label text="GTP"/> <clone/> <bbox w="25.0" h="25.0" x="9269.5" y="987.5"/> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc1_s30_wnc1_wnc1_sa245" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re62(MAP:survival): Cthrc1 enhances formation of Wnt-Fzl-Ror2 complex PMID:12839624 PMID:18606138 Syndecan-4 binds to Fzl, Dvl and is required for PCP MODULE. PMID:16604063 PMID:21397842 Vangl-2 forms complex upon binding with Wnt-5 PMID:21316585 ROR2 is associated with Wnt, Fzl and CK1_epsilon PMID:20215527 PPR binds to Fzl in both canonical and non-canonical MODULE PMID:20093472 PMID:21380625 PMID:20579883 References_end</body> </html> </notes> <label text="GTP"/> <clone/> <bbox w="25.0" h="25.0" x="9297.5" y="1480.0"/> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc1_s125_wnc1_wnc1_sa109" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Ca2+/Wnt MODULE s_wnc1_re26:(MAP:survival) PMID:16054198 References_end</body> </html> </notes> <label text="IP3"/> <bbox w="70.0" h="25.0" x="7427.0" y="837.5"/> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc1_s126_wnc1_wnc1_sa110" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Ca2+/Wnt MODULE s_wnc1_re26:(MAP:survival) PMID:16054198 References_end</body> </html> </notes> <label text="DAG"/> <bbox w="70.0" h="25.0" x="7302.0" y="837.5"/> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc1_s181_wnc1_wnc1_sa148"> <label text="PTH"/> <bbox w="70.0" h="25.0" x="8937.0" y="197.5"/> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc1_s220_wnc1_wnc1_sa172" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <label text="ATP"/> <bbox w="70.0" h="25.0" x="9107.0" y="607.5"/> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc1_s221_wnc1_wnc1_sa173" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <label text="cAMP"/> <bbox w="70.0" h="25.0" x="9107.0" y="687.5"/> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc1_s124_wnc1_wnc1_sa108" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Same molecule as in AKT MODULE. Membrane-bound s_wnc1_re26:(MAP:survival) PMID:16054198 References_end</body> </html> </notes> <label text="PI4,5-P2"/> <bbox w="70.0" h="25.0" x="7359.0" y="730.5"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s1_wnc1_wnc1_sa1" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re1(MAP:survival): PMID:21506126 PAR1 can induce AKT phosphorylation; exact mechanism unknown also wich residues are unknown PMID:17374729 s_wnc1_re23:(MAP:survival) PMID:9859994 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:cellcycle / MODULE:CYCLIND MAP:cellcycle / MODULE:P21CIP MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:cellcycle / MODULE:CYCLIND MAP:cellcycle / MODULE:P21CIP MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end</body> </html> </notes> <label text="AKT1"/> <bbox w="80.0" h="40.0" x="7878.0" y="513.0"/> <glyph class="state variable" id="_eda1591a-f625-44f2-9e58-4589f60e6257"> <state value="" variable="T308"/> <bbox w="30.0" h="10.0" x="7863.0" y="511.77402"/> </glyph> <glyph class="state variable" id="_60837b5b-4245-4a05-978f-c1ae48c7afb4"> <state value="" variable="T450"/> <bbox w="30.0" h="10.0" x="7942.6333" y="508.0"/> </glyph> <glyph class="state variable" id="_3efc2163-e695-42a9-835d-4cbf7ae127b3"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="7943.0" y="547.1307"/> </glyph> <glyph class="state variable" id="_6b9e62f7-f69a-41e4-9521-36114c5198ab"> <state value="" variable="S129"/> <bbox w="30.0" h="10.0" x="7863.0" y="544.1206"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s2_wnc1_wnc1_sa2" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re1(MAP:survival): PMID:21506126 PAR1 can induce AKT phosphorylation; exact mechanism unknown also wich residues are unknown PMID:17374729 s_wnc1_re2(MAP:survival): Phosphorylation of beta-catenin is through an indirect mechanism which is unknown PMID:21303971 Path to phosphorylation of b-catenin is not completely depicted here. For full paths see AKT-MODULE References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:cellcycle / MODULE:CYCLIND MAP:cellcycle / MODULE:P21CIP MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:cellcycle / MODULE:CYCLIND MAP:cellcycle / MODULE:P21CIP MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end</body> </html> </notes> <label text="AKT1"/> <bbox w="80.0" h="40.0" x="8036.5" y="513.0"/> <glyph class="state variable" id="_a36ed821-3860-4687-a951-d2904d8b8566"> <state value="" variable="T308"/> <bbox w="30.0" h="10.0" x="8021.5" y="511.77402"/> </glyph> <glyph class="state variable" id="_0091feaf-472a-4407-b8c1-3a8c915df59f"> <state value="" variable="T450"/> <bbox w="30.0" h="10.0" x="8101.1333" y="508.0"/> </glyph> <glyph class="state variable" id="_5fc13fca-8eb1-4f3e-ac2a-eacf14456079"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="8101.5" y="547.1307"/> </glyph> <glyph class="state variable" id="_74aee0d8-b2ac-44cc-b3f5-97a9aebe0f1b"> <state value="" variable="S129"/> <bbox w="30.0" h="10.0" x="8021.5" y="544.1206"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s6_wnc1_wnc1_sa5" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="8132.0" y="429.0"/> <glyph class="state variable" id="_f0fe8e57-72e5-4c79-bd82-bd43206fb984"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="8159.4043" y="464.0"/> </glyph> <glyph class="state variable" id="_a4a0b17e-6fec-4bc1-93d3-11693838f0e2"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="8198.882" y="464.0"/> </glyph> <glyph class="state variable" id="_fb813b08-b577-4bc8-bd9b-e439a1bfee49"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="8199.5" y="424.21478"/> </glyph> <glyph class="state variable" id="_bb78c467-9e61-4877-9750-f3bba3375c6c"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="8159.5317" y="424.0"/> </glyph> <glyph class="state variable" id="_fe7f0925-9ecc-4c94-b1b2-3943e2e4a804"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="8119.9927" y="424.0"/> </glyph> <glyph class="state variable" id="_72610405-bb88-4e33-bbb3-4c5ef7de88ba"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="8119.5" y="463.7223"/> </glyph> <glyph class="state variable" id="_2441ac66-fded-43ca-b020-d820918ebb89"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="8197.0" y="424.21478"/> </glyph> <glyph class="state variable" id="_b4a0a10d-7d1c-4238-836d-8ae92dc617c4"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="8197.0" y="424.21478"/> </glyph> <glyph class="state variable" id="_5050f8bd-0f4b-441a-8458-515ff41fb817"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8127.0" y="444.0"/> </glyph> <glyph class="state variable" id="_0f967ad1-95a7-4897-aa25-8df885a7782e"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="8117.4927" y="424.0"/> </glyph> <glyph class="state variable" id="_d8853184-e5e1-4a81-94a8-50711757fd1a"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="8197.0" y="424.21478"/> </glyph> <glyph class="state variable" id="_e3cdc138-b451-4cac-bb92-339092855cac"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8127.0" y="435.71573"/> </glyph> <glyph class="state variable" id="_d4c22563-da29-4525-940a-ab42cafcb49f"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="8197.0" y="424.21478"/> </glyph> <glyph class="state variable" id="_05a62512-98f0-4067-9c75-0dd3b69ed52c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8127.0" y="444.0"/> </glyph> <glyph class="state variable" id="_121ace3e-35fa-49e2-8875-600b98a79b02"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="8196.382" y="464.0"/> </glyph> <glyph class="state variable" id="_037fdc75-978f-4356-a034-cc47b6cdd845"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="8197.0" y="424.21478"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s7_wnc1_wnc1_sa6" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re2(MAP:survival): PMID:21506126 Phosphorylation of beta-catenin is through an indirect mechanism which is unknown PMID:21303971 Path to phosphorylation of b-catenin is not completely depicted here. For full paths see AKT-MODULE References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="8132.0" y="597.0"/> <glyph class="state variable" id="_3665685e-b0d2-4dec-b067-f88367e13257"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="8159.4043" y="632.0"/> </glyph> <glyph class="state variable" id="_5858e8aa-d2cd-4893-b4d9-db4aabc33f84"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="8198.882" y="632.0"/> </glyph> <glyph class="state variable" id="_0324bdfc-eb8a-4f3f-b018-e46e80cc7051"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="8199.5" y="592.2148"/> </glyph> <glyph class="state variable" id="_d01e5793-5ccd-4794-a533-af551abee0ca"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="8159.5317" y="592.0"/> </glyph> <glyph class="state variable" id="_03e47dbe-a572-4cec-9756-d546401f8acd"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="8119.9927" y="592.0"/> </glyph> <glyph class="state variable" id="_377a5f80-bb73-410f-aa1a-1550c342a18f"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="8119.5" y="631.7223"/> </glyph> <glyph class="state variable" id="_4b29fa45-e990-4483-9d98-61b11cdd660c"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="8197.0" y="592.2148"/> </glyph> <glyph class="state variable" id="_abc9ecd5-0abf-4187-82fa-a0c754c478b1"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="8197.0" y="592.2148"/> </glyph> <glyph class="state variable" id="_f8919a74-5198-4779-bb03-371b5dc95cbc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8127.0" y="612.0"/> </glyph> <glyph class="state variable" id="_8c06d9b1-cf69-4b12-8a1f-659ec92fee1f"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="8117.4927" y="592.0"/> </glyph> <glyph class="state variable" id="_70844dd1-e0c6-4aa9-b86a-67b8d5c7dc3b"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="8197.0" y="592.2148"/> </glyph> <glyph class="state variable" id="_3d5f9808-18fd-4028-8058-d66b224ff5f1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8127.0" y="603.7157"/> </glyph> <glyph class="state variable" id="_5a4617f1-8842-499e-a73d-627d7c6cb650"> <state value="P" variable="S522"/> <bbox w="35.0" h="10.0" x="8194.5" y="592.2148"/> </glyph> <glyph class="state variable" id="_dec226ba-1853-4bb8-85ff-212a15e3a570"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8127.0" y="612.0"/> </glyph> <glyph class="state variable" id="_a9bd6bef-6602-449e-91ef-751a169cf68d"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="8196.382" y="632.0"/> </glyph> <glyph class="state variable" id="_9f897ec7-b725-49e1-bbce-bcfab2bde1f6"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="8197.0" y="592.2148"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s10_wnc1_wnc1_sa9" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re2(MAP:survival): PMID:21506126 Phosphorylation of beta-catenin is through an indirect mechanism which is unknown PMID:21303971 Path to phosphorylation of b-catenin is not completely depicted here. For full paths see AKT-MODULE References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphatidylinositol-4-phosphate 5-kinase, type I, gamma HUGO:PIP5KIC GENECARDS:PIP5KIC WIKI:PIP5KIC HUGO:PIP5K1C HGNC:8996 ENTREZ:23396 UNIPROT:O60331 GENECARDS:PIP5K1C REACTOME:242749 KEGG:23396 ATLASONC:GC_PIP5K1C WIKI:PIP5K1C Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PIPKIγi2*"/> <bbox w="80.0" h="40.0" x="8277.0" y="595.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s13_wnc1_wnc1_sa55" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re65(MAP:survival): Active PKC phosphorylates Dvl, just not enough to achieve the PS-form. PMID:12958364 s_wnc1_re95:(MAP:survival) PMID:16446366 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <clone/> <bbox w="80.0" h="40.0" x="7772.75" y="665.0"/> <glyph class="state variable" id="_d4b99888-a5c6-414c-b4d5-59480ab28224"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7847.75" y="660.0"/> </glyph> <glyph class="state variable" id="_ff85590e-bf0c-4702-95b8-c8531420885c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7767.75" y="660.0"/> </glyph> <glyph class="state variable" id="_1be8fc14-133d-462b-a23e-a50686b2f5c3"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="7837.132" y="700.0"/> </glyph> <glyph class="state variable" id="_1e2e32fc-ba5a-4907-92e6-25e12972dcc3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7767.75" y="660.0"/> </glyph> <glyph class="state variable" id="_f2b696d0-f8a1-46ba-b6a7-1f7e6a986c03"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7847.75" y="660.0"/> </glyph> <glyph class="state variable" id="_aceeddfa-92f9-4c0e-b2d7-a50d947c29b4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7847.3833" y="660.0"/> </glyph> <glyph class="state variable" id="_ff4ead00-d447-48e5-ba04-e728330fd5cc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7847.75" y="700.0"/> </glyph> <glyph class="state variable" id="_de255876-1db0-441f-8d57-cad3b2b37706"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="7757.75" y="699.7223"/> </glyph> <glyph class="state variable" id="_a912f66c-d551-4ec2-b417-0c6a7298242b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7767.75" y="700.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s13_wnc1_wnc1_sa256" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re65(MAP:survival): Active PKC phosphorylates Dvl, just not enough to achieve the PS-form. PMID:12958364 s_wnc1_re95:(MAP:survival) PMID:16446366 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <clone/> <bbox w="80.0" h="40.0" x="9178.0" y="1844.0"/> <glyph class="state variable" id="_1c21daba-c474-401c-a5f0-18537176faf4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9253.0" y="1839.0"/> </glyph> <glyph class="state variable" id="_edef12ea-dbaf-4666-8bb3-c87d0400233f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9173.0" y="1839.0"/> </glyph> <glyph class="state variable" id="_b97c77c0-0f63-4608-8875-16828069cca9"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="9242.382" y="1879.0"/> </glyph> <glyph class="state variable" id="_3a3d7ee4-4f73-4ea7-959e-7397ae9c0a11"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9173.0" y="1839.0"/> </glyph> <glyph class="state variable" id="_cae6be1b-e45d-4a95-8242-a1541f7b42ed"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9253.0" y="1839.0"/> </glyph> <glyph class="state variable" id="_ade7b367-dcd1-4a25-80c8-1036f0978772"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9252.634" y="1839.0"/> </glyph> <glyph class="state variable" id="_49bf7fa7-73d7-4edc-b843-a03a625424e3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9253.0" y="1879.0"/> </glyph> <glyph class="state variable" id="_c0a2b099-b337-427f-91e7-3941b40fb62b"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="9163.0" y="1878.7223"/> </glyph> <glyph class="state variable" id="_bdab24e5-9bae-41fc-9cce-366ec092aff0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9173.0" y="1879.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s15_wnc1_wnc1_sa15"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re7(MAP:survival): PAR1 is activated by cleavage of exodomain at Arg41-Ser42 PMID:14652070 PAR1 can be activated by MMP1 PMID:15707890 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: matrix metallopeptidase 1 (interstitial collagenase) CLG, "matrix metalloproteinase 1 (interstitial collagenase)" HUGO:MMP1 HGNC:7155 ENTREZ:4312 UNIPROT:P03956 GENECARDS:MMP1 REACTOME:59385 KEGG:4312 ATLASONC:GC_MMP1 WIKI:MMP1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:ECM MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Secreted by stroma cells References_end</body> </html> </notes> <label text="MMP1"/> <bbox w="80.0" h="40.0" x="7296.0" y="164.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s16_wnc1_wnc1_sa16"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re7(MAP:survival): PAR1 is activated by cleavage of exodomain at Arg41-Ser42 PMID:14652070 PAR1 can be activated by MMP1 PMID:15707890 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: coagulation factor II (thrombin) HUGO:F2 HGNC:3535 ENTREZ:2147 UNIPROT:P00734 GENECARDS:F2 REACTOME:66007 KEGG:2147 ATLASONC:GC_F2 WIKI:F2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Thrombin*"/> <bbox w="80.0" h="40.0" x="7384.0" y="164.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s45_wnc1_wnc1_sa38" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: coagulation factor II (thrombin) receptor HUGO:F2R HGNC:3537 ENTREZ:2149 UNIPROT:P25116 GENECARDS:F2R REACTOME:61310 KEGG:2149 ATLASONC:GC_F2R WIKI:F2R Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Par1' is a cleaved product of the PAR1 upon binding of the ligand References_end</body> </html> </notes> <label text="PAR1TRUNC*"/> <bbox w="80.0" h="40.0" x="7854.5" y="263.0"/> <glyph class="unit of information" id="_a2e6764a-4d08-4e25-96bc-21775a1bf5a2"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="7869.5" y="258.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s54_wnc1_wnc1_sa47" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re8:(MAP:survival) PMID:11694535 s_wnc1_re152(MAP:survival): Binding of beta-arrestin to PTEN increases the lipid phosphatase activity of PTEN which converts PIP3 to PIP2. Active ROCK stimulates this complex formation PMID:21642958 ROCK phosphorylates PTEN which is than activated. Activated PTEN reduces the concentration of PIP3 PMID:15793569 PMID:20008297 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: arrestin, beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 arrestin, beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="β-Arrestin*"/> <bbox w="80.0" h="40.0" x="7442.0" y="390.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s67_wnc1_wnc1_sa41" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re15:(MAP:survival) PMID:20223821 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="7772.75" y="585.0"/> <glyph class="state variable" id="_83bf5fe8-3737-4c24-af08-9f15955c4daa"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7847.75" y="580.0"/> </glyph> <glyph class="state variable" id="_82d2327a-4552-4f15-b291-b4f29ce8ce73"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7767.75" y="580.0"/> </glyph> <glyph class="state variable" id="_e4097a33-6555-4ab2-8767-74967cd03d23"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="7837.132" y="620.0"/> </glyph> <glyph class="state variable" id="_80765ae5-1dea-4679-b371-f13e8282f54d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7767.75" y="580.0"/> </glyph> <glyph class="state variable" id="_0b78341a-6ef7-4788-9471-a5b6b9c7b2f8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7847.75" y="580.0"/> </glyph> <glyph class="state variable" id="_2338d9e2-0779-41d3-bc1b-a4c2287f0927"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7844.8833" y="580.0"/> </glyph> <glyph class="state variable" id="_904b1ada-e111-4378-91ac-c2769ec0a98c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7847.75" y="620.0"/> </glyph> <glyph class="state variable" id="_8050df75-4c62-480f-8afa-ee3d1dedf3d7"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="7757.75" y="619.7223"/> </glyph> <glyph class="state variable" id="_e021d9e0-cd77-4371-92b8-d2e808004e03"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7767.75" y="620.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s71_wnc1_wnc1_sa11" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re17:(MAP:survival) PMID:21303971 s_wnc1_re3(MAP:survival): PMID:21506126 This phosphorylated of b-catenin bypasses the canonical wnt-MODULE and enters directly the nucleus where it is transcriptionally active PMID:16476742 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="8132.0" y="710.0"/> <glyph class="state variable" id="_3c2878d6-6478-4a70-ac68-3fe50572e249"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="8159.4043" y="745.0"/> </glyph> <glyph class="state variable" id="_e3e13f89-b7eb-4e52-ae3b-0e037dc17242"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="8198.882" y="745.0"/> </glyph> <glyph class="state variable" id="_3721893e-f0c7-45a9-858e-2eaee0b5521e"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="8199.5" y="705.2148"/> </glyph> <glyph class="state variable" id="_20efdda2-3e46-484d-b9d1-8d5ea04271be"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="8159.5317" y="705.0"/> </glyph> <glyph class="state variable" id="_f5663977-b6cc-41be-b443-7200785a9e81"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="8119.9927" y="705.0"/> </glyph> <glyph class="state variable" id="_bf83d959-f7bb-4728-aae0-9fd10f479609"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="8119.5" y="744.7223"/> </glyph> <glyph class="state variable" id="_f077ad19-d2be-4c09-97df-fe836209b5d7"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="8197.0" y="705.2148"/> </glyph> <glyph class="state variable" id="_34b8ec51-79a0-4f53-b3c5-ee87191ecaeb"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="8197.0" y="705.2148"/> </glyph> <glyph class="state variable" id="_6b5e1cd4-e825-4f35-84d2-f73d27010bc7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8127.0" y="725.0"/> </glyph> <glyph class="state variable" id="_3c82d50a-bca9-43ff-b758-760ad57e56a1"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="8117.4927" y="705.0"/> </glyph> <glyph class="state variable" id="_e1be1e00-f874-4920-ac46-8e455b3ed343"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="8197.0" y="705.2148"/> </glyph> <glyph class="state variable" id="_b12f61dd-9ab0-4710-bb6e-87b3578f9084"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8127.0" y="716.7157"/> </glyph> <glyph class="state variable" id="_66aec3f4-86ce-4f8c-b97a-9659dc472e76"> <state value="P" variable="S522"/> <bbox w="35.0" h="10.0" x="8194.5" y="705.2148"/> </glyph> <glyph class="state variable" id="_38ef7a5c-58a2-4464-8512-6f664798060f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8127.0" y="725.0"/> </glyph> <glyph class="state variable" id="_21c47ccd-5595-4c33-9912-c3a95bda0a76"> <state value="P" variable="S675"/> <bbox w="35.0" h="10.0" x="8193.882" y="745.0"/> </glyph> <glyph class="state variable" id="_eef3acd6-f807-4270-a995-cfc8bc8fa41c"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="8197.0" y="705.2148"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s72_wnc1_wnc1_sa7" compartmentRef="wnc1_wnc1_c2_wnc1_wnc1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re3(MAP:survival): PMID:21506126 This phosphorylated of b-catenin bypasses the canonical wnt-MODULE and enters directly the nucleus where it is transcriptionally active PMID:16476742 s_wnc1_re52(MAP:survival): This phosphorylated form of b-catenin facilitates interaction between b-catenin and CBP References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="8132.0" y="913.0979"/> <glyph class="state variable" id="_81fe0a0f-82f3-4128-a357-497a3b57c923"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="8159.4043" y="948.0979"/> </glyph> <glyph class="state variable" id="_ee4c72f0-12d5-4709-b287-5e538f9a6d26"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="8198.882" y="948.0979"/> </glyph> <glyph class="state variable" id="_5963ff39-fc1e-44ff-b5fa-86d82b1a3573"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="8199.5" y="908.3127"/> </glyph> <glyph class="state variable" id="_963f8b98-da0e-440e-9e77-d0d23371bb32"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="8159.5317" y="908.0979"/> </glyph> <glyph class="state variable" id="_08c6b96d-9b23-4916-b047-71ad4513c98c"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="8119.9927" y="908.0979"/> </glyph> <glyph class="state variable" id="_6125934d-501b-4e1b-8f95-67caafa3bc68"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="8119.5" y="947.8202"/> </glyph> <glyph class="state variable" id="_9409f5fd-3148-4089-954e-4737952931b9"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="8197.0" y="908.3127"/> </glyph> <glyph class="state variable" id="_0ef60091-d8f5-4da7-9b61-8afee4ef7214"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="8197.0" y="908.3127"/> </glyph> <glyph class="state variable" id="_a5365cea-e4be-4137-b647-1932da672197"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8127.0" y="928.0979"/> </glyph> <glyph class="state variable" id="_58300454-7432-4740-a282-cf4c8ba50f2b"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="8117.4927" y="908.0979"/> </glyph> <glyph class="state variable" id="_538ae60e-ffb6-4210-9ea7-5c06708a8b52"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="8197.0" y="908.3127"/> </glyph> <glyph class="state variable" id="_561700d4-1e9a-441b-8211-ea01a4f50aad"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8127.0" y="919.8136"/> </glyph> <glyph class="state variable" id="_933ece27-cb01-4e6d-8cca-bb644c9c9fc3"> <state value="P" variable="S522"/> <bbox w="35.0" h="10.0" x="8194.5" y="908.3127"/> </glyph> <glyph class="state variable" id="_a177d608-5783-45ed-b137-43276831f55f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8127.0" y="928.0979"/> </glyph> <glyph class="state variable" id="_b0c7c791-3ca6-4bbe-b008-16ced8ceb461"> <state value="P" variable="S675"/> <bbox w="35.0" h="10.0" x="8193.882" y="948.0979"/> </glyph> <glyph class="state variable" id="_e25f90fe-a5ae-420d-bce6-588640224d87"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="8197.0" y="908.3127"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s73_wnc1_wnc1_sa57" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re18:(MAP:survival) PMID:21693646 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: leucine-rich repeat containing G protein-coupled receptor 5 "G protein-coupled receptor 49", GPR49, GPR67, "leucine-rich repeat-containing G protein-coupled receptor 5" HUGO:LGR5 HGNC:4504 ENTREZ:8549 UNIPROT:O75473 GENECARDS:LGR5 KEGG:8549 ATLASONC:GC_LGR5 WIKI:LGR5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LGR5"/> <bbox w="80.0" h="50.0" x="8038.0" y="267.0"/> <glyph class="unit of information" id="_d33e647e-3596-450f-b27c-ed72038161ec"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8055.5" y="262.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s74_wnc1_wnc1_sa58"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re18:(MAP:survival) PMID:21693646 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: R-spondin 1 HUGO:RSPO1 HGNC:21679 ENTREZ:284654 UNIPROT:Q2MKA7 GENECARDS:RSPO1 KEGG:284654 ATLASONC:RSPO1ID44137ch1p34 WIKI:RSPO1 R-spondin 2 HUGO:RSPO2 HGNC:28583 ENTREZ:340419 UNIPROT:Q6UXX9 GENECARDS:RSPO2 KEGG:340419 ATLASONC:GC_RSPO2 WIKI:RSPO2 R-spondin 3 HUGO:RSPO3 HGNC:20866 ENTREZ:84870 UNIPROT:Q9BXY4 GENECARDS:RSPO3 KEGG:84870 ATLASONC:GC_RSPO3 WIKI:RSPO3 R-spondin 4 HUGO:RSPO4 HGNC:16175 ENTREZ:343637 UNIPROT:Q2I0M5 GENECARDS:RSPO4 KEGG:343637 WIKI:RSPO4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RSPO1-4*"/> <bbox w="40.0" h="30.0" x="8055.0" y="201.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s106_wnc1_wnc1_sa96" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re22(MAP:survival): Only the Galpha_q subunit can activate PLC-beta PMID:11395409 PMID:19359428 s_wnc1_re57(MAP:survival): PLC-beta_2 and 3 are activated by the beta-and gamma subunit of the G-protein class q PMID:20553968 s_wnc1_re58(MAP:survival): PMID:16402909 PMID:12657629 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phospholipase C, beta 1 (phosphoinositide-specific) HUGO:PLCB1 HGNC:15917 ENTREZ:23236 UNIPROT:Q9NQ66 GENECARDS:PLCB1 REACTOME:61694 KEGG:23236 ATLASONC:PLCB1ID41742ch20p12 WIKI:PLCB1 phospholipase C, beta 2 (phosphoinositide-specific) HUGO:PLCB2 HGNC:9055 ENTREZ:5330 UNIPROT:Q00722 GENECARDS:PLCB2 REACTOME:61696 ATLASONC:PLCB2ID41743ch15q15 WIKI:PLCB2 phospholipase C, beta 3 (phosphoinositide-specific) HUGO:PLCB3 HGNC:9056 ENTREZ:5331 UNIPROT:Q01970 GENECARDS:PLCB3 REACTOME:61748 ATLASONC:GC_PLCB3 WIKI:PLCB3 phospholipase C, beta 4 (phosphoinositide-specific) HUGO:PLCB4 HGNC:9059 ENTREZ:5332 UNIPROT:Q15147 GENECARDS:PLCB4 REACTOME:61698 KEGG:5332 ATLASONC:GC_PLCB4 WIKI:PLCB4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PLC-β*"/> <bbox w="80.0" h="40.0" x="7290.0" y="592.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s116_wnc1_wnc1_sa103" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: calcium/calmodulin-dependent protein kinase II alpha "calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha", CAMKA HUGO:CAMK2A HGNC:1460 ENTREZ:815 UNIPROT:Q9UQM7 GENECARDS:CAMK2A REACTOME:57903 KEGG:815 ATLASONC:GC_CAMK2A WIKI:CAMK2A calcium/calmodulin-dependent protein kinase II beta "calcium/calmodulin-dependent protein kinase (CaM kinase) II beta", CAMKB HUGO:CAMK2B HGNC:1461 ENTREZ:816 UNIPROT:Q13554 GENECARDS:CAMK2B REACTOME:57905 KEGG:816 ATLASONC:GC_CAMK2B WIKI:CAMK2B calcium/calmodulin-dependent protein kinase II delta HUGO:CAMK2D HGNC:1462 ENTREZ:817 UNIPROT:Q13557 GENECARDS:CAMK2D REACTOME:57907 KEGG:817 ATLASONC:GC_CAMK2D WIKI:CAMK2D calcium/calmodulin-dependent protein kinase II gamma HUGO:CAMK2G HGNC:1463 ENTREZ:818 UNIPROT:Q13555 GENECARDS:CAMK2G REACTOME:57909 KEGG:818 ATLASONC:GC_CAMK2G WIKI:CAMK2G calcium/calmodulin-dependent protein kinase II beta"calcium/calmodulin-dependent protein kinase (CaM kinase) II beta", CAMKB HUGO:CAMK2B HGNC:1461 ENTREZ:816 UNIPROT:Q13554 GENECARDS:CAMK2B REACTOME:57905 KEGG:816 ATLASONC:GC_CAMK2B WIKI:CAMK2B HUGO:CAMK2D HGNC:1462 ENTREZ:817 UNIPROT:Q13557 GENECARDS:CAMK2D REACTOME:57907 KEGG:817 ATLASONC:GC_CAMK2D WIKI:CAMK2D "calcium/calmodulin-dependent protein kinase (CaM kinase) II delta", CAMKD "calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma", CAMKG Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CAMK2*"/> <bbox w="80.0" h="40.0" x="7470.5" y="698.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s117_wnc1_wnc1_sa101" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re23:(MAP:survival) PMID:9859994 s_wnc1_re123(MAP:survival): Akt phosphorylates POSH in the Rac1 binding domain, preventing binding of Rac1 w/ POSH PMID:17535800 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:cellcycle / MODULE:CYCLIND MAP:cellcycle / MODULE:P21CIP MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:cellcycle / MODULE:CYCLIND MAP:cellcycle / MODULE:P21CIP MAP:cellcycle / MODULE:P27KIP MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end</body> </html> </notes> <label text="AKT1"/> <bbox w="80.0" h="40.0" x="7878.0" y="780.0"/> <glyph class="state variable" id="_6225aef1-1761-48c8-af1f-41e5ddf027bd"> <state value="" variable="T308"/> <bbox w="30.0" h="10.0" x="7863.0" y="778.77405"/> </glyph> <glyph class="state variable" id="_17aab5d4-196d-40aa-ab0c-c2f8c354f74b"> <state value="" variable="T450"/> <bbox w="30.0" h="10.0" x="7942.6333" y="775.0"/> </glyph> <glyph class="state variable" id="_a1d2f1c3-36c2-42cb-865d-c686eca8f20d"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="7943.0" y="814.1307"/> </glyph> <glyph class="state variable" id="_9201f870-aba3-403d-b741-0d0b1c1d9581"> <state value="" variable="S129"/> <bbox w="30.0" h="10.0" x="7863.0" y="811.1206"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s127_wnc1_wnc1_sa111" compartmentRef="wnc1_wnc1_c3_wnc1_wnc1_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re29:(MAP:survival) PMID:12747838 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: inositol 1,4,5-trisphosphate receptor, type 1 SCA15, SCA16, "spinocerebellar ataxia 15", "spinocerebellar ataxia 16" HUGO:ITPR1 HGNC:6180 ENTREZ:3708 UNIPROT:Q14643 GENECARDS:ITPR1 REACTOME:405731 KEGG:3708 ATLASONC:GC_ITPR1 WIKI:ITPR1 inositol 1,4,5-trisphosphate receptor, type 2 "inositol 1,4,5-triphosphate receptor, type 2" HUGO:ITPR2 HGNC:6181 ENTREZ:3709 UNIPROT:Q14571 GENECARDS:ITPR2 REACTOME:405722 KEGG:3709 ATLASONC:GC_ITPR2 WIKI:ITPR2 inositol 1,4,5-trisphosphate receptor, type "inositol 1,4,5-triphosphate receptor, type 3" HUGO:ITPR3 HGNC:6182 ENTREZ:3710 UNIPROT:Q14573 GENECARDS:ITPR3 REACTOME:57433 KEGG:3710 ATLASONC:GC_ITPR3 WIKI:ITPR3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="IP3R*"/> <bbox w="80.0" h="50.0" x="7311.0" y="929.0"/> <glyph class="unit of information" id="_ca32959c-7e32-45bf-b53b-b90f11946aae"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7328.5" y="924.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s152_wnc1_wnc1_sa126" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ADAM metallopeptidase domain 17 TACE, "tumor necrosis factor, alpha, converting enzyme" HUGO:ADAM17 HGNC:195 ENTREZ:6868 UNIPROT:P78536 GENECARDS:ADAM17 REACTOME:49678 KEGG:6868 ATLASONC:ADAM17ID572ch2p25 WIKI:ADAM17 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TACE*"/> <bbox w="80.0" h="40.0" x="7162.0" y="1130.0"/> <glyph class="state variable" id="_52595f5a-790a-4620-926f-e1fce69d1892"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7157.0" y="1165.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s154_wnc1_wnc1_sa127" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re35(MAP:survival): PMID:16054021 PMID:18372913 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ADAM metallopeptidase domain 17 TACE, "tumor necrosis factor, alpha, converting enzyme" HUGO:ADAM17 HGNC:195 ENTREZ:6868 UNIPROT:P78536 GENECARDS:ADAM17 REACTOME:49678 KEGG:6868 ATLASONC:ADAM17ID572ch2p25 WIKI:ADAM17 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TACE*"/> <bbox w="80.0" h="40.0" x="7162.0" y="1250.0"/> <glyph class="state variable" id="_feec5955-2b44-40a1-8373-6953645ce67d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7154.5" y="1285.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s155_wnc1_wnc1_sa128" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Ca2+/Wnt MODULE s_wnc1_re65(MAP:survival): Active PKC phosphorylates Dvl, just not enough to achieve the PS-form. PMID:12958364 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein kinase C alpha PKCA HUGO:PRKCA HGNC:9393 ENTREZ:5578 UNIPROT:P17252 protein kinase C beta PKCB PRKCB1 PRKCB2 "protein kinase C beta 1" HUGO:PRKCB HGNC:9395 ENTREZ:5579 UNIPROT:P05771 protein kinase C gamma PKCG SCA14 HUGO:PRKCG HGNC:9402 ENTREZ:5582 UNIPROT:P05129 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity. PMID:15567848 References_end Identifiers_begin: protein kinase C alpha PKCA HUGO:PRKCA HGNC:9393 ENTREZ:5578 UNIPROT:P17252 GENECARDS:PRKCA REACTOME:58197 KEGG:5578 ATLASONC:GC_PRKCA WIKI:PRKCA protein kinase C beta PKCB PRKCB1 PRKCB2 "protein kinase C beta 1" HUGO:PRKCB HGNC:9395 ENTREZ:5579 UNIPROT:P05771 GENECARDS:PRKCB REACTOME:58199 KEGG:5579 ATLASONC:GC_PRKCB WIKI:PRKCB protein kinase C gamma PKCG SCA14 HUGO:PRKCG HGNC:9402 ENTREZ:5582 UNIPROT:P05129 GENECARDS:PRKCG REACTOME:58205 KEGG:5582 ATLASONC:GC_PRKCG WIKI:PRKCG protein kinase C, delta HUGO:PRKCD HGNC:9399 ENTREZ:5580 UNIPROT:Q05655 GENECARDS:PRKCD REACTOME:58201 KEGG:5580 ATLASONC:PRKCDID42901ch3p21 WIKI:PRKCD protein kinase C, epsilon HUGO:PRKCE HGNC:9401 ENTREZ:5581 UNIPROT:Q02156 GENECARDS:PRKCE REACTOME:58203 KEGG:5581 ATLASONC:GC_PRKCE WIKI:PRKCE protein kinase C, eta HUGO:PRKCH HGNC:9403 ENTREZ:5583 UNIPROT:P24723 GENECARDS:PRKCH REACTOME:58209 KEGG:5583 ATLASONC:GC_PRKCH WIKI:PRKCH protein kinase C, iota HUGO:PRKCI HGNC:9404 ENTREZ:5584 UNIPROT:P41743 GENECARDS:PRKCI REACTOME:58207 KEGG:5584 ATLASONC:PRKCIID41857ch3q26 WIKI:PRKCI protein kinase C, theta HUGO:PRKCQ HGNC:9410 ENTREZ:5588 UNIPROT:Q04759 GENECARDS:PRKCQ REACTOME:58217 KEGG:5588 ATLASONC:GC_PRKCQ WIKI:PRKCQ Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity. PMID:15567848 PMID:11313945 PMID:11940581 Only PKC alpha and delta PMID:21386996 References_end Identifiers_begin: protein kinase C alpha PKCA HUGO:PRKCA HGNC:9393 ENTREZ:5578 UNIPROT:P17252 GENECARDS:PRKCA REACTOME:58197 KEGG:5578 ATLASONC:GC_PRKCA WIKI:PRKCA protein kinase C beta PKCB PRKCB1 PRKCB2 "protein kinase C beta 1" HUGO:PRKCB HGNC:9395 ENTREZ:5579 UNIPROT:P05771 GENECARDS:PRKCB REACTOME:58199 KEGG:5579 ATLASONC:GC_PRKCB WIKI:PRKCB protein kinase C gamma PKCG SCA14 HUGO:PRKCG HGNC:9402 ENTREZ:5582 UNIPROT:P05129 GENECARDS:PRKCG REACTOME:58205 KEGG:5582 ATLASONC:GC_PRKCG WIKI:PRKCG protein kinase C, delta HUGO:PRKCD HGNC:9399 ENTREZ:5580 UNIPROT:Q05655 GENECARDS:PRKCD REACTOME:58201 KEGG:5580 ATLASONC:PRKCDID42901ch3p21 WIKI:PRKCD protein kinase C, epsilon HUGO:PRKCE HGNC:9401 ENTREZ:5581 UNIPROT:Q02156 GENECARDS:PRKCE REACTOME:58203 KEGG:5581 ATLASONC:GC_PRKCE WIKI:PRKCE protein kinase C, eta HUGO:PRKCH HGNC:9403 ENTREZ:5583 UNIPROT:P24723 GENECARDS:PRKCH REACTOME:58209 KEGG:5583 ATLASONC:GC_PRKCH WIKI:PRKCH protein kinase C, iota HUGO:PRKCI HGNC:9404 ENTREZ:5584 UNIPROT:P41743 GENECARDS:PRKCI REACTOME:58207 KEGG:5584 ATLASONC:PRKCIID41857ch3q26 WIKI:PRKCI protein kinase C, theta HUGO:PRKCQ HGNC:9410 ENTREZ:5588 UNIPROT:Q04759 GENECARDS:PRKCQ REACTOME:58217 KEGG:5588 ATLASONC:GC_PRKCQ WIKI:PRKCQ Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity. PMID:15567848 PMID:11313945 PMID:11940581 Only PKC alpha and delta PMID:21386996 References_end</body> </html> </notes> <label text="PKC*"/> <clone/> <bbox w="80.0" h="40.0" x="7462.0" y="1190.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s155_wnc1_wnc1_sa129" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Ca2+/Wnt MODULE s_wnc1_re65(MAP:survival): Active PKC phosphorylates Dvl, just not enough to achieve the PS-form. PMID:12958364 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein kinase C alpha PKCA HUGO:PRKCA HGNC:9393 ENTREZ:5578 UNIPROT:P17252 protein kinase C beta PKCB PRKCB1 PRKCB2 "protein kinase C beta 1" HUGO:PRKCB HGNC:9395 ENTREZ:5579 UNIPROT:P05771 protein kinase C gamma PKCG SCA14 HUGO:PRKCG HGNC:9402 ENTREZ:5582 UNIPROT:P05129 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity. PMID:15567848 References_end Identifiers_begin: protein kinase C alpha PKCA HUGO:PRKCA HGNC:9393 ENTREZ:5578 UNIPROT:P17252 GENECARDS:PRKCA REACTOME:58197 KEGG:5578 ATLASONC:GC_PRKCA WIKI:PRKCA protein kinase C beta PKCB PRKCB1 PRKCB2 "protein kinase C beta 1" HUGO:PRKCB HGNC:9395 ENTREZ:5579 UNIPROT:P05771 GENECARDS:PRKCB REACTOME:58199 KEGG:5579 ATLASONC:GC_PRKCB WIKI:PRKCB protein kinase C gamma PKCG SCA14 HUGO:PRKCG HGNC:9402 ENTREZ:5582 UNIPROT:P05129 GENECARDS:PRKCG REACTOME:58205 KEGG:5582 ATLASONC:GC_PRKCG WIKI:PRKCG protein kinase C, delta HUGO:PRKCD HGNC:9399 ENTREZ:5580 UNIPROT:Q05655 GENECARDS:PRKCD REACTOME:58201 KEGG:5580 ATLASONC:PRKCDID42901ch3p21 WIKI:PRKCD protein kinase C, epsilon HUGO:PRKCE HGNC:9401 ENTREZ:5581 UNIPROT:Q02156 GENECARDS:PRKCE REACTOME:58203 KEGG:5581 ATLASONC:GC_PRKCE WIKI:PRKCE protein kinase C, eta HUGO:PRKCH HGNC:9403 ENTREZ:5583 UNIPROT:P24723 GENECARDS:PRKCH REACTOME:58209 KEGG:5583 ATLASONC:GC_PRKCH WIKI:PRKCH protein kinase C, iota HUGO:PRKCI HGNC:9404 ENTREZ:5584 UNIPROT:P41743 GENECARDS:PRKCI REACTOME:58207 KEGG:5584 ATLASONC:PRKCIID41857ch3q26 WIKI:PRKCI protein kinase C, theta HUGO:PRKCQ HGNC:9410 ENTREZ:5588 UNIPROT:Q04759 GENECARDS:PRKCQ REACTOME:58217 KEGG:5588 ATLASONC:GC_PRKCQ WIKI:PRKCQ Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity. PMID:15567848 PMID:11313945 PMID:11940581 Only PKC alpha and delta PMID:21386996 References_end Identifiers_begin: protein kinase C alpha PKCA HUGO:PRKCA HGNC:9393 ENTREZ:5578 UNIPROT:P17252 GENECARDS:PRKCA REACTOME:58197 KEGG:5578 ATLASONC:GC_PRKCA WIKI:PRKCA protein kinase C beta PKCB PRKCB1 PRKCB2 "protein kinase C beta 1" HUGO:PRKCB HGNC:9395 ENTREZ:5579 UNIPROT:P05771 GENECARDS:PRKCB REACTOME:58199 KEGG:5579 ATLASONC:GC_PRKCB WIKI:PRKCB protein kinase C gamma PKCG SCA14 HUGO:PRKCG HGNC:9402 ENTREZ:5582 UNIPROT:P05129 GENECARDS:PRKCG REACTOME:58205 KEGG:5582 ATLASONC:GC_PRKCG WIKI:PRKCG protein kinase C, delta HUGO:PRKCD HGNC:9399 ENTREZ:5580 UNIPROT:Q05655 GENECARDS:PRKCD REACTOME:58201 KEGG:5580 ATLASONC:PRKCDID42901ch3p21 WIKI:PRKCD protein kinase C, epsilon HUGO:PRKCE HGNC:9401 ENTREZ:5581 UNIPROT:Q02156 GENECARDS:PRKCE REACTOME:58203 KEGG:5581 ATLASONC:GC_PRKCE WIKI:PRKCE protein kinase C, eta HUGO:PRKCH HGNC:9403 ENTREZ:5583 UNIPROT:P24723 GENECARDS:PRKCH REACTOME:58209 KEGG:5583 ATLASONC:GC_PRKCH WIKI:PRKCH protein kinase C, iota HUGO:PRKCI HGNC:9404 ENTREZ:5584 UNIPROT:P41743 GENECARDS:PRKCI REACTOME:58207 KEGG:5584 ATLASONC:PRKCIID41857ch3q26 WIKI:PRKCI protein kinase C, theta HUGO:PRKCQ HGNC:9410 ENTREZ:5588 UNIPROT:Q04759 GENECARDS:PRKCQ REACTOME:58217 KEGG:5588 ATLASONC:GC_PRKCQ WIKI:PRKCQ Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity. PMID:15567848 PMID:11313945 PMID:11940581 Only PKC alpha and delta PMID:21386996 References_end</body> </html> </notes> <label text="PKC*"/> <clone/> <bbox w="80.0" h="40.0" x="7332.0" y="1190.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s157_wnc1_wnc1_sa130" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re35(MAP:survival): PMID:16054021 PMID:18372913 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heparin-binding EGF-like growth factor "diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor)", DTR, DTS, HEGFL HUGO:HBEGF HGNC:3059 ENTREZ:1839 UNIPROT:Q99075 GENECARDS:HBEGF REACTOME:56374 KEGG:1839 ATLASONC:GC_HBEGF WIKI:HBEGF Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: pro-protein References_end</body> </html> </notes> <label text="Pro HB-EGF*"/> <bbox w="80.0" h="40.0" x="7162.0" y="1322.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s158_wnc1_wnc1_sa131"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re35(MAP:survival): PMID:16054021 PMID:18372913 s_wnc1_re37(MAP:survival): PAR1 activates EGFR PMID:16525676 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: @heparin-binding EGF-like growth factor "diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor)", DTR, DTS, HEGFL HUGO:HBEGF HGNC:3059 ENTREZ:1839 UNIPROT:Q99075 GENECARDS:HBEGF REACTOME:56374 KEGG:1839 ATLASONC:GC_HBEGF WIKI:HBEGF Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HB-EGF*"/> <bbox w="80.0" h="40.0" x="7042.0" y="1322.0"/> <glyph class="unit of information" id="_d5082453-7b9c-4dea-b5a2-787301e1fd2a"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="7057.0" y="1317.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s159_wnc1_wnc1_sa132" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re37(MAP:survival): PMID:18372913 PAR1 activates EGFR PMID:16525676 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ HUGO:EGFR MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:20430953 All EGF family members bind to a group of four receptor tyrosine kinases, namely ErbB-1/EGFR through -4 (also called HER1???4). Like other tyrosine kinases, each ErbB molecule comprises an extracellular domain to allow ligand binding, a single transmembrane part, and an intracellular protein tyrosine kinase domain. It is important noting that not all ErbB receptors act autonomously: ErbB-2 (also called HER2 and Neu) binds no known EGF-like ligand (56), and ErbB-3 shows no tyrosine kinase activity (40). PMID:28513565 Epidermal growth factor receptor (EGFR) signaling pathways leading to G1/S cell cycle progression activated by EGF activation. Depicted are the RAS-RAF-MEK-ERK MAPK and PI3K-AKT-mTOR pathways. Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)", ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="EGFR"/> <bbox w="80.0" h="50.0" x="7162.0" y="1375.0"/> <glyph class="unit of information" id="_7ce0ceb1-1820-4065-abad-596b74f6b4fa"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7179.5" y="1370.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s160_wnc1_wnc1_sa133" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re37(MAP:survival): PMID:18372913 PAR1 activates EGFR PMID:16525676 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) NGL, "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:ECM MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HER2*"/> <bbox w="80.0" h="50.0" x="7162.0" y="1445.0"/> <glyph class="unit of information" id="_5c54c748-a6eb-45f6-a80c-d40c3fad0277"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7179.5" y="1440.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s165_wnc1_wnc1_sa143" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LRP6"/> <bbox w="80.0" h="50.0" x="9533.0" y="390.0"/> <glyph class="state variable" id="_5d052245-51e2-4391-abd4-c7443f30db52"> <state value="" variable="T1572"/> <bbox w="35.0" h="10.0" x="9515.5" y="409.96017"/> </glyph> <glyph class="state variable" id="_8dc259e5-dba6-4224-9154-56ee6b07c4c0"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="9555.532" y="385.0"/> </glyph> <glyph class="state variable" id="_9fd68349-03c7-4cbf-9162-18fa6b129750"> <state value="" variable="S1544"/> <bbox w="35.0" h="10.0" x="9595.5" y="385.26846"/> </glyph> <glyph class="state variable" id="_a1f7835c-d959-4e8e-b96d-66d9932be01d"> <state value="" variable="T1548"/> <bbox w="35.0" h="10.0" x="9595.5" y="423.43716"/> </glyph> <glyph class="state variable" id="_597e3893-7143-4ea3-83ea-8e4b66a91843"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="9595.5" y="385.26846"/> </glyph> <glyph class="state variable" id="_7f9c646b-9268-4ec4-83eb-192fef643ccd"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="9515.992" y="385.0"/> </glyph> <glyph class="unit of information" id="_f47e66d9-0d48-42e1-8bb5-bbe9a1f7acfc"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9550.5" y="385.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s206_wnc1_wnc1_sa165" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re40:(MAP:survival) PMID:9228084 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: adenylate cyclase 1 (brain) HUGO:ADCY1 HGNC:232 ENTREZ:107 UNIPROT:Q08828 GENECARDS:ADCY1 REACTOME:53232 KEGG:107 WIKI:ADCY1 adenylate cyclase 2 (brain) HUGO:ADCY2 HGNC:233 ENTREZ:108 UNIPROT:Q08462 GENECARDS:ADCY2 REACTOME:53234 KEGG:108 ATLASONC:GC_ADCY2 WIKI:ADCY2 adenylate cyclase 3 HUGO:ADCY3 HGNC:234 ENTREZ:109 UNIPROT:O60266 GENECARDS:ADCY3 REACTOME:53236 KEGG:114 WIKI:ADCY3 adenylate cyclase 4 HUGO:ADCY4 HGNC:235 ENTREZ:196883 UNIPROT:Q8NFM4 GENECARDS:ADCY4 REACTOME:53238 KEGG:196883 WIKI:ADCY4 adenylate cyclase 5 HUGO:ADCY5 HGNC:236 ENTREZ:111 UNIPROT:O95622 GENECARDS:ADCY5 REACTOME:53240 KEGG:111 WIKI:ADCY5 adenylate cyclase 6 HUGO:ADCY6 HGNC:237 ENTREZ:112 UNIPROT:O43306 GENECARDS:ADCY6 REACTOME:53242 KEGG:112 ATLASONC:GC_ADCY6 WIKI:ADCY6 adenylate cyclase 7 HUGO:ADCY7 HGNC:238 ENTREZ:113 UNIPROT:P51828 GENECARDS:ADCY7 REACTOME:53244 KEGG:113 ATLASONC:GC_ADCY7 WIKI:ADCY7 adenylate cyclase 8 HUGO:ADCY8 HGNC:239 ENTREZ:114 UNIPROT:P40145 GENECARDS:ADCY8 REACTOME:53246 KEGG:114 ATLASONC:GC_ADCY8 WIKI:ADCY8 adenylate cyclase 9 HUGO:ADCY9 HGNC:240 ENTREZ:115 UNIPROT:O60503 GENECARDS:ADCY9 REACTOME:53248 KEGG:115 WIKI:ADCY9 adenylate cyclase 10 HUGO:ADCY10 HGNC:21285 ENTREZ:55811 UNIPROT:Q96PN6 GENECARDS:ADCY10 KEGG:55811 ATLASONC:GC_ADCY10 WIKI:ADCY10 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Adenylyl_cyclase*"/> <bbox w="80.0" h="40.0" x="9232.0" y="640.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s225_wnc1_wnc1_sa177" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="8942.0" y="570.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s232_wnc1_wnc1_sa184"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re47:(MAP:survival) PMID:21237163 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: connective tissue growth factor HUGO:CTGF HGNC:2500 ENTREZ:1490 UNIPROT:P29279 GENECARDS:CTGF REACTOME:53030 KEGG:1490 ATLASONC:CTGFID40192ch6q23 WIKI:CTGF Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CCN2*"/> <bbox w="35.0" h="30.0" x="9567.5" y="742.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s239_wnc1_wnc1_sa188"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: ClasII: Wnt4,-5a,-5b, and -11 Apperently wnt-3a is also able to induce the PCP MODULE PMID:18187455 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="9611.0" y="1004.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s269_wnc1_wnc1_sa209" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re51(MAP:survival): PMID:20628572 RGS3 and RGS14 are GTP-ase activating proteins for Gi_alpha and Gq_alpha. PMID:10999941 PMID:12534294 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: HUGO:RGS3 HGNC:9999 ENTREZ:5998 UNIPROT:P49796 GENECARDS:RGS3 KEGG:5998 ATLASONC:GC_RGS3 WIKI:RGS3 regulator of G-protein signaling 4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12011974 References_end</body> </html> </notes> <label text="RGS3"/> <bbox w="80.0" h="40.0" x="9061.0" y="1091.0"/> <glyph class="state variable" id="_0e1cc9ea-6ce3-4208-8975-8900d8d3858f"> <state value="" variable="S264"/> <bbox w="30.0" h="10.0" x="9126.0" y="1097.7789"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s271_wnc1_wnc1_sa210" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re56(MAP:survival): PMID:20347994 PMID:10862767 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: HUGO:RGS3 HGNC:9999 ENTREZ:5998 UNIPROT:P49796 GENECARDS:RGS3 KEGG:5998 ATLASONC:GC_RGS3 WIKI:RGS3 regulator of G-protein signaling 4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12011974 References_end</body> </html> </notes> <label text="RGS3"/> <bbox w="80.0" h="40.0" x="9061.0" y="1000.0"/> <glyph class="state variable" id="_0d1844c2-3fec-4f44-b772-6b3b3b333a08"> <state value="P" variable="S264"/> <bbox w="35.0" h="10.0" x="9123.5" y="1006.77893"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s272_wnc1_wnc1_sa211" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="8942.0" y="920.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s291_wnc1_wnc1_sa224" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ROR2"/> <bbox w="80.0" h="50.0" x="9531.0" y="1398.0"/> <glyph class="state variable" id="_102f6975-510f-4c6b-b3d4-be599353bcd1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9566.0" y="1443.0"/> </glyph> <glyph class="state variable" id="_35fbe08e-68e1-440b-8bae-3d74ec74d60c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9526.0" y="1393.0"/> </glyph> <glyph class="state variable" id="_3e4489af-4dad-4049-915b-0da0f528a858"> <state value="" variable="S864"/> <bbox w="30.0" h="10.0" x="9596.0" y="1393.2684"/> </glyph> <glyph class="state variable" id="_66c26e6e-3284-4c54-a473-a43a73b2ff22"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9606.0" y="1443.0"/> </glyph> <glyph class="unit of information" id="_b8b5d01e-1413-4294-99ce-196a1b3fe822"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9548.5" y="1393.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s292_wnc1_wnc1_sa225" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re62(MAP:survival): Cthrc1 enhances formation of Wnt-Fzl-Ror2 complex PMID:12839624 PMID:18606138 Syndecan-4 binds to Fzl, Dvl and is required for PCP MODULE. PMID:16604063 PMID:21397842 Vangl-2 forms complex upon binding with Wnt-5 PMID:21316585 ROR2 is associated with Wnt, Fzl and CK1_epsilon PMID:20215527 PPR binds to Fzl in both canonical and non-canonical MODULE PMID:20093472 PMID:21380625 PMID:20579883 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: collagen triple helix repeat containing 1 HUGO:CTHRC1 HGNC:18831 ENTREZ:115908 UNIPROT:Q96CG8 GENECARDS:CTHRC1 ATLASONC:CTHRC1ID40193ch8q22 WIKI:CTHRC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTHRC1"/> <bbox w="50.0" h="20.0" x="9548.0" y="1477.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s321_wnc1_wnc1_sa251" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re46(MAP:survival): Upon Ca2+ activation the NRON-NFAT complex dissociates. PMID:21709260 s_wnc1_re62(MAP:survival): Cthrc1 enhances formation of Wnt-Fzl-Ror2 complex PMID:12839624 PMID:18606138 Syndecan-4 binds to Fzl, Dvl and is required for PCP MODULE. PMID:16604063 PMID:21397842 Vangl-2 forms complex upon binding with Wnt-5 PMID:21316585 ROR2 is associated with Wnt, Fzl and CK1_epsilon PMID:20215527 PPR binds to Fzl in both canonical and non-canonical MODULE PMID:20093472 PMID:21380625 PMID:20579883 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="9270.5" y="1432.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s331_wnc1_wnc1_sa257" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re65(MAP:survival): Active PKC phosphorylates Dvl, just not enough to achieve the PS-form. PMID:12958364 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="9178.0" y="1936.0"/> <glyph class="state variable" id="_6cd1e89c-4428-46d7-9ed6-fcafee9720c0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9253.0" y="1931.0"/> </glyph> <glyph class="state variable" id="_3581e291-fdd9-479d-91f3-13319bfb0d39"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9173.0" y="1931.0"/> </glyph> <glyph class="state variable" id="_3751da45-5c26-40c0-9335-1828d75fff54"> <state value="P" variable="S139"/> <bbox w="35.0" h="10.0" x="9239.882" y="1971.0"/> </glyph> <glyph class="state variable" id="_3d63448e-347a-419c-a6e7-8df8bd1e34b3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9173.0" y="1931.0"/> </glyph> <glyph class="state variable" id="_7541c9fd-b6d2-41ce-95c5-85c81130b1d6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9253.0" y="1931.0"/> </glyph> <glyph class="state variable" id="_be084f0a-b261-4e81-aca3-9c85329a0fb0"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9250.134" y="1931.0"/> </glyph> <glyph class="state variable" id="_19f3938a-f383-4b0b-afd4-e2bf3b27a8a6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9253.0" y="1971.0"/> </glyph> <glyph class="state variable" id="_e462a21f-110d-4bc5-bcf0-12c0d3c086a3"> <state value="P" variable="S142"/> <bbox w="35.0" h="10.0" x="9160.5" y="1970.7223"/> </glyph> <glyph class="state variable" id="_879c3e74-2064-4316-93ad-eb7ad2b02dc7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9173.0" y="1971.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s380_wnc1_wnc1_sa291" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re62(MAP:survival): Cthrc1 enhances formation of Wnt-Fzl-Ror2 complex PMID:12839624 PMID:18606138 Syndecan-4 binds to Fzl, Dvl and is required for PCP MODULE. PMID:16604063 PMID:21397842 Vangl-2 forms complex upon binding with Wnt-5 PMID:21316585 ROR2 is associated with Wnt, Fzl and CK1_epsilon PMID:20215527 PPR binds to Fzl in both canonical and non-canonical MODULE PMID:20093472 PMID:21380625 PMID:20579883 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end</body> </html> </notes> <label text="SYN4*"/> <bbox w="80.0" h="50.0" x="9529.0" y="1335.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s386_wnc1_wnc1_sa297" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="9045.0" y="1935.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s409_wnc1_wnc1_sa317" compartmentRef="wnc1_wnc1_c3_wnc1_wnc1_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re73:(MAP:survival) PMID:19966784 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: VANGL planar cell polarity protein 2 "vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila)", "vang-like 2 (van gogh, Drosophila)" HUGO:VANGL2 HGNC:15511 ENTREZ:57216 UNIPROT:Q9ULK5 GENECARDS:VANGL2 KEGG:57216 ATLASONC:GC_VANGL2 WIKI:VANGL2 VANGL planar cell polarity protein 1 "vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila)", "vang-like 1 (van gogh, Drosophila)" HUGO:VANGL1 HGNC:15512 ENTREZ:81839 UNIPROT:Q8TAA9 GENECARDS:VANGL1 KEGG:81839 ATLASONC:GC_VANGL1 WIKI:VANGL1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="VANGL*"/> <bbox w="80.0" h="50.0" x="8106.5" y="1176.0"/> <glyph class="state variable" id="_d2c3cbf1-dfa7-4b6d-95c0-f1b7177c874c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8181.5" y="1171.0"/> </glyph> <glyph class="state variable" id="_c8265b14-c4d1-49b3-bfed-8a2829aaf866"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8181.5" y="1196.0"/> </glyph> <glyph class="state variable" id="_7a5c0c6a-63f2-4c5d-ad1c-e042b75ac503"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8101.5" y="1171.0"/> </glyph> <glyph class="state variable" id="_576e990e-f161-4ffe-a4ab-01bf3fca51dd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8101.5" y="1196.0"/> </glyph> <glyph class="unit of information" id="_5ae1b686-e432-4ebe-a73d-9adc7bb5d4ca"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8124.0" y="1171.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s410_wnc1_wnc1_sa318" compartmentRef="wnc1_wnc1_c5_wnc1_wnc1_ca6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re73:(MAP:survival) PMID:19966784 s_wnc1_re91(MAP:survival): PMID:19701191 Dac1 primarly functions in beta-catenin-independent MODULEs PMID:21718540 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: VANGL planar cell polarity protein 2 "vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila)", "vang-like 2 (van gogh, Drosophila)" HUGO:VANGL2 HGNC:15511 ENTREZ:57216 UNIPROT:Q9ULK5 GENECARDS:VANGL2 KEGG:57216 ATLASONC:GC_VANGL2 WIKI:VANGL2 VANGL planar cell polarity protein 1 "vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila)", "vang-like 1 (van gogh, Drosophila)" HUGO:VANGL1 HGNC:15512 ENTREZ:81839 UNIPROT:Q8TAA9 GENECARDS:VANGL1 KEGG:81839 ATLASONC:GC_VANGL1 WIKI:VANGL1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="VANGL*"/> <bbox w="80.0" h="50.0" x="8423.5" y="1176.0"/> <glyph class="state variable" id="_8583919c-f2e8-40ba-b591-b6a066a817da"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8498.5" y="1171.0"/> </glyph> <glyph class="state variable" id="_8d38b5d8-539e-4fc5-b619-15809970f5eb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8498.5" y="1196.0"/> </glyph> <glyph class="state variable" id="_c44e3a81-2990-45dc-aacd-0a3291638e7d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8418.5" y="1171.0"/> </glyph> <glyph class="state variable" id="_2ba1d615-4983-4783-a154-69144b424b6a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8418.5" y="1196.0"/> </glyph> <glyph class="unit of information" id="_0247cfa6-cf9e-41ee-a860-674ba0308019"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8441.0" y="1171.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s411_wnc1_wnc1_sa319" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re73:(MAP:survival) PMID:19966784 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: SEC24 family, member B (S. cerevisiae) "SEC24 (S. cerevisiae) related gene family, member B", "SEC24 related gene family, member B (S. cerevisiae)" HUGO:SEC24B HGNC:10704 ENTREZ:10427 UNIPROT:O95487 GENECARDS:SEC24B REACTOME:64014 KEGG:10427 WIKI:SEC24B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="SEC24B"/> <bbox w="80.0" h="40.0" x="8264.0" y="1262.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s469_wnc1_wnc1_sa349" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re77(MAP:survival): CK1 delta phosphorylates residues in cluster I: S84, S82, S79, T71 and in cluster II: S5, S8, S11, S14, S17, S20. Note: Experiments were performed in Xenopus PMID:21316585 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CK1δ*"/> <bbox w="80.0" h="40.0" x="7348.0" y="2356.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s472_wnc1_wnc1_sa351" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re78:(MAP:survival) PMID:22037766 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: prickle homolog 1 (Drosophila) "prickle-like 1 (Drosophila)" HUGO:PRICKLE1 HGNC:17019 ENTREZ:144165 UNIPROT:Q96MT3 GENECARDS:PRICKLE1 KEGG:144165 ATLASONC:GC_PRICKLE1 WIKI:PRICKLE1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Prickle is actually associated with membrane References_end</body> </html> </notes> <label text="PRICKLE1"/> <bbox w="80.0" h="40.0" x="9003.25" y="1374.0"/> <glyph class="state variable" id="_b12a5905-b867-45ab-81d8-d01fcf24e0df"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9078.25" y="1369.0"/> </glyph> <glyph class="state variable" id="_4592c5d2-752b-48e9-b018-a1b0a14d431d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8998.25" y="1369.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s473_wnc1_wnc1_sa352" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re78:(MAP:survival) PMID:22037766 s_wnc1_re85(MAP:survival): Prickle interacts physically with Vangl PMID:22037766 PMID:12941693 Par6 is constitutively associated with Dvl PMID:19379695 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: prickle homolog 1 (Drosophila) "prickle-like 1 (Drosophila)" HUGO:PRICKLE1 HGNC:17019 ENTREZ:144165 UNIPROT:Q96MT3 GENECARDS:PRICKLE1 KEGG:144165 ATLASONC:GC_PRICKLE1 WIKI:PRICKLE1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Prickle is actually associated with membrane References_end</body> </html> </notes> <label text="PRICKLE1"/> <bbox w="80.0" h="40.0" x="9005.25" y="1483.0"/> <glyph class="state variable" id="_0044e761-71d3-4cb9-b70b-92f73d294ab3"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9077.75" y="1478.0"/> </glyph> <glyph class="state variable" id="_e1a4d137-18a1-4750-8bf5-42d630b6e5bf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9000.25" y="1478.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s474_wnc1_wnc1_sa353" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re78:(MAP:survival) PMID:22037766 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: misshapen-like kinase 1 "misshapen-like kinase 1 (zebrafish)" HUGO:MINK1 HGNC:17565 ENTREZ:50488 UNIPROT:Q8N4C8 GENECARDS:MINK1 KEGG:50488 WIKI:MINK1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MINK1"/> <bbox w="80.0" h="40.0" x="9125.0" y="1429.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s585_wnc1_wnc1_sa412" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re111(MAP:survival): Rspo is required for clathrin-mediated endocytosis PMID:21397842 It has been shown that Dvl polymers are not associated with vesicles, therefore endocytosis of the complex is likely to be after Dvl polymerisation. PMID:16263762 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: SMAD specific E3 ubiquitin protein ligase 1 HUGO:SMURF1 HGNC:16807 ENTREZ:57154 UNIPROT:Q9HCE7 GENECARDS:SMURF1 REACTOME:414424 ATLASONC:GC_SMURF1 WIKI:SMURF1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="SMURF1"/> <clone/> <bbox w="80.0" h="40.0" x="9068.5" y="2276.5"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s585_wnc1_wnc1_sa459" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re111(MAP:survival): Rspo is required for clathrin-mediated endocytosis PMID:21397842 It has been shown that Dvl polymers are not associated with vesicles, therefore endocytosis of the complex is likely to be after Dvl polymerisation. PMID:16263762 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: SMAD specific E3 ubiquitin protein ligase 1 HUGO:SMURF1 HGNC:16807 ENTREZ:57154 UNIPROT:Q9HCE7 GENECARDS:SMURF1 REACTOME:414424 ATLASONC:GC_SMURF1 WIKI:SMURF1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="SMURF1"/> <clone/> <bbox w="80.0" h="40.0" x="8964.5" y="2489.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s717_wnc1_wnc1_sa460" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re111(MAP:survival): Rspo is required for clathrin-mediated endocytosis PMID:21397842 It has been shown that Dvl polymers are not associated with vesicles, therefore endocytosis of the complex is likely to be after Dvl polymerisation. PMID:16263762 s_wnc1_re90(MAP:survival): PMID:19379695 PMID:20930545 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: prickle homolog 1 (Drosophila) "prickle-like 1 (Drosophila)" HUGO:PRICKLE1 HGNC:17019 ENTREZ:144165 UNIPROT:Q96MT3 GENECARDS:PRICKLE1 KEGG:144165 ATLASONC:GC_PRICKLE1 WIKI:PRICKLE1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Prickle is actually associated with membrane References_end</body> </html> </notes> <label text="PRICKLE1"/> <bbox w="80.0" h="40.0" x="8557.5" y="2198.0"/> <glyph class="state variable" id="_37e3d013-f98a-46a2-9912-512e8eb5801c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8630.0" y="2193.0"/> </glyph> <glyph class="state variable" id="_ba7d30b5-bbfe-4f77-8c0f-fbbb42c16cb0"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="8547.5" y="2193.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s718_wnc1_wnc1_sa461" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re85(MAP:survival): Prickle interacts physically with Vangl PMID:22037766 PMID:12941693 Par6 is constitutively associated with Dvl PMID:19379695 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: par-6 partitioning defective 6 homolog alpha (C. elegans) "par-6 (partitioning defective 6, C.elegans) homolog alpha" HUGO:PARD6A HGNC:15943 ENTREZ:50855 UNIPROT:Q9NPB6 GENECARDS:PARD6A REACTOME:97684 KEGG:50855 ATLASONC:GC_PARD6A WIKI:PARD6A Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PAR6*"/> <bbox w="80.0" h="40.0" x="9020.0" y="1211.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s719_wnc1_wnc1_sa462" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dapper antagonist of beta-catenin homolog 1 (Xenopus laevis) "dapper homolog 1 antagonist of beta-catenin (xenopus)" HUGO:DACT1 HGNC:17748 ENTREZ:51339 UNIPROT:Q9NYF0 GENECARDS:DACT1 KEGG:51339 ATLASONC:GC_DACT1 WIKI:DACT1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: dapper antagonist of beta-catenin homolog 1 (Xenopus laevis) "dapper homolog 1 antagonist of beta-catenin (xenopus)" HUGO:DACT1 HGNC:17748 ENTREZ:51339 UNIPROT:Q9NYF0 GENECARDS:DACT1 KEGG:51339 ATLASONC:GC_DACT1 WIKI:DACT1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="DACT1"/> <bbox w="80.0" h="40.0" x="8875.0" y="1101.0"/> <glyph class="state variable" id="_df513835-8226-4b39-b8fd-0d503a1fd230"> <state value="" variable="S237"/> <bbox w="30.0" h="10.0" x="8860.492" y="1096.0"/> </glyph> <glyph class="state variable" id="_f2e62aad-bfec-43a6-8903-4836ac42ae24"> <state value="" variable="S827"/> <bbox w="30.0" h="10.0" x="8939.382" y="1136.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s724_wnc1_wnc1_sa465" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re93:(MAP:survival) PMID:21262972 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dapper antagonist of beta-catenin homolog 1 (Xenopus laevis) "dapper homolog 1 antagonist of beta-catenin (xenopus)" HUGO:DACT1 HGNC:17748 ENTREZ:51339 UNIPROT:Q9NYF0 GENECARDS:DACT1 KEGG:51339 ATLASONC:GC_DACT1 WIKI:DACT1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: dapper antagonist of beta-catenin homolog 1 (Xenopus laevis) "dapper homolog 1 antagonist of beta-catenin (xenopus)" HUGO:DACT1 HGNC:17748 ENTREZ:51339 UNIPROT:Q9NYF0 GENECARDS:DACT1 KEGG:51339 ATLASONC:GC_DACT1 WIKI:DACT1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="DACT1"/> <bbox w="80.0" h="40.0" x="8739.5" y="1201.0"/> <glyph class="state variable" id="_195bb5d8-b9fe-45cd-bb4a-b6a9b9d6cf64"> <state value="P" variable="S237"/> <bbox w="35.0" h="10.0" x="8722.492" y="1196.0"/> </glyph> <glyph class="state variable" id="_4f376d5e-20d3-4477-a2f5-c09391be46b7"> <state value="P" variable="S827"/> <bbox w="35.0" h="10.0" x="8801.382" y="1236.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s828_wnc1_wnc1_sa358" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="8691.75" y="1956.5"/> <glyph class="state variable" id="_7e5cfdd3-4b80-4cd9-8589-cdce2ed39ae1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8766.75" y="1951.5"/> </glyph> <glyph class="state variable" id="_9fc1a065-d1a4-4983-96ad-2bee001f6f48"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8686.75" y="1951.5"/> </glyph> <glyph class="state variable" id="_0a8536af-5880-4f8b-ab32-4fb6c032b9b4"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="8756.132" y="1991.5"/> </glyph> <glyph class="state variable" id="_5b7c0696-a062-421a-849b-5d7edfd1cf2d"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="8681.75" y="1951.5"/> </glyph> <glyph class="state variable" id="_465f8bd0-220d-442f-9ccc-d11f9b9c6178"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8766.75" y="1951.5"/> </glyph> <glyph class="state variable" id="_b3909827-a87b-4ebe-aeb5-7912202471f9"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8763.884" y="1951.5"/> </glyph> <glyph class="state variable" id="_d411a41a-0530-4608-882b-a3406d834053"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8766.75" y="1991.5"/> </glyph> <glyph class="state variable" id="_0f1434e9-8608-42b1-8acc-ef44f4669b5f"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="8676.75" y="1991.2223"/> </glyph> <glyph class="state variable" id="_0bd17097-dab5-481e-bb01-f7ba030c921f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8686.75" y="1991.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s865_wnc1_wnc1_sa176" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re45:(MAP:survival) PMID:21406690 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LRP6"/> <clone/> <bbox w="80.0" h="50.0" x="9534.0" y="468.0"/> <glyph class="state variable" id="_f437869b-05ad-42b4-a250-85e7920077a4"> <state value="" variable="T1572"/> <bbox w="35.0" h="10.0" x="9516.5" y="487.96017"/> </glyph> <glyph class="state variable" id="_e875c3c2-c87a-4603-ae81-71cafea99346"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="9556.532" y="463.0"/> </glyph> <glyph class="state variable" id="_1020a81d-a13f-4e78-a11f-a12ff09e0ea8"> <state value="P" variable="S1544"/> <bbox w="40.0" h="10.0" x="9594.0" y="463.26846"/> </glyph> <glyph class="state variable" id="_87c16f58-79a2-484e-bfd0-63ffa44d2c5f"> <state value="P" variable="T1548"/> <bbox w="40.0" h="10.0" x="9594.0" y="501.43716"/> </glyph> <glyph class="state variable" id="_c3f955ce-2374-4b27-ac50-85660bc86923"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="9596.5" y="463.26846"/> </glyph> <glyph class="state variable" id="_fb1e2e1c-ef19-4564-9e1c-11ff2f31118f"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="9516.992" y="463.0"/> </glyph> <glyph class="unit of information" id="_a46310e0-e3ac-450f-a04d-dfdb54063b13"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9551.5" y="463.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s865_wnc1_wnc1_sa181" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re45:(MAP:survival) PMID:21406690 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LRP6"/> <clone/> <bbox w="80.0" h="50.0" x="9520.0" y="694.0"/> <glyph class="state variable" id="_0dccbc94-32de-431a-b484-007e43d50b10"> <state value="" variable="T1572"/> <bbox w="35.0" h="10.0" x="9502.5" y="713.9602"/> </glyph> <glyph class="state variable" id="_78acfec8-3ae7-4268-84a2-823b5f7496e9"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="9542.532" y="689.0"/> </glyph> <glyph class="state variable" id="_bb154713-5a02-407a-acdb-0f080116d16c"> <state value="P" variable="S1544"/> <bbox w="40.0" h="10.0" x="9580.0" y="689.26843"/> </glyph> <glyph class="state variable" id="_79b93798-2c5e-4ce6-b02b-a86d3359815e"> <state value="P" variable="T1548"/> <bbox w="40.0" h="10.0" x="9580.0" y="727.4372"/> </glyph> <glyph class="state variable" id="_d5dcb017-9a7a-4da7-925b-a03408cc50a0"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="9582.5" y="689.26843"/> </glyph> <glyph class="state variable" id="_f854ede7-4821-472c-94a0-483f7019e6bf"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="9502.992" y="689.0"/> </glyph> <glyph class="unit of information" id="_736a6bd0-91fd-4bff-b7b2-2120a81aefd9"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9537.5" y="689.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s866_wnc1_wnc1_sa161" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: adenylate cyclase 1 (brain) HUGO:ADCY1 HGNC:232 ENTREZ:107 UNIPROT:Q08828 GENECARDS:ADCY1 REACTOME:53232 KEGG:107 WIKI:ADCY1 adenylate cyclase 2 (brain) HUGO:ADCY2 HGNC:233 ENTREZ:108 UNIPROT:Q08462 GENECARDS:ADCY2 REACTOME:53234 KEGG:108 ATLASONC:GC_ADCY2 WIKI:ADCY2 adenylate cyclase 3 HUGO:ADCY3 HGNC:234 ENTREZ:109 UNIPROT:O60266 GENECARDS:ADCY3 REACTOME:53236 KEGG:114 WIKI:ADCY3 adenylate cyclase 4 HUGO:ADCY4 HGNC:235 ENTREZ:196883 UNIPROT:Q8NFM4 GENECARDS:ADCY4 REACTOME:53238 KEGG:196883 WIKI:ADCY4 adenylate cyclase 5 HUGO:ADCY5 HGNC:236 ENTREZ:111 UNIPROT:O95622 GENECARDS:ADCY5 REACTOME:53240 KEGG:111 WIKI:ADCY5 adenylate cyclase 6 HUGO:ADCY6 HGNC:237 ENTREZ:112 UNIPROT:O43306 GENECARDS:ADCY6 REACTOME:53242 KEGG:112 ATLASONC:GC_ADCY6 WIKI:ADCY6 adenylate cyclase 7 HUGO:ADCY7 HGNC:238 ENTREZ:113 UNIPROT:P51828 GENECARDS:ADCY7 REACTOME:53244 KEGG:113 ATLASONC:GC_ADCY7 WIKI:ADCY7 adenylate cyclase 8 HUGO:ADCY8 HGNC:239 ENTREZ:114 UNIPROT:P40145 GENECARDS:ADCY8 REACTOME:53246 KEGG:114 ATLASONC:GC_ADCY8 WIKI:ADCY8 adenylate cyclase 9 HUGO:ADCY9 HGNC:240 ENTREZ:115 UNIPROT:O60503 GENECARDS:ADCY9 REACTOME:53248 KEGG:115 WIKI:ADCY9 adenylate cyclase 10 HUGO:ADCY10 HGNC:21285 ENTREZ:55811 UNIPROT:Q96PN6 GENECARDS:ADCY10 KEGG:55811 ATLASONC:GC_ADCY10 WIKI:ADCY10 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Adenylyl_cyclase*"/> <bbox w="80.0" h="40.0" x="9523.0" y="645.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s894_wnc1_wnc1_sa592" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re111(MAP:survival): Rspo is required for clathrin-mediated endocytosis PMID:21397842 It has been shown that Dvl polymers are not associated with vesicles, therefore endocytosis of the complex is likely to be after Dvl polymerisation. PMID:16263762 s_wnc1_re113(MAP:survival): Rspo induces clathrin-mediated endocytosis References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: R-spondin 3 "R-spondin 3 homolog (Xenopus laevis)", "thrombospondin, type I, domain containing 2", THSD2 HUGO:RSPO3 HGNC:20866 ENTREZ:84870 UNIPROT:Q9BXY4 GENECARDS:RSPO3 KEGG:84870 ATLASONC:GC_RSPO3 WIKI:RSPO3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RSPO3"/> <bbox w="50.0" h="40.0" x="9133.5" y="2488.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s909_wnc1_wnc1_sa611" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end</body> </html> </notes> <label text="PRR*"/> <bbox w="80.0" h="40.0" x="9529.0" y="1524.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s944_wnc1_wnc1_sa645" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re122:(MAP:survival) PMID:12514131 s_wnc1_re123(MAP:survival): Akt phosphorylates POSH in the Rac1 binding domain, preventing binding of Rac1 w/ POSH PMID:17535800 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: SH3 domain containing ring finger 1 "SH3 multiple domains 2", SH3MD2 HUGO:SH3RF1 HGNC:17650 ENTREZ:57630 UNIPROT:Q7Z6J0 GENECARDS:SH3RF1 KEGG:57630 ATLASONC:GC_SH3RF1 WIKI:SH3RF1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="POSH*"/> <bbox w="80.0" h="40.0" x="8060.0" y="1512.0"/> <glyph class="state variable" id="_323dd505-6fb3-477c-8325-3f2755d28480"> <state value="" variable="S304"/> <bbox w="30.0" h="10.0" x="8125.0" y="1507.2147"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s948_wnc1_wnc1_sa648" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re123(MAP:survival): Akt phosphorylates POSH in the Rac1 binding domain, preventing binding of Rac1 w/ POSH PMID:17535800 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: SH3 domain containing ring finger 1 "SH3 multiple domains 2", SH3MD2 HUGO:SH3RF1 HGNC:17650 ENTREZ:57630 UNIPROT:Q7Z6J0 GENECARDS:SH3RF1 KEGG:57630 ATLASONC:GC_SH3RF1 WIKI:SH3RF1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="POSH*"/> <bbox w="80.0" h="40.0" x="8222.5" y="1513.0"/> <glyph class="state variable" id="_e8766a48-3d06-4d54-b1dc-0cb80165cd67"> <state value="P" variable="S304"/> <bbox w="35.0" h="10.0" x="8285.0" y="1508.2147"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s949_wnc1_wnc1_sa649" compartmentRef="wnc1_wnc1_c2_wnc1_wnc1_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> </notes> <label text="JUN"/> <bbox w="40.0" h="20.0" x="8104.0" y="1019.0"/> <glyph class="state variable" id="_53fbccdb-8b90-4ca9-9ac1-5b1e84d5ea10"> <state value="" variable="S63"/> <bbox w="25.0" h="10.0" x="8091.746" y="1014.0"/> </glyph> <glyph class="state variable" id="_d6697b88-03d8-436e-8b28-db9bd76afa4f"> <state value="" variable="S73"/> <bbox w="25.0" h="10.0" x="8111.516" y="1014.0"/> </glyph> <glyph class="state variable" id="_53fedae7-e18b-4320-8c54-c6d32e9e1eee"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8099.0" y="1024.0"/> </glyph> <glyph class="state variable" id="_ad301ac2-1a66-4bde-bbd8-59698118c856"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8099.0" y="1014.0"/> </glyph> <glyph class="state variable" id="_e73bf52e-9c96-466e-abf8-8eabd80ac815"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8099.0" y="1034.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s950_wnc1_wnc1_sa650" compartmentRef="wnc1_wnc1_c2_wnc1_wnc1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: jun B proto-oncogene HUGO:JUNB HGNC:6205 ENTREZ:3726 UNIPROT:P17275 GENECARDS:JUNB REACTOME:57681 KEGG:3726 ATLASONC:JUNBID178 WIKI:JUNB Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="JUNB"/> <bbox w="40.0" h="20.0" x="8207.0" y="1019.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s951_wnc1_wnc1_sa651" compartmentRef="wnc1_wnc1_c2_wnc1_wnc1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: jun D proto-oncogene HUGO:JUND HGNC:6206 ENTREZ:3727 UNIPROT:P17535 GENECARDS:JUND KEGG:3727 ATLASONC:JUNDID179 WIKI:JUND Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="JUND"/> <bbox w="40.0" h="20.0" x="8155.5" y="1019.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s975_wnc1_wnc1_sa679" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re140(MAP:survival): PMID:11779461 PMID:18256687 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dishevelled associated activator of morphogenesis 1 HUGO:DAAM1 HGNC:18142 ENTREZ:23002 UNIPROT:Q9Y4D1 GENECARDS:DAAM1 ATLASONC:GC_DAAM1 WIKI:DAAM1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="DAAM1"/> <bbox w="80.0" h="40.0" x="7346.0" y="2028.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s976_wnc1_wnc1_sa680" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re140(MAP:survival): PMID:11779461 PMID:18256687 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Rho guanine nucleotide exchange factor (GEF) 19 HUGO:ARHGEF19 HGNC:26604 ENTREZ:128272 UNIPROT:Q8IW93 GENECARDS:ARHGEF19 KEGG:128272 ATLASONC:GC_ARHGEF19 WIKI:ARHGEF19 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="WGEF*"/> <bbox w="80.0" h="40.0" x="7571.0" y="2051.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s979_wnc1_wnc1_sa683" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re146:(MAP:survival) Not sure if Rho dissociates when active References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ras homolog family member A ARH12, ARHA, "ras homolog gene family, member A" HUGO:RHOA HGNC:667 ENTREZ:387 UNIPROT:P61586 GENECARDS:RHOA REACTOME:63078 KEGG:387 ATLASONC:RHOAID42107ch3p21 WIKI:RHOA Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RHOA"/> <clone/> <bbox w="80.0" h="40.0" x="7345.0" y="2075.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s979_wnc1_wnc1_sa706" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re146:(MAP:survival) Not sure if Rho dissociates when active References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ras homolog family member A ARH12, ARHA, "ras homolog gene family, member A" HUGO:RHOA HGNC:667 ENTREZ:387 UNIPROT:P61586 GENECARDS:RHOA REACTOME:63078 KEGG:387 ATLASONC:RHOAID42107ch3p21 WIKI:RHOA Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RHOA"/> <clone/> <bbox w="80.0" h="40.0" x="7740.625" y="1534.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s1020_wnc1_wnc1_sa707" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Rho-associated, coiled-coil containing protein kinase 1 HUGO:ROCK1 HGNC:10251 ENTREZ:6093 UNIPROT:Q13464 GENECARDS:ROCK1 REACTOME:153167 KEGG:6093 ATLASONC:GC_ROCK1 WIKI:ROCK1 Rho-associated, coiled-coil containing protein kinase 2 HUGO:ROCK2 HGNC:10252 ENTREZ:9475 UNIPROT:O75116 GENECARDS:ROCK2 REACTOME:153173 KEGG:9475 ATLASONC:ROCK2ID43474ch2p25 WIKI:ROCK2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ROCK*"/> <bbox w="80.0" h="40.0" x="7857.0" y="1534.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s1028_wnc1_wnc1_sa712" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end</body> </html> </notes> <label text="PTEN"/> <bbox w="80.0" h="40.0" x="7819.0" y="1228.0"/> <glyph class="state variable" id="_b72dbe84-37ce-44e0-b52f-bc36f8d8c845"> <state value="" variable="S380"/> <bbox w="30.0" h="10.0" x="7854.2476" y="1223.0"/> </glyph> <glyph class="state variable" id="_d69515ed-e9e0-4cde-9fbd-ed294d7a250d"> <state value="" variable="S370"/> <bbox w="30.0" h="10.0" x="7883.6333" y="1223.0"/> </glyph> <glyph class="state variable" id="_aa525096-b749-4e7f-8273-b605b56a320d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7894.0" y="1263.0"/> </glyph> <glyph class="state variable" id="_3f3c083c-7cc5-4ec3-a96a-8cec8ab683b0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7814.0" y="1263.0"/> </glyph> <glyph class="state variable" id="_74d7900c-9f8e-4b68-8171-988b86bcf902"> <state value="" variable="K289"/> <bbox w="30.0" h="10.0" x="7844.7046" y="1263.0"/> </glyph> <glyph class="state variable" id="_0a45b224-4754-4a62-b540-62cecbd0dccb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7814.0" y="1223.0"/> </glyph> <glyph class="state variable" id="_ca938d77-b627-48c8-bc27-3b152f4ec08c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7894.0" y="1223.0"/> </glyph> <glyph class="state variable" id="_64de2dc3-673e-4684-8852-4f283c5c1de5"> <state value="" variable="K13"/> <bbox w="25.0" h="10.0" x="7806.74" y="1263.0"/> </glyph> <glyph class="state variable" id="_aa0d29e1-2608-42f6-98e4-93e654a46221"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="7804.0" y="1242.9681"/> </glyph> <glyph class="state variable" id="_dbf3f9fd-e8d1-4197-a9bf-6b71501d0c8b"> <state value="" variable="T366"/> <bbox w="30.0" h="10.0" x="7884.0" y="1243.0"/> </glyph> <glyph class="state variable" id="_f2f4221e-ea1f-444c-b680-c8b80110610c"> <state value="" variable="T383"/> <bbox w="30.0" h="10.0" x="7804.0" y="1225.4022"/> </glyph> <glyph class="state variable" id="_4e671bc8-6bf5-4330-883a-56537f467fd2"> <state value="" variable="T382"/> <bbox w="30.0" h="10.0" x="7832.532" y="1223.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s1039_wnc1_wnc1_sa719" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re158(MAP:survival): Mechanism is unknown, it is speculate that translocalisation occurs through calpain-sensitive proteins. PMID:21266584 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A ENTERZ:2931 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="GSK3α*"/> <bbox w="80.0" h="40.0" x="8607.0" y="748.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s1040_wnc1_wnc1_sa720" compartmentRef="wnc1_wnc1_c2_wnc1_wnc1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: It is explicitly, only GSK-3 alpha that is translocated PMID:21266584 s_wnc1_re158(MAP:survival): Mechanism is unknown, it is speculate that translocalisation occurs through calpain-sensitive proteins. References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A ENTERZ:2931 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="GSK3α*"/> <bbox w="80.0" h="40.0" x="8607.0" y="877.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s1041_wnc1_wnc1_sa722" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re159(MAP:survival): PMID:21670566 PMID:17593948 There are more mechanisms to activate Calpain PMID:16129881 s_wnc1_re158(MAP:survival): Mechanism is unknown, it is speculate that translocalisation occurs through calpain-sensitive proteins. PMID:21266584 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: calpain 1, (mu/I) large subunit HUGO:CAPN1 HGNC:1476 ENTREZ:823 UNIPROT:P07384 GENECARDS:CAPN1 KEGG:823 ATLASONC:GC_CAPN1 WIKI:CAPN1 calpain 2, (m/II) large subunit HUGO:CAPN2 HGNC:1479 ENTREZ:824 UNIPROT:P17655 GENECARDS:CAPN2 KEGG:824 ATLASONC:GC_CAPN2 WIKI:CAPN2 calpain 3, (p94) HUGO:CAPN3 HGNC:1480 ENTREZ:825 UNIPROT:P20807 GENECARDS:CAPN3 KEGG:825 ATLASONC:GC_CAPN3 WIKI:CAPN3 calpain 5 HUGO:CAPN5 HGNC:1482 ENTREZ:726 UNIPROT:O15484 GENECARDS:CAPN5 KEGG:726 ATLASONC:GC_CAPN5 WIKI:CAPN5 calpain 6 HUGO:CAPN6 HGNC:1483 ENTREZ:827 UNIPROT:Q9Y6Q1 GENECARDS:CAPN6 KEGG:827 ATLASONC:GC_CAPN6 WIKI:CAPN6 calpain 7 HUGO:CAPN7 HGNC:1484 ENTREZ:23473 UNIPROT:Q9Y6W3 GENECARDS:CAPN7 KEGG:23473 WIKI:CAPN7 calpain 8 HUGO:CAPN8 HGNC:1485 ENTREZ:388743 UNIPROT:A6NHC0 GENECARDS:CAPN8 KEGG:388743 WIKI:CAPN8 calpain 9 HUGO:CAPN9 HGNC:1486 ENTREZ:10753 UNIPROT:O14815 GENECARDS:CAPN9 KEGG:10753 ATLASONC:GC_CAPN9 WIKI:CAPN9 calpain 10 HUGO:CAPN10 HGNC:1477 ENTREZ:11132 UNIPROT:Q9HC96 GENECARDS:CAPN10 KEGG:11132 ATLASONC:GC_CAPN10 WIKI:CAPN10 calpain 11 HUGO:CAPN11 HGNC:1478 ENTREZ:11131 UNIPROT:Q9UMQ6 GENECARDS:CAPN11 KEGG:11131 WIKI:CAPN11 calpain 12 HUGO:CAPN12 HGNC:13249 ENTREZ:147968 UNIPROT:Q6ZSI9 GENECARDS:CAPN12 WIKI:CAPN12 calpain 13 HUGO:CAPN13 HGNC:16663 ENTREZ:92291 UNIPROT:Q6MZZ7 GENECARDS:CAPN13 WIKI:CAPN13 calpain 14 HUGO:CAPN14 HGNC:16664 ENTREZ:440854 UNIPROT:A8MX76 GENECARDS:CAPN14 WIKI:CAPN14 calpain 15 HUGO:SOLH HGNC:11182 ENTREZ:6650 UNIPROT:O75808 GENECARDS:SOLH KEGG:6650 WIKI:SOLH calpain, small subunit 1 HUGO:CAPNS1 HGNC:1481 ENTREZ:826 UNIPROT:P04632 GENECARDS:CAPNS1 KEGG:826 ATLASONC:GC_CAPNS1 WIKI:CAPNS1 calpain, small subunit 2 HUGO:CAPNS2 HGNC:16371 ENTREZ:84290 UNIPROT:Q96L46 GENECARDS:CAPNS2 WIKI:CAPNS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Calpain*"/> <clone/> <bbox w="80.0" h="40.0" x="8313.0" y="665.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s1041_wnc1_wnc1_sa727" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re159(MAP:survival): PMID:21670566 PMID:17593948 There are more mechanisms to activate Calpain PMID:16129881 s_wnc1_re158(MAP:survival): Mechanism is unknown, it is speculate that translocalisation occurs through calpain-sensitive proteins. PMID:21266584 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: calpain 1, (mu/I) large subunit HUGO:CAPN1 HGNC:1476 ENTREZ:823 UNIPROT:P07384 GENECARDS:CAPN1 KEGG:823 ATLASONC:GC_CAPN1 WIKI:CAPN1 calpain 2, (m/II) large subunit HUGO:CAPN2 HGNC:1479 ENTREZ:824 UNIPROT:P17655 GENECARDS:CAPN2 KEGG:824 ATLASONC:GC_CAPN2 WIKI:CAPN2 calpain 3, (p94) HUGO:CAPN3 HGNC:1480 ENTREZ:825 UNIPROT:P20807 GENECARDS:CAPN3 KEGG:825 ATLASONC:GC_CAPN3 WIKI:CAPN3 calpain 5 HUGO:CAPN5 HGNC:1482 ENTREZ:726 UNIPROT:O15484 GENECARDS:CAPN5 KEGG:726 ATLASONC:GC_CAPN5 WIKI:CAPN5 calpain 6 HUGO:CAPN6 HGNC:1483 ENTREZ:827 UNIPROT:Q9Y6Q1 GENECARDS:CAPN6 KEGG:827 ATLASONC:GC_CAPN6 WIKI:CAPN6 calpain 7 HUGO:CAPN7 HGNC:1484 ENTREZ:23473 UNIPROT:Q9Y6W3 GENECARDS:CAPN7 KEGG:23473 WIKI:CAPN7 calpain 8 HUGO:CAPN8 HGNC:1485 ENTREZ:388743 UNIPROT:A6NHC0 GENECARDS:CAPN8 KEGG:388743 WIKI:CAPN8 calpain 9 HUGO:CAPN9 HGNC:1486 ENTREZ:10753 UNIPROT:O14815 GENECARDS:CAPN9 KEGG:10753 ATLASONC:GC_CAPN9 WIKI:CAPN9 calpain 10 HUGO:CAPN10 HGNC:1477 ENTREZ:11132 UNIPROT:Q9HC96 GENECARDS:CAPN10 KEGG:11132 ATLASONC:GC_CAPN10 WIKI:CAPN10 calpain 11 HUGO:CAPN11 HGNC:1478 ENTREZ:11131 UNIPROT:Q9UMQ6 GENECARDS:CAPN11 KEGG:11131 WIKI:CAPN11 calpain 12 HUGO:CAPN12 HGNC:13249 ENTREZ:147968 UNIPROT:Q6ZSI9 GENECARDS:CAPN12 WIKI:CAPN12 calpain 13 HUGO:CAPN13 HGNC:16663 ENTREZ:92291 UNIPROT:Q6MZZ7 GENECARDS:CAPN13 WIKI:CAPN13 calpain 14 HUGO:CAPN14 HGNC:16664 ENTREZ:440854 UNIPROT:A8MX76 GENECARDS:CAPN14 WIKI:CAPN14 calpain 15 HUGO:SOLH HGNC:11182 ENTREZ:6650 UNIPROT:O75808 GENECARDS:SOLH KEGG:6650 WIKI:SOLH calpain, small subunit 1 HUGO:CAPNS1 HGNC:1481 ENTREZ:826 UNIPROT:P04632 GENECARDS:CAPNS1 KEGG:826 ATLASONC:GC_CAPNS1 WIKI:CAPNS1 calpain, small subunit 2 HUGO:CAPNS2 HGNC:16371 ENTREZ:84290 UNIPROT:Q96L46 GENECARDS:CAPNS2 WIKI:CAPNS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Calpain*"/> <clone/> <bbox w="80.0" h="40.0" x="8312.0" y="767.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s1045_wnc1_wnc1_sa723" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re160:(MAP:survival) PMID:19725819 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: calmodulin 1 (phosphorylase kinase, delta) CALML2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 2 (phosphorylase kinase, delta) HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 3 (phosphorylase kinase, delta) HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Calmodulin*"/> <bbox w="80.0" h="40.0" x="7473.0" y="788.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s494_wnc1_wnc1_sa359" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <clone/> <bbox w="80.0" h="40.0" x="8571.5" y="1858.5"/> <glyph class="state variable" id="_2db80726-22d8-4b30-863b-9810dd960781"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8566.5" y="1873.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s494_wnc1_wnc1_sa629" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <clone/> <bbox w="80.0" h="40.0" x="7955.5" y="1513.0"/> <glyph class="state variable" id="_5e6b4c4b-f56c-40ab-b057-782e6cf88939"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7950.5" y="1528.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s725_wnc1_wnc1_sa466" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re94:(MAP:survival) PMID:21262972 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide "tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide", YWHAA HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="YWHAB"/> <bbox w="80.0" h="40.0" x="8612.0" y="1201.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s1165_wnc1_wnc1_sa535" compartmentRef="wnc1_wnc1_c7_wnc1_wnc1_ca9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re105(MAP:survival): Acidification of the endosome is required for transducing the signal. The exact mechanism is unknown except that v-ATPase is involved in the process. PMID:20699474 PMID:21380625 s_wnc1_re119(MAP:survival): PRR binds to subunits ATP6V0C/D of the ATPase to lower the pH in the endosome. The reason for this is unknown but it is speculated that a lower pH is required for remodeling of the actin skeleton. However, v-ATPase is necessary for signaling PMID:21796133 PMID:20093472 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATPase H+ transporting lysosomal 16kDa V0 subunit c HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATPase H+ transporting lysosomal 38kDa V0 subunit d1 HUGO:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 GENECARDS:ATP6V0D1 REACTOME:67070 KEGG:9114 WIKI:ATP6V0D1 ATPase H+ transporting lysosomal 38kDa V0 subunit d2 HUGO/ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 HUGO:ATP6VOC GENECARDS:ATP6VOC WIKI:ATP6VOC HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATP6D, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d isoform 1", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit D1" HUOG:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 HUGO:ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 GENECARDS:ATP6V0D2 REACTOME:254033 KEGG:245972 WIKI:ATP6V0D2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20093472 References_end Identifiers_begin: ATPase H+ transporting lysosomal 16kDa V0 subunit c HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATPase H+ transporting lysosomal 38kDa V0 subunit d1 HUGO:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 GENECARDS:ATP6V0D1 REACTOME:67070 KEGG:9114 WIKI:ATP6V0D1 ATPase H+ transporting lysosomal 38kDa V0 subunit d2 HUGO/ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 HUGO:ATP6VOC GENECARDS:ATP6VOC WIKI:ATP6VOC HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATP6D, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d isoform 1", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit D1" HUOG:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 HUGO:ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 GENECARDS:ATP6V0D2 REACTOME:254033 KEGG:245972 WIKI:ATP6V0D2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20093472 References_end</body> </html> </notes> <label text="ATP6V0C_D*"/> <bbox w="80.0" h="40.0" x="7936.0" y="1880.0"/> <glyph class="unit of information" id="_38740861-c5f3-4b96-a2ab-8d69ec7e007e"> <label text="ion channel"/> <bbox w="60.0" h="10.0" x="7946.0" y="1875.0"/> </glyph> <glyph class="state variable" id="_701b531b-9aa8-4e0c-bf5b-4363b0b126a4"> <state value="open" variable=""/> <bbox w="30.0" h="10.0" x="7961.0" y="1915.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s1170_wnc1_wnc1_sa622" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re119(MAP:survival): PRR binds to subunits ATP6V0C/D of the ATPase to lower the pH in the endosome. The reason for this is unknown but it is speculated that a lower pH is required for remodeling of the actin skeleton. However, v-ATPase is necessary for signaling PMID:21796133 PMID:21380625 PMID:20093472 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATPase H+ transporting lysosomal 16kDa V0 subunit c HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATPase H+ transporting lysosomal 38kDa V0 subunit d1 HUGO:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 GENECARDS:ATP6V0D1 REACTOME:67070 KEGG:9114 WIKI:ATP6V0D1 ATPase H+ transporting lysosomal 38kDa V0 subunit d2 HUGO/ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 HUGO:ATP6VOC GENECARDS:ATP6VOC WIKI:ATP6VOC HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATP6D, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d isoform 1", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit D1" HUOG:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 HUGO:ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 GENECARDS:ATP6V0D2 REACTOME:254033 KEGG:245972 WIKI:ATP6V0D2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20093472 References_end Identifiers_begin: ATPase H+ transporting lysosomal 16kDa V0 subunit c HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATPase H+ transporting lysosomal 38kDa V0 subunit d1 HUGO:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 GENECARDS:ATP6V0D1 REACTOME:67070 KEGG:9114 WIKI:ATP6V0D1 ATPase H+ transporting lysosomal 38kDa V0 subunit d2 HUGO/ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 HUGO:ATP6VOC GENECARDS:ATP6VOC WIKI:ATP6VOC HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATP6D, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d isoform 1", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit D1" HUOG:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 HUGO:ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 GENECARDS:ATP6V0D2 REACTOME:254033 KEGG:245972 WIKI:ATP6V0D2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20093472 References_end</body> </html> </notes> <label text="ATP6V0C_D*"/> <bbox w="80.0" h="40.0" x="7755.5" y="2110.5"/> <glyph class="unit of information" id="_ea826aae-fb18-42e7-91b7-86836fd970de"> <label text="ion channel"/> <bbox w="60.0" h="10.0" x="7765.5" y="2105.5"/> </glyph> <glyph class="state variable" id="_b8be8ae9-2ab0-45ad-ac98-4f369716b6b2"> <state value="closed" variable=""/> <bbox w="40.0" h="10.0" x="7775.5" y="2145.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s1172_wnc1_wnc1_sa534" compartmentRef="wnc1_wnc1_c7_wnc1_wnc1_ca9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re137(MAP:survival): Acidification of the endosome is required for transducing the signal. The exact mechanism is unknown except that v-ATPase is involved in the process. PMID:20699474 PMID:21380625 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATPase H+ transporting lysosomal 16kDa V0 subunit c HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATPase H+ transporting lysosomal 38kDa V0 subunit d1 HUGO:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 GENECARDS:ATP6V0D1 REACTOME:67070 KEGG:9114 WIKI:ATP6V0D1 ATPase H+ transporting lysosomal 38kDa V0 subunit d2 HUGO/ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 HUGO:ATP6VOC GENECARDS:ATP6VOC WIKI:ATP6VOC HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATP6D, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d isoform 1", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit D1" HUOG:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 HUGO:ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 GENECARDS:ATP6V0D2 REACTOME:254033 KEGG:245972 WIKI:ATP6V0D2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20093472 References_end Identifiers_begin: ATPase H+ transporting lysosomal 16kDa V0 subunit c HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATPase H+ transporting lysosomal 38kDa V0 subunit d1 HUGO:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 GENECARDS:ATP6V0D1 REACTOME:67070 KEGG:9114 WIKI:ATP6V0D1 ATPase H+ transporting lysosomal 38kDa V0 subunit d2 HUGO/ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 HUGO:ATP6VOC GENECARDS:ATP6VOC WIKI:ATP6VOC HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATP6D, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d isoform 1", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit D1" HUOG:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 HUGO:ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 GENECARDS:ATP6V0D2 REACTOME:254033 KEGG:245972 WIKI:ATP6V0D2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20093472 References_end</body> </html> </notes> <label text="ATP6V0C_D*"/> <clone/> <bbox w="80.0" h="40.0" x="7776.0" y="1880.0"/> <glyph class="unit of information" id="_5a6f6df3-0acb-4d09-ae6c-947573c17579"> <label text="ion channel"/> <bbox w="60.0" h="10.0" x="7786.0" y="1875.0"/> </glyph> <glyph class="state variable" id="_a9e3d43b-91f8-473d-b5cc-eb2808ccaa68"> <state value="closed" variable=""/> <bbox w="40.0" h="10.0" x="7796.0" y="1915.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s1172_wnc1_wnc1_sa656" compartmentRef="wnc1_wnc1_c7_wnc1_wnc1_ca9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re137(MAP:survival): Acidification of the endosome is required for transducing the signal. The exact mechanism is unknown except that v-ATPase is involved in the process. PMID:20699474 PMID:21380625 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATPase H+ transporting lysosomal 16kDa V0 subunit c HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATPase H+ transporting lysosomal 38kDa V0 subunit d1 HUGO:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 GENECARDS:ATP6V0D1 REACTOME:67070 KEGG:9114 WIKI:ATP6V0D1 ATPase H+ transporting lysosomal 38kDa V0 subunit d2 HUGO/ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 HUGO:ATP6VOC GENECARDS:ATP6VOC WIKI:ATP6VOC HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATP6D, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d isoform 1", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit D1" HUOG:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 HUGO:ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 GENECARDS:ATP6V0D2 REACTOME:254033 KEGG:245972 WIKI:ATP6V0D2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20093472 References_end Identifiers_begin: ATPase H+ transporting lysosomal 16kDa V0 subunit c HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATPase H+ transporting lysosomal 38kDa V0 subunit d1 HUGO:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 GENECARDS:ATP6V0D1 REACTOME:67070 KEGG:9114 WIKI:ATP6V0D1 ATPase H+ transporting lysosomal 38kDa V0 subunit d2 HUGO/ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 HUGO:ATP6VOC GENECARDS:ATP6VOC WIKI:ATP6VOC HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATP6D, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d isoform 1", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit D1" HUOG:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 HUGO:ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 GENECARDS:ATP6V0D2 REACTOME:254033 KEGG:245972 WIKI:ATP6V0D2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20093472 References_end</body> </html> </notes> <label text="ATP6V0C_D*"/> <clone/> <bbox w="80.0" h="40.0" x="8097.75" y="2251.5"/> <glyph class="unit of information" id="_10125c60-d534-4644-9535-18bf0bde7f93"> <label text="ion channel"/> <bbox w="60.0" h="10.0" x="8107.75" y="2246.5"/> </glyph> <glyph class="state variable" id="_4bcd17a6-7e40-4e42-83b3-1cbe81131087"> <state value="closed" variable=""/> <bbox w="40.0" h="10.0" x="8117.75" y="2286.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc1_s1172_wnc1_wnc1_sa657" compartmentRef="wnc1_wnc1_c7_wnc1_wnc1_ca9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re137(MAP:survival): Acidification of the endosome is required for transducing the signal. The exact mechanism is unknown except that v-ATPase is involved in the process. PMID:20699474 PMID:21380625 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATPase H+ transporting lysosomal 16kDa V0 subunit c HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATPase H+ transporting lysosomal 38kDa V0 subunit d1 HUGO:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 GENECARDS:ATP6V0D1 REACTOME:67070 KEGG:9114 WIKI:ATP6V0D1 ATPase H+ transporting lysosomal 38kDa V0 subunit d2 HUGO/ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 HUGO:ATP6VOC GENECARDS:ATP6VOC WIKI:ATP6VOC HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATP6D, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d isoform 1", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit D1" HUOG:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 HUGO:ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 GENECARDS:ATP6V0D2 REACTOME:254033 KEGG:245972 WIKI:ATP6V0D2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20093472 References_end Identifiers_begin: ATPase H+ transporting lysosomal 16kDa V0 subunit c HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATPase H+ transporting lysosomal 38kDa V0 subunit d1 HUGO:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 GENECARDS:ATP6V0D1 REACTOME:67070 KEGG:9114 WIKI:ATP6V0D1 ATPase H+ transporting lysosomal 38kDa V0 subunit d2 HUGO/ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 HUGO:ATP6VOC GENECARDS:ATP6VOC WIKI:ATP6VOC HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATP6D, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d isoform 1", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit D1" HUOG:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 HUGO:ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 GENECARDS:ATP6V0D2 REACTOME:254033 KEGG:245972 WIKI:ATP6V0D2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20093472 References_end</body> </html> </notes> <label text="ATP6V0C_D*"/> <clone/> <bbox w="80.0" h="40.0" x="8257.75" y="2251.5"/> <glyph class="unit of information" id="_8213f0aa-b340-47ab-86f6-dff202f62da5"> <label text="ion channel"/> <bbox w="60.0" h="10.0" x="8267.75" y="2246.5"/> </glyph> <glyph class="state variable" id="_245fd9c7-07c9-4871-a6e0-3de2cd6c6fd7"> <state value="open" variable=""/> <bbox w="30.0" h="10.0" x="8282.75" y="2286.5"/> </glyph> </glyph> <glyph class="phenotype" id="wnc1_s_wnc1_s9_wnc1_wnc1_sa8" compartmentRef="wnc1_wnc1_c2_wnc1_wnc1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re52(MAP:survival): PMID:21506126 This phosphorylated form of b-catenin facilitates interaction between b-catenin and CBP PMID:16476742 References_end</body> </html> </notes> <label text="Transcription"/> <bbox w="80.0" h="30.0" x="8260.5" y="918.4149"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc1_s105_wnc1_wnc1_sa95" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <label text="Apoptosis"/> <bbox w="80.0" h="30.0" x="8701.0" y="555.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc1_s412_wnc1_wnc1_sa320" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <label text="EMT"/> <bbox w="80.0" h="30.0" x="8809.0" y="561.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc1_s792_wnc1_wnc1_sa514" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re113(MAP:survival): Rspo induces clathrin-mediated endocytosis PMID:21397842 References_end</body> </html> </notes> <label text="Clathrin-mediated endocytosis"/> <bbox w="80.0" h="30.0" x="9001.0" y="2418.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc1_s929_wnc1_wnc1_sa628" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <label text="JNK pathway"/> <bbox w="80.0" h="30.0" x="8167.0" y="1390.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc1_s952_wnc1_wnc1_sa652" compartmentRef="wnc1_wnc1_c2_wnc1_wnc1_ca2"> <label text="DNA repair"/> <bbox w="80.0" h="30.0" x="8388.0" y="949.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc1_s955_wnc1_wnc1_sa655" compartmentRef="wnc1_wnc1_c2_wnc1_wnc1_ca2"> <label text="Proliferation"/> <bbox w="80.0" h="30.0" x="8387.0" y="867.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc1_s982_wnc1_wnc1_sa686" compartmentRef="wnc1_wnc1_c2_wnc1_wnc1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re143(MAP:survival): Activated Daam1 is responisble for the inhibition PMID:20351293 Referenes_end References_end</body> </html> </notes> <label text="Angiogenesis"/> <bbox w="80.0" h="30.0" x="8479.0" y="909.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc1_s983_wnc1_wnc1_sa687" compartmentRef="wnc1_wnc1_c2_wnc1_wnc1_ca2"> <label text="Centrosome positioning"/> <bbox w="80.0" h="30.0" x="8482.0" y="961.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc1_s1026_wnc1_wnc1_sa710" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <label text="Microtubules"/> <bbox w="80.0" h="30.0" x="7312.0" y="1268.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc1_s1027_wnc1_wnc1_sa711" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <label text="Cell contraction"/> <bbox w="80.0" h="30.0" x="7315.0" y="1329.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc1_s118_wnc1_wnc1_sa102" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <label text="PI3K AKT MTOR pathway"/> <bbox w="80.0" h="30.0" x="7879.0" y="888.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc1_s138_wnc1_wnc1_sa117" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <label text="MAPK pathway"/> <bbox w="80.0" h="30.0" x="7751.0" y="928.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc1_s70_wnc1_wnc1_sa56" compartmentRef="wnc1_wnc1_c2_wnc1_wnc1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re16(MAP:survival): It is possible that the signalling downstream occurs as for the canonical MODULE PMID:20223821 References_end</body> </html> </notes> <label text="β-catenin stability"/> <bbox w="80.0" h="30.0" x="8260.5" y="875.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc1_s954_wnc1_wnc1_sa654" compartmentRef="wnc1_wnc1_c2_wnc1_wnc1_ca2"> <label text="Growth arrest"/> <bbox w="80.0" h="30.0" x="8388.0" y="909.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc1_s953_wnc1_wnc1_sa653" compartmentRef="wnc1_wnc1_c2_wnc1_wnc1_ca2"> <label text="Cell death"/> <bbox w="80.0" h="30.0" x="8387.0" y="998.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc1_s981_wnc1_wnc1_sa685" compartmentRef="wnc1_wnc1_c2_wnc1_wnc1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re142(MAP:survival): Activated Daam1 is responisble for the inhibition PMID:20351293 s_wnc1_re154(MAP:survival): PTEN contains a C2-domain which inhibits cell migration. This inhibition works only when T383 is not phosphorylated PMID:14976311 However, beta-arrestin can also bind PTEN in this C2-region thereby dis-inhibiting migration. PMID:21642958 References_end</body> </html> </notes> <label text="Cell migration"/> <bbox w="80.0" h="30.0" x="8480.0" y="867.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc1_s984_wnc1_wnc1_sa688" compartmentRef="wnc1_wnc1_c2_wnc1_wnc1_ca2"> <label text="Actin polymerization"/> <bbox w="80.0" h="30.0" x="8485.0" y="1004.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc1_s104_wnc1_wnc1_sa94" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <label text="WNT canonical pathway"/> <bbox w="80.0" h="30.0" x="8701.0" y="503.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc1_s1035_wnc1_wnc1_sa718" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re155:(MAP:survival) PMID:21619876 References_end</body> </html> </notes> <label text="STAT3 pathway"/> <bbox w="80.0" h="30.0" x="8168.0" y="1435.0"/> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc1_s1173_wnc1_wnc1_sa658" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <label text="H+"/> <bbox w="25.0" h="25.0" x="8296.75" y="2210.5"/> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc1_s1174_wnc1_wnc1_sa536" compartmentRef="wnc1_wnc1_c7_wnc1_wnc1_ca9"> <label text="H+"/> <clone/> <bbox w="25.0" h="25.0" x="7975.0" y="1839.0"/> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc1_s1174_wnc1_wnc1_sa537" compartmentRef="wnc1_wnc1_c7_wnc1_wnc1_ca9"> <label text="H+"/> <clone/> <bbox w="25.0" h="25.0" x="7976.0" y="1950.0"/> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc1_s1174_wnc1_wnc1_sa659" compartmentRef="wnc1_wnc1_c7_wnc1_wnc1_ca9"> <label text="H+"/> <clone/> <bbox w="25.0" h="25.0" x="8296.75" y="2321.5"/> </glyph> <glyph class="source and sink" id="wnc1_s_wnc1_s564_wnc1_wnc1_sa398" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <label text="26S proteosomal degradation"/> <bbox w="30.0" h="30.0" x="8584.0" y="1962.0"/> </glyph> <glyph class="source and sink" id="wnc1_s_wnc1_s732_wnc1_wnc1_sa471" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <label text="wnc1_s_wnc1_s732"/> <bbox w="30.0" h="30.0" x="8799.0" y="1473.0"/> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s46_wnc1_wnc1_csa5" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:G_beta_*:G_gamma_* Identifiers_end References_begin: Ca2+/Wnt MODULE References_end</body> </html> </notes> <label text="Gβ*:Gγ*"/> <bbox w="90.0" h="50.0" x="7858.0" y="336.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s19_wnc1_wnc1_sa20"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="7862.0" y="347.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s20_wnc1_wnc1_sa21"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="7903.0" y="347.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s58_wnc1_wnc1_csa8" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GTP:G_alpha__sub_13q_endsub_*:_beta_-Arrestin* Identifiers_end References_begin: Ca2+/Wnt MODULE s_wnc1_re11:(MAP:survival) PMID:20223821 s_wnc1_re22(MAP:survival): Only the Galpha_q subunit can activate PLC-beta PMID:11395409 PMID:19359428 References_end</body> </html> </notes> <label text="GTP:Gα13q*:β-Arrestin*"/> <bbox w="105.0" h="97.0" x="7754.0" y="407.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s60_wnc1_wnc1_sa19"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Gα13q*"/> <bbox w="50.0" h="20.0" x="7780.0" y="416.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s59_wnc1_wnc1_sa50"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: arrestin, beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 arrestin, beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="β-Arrestin*"/> <bbox w="80.0" h="40.0" x="7765.5" y="439.0"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc1_s151_wnc1_wnc1_sa124"> <label text="GTP"/> <bbox w="25.0" h="25.0" x="7829.5" y="407.5"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s61_wnc1_wnc1_csa6" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DVL*:G_alpha__sub_13q_endsub_*:_beta_-Arrestin* Identifiers_end References_begin: s_wnc1_re11:(MAP:survival) PMID:20223821 s_wnc1_re16(MAP:survival): It is possible that the signalling downstream occurs as for the canonical MODULE PMID:20223821 References_end</body> </html> </notes> <label text="DVL*:Gα13q*:β-Arrestin*"/> <bbox w="104.0" h="142.0" x="7424.0" y="494.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s68_wnc1_wnc1_sa42"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="7434.75" y="531.0"/> <glyph class="state variable" id="_5cca027d-4af3-44b4-8136-8e6da643ba77"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7509.75" y="526.0"/> </glyph> <glyph class="state variable" id="_185eae48-5752-44e3-863d-07ad75beb2eb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7429.75" y="526.0"/> </glyph> <glyph class="state variable" id="_dc1098b9-259c-4f75-8827-55e7cf3cf848"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="7499.132" y="566.0"/> </glyph> <glyph class="state variable" id="_bf27de43-4a4b-40bd-90f5-354b756f4a70"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7429.75" y="526.0"/> </glyph> <glyph class="state variable" id="_933dc07d-b8bf-4a34-a779-6914293c4e0e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7509.75" y="526.0"/> </glyph> <glyph class="state variable" id="_54852e3d-cb64-4363-ae64-6bc9f5a590db"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7506.8833" y="526.0"/> </glyph> <glyph class="state variable" id="_67abab84-2b6c-46da-93b7-e94dd2f440cf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7509.75" y="566.0"/> </glyph> <glyph class="state variable" id="_2651c806-d580-4795-bb5d-f11cccd947b0"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="7419.75" y="565.7223"/> </glyph> <glyph class="state variable" id="_5c8dfd1d-999f-4316-bf50-d0dc3f2f59f1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7429.75" y="566.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s48_wnc1_wnc1_sa43"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Gα13q*"/> <bbox w="50.0" h="20.0" x="7450.5" y="507.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s56_wnc1_wnc1_sa49"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: arrestin, beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 arrestin, beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="β-Arrestin*"/> <bbox w="80.0" h="40.0" x="7436.5" y="573.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s62_wnc1_wnc1_csa9" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DVL*:G_alpha__sub_13q_endsub_*:_beta_-Arrestin* Identifiers_end</body> </html> </notes> <label text="DVL*:Gα13q*:β-Arrestin*"/> <bbox w="104.0" h="142.0" x="7149.5" y="494.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s69_wnc1_wnc1_sa52"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="7160.25" y="531.0"/> <glyph class="state variable" id="_8e96599a-7e65-42c7-82a1-5e7765577690"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7235.25" y="526.0"/> </glyph> <glyph class="state variable" id="_a51d71cb-8511-410c-88d4-8dafc71a93eb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7155.25" y="526.0"/> </glyph> <glyph class="state variable" id="_6f7c7a15-a959-435c-bc0b-fed86bf69d1c"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="7224.632" y="566.0"/> </glyph> <glyph class="state variable" id="_2b9cd68c-d814-42f3-978c-332177befc8d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7155.25" y="526.0"/> </glyph> <glyph class="state variable" id="_d642585c-7f13-43a4-88ad-2e3788625c7e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7235.25" y="526.0"/> </glyph> <glyph class="state variable" id="_33150097-6af1-4718-98fa-6f27a1c667eb"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7232.3833" y="526.0"/> </glyph> <glyph class="state variable" id="_e6b64e3d-30ec-41f0-9d49-0651af00299e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7235.25" y="566.0"/> </glyph> <glyph class="state variable" id="_4058397b-1a91-4916-9a4f-fe7cb316b642"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="7145.25" y="565.7223"/> </glyph> <glyph class="state variable" id="_a0c6268c-fda2-4734-8cdf-868ac4e182b9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7155.25" y="566.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s64_wnc1_wnc1_sa53"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Gα13q*"/> <bbox w="50.0" h="20.0" x="7176.0" y="507.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s65_wnc1_wnc1_sa54"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: arrestin, beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 arrestin, beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="β-Arrestin*"/> <bbox w="80.0" h="40.0" x="7162.0" y="573.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s77_wnc1_wnc1_csa10" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:LGR5:RSPO1-4* Identifiers_end References_begin: s_wnc1_re18:(MAP:survival) PMID:21693646 s_wnc1_re19(MAP:survival): PMID:21727895 PMID:21909076 References_end</body> </html> </notes> <label text="LGR5:RSPO1-4*"/> <bbox w="100.0" h="120.0" x="8166.0" y="226.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s79_wnc1_wnc1_sa59"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: R-spondin 1 HUGO:RSPO1 HGNC:21679 ENTREZ:284654 UNIPROT:Q2MKA7 GENECARDS:RSPO1 KEGG:284654 ATLASONC:RSPO1ID44137ch1p34 WIKI:RSPO1 R-spondin 2 HUGO:RSPO2 HGNC:28583 ENTREZ:340419 UNIPROT:Q6UXX9 GENECARDS:RSPO2 KEGG:340419 ATLASONC:GC_RSPO2 WIKI:RSPO2 R-spondin 3 HUGO:RSPO3 HGNC:20866 ENTREZ:84870 UNIPROT:Q9BXY4 GENECARDS:RSPO3 KEGG:84870 ATLASONC:GC_RSPO3 WIKI:RSPO3 R-spondin 4 HUGO:RSPO4 HGNC:16175 ENTREZ:343637 UNIPROT:Q2I0M5 GENECARDS:RSPO4 KEGG:343637 WIKI:RSPO4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RSPO1-4*"/> <bbox w="40.0" h="30.0" x="8192.5" y="239.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s78_wnc1_wnc1_sa60"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: leucine-rich repeat containing G protein-coupled receptor 5 "G protein-coupled receptor 49", GPR49, GPR67, "leucine-rich repeat-containing G protein-coupled receptor 5" HUGO:LGR5 HGNC:4504 ENTREZ:8549 UNIPROT:O75473 GENECARDS:LGR5 KEGG:8549 ATLASONC:GC_LGR5 WIKI:LGR5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LGR5"/> <bbox w="80.0" h="50.0" x="8175.5" y="266.5"/> <glyph class="unit of information" id="_e53ac3cf-9de0-4316-911f-d71ab62db032"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8193.0" y="261.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s89_wnc1_wnc1_csa11" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK1_epsilon_*:E-Cadherin*:FZD*:GTP:G_alpha_*:G_beta_*:G_gamma_*:LRP5_6*:WNT*:p120* Identifiers_end References_begin: s_wnc1_re19(MAP:survival): PMID:21727895 PMID:21909076 References_end</body> </html> </notes> <label text="CK1ε*:E-Cadherin*:FZD*:GTP:Gα*:Gβ*:Gγ*:LRP5_6*:WNT*:p120*"/> <bbox w="238.0" h="189.0" x="8316.0" y="196.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s92_wnc1_wnc1_sa61"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="8331.0" y="228.0"/> <glyph class="unit of information" id="_3147462b-b2e7-469b-886b-2fc2a1485bdf"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8348.5" y="223.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s93_wnc1_wnc1_sa62"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="8331.0" y="272.0"/> <glyph class="state variable" id="_6c4b9663-7ee7-43c5-acb1-ecec4eec11d8"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="8313.5" y="291.96017"/> </glyph> <glyph class="state variable" id="_ca6df419-ecd1-4bec-90a4-8c8d30837d11"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="8353.532" y="267.0"/> </glyph> <glyph class="state variable" id="_8fa8e0fd-c697-4967-8c35-663408ebb51c"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="8393.5" y="267.26846"/> </glyph> <glyph class="state variable" id="_aa452b4f-022c-49f5-a9a6-4570dd8bc95a"> <state value="" variable="S1496"/> <bbox w="35.0" h="10.0" x="8392.882" y="317.0"/> </glyph> <glyph class="state variable" id="_1e06e7b4-3275-46f7-8126-2b909abcd3ba"> <state value="" variable="T1530"/> <bbox w="35.0" h="10.0" x="8352.6045" y="317.0"/> </glyph> <glyph class="state variable" id="_3c664718-bf0b-440c-94b2-216c8bb98cf5"> <state value="" variable="S1533"/> <bbox w="35.0" h="10.0" x="8313.74" y="317.0"/> </glyph> <glyph class="unit of information" id="_1d75e8f0-65b7-467a-b7f8-a8390a180cda"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8348.5" y="267.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s94_wnc1_wnc1_sa63"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="55.0" h="105.0" x="8413.0" y="209.0"/> <glyph class="state variable" id="_3898db14-3330-4f02-8b9b-371b4d5881ee"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8463.0" y="204.0"/> </glyph> <glyph class="state variable" id="_ade4477b-64cf-4176-b616-5933c211b9ad"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="8398.877" y="204.0"/> </glyph> <glyph class="state variable" id="_d61ed475-6345-488c-9dac-28fdd3e5c7b7"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="8453.0" y="204.56377"/> </glyph> <glyph class="state variable" id="_f2380a20-6384-4746-8a62-25d1993f8bb4"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="8450.996" y="309.0"/> </glyph> <glyph class="state variable" id="_e8467552-5fc0-42f0-835a-f97a99101e42"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="8398.165" y="309.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s95_wnc1_wnc1_sa64"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="8468.0" y="279.0"/> <glyph class="state variable" id="_2e7f999f-aa90-41d3-87ed-27093063d214"> <state value="" variable="S268"/> <bbox w="30.0" h="10.0" x="8453.492" y="274.0"/> </glyph> <glyph class="state variable" id="_7c9bdd83-3990-4525-94ee-78953b9e296b"> <state value="" variable="S269"/> <bbox w="30.0" h="10.0" x="8493.032" y="274.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s96_wnc1_wnc1_sa65"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="8468.0" y="320.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s97_wnc1_wnc1_sa66"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 5Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Gα*"/> <bbox w="40.0" h="20.0" x="8323.0" y="324.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s98_wnc1_wnc1_sa67"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="8364.25" y="324.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s99_wnc1_wnc1_sa68"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="8405.25" y="324.0"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc1_s100_wnc1_wnc1_sa70"> <label text="GTP"/> <bbox w="25.0" h="25.0" x="8336.5" y="342.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s101_wnc1_wnc1_sa71"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="8350.0" y="210.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s91_wnc1_wnc1_csa12" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK1_epsilon_*:E-Cadherin*:FZD*:GTP:G_alpha_*:G_beta_*:G_gamma_*:LGR5:LRP5_6*:RSPO1-4*:WNT*:p120* Identifiers_end References_begin: s_wnc1_re19(MAP:survival): PMID:21727895 PMID:21909076 s_wnc1_re20(MAP:survival): Association of LGR5 w/ Wnt-receptors leads to synergistic TOPFLASH reporter activity LGR5 antagonises Wnt signalling PMID:21829496 References_end</body> </html> </notes> <label text="CK1ε*:E-Cadherin*:FZD*:GTP:Gα*:Gβ*:Gγ*:LGR5:LRP5_6*:RSPO1-4*:WNT*:p120*"/> <bbox w="324.0" h="191.0" x="8580.0" y="194.5"/> <glyph class="macromolecule" id="wnc1_wnc1_s80_wnc1_wnc1_sa72"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="8681.0" y="226.5"/> <glyph class="unit of information" id="_7db74b44-6308-406a-b632-361b1221f39c"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8698.5" y="221.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s81_wnc1_wnc1_sa73"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="8681.0" y="270.5"/> <glyph class="state variable" id="_c469e14c-88af-47bc-b3a0-a0ddfa16aa98"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="8663.5" y="290.46017"/> </glyph> <glyph class="state variable" id="_27d4e36c-2831-48fb-9300-8c92d8a82e2d"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="8703.532" y="265.5"/> </glyph> <glyph class="state variable" id="_d61af8a7-494b-4079-9562-ea0802f145b2"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="8743.5" y="265.76846"/> </glyph> <glyph class="state variable" id="_160c4bde-5dc8-496f-8c84-64b2bb5dfc68"> <state value="" variable="S1496"/> <bbox w="35.0" h="10.0" x="8742.882" y="315.5"/> </glyph> <glyph class="state variable" id="_87967406-86d2-40ab-9488-ef36b6027cec"> <state value="" variable="T1530"/> <bbox w="35.0" h="10.0" x="8702.6045" y="315.5"/> </glyph> <glyph class="state variable" id="_dd630ebb-d386-4eed-ba55-73b36aacb7ea"> <state value="" variable="S1533"/> <bbox w="35.0" h="10.0" x="8663.74" y="315.5"/> </glyph> <glyph class="unit of information" id="_b6a75238-4758-4bd4-991e-f7359c66d26c"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8698.5" y="265.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s82_wnc1_wnc1_sa74"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="55.0" h="105.0" x="8763.0" y="207.5"/> <glyph class="state variable" id="_2e9cb550-9c45-43b9-ad71-e752f314a2f7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8813.0" y="202.5"/> </glyph> <glyph class="state variable" id="_cb0fe025-7436-4d8b-8ab8-784aeb55d97b"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="8748.877" y="202.5"/> </glyph> <glyph class="state variable" id="_212134eb-10de-4f8b-aa18-29e585f44159"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="8803.0" y="203.06377"/> </glyph> <glyph class="state variable" id="_213a18f1-7846-47ff-8a6d-89159847fd22"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="8800.996" y="307.5"/> </glyph> <glyph class="state variable" id="_13b3819f-fc62-438b-8c6f-1e6549bc146f"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="8748.165" y="307.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s83_wnc1_wnc1_sa75"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="8818.0" y="277.5"/> <glyph class="state variable" id="_e51c0abe-5f7d-46cd-b6bf-c3550b0dba8b"> <state value="" variable="S268"/> <bbox w="30.0" h="10.0" x="8803.492" y="272.5"/> </glyph> <glyph class="state variable" id="_10298ade-1333-47dd-afc2-f2f89ed8eaf3"> <state value="" variable="S269"/> <bbox w="30.0" h="10.0" x="8843.032" y="272.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s84_wnc1_wnc1_sa76"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="8818.0" y="318.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s85_wnc1_wnc1_sa77"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 5Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Gα*"/> <bbox w="40.0" h="20.0" x="8673.0" y="322.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s86_wnc1_wnc1_sa78"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="8714.25" y="322.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s87_wnc1_wnc1_sa79"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="8755.25" y="322.5"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc1_s90_wnc1_wnc1_sa80"> <label text="GTP"/> <bbox w="25.0" h="25.0" x="8686.5" y="340.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s88_wnc1_wnc1_sa81"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="8702.0" y="212.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s102_wnc1_wnc1_sa92"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: leucine-rich repeat containing G protein-coupled receptor 5 "G protein-coupled receptor 49", GPR49, GPR67, "leucine-rich repeat-containing G protein-coupled receptor 5" HUGO:LGR5 HGNC:4504 ENTREZ:8549 UNIPROT:O75473 GENECARDS:LGR5 KEGG:8549 ATLASONC:GC_LGR5 WIKI:LGR5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LGR5"/> <bbox w="80.0" h="50.0" x="8599.0" y="268.0"/> <glyph class="unit of information" id="_656aff06-4646-4169-8c69-9c94ff756733"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8616.5" y="263.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s103_wnc1_wnc1_sa93"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: R-spondin 1 HUGO:RSPO1 HGNC:21679 ENTREZ:284654 UNIPROT:Q2MKA7 GENECARDS:RSPO1 KEGG:284654 ATLASONC:RSPO1ID44137ch1p34 WIKI:RSPO1 R-spondin 2 HUGO:RSPO2 HGNC:28583 ENTREZ:340419 UNIPROT:Q6UXX9 GENECARDS:RSPO2 KEGG:340419 ATLASONC:GC_RSPO2 WIKI:RSPO2 R-spondin 3 HUGO:RSPO3 HGNC:20866 ENTREZ:84870 UNIPROT:Q9BXY4 GENECARDS:RSPO3 KEGG:84870 ATLASONC:GC_RSPO3 WIKI:RSPO3 R-spondin 4 HUGO:RSPO4 HGNC:16175 ENTREZ:343637 UNIPROT:Q2I0M5 GENECARDS:RSPO4 KEGG:343637 WIKI:RSPO4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RSPO1-4*"/> <bbox w="40.0" h="30.0" x="8616.0" y="242.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s115_wnc1_wnc1_csa14" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:G_alpha__sub_13q_endsub_*:PLC-_beta_*:_beta_-Arrestin* Identifiers_end References_begin: Ca2+/Wnt MODULE s_wnc1_re22(MAP:survival): Only the Galpha_q subunit can activate PLC-beta PMID:11395409 PMID:19359428 s_wnc1_re26:(MAP:survival) PMID:16054198 References_end</body> </html> </notes> <label text="Gα13q*:PLC-β*:β-Arrestin*"/> <bbox w="95.0" h="151.0" x="7152.0" y="669.5"/> <glyph class="macromolecule" id="wnc1_wnc1_s108_wnc1_wnc1_sa97"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Gα13q*"/> <bbox w="50.0" h="20.0" x="7174.0" y="678.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s109_wnc1_wnc1_sa98"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: arrestin, beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 arrestin, beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="β-Arrestin*"/> <bbox w="80.0" h="40.0" x="7159.5" y="701.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s110_wnc1_wnc1_sa99"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: phospholipase C, beta 1 (phosphoinositide-specific) HUGO:PLCB1 HGNC:15917 ENTREZ:23236 UNIPROT:Q9NQ66 GENECARDS:PLCB1 REACTOME:61694 KEGG:23236 ATLASONC:PLCB1ID41742ch20p12 WIKI:PLCB1 phospholipase C, beta 2 (phosphoinositide-specific) HUGO:PLCB2 HGNC:9055 ENTREZ:5330 UNIPROT:Q00722 GENECARDS:PLCB2 REACTOME:61696 ATLASONC:PLCB2ID41743ch15q15 WIKI:PLCB2 phospholipase C, beta 3 (phosphoinositide-specific) HUGO:PLCB3 HGNC:9056 ENTREZ:5331 UNIPROT:Q01970 GENECARDS:PLCB3 REACTOME:61748 ATLASONC:GC_PLCB3 WIKI:PLCB3 phospholipase C, beta 4 (phosphoinositide-specific) HUGO:PLCB4 HGNC:9059 ENTREZ:5332 UNIPROT:Q15147 GENECARDS:PLCB4 REACTOME:61698 KEGG:5332 ATLASONC:GC_PLCB4 WIKI:PLCB4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PLC-β*"/> <bbox w="80.0" h="40.0" x="7159.5" y="742.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s120_wnc1_wnc1_csa15" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CAMK2*:Ca2+:Calmodulin* Identifiers_end References_begin: [Ca2+/Wnt MODULE] Activation depends on Ca2+ concentration s_wnc1_re23:(MAP:survival) PMID:9859994 s_wnc2_re49:(MAP:survival) PMID:2550447, PMID:19608982 References_end</body> </html> </notes> <label text="CAMK2*:Ca2+:Calmodulin*"/> <bbox w="109.0" h="157.0" x="7734.0" y="726.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s122_wnc1_wnc1_sa105"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: calcium/calmodulin-dependent protein kinase II alpha "calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha", CAMKA HUGO:CAMK2A HGNC:1460 ENTREZ:815 UNIPROT:Q9UQM7 GENECARDS:CAMK2A REACTOME:57903 KEGG:815 ATLASONC:GC_CAMK2A WIKI:CAMK2A calcium/calmodulin-dependent protein kinase II beta "calcium/calmodulin-dependent protein kinase (CaM kinase) II beta", CAMKB HUGO:CAMK2B HGNC:1461 ENTREZ:816 UNIPROT:Q13554 GENECARDS:CAMK2B REACTOME:57905 KEGG:816 ATLASONC:GC_CAMK2B WIKI:CAMK2B calcium/calmodulin-dependent protein kinase II delta HUGO:CAMK2D HGNC:1462 ENTREZ:817 UNIPROT:Q13557 GENECARDS:CAMK2D REACTOME:57907 KEGG:817 ATLASONC:GC_CAMK2D WIKI:CAMK2D calcium/calmodulin-dependent protein kinase II gamma HUGO:CAMK2G HGNC:1463 ENTREZ:818 UNIPROT:Q13555 GENECARDS:CAMK2G REACTOME:57909 KEGG:818 ATLASONC:GC_CAMK2G WIKI:CAMK2G calcium/calmodulin-dependent protein kinase II beta"calcium/calmodulin-dependent protein kinase (CaM kinase) II beta", CAMKB HUGO:CAMK2B HGNC:1461 ENTREZ:816 UNIPROT:Q13554 GENECARDS:CAMK2B REACTOME:57905 KEGG:816 ATLASONC:GC_CAMK2B WIKI:CAMK2B HUGO:CAMK2D HGNC:1462 ENTREZ:817 UNIPROT:Q13557 GENECARDS:CAMK2D REACTOME:57907 KEGG:817 ATLASONC:GC_CAMK2D WIKI:CAMK2D "calcium/calmodulin-dependent protein kinase (CaM kinase) II delta", CAMKD "calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma", CAMKG Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CAMK2*"/> <bbox w="80.0" h="40.0" x="7748.25" y="789.25"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc1_s121_wnc1_wnc1_sa106"> <label text="Ca2+"/> <bbox w="25.0" h="25.0" x="7776.125" y="831.75"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s1051_wnc1_wnc1_sa726"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: calmodulin 1 (phosphorylase kinase, delta) CALML2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 2 (phosphorylase kinase, delta) HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 3 (phosphorylase kinase, delta) HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Calmodulin*"/> <bbox w="80.0" h="40.0" x="7750.5" y="739.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s130_wnc1_wnc1_csa16" compartmentRef="wnc1_wnc1_c3_wnc1_wnc1_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:IP3:IP3R* Identifiers_end References_begin: Ca2+/Wnt MODULE s_wnc1_re27:(MAP:survival) PMID:12747838 References_end</body> </html> </notes> <label text="IP3:IP3R*"/> <bbox w="102.0" h="103.0" x="7422.0" y="898.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s132_wnc1_wnc1_sa112"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: inositol 1,4,5-trisphosphate receptor, type 1 SCA15, SCA16, "spinocerebellar ataxia 15", "spinocerebellar ataxia 16" HUGO:ITPR1 HGNC:6180 ENTREZ:3708 UNIPROT:Q14643 GENECARDS:ITPR1 REACTOME:405731 KEGG:3708 ATLASONC:GC_ITPR1 WIKI:ITPR1 inositol 1,4,5-trisphosphate receptor, type 2 "inositol 1,4,5-triphosphate receptor, type 2" HUGO:ITPR2 HGNC:6181 ENTREZ:3709 UNIPROT:Q14571 GENECARDS:ITPR2 REACTOME:405722 KEGG:3709 ATLASONC:GC_ITPR2 WIKI:ITPR2 inositol 1,4,5-trisphosphate receptor, type "inositol 1,4,5-triphosphate receptor, type 3" HUGO:ITPR3 HGNC:6182 ENTREZ:3710 UNIPROT:Q14573 GENECARDS:ITPR3 REACTOME:57433 KEGG:3710 ATLASONC:GC_ITPR3 WIKI:ITPR3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="IP3R*"/> <bbox w="80.0" h="50.0" x="7433.5" y="928.0"/> <glyph class="unit of information" id="_1ac4b311-0925-486a-97f4-463566beda16"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7451.0" y="923.0"/> </glyph> </glyph> <glyph class="simple chemical" id="wnc1_wnc1_s131_wnc1_wnc1_sa113"> <label text="IP3"/> <bbox w="70.0" h="25.0" x="7436.5" y="906.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s136_wnc1_wnc1_csa17" compartmentRef="wnc1_wnc1_c3_wnc1_wnc1_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:G_beta_*:G_gamma_*:IP3R* Identifiers_end References_begin: Ca2+/Wnt MODULE s_wnc1_re29:(MAP:survival) PMID:12747838 References_end</body> </html> </notes> <label text="Gβ*:Gγ*:IP3R*"/> <bbox w="101.0" h="104.0" x="7420.0" y="1058.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s137_wnc1_wnc1_sa114"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: inositol 1,4,5-trisphosphate receptor, type 1 SCA15, SCA16, "spinocerebellar ataxia 15", "spinocerebellar ataxia 16" HUGO:ITPR1 HGNC:6180 ENTREZ:3708 UNIPROT:Q14643 GENECARDS:ITPR1 REACTOME:405731 KEGG:3708 ATLASONC:GC_ITPR1 WIKI:ITPR1 inositol 1,4,5-trisphosphate receptor, type 2 "inositol 1,4,5-triphosphate receptor, type 2" HUGO:ITPR2 HGNC:6181 ENTREZ:3709 UNIPROT:Q14571 GENECARDS:ITPR2 REACTOME:405722 KEGG:3709 ATLASONC:GC_ITPR2 WIKI:ITPR2 inositol 1,4,5-trisphosphate receptor, type "inositol 1,4,5-triphosphate receptor, type 3" HUGO:ITPR3 HGNC:6182 ENTREZ:3710 UNIPROT:Q14573 GENECARDS:ITPR3 REACTOME:57433 KEGG:3710 ATLASONC:GC_ITPR3 WIKI:ITPR3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="IP3R*"/> <bbox w="80.0" h="50.0" x="7431.5" y="1065.0"/> <glyph class="unit of information" id="_9919b56a-d701-4afb-a25d-581c553cbbe7"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7449.0" y="1060.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s134_wnc1_wnc1_sa115"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="7469.5" y="1117.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s135_wnc1_wnc1_sa116"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="7430.5" y="1117.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s141_wnc1_wnc1_csa18" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:p101*:p110_beta__gamma_* Identifiers_end</body> </html> </notes> <label text="p101*:p110βγ*"/> <bbox w="100.0" h="120.0" x="7675.0" y="962.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s143_wnc1_wnc1_sa118"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Phosphoinositide-3-kinase, regulatory subunit 5, p101 HUGO:PIK3R5 HGNC:30035 ENTREZ:23533 UNIPROT:Q8WYR1 GENECARDS:PIK3R5 REACTOME:242723 KEGG:23533 ATLASONC:GC_PIK3R5 WIKI:PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:16847462 References_end Identifiers_begin: Phosphoinositide-3-kinase, regulatory subunit 5, p101 HUGO:PIK3R5 HGNC:30035 ENTREZ:23533 UNIPROT:Q8WYR1 GENECARDS:PIK3R5 REACTOME:242723 KEGG:23533 ATLASONC:GC_PIK3R5 WIKI:PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:16847462 References_end</body> </html> </notes> <label text="p101*"/> <bbox w="80.0" h="40.0" x="7684.0" y="971.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s144_wnc1_wnc1_sa119"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta "phosphoinositide-3-kinase, catalytic, beta polypeptide", PIK3C1 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma "phosphoinositide-3-kinase, catalytic, gamma polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:16847462 References_end Identifiers_begin: phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta "phosphoinositide-3-kinase, catalytic, beta polypeptide", PIK3C1 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma "phosphoinositide-3-kinase, catalytic, gamma polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:16847462 References_end</body> </html> </notes> <label text="p110βγ*"/> <bbox w="80.0" h="40.0" x="7684.0" y="1012.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s150_wnc1_wnc1_csa19" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:G_beta_*:G_gamma_*:p101*:p110_beta__gamma_* Identifiers_end</body> </html> </notes> <label text="Gβ*:Gγ*:p101*:p110βγ*"/> <bbox w="99.0" h="152.0" x="7842.5" y="961.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s148_wnc1_wnc1_sa120"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Phosphoinositide-3-kinase, regulatory subunit 5, p101 HUGO:PIK3R5 HGNC:30035 ENTREZ:23533 UNIPROT:Q8WYR1 GENECARDS:PIK3R5 REACTOME:242723 KEGG:23533 ATLASONC:GC_PIK3R5 WIKI:PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:16847462 References_end Identifiers_begin: Phosphoinositide-3-kinase, regulatory subunit 5, p101 HUGO:PIK3R5 HGNC:30035 ENTREZ:23533 UNIPROT:Q8WYR1 GENECARDS:PIK3R5 REACTOME:242723 KEGG:23533 ATLASONC:GC_PIK3R5 WIKI:PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:16847462 References_end</body> </html> </notes> <label text="p101*"/> <bbox w="80.0" h="40.0" x="7851.5" y="970.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s149_wnc1_wnc1_sa121"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta "phosphoinositide-3-kinase, catalytic, beta polypeptide", PIK3C1 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma "phosphoinositide-3-kinase, catalytic, gamma polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:16847462 References_end Identifiers_begin: phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta "phosphoinositide-3-kinase, catalytic, beta polypeptide", PIK3C1 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma "phosphoinositide-3-kinase, catalytic, gamma polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:16847462 References_end</body> </html> </notes> <label text="p110βγ*"/> <bbox w="80.0" h="40.0" x="7851.5" y="1011.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s145_wnc1_wnc1_sa122"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="7852.5" y="1052.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s146_wnc1_wnc1_sa123"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="7892.5" y="1052.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s164_wnc1_wnc1_csa20" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:EGFR:HB-EGF*:HER2* Identifiers_end References_begin: s_wnc1_re37(MAP:survival): PMID:18372913 PAR1 activates EGFR PMID:16525676 References_end</body> </html> </notes> <label text="EGFR:HB-EGF*:HER2*"/> <bbox w="105.0" h="170.0" x="7149.5" y="1505.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s161_wnc1_wnc1_sa134"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>HUGO:EGFR MODULE:GROWTH_FACTORS_LIGANDS_RECEPTORS PMID:20430953 All EGF family members bind to a group of four receptor tyrosine kinases, namely ErbB-1/EGFR through -4 (also called HER1???4). Like other tyrosine kinases, each ErbB molecule comprises an extracellular domain to allow ligand binding, a single transmembrane part, and an intracellular protein tyrosine kinase domain. It is important noting that not all ErbB receptors act autonomously: ErbB-2 (also called HER2 and Neu) binds no known EGF-like ligand (56), and ErbB-3 shows no tyrosine kinase activity (40). PMID:28513565 Epidermal growth factor receptor (EGFR) signaling pathways leading to G1/S cell cycle progression activated by EGF activation. Depicted are the RAS-RAF-MEK-ERK MAPK and PI3K-AKT-mTOR pathways. Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)", ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="EGFR"/> <bbox w="80.0" h="50.0" x="7164.5" y="1560.0"/> <glyph class="unit of information" id="_68320960-2e23-4a10-b64e-d564c851531d"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7182.0" y="1555.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s162_wnc1_wnc1_sa135"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) NGL, "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:ECM MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HER2*"/> <bbox w="80.0" h="50.0" x="7164.5" y="1600.0"/> <glyph class="unit of information" id="_c356d48a-7b1d-4fdd-8d2b-f1448c0bc3fa"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7182.0" y="1595.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s163_wnc1_wnc1_sa136"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: @heparin-binding EGF-like growth factor "diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor)", DTR, DTS, HEGFL HUGO:HBEGF HGNC:3059 ENTREZ:1839 UNIPROT:Q99075 GENECARDS:HBEGF REACTOME:56374 KEGG:1839 ATLASONC:GC_HBEGF WIKI:HBEGF Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HB-EGF*"/> <bbox w="80.0" h="40.0" x="7164.5" y="1515.0"/> <glyph class="unit of information" id="_d7432485-d011-43c8-903c-dead33bff46b"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="7179.5" y="1510.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s172_wnc1_wnc1_csa22" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GDP:G_alpha__sub_s_endsub_*:G_beta_*:G_gamma_* Identifiers_end References_begin: s_wnc1_re46:(MAP:survival) PMID:21406690 s_wnc1_re54:(MAP:survival) PMID:10999941 References_end</body> </html> </notes> <label text="GDP:Gαs*:Gβ*:Gγ*"/> <bbox w="157.625" h="47.375" x="9063.1875" y="426.3125"/> <glyph class="macromolecule" id="wnc1_wnc1_s22_wnc1_wnc1_sa140"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="9123.8125" y="430.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s24_wnc1_wnc1_sa141"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="9164.8125" y="430.0"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc1_s193_wnc1_wnc1_sa157"> <label text="GDP"/> <bbox w="25.0" h="25.0" x="9069.5" y="447.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s205_wnc1_wnc1_sa163"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: GNAS complex locus GNAS1, "guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1" HUGO:GNAS HGNC:4392 ENTREZ:2778 UNIPROT:O95467 GENECARDS:GNAS KEGG:2778 ATLASONC:GNASID40727ch20q13 WIKI:GNAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Gαs*"/> <bbox w="40.0" h="20.0" x="9082.0" y="430.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s233_wnc1_wnc1_csa28" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CCN2*:LRP6 Identifiers_end References_begin: s_wnc1_re47:(MAP:survival) PMID:21237163 References_end</body> </html> </notes> <label text="CCN2*:LRP6"/> <bbox w="100.0" h="100.0" x="9515.0" y="776.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s231_wnc1_wnc1_sa182"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: connective tissue growth factor HUGO:CTGF HGNC:2500 ENTREZ:1490 UNIPROT:P29279 GENECARDS:CTGF REACTOME:53030 KEGG:1490 ATLASONC:CTGFID40192ch6q23 WIKI:CTGF Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CCN2*"/> <bbox w="35.0" h="30.0" x="9552.25" y="781.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s234_wnc1_wnc1_sa183"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LRP6"/> <bbox w="80.0" h="50.0" x="9526.0" y="801.0"/> <glyph class="state variable" id="_b6f39c5c-0b4c-4610-83bf-aca4d0b04234"> <state value="" variable="T1572"/> <bbox w="35.0" h="10.0" x="9508.5" y="820.9602"/> </glyph> <glyph class="state variable" id="_26c68a6b-f95a-4c73-b4ad-83a87408bd03"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="9548.532" y="796.0"/> </glyph> <glyph class="state variable" id="_8941054e-e0fb-489e-9747-f880ab01053c"> <state value="" variable="S1544"/> <bbox w="35.0" h="10.0" x="9588.5" y="796.26843"/> </glyph> <glyph class="state variable" id="_ad07478a-592f-46b2-a145-4744b28347cd"> <state value="" variable="T1548"/> <bbox w="35.0" h="10.0" x="9588.5" y="834.4372"/> </glyph> <glyph class="state variable" id="_76fb06a1-1dc6-42ea-879c-fe817b5ca7ef"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="9588.5" y="796.26843"/> </glyph> <glyph class="state variable" id="_25627680-99ae-476b-ae69-0b4d4ff65c88"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="9508.992" y="796.0"/> </glyph> <glyph class="unit of information" id="_f0f3f41f-3d41-4006-8a59-2eaac19c9b93"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9543.5" y="796.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s240_wnc1_wnc1_csa29" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FZD*:GTP:G_alpha_*:G_beta_*:G_gamma_*:WNT* Identifiers_end References_begin: Ca2+/Wnt MODULE Wnt/PCP MODULE s_wnc1_re49(MAP:survival): PMID:20628572 PMID:12839624 References_end</body> </html> </notes> <label text="FZD*:GTP:Gα*:Gβ*:Gγ*:WNT*"/> <bbox w="150.0" h="110.0" x="9481.0" y="1076.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s241_wnc1_wnc1_sa185"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Wnt5a signalling mediated through Fz3, Fz4, Fz5 and Fz8 in Drosophila cells PMID:21518267 FZD2 activates Wnt/Ca2+ pathway PMID:17684012 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="9521.0" y="1091.0"/> <glyph class="unit of information" id="_31130d8d-f7c5-45e9-baf8-e6c0a07857bd"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9538.5" y="1086.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s236_wnc1_wnc1_sa186"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Wnt5 activates Ca2+ pathway PMID:21903638 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="9541.0" y="1076.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s249_wnc1_wnc1_sa194"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="9540.0" y="1136.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s250_wnc1_wnc1_sa195"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="9581.0" y="1136.0"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc1_s253_wnc1_wnc1_sa198"> <label text="GTP"/> <bbox w="25.0" h="25.0" x="9493.5" y="1148.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s254_wnc1_wnc1_sa199"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 5Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Gα*"/> <bbox w="40.0" h="20.0" x="9499.0" y="1136.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s259_wnc1_wnc1_csa31" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GTP:G_alpha_* Identifiers_end References_begin: Ca2+/Wnt MODULE s_wnc1_re50:(MAP:survival) PMID:20628572 s_wnc1_re64(MAP:survival): For the Fzl receptor, probably same mechanism as for the canonical MODULE. CK1 epsilon is activated upon Wnt-5 stimulation, however, the mechanism is unknown. PMID:17244647 PMID:20215527 s_wnc1_re51(MAP:survival): PMID:20628572 RGS3 and RGS14 are GTP-ase activating proteins for Gi_alpha and Gq_alpha. PMID:10999941 PMID:12534294 References_end</body> </html> </notes> <label text="GTP:Gα*"/> <bbox w="60.0" h="75.0" x="9172.0" y="1145.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s262_wnc1_wnc1_sa201"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 5Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Gα*"/> <bbox w="40.0" h="20.0" x="9182.0" y="1150.0"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc1_s263_wnc1_wnc1_sa203"> <label text="GTP"/> <bbox w="25.0" h="25.0" x="9189.5" y="1167.5"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s264_wnc1_wnc1_csa32" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GDP:G_alpha_* Identifiers_end References_begin: s_wnc1_re51(MAP:survival): PMID:20628572 RGS3 and RGS14 are GTP-ase activating proteins for Gi_alpha and Gq_alpha. PMID:10999941 PMID:12534294 References_end</body> </html> </notes> <label text="GDP:Gα*"/> <bbox w="60.0" h="75.0" x="9172.0" y="1002.5"/> <glyph class="macromolecule" id="wnc1_wnc1_s265_wnc1_wnc1_sa204"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 5Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Gα*"/> <bbox w="40.0" h="20.0" x="9182.0" y="1007.5"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc1_s266_wnc1_wnc1_sa206"> <label text="GDP"/> <bbox w="25.0" h="25.0" x="9189.5" y="1027.5"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s275_wnc1_wnc1_csa33" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:RGS3 Identifiers_end References_begin: s_wnc1_re56(MAP:survival): PMID:20347994 PMID:10862767 References_end</body> </html> </notes> <label text="14-3-3*:RGS3"/> <bbox w="100.0" h="122.0" x="9052.0" y="793.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s277_wnc1_wnc1_sa212"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="9062.0" y="805.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s276_wnc1_wnc1_sa213"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HUGO:RGS3 HGNC:9999 ENTREZ:5998 UNIPROT:P49796 GENECARDS:RGS3 KEGG:5998 ATLASONC:GC_RGS3 WIKI:RGS3 regulator of G-protein signaling 4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12011974 References_end</body> </html> </notes> <label text="RGS3"/> <bbox w="80.0" h="40.0" x="9061.0" y="845.0"/> <glyph class="state variable" id="_6abd516b-09b0-413c-a091-b91f59558c56"> <state value="P" variable="S264"/> <bbox w="35.0" h="10.0" x="9123.5" y="851.77893"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s278_wnc1_wnc1_csa34" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:G_beta_*:G_gamma_*:PLC-_beta_* Identifiers_end References_begin: Ca2+/Wnt MODULE s_wnc1_re57(MAP:survival): PLC-beta_2 and 3 are activated by the beta-and gamma subunit of the G-protein class q PMID:20553968 s_wnc1_re26:(MAP:survival) PMID:16054198 References_end</body> </html> </notes> <label text="Gβ*:Gγ*:PLC-β*"/> <bbox w="95.0" h="95.0" x="7152.0" y="862.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s279_wnc1_wnc1_sa214"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="7156.0" y="918.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s280_wnc1_wnc1_sa215"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="7197.0" y="918.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s282_wnc1_wnc1_sa217"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PLC-beta3 can be activated by G-alpha and G-beta/gamma subunits PMID:15782111 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phospholipase C, beta 1 (phosphoinositide-specific) HUGO:PLCB1 HGNC:15917 ENTREZ:23236 UNIPROT:Q9NQ66 GENECARDS:PLCB1 REACTOME:61694 KEGG:23236 ATLASONC:PLCB1ID41742ch20p12 WIKI:PLCB1 phospholipase C, beta 2 (phosphoinositide-specific) HUGO:PLCB2 HGNC:9055 ENTREZ:5330 UNIPROT:Q00722 GENECARDS:PLCB2 REACTOME:61696 ATLASONC:PLCB2ID41743ch15q15 WIKI:PLCB2 phospholipase C, beta 3 (phosphoinositide-specific) HUGO:PLCB3 HGNC:9056 ENTREZ:5331 UNIPROT:Q01970 GENECARDS:PLCB3 REACTOME:61748 ATLASONC:GC_PLCB3 WIKI:PLCB3 phospholipase C, beta 4 (phosphoinositide-specific) HUGO:PLCB4 HGNC:9059 ENTREZ:5332 UNIPROT:Q15147 GENECARDS:PLCB4 REACTOME:61698 KEGG:5332 ATLASONC:GC_PLCB4 WIKI:PLCB4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PLC-β*"/> <bbox w="80.0" h="40.0" x="7157.0" y="872.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s286_wnc1_wnc1_csa35" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GTP:RAC1 Identifiers_end</body> </html> </notes> <label text="GTP:RAC1"/> <bbox w="100.0" h="100.0" x="7292.0" y="420.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s289_wnc1_wnc1_sa219"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <bbox w="80.0" h="40.0" x="7302.0" y="430.0"/> <glyph class="state variable" id="_351170a6-ae23-455f-bda2-4dcc059cb756"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7297.0" y="445.0"/> </glyph> </glyph> <glyph class="simple chemical" id="wnc1_wnc1_s290_wnc1_wnc1_sa221"> <label text="GTP"/> <bbox w="25.0" h="25.0" x="7329.5" y="477.5"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s288_wnc1_wnc1_csa36" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GTP:PLC-_beta_*:RAC1 Identifiers_end References_begin: s_wnc1_re58(MAP:survival): PMID:16402909 PMID:12657629 s_wnc1_re26:(MAP:survival) PMID:16054198 References_end</body> </html> </notes> <label text="GTP:PLC-β*:RAC1"/> <bbox w="100.0" h="145.0" x="7152.0" y="980.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s283_wnc1_wnc1_sa218"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: phospholipase C, beta 1 (phosphoinositide-specific) HUGO:PLCB1 HGNC:15917 ENTREZ:23236 UNIPROT:Q9NQ66 GENECARDS:PLCB1 REACTOME:61694 KEGG:23236 ATLASONC:PLCB1ID41742ch20p12 WIKI:PLCB1 phospholipase C, beta 2 (phosphoinositide-specific) HUGO:PLCB2 HGNC:9055 ENTREZ:5330 UNIPROT:Q00722 GENECARDS:PLCB2 REACTOME:61696 ATLASONC:PLCB2ID41743ch15q15 WIKI:PLCB2 phospholipase C, beta 3 (phosphoinositide-specific) HUGO:PLCB3 HGNC:9056 ENTREZ:5331 UNIPROT:Q01970 GENECARDS:PLCB3 REACTOME:61748 ATLASONC:GC_PLCB3 WIKI:PLCB3 phospholipase C, beta 4 (phosphoinositide-specific) HUGO:PLCB4 HGNC:9059 ENTREZ:5332 UNIPROT:Q15147 GENECARDS:PLCB4 REACTOME:61698 KEGG:5332 ATLASONC:GC_PLCB4 WIKI:PLCB4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PLC-β*"/> <bbox w="80.0" h="40.0" x="7162.0" y="990.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s284_wnc1_wnc1_sa222"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <bbox w="80.0" h="40.0" x="7162.0" y="1025.0"/> <glyph class="state variable" id="_67c6beb9-9c94-42e7-a31a-a46b154b8fcf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7157.0" y="1040.0"/> </glyph> </glyph> <glyph class="simple chemical" id="wnc1_wnc1_s287_wnc1_wnc1_sa223"> <label text="GTP"/> <bbox w="25.0" h="25.0" x="7189.5" y="1072.5"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s324_wnc1_wnc1_csa39" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK1_epsilon_*:CTHRC1:FZD*:GTP:G_alpha_*:G_beta_*:G_gamma_*:PAR6*:PRICKLE1:PRR*:RACK1*:ROR2:SYN4*:VANGL*:WNT* Identifiers_end References_begin: s_wnc1_re62(MAP:survival): Cthrc1 enhances formation of Wnt-Fzl-Ror2 complex PMID:12839624 PMID:18606138 Syndecan-4 binds to Fzl, Dvl and is required for PCP MODULE. PMID:16604063 PMID:21397842 Vangl-2 forms complex upon binding with Wnt-5 PMID:21316585 ROR2 is associated with Wnt, Fzl and CK1_epsilon PMID:20215527 PPR binds to Fzl in both canonical and non-canonical MODULE PMID:20093472 PMID:21380625 PMID:20579883 s_wnc1_re64(MAP:survival): For the Fzl receptor, probably same mechanism as for the canonical MODULE. CK1 epsilon is activated upon Wnt-5 stimulation, however, the mechanism is unknown. PMID:17244647 References_end</body> </html> </notes> <label text="CK1ε*:CTHRC1:FZD*:GTP:Gα*:Gβ*:Gγ*:PAR6*:PRICKLE1:PRR*:RACK1*:ROR2:SYN4*:VANGL*:WNT*"/> <bbox w="366.0" h="168.0" x="9291.0" y="1580.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s308_wnc1_wnc1_sa238"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Fzl4 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="9464.5" y="1611.5"/> <glyph class="unit of information" id="_c49aad9e-bbc2-4574-8512-5c4d7e730425"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9482.0" y="1606.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s309_wnc1_wnc1_sa239"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ROR2"/> <bbox w="80.0" h="50.0" x="9545.5" y="1611.5"/> <glyph class="state variable" id="_fb0dc919-819e-4c17-94a6-2b83c457be52"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9580.5" y="1656.5"/> </glyph> <glyph class="state variable" id="_27a615c2-06dc-49e4-ab6e-80b8d629c159"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9540.5" y="1606.5"/> </glyph> <glyph class="state variable" id="_6914527a-5bd8-4b46-b6f7-29fb407f6582"> <state value="" variable="S864"/> <bbox w="30.0" h="10.0" x="9610.5" y="1606.7684"/> </glyph> <glyph class="state variable" id="_60d1aba0-cbbb-4131-9ffe-161851c60cd1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9620.5" y="1656.5"/> </glyph> <glyph class="unit of information" id="_2cf7d903-e3bc-4e21-8ae0-c8da1a810d2e"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9563.0" y="1606.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s310_wnc1_wnc1_sa240"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>ClasII: Wnt4,-5a,-5b, and -11 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="9522.5" y="1590.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s311_wnc1_wnc1_sa241"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 5Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Gα*"/> <bbox w="40.0" h="20.0" x="9443.5" y="1663.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s312_wnc1_wnc1_sa242"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="9484.5" y="1663.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s313_wnc1_wnc1_sa243"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="9525.5" y="1663.0"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc1_s316_wnc1_wnc1_sa244"> <label text="GTP"/> <bbox w="25.0" h="25.0" x="9455.5" y="1683.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s323_wnc1_wnc1_sa252"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="9567.5" y="1661.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s376_wnc1_wnc1_sa290"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: collagen triple helix repeat containing 1 HUGO:CTHRC1 HGNC:18831 ENTREZ:115908 UNIPROT:Q96CG8 GENECARDS:CTHRC1 ATLASONC:CTHRC1ID40193ch8q22 WIKI:CTHRC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTHRC1"/> <bbox w="50.0" h="20.0" x="9566.5" y="1594.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s382_wnc1_wnc1_sa296"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end</body> </html> </notes> <label text="SYN4*"/> <bbox w="80.0" h="50.0" x="9381.5" y="1609.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s400_wnc1_wnc1_sa307"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: VANGL planar cell polarity protein 2 "vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila)", "vang-like 2 (van gogh, Drosophila)" HUGO:VANGL2 HGNC:15511 ENTREZ:57216 UNIPROT:Q9ULK5 GENECARDS:VANGL2 KEGG:57216 ATLASONC:GC_VANGL2 WIKI:VANGL2 VANGL planar cell polarity protein 1 "vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila)", "vang-like 1 (van gogh, Drosophila)" HUGO:VANGL1 HGNC:15512 ENTREZ:81839 UNIPROT:Q8TAA9 GENECARDS:VANGL1 KEGG:81839 ATLASONC:GC_VANGL1 WIKI:VANGL1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="VANGL*"/> <bbox w="80.0" h="50.0" x="9299.5" y="1610.0"/> <glyph class="state variable" id="_5185f10b-c4d5-4e83-8a0d-db5b0fd27795"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9374.5" y="1605.0"/> </glyph> <glyph class="state variable" id="_b4249041-cb79-484b-b02e-720a3e83fdba"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9374.5" y="1630.0"/> </glyph> <glyph class="state variable" id="_986673ba-58a7-4b05-a527-e435012aa076"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9294.5" y="1605.0"/> </glyph> <glyph class="state variable" id="_f37a657f-f763-4222-8d79-12cd078535d6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9294.5" y="1630.0"/> </glyph> <glyph class="unit of information" id="_b54d5b32-7d65-4341-a672-ae82540b4b30"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9317.0" y="1605.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s405_wnc1_wnc1_sa316"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 HUGO:GNB2L1 HGNC:4399 ENTREZ:10399 UNIPROT:P63244 GENECARDS:GNB2L1 KEGG:10399 ATLASONC:GNB2L1ID43285ch5q35 WIKI:GNB2L1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RACK1*"/> <bbox w="80.0" h="40.0" x="9297.5" y="1660.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s573_wnc1_wnc1_sa400"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: prickle homolog 1 (Drosophila) "prickle-like 1 (Drosophila)" HUGO:PRICKLE1 HGNC:17019 ENTREZ:144165 UNIPROT:Q96MT3 GENECARDS:PRICKLE1 KEGG:144165 ATLASONC:GC_PRICKLE1 WIKI:PRICKLE1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Prickle is actually associated with membrane References_end</body> </html> </notes> <label text="PRICKLE1"/> <bbox w="80.0" h="40.0" x="9299.5" y="1701.0"/> <glyph class="state variable" id="_3a60b24c-6e54-45cc-9a5b-bc1d43f0448c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9372.0" y="1696.0"/> </glyph> <glyph class="state variable" id="_a7e4cf30-168b-4b6e-af67-2d950e70a1dd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9294.5" y="1696.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s577_wnc1_wnc1_sa404"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: par-6 partitioning defective 6 homolog alpha (C. elegans) "par-6 (partitioning defective 6, C.elegans) homolog alpha" HUGO:PARD6A HGNC:15943 ENTREZ:50855 UNIPROT:Q9NPB6 GENECARDS:PARD6A REACTOME:97684 KEGG:50855 ATLASONC:GC_PARD6A WIKI:PARD6A Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PAR6*"/> <bbox w="80.0" h="40.0" x="9379.5" y="1690.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s910_wnc1_wnc1_sa612"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end</body> </html> </notes> <label text="PRR*"/> <bbox w="80.0" h="40.0" x="9485.5" y="1687.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s329_wnc1_wnc1_csa40" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK1_epsilon_*:CTHRC1:FZD*:PAR6*:PRICKLE1:PRR*:RACK1*:ROR2:SYN4*:VANGL*:WNT* Identifiers_end References_begin: PCP MODULE s_wnc1_re64(MAP:survival): For the Fzl receptor, probably same mechanism as for the canonical MODULE. CK1 epsilon is activated upon Wnt-5 stimulation, however, the mechanism is unknown. PMID:17244647 PMID:20215527 s_wnc1_re66(MAP:survival): Polymerisation of Dvl-proteins is not associated with endosomes or other vesicles. Polymerization of Dvl acts as scaffold for recruiting Rac1 PMID:20457807 References_end</body> </html> </notes> <label text="CK1ε*:CTHRC1:FZD*:PAR6*:PRICKLE1:PRR*:RACK1*:ROR2:SYN4*:VANGL*:WNT*"/> <bbox w="371.0" h="168.0" x="9286.0" y="1833.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s333_wnc1_wnc1_sa247"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Complex formation with Fzl-7 and Ror2 PMID:20457807 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="9457.5" y="1861.5"/> <glyph class="unit of information" id="_52277c44-7a57-4bef-9b07-b51ce0220350"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9475.0" y="1856.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s334_wnc1_wnc1_sa248"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ROR2"/> <bbox w="80.0" h="50.0" x="9538.5" y="1861.5"/> <glyph class="state variable" id="_55045212-a290-4e09-88ce-e700eeffd691"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9573.5" y="1906.5"/> </glyph> <glyph class="state variable" id="_cdd1ee6f-4ef4-45eb-a6ff-e4fb2e8ee8a8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9533.5" y="1856.5"/> </glyph> <glyph class="state variable" id="_cee3ddea-2a81-457c-8d29-e123a2dd9fd3"> <state value="" variable="S864"/> <bbox w="30.0" h="10.0" x="9603.5" y="1856.7684"/> </glyph> <glyph class="state variable" id="_c7e8968e-51ca-4752-9bc5-fb30ef6d63fb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9613.5" y="1906.5"/> </glyph> <glyph class="unit of information" id="_e63ad9fb-4680-4ebb-9f76-b7b59dce9f79"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9556.0" y="1856.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s335_wnc1_wnc1_sa249"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>ClasII: Wnt4,-5a,-5b, and -11 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="9519.5" y="1838.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s336_wnc1_wnc1_sa250"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="9570.0" y="1917.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s377_wnc1_wnc1_sa289"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: collagen triple helix repeat containing 1 HUGO:CTHRC1 HGNC:18831 ENTREZ:115908 UNIPROT:Q96CG8 GENECARDS:CTHRC1 ATLASONC:CTHRC1ID40193ch8q22 WIKI:CTHRC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTHRC1"/> <bbox w="50.0" h="20.0" x="9560.5" y="1842.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s383_wnc1_wnc1_sa295"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end</body> </html> </notes> <label text="SYN4*"/> <bbox w="80.0" h="50.0" x="9375.5" y="1856.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s401_wnc1_wnc1_sa311"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: VANGL planar cell polarity protein 2 "vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila)", "vang-like 2 (van gogh, Drosophila)" HUGO:VANGL2 HGNC:15511 ENTREZ:57216 UNIPROT:Q9ULK5 GENECARDS:VANGL2 KEGG:57216 ATLASONC:GC_VANGL2 WIKI:VANGL2 VANGL planar cell polarity protein 1 "vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila)", "vang-like 1 (van gogh, Drosophila)" HUGO:VANGL1 HGNC:15512 ENTREZ:81839 UNIPROT:Q8TAA9 GENECARDS:VANGL1 KEGG:81839 ATLASONC:GC_VANGL1 WIKI:VANGL1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="VANGL*"/> <bbox w="80.0" h="50.0" x="9294.5" y="1855.0"/> <glyph class="state variable" id="_214b08af-4b00-4e07-94f5-c729ed389da9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9369.5" y="1850.0"/> </glyph> <glyph class="state variable" id="_0d698578-9cd6-4b5b-8f8e-e415e08e412b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9369.5" y="1875.0"/> </glyph> <glyph class="state variable" id="_8ac9a4c6-8469-4650-bd5e-0539970c408d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9289.5" y="1850.0"/> </glyph> <glyph class="state variable" id="_51d71d9f-01d3-47d4-ae37-da87eff2fa4d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9289.5" y="1875.0"/> </glyph> <glyph class="unit of information" id="_e021c06b-4381-4f9d-8116-3219e4434c75"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9312.0" y="1850.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s406_wnc1_wnc1_sa315"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 HUGO:GNB2L1 HGNC:4399 ENTREZ:10399 UNIPROT:P63244 GENECARDS:GNB2L1 KEGG:10399 ATLASONC:GNB2L1ID43285ch5q35 WIKI:GNB2L1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RACK1*"/> <bbox w="80.0" h="40.0" x="9295.5" y="1906.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s574_wnc1_wnc1_sa401"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: prickle homolog 1 (Drosophila) "prickle-like 1 (Drosophila)" HUGO:PRICKLE1 HGNC:17019 ENTREZ:144165 UNIPROT:Q96MT3 GENECARDS:PRICKLE1 KEGG:144165 ATLASONC:GC_PRICKLE1 WIKI:PRICKLE1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Prickle is actually associated with membrane References_end</body> </html> </notes> <label text="PRICKLE1"/> <bbox w="80.0" h="40.0" x="9296.5" y="1950.0"/> <glyph class="state variable" id="_58c9adfb-9d75-4656-8c14-a8831f4ef6d5"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9369.0" y="1945.0"/> </glyph> <glyph class="state variable" id="_b031e2cd-2bba-4338-873f-cc91aeb83e9f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9291.5" y="1945.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s578_wnc1_wnc1_sa405"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: par-6 partitioning defective 6 homolog alpha (C. elegans) "par-6 (partitioning defective 6, C.elegans) homolog alpha" HUGO:PARD6A HGNC:15943 ENTREZ:50855 UNIPROT:Q9NPB6 GENECARDS:PARD6A REACTOME:97684 KEGG:50855 ATLASONC:GC_PARD6A WIKI:PARD6A Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PAR6*"/> <bbox w="80.0" h="40.0" x="9378.5" y="1908.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s911_wnc1_wnc1_sa613"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end</body> </html> </notes> <label text="PRR*"/> <bbox w="80.0" h="40.0" x="9488.5" y="1918.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s337_wnc1_wnc1_csa42" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK1_epsilon_*:CTHRC1:DVL*:FZD*:PAR6*:PRICKLE1:PRR*:RACK1*:ROR2:SYN4*:VANGL*:WNT*:_beta_-Arrestin2* Identifiers_end References_begin: PCP MODULE s_wnc1_re66(MAP:survival): Polymerisation of Dvl-proteins is not associated with endosomes or other vesicles. Polymerization of Dvl acts as scaffold for recruiting Rac1 PMID:20457807 s_wnc1_re86:(MAP:survival) PMID:17030191 s_wnc1_re88(MAP:survival): Smurf associates upon binding of Wnt5 to frizzled PMID:19379695 References_end</body> </html> </notes> <label text="Fzl/ROR/Wnt/CK1ε/Dvl"/> <bbox w="358.0" h="203.0" x="9295.5" y="2068.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s645_wnc1_wnc1_sa258"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Complex formation with Fzl-7 and Ror2 PMID:20457807 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="9463.0" y="2096.5"/> <glyph class="unit of information" id="_9a4b16d0-61c1-4e25-8bf6-3895ed44ed8c"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9480.5" y="2091.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s646_wnc1_wnc1_sa259"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ROR2"/> <bbox w="80.0" h="50.0" x="9544.0" y="2096.5"/> <glyph class="state variable" id="_9817bc38-f61e-44b2-93ba-40eecd08038b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9579.0" y="2141.5"/> </glyph> <glyph class="state variable" id="_67440961-db81-498a-8ebb-6b20f247fe3c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9539.0" y="2091.5"/> </glyph> <glyph class="state variable" id="_524eb0a3-7d87-4824-8b74-7ea18c2552b7"> <state value="" variable="S864"/> <bbox w="30.0" h="10.0" x="9609.0" y="2091.7686"/> </glyph> <glyph class="state variable" id="_d98ab3cb-b97f-4a35-aa44-b3fe759d544d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9619.0" y="2141.5"/> </glyph> <glyph class="unit of information" id="_06425c8d-c4c5-4834-bdaf-52c06d5ec1fc"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9561.5" y="2091.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s647_wnc1_wnc1_sa260"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>ClasII: Wnt4,-5a,-5b, and -11 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="9525.0" y="2073.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s648_wnc1_wnc1_sa261"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="9401.5" y="2146.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s824_wnc1_wnc1_sa262"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="9488.75" y="2194.0"/> <glyph class="state variable" id="_ff3d99e6-465e-4ee5-bd93-d71ac8ef8e96"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9563.75" y="2189.0"/> </glyph> <glyph class="state variable" id="_dfc755c0-47e2-45bc-935d-a52459e023b6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9483.75" y="2189.0"/> </glyph> <glyph class="state variable" id="_f542affb-8ff8-42d6-aa99-e878eaef43b4"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="9553.132" y="2229.0"/> </glyph> <glyph class="state variable" id="_0f71504d-fe45-4914-aa3d-50ac608295bc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9483.75" y="2189.0"/> </glyph> <glyph class="state variable" id="_e50ebffe-8bf7-40da-bd78-c62741f1f612"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9563.75" y="2189.0"/> </glyph> <glyph class="state variable" id="_d4269958-32d6-40f4-b565-5654ce8071ac"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9560.884" y="2189.0"/> </glyph> <glyph class="state variable" id="_4ba5d2c8-e7b0-471f-b377-f6e1e4099c0d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9563.75" y="2229.0"/> </glyph> <glyph class="state variable" id="_46ed1b39-4c99-4667-a54d-900ea77ddf34"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="9473.75" y="2228.7224"/> </glyph> <glyph class="state variable" id="_c94f2cf4-d00c-4102-8cb8-b5abab876089"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9483.75" y="2229.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s824_wnc1_wnc1_sa263"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="9491.75" y="2147.0"/> <glyph class="state variable" id="_6506acb4-65cd-4692-a9ad-3eaf0de5af0a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9566.75" y="2142.0"/> </glyph> <glyph class="state variable" id="_f210430d-59c7-4ca5-a8c8-a09ecdac113d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9486.75" y="2142.0"/> </glyph> <glyph class="state variable" id="_4e7cba7e-4655-44ef-87f7-a8e845777be1"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="9556.132" y="2182.0"/> </glyph> <glyph class="state variable" id="_520b365c-9553-40e8-ac7d-9301f95eba06"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9486.75" y="2142.0"/> </glyph> <glyph class="state variable" id="_37b3f200-fa80-42a3-bf48-f9676ea3114a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9566.75" y="2142.0"/> </glyph> <glyph class="state variable" id="_2864a889-75b0-4697-84b3-8223b0d70cd3"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9563.884" y="2142.0"/> </glyph> <glyph class="state variable" id="_8052b41c-95a1-41f3-a9ed-b250633f106c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9566.75" y="2182.0"/> </glyph> <glyph class="state variable" id="_34d3994c-7913-4df3-ab3a-b5e87f8da805"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="9476.75" y="2181.7224"/> </glyph> <glyph class="state variable" id="_8c00e7c5-e5c1-403b-bd9c-fb5de9f0df65"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9486.75" y="2182.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s650_wnc1_wnc1_sa288"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: collagen triple helix repeat containing 1 HUGO:CTHRC1 HGNC:18831 ENTREZ:115908 UNIPROT:Q96CG8 GENECARDS:CTHRC1 ATLASONC:CTHRC1ID40193ch8q22 WIKI:CTHRC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTHRC1"/> <bbox w="50.0" h="20.0" x="9567.5" y="2072.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s651_wnc1_wnc1_sa294"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end</body> </html> </notes> <label text="SYN4*"/> <bbox w="80.0" h="50.0" x="9380.5" y="2090.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s652_wnc1_wnc1_sa302"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="9403.5" y="2192.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s653_wnc1_wnc1_sa310"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: VANGL planar cell polarity protein 2 "vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila)", "vang-like 2 (van gogh, Drosophila)" HUGO:VANGL2 HGNC:15511 ENTREZ:57216 UNIPROT:Q9ULK5 GENECARDS:VANGL2 KEGG:57216 ATLASONC:GC_VANGL2 WIKI:VANGL2 VANGL planar cell polarity protein 1 "vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila)", "vang-like 1 (van gogh, Drosophila)" HUGO:VANGL1 HGNC:15512 ENTREZ:81839 UNIPROT:Q8TAA9 GENECARDS:VANGL1 KEGG:81839 ATLASONC:GC_VANGL1 WIKI:VANGL1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="VANGL*"/> <bbox w="80.0" h="50.0" x="9299.5" y="2085.0"/> <glyph class="state variable" id="_ef74fa01-266c-4cbc-bf89-bdc74685fe07"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9374.5" y="2080.0"/> </glyph> <glyph class="state variable" id="_6a89e3c8-aa13-4a6a-b029-a0ca3db995c5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9374.5" y="2105.0"/> </glyph> <glyph class="state variable" id="_e51c4efd-56f3-4afa-bf09-1c3ba8540110"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9294.5" y="2080.0"/> </glyph> <glyph class="state variable" id="_5b78c311-b95f-431b-8655-72a4db3065e0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9294.5" y="2105.0"/> </glyph> <glyph class="unit of information" id="_7f94b71a-f2ff-4a59-be33-a690b8a6602f"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9317.0" y="2080.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s654_wnc1_wnc1_sa314"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 HUGO:GNB2L1 HGNC:4399 ENTREZ:10399 UNIPROT:P63244 GENECARDS:GNB2L1 KEGG:10399 ATLASONC:GNB2L1ID43285ch5q35 WIKI:GNB2L1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RACK1*"/> <bbox w="80.0" h="40.0" x="9306.5" y="2138.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s655_wnc1_wnc1_sa402"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: prickle homolog 1 (Drosophila) "prickle-like 1 (Drosophila)" HUGO:PRICKLE1 HGNC:17019 ENTREZ:144165 UNIPROT:Q96MT3 GENECARDS:PRICKLE1 KEGG:144165 ATLASONC:GC_PRICKLE1 WIKI:PRICKLE1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Prickle is actually associated with membrane References_end</body> </html> </notes> <label text="PRICKLE1"/> <bbox w="80.0" h="40.0" x="9308.5" y="2182.0"/> <glyph class="state variable" id="_fda3c626-415d-4158-a728-e57038d9da4a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9381.0" y="2177.0"/> </glyph> <glyph class="state variable" id="_0d0a9542-6b4d-429c-8030-deb4082cd3d7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9303.5" y="2177.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s656_wnc1_wnc1_sa406"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: par-6 partitioning defective 6 homolog alpha (C. elegans) "par-6 (partitioning defective 6, C.elegans) homolog alpha" HUGO:PARD6A HGNC:15943 ENTREZ:50855 UNIPROT:Q9NPB6 GENECARDS:PARD6A REACTOME:97684 KEGG:50855 ATLASONC:GC_PARD6A WIKI:PARD6A Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PAR6*"/> <bbox w="80.0" h="40.0" x="9310.5" y="2222.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s912_wnc1_wnc1_sa614"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end</body> </html> </notes> <label text="PRR*"/> <bbox w="80.0" h="40.0" x="9570.5" y="2148.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s342_wnc1_wnc1_csa43" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC2*:GSK3* Identifiers_end References_begin: s_wnc1_re109(MAP:survival): Polymerised Dvl act as scaffold for recruiting axin. PMID:21078818 GSK3 phosphorylates ROR2 PMID:17986005 References_end</body> </html> </notes> <label text="APC2*:GSK3*"/> <bbox w="100.0" h="120.0" x="8082.0" y="2610.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s341_wnc1_wnc1_sa266"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC2 HGNC:19989 ENTREZ:29882 UNIPROT:Q9UJX6 GENECARDS:ANAPC2 REACTOME:84976 KEGG:29882 ATLASONC:GC_ANAPC2 WIKI:ANAPC2 axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC2 HGNC:19989 ENTREZ:29882 UNIPROT:Q9UJX6 GENECARDS:ANAPC2 REACTOME:84976 KEGG:29882 ATLASONC:GC_ANAPC2 WIKI:ANAPC2 axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="APC2*"/> <bbox w="80.0" h="40.0" x="8091.0" y="2619.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s352_wnc1_wnc1_sa267"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="8091.0" y="2661.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s355_wnc1_wnc1_csa44" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK1_epsilon_*:CTHRC1:DVL*:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2* Identifiers_end References_begin: PCP MODULE s_wnc1_re111(MAP:survival): Rspo is required for clathrin-mediated endocytosis PMID:21397842 It has been shown that Dvl polymers are not associated with vesicles, therefore endocytosis of the complex is likely to be after Dvl polymerisation. PMID:16263762 s_wnc1_re112(MAP:survival): Clathrin-mediated endocytosis PMID:20947020 PMID:19910923 PCP MODULE splits in Rac1 branch when Dvl is not hyper-phosphorylated PMID:18953287 s_wnc1_re114(MAP:survival): RhoA branch of the PCP -MODULE when Dvl is hyper-phosphorylated by CK_epsilon References_end</body> </html> </notes> <label text="Fzl/ROR/Wnt/CK1ε/Dvl/Axin/GSK3"/> <bbox w="397.0" h="214.0" x="8575.5" y="2561.5"/> <glyph class="macromolecule" id="wnc1_wnc1_s898_wnc1_wnc1_sa268"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Complex formation with Fzl-7 and Ror2 PMID:20457807 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="8765.0" y="2586.0"/> <glyph class="unit of information" id="_51d193ca-1e84-4930-898a-17aabdfa0d57"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8782.5" y="2581.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s899_wnc1_wnc1_sa269"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ROR2"/> <bbox w="80.0" h="50.0" x="8846.0" y="2592.0"/> <glyph class="state variable" id="_42c26c82-3bca-427f-8582-8ef6be08def6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8881.0" y="2637.0"/> </glyph> <glyph class="state variable" id="_c9fbf293-d1d7-43e5-9e84-2bbb857b9b31"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8841.0" y="2587.0"/> </glyph> <glyph class="state variable" id="_fe0e100a-adf9-4ace-9b7a-f70487b95f10"> <state value="" variable="S864"/> <bbox w="30.0" h="10.0" x="8911.0" y="2587.2686"/> </glyph> <glyph class="state variable" id="_f3cb886f-14ba-4fab-abd1-9e0d82d96e77"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8921.0" y="2637.0"/> </glyph> <glyph class="unit of information" id="_2adcd9f8-0bf2-4fe3-a69d-bee72209ae5b"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8863.5" y="2587.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s900_wnc1_wnc1_sa270"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>ClasII: Wnt4,-5a,-5b, and -11 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="8761.0" y="2566.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s901_wnc1_wnc1_sa271"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="8666.5" y="2640.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s902_wnc1_wnc1_sa287"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: collagen triple helix repeat containing 1 HUGO:CTHRC1 HGNC:18831 ENTREZ:115908 UNIPROT:Q96CG8 GENECARDS:CTHRC1 ATLASONC:CTHRC1ID40193ch8q22 WIKI:CTHRC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTHRC1"/> <bbox w="50.0" h="20.0" x="8801.5" y="2572.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s903_wnc1_wnc1_sa293"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end</body> </html> </notes> <label text="SYN4*"/> <bbox w="80.0" h="50.0" x="8679.5" y="2586.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s907_wnc1_wnc1_sa301"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="8671.5" y="2686.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s904_wnc1_wnc1_sa309"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: VANGL planar cell polarity protein 2 "vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila)", "vang-like 2 (van gogh, Drosophila)" HUGO:VANGL2 HGNC:15511 ENTREZ:57216 UNIPROT:Q9ULK5 GENECARDS:VANGL2 KEGG:57216 ATLASONC:GC_VANGL2 WIKI:VANGL2 VANGL planar cell polarity protein 1 "vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila)", "vang-like 1 (van gogh, Drosophila)" HUGO:VANGL1 HGNC:15512 ENTREZ:81839 UNIPROT:Q8TAA9 GENECARDS:VANGL1 KEGG:81839 ATLASONC:GC_VANGL1 WIKI:VANGL1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="VANGL*"/> <bbox w="80.0" h="50.0" x="8596.5" y="2585.0"/> <glyph class="state variable" id="_a1e1b2f7-c1ab-495f-942e-15cf551d15e2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8671.5" y="2580.0"/> </glyph> <glyph class="state variable" id="_4f2c2690-83f7-4071-9264-5225d99a57fd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8671.5" y="2605.0"/> </glyph> <glyph class="state variable" id="_aca71898-af8d-4385-a2a7-6a56802309fb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8591.5" y="2580.0"/> </glyph> <glyph class="state variable" id="_02d85f82-382c-4e5c-99b7-7700ae2f3226"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8591.5" y="2605.0"/> </glyph> <glyph class="unit of information" id="_dcbe5703-5124-4ec6-ac32-de6759cb453f"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8614.0" y="2580.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s905_wnc1_wnc1_sa313"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 HUGO:GNB2L1 HGNC:4399 ENTREZ:10399 UNIPROT:P63244 GENECARDS:GNB2L1 KEGG:10399 ATLASONC:GNB2L1ID43285ch5q35 WIKI:GNB2L1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RACK1*"/> <bbox w="80.0" h="40.0" x="8583.5" y="2639.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s906_wnc1_wnc1_sa407"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: par-6 partitioning defective 6 homolog alpha (C. elegans) "par-6 (partitioning defective 6, C.elegans) homolog alpha" HUGO:PARD6A HGNC:15943 ENTREZ:50855 UNIPROT:Q9NPB6 GENECARDS:PARD6A REACTOME:97684 KEGG:50855 ATLASONC:GC_PARD6A WIKI:PARD6A Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PAR6*"/> <bbox w="80.0" h="40.0" x="8584.5" y="2689.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s863_wnc1_wnc1_sa578"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="8758.25" y="2640.5"/> <glyph class="state variable" id="_c9c845ed-0b53-4ded-9008-38826826604a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8833.25" y="2635.5"/> </glyph> <glyph class="state variable" id="_d9765c55-bcd7-4785-9471-f78bb4b082f9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8753.25" y="2635.5"/> </glyph> <glyph class="state variable" id="_1dbb8688-8dd9-42f0-83a5-18d78d86eff8"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="8822.632" y="2675.5"/> </glyph> <glyph class="state variable" id="_fdb590a8-3c18-4fc0-89de-397e72bfb027"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8753.25" y="2635.5"/> </glyph> <glyph class="state variable" id="_a6d3c070-b0c7-4dbd-b2db-69d561de6c8c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8833.25" y="2635.5"/> </glyph> <glyph class="state variable" id="_852010f6-0f23-4bc1-9f5c-84991363a866"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8830.384" y="2635.5"/> </glyph> <glyph class="state variable" id="_cd193047-891c-4d6e-9669-a70d286ed563"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8833.25" y="2675.5"/> </glyph> <glyph class="state variable" id="_1b349fd4-054e-44ef-8c9a-a1fe395634eb"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="8743.25" y="2675.2224"/> </glyph> <glyph class="state variable" id="_91098601-83d7-4db0-a690-8ee57f1b4789"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8753.25" y="2675.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s863_wnc1_wnc1_sa579"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="8758.25" y="2687.5"/> <glyph class="state variable" id="_9c87b2d1-4974-4d3f-8d77-9cac49efefda"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8833.25" y="2682.5"/> </glyph> <glyph class="state variable" id="_daa6c321-89d2-46ed-80c6-d6391a670fcb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8753.25" y="2682.5"/> </glyph> <glyph class="state variable" id="_a80b626e-76fc-4958-83ce-886894223714"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="8822.632" y="2722.5"/> </glyph> <glyph class="state variable" id="_d030695d-1756-434a-bf9d-d59904f76035"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8753.25" y="2682.5"/> </glyph> <glyph class="state variable" id="_8c8be6db-d62d-42bf-a92d-b19ab3a26450"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8833.25" y="2682.5"/> </glyph> <glyph class="state variable" id="_b2f0be27-5901-4e6d-b7a0-dd41bd3be9e6"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8830.384" y="2682.5"/> </glyph> <glyph class="state variable" id="_9b7ec97b-2208-464f-9082-5b84d6876dfb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8833.25" y="2722.5"/> </glyph> <glyph class="state variable" id="_1bde5f72-f446-483e-87ca-26cfa33215e1"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="8743.25" y="2722.2224"/> </glyph> <glyph class="state variable" id="_2967edbb-4475-4b39-8892-5633b2b5b789"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8753.25" y="2722.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s908_wnc1_wnc1_sa593"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: R-spondin 3 "R-spondin 3 homolog (Xenopus laevis)", "thrombospondin, type I, domain containing 2", THSD2 HUGO:RSPO3 HGNC:20866 ENTREZ:84870 UNIPROT:Q9BXY4 GENECARDS:RSPO3 KEGG:84870 ATLASONC:GC_RSPO3 WIKI:RSPO3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RSPO3"/> <bbox w="50.0" h="40.0" x="8847.5" y="2686.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s915_wnc1_wnc1_sa617"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end</body> </html> </notes> <label text="PRR*"/> <bbox w="80.0" h="40.0" x="8847.5" y="2642.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s366_wnc1_wnc1_csa45" compartmentRef="wnc1_wnc1_c7_wnc1_wnc1_ca9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC2*:CK1_epsilon_*:CTHRC1:DVL*:FZD*:GSK3*:PAR6*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2* Identifiers_end References_begin: PCP MODULE s_wnc1_re109(MAP:survival): Polymerised Dvl act as scaffold for recruiting axin. PMID:21078818 GSK3 phosphorylates ROR2 PMID:17986005 s_wnc1_re69(MAP:survival): PMID:21069266 PMID:15388793 s_wnc1_re76(MAP:survival): PMID:15375164 References_end</body> </html> </notes> <label text="Fzl/ROR/Wnt/CK1ε/Dvl/Axin/GSK3"/> <bbox w="379.0" h="234.0" x="7730.75" y="2369.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s415_wnc1_wnc1_sa277"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Complex formation with Fzl-7 and Ror2 PMID:20457807 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="7930.25" y="2424.5"/> <glyph class="unit of information" id="_1ce45129-f775-448c-9662-f8d15d001bc9"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7947.75" y="2419.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s416_wnc1_wnc1_sa278"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ROR2"/> <bbox w="80.0" h="50.0" x="8018.25" y="2428.5"/> <glyph class="state variable" id="_1e617ba6-2f20-452b-a69d-dc409feed509"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8053.25" y="2473.5"/> </glyph> <glyph class="state variable" id="_3398462c-c788-4552-8afc-5d8dca2f8c4a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8013.25" y="2423.5"/> </glyph> <glyph class="state variable" id="_13da5bd1-aae2-4e31-a572-d7b325a9e365"> <state value="P" variable="S864"/> <bbox w="35.0" h="10.0" x="8080.75" y="2423.7686"/> </glyph> <glyph class="state variable" id="_76dc4f8b-6892-49b4-b1c3-70d612771f55"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8093.25" y="2473.5"/> </glyph> <glyph class="unit of information" id="_c0c84a65-1d08-41df-997d-86f2eebdd1f5"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8035.75" y="2423.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s417_wnc1_wnc1_sa279"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>ClasII: Wnt4,-5a,-5b, and -11 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="7919.25" y="2409.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s418_wnc1_wnc1_sa280"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="7852.75" y="2481.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s370_wnc1_wnc1_sa281"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="7937.0" y="2485.0"/> <glyph class="state variable" id="_312a1df6-0955-4b30-85a7-930f73b924f2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8012.0" y="2480.0"/> </glyph> <glyph class="state variable" id="_22b0dfb9-14e6-415a-8dd1-0068b373f8d0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7932.0" y="2480.0"/> </glyph> <glyph class="state variable" id="_6bf7b059-f95b-4e8c-83ba-7c122aa0a089"> <state value="P" variable="S139"/> <bbox w="35.0" h="10.0" x="7998.882" y="2520.0"/> </glyph> <glyph class="state variable" id="_dde7ddc9-ac64-4288-a429-fd990bc5a951"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7932.0" y="2480.0"/> </glyph> <glyph class="state variable" id="_6bde2a4e-825f-4a67-83fa-dd6e67e0af62"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8012.0" y="2480.0"/> </glyph> <glyph class="state variable" id="_8a2bb631-ef71-4183-bb2e-04d2d18c8618"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8009.1333" y="2480.0"/> </glyph> <glyph class="state variable" id="_200bd5f1-702b-4172-b4c1-5f63aa761a45"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8012.0" y="2520.0"/> </glyph> <glyph class="state variable" id="_b076ba0a-37ea-4119-a5fd-bb85ab9771e3"> <state value="P" variable="S142"/> <bbox w="35.0" h="10.0" x="7919.5" y="2519.7224"/> </glyph> <glyph class="state variable" id="_ba3afdb4-7514-445c-922b-ec15d84e2430"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7932.0" y="2520.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s370_wnc1_wnc1_sa282"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="7933.0" y="2526.0"/> <glyph class="state variable" id="_a651065a-8d53-4328-9f83-56ac8243ead6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8008.0" y="2521.0"/> </glyph> <glyph class="state variable" id="_f34ddcde-a029-4e55-a6ff-27ecbb345866"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7928.0" y="2521.0"/> </glyph> <glyph class="state variable" id="_68686779-07ea-4493-94af-11d9989349a1"> <state value="P" variable="S139"/> <bbox w="35.0" h="10.0" x="7994.882" y="2561.0"/> </glyph> <glyph class="state variable" id="_2aa75a87-ebeb-4017-870a-52241660807c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7928.0" y="2521.0"/> </glyph> <glyph class="state variable" id="_db80bb66-45f5-42a8-b572-b2b339571ab8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8008.0" y="2521.0"/> </glyph> <glyph class="state variable" id="_2815d5bc-a05a-45e0-8110-6d62f5a80941"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8005.1333" y="2521.0"/> </glyph> <glyph class="state variable" id="_6cd6f6e9-8365-40ae-8038-80b17213c9dd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8008.0" y="2561.0"/> </glyph> <glyph class="state variable" id="_956486e8-0bfd-44c5-b9a6-62088386c958"> <state value="P" variable="S142"/> <bbox w="35.0" h="10.0" x="7915.5" y="2560.7224"/> </glyph> <glyph class="state variable" id="_d4ffe60f-646a-4479-8d63-981b346df734"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7928.0" y="2561.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s420_wnc1_wnc1_sa284"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC2 HGNC:19989 ENTREZ:29882 UNIPROT:Q9UJX6 GENECARDS:ANAPC2 REACTOME:84976 KEGG:29882 ATLASONC:GC_ANAPC2 WIKI:ANAPC2 axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC2 HGNC:19989 ENTREZ:29882 UNIPROT:Q9UJX6 GENECARDS:ANAPC2 REACTOME:84976 KEGG:29882 ATLASONC:GC_ANAPC2 WIKI:ANAPC2 axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="APC2*"/> <bbox w="80.0" h="40.0" x="8018.75" y="2488.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s421_wnc1_wnc1_sa285"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="8018.75" y="2530.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s422_wnc1_wnc1_sa286"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: collagen triple helix repeat containing 1 HUGO:CTHRC1 HGNC:18831 ENTREZ:115908 UNIPROT:Q96CG8 GENECARDS:CTHRC1 ATLASONC:CTHRC1ID40193ch8q22 WIKI:CTHRC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTHRC1"/> <bbox w="50.0" h="20.0" x="7962.5" y="2410.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s423_wnc1_wnc1_sa292"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end</body> </html> </notes> <label text="SYN4*"/> <bbox w="80.0" h="50.0" x="7846.5" y="2424.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s424_wnc1_wnc1_sa300"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="7850.5" y="2531.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s425_wnc1_wnc1_sa308"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: VANGL planar cell polarity protein 2 "vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila)", "vang-like 2 (van gogh, Drosophila)" HUGO:VANGL2 HGNC:15511 ENTREZ:57216 UNIPROT:Q9ULK5 GENECARDS:VANGL2 KEGG:57216 ATLASONC:GC_VANGL2 WIKI:VANGL2 VANGL planar cell polarity protein 1 "vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila)", "vang-like 1 (van gogh, Drosophila)" HUGO:VANGL1 HGNC:15512 ENTREZ:81839 UNIPROT:Q8TAA9 GENECARDS:VANGL1 KEGG:81839 ATLASONC:GC_VANGL1 WIKI:VANGL1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="VANGL*"/> <bbox w="80.0" h="50.0" x="7762.5" y="2425.0"/> <glyph class="state variable" id="_349f665e-861a-46fa-86b3-9b23b0db8a7c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7837.5" y="2420.0"/> </glyph> <glyph class="state variable" id="_18606fd2-4cc0-4243-9a6b-bfe9852aee20"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7837.5" y="2445.0"/> </glyph> <glyph class="state variable" id="_1aa06aa1-a471-486b-9ec2-689ff8a1aa00"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7757.5" y="2420.0"/> </glyph> <glyph class="state variable" id="_56505201-4d98-4a5b-9f30-0dd98129121e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7757.5" y="2445.0"/> </glyph> <glyph class="unit of information" id="_1b37eccb-16f3-4ebb-86cd-f4f1947f4950"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7780.0" y="2420.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s426_wnc1_wnc1_sa312"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 HUGO:GNB2L1 HGNC:4399 ENTREZ:10399 UNIPROT:P63244 GENECARDS:GNB2L1 KEGG:10399 ATLASONC:GNB2L1ID43285ch5q35 WIKI:GNB2L1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RACK1*"/> <bbox w="80.0" h="40.0" x="7768.5" y="2481.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s581_wnc1_wnc1_sa408"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: par-6 partitioning defective 6 homolog alpha (C. elegans) "par-6 (partitioning defective 6, C.elegans) homolog alpha" HUGO:PARD6A HGNC:15943 ENTREZ:50855 UNIPROT:Q9NPB6 GENECARDS:PARD6A REACTOME:97684 KEGG:50855 ATLASONC:GC_PARD6A WIKI:PARD6A Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PAR6*"/> <bbox w="80.0" h="40.0" x="7768.5" y="2532.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s957_wnc1_wnc1_sa661"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: R-spondin 3 "R-spondin 3 homolog (Xenopus laevis)", "thrombospondin, type I, domain containing 2", THSD2 HUGO:RSPO3 HGNC:20866 ENTREZ:84870 UNIPROT:Q9BXY4 GENECARDS:RSPO3 KEGG:84870 ATLASONC:GC_RSPO3 WIKI:RSPO3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RSPO3"/> <bbox w="50.0" h="40.0" x="7739.5" y="2549.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s1092_wnc1_sa1008"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end</body> </html> </notes> <label text="PRR*"/> <bbox w="80.0" h="40.0" x="8016.0" y="2377.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s387_wnc1_wnc1_csa46" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DVL*:_beta_-Arrestin2* Identifiers_end References_begin: s_wnc1_re70:(MAP:survival) PMID:12958364 s_wnc1_re66(MAP:survival): Polymerisation of Dvl-proteins is not associated with endosomes or other vesicles. Polymerization of Dvl acts as scaffold for recruiting Rac1 PMID:20457807 References_end</body> </html> </notes> <label text="DVL*:β-Arrestin2*"/> <bbox w="100.0" h="120.0" x="9103.0" y="2023.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s820_wnc1_wnc1_sa298"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="9111.75" y="2039.0"/> <glyph class="state variable" id="_3db49380-a076-4970-8e7f-7da4fcffe2de"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9186.75" y="2034.0"/> </glyph> <glyph class="state variable" id="_30f2c137-223b-4d95-83f8-17f44ee189ef"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9106.75" y="2034.0"/> </glyph> <glyph class="state variable" id="_9df5751f-7054-4c30-8e99-568234ee4748"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="9176.132" y="2074.0"/> </glyph> <glyph class="state variable" id="_82ff43d9-bb66-48f4-b0c3-d1a07e6892f6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9106.75" y="2034.0"/> </glyph> <glyph class="state variable" id="_5e9db555-2194-46ff-ab28-86e1baa06091"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9186.75" y="2034.0"/> </glyph> <glyph class="state variable" id="_001fed29-48cc-4222-89bf-394049bb2392"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9183.884" y="2034.0"/> </glyph> <glyph class="state variable" id="_6675cbf9-6600-4fd0-8aa3-3b08c91b1ef8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9186.75" y="2074.0"/> </glyph> <glyph class="state variable" id="_84f9667b-f7e7-4a68-8038-3d9ad5f8818f"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="9096.75" y="2073.7224"/> </glyph> <glyph class="state variable" id="_535a1aee-8f34-48b6-b087-0b2fbe957cb6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9106.75" y="2074.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s388_wnc1_wnc1_sa299"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="9112.5" y="2082.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s396_wnc1_wnc1_csa47" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:RACK1*:VANGL* Identifiers_end References_begin: PMID:21262816 s_wnc1_re72(MAP:survival): Rack1 inhibits canonical MODULE PMID:2126816 s_wnc1_re75:(MAP:survival) PMID:19577357 s_wnc1_re85(MAP:survival): Prickle interacts physically with Vangl PMID:22037766 PMID:12941693 Par6 is constitutively associated with Dvl PMID:19379695 References_end</body> </html> </notes> <label text="RACK1*:VANGL*"/> <bbox w="100.0" h="120.0" x="8847.0" y="1279.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s394_wnc1_wnc1_sa304"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: VANGL planar cell polarity protein 2 "vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila)", "vang-like 2 (van gogh, Drosophila)" HUGO:VANGL2 HGNC:15511 ENTREZ:57216 UNIPROT:Q9ULK5 GENECARDS:VANGL2 KEGG:57216 ATLASONC:GC_VANGL2 WIKI:VANGL2 VANGL planar cell polarity protein 1 "vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila)", "vang-like 1 (van gogh, Drosophila)" HUGO:VANGL1 HGNC:15512 ENTREZ:81839 UNIPROT:Q8TAA9 GENECARDS:VANGL1 KEGG:81839 ATLASONC:GC_VANGL1 WIKI:VANGL1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="VANGL*"/> <bbox w="80.0" h="50.0" x="8852.5" y="1289.0"/> <glyph class="state variable" id="_8e1c9afd-9630-4296-bd27-64a9366a848c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8927.5" y="1284.0"/> </glyph> <glyph class="state variable" id="_5a36b6ca-7f92-467b-99f8-68efd5d94c54"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8927.5" y="1309.0"/> </glyph> <glyph class="state variable" id="_e511eb04-f019-493e-b558-cd38444dc30b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8847.5" y="1284.0"/> </glyph> <glyph class="state variable" id="_fce18258-db62-4344-b2ee-fdb0776f6e9d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8847.5" y="1309.0"/> </glyph> <glyph class="unit of information" id="_b0b11f8e-8d3c-4b28-9cd7-3314fb59f4a2"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8870.0" y="1284.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s397_wnc1_wnc1_sa305"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 HUGO:GNB2L1 HGNC:4399 ENTREZ:10399 UNIPROT:P63244 GENECARDS:GNB2L1 KEGG:10399 ATLASONC:GNB2L1ID43285ch5q35 WIKI:GNB2L1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RACK1*"/> <bbox w="80.0" h="40.0" x="8853.0" y="1341.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s398_wnc1_wnc1_csa48" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PAR6*:PRICKLE1:RACK1*:VANGL* Identifiers_end References_begin: s_wnc1_re85(MAP:survival): Prickle interacts physically with Vangl PMID:22037766 PMID:12941693 Par6 is constitutively associated with Dvl PMID:19379695 s_wnc1_re62(MAP:survival): Cthrc1 enhances formation of Wnt-Fzl-Ror2 complex PMID:12839624 PMID:18606138 Syndecan-4 binds to Fzl, Dvl and is required for PCP MODULE. PMID:16604063 PMID:21397842 Vangl-2 forms complex upon binding with Wnt-5 PMID:21316585 ROR2 is associated with Wnt, Fzl and CK1_epsilon PMID:20215527 PPR binds to Fzl in both canonical and non-canonical MODULE PMID:20093472 PMID:21380625 PMID:20579883 References_end</body> </html> </notes> <label text="PAR6*:PRICKLE1:RACK1*:VANGL*"/> <bbox w="256.0" h="117.0" x="9397.0" y="1200.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s393_wnc1_wnc1_sa303"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: VANGL planar cell polarity protein 2 "vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila)", "vang-like 2 (van gogh, Drosophila)" HUGO:VANGL2 HGNC:15511 ENTREZ:57216 UNIPROT:Q9ULK5 GENECARDS:VANGL2 KEGG:57216 ATLASONC:GC_VANGL2 WIKI:VANGL2 VANGL planar cell polarity protein 1 "vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila)", "vang-like 1 (van gogh, Drosophila)" HUGO:VANGL1 HGNC:15512 ENTREZ:81839 UNIPROT:Q8TAA9 GENECARDS:VANGL1 KEGG:81839 ATLASONC:GC_VANGL1 WIKI:VANGL1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="VANGL*"/> <bbox w="80.0" h="50.0" x="9563.0" y="1212.0"/> <glyph class="state variable" id="_e9f50512-e6dc-4ffd-b15d-0908d19133c1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9638.0" y="1207.0"/> </glyph> <glyph class="state variable" id="_a95ffa24-5690-4ce7-a4af-81d717ccfa32"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9638.0" y="1232.0"/> </glyph> <glyph class="state variable" id="_b201f741-2377-4f55-9689-29c4e8dee031"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9558.0" y="1207.0"/> </glyph> <glyph class="state variable" id="_17bf6366-e98d-4edb-9b54-c849e9ded22a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9558.0" y="1232.0"/> </glyph> <glyph class="unit of information" id="_151851ec-ca73-4ad4-bf65-227f811656d1"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9580.5" y="1207.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s395_wnc1_wnc1_sa306"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 HUGO:GNB2L1 HGNC:4399 ENTREZ:10399 UNIPROT:P63244 GENECARDS:GNB2L1 KEGG:10399 ATLASONC:GNB2L1ID43285ch5q35 WIKI:GNB2L1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RACK1*"/> <bbox w="80.0" h="40.0" x="9481.5" y="1212.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s572_wnc1_wnc1_sa399"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: prickle homolog 1 (Drosophila) "prickle-like 1 (Drosophila)" HUGO:PRICKLE1 HGNC:17019 ENTREZ:144165 UNIPROT:Q96MT3 GENECARDS:PRICKLE1 KEGG:144165 ATLASONC:GC_PRICKLE1 WIKI:PRICKLE1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Prickle is actually associated with membrane References_end</body> </html> </notes> <label text="PRICKLE1"/> <bbox w="80.0" h="40.0" x="9400.5" y="1211.0"/> <glyph class="state variable" id="_ac10cbe3-527c-4e03-8b70-e0fadde612ea"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9473.0" y="1206.0"/> </glyph> <glyph class="state variable" id="_51e41eca-5bb7-4112-b00c-bc7bbb312ea8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9395.5" y="1206.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s576_wnc1_wnc1_sa403"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: par-6 partitioning defective 6 homolog alpha (C. elegans) "par-6 (partitioning defective 6, C.elegans) homolog alpha" HUGO:PARD6A HGNC:15943 ENTREZ:50855 UNIPROT:Q9NPB6 GENECARDS:PARD6A REACTOME:97684 KEGG:50855 ATLASONC:GC_PARD6A WIKI:PARD6A Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PAR6*"/> <bbox w="80.0" h="40.0" x="9400.0" y="1256.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s427_wnc1_wnc1_csa49" compartmentRef="wnc1_wnc1_c7_wnc1_wnc1_ca9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC2*:CK1_epsilon_*:CTHRC1:DVL*:FZD*:GSK3*:PAR6*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2* Identifiers_end References_begin: PCP MODULE s_wnc1_re76(MAP:survival): PMID:21078818 PMID:15375164 s_wnc1_re77(MAP:survival): CK1 delta phosphorylates residues in cluster I: S84, S82, S79, T71 and in cluster II: S5, S8, S11, S14, S17, S20. Note: Experiments were performed in Xenopus PMID:21316585 References_end</body> </html> </notes> <label text="Fzl/ROR/Wnt/CK1ε/Dvl/Axin/GSK3"/> <bbox w="384.0" h="202.0" x="7307.5" y="2402.5"/> <glyph class="macromolecule" id="wnc1_wnc1_s443_wnc1_wnc1_sa321"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Complex formation with Fzl-7 and Ror2 PMID:20457807 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="7508.0" y="2430.0"/> <glyph class="unit of information" id="_a30e703e-162b-48c2-9b56-b832f1373d61"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7525.5" y="2425.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s454_wnc1_wnc1_sa322"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ROR2"/> <bbox w="80.0" h="50.0" x="7592.0" y="2434.0"/> <glyph class="state variable" id="_ff3dfbe7-51cb-4cf0-bfb5-ed87060796ee"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7624.5" y="2479.0"/> </glyph> <glyph class="state variable" id="_5538f4e4-ce03-4900-a87f-58c621bb0120"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7587.0" y="2429.0"/> </glyph> <glyph class="state variable" id="_996fc040-d0ff-4aba-b135-bccd2bf05452"> <state value="P" variable="S864"/> <bbox w="35.0" h="10.0" x="7654.5" y="2429.2686"/> </glyph> <glyph class="state variable" id="_57527b7a-faf3-4501-9be9-17123db7d4aa"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7664.5" y="2479.0"/> </glyph> <glyph class="unit of information" id="_18391f3c-c8ff-4d27-b875-9d001adda0bc"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7609.5" y="2429.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s444_wnc1_wnc1_sa323"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>ClasII: Wnt4,-5a,-5b, and -11 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="7496.0" y="2407.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s445_wnc1_wnc1_sa324"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="7401.5" y="2481.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s431_wnc1_wnc1_sa325"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="7498.75" y="2479.5"/> <glyph class="state variable" id="_af97a4a0-8f74-4fd7-8235-065c8bd8452e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7573.75" y="2474.5"/> </glyph> <glyph class="state variable" id="_a78bb471-5b24-43a2-bf16-eab666363c6c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7493.75" y="2474.5"/> </glyph> <glyph class="state variable" id="_93354c70-3971-4c12-b39d-44f21271fe1c"> <state value="P" variable="S139"/> <bbox w="35.0" h="10.0" x="7560.632" y="2514.5"/> </glyph> <glyph class="state variable" id="_532b71c3-1fe8-4241-b8e2-4a9f1733c571"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7493.75" y="2474.5"/> </glyph> <glyph class="state variable" id="_cacce110-1126-4e9e-9d6d-cbef9728e36d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7573.75" y="2474.5"/> </glyph> <glyph class="state variable" id="_deb07275-597c-4437-87dd-bc971bac5547"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7570.8833" y="2474.5"/> </glyph> <glyph class="state variable" id="_7d217691-db5d-40c8-b89e-1fb6b943309a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7573.75" y="2514.5"/> </glyph> <glyph class="state variable" id="_6d98253e-cf94-4c28-80f7-6b3a80035813"> <state value="P" variable="S142"/> <bbox w="35.0" h="10.0" x="7481.25" y="2514.2224"/> </glyph> <glyph class="state variable" id="_4804e15f-efd0-45d6-9c1b-41a7fc810649"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7493.75" y="2514.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s431_wnc1_wnc1_sa326"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="7496.75" y="2525.5"/> <glyph class="state variable" id="_ec3fbc9e-e5ef-45df-848a-f2fc7b8ed74b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7571.75" y="2520.5"/> </glyph> <glyph class="state variable" id="_a335ff11-3abd-4140-a70a-42ace3aacf7d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7491.75" y="2520.5"/> </glyph> <glyph class="state variable" id="_d76a1ac0-affa-442e-b9ac-d9e6ccb3865f"> <state value="P" variable="S139"/> <bbox w="35.0" h="10.0" x="7558.632" y="2560.5"/> </glyph> <glyph class="state variable" id="_4a55737f-6b21-4933-87d0-4539c814692d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7491.75" y="2520.5"/> </glyph> <glyph class="state variable" id="_e839ef4a-6d38-4f05-b77b-3d59b21e0628"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7571.75" y="2520.5"/> </glyph> <glyph class="state variable" id="_687729d0-35ef-4e71-ace2-44d3001d4db0"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7568.8833" y="2520.5"/> </glyph> <glyph class="state variable" id="_ca9b53b6-a434-4dfe-8132-67ea18999541"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7571.75" y="2560.5"/> </glyph> <glyph class="state variable" id="_9cf9e117-d896-4db5-9538-067d693ce477"> <state value="P" variable="S142"/> <bbox w="35.0" h="10.0" x="7479.25" y="2560.2224"/> </glyph> <glyph class="state variable" id="_f31876e9-e5cd-4cfe-a3b1-3bc85bdb3650"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7491.75" y="2560.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s447_wnc1_wnc1_sa328"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC2 HGNC:19989 ENTREZ:29882 UNIPROT:Q9UJX6 GENECARDS:ANAPC2 REACTOME:84976 KEGG:29882 ATLASONC:GC_ANAPC2 WIKI:ANAPC2 axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC2 HGNC:19989 ENTREZ:29882 UNIPROT:Q9UJX6 GENECARDS:ANAPC2 REACTOME:84976 KEGG:29882 ATLASONC:GC_ANAPC2 WIKI:ANAPC2 axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="APC2*"/> <bbox w="80.0" h="40.0" x="7595.5" y="2487.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s448_wnc1_wnc1_sa329"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="7595.5" y="2529.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s449_wnc1_wnc1_sa330"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: collagen triple helix repeat containing 1 HUGO:CTHRC1 HGNC:18831 ENTREZ:115908 UNIPROT:Q96CG8 GENECARDS:CTHRC1 ATLASONC:CTHRC1ID40193ch8q22 WIKI:CTHRC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTHRC1"/> <bbox w="50.0" h="20.0" x="7539.25" y="2408.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s450_wnc1_wnc1_sa331"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end</body> </html> </notes> <label text="SYN4*"/> <bbox w="80.0" h="50.0" x="7410.25" y="2423.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s451_wnc1_wnc1_sa332"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="7401.25" y="2532.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s452_wnc1_wnc1_sa333"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: VANGL planar cell polarity protein 2 "vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila)", "vang-like 2 (van gogh, Drosophila)" HUGO:VANGL2 HGNC:15511 ENTREZ:57216 UNIPROT:Q9ULK5 GENECARDS:VANGL2 KEGG:57216 ATLASONC:GC_VANGL2 WIKI:VANGL2 VANGL planar cell polarity protein 1 "vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila)", "vang-like 1 (van gogh, Drosophila)" HUGO:VANGL1 HGNC:15512 ENTREZ:81839 UNIPROT:Q8TAA9 GENECARDS:VANGL1 KEGG:81839 ATLASONC:GC_VANGL1 WIKI:VANGL1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="VANGL*"/> <bbox w="80.0" h="50.0" x="7325.25" y="2423.5"/> <glyph class="state variable" id="_000f9f27-8219-418d-95e8-ed54daebe78d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7400.25" y="2418.5"/> </glyph> <glyph class="state variable" id="_d379cda6-e2cb-4fe5-bcb7-57380a3873cf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7400.25" y="2443.5"/> </glyph> <glyph class="state variable" id="_972abab1-e0b1-4f98-9779-60def965a534"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7320.25" y="2418.5"/> </glyph> <glyph class="state variable" id="_ba22c401-d098-4e4a-ae6a-72825244cbca"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7320.25" y="2443.5"/> </glyph> <glyph class="unit of information" id="_4d097e76-bf4f-40a2-888e-1b6814301359"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7342.75" y="2418.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s453_wnc1_wnc1_sa334"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 HUGO:GNB2L1 HGNC:4399 ENTREZ:10399 UNIPROT:P63244 GENECARDS:GNB2L1 KEGG:10399 ATLASONC:GNB2L1ID43285ch5q35 WIKI:GNB2L1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RACK1*"/> <bbox w="80.0" h="40.0" x="7315.25" y="2477.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s583_wnc1_wnc1_sa410"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: par-6 partitioning defective 6 homolog alpha (C. elegans) "par-6 (partitioning defective 6, C.elegans) homolog alpha" HUGO:PARD6A HGNC:15943 ENTREZ:50855 UNIPROT:Q9NPB6 GENECARDS:PARD6A REACTOME:97684 KEGG:50855 ATLASONC:GC_PARD6A WIKI:PARD6A Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PAR6*"/> <bbox w="80.0" h="40.0" x="7313.5" y="2530.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s958_wnc1_wnc1_sa662"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: R-spondin 3 "R-spondin 3 homolog (Xenopus laevis)", "thrombospondin, type I, domain containing 2", THSD2 HUGO:RSPO3 HGNC:20866 ENTREZ:84870 UNIPROT:Q9BXY4 GENECARDS:RSPO3 KEGG:84870 ATLASONC:GC_RSPO3 WIKI:RSPO3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RSPO3"/> <bbox w="50.0" h="40.0" x="7617.5" y="2557.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s455_wnc1_wnc1_csa50" compartmentRef="wnc1_wnc1_c7_wnc1_wnc1_ca9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC2*:CK1_epsilon_*:CTHRC1:DVL*:FZD*:GSK3*:PAR6*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2* Identifiers_end References_begin: PCP MODULE s_wnc1_re77(MAP:survival): CK1 delta phosphorylates residues in cluster I: S84, S82, S79, T71 and in cluster II: S5, S8, S11, S14, S17, S20. Note: Experiments were performed in Xenopus PMID:21316585 s_wnc1_re140(MAP:survival): PMID:11779461 PMID:18256687 References_end</body> </html> </notes> <label text="Fzl/ROR/Wnt/CK1ε/Dvl/Axin/GSK3"/> <bbox w="381.0" h="196.0" x="7306.5" y="2133.5"/> <glyph class="macromolecule" id="wnc1_wnc1_s741_wnc1_wnc1_sa335"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Complex formation with Fzl-7 and Ror2 PMID:20457807 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="7507.0" y="2161.0"/> <glyph class="unit of information" id="_ef532526-ee9a-48ee-8849-8c737ddec4d8"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7524.5" y="2156.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s742_wnc1_wnc1_sa336"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>ClasII: Wnt4,-5a,-5b, and -11 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="7495.0" y="2138.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s743_wnc1_wnc1_sa337"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="7400.5" y="2212.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s459_wnc1_wnc1_sa338"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="7495.75" y="2210.5"/> <glyph class="state variable" id="_401d43ae-0a99-4b65-9190-0b2519684ac8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7570.75" y="2205.5"/> </glyph> <glyph class="state variable" id="_0e56eb2b-ce4a-4be1-85f0-3c95c1fe0811"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7490.75" y="2205.5"/> </glyph> <glyph class="state variable" id="_98a6c7f1-4c0a-4329-bc17-29363990afa5"> <state value="P" variable="S139"/> <bbox w="35.0" h="10.0" x="7557.632" y="2245.5"/> </glyph> <glyph class="state variable" id="_f8a52d08-ba4a-436a-b184-76b6772ba8aa"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7490.75" y="2205.5"/> </glyph> <glyph class="state variable" id="_05fa52e7-3818-4b65-97e7-b18bf88b7887"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7570.75" y="2205.5"/> </glyph> <glyph class="state variable" id="_2b1c82c0-bdbb-4143-be11-49f720131adc"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7567.8833" y="2205.5"/> </glyph> <glyph class="state variable" id="_7635d53a-9b62-4df7-980f-db7bd8c4bfa4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7570.75" y="2245.5"/> </glyph> <glyph class="state variable" id="_3b4efe3c-bde0-449b-8840-bbf9b51cea5e"> <state value="P" variable="S142"/> <bbox w="35.0" h="10.0" x="7478.25" y="2245.2224"/> </glyph> <glyph class="state variable" id="_960120eb-0e0b-4269-aa52-ae8b30926ef6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7490.75" y="2245.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s459_wnc1_wnc1_sa339"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="7495.75" y="2256.5"/> <glyph class="state variable" id="_508b9bac-f4af-486d-85cd-a4cebc7e1f1a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7570.75" y="2251.5"/> </glyph> <glyph class="state variable" id="_f282a318-8653-4e48-af97-e3ecb506bfca"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7490.75" y="2251.5"/> </glyph> <glyph class="state variable" id="_d79bee84-6312-44c4-b8a9-2b0be0ca49e1"> <state value="P" variable="S139"/> <bbox w="35.0" h="10.0" x="7557.632" y="2291.5"/> </glyph> <glyph class="state variable" id="_dfc18537-de8e-4c5a-98e3-2e47da0b3678"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7490.75" y="2251.5"/> </glyph> <glyph class="state variable" id="_bf72394b-735c-45ba-a0ff-dbabb2c21d54"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7570.75" y="2251.5"/> </glyph> <glyph class="state variable" id="_118d4b28-8ea6-4c9e-a490-95a36238c97f"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7567.8833" y="2251.5"/> </glyph> <glyph class="state variable" id="_6aeb1c54-af2c-4b83-8b9f-19e60637e01e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7570.75" y="2291.5"/> </glyph> <glyph class="state variable" id="_88ece643-4303-4687-b5d0-a54d5d8dad53"> <state value="P" variable="S142"/> <bbox w="35.0" h="10.0" x="7478.25" y="2291.2224"/> </glyph> <glyph class="state variable" id="_df5d7978-4ff6-420e-bec7-9f50ee93305d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7490.75" y="2291.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s745_wnc1_wnc1_sa341"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC2 HGNC:19989 ENTREZ:29882 UNIPROT:Q9UJX6 GENECARDS:ANAPC2 REACTOME:84976 KEGG:29882 ATLASONC:GC_ANAPC2 WIKI:ANAPC2 axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC2 HGNC:19989 ENTREZ:29882 UNIPROT:Q9UJX6 GENECARDS:ANAPC2 REACTOME:84976 KEGG:29882 ATLASONC:GC_ANAPC2 WIKI:ANAPC2 axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="APC2*"/> <bbox w="80.0" h="40.0" x="7594.5" y="2218.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s746_wnc1_wnc1_sa342"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="7594.5" y="2260.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s747_wnc1_wnc1_sa343"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: collagen triple helix repeat containing 1 HUGO:CTHRC1 HGNC:18831 ENTREZ:115908 UNIPROT:Q96CG8 GENECARDS:CTHRC1 ATLASONC:CTHRC1ID40193ch8q22 WIKI:CTHRC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTHRC1"/> <bbox w="50.0" h="20.0" x="7538.25" y="2139.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s748_wnc1_wnc1_sa344"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end</body> </html> </notes> <label text="SYN4*"/> <bbox w="80.0" h="50.0" x="7409.25" y="2154.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s749_wnc1_wnc1_sa345"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="7403.25" y="2260.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s750_wnc1_wnc1_sa346"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: VANGL planar cell polarity protein 2 "vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila)", "vang-like 2 (van gogh, Drosophila)" HUGO:VANGL2 HGNC:15511 ENTREZ:57216 UNIPROT:Q9ULK5 GENECARDS:VANGL2 KEGG:57216 ATLASONC:GC_VANGL2 WIKI:VANGL2 VANGL planar cell polarity protein 1 "vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila)", "vang-like 1 (van gogh, Drosophila)" HUGO:VANGL1 HGNC:15512 ENTREZ:81839 UNIPROT:Q8TAA9 GENECARDS:VANGL1 KEGG:81839 ATLASONC:GC_VANGL1 WIKI:VANGL1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="VANGL*"/> <bbox w="80.0" h="50.0" x="7324.25" y="2154.5"/> <glyph class="state variable" id="_140b58cd-d1a1-43a1-bb44-32269a7cb385"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7396.75" y="2149.5"/> </glyph> <glyph class="state variable" id="_a3b0dbef-588e-4e05-898b-475453e46267"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7396.75" y="2174.5"/> </glyph> <glyph class="state variable" id="_adcf28c9-4d6c-4ef9-9ad4-1bdbecca39f3"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7316.75" y="2149.5"/> </glyph> <glyph class="state variable" id="_b8d98827-17c0-480a-a069-3f2d8c4ff8b5"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7316.75" y="2174.5"/> </glyph> <glyph class="unit of information" id="_68200a4f-4561-4818-bf1e-d05f1ec0d1b3"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7341.75" y="2149.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s751_wnc1_wnc1_sa347"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 HUGO:GNB2L1 HGNC:4399 ENTREZ:10399 UNIPROT:P63244 GENECARDS:GNB2L1 KEGG:10399 ATLASONC:GNB2L1ID43285ch5q35 WIKI:GNB2L1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RACK1*"/> <bbox w="80.0" h="40.0" x="7314.25" y="2208.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s752_wnc1_wnc1_sa348"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ROR2"/> <bbox w="80.0" h="50.0" x="7591.0" y="2165.0"/> <glyph class="state variable" id="_a3c1d2f1-f9d1-436d-8886-9791c09fdd1b"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7623.5" y="2210.0"/> </glyph> <glyph class="state variable" id="_49d1c12d-2e7d-495f-bc15-2b24aea9ebe1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7586.0" y="2160.0"/> </glyph> <glyph class="state variable" id="_5277370b-2a0a-4ddb-b9fb-814eaf6fedf5"> <state value="P" variable="S864"/> <bbox w="35.0" h="10.0" x="7653.5" y="2160.2686"/> </glyph> <glyph class="state variable" id="_82a7a175-74f9-4284-93d3-21380f9a1f2d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7663.5" y="2210.0"/> </glyph> <glyph class="unit of information" id="_6d66f214-df14-4715-8cb3-ed385fe7ef42"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7608.5" y="2160.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s753_wnc1_wnc1_sa409"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: par-6 partitioning defective 6 homolog alpha (C. elegans) "par-6 (partitioning defective 6, C.elegans) homolog alpha" HUGO:PARD6A HGNC:15943 ENTREZ:50855 UNIPROT:Q9NPB6 GENECARDS:PARD6A REACTOME:97684 KEGG:50855 ATLASONC:GC_PARD6A WIKI:PARD6A Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PAR6*"/> <bbox w="80.0" h="40.0" x="7318.5" y="2258.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s959_wnc1_wnc1_sa663"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: R-spondin 3 "R-spondin 3 homolog (Xenopus laevis)", "thrombospondin, type I, domain containing 2", THSD2 HUGO:RSPO3 HGNC:20866 ENTREZ:84870 UNIPROT:Q9BXY4 GENECARDS:RSPO3 KEGG:84870 ATLASONC:GC_RSPO3 WIKI:RSPO3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RSPO3"/> <bbox w="50.0" h="40.0" x="7610.5" y="2289.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s489_wnc1_wnc1_csa51" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK1_epsilon_*:CTHRC1:FZD*:PAR6*:PRICKLE1:RACK1*:ROR2:SYN4*:VANGL*:WNT*:_beta_-Arrestin2* Identifiers_end References_begin: PCP MODULE This ends the signalling of the PCP-MODULE References_end</body> </html> </notes> <label text="CK1ε*:CTHRC1:FZD*:PAR6*:PRICKLE1:RACK1*:ROR2:SYN4*:VANGL*:WNT*:β-Arrestin2*"/> <bbox w="400.0" h="201.0" x="8674.5" y="1712.5"/> <glyph class="macromolecule" id="wnc1_wnc1_s490_wnc1_wnc1_sa354"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Complex formation with Fzl-7 and Ror2 PMID:20457807 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="8875.0" y="1740.0"/> <glyph class="unit of information" id="_8d149ea7-ff8c-402b-aa60-7bc434bede11"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8892.5" y="1735.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s491_wnc1_wnc1_sa355"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>ClasII: Wnt4,-5a,-5b, and -11 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="8863.0" y="1717.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s492_wnc1_wnc1_sa356"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="8768.5" y="1791.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s497_wnc1_wnc1_sa362"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: collagen triple helix repeat containing 1 HUGO:CTHRC1 HGNC:18831 ENTREZ:115908 UNIPROT:Q96CG8 GENECARDS:CTHRC1 ATLASONC:CTHRC1ID40193ch8q22 WIKI:CTHRC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTHRC1"/> <bbox w="50.0" h="20.0" x="8906.25" y="1718.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s498_wnc1_wnc1_sa363"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end</body> </html> </notes> <label text="SYN4*"/> <bbox w="80.0" h="50.0" x="8777.25" y="1733.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s499_wnc1_wnc1_sa364"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="8854.25" y="1842.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s501_wnc1_wnc1_sa366"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 HUGO:GNB2L1 HGNC:4399 ENTREZ:10399 UNIPROT:P63244 GENECARDS:GNB2L1 KEGG:10399 ATLASONC:GNB2L1ID43285ch5q35 WIKI:GNB2L1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RACK1*"/> <bbox w="80.0" h="40.0" x="8682.25" y="1787.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s821_wnc1_wnc1_sa538"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: prickle homolog 1 (Drosophila) "prickle-like 1 (Drosophila)" HUGO:PRICKLE1 HGNC:17019 ENTREZ:144165 UNIPROT:Q96MT3 GENECARDS:PRICKLE1 KEGG:144165 ATLASONC:GC_PRICKLE1 WIKI:PRICKLE1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Prickle is actually associated with membrane References_end</body> </html> </notes> <label text="PRICKLE1"/> <bbox w="80.0" h="40.0" x="8685.5" y="1840.0"/> <glyph class="state variable" id="_b66973d8-fa21-4b82-91d8-1aa7a2aefc94"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8758.0" y="1835.0"/> </glyph> <glyph class="state variable" id="_e5d6c956-5496-4f28-a421-2c5ae8dd7d20"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8680.5" y="1835.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s822_wnc1_wnc1_sa539"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: par-6 partitioning defective 6 homolog alpha (C. elegans) "par-6 (partitioning defective 6, C.elegans) homolog alpha" HUGO:PARD6A HGNC:15943 ENTREZ:50855 UNIPROT:Q9NPB6 GENECARDS:PARD6A REACTOME:97684 KEGG:50855 ATLASONC:GC_PARD6A WIKI:PARD6A Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PAR6*"/> <bbox w="80.0" h="40.0" x="8772.5" y="1837.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s830_wnc1_wnc1_sa544"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: VANGL planar cell polarity protein 2 "vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila)", "vang-like 2 (van gogh, Drosophila)" HUGO:VANGL2 HGNC:15511 ENTREZ:57216 UNIPROT:Q9ULK5 GENECARDS:VANGL2 KEGG:57216 ATLASONC:GC_VANGL2 WIKI:VANGL2 VANGL planar cell polarity protein 1 "vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila)", "vang-like 1 (van gogh, Drosophila)" HUGO:VANGL1 HGNC:15512 ENTREZ:81839 UNIPROT:Q8TAA9 GENECARDS:VANGL1 KEGG:81839 ATLASONC:GC_VANGL1 WIKI:VANGL1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="VANGL*"/> <bbox w="80.0" h="50.0" x="8687.5" y="1731.0"/> <glyph class="state variable" id="_dd430463-0328-4f95-b515-0c332e6a935d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8762.5" y="1726.0"/> </glyph> <glyph class="state variable" id="_e486abed-c440-45a4-b408-5030064ae5f9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8762.5" y="1751.0"/> </glyph> <glyph class="state variable" id="_a3106374-1b78-4716-8309-32f41ef4e281"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8682.5" y="1726.0"/> </glyph> <glyph class="state variable" id="_b6863afa-ff58-4d18-a63b-70573d8995f6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8682.5" y="1751.0"/> </glyph> <glyph class="unit of information" id="_5ed3aa40-00d8-437f-a8c2-eb6cdaed1e23"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8705.0" y="1726.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s831_wnc1_wnc1_sa545"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ROR2"/> <bbox w="80.0" h="50.0" x="8966.0" y="1740.0"/> <glyph class="state variable" id="_06ef6db2-336c-4998-99db-38fc9fdda183"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9001.0" y="1785.0"/> </glyph> <glyph class="state variable" id="_e59fc9c0-9135-4179-b837-74da6ec1c562"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8961.0" y="1735.0"/> </glyph> <glyph class="state variable" id="_5991c9c8-e510-4984-adc7-a9ac8407ff4f"> <state value="" variable="S864"/> <bbox w="30.0" h="10.0" x="9031.0" y="1735.2684"/> </glyph> <glyph class="state variable" id="_a4d94ded-41ed-47c2-a7e9-cae806e388c8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9041.0" y="1785.0"/> </glyph> <glyph class="unit of information" id="_d28e3a5d-876e-47d9-befe-3be68ac99f2f"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8983.5" y="1735.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s600_wnc1_wnc1_csa53" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK1_epsilon_*:CTHRC1:DVL*:FZD*:PAR6*:PRICKLE1:RACK1*:ROR2:SYN4*:VANGL*:WNT*:_beta_-Arrestin2* Identifiers_end References_begin: PCP MODULE s_wnc1_re86:(MAP:survival) PMID:17030191 References_end</body> </html> </notes> <label text="Fzl/ROR/Wnt/CK1ε/Dvl/Axin/GSK3"/> <bbox w="400.0" h="201.0" x="8660.5" y="2047.5"/> <glyph class="macromolecule" id="wnc1_wnc1_s601_wnc1_wnc1_sa383"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Complex formation with Fzl-7 and Ror2 PMID:20457807 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="8861.0" y="2075.0"/> <glyph class="unit of information" id="_0796d0c1-1cbb-46e9-b81f-5f1764c3719d"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8878.5" y="2070.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s602_wnc1_wnc1_sa384"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>ClasII: Wnt4,-5a,-5b, and -11 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="8849.0" y="2052.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s705_wnc1_wnc1_sa385"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="8754.5" y="2126.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s606_wnc1_wnc1_sa391"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: collagen triple helix repeat containing 1 HUGO:CTHRC1 HGNC:18831 ENTREZ:115908 UNIPROT:Q96CG8 GENECARDS:CTHRC1 ATLASONC:CTHRC1ID40193ch8q22 WIKI:CTHRC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTHRC1"/> <bbox w="50.0" h="20.0" x="8892.25" y="2053.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s607_wnc1_wnc1_sa392"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end</body> </html> </notes> <label text="SYN4*"/> <bbox w="80.0" h="50.0" x="8763.25" y="2068.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s608_wnc1_wnc1_sa393"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="8840.25" y="2177.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s609_wnc1_wnc1_sa394"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: VANGL planar cell polarity protein 2 "vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila)", "vang-like 2 (van gogh, Drosophila)" HUGO:VANGL2 HGNC:15511 ENTREZ:57216 UNIPROT:Q9ULK5 GENECARDS:VANGL2 KEGG:57216 ATLASONC:GC_VANGL2 WIKI:VANGL2 VANGL planar cell polarity protein 1 "vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila)", "vang-like 1 (van gogh, Drosophila)" HUGO:VANGL1 HGNC:15512 ENTREZ:81839 UNIPROT:Q8TAA9 GENECARDS:VANGL1 KEGG:81839 ATLASONC:GC_VANGL1 WIKI:VANGL1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="VANGL*"/> <bbox w="80.0" h="50.0" x="8678.25" y="2068.5"/> <glyph class="state variable" id="_d120ca7f-f099-4581-9aff-16bdaf10e6c1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8753.25" y="2063.5"/> </glyph> <glyph class="state variable" id="_6ff81715-00c4-408b-ab9c-5787425715c1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8753.25" y="2088.5"/> </glyph> <glyph class="state variable" id="_d1422e67-0b5b-4ed4-a0b9-d01b70dd93ec"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8673.25" y="2063.5"/> </glyph> <glyph class="state variable" id="_d9ccb7bf-3ac4-4f04-8c47-d9083308618b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8673.25" y="2088.5"/> </glyph> <glyph class="unit of information" id="_cc7acfbd-f056-47ef-84b8-f7cc0f4964e3"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8695.75" y="2063.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s710_wnc1_wnc1_sa395"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 HUGO:GNB2L1 HGNC:4399 ENTREZ:10399 UNIPROT:P63244 GENECARDS:GNB2L1 KEGG:10399 ATLASONC:GNB2L1ID43285ch5q35 WIKI:GNB2L1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RACK1*"/> <bbox w="80.0" h="40.0" x="8668.25" y="2122.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s611_wnc1_wnc1_sa396"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ROR2"/> <bbox w="80.0" h="50.0" x="8945.0" y="2079.0"/> <glyph class="state variable" id="_a9c195d7-ba64-4af1-9b31-386306202be6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8980.0" y="2124.0"/> </glyph> <glyph class="state variable" id="_e5ddcec7-d17d-4efc-bcd7-ca1981fed838"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8940.0" y="2074.0"/> </glyph> <glyph class="state variable" id="_797fed02-d2ae-4d5b-a9d0-2db2ad486f80"> <state value="" variable="S864"/> <bbox w="30.0" h="10.0" x="9010.0" y="2074.2686"/> </glyph> <glyph class="state variable" id="_a1de1a55-b76f-4a48-9920-04b3723b4a87"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9020.0" y="2124.0"/> </glyph> <glyph class="unit of information" id="_3eabb5b4-1d96-47fb-b124-679b1e706bbc"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8962.5" y="2074.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s612_wnc1_wnc1_sa397"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: prickle homolog 1 (Drosophila) "prickle-like 1 (Drosophila)" HUGO:PRICKLE1 HGNC:17019 ENTREZ:144165 UNIPROT:Q96MT3 GENECARDS:PRICKLE1 KEGG:144165 ATLASONC:GC_PRICKLE1 WIKI:PRICKLE1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Prickle is actually associated with membrane References_end</body> </html> </notes> <label text="PRICKLE1"/> <bbox w="80.0" h="40.0" x="8668.5" y="2176.0"/> <glyph class="state variable" id="_212eac0a-5081-466b-a630-b1154ca3b036"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8741.0" y="2171.0"/> </glyph> <glyph class="state variable" id="_b6430a2d-0a90-48d0-985c-a0070fece664"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8663.5" y="2171.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s711_wnc1_wnc1_sa411"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: par-6 partitioning defective 6 homolog alpha (C. elegans) "par-6 (partitioning defective 6, C.elegans) homolog alpha" HUGO:PARD6A HGNC:15943 ENTREZ:50855 UNIPROT:Q9NPB6 GENECARDS:PARD6A REACTOME:97684 KEGG:50855 ATLASONC:GC_PARD6A WIKI:PARD6A Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PAR6*"/> <bbox w="80.0" h="40.0" x="8753.5" y="2173.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s826_wnc1_wnc1_sa540"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="8938.25" y="2183.5"/> <glyph class="state variable" id="_3328e29c-8579-4dd8-9e61-61ccc9b693b2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9013.25" y="2178.5"/> </glyph> <glyph class="state variable" id="_9d379d77-a33f-4173-8c6a-d2b04c092f37"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8933.25" y="2178.5"/> </glyph> <glyph class="state variable" id="_85022d45-cf19-4d01-a7c6-26f2f94a2b6f"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="9002.632" y="2218.5"/> </glyph> <glyph class="state variable" id="_287bd351-135f-4eaa-bfdd-d6f7a3387337"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8933.25" y="2178.5"/> </glyph> <glyph class="state variable" id="_5039c6a6-f531-43a3-a42c-0e0c3c4dcc13"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9013.25" y="2178.5"/> </glyph> <glyph class="state variable" id="_c93c61a2-f23f-4d5f-aa9e-587af22d6c86"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9010.384" y="2178.5"/> </glyph> <glyph class="state variable" id="_29226579-0115-4d39-848c-4c08516633dc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9013.25" y="2218.5"/> </glyph> <glyph class="state variable" id="_b6e213b6-b2a7-40e7-bfd6-a28fae906de5"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="8923.25" y="2218.2224"/> </glyph> <glyph class="state variable" id="_bd2bb78e-47ad-4094-9d8f-9e9aea2adb47"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8933.25" y="2218.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s826_wnc1_wnc1_sa541"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="8941.25" y="2136.5"/> <glyph class="state variable" id="_c2cf12d7-083e-4c08-b247-ce14aadd113a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9016.25" y="2131.5"/> </glyph> <glyph class="state variable" id="_5b9bef00-5ed2-4f79-88b0-60cdfcbf68cf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8936.25" y="2131.5"/> </glyph> <glyph class="state variable" id="_67d2e017-f94f-4d02-8bdd-248f64a3ac86"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="9005.632" y="2171.5"/> </glyph> <glyph class="state variable" id="_8815611f-6be2-4db0-97c1-801d77d3c084"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8936.25" y="2131.5"/> </glyph> <glyph class="state variable" id="_1c33376b-1388-43ab-a659-7f7713254afe"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9016.25" y="2131.5"/> </glyph> <glyph class="state variable" id="_478322f4-8d8d-4273-9ef0-7613a5808684"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9013.384" y="2131.5"/> </glyph> <glyph class="state variable" id="_6ebe3f3f-4f07-4e0c-855a-5cba4c3a9f70"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9016.25" y="2171.5"/> </glyph> <glyph class="state variable" id="_bdbf58a3-5f00-4604-8916-e222531337db"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="8926.25" y="2171.2224"/> </glyph> <glyph class="state variable" id="_b9a4fc7f-e960-4773-9002-82bc27f182b4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8936.25" y="2171.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s686_wnc1_wnc1_csa55" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK1_epsilon_*:CTHRC1:DVL*:FZD*:PAR6*:PRICKLE1:PRR*:RACK1*:ROR2:SMURF1:SYN4*:VANGL*:WNT*:_beta_-Arrestin2* Identifiers_end References_begin: PCP MODULE s_wnc1_re88(MAP:survival): Smurf associates upon binding of Wnt5 to frizzled PMID:19379695 s_wnc1_re89(MAP:survival): Ubiquitination of Prickle by Smurf PMID:20930545 References_end</body> </html> </notes> <label text="Fzl/ROR/Wnt/CK1ε/Dvl"/> <bbox w="371.0" h="214.0" x="9287.5" y="2341.5"/> <glyph class="macromolecule" id="wnc1_wnc1_s687_wnc1_wnc1_sa429"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Complex formation with Fzl-7 and Ror2 PMID:20457807 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="9455.0" y="2370.0"/> <glyph class="unit of information" id="_13904ec1-5522-4469-af1d-3d57785d3ad3"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9472.5" y="2365.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s688_wnc1_wnc1_sa430"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ROR2"/> <bbox w="80.0" h="50.0" x="9536.0" y="2370.0"/> <glyph class="state variable" id="_c1836c0f-40f7-4ffc-803e-c426476d590c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9571.0" y="2415.0"/> </glyph> <glyph class="state variable" id="_ec7d7f16-1646-4388-9dd9-7689d2500da9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9531.0" y="2365.0"/> </glyph> <glyph class="state variable" id="_04f0d79a-f3bf-40a1-be0d-18111b86502d"> <state value="" variable="S864"/> <bbox w="30.0" h="10.0" x="9601.0" y="2365.2686"/> </glyph> <glyph class="state variable" id="_16d60fb3-e67b-4b0c-9383-7e3ecf03d376"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9611.0" y="2415.0"/> </glyph> <glyph class="unit of information" id="_bc4aa435-5b1d-47b9-9713-1a97553aa058"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9553.5" y="2365.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s689_wnc1_wnc1_sa431"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>ClasII: Wnt4,-5a,-5b, and -11 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="9517.0" y="2346.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s690_wnc1_wnc1_sa432"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="9391.5" y="2421.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s692_wnc1_wnc1_sa436"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: collagen triple helix repeat containing 1 HUGO:CTHRC1 HGNC:18831 ENTREZ:115908 UNIPROT:Q96CG8 GENECARDS:CTHRC1 ATLASONC:CTHRC1ID40193ch8q22 WIKI:CTHRC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTHRC1"/> <bbox w="50.0" h="20.0" x="9559.5" y="2345.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s693_wnc1_wnc1_sa437"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end</body> </html> </notes> <label text="SYN4*"/> <bbox w="80.0" h="50.0" x="9372.5" y="2363.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s698_wnc1_wnc1_sa438"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="9476.5" y="2471.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s694_wnc1_wnc1_sa439"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: VANGL planar cell polarity protein 2 "vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila)", "vang-like 2 (van gogh, Drosophila)" HUGO:VANGL2 HGNC:15511 ENTREZ:57216 UNIPROT:Q9ULK5 GENECARDS:VANGL2 KEGG:57216 ATLASONC:GC_VANGL2 WIKI:VANGL2 VANGL planar cell polarity protein 1 "vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila)", "vang-like 1 (van gogh, Drosophila)" HUGO:VANGL1 HGNC:15512 ENTREZ:81839 UNIPROT:Q8TAA9 GENECARDS:VANGL1 KEGG:81839 ATLASONC:GC_VANGL1 WIKI:VANGL1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="VANGL*"/> <bbox w="80.0" h="50.0" x="9291.5" y="2358.5"/> <glyph class="state variable" id="_b5d9fa34-af4f-4628-b19d-11a85082e650"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9366.5" y="2353.5"/> </glyph> <glyph class="state variable" id="_811d6be3-af5e-4721-8d16-350d1e41eb28"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9366.5" y="2378.5"/> </glyph> <glyph class="state variable" id="_a7fc5788-5527-42b6-b156-35a41493f7be"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9286.5" y="2353.5"/> </glyph> <glyph class="state variable" id="_6380d534-ecae-44ba-916f-fd1dea0888fc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9286.5" y="2378.5"/> </glyph> <glyph class="unit of information" id="_aa9f32c2-b0bd-4146-b870-e352b5333f10"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9309.0" y="2353.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s695_wnc1_wnc1_sa440"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 HUGO:GNB2L1 HGNC:4399 ENTREZ:10399 UNIPROT:P63244 GENECARDS:GNB2L1 KEGG:10399 ATLASONC:GNB2L1ID43285ch5q35 WIKI:GNB2L1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RACK1*"/> <bbox w="80.0" h="40.0" x="9298.5" y="2411.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s696_wnc1_wnc1_sa441"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: prickle homolog 1 (Drosophila) "prickle-like 1 (Drosophila)" HUGO:PRICKLE1 HGNC:17019 ENTREZ:144165 UNIPROT:Q96MT3 GENECARDS:PRICKLE1 KEGG:144165 ATLASONC:GC_PRICKLE1 WIKI:PRICKLE1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Prickle is actually associated with membrane References_end</body> </html> </notes> <label text="PRICKLE1"/> <bbox w="80.0" h="40.0" x="9300.5" y="2455.5"/> <glyph class="state variable" id="_1830e64c-bfb0-4180-b1b1-5088cc4141ff"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9373.0" y="2450.5"/> </glyph> <glyph class="state variable" id="_76bb30a1-26b7-41b5-aec3-0453836990fc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9295.5" y="2450.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s697_wnc1_wnc1_sa442"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: par-6 partitioning defective 6 homolog alpha (C. elegans) "par-6 (partitioning defective 6, C.elegans) homolog alpha" HUGO:PARD6A HGNC:15943 ENTREZ:50855 UNIPROT:Q9NPB6 GENECARDS:PARD6A REACTOME:97684 KEGG:50855 ATLASONC:GC_PARD6A WIKI:PARD6A Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PAR6*"/> <bbox w="80.0" h="40.0" x="9302.5" y="2495.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s700_wnc1_wnc1_sa458"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: SMAD specific E3 ubiquitin protein ligase 1 HUGO:SMURF1 HGNC:16807 ENTREZ:57154 UNIPROT:Q9HCE7 GENECARDS:SMURF1 REACTOME:414424 ATLASONC:GC_SMURF1 WIKI:SMURF1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="SMURF1"/> <bbox w="80.0" h="40.0" x="9386.5" y="2466.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s829_wnc1_wnc1_sa542"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="9563.25" y="2471.5"/> <glyph class="state variable" id="_3194e169-dbe4-4825-9663-3589b4047d8a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9638.25" y="2466.5"/> </glyph> <glyph class="state variable" id="_43d7d89d-6903-40ba-a0bd-4fa1b13e6fb6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9558.25" y="2466.5"/> </glyph> <glyph class="state variable" id="_8ac14a3c-9793-4362-a556-0d27fffb4df2"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="9627.632" y="2506.5"/> </glyph> <glyph class="state variable" id="_33585499-ec00-4674-b937-f542413a54df"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9558.25" y="2466.5"/> </glyph> <glyph class="state variable" id="_bad1d37b-879b-4945-b356-071436aadd0b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9638.25" y="2466.5"/> </glyph> <glyph class="state variable" id="_57cd4ddc-1936-4f41-b39a-fbd05c2772fa"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9635.384" y="2466.5"/> </glyph> <glyph class="state variable" id="_64a517cc-2770-48bc-a566-3fb165528c13"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9638.25" y="2506.5"/> </glyph> <glyph class="state variable" id="_a7f39aa4-eb43-4050-a816-b4052ff43d4c"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="9548.25" y="2506.2224"/> </glyph> <glyph class="state variable" id="_8506e229-2a99-4d49-bc82-5b7a405e646e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9558.25" y="2506.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s829_wnc1_wnc1_sa543"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="9566.25" y="2424.5"/> <glyph class="state variable" id="_f6f98464-c43a-423b-ac3b-90b4c761a62c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9641.25" y="2419.5"/> </glyph> <glyph class="state variable" id="_3998e839-8745-4ee9-afe3-a1fc8e85fa8c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9561.25" y="2419.5"/> </glyph> <glyph class="state variable" id="_fc331283-3ec6-4263-b14e-d4906f6b7e61"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="9630.632" y="2459.5"/> </glyph> <glyph class="state variable" id="_527acd82-9dda-4cee-b9e8-1e10206bacfa"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9561.25" y="2419.5"/> </glyph> <glyph class="state variable" id="_4080c9cb-a40c-4287-abc5-608286204cbd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9641.25" y="2419.5"/> </glyph> <glyph class="state variable" id="_3ad05215-c908-4305-9b0d-58a250ae8b92"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9638.384" y="2419.5"/> </glyph> <glyph class="state variable" id="_75e42e16-6325-45e0-9355-07dd191c8e4d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9641.25" y="2459.5"/> </glyph> <glyph class="state variable" id="_5e889711-8ca5-41f3-9a96-54b00dcb0af8"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="9551.25" y="2459.2224"/> </glyph> <glyph class="state variable" id="_a0e009ff-eb41-40c5-99fd-5ae16c60e4df"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9561.25" y="2459.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s913_wnc1_wnc1_sa615"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end</body> </html> </notes> <label text="PRR*"/> <bbox w="80.0" h="40.0" x="9474.5" y="2427.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s701_wnc1_wnc1_csa56" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK1_epsilon_*:CTHRC1:DVL*:FZD*:PAR6*:PRICKLE1:PRR*:RACK1*:ROR2:SMURF1:SYN4*:VANGL*:WNT*:_beta_-Arrestin2* Identifiers_end References_begin: PCP MODULE s_wnc1_re89(MAP:survival): Ubiquitination of Prickle by Smurf PMID:19379695 PMID:20930545 s_wnc1_re111(MAP:survival): Rspo is required for clathrin-mediated endocytosis PMID:21397842 It has been shown that Dvl polymers are not associated with vesicles, therefore endocytosis of the complex is likely to be after Dvl polymerisation. PMID:16263762 References_end</body> </html> </notes> <label text="Fzl/ROR/Wnt/CK1ε/Dvl"/> <bbox w="358.0" h="203.0" x="9047.5" y="2570.5"/> <glyph class="macromolecule" id="wnc1_wnc1_s850_wnc1_wnc1_sa443"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Complex formation with Fzl-7 and Ror2 PMID:20457807 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="9215.0" y="2599.0"/> <glyph class="unit of information" id="_4e564f78-9cf6-4e7d-9f30-29432c4fb7f8"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9232.5" y="2594.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s851_wnc1_wnc1_sa444"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ROR2"/> <bbox w="80.0" h="50.0" x="9296.0" y="2599.0"/> <glyph class="state variable" id="_04bb8a2b-6fb3-428d-a1e7-39045032e63d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9331.0" y="2644.0"/> </glyph> <glyph class="state variable" id="_a98417c6-010b-4c1e-81c3-a18ae69369f1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9291.0" y="2594.0"/> </glyph> <glyph class="state variable" id="_0a9cad96-e315-4dfc-ba6f-127378008e92"> <state value="" variable="S864"/> <bbox w="30.0" h="10.0" x="9361.0" y="2594.2686"/> </glyph> <glyph class="state variable" id="_17493c8a-3f44-4093-afb8-d80ca48a4bfd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9371.0" y="2644.0"/> </glyph> <glyph class="unit of information" id="_00a735bf-706f-4f11-94c9-b686b5009fc1"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9313.5" y="2594.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s852_wnc1_wnc1_sa445"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>ClasII: Wnt4,-5a,-5b, and -11 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="9277.0" y="2575.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s860_wnc1_wnc1_sa446"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="9147.5" y="2650.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s853_wnc1_wnc1_sa450"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: collagen triple helix repeat containing 1 HUGO:CTHRC1 HGNC:18831 ENTREZ:115908 UNIPROT:Q96CG8 GENECARDS:CTHRC1 ATLASONC:CTHRC1ID40193ch8q22 WIKI:CTHRC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTHRC1"/> <bbox w="50.0" h="20.0" x="9319.5" y="2574.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s854_wnc1_wnc1_sa451"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end</body> </html> </notes> <label text="SYN4*"/> <bbox w="80.0" h="50.0" x="9132.5" y="2592.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s861_wnc1_wnc1_sa452"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="9238.5" y="2702.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s855_wnc1_wnc1_sa453"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: VANGL planar cell polarity protein 2 "vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila)", "vang-like 2 (van gogh, Drosophila)" HUGO:VANGL2 HGNC:15511 ENTREZ:57216 UNIPROT:Q9ULK5 GENECARDS:VANGL2 KEGG:57216 ATLASONC:GC_VANGL2 WIKI:VANGL2 VANGL planar cell polarity protein 1 "vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila)", "vang-like 1 (van gogh, Drosophila)" HUGO:VANGL1 HGNC:15512 ENTREZ:81839 UNIPROT:Q8TAA9 GENECARDS:VANGL1 KEGG:81839 ATLASONC:GC_VANGL1 WIKI:VANGL1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="VANGL*"/> <bbox w="80.0" h="50.0" x="9051.5" y="2587.5"/> <glyph class="state variable" id="_1166c60e-8e9d-4d9e-a3cf-564f40e36bab"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9126.5" y="2582.5"/> </glyph> <glyph class="state variable" id="_c0f14272-fd08-44dd-876e-4f9faeea811f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9126.5" y="2607.5"/> </glyph> <glyph class="state variable" id="_7b6a6005-42b4-4ebe-96ac-280c4c5e8e3a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9046.5" y="2582.5"/> </glyph> <glyph class="state variable" id="_3a7bdffb-f3d3-47f2-9dba-0d40de236706"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9046.5" y="2607.5"/> </glyph> <glyph class="unit of information" id="_3b4ce434-019e-4ae3-9adf-d81cc4d00f4e"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9069.0" y="2582.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s856_wnc1_wnc1_sa454"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 HUGO:GNB2L1 HGNC:4399 ENTREZ:10399 UNIPROT:P63244 GENECARDS:GNB2L1 KEGG:10399 ATLASONC:GNB2L1ID43285ch5q35 WIKI:GNB2L1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RACK1*"/> <bbox w="80.0" h="40.0" x="9058.5" y="2640.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s857_wnc1_wnc1_sa455"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: prickle homolog 1 (Drosophila) "prickle-like 1 (Drosophila)" HUGO:PRICKLE1 HGNC:17019 ENTREZ:144165 UNIPROT:Q96MT3 GENECARDS:PRICKLE1 KEGG:144165 ATLASONC:GC_PRICKLE1 WIKI:PRICKLE1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Prickle is actually associated with membrane References_end</body> </html> </notes> <label text="PRICKLE1"/> <bbox w="80.0" h="40.0" x="9060.5" y="2684.5"/> <glyph class="state variable" id="_49c64eef-65c1-4ab8-875d-5b7f04787d90"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9133.0" y="2679.5"/> </glyph> <glyph class="state variable" id="_89017734-6a4d-4c81-a931-d79b3ce398ed"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="9050.5" y="2679.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s858_wnc1_wnc1_sa456"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: par-6 partitioning defective 6 homolog alpha (C. elegans) "par-6 (partitioning defective 6, C.elegans) homolog alpha" HUGO:PARD6A HGNC:15943 ENTREZ:50855 UNIPROT:Q9NPB6 GENECARDS:PARD6A REACTOME:97684 KEGG:50855 ATLASONC:GC_PARD6A WIKI:PARD6A Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PAR6*"/> <bbox w="80.0" h="40.0" x="9062.5" y="2724.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s859_wnc1_wnc1_sa457"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: SMAD specific E3 ubiquitin protein ligase 1 HUGO:SMURF1 HGNC:16807 ENTREZ:57154 UNIPROT:Q9HCE7 GENECARDS:SMURF1 REACTOME:414424 ATLASONC:GC_SMURF1 WIKI:SMURF1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="SMURF1"/> <bbox w="80.0" h="40.0" x="9150.5" y="2703.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s832_wnc1_wnc1_sa546"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="9318.25" y="2662.5"/> <glyph class="state variable" id="_2e7542a7-1c21-422f-8d4f-5a4e882a7d61"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9393.25" y="2657.5"/> </glyph> <glyph class="state variable" id="_7c11258f-ff5e-4767-8ed3-3060068da61d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9313.25" y="2657.5"/> </glyph> <glyph class="state variable" id="_d6ee18c1-88df-4060-b180-3107ac19d354"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="9382.632" y="2697.5"/> </glyph> <glyph class="state variable" id="_061cd1ff-dd09-4ddf-a2b0-e22bbb66295d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9313.25" y="2657.5"/> </glyph> <glyph class="state variable" id="_acbf1d9b-7945-4a4c-836a-92e81425407f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9393.25" y="2657.5"/> </glyph> <glyph class="state variable" id="_b035974d-1846-4682-96da-08f263a96086"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9390.384" y="2657.5"/> </glyph> <glyph class="state variable" id="_c9d6d063-c871-4406-b3a4-e0ff7f633bd8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9393.25" y="2697.5"/> </glyph> <glyph class="state variable" id="_e34ecdc3-b138-4c5a-8e1a-486e302776a1"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="9303.25" y="2697.2224"/> </glyph> <glyph class="state variable" id="_eed009c3-8498-4e60-866c-95a1a2fea5db"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9313.25" y="2697.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s832_wnc1_wnc1_sa547"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="9315.25" y="2709.5"/> <glyph class="state variable" id="_82aa3c3f-98ed-4241-a5a6-4613b83f59ae"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9390.25" y="2704.5"/> </glyph> <glyph class="state variable" id="_0d5087cd-6d7e-43df-907f-bd0b18ffc46e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9310.25" y="2704.5"/> </glyph> <glyph class="state variable" id="_383cba45-3b53-4cc2-a4d5-5533c1f1e56e"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="9379.632" y="2744.5"/> </glyph> <glyph class="state variable" id="_0d8c346d-4b10-44b6-88cf-67fe6ba663fe"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9310.25" y="2704.5"/> </glyph> <glyph class="state variable" id="_cfecc668-1da9-4dc7-b625-11e334db86f1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9390.25" y="2704.5"/> </glyph> <glyph class="state variable" id="_8ad2b6fc-778f-4e94-b5fa-48d2d7a6960a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9387.384" y="2704.5"/> </glyph> <glyph class="state variable" id="_327ee91d-3d6f-48dc-a178-0547ea546691"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9390.25" y="2744.5"/> </glyph> <glyph class="state variable" id="_17ad3322-4c6f-493b-802f-e299f014596f"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="9300.25" y="2744.2224"/> </glyph> <glyph class="state variable" id="_1d456f05-c615-4017-aa71-50a32e02b1d7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9310.25" y="2744.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s914_wnc1_wnc1_sa616"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end</body> </html> </notes> <label text="PRR*"/> <bbox w="80.0" h="40.0" x="9231.5" y="2656.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s722_wnc1_wnc1_csa57" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DACT1:VANGL* Identifiers_end References_begin: s_wnc1_re91(MAP:survival): PMID:19701191 Dac1 primarly functions in beta-catenin-independent MODULEs PMID:21718540 References_end</body> </html> </notes> <label text="DACT1:VANGL*"/> <bbox w="100.0" h="120.0" x="8766.0" y="959.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s723_wnc1_wnc1_sa463"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dapper antagonist of beta-catenin homolog 1 (Xenopus laevis) "dapper homolog 1 antagonist of beta-catenin (xenopus)" HUGO:DACT1 HGNC:17748 ENTREZ:51339 UNIPROT:Q9NYF0 GENECARDS:DACT1 KEGG:51339 ATLASONC:GC_DACT1 WIKI:DACT1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: dapper antagonist of beta-catenin homolog 1 (Xenopus laevis) "dapper homolog 1 antagonist of beta-catenin (xenopus)" HUGO:DACT1 HGNC:17748 ENTREZ:51339 UNIPROT:Q9NYF0 GENECARDS:DACT1 KEGG:51339 ATLASONC:GC_DACT1 WIKI:DACT1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="DACT1"/> <bbox w="80.0" h="40.0" x="8776.5" y="973.0"/> <glyph class="state variable" id="_de69561a-ec90-4ef1-928c-03a629a814b2"> <state value="" variable="S237"/> <bbox w="30.0" h="10.0" x="8761.992" y="968.0"/> </glyph> <glyph class="state variable" id="_437136a1-b770-43e7-94b5-ba2e5375404a"> <state value="" variable="S827"/> <bbox w="30.0" h="10.0" x="8840.882" y="1008.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s721_wnc1_wnc1_sa464"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: VANGL planar cell polarity protein 2 "vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila)", "vang-like 2 (van gogh, Drosophila)" HUGO:VANGL2 HGNC:15511 ENTREZ:57216 UNIPROT:Q9ULK5 GENECARDS:VANGL2 KEGG:57216 ATLASONC:GC_VANGL2 WIKI:VANGL2 VANGL planar cell polarity protein 1 "vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila)", "vang-like 1 (van gogh, Drosophila)" HUGO:VANGL1 HGNC:15512 ENTREZ:81839 UNIPROT:Q8TAA9 GENECARDS:VANGL1 KEGG:81839 ATLASONC:GC_VANGL1 WIKI:VANGL1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="VANGL*"/> <bbox w="80.0" h="50.0" x="8777.5" y="1016.0"/> <glyph class="state variable" id="_4ff733d7-78af-4ca4-b9b3-62c5b2de23ae"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8852.5" y="1011.0"/> </glyph> <glyph class="state variable" id="_6affb1a7-50ce-45ba-a531-d15c975950b9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8852.5" y="1036.0"/> </glyph> <glyph class="state variable" id="_f9725f13-32b1-4f98-825e-011045918ec8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8772.5" y="1011.0"/> </glyph> <glyph class="state variable" id="_cc8e7513-97c0-4c04-b885-234fe9c645c7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8772.5" y="1036.0"/> </glyph> <glyph class="unit of information" id="_8413d399-2310-4e4d-9d10-1bc21cc0568c"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8795.0" y="1011.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s726_wnc1_wnc1_csa58" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DACT1:YWHAB Identifiers_end References_begin: s_wnc1_re94:(MAP:survival) PMID:21262972 References_end</body> </html> </notes> <label text="DACT1:YWHAB"/> <bbox w="100.0" h="120.0" x="8673.0" y="1324.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s727_wnc1_wnc1_sa468"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dapper antagonist of beta-catenin homolog 1 (Xenopus laevis) "dapper homolog 1 antagonist of beta-catenin (xenopus)" HUGO:DACT1 HGNC:17748 ENTREZ:51339 UNIPROT:Q9NYF0 GENECARDS:DACT1 KEGG:51339 ATLASONC:GC_DACT1 WIKI:DACT1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: dapper antagonist of beta-catenin homolog 1 (Xenopus laevis) "dapper homolog 1 antagonist of beta-catenin (xenopus)" HUGO:DACT1 HGNC:17748 ENTREZ:51339 UNIPROT:Q9NYF0 GENECARDS:DACT1 KEGG:51339 ATLASONC:GC_DACT1 WIKI:DACT1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="DACT1"/> <bbox w="80.0" h="40.0" x="8684.5" y="1376.0"/> <glyph class="state variable" id="_29cf3e01-8e8b-4c31-becc-fc97a74f53dc"> <state value="P" variable="S237"/> <bbox w="35.0" h="10.0" x="8667.492" y="1371.0"/> </glyph> <glyph class="state variable" id="_2c1252ef-27a6-48f1-affd-66cf61162c13"> <state value="P" variable="S827"/> <bbox w="35.0" h="10.0" x="8746.382" y="1411.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s1117_wnc1_wnc1_sa736"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Modules_begin: MODULE:WNT_CYTOSOL_NON_CANONICAL Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide "tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide", YWHAA HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="YWHAB"/> <bbox w="80.0" h="40.0" x="8686.5" y="1333.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s729_wnc1_wnc1_csa59" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DACT1:DVL* Identifiers_end References_begin: s_wnc1_re95:(MAP:survival) PMID:16446366 References_end</body> </html> </notes> <label text="DACT1:DVL*"/> <bbox w="100.0" h="120.0" x="8761.0" y="1553.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s731_wnc1_wnc1_sa469"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="8772.75" y="1606.0"/> <glyph class="state variable" id="_58fdbc11-ee06-4bce-be98-f3568c9f0ea7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8847.75" y="1601.0"/> </glyph> <glyph class="state variable" id="_d5af21d6-c6f3-413c-8653-6525971b1fe1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8767.75" y="1601.0"/> </glyph> <glyph class="state variable" id="_22f51ad1-52b8-448d-8b17-6d26a84a9c32"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="8837.132" y="1641.0"/> </glyph> <glyph class="state variable" id="_525e55e3-a288-418d-b3cd-4dfadc4ef317"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8767.75" y="1601.0"/> </glyph> <glyph class="state variable" id="_864347bf-b8c7-4f8e-a628-68e45abb613a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8847.75" y="1601.0"/> </glyph> <glyph class="state variable" id="_110c81ba-e4a8-4f51-85e3-4c55a3c19c54"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8847.384" y="1601.0"/> </glyph> <glyph class="state variable" id="_23f30f63-28eb-48a5-9c0f-658ac2da2532"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8847.75" y="1641.0"/> </glyph> <glyph class="state variable" id="_035b36af-a004-4558-84f3-24b9103e955a"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="8757.75" y="1640.7223"/> </glyph> <glyph class="state variable" id="_3a28c845-653c-43c0-abb7-e7426f2bbc95"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8767.75" y="1641.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s730_wnc1_wnc1_sa470"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dapper antagonist of beta-catenin homolog 1 (Xenopus laevis) "dapper homolog 1 antagonist of beta-catenin (xenopus)" HUGO:DACT1 HGNC:17748 ENTREZ:51339 UNIPROT:Q9NYF0 GENECARDS:DACT1 KEGG:51339 ATLASONC:GC_DACT1 WIKI:DACT1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: dapper antagonist of beta-catenin homolog 1 (Xenopus laevis) "dapper homolog 1 antagonist of beta-catenin (xenopus)" HUGO:DACT1 HGNC:17748 ENTREZ:51339 UNIPROT:Q9NYF0 GENECARDS:DACT1 KEGG:51339 ATLASONC:GC_DACT1 WIKI:DACT1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="DACT1"/> <bbox w="80.0" h="40.0" x="8772.75" y="1564.0"/> <glyph class="state variable" id="_9f20595b-f7da-4aae-8fb0-10e397ba5ecf"> <state value="" variable="S237"/> <bbox w="30.0" h="10.0" x="8758.242" y="1559.0"/> </glyph> <glyph class="state variable" id="_8ae89657-1418-4e5c-ba2a-98e9885ebfa6"> <state value="" variable="S827"/> <bbox w="30.0" h="10.0" x="8837.132" y="1599.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s848_wnc1_wnc1_csa66" compartmentRef="wnc1_wnc1_c7_wnc1_wnc1_ca9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK1_epsilon_*:CTHRC1:DVL*:FZD*:PAR6*:PRR*:RAC1:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2* Identifiers_end References_begin: PCP MODULE s_wnc1_re108(MAP:survival): Rac1 found to be associated with polymerised Dvl. PMID:20215527 PMID:18953287 DEP domain in Dvl is enough to activate Rac PMID:12533515 s_wnc1_re119(MAP:survival): PRR binds to subunits ATP6V0C/D of the ATPase to lower the pH in the endosome. The reason for this is unknown but it is speculated that a lower pH is required for remodeling of the actin skeleton. However, v-ATPase is necessary for signaling PMID:21796133 PMID:21380625 PMID:20093472 References_end</body> </html> </notes> <label text="Fzl/ROR/Wnt/CK1ε/Dvl"/> <bbox w="358.0" h="203.0" x="8173.5" y="1612.5"/> <glyph class="macromolecule" id="wnc1_wnc1_s835_wnc1_wnc1_sa563"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Complex formation with Fzl-7 and Ror2 PMID:20457807 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="8341.0" y="1641.0"/> <glyph class="unit of information" id="_8e503a5b-1ce4-4841-94a7-df3ac92a5a3e"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8358.5" y="1636.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s836_wnc1_wnc1_sa564"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ROR2"/> <bbox w="80.0" h="50.0" x="8422.0" y="1641.0"/> <glyph class="state variable" id="_6ede7bd3-bc20-4716-b4a0-dd106e932f59"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8457.0" y="1686.0"/> </glyph> <glyph class="state variable" id="_fcdf4ec3-087e-42dc-b2f0-865d69fe791b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8417.0" y="1636.0"/> </glyph> <glyph class="state variable" id="_8770256f-6190-446e-96d2-7d1b55bf6f62"> <state value="" variable="S864"/> <bbox w="30.0" h="10.0" x="8487.0" y="1636.2684"/> </glyph> <glyph class="state variable" id="_f8cf6204-434b-44c9-b208-4c0119ac03bc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8497.0" y="1686.0"/> </glyph> <glyph class="unit of information" id="_d0d4eb90-2269-43c8-bad3-970c6bcf6499"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8439.5" y="1636.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s837_wnc1_wnc1_sa565"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>ClasII: Wnt4,-5a,-5b, and -11 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="8403.0" y="1617.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s838_wnc1_wnc1_sa566"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: collagen triple helix repeat containing 1 HUGO:CTHRC1 HGNC:18831 ENTREZ:115908 UNIPROT:Q96CG8 GENECARDS:CTHRC1 ATLASONC:CTHRC1ID40193ch8q22 WIKI:CTHRC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTHRC1"/> <bbox w="50.0" h="20.0" x="8445.5" y="1616.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s839_wnc1_wnc1_sa567"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end</body> </html> </notes> <label text="SYN4*"/> <bbox w="80.0" h="50.0" x="8258.5" y="1634.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s840_wnc1_wnc1_sa568"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: VANGL planar cell polarity protein 2 "vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila)", "vang-like 2 (van gogh, Drosophila)" HUGO:VANGL2 HGNC:15511 ENTREZ:57216 UNIPROT:Q9ULK5 GENECARDS:VANGL2 KEGG:57216 ATLASONC:GC_VANGL2 WIKI:VANGL2 VANGL planar cell polarity protein 1 "vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila)", "vang-like 1 (van gogh, Drosophila)" HUGO:VANGL1 HGNC:15512 ENTREZ:81839 UNIPROT:Q8TAA9 GENECARDS:VANGL1 KEGG:81839 ATLASONC:GC_VANGL1 WIKI:VANGL1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="VANGL*"/> <bbox w="80.0" h="50.0" x="8177.5" y="1629.5"/> <glyph class="state variable" id="_63f54b85-ddc9-4645-9770-2697dea5b130"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8252.5" y="1624.5"/> </glyph> <glyph class="state variable" id="_1734c29b-ca4e-41d3-a49b-0c0931c0f426"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8252.5" y="1649.5"/> </glyph> <glyph class="state variable" id="_4ad8c705-037b-42ce-9f81-d0527e303840"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8172.5" y="1624.5"/> </glyph> <glyph class="state variable" id="_ce8ab358-1d1f-47e0-a073-f8fe94aa2254"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8172.5" y="1649.5"/> </glyph> <glyph class="unit of information" id="_4c551c7f-e067-4450-8dc3-4036451f284f"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8195.0" y="1624.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s841_wnc1_wnc1_sa569"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 HUGO:GNB2L1 HGNC:4399 ENTREZ:10399 UNIPROT:P63244 GENECARDS:GNB2L1 KEGG:10399 ATLASONC:GNB2L1ID43285ch5q35 WIKI:GNB2L1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RACK1*"/> <bbox w="80.0" h="40.0" x="8184.5" y="1682.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s843_wnc1_wnc1_sa571"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: par-6 partitioning defective 6 homolog alpha (C. elegans) "par-6 (partitioning defective 6, C.elegans) homolog alpha" HUGO:PARD6A HGNC:15943 ENTREZ:50855 UNIPROT:Q9NPB6 GENECARDS:PARD6A REACTOME:97684 KEGG:50855 ATLASONC:GC_PARD6A WIKI:PARD6A Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PAR6*"/> <bbox w="80.0" h="40.0" x="8187.5" y="1725.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s845_wnc1_wnc1_sa573"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="8273.5" y="1692.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s846_wnc1_wnc1_sa574"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="8362.5" y="1738.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s849_wnc1_wnc1_sa575"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="8444.25" y="1696.5"/> <glyph class="state variable" id="_a73e9e46-5553-451a-85a3-0363fa64eeb3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8519.25" y="1691.5"/> </glyph> <glyph class="state variable" id="_860c78dd-2199-4292-bba9-2e8bfa2a4c6c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8439.25" y="1691.5"/> </glyph> <glyph class="state variable" id="_bfa4514b-aea0-4664-be48-8a25946680ca"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="8508.632" y="1731.5"/> </glyph> <glyph class="state variable" id="_43e59aa3-f834-4cdd-97d2-33f4bcef7e60"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8439.25" y="1691.5"/> </glyph> <glyph class="state variable" id="_626c7838-7b15-40fc-af81-b2d5ed4188cc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8519.25" y="1691.5"/> </glyph> <glyph class="state variable" id="_082fbe57-5374-4124-b397-9edf0003bcc0"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8516.384" y="1691.5"/> </glyph> <glyph class="state variable" id="_a0a8acda-f817-4cf3-ac58-cbd32aae269b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8519.25" y="1731.5"/> </glyph> <glyph class="state variable" id="_65a34302-6f3f-4b42-89bc-22a97cea2a4c"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="8429.25" y="1731.2223"/> </glyph> <glyph class="state variable" id="_184e9606-2708-4d4c-9bf8-676d51563050"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8439.25" y="1731.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s849_wnc1_wnc1_sa576"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="8446.25" y="1740.5"/> <glyph class="state variable" id="_b6aa9086-0fcf-4a67-b99f-ae8005910ab6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8521.25" y="1735.5"/> </glyph> <glyph class="state variable" id="_d717c96c-e508-4d2c-9dbd-1076ec707368"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8441.25" y="1735.5"/> </glyph> <glyph class="state variable" id="_fddccc50-d2e6-43cd-958e-07a8f2673573"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="8510.632" y="1775.5"/> </glyph> <glyph class="state variable" id="_b29d6368-b485-4f72-be37-e93b980a774a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8441.25" y="1735.5"/> </glyph> <glyph class="state variable" id="_97e01f0e-be52-4113-9169-7d1eead8de70"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8521.25" y="1735.5"/> </glyph> <glyph class="state variable" id="_cd0da8b4-aa94-431b-b1ac-a78ddb88877d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8518.384" y="1735.5"/> </glyph> <glyph class="state variable" id="_b7d53bcc-bc76-4248-a55b-2e091c406deb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8521.25" y="1775.5"/> </glyph> <glyph class="state variable" id="_e6f9e130-3e0c-4e2b-bbad-91b4f2b44645"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="8431.25" y="1775.2223"/> </glyph> <glyph class="state variable" id="_7a1c1956-5020-474d-aa53-087164815d4f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8441.25" y="1775.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s862_wnc1_wnc1_sa577"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <bbox w="80.0" h="40.0" x="8275.5" y="1740.0"/> <glyph class="state variable" id="_29d81d76-9841-4149-a9d2-97da80b2e43a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8270.5" y="1755.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s927_wnc1_wnc1_sa626"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end</body> </html> </notes> <label text="PRR*"/> <bbox w="80.0" h="40.0" x="8361.5" y="1695.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s928_wnc1_wnc1_sa627"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: R-spondin 3 "R-spondin 3 homolog (Xenopus laevis)", "thrombospondin, type I, domain containing 2", THSD2 HUGO:RSPO3 HGNC:20866 ENTREZ:84870 UNIPROT:Q9BXY4 GENECARDS:RSPO3 KEGG:84870 ATLASONC:GC_RSPO3 WIKI:RSPO3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RSPO3"/> <bbox w="50.0" h="40.0" x="8195.5" y="1769.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s879_wnc1_wnc1_csa67" compartmentRef="wnc1_wnc1_c7_wnc1_wnc1_ca9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK1_epsilon_*:CTHRC1:DVL*:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2* Identifiers_end References_begin: PCP MODULE s_wnc1_re114(MAP:survival): Clathrin-mediated endocytosis PMID:21397842 PMID:20947020 PMID:19910923 RhoA branch of the PCP -MODULE when Dvl is hyper-phosphorylated by CK_epsilon PMID:18953287 s_wnc1_re109(MAP:survival): Polymerised Dvl act as scaffold for recruiting axin. PMID:21078818 GSK3 phosphorylates ROR2 PMID:17986005 References_end</body> </html> </notes> <label text="Fzl/ROR/Wnt/CK1ε/Dvl/Axin/GSK3"/> <bbox w="363.0" h="216.0" x="8145.75" y="2390.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s880_wnc1_wnc1_sa580"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Complex formation with Fzl-7 and Ror2 PMID:20457807 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="8335.25" y="2414.5"/> <glyph class="unit of information" id="_cf3e709e-26eb-42fe-b315-3fe5ad176156"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8352.75" y="2409.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s881_wnc1_wnc1_sa581"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ROR2"/> <bbox w="80.0" h="50.0" x="8416.25" y="2420.5"/> <glyph class="state variable" id="_e8975aca-774e-4fec-9fef-bb32301c8883"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8451.25" y="2465.5"/> </glyph> <glyph class="state variable" id="_7248036b-8b27-4960-9129-36d987fe603c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8411.25" y="2415.5"/> </glyph> <glyph class="state variable" id="_4b6ebd7e-4425-4634-a45e-b35030a5262d"> <state value="" variable="S864"/> <bbox w="30.0" h="10.0" x="8481.25" y="2415.7686"/> </glyph> <glyph class="state variable" id="_13bb5453-b617-4391-b819-2b8910c94809"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8491.25" y="2465.5"/> </glyph> <glyph class="unit of information" id="_13efd92d-2b9a-4953-9508-f4ac6518d7c4"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8433.75" y="2415.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s882_wnc1_wnc1_sa582"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>ClasII: Wnt4,-5a,-5b, and -11 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="8331.25" y="2395.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s883_wnc1_wnc1_sa583"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="8236.75" y="2469.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s884_wnc1_wnc1_sa584"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: collagen triple helix repeat containing 1 HUGO:CTHRC1 HGNC:18831 ENTREZ:115908 UNIPROT:Q96CG8 GENECARDS:CTHRC1 ATLASONC:CTHRC1ID40193ch8q22 WIKI:CTHRC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTHRC1"/> <bbox w="50.0" h="20.0" x="8371.75" y="2400.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s885_wnc1_wnc1_sa585"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end</body> </html> </notes> <label text="SYN4*"/> <bbox w="80.0" h="50.0" x="8249.75" y="2414.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s886_wnc1_wnc1_sa586"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="8241.75" y="2518.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s887_wnc1_wnc1_sa587"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: VANGL planar cell polarity protein 2 "vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila)", "vang-like 2 (van gogh, Drosophila)" HUGO:VANGL2 HGNC:15511 ENTREZ:57216 UNIPROT:Q9ULK5 GENECARDS:VANGL2 KEGG:57216 ATLASONC:GC_VANGL2 WIKI:VANGL2 VANGL planar cell polarity protein 1 "vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila)", "vang-like 1 (van gogh, Drosophila)" HUGO:VANGL1 HGNC:15512 ENTREZ:81839 UNIPROT:Q8TAA9 GENECARDS:VANGL1 KEGG:81839 ATLASONC:GC_VANGL1 WIKI:VANGL1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="VANGL*"/> <bbox w="80.0" h="50.0" x="8166.75" y="2413.5"/> <glyph class="state variable" id="_7c119ca5-23af-4645-835d-3163f24401f1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8241.75" y="2408.5"/> </glyph> <glyph class="state variable" id="_62ae2df0-6109-4951-9c69-722cc8b7680b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8241.75" y="2433.5"/> </glyph> <glyph class="state variable" id="_fc76c834-d11a-45a6-9677-a04bb6582822"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8161.75" y="2408.5"/> </glyph> <glyph class="state variable" id="_b7587f6e-f3a0-4053-9256-a32357c9b12f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8161.75" y="2433.5"/> </glyph> <glyph class="unit of information" id="_7390ec73-88f1-4c64-b3ac-66f739a73b14"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8184.25" y="2408.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s888_wnc1_wnc1_sa588"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 HUGO:GNB2L1 HGNC:4399 ENTREZ:10399 UNIPROT:P63244 GENECARDS:GNB2L1 KEGG:10399 ATLASONC:GNB2L1ID43285ch5q35 WIKI:GNB2L1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RACK1*"/> <bbox w="80.0" h="40.0" x="8153.75" y="2467.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s889_wnc1_wnc1_sa589"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: par-6 partitioning defective 6 homolog alpha (C. elegans) "par-6 (partitioning defective 6, C.elegans) homolog alpha" HUGO:PARD6A HGNC:15943 ENTREZ:50855 UNIPROT:Q9NPB6 GENECARDS:PARD6A REACTOME:97684 KEGG:50855 ATLASONC:GC_PARD6A WIKI:PARD6A Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PAR6*"/> <bbox w="80.0" h="40.0" x="8154.75" y="2517.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s892_wnc1_wnc1_sa590"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="8335.5" y="2473.0"/> <glyph class="state variable" id="_bbb05d63-5958-48be-8b60-6fb44b82cc7a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8410.5" y="2468.0"/> </glyph> <glyph class="state variable" id="_958791c0-afdf-46a3-b1a4-fac486f3336f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8330.5" y="2468.0"/> </glyph> <glyph class="state variable" id="_6e2ec4d7-4783-4a28-b87f-3379666fd238"> <state value="P" variable="S139"/> <bbox w="35.0" h="10.0" x="8397.382" y="2508.0"/> </glyph> <glyph class="state variable" id="_7df7fc14-14bf-4ecf-a405-1721f7199c95"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8330.5" y="2468.0"/> </glyph> <glyph class="state variable" id="_f189f96d-2100-4ccb-8da6-b9a1acfceb7a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8410.5" y="2468.0"/> </glyph> <glyph class="state variable" id="_50417bbe-0d63-4d0c-a3bc-4f28bfca44e2"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8407.634" y="2468.0"/> </glyph> <glyph class="state variable" id="_36fb8235-1255-42b4-9bb4-c961e99f2e74"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8410.5" y="2508.0"/> </glyph> <glyph class="state variable" id="_b835c092-8d41-4ed5-a683-baa000a980f3"> <state value="P" variable="S142"/> <bbox w="35.0" h="10.0" x="8318.0" y="2507.7224"/> </glyph> <glyph class="state variable" id="_e26c092a-15a4-44f6-82b8-211f97bdba02"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8330.5" y="2508.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s892_wnc1_wnc1_sa591"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="8336.5" y="2526.0"/> <glyph class="state variable" id="_45853c94-dd48-4bea-a7b3-89b8c432510d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8411.5" y="2521.0"/> </glyph> <glyph class="state variable" id="_68c584f6-d9f0-4587-bee3-f9bc2fc0d2b5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8331.5" y="2521.0"/> </glyph> <glyph class="state variable" id="_abb38b05-233f-40df-a9b8-3a96f500f9e3"> <state value="P" variable="S139"/> <bbox w="35.0" h="10.0" x="8398.382" y="2561.0"/> </glyph> <glyph class="state variable" id="_98dcc263-4050-421e-8535-e75cb3b7dccf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8331.5" y="2521.0"/> </glyph> <glyph class="state variable" id="_36202f79-ec2b-424c-9f6a-bbcab50e5006"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8411.5" y="2521.0"/> </glyph> <glyph class="state variable" id="_9dd80168-7964-464f-9319-61e5514e91a3"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8408.634" y="2521.0"/> </glyph> <glyph class="state variable" id="_b5074495-0b4f-40f6-9901-3984fddffa5e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8411.5" y="2561.0"/> </glyph> <glyph class="state variable" id="_6f496c24-6db5-441c-b566-f0bc005fa19a"> <state value="P" variable="S142"/> <bbox w="35.0" h="10.0" x="8319.0" y="2560.7224"/> </glyph> <glyph class="state variable" id="_5416200a-2ba9-40e8-a28c-7d303598b955"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8331.5" y="2561.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s917_wnc1_wnc1_sa619"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end</body> </html> </notes> <label text="PRR*"/> <bbox w="80.0" h="40.0" x="8420.5" y="2474.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s956_wnc1_wnc1_sa660"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: R-spondin 3 "R-spondin 3 homolog (Xenopus laevis)", "thrombospondin, type I, domain containing 2", THSD2 HUGO:RSPO3 HGNC:20866 ENTREZ:84870 UNIPROT:Q9BXY4 GENECARDS:RSPO3 KEGG:84870 ATLASONC:GC_RSPO3 WIKI:RSPO3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RSPO3"/> <bbox w="50.0" h="40.0" x="8435.5" y="2524.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s896_wnc1_wnc1_csa68" compartmentRef="wnc1_wnc1_c7_wnc1_wnc1_ca9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK1_epsilon_*:CTHRC1:DVL*:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2* Identifiers_end References_begin: PCP MODULE s_wnc1_re112(MAP:survival): Clathrin-mediated endocytosis PMID:21397842 PMID:20947020 PMID:19910923 PCP MODULE splits in Rac1 branch when Dvl is not hyper-phosphorylated PMID:18953287 s_wnc1_re108(MAP:survival): Rac1 found to be associated with polymerised Dvl. PMID:20215527 DEP domain in Dvl is enough to activate Rac PMID:12533515 References_end</body> </html> </notes> <label text="Fzl/ROR/Wnt/CK1ε/Dvl/Axin/GSK3"/> <bbox w="363.0" h="202.0" x="8151.75" y="1915.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s869_wnc1_wnc1_sa594"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Complex formation with Fzl-7 and Ror2 PMID:20457807 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="8341.25" y="1939.5"/> <glyph class="unit of information" id="_7a7d980b-046b-4bed-9770-e2dfb6bf9ea8"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8358.75" y="1934.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s870_wnc1_wnc1_sa595"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ROR2"/> <bbox w="80.0" h="50.0" x="8422.25" y="1945.5"/> <glyph class="state variable" id="_c09b260c-c5cc-4ab1-a0fd-6c64084b3992"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8457.25" y="1990.5"/> </glyph> <glyph class="state variable" id="_837c2bdc-37ff-423e-af2c-1bedfcf12e9c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8417.25" y="1940.5"/> </glyph> <glyph class="state variable" id="_3af488a0-3131-4253-ae8d-a3285a24f1c1"> <state value="" variable="S864"/> <bbox w="30.0" h="10.0" x="8487.25" y="1940.7684"/> </glyph> <glyph class="state variable" id="_e3a805eb-51f0-4d2f-9c0c-ec23beb480fa"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8497.25" y="1990.5"/> </glyph> <glyph class="unit of information" id="_5330b27b-7a2b-4069-b857-cbb6594ae6c5"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8439.75" y="1940.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s871_wnc1_wnc1_sa596"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>ClasII: Wnt4,-5a,-5b, and -11 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="8337.25" y="1920.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s872_wnc1_wnc1_sa597"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="8242.75" y="1994.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s873_wnc1_wnc1_sa598"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: collagen triple helix repeat containing 1 HUGO:CTHRC1 HGNC:18831 ENTREZ:115908 UNIPROT:Q96CG8 GENECARDS:CTHRC1 ATLASONC:CTHRC1ID40193ch8q22 WIKI:CTHRC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTHRC1"/> <bbox w="50.0" h="20.0" x="8377.75" y="1925.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s874_wnc1_wnc1_sa599"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end</body> </html> </notes> <label text="SYN4*"/> <bbox w="80.0" h="50.0" x="8255.75" y="1939.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s876_wnc1_wnc1_sa600"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: VANGL planar cell polarity protein 2 "vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila)", "vang-like 2 (van gogh, Drosophila)" HUGO:VANGL2 HGNC:15511 ENTREZ:57216 UNIPROT:Q9ULK5 GENECARDS:VANGL2 KEGG:57216 ATLASONC:GC_VANGL2 WIKI:VANGL2 VANGL planar cell polarity protein 1 "vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila)", "vang-like 1 (van gogh, Drosophila)" HUGO:VANGL1 HGNC:15512 ENTREZ:81839 UNIPROT:Q8TAA9 GENECARDS:VANGL1 KEGG:81839 ATLASONC:GC_VANGL1 WIKI:VANGL1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="VANGL*"/> <bbox w="80.0" h="50.0" x="8172.75" y="1938.5"/> <glyph class="state variable" id="_d22dc8dd-355b-4a7c-bb02-a8d9c01854ae"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8247.75" y="1933.5"/> </glyph> <glyph class="state variable" id="_018664d2-5a11-4bb3-ade3-b496545d20b7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8247.75" y="1958.5"/> </glyph> <glyph class="state variable" id="_46f8c0a3-b3c6-40e3-b2aa-a89e0685c3b5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8167.75" y="1933.5"/> </glyph> <glyph class="state variable" id="_a6063aa4-5f6b-4109-8416-040932a0cfd5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8167.75" y="1958.5"/> </glyph> <glyph class="unit of information" id="_f1156d0c-8c16-46d9-82cf-4f05074b1a4c"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8190.25" y="1933.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s877_wnc1_wnc1_sa601"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 HUGO:GNB2L1 HGNC:4399 ENTREZ:10399 UNIPROT:P63244 GENECARDS:GNB2L1 KEGG:10399 ATLASONC:GNB2L1ID43285ch5q35 WIKI:GNB2L1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RACK1*"/> <bbox w="80.0" h="40.0" x="8159.75" y="1992.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s878_wnc1_wnc1_sa602"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: par-6 partitioning defective 6 homolog alpha (C. elegans) "par-6 (partitioning defective 6, C.elegans) homolog alpha" HUGO:PARD6A HGNC:15943 ENTREZ:50855 UNIPROT:Q9NPB6 GENECARDS:PARD6A REACTOME:97684 KEGG:50855 ATLASONC:GC_PARD6A WIKI:PARD6A Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PAR6*"/> <bbox w="80.0" h="40.0" x="8160.75" y="2042.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s875_wnc1_wnc1_sa603"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="8247.75" y="2039.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s897_wnc1_wnc1_sa604"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="8334.5" y="1994.0"/> <glyph class="state variable" id="_46a1f716-4236-4f44-b132-89d8026f1fd3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8409.5" y="1989.0"/> </glyph> <glyph class="state variable" id="_e60d45f6-15cc-4879-8b80-97e55d414a37"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8329.5" y="1989.0"/> </glyph> <glyph class="state variable" id="_d0bbc237-d5e0-47ec-aa90-c114e6666714"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="8398.882" y="2029.0"/> </glyph> <glyph class="state variable" id="_30a0ea73-6a6c-4082-922b-0ddccf935efb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8329.5" y="1989.0"/> </glyph> <glyph class="state variable" id="_3ae95df6-6874-4c43-97c1-5595c7673f2e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8409.5" y="1989.0"/> </glyph> <glyph class="state variable" id="_21dac224-12ca-43e0-a848-c2b782742748"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8406.634" y="1989.0"/> </glyph> <glyph class="state variable" id="_23eb7687-1464-4263-b10f-f3cb1f1624c3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8409.5" y="2029.0"/> </glyph> <glyph class="state variable" id="_3482d42f-5a17-4a9c-a2a9-f238844fa148"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="8319.5" y="2028.7223"/> </glyph> <glyph class="state variable" id="_d6d11aa3-781b-4fb2-ac5d-88100e3be141"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8329.5" y="2029.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s897_wnc1_wnc1_sa605"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="8334.5" y="2041.0"/> <glyph class="state variable" id="_4f1d6fa2-535d-479d-842f-d788512ba532"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8409.5" y="2036.0"/> </glyph> <glyph class="state variable" id="_1bc6e13c-a7b8-4ea1-af3f-fe024729ca95"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8329.5" y="2036.0"/> </glyph> <glyph class="state variable" id="_10ee384c-1fdc-436c-84a2-3d55bf5f84e5"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="8398.882" y="2076.0"/> </glyph> <glyph class="state variable" id="_6a315dc5-2c0c-420b-a468-755c489c3aa2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8329.5" y="2036.0"/> </glyph> <glyph class="state variable" id="_c3c8d6f3-8972-4474-afc3-cd44a20687fb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8409.5" y="2036.0"/> </glyph> <glyph class="state variable" id="_ffe46d2e-4ca3-45c4-94da-b621ddb463fe"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8406.634" y="2036.0"/> </glyph> <glyph class="state variable" id="_5196fdb2-cc84-4faf-805c-ca89e6224034"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8409.5" y="2076.0"/> </glyph> <glyph class="state variable" id="_104d894d-0208-4927-8073-82dad72f2713"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="8319.5" y="2075.7224"/> </glyph> <glyph class="state variable" id="_4d32303c-a62d-4c00-a13b-6041699922fe"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8329.5" y="2076.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s895_wnc1_wnc1_sa606"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: R-spondin 3 "R-spondin 3 homolog (Xenopus laevis)", "thrombospondin, type I, domain containing 2", THSD2 HUGO:RSPO3 HGNC:20866 ENTREZ:84870 UNIPROT:Q9BXY4 GENECARDS:RSPO3 KEGG:84870 ATLASONC:GC_RSPO3 WIKI:RSPO3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RSPO3"/> <bbox w="50.0" h="40.0" x="8422.75" y="2038.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s916_wnc1_wnc1_sa618"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end</body> </html> </notes> <label text="PRR*"/> <bbox w="80.0" h="40.0" x="8423.5" y="2001.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s930_wnc1_wnc1_csa73" compartmentRef="wnc1_wnc1_c7_wnc1_wnc1_ca9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK1_epsilon_*:CTHRC1:DVL*:FZD*:PAR6*:PRR*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WNT*:_beta_-Arrestin2* Identifiers_end References_begin: PCP MODULE References_end</body> </html> </notes> <label text="Fzl/ROR/Wnt/CK1ε/Dvl"/> <bbox w="358.0" h="203.0" x="7771.5" y="1616.5"/> <glyph class="macromolecule" id="wnc1_wnc1_s931_wnc1_wnc1_sa630"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Complex formation with Fzl-7 and Ror2 PMID:20457807 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="7939.0" y="1645.0"/> <glyph class="unit of information" id="_605e5dbc-c73f-4dcc-bc8c-555e5cf826ec"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7956.5" y="1640.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s932_wnc1_wnc1_sa631"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ROR2"/> <bbox w="80.0" h="50.0" x="8020.0" y="1645.0"/> <glyph class="state variable" id="_033cf7e0-7e6f-4520-b6ac-91a36cd9ba9d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8055.0" y="1690.0"/> </glyph> <glyph class="state variable" id="_86c5f4c6-f8ad-402b-8490-15a4ffcfac33"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8015.0" y="1640.0"/> </glyph> <glyph class="state variable" id="_8e198e98-3e6f-401f-8674-fcde988f094f"> <state value="" variable="S864"/> <bbox w="30.0" h="10.0" x="8085.0" y="1640.2684"/> </glyph> <glyph class="state variable" id="_1870acbc-8930-4458-899f-d91e53fbd35a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8095.0" y="1690.0"/> </glyph> <glyph class="unit of information" id="_9680addf-4174-4e6a-a2d3-ce870a0136d9"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8037.5" y="1640.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s933_wnc1_wnc1_sa632"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>ClasII: Wnt4,-5a,-5b, and -11 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="8001.0" y="1621.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s934_wnc1_wnc1_sa633"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: collagen triple helix repeat containing 1 HUGO:CTHRC1 HGNC:18831 ENTREZ:115908 UNIPROT:Q96CG8 GENECARDS:CTHRC1 ATLASONC:CTHRC1ID40193ch8q22 WIKI:CTHRC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTHRC1"/> <bbox w="50.0" h="20.0" x="8043.5" y="1620.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s935_wnc1_wnc1_sa634"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end</body> </html> </notes> <label text="SYN4*"/> <bbox w="80.0" h="50.0" x="7856.5" y="1638.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s936_wnc1_wnc1_sa635"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: VANGL planar cell polarity protein 2 "vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila)", "vang-like 2 (van gogh, Drosophila)" HUGO:VANGL2 HGNC:15511 ENTREZ:57216 UNIPROT:Q9ULK5 GENECARDS:VANGL2 KEGG:57216 ATLASONC:GC_VANGL2 WIKI:VANGL2 VANGL planar cell polarity protein 1 "vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila)", "vang-like 1 (van gogh, Drosophila)" HUGO:VANGL1 HGNC:15512 ENTREZ:81839 UNIPROT:Q8TAA9 GENECARDS:VANGL1 KEGG:81839 ATLASONC:GC_VANGL1 WIKI:VANGL1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="VANGL*"/> <bbox w="80.0" h="50.0" x="7775.5" y="1633.5"/> <glyph class="state variable" id="_9e3402bc-3a6a-43a5-a0ae-c37eed6dc5cf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7850.5" y="1628.5"/> </glyph> <glyph class="state variable" id="_f3527b6f-9550-437d-947a-c455a412fd3f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7850.5" y="1653.5"/> </glyph> <glyph class="state variable" id="_4a543bad-7fd5-439e-bb58-a502c6e54cc2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7770.5" y="1628.5"/> </glyph> <glyph class="state variable" id="_e0bfc8d5-af54-424e-9273-3158faf68ee4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7770.5" y="1653.5"/> </glyph> <glyph class="unit of information" id="_4ee8c5c8-51b4-4b1f-a417-7aa379f14077"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7793.0" y="1628.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s937_wnc1_wnc1_sa636"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 HUGO:GNB2L1 HGNC:4399 ENTREZ:10399 UNIPROT:P63244 GENECARDS:GNB2L1 KEGG:10399 ATLASONC:GNB2L1ID43285ch5q35 WIKI:GNB2L1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RACK1*"/> <bbox w="80.0" h="40.0" x="7782.5" y="1686.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s938_wnc1_wnc1_sa637"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="7871.5" y="1696.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s939_wnc1_wnc1_sa639"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end</body> </html> </notes> <label text="PRR*"/> <bbox w="80.0" h="40.0" x="7959.5" y="1699.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s940_wnc1_wnc1_sa640"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="7960.5" y="1742.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s941_wnc1_wnc1_sa641"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="8042.25" y="1700.5"/> <glyph class="state variable" id="_efe96b66-bbba-48c0-a0ab-4e059a78ae3f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8117.25" y="1695.5"/> </glyph> <glyph class="state variable" id="_24b57827-399f-49e4-96dd-87ad3dff0f4a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8037.25" y="1695.5"/> </glyph> <glyph class="state variable" id="_36814e9d-d583-4180-9b0b-6062638d4ccf"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="8106.632" y="1735.5"/> </glyph> <glyph class="state variable" id="_2aef1dad-3299-4216-906a-e082ff5d6f66"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8037.25" y="1695.5"/> </glyph> <glyph class="state variable" id="_4937f419-0706-41e4-a002-3806c4cbb827"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8117.25" y="1695.5"/> </glyph> <glyph class="state variable" id="_e17e95c1-cc3b-44b7-9e08-5dc5b152f6d1"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8114.3833" y="1695.5"/> </glyph> <glyph class="state variable" id="_f141c968-69a2-44d5-b01c-e1c9a0fe68e2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8117.25" y="1735.5"/> </glyph> <glyph class="state variable" id="_9f52a633-4ac5-4f72-9c18-f422ce0bad15"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="8027.25" y="1735.2223"/> </glyph> <glyph class="state variable" id="_8605033a-066a-4505-99ce-d151429770ab"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8037.25" y="1735.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s941_wnc1_wnc1_sa642"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="8044.25" y="1744.5"/> <glyph class="state variable" id="_0b7694f8-284b-4a25-b1e7-d636e3fd6a84"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8119.25" y="1739.5"/> </glyph> <glyph class="state variable" id="_bdc90723-2ed9-419f-a79b-2e7b7ea299ce"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8039.25" y="1739.5"/> </glyph> <glyph class="state variable" id="_da7b5d4a-cfef-4f16-9a23-f7981650b91f"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="8108.632" y="1779.5"/> </glyph> <glyph class="state variable" id="_660c8b70-eec1-47fa-8fe8-2d2f965a7c7f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8039.25" y="1739.5"/> </glyph> <glyph class="state variable" id="_53c13a6f-4d9b-4820-a71d-0b6680d84b59"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8119.25" y="1739.5"/> </glyph> <glyph class="state variable" id="_4535f464-1272-4b1b-bc84-2cd72da43188"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8116.3833" y="1739.5"/> </glyph> <glyph class="state variable" id="_81bc6bfb-4eb1-47f4-9ab5-198b969f4090"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8119.25" y="1779.5"/> </glyph> <glyph class="state variable" id="_22cae197-1267-4c1d-b1c6-b9850144b98d"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="8029.25" y="1779.2223"/> </glyph> <glyph class="state variable" id="_0a043068-1c79-4614-a3c3-2089574bf4df"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8039.25" y="1779.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s942_wnc1_wnc1_sa643"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: par-6 partitioning defective 6 homolog alpha (C. elegans) "par-6 (partitioning defective 6, C.elegans) homolog alpha" HUGO:PARD6A HGNC:15943 ENTREZ:50855 UNIPROT:Q9NPB6 GENECARDS:PARD6A REACTOME:97684 KEGG:50855 ATLASONC:GC_PARD6A WIKI:PARD6A Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PAR6*"/> <bbox w="80.0" h="40.0" x="7785.5" y="1729.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s943_wnc1_wnc1_sa644"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: R-spondin 3 "R-spondin 3 homolog (Xenopus laevis)", "thrombospondin, type I, domain containing 2", THSD2 HUGO:RSPO3 HGNC:20866 ENTREZ:84870 UNIPROT:Q9BXY4 GENECARDS:RSPO3 KEGG:84870 ATLASONC:GC_RSPO3 WIKI:RSPO3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RSPO3"/> <bbox w="50.0" h="40.0" x="7793.5" y="1773.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s945_wnc1_wnc1_csa74" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:POSH*:RAC1 Identifiers_end References_begin: s_wnc1_re122:(MAP:survival) PMID:12514131 s_wnc1_re155:(MAP:survival) PMID:21619876 References_end</body> </html> </notes> <label text="POSH*:RAC1"/> <bbox w="100.0" h="120.0" x="7994.0" y="1345.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s946_wnc1_wnc1_sa646"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <bbox w="80.0" h="40.0" x="8005.25" y="1397.5"/> <glyph class="state variable" id="_f448a86e-f632-492e-ba48-0e1fd3ec073c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8000.25" y="1412.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s947_wnc1_wnc1_sa647"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: SH3 domain containing ring finger 1 "SH3 multiple domains 2", SH3MD2 HUGO:SH3RF1 HGNC:17650 ENTREZ:57630 UNIPROT:Q7Z6J0 GENECARDS:SH3RF1 KEGG:57630 ATLASONC:GC_SH3RF1 WIKI:SH3RF1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="POSH*"/> <bbox w="80.0" h="40.0" x="8005.25" y="1353.5"/> <glyph class="state variable" id="_a0838fe5-18fc-48d5-978e-57359c580048"> <state value="" variable="S304"/> <bbox w="30.0" h="10.0" x="8070.25" y="1348.7147"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s960_wnc1_wnc1_csa76" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC2*:CK1_epsilon_*:CTHRC1:DAAM1:DVL*:FZD*:GSK3*:PAR6*:RACK1*:RHOA:ROR2:RSPO3:SYN4*:VANGL*:WGEF*:WNT*:_beta_-Arrestin2* Identifiers_end References_begin: PCP MODULE s_wnc1_re140(MAP:survival): PMID:11779461 PMID:18256687 s_wnc1_re146:(MAP:survival) Not sure if Rho dissociates when active References_end</body> </html> </notes> <label text="Fzl/ROR/Wnt/CK1ε/Dvl/Axin/GSK3"/> <bbox w="381.0" h="244.0" x="7311.75" y="1761.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s987_wnc1_wnc1_sa664"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Complex formation with Fzl-7 and Ror2 PMID:20457807 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="7512.25" y="1788.5"/> <glyph class="unit of information" id="_e49c18ae-0bb5-4273-88b0-07dfb7486ec9"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7529.75" y="1783.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s988_wnc1_wnc1_sa665"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>ClasII: Wnt4,-5a,-5b, and -11 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="7500.25" y="1766.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s989_wnc1_wnc1_sa666"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="7405.75" y="1840.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s964_wnc1_wnc1_sa667"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="7501.0" y="1838.0"/> <glyph class="state variable" id="_6ea91019-1828-4a37-8702-e1f8a6c6ad8b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7576.0" y="1833.0"/> </glyph> <glyph class="state variable" id="_0f43e125-7d9d-433f-9264-d2c76552ba1f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7496.0" y="1833.0"/> </glyph> <glyph class="state variable" id="_f71a8b7e-4161-415c-a792-06fea4a8ebe7"> <state value="P" variable="S139"/> <bbox w="35.0" h="10.0" x="7562.882" y="1873.0"/> </glyph> <glyph class="state variable" id="_b5faf693-643d-4575-aaa8-31b7cc997f40"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7496.0" y="1833.0"/> </glyph> <glyph class="state variable" id="_2891931a-17b0-4d50-9171-cb57f6017c3b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7576.0" y="1833.0"/> </glyph> <glyph class="state variable" id="_3db17336-e3eb-4ca0-a749-6508630ed586"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7573.1333" y="1833.0"/> </glyph> <glyph class="state variable" id="_8f658b6a-93d2-4652-acb8-83058d7b6b50"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7576.0" y="1873.0"/> </glyph> <glyph class="state variable" id="_f7e9d904-6813-465d-b222-23f934e15c44"> <state value="P" variable="S142"/> <bbox w="35.0" h="10.0" x="7483.5" y="1872.7223"/> </glyph> <glyph class="state variable" id="_ce5faf5c-bf14-4b0c-9326-092a1483ec8a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7496.0" y="1873.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s964_wnc1_wnc1_sa668"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="7501.0" y="1884.0"/> <glyph class="state variable" id="_142eca74-85f6-46a0-acc9-eb974bf409cd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7576.0" y="1879.0"/> </glyph> <glyph class="state variable" id="_70119aaa-2aed-4a08-8300-e9fa1ce30cb1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7496.0" y="1879.0"/> </glyph> <glyph class="state variable" id="_3ce78ddb-2c6e-4037-9aba-7eb0c382ecda"> <state value="P" variable="S139"/> <bbox w="35.0" h="10.0" x="7562.882" y="1919.0"/> </glyph> <glyph class="state variable" id="_dc081714-a2a9-4288-8d47-66a158c307a3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7496.0" y="1879.0"/> </glyph> <glyph class="state variable" id="_e7ce2607-f98e-441a-8173-838a9e84bc5d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7576.0" y="1879.0"/> </glyph> <glyph class="state variable" id="_cbd19cfd-c09e-44d5-b013-94b0c820bb3e"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7573.1333" y="1879.0"/> </glyph> <glyph class="state variable" id="_13c56616-1da0-42e7-a001-d00077816647"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7576.0" y="1919.0"/> </glyph> <glyph class="state variable" id="_f6a0218f-7ab8-4494-88c6-cad4380d53f8"> <state value="P" variable="S142"/> <bbox w="35.0" h="10.0" x="7483.5" y="1918.7223"/> </glyph> <glyph class="state variable" id="_839bce0b-9dbe-4567-bae7-d292c0050a3b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7496.0" y="1919.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s990_wnc1_wnc1_sa669"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC2 HGNC:19989 ENTREZ:29882 UNIPROT:Q9UJX6 GENECARDS:ANAPC2 REACTOME:84976 KEGG:29882 ATLASONC:GC_ANAPC2 WIKI:ANAPC2 axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC2 HGNC:19989 ENTREZ:29882 UNIPROT:Q9UJX6 GENECARDS:ANAPC2 REACTOME:84976 KEGG:29882 ATLASONC:GC_ANAPC2 WIKI:ANAPC2 axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="APC2*"/> <bbox w="80.0" h="40.0" x="7599.75" y="1845.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s991_wnc1_wnc1_sa670"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="7599.75" y="1887.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s992_wnc1_wnc1_sa671"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: collagen triple helix repeat containing 1 HUGO:CTHRC1 HGNC:18831 ENTREZ:115908 UNIPROT:Q96CG8 GENECARDS:CTHRC1 ATLASONC:CTHRC1ID40193ch8q22 WIKI:CTHRC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTHRC1"/> <bbox w="50.0" h="20.0" x="7543.5" y="1767.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s993_wnc1_wnc1_sa672"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end</body> </html> </notes> <label text="SYN4*"/> <bbox w="80.0" h="50.0" x="7414.5" y="1782.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s994_wnc1_wnc1_sa673"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="7408.5" y="1888.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s995_wnc1_wnc1_sa674"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: VANGL planar cell polarity protein 2 "vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila)", "vang-like 2 (van gogh, Drosophila)" HUGO:VANGL2 HGNC:15511 ENTREZ:57216 UNIPROT:Q9ULK5 GENECARDS:VANGL2 KEGG:57216 ATLASONC:GC_VANGL2 WIKI:VANGL2 VANGL planar cell polarity protein 1 "vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila)", "vang-like 1 (van gogh, Drosophila)" HUGO:VANGL1 HGNC:15512 ENTREZ:81839 UNIPROT:Q8TAA9 GENECARDS:VANGL1 KEGG:81839 ATLASONC:GC_VANGL1 WIKI:VANGL1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="VANGL*"/> <bbox w="80.0" h="50.0" x="7329.5" y="1782.0"/> <glyph class="state variable" id="_1477aad2-5135-4f33-80d0-954d00214ee4"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7402.0" y="1777.0"/> </glyph> <glyph class="state variable" id="_7d506186-d34c-4a95-8572-07cf8f4167ab"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7402.0" y="1802.0"/> </glyph> <glyph class="state variable" id="_244ddd84-bc9b-4151-ac30-8f867cfb36ce"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7322.0" y="1777.0"/> </glyph> <glyph class="state variable" id="_15726e33-7383-44d9-bcbd-eafb5b1102f6"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7322.0" y="1802.0"/> </glyph> <glyph class="unit of information" id="_08a19bd1-8420-442f-a7d3-eb9e2c6e5f1d"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7347.0" y="1777.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s996_wnc1_wnc1_sa675"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 HUGO:GNB2L1 HGNC:4399 ENTREZ:10399 UNIPROT:P63244 GENECARDS:GNB2L1 KEGG:10399 ATLASONC:GNB2L1ID43285ch5q35 WIKI:GNB2L1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RACK1*"/> <bbox w="80.0" h="40.0" x="7319.5" y="1836.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s997_wnc1_wnc1_sa676"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ROR2"/> <bbox w="80.0" h="50.0" x="7596.25" y="1792.5"/> <glyph class="state variable" id="_bd657f71-1bc0-46d1-b5eb-d4cae6293959"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7628.75" y="1837.5"/> </glyph> <glyph class="state variable" id="_64ac48ec-bf88-47e9-b320-c64fc06b77b9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7591.25" y="1787.5"/> </glyph> <glyph class="state variable" id="_b7c63b64-9611-4ce4-b21d-0acd2d886085"> <state value="P" variable="S864"/> <bbox w="35.0" h="10.0" x="7658.75" y="1787.7684"/> </glyph> <glyph class="state variable" id="_d92451aa-cc48-4ae8-b0f3-4ef6d8975769"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7668.75" y="1837.5"/> </glyph> <glyph class="unit of information" id="_e21b5c8f-4909-44b7-8496-e3b431368ccb"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7613.75" y="1787.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s998_wnc1_wnc1_sa677"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: par-6 partitioning defective 6 homolog alpha (C. elegans) "par-6 (partitioning defective 6, C.elegans) homolog alpha" HUGO:PARD6A HGNC:15943 ENTREZ:50855 UNIPROT:Q9NPB6 GENECARDS:PARD6A REACTOME:97684 KEGG:50855 ATLASONC:GC_PARD6A WIKI:PARD6A Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PAR6*"/> <bbox w="80.0" h="40.0" x="7323.75" y="1885.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s999_wnc1_wnc1_sa678"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: R-spondin 3 "R-spondin 3 homolog (Xenopus laevis)", "thrombospondin, type I, domain containing 2", THSD2 HUGO:RSPO3 HGNC:20866 ENTREZ:84870 UNIPROT:Q9BXY4 GENECARDS:RSPO3 KEGG:84870 ATLASONC:GC_RSPO3 WIKI:RSPO3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RSPO3"/> <bbox w="50.0" h="40.0" x="7612.75" y="1929.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s1001_wnc1_wnc1_sa681"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: dishevelled associated activator of morphogenesis 1 HUGO:DAAM1 HGNC:18142 ENTREZ:23002 UNIPROT:Q9Y4D1 GENECARDS:DAAM1 ATLASONC:GC_DAAM1 WIKI:DAAM1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="DAAM1"/> <bbox w="80.0" h="40.0" x="7502.5" y="1933.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s1000_wnc1_wnc1_sa682"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Rho guanine nucleotide exchange factor (GEF) 19 HUGO:ARHGEF19 HGNC:26604 ENTREZ:128272 UNIPROT:Q8IW93 GENECARDS:ARHGEF19 KEGG:128272 ATLASONC:GC_ARHGEF19 WIKI:ARHGEF19 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="WGEF*"/> <bbox w="80.0" h="40.0" x="7416.5" y="1932.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s1002_wnc1_wnc1_sa684"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ras homolog family member A ARH12, ARHA, "ras homolog gene family, member A" HUGO:RHOA HGNC:667 ENTREZ:387 UNIPROT:P61586 GENECARDS:RHOA REACTOME:63078 KEGG:387 ATLASONC:RHOAID42107ch3p21 WIKI:RHOA Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RHOA"/> <bbox w="80.0" h="40.0" x="7328.5" y="1936.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s1003_wnc1_wnc1_csa77" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC2*:CK1_epsilon_*:CTHRC1:DAAM1:DVL*:FZD*:GSK3*:PAR6*:RACK1*:ROR2:RSPO3:SYN4*:VANGL*:WGEF*:WNT*:_beta_-Arrestin2* Identifiers_end References_begin: PCP MODULE s_wnc1_re146:(MAP:survival) Not sure if Rho dissociates when active s_wnc1_re143(MAP:survival): Activated Daam1 is responisble for the inhibition PMID:20351293 Referenes_end References_end</body> </html> </notes> <label text="Fzl/ROR/Wnt/CK1ε/Dvl/Axin/GSK3"/> <bbox w="381.0" h="244.0" x="7300.875" y="1391.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s1004_wnc1_wnc1_sa689"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Complex formation with Fzl-7 and Ror2 PMID:20457807 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="7501.375" y="1418.5"/> <glyph class="unit of information" id="_5837bba4-85c2-48ee-9019-cd0912b3c83d"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7518.875" y="1413.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s1005_wnc1_wnc1_sa690"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>ClasII: Wnt4,-5a,-5b, and -11 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="7489.375" y="1396.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s1006_wnc1_wnc1_sa691"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="7394.875" y="1470.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s1007_wnc1_wnc1_sa692"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="7490.125" y="1468.0"/> <glyph class="state variable" id="_5e9d260e-673d-4d88-89c9-566e64079fd1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7565.125" y="1463.0"/> </glyph> <glyph class="state variable" id="_c49377df-8a15-4499-ab28-aef82400fb65"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7485.125" y="1463.0"/> </glyph> <glyph class="state variable" id="_0a00a935-0d33-4df1-b398-607218231d6b"> <state value="P" variable="S139"/> <bbox w="35.0" h="10.0" x="7552.007" y="1503.0"/> </glyph> <glyph class="state variable" id="_16d3d06f-61b8-4b6b-986e-e0e279f79190"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7485.125" y="1463.0"/> </glyph> <glyph class="state variable" id="_cd7f8cb2-ba3a-47c4-9011-5846239137f0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7565.125" y="1463.0"/> </glyph> <glyph class="state variable" id="_39879ea5-1363-4549-975b-161e035bc48c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7562.2583" y="1463.0"/> </glyph> <glyph class="state variable" id="_c4401c82-4cf8-4545-ae9b-bfc8220b48b1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7565.125" y="1503.0"/> </glyph> <glyph class="state variable" id="_dc16b502-0f3d-497c-bf14-c15d897aa7db"> <state value="P" variable="S142"/> <bbox w="35.0" h="10.0" x="7472.625" y="1502.7223"/> </glyph> <glyph class="state variable" id="_f58ff17b-f1b4-4bd6-888d-6b87dc06b3d5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7485.125" y="1503.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s1007_wnc1_wnc1_sa693"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="7490.125" y="1514.0"/> <glyph class="state variable" id="_a441e143-2380-413e-a555-82aa0aa1b74e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7565.125" y="1509.0"/> </glyph> <glyph class="state variable" id="_9b8bb84d-9428-4f5d-8475-99c09a38876a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7485.125" y="1509.0"/> </glyph> <glyph class="state variable" id="_a60e1323-1d65-4478-832f-66f795513b83"> <state value="P" variable="S139"/> <bbox w="35.0" h="10.0" x="7552.007" y="1549.0"/> </glyph> <glyph class="state variable" id="_ebf3277c-f6a3-4e75-888e-15f0032b2527"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7485.125" y="1509.0"/> </glyph> <glyph class="state variable" id="_cf27b845-f419-4fdc-bcda-043800b9e369"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7565.125" y="1509.0"/> </glyph> <glyph class="state variable" id="_1513ec59-17d6-4b97-92e1-fa691b56b6a4"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7562.2583" y="1509.0"/> </glyph> <glyph class="state variable" id="_5c833249-c690-4f28-9e47-0468f0929ab0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7565.125" y="1549.0"/> </glyph> <glyph class="state variable" id="_e4cfe1e2-ff57-413b-b34d-2eb610647b48"> <state value="P" variable="S142"/> <bbox w="35.0" h="10.0" x="7472.625" y="1548.7223"/> </glyph> <glyph class="state variable" id="_5b363ce2-8a46-4c9d-ac55-9b7496ed1b63"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7485.125" y="1549.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s1008_wnc1_wnc1_sa694"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC2 HGNC:19989 ENTREZ:29882 UNIPROT:Q9UJX6 GENECARDS:ANAPC2 REACTOME:84976 KEGG:29882 ATLASONC:GC_ANAPC2 WIKI:ANAPC2 axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC2 HGNC:19989 ENTREZ:29882 UNIPROT:Q9UJX6 GENECARDS:ANAPC2 REACTOME:84976 KEGG:29882 ATLASONC:GC_ANAPC2 WIKI:ANAPC2 axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="APC2*"/> <bbox w="80.0" h="40.0" x="7588.875" y="1475.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s1009_wnc1_wnc1_sa695"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="7588.875" y="1517.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s1010_wnc1_wnc1_sa696"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: collagen triple helix repeat containing 1 HUGO:CTHRC1 HGNC:18831 ENTREZ:115908 UNIPROT:Q96CG8 GENECARDS:CTHRC1 ATLASONC:CTHRC1ID40193ch8q22 WIKI:CTHRC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTHRC1"/> <bbox w="50.0" h="20.0" x="7532.625" y="1397.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s1011_wnc1_wnc1_sa697"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end Identifiers_begin: Syndecan 4 HUGO:SDC4 HGNC:10661 ENTREZ:6385 UNIPROT:P31431 GENECARDS:SDC4 REACTOME:64234 KEGG:6385 ATLASONC:GC_SDC4 WIKI:SDC4 "syndecan 4 (amphiglycan, ryudocan)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18851840 References_end</body> </html> </notes> <label text="SYN4*"/> <bbox w="80.0" h="50.0" x="7403.625" y="1412.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s1012_wnc1_wnc1_sa698"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="7397.625" y="1518.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s1013_wnc1_wnc1_sa699"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: VANGL planar cell polarity protein 2 "vang (van gogh, Drosophila)-like 2, vang, van gogh-like 2 (Drosophila)", "vang-like 2 (van gogh, Drosophila)" HUGO:VANGL2 HGNC:15511 ENTREZ:57216 UNIPROT:Q9ULK5 GENECARDS:VANGL2 KEGG:57216 ATLASONC:GC_VANGL2 WIKI:VANGL2 VANGL planar cell polarity protein 1 "vang (van gogh, Drosophila)-like 1, vang, van gogh-like 1 (Drosophila)", "vang-like 1 (van gogh, Drosophila)" HUGO:VANGL1 HGNC:15512 ENTREZ:81839 UNIPROT:Q8TAA9 GENECARDS:VANGL1 KEGG:81839 ATLASONC:GC_VANGL1 WIKI:VANGL1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="VANGL*"/> <bbox w="80.0" h="50.0" x="7318.625" y="1412.0"/> <glyph class="state variable" id="_8cce8859-8b66-4051-9a92-ff0644a4765e"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7391.125" y="1407.0"/> </glyph> <glyph class="state variable" id="_6d7229a0-79b9-420a-aecc-608f5a8be0d6"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7391.125" y="1432.0"/> </glyph> <glyph class="state variable" id="_ec475caf-01ec-48c4-8c74-2e6476c45c0a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7311.125" y="1407.0"/> </glyph> <glyph class="state variable" id="_f5b4b013-d0a1-4487-b198-f34b3419de67"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7311.125" y="1432.0"/> </glyph> <glyph class="unit of information" id="_a72972c9-a468-495b-bbc7-211b0a2ea1f5"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7336.125" y="1407.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s1014_wnc1_wnc1_sa700"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 HUGO:GNB2L1 HGNC:4399 ENTREZ:10399 UNIPROT:P63244 GENECARDS:GNB2L1 KEGG:10399 ATLASONC:GNB2L1ID43285ch5q35 WIKI:GNB2L1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RACK1*"/> <bbox w="80.0" h="40.0" x="7308.625" y="1466.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s1015_wnc1_wnc1_sa701"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ROR2"/> <bbox w="80.0" h="50.0" x="7585.375" y="1422.5"/> <glyph class="state variable" id="_eeb0dff4-3245-47d3-8741-e9d2a40b9da3"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7617.875" y="1467.5"/> </glyph> <glyph class="state variable" id="_4934022b-f6b3-4c7b-bd70-ea16e226dff7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7580.375" y="1417.5"/> </glyph> <glyph class="state variable" id="_22c72a91-b86c-4066-9281-746f24ce86cc"> <state value="P" variable="S864"/> <bbox w="35.0" h="10.0" x="7647.875" y="1417.7684"/> </glyph> <glyph class="state variable" id="_6ad03beb-b266-4276-bd29-25e3d5b108d7"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7657.875" y="1467.5"/> </glyph> <glyph class="unit of information" id="_e7dfd74b-b285-40e7-a7ec-fd31ed0beee0"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7602.875" y="1417.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s1016_wnc1_wnc1_sa702"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: par-6 partitioning defective 6 homolog alpha (C. elegans) "par-6 (partitioning defective 6, C.elegans) homolog alpha" HUGO:PARD6A HGNC:15943 ENTREZ:50855 UNIPROT:Q9NPB6 GENECARDS:PARD6A REACTOME:97684 KEGG:50855 ATLASONC:GC_PARD6A WIKI:PARD6A Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PAR6*"/> <bbox w="80.0" h="40.0" x="7312.875" y="1515.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s1017_wnc1_wnc1_sa703"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: R-spondin 3 "R-spondin 3 homolog (Xenopus laevis)", "thrombospondin, type I, domain containing 2", THSD2 HUGO:RSPO3 HGNC:20866 ENTREZ:84870 UNIPROT:Q9BXY4 GENECARDS:RSPO3 KEGG:84870 ATLASONC:GC_RSPO3 WIKI:RSPO3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RSPO3"/> <bbox w="50.0" h="40.0" x="7601.875" y="1559.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s1018_wnc1_wnc1_sa704"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Rho guanine nucleotide exchange factor (GEF) 19 HUGO:ARHGEF19 HGNC:26604 ENTREZ:128272 UNIPROT:Q8IW93 GENECARDS:ARHGEF19 KEGG:128272 ATLASONC:GC_ARHGEF19 WIKI:ARHGEF19 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="WGEF*"/> <bbox w="80.0" h="40.0" x="7405.625" y="1562.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s1019_wnc1_wnc1_sa705"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: dishevelled associated activator of morphogenesis 1 HUGO:DAAM1 HGNC:18142 ENTREZ:23002 UNIPROT:Q9Y4D1 GENECARDS:DAAM1 ATLASONC:GC_DAAM1 WIKI:DAAM1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="DAAM1"/> <bbox w="80.0" h="40.0" x="7491.625" y="1563.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s1024_wnc1_wnc1_csa78" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:RHOA:ROCK* Identifiers_end References_begin: s_wnc1_re141(MAP:survival): Activated Daam1 is responisble for the inhibition PMID:20351293 s_wnc1_re152(MAP:survival): Binding of beta-arrestin to PTEN increases the lipid phosphatase activity of PTEN which converts PIP3 to PIP2. Active ROCK stimulates this complex formation PMID:21642958 ROCK phosphorylates PTEN which is than activated. Activated PTEN reduces the concentration of PIP3 PMID:15793569 PMID:20008297 References_end</body> </html> </notes> <label text="RHOA:ROCK*"/> <bbox w="100.0" h="120.0" x="7735.0" y="1344.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s1025_wnc1_wnc1_sa708"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ras homolog family member A ARH12, ARHA, "ras homolog gene family, member A" HUGO:RHOA HGNC:667 ENTREZ:387 UNIPROT:P61586 GENECARDS:RHOA REACTOME:63078 KEGG:387 ATLASONC:RHOAID42107ch3p21 WIKI:RHOA Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RHOA"/> <bbox w="80.0" h="40.0" x="7742.5625" y="1402.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s1023_wnc1_wnc1_sa709"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Rho-associated, coiled-coil containing protein kinase 1 HUGO:ROCK1 HGNC:10251 ENTREZ:6093 UNIPROT:Q13464 GENECARDS:ROCK1 REACTOME:153167 KEGG:6093 ATLASONC:GC_ROCK1 WIKI:ROCK1 Rho-associated, coiled-coil containing protein kinase 2 HUGO:ROCK2 HGNC:10252 ENTREZ:9475 UNIPROT:O75116 GENECARDS:ROCK2 REACTOME:153173 KEGG:9475 ATLASONC:ROCK2ID43474ch2p25 WIKI:ROCK2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ROCK*"/> <bbox w="80.0" h="40.0" x="7744.9375" y="1356.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s1032_wnc1_wnc1_csa79" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PTEN:_beta_-Arrestin* Identifiers_end References_begin: s_wnc1_re152(MAP:survival): Binding of beta-arrestin to PTEN increases the lipid phosphatase activity of PTEN which converts PIP3 to PIP2. Active ROCK stimulates this complex formation PMID:21642958 ROCK phosphorylates PTEN which is than activated. Activated PTEN reduces the concentration of PIP3 PMID:15793569 PMID:20008297 s_wnc1_re154(MAP:survival): PTEN contains a C2-domain which inhibits cell migration. This inhibition works only when T383 is not phosphorylated PMID:14976311 However, beta-arrestin can also bind PTEN in this C2-region thereby dis-inhibiting migration. References_end</body> </html> </notes> <label text="PTEN:β-Arrestin*"/> <bbox w="110.0" h="120.0" x="7636.0" y="1189.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s1030_wnc1_wnc1_sa713"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homologue BZS, MHAM Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end</body> </html> </notes> <label text="PTEN"/> <bbox w="80.0" h="40.0" x="7649.5" y="1244.0"/> <glyph class="state variable" id="_9dc13e96-0c57-4664-8061-d65b75dcb87f"> <state value="" variable="S380"/> <bbox w="30.0" h="10.0" x="7684.7476" y="1239.0"/> </glyph> <glyph class="state variable" id="_fa0f5591-49d1-4dc6-bbdb-328dd61c1fbb"> <state value="" variable="S370"/> <bbox w="30.0" h="10.0" x="7714.1333" y="1239.0"/> </glyph> <glyph class="state variable" id="_8092b85b-a1cc-4c3a-a807-686ffd5d76b3"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7722.0" y="1279.0"/> </glyph> <glyph class="state variable" id="_8b9bba12-104d-4f2f-ac4c-3626e0e47c9b"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7642.0" y="1279.0"/> </glyph> <glyph class="state variable" id="_294dfda8-748c-4af0-ba38-97badbeaac7e"> <state value="" variable="K289"/> <bbox w="30.0" h="10.0" x="7675.2046" y="1279.0"/> </glyph> <glyph class="state variable" id="_7ec55101-e039-4afd-be2b-389745f75272"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7642.0" y="1239.0"/> </glyph> <glyph class="state variable" id="_e5144cb6-0aa8-49a7-ad0a-97f563e4214c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="7722.0" y="1239.0"/> </glyph> <glyph class="state variable" id="_7c93859b-867c-4423-a550-07f925bd73c7"> <state value="" variable="K13"/> <bbox w="25.0" h="10.0" x="7637.24" y="1279.0"/> </glyph> <glyph class="state variable" id="_bc2ff0c8-f414-4490-ab3b-f8265b691a10"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="7634.5" y="1258.9681"/> </glyph> <glyph class="state variable" id="_32b524ff-3424-4265-be3c-79b40d01893f"> <state value="" variable="T366"/> <bbox w="30.0" h="10.0" x="7714.5" y="1259.0"/> </glyph> <glyph class="state variable" id="_78b11db6-08d2-47a0-8c82-d4d8705c619d"> <state value="" variable="T383"/> <bbox w="30.0" h="10.0" x="7634.5" y="1241.4022"/> </glyph> <glyph class="state variable" id="_50594c14-a2e4-4dee-a1d8-a8d6c4fc2b4b"> <state value="" variable="T382"/> <bbox w="30.0" h="10.0" x="7663.032" y="1239.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s1034_wnc1_wnc1_sa715"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: arrestin, beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 arrestin, beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="β-Arrestin*"/> <bbox w="80.0" h="40.0" x="7646.5" y="1198.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s1048_wnc1_wnc1_csa80" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Ca2+:Calmodulin* Identifiers_end References_begin: s_wnc1_re160:(MAP:survival) PMID:19725819 s_wnc2_re7(MAP:survival): PMID:17593948 PMID:18235236 References_end</body> </html> </notes> <label text="Ca2+:Calmodulin*"/> <bbox w="101.0" h="105.0" x="7604.0" y="564.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s1050_wnc1_wnc1_sa724"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: calmodulin 1 (phosphorylase kinase, delta) CALML2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 2 (phosphorylase kinase, delta) HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 3 (phosphorylase kinase, delta) HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Calmodulin*"/> <bbox w="80.0" h="40.0" x="7615.5" y="578.0"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc1_s1049_wnc1_wnc1_sa725"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Ca2+/Wnt pathway</body> </html> </notes> <label text="Ca2+"/> <bbox w="25.0" h="25.0" x="7641.5" y="621.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s1142_wnc1_wnc1_csa2" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GDP:G_alpha__sub_13q_endsub_*:G_beta_*:G_gamma_*:PAR1* Identifiers_end References_begin: s_wnc1_re7(MAP:survival): PAR1 is activated by cleavage of exodomain at Arg41-Ser42 PMID:14652070 PAR1 can be activated by MMP1 PMID:15707890 References_end</body> </html> </notes> <label text="(GPCR)"/> <bbox w="141.0" h="99.0" x="7214.0" y="249.5"/> <glyph class="macromolecule" id="wnc1_wnc1_s167_wnc1_wnc1_sa12"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: coagulation factor II (thrombin) receptor HUGO:F2R HGNC:3537 ENTREZ:2149 UNIPROT:P25116 GENECARDS:F2R REACTOME:61310 KEGG:2149 ATLASONC:GC_F2R WIKI:F2R Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PAR1*"/> <bbox w="80.0" h="50.0" x="7241.0" y="256.5"/> <glyph class="unit of information" id="_c371bdd0-3fac-455b-b0d6-972ebf75ef2d"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="7258.5" y="251.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s168_wnc1_wnc1_sa22"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Gα13q*"/> <bbox w="50.0" h="20.0" x="7217.5" y="305.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s169_wnc1_wnc1_sa23"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="7267.5" y="305.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s170_wnc1_wnc1_sa24"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="7308.5" y="305.5"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc1_s171_wnc1_wnc1_sa30"> <label text="GDP"/> <bbox w="25.0" h="25.0" x="7228.5" y="322.5"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s1143_wnc1_wnc1_csa3" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GDP:G_alpha__sub_13q_endsub_*:G_beta_*:G_gamma_*:PAR1_sub_TRUNC_endsub_* Identifiers_end References_begin: s_wnc1_re7(MAP:survival): PAR1 is activated by cleavage of exodomain at Arg41-Ser42 PMID:14652070 PAR1 can be activated by MMP1 PMID:15707890 s_wnc1_re1(MAP:survival): PMID:21506126 PAR1 can induce AKT phosphorylation; exact mechanism unknown also wich residues are unknown PMID:17374729 s_wnc1_re8:(MAP:survival) PMID:11694535 s_wnc1_re15:(MAP:survival) PMID:20223821 s_wnc1_re21(MAP:survival): PAR1 silencing leads to increased protein level of activated caspase3 and 9. Increased protein level of Bim, Bax References_end</body> </html> </notes> <label text="(GPCR)"/> <bbox w="146.0" h="104.0" x="7414.0" y="246.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s34_wnc1_wnc1_sa18"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: coagulation factor II (thrombin) receptor HUGO:F2R HGNC:3537 ENTREZ:2149 UNIPROT:P25116 GENECARDS:F2R REACTOME:61310 KEGG:2149 ATLASONC:GC_F2R WIKI:F2R Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Par1' is a cleaved product of the PAR1 upon binding of the ligand References_end</body> </html> </notes> <label text="PAR1TRUNC*"/> <bbox w="80.0" h="40.0" x="7453.0" y="260.0"/> <glyph class="unit of information" id="_ed8d85d3-8e25-4f28-9a9b-d14557794584"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="7468.0" y="255.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s35_wnc1_wnc1_sa25"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Gα13q*"/> <bbox w="50.0" h="20.0" x="7421.5" y="310.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s36_wnc1_wnc1_sa26"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="7471.5" y="310.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s37_wnc1_wnc1_sa27"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="7512.5" y="310.0"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc1_s38_wnc1_wnc1_sa31"> <label text="GDP"/> <bbox w="25.0" h="25.0" x="7432.5" y="325.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s1144_wnc1_wnc1_csa4" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GTP:G_alpha__sub_13q_endsub_*:G_beta_*:G_gamma_*:PAR1_sub_TRUNC_endsub_*:_beta_-Arrestin* Identifiers_end References_begin: s_wnc1_re8:(MAP:survival) PMID:11694535 References_end</body> </html> </notes> <label text="(GPCR)"/> <bbox w="152.0" h="146.0" x="7639.5" y="226.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s40_wnc1_wnc1_sa32"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: coagulation factor II (thrombin) receptor HUGO:F2R HGNC:3537 ENTREZ:2149 UNIPROT:P25116 GENECARDS:F2R REACTOME:61310 KEGG:2149 ATLASONC:GC_F2R WIKI:F2R Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Par1' is a cleaved product of the PAR1 upon binding of the ligand References_end</body> </html> </notes> <label text="PAR1TRUNC*"/> <bbox w="80.0" h="40.0" x="7678.5" y="240.0"/> <glyph class="unit of information" id="_f478898c-ef5f-497b-9601-b3db65bfcc97"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="7693.5" y="235.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s41_wnc1_wnc1_sa33"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein), alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Gα13q*"/> <bbox w="50.0" h="20.0" x="7647.0" y="290.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s42_wnc1_wnc1_sa34"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="7697.0" y="290.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s43_wnc1_wnc1_sa35"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="7738.0" y="290.0"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc1_s44_wnc1_wnc1_sa37"> <label text="GTP"/> <bbox w="25.0" h="25.0" x="7659.5" y="305.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s55_wnc1_wnc1_sa48"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: arrestin, beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 arrestin, beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="β-Arrestin*"/> <bbox w="80.0" h="40.0" x="7686.5" y="312.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s1145_wnc1_wnc1_csa25" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:G_alpha__sub_s_endsub_*:G_beta_*:G_gamma_*:LRP6:PTH Identifiers_end References_begin: s_wnc1_re38:(MAP:survival) PMID:21406690 References_end</body> </html> </notes> <label text="(G-protein/LRP6)"/> <bbox w="159.40625" h="121.84375" x="9022.594" y="250.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s215_wnc1_wnc1_sa152"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LRP6"/> <bbox w="80.0" h="50.0" x="9061.406" y="273.15625"/> <glyph class="state variable" id="_038e79c8-9da7-42f9-8f8a-c1aab90e985b"> <state value="" variable="T1572"/> <bbox w="35.0" h="10.0" x="9043.906" y="293.11642"/> </glyph> <glyph class="state variable" id="_95eece3c-fa1c-4884-9d1d-5e971afcc901"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="9083.938" y="268.15625"/> </glyph> <glyph class="state variable" id="_c230abab-8693-4d6e-8c0f-b0869e62e3ce"> <state value="" variable="S1544"/> <bbox w="35.0" h="10.0" x="9123.906" y="268.4247"/> </glyph> <glyph class="state variable" id="_473ff602-e1b4-4f3d-bff6-497bffc484f1"> <state value="" variable="T1548"/> <bbox w="35.0" h="10.0" x="9123.906" y="306.5934"/> </glyph> <glyph class="state variable" id="_45427581-60b1-4c7a-bf1e-cd6345004dca"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="9123.906" y="268.4247"/> </glyph> <glyph class="state variable" id="_dbee3cb0-beb7-4729-8b39-bd38c2dd3817"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="9044.398" y="268.15625"/> </glyph> <glyph class="unit of information" id="_417c2341-a56c-47b3-8b81-fce2d90d4f6f"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9078.906" y="268.15625"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s216_wnc1_wnc1_sa154"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="9083.219" y="330.96875"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s217_wnc1_wnc1_sa155"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="9124.219" y="330.96875"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s218_wnc1_wnc1_sa164"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: GNAS complex locus GNAS1, "guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1" HUGO:GNAS HGNC:4392 ENTREZ:2778 UNIPROT:O95467 GENECARDS:GNAS KEGG:2778 ATLASONC:GNASID40727ch20q13 WIKI:GNAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Gαs*"/> <bbox w="40.0" h="20.0" x="9042.0" y="330.0"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc1_s219_wnc1_wnc1_sa171"> <label text="PTH"/> <bbox w="70.0" h="25.0" x="9067.0" y="257.5"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s1146_wnc1_wnc1_csa23" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:G_alpha__sub_s_endsub_*:G_beta_*:G_gamma_*:LRP6 Identifiers_end References_begin: s_wnc1_re38:(MAP:survival) PMID:21406690 References_end</body> </html> </notes> <label text="(G-protein/LRP6)"/> <bbox w="158.8125" h="103.6875" x="9222.594" y="268.15625"/> <glyph class="macromolecule" id="wnc1_wnc1_s201_wnc1_wnc1_sa137"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LRP6"/> <bbox w="80.0" h="50.0" x="9261.406" y="273.15625"/> <glyph class="state variable" id="_53c065fe-cde9-40e3-a147-539a42a7379c"> <state value="" variable="T1572"/> <bbox w="35.0" h="10.0" x="9243.906" y="293.11642"/> </glyph> <glyph class="state variable" id="_1ba5ae70-6116-475d-b1f3-ea48f2609685"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="9283.938" y="268.15625"/> </glyph> <glyph class="state variable" id="_c51c2cd5-b890-4e42-828a-698380063cdd"> <state value="" variable="S1544"/> <bbox w="35.0" h="10.0" x="9323.906" y="268.4247"/> </glyph> <glyph class="state variable" id="_77761454-b142-4595-9058-d205508260cb"> <state value="" variable="T1548"/> <bbox w="35.0" h="10.0" x="9323.906" y="306.5934"/> </glyph> <glyph class="state variable" id="_ce332c73-99f2-45f0-92cd-9796466452cd"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="9323.906" y="268.4247"/> </glyph> <glyph class="state variable" id="_2cee67c3-dea5-48a4-91d1-ecabed057c4c"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="9244.398" y="268.15625"/> </glyph> <glyph class="unit of information" id="_0b5cd923-7751-4da0-bade-8286e9e5ea28"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9278.906" y="268.15625"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s202_wnc1_wnc1_sa145"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="9283.219" y="330.96875"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s203_wnc1_wnc1_sa146"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="9324.219" y="330.96875"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s204_wnc1_wnc1_sa162"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: GNAS complex locus GNAS1, "guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1" HUGO:GNAS HGNC:4392 ENTREZ:2778 UNIPROT:O95467 GENECARDS:GNAS KEGG:2778 ATLASONC:GNASID40727ch20q13 WIKI:GNAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Gαs*"/> <bbox w="40.0" h="20.0" x="9242.0" y="330.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s1147_wnc1_wnc1_csa27" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GTP:G_alpha__sub_s_endsub_*:G_beta_*:G_gamma_*:LRP6 Identifiers_end References_begin: s_wnc1_re45:(MAP:survival) PMID:21406690 References_end</body> </html> </notes> <label text="(LRP6_phosph_G-protein)"/> <bbox w="155.0" h="110.0" x="9467.5" y="524.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s211_wnc1_wnc1_sa169"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="9562.5" y="594.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s212_wnc1_wnc1_sa170"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="9522.5" y="594.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s226_wnc1_wnc1_sa178"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LRP6"/> <bbox w="80.0" h="50.0" x="9502.5" y="539.0"/> <glyph class="state variable" id="_6123de3d-e592-4e03-8efc-96c137834d1d"> <state value="" variable="T1572"/> <bbox w="35.0" h="10.0" x="9485.0" y="558.9602"/> </glyph> <glyph class="state variable" id="_ebcdb749-1b73-4ff4-a16b-d7d7f6dced9c"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="9525.032" y="534.0"/> </glyph> <glyph class="state variable" id="_14e1791e-725e-498f-96fc-87725c96978d"> <state value="P" variable="S1544"/> <bbox w="40.0" h="10.0" x="9562.5" y="534.26843"/> </glyph> <glyph class="state variable" id="_ba42cc48-86df-471b-a213-a55089fdf6c7"> <state value="P" variable="T1548"/> <bbox w="40.0" h="10.0" x="9562.5" y="572.4372"/> </glyph> <glyph class="state variable" id="_e09c088f-fabd-4347-9c33-805754421afe"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="9565.0" y="534.26843"/> </glyph> <glyph class="state variable" id="_36581621-ddc2-4002-b907-180b2d8fce53"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="9485.492" y="534.0"/> </glyph> <glyph class="unit of information" id="_2dd24658-c7d3-48b1-b486-3579f78da9ea"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9520.0" y="534.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s227_wnc1_wnc1_sa179"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: GNAS complex locus GNAS1, "guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1" HUGO:GNAS HGNC:4392 ENTREZ:2778 UNIPROT:O95467 GENECARDS:GNAS KEGG:2778 ATLASONC:GNASID40727ch20q13 WIKI:GNAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Gαs*"/> <bbox w="40.0" h="20.0" x="9482.5" y="594.0"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc1_s229_wnc1_wnc1_sa180"> <label text="GTP"/> <bbox w="25.0" h="25.0" x="9480.0" y="571.5"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s1148_wnc1_wnc1_csa26" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GTP:G_alpha__sub_s_endsub_* Identifiers_end References_begin: s_wnc1_re46:(MAP:survival) PMID:21406690 s_wnc1_re40:(MAP:survival) PMID:9228084 References_end</body> </html> </notes> <label text="(Gαs)"/> <bbox w="70.0" h="60.0" x="8927.0" y="470.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s208_wnc1_wnc1_sa167"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: GNAS complex locus GNAS1, "guanine nucleotide binding protein (G protein), alpha stimulating activity polypeptide 1" HUGO:GNAS HGNC:4392 ENTREZ:2778 UNIPROT:O95467 GENECARDS:GNAS KEGG:2778 ATLASONC:GNASID40727ch20q13 WIKI:GNAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Gαs*"/> <bbox w="40.0" h="20.0" x="8952.0" y="490.0"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc1_s210_wnc1_wnc1_sa168"> <label text="GTP"/> <bbox w="25.0" h="25.0" x="8929.5" y="487.5"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s1152_wnc1_wnc1_csa30" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FZD*:GDP:G_alpha_*:G_beta_*:G_gamma_* Identifiers_end References_begin: Ca2+/Wnt MODULE s_wnc1_re49(MAP:survival): PMID:20628572 PMID:12839624 s_wnc1_re62(MAP:survival): Cthrc1 enhances formation of Wnt-Fzl-Ror2 complex PMID:18606138 Syndecan-4 binds to Fzl, Dvl and is required for PCP MODULE. PMID:16604063 PMID:21397842 Vangl-2 forms complex upon binding with Wnt-5 PMID:21316585 ROR2 is associated with Wnt, Fzl and CK1_epsilon PMID:20215527 PPR binds to Fzl in both canonical and non-canonical MODULE PMID:20093472 PMID:21380625 PMID:20579883 References_end</body> </html> </notes> <label text="(Fzl-GPCR)"/> <bbox w="140.0" h="110.0" x="9501.0" y="884.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s299_wnc1_wnc1_sa187"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="9531.0" y="889.0"/> <glyph class="unit of information" id="_d4b0f47b-2f94-439d-8c11-e33b99bc24fd"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9548.5" y="884.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s300_wnc1_wnc1_sa190"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="9557.5" y="936.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s301_wnc1_wnc1_sa191"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="9598.5" y="936.5"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc1_s302_wnc1_wnc1_sa192"> <label text="GDP"/> <bbox w="25.0" h="25.0" x="9518.5" y="951.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s303_wnc1_wnc1_sa200"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Not known which Galpha subunit is coupled ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: guanine nucleotide binding protein (G protein), alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 5Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Gα*"/> <bbox w="40.0" h="20.0" x="9517.0" y="937.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s1153_wnc1_wnc1_csa69" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AP2_alpha*:AP2_beta*:AP2_mu_*:AP2_sigma_* Identifiers_end References_begin: s_wnc1_re112(MAP:survival): Clathrin-mediated endocytosis PMID:21397842 PMID:20947020 PMID:19910923 PCP MODULE splits in Rac1 branch when Dvl is not hyper-phosphorylated PMID:18953287 s_wnc1_re114(MAP:survival): RhoA branch of the PCP -MODULE when Dvl is hyper-phosphorylated by CK_epsilon References_end</body> </html> </notes> <label text="(AP2-complex)"/> <bbox w="202.0" h="120.0" x="8671.5" y="2269.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s787_wnc1_wnc1_sa607"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: adaptor-related protein complex 2, alpha 1 subunit ADTAA, CLAPA1 HUGO:AP2A1 HGNC:561 ENTREZ:160 UNIPROT:O95782 GENECARDS:AP2A1 REACTOME:49262 KEGG:160 ATLASONC:GC_AP2A1 WIKI:AP2A1 adaptor-related protein complex 2, alpha 2 subunit ADTAB, CLAPA2 HUGO:AP2A2 HGNC:562 ENTREZ:161 UNIPROT:O94973 GENECARDS:AP2A2 REACTOME:49264 KEGG:161 WIKI:AP2A2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="AP2_alpha*"/> <bbox w="80.0" h="40.0" x="8687.5" y="2279.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s788_wnc1_wnc1_sa608"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: adaptor-related protein complex 2, beta 1 subunit ADTB2, CLAPB1 HUGO:AP2B1 HGNC:563 ENTREZ:163 UNIPROT:P63010 GENECARDS:AP2B1 REACTOME:49274 KEGG:163 ATLASONC:GC_AP2B1 WIKI:AP2B1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="AP2_beta*"/> <bbox w="80.0" h="40.0" x="8772.5" y="2279.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s789_wnc1_wnc1_sa609"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: adaptor-related protein complex 2, mu 1 subunit CLAPM1 HUGO:AP2M1 HGNC:564 ENTREZ:1173 UNIPROT:Q96CW1 GENECARDS:AP2M1 REACTOME:49286 KEGG:1173 ATLASONC:GC_AP2M1 WIKI:AP2M1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="AP2μ*"/> <bbox w="80.0" h="40.0" x="8687.5" y="2325.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s790_wnc1_wnc1_sa610"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: adaptor-related protein complex 2, sigma 1 subunit CLAPS2 HUGO:AP2S1 HGNC:565 ENTREZ:1175 UNIPROT:P53680 GENECARDS:AP2S1 REACTOME:49294 KEGG:1175 WIKI:AP2S1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="AP2σ*"/> <bbox w="80.0" h="40.0" x="8772.5" y="2325.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc1_s1163_wnc1_wnc1_csa1" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK2_alpha_:CK2_alpha_*:CK2_beta_* Identifiers_end</body> </html> </notes> <label text="(CK2)"/> <bbox w="102.0" h="162.0" x="7946.0" y="583.0"/> <glyph class="macromolecule" id="wnc1_wnc1_s3_wnc1_wnc1_sa3"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 alpha 1 polypeptide HUGO:CSNK2A1 HGNC:2457 ENTREZ:1457 UNIPROT:P68400 GENECARDS:CSNK2A1 REACTOME:201673 KEGG:1457 ATLASONC:GC_CSNK2A1 WIKI:CSNK2A1 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 alpha 1 polypeptide HUGO:CSNK2A1 HGNC:2457 ENTREZ:1457 UNIPROT:P68400 GENECARDS:CSNK2A1 REACTOME:201673 KEGG:1457 ATLASONC:GC_CSNK2A1 WIKI:CSNK2A1 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2α*"/> <bbox w="80.0" h="40.0" x="7957.0" y="597.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s5_wnc1_wnc1_sa4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2β*"/> <bbox w="80.0" h="40.0" x="7959.0" y="681.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc1_s470_wnc1_wnc1_sa350"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 alpha prime polypeptide HUGO:CSNK2A2 HGNC:2459 ENTREZ:1459 UNIPROT:P19784 GENECARDS:CSNK2A2 REACTOME:57879 KEGG:1459 ATLASONC:GC_CSNK2A2 WIKI:CSNK2A2 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 alpha prime polypeptide HUGO:CSNK2A2 HGNC:2459 ENTREZ:1459 UNIPROT:P19784 GENECARDS:CSNK2A2 REACTOME:57879 KEGG:1459 ATLASONC:GC_CSNK2A2 WIKI:CSNK2A2 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2α'*"/> <bbox w="80.0" h="40.0" x="7958.0" y="638.0"/> </glyph> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc1_s268_wnc1_wnc1_sa208" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <label text="Pi"/> <bbox w="25.0" h="25.0" x="9229.5" y="1077.5"/> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc1_s119_wnc1_wnc1_sa104" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Ca2+/Wnt MODULE References_end</body> </html> </notes> <label text="Ca2+"/> <bbox w="25.0" h="25.0" x="7576.5" y="839.5"/> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc1_s123_wnc1_wnc1_sa107" compartmentRef="wnc1_wnc1_c3_wnc1_wnc1_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re27:(MAP:survival) PMID:12747838 References_end</body> </html> </notes> <label text="Ca2+"/> <bbox w="33.0" h="31.0" x="7572.5" y="978.0"/> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s5_wnc1_wnc2_csa1" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:LRP5_6*:WNT* Identifiers_end References_begin: s_wnc2_re1(MAP:survival): Wnt5 can binds to LRP5/6 and in this way, physiologically inhibits non-canonical pathway. In Xenopus and mice. PMID:19056682 s_wnc2_re3(MAP:survival): Binding of Wnt5 and LRP5/6 leads to phosphorylation of Dvl. Most likely the same residues as picture shows same speed of migration on gel compared to Wnt3 stimulation. No phosphorylation of LRP5/6 by Wnt5. This complex formation sequesters away Wnt5 from the non-canonical pathway receptors References_end</body> </html> </notes> <label text="LRP5_6*:WNT*"/> <bbox w="100.0" h="120.0" x="9956.0" y="378.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s9_wnc1_wnc2_sa1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="9966.0" y="429.0"/> <glyph class="state variable" id="_6c852e4f-79c9-450b-ab4f-f3e412cab1a6"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="9948.5" y="448.96017"/> </glyph> <glyph class="state variable" id="_16527f5a-8261-4ff6-98e3-96f52d81e3c5"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="9988.532" y="424.0"/> </glyph> <glyph class="state variable" id="_7ff5a1b7-ee51-4372-affb-6b361a32f2ae"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="10028.5" y="424.26846"/> </glyph> <glyph class="state variable" id="_f9c517b6-1b2a-47da-8dd2-6b19df9229eb"> <state value="" variable="S1496"/> <bbox w="35.0" h="10.0" x="10027.882" y="474.0"/> </glyph> <glyph class="state variable" id="_c344e833-e638-45a1-8b8d-e4cd80ac8a3d"> <state value="" variable="T1530"/> <bbox w="35.0" h="10.0" x="9987.6045" y="474.0"/> </glyph> <glyph class="state variable" id="_e85773aa-c3fe-4a96-8990-befd16bb1ae5"> <state value="" variable="S1533"/> <bbox w="35.0" h="10.0" x="9948.74" y="474.0"/> </glyph> <glyph class="unit of information" id="_198468d2-363b-4c22-9a0a-f5666d467552"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9983.5" y="424.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s10_wnc1_wnc2_sa2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Wnt5 (non-canonical) ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="9985.0" y="412.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s13_wnc1_wnc2_csa2" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DVL*:LRP5_6*:WNT* Identifiers_end References_begin: s_wnc2_re3(MAP:survival): Binding of Wnt5 and LRP5/6 leads to phosphorylation of Dvl. Most likely the same residues as picture shows same speed of migration on gel compared to Wnt3 stimulation. No phosphorylation of LRP5/6 by Wnt5. This complex formation sequesters away Wnt5 from the non-canonical pathway receptors PMID:19056682 References_end</body> </html> </notes> <label text="DVL*:LRP5_6*:WNT*"/> <bbox w="99.0" h="173.0" x="10156.875" y="352.75"/> <glyph class="macromolecule" id="wnc1_wnc2_s14_wnc1_wnc2_sa5"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="10166.875" y="403.75"/> <glyph class="state variable" id="_fea33ef5-d817-4592-aac5-6cc236a6a7ff"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="10149.375" y="423.71017"/> </glyph> <glyph class="state variable" id="_604f29d3-6d58-46f9-9f01-2c0da12d8cef"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="10189.407" y="398.75"/> </glyph> <glyph class="state variable" id="_0ce34b48-5439-4f7b-898b-0c445a79a05c"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="10229.375" y="399.01846"/> </glyph> <glyph class="state variable" id="_deb9e410-2e9f-4269-b596-2d338856d5f0"> <state value="" variable="S1496"/> <bbox w="35.0" h="10.0" x="10228.757" y="448.75"/> </glyph> <glyph class="state variable" id="_f2111cf2-75b5-452d-9ea3-064c0803cc36"> <state value="" variable="T1530"/> <bbox w="35.0" h="10.0" x="10188.4795" y="448.75"/> </glyph> <glyph class="state variable" id="_ba8bab97-71bc-45c9-a431-1e90d4085dbd"> <state value="" variable="S1533"/> <bbox w="35.0" h="10.0" x="10149.615" y="448.75"/> </glyph> <glyph class="unit of information" id="_63eba013-95e4-4343-82b4-557e2c78090e"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="10184.375" y="398.75"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s15_wnc1_wnc2_sa6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Wnt5 (non-canonical) ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="10185.875" y="386.75"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s12_wnc1_wnc2_sa8"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="10165.875" y="455.75"/> <glyph class="state variable" id="_108c2a81-dee8-4c53-8602-114f0e6ab2d9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10240.875" y="450.75"/> </glyph> <glyph class="state variable" id="_aeec3e36-2cf4-461e-a6dc-572307dff1d9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10160.875" y="450.75"/> </glyph> <glyph class="state variable" id="_ef37277e-dfdd-40b0-b274-784b155fb34f"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="10230.257" y="490.75"/> </glyph> <glyph class="state variable" id="_46ae53b8-a0fe-4dab-88cf-9740a94166b3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10160.875" y="450.75"/> </glyph> <glyph class="state variable" id="_eb645cbc-3eca-496e-9a75-1cfc5607f42f"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10238.375" y="450.75"/> </glyph> <glyph class="state variable" id="_7d8121ad-f79c-4dfa-a474-ed9938d68601"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10240.509" y="450.75"/> </glyph> <glyph class="state variable" id="_c5036b2b-1a77-4662-b7a3-7b16aec7ee96"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10238.375" y="490.75"/> </glyph> <glyph class="state variable" id="_f6683169-86f4-4e8f-b972-b03e42136644"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="10150.875" y="490.4723"/> </glyph> <glyph class="state variable" id="_9fc1d36e-e630-4ad3-a228-2f9a205e1032"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10158.375" y="490.75"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s24_wnc1_wnc2_csa3" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CASR:Ca2+ Identifiers_end References_begin: s_wnc2_re4(MAP:survival): PMID:21506126, PMID:21303971 Path to phosphorylation of b-catenin is not completely depicted here. For full paths see AKT-pathway Activated CaSR inhibits phosphorylation of b-catenin, exact mechanism unknown PMID:22094462 References_end</body> </html> </notes> <label text="CASR:Ca2+"/> <bbox w="100.0" h="120.0" x="11079.0" y="400.0"/> <glyph class="simple chemical" id="wnc1_wnc2_s22_wnc1_wnc2_sa15"> <label text="Ca2+"/> <bbox w="25.0" h="25.0" x="11115.75" y="414.25"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s23_wnc1_wnc2_sa16"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: calcium-sensing receptor HHC, HHC1, "hypocalciuric hypercalcemia 1" HUGO:CASR HGNC:1514 ENTREZ:846 UNIPROT:P41180 GENECARDS:CASR REACTOME:51416 KEGG:846 ATLASONC:GC_CASR WIKI:CASR Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CASR"/> <bbox w="80.0" h="50.0" x="11088.25" y="433.75"/> <glyph class="unit of information" id="_50576c8e-3004-4e96-a276-cfd8446a4427"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="11105.75" y="428.75"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s30_wnc1_wnc2_csa5" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Ca2+:Calmodulin* Identifiers_end</body> </html> </notes> <label text="Ca2+:Calmodulin*"/> <bbox w="101.0" h="99.0" x="10502.0" y="503.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s31_wnc1_wnc2_sa21"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: calmodulin 1 (phosphorylase kinase, delta) CALML2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 2 (phosphorylase kinase, delta) HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 3 (phosphorylase kinase, delta) HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Calmodulin*"/> <bbox w="80.0" h="40.0" x="10514.0" y="514.0"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc2_s32_wnc1_wnc2_sa22"> <label text="Ca2+"/> <bbox w="25.0" h="25.0" x="10542.5" y="556.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s41_wnc1_wnc2_csa7" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PPP3CB_sub_trunc_endsub_*:PPP3R* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Constitutively active PMID:17662023, PMID:17593948, PMID:14627704 s_wnc2_re9(MAP:survival): Calcineurin can be proteolysed which results in a truncated form of the catalytic subunit A. The truncated form is constitutively active and irreversible and does not require calcium and calmodulin for activation. PMID:17593948, PMID:14627704 s_wnc2_re26:(MAP:survival) PMID:15036616, PMID:14741051 s_wnc2_re66:(MAP:survival) PMID:11796223 s_wnc2_re77:(MAP:survival) PMID:16648474 References_end</body> </html> </notes> <label text="PPP3CBtrunc*:PPP3R*"/> <bbox w="100.0" h="120.0" x="10258.0" y="715.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s39_wnc1_wnc2_sa30"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, catalytic subunit, beta isozyme CALNB, "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)" HUGO:PPP3CB HGNC:9315 ENTREZ:5532 UNIPROT:P16298 GENECARDS:PPP3CB REACTOME:403037 KEGG:5532 ATLASONC:GC_PPP3CB WIKI:PPP3CB Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3CBtrunc*"/> <bbox w="80.0" h="40.0" x="10268.0" y="724.0"/> <glyph class="unit of information" id="_8c33448d-f3e5-456a-aa5b-e6f84c143937"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10283.0" y="719.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s40_wnc1_wnc2_sa31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, regulatory subunit B, alpha "protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform" HUGO:PPP3R1 HGNC:9317 ENTREZ:5534 UNIPROT:P63098 GENECARDS:PPP3R1 REACTOME:51292 KEGG:5534 ATLASONC:GC_PPP3R1 WIKI:PPP3R1 protein phosphatase 3, regulatory subunit B, beta HUGO:PPP3PR2 GENECARDS:PPP3PR2 WIKI:PPP3PR2 HUGO:PPP3R2 HGNC:9318 ENTREZ:5535 UNIPROT:Q96LZ3 GENECARDS:PPP3R2 KEGG:5535 ATLASONC:GC_PPP3R2 WIKI:PPP3R2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3R*"/> <bbox w="80.0" h="40.0" x="10268.0" y="767.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s54_wnc1_wnc2_csa9" compartmentRef="wnc1_wnc2_c3_wnc1_wnc2_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAX:BID_sub_TRUNC_endsub_* Identifiers_end References_begin: s_wnc2_re14:(MAP:survival) PMID:20008353, PMID:20709625, PMID:21738214 References_end</body> </html> </notes> <label text="BAX:BIDTRUNC*"/> <bbox w="100.0" h="120.0" x="10221.0" y="1153.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s56_wnc1_wnc2_sa41"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 GENECARDS:BAX REACTOME:50715 KEGG:581 ATLASONC:BAXID128ch19q13 WIKI:BAX Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20709625 References_end Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 GENECARDS:BAX REACTOME:50715 KEGG:581 ATLASONC:BAXID128ch19q13 WIKI:BAX Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20709625 References_end</body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="10229.5" y="1163.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s55_wnc1_wnc2_sa43"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: BH3 interacting domain death agonist HUGO:BID HGNC:1050 ENTREZ:637 UNIPROT:P55957 GENECARDS:BID REACTOME:50826 KEGG:637 ATLASONC:GC_BID WIKI:BID Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BIDTRUNC*"/> <bbox w="80.0" h="40.0" x="10231.5" y="1213.0"/> <glyph class="unit of information" id="_5f6f20db-cbfc-4a47-a313-9eeab1e2d335"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10246.5" y="1208.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s61_wnc1_wnc2_csa10" compartmentRef="wnc1_wnc2_c3_wnc1_wnc2_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAX:BCL2-XL* Identifiers_end References_begin: s_wnc2_re19:(MAP:survival) PMID:21486225 s_wnc2_re22(MAP:survival): PMID:14681224, PMID:14612448 However, the mechanism in which truncated Bax increases apoptosis remains controversial. PMID:20008353 References_end</body> </html> </notes> <label text="BAX:BCL2-XL*"/> <bbox w="100.0" h="120.0" x="10100.0" y="1151.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s63_wnc1_wnc2_sa49"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: BCL2-like 1BCL2-associated agonist of cell death HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 GENECARDS:BCL2L1 REACTOME:50772 KEGG:598 ATLASONC:BCL2L1ID129ch20q11 WIKI:BCL2L1 BCL2-like 1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:10949026 PMID:18097445 References_end Identifiers_begin: BCL2-like 1BCL2-associated agonist of cell death HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 GENECARDS:BCL2L1 REACTOME:50772 KEGG:598 ATLASONC:BCL2L1ID129ch20q11 WIKI:BCL2L1 BCL2-like 1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:10949026 PMID:18097445 References_end</body> </html> </notes> <label text="BCL2-XL*"/> <bbox w="80.0" h="40.0" x="10110.5" y="1160.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s62_wnc1_wnc2_sa50"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 GENECARDS:BAX REACTOME:50715 KEGG:581 ATLASONC:BAXID128ch19q13 WIKI:BAX Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20709625 References_end Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 GENECARDS:BAX REACTOME:50715 KEGG:581 ATLASONC:BAXID128ch19q13 WIKI:BAX Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20709625 References_end</body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="10110.5" y="1204.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s64_wnc1_wnc2_csa11" compartmentRef="wnc1_wnc2_c3_wnc1_wnc2_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAX_sub_TRUNC_endsub_*:BCL2-XL* Identifiers_end References_begin: s_wnc2_re22(MAP:survival): PMID:14681224, PMID:14612448 However, the mechanism in which truncated Bax increases apoptosis remains controversial. PMID:20008353 References_end</body> </html> </notes> <label text="BAXTRUNC*:BCL2-XL*"/> <bbox w="100.0" h="120.0" x="9925.0" y="1151.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s66_wnc1_wnc2_sa51"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: BCL2-like 1BCL2-associated agonist of cell death HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 GENECARDS:BCL2L1 REACTOME:50772 KEGG:598 ATLASONC:BCL2L1ID129ch20q11 WIKI:BCL2L1 BCL2-like 1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:10949026 PMID:18097445 References_end Identifiers_begin: BCL2-like 1BCL2-associated agonist of cell death HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 GENECARDS:BCL2L1 REACTOME:50772 KEGG:598 ATLASONC:BCL2L1ID129ch20q11 WIKI:BCL2L1 BCL2-like 1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:10949026 PMID:18097445 References_end</body> </html> </notes> <label text="BCL2-XL*"/> <bbox w="80.0" h="40.0" x="9934.5" y="1163.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s65_wnc1_wnc2_sa52"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 GENECARDS:BAX REACTOME:50715 KEGG:581 ATLASONC:BAXID128ch19q13 WIKI:BAX Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BAXTRUNC*"/> <bbox w="80.0" h="40.0" x="9935.5" y="1204.0"/> <glyph class="unit of information" id="_0119b48b-759c-48ed-9312-56888eb6b860"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="9950.5" y="1199.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s71_wnc1_wnc2_csa12" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Calpain*:Calpastatin* Identifiers_end References_begin: s_wnc2_re25(MAP:survival): Formation is dependent of Ca2+ concentration. It is believed that Ca2+ concentration regulates activity of Calpastatin. PMID:12684003 References_end</body> </html> </notes> <label text="Calpain*:Calpastatin*"/> <bbox w="100.0" h="120.0" x="10594.0" y="759.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s73_wnc1_wnc2_sa57"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: calpain 1, (mu/I) large subunit HUGO:CAPN1 HGNC:1476 ENTREZ:823 UNIPROT:P07384 GENECARDS:CAPN1 KEGG:823 ATLASONC:GC_CAPN1 WIKI:CAPN1 calpain 2, (m/II) large subunit HUGO:CAPN2 HGNC:1479 ENTREZ:824 UNIPROT:P17655 GENECARDS:CAPN2 KEGG:824 ATLASONC:GC_CAPN2 WIKI:CAPN2 calpain 3, (p94) HUGO:CAPN3 HGNC:1480 ENTREZ:825 UNIPROT:P20807 GENECARDS:CAPN3 KEGG:825 ATLASONC:GC_CAPN3 WIKI:CAPN3 calpain 5 HUGO:CAPN5 HGNC:1482 ENTREZ:726 UNIPROT:O15484 GENECARDS:CAPN5 KEGG:726 ATLASONC:GC_CAPN5 WIKI:CAPN5 calpain 6 HUGO:CAPN6 HGNC:1483 ENTREZ:827 UNIPROT:Q9Y6Q1 GENECARDS:CAPN6 KEGG:827 ATLASONC:GC_CAPN6 WIKI:CAPN6 calpain 7 HUGO:CAPN7 HGNC:1484 ENTREZ:23473 UNIPROT:Q9Y6W3 GENECARDS:CAPN7 KEGG:23473 WIKI:CAPN7 calpain 8 HUGO:CAPN8 HGNC:1485 ENTREZ:388743 UNIPROT:A6NHC0 GENECARDS:CAPN8 KEGG:388743 WIKI:CAPN8 calpain 9 HUGO:CAPN9 HGNC:1486 ENTREZ:10753 UNIPROT:O14815 GENECARDS:CAPN9 KEGG:10753 ATLASONC:GC_CAPN9 WIKI:CAPN9 calpain 10 HUGO:CAPN10 HGNC:1477 ENTREZ:11132 UNIPROT:Q9HC96 GENECARDS:CAPN10 KEGG:11132 ATLASONC:GC_CAPN10 WIKI:CAPN10 calpain 11 HUGO:CAPN11 HGNC:1478 ENTREZ:11131 UNIPROT:Q9UMQ6 GENECARDS:CAPN11 KEGG:11131 WIKI:CAPN11 calpain 12 HUGO:CAPN12 HGNC:13249 ENTREZ:147968 UNIPROT:Q6ZSI9 GENECARDS:CAPN12 WIKI:CAPN12 calpain 13 HUGO:CAPN13 HGNC:16663 ENTREZ:92291 UNIPROT:Q6MZZ7 GENECARDS:CAPN13 WIKI:CAPN13 calpain 14 HUGO:CAPN14 HGNC:16664 ENTREZ:440854 UNIPROT:A8MX76 GENECARDS:CAPN14 WIKI:CAPN14 calpain 15 HUGO:SOLH HGNC:11182 ENTREZ:6650 UNIPROT:O75808 GENECARDS:SOLH KEGG:6650 WIKI:SOLH calpain, small subunit 1 HUGO:CAPNS1 HGNC:1481 ENTREZ:826 UNIPROT:P04632 GENECARDS:CAPNS1 KEGG:826 ATLASONC:GC_CAPNS1 WIKI:CAPNS1 calpain, small subunit 2 HUGO:CAPNS2 HGNC:16371 ENTREZ:84290 UNIPROT:Q96L46 GENECARDS:CAPNS2 WIKI:CAPNS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Calpain*"/> <bbox w="80.0" h="40.0" x="10605.5" y="767.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s72_wnc1_wnc2_sa58"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: calpastatin HUGO:CAST HGNC:1515 ENTREZ:831 UNIPROT:P20810 GENECARDS:CAST KEGG:10849 ATLASONC:GC_CAST WIKI:CAST Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Calpastatin*"/> <bbox w="80.0" h="40.0" x="10605.5" y="815.0"/> <glyph class="state variable" id="_0b656dd8-c508-4278-95b4-a05dc10b35d2"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10598.0" y="810.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s77_wnc1_wnc2_csa14" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:BAD Identifiers_end References_begin: s_wnc2_re26:(MAP:survival) PMID:15036616, PMID:14741051 s_wnc2_re30:(MAP:survival) PMID:22088220 References_end</body> </html> </notes> <label text="14-3-3*:BAD"/> <bbox w="96.0" h="126.0" x="10177.5" y="1555.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s84_wnc1_wnc2_sa63"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 References_end Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end</body> </html> Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end</body> </html> </notes> <label text="BAD"/> <bbox w="80.0" h="40.0" x="10186.5" y="1604.0"/> <glyph class="state variable" id="_1b29fd1c-65bd-466b-bd2b-8e2e37b965fb"> <state value="" variable="S112"/> <bbox w="30.0" h="10.0" x="10171.992" y="1599.0"/> </glyph> <glyph class="state variable" id="_20fd1084-456b-4afd-a4bf-bbb0604beada"> <state value="" variable="S136"/> <bbox w="30.0" h="10.0" x="10251.5" y="1599.2147"/> </glyph> <glyph class="state variable" id="_bd11b76d-39b7-485c-bb1e-6340e0bd7b4b"> <state value="" variable="S155"/> <bbox w="30.0" h="10.0" x="10250.882" y="1639.0"/> </glyph> <glyph class="state variable" id="_d3b7c042-5a77-40cf-b4c5-ebd6882a3e78"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10181.5" y="1619.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s76_wnc1_wnc2_sa65"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="10186.5" y="1563.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s79_wnc1_wnc2_csa13" compartmentRef="wnc1_wnc2_c3_wnc1_wnc2_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:BAD Identifiers_end</body> </html> </notes> <label text="14-3-3*:BAD"/> <bbox w="96.0" h="124.0" x="10356.0" y="1329.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s87_wnc1_wnc2_sa60"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 References_end Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end</body> </html> Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end</body> </html> </notes> <label text="BAD"/> <bbox w="80.0" h="40.0" x="10365.0" y="1378.0"/> <glyph class="state variable" id="_0beb1175-8ac2-489f-9e88-99451f33b4ec"> <state value="" variable="S112"/> <bbox w="30.0" h="10.0" x="10350.492" y="1373.0"/> </glyph> <glyph class="state variable" id="_b19a3d9f-fcf4-41e9-b1ac-b855d24f22b8"> <state value="" variable="S136"/> <bbox w="30.0" h="10.0" x="10430.0" y="1373.2147"/> </glyph> <glyph class="state variable" id="_72ebf925-792b-401d-a4ea-2f29ba5f4736"> <state value="" variable="S155"/> <bbox w="30.0" h="10.0" x="10429.382" y="1413.0"/> </glyph> <glyph class="state variable" id="_e2d8ecc2-017c-4ab8-a603-624ba9b7576c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10360.0" y="1393.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s88_wnc1_wnc2_sa62"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="10365.0" y="1337.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s86_wnc1_wnc2_csa15" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:BAD Identifiers_end References_begin: s_wnc2_re26:(MAP:survival) PMID:15036616, PMID:14741051 References_end</body> </html> </notes> <label text="14-3-3*:BAD"/> <bbox w="96.0" h="124.0" x="10356.5" y="1556.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s82_wnc1_wnc2_sa67"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 References_end Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end</body> </html> Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end</body> </html> </notes> <label text="BAD"/> <bbox w="80.0" h="40.0" x="10365.5" y="1605.0"/> <glyph class="state variable" id="_6041fcec-ab60-4fc5-a4f3-107a6dcc67ac"> <state value="" variable="S112"/> <bbox w="30.0" h="10.0" x="10350.992" y="1600.0"/> </glyph> <glyph class="state variable" id="_845be67e-119b-4cba-9c51-f1a6024ca6d7"> <state value="" variable="S136"/> <bbox w="30.0" h="10.0" x="10430.5" y="1600.2147"/> </glyph> <glyph class="state variable" id="_61a818db-e4c4-4626-879c-7551875453c6"> <state value="" variable="S155"/> <bbox w="30.0" h="10.0" x="10429.882" y="1640.0"/> </glyph> <glyph class="state variable" id="_4638ecfd-2318-474a-a02b-b176a553dd73"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10360.5" y="1620.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s81_wnc1_wnc2_sa68"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="10365.5" y="1564.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s95_wnc1_wnc2_csa16" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FOXO1:PPP3CB_sub_trunc_endsub_*:PPP3R* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Constitutively active PMID:17662023, PMID:17593948, PMID:14627704 References_end</body> </html> </notes> <label text="FOXO1:PPP3CBtrunc*:PPP3R*"/> <bbox w="103.0" h="175.0" x="10750.5" y="992.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s100_wnc1_wnc2_sa75"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, catalytic subunit, beta isozyme CALNB, "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)" HUGO:PPP3CB HGNC:9315 ENTREZ:5532 UNIPROT:P16298 GENECARDS:PPP3CB REACTOME:403037 KEGG:5532 ATLASONC:GC_PPP3CB WIKI:PPP3CB Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3CBtrunc*"/> <bbox w="80.0" h="40.0" x="10760.5" y="1001.0"/> <glyph class="unit of information" id="_5a4a9878-786e-404f-9d0c-757448aa8f77"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10775.5" y="996.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s101_wnc1_wnc2_sa76"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, regulatory subunit B, alpha "protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform" HUGO:PPP3R1 HGNC:9317 ENTREZ:5534 UNIPROT:P63098 GENECARDS:PPP3R1 REACTOME:51292 KEGG:5534 ATLASONC:GC_PPP3R1 WIKI:PPP3R1 protein phosphatase 3, regulatory subunit B, beta HUGO:PPP3PR2 GENECARDS:PPP3PR2 WIKI:PPP3PR2 HUGO:PPP3R2 HGNC:9318 ENTREZ:5535 UNIPROT:Q96LZ3 GENECARDS:PPP3R2 KEGG:5535 ATLASONC:GC_PPP3R2 WIKI:PPP3R2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3R*"/> <bbox w="80.0" h="40.0" x="10760.5" y="1044.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s102_wnc1_wnc2_sa77"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end</body> </html> </notes> <label text="FOXO1"/> <bbox w="80.0" h="40.0" x="10763.25" y="1092.0"/> <glyph class="state variable" id="_c370c7c8-65f7-46fd-96ed-568f1607fd64"> <state value="" variable="S329"/> <bbox w="30.0" h="10.0" x="10748.25" y="1126.7223"/> </glyph> <glyph class="state variable" id="_84d8df99-513a-4aaf-a812-fdc4248eb418"> <state value="" variable="S319"/> <bbox w="30.0" h="10.0" x="10828.25" y="1087.0"/> </glyph> <glyph class="state variable" id="_790f56b2-51b8-44db-ac74-aa8b0e5a0cb9"> <state value="" variable="S325"/> <bbox w="30.0" h="10.0" x="10788.154" y="1127.0"/> </glyph> <glyph class="state variable" id="_b7cd0e2f-87e5-4359-a2e7-78f2ffcc0a2f"> <state value="" variable="S322"/> <bbox w="30.0" h="10.0" x="10827.632" y="1127.0"/> </glyph> <glyph class="state variable" id="_ff2f61b6-60b7-4832-82c4-f727c2f71f43"> <state value="" variable="S256"/> <bbox w="30.0" h="10.0" x="10788.282" y="1087.0"/> </glyph> <glyph class="state variable" id="_127ee444-901b-463d-93b7-d230712d4eca"> <state value="" variable="T24"/> <bbox w="25.0" h="10.0" x="10751.242" y="1087.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s99_wnc1_wnc2_csa17" compartmentRef="wnc1_wnc2_c4_wnc1_wnc2_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FOXO1:PPP3CB_sub_trunc_endsub_*:PPP3R* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Constitutively active PMID:17662023, PMID:17593948, PMID:14627704 References_end</body> </html> </notes> <label text="FOXO1:PPP3CBtrunc*:PPP3R*"/> <bbox w="103.0" h="175.0" x="10751.75" y="1739.5"/> <glyph class="macromolecule" id="wnc1_wnc2_s96_wnc1_wnc2_sa78"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, catalytic subunit, beta isozyme CALNB, "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)" HUGO:PPP3CB HGNC:9315 ENTREZ:5532 UNIPROT:P16298 GENECARDS:PPP3CB REACTOME:403037 KEGG:5532 ATLASONC:GC_PPP3CB WIKI:PPP3CB Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3CBtrunc*"/> <bbox w="80.0" h="40.0" x="10761.75" y="1748.5"/> <glyph class="unit of information" id="_c65dd44a-654f-4288-9054-1b8ea567a5f5"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10776.75" y="1743.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s97_wnc1_wnc2_sa79"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, regulatory subunit B, alpha "protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform" HUGO:PPP3R1 HGNC:9317 ENTREZ:5534 UNIPROT:P63098 GENECARDS:PPP3R1 REACTOME:51292 KEGG:5534 ATLASONC:GC_PPP3R1 WIKI:PPP3R1 protein phosphatase 3, regulatory subunit B, beta HUGO:PPP3PR2 GENECARDS:PPP3PR2 WIKI:PPP3PR2 HUGO:PPP3R2 HGNC:9318 ENTREZ:5535 UNIPROT:Q96LZ3 GENECARDS:PPP3R2 KEGG:5535 ATLASONC:GC_PPP3R2 WIKI:PPP3R2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3R*"/> <bbox w="80.0" h="40.0" x="10761.75" y="1791.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s98_wnc1_wnc2_sa80"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end</body> </html> </notes> <label text="FOXO1"/> <bbox w="80.0" h="40.0" x="10764.5" y="1839.5"/> <glyph class="state variable" id="_60245fdf-ad71-4292-b742-3c51525e64e2"> <state value="" variable="S329"/> <bbox w="30.0" h="10.0" x="10749.5" y="1874.2223"/> </glyph> <glyph class="state variable" id="_1956edb2-ea49-481c-b0bf-2474def8b552"> <state value="" variable="S319"/> <bbox w="30.0" h="10.0" x="10829.5" y="1834.5"/> </glyph> <glyph class="state variable" id="_9c55ae40-284a-4ff8-b5ef-9837a4805bdc"> <state value="" variable="S325"/> <bbox w="30.0" h="10.0" x="10789.404" y="1874.5"/> </glyph> <glyph class="state variable" id="_2edc1468-e1f7-4907-a756-446ae6b1f3ea"> <state value="" variable="S322"/> <bbox w="30.0" h="10.0" x="10828.882" y="1874.5"/> </glyph> <glyph class="state variable" id="_20f56de7-adba-4371-be6f-1cf591e3a250"> <state value="" variable="S256"/> <bbox w="30.0" h="10.0" x="10789.532" y="1834.5"/> </glyph> <glyph class="state variable" id="_c7ce4100-f2cf-4132-adf0-cce1a9414c45"> <state value="" variable="T24"/> <bbox w="25.0" h="10.0" x="10752.492" y="1834.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s105_wnc1_wnc2_csa18" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NFAT*:PPP3CB_sub_trunc_endsub_*:PPP3R* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Constitutively active PMID:17662023, PMID:17593948, PMID:14627704 s_wnc2_re82(MAP:survival): Most likely, the complex will dissociates PMID:16648474 References_end</body> </html> </notes> <label text="NFAT*:PPP3CBtrunc*:PPP3R*"/> <bbox w="103.0" h="175.0" x="10927.5" y="639.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s106_wnc1_wnc2_sa83"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, catalytic subunit, beta isozyme CALNB, "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)" HUGO:PPP3CB HGNC:9315 ENTREZ:5532 UNIPROT:P16298 GENECARDS:PPP3CB REACTOME:403037 KEGG:5532 ATLASONC:GC_PPP3CB WIKI:PPP3CB Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3CBtrunc*"/> <bbox w="80.0" h="40.0" x="10937.5" y="648.0"/> <glyph class="unit of information" id="_3c5aaa09-78aa-4cd4-895f-d725da005f3d"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10952.5" y="643.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s107_wnc1_wnc2_sa84"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, regulatory subunit B, alpha "protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform" HUGO:PPP3R1 HGNC:9317 ENTREZ:5534 UNIPROT:P63098 GENECARDS:PPP3R1 REACTOME:51292 KEGG:5534 ATLASONC:GC_PPP3R1 WIKI:PPP3R1 protein phosphatase 3, regulatory subunit B, beta HUGO:PPP3PR2 GENECARDS:PPP3PR2 WIKI:PPP3PR2 HUGO:PPP3R2 HGNC:9318 ENTREZ:5535 UNIPROT:Q96LZ3 GENECARDS:PPP3R2 KEGG:5535 ATLASONC:GC_PPP3R2 WIKI:PPP3R2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3R*"/> <bbox w="80.0" h="40.0" x="10937.5" y="691.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s108_wnc1_wnc2_sa87"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="10936.5" y="744.0"/> <glyph class="state variable" id="_fd527646-1daa-4078-b520-388b8f0019ea"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11009.0" y="767.2843"/> </glyph> <glyph class="state variable" id="_e22d3234-0d09-4d5c-b42f-a07195cf736b"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11009.0" y="779.0"/> </glyph> <glyph class="state variable" id="_061a1cbf-9f04-415b-92b4-6b1a2f80d8b8"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10985.568" y="779.0"/> </glyph> <glyph class="state variable" id="_6f608811-0aec-4e65-957d-44d82b8a3bcf"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10929.0" y="739.0"/> </glyph> <glyph class="state variable" id="_ea8ba10d-488d-49ab-8af6-5d032ba42eec"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10952.432" y="739.0"/> </glyph> <glyph class="state variable" id="_ca32e341-c784-4b22-9173-2d2085a7a65f"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10969.0" y="739.0"/> </glyph> <glyph class="state variable" id="_2c911863-6290-4b08-a1d3-9ecf8d76af32"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10931.5" y="759.0"/> </glyph> <glyph class="state variable" id="_e6024070-617f-4b79-af2b-0cc20a0ebc3a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10985.568" y="739.0"/> </glyph> <glyph class="state variable" id="_d67c0c9c-1e22-41e9-8568-f2faf40fdd05"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11009.0" y="739.0"/> </glyph> <glyph class="state variable" id="_22d9c379-3117-4abd-95b4-f9c5e6dd7ffd"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11009.0" y="750.7157"/> </glyph> <glyph class="state variable" id="_1b525394-1147-4841-acf1-fbe487ccd22c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11009.0" y="759.0"/> </glyph> <glyph class="state variable" id="_226ca295-3c3e-4bfd-9c68-485c5892e7e6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10931.5" y="739.0"/> </glyph> <glyph class="state variable" id="_359d87ef-0d9a-49ea-8c32-4ee5d2050112"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10931.5" y="750.7157"/> </glyph> <glyph class="state variable" id="_33441a27-b9b4-4dfb-b5f3-ec3513910a2b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10931.5" y="767.2843"/> </glyph> <glyph class="state variable" id="_517363c9-91f8-40f3-a4c5-5e2aaee0475f"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="10935.156" y="779.0"/> </glyph> <glyph class="state variable" id="_55daaeeb-7051-4812-9863-a70d7bc13285"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="10955.356" y="779.0"/> </glyph> <glyph class="state variable" id="_b2b605d0-0660-458a-a3e1-6870de7fd7f0"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10969.0" y="779.0"/> </glyph> <glyph class="state variable" id="_454e75a9-05b2-43e6-baa7-d79926910069"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10952.432" y="779.0"/> </glyph> <glyph class="state variable" id="_56dea97e-ccba-4dc5-b7b7-6a1c06827583"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10929.0" y="779.0"/> </glyph> <glyph class="state variable" id="_ac99d010-fd6b-4b9f-9355-9b80633d830e"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10929.0" y="759.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s109_wnc1_wnc2_csa19" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NFAT*:PPP3CB_sub_trunc_endsub_*:PPP3R* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Constitutively active PMID:17662023, PMID:17593948, PMID:14627704 s_wnc2_re45(MAP:survival): Tubulin-alpha binds both NFAT and KPNB1 after dephosphorylation of NFAT. PMID:21278340 TNPO1 is a transport protein that helps in the import of proteins into the nucleus. Although it has been described with associated with NRON, it is most likely that it binds first to NFAT complex, making this complex ready for import, then NRON can bind to this complex to hinder the import of the complex PMID:21709260 s_wnc2_re82(MAP:survival): Most likely, the complex will dissociates PMID:16648474 References_end</body> </html> </notes> <label text="NFAT*:PPP3CBtrunc*:PPP3R*"/> <bbox w="103.0" h="175.0" x="10927.5" y="926.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s114_wnc1_wnc2_sa85"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, catalytic subunit, beta isozyme CALNB, "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)" HUGO:PPP3CB HGNC:9315 ENTREZ:5532 UNIPROT:P16298 GENECARDS:PPP3CB REACTOME:403037 KEGG:5532 ATLASONC:GC_PPP3CB WIKI:PPP3CB Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3CBtrunc*"/> <bbox w="80.0" h="40.0" x="10937.5" y="935.0"/> <glyph class="unit of information" id="_05672b55-6dbd-4eb8-a790-35c10a0f63a4"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10952.5" y="930.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s115_wnc1_wnc2_sa86"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, regulatory subunit B, alpha "protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform" HUGO:PPP3R1 HGNC:9317 ENTREZ:5534 UNIPROT:P63098 GENECARDS:PPP3R1 REACTOME:51292 KEGG:5534 ATLASONC:GC_PPP3R1 WIKI:PPP3R1 protein phosphatase 3, regulatory subunit B, beta HUGO:PPP3PR2 GENECARDS:PPP3PR2 WIKI:PPP3PR2 HUGO:PPP3R2 HGNC:9318 ENTREZ:5535 UNIPROT:Q96LZ3 GENECARDS:PPP3R2 KEGG:5535 ATLASONC:GC_PPP3R2 WIKI:PPP3R2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3R*"/> <bbox w="80.0" h="40.0" x="10937.5" y="978.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s116_wnc1_wnc2_sa88"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="10938.5" y="1031.0"/> <glyph class="state variable" id="_81529f5b-24fd-471c-b931-3c713ad04b4d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11013.5" y="1054.2843"/> </glyph> <glyph class="state variable" id="_86f22b1d-8066-4b07-bca1-f8952ca12913"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11013.5" y="1066.0"/> </glyph> <glyph class="state variable" id="_b1e35084-0c5c-4c55-a9f4-9330f98fd75c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10990.068" y="1066.0"/> </glyph> <glyph class="state variable" id="_bf2fee80-c3f9-4c76-83a6-28ec43c71fc0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10933.5" y="1026.0"/> </glyph> <glyph class="state variable" id="_80f97893-e74d-4cc0-8007-1eeac3f76b49"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10956.932" y="1026.0"/> </glyph> <glyph class="state variable" id="_95ccedb4-91ec-4096-ac0f-6e6767aa0fbd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10973.5" y="1026.0"/> </glyph> <glyph class="state variable" id="_8b015993-3516-442e-b1df-a0549ee59ef7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10933.5" y="1046.0"/> </glyph> <glyph class="state variable" id="_abc8ef6e-5c4d-4c6b-9382-5df2b4414888"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10990.068" y="1026.0"/> </glyph> <glyph class="state variable" id="_bf1b4fa2-953c-44c9-99e7-465be6a63f87"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11013.5" y="1026.0"/> </glyph> <glyph class="state variable" id="_f6dd47ee-4909-4273-941c-3dfd12735947"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11013.5" y="1037.7157"/> </glyph> <glyph class="state variable" id="_32bcbe1c-9892-4b4b-89e8-0ebd18470ec7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11013.5" y="1046.0"/> </glyph> <glyph class="state variable" id="_2436b698-bc5a-44b7-a84f-dbf08ce4965e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10933.5" y="1026.0"/> </glyph> <glyph class="state variable" id="_6a75a57b-b230-4ce3-b82d-2b2f6202a41c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10933.5" y="1037.7157"/> </glyph> <glyph class="state variable" id="_09668d94-bbad-4f04-8fae-ecf24d2dcb7e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10933.5" y="1054.2843"/> </glyph> <glyph class="state variable" id="_54ac9794-c1e5-4018-9a24-31329dc0dc2f"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="10937.156" y="1066.0"/> </glyph> <glyph class="state variable" id="_c1b40cd7-07dd-49da-a4cf-88dee1d77547"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="10957.356" y="1066.0"/> </glyph> <glyph class="state variable" id="_084bff81-341a-471c-8c4f-ce07fae53bc2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10973.5" y="1066.0"/> </glyph> <glyph class="state variable" id="_52a8fd1a-0a56-40f3-a21a-b48d8c83e444"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10956.932" y="1066.0"/> </glyph> <glyph class="state variable" id="_7de65da5-accb-4115-b696-6b5da4924464"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10933.5" y="1066.0"/> </glyph> <glyph class="state variable" id="_f45f74ba-f634-4dd6-89db-9633a03027fa"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10933.5" y="1046.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s156_wnc1_wnc2_csa20" compartmentRef="wnc1_wnc2_c4_wnc1_wnc2_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:KPNB1:NFAT*:PPP3CB_sub_trunc_endsub_*:PPP3R*:Tubulin-_alpha_* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Constitutively active PMID:17662023, PMID:17593948, PMID:14627704 References_end</body> </html> </notes> <label text="KPNB1:NFAT*:PPP3CBtrunc*:PPP3R*:Tubulin-α*"/> <bbox w="111.0" h="281.0" x="10917.5" y="1739.5"/> <glyph class="macromolecule" id="wnc1_wnc2_s110_wnc1_wnc2_sa89"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, catalytic subunit, beta isozyme CALNB, "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)" HUGO:PPP3CB HGNC:9315 ENTREZ:5532 UNIPROT:P16298 GENECARDS:PPP3CB REACTOME:403037 KEGG:5532 ATLASONC:GC_PPP3CB WIKI:PPP3CB Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3CBtrunc*"/> <bbox w="80.0" h="40.0" x="10927.5" y="1748.5"/> <glyph class="unit of information" id="_d0572f20-c922-441b-a8c1-232a8d52ec77"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10942.5" y="1743.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s111_wnc1_wnc2_sa90"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, regulatory subunit B, alpha "protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform" HUGO:PPP3R1 HGNC:9317 ENTREZ:5534 UNIPROT:P63098 GENECARDS:PPP3R1 REACTOME:51292 KEGG:5534 ATLASONC:GC_PPP3R1 WIKI:PPP3R1 protein phosphatase 3, regulatory subunit B, beta HUGO:PPP3PR2 GENECARDS:PPP3PR2 WIKI:PPP3PR2 HUGO:PPP3R2 HGNC:9318 ENTREZ:5535 UNIPROT:Q96LZ3 GENECARDS:PPP3R2 KEGG:5535 ATLASONC:GC_PPP3R2 WIKI:PPP3R2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3R*"/> <bbox w="80.0" h="40.0" x="10927.5" y="1791.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s112_wnc1_wnc2_sa91"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="10928.5" y="1844.5"/> <glyph class="state variable" id="_efb3c194-f3ff-4665-a2b0-d124553d369e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11003.5" y="1867.7843"/> </glyph> <glyph class="state variable" id="_25beebcf-ac8c-434c-a626-3383791eec2c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11003.5" y="1879.5"/> </glyph> <glyph class="state variable" id="_01d49b1f-4481-4ae5-b893-67a1db96a175"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10980.068" y="1879.5"/> </glyph> <glyph class="state variable" id="_871963b0-1895-4ff7-a51a-e75ef7ae28ca"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10923.5" y="1839.5"/> </glyph> <glyph class="state variable" id="_0ca00706-f45d-4758-acd3-52a5522ddc1b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10946.932" y="1839.5"/> </glyph> <glyph class="state variable" id="_8d428f59-f94a-4a3c-adf9-f988e57b6683"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10963.5" y="1839.5"/> </glyph> <glyph class="state variable" id="_9788477e-39f5-4da8-8d5e-e51a3ceada3e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10923.5" y="1859.5"/> </glyph> <glyph class="state variable" id="_e9f845b1-d909-4679-b7c8-1f99d31eef98"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10980.068" y="1839.5"/> </glyph> <glyph class="state variable" id="_a2fc6bdb-8e31-4100-8655-2b7a79852dcc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11003.5" y="1839.5"/> </glyph> <glyph class="state variable" id="_51742719-5d63-4db7-959b-a66ff5d36814"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11003.5" y="1851.2157"/> </glyph> <glyph class="state variable" id="_df5a854f-4560-4e52-b0d7-8ef9dc8cbfc4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11003.5" y="1859.5"/> </glyph> <glyph class="state variable" id="_9d62d5ae-acd5-4941-8217-dcbaa457081e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10923.5" y="1839.5"/> </glyph> <glyph class="state variable" id="_2aac6fce-8b40-4e47-ae38-9cd8fb38fc4c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10923.5" y="1851.2157"/> </glyph> <glyph class="state variable" id="_4e1a9a70-1a16-4774-93cb-0eb970b87037"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10923.5" y="1867.7843"/> </glyph> <glyph class="state variable" id="_0d28814b-6ab3-466d-b365-e1ba5d207724"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="10927.156" y="1879.5"/> </glyph> <glyph class="state variable" id="_e51f7f93-37d7-420d-8f24-fe1fd13ed670"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="10947.356" y="1879.5"/> </glyph> <glyph class="state variable" id="_6986cb03-34b5-4f82-9887-468eeef447d1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10963.5" y="1879.5"/> </glyph> <glyph class="state variable" id="_d16bf025-0fa3-48cf-a65f-ca29767288ee"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10946.932" y="1879.5"/> </glyph> <glyph class="state variable" id="_3f1e80d4-82cd-40a4-87be-63a454eee909"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10923.5" y="1879.5"/> </glyph> <glyph class="state variable" id="_b898f09f-e184-4e50-bf52-0d32b94c595d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10923.5" y="1859.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s155_wnc1_wnc2_sa123"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: karyopherin (importin) beta 1 HUGO:KPNB1 HGNC:6400 ENTREZ:3837 UNIPROT:Q14974 GENECARDS:KPNB1 REACTOME:57343 KEGG:3837 ATLASONC:GC_KPNB1 WIKI:KPNB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="KPNB1"/> <bbox w="80.0" h="40.0" x="10927.5" y="1893.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s154_wnc1_wnc2_sa124"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tubulin, alpha 1a HUGO:TUBA1A HGNC:20766 ENTREZ:7846 UNIPROT:Q71U36 GENECARDS:TUBA1A REACTOME:191692 KEGG:7846 ATLASONC:GC_TUBA1A WIKI:TUBA1A SwissProt: Q71U36 tubulin, alpha 1b HUGO:TUBA1B HGNC:18809 ENTREZ:10376 UNIPROT:P68363 GENECARDS:TUBA1B REACTOME:191693 KEGG:10376 ATLASONC:GC_TUBA1B WIKI:TUBA1B SwissProt: P68363 tubulin, alpha 1c HUGO:TUBA1C HGNC:20768 ENTREZ:84790 UNIPROT:Q9BQE3 GENECARDS:TUBA1C REACTOME:65667 KEGG:84790 ATLASONC:GC_TUBA1C WIKI:TUBA1C SwissProt: Q9BQE3 tubulin, alpha 3c HUGO:TUBA3C HGNC:12408 ENTREZ:7278 UNIPROT:Q13748 GENECARDS:TUBA3C REACTOME:154750 KEGG:7278 WIKI:TUBA3C SwissProt: Q13748 tubulin, alpha 3d HUGO:TUBA3D HGNC:24071 ENTREZ:113457 UNIPROT:Q13748 GENECARDS:TUBA3D REACTOME:154750 KEGG:113457 WIKI:TUBA3D tubulin, alpha 3e HUGO:TUBA3E HGNC:20765 ENTREZ:112714 UNIPROT:Q6PEY2 GENECARDS:TUBA3E WIKI:TUBA3E SwissProt: Q6PEY2 tubulin, alpha 4a HUGO:TUBA4A HGNC:12407 ENTREZ:7277 UNIPROT:P68366 GENECARDS:TUBA4A REACTOME:191690 KEGG:7277 ATLASONC:GC_TUBA4A WIKI:TUBA4A SwissProt: P68366 tubulin, alpha 8 HUGO:TUBA8 HGNC:12410 ENTREZ:51807 UNIPROT:Q9NY65 GENECARDS:TUBA8 KEGG:51807 WIKI:TUBA8 SwissProt: Q9NY65 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Tubulin-α*"/> <bbox w="80.0" h="40.0" x="10927.5" y="1935.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s163_wnc1_wnc2_csa27" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK1_epsilon_*:DYRK*:GSK3*:IQGAP*:NFAT*:NRON Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:21709260 s_wnc2_re46(MAP:survival): Upon Ca2+ activation the NRON-NFAT complex dissociates. References_end</body> </html> </notes> <label text="CK1ε*:DYRK*:GSK3*:IQGAP*:NFAT*:NRON"/> <bbox w="200.0" h="176.0" x="11517.0" y="497.0"/> <glyph class="nucleic acid feature" id="wnc1_wnc2_s164_wnc1_wnc2_sa106"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: non-protein coding RNA, repressor of NFAT HUGO:NRON HGNC:37079 ENTREZ:641373 GENECARDS:NRON KEGG:641373 WIKI:NRON Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="NRON"/> <bbox w="90.0" h="25.0" x="11526.0" y="523.5"/> <glyph class="unit of information" id="_bf7176e0-9ad4-4f72-a075-a2951897bd53"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="11561.0" y="518.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s135_wnc1_wnc2_sa107"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: IQ motif containing GTPase activating protein 1 HUGO:IQGAP1 HGNC:6110 ENTREZ:8826 UNIPROT:P46940 GENECARDS:IQGAP1 REACTOME:381664 KEGG:8826 ATLASONC:GC_IQGAP1 WIKI:IQGAP1 IQ motif containing GTPase activating protein 2 HUGO:IQGAP2 HGNC:6111 ENTREZ:10788 UNIPROT:Q13576 GENECARDS:IQGAP2 ATLASONC:GC_IQGAP2 WIKI:IQGAP2 IQ motif containing GTPase activating protein 3 HUGO:IQGAP3 HGNC:20669 ENTREZ:128239 UNIPROT:Q86VI3 GENECARDS:IQGAP3 WIKI:IQGAP3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="IQGAP*"/> <bbox w="80.0" h="40.0" x="11526.0" y="605.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s160_wnc1_wnc2_sa135"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="11620.5" y="507.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s161_wnc1_wnc2_sa136"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="11620.5" y="606.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s162_wnc1_wnc2_sa137"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A HUGO:DYRK1A HGNC:3091 ENTREZ:1859 UNIPROT:Q13627 GENECARDS:DYRK1A REACTOME:54046 KEGG:1859 ATLASONC:DYRK1AID43234ch21q22 WIKI:DYRK1A 1859 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B HUGO:DYRK1B HGNC:3092 ENTREZ:9149 UNIPROT:Q9Y463 GENECARDS:DYRK1B KEGG:9149 ATLASONC:DYRK1BID43235ch19q13 WIKI:DYRK1B 9149 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 HUGO:DYRK2 HGNC:3093 ENTREZ:8445 UNIPROT:Q92630 GENECARDS:DYRK2 ATLASONC:GC_DYRK2 WIKI:DYRK2 8445 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 HUGO:DYRK3 HGNC:3094 ENTREZ:8444 UNIPROT:O43781 GENECARDS:DYRK3 KEGG:8444 ATLASONC:GC_DYRK3 WIKI:DYRK3 8444 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 HUGO:DYRK4 HGNC:3095 ENTREZ:8798 UNIPROT:Q9NR20 GENECARDS:DYRK4 ATLASONC:GC_DYRK4 WIKI:DYRK4 8798 DYRK, DYRK1, MNBH Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:9932450 PMID:19685005 References_end Identifiers_begin: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A HUGO:DYRK1A HGNC:3091 ENTREZ:1859 UNIPROT:Q13627 GENECARDS:DYRK1A REACTOME:54046 KEGG:1859 ATLASONC:DYRK1AID43234ch21q22 WIKI:DYRK1A 1859 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B HUGO:DYRK1B HGNC:3092 ENTREZ:9149 UNIPROT:Q9Y463 GENECARDS:DYRK1B KEGG:9149 ATLASONC:DYRK1BID43235ch19q13 WIKI:DYRK1B 9149 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 HUGO:DYRK2 HGNC:3093 ENTREZ:8445 UNIPROT:Q92630 GENECARDS:DYRK2 ATLASONC:GC_DYRK2 WIKI:DYRK2 8445 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 HUGO:DYRK3 HGNC:3094 ENTREZ:8444 UNIPROT:O43781 GENECARDS:DYRK3 KEGG:8444 ATLASONC:GC_DYRK3 WIKI:DYRK3 8444 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 HUGO:DYRK4 HGNC:3095 ENTREZ:8798 UNIPROT:Q9NR20 GENECARDS:DYRK4 ATLASONC:GC_DYRK4 WIKI:DYRK4 8798 DYRK, DYRK1, MNBH Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:9932450 PMID:19685005 References_end</body> </html> </notes> <label text="DYRK*"/> <bbox w="80.0" h="40.0" x="11526.0" y="558.0"/> <glyph class="state variable" id="_20676e73-6f91-442c-aaae-abc0f9f73462"> <state value="" variable="T308"/> <bbox w="30.0" h="10.0" x="11511.492" y="553.0"/> </glyph> <glyph class="state variable" id="_7f2afbd7-b117-45b0-9a03-f9afd8017f78"> <state value="" variable="T309"/> <bbox w="30.0" h="10.0" x="11551.032" y="553.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s165_wnc1_wnc2_sa138"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="11621.0" y="558.0"/> <glyph class="state variable" id="_4a8e31dd-f323-47c0-ad40-d8a50250b315"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11693.5" y="581.2843"/> </glyph> <glyph class="state variable" id="_8a69b3e9-9bab-4907-9f4d-d7f60e3f9ba9"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11693.5" y="593.0"/> </glyph> <glyph class="state variable" id="_e78e940f-239a-4277-a4f5-774144d1069a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11670.068" y="593.0"/> </glyph> <glyph class="state variable" id="_5ab7686e-19f4-465b-91f2-1e93d878205a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11613.5" y="553.0"/> </glyph> <glyph class="state variable" id="_1363a754-5b65-4cd3-a515-0ff7868d39c7"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11636.932" y="553.0"/> </glyph> <glyph class="state variable" id="_cbcaf714-6c07-4224-8007-c2ddf0563951"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11653.5" y="553.0"/> </glyph> <glyph class="state variable" id="_ce7cbff8-8095-489c-a359-f6fc4920db4e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11616.0" y="573.0"/> </glyph> <glyph class="state variable" id="_68b33f46-c7e8-438c-af44-0ea3cb3ef4aa"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11670.068" y="553.0"/> </glyph> <glyph class="state variable" id="_2a3a4153-b922-45c5-8f31-4e4bae1e1aca"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11693.5" y="553.0"/> </glyph> <glyph class="state variable" id="_cc87cf32-372e-478f-ac1a-de0ae2ff8d56"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11693.5" y="564.7157"/> </glyph> <glyph class="state variable" id="_e1e8f5bb-daaa-47c6-b97d-32e499c94455"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11693.5" y="573.0"/> </glyph> <glyph class="state variable" id="_454003cb-3c13-44b3-8479-d153fb51c379"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11616.0" y="553.0"/> </glyph> <glyph class="state variable" id="_cbc486b3-4f30-4f9d-8176-5cea99415cee"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11616.0" y="564.7157"/> </glyph> <glyph class="state variable" id="_f0d3c50f-5788-4303-822b-306788eeb917"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11616.0" y="581.2843"/> </glyph> <glyph class="state variable" id="_bc7615a3-7de5-4924-a82b-cb5dc2b8b2da"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="11619.656" y="593.0"/> </glyph> <glyph class="state variable" id="_67a17acf-cf3c-43e9-b902-f33d9a0d58ae"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="11639.856" y="593.0"/> </glyph> <glyph class="state variable" id="_59446ad8-6750-400d-9e66-9dfc3d150b1a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11653.5" y="593.0"/> </glyph> <glyph class="state variable" id="_3017a351-c754-45d2-98a7-180837cd7c10"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11636.932" y="593.0"/> </glyph> <glyph class="state variable" id="_2891f84f-976b-4f7a-87ac-613888cba2bb"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11613.5" y="593.0"/> </glyph> <glyph class="state variable" id="_36d90cdc-c98f-437f-a779-e76378237ef2"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11613.5" y="573.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s185_wnc1_wnc2_csa26" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CSE1L:Ca2+:Calmodulin*:KPNB1:LRRK2:NFAT*:NRON:PPP3CB:PPP3R*:TNPO1:Tubulin-_alpha_* Identifiers_end References_begin: s_wnc2_re47(MAP:survival): LRKK2 mediates binding of NFAT to NRON and other components, but this is independent of its kinase activity and independent of the phosphorylation status of NFAT PMID:21983832 References_end</body> </html> </notes> <label text="CSE1L:Ca2+:Calmodulin*:KPNB1:LRRK2:NFAT*:NRON:PPP3CB:PPP3R*:TNPO1:Tubulin-α*"/> <bbox w="179.0" h="327.0" x="11692.5" y="859.5"/> <glyph class="macromolecule" id="wnc1_wnc2_s173_wnc1_wnc2_sa128"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="11702.0" y="1019.5"/> <glyph class="state variable" id="_a5a4050f-27c4-4a34-9f47-26023773345d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11777.0" y="1042.7843"/> </glyph> <glyph class="state variable" id="_3b9c9925-2354-4a27-95ac-050c1b4ce62a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11777.0" y="1054.5"/> </glyph> <glyph class="state variable" id="_ee7d7a77-ac24-42f9-85a3-41ae0789a15c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11753.568" y="1054.5"/> </glyph> <glyph class="state variable" id="_8c971cb6-3fb5-443e-91a1-cde3c11542f1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11697.0" y="1014.5"/> </glyph> <glyph class="state variable" id="_1bab3006-1e32-4333-a919-350f606e928b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11720.432" y="1014.5"/> </glyph> <glyph class="state variable" id="_5286e053-1b2c-4d2a-a50e-4dd70bd02739"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11737.0" y="1014.5"/> </glyph> <glyph class="state variable" id="_91271578-dc9c-4b86-8565-353c6ccfb397"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11697.0" y="1034.5"/> </glyph> <glyph class="state variable" id="_2f346bed-25e0-435c-9a80-6f5075b1b204"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11753.568" y="1014.5"/> </glyph> <glyph class="state variable" id="_d1704ab8-4565-416e-ac0d-1d33df2b7fc8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11777.0" y="1014.5"/> </glyph> <glyph class="state variable" id="_5990d6be-8e2c-4862-b548-2308b1c29f89"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11777.0" y="1026.2157"/> </glyph> <glyph class="state variable" id="_a91c3cf4-f6e4-4d72-823e-544faa54c16f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11777.0" y="1034.5"/> </glyph> <glyph class="state variable" id="_9ca72232-d50d-4ead-9882-964ba1d22d51"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11697.0" y="1014.5"/> </glyph> <glyph class="state variable" id="_220137d9-d4f7-4eb9-95c3-6d0424204344"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11697.0" y="1026.2157"/> </glyph> <glyph class="state variable" id="_3dfff72a-3616-4acf-b09b-9a6e95cc3e40"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11697.0" y="1042.7843"/> </glyph> <glyph class="state variable" id="_870eccbb-0e9b-4215-93d1-03e72887d9c0"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="11700.656" y="1054.5"/> </glyph> <glyph class="state variable" id="_a4abf4cb-e147-4de9-8799-183f7952f67e"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="11720.856" y="1054.5"/> </glyph> <glyph class="state variable" id="_9d6afd81-960e-4284-92e4-4888f1fae6b7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11737.0" y="1054.5"/> </glyph> <glyph class="state variable" id="_050bd4dd-7210-4ce4-956c-6b0f8d557ff8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11720.432" y="1054.5"/> </glyph> <glyph class="state variable" id="_91e5ebe0-74b8-4918-8ed5-2d42d96c50b3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11697.0" y="1054.5"/> </glyph> <glyph class="state variable" id="_08a0ba9b-5345-419f-94cf-da1c1b85bf13"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11697.0" y="1034.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s174_wnc1_wnc2_sa129"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, catalytic subunit, beta isozyme CALNB, "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)" HUGO:PPP3CB HGNC:9315 ENTREZ:5532 UNIPROT:P16298 GENECARDS:PPP3CB REACTOME:403037 KEGG:5532 ATLASONC:GC_PPP3CB WIKI:PPP3CB Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3CB"/> <bbox w="80.0" h="40.0" x="11702.0" y="866.0"/> <glyph class="state variable" id="_c27f999e-6879-4a40-9f3f-32d199e8872e"> <state value="" variable="S197"/> <bbox w="30.0" h="10.0" x="11767.0" y="861.2148"/> </glyph> <glyph class="state variable" id="_bc10b493-4270-4d22-a8f7-d9ab3060350f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11697.0" y="861.0"/> </glyph> <glyph class="state variable" id="_55766085-5246-4278-8b07-09f096fa0046"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11697.0" y="881.0"/> </glyph> <glyph class="state variable" id="_11f4a68e-df0a-408c-b33e-41f841279645"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11697.0" y="901.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s175_wnc1_wnc2_sa130"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, regulatory subunit B, alpha "protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform" HUGO:PPP3R1 HGNC:9317 ENTREZ:5534 UNIPROT:P63098 GENECARDS:PPP3R1 REACTOME:51292 KEGG:5534 ATLASONC:GC_PPP3R1 WIKI:PPP3R1 protein phosphatase 3, regulatory subunit B, beta HUGO:PPP3PR2 GENECARDS:PPP3PR2 WIKI:PPP3PR2 HUGO:PPP3R2 HGNC:9318 ENTREZ:5535 UNIPROT:Q96LZ3 GENECARDS:PPP3R2 KEGG:5535 ATLASONC:GC_PPP3R2 WIKI:PPP3R2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3R*"/> <bbox w="80.0" h="40.0" x="11702.0" y="909.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s176_wnc1_wnc2_sa131"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: calmodulin 1 (phosphorylase kinase, delta) CALML2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 2 (phosphorylase kinase, delta) HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 3 (phosphorylase kinase, delta) HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Calmodulin*"/> <bbox w="80.0" h="40.0" x="11702.0" y="951.5"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc2_s177_wnc1_wnc2_sa132"> <label text="Ca2+"/> <bbox w="25.0" h="25.0" x="11729.75" y="992.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s178_wnc1_wnc2_sa133"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: karyopherin (importin) beta 1 HUGO:KPNB1 HGNC:6400 ENTREZ:3837 UNIPROT:Q14974 GENECARDS:KPNB1 REACTOME:57343 KEGG:3837 ATLASONC:GC_KPNB1 WIKI:KPNB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="KPNB1"/> <bbox w="80.0" h="40.0" x="11785.75" y="868.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s179_wnc1_wnc2_sa134"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tubulin, alpha 1a HUGO:TUBA1A HGNC:20766 ENTREZ:7846 UNIPROT:Q71U36 GENECARDS:TUBA1A REACTOME:191692 KEGG:7846 ATLASONC:GC_TUBA1A WIKI:TUBA1A SwissProt: Q71U36 tubulin, alpha 1b HUGO:TUBA1B HGNC:18809 ENTREZ:10376 UNIPROT:P68363 GENECARDS:TUBA1B REACTOME:191693 KEGG:10376 ATLASONC:GC_TUBA1B WIKI:TUBA1B SwissProt: P68363 tubulin, alpha 1c HUGO:TUBA1C HGNC:20768 ENTREZ:84790 UNIPROT:Q9BQE3 GENECARDS:TUBA1C REACTOME:65667 KEGG:84790 ATLASONC:GC_TUBA1C WIKI:TUBA1C SwissProt: Q9BQE3 tubulin, alpha 3c HUGO:TUBA3C HGNC:12408 ENTREZ:7278 UNIPROT:Q13748 GENECARDS:TUBA3C REACTOME:154750 KEGG:7278 WIKI:TUBA3C SwissProt: Q13748 tubulin, alpha 3d HUGO:TUBA3D HGNC:24071 ENTREZ:113457 UNIPROT:Q13748 GENECARDS:TUBA3D REACTOME:154750 KEGG:113457 WIKI:TUBA3D tubulin, alpha 3e HUGO:TUBA3E HGNC:20765 ENTREZ:112714 UNIPROT:Q6PEY2 GENECARDS:TUBA3E WIKI:TUBA3E SwissProt: Q6PEY2 tubulin, alpha 4a HUGO:TUBA4A HGNC:12407 ENTREZ:7277 UNIPROT:P68366 GENECARDS:TUBA4A REACTOME:191690 KEGG:7277 ATLASONC:GC_TUBA4A WIKI:TUBA4A SwissProt: P68366 tubulin, alpha 8 HUGO:TUBA8 HGNC:12410 ENTREZ:51807 UNIPROT:Q9NY65 GENECARDS:TUBA8 KEGG:51807 WIKI:TUBA8 SwissProt: Q9NY65 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Tubulin-α*"/> <bbox w="80.0" h="40.0" x="11785.75" y="910.5"/> </glyph> <glyph class="nucleic acid feature" id="wnc1_wnc2_s182_wnc1_wnc2_sa148"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: non-protein coding RNA, repressor of NFAT HUGO:NRON HGNC:37079 ENTREZ:641373 GENECARDS:NRON KEGG:641373 WIKI:NRON Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="NRON"/> <bbox w="90.0" h="25.0" x="11779.625" y="957.0"/> <glyph class="unit of information" id="_0eb40a1c-77f6-4e57-9649-218092f483b0"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="11814.625" y="952.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s180_wnc1_wnc2_sa149"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CSE1 chromosome segregation 1-like (yeast) "chromosome segregation 1 (yeast homolog)-like" HUGO:CSE1L HGNC:2431 ENTREZ:1434 UNIPROT:P55060 GENECARDS:CSE1L KEGG:1434 ATLASONC:CSE1LID40159ch20q13 WIKI:CSE1L Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CSE1L"/> <bbox w="80.0" h="40.0" x="11784.375" y="985.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s181_wnc1_wnc2_sa150"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transportin 1 "karyopherin (importin) beta 2", KPNB2 HUGO:TNPO1 HGNC:6401 ENTREZ:3842 UNIPROT:Q92973 GENECARDS:TNPO1 REACTOME:57345 KEGG:3842 ATLASONC:GC_TNPO1 WIKI:TNPO1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TNPO1"/> <bbox w="80.0" h="40.0" x="11784.375" y="1029.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s184_wnc1_wnc2_sa152"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: leucine-rich repeat kinase 2 HUGO:LRRK2 HGNC:18618 ENTREZ:120892 UNIPROT:Q5S007 GENECARDS:LRRK2 KEGG:120892 ATLASONC:GC_LRRK2 WIKI:LRRK2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LRRK2"/> <bbox w="80.0" h="40.0" x="11700.5" y="1071.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s206_wnc1_wnc2_csa30" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CAMK2*:Ca2+:Calmodulin* Identifiers_end</body> </html> </notes> <label text="CAMK2*:Ca2+:Calmodulin*"/> <bbox w="101.0" h="133.0" x="10595.0" y="902.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s201_wnc1_wnc2_sa163"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: calmodulin 1 (phosphorylase kinase, delta) CALML2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 2 (phosphorylase kinase, delta) HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 3 (phosphorylase kinase, delta) HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Calmodulin*"/> <bbox w="80.0" h="40.0" x="10606.0" y="907.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s202_wnc1_wnc2_sa164"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: calcium/calmodulin-dependent protein kinase II alpha "calcium/calmodulin-dependent protein kinase (CaM kinase) II alpha", CAMKA HUGO:CAMK2A HGNC:1460 ENTREZ:815 UNIPROT:Q9UQM7 GENECARDS:CAMK2A REACTOME:57903 KEGG:815 ATLASONC:GC_CAMK2A WIKI:CAMK2A calcium/calmodulin-dependent protein kinase II beta "calcium/calmodulin-dependent protein kinase (CaM kinase) II beta", CAMKB HUGO:CAMK2B HGNC:1461 ENTREZ:816 UNIPROT:Q13554 GENECARDS:CAMK2B REACTOME:57905 KEGG:816 ATLASONC:GC_CAMK2B WIKI:CAMK2B calcium/calmodulin-dependent protein kinase II delta HUGO:CAMK2D HGNC:1462 ENTREZ:817 UNIPROT:Q13557 GENECARDS:CAMK2D REACTOME:57907 KEGG:817 ATLASONC:GC_CAMK2D WIKI:CAMK2D calcium/calmodulin-dependent protein kinase II gamma HUGO:CAMK2G HGNC:1463 ENTREZ:818 UNIPROT:Q13555 GENECARDS:CAMK2G REACTOME:57909 KEGG:818 ATLASONC:GC_CAMK2G WIKI:CAMK2G calcium/calmodulin-dependent protein kinase II beta"calcium/calmodulin-dependent protein kinase (CaM kinase) II beta", CAMKB HUGO:CAMK2B HGNC:1461 ENTREZ:816 UNIPROT:Q13554 GENECARDS:CAMK2B REACTOME:57905 KEGG:816 ATLASONC:GC_CAMK2B WIKI:CAMK2B HUGO:CAMK2D HGNC:1462 ENTREZ:817 UNIPROT:Q13557 GENECARDS:CAMK2D REACTOME:57907 KEGG:817 ATLASONC:GC_CAMK2D WIKI:CAMK2D "calcium/calmodulin-dependent protein kinase (CaM kinase) II delta", CAMKD "calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma", CAMKG Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CAMK2*"/> <bbox w="80.0" h="40.0" x="10606.0" y="950.0"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc2_s204_wnc1_wnc2_sa165"> <label text="Ca2+"/> <bbox w="25.0" h="25.0" x="10633.5" y="991.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s207_wnc1_wnc2_csa28" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CSE1L:KPNB1:LRRK2:NFAT*:NRON:PPP3CB_sub_trunc_endsub_*:PPP3R*:TNPO1:Tubulin-_alpha_* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Constitutively active PMID:17662023, PMID:17593948, PMID:14627704 s_wnc2_re48:(MAP:survival) PMID:21709260 References_end</body> </html> </notes> <label text="CSE1L:KPNB1:LRRK2:NFAT*:NRON:PPP3CBtrunc*:PPP3R*:TNPO1:Tubulin-α*"/> <bbox w="201.0" h="281.0" x="11673.875" y="1263.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s192_wnc1_wnc2_sa145"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CSE1 chromosome segregation 1-like (yeast) "chromosome segregation 1 (yeast homolog)-like" HUGO:CSE1L HGNC:2431 ENTREZ:1434 UNIPROT:P55060 GENECARDS:CSE1L KEGG:1434 ATLASONC:CSE1LID40159ch20q13 WIKI:CSE1L Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CSE1L"/> <bbox w="80.0" h="40.0" x="11687.25" y="1303.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s193_wnc1_wnc2_sa146"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transportin 1 "karyopherin (importin) beta 2", KPNB2 HUGO:TNPO1 HGNC:6401 ENTREZ:3842 UNIPROT:Q92973 GENECARDS:TNPO1 REACTOME:57345 KEGG:3842 ATLASONC:GC_TNPO1 WIKI:TNPO1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TNPO1"/> <bbox w="80.0" h="40.0" x="11687.25" y="1347.0"/> </glyph> <glyph class="nucleic acid feature" id="wnc1_wnc2_s194_wnc1_wnc2_sa147"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: non-protein coding RNA, repressor of NFAT HUGO:NRON HGNC:37079 ENTREZ:641373 GENECARDS:NRON KEGG:641373 WIKI:NRON Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="NRON"/> <bbox w="90.0" h="25.0" x="11682.5" y="1275.0"/> <glyph class="unit of information" id="_073b6c2d-7636-43e0-a855-c44961196a88"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="11717.5" y="1270.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s187_wnc1_wnc2_sa153"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, catalytic subunit, beta isozyme CALNB, "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)" HUGO:PPP3CB HGNC:9315 ENTREZ:5532 UNIPROT:P16298 GENECARDS:PPP3CB REACTOME:403037 KEGG:5532 ATLASONC:GC_PPP3CB WIKI:PPP3CB Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3CBtrunc*"/> <bbox w="80.0" h="40.0" x="11775.875" y="1272.0"/> <glyph class="unit of information" id="_1070391b-2e22-4464-b494-42fa60c3fa00"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="11790.875" y="1267.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s188_wnc1_wnc2_sa154"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, regulatory subunit B, alpha "protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform" HUGO:PPP3R1 HGNC:9317 ENTREZ:5534 UNIPROT:P63098 GENECARDS:PPP3R1 REACTOME:51292 KEGG:5534 ATLASONC:GC_PPP3R1 WIKI:PPP3R1 protein phosphatase 3, regulatory subunit B, beta HUGO:PPP3PR2 GENECARDS:PPP3PR2 WIKI:PPP3PR2 HUGO:PPP3R2 HGNC:9318 ENTREZ:5535 UNIPROT:Q96LZ3 GENECARDS:PPP3R2 KEGG:5535 ATLASONC:GC_PPP3R2 WIKI:PPP3R2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3R*"/> <bbox w="80.0" h="40.0" x="11775.875" y="1315.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s189_wnc1_wnc2_sa155"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="11776.875" y="1368.0"/> <glyph class="state variable" id="_43d77b2f-043e-46c0-8436-9c1143c8c26c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11851.875" y="1391.2843"/> </glyph> <glyph class="state variable" id="_5ef0d592-9372-45fb-a685-5d4d1f5be3e2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11851.875" y="1403.0"/> </glyph> <glyph class="state variable" id="_b5913b04-bef7-46ac-9b0e-5159d21a528e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11828.443" y="1403.0"/> </glyph> <glyph class="state variable" id="_84526ad8-2e2e-4a50-98f9-3c0103dd1baf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11771.875" y="1363.0"/> </glyph> <glyph class="state variable" id="_990f57b3-3446-4db8-b34f-7e01ede6e173"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11795.307" y="1363.0"/> </glyph> <glyph class="state variable" id="_0f0258e2-6345-4e76-ad8d-c5bd2502f7a4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11811.875" y="1363.0"/> </glyph> <glyph class="state variable" id="_2d5995b9-eb0d-459a-b354-0ead2baab857"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11771.875" y="1383.0"/> </glyph> <glyph class="state variable" id="_097df74f-a85c-4d77-9d55-e778cb1e39a3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11828.443" y="1363.0"/> </glyph> <glyph class="state variable" id="_792029ee-bacc-4fa5-b78d-cc02f3696e29"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11851.875" y="1363.0"/> </glyph> <glyph class="state variable" id="_449bd203-db2c-4428-879d-391b7d9fa773"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11851.875" y="1374.7157"/> </glyph> <glyph class="state variable" id="_23f032e9-3e97-4c68-ba52-41554e82d488"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11851.875" y="1383.0"/> </glyph> <glyph class="state variable" id="_4a0af1f3-e652-4e3c-b1c5-ba8d0e4cf0fb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11771.875" y="1363.0"/> </glyph> <glyph class="state variable" id="_8636ff47-9967-4244-aba8-0ca1c5aefc09"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11771.875" y="1374.7157"/> </glyph> <glyph class="state variable" id="_6807e5af-cf14-411b-b1ce-5d5bb5f5e834"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11771.875" y="1391.2843"/> </glyph> <glyph class="state variable" id="_f816b3cf-249b-4c5c-a7d5-858c3fe40943"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="11775.531" y="1403.0"/> </glyph> <glyph class="state variable" id="_bfc26103-415f-488b-89c7-7c1064f95085"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="11795.731" y="1403.0"/> </glyph> <glyph class="state variable" id="_ea548138-b7ed-48df-9055-b36f6156783a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11811.875" y="1403.0"/> </glyph> <glyph class="state variable" id="_aa9ed554-d465-4816-835e-3535eb2b4e9e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11795.307" y="1403.0"/> </glyph> <glyph class="state variable" id="_24294abc-2226-4023-8a03-653494309591"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11771.875" y="1403.0"/> </glyph> <glyph class="state variable" id="_6ae10a5a-fc0d-416e-bf5a-0efc12ffb801"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11771.875" y="1383.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s190_wnc1_wnc2_sa156"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: karyopherin (importin) beta 1 HUGO:KPNB1 HGNC:6400 ENTREZ:3837 UNIPROT:Q14974 GENECARDS:KPNB1 REACTOME:57343 KEGG:3837 ATLASONC:GC_KPNB1 WIKI:KPNB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="KPNB1"/> <bbox w="80.0" h="40.0" x="11779.625" y="1416.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s191_wnc1_wnc2_sa157"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tubulin, alpha 1a HUGO:TUBA1A HGNC:20766 ENTREZ:7846 UNIPROT:Q71U36 GENECARDS:TUBA1A REACTOME:191692 KEGG:7846 ATLASONC:GC_TUBA1A WIKI:TUBA1A SwissProt: Q71U36 tubulin, alpha 1b HUGO:TUBA1B HGNC:18809 ENTREZ:10376 UNIPROT:P68363 GENECARDS:TUBA1B REACTOME:191693 KEGG:10376 ATLASONC:GC_TUBA1B WIKI:TUBA1B SwissProt: P68363 tubulin, alpha 1c HUGO:TUBA1C HGNC:20768 ENTREZ:84790 UNIPROT:Q9BQE3 GENECARDS:TUBA1C REACTOME:65667 KEGG:84790 ATLASONC:GC_TUBA1C WIKI:TUBA1C SwissProt: Q9BQE3 tubulin, alpha 3c HUGO:TUBA3C HGNC:12408 ENTREZ:7278 UNIPROT:Q13748 GENECARDS:TUBA3C REACTOME:154750 KEGG:7278 WIKI:TUBA3C SwissProt: Q13748 tubulin, alpha 3d HUGO:TUBA3D HGNC:24071 ENTREZ:113457 UNIPROT:Q13748 GENECARDS:TUBA3D REACTOME:154750 KEGG:113457 WIKI:TUBA3D tubulin, alpha 3e HUGO:TUBA3E HGNC:20765 ENTREZ:112714 UNIPROT:Q6PEY2 GENECARDS:TUBA3E WIKI:TUBA3E SwissProt: Q6PEY2 tubulin, alpha 4a HUGO:TUBA4A HGNC:12407 ENTREZ:7277 UNIPROT:P68366 GENECARDS:TUBA4A REACTOME:191690 KEGG:7277 ATLASONC:GC_TUBA4A WIKI:TUBA4A SwissProt: P68366 tubulin, alpha 8 HUGO:TUBA8 HGNC:12410 ENTREZ:51807 UNIPROT:Q9NY65 GENECARDS:TUBA8 KEGG:51807 WIKI:TUBA8 SwissProt: Q9NY65 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Tubulin-α*"/> <bbox w="80.0" h="40.0" x="11779.625" y="1458.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s195_wnc1_wnc2_sa158"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: leucine-rich repeat kinase 2 HUGO:LRRK2 HGNC:18618 ENTREZ:120892 UNIPROT:Q5S007 GENECARDS:LRRK2 KEGG:120892 ATLASONC:GC_LRRK2 WIKI:LRRK2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LRRK2"/> <bbox w="80.0" h="40.0" x="11686.5" y="1393.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s220_wnc1_wnc2_csa32" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TAB1:TAB2:TAK1* Identifiers_end References_begin: s_wnc2_re52:(MAP:survival) PMID:19136967 s_wnc2_re73:(MAP:survival) PMID:18762249 References_end</body> </html> </notes> <label text="TAB1:TAB2:TAK1*"/> <bbox w="187.0" h="125.0" x="11477.25" y="836.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s217_wnc1_wnc2_sa172"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> </notes> <label text="TAK1*"/> <bbox w="80.0" h="40.0" x="11487.25" y="846.0"/> <glyph class="state variable" id="_66ef83b0-6eac-4deb-b2b7-a7c6b17de883"> <state value="P" variable="T187"/> <bbox w="35.0" h="10.0" x="11470.242" y="841.0"/> </glyph> <glyph class="state variable" id="_0cd20fad-f029-4f72-a6d4-bb8f03e36041"> <state value="" variable="S192"/> <bbox w="30.0" h="10.0" x="11551.632" y="881.0"/> </glyph> <glyph class="state variable" id="_b550037e-7b70-481e-9ae1-0dda89a5be02"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11482.25" y="861.0"/> </glyph> <glyph class="state variable" id="_fa26c9ae-eaa9-48e4-b921-7e8e0e2e9b11"> <state value="" variable="T184"/> <bbox w="30.0" h="10.0" x="11472.742" y="841.0"/> </glyph> <glyph class="state variable" id="_04a9bbc9-1c91-4d8a-804e-88fe295820be"> <state value="" variable="T178"/> <bbox w="30.0" h="10.0" x="11472.25" y="880.7223"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s218_wnc1_wnc2_sa173"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 1 MAP3K7IP1 "mitogen-activated protein kinase kinase kinase 7 interacting protein 1" HUGO:TAB1 HGNC:18157 ENTREZ:10454 UNIPROT:Q15750 GENECARDS:TAB1 REACTOME:65612 KEGG:10454 ATLASONC:GC_TAB1 WIKI:TAB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 1 MAP3K7IP1 "mitogen-activated protein kinase kinase kinase 7 interacting protein 1" HUGO:TAB1 HGNC:18157 ENTREZ:10454 UNIPROT:Q15750 GENECARDS:TAB1 REACTOME:65612 KEGG:10454 ATLASONC:GC_TAB1 WIKI:TAB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TAB1"/> <bbox w="80.0" h="40.0" x="11487.25" y="887.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s219_wnc1_wnc2_sa174"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 2 MAP3K7IP2 "mitogen-activated protein kinase kinase kinase 7 interacting protein 2" HUGO:TAB2 HGNC:17075 ENTREZ:23118 UNIPROT:Q9NYJ8 GENECARDS:TAB2 REACTOME:168084 KEGG:23118 ATLASONC:GC_TAB2 WIKI:TAB2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 2 MAP3K7IP2 "mitogen-activated protein kinase kinase kinase 7 interacting protein 2" HUGO:TAB2 HGNC:17075 ENTREZ:23118 UNIPROT:Q9NYJ8 GENECARDS:TAB2 REACTOME:168084 KEGG:23118 ATLASONC:GC_TAB2 WIKI:TAB2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TAB2"/> <bbox w="80.0" h="40.0" x="11571.25" y="846.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s223_wnc1_wnc2_csa33" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:RCAN*:TAB1:TAB2:TAK1* Identifiers_end References_begin: s_wnc2_re52:(MAP:survival) PMID:19136967 References_end</body> </html> </notes> <label text="RCAN*:TAB1:TAB2:TAK1*"/> <bbox w="187.0" h="125.0" x="11477.5" y="1030.5"/> <glyph class="macromolecule" id="wnc1_wnc2_s224_wnc1_wnc2_sa176"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> </notes> <label text="TAK1*"/> <bbox w="80.0" h="40.0" x="11487.5" y="1040.5"/> <glyph class="state variable" id="_9339bcf7-7bde-4ba5-a6fa-04957d934200"> <state value="P" variable="T187"/> <bbox w="35.0" h="10.0" x="11470.492" y="1035.5"/> </glyph> <glyph class="state variable" id="_b1066621-f6d4-4ce2-a2a3-33c1cd964d4c"> <state value="" variable="S192"/> <bbox w="30.0" h="10.0" x="11551.882" y="1075.5"/> </glyph> <glyph class="state variable" id="_7ff56262-8d01-4fbe-a820-4445cbfe1f63"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11482.5" y="1055.5"/> </glyph> <glyph class="state variable" id="_b9f9d0fb-1162-41ab-99ec-8ac1fa3dcc8a"> <state value="" variable="T184"/> <bbox w="30.0" h="10.0" x="11472.992" y="1035.5"/> </glyph> <glyph class="state variable" id="_c8f80af0-e6eb-4146-b5e1-8a1abad27dfe"> <state value="" variable="T178"/> <bbox w="30.0" h="10.0" x="11472.5" y="1075.2223"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s225_wnc1_wnc2_sa177"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 1 MAP3K7IP1 "mitogen-activated protein kinase kinase kinase 7 interacting protein 1" HUGO:TAB1 HGNC:18157 ENTREZ:10454 UNIPROT:Q15750 GENECARDS:TAB1 REACTOME:65612 KEGG:10454 ATLASONC:GC_TAB1 WIKI:TAB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 1 MAP3K7IP1 "mitogen-activated protein kinase kinase kinase 7 interacting protein 1" HUGO:TAB1 HGNC:18157 ENTREZ:10454 UNIPROT:Q15750 GENECARDS:TAB1 REACTOME:65612 KEGG:10454 ATLASONC:GC_TAB1 WIKI:TAB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TAB1"/> <bbox w="80.0" h="40.0" x="11487.5" y="1081.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s226_wnc1_wnc2_sa178"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 2 MAP3K7IP2 "mitogen-activated protein kinase kinase kinase 7 interacting protein 2" HUGO:TAB2 HGNC:17075 ENTREZ:23118 UNIPROT:Q9NYJ8 GENECARDS:TAB2 REACTOME:168084 KEGG:23118 ATLASONC:GC_TAB2 WIKI:TAB2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 2 MAP3K7IP2 "mitogen-activated protein kinase kinase kinase 7 interacting protein 2" HUGO:TAB2 HGNC:17075 ENTREZ:23118 UNIPROT:Q9NYJ8 GENECARDS:TAB2 REACTOME:168084 KEGG:23118 ATLASONC:GC_TAB2 WIKI:TAB2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TAB2"/> <bbox w="80.0" h="40.0" x="11571.5" y="1040.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s222_wnc1_wnc2_sa179"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: regulator of calcineurin 1 "Down syndrome critical region gene 1", DSCR1 HUGO:RCAN1 HGNC:3040 ENTREZ:1827 UNIPROT:P53805 GENECARDS:RCAN1 KEGG:1827 ATLASONC:GC_RCAN1 WIKI:RCAN1 regulator of calcineurin 2 HUGO:RCAN2 HGNC:3041 ENTREZ:10231 UNIPROT:Q14206 GENECARDS:RCAN2 KEGG:10231 ATLASONC:GC_RCAN2 WIKI:RCAN2 RCAN family member 3 "Down syndrome critical region gene 1-like 2", DSCR1L2 HUGO:RCAN3 HGNC:3042 ENTREZ:11123 UNIPROT:Q9UKA8 GENECARDS:RCAN3 KEGG:11123 ATLASONC:GC_RCAN3 WIKI:RCAN3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RCAN*"/> <bbox w="80.0" h="40.0" x="11571.5" y="1084.0"/> <glyph class="state variable" id="_9c018df0-0006-474a-b157-c44588410d54"> <state value="P" variable="S94"/> <bbox w="30.0" h="10.0" x="11556.5" y="1079.0"/> </glyph> <glyph class="state variable" id="_6be28c46-9cdf-4f4e-b608-f2a79835f4bb"> <state value="P" variable="S136"/> <bbox w="35.0" h="10.0" x="11634.0" y="1079.2147"/> </glyph> <glyph class="state variable" id="_db9c8d89-b8b9-4926-865e-eff25bdf1004"> <state value="" variable="T192"/> <bbox w="30.0" h="10.0" x="11635.882" y="1119.0"/> </glyph> <glyph class="state variable" id="_cb8847c8-e03b-4db9-ad2b-91f0a33d4102"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11623.068" y="1079.0"/> </glyph> <glyph class="state variable" id="_5dd4722a-0bea-408c-b631-f9138b9a47c2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11589.932" y="1079.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s231_wnc1_wnc2_csa35" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HOMER3:NFAT* Identifiers_end References_begin: s_wnc2_re55(MAP:survival): Homer1 binds only NFATc4/NFAT3, whereas NFATc3/NFAT4 does not bind to any Homer protein. PMID:18218901 References_end</body> </html> </notes> <label text="HOMER3:NFAT*"/> <bbox w="108.0" h="138.0" x="10213.0" y="1733.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s233_wnc1_wnc2_sa185"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: homer homolog 3 (Drosophila) HUGO:HOMER3 HGNC:17514 ENTREZ:9454 UNIPROT:Q9NSC5 GENECARDS:HOMER3 KEGG:9454 WIKI:HOMER3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HOMER3"/> <bbox w="80.0" h="40.0" x="10225.75" y="1752.0"/> <glyph class="state variable" id="_28ce5463-fedd-4716-81ff-4a2cec7c4ed9"> <state value="" variable="T36"/> <bbox w="25.0" h="10.0" x="10213.742" y="1747.0"/> </glyph> <glyph class="state variable" id="_cc36f167-4509-4979-8be4-0b83b2d85b79"> <state value="" variable="S38"/> <bbox w="25.0" h="10.0" x="10253.282" y="1747.0"/> </glyph> <glyph class="state variable" id="_42bab6e1-c6ac-4d5a-90ac-3d79e7beac52"> <state value="" variable="S52"/> <bbox w="25.0" h="10.0" x="10293.25" y="1747.2147"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s232_wnc1_wnc2_sa186"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="10225.75" y="1800.0"/> <glyph class="state variable" id="_21c6c495-3ff8-4af4-9286-85dfcf562024"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10298.25" y="1823.2843"/> </glyph> <glyph class="state variable" id="_15e46217-17c6-4227-8aff-41b0647c28d5"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10298.25" y="1835.0"/> </glyph> <glyph class="state variable" id="_11e35aab-3ece-4c74-9d2a-ec1c82653d8f"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10274.818" y="1835.0"/> </glyph> <glyph class="state variable" id="_e01ec1ee-d049-4c1c-bf8e-65e076e10bd4"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10218.25" y="1795.0"/> </glyph> <glyph class="state variable" id="_2372d53a-8d4f-4f5c-ba74-e563f3279ffa"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10241.682" y="1795.0"/> </glyph> <glyph class="state variable" id="_718df57a-57ce-46c3-81a8-d37fe8904402"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10258.25" y="1795.0"/> </glyph> <glyph class="state variable" id="_eff38c2a-3bcc-4e75-95e6-e23555f48c76"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10220.75" y="1815.0"/> </glyph> <glyph class="state variable" id="_7ef58c42-c7b5-4e78-8ea3-e276d243edc5"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10274.818" y="1795.0"/> </glyph> <glyph class="state variable" id="_4a829f21-5247-4164-bc50-66f17c8cb13c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10298.25" y="1795.0"/> </glyph> <glyph class="state variable" id="_ce0ecd0a-c68e-4b33-81fc-a26e69084b8d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10298.25" y="1806.7157"/> </glyph> <glyph class="state variable" id="_2a2d19bb-2ae9-4fbf-aa20-127ac688be84"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10298.25" y="1815.0"/> </glyph> <glyph class="state variable" id="_26a21037-e4e8-4a0f-941e-57dbe626659e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10220.75" y="1795.0"/> </glyph> <glyph class="state variable" id="_6aec2a85-f8db-45c3-b8d7-56d5a849e331"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10220.75" y="1806.7157"/> </glyph> <glyph class="state variable" id="_12a15c44-f3af-4224-b9ba-cd4b128f8e20"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10220.75" y="1823.2843"/> </glyph> <glyph class="state variable" id="_459c92b5-1e52-4f47-ae98-4940ae5dbc97"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="10224.406" y="1835.0"/> </glyph> <glyph class="state variable" id="_0bfe0412-d550-418a-bab5-1de6e87b16e4"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="10244.606" y="1835.0"/> </glyph> <glyph class="state variable" id="_60526167-94d4-4543-9510-6c4363c33ac5"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10258.25" y="1835.0"/> </glyph> <glyph class="state variable" id="_51c2a95e-bccd-41cd-8bdb-9b30d963f5d6"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10241.682" y="1835.0"/> </glyph> <glyph class="state variable" id="_cc793d0b-0022-46bc-a445-f166fb2ee5c6"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10218.25" y="1835.0"/> </glyph> <glyph class="state variable" id="_917b0ffa-a3bc-44f8-968e-10fffdbc4f8c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10218.25" y="1815.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s268_wnc1_wnc2_csa38" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ATROGIN-1*:CUL1:RBX1:SKP1 Identifiers_end References_begin: s_wnc2_re68:(MAP:survival) PMID:15489953 References_end</body> </html> </notes> <label text="ATROGIN-1*:CUL1:RBX1:SKP1"/> <bbox w="180.0" h="134.0" x="9904.0" y="1990.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s264_wnc1_wnc2_sa210"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 "S-phase kinase-associated protein 1A (p19A)", SKP1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 "S-phase kinase-associated protein 1A (p19A)", SKP1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 "S-phase kinase-associated protein 1A (p19A)", SKP1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> </notes> <label text="SKP1"/> <bbox w="80.0" h="40.0" x="9913.0" y="2001.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s265_wnc1_wnc2_sa211"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> </notes> <label text="CUL1"/> <bbox w="80.0" h="40.0" x="9913.0" y="2045.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s266_wnc1_wnc2_sa212"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> </notes> <label text="RBX1"/> <bbox w="80.0" h="40.0" x="9997.0" y="2001.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s267_wnc1_wnc2_sa213"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: F-box protein 32 HUGO:FBXO32 HGNC:16731 ENTREZ:114907 UNIPROT:Q969P5 GENECARDS:FBXO32 KEGG:114907 ATLASONC:GC_FBXO32 WIKI:FBXO32 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ATROGIN-1*"/> <bbox w="80.0" h="40.0" x="9997.0" y="2045.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s281_wnc1_wnc2_csa34" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TAB1:TAB2:TAK1* Identifiers_end References_begin: s_wnc2_re53:(MAP:survival) PMID:19136967 References_end</body> </html> </notes> <label text="TAB1:TAB2:TAK1*"/> <bbox w="187.0" h="125.0" x="11238.625" y="836.5"/> <glyph class="macromolecule" id="wnc1_wnc2_s284_wnc1_wnc2_sa180"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> </notes> <label text="TAK1*"/> <bbox w="80.0" h="40.0" x="11248.625" y="846.5"/> <glyph class="state variable" id="_11191fc9-1d03-4419-b4b1-bd8117657fd6"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="11234.117" y="841.5"/> </glyph> <glyph class="state variable" id="_b6397aa5-296b-4eff-84aa-06c8ad7d46c5"> <state value="" variable="S192"/> <bbox w="30.0" h="10.0" x="11313.007" y="881.5"/> </glyph> <glyph class="state variable" id="_a7446b6f-dddf-45c1-a868-7ad219ba3d0b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11243.625" y="861.5"/> </glyph> <glyph class="state variable" id="_12189159-240e-4cd4-80cc-f3d316415170"> <state value="" variable="T184"/> <bbox w="30.0" h="10.0" x="11234.117" y="841.5"/> </glyph> <glyph class="state variable" id="_4bceafda-cf02-4738-be91-79a374e08b83"> <state value="" variable="T178"/> <bbox w="30.0" h="10.0" x="11233.625" y="881.2223"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s282_wnc1_wnc2_sa181"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 1 MAP3K7IP1 "mitogen-activated protein kinase kinase kinase 7 interacting protein 1" HUGO:TAB1 HGNC:18157 ENTREZ:10454 UNIPROT:Q15750 GENECARDS:TAB1 REACTOME:65612 KEGG:10454 ATLASONC:GC_TAB1 WIKI:TAB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 1 MAP3K7IP1 "mitogen-activated protein kinase kinase kinase 7 interacting protein 1" HUGO:TAB1 HGNC:18157 ENTREZ:10454 UNIPROT:Q15750 GENECARDS:TAB1 REACTOME:65612 KEGG:10454 ATLASONC:GC_TAB1 WIKI:TAB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TAB1"/> <bbox w="80.0" h="40.0" x="11248.625" y="887.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s283_wnc1_wnc2_sa182"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 2 MAP3K7IP2 "mitogen-activated protein kinase kinase kinase 7 interacting protein 2" HUGO:TAB2 HGNC:17075 ENTREZ:23118 UNIPROT:Q9NYJ8 GENECARDS:TAB2 REACTOME:168084 KEGG:23118 ATLASONC:GC_TAB2 WIKI:TAB2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 2 MAP3K7IP2 "mitogen-activated protein kinase kinase kinase 7 interacting protein 2" HUGO:TAB2 HGNC:17075 ENTREZ:23118 UNIPROT:Q9NYJ8 GENECARDS:TAB2 REACTOME:168084 KEGG:23118 ATLASONC:GC_TAB2 WIKI:TAB2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TAB2"/> <bbox w="80.0" h="40.0" x="11332.625" y="846.5"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s293_wnc1_wnc2_csa40" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ROR2:TAB1:TAB2:TAK1* Identifiers_end References_begin: s_wnc2_re74:(MAP:survival) PMID:18762249 References_end</body> </html> </notes> <label text="ROR2/TAK1/TAB1/TAB2"/> <bbox w="287.0" h="145.0" x="9775.125" y="2476.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s289_wnc1_wnc2_sa225"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> </notes> <label text="TAK1*"/> <bbox w="80.0" h="40.0" x="9885.125" y="2504.0"/> <glyph class="state variable" id="_38292017-f434-4e76-9367-898bdf04422e"> <state value="P" variable="T187"/> <bbox w="35.0" h="10.0" x="9868.117" y="2499.0"/> </glyph> <glyph class="state variable" id="_806ccca2-2186-4b07-b343-5cc1cd8dc7dd"> <state value="" variable="S192"/> <bbox w="30.0" h="10.0" x="9949.507" y="2539.0"/> </glyph> <glyph class="state variable" id="_6bcc22c9-565c-4932-891d-3f557eba1e86"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9880.125" y="2519.0"/> </glyph> <glyph class="state variable" id="_b990d13e-e687-4864-962c-32e3352415a2"> <state value="" variable="T184"/> <bbox w="30.0" h="10.0" x="9870.617" y="2499.0"/> </glyph> <glyph class="state variable" id="_eb20456c-e6b7-4efc-8eeb-644f062b1bf0"> <state value="" variable="T178"/> <bbox w="30.0" h="10.0" x="9870.125" y="2538.7224"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s290_wnc1_wnc2_sa226"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 1 MAP3K7IP1 "mitogen-activated protein kinase kinase kinase 7 interacting protein 1" HUGO:TAB1 HGNC:18157 ENTREZ:10454 UNIPROT:Q15750 GENECARDS:TAB1 REACTOME:65612 KEGG:10454 ATLASONC:GC_TAB1 WIKI:TAB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 1 MAP3K7IP1 "mitogen-activated protein kinase kinase kinase 7 interacting protein 1" HUGO:TAB1 HGNC:18157 ENTREZ:10454 UNIPROT:Q15750 GENECARDS:TAB1 REACTOME:65612 KEGG:10454 ATLASONC:GC_TAB1 WIKI:TAB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TAB1"/> <bbox w="80.0" h="40.0" x="9885.125" y="2545.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s291_wnc1_wnc2_sa227"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 2 MAP3K7IP2 "mitogen-activated protein kinase kinase kinase 7 interacting protein 2" HUGO:TAB2 HGNC:17075 ENTREZ:23118 UNIPROT:Q9NYJ8 GENECARDS:TAB2 REACTOME:168084 KEGG:23118 ATLASONC:GC_TAB2 WIKI:TAB2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 2 MAP3K7IP2 "mitogen-activated protein kinase kinase kinase 7 interacting protein 2" HUGO:TAB2 HGNC:17075 ENTREZ:23118 UNIPROT:Q9NYJ8 GENECARDS:TAB2 REACTOME:168084 KEGG:23118 ATLASONC:GC_TAB2 WIKI:TAB2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TAB2"/> <bbox w="80.0" h="40.0" x="9969.125" y="2504.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s292_wnc1_wnc2_sa228"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ROR2"/> <bbox w="80.0" h="50.0" x="9790.0" y="2549.5"/> <glyph class="state variable" id="_c04fd433-73a2-4c89-ac9a-7791e91099ea"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9825.0" y="2594.5"/> </glyph> <glyph class="state variable" id="_c930e642-1975-4098-996d-047a5338d75d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9782.5" y="2544.5"/> </glyph> <glyph class="state variable" id="_66998b5d-e115-40b6-90a8-34f3d2bfa27b"> <state value="" variable="S864"/> <bbox w="30.0" h="10.0" x="9855.0" y="2544.7686"/> </glyph> <glyph class="state variable" id="_32cb7463-5659-4843-9e8d-1df0c1dfcbee"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9865.0" y="2594.5"/> </glyph> <glyph class="unit of information" id="_b8966ae3-1f4e-4bc8-83cb-082cfd97bec9"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9807.5" y="2544.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s1093_wnc1_sa1009"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="9789.0" y="2506.0"/> <glyph class="unit of information" id="_cd06420b-fe98-4a72-8bb3-5d7a5037562b"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9806.5" y="2501.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s1094_wnc1_sa1010"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: wingless-type MMTV integration site family, member 3 INT4 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="WNT3"/> <bbox w="40.0" h="22.0" x="9809.0" y="2486.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s302_wnc1_wnc2_csa41" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FZD*:ROR2:WNT3 Identifiers_end References_begin: s_wnc2_re73:(MAP:survival) PMID:18762249 References_end</body> </html> </notes> <label text="FZD*:ROR2:WNT3"/> <bbox w="98.0" h="139.0" x="9782.0" y="2052.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s304_wnc1_wnc2_sa222"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ROR2"/> <bbox w="80.0" h="50.0" x="9792.0" y="2071.0"/> <glyph class="state variable" id="_a3726344-0f64-46de-887a-f15b6a48e02a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9827.0" y="2116.0"/> </glyph> <glyph class="state variable" id="_383eecc9-cf71-464f-9874-b203c83fca02"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9787.0" y="2066.0"/> </glyph> <glyph class="state variable" id="_3676ebe7-2d38-4446-9b11-2c214a7d3221"> <state value="" variable="S864"/> <bbox w="30.0" h="10.0" x="9857.0" y="2066.2686"/> </glyph> <glyph class="state variable" id="_c9cc6e4f-07ca-4864-a432-c4b31d0793ad"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9867.0" y="2116.0"/> </glyph> <glyph class="unit of information" id="_f780e014-2b7a-4aff-8f49-62f18b3d1787"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9809.5" y="2066.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s305_wnc1_wnc2_sa232"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: wingless-type MMTV integration site family, member 3 INT4 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="WNT3"/> <bbox w="40.0" h="22.0" x="9812.0" y="2060.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s306_wnc1_wnc2_sa234"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="9792.0" y="2113.5"/> <glyph class="unit of information" id="_3ccc12d2-72db-412b-af3c-2bac3caecf79"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9809.5" y="2108.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s303_wnc1_wnc2_csa42" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FZD*:ROR2:WNT3 Identifiers_end References_begin: s_wnc2_re73:(MAP:survival) PMID:18762249 References_end</body> </html> </notes> <label text="FZD*:ROR2:WNT3"/> <bbox w="98.0" h="139.0" x="9782.0" y="2245.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s286_wnc1_wnc2_sa224"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ROR2"/> <bbox w="80.0" h="50.0" x="9791.0" y="2264.5"/> <glyph class="state variable" id="_8296d6bd-7da1-4202-ba16-797061a48e87"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9826.0" y="2309.5"/> </glyph> <glyph class="state variable" id="_6d947361-5cd8-4185-a2a2-3c4e4fd3f841"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="9783.5" y="2259.5"/> </glyph> <glyph class="state variable" id="_de1d95fd-bd83-4a28-8b3a-0f47003bf66f"> <state value="" variable="S864"/> <bbox w="30.0" h="10.0" x="9856.0" y="2259.7686"/> </glyph> <glyph class="state variable" id="_b744c47b-97b6-43b1-a332-fe6c4afd0c8a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9866.0" y="2309.5"/> </glyph> <glyph class="unit of information" id="_eda94b8f-7b42-45cf-8db9-80ee014af6f5"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9808.5" y="2259.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s297_wnc1_wnc2_sa236"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: wingless-type MMTV integration site family, member 3 INT4 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="WNT3"/> <bbox w="40.0" h="22.0" x="9812.0" y="2253.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s301_wnc1_wnc2_sa237"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="9792.0" y="2306.5"/> <glyph class="unit of information" id="_585abae0-8239-4d4e-a1a2-b3347ebab1b4"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9809.5" y="2301.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s319_wnc1_wnc2_csa43" compartmentRef="wnc1_wnc2_c4_wnc1_wnc2_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:NFAT* Identifiers_end References_begin: s_wnc2_re86:(MAP:survival) PMID:10611249 References_end</body> </html> </notes> <label text="14-3-3*:NFAT*"/> <bbox w="107.0" h="135.0" x="10769.0" y="2061.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s323_wnc1_wnc2_sa245"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="10783.75" y="2069.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s324_wnc1_wnc2_sa246"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="10784.25" y="2119.0"/> <glyph class="state variable" id="_0bfd6174-2cf6-4a81-b741-fb1452619009"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10859.25" y="2142.2842"/> </glyph> <glyph class="state variable" id="_b1a5301c-b79f-41eb-b784-231e4fc8f467"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10859.25" y="2154.0"/> </glyph> <glyph class="state variable" id="_334121be-8b5f-48d6-955d-dd8d463b8ade"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10835.818" y="2154.0"/> </glyph> <glyph class="state variable" id="_c69ab620-1c96-4ea6-a181-e1b6f104d768"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10779.25" y="2114.0"/> </glyph> <glyph class="state variable" id="_dc09785b-707c-4659-883b-73eb7ebe5975"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10802.682" y="2114.0"/> </glyph> <glyph class="state variable" id="_06a80be6-f191-4502-9ebe-8421e17a0dd6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10819.25" y="2114.0"/> </glyph> <glyph class="state variable" id="_065cbcf8-d229-4ad0-8da5-f5f811efeb92"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10779.25" y="2134.0"/> </glyph> <glyph class="state variable" id="_9e6500e4-2d5d-42c1-ab37-cd132df52031"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10835.818" y="2114.0"/> </glyph> <glyph class="state variable" id="_9d09f72b-ae2f-489d-8686-a6d442c91841"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10859.25" y="2114.0"/> </glyph> <glyph class="state variable" id="_6775abfc-cae2-4f59-a6c0-c1a9f3dc0773"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10859.25" y="2125.7158"/> </glyph> <glyph class="state variable" id="_96e47750-4879-4835-ad4f-5c71fbd81f85"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10859.25" y="2134.0"/> </glyph> <glyph class="state variable" id="_c213aa2a-1785-406c-bf2d-ab4197a1cede"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10779.25" y="2114.0"/> </glyph> <glyph class="state variable" id="_4229ba7d-3443-4f0e-8237-2122cc541d52"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10779.25" y="2125.7158"/> </glyph> <glyph class="state variable" id="_8824553c-ac27-4cc4-82c8-4d1a735c1953"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10779.25" y="2142.2842"/> </glyph> <glyph class="state variable" id="_abad2ab3-b871-4ac1-a31b-e61206d7016a"> <state value="P" variable="S289"/> <bbox w="35.0" h="10.0" x="10780.406" y="2154.0"/> </glyph> <glyph class="state variable" id="_35d79bcb-e479-4f41-8198-e99b780c74a9"> <state value="P" variable="S272"/> <bbox w="35.0" h="10.0" x="10800.606" y="2154.0"/> </glyph> <glyph class="state variable" id="_53629d10-cc53-4d1a-b1eb-a6c488412b0e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10819.25" y="2154.0"/> </glyph> <glyph class="state variable" id="_48f11ad1-d577-419c-a962-9aae38be816f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10802.682" y="2154.0"/> </glyph> <glyph class="state variable" id="_92cf1ec7-1cfa-4d5e-b1e7-4a9620b3d2b2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10779.25" y="2154.0"/> </glyph> <glyph class="state variable" id="_51c0669b-0669-4454-8d2d-7993d160b82e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10779.25" y="2134.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s322_wnc1_wnc2_csa44" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:NFAT* Identifiers_end References_begin: s_wnc2_re87:(MAP:survival) PMID:10611249 References_end</body> </html> </notes> <label text="14-3-3*:NFAT*"/> <bbox w="107.0" h="135.0" x="10539.0" y="2061.5"/> <glyph class="macromolecule" id="wnc1_wnc2_s321_wnc1_wnc2_sa247"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="10553.75" y="2069.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s320_wnc1_wnc2_sa248"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="10554.25" y="2119.5"/> <glyph class="state variable" id="_adc37e45-2405-4a33-86cc-3b81990110c4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10629.25" y="2142.7842"/> </glyph> <glyph class="state variable" id="_9069cfc4-d7d5-460c-b496-b9a89a0a7071"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10629.25" y="2154.5"/> </glyph> <glyph class="state variable" id="_ecc133d3-34af-4a78-9d54-6c38ce8f590c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10605.818" y="2154.5"/> </glyph> <glyph class="state variable" id="_e92f463c-a247-4996-8350-779c0792da50"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10549.25" y="2114.5"/> </glyph> <glyph class="state variable" id="_be8926c1-ae7a-40fc-9653-dc8dff0464db"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10572.682" y="2114.5"/> </glyph> <glyph class="state variable" id="_0e4b0acf-0c29-45e1-aa1a-d1ced9cc7acb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10589.25" y="2114.5"/> </glyph> <glyph class="state variable" id="_4f577eea-407f-49e0-af06-e0075dfe3bb7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10549.25" y="2134.5"/> </glyph> <glyph class="state variable" id="_b4009aa7-59f4-4ef5-a250-98b51249e7ed"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10605.818" y="2114.5"/> </glyph> <glyph class="state variable" id="_b6716d8e-0a1c-492f-81c8-1be60d7b30b8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10629.25" y="2114.5"/> </glyph> <glyph class="state variable" id="_917b6cde-28b0-499d-82c3-1b55ab50a505"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10629.25" y="2126.2158"/> </glyph> <glyph class="state variable" id="_6935f304-1236-4b76-ad78-2de4e2f2a590"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10629.25" y="2134.5"/> </glyph> <glyph class="state variable" id="_ddac0777-9998-47cb-8d74-9fe07674e279"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10549.25" y="2114.5"/> </glyph> <glyph class="state variable" id="_681c502c-4015-4888-a3a5-e12a2fcf5a31"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10549.25" y="2126.2158"/> </glyph> <glyph class="state variable" id="_f6ab9641-70d7-44e1-ba6c-09d4a3973340"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10549.25" y="2142.7842"/> </glyph> <glyph class="state variable" id="_7756caf4-2acd-4d6f-9a1f-5668838fbd34"> <state value="P" variable="S289"/> <bbox w="35.0" h="10.0" x="10550.406" y="2154.5"/> </glyph> <glyph class="state variable" id="_bcc32dce-7fb5-4876-8c4b-e077494cddca"> <state value="P" variable="S272"/> <bbox w="35.0" h="10.0" x="10570.606" y="2154.5"/> </glyph> <glyph class="state variable" id="_6eef38bc-7b7d-4aaa-8916-5fcfcec3ba26"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10589.25" y="2154.5"/> </glyph> <glyph class="state variable" id="_9ad3ee3e-e664-47fa-91d8-dd9d608f0247"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10572.682" y="2154.5"/> </glyph> <glyph class="state variable" id="_d7793f80-c27a-48eb-b393-71fdfc77d377"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10549.25" y="2154.5"/> </glyph> <glyph class="state variable" id="_ec968b69-51ba-40a6-94b4-12ab9f97ad16"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10549.25" y="2134.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s327_wnc1_wnc2_csa46" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PKA_C*:PKA_R* Identifiers_end References_begin: s_wnc2_re4(MAP:survival): PMID:21506126, PMID:21303971 Path to phosphorylation of b-catenin is not completely depicted here. For full paths see AKT-pathway Activated CaSR inhibits phosphorylation of b-catenin, exact mechanism unknown PMID:22094462 References_end</body> </html> </notes> <label text="(PKA)"/> <bbox w="110.0" h="92.0" x="11360.0" y="570.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s328_wnc1_wnc2_sa250"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: protein kinase AMP-activated beta 1 non-catalytic subunit HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478 GENECARDS:PRKAB1 REACTOME:49384 KEGG:5564 ATLASONC:PRKAB1ID44100ch12q24 WIKI:PRKAB1 protein kinase AMP-activated beta 2 non-catalytic subunit HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741 GENECARDS:PRKAB2 REACTOME:49386 ATLASONC:GC_PRKAB2 WIKI:PRKAB2 protein kinase AMP-activated gamma 1 non-catalytic subunit HUGO:PRKAG1 HGNC:9385 ENTREZ:5571 UNIPROT:P54619 GENECARDS:PRKAG1 REACTOME:49388 KEGG:5571 ATLASONC:GC_PRKAG1 WIKI:PRKAG1 protein kinase AMP-activated gamma 2 non-catalytic subunit HUGO:PRKAG2 HGNC:9386 ENTREZ:51422 UNIPROT:Q9UGJ0 GENECARDS:PRKAG2 REACTOME:49390 KEGG:51422 ATLASONC:GC_PRKAG2 WIKI:PRKAG2 HUGO:PRKAG3 HGNC:9387 ENTREZ:53632 UNIPROT:Q9UGI9 GENECARDS:PRKAG3 REACTOME:49392 KEGG:53632 ATLASONC:GC_PRKAG3 WIKI:PRKAG3 protein kinase cAMP-dependent regulatory type I alpha HUGO:PRKAR1A HGNC:9388 ENTREZ:5573 UNIPROT:P10644 GENECARDS:PRKAR1A REACTOME:57837 KEGG:5573 ATLASONC:PRKAR1AID387 WIKI:PRKAR1A protein kinase cAMP-dependent regulatory type I beta HUGO:PRKAR1B HGNC:9390 ENTREZ:5575 UNIPROT:P31321 GENECARDS:PRKAR1B REACTOME:57839 KEGG:5575 ATLASONC:GC_PRKAR1B WIKI:PRKAR1B protein kinase cAMP-dependent regulatory type II alpha HUGO:PRKAR2A HGNC:9391 ENTREZ:5576 UNIPROT:P13861 GENECARDS:PRKAR2A REACTOME:57841 KEGG:5576 ATLASONC:GC_PRKAR2A WIKI:PRKAR2A protein kinase cAMP-dependent regulatory type II beta HUGO:PRKAR2B HGNC:9392 ENTREZ:5577 UNIPROT:P31323 GENECARDS:PRKAR2B REACTOME:57843 KEGG:5577 ATLASONC:GC_PRKAR2B WIKI:PRKAR2B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: protein kinase AMP-activated beta 1 non-catalytic subunit HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478 GENECARDS:PRKAB1 REACTOME:49384 KEGG:5564 ATLASONC:PRKAB1ID44100ch12q24 WIKI:PRKAB1 protein kinase AMP-activated beta 2 non-catalytic subunit HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741 GENECARDS:PRKAB2 REACTOME:49386 ATLASONC:GC_PRKAB2 WIKI:PRKAB2 protein kinase AMP-activated gamma 1 non-catalytic subunit HUGO:PRKAG1 HGNC:9385 ENTREZ:5571 UNIPROT:P54619 GENECARDS:PRKAG1 REACTOME:49388 KEGG:5571 ATLASONC:GC_PRKAG1 WIKI:PRKAG1 protein kinase AMP-activated gamma 2 non-catalytic subunit HUGO:PRKAG2 HGNC:9386 ENTREZ:51422 UNIPROT:Q9UGJ0 GENECARDS:PRKAG2 REACTOME:49390 KEGG:51422 ATLASONC:GC_PRKAG2 WIKI:PRKAG2 HUGO:PRKAG3 HGNC:9387 ENTREZ:53632 UNIPROT:Q9UGI9 GENECARDS:PRKAG3 REACTOME:49392 KEGG:53632 ATLASONC:GC_PRKAG3 WIKI:PRKAG3 protein kinase cAMP-dependent regulatory type I alpha HUGO:PRKAR1A HGNC:9388 ENTREZ:5573 UNIPROT:P10644 GENECARDS:PRKAR1A REACTOME:57837 KEGG:5573 ATLASONC:PRKAR1AID387 WIKI:PRKAR1A protein kinase cAMP-dependent regulatory type I beta HUGO:PRKAR1B HGNC:9390 ENTREZ:5575 UNIPROT:P31321 GENECARDS:PRKAR1B REACTOME:57839 KEGG:5575 ATLASONC:GC_PRKAR1B WIKI:PRKAR1B protein kinase cAMP-dependent regulatory type II alpha HUGO:PRKAR2A HGNC:9391 ENTREZ:5576 UNIPROT:P13861 GENECARDS:PRKAR2A REACTOME:57841 KEGG:5576 ATLASONC:GC_PRKAR2A WIKI:PRKAR2A protein kinase cAMP-dependent regulatory type II beta HUGO:PRKAR2B HGNC:9392 ENTREZ:5577 UNIPROT:P31323 GENECARDS:PRKAR2B REACTOME:57843 KEGG:5577 ATLASONC:GC_PRKAR2B WIKI:PRKAR2B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PKA_R*"/> <bbox w="45.0" h="25.0" x="11367.0" y="581.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s328_wnc1_wnc2_sa255"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: protein kinase AMP-activated beta 1 non-catalytic subunit HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478 GENECARDS:PRKAB1 REACTOME:49384 KEGG:5564 ATLASONC:PRKAB1ID44100ch12q24 WIKI:PRKAB1 protein kinase AMP-activated beta 2 non-catalytic subunit HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741 GENECARDS:PRKAB2 REACTOME:49386 ATLASONC:GC_PRKAB2 WIKI:PRKAB2 protein kinase AMP-activated gamma 1 non-catalytic subunit HUGO:PRKAG1 HGNC:9385 ENTREZ:5571 UNIPROT:P54619 GENECARDS:PRKAG1 REACTOME:49388 KEGG:5571 ATLASONC:GC_PRKAG1 WIKI:PRKAG1 protein kinase AMP-activated gamma 2 non-catalytic subunit HUGO:PRKAG2 HGNC:9386 ENTREZ:51422 UNIPROT:Q9UGJ0 GENECARDS:PRKAG2 REACTOME:49390 KEGG:51422 ATLASONC:GC_PRKAG2 WIKI:PRKAG2 HUGO:PRKAG3 HGNC:9387 ENTREZ:53632 UNIPROT:Q9UGI9 GENECARDS:PRKAG3 REACTOME:49392 KEGG:53632 ATLASONC:GC_PRKAG3 WIKI:PRKAG3 protein kinase cAMP-dependent regulatory type I alpha HUGO:PRKAR1A HGNC:9388 ENTREZ:5573 UNIPROT:P10644 GENECARDS:PRKAR1A REACTOME:57837 KEGG:5573 ATLASONC:PRKAR1AID387 WIKI:PRKAR1A protein kinase cAMP-dependent regulatory type I beta HUGO:PRKAR1B HGNC:9390 ENTREZ:5575 UNIPROT:P31321 GENECARDS:PRKAR1B REACTOME:57839 KEGG:5575 ATLASONC:GC_PRKAR1B WIKI:PRKAR1B protein kinase cAMP-dependent regulatory type II alpha HUGO:PRKAR2A HGNC:9391 ENTREZ:5576 UNIPROT:P13861 GENECARDS:PRKAR2A REACTOME:57841 KEGG:5576 ATLASONC:GC_PRKAR2A WIKI:PRKAR2A protein kinase cAMP-dependent regulatory type II beta HUGO:PRKAR2B HGNC:9392 ENTREZ:5577 UNIPROT:P31323 GENECARDS:PRKAR2B REACTOME:57843 KEGG:5577 ATLASONC:GC_PRKAR2B WIKI:PRKAR2B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: protein kinase AMP-activated beta 1 non-catalytic subunit HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478 GENECARDS:PRKAB1 REACTOME:49384 KEGG:5564 ATLASONC:PRKAB1ID44100ch12q24 WIKI:PRKAB1 protein kinase AMP-activated beta 2 non-catalytic subunit HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741 GENECARDS:PRKAB2 REACTOME:49386 ATLASONC:GC_PRKAB2 WIKI:PRKAB2 protein kinase AMP-activated gamma 1 non-catalytic subunit HUGO:PRKAG1 HGNC:9385 ENTREZ:5571 UNIPROT:P54619 GENECARDS:PRKAG1 REACTOME:49388 KEGG:5571 ATLASONC:GC_PRKAG1 WIKI:PRKAG1 protein kinase AMP-activated gamma 2 non-catalytic subunit HUGO:PRKAG2 HGNC:9386 ENTREZ:51422 UNIPROT:Q9UGJ0 GENECARDS:PRKAG2 REACTOME:49390 KEGG:51422 ATLASONC:GC_PRKAG2 WIKI:PRKAG2 HUGO:PRKAG3 HGNC:9387 ENTREZ:53632 UNIPROT:Q9UGI9 GENECARDS:PRKAG3 REACTOME:49392 KEGG:53632 ATLASONC:GC_PRKAG3 WIKI:PRKAG3 protein kinase cAMP-dependent regulatory type I alpha HUGO:PRKAR1A HGNC:9388 ENTREZ:5573 UNIPROT:P10644 GENECARDS:PRKAR1A REACTOME:57837 KEGG:5573 ATLASONC:PRKAR1AID387 WIKI:PRKAR1A protein kinase cAMP-dependent regulatory type I beta HUGO:PRKAR1B HGNC:9390 ENTREZ:5575 UNIPROT:P31321 GENECARDS:PRKAR1B REACTOME:57839 KEGG:5575 ATLASONC:GC_PRKAR1B WIKI:PRKAR1B protein kinase cAMP-dependent regulatory type II alpha HUGO:PRKAR2A HGNC:9391 ENTREZ:5576 UNIPROT:P13861 GENECARDS:PRKAR2A REACTOME:57841 KEGG:5576 ATLASONC:GC_PRKAR2A WIKI:PRKAR2A protein kinase cAMP-dependent regulatory type II beta HUGO:PRKAR2B HGNC:9392 ENTREZ:5577 UNIPROT:P31323 GENECARDS:PRKAR2B REACTOME:57843 KEGG:5577 ATLASONC:GC_PRKAR2B WIKI:PRKAR2B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PKA_R*"/> <bbox w="45.0" h="25.0" x="11414.0" y="581.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s329_wnc1_wnc2_sa256"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: HUGO:PRKAA1 HGNC:9376 ENTREZ:5562 UNIPROT:Q13131 GENECARDS:PRKAA1 REACTOME:49380 KEGG:5562 ATLASONC:GC_PRKAA1 WIKI:PRKAA1 HUGO:PRKAA2 HGNC:9377 ENTREZ:5563 UNIPROT:P54646 GENECARDS:PRKAA2 REACTOME:49382 KEGG:5563 ATLASONC:GC_PRKAA2 WIKI:PRKAA2 HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 GENECARDS:PRKACG REACTOME:57849 KEGG:5568 ATLASONC:GC_PRKACG WIKI:PRKACG Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: HUGO:PRKAA1 HGNC:9376 ENTREZ:5562 UNIPROT:Q13131 GENECARDS:PRKAA1 REACTOME:49380 KEGG:5562 ATLASONC:GC_PRKAA1 WIKI:PRKAA1 HUGO:PRKAA2 HGNC:9377 ENTREZ:5563 UNIPROT:P54646 GENECARDS:PRKAA2 REACTOME:49382 KEGG:5563 ATLASONC:GC_PRKAA2 WIKI:PRKAA2 HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 GENECARDS:PRKACG REACTOME:57849 KEGG:5568 ATLASONC:GC_PRKACG WIKI:PRKACG Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PKA_C*"/> <bbox w="45.0" h="25.0" x="11369.0" y="610.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s329_wnc1_wnc2_sa257"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: HUGO:PRKAA1 HGNC:9376 ENTREZ:5562 UNIPROT:Q13131 GENECARDS:PRKAA1 REACTOME:49380 KEGG:5562 ATLASONC:GC_PRKAA1 WIKI:PRKAA1 HUGO:PRKAA2 HGNC:9377 ENTREZ:5563 UNIPROT:P54646 GENECARDS:PRKAA2 REACTOME:49382 KEGG:5563 ATLASONC:GC_PRKAA2 WIKI:PRKAA2 HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 GENECARDS:PRKACG REACTOME:57849 KEGG:5568 ATLASONC:GC_PRKACG WIKI:PRKACG Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: HUGO:PRKAA1 HGNC:9376 ENTREZ:5562 UNIPROT:Q13131 GENECARDS:PRKAA1 REACTOME:49380 KEGG:5562 ATLASONC:GC_PRKAA1 WIKI:PRKAA1 HUGO:PRKAA2 HGNC:9377 ENTREZ:5563 UNIPROT:P54646 GENECARDS:PRKAA2 REACTOME:49382 KEGG:5563 ATLASONC:GC_PRKAA2 WIKI:PRKAA2 HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 GENECARDS:PRKACG REACTOME:57849 KEGG:5568 ATLASONC:GC_PRKACG WIKI:PRKACG Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PKA_C*"/> <bbox w="45.0" h="25.0" x="11417.0" y="610.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s330_wnc1_wnc2_csa47" compartmentRef="wnc1_wnc2_c4_wnc1_wnc2_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PKA_C*:PKA_R* Identifiers_end References_begin: s_wnc2_re85(MAP:survival): S272 and S89 are PKA sites in NFAT3 PMID:10611249 References_end</body> </html> </notes> <label text="(PKA)"/> <bbox w="110.0" h="92.0" x="11538.0" y="1929.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s331_wnc1_wnc2_sa258"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: protein kinase AMP-activated beta 1 non-catalytic subunit HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478 GENECARDS:PRKAB1 REACTOME:49384 KEGG:5564 ATLASONC:PRKAB1ID44100ch12q24 WIKI:PRKAB1 protein kinase AMP-activated beta 2 non-catalytic subunit HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741 GENECARDS:PRKAB2 REACTOME:49386 ATLASONC:GC_PRKAB2 WIKI:PRKAB2 protein kinase AMP-activated gamma 1 non-catalytic subunit HUGO:PRKAG1 HGNC:9385 ENTREZ:5571 UNIPROT:P54619 GENECARDS:PRKAG1 REACTOME:49388 KEGG:5571 ATLASONC:GC_PRKAG1 WIKI:PRKAG1 protein kinase AMP-activated gamma 2 non-catalytic subunit HUGO:PRKAG2 HGNC:9386 ENTREZ:51422 UNIPROT:Q9UGJ0 GENECARDS:PRKAG2 REACTOME:49390 KEGG:51422 ATLASONC:GC_PRKAG2 WIKI:PRKAG2 HUGO:PRKAG3 HGNC:9387 ENTREZ:53632 UNIPROT:Q9UGI9 GENECARDS:PRKAG3 REACTOME:49392 KEGG:53632 ATLASONC:GC_PRKAG3 WIKI:PRKAG3 protein kinase cAMP-dependent regulatory type I alpha HUGO:PRKAR1A HGNC:9388 ENTREZ:5573 UNIPROT:P10644 GENECARDS:PRKAR1A REACTOME:57837 KEGG:5573 ATLASONC:PRKAR1AID387 WIKI:PRKAR1A protein kinase cAMP-dependent regulatory type I beta HUGO:PRKAR1B HGNC:9390 ENTREZ:5575 UNIPROT:P31321 GENECARDS:PRKAR1B REACTOME:57839 KEGG:5575 ATLASONC:GC_PRKAR1B WIKI:PRKAR1B protein kinase cAMP-dependent regulatory type II alpha HUGO:PRKAR2A HGNC:9391 ENTREZ:5576 UNIPROT:P13861 GENECARDS:PRKAR2A REACTOME:57841 KEGG:5576 ATLASONC:GC_PRKAR2A WIKI:PRKAR2A protein kinase cAMP-dependent regulatory type II beta HUGO:PRKAR2B HGNC:9392 ENTREZ:5577 UNIPROT:P31323 GENECARDS:PRKAR2B REACTOME:57843 KEGG:5577 ATLASONC:GC_PRKAR2B WIKI:PRKAR2B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: protein kinase AMP-activated beta 1 non-catalytic subunit HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478 GENECARDS:PRKAB1 REACTOME:49384 KEGG:5564 ATLASONC:PRKAB1ID44100ch12q24 WIKI:PRKAB1 protein kinase AMP-activated beta 2 non-catalytic subunit HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741 GENECARDS:PRKAB2 REACTOME:49386 ATLASONC:GC_PRKAB2 WIKI:PRKAB2 protein kinase AMP-activated gamma 1 non-catalytic subunit HUGO:PRKAG1 HGNC:9385 ENTREZ:5571 UNIPROT:P54619 GENECARDS:PRKAG1 REACTOME:49388 KEGG:5571 ATLASONC:GC_PRKAG1 WIKI:PRKAG1 protein kinase AMP-activated gamma 2 non-catalytic subunit HUGO:PRKAG2 HGNC:9386 ENTREZ:51422 UNIPROT:Q9UGJ0 GENECARDS:PRKAG2 REACTOME:49390 KEGG:51422 ATLASONC:GC_PRKAG2 WIKI:PRKAG2 HUGO:PRKAG3 HGNC:9387 ENTREZ:53632 UNIPROT:Q9UGI9 GENECARDS:PRKAG3 REACTOME:49392 KEGG:53632 ATLASONC:GC_PRKAG3 WIKI:PRKAG3 protein kinase cAMP-dependent regulatory type I alpha HUGO:PRKAR1A HGNC:9388 ENTREZ:5573 UNIPROT:P10644 GENECARDS:PRKAR1A REACTOME:57837 KEGG:5573 ATLASONC:PRKAR1AID387 WIKI:PRKAR1A protein kinase cAMP-dependent regulatory type I beta HUGO:PRKAR1B HGNC:9390 ENTREZ:5575 UNIPROT:P31321 GENECARDS:PRKAR1B REACTOME:57839 KEGG:5575 ATLASONC:GC_PRKAR1B WIKI:PRKAR1B protein kinase cAMP-dependent regulatory type II alpha HUGO:PRKAR2A HGNC:9391 ENTREZ:5576 UNIPROT:P13861 GENECARDS:PRKAR2A REACTOME:57841 KEGG:5576 ATLASONC:GC_PRKAR2A WIKI:PRKAR2A protein kinase cAMP-dependent regulatory type II beta HUGO:PRKAR2B HGNC:9392 ENTREZ:5577 UNIPROT:P31323 GENECARDS:PRKAR2B REACTOME:57843 KEGG:5577 ATLASONC:GC_PRKAR2B WIKI:PRKAR2B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PKA_R*"/> <bbox w="45.0" h="25.0" x="11545.0" y="1940.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s331_wnc1_wnc2_sa259"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: protein kinase AMP-activated beta 1 non-catalytic subunit HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478 GENECARDS:PRKAB1 REACTOME:49384 KEGG:5564 ATLASONC:PRKAB1ID44100ch12q24 WIKI:PRKAB1 protein kinase AMP-activated beta 2 non-catalytic subunit HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741 GENECARDS:PRKAB2 REACTOME:49386 ATLASONC:GC_PRKAB2 WIKI:PRKAB2 protein kinase AMP-activated gamma 1 non-catalytic subunit HUGO:PRKAG1 HGNC:9385 ENTREZ:5571 UNIPROT:P54619 GENECARDS:PRKAG1 REACTOME:49388 KEGG:5571 ATLASONC:GC_PRKAG1 WIKI:PRKAG1 protein kinase AMP-activated gamma 2 non-catalytic subunit HUGO:PRKAG2 HGNC:9386 ENTREZ:51422 UNIPROT:Q9UGJ0 GENECARDS:PRKAG2 REACTOME:49390 KEGG:51422 ATLASONC:GC_PRKAG2 WIKI:PRKAG2 HUGO:PRKAG3 HGNC:9387 ENTREZ:53632 UNIPROT:Q9UGI9 GENECARDS:PRKAG3 REACTOME:49392 KEGG:53632 ATLASONC:GC_PRKAG3 WIKI:PRKAG3 protein kinase cAMP-dependent regulatory type I alpha HUGO:PRKAR1A HGNC:9388 ENTREZ:5573 UNIPROT:P10644 GENECARDS:PRKAR1A REACTOME:57837 KEGG:5573 ATLASONC:PRKAR1AID387 WIKI:PRKAR1A protein kinase cAMP-dependent regulatory type I beta HUGO:PRKAR1B HGNC:9390 ENTREZ:5575 UNIPROT:P31321 GENECARDS:PRKAR1B REACTOME:57839 KEGG:5575 ATLASONC:GC_PRKAR1B WIKI:PRKAR1B protein kinase cAMP-dependent regulatory type II alpha HUGO:PRKAR2A HGNC:9391 ENTREZ:5576 UNIPROT:P13861 GENECARDS:PRKAR2A REACTOME:57841 KEGG:5576 ATLASONC:GC_PRKAR2A WIKI:PRKAR2A protein kinase cAMP-dependent regulatory type II beta HUGO:PRKAR2B HGNC:9392 ENTREZ:5577 UNIPROT:P31323 GENECARDS:PRKAR2B REACTOME:57843 KEGG:5577 ATLASONC:GC_PRKAR2B WIKI:PRKAR2B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: protein kinase AMP-activated beta 1 non-catalytic subunit HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478 GENECARDS:PRKAB1 REACTOME:49384 KEGG:5564 ATLASONC:PRKAB1ID44100ch12q24 WIKI:PRKAB1 protein kinase AMP-activated beta 2 non-catalytic subunit HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741 GENECARDS:PRKAB2 REACTOME:49386 ATLASONC:GC_PRKAB2 WIKI:PRKAB2 protein kinase AMP-activated gamma 1 non-catalytic subunit HUGO:PRKAG1 HGNC:9385 ENTREZ:5571 UNIPROT:P54619 GENECARDS:PRKAG1 REACTOME:49388 KEGG:5571 ATLASONC:GC_PRKAG1 WIKI:PRKAG1 protein kinase AMP-activated gamma 2 non-catalytic subunit HUGO:PRKAG2 HGNC:9386 ENTREZ:51422 UNIPROT:Q9UGJ0 GENECARDS:PRKAG2 REACTOME:49390 KEGG:51422 ATLASONC:GC_PRKAG2 WIKI:PRKAG2 HUGO:PRKAG3 HGNC:9387 ENTREZ:53632 UNIPROT:Q9UGI9 GENECARDS:PRKAG3 REACTOME:49392 KEGG:53632 ATLASONC:GC_PRKAG3 WIKI:PRKAG3 protein kinase cAMP-dependent regulatory type I alpha HUGO:PRKAR1A HGNC:9388 ENTREZ:5573 UNIPROT:P10644 GENECARDS:PRKAR1A REACTOME:57837 KEGG:5573 ATLASONC:PRKAR1AID387 WIKI:PRKAR1A protein kinase cAMP-dependent regulatory type I beta HUGO:PRKAR1B HGNC:9390 ENTREZ:5575 UNIPROT:P31321 GENECARDS:PRKAR1B REACTOME:57839 KEGG:5575 ATLASONC:GC_PRKAR1B WIKI:PRKAR1B protein kinase cAMP-dependent regulatory type II alpha HUGO:PRKAR2A HGNC:9391 ENTREZ:5576 UNIPROT:P13861 GENECARDS:PRKAR2A REACTOME:57841 KEGG:5576 ATLASONC:GC_PRKAR2A WIKI:PRKAR2A protein kinase cAMP-dependent regulatory type II beta HUGO:PRKAR2B HGNC:9392 ENTREZ:5577 UNIPROT:P31323 GENECARDS:PRKAR2B REACTOME:57843 KEGG:5577 ATLASONC:GC_PRKAR2B WIKI:PRKAR2B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PKA_R*"/> <bbox w="45.0" h="25.0" x="11592.0" y="1940.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s332_wnc1_wnc2_sa260"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: HUGO:PRKAA1 HGNC:9376 ENTREZ:5562 UNIPROT:Q13131 GENECARDS:PRKAA1 REACTOME:49380 KEGG:5562 ATLASONC:GC_PRKAA1 WIKI:PRKAA1 HUGO:PRKAA2 HGNC:9377 ENTREZ:5563 UNIPROT:P54646 GENECARDS:PRKAA2 REACTOME:49382 KEGG:5563 ATLASONC:GC_PRKAA2 WIKI:PRKAA2 HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 GENECARDS:PRKACG REACTOME:57849 KEGG:5568 ATLASONC:GC_PRKACG WIKI:PRKACG Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: HUGO:PRKAA1 HGNC:9376 ENTREZ:5562 UNIPROT:Q13131 GENECARDS:PRKAA1 REACTOME:49380 KEGG:5562 ATLASONC:GC_PRKAA1 WIKI:PRKAA1 HUGO:PRKAA2 HGNC:9377 ENTREZ:5563 UNIPROT:P54646 GENECARDS:PRKAA2 REACTOME:49382 KEGG:5563 ATLASONC:GC_PRKAA2 WIKI:PRKAA2 HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 GENECARDS:PRKACG REACTOME:57849 KEGG:5568 ATLASONC:GC_PRKACG WIKI:PRKACG Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PKA_C*"/> <bbox w="45.0" h="25.0" x="11547.0" y="1969.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s332_wnc1_wnc2_sa261"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: HUGO:PRKAA1 HGNC:9376 ENTREZ:5562 UNIPROT:Q13131 GENECARDS:PRKAA1 REACTOME:49380 KEGG:5562 ATLASONC:GC_PRKAA1 WIKI:PRKAA1 HUGO:PRKAA2 HGNC:9377 ENTREZ:5563 UNIPROT:P54646 GENECARDS:PRKAA2 REACTOME:49382 KEGG:5563 ATLASONC:GC_PRKAA2 WIKI:PRKAA2 HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 GENECARDS:PRKACG REACTOME:57849 KEGG:5568 ATLASONC:GC_PRKACG WIKI:PRKACG Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: HUGO:PRKAA1 HGNC:9376 ENTREZ:5562 UNIPROT:Q13131 GENECARDS:PRKAA1 REACTOME:49380 KEGG:5562 ATLASONC:GC_PRKAA1 WIKI:PRKAA1 HUGO:PRKAA2 HGNC:9377 ENTREZ:5563 UNIPROT:P54646 GENECARDS:PRKAA2 REACTOME:49382 KEGG:5563 ATLASONC:GC_PRKAA2 WIKI:PRKAA2 HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 GENECARDS:PRKACG REACTOME:57849 KEGG:5568 ATLASONC:GC_PRKACG WIKI:PRKACG Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PKA_C*"/> <bbox w="45.0" h="25.0" x="11595.0" y="1969.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s333_wnc1_wnc2_csa4" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PPP3CB:PPP3R* Identifiers_end References_begin: s_wnc2_re7(MAP:survival): PMID:17593948 PMID:18235236 s_wnc2_re9(MAP:survival): Calcineurin can be proteolysed which results in a truncated form of the catalytic subunit A. The truncated form is constitutively active and irreversible and does not require calcium and calmodulin for activation. PMID:17593948, PMID:14627704 s_wnc2_re50:(MAP:survival) PMID:16131541 s_wnc2_re68:(MAP:survival) PMID:15489953 References_end</body> </html> </notes> <label text="(Calcineurin)"/> <bbox w="100.0" h="120.0" x="10328.0" y="495.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s27_wnc1_wnc2_sa19"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, catalytic subunit, beta isozyme CALNB, "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)" HUGO:PPP3CB HGNC:9315 ENTREZ:5532 UNIPROT:P16298 GENECARDS:PPP3CB REACTOME:403037 KEGG:5532 ATLASONC:GC_PPP3CB WIKI:PPP3CB Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3CB"/> <bbox w="80.0" h="40.0" x="10341.0" y="507.0"/> <glyph class="state variable" id="_1ed2b2a8-192a-4893-8bf0-163d897f5b5b"> <state value="" variable="S197"/> <bbox w="30.0" h="10.0" x="10406.0" y="502.21478"/> </glyph> <glyph class="state variable" id="_2629db32-1a79-4725-ad51-cc151d4696f8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10336.0" y="502.0"/> </glyph> <glyph class="state variable" id="_b3096e8d-e5e4-4b29-be97-e1d45fc0b0fb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10336.0" y="522.0"/> </glyph> <glyph class="state variable" id="_c8179fa7-888b-448c-8f29-a6e0c1eda758"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10336.0" y="542.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s28_wnc1_wnc2_sa20"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, regulatory subunit B, alpha "protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform" HUGO:PPP3R1 HGNC:9317 ENTREZ:5534 UNIPROT:P63098 GENECARDS:PPP3R1 REACTOME:51292 KEGG:5534 ATLASONC:GC_PPP3R1 WIKI:PPP3R1 protein phosphatase 3, regulatory subunit B, beta HUGO:PPP3PR2 GENECARDS:PPP3PR2 WIKI:PPP3PR2 HUGO:PPP3R2 HGNC:9318 ENTREZ:5535 UNIPROT:Q96LZ3 GENECARDS:PPP3R2 KEGG:5535 ATLASONC:GC_PPP3R2 WIKI:PPP3R2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3R*"/> <bbox w="80.0" h="40.0" x="10341.0" y="550.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s334_wnc1_wnc2_csa31" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PPP3CB:PPP3R*:RCAN* Identifiers_end References_begin: s_wnc2_re50:(MAP:survival) PMID:16131541 References_end</body> </html> </notes> <label text="(Calcineurin/ RCAN)"/> <bbox w="105.0" h="173.0" x="10805.5" y="468.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s213_wnc1_wnc2_sa169"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, catalytic subunit, beta isozyme CALNB, "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)" HUGO:PPP3CB HGNC:9315 ENTREZ:5532 UNIPROT:P16298 GENECARDS:PPP3CB REACTOME:403037 KEGG:5532 ATLASONC:GC_PPP3CB WIKI:PPP3CB Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3CB"/> <bbox w="80.0" h="40.0" x="10818.5" y="480.0"/> <glyph class="state variable" id="_f3d1a145-181a-4a09-8d7b-39bbfb8537be"> <state value="" variable="S197"/> <bbox w="30.0" h="10.0" x="10883.5" y="475.21478"/> </glyph> <glyph class="state variable" id="_7fb42c39-3d31-464b-b6ba-9544d47b46a6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10813.5" y="475.0"/> </glyph> <glyph class="state variable" id="_3ef62510-4b2f-4606-b176-ee84b9b3bdd2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10813.5" y="495.0"/> </glyph> <glyph class="state variable" id="_256da08a-9f5a-4c46-b7be-ce9ea69b7cfb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10813.5" y="515.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s214_wnc1_wnc2_sa170"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, regulatory subunit B, alpha "protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform" HUGO:PPP3R1 HGNC:9317 ENTREZ:5534 UNIPROT:P63098 GENECARDS:PPP3R1 REACTOME:51292 KEGG:5534 ATLASONC:GC_PPP3R1 WIKI:PPP3R1 protein phosphatase 3, regulatory subunit B, beta HUGO:PPP3PR2 GENECARDS:PPP3PR2 WIKI:PPP3PR2 HUGO:PPP3R2 HGNC:9318 ENTREZ:5535 UNIPROT:Q96LZ3 GENECARDS:PPP3R2 KEGG:5535 ATLASONC:GC_PPP3R2 WIKI:PPP3R2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3R*"/> <bbox w="80.0" h="40.0" x="10818.5" y="523.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s250_wnc1_wnc2_sa171"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: regulator of calcineurin 1 "Down syndrome critical region gene 1", DSCR1 HUGO:RCAN1 HGNC:3040 ENTREZ:1827 UNIPROT:P53805 GENECARDS:RCAN1 KEGG:1827 ATLASONC:GC_RCAN1 WIKI:RCAN1 regulator of calcineurin 2 HUGO:RCAN2 HGNC:3041 ENTREZ:10231 UNIPROT:Q14206 GENECARDS:RCAN2 KEGG:10231 ATLASONC:GC_RCAN2 WIKI:RCAN2 RCAN family member 3 "Down syndrome critical region gene 1-like 2", DSCR1L2 HUGO:RCAN3 HGNC:3042 ENTREZ:11123 UNIPROT:Q9UKA8 GENECARDS:RCAN3 KEGG:11123 ATLASONC:GC_RCAN3 WIKI:RCAN3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RCAN*"/> <bbox w="80.0" h="40.0" x="10818.5" y="566.0"/> <glyph class="state variable" id="_dff7be98-2a12-47bc-be72-c529b92d8925"> <state value="" variable="S94"/> <bbox w="25.0" h="10.0" x="10806.0" y="561.0"/> </glyph> <glyph class="state variable" id="_ba938119-d899-4558-b2e3-55d8afcaff87"> <state value="" variable="S136"/> <bbox w="30.0" h="10.0" x="10883.5" y="561.2148"/> </glyph> <glyph class="state variable" id="_b45cb471-a15f-484f-85f1-5d08b32d5a54"> <state value="P" variable="T192"/> <bbox w="35.0" h="10.0" x="10880.382" y="601.0"/> </glyph> <glyph class="state variable" id="_a8bb0f18-09ed-45a7-8a9d-d230193b55c0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10870.068" y="561.0"/> </glyph> <glyph class="state variable" id="_8bdf0f4d-3bb7-4a4f-bf27-539d7b372aab"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10836.932" y="561.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s335_wnc1_wnc2_csa8" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CAIN*:PPP3CB:PPP3R* Identifiers_end</body> </html> </notes> <label text="(Calcineurin/CAIN)"/> <bbox w="108.0" h="164.0" x="10019.5" y="700.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s45_wnc1_wnc2_sa34"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, catalytic subunit, beta isozyme CALNB, "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)" HUGO:PPP3CB HGNC:9315 ENTREZ:5532 UNIPROT:P16298 GENECARDS:PPP3CB REACTOME:403037 KEGG:5532 ATLASONC:GC_PPP3CB WIKI:PPP3CB Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3CB"/> <bbox w="80.0" h="40.0" x="10032.5" y="756.0"/> <glyph class="state variable" id="_b374c22c-1538-476d-b816-6b005abbe5d5"> <state value="" variable="S197"/> <bbox w="30.0" h="10.0" x="10097.5" y="751.2148"/> </glyph> <glyph class="state variable" id="_77ca2710-1e44-49d1-9c26-539afce6fb98"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10027.5" y="751.0"/> </glyph> <glyph class="state variable" id="_bb41008f-e4d4-4fbb-9c58-45a75066fa59"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10027.5" y="771.0"/> </glyph> <glyph class="state variable" id="_56404fe4-9ab6-4cd5-907a-d1b7644f2e78"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10027.5" y="791.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s46_wnc1_wnc2_sa35"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, regulatory subunit B, alpha "protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform" HUGO:PPP3R1 HGNC:9317 ENTREZ:5534 UNIPROT:P63098 GENECARDS:PPP3R1 REACTOME:51292 KEGG:5534 ATLASONC:GC_PPP3R1 WIKI:PPP3R1 protein phosphatase 3, regulatory subunit B, beta HUGO:PPP3PR2 GENECARDS:PPP3PR2 WIKI:PPP3PR2 HUGO:PPP3R2 HGNC:9318 ENTREZ:5535 UNIPROT:Q96LZ3 GENECARDS:PPP3R2 KEGG:5535 ATLASONC:GC_PPP3R2 WIKI:PPP3R2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3R*"/> <bbox w="80.0" h="40.0" x="10032.5" y="799.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s47_wnc1_wnc2_sa36"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CABIN1 HUGO:CABIN1 HGNC:24187 ENTREZ:23523 UNIPROT:Q9Y6J0 GENECARDS:CABIN1 KEGG:23523 ATLASONC:GC_CABIN1 WIKI:CABIN1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20514436 References_end</body> </html> </notes> <label text="CAIN*"/> <bbox w="80.0" h="40.0" x="10031.5" y="713.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s336_wnc1_wnc2_csa6" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Ca2+:Calmodulin*:PPP3CB:PPP3R* Identifiers_end References_begin: s_wnc2_re7(MAP:survival): PMID:17593948 PMID:18235236 s_wnc2_re26:(MAP:survival) PMID:15036616, PMID:14741051 s_wnc2_re49:(MAP:survival) PMID:2550447, PMID:19608982 s_wnc2_re53:(MAP:survival) PMID:19136967 s_wnc2_re66:(MAP:survival) PMID:11796223 References_end</body> </html> </notes> <label text="(Calcineurin/ Calmodulin/ Ca2+)"/> <bbox w="102.0" h="216.0" x="10416.0" y="711.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s34_wnc1_wnc2_sa23"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, catalytic subunit, beta isozyme CALNB, "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)" HUGO:PPP3CB HGNC:9315 ENTREZ:5532 UNIPROT:P16298 GENECARDS:PPP3CB REACTOME:403037 KEGG:5532 ATLASONC:GC_PPP3CB WIKI:PPP3CB Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3CB"/> <bbox w="80.0" h="40.0" x="10425.5" y="717.5"/> <glyph class="state variable" id="_73bf97f9-3849-4572-9fe1-4af273cadb66"> <state value="" variable="S197"/> <bbox w="30.0" h="10.0" x="10490.5" y="712.7148"/> </glyph> <glyph class="state variable" id="_fbc4329c-3199-4ba5-9795-1c32b0df000f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10420.5" y="712.5"/> </glyph> <glyph class="state variable" id="_d2070abc-b002-4543-8e8e-fcd777c641bb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10420.5" y="732.5"/> </glyph> <glyph class="state variable" id="_52c5ed3a-4145-44c3-92cf-a53149da34d4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10420.5" y="752.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s35_wnc1_wnc2_sa24"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, regulatory subunit B, alpha "protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform" HUGO:PPP3R1 HGNC:9317 ENTREZ:5534 UNIPROT:P63098 GENECARDS:PPP3R1 REACTOME:51292 KEGG:5534 ATLASONC:GC_PPP3R1 WIKI:PPP3R1 protein phosphatase 3, regulatory subunit B, beta HUGO:PPP3PR2 GENECARDS:PPP3PR2 WIKI:PPP3PR2 HUGO:PPP3R2 HGNC:9318 ENTREZ:5535 UNIPROT:Q96LZ3 GENECARDS:PPP3R2 KEGG:5535 ATLASONC:GC_PPP3R2 WIKI:PPP3R2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3R*"/> <bbox w="80.0" h="40.0" x="10425.5" y="760.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s36_wnc1_wnc2_sa25"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: calmodulin 1 (phosphorylase kinase, delta) CALML2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 2 (phosphorylase kinase, delta) HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 3 (phosphorylase kinase, delta) HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Calmodulin*"/> <bbox w="80.0" h="40.0" x="10425.5" y="803.0"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc2_s37_wnc1_wnc2_sa26"> <label text="Ca2+"/> <bbox w="25.0" h="25.0" x="10453.25" y="844.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s337_wnc1_wnc2_csa29" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Ca2+:Calmodulin*:PPP3R* Identifiers_end References_begin: s_wnc2_re49:(MAP:survival) PMID:2550447, PMID:19608982 References_end</body> </html> </notes> <label text="(Calcineurin/ Calmodulin/ Ca2+)"/> <bbox w="102.0" h="216.0" x="10416.5" y="976.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s197_wnc1_wnc2_sa160"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, regulatory subunit B, alpha "protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform" HUGO:PPP3R1 HGNC:9317 ENTREZ:5534 UNIPROT:P63098 GENECARDS:PPP3R1 REACTOME:51292 KEGG:5534 ATLASONC:GC_PPP3R1 WIKI:PPP3R1 protein phosphatase 3, regulatory subunit B, beta HUGO:PPP3PR2 GENECARDS:PPP3PR2 WIKI:PPP3PR2 HUGO:PPP3R2 HGNC:9318 ENTREZ:5535 UNIPROT:Q96LZ3 GENECARDS:PPP3R2 KEGG:5535 ATLASONC:GC_PPP3R2 WIKI:PPP3R2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3R*"/> <bbox w="80.0" h="40.0" x="10426.0" y="1025.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s198_wnc1_wnc2_sa161"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: calmodulin 1 (phosphorylase kinase, delta) CALML2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 2 (phosphorylase kinase, delta) HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 3 (phosphorylase kinase, delta) HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Calmodulin*"/> <bbox w="80.0" h="40.0" x="10426.0" y="1068.0"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc2_s199_wnc1_wnc2_sa162"> <label text="Ca2+"/> <bbox w="25.0" h="25.0" x="10453.75" y="1109.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s338_wnc1_wnc2_csa39" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PPP3CB:PPP3R* Identifiers_end References_begin: s_wnc2_re68:(MAP:survival) PMID:15489953 References_end</body> </html> </notes> <label text="(Calcineurin)"/> <bbox w="100.0" h="120.0" x="10151.5" y="1998.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s271_wnc1_wnc2_sa214"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, catalytic subunit, beta isozyme CALNB, "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)" HUGO:PPP3CB HGNC:9315 ENTREZ:5532 UNIPROT:P16298 GENECARDS:PPP3CB REACTOME:403037 KEGG:5532 ATLASONC:GC_PPP3CB WIKI:PPP3CB Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3CB"/> <bbox w="80.0" h="40.0" x="10164.5" y="2010.0"/> <glyph class="state variable" id="_c6daa54a-af16-4268-a407-f42b4e67a095"> <state value="" variable="S197"/> <bbox w="30.0" h="10.0" x="10229.5" y="2005.2147"/> </glyph> <glyph class="state variable" id="_1257ed6e-aef4-4d34-8ce5-a903c0635247"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="10154.5" y="2005.0"/> </glyph> <glyph class="state variable" id="_d70c3547-5aa0-4bad-9cd0-aece2b8ed5e7"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="10154.5" y="2025.0"/> </glyph> <glyph class="state variable" id="_af50ef6c-dc0f-49b0-b490-42450cdfeaa6"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="10154.5" y="2045.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s270_wnc1_wnc2_sa215"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, regulatory subunit B, alpha "protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform" HUGO:PPP3R1 HGNC:9317 ENTREZ:5534 UNIPROT:P63098 GENECARDS:PPP3R1 REACTOME:51292 KEGG:5534 ATLASONC:GC_PPP3R1 WIKI:PPP3R1 protein phosphatase 3, regulatory subunit B, beta HUGO:PPP3PR2 GENECARDS:PPP3PR2 WIKI:PPP3PR2 HUGO:PPP3R2 HGNC:9318 ENTREZ:5535 UNIPROT:Q96LZ3 GENECARDS:PPP3R2 KEGG:5535 ATLASONC:GC_PPP3R2 WIKI:PPP3R2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3R*"/> <bbox w="80.0" h="40.0" x="10164.5" y="2053.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s339_wnc1_wnc2_csa23" compartmentRef="wnc1_wnc2_c4_wnc1_wnc2_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Ca2+:Calmodulin*:KPNB1:NFAT*:PPP3CB:PPP3R*:Tubulin-_alpha_* Identifiers_end References_begin: s_wnc2_re43:(MAP:survival) PMID:19136967 References_end</body> </html> </notes> <label text="(Calcineurin/Calmodulin/Ca2+ KPNB1/Tubulin-α)"/> <bbox w="186.0" h="266.0" x="11059.25" y="1739.5"/> <glyph class="macromolecule" id="wnc1_wnc2_s104_wnc1_wnc2_sa101"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="11068.75" y="1899.5"/> <glyph class="state variable" id="_7363ef92-ae5c-4fc1-9c23-df402b0590db"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11143.75" y="1922.7843"/> </glyph> <glyph class="state variable" id="_174121e5-073d-47f0-8c83-ffb82519bf90"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11143.75" y="1934.5"/> </glyph> <glyph class="state variable" id="_45f57691-0793-4005-858b-7a9c604d4347"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11120.318" y="1934.5"/> </glyph> <glyph class="state variable" id="_c08e5891-609f-49cb-b55b-0731711765f5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11063.75" y="1894.5"/> </glyph> <glyph class="state variable" id="_1363c6d5-c144-48ea-9e95-b600040bd4d3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11087.182" y="1894.5"/> </glyph> <glyph class="state variable" id="_2eddffbf-4a86-487c-93d2-311862063fc7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11103.75" y="1894.5"/> </glyph> <glyph class="state variable" id="_f709e72d-6474-4347-9de9-12fdaca266aa"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11063.75" y="1914.5"/> </glyph> <glyph class="state variable" id="_c015681d-1e4a-4035-a5a0-c81ba17416d3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11120.318" y="1894.5"/> </glyph> <glyph class="state variable" id="_a6f7404b-f5a7-49f3-8e71-a80c1aa16595"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11143.75" y="1894.5"/> </glyph> <glyph class="state variable" id="_89609688-cc71-4746-85e2-39632f4b0fd7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11143.75" y="1906.2157"/> </glyph> <glyph class="state variable" id="_1acd96b1-1578-48db-8f0a-99eae1b39f52"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11143.75" y="1914.5"/> </glyph> <glyph class="state variable" id="_b62cb7f3-124b-4d35-9ba5-93f80799cbd1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11063.75" y="1894.5"/> </glyph> <glyph class="state variable" id="_5ef0b96d-9264-4d11-bc5b-683f5206e6bc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11063.75" y="1906.2157"/> </glyph> <glyph class="state variable" id="_dd492c63-96e0-4cce-8214-41f6980a4698"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11063.75" y="1922.7843"/> </glyph> <glyph class="state variable" id="_5f99f0c2-e3ec-436a-a6f4-b91b0f926a69"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="11067.406" y="1934.5"/> </glyph> <glyph class="state variable" id="_03f5c25c-4f0a-41d3-8eeb-27aff57ab4b3"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="11087.606" y="1934.5"/> </glyph> <glyph class="state variable" id="_42189396-e09e-4c8b-8955-424c40d4b87c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11103.75" y="1934.5"/> </glyph> <glyph class="state variable" id="_0703f5e9-78c2-4ab8-b720-9505deda6dc0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11087.182" y="1934.5"/> </glyph> <glyph class="state variable" id="_9f3bfa68-af7a-4d07-97ec-c8b14a1b7a45"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11063.75" y="1934.5"/> </glyph> <glyph class="state variable" id="_88583090-9cd9-4aba-b971-71b3f54da464"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11063.75" y="1914.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s124_wnc1_wnc2_sa102"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, catalytic subunit, beta isozyme CALNB, "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)" HUGO:PPP3CB HGNC:9315 ENTREZ:5532 UNIPROT:P16298 GENECARDS:PPP3CB REACTOME:403037 KEGG:5532 ATLASONC:GC_PPP3CB WIKI:PPP3CB Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3CB"/> <bbox w="80.0" h="40.0" x="11068.75" y="1746.0"/> <glyph class="state variable" id="_40dfaf32-dabe-4fd7-99f4-1716712fc980"> <state value="" variable="S197"/> <bbox w="30.0" h="10.0" x="11133.75" y="1741.2147"/> </glyph> <glyph class="state variable" id="_84f55814-662f-473c-9302-327ef3ac66fc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11063.75" y="1741.0"/> </glyph> <glyph class="state variable" id="_d5874ba6-9dc4-49b8-9f27-1a44a8908ab2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11063.75" y="1761.0"/> </glyph> <glyph class="state variable" id="_16ea9306-e8fb-47bc-bc63-54068db7f6ed"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11063.75" y="1781.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s125_wnc1_wnc2_sa103"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, regulatory subunit B, alpha "protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform" HUGO:PPP3R1 HGNC:9317 ENTREZ:5534 UNIPROT:P63098 GENECARDS:PPP3R1 REACTOME:51292 KEGG:5534 ATLASONC:GC_PPP3R1 WIKI:PPP3R1 protein phosphatase 3, regulatory subunit B, beta HUGO:PPP3PR2 GENECARDS:PPP3PR2 WIKI:PPP3PR2 HUGO:PPP3R2 HGNC:9318 ENTREZ:5535 UNIPROT:Q96LZ3 GENECARDS:PPP3R2 KEGG:5535 ATLASONC:GC_PPP3R2 WIKI:PPP3R2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3R*"/> <bbox w="80.0" h="40.0" x="11068.75" y="1789.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s126_wnc1_wnc2_sa104"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: calmodulin 1 (phosphorylase kinase, delta) CALML2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 2 (phosphorylase kinase, delta) HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 3 (phosphorylase kinase, delta) HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Calmodulin*"/> <bbox w="80.0" h="40.0" x="11068.75" y="1831.5"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc2_s127_wnc1_wnc2_sa105"> <label text="Ca2+"/> <bbox w="25.0" h="25.0" x="11096.5" y="1872.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s157_wnc1_wnc2_sa125"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: karyopherin (importin) beta 1 HUGO:KPNB1 HGNC:6400 ENTREZ:3837 UNIPROT:Q14974 GENECARDS:KPNB1 REACTOME:57343 KEGG:3837 ATLASONC:GC_KPNB1 WIKI:KPNB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="KPNB1"/> <bbox w="80.0" h="40.0" x="11153.5" y="1746.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s158_wnc1_wnc2_sa126"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tubulin, alpha 1a HUGO:TUBA1A HGNC:20766 ENTREZ:7846 UNIPROT:Q71U36 GENECARDS:TUBA1A REACTOME:191692 KEGG:7846 ATLASONC:GC_TUBA1A WIKI:TUBA1A SwissProt: Q71U36 tubulin, alpha 1b HUGO:TUBA1B HGNC:18809 ENTREZ:10376 UNIPROT:P68363 GENECARDS:TUBA1B REACTOME:191693 KEGG:10376 ATLASONC:GC_TUBA1B WIKI:TUBA1B SwissProt: P68363 tubulin, alpha 1c HUGO:TUBA1C HGNC:20768 ENTREZ:84790 UNIPROT:Q9BQE3 GENECARDS:TUBA1C REACTOME:65667 KEGG:84790 ATLASONC:GC_TUBA1C WIKI:TUBA1C SwissProt: Q9BQE3 tubulin, alpha 3c HUGO:TUBA3C HGNC:12408 ENTREZ:7278 UNIPROT:Q13748 GENECARDS:TUBA3C REACTOME:154750 KEGG:7278 WIKI:TUBA3C SwissProt: Q13748 tubulin, alpha 3d HUGO:TUBA3D HGNC:24071 ENTREZ:113457 UNIPROT:Q13748 GENECARDS:TUBA3D REACTOME:154750 KEGG:113457 WIKI:TUBA3D tubulin, alpha 3e HUGO:TUBA3E HGNC:20765 ENTREZ:112714 UNIPROT:Q6PEY2 GENECARDS:TUBA3E WIKI:TUBA3E SwissProt: Q6PEY2 tubulin, alpha 4a HUGO:TUBA4A HGNC:12407 ENTREZ:7277 UNIPROT:P68366 GENECARDS:TUBA4A REACTOME:191690 KEGG:7277 ATLASONC:GC_TUBA4A WIKI:TUBA4A SwissProt: P68366 tubulin, alpha 8 HUGO:TUBA8 HGNC:12410 ENTREZ:51807 UNIPROT:Q9NY65 GENECARDS:TUBA8 KEGG:51807 WIKI:TUBA8 SwissProt: Q9NY65 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Tubulin-α*"/> <bbox w="80.0" h="40.0" x="11153.5" y="1788.5"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s340_wnc1_wnc2_csa37" compartmentRef="wnc1_wnc2_c4_wnc1_wnc2_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Ca2+:Calmodulin*:PPP3CB:PPP3R* Identifiers_end</body> </html> </notes> <label text="(Calcineurin/Calmodulin)"/> <bbox w="109.0" h="189.0" x="11321.0" y="1732.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s236_wnc1_wnc2_sa188"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, catalytic subunit, beta isozyme CALNB, "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)" HUGO:PPP3CB HGNC:9315 ENTREZ:5532 UNIPROT:P16298 GENECARDS:PPP3CB REACTOME:403037 KEGG:5532 ATLASONC:GC_PPP3CB WIKI:PPP3CB Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3CB"/> <bbox w="80.0" h="40.0" x="11338.0" y="1741.5"/> <glyph class="state variable" id="_ef17d99f-5c00-49b9-b158-19a975fa34de"> <state value="" variable="S197"/> <bbox w="30.0" h="10.0" x="11403.0" y="1736.7147"/> </glyph> <glyph class="state variable" id="_a0561e23-3324-4c9a-adf9-9e303636ec68"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11333.0" y="1736.5"/> </glyph> <glyph class="state variable" id="_ad3bafce-97bb-4c6d-b6aa-29e86b9be589"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11333.0" y="1756.5"/> </glyph> <glyph class="state variable" id="_63f69e85-af1f-4a9b-899d-951ffec383c6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11333.0" y="1776.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s237_wnc1_wnc2_sa189"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, regulatory subunit B, alpha "protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform" HUGO:PPP3R1 HGNC:9317 ENTREZ:5534 UNIPROT:P63098 GENECARDS:PPP3R1 REACTOME:51292 KEGG:5534 ATLASONC:GC_PPP3R1 WIKI:PPP3R1 protein phosphatase 3, regulatory subunit B, beta HUGO:PPP3PR2 GENECARDS:PPP3PR2 WIKI:PPP3PR2 HUGO:PPP3R2 HGNC:9318 ENTREZ:5535 UNIPROT:Q96LZ3 GENECARDS:PPP3R2 KEGG:5535 ATLASONC:GC_PPP3R2 WIKI:PPP3R2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3R*"/> <bbox w="80.0" h="40.0" x="11338.0" y="1784.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s238_wnc1_wnc2_sa190"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: calmodulin 1 (phosphorylase kinase, delta) CALML2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 2 (phosphorylase kinase, delta) HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 3 (phosphorylase kinase, delta) HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Calmodulin*"/> <bbox w="80.0" h="40.0" x="11338.0" y="1827.0"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc2_s239_wnc1_wnc2_sa191"> <label text="Ca2+"/> <bbox w="25.0" h="25.0" x="11365.75" y="1868.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s341_wnc1_wnc2_csa24" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Ca2+:Calmodulin*:KPNB1:NFAT*:PPP3CB:PPP3R*:TNPO1:Tubulin-_alpha_* Identifiers_end References_begin: s_wnc2_re44(MAP:survival): Tubulin-alpha binds both NFAT and KPNB1 after dephosphorylation of NFAT. PMID:21278340 TNPO1 is a transport protein that helps in the import of proteins into the nucleus. Although it has been described with associated with NRON, it is most likely that it binds first to NFAT complex, making this complex ready for import, then NRON can bind to this complex to hinder the import of the complex PMID:21709260 s_wnc2_re43:(MAP:survival) PMID:19136967 s_wnc2_re47(MAP:survival): LRKK2 mediates binding of NFAT to NRON and other components, but this is independent of its kinase activity and independent of the phosphorylation status of NFAT PMID:21983832 References_end</body> </html> </notes> <label text="(Calcineurin/Calmodulin/Ca2+ KPNB1/Tubulin-α)"/> <bbox w="179.0" h="261.0" x="11062.0" y="1331.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s139_wnc1_wnc2_sa111"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="11071.5" y="1491.0"/> <glyph class="state variable" id="_2fc99f72-503f-403b-a388-c81593842d5a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11146.5" y="1514.2843"/> </glyph> <glyph class="state variable" id="_5696a0e6-0c9a-4c27-a186-d982655a3cff"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11146.5" y="1526.0"/> </glyph> <glyph class="state variable" id="_108dc65a-531a-4df6-b3fb-23abb9548f78"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11123.068" y="1526.0"/> </glyph> <glyph class="state variable" id="_1f8e897c-053c-43ca-9990-a39a9be96160"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11066.5" y="1486.0"/> </glyph> <glyph class="state variable" id="_7753a61b-cf48-4b52-8c5c-398171acb293"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11089.932" y="1486.0"/> </glyph> <glyph class="state variable" id="_31937eda-7c07-4106-a0a2-3f3f9ef80a63"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11106.5" y="1486.0"/> </glyph> <glyph class="state variable" id="_d8cbb3e6-c568-4a86-b6c2-26751048cf14"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11066.5" y="1506.0"/> </glyph> <glyph class="state variable" id="_24bd0d53-8c92-4e1f-a574-67fc0760176c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11123.068" y="1486.0"/> </glyph> <glyph class="state variable" id="_d0e47153-21c0-4a09-8cfa-1e962e9d56a2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11146.5" y="1486.0"/> </glyph> <glyph class="state variable" id="_15fd118a-71de-418f-bb1e-79b4bac40813"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11146.5" y="1497.7157"/> </glyph> <glyph class="state variable" id="_632eecd4-87f4-4236-81c5-c0858e3d174e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11146.5" y="1506.0"/> </glyph> <glyph class="state variable" id="_692823be-74c9-4df2-83ce-80e8e03bf687"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11066.5" y="1486.0"/> </glyph> <glyph class="state variable" id="_c443cfce-bb29-4475-b6c1-c2e389ee4151"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11066.5" y="1497.7157"/> </glyph> <glyph class="state variable" id="_ac166aae-2181-4422-a8a1-fbe8b0029ce5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11066.5" y="1514.2843"/> </glyph> <glyph class="state variable" id="_aebe457f-ac94-43f5-a3ad-f57186ac81f3"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="11070.156" y="1526.0"/> </glyph> <glyph class="state variable" id="_de5f0a1a-0ef9-4951-baf5-1d5271a93aa1"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="11090.356" y="1526.0"/> </glyph> <glyph class="state variable" id="_84e21ca5-68e1-42fe-9e15-656e220850da"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11106.5" y="1526.0"/> </glyph> <glyph class="state variable" id="_615196b8-f53c-46b2-a889-95a72b98b863"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11089.932" y="1526.0"/> </glyph> <glyph class="state variable" id="_ffe980f3-56ef-44d7-8e3f-6b2ac8f826ac"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11066.5" y="1526.0"/> </glyph> <glyph class="state variable" id="_b4b82848-903e-47c5-8069-64360e1dc983"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11066.5" y="1506.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s140_wnc1_wnc2_sa112"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, catalytic subunit, beta isozyme CALNB, "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)" HUGO:PPP3CB HGNC:9315 ENTREZ:5532 UNIPROT:P16298 GENECARDS:PPP3CB REACTOME:403037 KEGG:5532 ATLASONC:GC_PPP3CB WIKI:PPP3CB Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3CB"/> <bbox w="80.0" h="40.0" x="11071.5" y="1337.5"/> <glyph class="state variable" id="_a050c94d-413f-4d44-9215-fce3462a05f6"> <state value="" variable="S197"/> <bbox w="30.0" h="10.0" x="11136.5" y="1332.7147"/> </glyph> <glyph class="state variable" id="_2afa378d-ba68-4653-a882-42bba531c1b0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11066.5" y="1332.5"/> </glyph> <glyph class="state variable" id="_0dd56969-92cd-484e-90a3-78a9b20694e3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11066.5" y="1352.5"/> </glyph> <glyph class="state variable" id="_bf403aa5-9b47-4bd6-a465-69615545251f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11066.5" y="1372.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s141_wnc1_wnc2_sa113"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, regulatory subunit B, alpha "protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform" HUGO:PPP3R1 HGNC:9317 ENTREZ:5534 UNIPROT:P63098 GENECARDS:PPP3R1 REACTOME:51292 KEGG:5534 ATLASONC:GC_PPP3R1 WIKI:PPP3R1 protein phosphatase 3, regulatory subunit B, beta HUGO:PPP3PR2 GENECARDS:PPP3PR2 WIKI:PPP3PR2 HUGO:PPP3R2 HGNC:9318 ENTREZ:5535 UNIPROT:Q96LZ3 GENECARDS:PPP3R2 KEGG:5535 ATLASONC:GC_PPP3R2 WIKI:PPP3R2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3R*"/> <bbox w="80.0" h="40.0" x="11071.5" y="1380.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s142_wnc1_wnc2_sa114"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: calmodulin 1 (phosphorylase kinase, delta) CALML2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 2 (phosphorylase kinase, delta) HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 3 (phosphorylase kinase, delta) HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Calmodulin*"/> <bbox w="80.0" h="40.0" x="11071.5" y="1423.0"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc2_s143_wnc1_wnc2_sa115"> <label text="Ca2+"/> <bbox w="25.0" h="25.0" x="11099.25" y="1464.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s145_wnc1_wnc2_sa116"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: karyopherin (importin) beta 1 HUGO:KPNB1 HGNC:6400 ENTREZ:3837 UNIPROT:Q14974 GENECARDS:KPNB1 REACTOME:57343 KEGG:3837 ATLASONC:GC_KPNB1 WIKI:KPNB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="KPNB1"/> <bbox w="80.0" h="40.0" x="11155.25" y="1340.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s144_wnc1_wnc2_sa117"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tubulin, alpha 1a HUGO:TUBA1A HGNC:20766 ENTREZ:7846 UNIPROT:Q71U36 GENECARDS:TUBA1A REACTOME:191692 KEGG:7846 ATLASONC:GC_TUBA1A WIKI:TUBA1A SwissProt: Q71U36 tubulin, alpha 1b HUGO:TUBA1B HGNC:18809 ENTREZ:10376 UNIPROT:P68363 GENECARDS:TUBA1B REACTOME:191693 KEGG:10376 ATLASONC:GC_TUBA1B WIKI:TUBA1B SwissProt: P68363 tubulin, alpha 1c HUGO:TUBA1C HGNC:20768 ENTREZ:84790 UNIPROT:Q9BQE3 GENECARDS:TUBA1C REACTOME:65667 KEGG:84790 ATLASONC:GC_TUBA1C WIKI:TUBA1C SwissProt: Q9BQE3 tubulin, alpha 3c HUGO:TUBA3C HGNC:12408 ENTREZ:7278 UNIPROT:Q13748 GENECARDS:TUBA3C REACTOME:154750 KEGG:7278 WIKI:TUBA3C SwissProt: Q13748 tubulin, alpha 3d HUGO:TUBA3D HGNC:24071 ENTREZ:113457 UNIPROT:Q13748 GENECARDS:TUBA3D REACTOME:154750 KEGG:113457 WIKI:TUBA3D tubulin, alpha 3e HUGO:TUBA3E HGNC:20765 ENTREZ:112714 UNIPROT:Q6PEY2 GENECARDS:TUBA3E WIKI:TUBA3E SwissProt: Q6PEY2 tubulin, alpha 4a HUGO:TUBA4A HGNC:12407 ENTREZ:7277 UNIPROT:P68366 GENECARDS:TUBA4A REACTOME:191690 KEGG:7277 ATLASONC:GC_TUBA4A WIKI:TUBA4A SwissProt: P68366 tubulin, alpha 8 HUGO:TUBA8 HGNC:12410 ENTREZ:51807 UNIPROT:Q9NY65 GENECARDS:TUBA8 KEGG:51807 WIKI:TUBA8 SwissProt: Q9NY65 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Tubulin-α*"/> <bbox w="80.0" h="40.0" x="11155.25" y="1382.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s210_wnc1_wnc2_sa167"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transportin 1 "karyopherin (importin) beta 2", KPNB2 HUGO:TNPO1 HGNC:6401 ENTREZ:3842 UNIPROT:Q92973 GENECARDS:TNPO1 REACTOME:57345 KEGG:3842 ATLASONC:GC_TNPO1 WIKI:TNPO1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TNPO1"/> <bbox w="80.0" h="40.0" x="11152.5" y="1423.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s342_wnc1_wnc2_csa25" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:KPNB1:NFAT*:PPP3CB_sub_trunc_endsub_*:PPP3R*:TNPO1:Tubulin-_alpha_* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Constitutively active PMID:17662023, PMID:17593948, PMID:14627704 s_wnc2_re45(MAP:survival): Tubulin-alpha binds both NFAT and KPNB1 after dephosphorylation of NFAT. PMID:21278340 TNPO1 is a transport protein that helps in the import of proteins into the nucleus. Although it has been described with associated with NRON, it is most likely that it binds first to NFAT complex, making this complex ready for import, then NRON can bind to this complex to hinder the import of the complex PMID:21709260 References_end</body> </html> </notes> <label text="(CnA_trun/CnB/KPNB1/Tubulinα)"/> <bbox w="196.0" h="195.0" x="10830.75" y="1331.5"/> <glyph class="macromolecule" id="wnc1_wnc2_s147_wnc1_wnc2_sa118"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, catalytic subunit, beta isozyme CALNB, "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)" HUGO:PPP3CB HGNC:9315 ENTREZ:5532 UNIPROT:P16298 GENECARDS:PPP3CB REACTOME:403037 KEGG:5532 ATLASONC:GC_PPP3CB WIKI:PPP3CB Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3CBtrunc*"/> <bbox w="80.0" h="40.0" x="10928.75" y="1342.5"/> <glyph class="unit of information" id="_e799fca4-7c68-4c50-bda7-bbdb2ca735f5"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10943.75" y="1337.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s148_wnc1_wnc2_sa119"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, regulatory subunit B, alpha "protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform" HUGO:PPP3R1 HGNC:9317 ENTREZ:5534 UNIPROT:P63098 GENECARDS:PPP3R1 REACTOME:51292 KEGG:5534 ATLASONC:GC_PPP3R1 WIKI:PPP3R1 protein phosphatase 3, regulatory subunit B, beta HUGO:PPP3PR2 GENECARDS:PPP3PR2 WIKI:PPP3PR2 HUGO:PPP3R2 HGNC:9318 ENTREZ:5535 UNIPROT:Q96LZ3 GENECARDS:PPP3R2 KEGG:5535 ATLASONC:GC_PPP3R2 WIKI:PPP3R2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3R*"/> <bbox w="80.0" h="40.0" x="10928.75" y="1385.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s149_wnc1_wnc2_sa120"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="10929.75" y="1438.5"/> <glyph class="state variable" id="_05d5f5bd-603e-49aa-afdf-5273cc5bd5a6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11004.75" y="1461.7843"/> </glyph> <glyph class="state variable" id="_3a6b9a7f-d1c4-4fdb-832e-87d2c0b2b051"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11004.75" y="1473.5"/> </glyph> <glyph class="state variable" id="_c81def47-2706-4ae6-9c2d-20f29440c762"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10981.318" y="1473.5"/> </glyph> <glyph class="state variable" id="_c7070768-ee66-4089-8304-f46d9c193446"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10924.75" y="1433.5"/> </glyph> <glyph class="state variable" id="_562463fa-ffe1-4186-ba74-b5565fb26ac8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10948.182" y="1433.5"/> </glyph> <glyph class="state variable" id="_bfbcb0e1-2a4d-4eda-95fa-04e6df91ac6b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10964.75" y="1433.5"/> </glyph> <glyph class="state variable" id="_2f624a97-e0c4-4364-af22-380821f30af0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10924.75" y="1453.5"/> </glyph> <glyph class="state variable" id="_6620cc41-d6cf-4c4c-8b6e-65903a4af471"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10981.318" y="1433.5"/> </glyph> <glyph class="state variable" id="_0a928926-b95c-4297-b9c1-e81928561426"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11004.75" y="1433.5"/> </glyph> <glyph class="state variable" id="_9e8f5449-1949-45dd-9ceb-4c3a0a780402"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11004.75" y="1445.2157"/> </glyph> <glyph class="state variable" id="_f736bcd8-48ab-46a2-8d26-fa00003221b2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11004.75" y="1453.5"/> </glyph> <glyph class="state variable" id="_8669499a-ddea-45d5-b28b-62ed9e22c2f5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10924.75" y="1433.5"/> </glyph> <glyph class="state variable" id="_046bfa82-b39e-43a6-82f9-dd584c29c9f6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10924.75" y="1445.2157"/> </glyph> <glyph class="state variable" id="_5bd3f82b-a4b8-4f0f-b086-e6980b12149e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10924.75" y="1461.7843"/> </glyph> <glyph class="state variable" id="_7426e023-911b-47ad-93b9-0c2244b5682e"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="10928.406" y="1473.5"/> </glyph> <glyph class="state variable" id="_0501426b-5d86-444c-bcfd-685c6877c735"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="10948.606" y="1473.5"/> </glyph> <glyph class="state variable" id="_fb48d95f-42a8-41f7-a5ab-da88855fc381"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10964.75" y="1473.5"/> </glyph> <glyph class="state variable" id="_97f3b934-d0f0-4768-aad0-ea2391e23be4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10948.182" y="1473.5"/> </glyph> <glyph class="state variable" id="_b684d943-0fbc-472d-a18f-33abebdf8302"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10924.75" y="1473.5"/> </glyph> <glyph class="state variable" id="_8b84f2b7-b4ae-4aa8-8182-5b95013e73cf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10924.75" y="1453.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s151_wnc1_wnc2_sa121"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: karyopherin (importin) beta 1 HUGO:KPNB1 HGNC:6400 ENTREZ:3837 UNIPROT:Q14974 GENECARDS:KPNB1 REACTOME:57343 KEGG:3837 ATLASONC:GC_KPNB1 WIKI:KPNB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="KPNB1"/> <bbox w="80.0" h="40.0" x="10843.5" y="1343.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s150_wnc1_wnc2_sa122"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tubulin, alpha 1a HUGO:TUBA1A HGNC:20766 ENTREZ:7846 UNIPROT:Q71U36 GENECARDS:TUBA1A REACTOME:191692 KEGG:7846 ATLASONC:GC_TUBA1A WIKI:TUBA1A SwissProt: Q71U36 tubulin, alpha 1b HUGO:TUBA1B HGNC:18809 ENTREZ:10376 UNIPROT:P68363 GENECARDS:TUBA1B REACTOME:191693 KEGG:10376 ATLASONC:GC_TUBA1B WIKI:TUBA1B SwissProt: P68363 tubulin, alpha 1c HUGO:TUBA1C HGNC:20768 ENTREZ:84790 UNIPROT:Q9BQE3 GENECARDS:TUBA1C REACTOME:65667 KEGG:84790 ATLASONC:GC_TUBA1C WIKI:TUBA1C SwissProt: Q9BQE3 tubulin, alpha 3c HUGO:TUBA3C HGNC:12408 ENTREZ:7278 UNIPROT:Q13748 GENECARDS:TUBA3C REACTOME:154750 KEGG:7278 WIKI:TUBA3C SwissProt: Q13748 tubulin, alpha 3d HUGO:TUBA3D HGNC:24071 ENTREZ:113457 UNIPROT:Q13748 GENECARDS:TUBA3D REACTOME:154750 KEGG:113457 WIKI:TUBA3D tubulin, alpha 3e HUGO:TUBA3E HGNC:20765 ENTREZ:112714 UNIPROT:Q6PEY2 GENECARDS:TUBA3E WIKI:TUBA3E SwissProt: Q6PEY2 tubulin, alpha 4a HUGO:TUBA4A HGNC:12407 ENTREZ:7277 UNIPROT:P68366 GENECARDS:TUBA4A REACTOME:191690 KEGG:7277 ATLASONC:GC_TUBA4A WIKI:TUBA4A SwissProt: P68366 tubulin, alpha 8 HUGO:TUBA8 HGNC:12410 ENTREZ:51807 UNIPROT:Q9NY65 GENECARDS:TUBA8 KEGG:51807 WIKI:TUBA8 SwissProt: Q9NY65 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Tubulin-α*"/> <bbox w="80.0" h="40.0" x="10845.5" y="1387.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s208_wnc1_wnc2_sa166"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transportin 1 "karyopherin (importin) beta 2", KPNB2 HUGO:TNPO1 HGNC:6401 ENTREZ:3842 UNIPROT:Q92973 GENECARDS:TNPO1 REACTOME:57345 KEGG:3842 ATLASONC:GC_TNPO1 WIKI:TNPO1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TNPO1"/> <bbox w="80.0" h="40.0" x="10845.5" y="1434.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s343_wnc1_wnc2_csa22" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Ca2+:Calmodulin*:NFAT*:PPP3CB:PPP3R* Identifiers_end References_begin: s_wnc2_re42:(MAP:survival) PMID:21115349 s_wnc2_re44(MAP:survival): Tubulin-alpha binds both NFAT and KPNB1 after dephosphorylation of NFAT. PMID:21278340 TNPO1 is a transport protein that helps in the import of proteins into the nucleus. Although it has been described with associated with NRON, it is most likely that it binds first to NFAT complex, making this complex ready for import, then NRON can bind to this complex to hinder the import of the complex PMID:21709260 References_end</body> </html> </notes> <label text="(Calcineurin/ Calmodulin/ Ca2+)"/> <bbox w="102.0" h="258.0" x="11101.5" y="918.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s129_wnc1_wnc2_sa82"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="11111.0" y="1078.0"/> <glyph class="state variable" id="_eff15e7e-402f-449f-8388-506373405ed6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11186.0" y="1101.2843"/> </glyph> <glyph class="state variable" id="_4044058f-d89c-49f2-9c61-1dff11eab7c8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11186.0" y="1113.0"/> </glyph> <glyph class="state variable" id="_c406ee7c-3e14-40fe-b3ae-a093d4f2231b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11162.568" y="1113.0"/> </glyph> <glyph class="state variable" id="_e45c559b-e478-4655-b2bb-40a3b75ca5b7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11106.0" y="1073.0"/> </glyph> <glyph class="state variable" id="_22e2ffd9-0b46-43e9-86f6-f2914392e334"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11129.432" y="1073.0"/> </glyph> <glyph class="state variable" id="_347ba270-4d28-47ac-a594-2a5fb3131baf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11146.0" y="1073.0"/> </glyph> <glyph class="state variable" id="_b838c65e-3bb4-49ed-a206-651ce04aa70e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11106.0" y="1093.0"/> </glyph> <glyph class="state variable" id="_2c54de18-5179-4343-846e-06cf0de9d646"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11162.568" y="1073.0"/> </glyph> <glyph class="state variable" id="_da8d2d5f-a215-42da-95ea-290ac6674cc3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11186.0" y="1073.0"/> </glyph> <glyph class="state variable" id="_11047c00-9343-4015-8e1d-9a2f88b065b7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11186.0" y="1084.7157"/> </glyph> <glyph class="state variable" id="_dcdaf6a6-b054-4edf-971c-a613d947eb55"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11186.0" y="1093.0"/> </glyph> <glyph class="state variable" id="_2738a8ba-7457-4080-95bd-bbe43bd4231d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11106.0" y="1073.0"/> </glyph> <glyph class="state variable" id="_e0487553-98c8-48ea-a88b-c87ea6e651b4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11106.0" y="1084.7157"/> </glyph> <glyph class="state variable" id="_befe0643-c8c8-4475-9798-dfd92636e815"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11106.0" y="1101.2843"/> </glyph> <glyph class="state variable" id="_e1b8ddbd-0506-4966-91eb-4830ff51ef6a"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="11109.656" y="1113.0"/> </glyph> <glyph class="state variable" id="_3734d9dd-9c1a-4da5-9dbd-06c589af6f3b"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="11129.856" y="1113.0"/> </glyph> <glyph class="state variable" id="_1cf4603c-2b04-445c-b5c4-36e1def0d6a7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11146.0" y="1113.0"/> </glyph> <glyph class="state variable" id="_5c5fc52d-4c7b-45e7-ba99-04a52a07e931"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11129.432" y="1113.0"/> </glyph> <glyph class="state variable" id="_056c2173-2ded-4b78-8300-202cd8396fcb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11106.0" y="1113.0"/> </glyph> <glyph class="state variable" id="_c1b7089d-7863-4c85-a093-4ae9c059f561"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11106.0" y="1093.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s130_wnc1_wnc2_sa97"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, catalytic subunit, beta isozyme CALNB, "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)" HUGO:PPP3CB HGNC:9315 ENTREZ:5532 UNIPROT:P16298 GENECARDS:PPP3CB REACTOME:403037 KEGG:5532 ATLASONC:GC_PPP3CB WIKI:PPP3CB Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3CB"/> <bbox w="80.0" h="40.0" x="11111.0" y="924.5"/> <glyph class="state variable" id="_927d92ba-f818-410a-b983-e70e801f32cc"> <state value="" variable="S197"/> <bbox w="30.0" h="10.0" x="11176.0" y="919.7148"/> </glyph> <glyph class="state variable" id="_dc739a96-854d-4fa5-a9c6-435ecaf27ab1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11106.0" y="919.5"/> </glyph> <glyph class="state variable" id="_51136ed0-2afa-45a5-844c-e611c5957929"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11106.0" y="939.5"/> </glyph> <glyph class="state variable" id="_8c58a260-edd5-4b3c-b79d-b1a4ebe34340"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11106.0" y="959.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s131_wnc1_wnc2_sa98"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, regulatory subunit B, alpha "protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform" HUGO:PPP3R1 HGNC:9317 ENTREZ:5534 UNIPROT:P63098 GENECARDS:PPP3R1 REACTOME:51292 KEGG:5534 ATLASONC:GC_PPP3R1 WIKI:PPP3R1 protein phosphatase 3, regulatory subunit B, beta HUGO:PPP3PR2 GENECARDS:PPP3PR2 WIKI:PPP3PR2 HUGO:PPP3R2 HGNC:9318 ENTREZ:5535 UNIPROT:Q96LZ3 GENECARDS:PPP3R2 KEGG:5535 ATLASONC:GC_PPP3R2 WIKI:PPP3R2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3R*"/> <bbox w="80.0" h="40.0" x="11111.0" y="967.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s132_wnc1_wnc2_sa99"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: calmodulin 1 (phosphorylase kinase, delta) CALML2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 2 (phosphorylase kinase, delta) HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 3 (phosphorylase kinase, delta) HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Calmodulin*"/> <bbox w="80.0" h="40.0" x="11111.0" y="1010.0"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc2_s133_wnc1_wnc2_sa100"> <label text="Ca2+"/> <bbox w="25.0" h="25.0" x="11138.75" y="1051.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc2_s344_wnc1_wnc2_csa21" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Ca2+:Calmodulin*:NFAT*:PPP3CB:PPP3R* Identifiers_end References_begin: s_wnc2_re42:(MAP:survival) PMID:21115349 References_end</body> </html> </notes> <label text="(Calcineurin/ Calmodulin/ Ca2+)"/> <bbox w="107.0" h="277.0" x="11099.0" y="571.0"/> <glyph class="macromolecule" id="wnc1_wnc2_s118_wnc1_wnc2_sa92"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, catalytic subunit, beta isozyme CALNB, "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)" HUGO:PPP3CB HGNC:9315 ENTREZ:5532 UNIPROT:P16298 GENECARDS:PPP3CB REACTOME:403037 KEGG:5532 ATLASONC:GC_PPP3CB WIKI:PPP3CB Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3CB"/> <bbox w="80.0" h="40.0" x="11108.5" y="577.5"/> <glyph class="state variable" id="_3084498e-f90c-43cf-a8ae-5c5c63eae763"> <state value="" variable="S197"/> <bbox w="30.0" h="10.0" x="11173.5" y="572.7148"/> </glyph> <glyph class="state variable" id="_a25096bf-92e7-4cf4-8467-40cf39b0e0b4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11103.5" y="572.5"/> </glyph> <glyph class="state variable" id="_a8ff2a2a-074e-4252-9d21-188a81cc87bb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11103.5" y="592.5"/> </glyph> <glyph class="state variable" id="_39e21327-f29c-4331-97f9-057fe7801ac8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11103.5" y="612.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s119_wnc1_wnc2_sa93"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, regulatory subunit B, alpha "protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform" HUGO:PPP3R1 HGNC:9317 ENTREZ:5534 UNIPROT:P63098 GENECARDS:PPP3R1 REACTOME:51292 KEGG:5534 ATLASONC:GC_PPP3R1 WIKI:PPP3R1 protein phosphatase 3, regulatory subunit B, beta HUGO:PPP3PR2 GENECARDS:PPP3PR2 WIKI:PPP3PR2 HUGO:PPP3R2 HGNC:9318 ENTREZ:5535 UNIPROT:Q96LZ3 GENECARDS:PPP3R2 KEGG:5535 ATLASONC:GC_PPP3R2 WIKI:PPP3R2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PPP3R*"/> <bbox w="80.0" h="40.0" x="11108.5" y="620.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s120_wnc1_wnc2_sa94"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: calmodulin 1 (phosphorylase kinase, delta) CALML2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 2 (phosphorylase kinase, delta) HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 3 (phosphorylase kinase, delta) HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Calmodulin*"/> <bbox w="80.0" h="40.0" x="11108.5" y="663.0"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc2_s121_wnc1_wnc2_sa95"> <label text="Ca2+"/> <bbox w="25.0" h="25.0" x="11136.25" y="704.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc2_s122_wnc1_wnc2_sa96"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="11110.0" y="744.0"/> <glyph class="state variable" id="_6b044101-26b1-48bb-9f29-e8b2ebf89587"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11182.5" y="767.2843"/> </glyph> <glyph class="state variable" id="_4057ddd8-9ca4-4f47-b74c-80ca8a9ee86f"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11182.5" y="779.0"/> </glyph> <glyph class="state variable" id="_e15e0964-26c0-45c3-9083-b5941f2e5760"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11159.068" y="779.0"/> </glyph> <glyph class="state variable" id="_ac54aa21-4424-458c-a503-b2cf9c62a427"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11102.5" y="739.0"/> </glyph> <glyph class="state variable" id="_1e9a77c6-48cd-4812-b2ea-21e322712b38"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11125.932" y="739.0"/> </glyph> <glyph class="state variable" id="_e27e395f-5d3f-482a-a1e7-edc1f204180c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11142.5" y="739.0"/> </glyph> <glyph class="state variable" id="_2286a9b1-b76d-4a32-a040-4d373dd35ee8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11105.0" y="759.0"/> </glyph> <glyph class="state variable" id="_7e6c8670-61b3-4334-bb86-f9427d246343"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11159.068" y="739.0"/> </glyph> <glyph class="state variable" id="_b4f910fb-9830-4c41-9dc3-9dcf90c2fd7d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11182.5" y="739.0"/> </glyph> <glyph class="state variable" id="_c7b21670-ca29-4a6b-bee3-97460b3e99fa"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11182.5" y="750.7157"/> </glyph> <glyph class="state variable" id="_192e27aa-8879-4478-a3bb-152e90144d6b"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11182.5" y="759.0"/> </glyph> <glyph class="state variable" id="_6d63681c-9b1c-4017-8951-e618fbea1f8d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11105.0" y="739.0"/> </glyph> <glyph class="state variable" id="_db933955-c627-49a6-b694-e75bccfd34be"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11105.0" y="750.7157"/> </glyph> <glyph class="state variable" id="_e4f1abdf-724d-4e30-bae1-f4d52bb7f442"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11105.0" y="767.2843"/> </glyph> <glyph class="state variable" id="_75efc04a-5ac9-4248-a1b2-18e7cda4e354"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="11108.656" y="779.0"/> </glyph> <glyph class="state variable" id="_c4bf456e-b662-493b-aeb6-afdb399a3dfa"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="11128.856" y="779.0"/> </glyph> <glyph class="state variable" id="_2c0c5818-957a-4c26-a96f-aed8ea10242b"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11142.5" y="779.0"/> </glyph> <glyph class="state variable" id="_73872dcf-892b-4da4-8391-429d327b0a84"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11125.932" y="779.0"/> </glyph> <glyph class="state variable" id="_d66e2fa4-a98f-47b3-bd1c-dac62d5dae07"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11102.5" y="779.0"/> </glyph> <glyph class="state variable" id="_d6346800-471c-4941-bc7f-918724de4f0c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11102.5" y="759.0"/> </glyph> </glyph> </glyph> <glyph class="source and sink" id="wnc1_s_wnc2_s272_wnc1_wnc2_sa216" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <label text="proteosome"/> <bbox w="30.0" h="30.0" x="10302.0" y="2043.0"/> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc2_s21_wnc1_wnc2_sa14"> <label text="Ca2+"/> <bbox w="25.0" h="25.0" x="10934.5" y="377.5"/> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc2_s74_wnc1_wnc2_sa59" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <label text="Ca2+"/> <bbox w="25.0" h="25.0" x="10707.5" y="680.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc2_s53_wnc1_wnc2_sa42" compartmentRef="wnc1_wnc2_c3_wnc1_wnc2_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: MOMP=mitochondrial outer membrane permeabilisation. PMID:20709625 s_wnc2_re17:(MAP:survival) PMID:21738214 References_end</body> </html> </notes> <label text="MOMP"/> <bbox w="80.0" h="30.0" x="10091.0" y="1340.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc2_s57_wnc1_wnc2_sa45" compartmentRef="wnc1_wnc2_c3_wnc1_wnc2_ca3"> <label text="Apoptosis"/> <bbox w="80.0" h="30.0" x="9941.0" y="1341.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc2_s58_wnc1_wnc2_sa46" compartmentRef="wnc1_wnc2_c3_wnc1_wnc2_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re17:(MAP:survival) PMID:21738214 References_end</body> </html> </notes> <label text="Necroptosis"/> <bbox w="80.0" h="30.0" x="9941.0" y="1410.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc2_s67_wnc1_wnc2_sa53" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <label text="EMT"/> <bbox w="80.0" h="30.0" x="10136.0" y="708.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc2_s85_wnc1_wnc2_sa66" compartmentRef="wnc1_wnc2_c3_wnc1_wnc2_ca3"> <label text="Survival"/> <bbox w="80.0" h="30.0" x="10360.0" y="1248.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc2_s92_wnc1_wnc2_sa72" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <label text="PI3K Akt MTOR pathway"/> <bbox w="80.0" h="30.0" x="10558.0" y="1376.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc2_s256_wnc1_wnc2_sa204" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <label text="MAPK pathway"/> <bbox w="80.0" h="30.0" x="10684.0" y="1445.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc2_s294_wnc1_wnc2_sa229" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <label text="WNT canonical pathway"/> <bbox w="80.0" h="30.0" x="10135.0" y="2542.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc2_s221_wnc1_wnc2_sa175" compartmentRef="wnc1_wnc2_c6_wnc1_wnc2_ca6"> <label text="TGF-β pathway"/> <bbox w="80.0" h="30.0" x="11941.0" y="760.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s1_wnc1_wnc2_sa4" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="9842.875" y="431.75"/> <glyph class="state variable" id="_4b456af0-19af-49f5-ac59-e07318ba396d"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="9825.375" y="451.71017"/> </glyph> <glyph class="state variable" id="_1a8a337a-05d5-4e0d-8257-f340f44f3a69"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="9865.407" y="426.75"/> </glyph> <glyph class="state variable" id="_c5bded26-cb27-414f-b4c7-478dfa3495e6"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="9905.375" y="427.01846"/> </glyph> <glyph class="state variable" id="_541960fd-2c06-4e3c-bd79-77367f44dfae"> <state value="" variable="S1496"/> <bbox w="35.0" h="10.0" x="9904.757" y="476.75"/> </glyph> <glyph class="state variable" id="_604f34ae-1d84-4d44-9524-0d767a05bf6d"> <state value="" variable="T1530"/> <bbox w="35.0" h="10.0" x="9864.4795" y="476.75"/> </glyph> <glyph class="state variable" id="_e049a3b8-6537-4385-9628-a44968c950cb"> <state value="" variable="S1533"/> <bbox w="35.0" h="10.0" x="9825.615" y="476.75"/> </glyph> <glyph class="unit of information" id="_f34561a8-af3f-41c7-b139-506172871a6e"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9860.375" y="426.75"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s2_wnc1_wnc2_sa3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Wnt5 (non-canonical) References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="9868.875" y="373.75"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s11_wnc1_wnc2_sa7" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="10053.0" y="538.0"/> <glyph class="state variable" id="_e099aa95-6ea5-48d6-ba87-6fc86abd9aa0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10128.0" y="533.0"/> </glyph> <glyph class="state variable" id="_c2aa2044-f9c4-4cee-a759-f405b3c9a3ab"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10048.0" y="533.0"/> </glyph> <glyph class="state variable" id="_ff0a2e50-bc5b-4d24-b952-de4b673e554d"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="10117.382" y="573.0"/> </glyph> <glyph class="state variable" id="_7aed72cf-afd9-4e99-a811-318511833220"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10048.0" y="533.0"/> </glyph> <glyph class="state variable" id="_ee479f27-2935-4c3a-9b75-d2b6ecc14e0a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10128.0" y="533.0"/> </glyph> <glyph class="state variable" id="_9798070b-4f6b-4469-9d1f-907591ad8727"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10127.634" y="533.0"/> </glyph> <glyph class="state variable" id="_1a8993cc-679d-46e1-a901-55a92697b048"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10128.0" y="573.0"/> </glyph> <glyph class="state variable" id="_64f7b7b8-249f-4ad4-a2e6-b0f48e4ff778"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="10038.0" y="572.7223"/> </glyph> <glyph class="state variable" id="_4408b4bc-0d10-47ea-a8cb-489e49fa1bf5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10048.0" y="573.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s16_wnc1_wnc2_sa9" compartmentRef="wnc1_wnc2_c5_wnc1_wnc2_ca5"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="64.0" h="90.0" x="11245.783" y="302.0"/> <glyph class="state variable" id="_0e3eb6df-b30c-4fef-8fd8-bccc63e4572e"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="11265.207" y="387.0"/> </glyph> <glyph class="state variable" id="_b4e28225-d2a4-482c-a0f9-f8a152b67559"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="11296.789" y="387.0"/> </glyph> <glyph class="state variable" id="_7fce84b4-f2b7-40b8-91e3-23655862d4b4"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="11297.283" y="297.48322"/> </glyph> <glyph class="state variable" id="_4eb361fa-df40-41b8-a658-a064fa019ae3"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="11265.309" y="297.0"/> </glyph> <glyph class="state variable" id="_4dabd78f-3ced-48af-b5cb-84a7291adc2a"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="11233.677" y="297.0"/> </glyph> <glyph class="state variable" id="_26a37d42-9661-42db-b3ee-ee23cb144fb7"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="11233.283" y="386.37518"/> </glyph> <glyph class="state variable" id="_0e164c71-c644-4923-949e-2f8c47e6f22d"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="11294.783" y="297.48322"/> </glyph> <glyph class="state variable" id="_3eed7771-e5b6-402d-b53e-fd0ed594e341"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="11294.783" y="297.48322"/> </glyph> <glyph class="state variable" id="_97be1e14-dad7-4408-9385-70b5d9300c74"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11240.783" y="342.0"/> </glyph> <glyph class="state variable" id="_93363282-d1aa-408f-a1c9-cc270bc89f9c"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="11231.177" y="297.0"/> </glyph> <glyph class="state variable" id="_efdc68bd-f152-4014-a316-2ff27ce666b1"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="11294.783" y="297.48322"/> </glyph> <glyph class="state variable" id="_614b38bd-b716-49e8-b92e-7f9bb7dd3187"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11240.783" y="323.36038"/> </glyph> <glyph class="state variable" id="_1f43cdc0-a561-4e9c-a2af-a4226259e89a"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="11294.783" y="297.48322"/> </glyph> <glyph class="state variable" id="_359632cc-7106-46a4-80bc-a6753e639408"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11240.783" y="342.0"/> </glyph> <glyph class="state variable" id="_e0e98a41-7ba7-4452-a2c1-77b29d0d6923"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="11294.289" y="387.0"/> </glyph> <glyph class="state variable" id="_3986f00d-25cd-4d01-8cb7-379d33604d79"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="11294.783" y="297.48322"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s17_wnc1_wnc2_sa10" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="64.0" h="90.0" x="11245.783" y="396.0"/> <glyph class="state variable" id="_7ed90f9e-807f-4e82-92e0-1e1962b047b0"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="11265.207" y="481.0"/> </glyph> <glyph class="state variable" id="_467df0fb-cdb1-49f3-aaef-96d0d7a189d4"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="11296.789" y="481.0"/> </glyph> <glyph class="state variable" id="_8851f4e7-d94b-452e-9645-c78c9a89339f"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="11297.283" y="391.48322"/> </glyph> <glyph class="state variable" id="_fd9ba0ac-2f68-49d0-bc0a-d526879bd0e6"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="11265.309" y="391.0"/> </glyph> <glyph class="state variable" id="_04d90372-baeb-4bda-ae26-aea25aea24d4"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="11233.677" y="391.0"/> </glyph> <glyph class="state variable" id="_36392b71-7385-4bf8-ae81-fb43a5ff90b9"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="11233.283" y="480.37518"/> </glyph> <glyph class="state variable" id="_15651e39-1120-4c70-8e8c-c88eaf81fdbb"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="11294.783" y="391.48322"/> </glyph> <glyph class="state variable" id="_54625443-dc3f-42a2-b5a3-a683f4703980"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="11294.783" y="391.48322"/> </glyph> <glyph class="state variable" id="_1789e53a-8b4e-4401-a22e-806e79e1ef87"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11240.783" y="436.0"/> </glyph> <glyph class="state variable" id="_51d95ac4-de64-4c2d-b71b-2d8de06a5ed9"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="11231.177" y="391.0"/> </glyph> <glyph class="state variable" id="_af0e11c5-9625-4aaa-aa9e-e05849583b6d"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="11294.783" y="391.48322"/> </glyph> <glyph class="state variable" id="_267a7129-00bd-429d-a8d2-fc3f18b8f9b4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11240.783" y="417.36038"/> </glyph> <glyph class="state variable" id="_d9a94520-c4c1-4749-a27e-4fdee98d9f88"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="11294.783" y="391.48322"/> </glyph> <glyph class="state variable" id="_61930ebe-6084-4da6-b193-1e32f014baf1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11240.783" y="436.0"/> </glyph> <glyph class="state variable" id="_91b2094b-2438-4140-b90f-2a926724eefd"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="11294.289" y="481.0"/> </glyph> <glyph class="state variable" id="_26213d23-4cad-4127-8e10-26ba7dd5b2fb"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="11294.783" y="391.48322"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s18_wnc1_wnc2_sa11" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re4(MAP:survival): PMID:21506126, PMID:21303971 Path to phosphorylation of b-catenin is not completely depicted here. For full paths see AKT-pathway Activated CaSR inhibits phosphorylation of b-catenin, exact mechanism unknown PMID:22094462 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="64.0" h="90.0" x="11245.783" y="571.0"/> <glyph class="state variable" id="_408dbc7d-bdc7-444e-94c2-a193bdec97aa"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="11265.207" y="656.0"/> </glyph> <glyph class="state variable" id="_783838bd-01d0-4201-abed-4b4748b51bd0"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="11296.789" y="656.0"/> </glyph> <glyph class="state variable" id="_9837e440-e9fd-47a9-828c-9dbd0a65c8d3"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="11297.283" y="566.4832"/> </glyph> <glyph class="state variable" id="_de18ac1f-c430-42a1-9e3c-64410b20d500"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="11265.309" y="566.0"/> </glyph> <glyph class="state variable" id="_89e4ccc4-cb94-4d78-8174-3026ce7cf06a"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="11233.677" y="566.0"/> </glyph> <glyph class="state variable" id="_1e119211-07ba-422d-adaf-0f2f5b06e13b"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="11233.283" y="655.3752"/> </glyph> <glyph class="state variable" id="_c4612670-a6d8-471e-9ca5-495386363131"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="11294.783" y="566.4832"/> </glyph> <glyph class="state variable" id="_42c52cf9-bad4-4420-a689-3a2681662c53"> <state value="P" variable="S552"/> <bbox w="35.0" h="10.0" x="11292.283" y="566.4832"/> </glyph> <glyph class="state variable" id="_995b847f-cbb2-4ece-b016-bde213a838a8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11240.783" y="611.0"/> </glyph> <glyph class="state variable" id="_70a97b24-7f7e-4831-b99f-3bb8d52cf328"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="11231.177" y="566.0"/> </glyph> <glyph class="state variable" id="_0a38dc91-3470-450d-9310-1a5f6e4528d5"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="11294.783" y="566.4832"/> </glyph> <glyph class="state variable" id="_d8dea933-f46d-49f1-a9c8-8ce9b3f04f68"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11240.783" y="592.3604"/> </glyph> <glyph class="state variable" id="_678f9c0a-1c54-413f-ae64-e2bc9a3ab994"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="11294.783" y="566.4832"/> </glyph> <glyph class="state variable" id="_9659fcca-7f39-409b-aaa2-6987289b8d51"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11240.783" y="611.0"/> </glyph> <glyph class="state variable" id="_050271ce-8719-4557-a1b0-28c0b9932699"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="11294.289" y="656.0"/> </glyph> <glyph class="state variable" id="_3ea4f0e1-176a-4667-9208-54a8411c789f"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="11294.783" y="566.4832"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s20_wnc1_wnc2_sa13" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: calcium-sensing receptor HHC, HHC1, "hypocalciuric hypercalcemia 1" HUGO:CASR HGNC:1514 ENTREZ:846 UNIPROT:P41180 GENECARDS:CASR REACTOME:51416 KEGG:846 ATLASONC:GC_CASR WIKI:CASR Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CASR"/> <bbox w="80.0" h="50.0" x="10912.0" y="434.0"/> <glyph class="unit of information" id="_e65c3a9e-2b28-4185-be63-2b0138b29b6b"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="10929.5" y="429.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s25_wnc1_wnc2_sa17" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="64.0" h="90.0" x="11245.783" y="727.0"/> <glyph class="state variable" id="_9bd73f1f-322f-4b1e-8eed-b12937dea72a"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="11265.207" y="812.0"/> </glyph> <glyph class="state variable" id="_bed0a66c-00bb-4c21-9bf2-bc478511b8f5"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="11296.789" y="812.0"/> </glyph> <glyph class="state variable" id="_36f92b96-05e5-4aaf-b58c-43a5d35e9fac"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="11297.283" y="722.4832"/> </glyph> <glyph class="state variable" id="_ff4b078d-12b0-4c99-980f-e398b69ebee7"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="11265.309" y="722.0"/> </glyph> <glyph class="state variable" id="_5acbd8a5-39f3-45cf-9f31-4cf14c1502a1"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="11233.677" y="722.0"/> </glyph> <glyph class="state variable" id="_f8d34a69-a842-42ab-8db0-53b992cf4cbd"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="11233.283" y="811.3752"/> </glyph> <glyph class="state variable" id="_02905ab3-fb06-4923-a1ed-e9b6882832d2"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="11294.783" y="722.4832"/> </glyph> <glyph class="state variable" id="_b8c8dece-3dfe-4768-9261-6a0f738b437d"> <state value="P" variable="S552"/> <bbox w="35.0" h="10.0" x="11292.283" y="722.4832"/> </glyph> <glyph class="state variable" id="_33f97c91-f38f-4743-9641-a17f2b1feec8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11240.783" y="767.0"/> </glyph> <glyph class="state variable" id="_0cebdf4a-45e7-4717-965d-b01ba1f0e5a8"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="11231.177" y="722.0"/> </glyph> <glyph class="state variable" id="_6aa984f0-633d-468c-a75c-9612d16f164f"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="11294.783" y="722.4832"/> </glyph> <glyph class="state variable" id="_56f64ddf-021b-4adf-8990-4bfe18a17dfb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11240.783" y="748.3604"/> </glyph> <glyph class="state variable" id="_dc7a10ab-bd24-468f-92b5-7ccb48f20aa0"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="11294.783" y="722.4832"/> </glyph> <glyph class="state variable" id="_f7e33a37-e308-4486-bc45-f5f4571b2209"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11240.783" y="767.0"/> </glyph> <glyph class="state variable" id="_ac4667bc-0899-4765-89ad-a932fe482d4b"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="11294.289" y="812.0"/> </glyph> <glyph class="state variable" id="_996be069-f728-47ef-a3a7-fb089fcd7ad9"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="11294.783" y="722.4832"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s42_wnc1_wnc2_sa32" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: calpain 1, (mu/I) large subunit HUGO:CAPN1 HGNC:1476 ENTREZ:823 UNIPROT:P07384 GENECARDS:CAPN1 KEGG:823 ATLASONC:GC_CAPN1 WIKI:CAPN1 calpain 2, (m/II) large subunit HUGO:CAPN2 HGNC:1479 ENTREZ:824 UNIPROT:P17655 GENECARDS:CAPN2 KEGG:824 ATLASONC:GC_CAPN2 WIKI:CAPN2 calpain 3, (p94) HUGO:CAPN3 HGNC:1480 ENTREZ:825 UNIPROT:P20807 GENECARDS:CAPN3 KEGG:825 ATLASONC:GC_CAPN3 WIKI:CAPN3 calpain 5 HUGO:CAPN5 HGNC:1482 ENTREZ:726 UNIPROT:O15484 GENECARDS:CAPN5 KEGG:726 ATLASONC:GC_CAPN5 WIKI:CAPN5 calpain 6 HUGO:CAPN6 HGNC:1483 ENTREZ:827 UNIPROT:Q9Y6Q1 GENECARDS:CAPN6 KEGG:827 ATLASONC:GC_CAPN6 WIKI:CAPN6 calpain 7 HUGO:CAPN7 HGNC:1484 ENTREZ:23473 UNIPROT:Q9Y6W3 GENECARDS:CAPN7 KEGG:23473 WIKI:CAPN7 calpain 8 HUGO:CAPN8 HGNC:1485 ENTREZ:388743 UNIPROT:A6NHC0 GENECARDS:CAPN8 KEGG:388743 WIKI:CAPN8 calpain 9 HUGO:CAPN9 HGNC:1486 ENTREZ:10753 UNIPROT:O14815 GENECARDS:CAPN9 KEGG:10753 ATLASONC:GC_CAPN9 WIKI:CAPN9 calpain 10 HUGO:CAPN10 HGNC:1477 ENTREZ:11132 UNIPROT:Q9HC96 GENECARDS:CAPN10 KEGG:11132 ATLASONC:GC_CAPN10 WIKI:CAPN10 calpain 11 HUGO:CAPN11 HGNC:1478 ENTREZ:11131 UNIPROT:Q9UMQ6 GENECARDS:CAPN11 KEGG:11131 WIKI:CAPN11 calpain 12 HUGO:CAPN12 HGNC:13249 ENTREZ:147968 UNIPROT:Q6ZSI9 GENECARDS:CAPN12 WIKI:CAPN12 calpain 13 HUGO:CAPN13 HGNC:16663 ENTREZ:92291 UNIPROT:Q6MZZ7 GENECARDS:CAPN13 WIKI:CAPN13 calpain 14 HUGO:CAPN14 HGNC:16664 ENTREZ:440854 UNIPROT:A8MX76 GENECARDS:CAPN14 WIKI:CAPN14 calpain 15 HUGO:SOLH HGNC:11182 ENTREZ:6650 UNIPROT:O75808 GENECARDS:SOLH KEGG:6650 WIKI:SOLH calpain, small subunit 1 HUGO:CAPNS1 HGNC:1481 ENTREZ:826 UNIPROT:P04632 GENECARDS:CAPNS1 KEGG:826 ATLASONC:GC_CAPNS1 WIKI:CAPNS1 calpain, small subunit 2 HUGO:CAPNS2 HGNC:16371 ENTREZ:84290 UNIPROT:Q96L46 GENECARDS:CAPNS2 WIKI:CAPNS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Calpain*"/> <bbox w="80.0" h="40.0" x="10202.0" y="628.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s43_wnc1_wnc2_sa33" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re11(MAP:survival): PMID:20514436 PMID:12114545 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: CABIN1 HUGO:CABIN1 HGNC:24187 ENTREZ:23523 UNIPROT:Q9Y6J0 GENECARDS:CABIN1 KEGG:23523 ATLASONC:GC_CABIN1 WIKI:CABIN1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20514436 References_end</body> </html> </notes> <label text="CAIN*"/> <bbox w="80.0" h="40.0" x="9895.0" y="598.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s49_wnc1_wnc2_sa37" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re11(MAP:survival): PMID:20514436 PMID:12114545 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: CABIN1 HUGO:CABIN1 HGNC:24187 ENTREZ:23523 UNIPROT:Q9Y6J0 GENECARDS:CABIN1 KEGG:23523 ATLASONC:GC_CABIN1 WIKI:CABIN1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CAINTRUNC*"/> <bbox w="80.0" h="40.0" x="9895.0" y="709.0"/> <glyph class="unit of information" id="_a6a518d5-b1e7-4d1b-837e-76c7cccdec2b"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="9910.0" y="704.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s50_wnc1_wnc2_sa38" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re12:(MAP:survival) PMID:21738214, PMID:20709625 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BH3 interacting domain death agonist HUGO:BID HGNC:1050 ENTREZ:637 UNIPROT:P55957 GENECARDS:BID REACTOME:50826 KEGG:637 ATLASONC:GC_BID WIKI:BID Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BID"/> <bbox w="80.0" h="40.0" x="10017.0" y="937.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s51_wnc1_wnc2_sa39" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re12:(MAP:survival) PMID:21738214, PMID:20709625 s_wnc2_re14:(MAP:survival) PMID:20008353, PMID:20709625, PMID:21738214 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BH3 interacting domain death agonist HUGO:BID HGNC:1050 ENTREZ:637 UNIPROT:P55957 GENECARDS:BID REACTOME:50826 KEGG:637 ATLASONC:GC_BID WIKI:BID Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BIDTRUNC*"/> <bbox w="80.0" h="40.0" x="10227.0" y="937.0"/> <glyph class="unit of information" id="_32f9dbc6-bcd0-46d4-ba4c-c4ba6611177c"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10242.0" y="932.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s52_wnc1_wnc2_sa40" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re22(MAP:survival): PMID:14681224, PMID:14612448 However, the mechanism in which truncated Bax increases apoptosis remains controversial. PMID:20008353 s_wnc2_re14:(MAP:survival) PMID:20008353, PMID:20709625, PMID:21738214 s_wnc2_re18:(MAP:survival) PMID:20709625, PMID:14612448, PMID:21414921 s_wnc2_re19:(MAP:survival) PMID:21486225 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 GENECARDS:BAX REACTOME:50715 KEGG:581 ATLASONC:BAXID128ch19q13 WIKI:BAX Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20709625 References_end Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 GENECARDS:BAX REACTOME:50715 KEGG:581 ATLASONC:BAXID128ch19q13 WIKI:BAX Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20709625 References_end</body> </html> </notes> <label text="BAX"/> <bbox w="80.0" h="40.0" x="10113.0" y="1034.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s59_wnc1_wnc2_sa47" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re18:(MAP:survival) PMID:20709625, PMID:14612448, PMID:21414921 s_wnc2_re22(MAP:survival): PMID:14681224, PMID:14612448 However, the mechanism in which truncated Bax increases apoptosis remains controversial. PMID:20008353 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated X protein HUGO:BAX HGNC:959 ENTREZ:581 UNIPROT:Q07812 GENECARDS:BAX REACTOME:50715 KEGG:581 ATLASONC:BAXID128ch19q13 WIKI:BAX Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BAXTRUNC*"/> <bbox w="80.0" h="40.0" x="9978.0" y="1034.0"/> <glyph class="unit of information" id="_a0ee20f3-f130-4204-9f67-1ec7ba9f1f21"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="9993.0" y="1029.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s60_wnc1_wnc2_sa48" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re19:(MAP:survival) PMID:21486225 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 1BCL2-associated agonist of cell death HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 GENECARDS:BCL2L1 REACTOME:50772 KEGG:598 ATLASONC:BCL2L1ID129ch20q11 WIKI:BCL2L1 BCL2-like 1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:10949026 PMID:18097445 References_end Identifiers_begin: BCL2-like 1BCL2-associated agonist of cell death HUGO:BCL2L1 HGNC:992 ENTREZ:598 UNIPROT:Q07817 GENECARDS:BCL2L1 REACTOME:50772 KEGG:598 ATLASONC:BCL2L1ID129ch20q11 WIKI:BCL2L1 BCL2-like 1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:10949026 PMID:18097445 References_end</body> </html> </notes> <label text="BCL2-XL*"/> <bbox w="80.0" h="40.0" x="10036.0" y="1091.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s68_wnc1_wnc2_sa54" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: protein kinase C alpha PKCA HUGO:PRKCA HGNC:9393 ENTREZ:5578 UNIPROT:P17252 protein kinase C beta PKCB PRKCB1 PRKCB2 "protein kinase C beta 1" HUGO:PRKCB HGNC:9395 ENTREZ:5579 UNIPROT:P05771 protein kinase C gamma PKCG SCA14 HUGO:PRKCG HGNC:9402 ENTREZ:5582 UNIPROT:P05129 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity. PMID:15567848 References_end Identifiers_begin: protein kinase C alpha PKCA HUGO:PRKCA HGNC:9393 ENTREZ:5578 UNIPROT:P17252 GENECARDS:PRKCA REACTOME:58197 KEGG:5578 ATLASONC:GC_PRKCA WIKI:PRKCA protein kinase C beta PKCB PRKCB1 PRKCB2 "protein kinase C beta 1" HUGO:PRKCB HGNC:9395 ENTREZ:5579 UNIPROT:P05771 GENECARDS:PRKCB REACTOME:58199 KEGG:5579 ATLASONC:GC_PRKCB WIKI:PRKCB protein kinase C gamma PKCG SCA14 HUGO:PRKCG HGNC:9402 ENTREZ:5582 UNIPROT:P05129 GENECARDS:PRKCG REACTOME:58205 KEGG:5582 ATLASONC:GC_PRKCG WIKI:PRKCG protein kinase C, delta HUGO:PRKCD HGNC:9399 ENTREZ:5580 UNIPROT:Q05655 GENECARDS:PRKCD REACTOME:58201 KEGG:5580 ATLASONC:PRKCDID42901ch3p21 WIKI:PRKCD protein kinase C, epsilon HUGO:PRKCE HGNC:9401 ENTREZ:5581 UNIPROT:Q02156 GENECARDS:PRKCE REACTOME:58203 KEGG:5581 ATLASONC:GC_PRKCE WIKI:PRKCE protein kinase C, eta HUGO:PRKCH HGNC:9403 ENTREZ:5583 UNIPROT:P24723 GENECARDS:PRKCH REACTOME:58209 KEGG:5583 ATLASONC:GC_PRKCH WIKI:PRKCH protein kinase C, iota HUGO:PRKCI HGNC:9404 ENTREZ:5584 UNIPROT:P41743 GENECARDS:PRKCI REACTOME:58207 KEGG:5584 ATLASONC:PRKCIID41857ch3q26 WIKI:PRKCI protein kinase C, theta HUGO:PRKCQ HGNC:9410 ENTREZ:5588 UNIPROT:Q04759 GENECARDS:PRKCQ REACTOME:58217 KEGG:5588 ATLASONC:GC_PRKCQ WIKI:PRKCQ Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity. PMID:15567848 PMID:11313945 PMID:11940581 Only PKC alpha and delta PMID:21386996 References_end</body> </html> Identifiers_begin: protein kinase C alpha PKCA HUGO:PRKCA HGNC:9393 ENTREZ:5578 UNIPROT:P17252 GENECARDS:PRKCA REACTOME:58197 KEGG:5578 ATLASONC:GC_PRKCA WIKI:PRKCA protein kinase C beta PKCB PRKCB1 PRKCB2 "protein kinase C beta 1" HUGO:PRKCB HGNC:9395 ENTREZ:5579 UNIPROT:P05771 GENECARDS:PRKCB REACTOME:58199 KEGG:5579 ATLASONC:GC_PRKCB WIKI:PRKCB protein kinase C gamma PKCG SCA14 HUGO:PRKCG HGNC:9402 ENTREZ:5582 UNIPROT:P05129 GENECARDS:PRKCG REACTOME:58205 KEGG:5582 ATLASONC:GC_PRKCG WIKI:PRKCG protein kinase C, delta HUGO:PRKCD HGNC:9399 ENTREZ:5580 UNIPROT:Q05655 GENECARDS:PRKCD REACTOME:58201 KEGG:5580 ATLASONC:PRKCDID42901ch3p21 WIKI:PRKCD protein kinase C, epsilon HUGO:PRKCE HGNC:9401 ENTREZ:5581 UNIPROT:Q02156 GENECARDS:PRKCE REACTOME:58203 KEGG:5581 ATLASONC:GC_PRKCE WIKI:PRKCE protein kinase C, eta HUGO:PRKCH HGNC:9403 ENTREZ:5583 UNIPROT:P24723 GENECARDS:PRKCH REACTOME:58209 KEGG:5583 ATLASONC:GC_PRKCH WIKI:PRKCH protein kinase C, iota HUGO:PRKCI HGNC:9404 ENTREZ:5584 UNIPROT:P41743 GENECARDS:PRKCI REACTOME:58207 KEGG:5584 ATLASONC:PRKCIID41857ch3q26 WIKI:PRKCI protein kinase C, theta HUGO:PRKCQ HGNC:9410 ENTREZ:5588 UNIPROT:Q04759 GENECARDS:PRKCQ REACTOME:58217 KEGG:5588 ATLASONC:GC_PRKCQ WIKI:PRKCQ Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity. PMID:15567848 PMID:11313945 PMID:11940581 Only PKC alpha and delta PMID:21386996 References_end</body> </html> </notes> <label text="PKC*"/> <bbox w="80.0" h="40.0" x="10680.0" y="528.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s69_wnc1_wnc2_sa55" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re24:(MAP:survival) PMID:10350048 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: calpastatin HUGO:CAST HGNC:1515 ENTREZ:831 UNIPROT:P20810 GENECARDS:CAST KEGG:10849 ATLASONC:GC_CAST WIKI:CAST Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Calpastatin*"/> <bbox w="80.0" h="40.0" x="10754.0" y="644.0"/> <glyph class="state variable" id="_825d98f5-e718-4516-ad8c-98be02ecc80f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10749.0" y="639.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s70_wnc1_wnc2_sa56" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re24:(MAP:survival) PMID:10350048 s_wnc2_re25(MAP:survival): Formation is dependent of Ca2+ concentration. It is believed that Ca2+ concentration regulates activity of Calpastatin. PMID:12684003 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: calpastatin HUGO:CAST HGNC:1515 ENTREZ:831 UNIPROT:P20810 GENECARDS:CAST KEGG:10849 ATLASONC:GC_CAST WIKI:CAST Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Calpastatin*"/> <bbox w="80.0" h="40.0" x="10606.5" y="644.0"/> <glyph class="state variable" id="_5fc89b46-e0e9-4d0f-a70b-23af35408632"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10599.0" y="639.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s89_wnc1_wnc2_sa69" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="10022.75" y="1638.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s90_wnc1_wnc2_sa70" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re30:(MAP:survival) PMID:22088220 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 References_end Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end</body> </html> </notes> <label text="BAD"/> <bbox w="80.0" h="40.0" x="10022.75" y="1555.0"/> <glyph class="state variable" id="_1d2ac1b3-66c4-42cf-b037-d29d529163a8"> <state value="" variable="S112"/> <bbox w="30.0" h="10.0" x="10008.242" y="1550.0"/> </glyph> <glyph class="state variable" id="_579b0a60-fc09-48d4-818c-f5876acab9cc"> <state value="" variable="S136"/> <bbox w="30.0" h="10.0" x="10087.75" y="1550.2147"/> </glyph> <glyph class="state variable" id="_6f83144f-f689-4097-a549-82d22f743ed6"> <state value="" variable="S155"/> <bbox w="30.0" h="10.0" x="10087.132" y="1590.0"/> </glyph> <glyph class="state variable" id="_2f92dd43-e477-49df-aacd-154a9cb40d0d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10017.75" y="1570.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s91_wnc1_wnc2_sa71" compartmentRef="wnc1_wnc2_c3_wnc1_wnc2_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re31:(MAP:survival) PMID:22088220 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 References_end Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end Identifiers_begin: BCL2-associated agonist of cell death HUGO:BAD HGNC:936 ENTREZ:572 UNIPROT:Q92934 GENECARDS:BAD REACTOME:50663 KEGG:572 ATLASONC:BADID130ch11q13 WIKI:BAD Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 PMID:10949026 PMID:19641503 References_end</body> </html> </notes> <label text="BAD"/> <bbox w="80.0" h="40.0" x="10022.75" y="1455.0"/> <glyph class="state variable" id="_14df0257-8f84-4bf0-8118-5f1738d4fec6"> <state value="" variable="S112"/> <bbox w="30.0" h="10.0" x="10008.242" y="1450.0"/> </glyph> <glyph class="state variable" id="_ed030b2b-a8d6-444d-b5ac-3f5c2168ff15"> <state value="" variable="S136"/> <bbox w="30.0" h="10.0" x="10087.75" y="1450.2147"/> </glyph> <glyph class="state variable" id="_a00d0446-382c-4daa-93fc-584a74d2339c"> <state value="" variable="S155"/> <bbox w="30.0" h="10.0" x="10087.132" y="1490.0"/> </glyph> <glyph class="state variable" id="_9b7cf592-9a61-4f97-9e72-c4f833b81a9a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10017.75" y="1470.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s93_wnc1_wnc2_sa73" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end</body> </html> </notes> <label text="FOXO1"/> <bbox w="80.0" h="40.0" x="10558.0" y="1199.0"/> <glyph class="state variable" id="_17fd31cc-447a-4ae3-98b6-533984d6c35c"> <state value="" variable="S329"/> <bbox w="30.0" h="10.0" x="10543.0" y="1233.7223"/> </glyph> <glyph class="state variable" id="_d70a99af-8456-4fed-89df-f4f62b295c34"> <state value="" variable="S319"/> <bbox w="30.0" h="10.0" x="10623.0" y="1194.0"/> </glyph> <glyph class="state variable" id="_73c8dc06-c064-4e97-909e-f55cea00f873"> <state value="" variable="S325"/> <bbox w="30.0" h="10.0" x="10582.904" y="1234.0"/> </glyph> <glyph class="state variable" id="_8755759d-5454-450a-b42a-1902516b29c2"> <state value="" variable="S322"/> <bbox w="30.0" h="10.0" x="10622.382" y="1234.0"/> </glyph> <glyph class="state variable" id="_2f98c71f-9c82-4b60-95cf-71a42c94061e"> <state value="" variable="S256"/> <bbox w="30.0" h="10.0" x="10583.032" y="1194.0"/> </glyph> <glyph class="state variable" id="_ee3e38fe-eb14-464f-be36-511395d6939d"> <state value="" variable="T24"/> <bbox w="25.0" h="10.0" x="10545.992" y="1194.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s94_wnc1_wnc2_sa74" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re35:(MAP:survival) PMID:17662023 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end Identifiers_begin: forkhead box O1 HUGO:FOXO1 HGNC:3819 ENTREZ:2308 UNIPROT:Q12778 GENECARDS:FOXO1 REACTOME:199304 KEGG:2308 ATLASONC:FOXO1ID83ch13q14 WIKI:FOXO1 FKHR, "forkhead homolog in rhabdomyosarcoma", FOXO1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15668399 References_end</body> </html> </notes> <label text="FOXO1"/> <bbox w="80.0" h="40.0" x="10558.0" y="1082.0"/> <glyph class="state variable" id="_8d471a7b-b385-4604-8d27-041803f0904e"> <state value="" variable="S329"/> <bbox w="30.0" h="10.0" x="10543.0" y="1116.7223"/> </glyph> <glyph class="state variable" id="_f90d8664-b0a7-4872-81e5-d42221cd6c41"> <state value="" variable="S319"/> <bbox w="30.0" h="10.0" x="10623.0" y="1077.0"/> </glyph> <glyph class="state variable" id="_4ab74da4-608b-44a5-90b6-4398f7f253a5"> <state value="" variable="S325"/> <bbox w="30.0" h="10.0" x="10582.904" y="1117.0"/> </glyph> <glyph class="state variable" id="_97b39f71-38bb-4d3b-a2b6-ef8ff10c41d4"> <state value="" variable="S322"/> <bbox w="30.0" h="10.0" x="10622.382" y="1117.0"/> </glyph> <glyph class="state variable" id="_7e5437b6-6948-47c6-9d70-6f15ca3fee36"> <state value="" variable="S256"/> <bbox w="30.0" h="10.0" x="10583.032" y="1077.0"/> </glyph> <glyph class="state variable" id="_d471aa95-b72e-48a5-9842-026bb99dddd8"> <state value="" variable="T24"/> <bbox w="25.0" h="10.0" x="10545.992" y="1077.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s103_wnc1_wnc2_sa81" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re59(MAP:survival): PMID:10788511, PMID:10094050, PMID:9585406 For a more detailed mechanism see CRM1 in map Nucleus_MTOR References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <clone/> <bbox w="80.0" h="40.0" x="10782.0" y="781.0"/> <glyph class="state variable" id="_976eade5-5802-4ec6-a8de-c52bd811099e"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10854.5" y="804.2843"/> </glyph> <glyph class="state variable" id="_785b0016-d6ce-453a-8cc6-20d3d51aee41"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10854.5" y="816.0"/> </glyph> <glyph class="state variable" id="_b2dbe4cf-c076-40f7-8e8f-3f35494040d5"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10831.068" y="816.0"/> </glyph> <glyph class="state variable" id="_5fb5935c-ea33-4837-9b6c-4916ebd1bd07"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10774.5" y="776.0"/> </glyph> <glyph class="state variable" id="_6f3476de-2d9b-4fe0-878a-b75ddee5756f"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10797.932" y="776.0"/> </glyph> <glyph class="state variable" id="_642b59eb-7ec4-441a-a489-1a12bd34ce0b"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10814.5" y="776.0"/> </glyph> <glyph class="state variable" id="_19ff2379-04c1-457c-a78a-ddc1bd6e4db9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10777.0" y="796.0"/> </glyph> <glyph class="state variable" id="_250707c3-d3cd-4725-8b04-e49bbe0e8a67"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10831.068" y="776.0"/> </glyph> <glyph class="state variable" id="_8e75d0a7-8ae9-4d6d-85eb-ad182a1eaa09"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10854.5" y="776.0"/> </glyph> <glyph class="state variable" id="_919563cd-5c29-46be-808d-708e4d5b9ae5"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10854.5" y="787.7157"/> </glyph> <glyph class="state variable" id="_9c768769-28de-453a-a050-33f8f284d9a8"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10854.5" y="796.0"/> </glyph> <glyph class="state variable" id="_23d2ddc2-7ad9-4cb8-8c97-119417b493c3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10777.0" y="776.0"/> </glyph> <glyph class="state variable" id="_c5373a21-6892-45c4-a597-aeb396c64c20"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10777.0" y="787.7157"/> </glyph> <glyph class="state variable" id="_73660b54-3525-4d11-a2bb-b40ccfe4ab30"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10777.0" y="804.2843"/> </glyph> <glyph class="state variable" id="_df42410d-c8aa-4fa1-bfbb-a1af60ef18bd"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="10780.656" y="816.0"/> </glyph> <glyph class="state variable" id="_8ea81e77-2538-4a83-aac5-6159ed6f4140"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="10800.856" y="816.0"/> </glyph> <glyph class="state variable" id="_48557f41-92ce-45a5-9b5c-e717b6f8847d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10814.5" y="816.0"/> </glyph> <glyph class="state variable" id="_ec716266-0e1d-4307-8122-f981afd82ccc"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10797.932" y="816.0"/> </glyph> <glyph class="state variable" id="_57410094-4468-4b4f-a63d-12287d1b7572"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10774.5" y="816.0"/> </glyph> <glyph class="state variable" id="_ae4ba1d6-be26-47cb-9185-df82d89742c5"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10774.5" y="796.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s103_wnc1_wnc2_sa199" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re59(MAP:survival): PMID:10788511, PMID:10094050, PMID:9585406 For a more detailed mechanism see CRM1 in map Nucleus_MTOR References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <clone/> <bbox w="80.0" h="40.0" x="11479.5" y="1569.0"/> <glyph class="state variable" id="_e82714ba-a7b9-4a2c-ab19-c1a606f65d39"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11552.0" y="1592.2843"/> </glyph> <glyph class="state variable" id="_404e4504-8d08-41f3-b874-c16982af3a87"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11552.0" y="1604.0"/> </glyph> <glyph class="state variable" id="_107cee86-0142-41d2-b37d-5f85456c75b8"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11528.568" y="1604.0"/> </glyph> <glyph class="state variable" id="_71181ae8-a2ff-4459-944e-574bb14f084c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11472.0" y="1564.0"/> </glyph> <glyph class="state variable" id="_30a70354-4d65-4bb0-aece-1e48dfd2661c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11495.432" y="1564.0"/> </glyph> <glyph class="state variable" id="_4459944f-3a5c-4b70-a104-4f1dfc9f84b5"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11512.0" y="1564.0"/> </glyph> <glyph class="state variable" id="_78af6cc5-1ec7-40e0-8286-3000c2604d37"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11474.5" y="1584.0"/> </glyph> <glyph class="state variable" id="_a770e903-9731-456e-8663-4baf0d25070c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11528.568" y="1564.0"/> </glyph> <glyph class="state variable" id="_c0d04aea-9781-49ca-b873-659739f4b7be"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11552.0" y="1564.0"/> </glyph> <glyph class="state variable" id="_26d54862-4099-426f-a4bb-a207f37a2e1e"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11552.0" y="1575.7157"/> </glyph> <glyph class="state variable" id="_33df1e67-48a4-497d-92fe-ca78f85dbf5c"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11552.0" y="1584.0"/> </glyph> <glyph class="state variable" id="_87aa102b-21f0-4e1f-b119-7e2cff95a9cf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11474.5" y="1564.0"/> </glyph> <glyph class="state variable" id="_c97a8023-399b-418c-a070-315087b2ccfc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11474.5" y="1575.7157"/> </glyph> <glyph class="state variable" id="_a8bd4867-4cca-4a28-9f06-0bd4ff3e29b6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11474.5" y="1592.2843"/> </glyph> <glyph class="state variable" id="_28058212-cd50-4464-9a52-4e9339283c40"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="11478.156" y="1604.0"/> </glyph> <glyph class="state variable" id="_025c55c3-758e-4a9b-81de-8dee97e8a9fe"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="11498.356" y="1604.0"/> </glyph> <glyph class="state variable" id="_cba22461-c07a-4389-ae0d-082da6e22ddb"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11512.0" y="1604.0"/> </glyph> <glyph class="state variable" id="_304b43ce-423b-437f-846e-ddf4398a14d6"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11495.432" y="1604.0"/> </glyph> <glyph class="state variable" id="_bf272893-57b4-4c1d-b4d1-2e1a4a6f7190"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11472.0" y="1604.0"/> </glyph> <glyph class="state variable" id="_d21c87d3-4f14-42df-9610-2f3917f6af8e"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11472.0" y="1584.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s136_wnc1_wnc2_sa110" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re44(MAP:survival): Tubulin-alpha binds both NFAT and KPNB1 after dephosphorylation of NFAT. PMID:21278340 TNPO1 is a transport protein that helps in the import of proteins into the nucleus. Although it has been described with associated with NRON, it is most likely that it binds first to NFAT complex, making this complex ready for import, then NRON can bind to this complex to hinder the import of the complex PMID:21709260 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: karyopherin (importin) beta 1 HUGO:KPNB1 HGNC:6400 ENTREZ:3837 UNIPROT:Q14974 GENECARDS:KPNB1 REACTOME:57343 KEGG:3837 ATLASONC:GC_KPNB1 WIKI:KPNB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="KPNB1"/> <bbox w="80.0" h="40.0" x="11035.5" y="1189.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s137_wnc1_wnc2_sa109" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re44(MAP:survival): Tubulin-alpha binds both NFAT and KPNB1 after dephosphorylation of NFAT. PMID:21278340 TNPO1 is a transport protein that helps in the import of proteins into the nucleus. Although it has been described with associated with NRON, it is most likely that it binds first to NFAT complex, making this complex ready for import, then NRON can bind to this complex to hinder the import of the complex PMID:21709260 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tubulin, alpha 1a HUGO:TUBA1A HGNC:20766 ENTREZ:7846 UNIPROT:Q71U36 GENECARDS:TUBA1A REACTOME:191692 KEGG:7846 ATLASONC:GC_TUBA1A WIKI:TUBA1A SwissProt: Q71U36 tubulin, alpha 1b HUGO:TUBA1B HGNC:18809 ENTREZ:10376 UNIPROT:P68363 GENECARDS:TUBA1B REACTOME:191693 KEGG:10376 ATLASONC:GC_TUBA1B WIKI:TUBA1B SwissProt: P68363 tubulin, alpha 1c HUGO:TUBA1C HGNC:20768 ENTREZ:84790 UNIPROT:Q9BQE3 GENECARDS:TUBA1C REACTOME:65667 KEGG:84790 ATLASONC:GC_TUBA1C WIKI:TUBA1C SwissProt: Q9BQE3 tubulin, alpha 3c HUGO:TUBA3C HGNC:12408 ENTREZ:7278 UNIPROT:Q13748 GENECARDS:TUBA3C REACTOME:154750 KEGG:7278 WIKI:TUBA3C SwissProt: Q13748 tubulin, alpha 3d HUGO:TUBA3D HGNC:24071 ENTREZ:113457 UNIPROT:Q13748 GENECARDS:TUBA3D REACTOME:154750 KEGG:113457 WIKI:TUBA3D tubulin, alpha 3e HUGO:TUBA3E HGNC:20765 ENTREZ:112714 UNIPROT:Q6PEY2 GENECARDS:TUBA3E WIKI:TUBA3E SwissProt: Q6PEY2 tubulin, alpha 4a HUGO:TUBA4A HGNC:12407 ENTREZ:7277 UNIPROT:P68366 GENECARDS:TUBA4A REACTOME:191690 KEGG:7277 ATLASONC:GC_TUBA4A WIKI:TUBA4A SwissProt: P68366 tubulin, alpha 8 HUGO:TUBA8 HGNC:12410 ENTREZ:51807 UNIPROT:Q9NY65 GENECARDS:TUBA8 KEGG:51807 WIKI:TUBA8 SwissProt: Q9NY65 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Tubulin-α*"/> <bbox w="80.0" h="40.0" x="11035.5" y="1231.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s166_wnc1_wnc2_sa139" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A HUGO:DYRK1A HGNC:3091 ENTREZ:1859 UNIPROT:Q13627 GENECARDS:DYRK1A REACTOME:54046 KEGG:1859 ATLASONC:DYRK1AID43234ch21q22 WIKI:DYRK1A 1859 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B HUGO:DYRK1B HGNC:3092 ENTREZ:9149 UNIPROT:Q9Y463 GENECARDS:DYRK1B KEGG:9149 ATLASONC:DYRK1BID43235ch19q13 WIKI:DYRK1B 9149 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 HUGO:DYRK2 HGNC:3093 ENTREZ:8445 UNIPROT:Q92630 GENECARDS:DYRK2 ATLASONC:GC_DYRK2 WIKI:DYRK2 8445 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 HUGO:DYRK3 HGNC:3094 ENTREZ:8444 UNIPROT:O43781 GENECARDS:DYRK3 KEGG:8444 ATLASONC:GC_DYRK3 WIKI:DYRK3 8444 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 HUGO:DYRK4 HGNC:3095 ENTREZ:8798 UNIPROT:Q9NR20 GENECARDS:DYRK4 ATLASONC:GC_DYRK4 WIKI:DYRK4 8798 DYRK, DYRK1, MNBH Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:9932450 PMID:19685005 References_end Identifiers_begin: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A HUGO:DYRK1A HGNC:3091 ENTREZ:1859 UNIPROT:Q13627 GENECARDS:DYRK1A REACTOME:54046 KEGG:1859 ATLASONC:DYRK1AID43234ch21q22 WIKI:DYRK1A 1859 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B HUGO:DYRK1B HGNC:3092 ENTREZ:9149 UNIPROT:Q9Y463 GENECARDS:DYRK1B KEGG:9149 ATLASONC:DYRK1BID43235ch19q13 WIKI:DYRK1B 9149 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 HUGO:DYRK2 HGNC:3093 ENTREZ:8445 UNIPROT:Q92630 GENECARDS:DYRK2 ATLASONC:GC_DYRK2 WIKI:DYRK2 8445 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 HUGO:DYRK3 HGNC:3094 ENTREZ:8444 UNIPROT:O43781 GENECARDS:DYRK3 KEGG:8444 ATLASONC:GC_DYRK3 WIKI:DYRK3 8444 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 HUGO:DYRK4 HGNC:3095 ENTREZ:8798 UNIPROT:Q9NR20 GENECARDS:DYRK4 ATLASONC:GC_DYRK4 WIKI:DYRK4 8798 DYRK, DYRK1, MNBH Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:9932450 PMID:19685005 References_end</body> </html> </notes> <label text="DYRK*"/> <bbox w="80.0" h="40.0" x="11483.625" y="766.5"/> <glyph class="state variable" id="_7194dd00-f6ab-4d9a-a83a-82f621c54e9f"> <state value="" variable="T308"/> <bbox w="30.0" h="10.0" x="11469.117" y="761.5"/> </glyph> <glyph class="state variable" id="_1cdb0759-6bb6-4345-b426-ff6a86a2bf5e"> <state value="" variable="T309"/> <bbox w="30.0" h="10.0" x="11508.657" y="761.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s167_wnc1_wnc2_sa140" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re46(MAP:survival): Upon Ca2+ activation the NRON-NFAT complex dissociates. PMID:21709260 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: IQ motif containing GTPase activating protein 1 HUGO:IQGAP1 HGNC:6110 ENTREZ:8826 UNIPROT:P46940 GENECARDS:IQGAP1 REACTOME:381664 KEGG:8826 ATLASONC:GC_IQGAP1 WIKI:IQGAP1 IQ motif containing GTPase activating protein 2 HUGO:IQGAP2 HGNC:6111 ENTREZ:10788 UNIPROT:Q13576 GENECARDS:IQGAP2 ATLASONC:GC_IQGAP2 WIKI:IQGAP2 IQ motif containing GTPase activating protein 3 HUGO:IQGAP3 HGNC:20669 ENTREZ:128239 UNIPROT:Q86VI3 GENECARDS:IQGAP3 WIKI:IQGAP3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="IQGAP*"/> <bbox w="80.0" h="40.0" x="11384.5" y="766.5"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s168_wnc1_wnc2_sa141" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="11790.0" y="766.5"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s169_wnc1_wnc2_sa142" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="11582.75" y="766.5"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s170_wnc1_wnc2_sa143" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re47(MAP:survival): LRKK2 mediates binding of NFAT to NRON and other components, but this is independent of its kinase activity and independent of the phosphorylation status of NFAT PMID:21983832 s_wnc2_re48:(MAP:survival) PMID:21709260 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: CSE1 chromosome segregation 1-like (yeast) "chromosome segregation 1 (yeast homolog)-like" HUGO:CSE1L HGNC:2431 ENTREZ:1434 UNIPROT:P55060 GENECARDS:CSE1L KEGG:1434 ATLASONC:CSE1LID40159ch20q13 WIKI:CSE1L Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CSE1L"/> <bbox w="80.0" h="40.0" x="11281.0" y="986.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s171_wnc1_wnc2_sa144" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re44(MAP:survival): Tubulin-alpha binds both NFAT and KPNB1 after dephosphorylation of NFAT. PMID:21278340 TNPO1 is a transport protein that helps in the import of proteins into the nucleus. Although it has been described with associated with NRON, it is most likely that it binds first to NFAT complex, making this complex ready for import, then NRON can bind to this complex to hinder the import of the complex PMID:21709260 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: transportin 1 "karyopherin (importin) beta 2", KPNB2 HUGO:TNPO1 HGNC:6401 ENTREZ:3842 UNIPROT:Q92973 GENECARDS:TNPO1 REACTOME:57345 KEGG:3842 ATLASONC:GC_TNPO1 WIKI:TNPO1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TNPO1"/> <bbox w="80.0" h="40.0" x="11281.0" y="1042.5"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s183_wnc1_wnc2_sa151" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re47(MAP:survival): LRKK2 mediates binding of NFAT to NRON and other components, but this is independent of its kinase activity and independent of the phosphorylation status of NFAT PMID:21983832 s_wnc2_re48:(MAP:survival) PMID:21709260 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: leucine-rich repeat kinase 2 HUGO:LRRK2 HGNC:18618 ENTREZ:120892 UNIPROT:Q5S007 GENECARDS:LRRK2 KEGG:120892 ATLASONC:GC_LRRK2 WIKI:LRRK2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LRRK2"/> <bbox w="80.0" h="40.0" x="11281.0" y="1099.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s211_wnc1_wnc2_sa200" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re61(MAP:survival): DYRK1A-mediated phosphorylation PMID:21965663 s_wnc2_re62:(MAP:survival) PMID:21965663, PMID:12063245 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: regulator of calcineurin 1 "Down syndrome critical region gene 1", DSCR1 HUGO:RCAN1 HGNC:3040 ENTREZ:1827 UNIPROT:P53805 GENECARDS:RCAN1 KEGG:1827 ATLASONC:GC_RCAN1 WIKI:RCAN1 regulator of calcineurin 2 HUGO:RCAN2 HGNC:3041 ENTREZ:10231 UNIPROT:Q14206 GENECARDS:RCAN2 KEGG:10231 ATLASONC:GC_RCAN2 WIKI:RCAN2 RCAN family member 3 "Down syndrome critical region gene 1-like 2", DSCR1L2 HUGO:RCAN3 HGNC:3042 ENTREZ:11123 UNIPROT:Q9UKA8 GENECARDS:RCAN3 KEGG:11123 ATLASONC:GC_RCAN3 WIKI:RCAN3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RCAN*"/> <bbox w="80.0" h="40.0" x="10529.0" y="1555.0"/> <glyph class="state variable" id="_761b04ad-e131-4e3c-a0c2-a9b127329106"> <state value="" variable="S94"/> <bbox w="25.0" h="10.0" x="10516.5" y="1550.0"/> </glyph> <glyph class="state variable" id="_f61e3192-7c26-455a-acfe-6c6f56a59f09"> <state value="" variable="S136"/> <bbox w="30.0" h="10.0" x="10594.0" y="1550.2147"/> </glyph> <glyph class="state variable" id="_5059cead-ec4f-49b0-bbac-6f73ae3e5a3e"> <state value="" variable="T192"/> <bbox w="30.0" h="10.0" x="10593.382" y="1590.0"/> </glyph> <glyph class="state variable" id="_a5865a39-ce53-4219-ba02-44bef2b3eb28"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10580.568" y="1550.0"/> </glyph> <glyph class="state variable" id="_6c915e3a-96e1-4fa1-b3ea-2f4942efc955"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10547.432" y="1550.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s227_wnc1_wnc2_sa183" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re54:(MAP:survival) PMID:18218901 s_wnc2_re55(MAP:survival): Homer1 binds only NFATc4/NFAT3, whereas NFATc3/NFAT4 does not bind to any Homer protein. PMID:18218901 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: homer homolog 3 (Drosophila) HUGO:HOMER3 HGNC:17514 ENTREZ:9454 UNIPROT:Q9NSC5 GENECARDS:HOMER3 KEGG:9454 WIKI:HOMER3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HOMER3"/> <bbox w="80.0" h="40.0" x="10016.0" y="1751.0"/> <glyph class="state variable" id="_b48cff1e-17b2-4ac1-8fa7-bb90cc081a11"> <state value="" variable="T36"/> <bbox w="25.0" h="10.0" x="10003.992" y="1746.0"/> </glyph> <glyph class="state variable" id="_aa77742b-b16c-4568-a5f9-e02e70830706"> <state value="" variable="S38"/> <bbox w="25.0" h="10.0" x="10043.532" y="1746.0"/> </glyph> <glyph class="state variable" id="_95dbd150-b356-4e1f-8893-a8e6bc66ed47"> <state value="" variable="S52"/> <bbox w="25.0" h="10.0" x="10083.5" y="1746.2147"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s229_wnc1_wnc2_sa184" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re54:(MAP:survival) PMID:18218901 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: homer homolog 3 (Drosophila) HUGO:HOMER3 HGNC:17514 ENTREZ:9454 UNIPROT:Q9NSC5 GENECARDS:HOMER3 KEGG:9454 WIKI:HOMER3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HOMER3"/> <bbox w="80.0" h="40.0" x="9884.5" y="1751.0"/> <glyph class="state variable" id="_c58a8bce-01bb-4f2a-bb83-db102beb595e"> <state value="P" variable="T36"/> <bbox w="30.0" h="10.0" x="9869.992" y="1746.0"/> </glyph> <glyph class="state variable" id="_56fe101a-f896-4807-959c-98ffcaf74969"> <state value="P" variable="S38"/> <bbox w="30.0" h="10.0" x="9909.532" y="1746.0"/> </glyph> <glyph class="state variable" id="_d0da7a11-3967-48ba-8198-a9692725feba"> <state value="P" variable="S52"/> <bbox w="30.0" h="10.0" x="9949.5" y="1746.2147"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s235_wnc1_wnc2_sa187" compartmentRef="wnc1_wnc2_c4_wnc1_wnc2_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="11083.0" y="2068.0"/> <glyph class="state variable" id="_c6d27dd0-1f58-48df-bc96-ebed0bad42d0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11158.0" y="2091.2842"/> </glyph> <glyph class="state variable" id="_9e3f02c0-5bf4-4c94-9c86-8d4c2784eb93"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11158.0" y="2103.0"/> </glyph> <glyph class="state variable" id="_fa0c4f21-0079-4f8f-ab28-d697396897ea"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11134.568" y="2103.0"/> </glyph> <glyph class="state variable" id="_05cfa046-6b46-49f4-a064-4f93fa2af787"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11078.0" y="2063.0"/> </glyph> <glyph class="state variable" id="_b0ca75e4-9e65-4a3c-bd0b-b1857d8a0b5a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11101.432" y="2063.0"/> </glyph> <glyph class="state variable" id="_ff51b611-dcc8-4202-bbad-bcc10fa43cba"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11118.0" y="2063.0"/> </glyph> <glyph class="state variable" id="_cfa120d3-dff9-42f3-ac3b-c30c5a20d29c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11078.0" y="2083.0"/> </glyph> <glyph class="state variable" id="_b6226578-0b17-4bf7-a050-05b4365a3561"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11134.568" y="2063.0"/> </glyph> <glyph class="state variable" id="_e3099e35-2e22-4dfd-9a75-b399dd2c48bf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11158.0" y="2063.0"/> </glyph> <glyph class="state variable" id="_908367f2-8698-46f2-90b3-8969c309e170"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11158.0" y="2074.7158"/> </glyph> <glyph class="state variable" id="_6a445795-ae59-4969-9232-7bbd318189a7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11158.0" y="2083.0"/> </glyph> <glyph class="state variable" id="_a388948e-69b5-4593-ad23-0ef8d3b49a32"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11078.0" y="2063.0"/> </glyph> <glyph class="state variable" id="_605fa2db-1797-481c-857e-b8226c117408"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11078.0" y="2074.7158"/> </glyph> <glyph class="state variable" id="_d683e90d-f467-46b4-b7be-749d7136b20f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11078.0" y="2091.2842"/> </glyph> <glyph class="state variable" id="_49f1e735-7573-41c2-8cfa-b578efe599ca"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="11081.656" y="2103.0"/> </glyph> <glyph class="state variable" id="_bcbe8a05-e949-4c93-814f-b3581f14ae49"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="11101.856" y="2103.0"/> </glyph> <glyph class="state variable" id="_3b1f6b6f-4ba5-485a-a6da-1b93bb8905bc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11118.0" y="2103.0"/> </glyph> <glyph class="state variable" id="_cba44354-7d43-46fd-a766-dfe256770a49"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11101.432" y="2103.0"/> </glyph> <glyph class="state variable" id="_4926d5ee-838e-4688-a291-d6afae5358d2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11078.0" y="2103.0"/> </glyph> <glyph class="state variable" id="_1bdc1a76-2eca-4d04-836f-f57632ad6501"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11078.0" y="2083.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s240_wnc1_wnc2_sa192" compartmentRef="wnc1_wnc2_c4_wnc1_wnc2_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: karyopherin (importin) beta 1 HUGO:KPNB1 HGNC:6400 ENTREZ:3837 UNIPROT:Q14974 GENECARDS:KPNB1 REACTOME:57343 KEGG:3837 ATLASONC:GC_KPNB1 WIKI:KPNB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="KPNB1"/> <bbox w="80.0" h="40.0" x="11463.75" y="1731.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s241_wnc1_wnc2_sa193" compartmentRef="wnc1_wnc2_c4_wnc1_wnc2_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: tubulin, alpha 1a HUGO:TUBA1A HGNC:20766 ENTREZ:7846 UNIPROT:Q71U36 GENECARDS:TUBA1A REACTOME:191692 KEGG:7846 ATLASONC:GC_TUBA1A WIKI:TUBA1A SwissProt: Q71U36 tubulin, alpha 1b HUGO:TUBA1B HGNC:18809 ENTREZ:10376 UNIPROT:P68363 GENECARDS:TUBA1B REACTOME:191693 KEGG:10376 ATLASONC:GC_TUBA1B WIKI:TUBA1B SwissProt: P68363 tubulin, alpha 1c HUGO:TUBA1C HGNC:20768 ENTREZ:84790 UNIPROT:Q9BQE3 GENECARDS:TUBA1C REACTOME:65667 KEGG:84790 ATLASONC:GC_TUBA1C WIKI:TUBA1C SwissProt: Q9BQE3 tubulin, alpha 3c HUGO:TUBA3C HGNC:12408 ENTREZ:7278 UNIPROT:Q13748 GENECARDS:TUBA3C REACTOME:154750 KEGG:7278 WIKI:TUBA3C SwissProt: Q13748 tubulin, alpha 3d HUGO:TUBA3D HGNC:24071 ENTREZ:113457 UNIPROT:Q13748 GENECARDS:TUBA3D REACTOME:154750 KEGG:113457 WIKI:TUBA3D tubulin, alpha 3e HUGO:TUBA3E HGNC:20765 ENTREZ:112714 UNIPROT:Q6PEY2 GENECARDS:TUBA3E WIKI:TUBA3E SwissProt: Q6PEY2 tubulin, alpha 4a HUGO:TUBA4A HGNC:12407 ENTREZ:7277 UNIPROT:P68366 GENECARDS:TUBA4A REACTOME:191690 KEGG:7277 ATLASONC:GC_TUBA4A WIKI:TUBA4A SwissProt: P68366 tubulin, alpha 8 HUGO:TUBA8 HGNC:12410 ENTREZ:51807 UNIPROT:Q9NY65 GENECARDS:TUBA8 KEGG:51807 WIKI:TUBA8 SwissProt: Q9NY65 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Tubulin-α*"/> <bbox w="80.0" h="40.0" x="11463.75" y="1773.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s242_wnc1_wnc2_sa195" compartmentRef="wnc1_wnc2_c4_wnc1_wnc2_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A HUGO:DYRK1A HGNC:3091 ENTREZ:1859 UNIPROT:Q13627 GENECARDS:DYRK1A REACTOME:54046 KEGG:1859 ATLASONC:DYRK1AID43234ch21q22 WIKI:DYRK1A DYRK, DYRK1, MNBH Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:11980723 PMID:19685005 Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase References_end Identifiers_begin: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A HUGO:DYRK1A HGNC:3091 ENTREZ:1859 UNIPROT:Q13627 GENECARDS:DYRK1A REACTOME:54046 KEGG:1859 ATLASONC:DYRK1AID43234ch21q22 WIKI:DYRK1A DYRK, DYRK1, MNBH Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:11980723 PMID:19685005 Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase References_end</body> </html> Identifiers_begin: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A HUGO:DYRK1A HGNC:3091 ENTREZ:1859 UNIPROT:Q13627 GENECARDS:DYRK1A REACTOME:54046 KEGG:1859 ATLASONC:DYRK1AID43234ch21q22 WIKI:DYRK1A DYRK, DYRK1, MNBH Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:11980723 PMID:19685005 Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase References_end</body> </html> </notes> <label text="DYRK1A"/> <bbox w="80.0" h="40.0" x="11168.0" y="2138.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s244_wnc1_wnc2_sa194" compartmentRef="wnc1_wnc2_c4_wnc1_wnc2_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re56(MAP:survival): DYRK1A/B primes NFAT in the nucleus, DYRK2 in the cytosol PMID:16511445 s_wnc2_re58:(MAP:survival) PMID:16511445, PMID:15121840 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="11253.5" y="2068.0"/> <glyph class="state variable" id="_beb0c0bb-715c-46d6-9648-c1b7a9fa7032"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11328.5" y="2091.2842"/> </glyph> <glyph class="state variable" id="_1f2e354b-c563-457a-a5e4-8c2cc4ed6a75"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11328.5" y="2103.0"/> </glyph> <glyph class="state variable" id="_4fa3d0ae-3a14-4e76-b808-047f124e1564"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11305.068" y="2103.0"/> </glyph> <glyph class="state variable" id="_3e8d76e1-f170-4ccd-9241-9db66bf60908"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11246.0" y="2063.0"/> </glyph> <glyph class="state variable" id="_c1548174-e8a0-4f29-9366-a8176b0cd1b9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11271.932" y="2063.0"/> </glyph> <glyph class="state variable" id="_bc602bc6-982b-40e6-a1a1-95fee8e6a3a3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11288.5" y="2063.0"/> </glyph> <glyph class="state variable" id="_596f727c-7ff4-4412-8e81-51be2c660e73"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11248.5" y="2083.0"/> </glyph> <glyph class="state variable" id="_724ce7df-1e4a-49d8-b135-f9197d98817e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11305.068" y="2063.0"/> </glyph> <glyph class="state variable" id="_640b987c-d056-43c1-b3b7-7eced6be9924"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11328.5" y="2063.0"/> </glyph> <glyph class="state variable" id="_d26d4369-72a0-446e-860c-a695db1b74b8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11328.5" y="2074.7158"/> </glyph> <glyph class="state variable" id="_7b449249-5e9b-404c-a8eb-b33228c15ac2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11328.5" y="2083.0"/> </glyph> <glyph class="state variable" id="_de768d1e-a63c-47d9-a0ab-eff305f44104"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11248.5" y="2063.0"/> </glyph> <glyph class="state variable" id="_3b0986f3-671c-4cfb-9ec5-6f69a2c7c0eb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11248.5" y="2074.7158"/> </glyph> <glyph class="state variable" id="_a557d4db-42cd-4ff1-8516-dba84145ba59"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11248.5" y="2091.2842"/> </glyph> <glyph class="state variable" id="_05b3a931-24e6-4c85-849f-f33a0600b363"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="11252.156" y="2103.0"/> </glyph> <glyph class="state variable" id="_8fe7a78f-3497-4a77-adf3-34c0d447de75"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="11272.356" y="2103.0"/> </glyph> <glyph class="state variable" id="_e62b6369-bb17-4609-be66-f7b63e6d0443"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11288.5" y="2103.0"/> </glyph> <glyph class="state variable" id="_4f322486-9b67-456f-8170-581535e6d223"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11269.432" y="2103.0"/> </glyph> <glyph class="state variable" id="_99488db3-9b9a-409d-a9f8-512e9e3496ab"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11248.5" y="2103.0"/> </glyph> <glyph class="state variable" id="_1b50116f-c8a3-4f07-81b4-2a1b6be7cd64"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11248.5" y="2083.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s245_wnc1_wnc2_sa196" compartmentRef="wnc1_wnc2_c4_wnc1_wnc2_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re58:(MAP:survival) PMID:16511445, PMID:15121840 s_wnc2_re59(MAP:survival): PMID:10788511, PMID:10094050, PMID:9585406 For a more detailed mechanism see CRM1 in map Nucleus_MTOR References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="11444.5" y="2068.0"/> <glyph class="state variable" id="_316722e6-cdc4-4239-82eb-7f8bb5aa1037"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11517.0" y="2091.2842"/> </glyph> <glyph class="state variable" id="_71f55191-a53a-4d24-bf63-e29f89add2ae"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11517.0" y="2103.0"/> </glyph> <glyph class="state variable" id="_0a9db3df-ee5b-4ea5-96a8-e763237547da"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11493.568" y="2103.0"/> </glyph> <glyph class="state variable" id="_f7d91c6a-a1c8-4ec4-ac76-7375fdac0225"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11437.0" y="2063.0"/> </glyph> <glyph class="state variable" id="_969b6c27-3fb5-4f03-857b-d2d2fbcae208"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11460.432" y="2063.0"/> </glyph> <glyph class="state variable" id="_2269f8ef-155f-4085-a394-e0bbf554d0dc"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11477.0" y="2063.0"/> </glyph> <glyph class="state variable" id="_add77428-e22d-494f-a90c-f3e2e35751f1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11439.5" y="2083.0"/> </glyph> <glyph class="state variable" id="_4a240cb0-4447-4501-969f-7c2015f55667"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11493.568" y="2063.0"/> </glyph> <glyph class="state variable" id="_3be18aeb-2f23-4cf7-afd4-7c68007bb2b2"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11517.0" y="2063.0"/> </glyph> <glyph class="state variable" id="_76158d88-5fda-4626-8324-eeb6dfa5af5b"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11517.0" y="2074.7158"/> </glyph> <glyph class="state variable" id="_b8564d89-9c15-4c4f-8813-6578ae6666e7"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11517.0" y="2083.0"/> </glyph> <glyph class="state variable" id="_7725d2ff-624f-46d6-bbe7-c6fcfd86e26c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11439.5" y="2063.0"/> </glyph> <glyph class="state variable" id="_185eec51-3034-4484-9739-5126ca5cf6c9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11439.5" y="2074.7158"/> </glyph> <glyph class="state variable" id="_9f488cfa-5d70-4650-8719-d9d2da8e82e8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11439.5" y="2091.2842"/> </glyph> <glyph class="state variable" id="_a21625d9-e2b1-487f-8433-79fb65a98e97"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="11443.156" y="2103.0"/> </glyph> <glyph class="state variable" id="_d6cbf6d1-c3e6-4a9e-b62f-3c89fff5bb2c"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="11463.356" y="2103.0"/> </glyph> <glyph class="state variable" id="_b07487a7-c294-4e21-893a-6d64598ae563"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11477.0" y="2103.0"/> </glyph> <glyph class="state variable" id="_94ee0b76-6b7e-4e55-83d8-03acc323eaaf"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11460.432" y="2103.0"/> </glyph> <glyph class="state variable" id="_e9f5f96b-7619-42ce-b9a4-712f13a1bf23"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11437.0" y="2103.0"/> </glyph> <glyph class="state variable" id="_27fa594f-ec6b-4640-930b-7778516e6706"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11437.0" y="2083.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s246_wnc1_wnc2_sa197" compartmentRef="wnc1_wnc2_c4_wnc1_wnc2_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re58:(MAP:survival) PMID:16511445, PMID:15121840 s_wnc4_re13:(MAP:survival) PMID:19131971 s_wnc4_re19:(MAP:survival) PMID:22745173 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="11347.0" y="1997.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s247_wnc1_wnc2_sa198" compartmentRef="wnc1_wnc2_c4_wnc1_wnc2_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end</body> </html> Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end</body> </html> Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end</body> </html> </notes> <label text="CK1*"/> <bbox w="80.0" h="40.0" x="11351.0" y="2147.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s249_wnc1_wnc2_sa168" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re61(MAP:survival): DYRK1A-mediated phosphorylation PMID:21965663 s_wnc2_re50:(MAP:survival) PMID:16131541 s_wnc2_re52:(MAP:survival) PMID:19136967 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: regulator of calcineurin 1 "Down syndrome critical region gene 1", DSCR1 HUGO:RCAN1 HGNC:3040 ENTREZ:1827 UNIPROT:P53805 GENECARDS:RCAN1 KEGG:1827 ATLASONC:GC_RCAN1 WIKI:RCAN1 regulator of calcineurin 2 HUGO:RCAN2 HGNC:3041 ENTREZ:10231 UNIPROT:Q14206 GENECARDS:RCAN2 KEGG:10231 ATLASONC:GC_RCAN2 WIKI:RCAN2 RCAN family member 3 "Down syndrome critical region gene 1-like 2", DSCR1L2 HUGO:RCAN3 HGNC:3042 ENTREZ:11123 UNIPROT:Q9UKA8 GENECARDS:RCAN3 KEGG:11123 ATLASONC:GC_RCAN3 WIKI:RCAN3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RCAN*"/> <bbox w="80.0" h="40.0" x="10675.0" y="472.0"/> <glyph class="state variable" id="_6e8515d4-17cd-41d2-a3bb-db4a0c9ab8ca"> <state value="" variable="S94"/> <bbox w="25.0" h="10.0" x="10662.5" y="467.0"/> </glyph> <glyph class="state variable" id="_8156f217-2a03-4062-95a7-d44b1c7e2c30"> <state value="" variable="S136"/> <bbox w="30.0" h="10.0" x="10740.0" y="467.21478"/> </glyph> <glyph class="state variable" id="_9fda305b-8ebb-4230-909a-bf7efec6e6ef"> <state value="P" variable="T192"/> <bbox w="35.0" h="10.0" x="10736.882" y="507.0"/> </glyph> <glyph class="state variable" id="_1ad9e1fa-e73f-4f13-8288-8af992ec0cc1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10726.568" y="467.0"/> </glyph> <glyph class="state variable" id="_a9c35f28-62dc-4c76-9ba8-10c1a7648d4c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10693.432" y="467.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s252_wnc1_wnc2_sa201" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re62:(MAP:survival) PMID:21965663, PMID:12063245 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: regulator of calcineurin 1 "Down syndrome critical region gene 1", DSCR1 HUGO:RCAN1 HGNC:3040 ENTREZ:1827 UNIPROT:P53805 GENECARDS:RCAN1 KEGG:1827 ATLASONC:GC_RCAN1 WIKI:RCAN1 regulator of calcineurin 2 HUGO:RCAN2 HGNC:3041 ENTREZ:10231 UNIPROT:Q14206 GENECARDS:RCAN2 KEGG:10231 ATLASONC:GC_RCAN2 WIKI:RCAN2 RCAN family member 3 "Down syndrome critical region gene 1-like 2", DSCR1L2 HUGO:RCAN3 HGNC:3042 ENTREZ:11123 UNIPROT:Q9UKA8 GENECARDS:RCAN3 KEGG:11123 ATLASONC:GC_RCAN3 WIKI:RCAN3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RCAN*"/> <bbox w="80.0" h="40.0" x="10529.0" y="1677.0"/> <glyph class="state variable" id="_a47b832f-fbef-4fb7-b149-312640d1cf6a"> <state value="" variable="S94"/> <bbox w="25.0" h="10.0" x="10516.5" y="1672.0"/> </glyph> <glyph class="state variable" id="_f0f168c4-3765-41ed-8d06-1f60ae9ad962"> <state value="" variable="S136"/> <bbox w="30.0" h="10.0" x="10594.0" y="1672.2147"/> </glyph> <glyph class="state variable" id="_efb82506-759e-4a5d-81eb-aaa259722c4f"> <state value="" variable="T192"/> <bbox w="30.0" h="10.0" x="10593.382" y="1712.0"/> </glyph> <glyph class="state variable" id="_5d13f9cb-ac63-4b33-b3ef-d16c716f94e6"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10578.068" y="1672.0"/> </glyph> <glyph class="state variable" id="_a4fca7c9-4e45-428f-a733-68e3dec8db37"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10547.432" y="1672.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s253_wnc1_wnc2_sa202" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1 REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 GENECARDS:MAPK3 KEGG:5595 ATLASONC:MAPK3ID425ch16p11 WIKI:MAPK3 mitogen-activated protein kinase 4 HUGO:MAPK4 HGNC:6878 ENTREZ:5596 UNIPROT:P31152 GENECARDS:MAPK4 KEGG:5596 ATLASONC:MAPK4ID41293ch18q21 WIKI:MAPK4 mitogen-activated protein kinase 6 HUGO:MAPK6 HGNC:6879 ENTREZ:5597 UNIPROT:Q16659 GENECARDS:MAPK6 KEGG:5597 ATLASONC:MAPK6ID43349ch15q21 WIKI:MAPK6 ERK, ERK2, MAPK2, p41mapk Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end</body> </html> </notes> <label text="ERK*"/> <bbox w="80.0" h="40.0" x="10683.0" y="1551.0"/> <glyph class="state variable" id="_7c0fc198-9af9-448b-8f93-c8ea4e2350ac"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10678.0" y="1572.9706"/> </glyph> <glyph class="state variable" id="_44a1b926-d501-4a6c-8e03-3a08d7464cf9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10678.0" y="1558.0802"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s255_wnc1_wnc2_sa203" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re43:(MAP:survival) PMID:19136967 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: regulator of calcineurin 1 "Down syndrome critical region gene 1", DSCR1 HUGO:RCAN1 HGNC:3040 ENTREZ:1827 UNIPROT:P53805 GENECARDS:RCAN1 KEGG:1827 ATLASONC:GC_RCAN1 WIKI:RCAN1 regulator of calcineurin 2 HUGO:RCAN2 HGNC:3041 ENTREZ:10231 UNIPROT:Q14206 GENECARDS:RCAN2 KEGG:10231 ATLASONC:GC_RCAN2 WIKI:RCAN2 RCAN family member 3 "Down syndrome critical region gene 1-like 2", DSCR1L2 HUGO:RCAN3 HGNC:3042 ENTREZ:11123 UNIPROT:Q9UKA8 GENECARDS:RCAN3 KEGG:11123 ATLASONC:GC_RCAN3 WIKI:RCAN3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RCAN*"/> <bbox w="80.0" h="40.0" x="10529.0" y="1772.0"/> <glyph class="state variable" id="_de04245a-f7cb-4f64-bcdb-45e2247df5ff"> <state value="" variable="S94"/> <bbox w="25.0" h="10.0" x="10516.5" y="1767.0"/> </glyph> <glyph class="state variable" id="_c348cc6f-31f5-4f20-a137-ed61be66df41"> <state value="" variable="S136"/> <bbox w="30.0" h="10.0" x="10594.0" y="1767.2147"/> </glyph> <glyph class="state variable" id="_892dbf17-85b0-4cfe-8cc9-ba52e6440d0e"> <state value="" variable="T192"/> <bbox w="30.0" h="10.0" x="10593.382" y="1807.0"/> </glyph> <glyph class="state variable" id="_df2c020f-54a7-4120-a7dd-6454cb7e4f8b"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10578.068" y="1767.0"/> </glyph> <glyph class="state variable" id="_c47c152f-602d-4b65-8eb3-3fb50f0c5a73"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10544.932" y="1767.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s258_wnc1_wnc2_sa206" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re66:(MAP:survival) PMID:11796223 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: myocyte enhancer factor 2A HUGO:MEF2A HGNC:6993 ENTREZ:4205 UNIPROT:Q02078 GENECARDS:MEF2A REACTOME:59133 KEGG:4205 ATLASONC:GC_MEF2A WIKI:MEF2A myocyte enhancer factor 2B HUGO:MEF2B HGNC:6995 ENTREZ:100271849 UNIPROT:Q02080 GENECARDS:MEF2B REACTOME:59135 KEGG:100271849 ATLASONC:GC_MEF2B WIKI:MEF2B myocyte enhancer factor 2C HUGO:MEF2C HGNC:6996 ENTREZ:4208 UNIPROT:Q06413 GENECARDS:MEF2C REACTOME:59137 KEGG:4208 ATLASONC:GC_MEF2C WIKI:MEF2C myocyte enhancer factor 2D HUGO:MEF2D HGNC:6997 ENTREZ:4209 UNIPROT:Q14814 GENECARDS:MEF2D REACTOME:59139 ATLASONC:MEF2DID43636ch1q22 WIKI:MEF2D Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MEF2*"/> <bbox w="80.0" h="40.0" x="10544.5" y="1948.0"/> <glyph class="state variable" id="_190877c1-839e-4e5e-9f1d-dec64c3ec4de"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10539.5" y="1943.0"/> </glyph> <glyph class="state variable" id="_9dd12f2b-6509-44a5-82dc-b12577a0cb00"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10579.5" y="1943.0"/> </glyph> <glyph class="state variable" id="_c6df4e04-7db9-443d-9c5f-bf382d32b182"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10619.5" y="1943.0"/> </glyph> <glyph class="state variable" id="_77a85745-61b8-4d25-a73b-8934aa0f70fb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10619.5" y="1983.0"/> </glyph> <glyph class="state variable" id="_a3217a35-23b7-4a4b-888e-8319323301a6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10579.5" y="1983.0"/> </glyph> <glyph class="state variable" id="_f337e336-742a-46bc-9bbd-b6e37c88ff08"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10539.5" y="1983.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s260_wnc1_wnc2_sa205" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re66:(MAP:survival) PMID:11796223 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: myocyte enhancer factor 2A HUGO:MEF2A HGNC:6993 ENTREZ:4205 UNIPROT:Q02078 GENECARDS:MEF2A REACTOME:59133 KEGG:4205 ATLASONC:GC_MEF2A WIKI:MEF2A myocyte enhancer factor 2B HUGO:MEF2B HGNC:6995 ENTREZ:100271849 UNIPROT:Q02080 GENECARDS:MEF2B REACTOME:59135 KEGG:100271849 ATLASONC:GC_MEF2B WIKI:MEF2B myocyte enhancer factor 2C HUGO:MEF2C HGNC:6996 ENTREZ:4208 UNIPROT:Q06413 GENECARDS:MEF2C REACTOME:59137 KEGG:4208 ATLASONC:GC_MEF2C WIKI:MEF2C myocyte enhancer factor 2D HUGO:MEF2D HGNC:6997 ENTREZ:4209 UNIPROT:Q14814 GENECARDS:MEF2D REACTOME:59139 ATLASONC:MEF2DID43636ch1q22 WIKI:MEF2D Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MEF2*"/> <bbox w="80.0" h="40.0" x="10387.0" y="1948.0"/> <glyph class="state variable" id="_88a6df23-9c76-4ea4-8bc9-ab255036f378"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10379.5" y="1943.0"/> </glyph> <glyph class="state variable" id="_ce05de36-2320-42b7-8571-7ab781d13a43"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10419.5" y="1943.0"/> </glyph> <glyph class="state variable" id="_bac95bfc-e369-46f2-a21b-0ac0dd4f6a4a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10459.5" y="1943.0"/> </glyph> <glyph class="state variable" id="_e0a6b2d2-662d-483b-ad9a-7b38d6e28cb6"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10459.5" y="1983.0"/> </glyph> <glyph class="state variable" id="_3926b1f0-9f55-4ce4-b44f-62d6fb7a4900"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10419.5" y="1983.0"/> </glyph> <glyph class="state variable" id="_ca23b40e-fb67-4d34-8ca5-1756d6f283df"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10379.5" y="1983.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s261_wnc1_wnc2_sa207" compartmentRef="wnc1_wnc2_c4_wnc1_wnc2_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re8:(MAP:survival) PMID:11796223 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: myocyte enhancer factor 2A HUGO:MEF2A HGNC:6993 ENTREZ:4205 UNIPROT:Q02078 GENECARDS:MEF2A REACTOME:59133 KEGG:4205 ATLASONC:GC_MEF2A WIKI:MEF2A myocyte enhancer factor 2B HUGO:MEF2B HGNC:6995 ENTREZ:100271849 UNIPROT:Q02080 GENECARDS:MEF2B REACTOME:59135 KEGG:100271849 ATLASONC:GC_MEF2B WIKI:MEF2B myocyte enhancer factor 2C HUGO:MEF2C HGNC:6996 ENTREZ:4208 UNIPROT:Q06413 GENECARDS:MEF2C REACTOME:59137 KEGG:4208 ATLASONC:GC_MEF2C WIKI:MEF2C myocyte enhancer factor 2D HUGO:MEF2D HGNC:6997 ENTREZ:4209 UNIPROT:Q14814 GENECARDS:MEF2D REACTOME:59139 ATLASONC:MEF2DID43636ch1q22 WIKI:MEF2D Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MEF2*"/> <bbox w="80.0" h="40.0" x="10756.5" y="1948.0"/> <glyph class="state variable" id="_b8e4ac85-e84b-44d7-9bf7-18ddcaeddc34"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10751.5" y="1943.0"/> </glyph> <glyph class="state variable" id="_0c5790e3-57dc-4133-ab6b-2cad9dbb2d5e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10791.5" y="1943.0"/> </glyph> <glyph class="state variable" id="_1699b9eb-fc1a-449b-9f55-9d7938f509e8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10831.5" y="1943.0"/> </glyph> <glyph class="state variable" id="_32e2834c-d93d-48e2-8d18-5bebfd360ef3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10831.5" y="1983.0"/> </glyph> <glyph class="state variable" id="_0d1520f1-0f6c-4164-9450-0c2ef30bd6b0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10791.5" y="1983.0"/> </glyph> <glyph class="state variable" id="_0547e3cf-7447-4dea-977e-bb178c841532"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10751.5" y="1983.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s262_wnc1_wnc2_sa208" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> </notes> <label text="E1*"/> <bbox w="80.0" h="40.0" x="9929.0" y="1872.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s263_wnc1_wnc2_sa209" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C ubiquitin-conjugating enzyme E2D 1 HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 ubiquitin-conjugating enzyme E2E 1 HUGO:UBE2E1 HGNC:12477 ENTREZ:7324 UNIPROT:P51965 GENECARDS:UBE2E1 REACTOME:66739 KEGG:7324 ATLASONC:GC_UBE2E1 WIKI:UBE2E1 ubiquitin-conjugating enzyme E2E 2 HUGO:UBE2E2 HGNC:12478 ENTREZ:7325 UNIPROT:Q96LR5 GENECARDS:UBE2E2 REACTOME:155471 KEGG:7325 ATLASONC:GC_UBE2E2 WIKI:UBE2E2 ubiquitin-conjugating enzyme E2G 1 HUGO:UBE2G1 HGNC:12482 ENTREZ:7326 UNIPROT:P62253 GENECARDS:UBE2G1 REACTOME:66753 KEGG:7326 ATLASONC:GC_UBE2G1 WIKI:UBE2G1 ubiquitin-conjugating enzyme E2G 2 HUGO:UBE2G2 HGNC:12483 ENTREZ:7327 UNIPROT:P60604 GENECARDS:UBE2G2 REACTOME:66773 KEGG:7327 ATLASONC:GC_UBE2G2 WIKI:UBE2G2 ubiquitin-conjugating enzyme E2H HUGO:UBE2H HGNC:12484 ENTREZ:7328 UNIPROT:P62256 GENECARDS:UBE2H REACTOME:66759 KEGG:7328 ATLASONC:GC_UBE2H WIKI:UBE2H ubiquitin-conjugating enzyme E2I HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I ubiquitin-conjugating enzyme E2 J1 HUGO:UBE2J1 HGNC:17598 ENTREZ:51465 UNIPROT:Q9Y385 GENECARDS:UBE2J1 REACTOME:155484 KEGG:51465 ATLASONC:GC_UBE2J1 WIKI:UBE2J1 ubiquitin-conjugating enzyme E2 J2 HUGO:UBE2J2 HGNC:19268 ENTREZ:118424 UNIPROT:Q8N2K1 GENECARDS:UBE2J2 REACTOME:155486 KEGG:118424 WIKI:UBE2J2 ubiquitin-conjugating enzyme E2K HUGO:UBE2K HGNC:4914 ENTREZ:3093 UNIPROT:P61086 GENECARDS:UBE2K REACTOME:66723 KEGG:3093 WIKI:UBE2K ubiquitin-conjugating enzyme E2L 3 HUGO:UBE2L3 HGNC:12488 ENTREZ:7332 UNIPROT:P68036 GENECARDS:UBE2L3 REACTOME:66741 KEGG:7332 ATLASONC:GC_UBE2L3 WIKI:UBE2L3 ubiquitin-conjugating enzyme E2L 4 HUGO:UBE2L4 HGNC:12489 ENTREZ:7333 GENECARDS:UBE2L4 WIKI:UBE2L4 ubiquitin-conjugating enzyme E2L 6 HUGO:UBE2L6 HGNC:12490 ENTREZ:9246 UNIPROT:O14933 GENECARDS:UBE2L6 REACTOME:66745 KEGG:9246 ATLASONC:GC_UBE2L6 WIKI:UBE2L6 ubiquitin-conjugating enzyme E2M HUGO:UBE2M HGNC:12491 ENTREZ:9040 UNIPROT:P61081 GENECARDS:UBE2M REACTOME:66777 KEGG:9040 ATLASONC:GC_UBE2M WIKI:UBE2M ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 GENECARDS:UBE2N REACTOME:66781 KEGG:7334 ATLASONC:GC_UBE2N WIKI:UBE2N ubiquitin-conjugating enzyme E2O HUGO:UBE2O HGNC:29554 ENTREZ:63893 UNIPROT:Q9C0C9 GENECARDS:UBE2O REACTOME:253534 KEGG:63893 ATLASONC:GC_UBE2O WIKI:UBE2O ubiquitin-conjugating enzyme E2Q family member 1 HUGO:UBE2Q1 HGNC:15698 ENTREZ:55585 UNIPROT:Q7Z7E8 GENECARDS:UBE2Q1 REACTOME:253474 KEGG:55585 ATLASONC:GC_UBE2Q1 WIKI:UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 2 HUGO:UBE2Q2 HGNC:19248 ENTREZ:92912 UNIPROT:Q8WVN8 GENECARDS:UBE2Q2 REACTOME:253479 ATLASONC:GC_UBE2Q2 WIKI:UBE2Q2 ubiquitin-conjugating enzyme E2R 2 HUGO:UBE2R2 HGNC:19907 ENTREZ:54926 UNIPROT:Q712K3 GENECARDS:UBE2R2 REACTOME:253483 KEGG:54926 ATLASONC:GC_UBE2R2 WIKI:UBE2R2 ubiquitin-conjugating enzyme E2S HUGO:UBE2S HGNC:17895 ENTREZ:27338 UNIPROT:Q16763 GENECARDS:UBE2S REACTOME:66751 KEGG:27338 ATLASONC:GC_UBE2S WIKI:UBE2S ubiquitin-conjugating enzyme E2Z HUGO:UBE2Z HGNC:25847 ENTREZ:65264 UNIPROT:Q9H832 GENECARDS:UBE2Z REACTOME:253545 KEGG:65264 WIKI:UBE2Z Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C ubiquitin-conjugating enzyme E2D 1 HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 ubiquitin-conjugating enzyme E2E 1 HUGO:UBE2E1 HGNC:12477 ENTREZ:7324 UNIPROT:P51965 GENECARDS:UBE2E1 REACTOME:66739 KEGG:7324 ATLASONC:GC_UBE2E1 WIKI:UBE2E1 ubiquitin-conjugating enzyme E2E 2 HUGO:UBE2E2 HGNC:12478 ENTREZ:7325 UNIPROT:Q96LR5 GENECARDS:UBE2E2 REACTOME:155471 KEGG:7325 ATLASONC:GC_UBE2E2 WIKI:UBE2E2 ubiquitin-conjugating enzyme E2G 1 HUGO:UBE2G1 HGNC:12482 ENTREZ:7326 UNIPROT:P62253 GENECARDS:UBE2G1 REACTOME:66753 KEGG:7326 ATLASONC:GC_UBE2G1 WIKI:UBE2G1 ubiquitin-conjugating enzyme E2G 2 HUGO:UBE2G2 HGNC:12483 ENTREZ:7327 UNIPROT:P60604 GENECARDS:UBE2G2 REACTOME:66773 KEGG:7327 ATLASONC:GC_UBE2G2 WIKI:UBE2G2 ubiquitin-conjugating enzyme E2H HUGO:UBE2H HGNC:12484 ENTREZ:7328 UNIPROT:P62256 GENECARDS:UBE2H REACTOME:66759 KEGG:7328 ATLASONC:GC_UBE2H WIKI:UBE2H ubiquitin-conjugating enzyme E2I HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I ubiquitin-conjugating enzyme E2 J1 HUGO:UBE2J1 HGNC:17598 ENTREZ:51465 UNIPROT:Q9Y385 GENECARDS:UBE2J1 REACTOME:155484 KEGG:51465 ATLASONC:GC_UBE2J1 WIKI:UBE2J1 ubiquitin-conjugating enzyme E2 J2 HUGO:UBE2J2 HGNC:19268 ENTREZ:118424 UNIPROT:Q8N2K1 GENECARDS:UBE2J2 REACTOME:155486 KEGG:118424 WIKI:UBE2J2 ubiquitin-conjugating enzyme E2K HUGO:UBE2K HGNC:4914 ENTREZ:3093 UNIPROT:P61086 GENECARDS:UBE2K REACTOME:66723 KEGG:3093 WIKI:UBE2K ubiquitin-conjugating enzyme E2L 3 HUGO:UBE2L3 HGNC:12488 ENTREZ:7332 UNIPROT:P68036 GENECARDS:UBE2L3 REACTOME:66741 KEGG:7332 ATLASONC:GC_UBE2L3 WIKI:UBE2L3 ubiquitin-conjugating enzyme E2L 4 HUGO:UBE2L4 HGNC:12489 ENTREZ:7333 GENECARDS:UBE2L4 WIKI:UBE2L4 ubiquitin-conjugating enzyme E2L 6 HUGO:UBE2L6 HGNC:12490 ENTREZ:9246 UNIPROT:O14933 GENECARDS:UBE2L6 REACTOME:66745 KEGG:9246 ATLASONC:GC_UBE2L6 WIKI:UBE2L6 ubiquitin-conjugating enzyme E2M HUGO:UBE2M HGNC:12491 ENTREZ:9040 UNIPROT:P61081 GENECARDS:UBE2M REACTOME:66777 KEGG:9040 ATLASONC:GC_UBE2M WIKI:UBE2M ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 GENECARDS:UBE2N REACTOME:66781 KEGG:7334 ATLASONC:GC_UBE2N WIKI:UBE2N ubiquitin-conjugating enzyme E2O HUGO:UBE2O HGNC:29554 ENTREZ:63893 UNIPROT:Q9C0C9 GENECARDS:UBE2O REACTOME:253534 KEGG:63893 ATLASONC:GC_UBE2O WIKI:UBE2O ubiquitin-conjugating enzyme E2Q family member 1 HUGO:UBE2Q1 HGNC:15698 ENTREZ:55585 UNIPROT:Q7Z7E8 GENECARDS:UBE2Q1 REACTOME:253474 KEGG:55585 ATLASONC:GC_UBE2Q1 WIKI:UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 2 HUGO:UBE2Q2 HGNC:19248 ENTREZ:92912 UNIPROT:Q8WVN8 GENECARDS:UBE2Q2 REACTOME:253479 ATLASONC:GC_UBE2Q2 WIKI:UBE2Q2 ubiquitin-conjugating enzyme E2R 2 HUGO:UBE2R2 HGNC:19907 ENTREZ:54926 UNIPROT:Q712K3 GENECARDS:UBE2R2 REACTOME:253483 KEGG:54926 ATLASONC:GC_UBE2R2 WIKI:UBE2R2 ubiquitin-conjugating enzyme E2S HUGO:UBE2S HGNC:17895 ENTREZ:27338 UNIPROT:Q16763 GENECARDS:UBE2S REACTOME:66751 KEGG:27338 ATLASONC:GC_UBE2S WIKI:UBE2S ubiquitin-conjugating enzyme E2Z HUGO:UBE2Z HGNC:25847 ENTREZ:65264 UNIPROT:Q9H832 GENECARDS:UBE2Z REACTOME:253545 KEGG:65264 WIKI:UBE2Z Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C ubiquitin-conjugating enzyme E2D 1 HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 ubiquitin-conjugating enzyme E2E 1 HUGO:UBE2E1 HGNC:12477 ENTREZ:7324 UNIPROT:P51965 GENECARDS:UBE2E1 REACTOME:66739 KEGG:7324 ATLASONC:GC_UBE2E1 WIKI:UBE2E1 ubiquitin-conjugating enzyme E2E 2 HUGO:UBE2E2 HGNC:12478 ENTREZ:7325 UNIPROT:Q96LR5 GENECARDS:UBE2E2 REACTOME:155471 KEGG:7325 ATLASONC:GC_UBE2E2 WIKI:UBE2E2 ubiquitin-conjugating enzyme E2G 1 HUGO:UBE2G1 HGNC:12482 ENTREZ:7326 UNIPROT:P62253 GENECARDS:UBE2G1 REACTOME:66753 KEGG:7326 ATLASONC:GC_UBE2G1 WIKI:UBE2G1 ubiquitin-conjugating enzyme E2G 2 HUGO:UBE2G2 HGNC:12483 ENTREZ:7327 UNIPROT:P60604 GENECARDS:UBE2G2 REACTOME:66773 KEGG:7327 ATLASONC:GC_UBE2G2 WIKI:UBE2G2 ubiquitin-conjugating enzyme E2H HUGO:UBE2H HGNC:12484 ENTREZ:7328 UNIPROT:P62256 GENECARDS:UBE2H REACTOME:66759 KEGG:7328 ATLASONC:GC_UBE2H WIKI:UBE2H ubiquitin-conjugating enzyme E2I HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I ubiquitin-conjugating enzyme E2 J1 HUGO:UBE2J1 HGNC:17598 ENTREZ:51465 UNIPROT:Q9Y385 GENECARDS:UBE2J1 REACTOME:155484 KEGG:51465 ATLASONC:GC_UBE2J1 WIKI:UBE2J1 ubiquitin-conjugating enzyme E2 J2 HUGO:UBE2J2 HGNC:19268 ENTREZ:118424 UNIPROT:Q8N2K1 GENECARDS:UBE2J2 REACTOME:155486 KEGG:118424 WIKI:UBE2J2 ubiquitin-conjugating enzyme E2K HUGO:UBE2K HGNC:4914 ENTREZ:3093 UNIPROT:P61086 GENECARDS:UBE2K REACTOME:66723 KEGG:3093 WIKI:UBE2K ubiquitin-conjugating enzyme E2L 3 HUGO:UBE2L3 HGNC:12488 ENTREZ:7332 UNIPROT:P68036 GENECARDS:UBE2L3 REACTOME:66741 KEGG:7332 ATLASONC:GC_UBE2L3 WIKI:UBE2L3 ubiquitin-conjugating enzyme E2L 4 HUGO:UBE2L4 HGNC:12489 ENTREZ:7333 GENECARDS:UBE2L4 WIKI:UBE2L4 ubiquitin-conjugating enzyme E2L 6 HUGO:UBE2L6 HGNC:12490 ENTREZ:9246 UNIPROT:O14933 GENECARDS:UBE2L6 REACTOME:66745 KEGG:9246 ATLASONC:GC_UBE2L6 WIKI:UBE2L6 ubiquitin-conjugating enzyme E2M HUGO:UBE2M HGNC:12491 ENTREZ:9040 UNIPROT:P61081 GENECARDS:UBE2M REACTOME:66777 KEGG:9040 ATLASONC:GC_UBE2M WIKI:UBE2M ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 GENECARDS:UBE2N REACTOME:66781 KEGG:7334 ATLASONC:GC_UBE2N WIKI:UBE2N ubiquitin-conjugating enzyme E2O HUGO:UBE2O HGNC:29554 ENTREZ:63893 UNIPROT:Q9C0C9 GENECARDS:UBE2O REACTOME:253534 KEGG:63893 ATLASONC:GC_UBE2O WIKI:UBE2O ubiquitin-conjugating enzyme E2Q family member 1 HUGO:UBE2Q1 HGNC:15698 ENTREZ:55585 UNIPROT:Q7Z7E8 GENECARDS:UBE2Q1 REACTOME:253474 KEGG:55585 ATLASONC:GC_UBE2Q1 WIKI:UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 2 HUGO:UBE2Q2 HGNC:19248 ENTREZ:92912 UNIPROT:Q8WVN8 GENECARDS:UBE2Q2 REACTOME:253479 ATLASONC:GC_UBE2Q2 WIKI:UBE2Q2 ubiquitin-conjugating enzyme E2R 2 HUGO:UBE2R2 HGNC:19907 ENTREZ:54926 UNIPROT:Q712K3 GENECARDS:UBE2R2 REACTOME:253483 KEGG:54926 ATLASONC:GC_UBE2R2 WIKI:UBE2R2 ubiquitin-conjugating enzyme E2S HUGO:UBE2S HGNC:17895 ENTREZ:27338 UNIPROT:Q16763 GENECARDS:UBE2S REACTOME:66751 KEGG:27338 ATLASONC:GC_UBE2S WIKI:UBE2S ubiquitin-conjugating enzyme E2Z HUGO:UBE2Z HGNC:25847 ENTREZ:65264 UNIPROT:Q9H832 GENECARDS:UBE2Z REACTOME:253545 KEGG:65264 WIKI:UBE2Z Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> </notes> <label text="E2*"/> <bbox w="80.0" h="40.0" x="9929.0" y="1923.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s273_wnc1_wnc2_sa217" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re70(MAP:survival): Only NFAT1 is sensitive to cleavage by caspase-3 at consensus sites: DELD and/or DVLD. PMID:16455648 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family; 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT1*"/> <bbox w="80.0" h="40.0" x="10657.0" y="1271.0"/> <glyph class="state variable" id="_9d25f3df-2bb5-4d96-80dd-81a2bebb6043"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10708.568" y="1306.0"/> </glyph> <glyph class="state variable" id="_b97760fb-dff6-4c7e-9616-5bc8780c517e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10692.0" y="1306.0"/> </glyph> <glyph class="state variable" id="_bfd41f11-d64c-4062-aa5a-eaca199af8ed"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10732.0" y="1266.0"/> </glyph> <glyph class="state variable" id="_0cfc2429-d1e6-45f8-b175-76ef093bae01"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10675.432" y="1306.0"/> </glyph> <glyph class="state variable" id="_e73d58e5-d0a4-47e8-a7a8-ee06affaea5a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10732.0" y="1277.7157"/> </glyph> <glyph class="state variable" id="_12fdb47b-6847-4e86-8032-2c2981210783"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10652.0" y="1306.0"/> </glyph> <glyph class="state variable" id="_72e6bbf3-a151-43bc-b963-cba17ea0bc26"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10692.0" y="1266.0"/> </glyph> <glyph class="state variable" id="_841b695b-752a-46ab-b1f4-2805fd9b32ba"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10652.0" y="1294.2843"/> </glyph> <glyph class="state variable" id="_cbf544a8-0e99-41bd-b649-6d027364ee85"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10708.568" y="1266.0"/> </glyph> <glyph class="state variable" id="_8188d14c-b833-4503-b043-120021eaf1a1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10652.0" y="1286.0"/> </glyph> <glyph class="state variable" id="_7e48f80f-b078-4ae2-840e-7f5bd1339957"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10652.0" y="1266.0"/> </glyph> <glyph class="state variable" id="_506e308e-7f20-424d-99d0-cc5c583aa5b7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10652.0" y="1277.7157"/> </glyph> <glyph class="state variable" id="_25979ca0-65aa-4697-90ea-640e6ec22431"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10675.432" y="1266.0"/> </glyph> <glyph class="state variable" id="_db9c0691-0abd-40c6-913c-9b897a1339d9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10732.0" y="1286.0"/> </glyph> <glyph class="state variable" id="_e248eb59-2eb1-418b-a04a-712b4dc86e30"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10732.0" y="1294.2843"/> </glyph> <glyph class="state variable" id="_a7292a51-3db0-4f94-b6b3-71ee8fad33fa"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10732.0" y="1306.0"/> </glyph> <glyph class="unit of information" id="_91b66e35-b496-4482-9719-dd7b1ec03de8"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10672.0" y="1266.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s274_wnc1_wnc2_sa218" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: caspase 3 apoptosis-related cysteine peptidase "caspase 3 apoptosis-related cysteine protease" HUGO:CASPASE3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: CASPASE3 cleaves KSR1 in apoptotic cells. Thus MEK is sequestered in the cytosol and its interaction with Raf and ERK is prevented. PMID:17613518 References_end Identifiers_begin: caspase 3 apoptosis-related cysteine peptidase "caspase 3 apoptosis-related cysteine protease" HUGO:CASPASE3 GENECARDS:CASPASE3 WIKI:CASPASE3 HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 GENECARDS:CASP3 REACTOME:57022 KEGG:836 ATLASONC:GC_CASP3 WIKI:CASP3 HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 GENECARDS:CASP3 REACTOME:57022 KEGG:836 ATLASONC:GC_CASP3 WIKI:CASP3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: CASPASE3 cleaves KSR1 in apoptotic cells. Thus MEK is sequestered in the cytosol and its interaction with Raf and ERK is prevented. PMID:17613518 References_end</body> </html> </notes> <label text="Caspase3TRUNC*"/> <bbox w="80.0" h="40.0" x="10772.0" y="1268.0"/> <glyph class="unit of information" id="_f65a4fdf-b4f9-468b-a41d-d63f87b87b79"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10787.0" y="1263.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s276_wnc1_wnc2_sa219" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re72(MAP:survival): Where exactly MDM2 ubiquitinates NFAT is not known and also not known if it is in the cytosol or nucleus. PMID:16307918 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="10406.5" y="2041.0"/> <glyph class="state variable" id="_d45c4d72-6aa3-46fe-b8f0-b80d42adddb2"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10479.0" y="2064.2842"/> </glyph> <glyph class="state variable" id="_cf7a9ee5-533d-43d1-8596-cef1489b0b59"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10479.0" y="2076.0"/> </glyph> <glyph class="state variable" id="_7b5490e1-561f-466c-86bb-6368779e9174"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10455.568" y="2076.0"/> </glyph> <glyph class="state variable" id="_9c493fc5-362f-4bd6-8d3d-eeacc5fe3fa2"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10399.0" y="2036.0"/> </glyph> <glyph class="state variable" id="_1efab9ca-fdb4-4555-b81c-b496561fbfc0"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10422.432" y="2036.0"/> </glyph> <glyph class="state variable" id="_ab9aeedd-1c3a-4b13-9c7a-9614c51cb6ff"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10439.0" y="2036.0"/> </glyph> <glyph class="state variable" id="_0bef2fc8-c77f-4489-bd06-fa6fe585da6c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10401.5" y="2056.0"/> </glyph> <glyph class="state variable" id="_b53ff6ec-3ded-4aa1-a633-be1a403e17dc"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10455.568" y="2036.0"/> </glyph> <glyph class="state variable" id="_79907c92-8062-45d7-8c92-9ee998e45d5b"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10479.0" y="2036.0"/> </glyph> <glyph class="state variable" id="_313c2de2-070d-451c-806f-f8f17cb4c973"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10479.0" y="2047.7157"/> </glyph> <glyph class="state variable" id="_f51f7402-a162-4190-99a3-4d20d9a45574"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10479.0" y="2056.0"/> </glyph> <glyph class="state variable" id="_8f397b5b-8229-4ed5-9aa6-a7b8b4ee3ce0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10401.5" y="2036.0"/> </glyph> <glyph class="state variable" id="_57877e0d-ba55-4421-bbb3-731450083fc6"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="10396.5" y="2047.7157"/> </glyph> <glyph class="state variable" id="_8a082ef6-a293-4980-b7e8-2626b23b1634"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="10396.5" y="2064.2842"/> </glyph> <glyph class="state variable" id="_f608427f-01c2-4ea4-b7f8-7a27c613921c"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="10405.156" y="2076.0"/> </glyph> <glyph class="state variable" id="_7f5ba07e-287a-4d7d-bd42-846164553315"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="10425.356" y="2076.0"/> </glyph> <glyph class="state variable" id="_889e9386-ffc0-4773-9ac3-d0eea047fd2a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10439.0" y="2076.0"/> </glyph> <glyph class="state variable" id="_115c875f-6bec-4746-b7fb-1b881d6e04ce"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10422.432" y="2076.0"/> </glyph> <glyph class="state variable" id="_3cda171f-3ed8-4f2f-ba33-a6705889b52e"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10399.0" y="2076.0"/> </glyph> <glyph class="state variable" id="_d949714f-3e71-433f-a904-1e36448c02f1"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10399.0" y="2056.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s277_wnc1_wnc2_sa220" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 References_end Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 GENECARDS:MDM2 REACTOME:95018 KEGG:4193 ATLASONC:MDM2ID115ch12q15 WIKI:MDM2 Mdm2 p53 binding protein homolog (mouse) Mdm2 p53 binding protein homo Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:CYCLINB MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 PMID:20679392 PMID:15169778 PMID:11923280 PMID:11715018 References_end</body> </html> Identifiers_begin: MDM2 oncogene E3 ubiquitin protein ligase "Mdm2 P53 binding protein homolog (mouse)" "Mdm2 P53 E3 ubiquitin protein ligase homolog (mouse)" "Mdm2 transformed 3T3 cell double minute 2 P53 binding protein (mouse)" "mouse double minute 2 human homolog of; P53-binding protein" HUGO:MDM2 HGNC:6973 ENTREZ:4193 UNIPROT:Q00987 GENECARDS:MDM2 REACTOME:95018 KEGG:4193 ATLASONC:MDM2ID115ch12q15 WIKI:MDM2 Mdm2 p53 binding protein homolog (mouse) Mdm2 p53 binding protein homo Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:CYCLINB MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. PMID:17158541 PMID:20679392 PMID:15169778 PMID:11923280 PMID:11715018 References_end</body> </html> </notes> <label text="MDM2"/> <bbox w="80.0" h="40.0" x="10251.0" y="1898.0"/> <glyph class="state variable" id="_11068ada-fabb-48fd-8ab7-484ec0ecdd96"> <state value="" variable="S166"/> <bbox w="30.0" h="10.0" x="10236.0" y="1893.9303"/> </glyph> <glyph class="state variable" id="_69158bf9-b008-4ddd-8e7f-772999e7aece"> <state value="" variable="S186"/> <bbox w="30.0" h="10.0" x="10316.0" y="1893.991"/> </glyph> <glyph class="state variable" id="_a4da683e-427c-4d66-8f26-ab6d893b3a80"> <state value="" variable="S188"/> <bbox w="30.0" h="10.0" x="10315.382" y="1933.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s278_wnc1_wnc2_sa221" compartmentRef="wnc1_wnc2_c4_wnc1_wnc2_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> </notes> <label text="CRM1*"/> <clone/> <bbox w="80.0" h="40.0" x="11586.0" y="1820.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s278_wnc1_wnc2_sa249" compartmentRef="wnc1_wnc2_c4_wnc1_wnc2_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> </notes> <label text="CRM1*"/> <clone/> <bbox w="80.0" h="40.0" x="10744.0" y="2007.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s19_wnc1_wnc2_sa12" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 GENECARDS:AKT2 REACTOME:49860 KEGG:208 ATLASONC:AKT2ID517ch19q13 WIKI:AKT2 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:CDH2 HGNC:1759 ENTREZ:1000 UNIPROT:P19022 GENECARDS:CDH2 REACTOME:51212 KEGG:1000 ATLASONC:GC_CDH2 WIKI:CDH2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end</body> </html> Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 GENECARDS:AKT2 REACTOME:49860 KEGG:208 ATLASONC:AKT2ID517ch19q13 WIKI:AKT2 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:CDH2 HGNC:1759 ENTREZ:1000 UNIPROT:P19022 GENECARDS:CDH2 REACTOME:51212 KEGG:1000 ATLASONC:GC_CDH2 WIKI:CDH2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end</body> </html> Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 GENECARDS:AKT2 REACTOME:49860 KEGG:208 ATLASONC:AKT2ID517ch19q13 WIKI:AKT2 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:CDH2 HGNC:1759 ENTREZ:1000 UNIPROT:P19022 GENECARDS:CDH2 REACTOME:51212 KEGG:1000 ATLASONC:GC_CDH2 WIKI:CDH2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end</body> </html> </notes> <label text="AKT*"/> <bbox w="80.0" h="40.0" x="11346.0" y="508.0"/> <glyph class="state variable" id="_78637d67-c523-4353-b36d-ed602ccf9cf1"> <state value="" variable="S129"/> <bbox w="30.0" h="10.0" x="11331.0" y="542.7223"/> </glyph> <glyph class="state variable" id="_d97eee02-1be9-4beb-923d-538a8a9381b8"> <state value="" variable="T450"/> <bbox w="30.0" h="10.0" x="11411.0" y="503.21478"/> </glyph> <glyph class="state variable" id="_8e3e4e10-d5a0-4fac-ac4b-d518c7b11bfc"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="11410.382" y="543.0"/> </glyph> <glyph class="state variable" id="_dee81be1-49be-4349-9566-47106090c876"> <state value="" variable="T308"/> <bbox w="30.0" h="10.0" x="11331.492" y="503.0"/> </glyph> <glyph class="state variable" id="_e01c3b45-5391-4fd4-babf-f992209b447e"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11418.5" y="503.0"/> </glyph> <glyph class="state variable" id="_91d5752c-33d1-477b-9684-9c354412d925"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11341.0" y="523.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s279_wnc1_wnc2_sa230" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ROR2"/> <bbox w="80.0" h="50.0" x="9785.0" y="1946.0"/> <glyph class="state variable" id="_46d20cc8-885b-415f-a527-c963fb484830"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9820.0" y="1991.0"/> </glyph> <glyph class="state variable" id="_4933b3e8-8125-4aca-b62a-a845e5842394"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9780.0" y="1941.0"/> </glyph> <glyph class="state variable" id="_c0a3b886-2b7c-49a0-af66-6f926e2cc856"> <state value="" variable="S864"/> <bbox w="30.0" h="10.0" x="9850.0" y="1941.2684"/> </glyph> <glyph class="state variable" id="_1c75b43b-2dc7-4799-8824-db29ac5265e3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9860.0" y="1991.0"/> </glyph> <glyph class="unit of information" id="_35c9d96e-a7f7-43b5-88ea-25ad5d36b6b4"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9802.5" y="1941.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s296_wnc1_wnc2_sa231"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Wnt1 and Wnt3 can bind to ROR2 PMID:18762249, PMID:14960582 Both Wnt ligands can reduce b-catenin/TCF/LEF transcription via NLK PMID:18762249, PMID:20194509 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family, member 3 INT4 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="WNT3"/> <bbox w="40.0" h="25.0" x="9731.0" y="1896.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s300_wnc1_wnc2_sa233" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="9785.0" y="1870.0"/> <glyph class="unit of information" id="_5e1d6c7f-ecb0-4207-a9b8-dca660bfc539"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9802.5" y="1865.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s307_wnc1_wnc2_sa239" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re77:(MAP:survival) PMID:16648474 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase kinase kinase 5 MEKK5 HUGO:MAP3K5 HGNC:6857 ENTREZ:4217 UNIPROT:Q99683 GENECARDS:MAP3K5 KEGG:4217 ATLASONC:GC_MAP3K5 WIKI:MAP3K5 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ASK1*"/> <bbox w="80.0" h="40.0" x="9890.0" y="992.0"/> <glyph class="state variable" id="_5dc5b676-5e2f-4571-ab8f-7339ac86ca83"> <state value="" variable="S967"/> <bbox w="30.0" h="10.0" x="9880.674" y="987.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s308_wnc1_wnc2_sa238" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re77:(MAP:survival) PMID:16648474 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase kinase kinase 5 MEKK5 HUGO:MAP3K5 HGNC:6857 ENTREZ:4217 UNIPROT:Q99683 GENECARDS:MAP3K5 KEGG:4217 ATLASONC:GC_MAP3K5 WIKI:MAP3K5 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ASK1*"/> <bbox w="80.0" h="40.0" x="9890.0" y="1084.0"/> <glyph class="state variable" id="_03868534-b5e0-4c55-8bea-7d7c7eec0c4a"> <state value="P" variable="S967"/> <bbox w="35.0" h="10.0" x="9878.174" y="1079.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s309_wnc1_wnc2_sa240" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: mitogen-activated protein kinase 11 PRKM11 HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 mitogen-activated protein kinase 12 SAPK3 HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 mitogen-activated protein kinase 13 PRKM13 HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 mitogen-activated protein kinase 14 CSBP1 CSBP2 CSPB1 HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: mitogen-activated protein kinase 11 PRKM11 HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 GENECARDS:MAPK11 REACTOME:59299 KEGG:5600 ATLASONC:GC_MAPK11 WIKI:MAPK11 mitogen-activated protein kinase 12 SAPK3 HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 GENECARDS:MAPK12 REACTOME:69723 KEGG:6300 ATLASONC:MAPK12ID41290ch22q13 WIKI:MAPK12 mitogen-activated protein kinase 13 PRKM13 HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 GENECARDS:MAPK13 REACTOME:59303 KEGG:5603 ATLASONC:MAPK13ID41291ch6p21 WIKI:MAPK13 mitogen-activated protein kinase 14 CSBP1 CSBP2 CSPB1 HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 GENECARDS:MAPK14 REACTOME:405912 KEGG:1432 ATLASONC:MAPK14ID41292ch6p21 WIKI:MAPK14 Mxi2 P38 "P38 MAP kinase" PRKM14 PRKM15 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> Identifiers_begin: mitogen-activated protein kinase 11 PRKM11 HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 GENECARDS:MAPK11 REACTOME:59299 KEGG:5600 ATLASONC:GC_MAPK11 WIKI:MAPK11 mitogen-activated protein kinase 12 SAPK3 HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 GENECARDS:MAPK12 REACTOME:69723 KEGG:6300 ATLASONC:MAPK12ID41290ch22q13 WIKI:MAPK12 mitogen-activated protein kinase 13 PRKM13 HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 GENECARDS:MAPK13 REACTOME:59303 KEGG:5603 ATLASONC:MAPK13ID41291ch6p21 WIKI:MAPK13 mitogen-activated protein kinase 14 CSBP1 CSBP2 CSPB1 HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 GENECARDS:MAPK14 REACTOME:405912 KEGG:1432 ATLASONC:MAPK14ID41292ch6p21 WIKI:MAPK14 Mxi2 P38 "P38 MAP kinase" PRKM14 PRKM15 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="p38*"/> <bbox w="80.0" h="40.0" x="9851.0" y="895.0"/> <glyph class="state variable" id="_a8fb4d01-b60c-4d8d-9df6-ee6aa1862cc7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9846.0" y="917.411"/> </glyph> <glyph class="state variable" id="_62fbbb2b-8781-46f0-8ca9-2e71b445164f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9846.0" y="902.68164"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s310_wnc1_wnc2_sa241" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: mitogen-activated protein kinase 8 PRKM8 HUGO:MAPK8 HGNC:6881 ENTREZ:5599 UNIPROT:P45983 mitogen-activated protein kinase 9 PRKM9 HUGO:MAPK9 HGNC:6886 ENTREZ:5601 UNIPROT:P45984 mitogen-activated protein kinase 10 PRKM10 HUGO:MAPK10 HGNC:6872 ENTREZ:5602 UNIPROT:P53779 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: mitogen-activated protein kinase 8 PRKM8 HUGO:MAPK8 HGNC:6881 ENTREZ:5599 UNIPROT:P45983 GENECARDS:MAPK8 REACTOME:59293 KEGG:5599 ATLASONC:JNK1ID196 WIKI:MAPK8 mitogen-activated protein kinase 9 PRKM9 HUGO:MAPK9 HGNC:6886 ENTREZ:5601 UNIPROT:P45984 GENECARDS:MAPK9 REACTOME:59295 KEGG:5601 ATLASONC:JNK2ID426 WIKI:MAPK9 mitogen-activated protein kinase 10 PRKM10 HUGO:MAPK10 HGNC:6872 ENTREZ:5602 UNIPROT:P53779 GENECARDS:MAPK10 REACTOME:59297 KEGG:5602 ATLASONC:JNK3ID427 WIKI:MAPK10 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="JNK*"/> <bbox w="80.0" h="40.0" x="9957.0" y="895.0"/> <glyph class="state variable" id="_f0911e31-f7e7-43ad-87b6-83e9995e950e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9952.0" y="917.6038"/> </glyph> <glyph class="state variable" id="_1dfc7809-c490-496c-af0e-0305def76e49"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9952.0" y="902.3962"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s314_wnc1_wnc2_sa242" compartmentRef="wnc1_wnc2_c4_wnc1_wnc2_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re85(MAP:survival): S272 and S89 are PKA sites in NFAT3 PMID:10611249 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="10939.0" y="2068.0"/> <glyph class="state variable" id="_cf6ff008-f203-48f6-a49e-2d00cae00469"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11014.0" y="2091.2842"/> </glyph> <glyph class="state variable" id="_c8702dc7-4faf-4e10-aa28-9168c8cbbdb0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11014.0" y="2103.0"/> </glyph> <glyph class="state variable" id="_581f9cde-c5d1-4765-9d63-953fcd3a277d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10990.568" y="2103.0"/> </glyph> <glyph class="state variable" id="_860c810b-7ebe-44e3-9ed8-7b7f80bde91c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10934.0" y="2063.0"/> </glyph> <glyph class="state variable" id="_66251112-2d89-440b-9506-acd9ca832395"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10957.432" y="2063.0"/> </glyph> <glyph class="state variable" id="_f25f5887-9767-4bea-bc72-72c299d23c5c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10974.0" y="2063.0"/> </glyph> <glyph class="state variable" id="_4ed43caf-2037-4e85-b376-676c47dde7ea"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10934.0" y="2083.0"/> </glyph> <glyph class="state variable" id="_10c4e124-737f-49cc-96b6-33436844292f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10990.568" y="2063.0"/> </glyph> <glyph class="state variable" id="_cfd75e05-aab2-42ef-9c91-8405d921056e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11014.0" y="2063.0"/> </glyph> <glyph class="state variable" id="_56967cf7-2078-4cb7-b371-5c02ef2847a5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11014.0" y="2074.7158"/> </glyph> <glyph class="state variable" id="_30734d6f-9c98-45e1-b21f-9c0838568900"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11014.0" y="2083.0"/> </glyph> <glyph class="state variable" id="_fd56e9e2-7f54-4c90-a537-6a55129d5d43"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10934.0" y="2063.0"/> </glyph> <glyph class="state variable" id="_9901b094-b5bf-4f97-ab74-2eb5cb2145c3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10934.0" y="2074.7158"/> </glyph> <glyph class="state variable" id="_3936a67c-be15-403a-badb-faf982cf24f2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10934.0" y="2091.2842"/> </glyph> <glyph class="state variable" id="_b097447f-d436-4e29-9736-6e4265ac10b8"> <state value="P" variable="S289"/> <bbox w="35.0" h="10.0" x="10935.156" y="2103.0"/> </glyph> <glyph class="state variable" id="_f1ced26d-c444-4959-bc2e-6220d2bd611e"> <state value="P" variable="S272"/> <bbox w="35.0" h="10.0" x="10955.356" y="2103.0"/> </glyph> <glyph class="state variable" id="_e905a259-e3f6-42d0-bdbf-fbc63483e49d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10974.0" y="2103.0"/> </glyph> <glyph class="state variable" id="_ef3a28b3-a2cf-4aef-955f-808eb2653752"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10957.432" y="2103.0"/> </glyph> <glyph class="state variable" id="_463bccdc-fe98-49d0-ba86-ca7305e4ae3a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10934.0" y="2103.0"/> </glyph> <glyph class="state variable" id="_6f3b8427-3062-4c77-b089-8a09cf88e1f6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10934.0" y="2083.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc2_s316_wnc1_wnc2_sa244" compartmentRef="wnc1_wnc2_c4_wnc1_wnc2_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="10926.0" y="2151.0"/> </glyph> <glyph class="nucleic acid feature" id="wnc1_s_wnc2_s134_wnc1_wnc2_sa127" compartmentRef="wnc1_wnc2_c1_wnc1_wnc2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re46(MAP:survival): Upon Ca2+ activation the NRON-NFAT complex dissociates. PMID:21709260 s_wnc2_re47(MAP:survival): LRKK2 mediates binding of NFAT to NRON and other components, but this is independent of its kinase activity and independent of the phosphorylation status of NFAT PMID:21983832 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: non-protein coding RNA, repressor of NFAT HUGO:NRON HGNC:37079 ENTREZ:641373 GENECARDS:NRON KEGG:641373 WIKI:NRON Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="NRON"/> <bbox w="90.0" h="25.0" x="11681.375" y="774.0"/> <glyph class="unit of information" id="_9d03b236-542d-4eed-95ee-e32972600e1c"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="11716.375" y="769.0"/> </glyph> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc3_s42_wnc1_wnc3_sa36"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CAS:77538-56-8 CHEBI:50114 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PUBCHEM:47206027 KEGGDRUG:D04071 References_end</body> </html> </notes> <label text="estrogen"/> <bbox w="70.0" h="25.0" x="8270.0" y="2835.5"/> </glyph> <glyph class="simple chemical" id="wnc1_s_wnc3_s43_wnc1_wnc3_sa37" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re10:(MAP:survival) PMID:22275375, PMID:15657064, PMID:16396959, PMID:16998587 References_end</body> </html> </notes> <label text="estrogen"/> <bbox w="70.0" h="25.0" x="8270.0" y="3189.0"/> </glyph> <glyph class="nucleic acid feature" id="wnc1_s_wnc3_s2_wnc1_wnc3_sa2" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re1(MAP:survival): TGF-beta upregelates gene expression of NFAT1 and NFAT2 via Ca2+/Calcineurin pathway PMID:20516082 P38 MAPK activates NFATc/NFAT2 promoter PMID:12944472 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 NF-ATC, NFAT2, NFATc HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="NFAT1_2*"/> <bbox w="90.0" h="25.0" x="7812.0" y="3234.5"/> <glyph class="unit of information" id="_cc7794e6-9eef-4c3c-9e3e-86e38dbc5414"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7847.0" y="3229.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wnc1_s_wnc3_s8_wnc1_wnc3_sa8" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) "v-myc avian myelocytomatosis viral oncogene homolog" HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 GENECARDS:MYC REACTOME:59773 KEGG:4609 ATLASONC:MYCID27 WIKI:MYC Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) "v-myc avian myelocytomatosis viral oncogene homolog" HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 GENECARDS:MYC REACTOME:59773 KEGG:4609 ATLASONC:MYCID27 WIKI:MYC Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MYC"/> <bbox w="90.0" h="25.0" x="7913.0" y="3311.5"/> <glyph class="unit of information" id="_4ef15f85-bdd1-4444-bab5-8de875e3f084"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="7948.0" y="3306.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wnc1_s_wnc3_s86_wnc1_wnc3_sa75" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re20:(MAP:survival) PMID:19218564 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: interleukin 2 HUGO:IL2 HGNC:6001 ENTREZ:3558 UNIPROT:P60568 GENECARDS:IL2 REACTOME:57258 KEGG:3558 ATLASONC:GC_IL2 WIKI:IL2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="IL2"/> <bbox w="90.0" h="25.0" x="8214.0" y="3568.5"/> <glyph class="unit of information" id="_06435dd3-18f1-48b6-a49a-bdb4c7da9032"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="8249.0" y="3563.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wnc1_s_wnc3_s96_wnc1_wnc3_sa82" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re25:(MAP:survival) PMID:12453415 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase 4 HUGO:CDK4 HGNC:1773 ENTREZ:1019 UNIPROT:P11802 GENECARDS:CDK4 REACTOME:68329 KEGG:1019 ATLASONC:CDK4ID238ch12q14 WIKI:CDK4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CDK4"/> <bbox w="90.0" h="25.0" x="8206.0" y="3616.5"/> <glyph class="unit of information" id="_92e1b791-6f3f-4305-8a41-0151703a6bd8"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="8241.0" y="3611.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wnc1_s_wnc3_s98_wnc1_wnc3_sa84" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re27(MAP:survival): NFAT1 together with JUN/FOS=AP-1 activates the promoter of GPC6 PMID:21871017 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glypican 6 HUGO:GPC6 HGNC:4454 ENTREZ:10082 UNIPROT:Q9Y625 GENECARDS:GPC6 REACTOME:55874 KEGG:10082 WIKI:GPC6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="GPC6"/> <bbox w="90.0" h="25.0" x="8206.0" y="3652.5"/> <glyph class="unit of information" id="_3c6427b5-bc0d-4905-8f16-5ab011762463"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="8241.0" y="3647.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc3_s4_wnc1_wnc3_sa4" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re1(MAP:survival): TGF-beta upregelates gene expression of NFAT1 and NFAT2 via Ca2+/Calcineurin pathway PMID:20516082 P38 MAPK activates NFATc/NFAT2 promoter PMID:12944472 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: transforming growth factor, beta 1 "Camurati-Engelmann disease", CED, TGFbeta HUGO:TGFB1 HGNC:11766 ENTREZ:7040 UNIPROT:P01137 GENECARDS:TGFB1 REACTOME:65937 KEGG:7040 ATLASONC:GC_TGFB1 WIKI:TGFB1 transforming growth factor, beta 2 HUGO:TGFB2 HGNC:11768 ENTREZ:7042 UNIPROT:P61812 GENECARDS:TGFB2 REACTOME:65939 KEGG:7042 ATLASONC:GC_TGFB2 WIKI:TGFB2 transforming growth factor, beta 3 HUGO:TGFB3 HGNC:11769 ENTREZ:7043 UNIPROT:P10600 GENECARDS:TGFB3 REACTOME:65943 KEGG:7043 ATLASONC:GC_TGFB3 WIKI:TGFB3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TGFβ*"/> <bbox w="80.0" h="40.0" x="7753.0" y="3152.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc3_s5_wnc1_wnc3_sa5" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re16(MAP:survival): Sequential sumoylion of NFAT1, might also occur in NFAT3 and 4. There is no special character for sumoylation in CellDesigner, so this is indicated by a "?". Lys684 is targeted firstly, followed by Lys897. PMID:15117942 s_wnc3_re23(MAP:survival): NFATs are ADP-ribosylated. Also NFAT2 @E427, NFAT3 @E418, NFAT4@E432 There is not special character to indicated this PTM, I have used glycosylation instead. PMID:18299389, PMID:18078995 s_wnc3_re26:(MAP:survival) PMID:12453415 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family; 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT1*"/> <clone/> <bbox w="80.0" h="40.0" x="7676.0" y="3303.5"/> <glyph class="state variable" id="_55eaf97a-edcb-482e-bfc6-e3c5ef798cf7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7727.5684" y="3338.5"/> </glyph> <glyph class="state variable" id="_9bd27d6c-14da-4f51-924f-5a21995bb2d8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7711.0" y="3338.5"/> </glyph> <glyph class="state variable" id="_11e1dad2-472a-4380-9181-0ad1b1127359"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7751.0" y="3298.5"/> </glyph> <glyph class="state variable" id="_b6329080-6062-4d06-b75d-880c3d86732f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7694.4316" y="3338.5"/> </glyph> <glyph class="state variable" id="_bb8c8a0d-9a3b-48ec-83d2-6b53aa4989ea"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7751.0" y="3310.2158"/> </glyph> <glyph class="state variable" id="_30f1845d-9d8b-486d-aa66-767c98e3d465"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7671.0" y="3338.5"/> </glyph> <glyph class="state variable" id="_8fab7cd7-7fbf-4681-891e-3fc04dec9a7b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7711.0" y="3298.5"/> </glyph> <glyph class="state variable" id="_6f1573b9-940f-4d50-bd34-0893497788b7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7671.0" y="3326.7842"/> </glyph> <glyph class="state variable" id="_9a0f5649-0736-45a8-8499-1480c7331669"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7727.5684" y="3298.5"/> </glyph> <glyph class="state variable" id="_edd878ee-2b7d-448b-8fb2-148092fe24f0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7671.0" y="3318.5"/> </glyph> <glyph class="state variable" id="_452f6572-3ad6-4ab6-b9bb-8c2794fc6174"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7671.0" y="3298.5"/> </glyph> <glyph class="state variable" id="_5bc4e913-0b86-49dd-9bff-38e625f37edf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7671.0" y="3310.2158"/> </glyph> <glyph class="state variable" id="_4d8f0ee5-51cb-45a2-ac84-3c8758ccf311"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7694.4316" y="3298.5"/> </glyph> <glyph class="state variable" id="_d0bafdce-d36c-408a-9b46-4135eb89ba68"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7751.0" y="3318.5"/> </glyph> <glyph class="state variable" id="_112618ef-d51c-48dc-977d-710a01680236"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7751.0" y="3326.7842"/> </glyph> <glyph class="state variable" id="_7cd38fca-459f-4f71-a321-1b960373576b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7751.0" y="3338.5"/> </glyph> <glyph class="unit of information" id="_3c16a1b7-9158-4cf9-9714-27aa08f272a0"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="7691.0" y="3298.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc3_s5_wnc1_wnc3_sa53" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re16(MAP:survival): Sequential sumoylion of NFAT1, might also occur in NFAT3 and 4. There is no special character for sumoylation in CellDesigner, so this is indicated by a "?". Lys684 is targeted firstly, followed by Lys897. PMID:15117942 s_wnc3_re23(MAP:survival): NFATs are ADP-ribosylated. Also NFAT2 @E427, NFAT3 @E418, NFAT4@E432 There is not special character to indicated this PTM, I have used glycosylation instead. PMID:18299389, PMID:18078995 s_wnc3_re26:(MAP:survival) PMID:12453415 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family; 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT1*"/> <clone/> <bbox w="80.0" h="40.0" x="8565.0" y="3179.0"/> <glyph class="state variable" id="_9941287f-a1ab-4f10-9566-9f0aa8af6e3e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8616.568" y="3214.0"/> </glyph> <glyph class="state variable" id="_a3669683-dec1-4425-9f6a-e04a96318d33"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8600.0" y="3214.0"/> </glyph> <glyph class="state variable" id="_8f759cf1-c0cd-4f73-a7a4-69479c46b337"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8640.0" y="3174.0"/> </glyph> <glyph class="state variable" id="_8c1b677f-208e-4cb0-9367-261f4cbfd675"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8583.432" y="3214.0"/> </glyph> <glyph class="state variable" id="_37081eb1-0e74-44e7-9b1c-1050833eb404"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8640.0" y="3185.7158"/> </glyph> <glyph class="state variable" id="_eced3644-b77d-4229-9a14-279cb3264d83"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8560.0" y="3214.0"/> </glyph> <glyph class="state variable" id="_1b3440e5-0156-42a1-8732-f7ce55143201"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8600.0" y="3174.0"/> </glyph> <glyph class="state variable" id="_a335d072-4851-44a1-9373-977adcec47ab"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8560.0" y="3202.2842"/> </glyph> <glyph class="state variable" id="_65807e3c-dd2b-4f98-b8ac-fcb74affd16b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8616.568" y="3174.0"/> </glyph> <glyph class="state variable" id="_41ae5faf-e0d9-4ab8-9221-0bec95b8b447"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8560.0" y="3194.0"/> </glyph> <glyph class="state variable" id="_e9008c15-8741-40df-86ab-910fd2722420"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8560.0" y="3174.0"/> </glyph> <glyph class="state variable" id="_eea60aaf-9a90-4758-84fa-62a823a5a5c3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8560.0" y="3185.7158"/> </glyph> <glyph class="state variable" id="_eaa3d160-b21b-4024-804e-c2aa641ab43c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8583.432" y="3174.0"/> </glyph> <glyph class="state variable" id="_57e16609-8c1e-4e71-9be4-1c0bdba595d9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8640.0" y="3194.0"/> </glyph> <glyph class="state variable" id="_c323cca5-807b-4e73-8724-6278ef5a2596"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8640.0" y="3202.2842"/> </glyph> <glyph class="state variable" id="_ada4d2fd-173e-4f27-8066-88d64a389b4a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8640.0" y="3214.0"/> </glyph> <glyph class="unit of information" id="_d55f6898-c323-4912-ab4d-a0422f69e2f6"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="8580.0" y="3174.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc3_s6_wnc1_wnc3_sa6" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re18(MAP:survival): Order of sumoylation is not important. PMID:19218564 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="NFAT2*"/> <clone/> <bbox w="80.0" h="40.0" x="7673.0" y="3372.0"/> <glyph class="state variable" id="_a37787ab-3044-4911-a401-f6f0e51edd9c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7748.0" y="3407.0"/> </glyph> <glyph class="state variable" id="_90188674-2954-4ed8-9a93-9286c46d7879"> <state value="" variable="K914"/> <bbox w="30.0" h="10.0" x="7658.0" y="3386.9683"/> </glyph> <glyph class="state variable" id="_ace2b546-75f9-451e-b3b5-0ac4da9f14c9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7708.0" y="3367.0"/> </glyph> <glyph class="state variable" id="_1cb79405-5115-414c-b5bf-30acc21f6000"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7748.0" y="3367.0"/> </glyph> <glyph class="state variable" id="_1ccd7828-9110-4240-92d0-b1ee1bd2df91"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7668.0" y="3407.0"/> </glyph> <glyph class="state variable" id="_e53c9da8-cf09-46cb-8374-82f46e54a85c"> <state value="" variable="K702"/> <bbox w="30.0" h="10.0" x="7738.0" y="3387.0"/> </glyph> <glyph class="state variable" id="_bd14b6b4-fd9e-4b19-a3ff-97ba2b48eee7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7668.0" y="3367.0"/> </glyph> <glyph class="state variable" id="_205de978-ea1c-48e3-a033-b664e72e2df7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7724.5684" y="3367.0"/> </glyph> <glyph class="state variable" id="_81ad3522-8d1b-4739-abe2-b8819f89b8a1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7708.0" y="3407.0"/> </glyph> <glyph class="state variable" id="_e8c40a03-3889-44ea-86de-e572033c72b6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7691.4316" y="3407.0"/> </glyph> <glyph class="state variable" id="_3b8347c4-aec4-495a-8c31-e258a56a20df"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7691.4316" y="3367.0"/> </glyph> <glyph class="state variable" id="_6baa6be8-bc44-494c-bb90-0bd6fa05d2f0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7724.5684" y="3407.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc3_s6_wnc1_wnc3_sa59" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re18(MAP:survival): Order of sumoylation is not important. PMID:19218564 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="NFAT2*"/> <clone/> <bbox w="80.0" h="40.0" x="8934.5" y="3179.0"/> <glyph class="state variable" id="_5cca80db-94d7-40ea-909f-7b7d945be242"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9009.5" y="3214.0"/> </glyph> <glyph class="state variable" id="_1fcb86f0-8041-4495-8d66-4af6d738e225"> <state value="" variable="K914"/> <bbox w="30.0" h="10.0" x="8919.5" y="3193.9683"/> </glyph> <glyph class="state variable" id="_9a28cbb0-86e2-4fee-89a3-95cc24ac95cd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8969.5" y="3174.0"/> </glyph> <glyph class="state variable" id="_301bf21e-2046-4134-98dd-dd2d75d72f45"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9009.5" y="3174.0"/> </glyph> <glyph class="state variable" id="_202dec8f-cdc6-4a1a-af87-c238463789fd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8929.5" y="3214.0"/> </glyph> <glyph class="state variable" id="_fbfa9cf7-7a83-47f1-8ca3-7f5f1ccb01d2"> <state value="" variable="K702"/> <bbox w="30.0" h="10.0" x="8999.5" y="3194.0"/> </glyph> <glyph class="state variable" id="_383d8596-89e6-4032-b7f6-7a32dec8f2aa"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8929.5" y="3174.0"/> </glyph> <glyph class="state variable" id="_6d17faf2-fa6a-44a4-bc9c-9327635bf29a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8986.068" y="3174.0"/> </glyph> <glyph class="state variable" id="_230237a2-1b60-40e6-9703-e1f30d2f100c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8969.5" y="3214.0"/> </glyph> <glyph class="state variable" id="_fa60e485-e2d6-40c5-a618-0877a1fefe1e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8952.932" y="3214.0"/> </glyph> <glyph class="state variable" id="_ea4e05a1-7bed-4e17-818a-a7b924207a1f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8952.932" y="3174.0"/> </glyph> <glyph class="state variable" id="_a3f44e88-ee3b-4dd2-bed3-7ac7b8a556f3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8986.068" y="3214.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc3_s10_wnc1_wnc3_sa10" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re1(MAP:survival): TGF-beta upregelates gene expression of NFAT1 and NFAT2 via Ca2+/Calcineurin pathway PMID:20516082 P38 MAPK activates NFATc/NFAT2 promoter PMID:12944472 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 11 PRKM11 HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 mitogen-activated protein kinase 12 SAPK3 HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 mitogen-activated protein kinase 13 PRKM13 HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 mitogen-activated protein kinase 14 CSBP1 CSBP2 CSPB1 HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: mitogen-activated protein kinase 11 PRKM11 HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 GENECARDS:MAPK11 REACTOME:59299 KEGG:5600 ATLASONC:GC_MAPK11 WIKI:MAPK11 mitogen-activated protein kinase 12 SAPK3 HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 GENECARDS:MAPK12 REACTOME:69723 KEGG:6300 ATLASONC:MAPK12ID41290ch22q13 WIKI:MAPK12 mitogen-activated protein kinase 13 PRKM13 HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 GENECARDS:MAPK13 REACTOME:59303 KEGG:5603 ATLASONC:MAPK13ID41291ch6p21 WIKI:MAPK13 mitogen-activated protein kinase 14 CSBP1 CSBP2 CSPB1 HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 GENECARDS:MAPK14 REACTOME:405912 KEGG:1432 ATLASONC:MAPK14ID41292ch6p21 WIKI:MAPK14 Mxi2 P38 "P38 MAP kinase" PRKM14 PRKM15 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: mitogen-activated protein kinase 11 PRKM11 HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 GENECARDS:MAPK11 REACTOME:59299 KEGG:5600 ATLASONC:GC_MAPK11 WIKI:MAPK11 mitogen-activated protein kinase 12 SAPK3 HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 GENECARDS:MAPK12 REACTOME:69723 KEGG:6300 ATLASONC:MAPK12ID41290ch22q13 WIKI:MAPK12 mitogen-activated protein kinase 13 PRKM13 HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 GENECARDS:MAPK13 REACTOME:59303 KEGG:5603 ATLASONC:MAPK13ID41291ch6p21 WIKI:MAPK13 mitogen-activated protein kinase 14 CSBP1 CSBP2 CSPB1 HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 GENECARDS:MAPK14 REACTOME:405912 KEGG:1432 ATLASONC:MAPK14ID41292ch6p21 WIKI:MAPK14 Mxi2 P38 "P38 MAP kinase" PRKM14 PRKM15 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="p38*"/> <bbox w="80.0" h="40.0" x="7836.0" y="3153.0"/> <glyph class="state variable" id="_82efc3f4-e620-4458-8a7e-5ac18c27dc50"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7831.0" y="3175.4111"/> </glyph> <glyph class="state variable" id="_b9042450-c848-435f-b518-da1b7895770d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7831.0" y="3160.6816"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc3_s27_wnc1_wnc3_sa22" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: cJun, JunB and JunD bind to AP-1 regulatory elements PMID:11402342 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> </notes> <label text="JUN"/> <bbox w="80.0" h="40.0" x="7618.5" y="3533.5"/> <glyph class="state variable" id="_05463bfd-c0db-4431-a34c-1b2614e4e476"> <state value="" variable="S63"/> <bbox w="25.0" h="10.0" x="7606.4927" y="3528.5"/> </glyph> <glyph class="state variable" id="_bfa335df-d84d-4a28-bfb6-3f3ba6df4819"> <state value="" variable="S73"/> <bbox w="25.0" h="10.0" x="7646.0317" y="3528.5"/> </glyph> <glyph class="state variable" id="_191cbee3-6114-4ec2-b072-5e3d657038a6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7613.5" y="3548.5"/> </glyph> <glyph class="state variable" id="_c9618a87-1093-44fa-b82e-fd9c66e89490"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7613.5" y="3528.5"/> </glyph> <glyph class="state variable" id="_fd8dcb48-764a-4b15-aad1-d343cf657e27"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7613.5" y="3568.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc3_s28_wnc1_wnc3_sa23" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: cFos, FosB, Fra1 and Fra2 bind to AP-1 regulatory elements PMID:11402342 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: FBJ murine osteosarcoma viral oncogene homolog "v-fos FBJ murine osteosarcoma viral oncogene homolog" HUGO:FOS HGNC:3796 ENTREZ:2353 UNIPROT:P01100 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: c-FOS is activated by ERK and RSK through phosphorylation. PMID:16393692 References_end Identifiers_begin: FBJ murine osteosarcoma viral oncogene homolog "v-fos FBJ murine osteosarcoma viral oncogene homolog" HUGO:FOS HGNC:3796 ENTREZ:2353 UNIPROT:P01100 GENECARDS:FOS REACTOME:54964 KEGG:2353 ATLASONC:GC_FOS WIKI:FOS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: c-FOS is activated by ERK and RSK through phosphorylation. PMID:16393692 References_end</body> </html> </notes> <label text="FOS"/> <bbox w="80.0" h="40.0" x="7705.5" y="3533.5"/> <glyph class="state variable" id="_f05b7665-ff38-4a40-bf5f-562ffa85262f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7700.5" y="3548.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc3_s30_wnc1_wnc3_sa25" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="7620.0" y="3586.5"/> <glyph class="state variable" id="_23b95c95-f2f8-4221-aec8-b05bc0f0a7ec"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7695.0" y="3609.7842"/> </glyph> <glyph class="state variable" id="_fb4c8acd-c40d-4c31-868b-58ca4c14476c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7695.0" y="3621.5"/> </glyph> <glyph class="state variable" id="_a8bd77db-f6f0-42c8-87ba-9c244a176ddf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7671.5684" y="3621.5"/> </glyph> <glyph class="state variable" id="_d0ffaa5d-58fe-496e-989c-dd7e4dcf5396"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7615.0" y="3581.5"/> </glyph> <glyph class="state variable" id="_93f97782-caf4-4883-979f-2e8b75fc73e7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7638.4316" y="3581.5"/> </glyph> <glyph class="state variable" id="_e86ac692-884d-45f0-9a91-d7b82210c3fb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7655.0" y="3581.5"/> </glyph> <glyph class="state variable" id="_481a787a-7088-44cd-9e34-919602b46180"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7615.0" y="3601.5"/> </glyph> <glyph class="state variable" id="_1bbf5201-8498-4a38-a63c-34e6471ce898"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7671.5684" y="3581.5"/> </glyph> <glyph class="state variable" id="_bb8043d0-ec6a-495c-90ff-876662c2cc68"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7695.0" y="3581.5"/> </glyph> <glyph class="state variable" id="_95ab1332-fddf-483b-876f-3410f021624b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7695.0" y="3593.2158"/> </glyph> <glyph class="state variable" id="_33698190-51ed-40f0-a78b-ffd3e3ac88b0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7695.0" y="3601.5"/> </glyph> <glyph class="state variable" id="_b8517f2d-6fdf-4f25-9f8e-6813d894fd11"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7615.0" y="3581.5"/> </glyph> <glyph class="state variable" id="_c5ae006b-8024-4b23-bbb3-17970ca171d4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7615.0" y="3593.2158"/> </glyph> <glyph class="state variable" id="_ed9fb10d-0116-459d-95ea-7b162c331c6d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7615.0" y="3609.7842"/> </glyph> <glyph class="state variable" id="_7fd645dc-0d73-46e0-9c9a-eae41328cee3"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="7618.6562" y="3621.5"/> </glyph> <glyph class="state variable" id="_f9f588a4-8191-4542-8838-39bd7a19a044"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="7638.857" y="3621.5"/> </glyph> <glyph class="state variable" id="_2511d1de-2ce8-4d3d-9e00-7cf67a1fed02"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7655.0" y="3621.5"/> </glyph> <glyph class="state variable" id="_43de49da-2551-48d9-82cb-060037fac8e8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7638.4316" y="3621.5"/> </glyph> <glyph class="state variable" id="_da6d297f-4ed6-4b77-be27-15550a8d34a9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7615.0" y="3621.5"/> </glyph> <glyph class="state variable" id="_fa8aa316-01b5-42dc-892e-264545fc0bec"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7615.0" y="3601.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc3_s33_wnc1_wnc3_sa28" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re15:(MAP:survival) PMID:21376121 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: GATA binding protein 1 (globin transcription factor 1) HUGO:GATA1 HGNC:4170 ENTREZ:2623 UNIPROT:P15976 GENECARDS:GATA1 REACTOME:55334 KEGG:2623 ATLASONC:GATA1ID40689chXp11 WIKI:GATA1 GATA binding protein 2 HUGO:GATA2 HGNC:4171 ENTREZ:2624 UNIPROT:P23769 GENECARDS:GATA2 REACTOME:55336 KEGG:2624 ATLASONC:GATA2ID44160ch3q21 WIKI:GATA2 GATA binding protein 3 HUGO:GATA3 HGNC:4172 ENTREZ:2625 UNIPROT:P23771 GENECARDS:GATA3 REACTOME:55338 KEGG:2625 ATLASONC:GATA3ID107ch10p14 WIKI:GATA3 GATA binding protein 4 HUGO:GATA4 HGNC:4173 ENTREZ:2626 UNIPROT:P43694 GENECARDS:GATA4 REACTOME:55340 KEGG:2626 ATLASONC:GC_GATA4 WIKI:GATA4 GATA binding protein 5 HUGO:GATA5 HGNC:15802 ENTREZ:140628 UNIPROT:Q9BWX5 GENECARDS:GATA5 REACTOME:55342 KEGG:140628 ATLASONC:GC_GATA5 WIKI:GATA5 GATA binding protein 6 HUGO:GATA6 HGNC:4174 ENTREZ:2627 UNIPROT:Q92908 GENECARDS:GATA6 REACTOME:55344 ATLASONC:GATA6ID40690ch18q11 WIKI:GATA6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="GATA*"/> <bbox w="80.0" h="40.0" x="7601.5" y="3719.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc3_s34_wnc1_wnc3_sa29" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: myocyte enhancer factor 2A HUGO:MEF2A HGNC:6993 ENTREZ:4205 UNIPROT:Q02078 GENECARDS:MEF2A REACTOME:59133 KEGG:4205 ATLASONC:GC_MEF2A WIKI:MEF2A myocyte enhancer factor 2B HUGO:MEF2B HGNC:6995 ENTREZ:100271849 UNIPROT:Q02080 GENECARDS:MEF2B REACTOME:59135 KEGG:100271849 ATLASONC:GC_MEF2B WIKI:MEF2B myocyte enhancer factor 2C HUGO:MEF2C HGNC:6996 ENTREZ:4208 UNIPROT:Q06413 GENECARDS:MEF2C REACTOME:59137 KEGG:4208 ATLASONC:GC_MEF2C WIKI:MEF2C myocyte enhancer factor 2D HUGO:MEF2D HGNC:6997 ENTREZ:4209 UNIPROT:Q14814 GENECARDS:MEF2D REACTOME:59139 ATLASONC:MEF2DID43636ch1q22 WIKI:MEF2D Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MEF2*"/> <bbox w="80.0" h="40.0" x="7652.0" y="3875.0"/> <glyph class="state variable" id="_277e9b3b-0999-471d-8a9f-c35d17cf5f79"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7647.0" y="3870.0"/> </glyph> <glyph class="state variable" id="_de993ac6-379e-48ee-a1df-f21acc29f5cf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7687.0" y="3870.0"/> </glyph> <glyph class="state variable" id="_f032baca-891a-4cbb-9ea5-a6eda3166188"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7727.0" y="3870.0"/> </glyph> <glyph class="state variable" id="_04a8e08f-6382-47b0-abcc-351356d97088"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7727.0" y="3910.0"/> </glyph> <glyph class="state variable" id="_e830dc17-fac7-42a6-aa62-22fc67814d0d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7687.0" y="3910.0"/> </glyph> <glyph class="state variable" id="_1d35604a-15ca-45f4-bf89-5bbe9f9103f4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7647.0" y="3910.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc3_s40_wnc1_wnc3_sa34" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re10:(MAP:survival) PMID:22275375, PMID:15657064, PMID:16396959, PMID:16998587 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: estrogen receptor 1 Era, NR3A1 HUGO:ESR1 HGNC:3467 ENTREZ:2099 UNIPROT:P03372 GENECARDS:ESR1 REACTOME:69672 KEGG:2099 ATLASONC:GC_ESR1 WIKI:ESR1 estrogen receptor 2 (ER beta) HUGO:ESR2 HGNC:3468 ENTREZ:2100 UNIPROT:Q92731 GENECARDS:ESR2 REACTOME:54472 KEGG:2100 ATLASONC:ESR2ID40500ch14q23 WIKI:ESR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ERα*"/> <bbox w="80.0" h="50.0" x="8265.0" y="3234.0"/> <glyph class="unit of information" id="_8257a072-19d6-42bf-9d5a-a0b135ccca86"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8282.5" y="3229.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc3_s53_wnc1_wnc3_sa44" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re10:(MAP:survival) PMID:22275375, PMID:15657064, PMID:16396959, PMID:16998587 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: forkhead box A1 "hepatocyte nuclear factor 3, alpha", HNF3A HUGO:FOXA1 HGNC:5021 ENTREZ:3169 UNIPROT:P55317 GENECARDS:FOXA1 KEGG:3169 ATLASONC:FOXA1ID44403ch14q21 WIKI:FOXA1 forkhead box A2 HUGO:FOXA2 HGNC:5022 ENTREZ:3170 UNIPROT:Q9Y261 GENECARDS:FOXA2 REACTOME:56610 KEGG:3170 ATLASONC:GC_FOXA2 WIKI:FOXA2 forkhead box A3 HUGO:FOXA3 HGNC:5023 ENTREZ:3171 UNIPROT:P55318 GENECARDS:FOXA3 REACTOME:56612 KEGG:3171 ATLASONC:GC_FOXA3 WIKI:FOXA3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="FOXA*"/> <bbox w="80.0" h="40.0" x="8260.0" y="3355.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc3_s59_wnc1_wnc3_sa50" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re11:(MAP:survival) PMID:15657420 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="NFAT3*"/> <bbox w="80.0" h="40.0" x="8405.5" y="3452.0"/> <glyph class="state variable" id="_0398a332-9f02-48f1-9d5b-9d9cd5652f98"> <state value="" variable="S676"/> <bbox w="30.0" h="10.0" x="8390.992" y="3447.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc3_s60_wnc1_wnc3_sa49" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re11:(MAP:survival) PMID:15657420 s_wnc3_re21:(MAP:survival) This arrow is to indicate that phosphorylated NFAT3 is also involved in complex formation of NFAT/AP-1 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="NFAT3*"/> <bbox w="80.0" h="40.0" x="8261.0" y="3452.0"/> <glyph class="state variable" id="_d336b1cf-4712-4545-8523-1d1663668d09"> <state value="P" variable="S676"/> <bbox w="35.0" h="10.0" x="8243.992" y="3447.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc3_s61_wnc1_wnc3_sa51" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re11:(MAP:survival) PMID:15657420 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ribosomal protein S6 kinase 90kDa polypeptide 1 "ribosomal protein S6 kinase 90kD polypeptide 1" HUGO:RPS6KA1 HGNC:10430 ENTREZ:6195 UNIPROT:Q15418 ribosomal protein S6 kinase 90kDa polypeptide 2 "ribosomal protein S6 kinase 90kD polypeptide 2" HUGO:RPS6KA2 HGNC:10431 ENTREZ:6196 UNIPROT:Q15349 ribosomal protein S6 kinase 90kDa polypeptide 3 CLS "Coffin-Lowry syndrome" "mental retardation X-linked 19" MRX19 "ribosomal protein S6 kinase 90kD polypeptide 3" HUGO:RPS6KA3 HGNC:10432 ENTREZ:6197 UNIPROT:P51812 ribosomal protein S6 kinase 90kDa polypeptide 6 "ribosomal protein S6 kinase 90kD polypeptide 6" HUGO:RPS6KA6 HGNC:10435 ENTREZ:27330 UNIPROT:Q9UK32 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RSK2 is a well known ERK substrate in the cytoplasm. RSKs are exclusively activated by ERK. Activated RSK can be found in both nuclear and cytoplasmic compartments. PMID:15239952 PMID:15187187 References_end Identifiers_begin: ribosomal protein S6 kinase 90kDa polypeptide 1 "ribosomal protein S6 kinase 90kD polypeptide 1" HUGO:RPS6KA1 HGNC:10430 ENTREZ:6195 UNIPROT:Q15418 GENECARDS:RPS6KA1 REACTOME:57795 KEGG:6195 ATLASONC:RPS6KA1ID43477ch1p36 WIKI:RPS6KA1 ribosomal protein S6 kinase 90kDa polypeptide 2 "ribosomal protein S6 kinase 90kD polypeptide 2" HUGO:RPS6KA2 HGNC:10431 ENTREZ:6196 UNIPROT:Q15349 GENECARDS:RPS6KA2 REACTOME:57797 KEGG:6196 ATLASONC:GC_RPS6KA2 WIKI:RPS6KA2 ribosomal protein S6 kinase 90kDa polypeptide 3 CLS "Coffin-Lowry syndrome" "mental retardation X-linked 19" MRX19 "ribosomal protein S6 kinase 90kD polypeptide 3" HUGO:RPS6KA3 HGNC:10432 ENTREZ:6197 UNIPROT:P51812 GENECARDS:RPS6KA3 REACTOME:57799 KEGG:6197 ATLASONC:GC_RPS6KA3 WIKI:RPS6KA3 ribosomal protein S6 kinase 90kDa polypeptide 6 "ribosomal protein S6 kinase 90kD polypeptide 6" HUGO:RPS6KA6 HGNC:10435 ENTREZ:27330 UNIPROT:Q9UK32 GENECARDS:RPS6KA6 REACTOME:57801 KEGG:27330 ATLASONC:GC_RPS6KA6 WIKI:RPS6KA6 ribosomal protein S6 kinase 90kDa polypeptide 4 HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 GENECARDS:RPS6KA4 REACTOME:93591 KEGG:8986 ATLASONC:GC_RPS6KA4 WIKI:RPS6KA4 HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 GENECARDS:RPS6KA4 REACTOME:93591 KEGG:8986 ATLASONC:GC_RPS6KA4 WIKI:RPS6KA4 HUGO:PIM1 HGNC:8986 ENTREZ:5292 UNIPROT:P11309 GENECARDS:PIM1 KEGG:9361 ATLASONC:PIM1ID261 WIKI:PIM1 ribosomal protein S6 kinase, 90kDa, polypeptide 5 HUGO:RPS6KA5 HGNC:10434 ENTREZ:9252 UNIPROT:O75582 GENECARDS:RPS6KA5 REACTOME:93593 KEGG:9252 ATLASONC:GC_RPS6KA5 WIKI:RPS6KA5 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RSK2 is a well known ERK substrate in the cytoplasm. RSKs are exclusively activated by ERK. Activated RSK can be found in both nuclear and cytoplasmic compartments. PMID:15239952 PMID:15187187 PMID:16286006 PMID:21233202 References_end Identifiers_begin: ribosomal protein S6 kinase 90kDa polypeptide 1 "ribosomal protein S6 kinase 90kD polypeptide 1" HUGO:RPS6KA1 HGNC:10430 ENTREZ:6195 UNIPROT:Q15418 GENECARDS:RPS6KA1 REACTOME:57795 KEGG:6195 ATLASONC:RPS6KA1ID43477ch1p36 WIKI:RPS6KA1 ribosomal protein S6 kinase 90kDa polypeptide 2 "ribosomal protein S6 kinase 90kD polypeptide 2" HUGO:RPS6KA2 HGNC:10431 ENTREZ:6196 UNIPROT:Q15349 GENECARDS:RPS6KA2 REACTOME:57797 KEGG:6196 ATLASONC:GC_RPS6KA2 WIKI:RPS6KA2 ribosomal protein S6 kinase 90kDa polypeptide 3 CLS "Coffin-Lowry syndrome" "mental retardation X-linked 19" MRX19 "ribosomal protein S6 kinase 90kD polypeptide 3" HUGO:RPS6KA3 HGNC:10432 ENTREZ:6197 UNIPROT:P51812 GENECARDS:RPS6KA3 REACTOME:57799 KEGG:6197 ATLASONC:GC_RPS6KA3 WIKI:RPS6KA3 ribosomal protein S6 kinase 90kDa polypeptide 6 "ribosomal protein S6 kinase 90kD polypeptide 6" HUGO:RPS6KA6 HGNC:10435 ENTREZ:27330 UNIPROT:Q9UK32 GENECARDS:RPS6KA6 REACTOME:57801 KEGG:27330 ATLASONC:GC_RPS6KA6 WIKI:RPS6KA6 ribosomal protein S6 kinase 90kDa polypeptide 4 HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 GENECARDS:RPS6KA4 REACTOME:93591 KEGG:8986 ATLASONC:GC_RPS6KA4 WIKI:RPS6KA4 HUGO:RPS6KA4 HGNC:10433 ENTREZ:8986 UNIPROT:O75676 GENECARDS:RPS6KA4 REACTOME:93591 KEGG:8986 ATLASONC:GC_RPS6KA4 WIKI:RPS6KA4 HUGO:PIM1 HGNC:8986 ENTREZ:5292 UNIPROT:P11309 GENECARDS:PIM1 KEGG:9361 ATLASONC:PIM1ID261 WIKI:PIM1 ribosomal protein S6 kinase, 90kDa, polypeptide 5 HUGO:RPS6KA5 HGNC:10434 ENTREZ:9252 UNIPROT:O75582 GENECARDS:RPS6KA5 REACTOME:93593 KEGG:9252 ATLASONC:GC_RPS6KA5 WIKI:RPS6KA5 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RSK2 is a well known ERK substrate in the cytoplasm. RSKs are exclusively activated by ERK. Activated RSK can be found in both nuclear and cytoplasmic compartments. PMID:15239952 PMID:15187187 PMID:16286006 PMID:21233202 References_end</body> </html> </notes> <label text="RSK*"/> <bbox w="80.0" h="40.0" x="8383.0" y="3357.0"/> <glyph class="state variable" id="_9816b07c-95ef-45bd-a30e-ad5f7b251683"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8378.0" y="3372.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc3_s63_wnc1_wnc3_sa54" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re16(MAP:survival): Sequential sumoylion of NFAT1, might also occur in NFAT3 and 4. There is no special character for sumoylation in CellDesigner, so this is indicated by a "?". Lys684 is targeted firstly, followed by Lys897. PMID:15117942 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family; 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT1*"/> <bbox w="80.0" h="40.0" x="8565.0" y="3276.0"/> <glyph class="state variable" id="_fd2d2225-ce66-4e1f-9140-a8be24c04e0c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8616.568" y="3311.0"/> </glyph> <glyph class="state variable" id="_ad1dded6-1967-4b77-a03e-6412ec906564"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8600.0" y="3311.0"/> </glyph> <glyph class="state variable" id="_1c37b3c5-4d49-437c-9cf9-70f76a65eb66"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8640.0" y="3271.0"/> </glyph> <glyph class="state variable" id="_0ae51e05-d792-4de7-85a0-7dc99eda76b9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8583.432" y="3311.0"/> </glyph> <glyph class="state variable" id="_4bedfe47-7057-4ac4-9c5b-108222978e09"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8640.0" y="3282.7158"/> </glyph> <glyph class="state variable" id="_1f7ac3c5-decf-4675-b3f5-9ea5c393b5df"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8560.0" y="3311.0"/> </glyph> <glyph class="state variable" id="_5dc67718-15fc-45a8-b154-213c6078871b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8600.0" y="3271.0"/> </glyph> <glyph class="state variable" id="_5d0109d7-9cc0-4968-b04b-686faa383f8d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8560.0" y="3299.2842"/> </glyph> <glyph class="state variable" id="_17b55c9e-51bc-4c26-976b-dc1378823fcd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8616.568" y="3271.0"/> </glyph> <glyph class="state variable" id="_d8b8a821-cbc6-44f8-a911-fd8ed17e7b3a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8560.0" y="3291.0"/> </glyph> <glyph class="state variable" id="_7baaa27b-d21d-4418-a867-d58141d1eed5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8560.0" y="3271.0"/> </glyph> <glyph class="state variable" id="_afa03e12-4cde-4810-a304-3bdce5aec384"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8560.0" y="3282.7158"/> </glyph> <glyph class="state variable" id="_9ffbef29-a922-47f1-8c66-ddb9f1f321cd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8583.432" y="3271.0"/> </glyph> <glyph class="state variable" id="_b0567e15-0e49-44a4-89b1-7abb77cbe016"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="8637.5" y="3291.0"/> </glyph> <glyph class="state variable" id="_bf716349-3d42-428e-80d6-4599039f48a1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8640.0" y="3299.2842"/> </glyph> <glyph class="state variable" id="_1b541402-509c-410e-bb1e-7636fbc7347a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8640.0" y="3311.0"/> </glyph> <glyph class="unit of information" id="_3517e092-7e99-4907-9a03-83883fceaed1"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="8580.0" y="3271.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc3_s64_wnc1_wnc3_sa55" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Sumoylation of NFAT1 enhances nuclear retention and increases transcription. PMID:15117942 s_wnc3_re17(MAP:survival): Sequential sumoylion of NFAT1, might also occur in NFAT3 and 4. There is no special character for sumoylation in CellDesigner, so this is indicated by a "?". Lys684 is targeted firstly, followed by Lys897. s_wnc3_re5:(MAP:survival) PMID:15657420 s_wnc3_re22:(MAP:survival) To indicate that sumoylated NFAT1 forms as well NFAT/AP comlexes. References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family; 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT1*"/> <bbox w="80.0" h="40.0" x="8565.0" y="3376.0"/> <glyph class="state variable" id="_1f490a02-2665-4512-a09e-41bca7d63662"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8616.568" y="3411.0"/> </glyph> <glyph class="state variable" id="_378a7297-83fd-4f7c-a7a6-994ee019abf9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8600.0" y="3411.0"/> </glyph> <glyph class="state variable" id="_515ebd68-a2bb-4e41-b8d4-dbc703b70b58"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8640.0" y="3371.0"/> </glyph> <glyph class="state variable" id="_e1ed33f1-62cc-471a-85c9-a34e77b32e24"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8583.432" y="3411.0"/> </glyph> <glyph class="state variable" id="_f8ae043d-c91d-43fe-8b92-4837e49ddf3a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8640.0" y="3382.7158"/> </glyph> <glyph class="state variable" id="_97a733ce-6d45-414a-a062-bdc240a301d5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8560.0" y="3411.0"/> </glyph> <glyph class="state variable" id="_22eec57c-c458-4d78-8ecf-7537c7db7fd2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8600.0" y="3371.0"/> </glyph> <glyph class="state variable" id="_d4ded019-ead2-46cb-939d-96488057d07d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8560.0" y="3399.2842"/> </glyph> <glyph class="state variable" id="_c76e748b-ddd8-4170-8cdf-cbdce989b9b7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8616.568" y="3371.0"/> </glyph> <glyph class="state variable" id="_adbb3132-4a06-4519-adee-a931d8d3d528"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8560.0" y="3391.0"/> </glyph> <glyph class="state variable" id="_d1b94917-e29e-4f77-90a1-a28f3b283353"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8560.0" y="3371.0"/> </glyph> <glyph class="state variable" id="_58bb0923-04d6-4ce7-851f-2896abacff42"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="8557.5" y="3382.7158"/> </glyph> <glyph class="state variable" id="_5d5fffe6-ec17-4694-b62b-53c2f67b6e56"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8583.432" y="3371.0"/> </glyph> <glyph class="state variable" id="_b00c695e-d6aa-49ba-ae19-b871f0240266"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="8637.5" y="3391.0"/> </glyph> <glyph class="state variable" id="_95d2545b-1c20-490f-9e10-ea811fbf2121"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8640.0" y="3399.2842"/> </glyph> <glyph class="state variable" id="_e497a69a-66f0-411f-9121-09cde93389cb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8640.0" y="3411.0"/> </glyph> <glyph class="unit of information" id="_770434d1-766f-40a3-99b6-0891d7ae54a6"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="8580.0" y="3371.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc3_s65_wnc1_wnc3_sa56" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> </notes> <label text="E1*"/> <bbox w="80.0" h="40.0" x="8750.0" y="3209.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc3_s66_wnc1_wnc3_sa57" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re16(MAP:survival): Sequential sumoylion of NFAT1, might also occur in NFAT3 and 4. There is no special character for sumoylation in CellDesigner, so this is indicated by a "?". Lys684 is targeted firstly, followed by Lys897. PMID:15117942 s_wnc3_re18(MAP:survival): Order of sumoylation is not important. PMID:19218564 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Ubiquitin-conjugating enzyme E2I HUGO:UBE21 GENECARDS:UBE21 WIKI:UBE21 HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I "ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9)", "ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)" HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I HUGO:MSH6 HGNC:7329 ENTREZ:2956 UNIPROT:P52701 GENECARDS:MSH6 KEGG:2956 ATLASONC:MSH6ID344ch2p16 WIKI:MSH6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20711444 References_end Identifiers_begin: Ubiquitin-conjugating enzyme E2I HUGO:UBE21 GENECARDS:UBE21 WIKI:UBE21 HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I "ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9)", "ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)" HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I HUGO:MSH6 HGNC:7329 ENTREZ:2956 UNIPROT:P52701 GENECARDS:MSH6 KEGG:2956 ATLASONC:MSH6ID344ch2p16 WIKI:MSH6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20711444 References_end</body> </html> </notes> <label text="UBC9*"/> <bbox w="80.0" h="40.0" x="8750.0" y="3275.5"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc3_s67_wnc1_wnc3_sa58" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Protein inhibitor of activated STAT 1 HUGO:PIAS1 HGNC:2752 ENTREZ:8554 UNIPROT:O75925 GENECARDS:PIAS1 REACTOME:61690 KEGG:8554 ATLASONC:GC_PIAS1 WIKI:PIAS1 DDXBP1 "DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20711444 References_end Identifiers_begin: Protein inhibitor of activated STAT 1 HUGO:PIAS1 HGNC:2752 ENTREZ:8554 UNIPROT:O75925 GENECARDS:PIAS1 REACTOME:61690 KEGG:8554 ATLASONC:GC_PIAS1 WIKI:PIAS1 DDXBP1 "DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20711444 References_end</body> </html> Identifiers_begin: Protein inhibitor of activated STAT 1 HUGO:PIAS1 HGNC:2752 ENTREZ:8554 UNIPROT:O75925 GENECARDS:PIAS1 REACTOME:61690 KEGG:8554 ATLASONC:GC_PIAS1 WIKI:PIAS1 DDXBP1 "DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20711444 References_end</body> </html> </notes> <label text="PIAS1"/> <bbox w="80.0" h="40.0" x="8750.0" y="3342.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc3_s69_wnc1_wnc3_sa60" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re18(MAP:survival): Order of sumoylation is not important. PMID:19218564 s_wnc3_re19:(MAP:survival) PMID:19218564, PMID:17928811 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="NFAT2*"/> <bbox w="80.0" h="40.0" x="8934.5" y="3276.0"/> <glyph class="state variable" id="_6e1d97d3-7a1f-45a7-8825-14f51d1041c8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9009.5" y="3311.0"/> </glyph> <glyph class="state variable" id="_23d46681-535a-401a-9ee9-f0c3bd303063"> <state value="?" variable="K914"/> <bbox w="35.0" h="10.0" x="8917.0" y="3290.9683"/> </glyph> <glyph class="state variable" id="_fcd5f875-054a-4764-9849-4095f7562c09"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8969.5" y="3271.0"/> </glyph> <glyph class="state variable" id="_7c03be86-868f-4aab-8627-20e92d94ac25"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9009.5" y="3271.0"/> </glyph> <glyph class="state variable" id="_58a1652e-add8-43d4-a810-44ff4e16ec7d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8929.5" y="3311.0"/> </glyph> <glyph class="state variable" id="_68bf38cd-6d4b-437d-81eb-ab71cfe24e60"> <state value="?" variable="K702"/> <bbox w="35.0" h="10.0" x="8997.0" y="3291.0"/> </glyph> <glyph class="state variable" id="_7fbfbfce-dcfc-4fe3-ad4b-9c34bb9adfd0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8929.5" y="3271.0"/> </glyph> <glyph class="state variable" id="_f1e05b99-62e9-424d-86dd-d47a2712c025"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8986.068" y="3271.0"/> </glyph> <glyph class="state variable" id="_30eca7c7-fe71-46ca-997a-369118444ff0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8969.5" y="3311.0"/> </glyph> <glyph class="state variable" id="_e8e10721-c183-4d3a-b186-9699eb0adc57"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8952.932" y="3311.0"/> </glyph> <glyph class="state variable" id="_5e0fde5c-4f1e-4b1f-95bc-d27bfcd822a1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8952.932" y="3271.0"/> </glyph> <glyph class="state variable" id="_0e3284a4-9338-4f52-8d62-69bf96895574"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8986.068" y="3311.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc3_s88_wnc1_wnc3_sa76" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re23(MAP:survival): NFATs are ADP-ribosylated. Also NFAT2 @E427, NFAT3 @E418, NFAT4@E432 There is not special character to indicated this PTM, I have used glycosylation instead. PMID:18299389, PMID:18078995 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: poly (ADP-ribose) polymerase 1 HUGO:PARP1 HGNC:270 ENTREZ:142 UNIPROT:P09874 GENECARDS:PARP1 REACTOME:62070 KEGG:142 ATLASONC:GC_PARP1 WIKI:PARP1 poly (ADP-ribose) polymerase 2 HUGO:PARP2 HGNC:272 ENTREZ:10038 UNIPROT:Q9UGN5 GENECARDS:PARP2 KEGG:10038 ATLASONC:GC_PARP2 WIKI:PARP2 poly (ADP-ribose) polymerase 3 HUGO:PARP3 HGNC:273 ENTREZ:10039 UNIPROT:Q9Y6F1 GENECARDS:PARP3 KEGG:10039 ATLASONC:GC_PARP3 WIKI:PARP3 poly (ADP-ribose) polymerase 4 HUGO:PARP4 HGNC:271 ENTREZ:143 UNIPROT:Q9UKK3 GENECARDS:PARP4 KEGG:143 ATLASONC:GC_PARP4 WIKI:PARP4 poly (ADP-ribose) polymerase 6 HUGO:PARP6 HGNC:26921 ENTREZ:56965 UNIPROT:Q2NL67 GENECARDS:PARP6 KEGG:56965 ATLASONC:GC_PARP6 WIKI:PARP6 TCDD-inducible poly(ADP-ribose) polymerase HUGO:TIPARP HGNC:23696 ENTREZ:25976 UNIPROT:Q7Z3E1 GENECARDS:TIPARP KEGG:25976 ATLASONC:GC_TIPARP WIKI:TIPARP poly (ADP-ribose) polymerase 8 HUGO:PARP8 HGNC:26124 ENTREZ:79668 UNIPROT:Q8N3A8 GENECARDS:PARP8 KEGG:79668 WIKI:PARP8 poly (ADP-ribose) polymerase 9 HUGO:PARP9 HGNC:24118 ENTREZ:83666 UNIPROT:Q8IXQ6 GENECARDS:PARP9 KEGG:83666 ATLASONC:GC_PARP9 WIKI:PARP9 poly (ADP-ribose) polymerase 10 HUGO:PARP10 HGNC:25895 ENTREZ:84875 UNIPROT:Q53GL7 GENECARDS:PARP10 KEGG:84875 WIKI:PARP10 poly (ADP-ribose) polymerase 11 HUGO:PARP11 HGNC:1186 ENTREZ:57097 UNIPROT:Q9NR21 GENECARDS:PARP11 KEGG:57097 WIKI:PARP11 poly (ADP-ribose) polymerase 12 HUGO:PARP12 HGNC:21919 ENTREZ:64761 UNIPROT:Q9H0J9 GENECARDS:PARP12 KEGG:64761 WIKI:PARP12 poly (ADP-ribose) polymerase 14 HUGO:PARP14 HGNC:29232 ENTREZ:54625 UNIPROT:Q460N5 GENECARDS:PARP14 KEGG:54625 ATLASONC:GC_PARP14 WIKI:PARP14 poly (ADP-ribose) polymerase 15 HUGO:PARP15 HGNC:26876 ENTREZ:165631 UNIPROT:Q460N3 GENECARDS:PARP15 KEGG:165631 WIKI:PARP15 poly (ADP-ribose) polymerase 16 HUGO:PARP16 HGNC:26040 ENTREZ:54956 UNIPROT:Q8N5Y8 GENECARDS:PARP16 KEGG:54956 WIKI:PARP16 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PARP*"/> <bbox w="80.0" h="40.0" x="8563.0" y="3458.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc3_s90_wnc1_wnc3_sa77" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re23(MAP:survival): NFATs are ADP-ribosylated. Also NFAT2 @E427, NFAT3 @E418, NFAT4@E432 There is not special character to indicated this PTM, I have used glycosylation instead. PMID:18299389, PMID:18078995 s_wnc3_re5:(MAP:survival) PMID:15657420 s_wnc3_re24:(MAP:survival) This isoform of NFAT1 forms also NFAT/AP-1 complexes. References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family; 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT1*"/> <bbox w="80.0" h="40.0" x="8740.5" y="3457.0"/> <glyph class="state variable" id="_9ef0ade5-aba2-4e9c-ba14-65a5187d34f1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8792.068" y="3492.0"/> </glyph> <glyph class="state variable" id="_dbada520-9f88-4e6a-8510-6b97e13d3455"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8775.5" y="3492.0"/> </glyph> <glyph class="state variable" id="_fe8afcda-a9ee-4ab3-bd00-d232d69412d4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8815.5" y="3452.0"/> </glyph> <glyph class="state variable" id="_8a0b0ae5-8cb1-45d1-9194-bef0cfeadff2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8758.932" y="3492.0"/> </glyph> <glyph class="state variable" id="_20a0d595-3ef6-40f7-8f98-b98629daafb3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8815.5" y="3463.7158"/> </glyph> <glyph class="state variable" id="_b580bf5e-79d6-4dcd-b095-0c57530e18de"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8735.5" y="3492.0"/> </glyph> <glyph class="state variable" id="_538a362a-123f-47e5-a6c8-623955866037"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8775.5" y="3452.0"/> </glyph> <glyph class="state variable" id="_b2725b63-de68-4140-91a2-d4996575bcb7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8735.5" y="3480.2842"/> </glyph> <glyph class="state variable" id="_c5a9ba5d-8884-4baf-a03f-495fc2811e75"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8792.068" y="3452.0"/> </glyph> <glyph class="state variable" id="_49841e44-126a-43b6-8b6a-a5be451ade60"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8735.5" y="3472.0"/> </glyph> <glyph class="state variable" id="_06858c92-d90f-466b-a4c7-8a645a1e1f9f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8735.5" y="3452.0"/> </glyph> <glyph class="state variable" id="_077e4953-9026-42bc-ae05-8be0a746f70c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8735.5" y="3463.7158"/> </glyph> <glyph class="state variable" id="_b5d2403e-9f00-45d1-992b-aa809f770cde"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8758.932" y="3452.0"/> </glyph> <glyph class="state variable" id="_20f7a25f-07d1-4bb0-9483-0f319ac6af6d"> <state value="G" variable=""/> <bbox w="15.0" h="10.0" x="8813.0" y="3472.0"/> </glyph> <glyph class="state variable" id="_26ecd394-d040-4700-9f99-9de746d88cc4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8815.5" y="3480.2842"/> </glyph> <glyph class="state variable" id="_87c2e951-45df-4a3e-a84a-1c9b07b0fdda"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8815.5" y="3492.0"/> </glyph> <glyph class="unit of information" id="_e9e296fb-b7a6-45d0-9197-2c0d8019f369"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="8755.5" y="3452.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc3_s91_wnc1_wnc3_sa78" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re26:(MAP:survival) PMID:12453415 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: histone deacetylase 1 HUGO:HDAC1 HGNC:4852 ENTREZ:3065 UNIPROT:Q13547 GENECARDS:HDAC1 REACTOME:56408 KEGG:3065 ATLASONC:GC_HDAC1 WIKI:HDAC1 histone deacetylase 2 HUGO:HDAC2 HGNC:4853 ENTREZ:3066 UNIPROT:Q92769 GENECARDS:HDAC2 REACTOME:56410 KEGG:3066 ATLASONC:HDAC2ID40803ch6q22 WIKI:HDAC2 histone deacetylase 3 HUGO:HDAC3 HGNC:4854 ENTREZ:8841 UNIPROT:O15379 GENECARDS:HDAC3 REACTOME:401336 KEGG:8841 ATLASONC:HDAC3ID40804ch5q31 WIKI:HDAC3 histone deacetylase 4 HUGO:HDAC4 HGNC:14063 ENTREZ:9759 UNIPROT:P56524 GENECARDS:HDAC4 REACTOME:56414 KEGG:9759 ATLASONC:GC_HDAC4 WIKI:HDAC4 histone deacetylase 5 HUGO:HDAC5 HGNC:14068 ENTREZ:10014 UNIPROT:Q9UQL6 GENECARDS:HDAC5 REACTOME:415622 KEGG:10014 ATLASONC:GC_HDAC5 WIKI:HDAC5 histone deacetylase 6 HUGO:HDAC6 HGNC:14064 ENTREZ:10013 UNIPROT:Q9UBN7 GENECARDS:HDAC6 REACTOME:56418 KEGG:10013 ATLASONC:GC_HDAC6 WIKI:HDAC6 histone deacetylase 7 HUGO:HDAC7 HGNC:14067 ENTREZ:51564 UNIPROT:Q8WUI4 GENECARDS:HDAC7 REACTOME:412089 KEGG:9734 ATLASONC:GC_HDAC7 WIKI:HDAC7 histone deacetylase 8 HUGO:HDAC8 HGNC:13315 ENTREZ:55869 UNIPROT:Q9BY41 GENECARDS:HDAC8 REACTOME:148335 KEGG:55869 ATLASONC:GC_HDAC8 WIKI:HDAC8 histone deacetylase 10 HUGO:HDAC10 HGNC:18128 ENTREZ:83933 UNIPROT:Q969S8 GENECARDS:HDAC10 REACTOME:412605 KEGG:83933 ATLASONC:GC_HDAC10 WIKI:HDAC10 histone deacetylase 11 HUGO:HDAC11 HGNC:19086 ENTREZ:79885 UNIPROT:Q96DB2 GENECARDS:HDAC11 REACTOME:56406 KEGG:79885 ATLASONC:GC_HDAC11 WIKI:HDAC11 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HDAC*"/> <bbox w="80.0" h="40.0" x="8926.0" y="3421.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc3_s108_wnc1_wnc3_sa91" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re31(MAP:survival): Phosphorylation of NFAT leads to increased DNA binding of NFAT -> increased gene transcription PMID15657416 Not sure if dissociation of calcineurin and ERK/MEK occurs References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 1 PRKM1, PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1 REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ERK2*"/> <bbox w="80.0" h="40.0" x="8217.0" y="3911.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc3_s109_wnc1_wnc3_sa92" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re31(MAP:survival): Phosphorylation of NFAT leads to increased DNA binding of NFAT -> increased gene transcription PMID15657416 Not sure if dissociation of calcineurin and ERK/MEK occurs References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase kinase 1 PRKMK1 HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 GENECARDS:MAP2K1 REACTOME:59503 KEGG:5604 ATLASONC:GC_MAP2K1 WIKI:MAP2K1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MEK1*"/> <bbox w="80.0" h="40.0" x="8311.0" y="3911.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc3_s9_wnc1_wnc3_sa9" compartmentRef="wnc1_wnc3_c1_wnc1_wnc3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re22(MAP:survival): c-Raf; MEK1/2; ERK1/2;HRAS PMID:19906679 TGF-b1 in airway smooth muscle cells PMID:21908588 s_wnc4_re26(MAP:survival): In airway smooth muscle cells References_end</body> </html> </notes> <label text="TGF-β pathway"/> <bbox w="80.0" h="30.0" x="7753.0" y="3024.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc3_s11_wnc1_wnc3_sa11" compartmentRef="wnc1_wnc3_c1_wnc1_wnc3_ca1"> <label text="MAPK pathway"/> <bbox w="80.0" h="30.0" x="7838.0" y="3024.0"/> </glyph> <glyph class="nucleic acid feature" id="wnc1_s_wnc3_s1_wnc1_wnc3_sa1" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re1(MAP:survival): TGF-beta upregelates gene expression of NFAT1 and NFAT2 via Ca2+/Calcineurin pathway PMID:20516082 P38 MAPK activates NFATc/NFAT2 promoter PMID:12944472 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 NF-ATC, NFAT2, NFATc HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="NFAT1_2*"/> <bbox w="70.0" h="25.0" x="7693.0" y="3233.5"/> </glyph> <glyph class="nucleic acid feature" id="wnc1_s_wnc3_s7_wnc1_wnc3_sa7" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) "v-myc avian myelocytomatosis viral oncogene homolog" HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) "v-myc avian myelocytomatosis viral oncogene homolog" HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 GENECARDS:MYC REACTOME:59773 KEGG:4609 ATLASONC:MYCID27 WIKI:MYC Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) "v-myc avian myelocytomatosis viral oncogene homolog" HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 GENECARDS:MYC REACTOME:59773 KEGG:4609 ATLASONC:MYCID27 WIKI:MYC Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MYC"/> <bbox w="70.0" h="25.0" x="7800.0" y="3311.5"/> </glyph> <glyph class="nucleic acid feature" id="wnc1_s_wnc3_s29_wnc1_wnc3_sa24" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re5:(MAP:survival) PMID:15657420 s_wnc3_re31(MAP:survival): Phosphorylation of NFAT leads to increased DNA binding of NFAT -> increased gene transcription PMID15657416 Not sure if dissociation of calcineurin and ERK/MEK occurs References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: This is not a gene but used to indicate binding DNA sequence for AP-1 transcription factor References_end</body> </html> </notes> <label text="AP-1_ARRE binding sites*"/> <bbox w="167.0" h="22.0" x="7613.5" y="3465.0"/> </glyph> <glyph class="nucleic acid feature" id="wnc1_s_wnc3_s31_wnc1_wnc3_sa26" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: This is not a gene but used to indicate binding DNA sequence for NF-kB transcription factor References_end</body> </html> </notes> <label text="NF-κB"/> <bbox w="164.0" h="22.0" x="7607.5" y="3654.0"/> </glyph> <glyph class="nucleic acid feature" id="wnc1_s_wnc3_s32_wnc1_wnc3_sa27" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: This is not a gene but used to indicate binding DNA sequence for GATA References_end</body> </html> </notes> <label text="GATA binding site*"/> <bbox w="166.0" h="25.0" x="7612.5" y="3794.0"/> </glyph> <glyph class="nucleic acid feature" id="wnc1_s_wnc3_s35_wnc1_wnc3_sa30" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re8:(MAP:survival) PMID:11796223 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: It's not a gene but indicating a promoter binding site References_end</body> </html> </notes> <label text="promoter binding site*"/> <bbox w="166.0" h="25.0" x="7615.0" y="3920.5"/> </glyph> <glyph class="nucleic acid feature" id="wnc1_s_wnc3_s44_wnc1_wnc3_sa38" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re10:(MAP:survival) PMID:22275375, PMID:15657064, PMID:16396959, PMID:16998587 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: epiregulin HUGO:EREG HGNC:3443 ENTREZ:2069 UNIPROT:O14944 GENECARDS:EREG REACTOME:54432 KEGG:2069 ATLASONC:GC_EREG WIKI:EREG Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ERE"/> <bbox w="70.0" h="25.0" x="8268.0" y="3305.5"/> </glyph> <glyph class="nucleic acid feature" id="wnc1_s_wnc3_s85_wnc1_wnc3_sa74" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re20:(MAP:survival) PMID:19218564 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: interleukin 2 HUGO:IL2 HGNC:6001 ENTREZ:3558 UNIPROT:P60568 GENECARDS:IL2 REACTOME:57258 KEGG:3558 ATLASONC:GC_IL2 WIKI:IL2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="IL2"/> <bbox w="70.0" h="25.0" x="8091.0" y="3568.5"/> </glyph> <glyph class="nucleic acid feature" id="wnc1_s_wnc3_s95_wnc1_wnc3_sa81" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re25:(MAP:survival) PMID:12453415 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin-dependent kinase 4 HUGO:CDK4 HGNC:1773 ENTREZ:1019 UNIPROT:P11802 GENECARDS:CDK4 REACTOME:68329 KEGG:1019 ATLASONC:CDK4ID238ch12q14 WIKI:CDK4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CDK4"/> <bbox w="70.0" h="25.0" x="8088.0" y="3616.5"/> </glyph> <glyph class="nucleic acid feature" id="wnc1_s_wnc3_s97_wnc1_wnc3_sa83" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re27(MAP:survival): NFAT1 together with JUN/FOS=AP-1 activates the promoter of GPC6 PMID:21871017 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glypican 6 HUGO:GPC6 HGNC:4454 ENTREZ:10082 UNIPROT:Q9Y625 GENECARDS:GPC6 REACTOME:55874 KEGG:10082 WIKI:GPC6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="GPC6"/> <bbox w="70.0" h="25.0" x="8088.0" y="3652.5"/> </glyph> <glyph class="complex" id="wnc1_s_wnc3_s25_wnc1_wnc3_csa3" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GATA binding site*:GATA*:NFAT* Identifiers_end</body> </html> </notes> <label text="GATA binding site*:GATA*:NFAT*"/> <bbox w="184.0" h="104.0" x="7814.0" y="3737.0"/> <glyph class="macromolecule" id="wnc1_wnc3_s22_wnc1_wnc3_sa19"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: GATA binding protein 1 (globin transcription factor 1) HUGO:GATA1 HGNC:4170 ENTREZ:2623 UNIPROT:P15976 GENECARDS:GATA1 REACTOME:55334 KEGG:2623 ATLASONC:GATA1ID40689chXp11 WIKI:GATA1 GATA binding protein 2 HUGO:GATA2 HGNC:4171 ENTREZ:2624 UNIPROT:P23769 GENECARDS:GATA2 REACTOME:55336 KEGG:2624 ATLASONC:GATA2ID44160ch3q21 WIKI:GATA2 GATA binding protein 3 HUGO:GATA3 HGNC:4172 ENTREZ:2625 UNIPROT:P23771 GENECARDS:GATA3 REACTOME:55338 KEGG:2625 ATLASONC:GATA3ID107ch10p14 WIKI:GATA3 GATA binding protein 4 HUGO:GATA4 HGNC:4173 ENTREZ:2626 UNIPROT:P43694 GENECARDS:GATA4 REACTOME:55340 KEGG:2626 ATLASONC:GC_GATA4 WIKI:GATA4 GATA binding protein 5 HUGO:GATA5 HGNC:15802 ENTREZ:140628 UNIPROT:Q9BWX5 GENECARDS:GATA5 REACTOME:55342 KEGG:140628 ATLASONC:GC_GATA5 WIKI:GATA5 GATA binding protein 6 HUGO:GATA6 HGNC:4174 ENTREZ:2627 UNIPROT:Q92908 GENECARDS:GATA6 REACTOME:55344 ATLASONC:GATA6ID40690ch18q11 WIKI:GATA6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="GATA*"/> <bbox w="80.0" h="40.0" x="7906.0" y="3745.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s23_wnc1_wnc3_sa20"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="7820.5" y="3745.0"/> <glyph class="state variable" id="_908c4894-5fa0-49a9-b66f-279f9dacb1f9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7895.5" y="3768.2842"/> </glyph> <glyph class="state variable" id="_15797228-0cf6-4347-9866-beec7e0e381f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7895.5" y="3780.0"/> </glyph> <glyph class="state variable" id="_3dbd467f-6328-4a7b-8ec4-b626e01091e3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7872.0684" y="3780.0"/> </glyph> <glyph class="state variable" id="_bc883e68-c35f-4284-bd8e-93e02372961a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7815.5" y="3740.0"/> </glyph> <glyph class="state variable" id="_8226a631-4bbf-44e7-9344-be4f73c226cb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7838.9316" y="3740.0"/> </glyph> <glyph class="state variable" id="_b61e211c-58c6-468f-befe-067e5220a340"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7855.5" y="3740.0"/> </glyph> <glyph class="state variable" id="_ce09ed68-3e27-4fa9-8aca-a1a96e71ed80"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7815.5" y="3760.0"/> </glyph> <glyph class="state variable" id="_c3eff0c9-90e7-4838-a64e-eeff935ed32d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7872.0684" y="3740.0"/> </glyph> <glyph class="state variable" id="_3335b4a0-25c9-46cc-a45c-53dc3b69a64a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7895.5" y="3740.0"/> </glyph> <glyph class="state variable" id="_fa00f2d9-d779-49ea-9016-524553a5546a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7895.5" y="3751.7158"/> </glyph> <glyph class="state variable" id="_98628c4a-6ac9-4e39-a971-e38abc731ee8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7895.5" y="3760.0"/> </glyph> <glyph class="state variable" id="_a651cd86-c934-48f1-8fd6-f8095f73ce77"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7815.5" y="3740.0"/> </glyph> <glyph class="state variable" id="_12597362-e94f-4d12-9c1a-5285886cc19b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7815.5" y="3751.7158"/> </glyph> <glyph class="state variable" id="_697edf22-c3ed-4f99-af19-ea5ceee7681a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7815.5" y="3768.2842"/> </glyph> <glyph class="state variable" id="_42383a37-c5ba-448b-825a-1aec16898e47"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="7819.1562" y="3780.0"/> </glyph> <glyph class="state variable" id="_9ed372d1-f228-4dec-beb2-cc999bd7c7ed"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="7839.357" y="3780.0"/> </glyph> <glyph class="state variable" id="_15f515b5-1820-42df-aaaa-5162c0cc61cb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7855.5" y="3780.0"/> </glyph> <glyph class="state variable" id="_5b553cf8-3fc6-47f6-b217-6dbe6db64a06"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7838.9316" y="3780.0"/> </glyph> <glyph class="state variable" id="_7c42bd0b-56f5-46ca-86db-308b12a993b9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7815.5" y="3780.0"/> </glyph> <glyph class="state variable" id="_da665866-ca72-47b9-aec1-7dec1519ade8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7815.5" y="3760.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wnc1_wnc3_s24_wnc1_wnc3_sa21"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: This is not a gene but used to indicate binding DNA sequence for GATA References_end</body> </html> </notes> <label text="GATA binding site*"/> <bbox w="166.0" h="25.0" x="7821.0" y="3789.5"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc3_s36_wnc1_wnc3_csa5" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MEF2*:NFAT*:promoter binding site* Identifiers_end References_begin: s_wnc3_re8:(MAP:survival) PMID:11796223 References_end</body> </html> </notes> <label text="MEF2*:NFAT*:promoter binding site*"/> <bbox w="179.0" h="105.0" x="7816.0" y="3866.0"/> <glyph class="nucleic acid feature" id="wnc1_wnc3_s38_wnc1_wnc3_sa31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: It's not a gene but indicating a promoter binding site References_end</body> </html> </notes> <label text="promoter binding site*"/> <bbox w="166.0" h="25.0" x="7822.5" y="3922.75"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s39_wnc1_wnc3_sa32"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: myocyte enhancer factor 2A HUGO:MEF2A HGNC:6993 ENTREZ:4205 UNIPROT:Q02078 GENECARDS:MEF2A REACTOME:59133 KEGG:4205 ATLASONC:GC_MEF2A WIKI:MEF2A myocyte enhancer factor 2B HUGO:MEF2B HGNC:6995 ENTREZ:100271849 UNIPROT:Q02080 GENECARDS:MEF2B REACTOME:59135 KEGG:100271849 ATLASONC:GC_MEF2B WIKI:MEF2B myocyte enhancer factor 2C HUGO:MEF2C HGNC:6996 ENTREZ:4208 UNIPROT:Q06413 GENECARDS:MEF2C REACTOME:59137 KEGG:4208 ATLASONC:GC_MEF2C WIKI:MEF2C myocyte enhancer factor 2D HUGO:MEF2D HGNC:6997 ENTREZ:4209 UNIPROT:Q14814 GENECARDS:MEF2D REACTOME:59139 ATLASONC:MEF2DID43636ch1q22 WIKI:MEF2D Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MEF2*"/> <bbox w="80.0" h="40.0" x="7908.0" y="3880.0"/> <glyph class="state variable" id="_e7344743-c5d7-46e3-a19e-b146e680aced"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7903.0" y="3875.0"/> </glyph> <glyph class="state variable" id="_82d08eec-4441-4f63-8f72-111b31a23abb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7943.0" y="3875.0"/> </glyph> <glyph class="state variable" id="_b00aa27c-9434-483d-9172-dac3095d992a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7983.0" y="3875.0"/> </glyph> <glyph class="state variable" id="_1c1fc2e3-a7b3-4388-9a3f-69f50ac33888"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7983.0" y="3915.0"/> </glyph> <glyph class="state variable" id="_cfebf84e-c4b4-4c0b-8cdc-fa6fc8912812"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7943.0" y="3915.0"/> </glyph> <glyph class="state variable" id="_67a70059-4551-4547-8c7b-1e1dc5f1083f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7903.0" y="3915.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s37_wnc1_wnc3_sa33"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="7821.5" y="3880.0"/> <glyph class="state variable" id="_ed96d7a8-0603-4645-9eb5-e442714d98e1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7896.5" y="3903.2842"/> </glyph> <glyph class="state variable" id="_eb84b41d-49fe-4146-b917-799b133bd9e0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7896.5" y="3915.0"/> </glyph> <glyph class="state variable" id="_054f687a-1b04-46a3-a59a-dd53151cb16e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7873.0684" y="3915.0"/> </glyph> <glyph class="state variable" id="_f504a90f-9298-4f7f-a3ec-d07357c8eb1d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7816.5" y="3875.0"/> </glyph> <glyph class="state variable" id="_15f5d8ab-a0a4-41b2-b3cd-e4a0893bac8f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7839.9316" y="3875.0"/> </glyph> <glyph class="state variable" id="_e62cb49c-d9c8-4ba9-a5a7-b3c582d67808"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7856.5" y="3875.0"/> </glyph> <glyph class="state variable" id="_4fd8f81a-0caa-44c8-ac14-b511cd08e5f5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7816.5" y="3895.0"/> </glyph> <glyph class="state variable" id="_e1f9323f-7e76-4283-b1f8-8c228c07ca8a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7873.0684" y="3875.0"/> </glyph> <glyph class="state variable" id="_2b4e4c75-d821-458a-a83a-14662b4f1d47"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7896.5" y="3875.0"/> </glyph> <glyph class="state variable" id="_681fb22a-3cf2-4a7b-90ef-a0080be20688"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7896.5" y="3886.7158"/> </glyph> <glyph class="state variable" id="_475e2eef-88e1-479a-8ef1-9cdcae26056b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7896.5" y="3895.0"/> </glyph> <glyph class="state variable" id="_5002c78a-9900-4c69-9ae3-25904e9549df"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7816.5" y="3875.0"/> </glyph> <glyph class="state variable" id="_5afa392a-d812-4baf-ae50-644d668426a4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7816.5" y="3886.7158"/> </glyph> <glyph class="state variable" id="_6b37a36d-baad-47b7-b3f0-9f63986354d0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7816.5" y="3903.2842"/> </glyph> <glyph class="state variable" id="_b9fa3c87-d54f-4759-9bcd-7fef898ae81a"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="7820.1562" y="3915.0"/> </glyph> <glyph class="state variable" id="_f18938e6-2940-4e29-af07-52c1d4eb4af7"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="7840.357" y="3915.0"/> </glyph> <glyph class="state variable" id="_3a0ce376-0df9-422f-a7fa-b802ff3caeb0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7856.5" y="3915.0"/> </glyph> <glyph class="state variable" id="_49743bed-20c2-4f2d-9d0e-2faf6694a180"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7839.9316" y="3915.0"/> </glyph> <glyph class="state variable" id="_2dc36a0c-c5c3-4e9d-8272-2d85f7b8e096"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7816.5" y="3915.0"/> </glyph> <glyph class="state variable" id="_0006bc7c-13cb-4f7e-a174-a3c12135d563"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7816.5" y="3895.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc3_s52_wnc1_wnc3_csa7" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Ca2+:Calmodulin* Identifiers_end References_begin: s_wnc3_re10:(MAP:survival) PMID:22275375, PMID:15657064, PMID:16396959, PMID:16998587 References_end</body> </html> </notes> <label text="Ca2+:Calmodulin*"/> <bbox w="100.0" h="120.0" x="8058.0" y="3147.0"/> <glyph class="macromolecule" id="wnc1_wnc3_s50_wnc1_wnc3_sa42"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: calmodulin 1 (phosphorylase kinase, delta) CALML2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 2 (phosphorylase kinase, delta) HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 calmodulin 3 (phosphorylase kinase, delta) HUGO:CALM3 HGNC:1449 ENTREZ:808 UNIPROT:P62158 GENECARDS:CALM3 REACTOME:51306 KEGG:808 ATLASONC:GC_CALM3 WIKI:CALM3 HUGO:CALM1 HGNC:1442 ENTREZ:801 UNIPROT:P62158 GENECARDS:CALM1 REACTOME:51306 KEGG:801 ATLASONC:GC_CALM1 WIKI:CALM1 HUGO:CALM2 HGNC:1445 ENTREZ:805 UNIPROT:P62158 GENECARDS:CALM2 REACTOME:51306 KEGG:805 WIKI:CALM2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Calmodulin*"/> <bbox w="80.0" h="40.0" x="8069.0" y="3163.0"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc3_s51_wnc1_wnc3_sa43"> <label text="Ca2+"/> <bbox w="25.0" h="25.0" x="8093.5" y="3204.5"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc3_s55_wnc1_wnc3_csa6" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ERE:ER_alpha_*:FOXA*:NFAT*:estrogen Identifiers_end References_begin: s_wnc3_re10:(MAP:survival) PMID:22275375, PMID:15657064, PMID:16396959, PMID:16998587 References_end</body> </html> </notes> <label text="ERE:ERα*:FOXA*:NFAT*:estrogen"/> <bbox w="102.0" h="218.0" x="8057.0" y="3276.0"/> <glyph class="macromolecule" id="wnc1_wnc3_s49_wnc1_wnc3_sa39"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: estrogen receptor 1 Era, NR3A1 HUGO:ESR1 HGNC:3467 ENTREZ:2099 UNIPROT:P03372 GENECARDS:ESR1 REACTOME:69672 KEGG:2099 ATLASONC:GC_ESR1 WIKI:ESR1 estrogen receptor 2 (ER beta) HUGO:ESR2 HGNC:3468 ENTREZ:2100 UNIPROT:Q92731 GENECARDS:ESR2 REACTOME:54472 KEGG:2100 ATLASONC:ESR2ID40500ch14q23 WIKI:ESR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ERα*"/> <bbox w="80.0" h="50.0" x="8068.5" y="3294.75"/> <glyph class="unit of information" id="_37265799-20c9-443c-b3d6-e2ffa10791fa"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="8086.0" y="3289.75"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wnc1_wnc3_s47_wnc1_wnc3_sa40"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: epiregulin HUGO:EREG HGNC:3443 ENTREZ:2069 UNIPROT:O14944 GENECARDS:EREG REACTOME:54432 KEGG:2069 ATLASONC:GC_EREG WIKI:EREG Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ERE"/> <bbox w="70.0" h="25.0" x="8073.5" y="3344.25"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc3_s48_wnc1_wnc3_sa41"> <label text="estrogen"/> <bbox w="70.0" h="25.0" x="8073.5" y="3279.75"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s54_wnc1_wnc3_sa45"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: forkhead box A1 "hepatocyte nuclear factor 3, alpha", HNF3A HUGO:FOXA1 HGNC:5021 ENTREZ:3169 UNIPROT:P55317 GENECARDS:FOXA1 KEGG:3169 ATLASONC:FOXA1ID44403ch14q21 WIKI:FOXA1 forkhead box A2 HUGO:FOXA2 HGNC:5022 ENTREZ:3170 UNIPROT:Q9Y261 GENECARDS:FOXA2 REACTOME:56610 KEGG:3170 ATLASONC:GC_FOXA2 WIKI:FOXA2 forkhead box A3 HUGO:FOXA3 HGNC:5023 ENTREZ:3171 UNIPROT:P55318 GENECARDS:FOXA3 REACTOME:56612 KEGG:3171 ATLASONC:GC_FOXA3 WIKI:FOXA3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="FOXA*"/> <bbox w="80.0" h="40.0" x="8069.5" y="3374.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s58_wnc1_wnc3_sa48"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="8069.5" y="3417.0"/> <glyph class="state variable" id="_6f6c4b14-f939-463b-a102-86b2840156a3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8144.5" y="3440.2842"/> </glyph> <glyph class="state variable" id="_721524ff-5036-42fd-9963-1150e667787b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8144.5" y="3452.0"/> </glyph> <glyph class="state variable" id="_f971ce76-503d-4427-b896-268cd072962a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8121.0684" y="3452.0"/> </glyph> <glyph class="state variable" id="_8ee7e1b5-47a0-4fdb-bbee-4299136895eb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8064.5" y="3412.0"/> </glyph> <glyph class="state variable" id="_9ed0f8df-e03e-4c9c-9a78-4a3de29a48b7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8087.9316" y="3412.0"/> </glyph> <glyph class="state variable" id="_ce3d7a3b-797d-4817-b150-1582e5827969"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8104.5" y="3412.0"/> </glyph> <glyph class="state variable" id="_cac515f6-4118-4c84-9c7a-2ae677fdda34"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8064.5" y="3432.0"/> </glyph> <glyph class="state variable" id="_201a3e55-79d8-421d-afc6-07d45210e081"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8121.0684" y="3412.0"/> </glyph> <glyph class="state variable" id="_89a95db3-d2a1-448c-88d4-f92dcca8a7db"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8144.5" y="3412.0"/> </glyph> <glyph class="state variable" id="_c604e26b-1dfd-446a-a6ff-e66939287abc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8144.5" y="3423.7158"/> </glyph> <glyph class="state variable" id="_01989182-f4d0-460c-b964-d79dbeebd5b8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8144.5" y="3432.0"/> </glyph> <glyph class="state variable" id="_a1ee2e2e-8b0c-433f-99ae-a76c0fa2d7a4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8064.5" y="3412.0"/> </glyph> <glyph class="state variable" id="_74c064ad-8cf0-4e75-acd7-a0d8ec215f37"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8064.5" y="3423.7158"/> </glyph> <glyph class="state variable" id="_d6d3a6a7-471e-4f55-b761-cf60d9b2496f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8064.5" y="3440.2842"/> </glyph> <glyph class="state variable" id="_2b9e2f79-30ae-457a-98b1-cae9d1e348e0"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="8068.1562" y="3452.0"/> </glyph> <glyph class="state variable" id="_5b23b919-c1ac-44a8-8cda-6fa3eeab60a9"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="8088.357" y="3452.0"/> </glyph> <glyph class="state variable" id="_a5836600-3cf8-4b66-84cd-6e285b05c2d0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8104.5" y="3452.0"/> </glyph> <glyph class="state variable" id="_5a59c5f3-8682-4d28-bcd3-4a89252fc54d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8087.9316" y="3452.0"/> </glyph> <glyph class="state variable" id="_dbf1a500-685f-4a36-8fdb-905f8afa6896"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8064.5" y="3452.0"/> </glyph> <glyph class="state variable" id="_02260272-6636-46bb-8638-48d221c1651b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8064.5" y="3432.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc3_s75_wnc1_wnc3_csa9" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DAXX:HDAC2:PML Identifiers_end References_begin: s_wnc3_re19:(MAP:survival) PMID:19218564, PMID:17928811 References_end</body> </html> </notes> <label text="HDAC2/PML/Daxx"/> <bbox w="147.0" h="193.0" x="9121.0" y="3196.0"/> <glyph class="macromolecule" id="wnc1_wnc3_s70_wnc1_wnc3_sa61"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: histone deacetylase 2 HUGO:HDAC2 HGNC:4853 ENTREZ:3066 UNIPROT:Q92769 GENECARDS:HDAC2 REACTOME:56410 KEGG:3066 ATLASONC:HDAC2ID40803ch6q22 WIKI:HDAC2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HDAC2"/> <bbox w="80.0" h="40.0" x="9132.0" y="3203.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s76_wnc1_wnc3_sa62"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end</body> </html> </notes> <label text="PML"/> <bbox w="80.0" h="40.0" x="9144.0" y="3246.0"/> <glyph class="state variable" id="_87a01fe1-8a0e-4db2-bc70-feb52a68c67c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9219.0" y="3241.0"/> </glyph> <glyph class="state variable" id="_5d0e30c7-6111-4d19-aa56-b0556a8c2834"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9219.0" y="3281.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s76_wnc1_wnc3_sa63"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end</body> </html> </notes> <label text="PML"/> <bbox w="80.0" h="40.0" x="9150.5" y="3257.0"/> <glyph class="state variable" id="_5d6f61f9-caab-4ee1-93c3-7bd520281e9c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9225.5" y="3252.0"/> </glyph> <glyph class="state variable" id="_6c9fa3a9-6010-4056-823b-f36d0da3c23e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9225.5" y="3292.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s76_wnc1_wnc3_sa64"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end</body> </html> </notes> <label text="PML"/> <bbox w="80.0" h="40.0" x="9160.5" y="3267.0"/> <glyph class="state variable" id="_5b4e9ac5-f98d-477a-97d8-91bdbc246302"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9235.5" y="3262.0"/> </glyph> <glyph class="state variable" id="_b3bdbd37-aacf-4c3a-860a-f7bd51091b03"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9235.5" y="3302.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s72_wnc1_wnc3_sa65"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end</body> </html> </notes> <label text="PML"/> <bbox w="80.0" h="40.0" x="9170.5" y="3277.0"/> <glyph class="state variable" id="_4fb5bcab-0bec-41d8-bf03-029c0072f530"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="9243.0" y="3272.0"/> </glyph> <glyph class="state variable" id="_da021cb8-4984-4efa-bdf8-407eb6701421"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="9243.0" y="3312.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s73_wnc1_wnc3_sa66"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: death-domain associated protein HUGO:DAXX HGNC:2681 ENTREZ:1616 UNIPROT:Q9UER7 GENECARDS:DAXX KEGG:1616 ATLASONC:DAXXID40265ch6p21 WIKI:DAXX "death-associated protein 6" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 PMID:16406523 References_end Identifiers_begin: death-domain associated protein HUGO:DAXX HGNC:2681 ENTREZ:1616 UNIPROT:Q9UER7 GENECARDS:DAXX KEGG:1616 ATLASONC:DAXXID40265ch6p21 WIKI:DAXX "death-associated protein 6" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 PMID:16406523 References_end</body> </html> </notes> <label text="DAXX"/> <bbox w="80.0" h="40.0" x="9147.0" y="3321.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc3_s83_wnc1_wnc3_csa10" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DAXX:HDAC2:NFAT2*:PML Identifiers_end References_begin: s_wnc3_re19:(MAP:survival) PMID:19218564, PMID:17928811 References_end</body> </html> </notes> <label text="HDAC2/PML/Daxx/NFAT2"/> <bbox w="184.0" h="204.0" x="9106.5" y="3463.5"/> <glyph class="macromolecule" id="wnc1_wnc3_s78_wnc1_wnc3_sa67"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: histone deacetylase 2 HUGO:HDAC2 HGNC:4853 ENTREZ:3066 UNIPROT:Q92769 GENECARDS:HDAC2 REACTOME:56410 KEGG:3066 ATLASONC:HDAC2ID40803ch6q22 WIKI:HDAC2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HDAC2"/> <bbox w="80.0" h="40.0" x="9117.5" y="3470.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s84_wnc1_wnc3_sa68"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end</body> </html> </notes> <label text="PML"/> <bbox w="80.0" h="40.0" x="9129.5" y="3513.5"/> <glyph class="state variable" id="_312f2cbc-34f8-43a7-90d3-d0b514db6295"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9204.5" y="3508.5"/> </glyph> <glyph class="state variable" id="_a9baa332-d817-42e8-ab6e-cc2aaa6b12ff"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9204.5" y="3548.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s84_wnc1_wnc3_sa69"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end</body> </html> </notes> <label text="PML"/> <bbox w="80.0" h="40.0" x="9136.0" y="3524.5"/> <glyph class="state variable" id="_62a6d938-b40c-4099-af34-1025f071e54f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9211.0" y="3519.5"/> </glyph> <glyph class="state variable" id="_353430ba-a7ab-43db-a231-455e4f8d68d8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9211.0" y="3559.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s84_wnc1_wnc3_sa70"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end</body> </html> </notes> <label text="PML"/> <bbox w="80.0" h="40.0" x="9146.0" y="3534.5"/> <glyph class="state variable" id="_ff643f0c-9f7f-4415-83ec-7344e0ced673"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9221.0" y="3529.5"/> </glyph> <glyph class="state variable" id="_075bb77b-88f1-490d-bbe3-4b02bc8a8053"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9221.0" y="3569.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s80_wnc1_wnc3_sa71"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end Identifiers_begin: PML HUGO:PML HGNC:9113 ENTREZ:5371 UNIPROT:P29590 GENECARDS:PML REACTOME:61894 KEGG:5371 ATLASONC:PMLID41 WIKI:PML promyelocytic leukemia Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 References_end</body> </html> </notes> <label text="PML"/> <bbox w="80.0" h="40.0" x="9156.0" y="3544.5"/> <glyph class="state variable" id="_9463dc76-ae35-4d8a-9cc6-df84a49e660a"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="9228.5" y="3539.5"/> </glyph> <glyph class="state variable" id="_fa45eaad-05b3-48a2-b0a7-352d928db5b0"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="9228.5" y="3579.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s81_wnc1_wnc3_sa72"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: death-domain associated protein HUGO:DAXX HGNC:2681 ENTREZ:1616 UNIPROT:Q9UER7 GENECARDS:DAXX KEGG:1616 ATLASONC:DAXXID40265ch6p21 WIKI:DAXX "death-associated protein 6" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 PMID:16406523 References_end Identifiers_begin: death-domain associated protein HUGO:DAXX HGNC:2681 ENTREZ:1616 UNIPROT:Q9UER7 GENECARDS:DAXX KEGG:1616 ATLASONC:DAXXID40265ch6p21 WIKI:DAXX "death-associated protein 6" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20452955 PMID:16406523 References_end</body> </html> </notes> <label text="DAXX"/> <bbox w="80.0" h="40.0" x="9111.5" y="3587.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s82_wnc1_wnc3_sa73"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="NFAT2*"/> <bbox w="80.0" h="40.0" x="9200.5" y="3590.0"/> <glyph class="state variable" id="_4e0f7342-a170-4136-9602-23351ebaa104"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9275.5" y="3625.0"/> </glyph> <glyph class="state variable" id="_cc01bd5b-6a9d-471d-baf0-980a91a88646"> <state value="?" variable="K914"/> <bbox w="35.0" h="10.0" x="9183.0" y="3604.9683"/> </glyph> <glyph class="state variable" id="_1f70182e-5b9f-4c95-8ce4-4cd55fd93fa1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9235.5" y="3585.0"/> </glyph> <glyph class="state variable" id="_0593fee8-9051-4d8d-98b4-395e3dcb61f3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9275.5" y="3585.0"/> </glyph> <glyph class="state variable" id="_001c198c-d2a7-4c39-8033-75e41a407f62"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9195.5" y="3625.0"/> </glyph> <glyph class="state variable" id="_01fc1cfb-cca9-4cd8-924a-2d919d65526c"> <state value="?" variable="K702"/> <bbox w="35.0" h="10.0" x="9263.0" y="3605.0"/> </glyph> <glyph class="state variable" id="_5fbe1224-32a2-43d0-a88b-55823ffd0bd6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9195.5" y="3585.0"/> </glyph> <glyph class="state variable" id="_4f528089-1989-49ca-b1c3-fc7e365c63f1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9252.068" y="3585.0"/> </glyph> <glyph class="state variable" id="_575a9477-b82f-4ff8-b3c5-0efdca7afb41"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9235.5" y="3625.0"/> </glyph> <glyph class="state variable" id="_65bb4349-9d7d-4457-8cd1-fcb3d0a44eac"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9218.932" y="3625.0"/> </glyph> <glyph class="state variable" id="_efd4db53-2cbc-445f-91b3-238b51e37655"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9218.932" y="3585.0"/> </glyph> <glyph class="state variable" id="_21c8d95c-8c9b-46a2-b1bf-c3d840a4463b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9252.068" y="3625.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc3_s92_wnc1_wnc3_csa11" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HDAC*:NFAT1* Identifiers_end References_begin: s_wnc3_re26:(MAP:survival) PMID:12453415 References_end</body> </html> </notes> <label text="HDAC*:NFAT1*"/> <bbox w="99.0" h="133.0" x="8927.0" y="3498.0"/> <glyph class="macromolecule" id="wnc1_wnc3_s94_wnc1_wnc3_sa79"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: histone deacetylase 1 HUGO:HDAC1 HGNC:4852 ENTREZ:3065 UNIPROT:Q13547 GENECARDS:HDAC1 REACTOME:56408 KEGG:3065 ATLASONC:GC_HDAC1 WIKI:HDAC1 histone deacetylase 2 HUGO:HDAC2 HGNC:4853 ENTREZ:3066 UNIPROT:Q92769 GENECARDS:HDAC2 REACTOME:56410 KEGG:3066 ATLASONC:HDAC2ID40803ch6q22 WIKI:HDAC2 histone deacetylase 3 HUGO:HDAC3 HGNC:4854 ENTREZ:8841 UNIPROT:O15379 GENECARDS:HDAC3 REACTOME:401336 KEGG:8841 ATLASONC:HDAC3ID40804ch5q31 WIKI:HDAC3 histone deacetylase 4 HUGO:HDAC4 HGNC:14063 ENTREZ:9759 UNIPROT:P56524 GENECARDS:HDAC4 REACTOME:56414 KEGG:9759 ATLASONC:GC_HDAC4 WIKI:HDAC4 histone deacetylase 5 HUGO:HDAC5 HGNC:14068 ENTREZ:10014 UNIPROT:Q9UQL6 GENECARDS:HDAC5 REACTOME:415622 KEGG:10014 ATLASONC:GC_HDAC5 WIKI:HDAC5 histone deacetylase 6 HUGO:HDAC6 HGNC:14064 ENTREZ:10013 UNIPROT:Q9UBN7 GENECARDS:HDAC6 REACTOME:56418 KEGG:10013 ATLASONC:GC_HDAC6 WIKI:HDAC6 histone deacetylase 7 HUGO:HDAC7 HGNC:14067 ENTREZ:51564 UNIPROT:Q8WUI4 GENECARDS:HDAC7 REACTOME:412089 KEGG:9734 ATLASONC:GC_HDAC7 WIKI:HDAC7 histone deacetylase 8 HUGO:HDAC8 HGNC:13315 ENTREZ:55869 UNIPROT:Q9BY41 GENECARDS:HDAC8 REACTOME:148335 KEGG:55869 ATLASONC:GC_HDAC8 WIKI:HDAC8 histone deacetylase 10 HUGO:HDAC10 HGNC:18128 ENTREZ:83933 UNIPROT:Q969S8 GENECARDS:HDAC10 REACTOME:412605 KEGG:83933 ATLASONC:GC_HDAC10 WIKI:HDAC10 histone deacetylase 11 HUGO:HDAC11 HGNC:19086 ENTREZ:79885 UNIPROT:Q96DB2 GENECARDS:HDAC11 REACTOME:56406 KEGG:79885 ATLASONC:GC_HDAC11 WIKI:HDAC11 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HDAC*"/> <bbox w="80.0" h="40.0" x="8936.25" y="3510.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s93_wnc1_wnc3_sa80"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family; 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT1*"/> <bbox w="80.0" h="40.0" x="8937.0" y="3557.0"/> <glyph class="state variable" id="_6f461ee2-e991-4cdf-93a1-4ea993267d06"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8988.568" y="3592.0"/> </glyph> <glyph class="state variable" id="_763a455a-a3aa-428c-aba3-1427fdda0ba7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8972.0" y="3592.0"/> </glyph> <glyph class="state variable" id="_ba250b1b-4dd2-48e2-8519-6938e5a43c8e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9012.0" y="3552.0"/> </glyph> <glyph class="state variable" id="_de713e79-908f-4767-aaa6-19826b82ab5a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8955.432" y="3592.0"/> </glyph> <glyph class="state variable" id="_fd7d545d-d5c3-45b4-b12a-0973f79b16a7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9012.0" y="3563.7158"/> </glyph> <glyph class="state variable" id="_95733e21-4a89-46c8-8190-1451ed05b3a2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8932.0" y="3592.0"/> </glyph> <glyph class="state variable" id="_2087e62d-9d09-47f0-8df7-188ca974b10e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8972.0" y="3552.0"/> </glyph> <glyph class="state variable" id="_e4fea236-d6a4-4e8b-9acf-4e307336adde"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8932.0" y="3580.2842"/> </glyph> <glyph class="state variable" id="_a6584281-ed9e-4d28-acb7-1bebc069beb1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8988.568" y="3552.0"/> </glyph> <glyph class="state variable" id="_75b6909c-6e23-4890-961f-9d84a436e6e2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8932.0" y="3572.0"/> </glyph> <glyph class="state variable" id="_fa72af24-05ae-491c-9cfd-84e1ea837f93"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8932.0" y="3552.0"/> </glyph> <glyph class="state variable" id="_9bcf05a1-4946-4f1a-88bc-ba34aeea20d1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8932.0" y="3563.7158"/> </glyph> <glyph class="state variable" id="_b3922ff8-f556-4358-8475-189c058c1d60"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8955.432" y="3552.0"/> </glyph> <glyph class="state variable" id="_8f7079eb-1e60-43ad-b07b-e32ae5e86727"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9012.0" y="3572.0"/> </glyph> <glyph class="state variable" id="_d830cf43-e78e-4bde-8eb8-b70517b01a33"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9012.0" y="3580.2842"/> </glyph> <glyph class="state variable" id="_0d644df5-79c4-458c-b959-03beb184713b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9012.0" y="3592.0"/> </glyph> <glyph class="unit of information" id="_237735ce-fd81-4c6a-bae9-9d1d2c176e44"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="8952.0" y="3552.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc3_s123_wnc1_wnc3_csa1" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AP-1_ARRE binding sites*:FOS:JUN:NFAT* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:11402342 s_wnc3_re31(MAP:survival): Phosphorylation of NFAT leads to increased DNA binding of NFAT -> increased gene transcription PMID15657416 Not sure if dissociation of calcineurin and ERK/MEK occurs s_wnc3_re27(MAP:survival): NFAT1 together with JUN/FOS=AP-1 activates the promoter of GPC6 PMID:21871017 References_end</body> </html> </notes> <label text="(NFAT/AP-1)"/> <clone/> <bbox w="187.0" h="139.0" x="7812.0" y="3461.0"/> <glyph class="macromolecule" id="wnc1_wnc3_s124_wnc1_wnc3_sa12"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: cJun, JunB and JunD bind to AP-1 regulatory elements PMID:11402342 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> </notes> <label text="JUN"/> <clone/> <bbox w="80.0" h="40.0" x="7820.0" y="3536.0"/> <glyph class="state variable" id="_d291c44a-2812-4105-9b16-45ec3e9061a5"> <state value="" variable="S63"/> <bbox w="25.0" h="10.0" x="7807.9927" y="3531.0"/> </glyph> <glyph class="state variable" id="_7a1c8dfc-c1a5-46c1-802a-b67f8a93bcd8"> <state value="" variable="S73"/> <bbox w="25.0" h="10.0" x="7847.5317" y="3531.0"/> </glyph> <glyph class="state variable" id="_af5f7dfa-5091-4ffc-9a3d-2b82de8f790f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7815.0" y="3551.0"/> </glyph> <glyph class="state variable" id="_a5c0e04c-e2de-470d-bb98-3b227b6583e0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7815.0" y="3531.0"/> </glyph> <glyph class="state variable" id="_4c6c823f-1d43-4f48-a111-067a98bcd12b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7815.0" y="3571.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s125_wnc1_wnc3_sa13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: cFos, FosB, Fra1 and Fra2 bind to AP-1 regulatory elements PMID:11402342 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: FBJ murine osteosarcoma viral oncogene homolog "v-fos FBJ murine osteosarcoma viral oncogene homolog" HUGO:FOS HGNC:3796 ENTREZ:2353 UNIPROT:P01100 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: c-FOS is activated by ERK and RSK through phosphorylation. PMID:16393692 References_end Identifiers_begin: FBJ murine osteosarcoma viral oncogene homolog "v-fos FBJ murine osteosarcoma viral oncogene homolog" HUGO:FOS HGNC:3796 ENTREZ:2353 UNIPROT:P01100 GENECARDS:FOS REACTOME:54964 KEGG:2353 ATLASONC:GC_FOS WIKI:FOS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: c-FOS is activated by ERK and RSK through phosphorylation. PMID:16393692 References_end</body> </html> </notes> <label text="FOS"/> <clone/> <bbox w="80.0" h="40.0" x="7907.0" y="3536.0"/> <glyph class="state variable" id="_d7b79f9d-709d-4466-87f2-5e42e57973d2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7902.0" y="3551.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wnc1_wnc3_s126_wnc1_wnc3_sa14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: This is not a gene but used to indicate binding DNA sequence for AP-1 transcription factor References_end</body> </html> </notes> <label text="AP-1_ARRE binding sites*"/> <clone/> <bbox w="167.0" h="22.0" x="7821.0" y="3511.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s127_wnc1_wnc3_sa15"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <clone/> <bbox w="80.0" h="40.0" x="7864.5" y="3469.0"/> <glyph class="state variable" id="_583ed4ac-bbf7-4d2a-9465-facbf7443a85"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7939.5" y="3492.2842"/> </glyph> <glyph class="state variable" id="_927557e5-7a9d-4b45-8ebc-81320667431d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7939.5" y="3504.0"/> </glyph> <glyph class="state variable" id="_a208c4ab-17b6-4dba-8586-167b52e6e410"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7916.0684" y="3504.0"/> </glyph> <glyph class="state variable" id="_10614379-7b7e-4c7b-835e-7662530c693a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7859.5" y="3464.0"/> </glyph> <glyph class="state variable" id="_f1111ece-d933-47ec-9dd5-5f58496b90b8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7882.9316" y="3464.0"/> </glyph> <glyph class="state variable" id="_3180e32d-d2c6-494e-901b-71aaf560f3dd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7899.5" y="3464.0"/> </glyph> <glyph class="state variable" id="_23c2900f-dddb-4f5b-9c08-76e0372bd293"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7859.5" y="3484.0"/> </glyph> <glyph class="state variable" id="_607a9f16-9e1f-4a3a-965d-6103a5a7bfba"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7916.0684" y="3464.0"/> </glyph> <glyph class="state variable" id="_c65cf17b-7ee0-41da-903a-3774ab41953f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7939.5" y="3464.0"/> </glyph> <glyph class="state variable" id="_2a619a41-dd4b-4e26-b258-30c36715511b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7939.5" y="3475.7158"/> </glyph> <glyph class="state variable" id="_23f38909-3e12-4727-9e71-1fd3e0b0ef36"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7939.5" y="3484.0"/> </glyph> <glyph class="state variable" id="_7487df35-02e5-4a96-a208-954033825b8a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7859.5" y="3464.0"/> </glyph> <glyph class="state variable" id="_b7a0c828-d042-4513-be2c-e4e9681fa37f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7859.5" y="3475.7158"/> </glyph> <glyph class="state variable" id="_86465a2a-848a-47e4-9ccb-3136903e6b21"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7859.5" y="3492.2842"/> </glyph> <glyph class="state variable" id="_1caed8a9-0bbd-4aa0-a7b9-aed6612d50f5"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="7863.1562" y="3504.0"/> </glyph> <glyph class="state variable" id="_0c23115e-9250-4a5a-833a-e6caa68a626c"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="7883.357" y="3504.0"/> </glyph> <glyph class="state variable" id="_01e107bf-a702-41f1-9736-ebc599e8ff68"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7899.5" y="3504.0"/> </glyph> <glyph class="state variable" id="_45e72d71-b978-4dce-98dc-01560a169326"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7882.9316" y="3504.0"/> </glyph> <glyph class="state variable" id="_6df022a5-7ad0-423b-9268-8c5f88e4b1f2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7859.5" y="3504.0"/> </glyph> <glyph class="state variable" id="_06e022b0-48b9-4979-957c-10daaf5a8dc5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7859.5" y="3484.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc3_s123_wnc1_wnc3_csa16" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AP-1_ARRE binding sites*:FOS:JUN:NFAT* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:11402342 s_wnc3_re31(MAP:survival): Phosphorylation of NFAT leads to increased DNA binding of NFAT -> increased gene transcription PMID15657416 Not sure if dissociation of calcineurin and ERK/MEK occurs s_wnc3_re27(MAP:survival): NFAT1 together with JUN/FOS=AP-1 activates the promoter of GPC6 PMID:21871017 References_end</body> </html> </notes> <label text="(NFAT/AP-1)"/> <clone/> <bbox w="187.0" h="139.0" x="8573.0" y="3520.5"/> <glyph class="macromolecule" id="wnc1_wnc3_s124_wnc1_wnc3_sa103"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: cJun, JunB and JunD bind to AP-1 regulatory elements PMID:11402342 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> </notes> <label text="JUN"/> <clone/> <bbox w="80.0" h="40.0" x="8581.0" y="3595.5"/> <glyph class="state variable" id="_f2d058ca-e790-44fd-bc3b-41fe3d789057"> <state value="" variable="S63"/> <bbox w="25.0" h="10.0" x="8568.992" y="3590.5"/> </glyph> <glyph class="state variable" id="_037ba7cb-faae-49fc-a07a-5f90f41aff16"> <state value="" variable="S73"/> <bbox w="25.0" h="10.0" x="8608.532" y="3590.5"/> </glyph> <glyph class="state variable" id="_542546d1-8ec0-4d37-b21f-f04dffef62d0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8576.0" y="3610.5"/> </glyph> <glyph class="state variable" id="_01376c64-8d4a-40a4-9bcf-1a4d28654fb4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8576.0" y="3590.5"/> </glyph> <glyph class="state variable" id="_9af610ef-fc50-44be-9804-c654b1193255"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8576.0" y="3630.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s125_wnc1_wnc3_sa104"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: cFos, FosB, Fra1 and Fra2 bind to AP-1 regulatory elements PMID:11402342 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: FBJ murine osteosarcoma viral oncogene homolog "v-fos FBJ murine osteosarcoma viral oncogene homolog" HUGO:FOS HGNC:3796 ENTREZ:2353 UNIPROT:P01100 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: c-FOS is activated by ERK and RSK through phosphorylation. PMID:16393692 References_end Identifiers_begin: FBJ murine osteosarcoma viral oncogene homolog "v-fos FBJ murine osteosarcoma viral oncogene homolog" HUGO:FOS HGNC:3796 ENTREZ:2353 UNIPROT:P01100 GENECARDS:FOS REACTOME:54964 KEGG:2353 ATLASONC:GC_FOS WIKI:FOS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: c-FOS is activated by ERK and RSK through phosphorylation. PMID:16393692 References_end</body> </html> </notes> <label text="FOS"/> <clone/> <bbox w="80.0" h="40.0" x="8668.0" y="3595.5"/> <glyph class="state variable" id="_0c4b7585-dab0-4119-8f93-c8c2fb03c698"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8663.0" y="3610.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wnc1_wnc3_s126_wnc1_wnc3_sa105"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: This is not a gene but used to indicate binding DNA sequence for AP-1 transcription factor References_end</body> </html> </notes> <label text="AP-1_ARRE binding sites*"/> <clone/> <bbox w="167.0" h="22.0" x="8582.0" y="3571.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s127_wnc1_wnc3_sa106"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <clone/> <bbox w="80.0" h="40.0" x="8625.5" y="3528.5"/> <glyph class="state variable" id="_872b106c-c14a-4b27-9971-cd9a0de8250f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8700.5" y="3551.7842"/> </glyph> <glyph class="state variable" id="_71ae00b1-f366-46f3-bee9-bb4ffffc163f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8700.5" y="3563.5"/> </glyph> <glyph class="state variable" id="_56b7a87e-5570-43e8-8466-5cc7d2d8a37c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8677.068" y="3563.5"/> </glyph> <glyph class="state variable" id="_d4c56366-cd26-4786-88f8-5610fb1f0c2a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8620.5" y="3523.5"/> </glyph> <glyph class="state variable" id="_535a79ed-ff09-48d4-a0ad-e84bed1c72d7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8643.932" y="3523.5"/> </glyph> <glyph class="state variable" id="_b4eebf6b-3e58-44d2-8fb4-2d0debb1a4dd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8660.5" y="3523.5"/> </glyph> <glyph class="state variable" id="_dbe29193-acca-47ce-b1b1-914fb2e7b158"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8620.5" y="3543.5"/> </glyph> <glyph class="state variable" id="_fbcf5236-b98a-4a7b-89f4-bdfef726bb6f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8677.068" y="3523.5"/> </glyph> <glyph class="state variable" id="_19e84ca1-4d1f-42be-82c6-3eeb26346469"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8700.5" y="3523.5"/> </glyph> <glyph class="state variable" id="_6c59eb0a-7a45-4c6e-a457-6cfb79734a71"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8700.5" y="3535.2158"/> </glyph> <glyph class="state variable" id="_625431a9-8309-479f-a354-ef62a8c0434c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8700.5" y="3543.5"/> </glyph> <glyph class="state variable" id="_527d603d-d459-4e66-a567-0b2d7ff7a1e6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8620.5" y="3523.5"/> </glyph> <glyph class="state variable" id="_0c825f76-37fa-417c-8682-2ad4da9c9156"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8620.5" y="3535.2158"/> </glyph> <glyph class="state variable" id="_9bc9d867-2b32-4a0d-84c5-b0e2e3be7324"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8620.5" y="3551.7842"/> </glyph> <glyph class="state variable" id="_14fc71c5-118d-47ca-a1d5-2345261520d5"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="8624.156" y="3563.5"/> </glyph> <glyph class="state variable" id="_0c775e4a-1b4a-4aed-8167-f546d7cf6567"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="8644.356" y="3563.5"/> </glyph> <glyph class="state variable" id="_5fcb3917-9ee6-4e1b-87d6-c65a2bd31295"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8660.5" y="3563.5"/> </glyph> <glyph class="state variable" id="_6fd12112-0686-483e-a2f3-4bde1bc76de6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8643.932" y="3563.5"/> </glyph> <glyph class="state variable" id="_8c4df012-a93c-44e5-a264-a6eeca5a8d60"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8620.5" y="3563.5"/> </glyph> <glyph class="state variable" id="_56e02eee-c812-4c77-84af-83459a9849ae"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8620.5" y="3543.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc3_s128_wnc1_wnc3_csa2" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NF-_kappa_B:NFAT* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Dimer formation with homomers of NFAT. PMID:11402342 References_end</body> </html> </notes> <label text="(NFAT/NF-kB)"/> <bbox w="179.0" h="94.0" x="7818.0" y="3621.0"/> <glyph class="macromolecule" id="wnc1_wnc3_s129_wnc1_wnc3_sa16"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="7824.0" y="3628.0"/> <glyph class="state variable" id="_0801f3f3-7618-42e0-8ac7-1a0ba0e54fe5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7899.0" y="3651.2842"/> </glyph> <glyph class="state variable" id="_82b81093-00d4-4e57-9844-bff4616ef545"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7899.0" y="3663.0"/> </glyph> <glyph class="state variable" id="_b10dd981-d6f5-4e71-9147-7b7c2215013b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7875.5684" y="3663.0"/> </glyph> <glyph class="state variable" id="_5280cab4-0bb5-40d8-8ca3-8b19e55ad781"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7819.0" y="3623.0"/> </glyph> <glyph class="state variable" id="_b8d6c69d-6218-489c-9358-ad6baa2b6c30"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7842.4316" y="3623.0"/> </glyph> <glyph class="state variable" id="_64463739-67d5-4866-9b08-152f208ab305"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7859.0" y="3623.0"/> </glyph> <glyph class="state variable" id="_848ab647-2f2e-4176-aef6-d874332ab61f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7819.0" y="3643.0"/> </glyph> <glyph class="state variable" id="_d36e5c5b-18c0-4319-a81e-e47a455bd425"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7875.5684" y="3623.0"/> </glyph> <glyph class="state variable" id="_82577280-73db-4a4a-a3c1-03aaf6837695"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7899.0" y="3623.0"/> </glyph> <glyph class="state variable" id="_6b5f2472-3d0c-4f2e-a007-dffeaefbdc26"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7899.0" y="3634.7158"/> </glyph> <glyph class="state variable" id="_d77261ad-f864-47f5-91c0-370b44c378bb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7899.0" y="3643.0"/> </glyph> <glyph class="state variable" id="_1fdcb76b-268d-4a70-8e32-a0a5056954a2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7819.0" y="3623.0"/> </glyph> <glyph class="state variable" id="_8ea44b68-bb40-427b-9770-20ddfd3fed9f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7819.0" y="3634.7158"/> </glyph> <glyph class="state variable" id="_3384ed19-48c0-4177-a1a9-7cc2563574d0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7819.0" y="3651.2842"/> </glyph> <glyph class="state variable" id="_e0ca14d7-4df6-43d1-96c1-43d855246a3b"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="7822.6562" y="3663.0"/> </glyph> <glyph class="state variable" id="_19049444-6924-4bd3-9a16-83db9e095533"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="7842.857" y="3663.0"/> </glyph> <glyph class="state variable" id="_f554f9d3-b832-4d27-8c60-a6885b08e704"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7859.0" y="3663.0"/> </glyph> <glyph class="state variable" id="_b6801848-bec0-4aaf-934f-6a27271448e0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7842.4316" y="3663.0"/> </glyph> <glyph class="state variable" id="_0f76dfb5-c5fb-4744-bfc9-51f2c78cb1f8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7819.0" y="3663.0"/> </glyph> <glyph class="state variable" id="_2db05db0-564b-45cb-8d12-5f3edabec4bb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7819.0" y="3643.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s129_wnc1_wnc3_sa17"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="7907.5" y="3628.0"/> <glyph class="state variable" id="_a10abb5f-e1b7-4f6a-a7f9-66722254c964"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7982.5" y="3651.2842"/> </glyph> <glyph class="state variable" id="_e49dec8d-6e61-45cc-b758-0752e0733916"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7982.5" y="3663.0"/> </glyph> <glyph class="state variable" id="_52740242-cfcf-4fef-8ace-e62eddc2f055"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7959.0684" y="3663.0"/> </glyph> <glyph class="state variable" id="_5c67edd2-8e05-4f7d-8f8d-669c5a043874"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7902.5" y="3623.0"/> </glyph> <glyph class="state variable" id="_4ab7dabc-993f-439a-88b8-776c3a18d976"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7925.9316" y="3623.0"/> </glyph> <glyph class="state variable" id="_44d01fb1-011a-4195-8be3-126785cda6eb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7942.5" y="3623.0"/> </glyph> <glyph class="state variable" id="_91595dca-3c15-4adc-927d-eea218b6a5cc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7902.5" y="3643.0"/> </glyph> <glyph class="state variable" id="_a224833c-1b2d-453b-aaff-9ea2d2d86749"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7959.0684" y="3623.0"/> </glyph> <glyph class="state variable" id="_9238e00b-2446-4d2f-a21e-aeff9986113a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7982.5" y="3623.0"/> </glyph> <glyph class="state variable" id="_a6389b91-42bc-479a-9f31-0d3347bf8398"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7982.5" y="3634.7158"/> </glyph> <glyph class="state variable" id="_12a148aa-87cf-4e76-a017-59fd0d030919"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7982.5" y="3643.0"/> </glyph> <glyph class="state variable" id="_fcc58481-2d2a-429e-8c09-13869ed8517a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7902.5" y="3623.0"/> </glyph> <glyph class="state variable" id="_7b0eef8c-6b94-4b42-8c97-3f4063dc29ba"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7902.5" y="3634.7158"/> </glyph> <glyph class="state variable" id="_9a2e788e-99d3-4144-8f73-2fba5ca2f530"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7902.5" y="3651.2842"/> </glyph> <glyph class="state variable" id="_18487b78-4b9c-4b40-9e07-e8734a9e5e93"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="7906.1562" y="3663.0"/> </glyph> <glyph class="state variable" id="_e001c472-400b-40f7-8db4-33e963ea7279"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="7926.357" y="3663.0"/> </glyph> <glyph class="state variable" id="_42d3910e-6a37-46b1-9f65-4caa0d24b3ca"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7942.5" y="3663.0"/> </glyph> <glyph class="state variable" id="_efb11822-3b08-43f8-8879-31bd24ac56ab"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7925.9316" y="3663.0"/> </glyph> <glyph class="state variable" id="_10be739a-ca3a-47d2-b00e-5399f820b971"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7902.5" y="3663.0"/> </glyph> <glyph class="state variable" id="_f897d455-ac8b-4b4a-98b9-db5ee4d23dd5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="7902.5" y="3643.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wnc1_wnc3_s19_wnc1_wnc3_sa18"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: This is not a gene but used to indicate binding DNA sequence for NF-kB transcription factor References_end</body> </html> </notes> <label text="NF-κB"/> <bbox w="164.0" h="22.0" x="7824.0" y="3670.5"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc3_s130_wnc1_wnc3_csa12" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CNA*:CNB*:NFAT* Identifiers_end References_begin: s_wnc3_re29:(MAP:survival) PMID15657416 References_end</body> </html> </notes> <label text="(Calcineurin/ NFAT)"/> <bbox w="100.0" h="169.0" x="8084.0" y="3699.0"/> <glyph class="macromolecule" id="wnc1_wnc3_s99_wnc1_wnc3_sa85"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, catalytic subunit, alpha isozyme CALN, CALNA, "protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)" HUGO:PPP3CA HGNC:9314 ENTREZ:5530 UNIPROT:Q08209 GENECARDS:PPP3CA REACTOME:61110 KEGG:5530 ATLASONC:GC_PPP3CA WIKI:PPP3CA protein phosphatase 3, catalytic subunit, beta isozyme CALNB, "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)" HUGO:PPP3CB HGNC:9315 ENTREZ:5532 UNIPROT:P16298 GENECARDS:PPP3CB REACTOME:403037 KEGG:5532 ATLASONC:GC_PPP3CB WIKI:PPP3CB protein phosphatase 3, catalytic subunit, gamma isozyme "protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma)" HUGO:PPP3CC HGNC:9316 ENTREZ:5533 UNIPROT:P48454 GENECARDS:PPP3CC REACTOME:61114 KEGG:5533 ATLASONC:GC_PPP3CC WIKI:PPP3CC Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CNA*"/> <bbox w="80.0" h="40.0" x="8093.0" y="3706.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s100_wnc1_wnc3_sa86"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, regulatory subunit B, alpha "protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform" HUGO:PPP3R1 HGNC:9317 ENTREZ:5534 UNIPROT:P63098 GENECARDS:PPP3R1 REACTOME:51292 KEGG:5534 ATLASONC:GC_PPP3R1 WIKI:PPP3R1 protein phosphatase 3, regulatory subunit B, beta HUGO:PPP3PR2 GENECARDS:PPP3PR2 WIKI:PPP3PR2 HUGO:PPP3R2 HGNC:9318 ENTREZ:5535 UNIPROT:Q96LZ3 GENECARDS:PPP3R2 KEGG:5535 ATLASONC:GC_PPP3R2 WIKI:PPP3R2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CNB*"/> <bbox w="80.0" h="40.0" x="8093.0" y="3749.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s102_wnc1_wnc3_sa87"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="8093.0" y="3791.0"/> <glyph class="state variable" id="_1dfea34f-bb0a-4b52-8b18-d6e1ed550c76"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8168.0" y="3814.2842"/> </glyph> <glyph class="state variable" id="_2565d255-9f09-47fc-b1cc-72bf8e0216f0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8168.0" y="3826.0"/> </glyph> <glyph class="state variable" id="_14c9590b-1ec6-4ef7-b4eb-fba636464a66"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8144.5684" y="3826.0"/> </glyph> <glyph class="state variable" id="_bf282e08-fbfb-44b7-9187-422a65129cac"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8088.0" y="3786.0"/> </glyph> <glyph class="state variable" id="_84a0bf04-5c78-40fe-932e-f850bbcc059e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8111.4316" y="3786.0"/> </glyph> <glyph class="state variable" id="_eb67c6f5-0498-450f-98a6-06004e563a77"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8128.0" y="3786.0"/> </glyph> <glyph class="state variable" id="_994b9a48-82dc-4c5b-bffd-cd1323986e44"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8088.0" y="3806.0"/> </glyph> <glyph class="state variable" id="_9d5ae5b5-e0b8-4385-9adc-c44cca5fb9a7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8144.5684" y="3786.0"/> </glyph> <glyph class="state variable" id="_47a76b36-7dd5-469a-aa12-135dbfe3f0c0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8168.0" y="3786.0"/> </glyph> <glyph class="state variable" id="_f031d7fc-306e-4eb6-83ee-8d8db9f6d690"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8168.0" y="3797.7158"/> </glyph> <glyph class="state variable" id="_26d7d6f4-88b5-49a5-a9fa-96279794d086"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8168.0" y="3806.0"/> </glyph> <glyph class="state variable" id="_ef8c9cc7-132c-4d33-8caa-9b788267fe86"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8088.0" y="3786.0"/> </glyph> <glyph class="state variable" id="_dc6aa3dc-1890-4b37-8b11-809981a766e9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8088.0" y="3797.7158"/> </glyph> <glyph class="state variable" id="_4e7de2ba-c55c-4ed9-b785-65acb1a1bdf5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8088.0" y="3814.2842"/> </glyph> <glyph class="state variable" id="_54b231d3-81de-4a37-85c1-d1c69191041d"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="8091.6562" y="3826.0"/> </glyph> <glyph class="state variable" id="_16190e5b-c8c2-4100-93f3-3a8ff078dad4"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="8111.857" y="3826.0"/> </glyph> <glyph class="state variable" id="_3aa7e265-d5bf-41ac-85eb-cc96a81818be"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8128.0" y="3826.0"/> </glyph> <glyph class="state variable" id="_8ae0653c-1e57-4608-8941-ef7f678a786d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8111.4316" y="3826.0"/> </glyph> <glyph class="state variable" id="_9b3d3f2b-cc4a-4ade-bcd6-4f8fce3ea8b2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8088.0" y="3826.0"/> </glyph> <glyph class="state variable" id="_3840022e-9daa-4279-adbf-b324ebfcffa0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8088.0" y="3806.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc3_s131_wnc1_wnc3_csa13" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CNA*:CNB* Identifiers_end References_begin: s_wnc3_re31(MAP:survival): Phosphorylation of NFAT leads to increased DNA binding of NFAT -> increased gene transcription PMID15657416 Not sure if dissociation of calcineurin and ERK/MEK occurs References_end</body> </html> </notes> <label text="(Calcineurin)"/> <bbox w="96.0" h="113.0" x="8086.0" y="3916.5"/> <glyph class="macromolecule" id="wnc1_wnc3_s105_wnc1_wnc3_sa88"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, catalytic subunit, alpha isozyme CALN, CALNA, "protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)" HUGO:PPP3CA HGNC:9314 ENTREZ:5530 UNIPROT:Q08209 GENECARDS:PPP3CA REACTOME:61110 KEGG:5530 ATLASONC:GC_PPP3CA WIKI:PPP3CA protein phosphatase 3, catalytic subunit, beta isozyme CALNB, "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)" HUGO:PPP3CB HGNC:9315 ENTREZ:5532 UNIPROT:P16298 GENECARDS:PPP3CB REACTOME:403037 KEGG:5532 ATLASONC:GC_PPP3CB WIKI:PPP3CB protein phosphatase 3, catalytic subunit, gamma isozyme "protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma)" HUGO:PPP3CC HGNC:9316 ENTREZ:5533 UNIPROT:P48454 GENECARDS:PPP3CC REACTOME:61114 KEGG:5533 ATLASONC:GC_PPP3CC WIKI:PPP3CC Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CNA*"/> <bbox w="80.0" h="40.0" x="8095.0" y="3923.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s106_wnc1_wnc3_sa89"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, regulatory subunit B, alpha "protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform" HUGO:PPP3R1 HGNC:9317 ENTREZ:5534 UNIPROT:P63098 GENECARDS:PPP3R1 REACTOME:51292 KEGG:5534 ATLASONC:GC_PPP3R1 WIKI:PPP3R1 protein phosphatase 3, regulatory subunit B, beta HUGO:PPP3PR2 GENECARDS:PPP3PR2 WIKI:PPP3PR2 HUGO:PPP3R2 HGNC:9318 ENTREZ:5535 UNIPROT:Q96LZ3 GENECARDS:PPP3R2 KEGG:5535 ATLASONC:GC_PPP3R2 WIKI:PPP3R2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CNB*"/> <bbox w="80.0" h="40.0" x="8095.0" y="3966.5"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc3_s132_wnc1_wnc3_csa15" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CNA*:CNB*:ERK2*:MEK1*:NFAT* Identifiers_end References_begin: s_wnc3_re30(MAP:survival): CnA binds to MEK1, MEK1 binds to ERK2 and ERK2 phosphorylates NFAT PMID15657416 s_wnc3_re31(MAP:survival): Phosphorylation of NFAT leads to increased DNA binding of NFAT -> increased gene transcription Not sure if dissociation of calcineurin and ERK/MEK occurs References_end</body> </html> </notes> <label text="(Calcineurin/NFAT/ERK2/MEK1)"/> <bbox w="184.0" h="159.0" x="8574.0" y="3704.5"/> <glyph class="macromolecule" id="wnc1_wnc3_s118_wnc1_wnc3_sa98"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, catalytic subunit, alpha isozyme CALN, CALNA, "protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)" HUGO:PPP3CA HGNC:9314 ENTREZ:5530 UNIPROT:Q08209 GENECARDS:PPP3CA REACTOME:61110 KEGG:5530 ATLASONC:GC_PPP3CA WIKI:PPP3CA protein phosphatase 3, catalytic subunit, beta isozyme CALNB, "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)" HUGO:PPP3CB HGNC:9315 ENTREZ:5532 UNIPROT:P16298 GENECARDS:PPP3CB REACTOME:403037 KEGG:5532 ATLASONC:GC_PPP3CB WIKI:PPP3CB protein phosphatase 3, catalytic subunit, gamma isozyme "protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma)" HUGO:PPP3CC HGNC:9316 ENTREZ:5533 UNIPROT:P48454 GENECARDS:PPP3CC REACTOME:61114 KEGG:5533 ATLASONC:GC_PPP3CC WIKI:PPP3CC Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CNA*"/> <bbox w="80.0" h="40.0" x="8583.0" y="3711.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s119_wnc1_wnc3_sa99"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, regulatory subunit B, alpha "protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform" HUGO:PPP3R1 HGNC:9317 ENTREZ:5534 UNIPROT:P63098 GENECARDS:PPP3R1 REACTOME:51292 KEGG:5534 ATLASONC:GC_PPP3R1 WIKI:PPP3R1 protein phosphatase 3, regulatory subunit B, beta HUGO:PPP3PR2 GENECARDS:PPP3PR2 WIKI:PPP3PR2 HUGO:PPP3R2 HGNC:9318 ENTREZ:5535 UNIPROT:Q96LZ3 GENECARDS:PPP3R2 KEGG:5535 ATLASONC:GC_PPP3R2 WIKI:PPP3R2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CNB*"/> <bbox w="80.0" h="40.0" x="8583.0" y="3754.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s122_wnc1_wnc3_sa100"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="8583.0" y="3796.5"/> <glyph class="state variable" id="_534c6893-c965-42cd-993f-519a8e46cc50"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8658.0" y="3819.7842"/> </glyph> <glyph class="state variable" id="_2c00ef0f-e469-4eb6-9263-6ace3b1d28b1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8658.0" y="3831.5"/> </glyph> <glyph class="state variable" id="_7d8eb49a-6aba-4021-a4eb-f49a62d88b23"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8634.568" y="3831.5"/> </glyph> <glyph class="state variable" id="_45f74ff6-37c2-463a-bf32-e1fb5844df85"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8578.0" y="3791.5"/> </glyph> <glyph class="state variable" id="_a3a130ba-3ab5-460e-aa4b-1efca30754a9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8601.432" y="3791.5"/> </glyph> <glyph class="state variable" id="_ac2d6930-b602-4133-9417-a3b3c535103d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8618.0" y="3791.5"/> </glyph> <glyph class="state variable" id="_ec22d3d7-787b-473a-b253-a26d254a749c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8578.0" y="3811.5"/> </glyph> <glyph class="state variable" id="_055775bd-1fa7-4882-8564-ac5115f4b2cb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8634.568" y="3791.5"/> </glyph> <glyph class="state variable" id="_d0f39a29-3e4a-4195-b695-f9edd1e0c0dc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8658.0" y="3791.5"/> </glyph> <glyph class="state variable" id="_1bbb4402-9198-4022-a75b-88d19b4463e0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8658.0" y="3803.2158"/> </glyph> <glyph class="state variable" id="_a0e32011-7f85-4d91-aec5-8b9a75ca7b93"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8658.0" y="3811.5"/> </glyph> <glyph class="state variable" id="_14abec76-555b-46bd-8c6d-dc867d04a9c4"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="8575.5" y="3791.5"/> </glyph> <glyph class="state variable" id="_39d3c017-e8be-422e-9fb6-53c710e9bc30"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8578.0" y="3803.2158"/> </glyph> <glyph class="state variable" id="_f5b4c56c-c18a-4680-9750-6ebb8d9020f1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8578.0" y="3819.7842"/> </glyph> <glyph class="state variable" id="_e91a6ad7-91da-4663-b93c-a74d0ac6b9aa"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="8581.656" y="3831.5"/> </glyph> <glyph class="state variable" id="_a82b89d9-3cae-4934-8526-074eb5920213"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="8601.856" y="3831.5"/> </glyph> <glyph class="state variable" id="_2ed61b6e-b47f-412c-9540-71eb8ebe862d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8618.0" y="3831.5"/> </glyph> <glyph class="state variable" id="_7d5cb25c-e8b5-4e63-bf28-b37e7b45a7e4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8601.432" y="3831.5"/> </glyph> <glyph class="state variable" id="_53a42114-159b-447d-8786-402798233011"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8578.0" y="3831.5"/> </glyph> <glyph class="state variable" id="_8228e344-ff84-4e92-9326-7a4f6bb2885e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8578.0" y="3811.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s120_wnc1_wnc3_sa101"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase 1 PRKM1, PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1 REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ERK2*"/> <bbox w="80.0" h="40.0" x="8666.0" y="3711.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s121_wnc1_wnc3_sa102"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 1 PRKMK1 HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 GENECARDS:MAP2K1 REACTOME:59503 KEGG:5604 ATLASONC:GC_MAP2K1 WIKI:MAP2K1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MEK1*"/> <bbox w="80.0" h="40.0" x="8666.0" y="3754.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc3_s133_wnc1_wnc3_csa14" compartmentRef="wnc1_wnc3_c2_wnc1_wnc3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CNA*:CNB*:ERK2*:MEK1*:NFAT* Identifiers_end References_begin: s_wnc3_re29:(MAP:survival) PMID15657416 s_wnc3_re30(MAP:survival): CnA binds to MEK1, MEK1 binds to ERK2 and ERK2 phosphorylates NFAT PMID15657416 References_end</body> </html> </notes> <label text="(Calcineurin/NFAT/ERK2/MEK1)"/> <bbox w="184.0" h="159.0" x="8302.0" y="3704.5"/> <glyph class="macromolecule" id="wnc1_wnc3_s111_wnc1_wnc3_sa93"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, catalytic subunit, alpha isozyme CALN, CALNA, "protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)" HUGO:PPP3CA HGNC:9314 ENTREZ:5530 UNIPROT:Q08209 GENECARDS:PPP3CA REACTOME:61110 KEGG:5530 ATLASONC:GC_PPP3CA WIKI:PPP3CA protein phosphatase 3, catalytic subunit, beta isozyme CALNB, "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)" HUGO:PPP3CB HGNC:9315 ENTREZ:5532 UNIPROT:P16298 GENECARDS:PPP3CB REACTOME:403037 KEGG:5532 ATLASONC:GC_PPP3CB WIKI:PPP3CB protein phosphatase 3, catalytic subunit, gamma isozyme "protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform", "protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma)" HUGO:PPP3CC HGNC:9316 ENTREZ:5533 UNIPROT:P48454 GENECARDS:PPP3CC REACTOME:61114 KEGG:5533 ATLASONC:GC_PPP3CC WIKI:PPP3CC Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CNA*"/> <bbox w="80.0" h="40.0" x="8311.0" y="3711.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s112_wnc1_wnc3_sa94"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 3, regulatory subunit B, alpha "protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I)", "protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform" HUGO:PPP3R1 HGNC:9317 ENTREZ:5534 UNIPROT:P63098 GENECARDS:PPP3R1 REACTOME:51292 KEGG:5534 ATLASONC:GC_PPP3R1 WIKI:PPP3R1 protein phosphatase 3, regulatory subunit B, beta HUGO:PPP3PR2 GENECARDS:PPP3PR2 WIKI:PPP3PR2 HUGO:PPP3R2 HGNC:9318 ENTREZ:5535 UNIPROT:Q96LZ3 GENECARDS:PPP3R2 KEGG:5535 ATLASONC:GC_PPP3R2 WIKI:PPP3R2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CNB*"/> <bbox w="80.0" h="40.0" x="8311.0" y="3754.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s113_wnc1_wnc3_sa95"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 References_end Identifiers_begin: nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 1 HUGO:NFATC1 HGNC:7775 ENTREZ:4772 UNIPROT:O95644 GENECARDS:NFATC1 REACTOME:60119 KEGG:4772 ATLASONC:GC_NFATC1 WIKI:NFATC1 nuclear factor of activated T-cells cytoplasmic calcineurin-dependent 3 HUGO:NFATC3 HGNC:7777 ENTREZ:4775 UNIPROT:Q12968 GENECARDS:NFATC3 REACTOME:60123 KEGG:4775 ATLASONC:GC_NFATC3 WIKI:NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 NF-ATP, NFAT1, NFATp HUGO:NFATC2 HGNC:7776 ENTREZ:4773 UNIPROT:Q13469 GENECARDS:NFATC2 REACTOME:60121 KEGG:4773 ATLASONC:NFATC2ID44004ch20q13 WIKI:NFATC2 NF-ATC, NFAT2, NFATc nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 NFAT3 HUGO:NFATC4 HGNC:7778 ENTREZ:4776 UNIPROT:Q14934 GENECARDS:NFATC4 KEGG:4776 ATLASONC:GC_NFATC4 WIKI:NFATC4 UNIIPROT:Q149934 nuclear factor of activated T-cells 5, tonicity-responsive NFAT5 HUGO:NFAT5 HGNC:7774 ENTREZ:10725 UNIPROT:O94916 GENECARDS:NFAT5 KEGG:10725 ATLASONC:GC_NFAT5 WIKI:NFAT5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT sites are often located close to AP-1 sites in many promoters allowing for cooperative binding and synergistic trans-activation of numerous genes. NFATc1 is crucial to the differentiation of Th cells to the Th2 effector phenotype. PMID:11274345 NFAT1 has at least 21 phosphorylation sites, 18 are located within the regulatory domain, 14 are conserved in the NFAT family 13 are dephosphorylated upon stimulation which is required to cause full exposure of NLS, mask an NES, needed for full activation: 7 serine residues in SRR1 domain of which 5 are phosphorylated (S170, S173, S174, S176, S177, S179, and S182), S215, S219, S223, S238, S245, S270, S276, S278, S282, and S2328. PMID:11030334 NFAT5 activity is not regulated by phosphorylation but osmotic stress PMID:11402342 References_end</body> </html> </notes> <label text="NFAT*"/> <bbox w="80.0" h="40.0" x="8311.0" y="3796.5"/> <glyph class="state variable" id="_4fb4a025-7e47-48e2-a493-ba9526454982"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8386.0" y="3819.7842"/> </glyph> <glyph class="state variable" id="_61809c58-f9b2-4838-9184-3b3f4fe2d942"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8386.0" y="3831.5"/> </glyph> <glyph class="state variable" id="_424da683-dd71-4665-aa75-1a2691fd273f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8362.568" y="3831.5"/> </glyph> <glyph class="state variable" id="_770dc4c6-6190-4b20-9617-34c8c4e1ccb1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8306.0" y="3791.5"/> </glyph> <glyph class="state variable" id="_39952480-96a7-49a1-a395-1bd93ee001ae"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8329.432" y="3791.5"/> </glyph> <glyph class="state variable" id="_00141f34-3463-470c-b964-67bd09c0257d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8346.0" y="3791.5"/> </glyph> <glyph class="state variable" id="_1e7a982a-a2b9-4d7e-bbbe-5779b424c5ae"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8306.0" y="3811.5"/> </glyph> <glyph class="state variable" id="_c7ef8ad4-fe72-4029-bfbd-b782ef616f99"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8362.568" y="3791.5"/> </glyph> <glyph class="state variable" id="_f8ff32af-026d-4ac3-9eff-e7254fa77150"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8386.0" y="3791.5"/> </glyph> <glyph class="state variable" id="_f84f5a1b-5db1-4c3c-b2d4-3f5a930913ca"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8386.0" y="3803.2158"/> </glyph> <glyph class="state variable" id="_f3bf5af0-e089-476c-a856-040b1d533c0f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8386.0" y="3811.5"/> </glyph> <glyph class="state variable" id="_44ad5836-373c-4c23-ab96-4bba0135a147"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8306.0" y="3791.5"/> </glyph> <glyph class="state variable" id="_0d1d8028-57b2-4efa-816f-45da88e03cfb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8306.0" y="3803.2158"/> </glyph> <glyph class="state variable" id="_216113f8-0cff-43ba-9b8a-7e3b61b44e89"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8306.0" y="3819.7842"/> </glyph> <glyph class="state variable" id="_8d3da3e2-59db-4675-a6ef-baaa0c9b6394"> <state value="" variable="S289"/> <bbox w="30.0" h="10.0" x="8309.656" y="3831.5"/> </glyph> <glyph class="state variable" id="_ba8a6f55-c91e-4d4a-b04b-8736dca4b812"> <state value="" variable="S272"/> <bbox w="30.0" h="10.0" x="8329.856" y="3831.5"/> </glyph> <glyph class="state variable" id="_ba11f26f-6221-4ead-80ab-31be3ed57ca4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8346.0" y="3831.5"/> </glyph> <glyph class="state variable" id="_87bd6d64-0fa5-47b3-98b5-10d5723974b4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8329.432" y="3831.5"/> </glyph> <glyph class="state variable" id="_a3047dc6-32ef-4bd0-ab14-7ac11b6c661b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8306.0" y="3831.5"/> </glyph> <glyph class="state variable" id="_29e40901-afc4-4fe2-a567-1502d4476ff7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="8306.0" y="3811.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s114_wnc1_wnc3_sa96"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase 1 PRKM1, PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1 REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ERK2*"/> <bbox w="80.0" h="40.0" x="8394.0" y="3711.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc3_s115_wnc1_wnc3_sa97"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mitogen-activated protein kinase kinase 1 PRKMK1 HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 GENECARDS:MAP2K1 REACTOME:59503 KEGG:5604 ATLASONC:GC_MAP2K1 WIKI:MAP2K1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MEK1*"/> <bbox w="80.0" h="40.0" x="8394.0" y="3754.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc4_s8_wnc1_wnc4_csa1" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FGF2:RTK* Identifiers_end References_begin: s_wnc4_re4:(MAP:survival) PMID:22558232 References_end</body> </html> </notes> <label text="FGF2:RTK*"/> <bbox w="100.0" h="120.0" x="9978.0" y="2943.0"/> <glyph class="macromolecule" id="wnc1_wnc4_s10_wnc1_wnc4_sa1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> </notes> <label text="RTK*"/> <bbox w="80.0" h="50.0" x="9989.0" y="2992.0"/> <glyph class="state variable" id="_21deb482-7e65-48e4-92db-7643249e525a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10064.0" y="3022.3552"/> </glyph> <glyph class="state variable" id="_b44f547c-7d50-4498-99c4-6715df341db2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10064.0" y="3022.3552"/> </glyph> <glyph class="state variable" id="_d5ef4307-f344-43f8-9b81-fba28a86a887"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10064.0" y="3012.0"/> </glyph> <glyph class="unit of information" id="_75b684fa-1d41-4f52-b3e0-025557c393f0"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="10006.5" y="2987.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s9_wnc1_wnc4_sa7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: fibroblast growth factor 2 (basic) FGFB HUGO:FGF2 HGNC:3676 ENTREZ:2247 UNIPROT:P09038 GENECARDS:FGF2 REACTOME:54764 KEGG:2247 ATLASONC:FGF2ID511ch4q27 WIKI:FGF2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:ECM MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="FGF2"/> <bbox w="80.0" h="40.0" x="9989.0" y="2951.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc4_s48_wnc1_wnc4_csa5" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AXIN*:HIPK2:p53* Identifiers_end References_begin: s_wnc4_re8:(MAP:survival) PMID:15526030 References_end</body> </html> </notes> <label text="AXIN*:HIPK2:p53*"/> <bbox w="99.0" h="160.0" x="10910.0" y="3986.0"/> <glyph class="macromolecule" id="wnc1_wnc4_s51_wnc1_wnc4_sa30"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin Axin acts here mainly as scaffold protein PMID:15526030 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="10921.0" y="3995.0"/> <glyph class="state variable" id="_2e2cf7fa-d6a3-4b1b-b696-171afcdbc903"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="10908.992" y="3990.0"/> </glyph> <glyph class="state variable" id="_cbb29f4b-8be4-4bc6-a40a-fd12a3a8aa59"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="10948.532" y="3990.0"/> </glyph> <glyph class="state variable" id="_e7f21444-53c6-4767-b4c9-8b8399cbec33"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="10986.0" y="3990.2148"/> </glyph> <glyph class="state variable" id="_5ff0604c-4797-4b98-888a-d6e4c7fad049"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="10985.382" y="4030.0"/> </glyph> <glyph class="state variable" id="_e1029c83-94f4-4512-9ff4-b81f2683a787"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="10945.904" y="4030.0"/> </glyph> <glyph class="state variable" id="_be27b051-6d62-4e2e-9f03-184cfbb0c490"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="10906.0" y="4029.7224"/> </glyph> <glyph class="state variable" id="_531ae1da-2ef4-45cd-84fd-5eefe9cfa82a"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="10948.404" y="4030.0"/> </glyph> <glyph class="state variable" id="_6f756d57-e17d-41bf-8614-c989fbc260fc"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="10987.882" y="4030.0"/> </glyph> <glyph class="state variable" id="_34c037d6-bcdd-42fb-ab5b-b066a7af35d9"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="10993.5" y="3990.2148"/> </glyph> <glyph class="state variable" id="_1837f256-a955-4141-adf4-42fe071910d1"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="10908.5" y="4029.7224"/> </glyph> <glyph class="state variable" id="_1a2d7ef4-7853-4228-9f5e-7516ecc05d9e"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="10913.992" y="3990.0"/> </glyph> <glyph class="state variable" id="_9ae952ba-2da7-4f52-970d-191e30094a46"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10916.0" y="3990.0"/> </glyph> <glyph class="state variable" id="_d170c15a-e79a-4c3c-85ac-ed3490a6c1df"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10996.0" y="3990.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s49_wnc1_wnc4_sa31"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 References_end Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end</body> </html> Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end</body> </html> Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end</body> </html> </notes> <label text="p53*"/> <bbox w="80.0" h="40.0" x="10921.0" y="4038.0"/> <glyph class="state variable" id="_f73d1b6e-df09-48d4-b1a6-0ad1e42e309c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10996.0" y="4073.0"/> </glyph> <glyph class="state variable" id="_bc3a87cd-c2bc-4309-a763-4689d12724f2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10916.0" y="4033.0"/> </glyph> <glyph class="state variable" id="_13967fc8-d1f6-49dd-b7c0-9e045dfaaaf0"> <state value="" variable="S46"/> <bbox w="25.0" h="10.0" x="10988.5" y="4033.2148"/> </glyph> <glyph class="state variable" id="_d80e96ff-8758-4bdb-9537-328b58465882"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10916.0" y="4053.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s50_wnc1_wnc4_sa32"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: homeodomain interacting protein kinase 2 "homeodomain-interacting protein kinase 2" HUGO:HIPK2 HGNC:14402 ENTREZ:28996 UNIPROT:Q9H2X6 GENECARDS:HIPK2 KEGG:28996 ATLASONC:HIPK2ID40824ch7q34 WIKI:HIPK2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: HIPK2 is pre-dominantly present in the nucleus PMID:18974774 References_end Identifiers_begin: homeodomain interacting protein kinase 2 "homeodomain-interacting protein kinase 2" HUGO:HIPK2 HGNC:14402 ENTREZ:28996 UNIPROT:Q9H2X6 GENECARDS:HIPK2 KEGG:28996 ATLASONC:HIPK2ID40824ch7q34 WIKI:HIPK2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: HIPK2 is pre-dominantly present in the nucleus PMID:18974774 References_end</body> </html> </notes> <label text="HIPK2"/> <bbox w="80.0" h="40.0" x="10921.0" y="4081.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc4_s52_wnc1_wnc4_csa6" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AXIN*:HIPK2:p53* Identifiers_end References_begin: s_wnc4_re9:(MAP:survival) PMID:15526030 s_wnc4_re11(MAP:survival): Increased transcription of p53-target genes PMID:15526030 References_end</body> </html> </notes> <label text="AXIN*:HIPK2:p53*"/> <bbox w="99.0" h="160.0" x="11090.0" y="3985.0"/> <glyph class="macromolecule" id="wnc1_wnc4_s53_wnc1_wnc4_sa33"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="11101.0" y="3994.0"/> <glyph class="state variable" id="_a17e5cba-104a-4a9e-bcb1-1413e51df6d1"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="11088.992" y="3989.0"/> </glyph> <glyph class="state variable" id="_9f3d739d-e151-4c61-97ff-8ded27284302"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="11128.532" y="3989.0"/> </glyph> <glyph class="state variable" id="_310a05b8-7049-40c9-a220-432f76786e5c"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="11166.0" y="3989.2148"/> </glyph> <glyph class="state variable" id="_61cfc6ca-6326-4eb6-baad-dfec0ca9e808"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="11165.382" y="4029.0"/> </glyph> <glyph class="state variable" id="_f7f6ccd9-6915-4401-a974-8a73693149cb"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="11125.904" y="4029.0"/> </glyph> <glyph class="state variable" id="_281d6e9b-4ba1-4154-9018-b2975af91e2c"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="11086.0" y="4028.7224"/> </glyph> <glyph class="state variable" id="_65ae0490-6513-4fc5-92f0-e22a11065fb6"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="11128.404" y="4029.0"/> </glyph> <glyph class="state variable" id="_44ea59dc-2a7c-4f15-badf-d488aa113d83"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="11167.882" y="4029.0"/> </glyph> <glyph class="state variable" id="_aa74058b-e336-48fd-9f92-7b617dd171a4"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="11173.5" y="3989.2148"/> </glyph> <glyph class="state variable" id="_6c43cba6-34dd-4e4e-815d-8e0948927a30"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="11088.5" y="4028.7224"/> </glyph> <glyph class="state variable" id="_37f1a750-b82c-4f94-9441-90016c5cfc34"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="11093.992" y="3989.0"/> </glyph> <glyph class="state variable" id="_d87c61c2-8499-4566-ab91-063b56b81048"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11096.0" y="3989.0"/> </glyph> <glyph class="state variable" id="_2ef7e1dd-0fcc-4fbd-9867-ec87374e22f9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11176.0" y="3989.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s55_wnc1_wnc4_sa34"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Phosphorylation of S46 increases stability of p53 PMID:15526030 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 References_end Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end</body> </html> </notes> <label text="p53*"/> <bbox w="80.0" h="40.0" x="11101.0" y="4037.0"/> <glyph class="state variable" id="_ed13b9b9-7c88-47b7-9a10-03e0e42646a7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11176.0" y="4072.0"/> </glyph> <glyph class="state variable" id="_ee83c722-3a6b-4c7d-92e0-5c990beafac7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11096.0" y="4032.0"/> </glyph> <glyph class="state variable" id="_5f0f1b1b-a9fc-4f31-8f5f-cff3cb1ce5e3"> <state value="P" variable="S46"/> <bbox w="30.0" h="10.0" x="11166.0" y="4032.2148"/> </glyph> <glyph class="state variable" id="_3928e987-f29d-4904-af55-2ce21a9c65b7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11096.0" y="4052.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s54_wnc1_wnc4_sa35"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: homeodomain interacting protein kinase 2 "homeodomain-interacting protein kinase 2" HUGO:HIPK2 HGNC:14402 ENTREZ:28996 UNIPROT:Q9H2X6 GENECARDS:HIPK2 KEGG:28996 ATLASONC:HIPK2ID40824ch7q34 WIKI:HIPK2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: HIPK2 is pre-dominantly present in the nucleus PMID:18974774 References_end Identifiers_begin: homeodomain interacting protein kinase 2 "homeodomain-interacting protein kinase 2" HUGO:HIPK2 HGNC:14402 ENTREZ:28996 UNIPROT:Q9H2X6 GENECARDS:HIPK2 KEGG:28996 ATLASONC:HIPK2ID40824ch7q34 WIKI:HIPK2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: HIPK2 is pre-dominantly present in the nucleus PMID:18974774 References_end</body> </html> </notes> <label text="HIPK2"/> <bbox w="80.0" h="40.0" x="11101.0" y="4080.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc4_s124_wnc1_wnc4_csa11" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:G_alpha__sub_12_endsub_*:p120* Identifiers_end References_begin: s_wnc4_re29:(MAP:survival) PMID:15240885 s_wnc4_re24(MAP:survival): Complex of G-alpha12 and p120 stabilises binding of E-cadherin in Adhesion-complex. G-alpha12 is found back in complex with p120 and E-cadherin PMID:15240885 References_end</body> </html> </notes> <label text="Gα12*:p120*"/> <bbox w="100.0" h="106.0" x="10379.0" y="3103.0"/> <glyph class="macromolecule" id="wnc1_wnc4_s126_wnc1_wnc4_sa97"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="10390.0" y="3115.0"/> <glyph class="state variable" id="_9382653d-0314-44e5-a438-a41a750b9465"> <state value="" variable="S268"/> <bbox w="30.0" h="10.0" x="10375.492" y="3110.0"/> </glyph> <glyph class="state variable" id="_ad0b1f45-5b5d-4046-bd17-d9ff7e8f0e1a"> <state value="" variable="S269"/> <bbox w="30.0" h="10.0" x="10415.032" y="3110.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s125_wnc1_wnc4_sa98"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Gα12*"/> <bbox w="35.0" h="25.0" x="10411.0" y="3157.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc4_s127_wnc1_wnc4_csa12" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:E-Cadherin*:G_alpha__sub_12_endsub_* Identifiers_end References_begin: s_wnc4_re30:(MAP:survival) PMID:11136230 s_wnc4_re31(MAP:survival): binding of G-alpha12 toE-cadherin results of loss of binding of b-catenin from the adherence junction PMID:11136230 References_end</body> </html> </notes> <label text="E-Cadherin*:Gα12*"/> <bbox w="179.0" h="111.0" x="10428.0" y="3289.0"/> <glyph class="macromolecule" id="wnc1_wnc4_s128_wnc1_wnc4_sa99"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Gα12*"/> <bbox w="35.0" h="25.0" x="10500.0" y="3307.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s129_wnc1_wnc4_sa100"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="154.0" h="40.0" x="10443.0" y="3335.0"/> <glyph class="state variable" id="_b3074812-6990-41bb-afd8-ce18cefbe0ee"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10592.0" y="3330.0"/> </glyph> <glyph class="state variable" id="_b11640d9-9bf0-4741-9fdd-a01bd2bca24e"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="10430.454" y="3330.0"/> </glyph> <glyph class="state variable" id="_5f967c86-8f50-4d7b-b9be-cfe802597648"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="10582.0" y="3330.2148"/> </glyph> <glyph class="state variable" id="_28f604db-4fca-43ef-a750-d623e63b8baa"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="10576.39" y="3370.0"/> </glyph> <glyph class="state variable" id="_699555f3-0c22-48c4-abc3-5f1d84d17024"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="10428.462" y="3370.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc4_s131_wnc1_wnc4_csa13" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AXIN*:G_alpha__sub_12_endsub_* Identifiers_end References_begin: s_wnc4_re32:(MAP:survival) PMID:16868183 References_end</body> </html> </notes> <label text="AXIN*:Gα12*"/> <bbox w="100.0" h="120.0" x="10456.0" y="3442.0"/> <glyph class="macromolecule" id="wnc1_wnc4_s133_wnc1_wnc4_sa102"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="10466.0" y="3493.0"/> <glyph class="state variable" id="_0cd13d81-52ab-4a0f-8b36-e6f8f9b80b2e"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="10453.992" y="3488.0"/> </glyph> <glyph class="state variable" id="_47b62059-2e8f-4036-aac7-99e3b8e9ad19"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="10493.532" y="3488.0"/> </glyph> <glyph class="state variable" id="_e470c5b0-273a-41e7-8d31-b3f8ce9bb110"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="10531.0" y="3488.2148"/> </glyph> <glyph class="state variable" id="_4f926ba0-1f0e-4321-96b3-2cba2ad20d7d"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="10530.382" y="3528.0"/> </glyph> <glyph class="state variable" id="_e76622f9-c638-4ff8-beed-ce9c07ca2c14"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="10490.904" y="3528.0"/> </glyph> <glyph class="state variable" id="_86c4e91c-40dd-43de-ae1a-bef14937041a"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="10451.0" y="3527.7224"/> </glyph> <glyph class="state variable" id="_dfba577e-9d5a-4c2d-8824-0374bfba74da"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="10493.404" y="3528.0"/> </glyph> <glyph class="state variable" id="_6d24c3cc-c9fc-45cc-92a7-2efab1383bbc"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="10532.882" y="3528.0"/> </glyph> <glyph class="state variable" id="_0958c742-4511-495b-9b5f-14ec7e064060"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="10538.5" y="3488.2148"/> </glyph> <glyph class="state variable" id="_5677f758-9414-4ca6-b52b-aff70e2dfca0"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="10453.5" y="3527.7224"/> </glyph> <glyph class="state variable" id="_7e1c9087-1e53-49b2-a0b2-814d31ba635e"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="10458.992" y="3488.0"/> </glyph> <glyph class="state variable" id="_34896c0b-4db1-452a-8bbd-b73f0652419f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10461.0" y="3488.0"/> </glyph> <glyph class="state variable" id="_43bfd511-f660-4d7c-b895-a98ef67c099b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10541.0" y="3488.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s132_wnc1_wnc4_sa103"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Gα12*"/> <bbox w="35.0" h="25.0" x="10488.0" y="3465.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc4_s146_wnc1_wnc4_csa14" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER2:PtdIns- Identifiers_end References_begin: PMID:22898821 s_wnc4_re36:(MAP:survival) PMID:22898821, References_end</body> </html> </notes> <label text="AMER2:PtdIns-"/> <bbox w="100.0" h="120.0" x="10653.0" y="2961.0"/> <glyph class="macromolecule" id="wnc1_wnc4_s148_wnc1_wnc4_sa115"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: APC membrane recruitment protein 2 FAM123A, "family with sequence similarity 123A" HUGO:AMER2 HGNC:26360 ENTREZ:219287 UNIPROT:Q8N7J2 GENECARDS:AMER2 KEGG:219287 WIKI:AMER2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="AMER2"/> <bbox w="80.0" h="40.0" x="10666.0" y="3003.0"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc4_s149_wnc1_wnc4_sa116"> <label text="PtdIns-(4,5)-P2"/> <bbox w="70.0" h="25.0" x="10670.0" y="2972.5"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc4_s157_wnc1_wnc4_csa15" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER2:APC:EB1*:PtdIns- Identifiers_end References_begin: PMID:22898821 s_wnc4_re36:(MAP:survival) PMID:22898821, References_end</body> </html> </notes> <label text="AMER2:APC:EB1*:PtdIns-"/> <bbox w="110.0" h="204.0" x="10876.0" y="2959.0"/> <glyph class="macromolecule" id="wnc1_wnc4_s151_wnc1_wnc4_sa117"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: APC membrane recruitment protein 2 FAM123A, "family with sequence similarity 123A" HUGO:AMER2 HGNC:26360 ENTREZ:219287 UNIPROT:Q8N7J2 GENECARDS:AMER2 KEGG:219287 WIKI:AMER2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="AMER2"/> <bbox w="80.0" h="40.0" x="10895.0" y="3002.0"/> </glyph> <glyph class="simple chemical" id="wnc1_wnc4_s152_wnc1_wnc4_sa118"> <label text="PtdIns-(4,5)-P2"/> <bbox w="70.0" h="25.0" x="10893.0" y="2970.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s153_wnc1_wnc4_sa119"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microtubule-associated protein, RP/EB family, member 1 "adenomatous polyposis coli-binding protein EB1", EB1 HUGO:MAPRE1 HGNC:6890 ENTREZ:22919 UNIPROT:Q15691 GENECARDS:MAPRE1 REACTOME:58935 KEGG:22919 ATLASONC:MAPRE1ID455ch20q11 WIKI:MAPRE1 microtubule-associated protein, RP/EB family, member 2 HUGO:MAPRE2 HGNC:6891 ENTREZ:10982 UNIPROT:Q15555 GENECARDS:MAPRE2 KEGG:10982 ATLASONC:GC_MAPRE2 WIKI:MAPRE2 microtubule-associated protein, RP/EB family, member 3 HUGO:MAPRE3 HGNC:6892 ENTREZ:22924 UNIPROT:Q9UPY8 GENECARDS:MAPRE3 KEGG:22924 ATLASONC:GC_MAPRE3 WIKI:MAPRE3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="EB1*"/> <bbox w="80.0" h="40.0" x="10895.0" y="3045.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s156_wnc1_wnc4_sa120"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="10895.0" y="3087.0"/> <glyph class="state variable" id="_cab55d6b-04ee-495c-abed-51f95fde1658"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="10956.882" y="3122.0"/> </glyph> <glyph class="state variable" id="_dd034002-c048-4582-be64-9a272a28ff67"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="10877.992" y="3082.0"/> </glyph> <glyph class="state variable" id="_86a1c2ed-3bb1-4e5b-846b-66befe337fad"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="10957.5" y="3082.2148"/> </glyph> <glyph class="state variable" id="_308449e5-c70b-42a8-979a-c27e0260413f"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="10917.404" y="3122.0"/> </glyph> <glyph class="state variable" id="_c777f9fe-dd00-475e-84c2-8dfed014b873"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="10917.532" y="3082.0"/> </glyph> <glyph class="state variable" id="_5a187a72-2509-486e-b0bd-05277c1bc5fd"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="10877.5" y="3121.7224"/> </glyph> <glyph class="state variable" id="_1fa54323-118a-46f0-8b7f-c0178f9f7d50"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10970.0" y="3082.0"/> </glyph> <glyph class="state variable" id="_47b3c4c1-4500-4d8b-be9d-0a55c09ec7c3"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="10957.5" y="3121.1306"/> </glyph> <glyph class="state variable" id="_537cbb9d-952c-4e3a-9b06-64a0a111f0cd"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="10877.5" y="3121.7224"/> </glyph> <glyph class="state variable" id="_bf0215df-4edd-4f2a-baf8-76c507f4de8d"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="10882.992" y="3082.0"/> </glyph> <glyph class="state variable" id="_b27baa08-9442-448a-b4c1-f502b5391086"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="10877.992" y="3082.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc4_s166_wnc1_wnc4_csa16" compartmentRef="wnc1_wnc4_c4_wnc1_wnc4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC_sub_TRUNC_endsub_*:HTID1_40_kDA_isoform* Identifiers_end References_begin: s_wnc4_re44(MAP:survival): The 40 kDa isoform has high affinity for cleaved APC, this results in decreased apoptsis PMID:19900451 References_end</body> </html> </notes> <label text="APCTRUNC*:HTID1_40_kDA_isoform*"/> <bbox w="100.0" h="120.0" x="10868.0" y="3676.0"/> <glyph class="macromolecule" id="wnc1_wnc4_s168_wnc1_wnc4_sa128"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DnaJ (Hsp40) homolog, subfamily A, member 3 HUGO:DNAJA3 HGNC:11808 ENTREZ:9093 UNIPROT:Q96EY1 GENECARDS:DNAJA3 KEGG:9093 ATLASONC:DNAJA3ID40342ch16p13 WIKI:DNAJA3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Different splice isoforms: Tid50, Tid48 and Tid46 are present in the cytosol and Tid43, Tid40 and Tid38 translocate into the mitochondrium PMID:17588722 References_end</body> </html> </notes> <label text="HTID1_40_kDA_isoform*"/> <bbox w="80.0" h="40.0" x="10876.0" y="3730.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s167_wnc1_wnc4_sa129"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: adenomatous polyposis coli "adenomatosis polyposis coli" HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="APCTRUNC*"/> <bbox w="80.0" h="40.0" x="10875.75" y="3688.0"/> <glyph class="unit of information" id="_7071bc72-a5fc-4fd0-a19c-82f50854765c"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10890.75" y="3683.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc4_s175_wnc1_wnc4_csa17" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC:AXIN*:Actin cytoskeletal*:DVL*:HSC70*:HSP70*:HTID1_50_48_kDa_isoform* Identifiers_end References_begin: s_wnc4_re45:(MAP:survival) PMID:17588722 References_end</body> </html> </notes> <label text="APC:AXIN*:Actin cytoskeletal*:DVL*:HSC70*:HSP70*:HTID1_50_48_kDa_isoform*"/> <bbox w="195.0" h="222.0" x="10437.0" y="3593.0"/> <glyph class="macromolecule" id="wnc1_wnc4_s181_wnc1_wnc4_sa136"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="10453.0" y="3644.5"/> <glyph class="state variable" id="_d87f1746-a57a-4fea-96e3-65befe37d018"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10528.0" y="3639.5"/> </glyph> <glyph class="state variable" id="_c3131cbf-47a4-46b5-8d9d-bf191dc2613d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10448.0" y="3639.5"/> </glyph> <glyph class="state variable" id="_95c03aa5-e9bd-4952-958b-ee769a2c9711"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="10517.382" y="3679.5"/> </glyph> <glyph class="state variable" id="_22eab671-1746-4823-b28a-a36e3ef43990"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10448.0" y="3639.5"/> </glyph> <glyph class="state variable" id="_a1ba7250-ad61-4b09-a3f4-bf64001cc85c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10528.0" y="3639.5"/> </glyph> <glyph class="state variable" id="_21adead2-d829-4d82-8a8e-33a3ea32fd67"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10527.634" y="3639.5"/> </glyph> <glyph class="state variable" id="_d20f8fa3-dd25-4589-91b4-5727c18a7bd4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10528.0" y="3679.5"/> </glyph> <glyph class="state variable" id="_6a10ae2d-50a6-4158-89de-6c372f7ac5f8"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="10438.0" y="3679.2224"/> </glyph> <glyph class="state variable" id="_8b0535bc-5b62-4eb5-b6ae-e0b13f085586"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10448.0" y="3679.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s176_wnc1_wnc4_sa137"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: heat shock 70kDa protein 1A "heat shock 70kD protein 1A", HSPA1 HUGO:HSPA1A HGNC:5232 ENTREZ:3303 UNIPROT:P08107 GENECARDS:HSPA1A REACTOME:56682 KEGG:3303 ATLASONC:GC_HSPA1A WIKI:HSPA1A HUGO:HSPA1B HGNC:5233 ENTREZ:3304 UNIPROT:P08107 GENECARDS:HSPA1B REACTOME:56682 KEGG:3304 ATLASONC:GC_HSPA1B WIKI:HSPA1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HSP70*"/> <bbox w="80.0" h="40.0" x="10453.0" y="3600.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s177_wnc1_wnc4_sa138"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: heat shock 70kDa protein 8 "heat shock 70kD protein 8", HSPA10 HUGO:HSPA8 HGNC:5241 ENTREZ:3312 UNIPROT:P11142 GENECARDS:HSPA8 REACTOME:56692 KEGG:3312 ATLASONC:GC_HSPA8 WIKI:HSPA8 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HSC70*"/> <bbox w="80.0" h="40.0" x="10539.0" y="3689.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s178_wnc1_wnc4_sa139"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: actin, alpha 1, skeletal muscle NEM3, "nemaline myopathy type 3" HUGO:ACTA1 HGNC:129 ENTREZ:58 UNIPROT:P68133 GENECARDS:ACTA1 REACTOME:49626 KEGG:58 ATLASONC:GC_ACTA1 WIKI:ACTA1 actin, beta HUGO:ACTB HGNC:132 ENTREZ:60 UNIPROT:P60709 GENECARDS:ACTB REACTOME:49576 KEGG:60 ATLASONC:ACTBID42959ch7p22 WIKI:ACTB actin, gamma 1 HUGO:ACTG1 HGNC:144 ENTREZ:71 UNIPROT:P63261 GENECARDS:ACTG1 REACTOME:49603 KEGG:71 ATLASONC:GC_ACTG1 WIKI:ACTG1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Actin cytoskeletal*"/> <bbox w="80.0" h="40.0" x="10453.0" y="3689.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s179_wnc1_wnc4_sa140"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="10539.0" y="3644.5"/> <glyph class="state variable" id="_e958afe3-83bc-4495-ade7-2a05b113f883"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="10526.992" y="3639.5"/> </glyph> <glyph class="state variable" id="_6501c484-5fb3-4b54-b99d-747ba3f85692"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="10566.532" y="3639.5"/> </glyph> <glyph class="state variable" id="_d251733b-a55e-493b-83b7-4637df330204"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="10604.0" y="3639.7148"/> </glyph> <glyph class="state variable" id="_1c39c3c0-9672-4d7d-bef3-423093941bc6"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="10603.382" y="3679.5"/> </glyph> <glyph class="state variable" id="_2771e29c-bab7-443a-ae93-0294d9877818"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="10563.904" y="3679.5"/> </glyph> <glyph class="state variable" id="_1874e137-0902-4661-9142-e981ce30a240"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="10524.0" y="3679.2224"/> </glyph> <glyph class="state variable" id="_d7f5dd66-a60a-4231-83b3-69740f19ea6b"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="10566.404" y="3679.5"/> </glyph> <glyph class="state variable" id="_86aa852b-e0b1-4751-9668-d94cfc132fc7"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="10605.882" y="3679.5"/> </glyph> <glyph class="state variable" id="_7acefff1-a04a-4591-a347-3723fc95516f"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="10611.5" y="3639.7148"/> </glyph> <glyph class="state variable" id="_3d996bdb-2503-4598-aacb-f8c0826f260c"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="10526.5" y="3679.2224"/> </glyph> <glyph class="state variable" id="_f3389915-1b56-4c0a-a6e6-c9295d5567bf"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="10531.992" y="3639.5"/> </glyph> <glyph class="state variable" id="_9a59432f-587b-4a95-8447-aac96d5efde0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10534.0" y="3639.5"/> </glyph> <glyph class="state variable" id="_bf4c3f4b-fe40-4b01-a56d-64f483150758"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10614.0" y="3639.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s180_wnc1_wnc4_sa141"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DnaJ (Hsp40) homolog, subfamily A, member 3 HUGO:DNAJA3 HGNC:11808 ENTREZ:9093 UNIPROT:Q96EY1 GENECARDS:DNAJA3 KEGG:9093 ATLASONC:DNAJA3ID40342ch16p13 WIKI:DNAJA3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Different splice isoforms: Tid50, Tid48 and Tid46 are present in the cytosol and Tid43, Tid40 and Tid38 translocate into the mitochondrium PMID:17588722 References_end</body> </html> </notes> <label text="HTID1_50_48_kDa_isoform*"/> <bbox w="80.0" h="40.0" x="10539.0" y="3600.5"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s182_wnc1_wnc4_sa142"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="10494.0" y="3733.0"/> <glyph class="state variable" id="_13e8bc00-479a-4a1c-8f71-0ce0ef0b89e5"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="10555.882" y="3768.0"/> </glyph> <glyph class="state variable" id="_9c7862e5-53a4-4eb3-a892-b97c20180993"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="10476.992" y="3728.0"/> </glyph> <glyph class="state variable" id="_01a56f60-7ba2-44e7-b78a-674d76a40291"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="10556.5" y="3728.2148"/> </glyph> <glyph class="state variable" id="_9dae0169-b4ac-406a-a903-cc2b3648ca1d"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="10516.404" y="3768.0"/> </glyph> <glyph class="state variable" id="_5503b09c-a3f4-458c-87ba-05716951cc82"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="10516.532" y="3728.0"/> </glyph> <glyph class="state variable" id="_29632d9c-fb83-4d1e-af5f-50d46e1636ae"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="10476.5" y="3767.7224"/> </glyph> <glyph class="state variable" id="_a2429255-a075-4ac8-b43a-ccbf49e65749"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10569.0" y="3728.0"/> </glyph> <glyph class="state variable" id="_b173ecb6-32f8-4d33-b19f-4519f1278e3f"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="10556.5" y="3767.1306"/> </glyph> <glyph class="state variable" id="_8c648efb-490a-405d-9290-361816c4bc36"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="10476.5" y="3767.7224"/> </glyph> <glyph class="state variable" id="_edd8ea4c-2f6b-452c-8c8c-3cea9173de40"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="10481.992" y="3728.0"/> </glyph> <glyph class="state variable" id="_e0997b6d-49cc-413f-9d0d-f567cd02bb73"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="10476.992" y="3728.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc4_s183_wnc1_wnc4_csa2" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Cytoskeleton:E-Cadherin*:_alpha_-Catenin*:_beta_-Catenin*:p120* Identifiers_end References_begin: s_wnc4_re24(MAP:survival): Complex of G-alpha12 and p120 stabilises binding of E-cadherin in Adhesion-complex. G-alpha12 is found back in complex with p120 and E-cadherin PMID:15240885 s_wnc4_re4:(MAP:survival) PMID:22558232 s_wnc4_re31(MAP:survival): binding of G-alpha12 toE-cadherin results of loss of binding of b-catenin from the adherence junction PMID:11136230 References_end</body> </html> </notes> <label text="(Adhesion-complex)"/> <bbox w="293.0" h="159.0" x="9774.0" y="3156.0"/> <glyph class="macromolecule" id="wnc1_wnc4_s20_wnc1_wnc4_sa10"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="9884.0" y="3211.0"/> <glyph class="state variable" id="_0776d7a4-eb04-4d6e-824d-ce137b5465f1"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="9911.404" y="3246.0"/> </glyph> <glyph class="state variable" id="_0a8f2522-9ec7-4620-b8aa-27c5e7345d1b"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="9950.882" y="3246.0"/> </glyph> <glyph class="state variable" id="_30b136b1-e139-4048-9225-5beb5f9ce188"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="9951.5" y="3206.2148"/> </glyph> <glyph class="state variable" id="_869ee7aa-ee35-4cda-b24e-7e3fc77d5213"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="9911.532" y="3206.0"/> </glyph> <glyph class="state variable" id="_2c0429ba-64e2-4568-989e-96bff1f9684e"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="9871.992" y="3206.0"/> </glyph> <glyph class="state variable" id="_3f115bf7-48ee-461d-9fba-15771646615e"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="9871.5" y="3245.7224"/> </glyph> <glyph class="state variable" id="_f4ed77a9-a34f-48b3-a9d7-caf70bac368f"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="9949.0" y="3206.2148"/> </glyph> <glyph class="state variable" id="_22c23b95-cf44-4220-9e8e-4ea8632d115b"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="9949.0" y="3206.2148"/> </glyph> <glyph class="state variable" id="_d2f890cb-21f2-48a1-b0a5-c8d4719da24d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9879.0" y="3226.0"/> </glyph> <glyph class="state variable" id="_dcf67ba3-c79a-4a7f-94f3-48039d43fa0b"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="9869.492" y="3206.0"/> </glyph> <glyph class="state variable" id="_78f058d8-8331-4150-8796-acc90e01a0c5"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="9949.0" y="3206.2148"/> </glyph> <glyph class="state variable" id="_03fb4b69-55d1-473b-9fb5-b36cf79df16d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9879.0" y="3217.7158"/> </glyph> <glyph class="state variable" id="_1fadfc8f-5c3b-4a06-ba53-abd9edb2e14b"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="9949.0" y="3206.2148"/> </glyph> <glyph class="state variable" id="_659e8443-43f5-48d7-9741-db4fd0a8c4f7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9879.0" y="3226.0"/> </glyph> <glyph class="state variable" id="_1ebd8556-218b-4a1d-9a17-3cff0461d688"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="9948.382" y="3246.0"/> </glyph> <glyph class="state variable" id="_0086e19b-9498-4643-806a-853fec804364"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="9949.0" y="3206.2148"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s21_wnc1_wnc4_sa11"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="154.0" h="40.0" x="9810.0" y="3168.0"/> <glyph class="state variable" id="_40f13d4f-53e6-4e19-91de-3175d28ee3c4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9959.0" y="3163.0"/> </glyph> <glyph class="state variable" id="_0b1ea337-7010-4dd8-bb94-61d694628d54"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="9797.454" y="3163.0"/> </glyph> <glyph class="state variable" id="_a1a14223-efac-45a0-a9f8-f7e887cf602f"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="9949.0" y="3163.2148"/> </glyph> <glyph class="state variable" id="_4aa7b9b2-7ddd-4e25-b03b-94f41cf19a1a"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="9943.39" y="3203.0"/> </glyph> <glyph class="state variable" id="_bb474ba6-b253-458d-8f35-3ec7873098c2"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="9795.462" y="3203.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s22_wnc1_wnc4_sa12"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="9802.0" y="3212.0"/> <glyph class="state variable" id="_cbd97a78-8d8c-498a-b6da-ddccfde7ac44"> <state value="" variable="S268"/> <bbox w="30.0" h="10.0" x="9787.492" y="3207.0"/> </glyph> <glyph class="state variable" id="_d39b44ca-60aa-4156-8dd3-de0789219e7a"> <state value="" variable="S269"/> <bbox w="30.0" h="10.0" x="9827.032" y="3207.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s23_wnc1_wnc4_sa13"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) alpha 1 102kDa HUGO:CTNNA1 HGNC:2509 ENTREZ:1495 UNIPROT:P35221 GENECARDS:CTNNA1 REACTOME:53044 KEGG:1495 ATLASONC:GC_CTNNA1 WIKI:CTNNA1 catenin (cadherin-associated protein) alpha 2 HUGO:CTNNA2 HGNC:2510 ENTREZ:1496 UNIPROT:P26232 GENECARDS:CTNNA2 REACTOME:53046 KEGG:1496 WIKI:CTNNA2 catenin (cadherin-associated protein) alpha 3 HUGO:CTNNA3 HGNC:2511 ENTREZ:29119 UNIPROT:Q9UI47 GENECARDS:CTNNA3 KEGG:29119 ATLASONC:GC_CTNNA3 WIKI:CTNNA3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: catenin (cadherin-associated protein) alpha 1 102kDa HUGO:CTNNA1 HGNC:2509 ENTREZ:1495 UNIPROT:P35221 GENECARDS:CTNNA1 REACTOME:53044 KEGG:1495 ATLASONC:GC_CTNNA1 WIKI:CTNNA1 catenin (cadherin-associated protein) alpha 2 HUGO:CTNNA2 HGNC:2510 ENTREZ:1496 UNIPROT:P26232 GENECARDS:CTNNA2 REACTOME:53046 KEGG:1496 WIKI:CTNNA2 catenin (cadherin-associated protein) alpha 3 HUGO:CTNNA3 HGNC:2511 ENTREZ:29119 UNIPROT:Q9UI47 GENECARDS:CTNNA3 KEGG:29119 ATLASONC:GC_CTNNA3 WIKI:CTNNA3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="α-Catenin*"/> <bbox w="75.0" h="85.0" x="9967.0" y="3167.0"/> </glyph> <glyph class="phenotype" id="wnc1_wnc4_s24_wnc1_wnc4_sa14"> <label text="Cytoskeleton"/> <bbox w="80.0" h="30.0" x="9963.0" y="3256.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc4_s184_wnc1_wnc4_csa3" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Cytoskeleton:E-Cadherin*:_alpha_-Catenin*:_beta_-Catenin*:p120* Identifiers_end References_begin: s_wnc4_re4:(MAP:survival) PMID:22558232 s_wnc4_re5:(MAP:survival) PMID:16099633 References_end</body> </html> </notes> <label text="(Adhesion-complex)"/> <bbox w="293.0" h="159.0" x="9774.0" y="3381.5"/> <glyph class="macromolecule" id="wnc1_wnc4_s36_wnc1_wnc4_sa15"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="9884.0" y="3436.5"/> <glyph class="state variable" id="_ab76f352-efa8-4eaf-b06b-d1313d3c1231"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="9911.404" y="3471.5"/> </glyph> <glyph class="state variable" id="_882a2311-233f-4e82-a378-1ad71c2567dd"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="9950.882" y="3471.5"/> </glyph> <glyph class="state variable" id="_9e30a0df-1f44-4f65-bb9b-8bfea53fc603"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="9951.5" y="3431.7148"/> </glyph> <glyph class="state variable" id="_dead249e-678f-46b7-b52c-0ca32418e6fa"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="9911.532" y="3431.5"/> </glyph> <glyph class="state variable" id="_01407766-cf42-46d3-833a-42d3da4d0108"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="9871.992" y="3431.5"/> </glyph> <glyph class="state variable" id="_87398416-8e87-4b1b-9d84-1c380b5b5df9"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="9871.5" y="3471.2224"/> </glyph> <glyph class="state variable" id="_2a2e6fb6-6e74-45e7-9a5c-e29f354cbed6"> <state value="P" variable="Y142"/> <bbox w="35.0" h="10.0" x="9946.5" y="3431.7148"/> </glyph> <glyph class="state variable" id="_ce94cfac-8ce3-43a3-9d44-12814ea01c3d"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="9949.0" y="3431.7148"/> </glyph> <glyph class="state variable" id="_8ee94083-3fcd-4060-8b7b-14bdc0658296"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9879.0" y="3451.5"/> </glyph> <glyph class="state variable" id="_7376c9c0-0346-465a-8444-fb6c07bfc775"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="9869.492" y="3431.5"/> </glyph> <glyph class="state variable" id="_4e7b0b75-a94b-4655-b85c-74b9d518aaa2"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="9949.0" y="3431.7148"/> </glyph> <glyph class="state variable" id="_d49af50c-3e16-43ed-aab4-ac0da7aa5711"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9879.0" y="3443.2158"/> </glyph> <glyph class="state variable" id="_52b9c199-38c7-4801-aeba-e65a71e88f62"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="9949.0" y="3431.7148"/> </glyph> <glyph class="state variable" id="_a8958dfe-661c-4910-a8d4-e2400114290b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9879.0" y="3451.5"/> </glyph> <glyph class="state variable" id="_a155ae18-db18-4399-bc37-87f4f85dd8a2"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="9948.382" y="3471.5"/> </glyph> <glyph class="state variable" id="_8fec6627-c614-49cd-a501-97a1adb5f240"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="9949.0" y="3431.7148"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s32_wnc1_wnc4_sa16"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="154.0" h="40.0" x="9810.0" y="3393.5"/> <glyph class="state variable" id="_669fcf27-0859-45a1-b1cd-592ca12d49af"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9959.0" y="3388.5"/> </glyph> <glyph class="state variable" id="_9ed2c8a3-3cbf-4a44-a780-09c56934f06f"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="9797.454" y="3388.5"/> </glyph> <glyph class="state variable" id="_ca1e2902-ad4f-4c96-83ba-b8688f0ccfab"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="9949.0" y="3388.7148"/> </glyph> <glyph class="state variable" id="_a564884f-fcab-44ed-a1c4-1015b605705d"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="9943.39" y="3428.5"/> </glyph> <glyph class="state variable" id="_dd374e26-bdb2-4d88-9c9b-3ab8ddec5cf3"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="9795.462" y="3428.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s33_wnc1_wnc4_sa17"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="9802.0" y="3437.5"/> <glyph class="state variable" id="_f3bd6763-d78c-4eea-95dd-8e1aa7f80e88"> <state value="" variable="S268"/> <bbox w="30.0" h="10.0" x="9787.492" y="3432.5"/> </glyph> <glyph class="state variable" id="_dfab14f9-3e16-4973-8c3e-f7a5b4fdf2c1"> <state value="" variable="S269"/> <bbox w="30.0" h="10.0" x="9827.032" y="3432.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s34_wnc1_wnc4_sa18"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) alpha 1 102kDa HUGO:CTNNA1 HGNC:2509 ENTREZ:1495 UNIPROT:P35221 GENECARDS:CTNNA1 REACTOME:53044 KEGG:1495 ATLASONC:GC_CTNNA1 WIKI:CTNNA1 catenin (cadherin-associated protein) alpha 2 HUGO:CTNNA2 HGNC:2510 ENTREZ:1496 UNIPROT:P26232 GENECARDS:CTNNA2 REACTOME:53046 KEGG:1496 WIKI:CTNNA2 catenin (cadherin-associated protein) alpha 3 HUGO:CTNNA3 HGNC:2511 ENTREZ:29119 UNIPROT:Q9UI47 GENECARDS:CTNNA3 KEGG:29119 ATLASONC:GC_CTNNA3 WIKI:CTNNA3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: catenin (cadherin-associated protein) alpha 1 102kDa HUGO:CTNNA1 HGNC:2509 ENTREZ:1495 UNIPROT:P35221 GENECARDS:CTNNA1 REACTOME:53044 KEGG:1495 ATLASONC:GC_CTNNA1 WIKI:CTNNA1 catenin (cadherin-associated protein) alpha 2 HUGO:CTNNA2 HGNC:2510 ENTREZ:1496 UNIPROT:P26232 GENECARDS:CTNNA2 REACTOME:53046 KEGG:1496 WIKI:CTNNA2 catenin (cadherin-associated protein) alpha 3 HUGO:CTNNA3 HGNC:2511 ENTREZ:29119 UNIPROT:Q9UI47 GENECARDS:CTNNA3 KEGG:29119 ATLASONC:GC_CTNNA3 WIKI:CTNNA3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="α-Catenin*"/> <bbox w="75.0" h="85.0" x="9967.0" y="3392.5"/> </glyph> <glyph class="phenotype" id="wnc1_wnc4_s35_wnc1_wnc4_sa19"> <label text="Cytoskeleton"/> <bbox w="80.0" h="30.0" x="9963.0" y="3481.5"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc4_s185_wnc1_wnc4_csa4" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:E-Cadherin*:_alpha_-Catenin*:cytoskeleton:p120* Identifiers_end References_begin: s_wnc4_re5:(MAP:survival) PMID:16099633 References_end</body> </html> </notes> <label text="(Adhesion-complex)"/> <bbox w="293.0" h="159.0" x="9774.0" y="3629.5"/> <glyph class="macromolecule" id="wnc1_wnc4_s38_wnc1_wnc4_sa20"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="154.0" h="40.0" x="9810.0" y="3641.5"/> <glyph class="state variable" id="_3eed6967-b7dc-4901-bfef-1c533e5d6d2b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9959.0" y="3636.5"/> </glyph> <glyph class="state variable" id="_02d98f77-b951-464e-b4e7-bc63bbaf5357"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="9797.454" y="3636.5"/> </glyph> <glyph class="state variable" id="_372d95d6-3932-48ec-92f2-258c50b1b7bc"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="9949.0" y="3636.7148"/> </glyph> <glyph class="state variable" id="_fd05f702-b591-41ba-baa5-78c17f7eb954"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="9943.39" y="3676.5"/> </glyph> <glyph class="state variable" id="_f6833b81-e53f-4575-a34a-6c20ded5dda2"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="9795.462" y="3676.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s39_wnc1_wnc4_sa21"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="9802.0" y="3685.5"/> <glyph class="state variable" id="_e63ff420-28b8-4f84-8139-be657424afe6"> <state value="" variable="S268"/> <bbox w="30.0" h="10.0" x="9787.492" y="3680.5"/> </glyph> <glyph class="state variable" id="_877863a1-7439-4dba-b7c9-c99d5b169510"> <state value="" variable="S269"/> <bbox w="30.0" h="10.0" x="9827.032" y="3680.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s40_wnc1_wnc4_sa22"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) alpha 1 102kDa HUGO:CTNNA1 HGNC:2509 ENTREZ:1495 UNIPROT:P35221 GENECARDS:CTNNA1 REACTOME:53044 KEGG:1495 ATLASONC:GC_CTNNA1 WIKI:CTNNA1 catenin (cadherin-associated protein) alpha 2 HUGO:CTNNA2 HGNC:2510 ENTREZ:1496 UNIPROT:P26232 GENECARDS:CTNNA2 REACTOME:53046 KEGG:1496 WIKI:CTNNA2 catenin (cadherin-associated protein) alpha 3 HUGO:CTNNA3 HGNC:2511 ENTREZ:29119 UNIPROT:Q9UI47 GENECARDS:CTNNA3 KEGG:29119 ATLASONC:GC_CTNNA3 WIKI:CTNNA3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: catenin (cadherin-associated protein) alpha 1 102kDa HUGO:CTNNA1 HGNC:2509 ENTREZ:1495 UNIPROT:P35221 GENECARDS:CTNNA1 REACTOME:53044 KEGG:1495 ATLASONC:GC_CTNNA1 WIKI:CTNNA1 catenin (cadherin-associated protein) alpha 2 HUGO:CTNNA2 HGNC:2510 ENTREZ:1496 UNIPROT:P26232 GENECARDS:CTNNA2 REACTOME:53046 KEGG:1496 WIKI:CTNNA2 catenin (cadherin-associated protein) alpha 3 HUGO:CTNNA3 HGNC:2511 ENTREZ:29119 UNIPROT:Q9UI47 GENECARDS:CTNNA3 KEGG:29119 ATLASONC:GC_CTNNA3 WIKI:CTNNA3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="α-Catenin*"/> <bbox w="75.0" h="85.0" x="9967.0" y="3640.5"/> </glyph> <glyph class="phenotype" id="wnc1_wnc4_s41_wnc1_wnc4_sa23"> <label text="cytoskeleton"/> <bbox w="80.0" h="30.0" x="9963.0" y="3729.5"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc4_s186_wnc1_wnc4_csa9" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AXIN1:GSK3*:MYC:PIN1 Identifiers_end References_begin: s_wnc4_re14:(MAP:survival) PMID:19131971 References_end</body> </html> </notes> <label text="(c-Myc destruction complex)"/> <bbox w="267.0" h="123.0" x="11042.0" y="4400.5"/> <glyph class="macromolecule" id="wnc1_wnc4_s83_wnc1_wnc4_sa57"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) "v-myc avian myelocytomatosis viral oncogene homolog" HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: C-MYC is a key regulator of cell proliferation differentiaton and apoptosis. The biological functions of C-MYC are thought to depend in part on the polypeptide binding partners with which it interacts. PMID:11274345 References_end Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) "v-myc avian myelocytomatosis viral oncogene homolog" HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 GENECARDS:MYC REACTOME:59773 KEGG:4609 ATLASONC:MYCID27 WIKI:MYC Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: C-MYC is a key regulator of cell proliferation differentiaton and apoptosis. The biological functions of C-MYC are thought to depend in part on the polypeptide binding partners with which it interacts. PMID:11274345 References_end</body> </html> </notes> <label text="MYC"/> <bbox w="80.0" h="40.0" x="11052.25" y="4456.0"/> <glyph class="state variable" id="_15856d9c-db46-4f17-aee5-9f516edb0153"> <state value="P" variable="T58"/> <bbox w="30.0" h="10.0" x="11037.25" y="4490.722"/> </glyph> <glyph class="state variable" id="_d14eb087-776c-44cd-a28c-ed9c89ba7dad"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="11119.75" y="4451.215"/> </glyph> <glyph class="state variable" id="_edb399de-bdf6-4c2d-b3a6-bd9781e2ef67"> <state value="P" variable="S62"/> <bbox w="30.0" h="10.0" x="11037.742" y="4451.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s80_wnc1_wnc4_sa58"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="11137.0" y="4456.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s81_wnc1_wnc4_sa59"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: peptidylprolyl cis/trans isomerase, NIMA-interacting 1 "protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1" HUGO:PIN1 HGNC:8988 ENTREZ:5300 UNIPROT:Q13526 GENECARDS:PIN1 REACTOME:69717 KEGG:5300 ATLASONC:GC_PIN1 WIKI:PIN1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PIN1"/> <bbox w="80.0" h="40.0" x="11215.0" y="4456.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s82_wnc1_wnc4_sa60"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="AXIN1"/> <bbox w="80.0" h="40.0" x="11051.0" y="4412.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc4_s187_wnc1_wnc4_csa10" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AXIN1:GSK3*:MYC:PIN1 Identifiers_end References_begin: s_wnc4_re15:(MAP:survival) PMID:19131971 References_end</body> </html> </notes> <label text="(c-Myc destruction complex)"/> <bbox w="266.0" h="119.0" x="10718.0" y="4402.5"/> <glyph class="macromolecule" id="wnc1_wnc4_s94_wnc1_wnc4_sa64"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) "v-myc avian myelocytomatosis viral oncogene homolog" HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: C-MYC is a key regulator of cell proliferation differentiaton and apoptosis. The biological functions of C-MYC are thought to depend in part on the polypeptide binding partners with which it interacts. PMID:11274345 References_end Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) "v-myc avian myelocytomatosis viral oncogene homolog" HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 GENECARDS:MYC REACTOME:59773 KEGG:4609 ATLASONC:MYCID27 WIKI:MYC Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: C-MYC is a key regulator of cell proliferation differentiaton and apoptosis. The biological functions of C-MYC are thought to depend in part on the polypeptide binding partners with which it interacts. PMID:11274345 References_end</body> </html> </notes> <label text="MYC"/> <bbox w="80.0" h="40.0" x="10728.25" y="4458.0"/> <glyph class="state variable" id="_33e6651f-a235-4a72-99ee-615f4cf53297"> <state value="P" variable="T58"/> <bbox w="30.0" h="10.0" x="10713.25" y="4492.722"/> </glyph> <glyph class="state variable" id="_c35a6f8b-5158-4ae8-8213-80278a857543"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="10795.75" y="4453.215"/> </glyph> <glyph class="state variable" id="_4ccd31a0-2443-4adb-9915-9f39dc6d4cd5"> <state value="" variable="S62"/> <bbox w="25.0" h="10.0" x="10716.242" y="4453.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s88_wnc1_wnc4_sa65"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="10813.0" y="4458.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s89_wnc1_wnc4_sa66"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: peptidylprolyl cis/trans isomerase, NIMA-interacting 1 "protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1" HUGO:PIN1 HGNC:8988 ENTREZ:5300 UNIPROT:Q13526 GENECARDS:PIN1 REACTOME:69717 KEGG:5300 ATLASONC:GC_PIN1 WIKI:PIN1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PIN1"/> <bbox w="80.0" h="40.0" x="10891.0" y="4458.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s90_wnc1_wnc4_sa67"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="AXIN1"/> <bbox w="80.0" h="40.0" x="10727.0" y="4414.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc4_s188_wnc1_wnc4_csa7" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PP2A_A*:PP2A_B*:PP2_C* Identifiers_end References_begin: s_wnc4_re15:(MAP:survival) PMID:19131971 References_end</body> </html> </notes> <label text="(PP2A)"/> <bbox w="269.0" h="69.0" x="10719.0" y="4312.0"/> <glyph class="macromolecule" id="wnc1_wnc4_s63_wnc1_wnc4_sa44"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: protein phosphatase 2 regulatory subunit A alpha HUGO:PPP2R1A HGNC:9302 ENTREZ:5518 UNIPROT:P30153 GENECARDS:PPP2R1A REACTOME:49125 KEGG:5518 ATLASONC:GC_PPP2R1A WIKI:PPP2R1A protein phosphatase 2 regulatory subunit B beta HUGO:PPP2R1B HGNC:9303 ENTREZ:5519 UNIPROT:P30154 GENECARDS:PPP2R1B REACTOME:49127 KEGG:5519 ATLASONC:GC_PPP2R1B WIKI:PPP2R1B PP2A-Aalpha, PR65A, "protein phosphatase 2, 65kDa regulatory subunit A", "protein phosphatase 2A, regulatory subunit A, alpha isoform" protein phosphatase 2, regulatory subunit A, beta Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18559511 PMID:10026142 Structural sub-unit References_end Identifiers_begin: protein phosphatase 2 regulatory subunit A alpha HUGO:PPP2R1A HGNC:9302 ENTREZ:5518 UNIPROT:P30153 GENECARDS:PPP2R1A REACTOME:49125 KEGG:5518 ATLASONC:GC_PPP2R1A WIKI:PPP2R1A protein phosphatase 2 regulatory subunit B beta HUGO:PPP2R1B HGNC:9303 ENTREZ:5519 UNIPROT:P30154 GENECARDS:PPP2R1B REACTOME:49127 KEGG:5519 ATLASONC:GC_PPP2R1B WIKI:PPP2R1B PP2A-Aalpha, PR65A, "protein phosphatase 2, 65kDa regulatory subunit A", "protein phosphatase 2A, regulatory subunit A, alpha isoform" protein phosphatase 2, regulatory subunit A, beta Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18559511 PMID:10026142 Structural sub-unit References_end</body> </html> Identifiers_begin: protein phosphatase 2 regulatory subunit A alpha HUGO:PPP2R1A HGNC:9302 ENTREZ:5518 UNIPROT:P30153 GENECARDS:PPP2R1A REACTOME:49125 KEGG:5518 ATLASONC:GC_PPP2R1A WIKI:PPP2R1A protein phosphatase 2 regulatory subunit B beta HUGO:PPP2R1B HGNC:9303 ENTREZ:5519 UNIPROT:P30154 GENECARDS:PPP2R1B REACTOME:49127 KEGG:5519 ATLASONC:GC_PPP2R1B WIKI:PPP2R1B PP2A-Aalpha, PR65A, "protein phosphatase 2, 65kDa regulatory subunit A", "protein phosphatase 2A, regulatory subunit A, alpha isoform" protein phosphatase 2, regulatory subunit A, beta Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18559511 PMID:10026142 Structural sub-unit References_end</body> </html> </notes> <label text="PP2A_A*"/> <bbox w="80.0" h="40.0" x="10730.0" y="4322.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s64_wnc1_wnc4_sa45"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 2, catalytic subunit, alpha isozyme PP2Calpha, "protein phosphatase 2A catalytic subunit, alpha isoform" HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA protein phosphatase 2, catalytic subunit, beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PP2_C*"/> <bbox w="80.0" h="40.0" x="10811.5" y="4322.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s65_wnc1_wnc4_sa46"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: protein phosphatase 2 regulatory subunit B alpha HUGO:PPP2R2A HGNC:9304 ENTREZ:5520 UNIPROT:P63151 GENECARDS:PPP2R2A REACTOME:49129 KEGG:5520 ATLASONC:GC_PPP2R2A WIKI:PPP2R2A P63151 protein phosphatase 2 regulatory subunit B beta HUGO:PPP2R2B HGNC:9305 ENTREZ:5521 UNIPROT:Q00005 GENECARDS:PPP2R2B KEGG:5521 ATLASONC:GC_PPP2R2B WIKI:PPP2R2B Q00005 protein phosphatase 2 regulatory subunit B gamma HUGO:PPP2R2C HGNC:9306 ENTREZ:5522 UNIPROT:Q9Y2T4 GENECARDS:PPP2R2C KEGG:5522 ATLASONC:GC_PPP2R2C WIKI:PPP2R2C Q9Y2T4 protein phosphatase 2 regulatory subunit B delta HUGO:PPP2R2D HGNC:23732 ENTREZ:55844 UNIPROT:Q66LE6 GENECARDS:PPP2R2D REACTOME:217408 KEGG:55844 ATLASONC:GC_PPP2R2D WIKI:PPP2R2D Q66LE6 PP2A 55 kDa regulatory subunit B beta isoform PP2A 55 kDa regulatory subunit B gamma isoform PP2A 55 kDa regulatory subunit B delta isoform PP2A 72/130 kDa regulatory subunit B HUGO:PPP2R3A HGNC:9307 ENTREZ:5523 UNIPROT:Q06190 GENECARDS:PPP2R3A KEGG:5523 ATLASONC:GC_PPP2R3A WIKI:PPP2R3A PP2A 48 kDa regulatory subunit B HUGO:PPP2R3B HGNC:13417 ENTREZ:28227 UNIPROT:Q9Y5P8 GENECARDS:PPP2R3B REACTOME:49140 KEGG:28227 ATLASONC:GC_PPP2R3B WIKI:PPP2R3B PP2A regulatory subunit B'' subunit gamma HUGO:PPP2R3C HGNC:17485 ENTREZ:55012 UNIPROT:Q969Q6 GENECARDS:PPP2R3C KEGG:55012 WIKI:PPP2R3C PP2A regulatory subunit B' HUGO:PPP2R4 HGNC:9308 ENTREZ:5524 UNIPROT:Q15257 GENECARDS:PPP2R4 KEGG:5524 ATLASONC:PPP2R4ID41817ch9q34 WIKI:PPP2R4 PP2A 56 kDa regulatory subunit alpha isoform HUGO:PPP2R5A HGNC:9309 ENTREZ:5525 UNIPROT:Q15172 GENECARDS:PPP2R5A REACTOME:49115 KEGG:5525 ATLASONC:GC_PPP2R5A WIKI:PPP2R5A PP2A 56 kDa regulatory subunit beta isoform HUGO:PPP2R5B HGNC:9310 ENTREZ:5526 UNIPROT:Q15173 GENECARDS:PPP2R5B REACTOME:405832 KEGG:5526 ATLASONC:GC_PPP2R5B WIKI:PPP2R5B PP2A 56 kDa regulatory subunit gamma isoform HUGO:PPP2R5C HGNC:9311 ENTREZ:5527 UNIPROT:Q13362 GENECARDS:PPP2R5C REACTOME:405599 KEGG:5527 ATLASONC:GC_PPP2R5C WIKI:PPP2R5C PP2A 56 kDa regulatory subunit delta isoform HUGO:PPP2R5D HGNC:9312 ENTREZ:5528 UNIPROT:Q14738 GENECARDS:PPP2R5D REACTOME:405743 KEGG:5528 ATLASONC:GC_PPP2R5D WIKI:PPP2R5D PP2A 56 kDa regulatory subunit epsilon isoform HUGO:PPP2R5E HGNC:9313 ENTREZ:5529 UNIPROT:Q16537 GENECARDS:PPP2R5E REACTOME:49121 ATLASONC:GC_PPP2R5E WIKI:PPP2R5E Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 References_end Identifiers_begin: protein phosphatase 2 regulatory subunit B alpha HUGO:PPP2R2A HGNC:9304 ENTREZ:5520 UNIPROT:P63151 GENECARDS:PPP2R2A REACTOME:49129 KEGG:5520 ATLASONC:GC_PPP2R2A WIKI:PPP2R2A P63151 protein phosphatase 2 regulatory subunit B beta HUGO:PPP2R2B HGNC:9305 ENTREZ:5521 UNIPROT:Q00005 GENECARDS:PPP2R2B KEGG:5521 ATLASONC:GC_PPP2R2B WIKI:PPP2R2B Q00005 protein phosphatase 2 regulatory subunit B gamma HUGO:PPP2R2C HGNC:9306 ENTREZ:5522 UNIPROT:Q9Y2T4 GENECARDS:PPP2R2C KEGG:5522 ATLASONC:GC_PPP2R2C WIKI:PPP2R2C Q9Y2T4 protein phosphatase 2 regulatory subunit B delta HUGO:PPP2R2D HGNC:23732 ENTREZ:55844 UNIPROT:Q66LE6 GENECARDS:PPP2R2D REACTOME:217408 KEGG:55844 ATLASONC:GC_PPP2R2D WIKI:PPP2R2D Q66LE6 PP2A 55 kDa regulatory subunit B beta isoform PP2A 55 kDa regulatory subunit B gamma isoform PP2A 55 kDa regulatory subunit B delta isoform PP2A 72/130 kDa regulatory subunit B HUGO:PPP2R3A HGNC:9307 ENTREZ:5523 UNIPROT:Q06190 GENECARDS:PPP2R3A KEGG:5523 ATLASONC:GC_PPP2R3A WIKI:PPP2R3A PP2A 48 kDa regulatory subunit B HUGO:PPP2R3B HGNC:13417 ENTREZ:28227 UNIPROT:Q9Y5P8 GENECARDS:PPP2R3B REACTOME:49140 KEGG:28227 ATLASONC:GC_PPP2R3B WIKI:PPP2R3B PP2A regulatory subunit B'' subunit gamma HUGO:PPP2R3C HGNC:17485 ENTREZ:55012 UNIPROT:Q969Q6 GENECARDS:PPP2R3C KEGG:55012 WIKI:PPP2R3C PP2A regulatory subunit B' HUGO:PPP2R4 HGNC:9308 ENTREZ:5524 UNIPROT:Q15257 GENECARDS:PPP2R4 KEGG:5524 ATLASONC:PPP2R4ID41817ch9q34 WIKI:PPP2R4 PP2A 56 kDa regulatory subunit alpha isoform HUGO:PPP2R5A HGNC:9309 ENTREZ:5525 UNIPROT:Q15172 GENECARDS:PPP2R5A REACTOME:49115 KEGG:5525 ATLASONC:GC_PPP2R5A WIKI:PPP2R5A PP2A 56 kDa regulatory subunit beta isoform HUGO:PPP2R5B HGNC:9310 ENTREZ:5526 UNIPROT:Q15173 GENECARDS:PPP2R5B REACTOME:405832 KEGG:5526 ATLASONC:GC_PPP2R5B WIKI:PPP2R5B PP2A 56 kDa regulatory subunit gamma isoform HUGO:PPP2R5C HGNC:9311 ENTREZ:5527 UNIPROT:Q13362 GENECARDS:PPP2R5C REACTOME:405599 KEGG:5527 ATLASONC:GC_PPP2R5C WIKI:PPP2R5C PP2A 56 kDa regulatory subunit delta isoform HUGO:PPP2R5D HGNC:9312 ENTREZ:5528 UNIPROT:Q14738 GENECARDS:PPP2R5D REACTOME:405743 KEGG:5528 ATLASONC:GC_PPP2R5D WIKI:PPP2R5D PP2A 56 kDa regulatory subunit epsilon isoform HUGO:PPP2R5E HGNC:9313 ENTREZ:5529 UNIPROT:Q16537 GENECARDS:PPP2R5E REACTOME:49121 ATLASONC:GC_PPP2R5E WIKI:PPP2R5E Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 References_end</body> </html> </notes> <label text="PP2A_B*"/> <bbox w="80.0" h="40.0" x="10893.0" y="4322.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s_wnc4_s189_wnc1_wnc4_csa8" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AXIN1:GSK3*:MYC:PIN1 Identifiers_end References_begin: s_wnc4_re13:(MAP:survival) PMID:19131971 References_end</body> </html> </notes> <label text="(c-Myc destruction complex)"/> <bbox w="261.0" h="127.0" x="11045.0" y="4165.5"/> <glyph class="macromolecule" id="wnc1_wnc4_s71_wnc1_wnc4_sa50"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) "v-myc avian myelocytomatosis viral oncogene homolog" HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: C-MYC is a key regulator of cell proliferation differentiaton and apoptosis. The biological functions of C-MYC are thought to depend in part on the polypeptide binding partners with which it interacts. PMID:11274345 References_end Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) "v-myc avian myelocytomatosis viral oncogene homolog" HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 GENECARDS:MYC REACTOME:59773 KEGG:4609 ATLASONC:MYCID27 WIKI:MYC Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: C-MYC is a key regulator of cell proliferation differentiaton and apoptosis. The biological functions of C-MYC are thought to depend in part on the polypeptide binding partners with which it interacts. PMID:11274345 References_end</body> </html> </notes> <label text="MYC"/> <bbox w="80.0" h="40.0" x="11055.25" y="4221.0"/> <glyph class="state variable" id="_252067fa-98c3-4c00-b889-4e203d3573b5"> <state value="" variable="T58"/> <bbox w="25.0" h="10.0" x="11042.75" y="4255.722"/> </glyph> <glyph class="state variable" id="_1065d52c-b4b0-4fde-9149-4ae310010472"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="11122.75" y="4216.215"/> </glyph> <glyph class="state variable" id="_deede028-d272-4207-bc72-b9050e24af78"> <state value="P" variable="S62"/> <bbox w="30.0" h="10.0" x="11040.742" y="4216.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s72_wnc1_wnc4_sa51"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="11140.0" y="4221.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s73_wnc1_wnc4_sa52"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: peptidylprolyl cis/trans isomerase, NIMA-interacting 1 "protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1" HUGO:PIN1 HGNC:8988 ENTREZ:5300 UNIPROT:Q13526 GENECARDS:PIN1 REACTOME:69717 KEGG:5300 ATLASONC:GC_PIN1 WIKI:PIN1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PIN1"/> <bbox w="80.0" h="40.0" x="11218.0" y="4221.0"/> </glyph> <glyph class="macromolecule" id="wnc1_wnc4_s74_wnc1_wnc4_sa53"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="AXIN1"/> <bbox w="80.0" h="40.0" x="11054.0" y="4177.0"/> </glyph> </glyph> <glyph class="source and sink" id="wnc1_s_wnc4_s97_wnc1_wnc4_sa70" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <label text="26S proteosome"/> <bbox w="30.0" h="30.0" x="11041.0" y="4573.0"/> </glyph> <glyph class="nucleic acid feature" id="wnc1_s_wnc4_s105_wnc1_wnc4_sa78" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: catenin (cadherin-associated protein) beta 1 HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="70.0" h="25.0" x="11478.0" y="4001.5"/> </glyph> <glyph class="nucleic acid feature" id="wnc1_s_wnc4_s119_wnc1_wnc4_sa92" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re26(MAP:survival): In airway smooth muscle cells PMID:21908588 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: It's not a gene but it depicts here all genes coding for all proteins that make up the extracellular matrix References_end</body> </html> </notes> <label text="ECM genes"/> <bbox w="70.0" h="25.0" x="11478.0" y="4050.5"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc4_s56_wnc1_wnc4_sa36" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <label text="Apoptosis"/> <bbox w="80.0" h="30.0" x="11266.0" y="4010.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc4_s57_wnc1_wnc4_sa37" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re11(MAP:survival): Increased transcription of p53-target genes PMID:15526030 References_end</body> </html> </notes> <label text="p53-target genes"/> <bbox w="80.0" h="30.0" x="11268.0" y="4081.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc4_s104_wnc1_wnc4_sa77" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <label text="EMT"/> <bbox w="80.0" h="30.0" x="11062.0" y="4798.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc4_s122_wnc1_wnc4_sa95" compartmentRef="wnc1_wnc4_c5_wnc1_wnc4_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re28:(MAP:survival) PMID:21908588 References_end</body> </html> </notes> <label text="ECM"/> <bbox w="80.0" h="30.0" x="12058.0" y="4047.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc4_s139_wnc1_wnc4_sa109" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <label text="Actin fibers"/> <bbox w="80.0" h="30.0" x="11090.0" y="3356.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc4_s158_wnc1_wnc4_sa121" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <label text="Apoptosis"/> <bbox w="80.0" h="30.0" x="10635.0" y="3434.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc4_s43_wnc1_wnc4_sa25" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <label text="WNT canonical pathway"/> <bbox w="80.0" h="30.0" x="10509.0" y="2989.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc4_s12_wnc1_wnc4_sa9" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <label text="MAPK pathway"/> <bbox w="80.0" h="30.0" x="10135.0" y="3054.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc4_s117_wnc1_wnc4_sa90" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <label text="Cytoskeleton"/> <bbox w="80.0" h="30.0" x="10009.5" y="3101.5"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc4_s111_wnc1_wnc4_sa84" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <label text="TGF-β pathway"/> <bbox w="80.0" h="30.0" x="11543.0" y="3811.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s1_wnc1_wnc4_sa5" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 References_end Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> Identifiers_begin: epidermal growth factor receptor "epidermal growth factor receptor (avian erythroblastic leukemia viral (v-erb-b) oncogene homolog)" ERBB HUGO:EGFR HGNC:3236 ENTREZ:1956 UNIPROT:P00533 GENECARDS:EGFR REACTOME:54208 KEGG:1956 ATLASONC:GC_EGFR WIKI:EGFR v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog (avian) NGL "v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro/glioblastoma derived oncogene homolog)" HUGO:ERBB2 HGNC:3430 ENTREZ:2064 UNIPROT:P04626 GENECARDS:ERBB2 REACTOME:54422 KEGG:2064 ATLASONC:ERBB2ID162ch17q11 WIKI:ERBB2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) LCCS2 "lethal congenital contracture syndrome 2" HUGO:ERBB3 HGNC:3431 ENTREZ:2065 UNIPROT:P21860 GENECARDS:ERBB3 REACTOME:403310 KEGG:2065 ATLASONC:ERBB3ID40479ch12q13 WIKI:ERBB3 v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) "v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 4" HUGO:ERBB4 HGNC:3432 ENTREZ:2066 UNIPROT:Q15303 GENECARDS:ERBB4 REACTOME:54426 KEGG:2066 ATLASONC:GC_ERBB4 WIKI:ERBB4 fibroblast growth factor receptor 1 FLT2 "fms-related tyrosine kinase 2" KAL2 HUGO:FGFR1 HGNC:3688 ENTREZ:2260 UNIPROT:P11362 GENECARDS:FGFR1 REACTOME:402793 KEGG:2260 ATLASONC:FGFR1113 WIKI:FGFR1 fibroblast growth factor receptor 2 "bacteria-expressed kinase" BEK CFD1 "craniofacial dysostosis 1" "Jackson-Weiss syndrome" JWS "keratinocyte growth factor receptor" KGFR HUGO:FGFR2 HGNC:3689 ENTREZ:2263 UNIPROT:P21802 GENECARDS:FGFR2 REACTOME:403305 KEGG:2263 ATLASONC:FGFR2ID40570ch10q26 WIKI:FGFR2 fibroblast growth factor receptor 3 ACH "achondroplasia thanatophoric dwarfism" HUGO:FGFR3 HGNC:3690 ENTREZ:2261 UNIPROT:P22607 GENECARDS:FGFR3 REACTOME:403340 KEGG:2261 ATLASONC:FGFR99 WIKI:FGFR3 fibroblast growth factor receptor 4 HUGO:FGFR4 HGNC:3691 ENTREZ:2264 UNIPROT:P22455 GENECARDS:FGFR4 REACTOME:54820 KEGG:2264 ATLASONC:FGFR4ID512ch5q35 WIKI:FGFR4 fms-related tyrosine kinase 1 FLT "fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)" HUGO:FLT1 HGNC:3763 ENTREZ:2321 UNIPROT:P17948 GENECARDS:FLT1 REACTOME:403120 KEGG:2321 ATLASONC:GC_FLT1 WIKI:FLT1 fms-related tyrosine kinase 3 HUGO:FLT3 HGNC:3765 ENTREZ:2322 UNIPROT:P36888 GENECARDS:FLT3 KEGG:2322 ATLASONC:FLT3ID144 WIKI:FLT3 fms-related tyrosine kinase 4 HUGO:FLT4 HGNC:3767 ENTREZ:2324 UNIPROT:P35916 GENECARDS:FLT4 REACTOME:67176 KEGG:2324 ATLASONC:GC_FLT4 WIKI:FLT4 platelet-derived growth factor receptor alpha polypeptide HUGO:PDGFRA HGNC:8803 ENTREZ:5156 UNIPROT:P16234 GENECARDS:PDGFRA REACTOME:61602 KEGG:5156 ATLASONC:GC_PDGFRA WIKI:PDGFRA platelet-derived growth factor receptor beta polypeptide PDGFR HUGO:PDGFRB HGNC:8804 ENTREZ:5159 UNIPROT:P09619 GENECARDS:PDGFRB REACTOME:61600 KEGG:5159 ATLASONC:PDGFRBID21ch5q32 WIKI:PDGFRB A generic name for this family of receptors that contain a tyrosine kinase activity. rhotekin HUGO:RTKN HGNC:10466 ENTREZ:6242 UNIPROT:Q9BST9 GENECARDS:RTKN ATLASONC:GC_RTKN WIKI:RTKN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: RTKs exist as inactive monomers; after binding to their ligands they form dimers and their intracellular domains are activated. PMID:17496910 PMID:12040186 PMID:19568798 PMID:14585353 RTK stands for receptor tyrosine kinase and consists of approx. 20 different classes (http://en.wikipedia.org/wiki/Receptor_tyrosine_kinase) References_end</body> </html> </notes> <label text="RTK*"/> <bbox w="80.0" h="50.0" x="9893.0" y="3076.0"/> <glyph class="state variable" id="_219f1265-bde4-4661-b150-5e22f897c4c4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9968.0" y="3106.3552"/> </glyph> <glyph class="state variable" id="_983e9b77-dd70-4e28-a03f-9bfbe7375a50"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9968.0" y="3106.3552"/> </glyph> <glyph class="state variable" id="_12fcbd6a-1a42-4985-ae02-f176a3fd2cf6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="9968.0" y="3096.0"/> </glyph> <glyph class="unit of information" id="_9312b939-5c5c-4f3c-99c2-f04dd6ee311f"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="9910.5" y="3071.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s2_wnc1_wnc4_sa2" compartmentRef="wnc1_wnc4_c5_wnc1_wnc4_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: fibroblast growth factor 2 (basic) FGFB HUGO:FGF2 HGNC:3676 ENTREZ:2247 UNIPROT:P09038 GENECARDS:FGF2 REACTOME:54764 KEGG:2247 ATLASONC:FGF2ID511ch4q27 WIKI:FGF2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:ECM MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="FGF2"/> <bbox w="80.0" h="40.0" x="9840.0" y="2923.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s3_wnc1_wnc4_sa3" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LRP6"/> <bbox w="80.0" h="50.0" x="10216.0" y="2985.0"/> <glyph class="state variable" id="_75380b51-292d-41ac-bd8b-3d5d174ea8b5"> <state value="" variable="T1572"/> <bbox w="35.0" h="10.0" x="10198.5" y="3004.9602"/> </glyph> <glyph class="state variable" id="_32355009-7598-4ffa-9b7e-84c35dc09b3b"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="10238.532" y="2980.0"/> </glyph> <glyph class="state variable" id="_eaf1aa64-3e67-47c6-a5ad-658dc10c1934"> <state value="" variable="S1544"/> <bbox w="35.0" h="10.0" x="10278.5" y="2980.2686"/> </glyph> <glyph class="state variable" id="_44c71a42-6c3a-499f-9077-0a9d242da238"> <state value="" variable="T1548"/> <bbox w="35.0" h="10.0" x="10278.5" y="3018.4373"/> </glyph> <glyph class="state variable" id="_6cd97681-1011-4d3e-81f4-4846eee072b2"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="10278.5" y="2980.2686"/> </glyph> <glyph class="state variable" id="_8c6bb685-8d5c-4333-a80b-8b9f7826da26"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="10198.992" y="2980.0"/> </glyph> <glyph class="unit of information" id="_a132a772-163e-4027-98d4-6c23b1d7e87c"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="10233.5" y="2980.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s5_wnc1_wnc4_sa4" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re6(MAP:survival): Phosphorylation of LRP6 by ERKk and simultanious activation by Wnt3 gives a higher activation rate of the canoncical wnt pathway (synergetic effect) PMID:22558232 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LRP6"/> <bbox w="80.0" h="50.0" x="10348.0" y="2985.0"/> <glyph class="state variable" id="_07a418e6-5fff-4bf5-aa2c-4f4aed614f52"> <state value="P" variable="T1572"/> <bbox w="40.0" h="10.0" x="10328.0" y="3004.9602"/> </glyph> <glyph class="state variable" id="_9e28e274-2993-45d6-b9d3-216c08b72eef"> <state value="P" variable="S1490"/> <bbox w="40.0" h="10.0" x="10368.032" y="2980.0"/> </glyph> <glyph class="state variable" id="_02257ca1-19fb-4c47-9313-6a236a8c76a7"> <state value="" variable="S1544"/> <bbox w="35.0" h="10.0" x="10410.5" y="2980.2686"/> </glyph> <glyph class="state variable" id="_7cbc1102-93e3-4f75-96da-8a1c84879edb"> <state value="" variable="T1548"/> <bbox w="35.0" h="10.0" x="10410.5" y="3018.4373"/> </glyph> <glyph class="state variable" id="_23eac77b-fa1f-478b-9637-1fb22b580f99"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="10410.5" y="2980.2686"/> </glyph> <glyph class="state variable" id="_6159d7ce-bb36-4c0a-b3ab-b8d200a43f7e"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="10330.992" y="2980.0"/> </glyph> <glyph class="unit of information" id="_655b65ec-e800-458a-8d5f-cbc3dabbb1b1"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="10365.5" y="2980.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s11_wnc1_wnc4_sa8" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end Identifiers_begin: mitogen-activated protein kinase 1 PRKM1 PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1 REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1 mitogen-activated protein kinase 3 PRKM3 HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 GENECARDS:MAPK3 KEGG:5595 ATLASONC:MAPK3ID425ch16p11 WIKI:MAPK3 mitogen-activated protein kinase 4 HUGO:MAPK4 HGNC:6878 ENTREZ:5596 UNIPROT:P31152 GENECARDS:MAPK4 KEGG:5596 ATLASONC:MAPK4ID41293ch18q21 WIKI:MAPK4 mitogen-activated protein kinase 6 HUGO:MAPK6 HGNC:6879 ENTREZ:5597 UNIPROT:Q16659 GENECARDS:MAPK6 KEGG:5597 ATLASONC:MAPK6ID43349ch15q21 WIKI:MAPK6 ERK, ERK2, MAPK2, p41mapk Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Phosphorylated ERK negatively regulates KSR1/B-Raf interaction downregulating signal transmission. In restig cells ERK1/2 are localised in the cytoplasm due to binding to many cytoplasmic anchors or scaffold proteins. MP1 specifically binds MEK1 and ERK1 but not MEK2 or ERK2. (Activation on late endosomes) PMID:19541618 PMID:19565474 PMID:15547943 References_end</body> </html> </notes> <label text="ERK*"/> <bbox w="80.0" h="40.0" x="10132.0" y="3147.0"/> <glyph class="state variable" id="_2ace4906-35f9-41f6-a222-fa75772e710b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10127.0" y="3168.9707"/> </glyph> <glyph class="state variable" id="_8cc9f373-7af5-40bf-a649-aef0365e9288"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10127.0" y="3154.0803"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s42_wnc1_wnc4_sa24" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re5:(MAP:survival) PMID:16099633 s_wnc4_re7(MAP:survival): B-catenin phosphorylated at this residues shows increased binding with Bcl9 (mouse homologue Bcl9-2) PMID:15371335 Apperently Bcl9 binds b-catenin independently of Y142 PMID:17113272 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="10124.0" y="3562.5"/> <glyph class="state variable" id="_71019ca3-949f-4e85-b8a8-a74c92d6e2dd"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="10151.404" y="3597.5"/> </glyph> <glyph class="state variable" id="_9bceb6f3-aee7-4372-881c-19a671a4e491"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="10190.882" y="3597.5"/> </glyph> <glyph class="state variable" id="_70f6456a-d38b-4bb5-b833-06c838d64656"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="10191.5" y="3557.7148"/> </glyph> <glyph class="state variable" id="_e4ee6706-b541-4220-8f9d-3b3663eaf98a"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="10151.532" y="3557.5"/> </glyph> <glyph class="state variable" id="_2a07be11-ab93-4658-8568-ad0f6d885d50"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="10111.992" y="3557.5"/> </glyph> <glyph class="state variable" id="_33640a11-551b-477b-a8c9-610c7b49e50c"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="10111.5" y="3597.2224"/> </glyph> <glyph class="state variable" id="_61aeaf9c-cb2c-4a96-80f4-0a9703893197"> <state value="P" variable="Y142"/> <bbox w="35.0" h="10.0" x="10186.5" y="3557.7148"/> </glyph> <glyph class="state variable" id="_6eb58618-9a1e-43cd-b54d-68bea12efe98"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="10189.0" y="3557.7148"/> </glyph> <glyph class="state variable" id="_c29d87f2-0c2a-451a-a7a0-68127c01cb7c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10119.0" y="3577.5"/> </glyph> <glyph class="state variable" id="_64ccbfae-0e48-49fd-aa2e-b4ab73f3a81e"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="10109.492" y="3557.5"/> </glyph> <glyph class="state variable" id="_cccd1a5b-48d6-4697-af7f-39d163ce6854"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="10189.0" y="3557.7148"/> </glyph> <glyph class="state variable" id="_d9d01c74-5ed8-4a35-93f4-b1d3fa6caf20"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10119.0" y="3569.2158"/> </glyph> <glyph class="state variable" id="_27fc24c0-f74f-48ab-a898-d32f162b9d78"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="10189.0" y="3557.7148"/> </glyph> <glyph class="state variable" id="_520cedda-ee02-4a01-992e-4ab211ffd8d5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10119.0" y="3577.5"/> </glyph> <glyph class="state variable" id="_2f7a1733-0a21-4ffa-9e47-e2aa419be672"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="10188.382" y="3597.5"/> </glyph> <glyph class="state variable" id="_9eaa434c-579d-435b-b464-e531b095f003"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="10189.0" y="3557.7148"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s45_wnc1_wnc4_sa27" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="10739.0" y="3987.0"/> <glyph class="state variable" id="_773c7069-e9ad-49cc-bc23-cffc5e09f640"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="10726.992" y="3982.0"/> </glyph> <glyph class="state variable" id="_f61cb128-3f6a-4801-bfa1-c9083dcbdff0"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="10766.532" y="3982.0"/> </glyph> <glyph class="state variable" id="_ef5db97f-fe8f-4882-8ea3-70e2cbb26718"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="10804.0" y="3982.2148"/> </glyph> <glyph class="state variable" id="_fab730e4-852c-461e-98e9-63d809252978"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="10803.382" y="4022.0"/> </glyph> <glyph class="state variable" id="_ed35b4fc-9553-4c51-9ba7-5cd2f2023dc2"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="10763.904" y="4022.0"/> </glyph> <glyph class="state variable" id="_69562455-4477-41eb-8b86-0a34e5c06f60"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="10724.0" y="4021.7224"/> </glyph> <glyph class="state variable" id="_93fb4337-83da-466f-aef2-d60c4dc438cb"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="10766.404" y="4022.0"/> </glyph> <glyph class="state variable" id="_2fd56096-3d21-45ba-8012-ce832dac102a"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="10805.882" y="4022.0"/> </glyph> <glyph class="state variable" id="_4e153b00-b39f-4975-ac74-bf0308139c0c"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="10811.5" y="3982.2148"/> </glyph> <glyph class="state variable" id="_f2adb960-f835-44bf-89a0-142ef7e50397"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="10726.5" y="4021.7224"/> </glyph> <glyph class="state variable" id="_10809ba3-7653-43c6-97e9-ab490413b66f"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="10731.992" y="3982.0"/> </glyph> <glyph class="state variable" id="_7ff10736-4dd8-468f-9b52-29a31b72e074"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10734.0" y="3982.0"/> </glyph> <glyph class="state variable" id="_d04f8fd8-e023-4d5d-97d2-f05675a5848a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10814.0" y="3982.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s46_wnc1_wnc4_sa28" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 References_end Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end</body> </html> Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end</body> </html> Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end</body> </html> </notes> <label text="p53*"/> <bbox w="80.0" h="40.0" x="10739.0" y="4045.0"/> <glyph class="state variable" id="_dbe03672-d567-4492-8ff6-abbd52438da4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10814.0" y="4080.0"/> </glyph> <glyph class="state variable" id="_42a85546-b1a0-4ccc-946d-64f1902eb4fe"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10734.0" y="4040.0"/> </glyph> <glyph class="state variable" id="_4a85b126-263a-4c86-a522-434fe34a8793"> <state value="" variable="S46"/> <bbox w="25.0" h="10.0" x="10806.5" y="4040.2148"/> </glyph> <glyph class="state variable" id="_dd71f931-0a4e-4956-895f-5d0d58a2270f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10734.0" y="4060.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s47_wnc1_wnc4_sa29" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: homeodomain interacting protein kinase 2 "homeodomain-interacting protein kinase 2" HUGO:HIPK2 HGNC:14402 ENTREZ:28996 UNIPROT:Q9H2X6 GENECARDS:HIPK2 KEGG:28996 ATLASONC:HIPK2ID40824ch7q34 WIKI:HIPK2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: HIPK2 is pre-dominantly present in the nucleus PMID:18974774 References_end Identifiers_begin: homeodomain interacting protein kinase 2 "homeodomain-interacting protein kinase 2" HUGO:HIPK2 HGNC:14402 ENTREZ:28996 UNIPROT:Q9H2X6 GENECARDS:HIPK2 KEGG:28996 ATLASONC:HIPK2ID40824ch7q34 WIKI:HIPK2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: HIPK2 is pre-dominantly present in the nucleus PMID:18974774 References_end</body> </html> </notes> <label text="HIPK2"/> <bbox w="80.0" h="40.0" x="10739.0" y="4109.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s58_wnc1_wnc4_sa38" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re13:(MAP:survival) PMID:19131971 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) "v-myc avian myelocytomatosis viral oncogene homolog" HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: C-MYC is a key regulator of cell proliferation differentiaton and apoptosis. The biological functions of C-MYC are thought to depend in part on the polypeptide binding partners with which it interacts. PMID:11274345 References_end Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) "v-myc avian myelocytomatosis viral oncogene homolog" HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 GENECARDS:MYC REACTOME:59773 KEGG:4609 ATLASONC:MYCID27 WIKI:MYC Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: C-MYC is a key regulator of cell proliferation differentiaton and apoptosis. The biological functions of C-MYC are thought to depend in part on the polypeptide binding partners with which it interacts. PMID:11274345 References_end</body> </html> </notes> <label text="MYC"/> <bbox w="80.0" h="40.0" x="10739.0" y="4187.0"/> <glyph class="state variable" id="_32f4f5c2-d02c-446d-ab23-6da5f1057a3c"> <state value="" variable="T58"/> <bbox w="25.0" h="10.0" x="10726.5" y="4221.722"/> </glyph> <glyph class="state variable" id="_15380a39-219f-4bae-b83b-4ef4fa9ebf6d"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="10806.5" y="4182.215"/> </glyph> <glyph class="state variable" id="_6d4eeed4-d4fa-450c-b405-b1d9ce7a641b"> <state value="P" variable="S62"/> <bbox w="30.0" h="10.0" x="10724.492" y="4182.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s60_wnc1_wnc4_sa41" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re13:(MAP:survival) PMID:19131971 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="AXIN1"/> <bbox w="80.0" h="40.0" x="10841.0" y="4212.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s61_wnc1_wnc4_sa73" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re20:(MAP:survival) PMID:22745173 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <clone/> <bbox w="80.0" h="40.0" x="10938.0" y="4667.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s61_wnc1_wnc4_sa76" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re20:(MAP:survival) PMID:22745173 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <clone/> <bbox w="80.0" h="40.0" x="10938.0" y="4772.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s62_wnc1_wnc4_sa43" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re13:(MAP:survival) PMID:19131971 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: peptidylprolyl cis/trans isomerase, NIMA-interacting 1 "protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1" HUGO:PIN1 HGNC:8988 ENTREZ:5300 UNIPROT:Q13526 GENECARDS:PIN1 REACTOME:69717 KEGG:5300 ATLASONC:GC_PIN1 WIKI:PIN1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PIN1"/> <bbox w="80.0" h="40.0" x="10840.0" y="4263.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s95_wnc1_wnc4_sa68" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re17:(MAP:survival) PMID:16969074 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) "v-myc avian myelocytomatosis viral oncogene homolog" HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: C-MYC is a key regulator of cell proliferation differentiaton and apoptosis. The biological functions of C-MYC are thought to depend in part on the polypeptide binding partners with which it interacts. PMID:11274345 References_end Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) "v-myc avian myelocytomatosis viral oncogene homolog" HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 GENECARDS:MYC REACTOME:59773 KEGG:4609 ATLASONC:MYCID27 WIKI:MYC Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: C-MYC is a key regulator of cell proliferation differentiaton and apoptosis. The biological functions of C-MYC are thought to depend in part on the polypeptide binding partners with which it interacts. PMID:11274345 References_end</body> </html> </notes> <label text="MYC"/> <bbox w="80.0" h="40.0" x="10722.25" y="4569.0"/> <glyph class="state variable" id="_ee287e2c-e3db-494c-aa4c-dafbd276fe2c"> <state value="P" variable="T58"/> <bbox w="30.0" h="10.0" x="10707.25" y="4603.722"/> </glyph> <glyph class="state variable" id="_7476e176-a877-4e0f-aac3-198c597679be"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="10789.75" y="4564.215"/> </glyph> <glyph class="state variable" id="_9250d90c-bf99-4658-9cce-519ad6fb1540"> <state value="" variable="S62"/> <bbox w="25.0" h="10.0" x="10710.242" y="4564.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s96_wnc1_wnc4_sa69" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re17:(MAP:survival) PMID:16969074 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) "v-myc avian myelocytomatosis viral oncogene homolog" HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: C-MYC is a key regulator of cell proliferation differentiaton and apoptosis. The biological functions of C-MYC are thought to depend in part on the polypeptide binding partners with which it interacts. PMID:11274345 References_end Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) "v-myc avian myelocytomatosis viral oncogene homolog" HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 GENECARDS:MYC REACTOME:59773 KEGG:4609 ATLASONC:MYCID27 WIKI:MYC Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: C-MYC is a key regulator of cell proliferation differentiaton and apoptosis. The biological functions of C-MYC are thought to depend in part on the polypeptide binding partners with which it interacts. PMID:11274345 References_end</body> </html> </notes> <label text="MYC"/> <bbox w="80.0" h="40.0" x="10890.25" y="4569.0"/> <glyph class="state variable" id="_8a3f3da5-5a6b-497b-86f2-3a6a9bcdcac0"> <state value="P" variable="T58"/> <bbox w="30.0" h="10.0" x="10875.25" y="4603.722"/> </glyph> <glyph class="state variable" id="_9bd476b4-bf30-42ad-aeca-c94ebc6f1221"> <state value="Ub" variable="K63"/> <bbox w="35.0" h="10.0" x="10952.75" y="4564.215"/> </glyph> <glyph class="state variable" id="_7e2d4654-df6a-47bd-a54a-27434e0bd66f"> <state value="" variable="S62"/> <bbox w="25.0" h="10.0" x="10878.242" y="4564.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s98_wnc1_wnc4_sa71" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re17:(MAP:survival) PMID:16969074 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase HUGO:HUWE1 HGNC:30892 ENTREZ:10075 UNIPROT:Q7Z6Z7 GENECARDS:HUWE1 REACTOME:155590 KEGG:10075 ATLASONC:GC_HUWE1 WIKI:HUWE1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HECTH9*"/> <bbox w="80.0" h="40.0" x="10807.0" y="4641.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s99_wnc1_wnc4_sa72" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="AXIN2"/> <bbox w="80.0" h="40.0" x="10816.0" y="4720.0"/> <glyph class="state variable" id="_e02b2cfd-592e-488c-8a24-52490ee376ba"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10891.0" y="4715.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s100_wnc1_wnc4_sa74" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re19:(MAP:survival) PMID:22745173 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: snail homolog 1 (Drosophila) "snail 1 (drosophila homolog), zinc finger protein" HUGO:SNAI1 HGNC:11128 ENTREZ:6615 UNIPROT:O95863 GENECARDS:SNAI1 KEGG:6615 ATLASONC:SNAI1ID452ch20q13 WIKI:SNAI1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="SNAI1"/> <bbox w="80.0" h="40.0" x="11064.0" y="4617.0"/> <glyph class="state variable" id="_6af5091b-acf0-411a-aaea-24af43ace105"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11139.0" y="4612.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s102_wnc1_wnc4_sa75" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re19:(MAP:survival) PMID:22745173 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: snail homolog 1 (Drosophila) "snail 1 (drosophila homolog), zinc finger protein" HUGO:SNAI1 HGNC:11128 ENTREZ:6615 UNIPROT:O95863 GENECARDS:SNAI1 KEGG:6615 ATLASONC:SNAI1ID452ch20q13 WIKI:SNAI1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="SNAI1"/> <bbox w="80.0" h="40.0" x="11064.0" y="4715.0"/> <glyph class="state variable" id="_142d6cb9-2e63-4159-9dff-df8cb8fc6ef7"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="11136.5" y="4710.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s107_wnc1_wnc4_sa80" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re22(MAP:survival): c-Raf; MEK1/2; ERK1/2;HRAS PMID:19906679 TGF-b1 in airway smooth muscle cells PMID:21908588 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase kinase 1 MAPKK1, MEK1 HUGO:MAP2K1 HGNC:6840 ENTREZ:5604 UNIPROT:Q02750 GENECARDS:MAP2K1 REACTOME:59503 KEGG:5604 ATLASONC:GC_MAP2K1 WIKI:MAP2K1 mitogen-activated protein kinase kinase 2 HUGO:MAP2K2 HGNC:6842 ENTREZ:5605 UNIPROT:P36507 GENECARDS:MAP2K2 REACTOME:59505 KEGG:5605 ATLASONC:GC_MAP2K2 WIKI:MAP2K2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MEK1_2*"/> <bbox w="80.0" h="40.0" x="11493.334" y="3867.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s108_wnc1_wnc4_sa81" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re22(MAP:survival): c-Raf; MEK1/2; ERK1/2;HRAS PMID:19906679 TGF-b1 in airway smooth muscle cells PMID:21908588 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 3 ERK1, p44erk1, p44mapk HUGO:MAPK3 HGNC:6877 ENTREZ:5595 UNIPROT:P27361 GENECARDS:MAPK3 KEGG:5595 ATLASONC:MAPK3ID425ch16p11 WIKI:MAPK3 mitogen-activated protein kinase 1 ERK, ERK2, MAPK2, p41mapk HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1 REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ERK1_2*"/> <bbox w="80.0" h="40.0" x="11596.666" y="3867.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s109_wnc1_wnc4_sa82" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re22(MAP:survival): c-Raf; MEK1/2; ERK1/2;HRAS PMID:19906679 TGF-b1 in airway smooth muscle cells PMID:21908588 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HRAS"/> <bbox w="80.0" h="40.0" x="11700.0" y="3867.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s110_wnc1_wnc4_sa83" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: v-raf-1 murine leukemia viral oncogene homolog 1 HUGO:RAF1 HGNC:9829 ENTREZ:5894 UNIPROT:P04049 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Active KRas (on late endosomes) recruits Raf1 (C-Raf) to elicit a MODULE:MAPK signalling pathway. Raf1 MEK1/2 and ERK1/2 may act in the outer side of the Golgi apparatus and attenuate proliferation. PMID:19289794 PMID:19565474 References_end Identifiers_begin: v-raf-1 murine leukemia viral oncogene homolog 1 HUGO:RAF1 HGNC:9829 ENTREZ:5894 UNIPROT:P04049 GENECARDS:RAF1 REACTOME:58255 KEGG:5894 ATLASONC:RAF1ID42032ch3p25 WIKI:RAF1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Active KRas (on late endosomes) recruits Raf1 (C-Raf) to elicit a MODULE:MAPK signalling pathway. Raf1 MEK1/2 and ERK1/2 may act in the outer side of the Golgi apparatus and attenuate proliferation. PMID:19289794 PMID:19565474 References_end</body> </html> </notes> <label text="RAF1"/> <bbox w="80.0" h="40.0" x="11390.0" y="3867.0"/> <glyph class="state variable" id="_354a3a5d-984b-4f79-970a-d3643825f45e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11385.0" y="3882.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s113_wnc1_wnc4_sa86" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) alpha 1 102kDa HUGO:CTNNA1 HGNC:2509 ENTREZ:1495 UNIPROT:P35221 GENECARDS:CTNNA1 REACTOME:53044 KEGG:1495 ATLASONC:GC_CTNNA1 WIKI:CTNNA1 catenin (cadherin-associated protein) alpha 2 HUGO:CTNNA2 HGNC:2510 ENTREZ:1496 UNIPROT:P26232 GENECARDS:CTNNA2 REACTOME:53046 KEGG:1496 WIKI:CTNNA2 catenin (cadherin-associated protein) alpha 3 HUGO:CTNNA3 HGNC:2511 ENTREZ:29119 UNIPROT:Q9UI47 GENECARDS:CTNNA3 KEGG:29119 ATLASONC:GC_CTNNA3 WIKI:CTNNA3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: catenin (cadherin-associated protein) alpha 1 102kDa HUGO:CTNNA1 HGNC:2509 ENTREZ:1495 UNIPROT:P35221 GENECARDS:CTNNA1 REACTOME:53044 KEGG:1495 ATLASONC:GC_CTNNA1 WIKI:CTNNA1 catenin (cadherin-associated protein) alpha 2 HUGO:CTNNA2 HGNC:2510 ENTREZ:1496 UNIPROT:P26232 GENECARDS:CTNNA2 REACTOME:53046 KEGG:1496 WIKI:CTNNA2 catenin (cadherin-associated protein) alpha 3 HUGO:CTNNA3 HGNC:2511 ENTREZ:29119 UNIPROT:Q9UI47 GENECARDS:CTNNA3 KEGG:29119 ATLASONC:GC_CTNNA3 WIKI:CTNNA3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="α-Catenin*"/> <bbox w="75.0" h="85.0" x="10242.5" y="3252.5"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s114_wnc1_wnc4_sa87" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="154.0" h="40.0" x="10141.5" y="3201.5"/> <glyph class="state variable" id="_7f7c778d-adb5-4a72-8084-a6f3a93b10f2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10290.5" y="3196.5"/> </glyph> <glyph class="state variable" id="_47c2e628-b5ec-4284-9f95-5dc634006461"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="10128.954" y="3196.5"/> </glyph> <glyph class="state variable" id="_fe332035-359d-46e3-9cc4-8f73515fcae4"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="10280.5" y="3196.7148"/> </glyph> <glyph class="state variable" id="_225c4882-ef10-418f-896a-d216f2d8e54d"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="10274.89" y="3236.5"/> </glyph> <glyph class="state variable" id="_13b21891-1854-4953-8c3c-49ceade09633"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="10126.962" y="3236.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s115_wnc1_wnc4_sa88" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="10139.5" y="3310.5"/> <glyph class="state variable" id="_00452d74-5784-412d-826f-8bb8485387f8"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="10166.904" y="3345.5"/> </glyph> <glyph class="state variable" id="_2d34307e-3ec6-4ed2-aee9-faf0a4891bb5"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="10206.382" y="3345.5"/> </glyph> <glyph class="state variable" id="_84f34132-ee22-499f-8722-872c2e0031f4"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="10207.0" y="3305.7148"/> </glyph> <glyph class="state variable" id="_8d890b16-2657-4f40-8cff-8e4652746f57"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="10167.032" y="3305.5"/> </glyph> <glyph class="state variable" id="_60f3cce4-3c89-4592-b877-b1a20df16f5f"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="10127.492" y="3305.5"/> </glyph> <glyph class="state variable" id="_2d27fa71-6456-4d7d-ab71-8872541470df"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="10127.0" y="3345.2224"/> </glyph> <glyph class="state variable" id="_83009e9e-29c6-4d00-8d6f-9365f6880b50"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="10204.5" y="3305.7148"/> </glyph> <glyph class="state variable" id="_3c3eed00-5cf1-47b8-baf5-7f9452806f32"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="10204.5" y="3305.7148"/> </glyph> <glyph class="state variable" id="_d0d59109-a06a-4813-9a37-1216e155bce5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10134.5" y="3325.5"/> </glyph> <glyph class="state variable" id="_6a2342a4-1209-44ce-9002-433809f6ae57"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="10124.992" y="3305.5"/> </glyph> <glyph class="state variable" id="_9be8e048-30f6-40b3-9d45-e49a54014551"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="10204.5" y="3305.7148"/> </glyph> <glyph class="state variable" id="_7c7f953f-34a2-4585-ae78-ac940decb597"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10134.5" y="3317.2158"/> </glyph> <glyph class="state variable" id="_167238bd-949f-4700-8d94-893c84b4a9eb"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="10204.5" y="3305.7148"/> </glyph> <glyph class="state variable" id="_f5b98c24-9e8c-4a16-aa23-366c12e6df47"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10134.5" y="3325.5"/> </glyph> <glyph class="state variable" id="_c21291b8-d1c9-4109-9ba6-dd4b9559556a"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="10203.882" y="3345.5"/> </glyph> <glyph class="state variable" id="_702e521d-a625-4b90-9e54-957e1ab88913"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="10204.5" y="3305.7148"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s116_wnc1_wnc4_sa89" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="10141.5" y="3251.5"/> <glyph class="state variable" id="_2b4143ec-5b42-464f-865c-ead8289dea45"> <state value="" variable="S268"/> <bbox w="30.0" h="10.0" x="10126.992" y="3246.5"/> </glyph> <glyph class="state variable" id="_eb657c00-ee8d-456c-a8d9-e4a268f2c3ba"> <state value="" variable="S269"/> <bbox w="30.0" h="10.0" x="10166.532" y="3246.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s121_wnc1_wnc4_sa94" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re28:(MAP:survival) PMID:21908588 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: It is not a real protein but a collection of proteins that make up the extracellular matrix References_end</body> </html> </notes> <label text="ECM proteins*"/> <bbox w="80.0" h="40.0" x="11733.0" y="4043.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s123_wnc1_wnc4_sa96" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re29:(MAP:survival) PMID:15240885 s_wnc4_re30:(MAP:survival) PMID:11136230 s_wnc4_re32:(MAP:survival) PMID:16868183 s_wnc4_re33:(MAP:survival) PMID:18285450 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Gα12*"/> <bbox w="35.0" h="25.0" x="10314.0" y="3413.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s130_wnc1_wnc4_sa101" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re45:(MAP:survival) PMID:17588722 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <clone/> <bbox w="80.0" h="40.0" x="10226.0" y="3477.0"/> <glyph class="state variable" id="_878f985f-0224-4399-a798-3acfabd78da6"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="10213.992" y="3472.0"/> </glyph> <glyph class="state variable" id="_b11c9be2-88d4-4df2-95ac-3e82fa4da4fe"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="10253.532" y="3472.0"/> </glyph> <glyph class="state variable" id="_16edf32b-779f-42d3-af48-5321cc410d5f"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="10291.0" y="3472.2148"/> </glyph> <glyph class="state variable" id="_71244dbb-849c-431d-ac01-7604987ff4a6"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="10290.382" y="3512.0"/> </glyph> <glyph class="state variable" id="_f0bdd507-bafc-4b6c-93f7-3130b4a6fa5d"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="10250.904" y="3512.0"/> </glyph> <glyph class="state variable" id="_12dd97e3-e328-4475-9252-50e19a91d594"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="10211.0" y="3511.7224"/> </glyph> <glyph class="state variable" id="_920d27dc-5e47-4762-ac63-374eba845ea3"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="10253.404" y="3512.0"/> </glyph> <glyph class="state variable" id="_ba8f1488-5e5a-4cb9-a8d2-e6c86e44067b"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="10292.882" y="3512.0"/> </glyph> <glyph class="state variable" id="_bf68043b-3115-43c5-b12b-2144743b2d1e"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="10298.5" y="3472.2148"/> </glyph> <glyph class="state variable" id="_dcbe59f1-f15b-4c55-8f59-b5646f1fc981"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="10213.5" y="3511.7224"/> </glyph> <glyph class="state variable" id="_1978c2f5-6779-49aa-89c2-5d3e2dcdc428"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="10218.992" y="3472.0"/> </glyph> <glyph class="state variable" id="_35e89ddf-c545-47f8-869f-cea892438387"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10221.0" y="3472.0"/> </glyph> <glyph class="state variable" id="_24caea71-d506-4a8e-8c28-e17e9a8421bb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10301.0" y="3472.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s130_wnc1_wnc4_sa133" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re45:(MAP:survival) PMID:17588722 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <clone/> <bbox w="80.0" h="40.0" x="10256.0" y="3678.0"/> <glyph class="state variable" id="_f455c013-b929-4bb3-b665-745790aa120f"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="10243.992" y="3673.0"/> </glyph> <glyph class="state variable" id="_5035d0b0-ca40-4ac5-8606-90f64fa7f240"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="10283.532" y="3673.0"/> </glyph> <glyph class="state variable" id="_789761e1-e90f-4e56-8f39-b2dd8472adcf"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="10321.0" y="3673.2148"/> </glyph> <glyph class="state variable" id="_32ba2024-815f-48aa-bbda-a93b19f4e2df"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="10320.382" y="3713.0"/> </glyph> <glyph class="state variable" id="_4becb42e-8148-4985-b321-bb3416a05388"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="10280.904" y="3713.0"/> </glyph> <glyph class="state variable" id="_6272b1fb-ebb8-44f9-91a1-263c09612220"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="10241.0" y="3712.7224"/> </glyph> <glyph class="state variable" id="_03766989-fc39-4749-ad17-52cc485a81a8"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="10283.404" y="3713.0"/> </glyph> <glyph class="state variable" id="_77b2dbae-4684-45f2-8183-e16e90eb6b44"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="10322.882" y="3713.0"/> </glyph> <glyph class="state variable" id="_d2d49da6-1b5f-4155-a5a3-759cdc2399c1"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="10328.5" y="3673.2148"/> </glyph> <glyph class="state variable" id="_9b0d6873-ba58-4546-aa23-eab85e138929"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="10243.5" y="3712.7224"/> </glyph> <glyph class="state variable" id="_f4ededb9-1b7e-45c2-8be7-e64c9c0f5359"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="10248.992" y="3673.0"/> </glyph> <glyph class="state variable" id="_7bfe4a7e-5a02-4abd-9335-1a68cdba377f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10251.0" y="3673.0"/> </glyph> <glyph class="state variable" id="_e7d0411b-5661-444e-9106-c127c2944319"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10331.0" y="3673.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s136_wnc1_wnc4_sa106" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: IQ motif containing GTPase activating protein 1 HUGO:IQGAP1 HGNC:6110 ENTREZ:8826 UNIPROT:P46940 GENECARDS:IQGAP1 REACTOME:381664 KEGG:8826 ATLASONC:GC_IQGAP1 WIKI:IQGAP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="IQGAP1"/> <bbox w="80.0" h="40.0" x="11018.0" y="3305.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s137_wnc1_wnc4_sa107" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: discs, large homolog 1 (Drosophila) "discs, large (Drosophila) homolog 1" HUGO:DLG1 HGNC:2900 ENTREZ:1739 UNIPROT:Q12959 GENECARDS:DLG1 REACTOME:53722 KEGG:1739 ATLASONC:DLG1ID40333ch3q29 WIKI:DLG1 discs, large homolog 2 (Drosophila) HUGO:DLG2 HGNC:2901 ENTREZ:1740 UNIPROT:Q15700 GENECARDS:DLG2 KEGG:1740 WIKI:DLG2 discs, large homolog 3 (Drosophila) HUGO:DLG3 HGNC:2902 ENTREZ:1741 UNIPROT:Q92796 GENECARDS:DLG3 REACTOME:53726 KEGG:1741 ATLASONC:GC_DLG3 WIKI:DLG3 discs, large homolog 4 (Drosophila) HUGO:DLG4 HGNC:2903 ENTREZ:1742 UNIPROT:P78352 GENECARDS:DLG4 REACTOME:53728 KEGG:1742 WIKI:DLG4 discs, large homolog 5 (Drosophila) HUGO:DLG5 HGNC:2904 ENTREZ:9231 UNIPROT:Q8TDM6 GENECARDS:DLG5 KEGG:9231 ATLASONC:GC_DLG5 WIKI:DLG5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="DLG*"/> <bbox w="80.0" h="40.0" x="10914.0" y="3305.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s138_wnc1_wnc4_sa108" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re36:(MAP:survival) PMID:22898821, References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microtubule-associated protein, RP/EB family, member 1 "adenomatous polyposis coli-binding protein EB1", EB1 HUGO:MAPRE1 HGNC:6890 ENTREZ:22919 UNIPROT:Q15691 GENECARDS:MAPRE1 REACTOME:58935 KEGG:22919 ATLASONC:MAPRE1ID455ch20q11 WIKI:MAPRE1 microtubule-associated protein, RP/EB family, member 2 HUGO:MAPRE2 HGNC:6891 ENTREZ:10982 UNIPROT:Q15555 GENECARDS:MAPRE2 KEGG:10982 ATLASONC:GC_MAPRE2 WIKI:MAPRE2 microtubule-associated protein, RP/EB family, member 3 HUGO:MAPRE3 HGNC:6892 ENTREZ:22924 UNIPROT:Q9UPY8 GENECARDS:MAPRE3 KEGG:22924 ATLASONC:GC_MAPRE3 WIKI:MAPRE3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="EB1*"/> <bbox w="80.0" h="40.0" x="10773.0" y="3090.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s141_wnc1_wnc4_sa111" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="10533.0" y="3170.0"/> <glyph class="state variable" id="_7c3f3859-8cd5-454a-b71f-050bec45c010"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="10594.882" y="3205.0"/> </glyph> <glyph class="state variable" id="_381d8668-43be-4f04-b1b4-097edd739fa9"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="10515.992" y="3165.0"/> </glyph> <glyph class="state variable" id="_42d9fb6b-a5bf-456d-bbb7-d371eaa17689"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="10595.5" y="3165.2148"/> </glyph> <glyph class="state variable" id="_a9293794-f675-471f-970a-882b18e9884c"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="10555.404" y="3205.0"/> </glyph> <glyph class="state variable" id="_6329eecc-398a-465c-ba22-1bc7f21ae5c6"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="10555.532" y="3165.0"/> </glyph> <glyph class="state variable" id="_9eeb58b1-f8af-40a0-be0a-a34f5c6ee837"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="10515.5" y="3204.7224"/> </glyph> <glyph class="state variable" id="_8cfc1356-5558-4352-bea4-d23b0278f162"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10608.0" y="3165.0"/> </glyph> <glyph class="state variable" id="_3b70a31c-c63b-4f3e-a81a-602a294f7804"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="10595.5" y="3204.1306"/> </glyph> <glyph class="state variable" id="_45df6a03-f8bb-447e-9d1b-5cb223347ff0"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="10515.5" y="3204.7224"/> </glyph> <glyph class="state variable" id="_5da2a520-50c7-4165-909b-f2d2e847b4c5"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="10520.992" y="3165.0"/> </glyph> <glyph class="state variable" id="_c4969145-1fd6-4316-a721-cfafc804651e"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="10515.992" y="3165.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s142_wnc1_wnc4_sa113" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re34(MAP:survival): Unknown which amino acid residue PMID:22399895 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="10533.0" y="3061.0"/> <glyph class="state variable" id="_df87c5aa-a5e2-4ea5-8244-cd39c1f4b676"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="10594.882" y="3096.0"/> </glyph> <glyph class="state variable" id="_2f9fdd9e-3df5-4752-bdb0-c5cfbafe73c2"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="10515.992" y="3056.0"/> </glyph> <glyph class="state variable" id="_b701d347-b3f5-4a82-bcda-d5d38559981b"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="10595.5" y="3056.2148"/> </glyph> <glyph class="state variable" id="_13b40001-733f-48ef-8f5b-e9e14c9ad73d"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="10555.404" y="3096.0"/> </glyph> <glyph class="state variable" id="_8375fd30-9f89-47db-8cbc-77e6b121b1a3"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="10555.532" y="3056.0"/> </glyph> <glyph class="state variable" id="_0a027368-35ed-4ede-998b-3e8aaa789503"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="10515.5" y="3095.7224"/> </glyph> <glyph class="state variable" id="_7c4ad081-0c71-46bb-8b9b-1dab01ba16b6"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="10605.5" y="3056.0"/> </glyph> <glyph class="state variable" id="_b8fe05f0-015e-4a76-895f-8887e1cb0f74"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="10595.5" y="3095.1306"/> </glyph> <glyph class="state variable" id="_803d35ab-18e2-4f4d-ba4c-76b1282c9539"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="10515.5" y="3095.7224"/> </glyph> <glyph class="state variable" id="_d5a81eb1-bc8b-4475-bda1-8b952f869269"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="10520.992" y="3056.0"/> </glyph> <glyph class="state variable" id="_92bea382-eb4d-4aca-a19d-ebc5220acccb"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="10515.992" y="3056.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s143_wnc1_wnc4_sa114" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re34(MAP:survival): Unknown which amino acid residue PMID:22399895 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: mitogen-activated protein kinase 1 PRKM1, PRKM2 HUGO:MAPK1 HGNC:6871 ENTREZ:5594 UNIPROT:P28482 GENECARDS:MAPK1 REACTOME:59283 KEGG:5594 ATLASONC:MAPK1ID41288ch22q11 WIKI:MAPK1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ERK2*"/> <bbox w="80.0" h="40.0" x="10336.0" y="3049.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s155_wnc1_wnc4_sa105" compartmentRef="wnc1_wnc4_c3_wnc1_wnc4_ca3"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="11121.0" y="3099.0"/> <glyph class="state variable" id="_2a5f024e-aba9-4535-8a4f-8cae225c4bf8"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="11148.404" y="3134.0"/> </glyph> <glyph class="state variable" id="_3f018330-f680-46f6-bfba-5770296631e8"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="11187.882" y="3134.0"/> </glyph> <glyph class="state variable" id="_46c48dde-5e00-4531-9a6f-ea74c3c45c0b"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="11188.5" y="3094.2148"/> </glyph> <glyph class="state variable" id="_32b1dc80-9367-499e-8ae7-ad1684229dc4"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="11148.532" y="3094.0"/> </glyph> <glyph class="state variable" id="_ef644938-f65f-4d71-8ba6-3452126f51ae"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="11108.992" y="3094.0"/> </glyph> <glyph class="state variable" id="_6015030e-588f-490f-a9a0-8f811873238a"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="11108.5" y="3133.7224"/> </glyph> <glyph class="state variable" id="_52ccb32b-48f4-4f27-8390-1e90473f4d28"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="11186.0" y="3094.2148"/> </glyph> <glyph class="state variable" id="_c46a7e2a-1c65-4f67-8fc4-ce9d3fade6a4"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="11186.0" y="3094.2148"/> </glyph> <glyph class="state variable" id="_cbec5f87-9e60-41ed-bac2-440fdab5f568"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11116.0" y="3114.0"/> </glyph> <glyph class="state variable" id="_9c3f4896-68e7-4b62-80ef-0ab552233e02"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="11106.492" y="3094.0"/> </glyph> <glyph class="state variable" id="_cc665c2b-4541-4eef-a70b-217c1d8e4877"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="11186.0" y="3094.2148"/> </glyph> <glyph class="state variable" id="_8b84bbbf-1a44-4c45-afca-6a48cab60731"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11116.0" y="3105.7158"/> </glyph> <glyph class="state variable" id="_16531417-cdc8-437e-805e-6749ed0ea00d"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="11186.0" y="3094.2148"/> </glyph> <glyph class="state variable" id="_17189acb-fa54-4d48-9cfc-c95d0e20a0ae"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="11116.0" y="3114.0"/> </glyph> <glyph class="state variable" id="_7b2fb5fa-0e5c-4c5a-89f4-669cd77f9369"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="11185.382" y="3134.0"/> </glyph> <glyph class="state variable" id="_47348748-71c3-47fd-86b4-37259ddff78d"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="11186.0" y="3094.2148"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s159_wnc1_wnc4_sa122" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: caspase 8 apoptosis-related cysteine peptidase HUGO:CASP8 HGNC:1509 ENTREZ:841 UNIPROT:Q14790 GENECARDS:CASP8 REACTOME:57032 KEGG:841 ATLASONC:GC_CASP8 WIKI:CASP8 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:9765224 References_end Identifiers_begin: caspase 8 apoptosis-related cysteine peptidase HUGO:CASP8 HGNC:1509 ENTREZ:841 UNIPROT:Q14790 GENECARDS:CASP8 REACTOME:57032 KEGG:841 ATLASONC:GC_CASP8 WIKI:CASP8 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:9765224 References_end</body> </html> </notes> <label text="Caspase8*"/> <bbox w="80.0" h="40.0" x="10632.0" y="3241.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s160_wnc1_wnc4_sa123" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re39(MAP:survival): Positive modulaion PMID:15755874, PMID:23308069 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 8, apoptosis-related cysteine peptidase HUGO:CASP8 HGNC:1509 ENTREZ:841 UNIPROT:Q14790 GENECARDS:CASP8 REACTOME:57032 KEGG:841 ATLASONC:GC_CASP8 WIKI:CASP8 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Caspase8TRUNC*"/> <bbox w="80.0" h="40.0" x="10632.0" y="3335.0"/> <glyph class="unit of information" id="_27ec2991-f963-47fd-aada-31960047b22e"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10647.0" y="3330.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s161_wnc1_wnc4_sa124" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re40:(MAP:survival) PMID:19900451 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: adenomatous polyposis coli "adenomatosis polyposis coli" HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="APCTRUNC*"/> <bbox w="80.0" h="40.0" x="10746.0" y="3169.0"/> <glyph class="unit of information" id="_32b82cc2-846c-4a90-b2e6-522affbe08ea"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10761.0" y="3164.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s162_wnc1_wnc4_sa125" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: caspase 3 apoptosis-related cysteine peptidase "caspase 3 apoptosis-related cysteine protease" HUGO:CASPASE3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: CASPASE3 cleaves KSR1 in apoptotic cells. Thus MEK is sequestered in the cytosol and its interaction with Raf and ERK is prevented. PMID:17613518 References_end Identifiers_begin: caspase 3 apoptosis-related cysteine peptidase "caspase 3 apoptosis-related cysteine protease" HUGO:CASPASE3 GENECARDS:CASPASE3 WIKI:CASPASE3 HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 GENECARDS:CASP3 REACTOME:57022 KEGG:836 ATLASONC:GC_CASP3 WIKI:CASP3 HUGO:CASP3 HGNC:1504 ENTREZ:836 UNIPROT:P42574 GENECARDS:CASP3 REACTOME:57022 KEGG:836 ATLASONC:GC_CASP3 WIKI:CASP3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: CASPASE3 cleaves KSR1 in apoptotic cells. Thus MEK is sequestered in the cytosol and its interaction with Raf and ERK is prevented. PMID:17613518 References_end</body> </html> </notes> <label text="Caspase3TRUNC*"/> <bbox w="80.0" h="40.0" x="10755.0" y="3429.0"/> <glyph class="unit of information" id="_825a894b-2233-4d4a-b685-7f97b21d317e"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10770.0" y="3424.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s163_wnc1_wnc4_sa126" compartmentRef="wnc1_wnc4_c4_wnc1_wnc4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re43(MAP:survival): transcription-independent apc-mediated apoptosis PMID:19900451, PMID:17297457 s_wnc4_re44(MAP:survival): The 40 kDa isoform has high affinity for cleaved APC, this results in decreased apoptsis PMID:19900451 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: adenomatous polyposis coli "adenomatosis polyposis coli" HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="APCTRUNC*"/> <bbox w="80.0" h="40.0" x="10962.0" y="3588.0"/> <glyph class="unit of information" id="_2dfd0187-91b1-40e1-86d9-5ff9c5890df7"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="10977.0" y="3583.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s164_wnc1_wnc4_sa127" compartmentRef="wnc1_wnc4_c4_wnc1_wnc4_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re44(MAP:survival): The 40 kDa isoform has high affinity for cleaved APC, this results in decreased apoptsis PMID:19900451 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: DnaJ (Hsp40) homolog, subfamily A, member 3 HUGO:DNAJA3 HGNC:11808 ENTREZ:9093 UNIPROT:Q96EY1 GENECARDS:DNAJA3 KEGG:9093 ATLASONC:DNAJA3ID40342ch16p13 WIKI:DNAJA3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Different splice isoforms: Tid50, Tid48 and Tid46 are present in the cytosol and Tid43, Tid40 and Tid38 translocate into the mitochondrium PMID:17588722 References_end</body> </html> </notes> <label text="HTID1_40_kDA_isoform*"/> <bbox w="80.0" h="40.0" x="10792.0" y="3588.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s169_wnc1_wnc4_sa130" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re45:(MAP:survival) PMID:17588722 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: DnaJ (Hsp40) homolog, subfamily A, member 3 HUGO:DNAJA3 HGNC:11808 ENTREZ:9093 UNIPROT:Q96EY1 GENECARDS:DNAJA3 KEGG:9093 ATLASONC:DNAJA3ID40342ch16p13 WIKI:DNAJA3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Different splice isoforms: Tid50, Tid48 and Tid46 are present in the cytosol and Tid43, Tid40 and Tid38 translocate into the mitochondrium PMID:17588722 References_end</body> </html> </notes> <label text="HTID1_50_48_kDa_isoform*"/> <bbox w="80.0" h="40.0" x="10256.0" y="3621.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s170_wnc1_wnc4_sa131" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re45:(MAP:survival) PMID:17588722 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heat shock 70kDa protein 1A "heat shock 70kD protein 1A", HSPA1 HUGO:HSPA1A HGNC:5232 ENTREZ:3303 UNIPROT:P08107 GENECARDS:HSPA1A REACTOME:56682 KEGG:3303 ATLASONC:GC_HSPA1A WIKI:HSPA1A HUGO:HSPA1B HGNC:5233 ENTREZ:3304 UNIPROT:P08107 GENECARDS:HSPA1B REACTOME:56682 KEGG:3304 ATLASONC:GC_HSPA1B WIKI:HSPA1B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HSP70*"/> <bbox w="80.0" h="40.0" x="10121.0" y="3621.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s171_wnc1_wnc4_sa132" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="10121.0" y="3678.0"/> <glyph class="state variable" id="_1f5ec3f7-c323-4ccf-9292-7011c215c8a8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10196.0" y="3673.0"/> </glyph> <glyph class="state variable" id="_1438c387-2cd9-443a-80a9-7d0941e6e348"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10116.0" y="3673.0"/> </glyph> <glyph class="state variable" id="_0e6a1aac-0254-4513-aa51-581d4912c8b2"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="10185.382" y="3713.0"/> </glyph> <glyph class="state variable" id="_078eba10-591d-4c44-ba2c-9f6e38548a4a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10116.0" y="3673.0"/> </glyph> <glyph class="state variable" id="_252fd22d-0d68-4c7d-b348-f3a4d6a289a7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10196.0" y="3673.0"/> </glyph> <glyph class="state variable" id="_a71eb92a-3954-4981-8577-a55d7206ff0f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10195.634" y="3673.0"/> </glyph> <glyph class="state variable" id="_48fdc815-809d-45db-bd67-b54bfd338c41"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10196.0" y="3713.0"/> </glyph> <glyph class="state variable" id="_c577d5e3-d818-4aa7-9c6c-9e99e1aa7368"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="10106.0" y="3712.7224"/> </glyph> <glyph class="state variable" id="_226cc858-c895-4104-a6a7-ab5cd8cc9c49"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="10116.0" y="3713.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s172_wnc1_wnc4_sa134" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re45:(MAP:survival) PMID:17588722 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: actin, alpha 1, skeletal muscle NEM3, "nemaline myopathy type 3" HUGO:ACTA1 HGNC:129 ENTREZ:58 UNIPROT:P68133 GENECARDS:ACTA1 REACTOME:49626 KEGG:58 ATLASONC:GC_ACTA1 WIKI:ACTA1 actin, beta HUGO:ACTB HGNC:132 ENTREZ:60 UNIPROT:P60709 GENECARDS:ACTB REACTOME:49576 KEGG:60 ATLASONC:ACTBID42959ch7p22 WIKI:ACTB actin, gamma 1 HUGO:ACTG1 HGNC:144 ENTREZ:71 UNIPROT:P63261 GENECARDS:ACTG1 REACTOME:49603 KEGG:71 ATLASONC:GC_ACTG1 WIKI:ACTG1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Actin cytoskeletal*"/> <bbox w="80.0" h="40.0" x="10121.0" y="3742.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s_wnc4_s173_wnc1_wnc4_sa135" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re45:(MAP:survival) PMID:17588722 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: heat shock 70kDa protein 8 "heat shock 70kD protein 8", HSPA10 HUGO:HSPA8 HGNC:5241 ENTREZ:3312 UNIPROT:P11142 GENECARDS:HSPA8 REACTOME:56692 KEGG:3312 ATLASONC:GC_HSPA8 WIKI:HSPA8 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HSC70*"/> <bbox w="80.0" h="40.0" x="10256.0" y="3742.0"/> </glyph> <glyph class="nucleic acid feature" id="wnc1_s_wnc4_s106_wnc1_wnc4_sa79" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 ; ; ; Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 ; ; ; Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="90.0" h="25.0" x="11606.0" y="4001.5"/> <glyph class="unit of information" id="_6a1c3558-3dcb-4c46-951d-5ccd806ace18"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="11641.0" y="3996.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wnc1_s_wnc4_s120_wnc1_wnc4_sa93" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re26(MAP:survival): In airway smooth muscle cells PMID:21908588 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: It's not a gene but it depicts here all genes coding for all proteins that make up the extracellular matrix References_end</body> </html> </notes> <label text="ECM genes"/> <bbox w="90.0" h="25.0" x="11606.0" y="4050.5"/> <glyph class="unit of information" id="_519537bd-ef36-42fa-bb0c-9e8909695841"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="11641.0" y="4045.5"/> </glyph> </glyph> <glyph class="phenotype" id="wnc1_s_wnc4_s44_wnc1_wnc4_sa26" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re7(MAP:survival): B-catenin phosphorylated at this residues shows increased binding with Bcl9 (mouse homologue Bcl9-2) PMID:15371335 Apperently Bcl9 binds b-catenin independently of Y142 PMID:17113272 s_wnc4_re26(MAP:survival): In airway smooth muscle cells PMID:21908588 References_end</body> </html> </notes> <label text="WNT canonical pathway nucleus"/> <bbox w="80.0" h="30.0" x="10268.0" y="3567.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc4_s140_wnc1_wnc4_sa110" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19928350, PMID:22898821, PMID:17293347 References_end</body> </html> </notes> <label text="Microtubele polymerisation"/> <bbox w="80.0" h="30.0" x="10892.0" y="3238.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc4_s134_wnc1_wnc4_sa104" compartmentRef="wnc1_wnc4_c1_wnc1_wnc4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re33:(MAP:survival) PMID:18285450 References_end</body> </html> </notes> <label text="Tight junctions"/> <bbox w="80.0" h="30.0" x="9911.0" y="3864.0"/> </glyph> <glyph class="phenotype" id="wnc1_s_wnc4_s59_wnc1_wnc4_sa39" compartmentRef="wnc1_wnc4_c2_wnc1_wnc4_ca2"> <label text="Cell cycle pathway"/> <bbox w="80.0" h="30.0" x="10740.0" y="4263.0"/> </glyph> <glyph class="complex" id="wnc1_s1088_wnc1_wnc1_csa81" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PKA_C*:PKA_R* Identifiers_end</body> </html> </notes> <label text="(PKA)"/> <clone/> <bbox w="123.0" h="94.0" x="8897.0" y="755.0"/> <glyph class="macromolecule" id="wnc1_s1089_wnc1_wnc1_sa728"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: protein kinase AMP-activated beta 1 non-catalytic subunit HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478 GENECARDS:PRKAB1 REACTOME:49384 KEGG:5564 ATLASONC:PRKAB1ID44100ch12q24 WIKI:PRKAB1 protein kinase AMP-activated beta 2 non-catalytic subunit HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741 GENECARDS:PRKAB2 REACTOME:49386 ATLASONC:GC_PRKAB2 WIKI:PRKAB2 protein kinase AMP-activated gamma 1 non-catalytic subunit HUGO:PRKAG1 HGNC:9385 ENTREZ:5571 UNIPROT:P54619 GENECARDS:PRKAG1 REACTOME:49388 KEGG:5571 ATLASONC:GC_PRKAG1 WIKI:PRKAG1 protein kinase AMP-activated gamma 2 non-catalytic subunit HUGO:PRKAG2 HGNC:9386 ENTREZ:51422 UNIPROT:Q9UGJ0 GENECARDS:PRKAG2 REACTOME:49390 KEGG:51422 ATLASONC:GC_PRKAG2 WIKI:PRKAG2 HUGO:PRKAG3 HGNC:9387 ENTREZ:53632 UNIPROT:Q9UGI9 GENECARDS:PRKAG3 REACTOME:49392 KEGG:53632 ATLASONC:GC_PRKAG3 WIKI:PRKAG3 protein kinase cAMP-dependent regulatory type I alpha HUGO:PRKAR1A HGNC:9388 ENTREZ:5573 UNIPROT:P10644 GENECARDS:PRKAR1A REACTOME:57837 KEGG:5573 ATLASONC:PRKAR1AID387 WIKI:PRKAR1A protein kinase cAMP-dependent regulatory type I beta HUGO:PRKAR1B HGNC:9390 ENTREZ:5575 UNIPROT:P31321 GENECARDS:PRKAR1B REACTOME:57839 KEGG:5575 ATLASONC:GC_PRKAR1B WIKI:PRKAR1B protein kinase cAMP-dependent regulatory type II alpha HUGO:PRKAR2A HGNC:9391 ENTREZ:5576 UNIPROT:P13861 GENECARDS:PRKAR2A REACTOME:57841 KEGG:5576 ATLASONC:GC_PRKAR2A WIKI:PRKAR2A protein kinase cAMP-dependent regulatory type II beta HUGO:PRKAR2B HGNC:9392 ENTREZ:5577 UNIPROT:P31323 GENECARDS:PRKAR2B REACTOME:57843 KEGG:5577 ATLASONC:GC_PRKAR2B WIKI:PRKAR2B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: protein kinase AMP-activated beta 1 non-catalytic subunit HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478 GENECARDS:PRKAB1 REACTOME:49384 KEGG:5564 ATLASONC:PRKAB1ID44100ch12q24 WIKI:PRKAB1 protein kinase AMP-activated beta 2 non-catalytic subunit HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741 GENECARDS:PRKAB2 REACTOME:49386 ATLASONC:GC_PRKAB2 WIKI:PRKAB2 protein kinase AMP-activated gamma 1 non-catalytic subunit HUGO:PRKAG1 HGNC:9385 ENTREZ:5571 UNIPROT:P54619 GENECARDS:PRKAG1 REACTOME:49388 KEGG:5571 ATLASONC:GC_PRKAG1 WIKI:PRKAG1 protein kinase AMP-activated gamma 2 non-catalytic subunit HUGO:PRKAG2 HGNC:9386 ENTREZ:51422 UNIPROT:Q9UGJ0 GENECARDS:PRKAG2 REACTOME:49390 KEGG:51422 ATLASONC:GC_PRKAG2 WIKI:PRKAG2 HUGO:PRKAG3 HGNC:9387 ENTREZ:53632 UNIPROT:Q9UGI9 GENECARDS:PRKAG3 REACTOME:49392 KEGG:53632 ATLASONC:GC_PRKAG3 WIKI:PRKAG3 protein kinase cAMP-dependent regulatory type I alpha HUGO:PRKAR1A HGNC:9388 ENTREZ:5573 UNIPROT:P10644 GENECARDS:PRKAR1A REACTOME:57837 KEGG:5573 ATLASONC:PRKAR1AID387 WIKI:PRKAR1A protein kinase cAMP-dependent regulatory type I beta HUGO:PRKAR1B HGNC:9390 ENTREZ:5575 UNIPROT:P31321 GENECARDS:PRKAR1B REACTOME:57839 KEGG:5575 ATLASONC:GC_PRKAR1B WIKI:PRKAR1B protein kinase cAMP-dependent regulatory type II alpha HUGO:PRKAR2A HGNC:9391 ENTREZ:5576 UNIPROT:P13861 GENECARDS:PRKAR2A REACTOME:57841 KEGG:5576 ATLASONC:GC_PRKAR2A WIKI:PRKAR2A protein kinase cAMP-dependent regulatory type II beta HUGO:PRKAR2B HGNC:9392 ENTREZ:5577 UNIPROT:P31323 GENECARDS:PRKAR2B REACTOME:57843 KEGG:5577 ATLASONC:GC_PRKAR2B WIKI:PRKAR2B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PKA_R*"/> <clone/> <bbox w="45.0" h="25.0" x="8911.0" y="770.5"/> </glyph> <glyph class="macromolecule" id="wnc1_s1090_wnc1_wnc1_sa729"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: HUGO:PRKAA1 HGNC:9376 ENTREZ:5562 UNIPROT:Q13131 GENECARDS:PRKAA1 REACTOME:49380 KEGG:5562 ATLASONC:GC_PRKAA1 WIKI:PRKAA1 HUGO:PRKAA2 HGNC:9377 ENTREZ:5563 UNIPROT:P54646 GENECARDS:PRKAA2 REACTOME:49382 KEGG:5563 ATLASONC:GC_PRKAA2 WIKI:PRKAA2 HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 GENECARDS:PRKACG REACTOME:57849 KEGG:5568 ATLASONC:GC_PRKACG WIKI:PRKACG Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: HUGO:PRKAA1 HGNC:9376 ENTREZ:5562 UNIPROT:Q13131 GENECARDS:PRKAA1 REACTOME:49380 KEGG:5562 ATLASONC:GC_PRKAA1 WIKI:PRKAA1 HUGO:PRKAA2 HGNC:9377 ENTREZ:5563 UNIPROT:P54646 GENECARDS:PRKAA2 REACTOME:49382 KEGG:5563 ATLASONC:GC_PRKAA2 WIKI:PRKAA2 HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 GENECARDS:PRKACG REACTOME:57849 KEGG:5568 ATLASONC:GC_PRKACG WIKI:PRKACG Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PKA_C*"/> <clone/> <bbox w="45.0" h="25.0" x="8911.0" y="799.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s1089_wnc1_wnc1_sa730"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: protein kinase AMP-activated beta 1 non-catalytic subunit HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478 GENECARDS:PRKAB1 REACTOME:49384 KEGG:5564 ATLASONC:PRKAB1ID44100ch12q24 WIKI:PRKAB1 protein kinase AMP-activated beta 2 non-catalytic subunit HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741 GENECARDS:PRKAB2 REACTOME:49386 ATLASONC:GC_PRKAB2 WIKI:PRKAB2 protein kinase AMP-activated gamma 1 non-catalytic subunit HUGO:PRKAG1 HGNC:9385 ENTREZ:5571 UNIPROT:P54619 GENECARDS:PRKAG1 REACTOME:49388 KEGG:5571 ATLASONC:GC_PRKAG1 WIKI:PRKAG1 protein kinase AMP-activated gamma 2 non-catalytic subunit HUGO:PRKAG2 HGNC:9386 ENTREZ:51422 UNIPROT:Q9UGJ0 GENECARDS:PRKAG2 REACTOME:49390 KEGG:51422 ATLASONC:GC_PRKAG2 WIKI:PRKAG2 HUGO:PRKAG3 HGNC:9387 ENTREZ:53632 UNIPROT:Q9UGI9 GENECARDS:PRKAG3 REACTOME:49392 KEGG:53632 ATLASONC:GC_PRKAG3 WIKI:PRKAG3 protein kinase cAMP-dependent regulatory type I alpha HUGO:PRKAR1A HGNC:9388 ENTREZ:5573 UNIPROT:P10644 GENECARDS:PRKAR1A REACTOME:57837 KEGG:5573 ATLASONC:PRKAR1AID387 WIKI:PRKAR1A protein kinase cAMP-dependent regulatory type I beta HUGO:PRKAR1B HGNC:9390 ENTREZ:5575 UNIPROT:P31321 GENECARDS:PRKAR1B REACTOME:57839 KEGG:5575 ATLASONC:GC_PRKAR1B WIKI:PRKAR1B protein kinase cAMP-dependent regulatory type II alpha HUGO:PRKAR2A HGNC:9391 ENTREZ:5576 UNIPROT:P13861 GENECARDS:PRKAR2A REACTOME:57841 KEGG:5576 ATLASONC:GC_PRKAR2A WIKI:PRKAR2A protein kinase cAMP-dependent regulatory type II beta HUGO:PRKAR2B HGNC:9392 ENTREZ:5577 UNIPROT:P31323 GENECARDS:PRKAR2B REACTOME:57843 KEGG:5577 ATLASONC:GC_PRKAR2B WIKI:PRKAR2B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: protein kinase AMP-activated beta 1 non-catalytic subunit HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478 GENECARDS:PRKAB1 REACTOME:49384 KEGG:5564 ATLASONC:PRKAB1ID44100ch12q24 WIKI:PRKAB1 protein kinase AMP-activated beta 2 non-catalytic subunit HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741 GENECARDS:PRKAB2 REACTOME:49386 ATLASONC:GC_PRKAB2 WIKI:PRKAB2 protein kinase AMP-activated gamma 1 non-catalytic subunit HUGO:PRKAG1 HGNC:9385 ENTREZ:5571 UNIPROT:P54619 GENECARDS:PRKAG1 REACTOME:49388 KEGG:5571 ATLASONC:GC_PRKAG1 WIKI:PRKAG1 protein kinase AMP-activated gamma 2 non-catalytic subunit HUGO:PRKAG2 HGNC:9386 ENTREZ:51422 UNIPROT:Q9UGJ0 GENECARDS:PRKAG2 REACTOME:49390 KEGG:51422 ATLASONC:GC_PRKAG2 WIKI:PRKAG2 HUGO:PRKAG3 HGNC:9387 ENTREZ:53632 UNIPROT:Q9UGI9 GENECARDS:PRKAG3 REACTOME:49392 KEGG:53632 ATLASONC:GC_PRKAG3 WIKI:PRKAG3 protein kinase cAMP-dependent regulatory type I alpha HUGO:PRKAR1A HGNC:9388 ENTREZ:5573 UNIPROT:P10644 GENECARDS:PRKAR1A REACTOME:57837 KEGG:5573 ATLASONC:PRKAR1AID387 WIKI:PRKAR1A protein kinase cAMP-dependent regulatory type I beta HUGO:PRKAR1B HGNC:9390 ENTREZ:5575 UNIPROT:P31321 GENECARDS:PRKAR1B REACTOME:57839 KEGG:5575 ATLASONC:GC_PRKAR1B WIKI:PRKAR1B protein kinase cAMP-dependent regulatory type II alpha HUGO:PRKAR2A HGNC:9391 ENTREZ:5576 UNIPROT:P13861 GENECARDS:PRKAR2A REACTOME:57841 KEGG:5576 ATLASONC:GC_PRKAR2A WIKI:PRKAR2A protein kinase cAMP-dependent regulatory type II beta HUGO:PRKAR2B HGNC:9392 ENTREZ:5577 UNIPROT:P31323 GENECARDS:PRKAR2B REACTOME:57843 KEGG:5577 ATLASONC:GC_PRKAR2B WIKI:PRKAR2B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PKA_R*"/> <clone/> <bbox w="45.0" h="25.0" x="8963.0" y="770.5"/> </glyph> <glyph class="macromolecule" id="wnc1_s1090_wnc1_wnc1_sa731"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: HUGO:PRKAA1 HGNC:9376 ENTREZ:5562 UNIPROT:Q13131 GENECARDS:PRKAA1 REACTOME:49380 KEGG:5562 ATLASONC:GC_PRKAA1 WIKI:PRKAA1 HUGO:PRKAA2 HGNC:9377 ENTREZ:5563 UNIPROT:P54646 GENECARDS:PRKAA2 REACTOME:49382 KEGG:5563 ATLASONC:GC_PRKAA2 WIKI:PRKAA2 HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 GENECARDS:PRKACG REACTOME:57849 KEGG:5568 ATLASONC:GC_PRKACG WIKI:PRKACG Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: HUGO:PRKAA1 HGNC:9376 ENTREZ:5562 UNIPROT:Q13131 GENECARDS:PRKAA1 REACTOME:49380 KEGG:5562 ATLASONC:GC_PRKAA1 WIKI:PRKAA1 HUGO:PRKAA2 HGNC:9377 ENTREZ:5563 UNIPROT:P54646 GENECARDS:PRKAA2 REACTOME:49382 KEGG:5563 ATLASONC:GC_PRKAA2 WIKI:PRKAA2 HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 GENECARDS:PRKACG REACTOME:57849 KEGG:5568 ATLASONC:GC_PRKACG WIKI:PRKACG Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PKA_C*"/> <clone/> <bbox w="45.0" h="25.0" x="8963.0" y="799.0"/> </glyph> </glyph> <glyph class="complex" id="wnc1_s1088_wnc1_wnc1_csa82" compartmentRef="wnc1_wnc1_c1_wnc1_wnc1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PKA_C*:PKA_R* Identifiers_end</body> </html> </notes> <label text="(PKA)"/> <clone/> <bbox w="123.0" h="94.0" x="8896.0" y="636.0"/> <glyph class="macromolecule" id="wnc1_s1089_wnc1_wnc1_sa732"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: protein kinase AMP-activated beta 1 non-catalytic subunit HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478 GENECARDS:PRKAB1 REACTOME:49384 KEGG:5564 ATLASONC:PRKAB1ID44100ch12q24 WIKI:PRKAB1 protein kinase AMP-activated beta 2 non-catalytic subunit HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741 GENECARDS:PRKAB2 REACTOME:49386 ATLASONC:GC_PRKAB2 WIKI:PRKAB2 protein kinase AMP-activated gamma 1 non-catalytic subunit HUGO:PRKAG1 HGNC:9385 ENTREZ:5571 UNIPROT:P54619 GENECARDS:PRKAG1 REACTOME:49388 KEGG:5571 ATLASONC:GC_PRKAG1 WIKI:PRKAG1 protein kinase AMP-activated gamma 2 non-catalytic subunit HUGO:PRKAG2 HGNC:9386 ENTREZ:51422 UNIPROT:Q9UGJ0 GENECARDS:PRKAG2 REACTOME:49390 KEGG:51422 ATLASONC:GC_PRKAG2 WIKI:PRKAG2 HUGO:PRKAG3 HGNC:9387 ENTREZ:53632 UNIPROT:Q9UGI9 GENECARDS:PRKAG3 REACTOME:49392 KEGG:53632 ATLASONC:GC_PRKAG3 WIKI:PRKAG3 protein kinase cAMP-dependent regulatory type I alpha HUGO:PRKAR1A HGNC:9388 ENTREZ:5573 UNIPROT:P10644 GENECARDS:PRKAR1A REACTOME:57837 KEGG:5573 ATLASONC:PRKAR1AID387 WIKI:PRKAR1A protein kinase cAMP-dependent regulatory type I beta HUGO:PRKAR1B HGNC:9390 ENTREZ:5575 UNIPROT:P31321 GENECARDS:PRKAR1B REACTOME:57839 KEGG:5575 ATLASONC:GC_PRKAR1B WIKI:PRKAR1B protein kinase cAMP-dependent regulatory type II alpha HUGO:PRKAR2A HGNC:9391 ENTREZ:5576 UNIPROT:P13861 GENECARDS:PRKAR2A REACTOME:57841 KEGG:5576 ATLASONC:GC_PRKAR2A WIKI:PRKAR2A protein kinase cAMP-dependent regulatory type II beta HUGO:PRKAR2B HGNC:9392 ENTREZ:5577 UNIPROT:P31323 GENECARDS:PRKAR2B REACTOME:57843 KEGG:5577 ATLASONC:GC_PRKAR2B WIKI:PRKAR2B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: protein kinase AMP-activated beta 1 non-catalytic subunit HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478 GENECARDS:PRKAB1 REACTOME:49384 KEGG:5564 ATLASONC:PRKAB1ID44100ch12q24 WIKI:PRKAB1 protein kinase AMP-activated beta 2 non-catalytic subunit HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741 GENECARDS:PRKAB2 REACTOME:49386 ATLASONC:GC_PRKAB2 WIKI:PRKAB2 protein kinase AMP-activated gamma 1 non-catalytic subunit HUGO:PRKAG1 HGNC:9385 ENTREZ:5571 UNIPROT:P54619 GENECARDS:PRKAG1 REACTOME:49388 KEGG:5571 ATLASONC:GC_PRKAG1 WIKI:PRKAG1 protein kinase AMP-activated gamma 2 non-catalytic subunit HUGO:PRKAG2 HGNC:9386 ENTREZ:51422 UNIPROT:Q9UGJ0 GENECARDS:PRKAG2 REACTOME:49390 KEGG:51422 ATLASONC:GC_PRKAG2 WIKI:PRKAG2 HUGO:PRKAG3 HGNC:9387 ENTREZ:53632 UNIPROT:Q9UGI9 GENECARDS:PRKAG3 REACTOME:49392 KEGG:53632 ATLASONC:GC_PRKAG3 WIKI:PRKAG3 protein kinase cAMP-dependent regulatory type I alpha HUGO:PRKAR1A HGNC:9388 ENTREZ:5573 UNIPROT:P10644 GENECARDS:PRKAR1A REACTOME:57837 KEGG:5573 ATLASONC:PRKAR1AID387 WIKI:PRKAR1A protein kinase cAMP-dependent regulatory type I beta HUGO:PRKAR1B HGNC:9390 ENTREZ:5575 UNIPROT:P31321 GENECARDS:PRKAR1B REACTOME:57839 KEGG:5575 ATLASONC:GC_PRKAR1B WIKI:PRKAR1B protein kinase cAMP-dependent regulatory type II alpha HUGO:PRKAR2A HGNC:9391 ENTREZ:5576 UNIPROT:P13861 GENECARDS:PRKAR2A REACTOME:57841 KEGG:5576 ATLASONC:GC_PRKAR2A WIKI:PRKAR2A protein kinase cAMP-dependent regulatory type II beta HUGO:PRKAR2B HGNC:9392 ENTREZ:5577 UNIPROT:P31323 GENECARDS:PRKAR2B REACTOME:57843 KEGG:5577 ATLASONC:GC_PRKAR2B WIKI:PRKAR2B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PKA_R*"/> <clone/> <bbox w="45.0" h="25.0" x="8910.0" y="651.5"/> </glyph> <glyph class="macromolecule" id="wnc1_s1090_wnc1_wnc1_sa733"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: HUGO:PRKAA1 HGNC:9376 ENTREZ:5562 UNIPROT:Q13131 GENECARDS:PRKAA1 REACTOME:49380 KEGG:5562 ATLASONC:GC_PRKAA1 WIKI:PRKAA1 HUGO:PRKAA2 HGNC:9377 ENTREZ:5563 UNIPROT:P54646 GENECARDS:PRKAA2 REACTOME:49382 KEGG:5563 ATLASONC:GC_PRKAA2 WIKI:PRKAA2 HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 GENECARDS:PRKACG REACTOME:57849 KEGG:5568 ATLASONC:GC_PRKACG WIKI:PRKACG Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: HUGO:PRKAA1 HGNC:9376 ENTREZ:5562 UNIPROT:Q13131 GENECARDS:PRKAA1 REACTOME:49380 KEGG:5562 ATLASONC:GC_PRKAA1 WIKI:PRKAA1 HUGO:PRKAA2 HGNC:9377 ENTREZ:5563 UNIPROT:P54646 GENECARDS:PRKAA2 REACTOME:49382 KEGG:5563 ATLASONC:GC_PRKAA2 WIKI:PRKAA2 HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 GENECARDS:PRKACG REACTOME:57849 KEGG:5568 ATLASONC:GC_PRKACG WIKI:PRKACG Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PKA_C*"/> <clone/> <bbox w="45.0" h="25.0" x="8910.0" y="680.0"/> </glyph> <glyph class="macromolecule" id="wnc1_s1089_wnc1_wnc1_sa734"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: protein kinase AMP-activated beta 1 non-catalytic subunit HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478 GENECARDS:PRKAB1 REACTOME:49384 KEGG:5564 ATLASONC:PRKAB1ID44100ch12q24 WIKI:PRKAB1 protein kinase AMP-activated beta 2 non-catalytic subunit HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741 GENECARDS:PRKAB2 REACTOME:49386 ATLASONC:GC_PRKAB2 WIKI:PRKAB2 protein kinase AMP-activated gamma 1 non-catalytic subunit HUGO:PRKAG1 HGNC:9385 ENTREZ:5571 UNIPROT:P54619 GENECARDS:PRKAG1 REACTOME:49388 KEGG:5571 ATLASONC:GC_PRKAG1 WIKI:PRKAG1 protein kinase AMP-activated gamma 2 non-catalytic subunit HUGO:PRKAG2 HGNC:9386 ENTREZ:51422 UNIPROT:Q9UGJ0 GENECARDS:PRKAG2 REACTOME:49390 KEGG:51422 ATLASONC:GC_PRKAG2 WIKI:PRKAG2 HUGO:PRKAG3 HGNC:9387 ENTREZ:53632 UNIPROT:Q9UGI9 GENECARDS:PRKAG3 REACTOME:49392 KEGG:53632 ATLASONC:GC_PRKAG3 WIKI:PRKAG3 protein kinase cAMP-dependent regulatory type I alpha HUGO:PRKAR1A HGNC:9388 ENTREZ:5573 UNIPROT:P10644 GENECARDS:PRKAR1A REACTOME:57837 KEGG:5573 ATLASONC:PRKAR1AID387 WIKI:PRKAR1A protein kinase cAMP-dependent regulatory type I beta HUGO:PRKAR1B HGNC:9390 ENTREZ:5575 UNIPROT:P31321 GENECARDS:PRKAR1B REACTOME:57839 KEGG:5575 ATLASONC:GC_PRKAR1B WIKI:PRKAR1B protein kinase cAMP-dependent regulatory type II alpha HUGO:PRKAR2A HGNC:9391 ENTREZ:5576 UNIPROT:P13861 GENECARDS:PRKAR2A REACTOME:57841 KEGG:5576 ATLASONC:GC_PRKAR2A WIKI:PRKAR2A protein kinase cAMP-dependent regulatory type II beta HUGO:PRKAR2B HGNC:9392 ENTREZ:5577 UNIPROT:P31323 GENECARDS:PRKAR2B REACTOME:57843 KEGG:5577 ATLASONC:GC_PRKAR2B WIKI:PRKAR2B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: protein kinase AMP-activated beta 1 non-catalytic subunit HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478 GENECARDS:PRKAB1 REACTOME:49384 KEGG:5564 ATLASONC:PRKAB1ID44100ch12q24 WIKI:PRKAB1 protein kinase AMP-activated beta 2 non-catalytic subunit HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741 GENECARDS:PRKAB2 REACTOME:49386 ATLASONC:GC_PRKAB2 WIKI:PRKAB2 protein kinase AMP-activated gamma 1 non-catalytic subunit HUGO:PRKAG1 HGNC:9385 ENTREZ:5571 UNIPROT:P54619 GENECARDS:PRKAG1 REACTOME:49388 KEGG:5571 ATLASONC:GC_PRKAG1 WIKI:PRKAG1 protein kinase AMP-activated gamma 2 non-catalytic subunit HUGO:PRKAG2 HGNC:9386 ENTREZ:51422 UNIPROT:Q9UGJ0 GENECARDS:PRKAG2 REACTOME:49390 KEGG:51422 ATLASONC:GC_PRKAG2 WIKI:PRKAG2 HUGO:PRKAG3 HGNC:9387 ENTREZ:53632 UNIPROT:Q9UGI9 GENECARDS:PRKAG3 REACTOME:49392 KEGG:53632 ATLASONC:GC_PRKAG3 WIKI:PRKAG3 protein kinase cAMP-dependent regulatory type I alpha HUGO:PRKAR1A HGNC:9388 ENTREZ:5573 UNIPROT:P10644 GENECARDS:PRKAR1A REACTOME:57837 KEGG:5573 ATLASONC:PRKAR1AID387 WIKI:PRKAR1A protein kinase cAMP-dependent regulatory type I beta HUGO:PRKAR1B HGNC:9390 ENTREZ:5575 UNIPROT:P31321 GENECARDS:PRKAR1B REACTOME:57839 KEGG:5575 ATLASONC:GC_PRKAR1B WIKI:PRKAR1B protein kinase cAMP-dependent regulatory type II alpha HUGO:PRKAR2A HGNC:9391 ENTREZ:5576 UNIPROT:P13861 GENECARDS:PRKAR2A REACTOME:57841 KEGG:5576 ATLASONC:GC_PRKAR2A WIKI:PRKAR2A protein kinase cAMP-dependent regulatory type II beta HUGO:PRKAR2B HGNC:9392 ENTREZ:5577 UNIPROT:P31323 GENECARDS:PRKAR2B REACTOME:57843 KEGG:5577 ATLASONC:GC_PRKAR2B WIKI:PRKAR2B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PKA_R*"/> <clone/> <bbox w="45.0" h="25.0" x="8962.0" y="651.5"/> </glyph> <glyph class="macromolecule" id="wnc1_s1090_wnc1_wnc1_sa735"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: HUGO:PRKAA1 HGNC:9376 ENTREZ:5562 UNIPROT:Q13131 GENECARDS:PRKAA1 REACTOME:49380 KEGG:5562 ATLASONC:GC_PRKAA1 WIKI:PRKAA1 HUGO:PRKAA2 HGNC:9377 ENTREZ:5563 UNIPROT:P54646 GENECARDS:PRKAA2 REACTOME:49382 KEGG:5563 ATLASONC:GC_PRKAA2 WIKI:PRKAA2 HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 GENECARDS:PRKACG REACTOME:57849 KEGG:5568 ATLASONC:GC_PRKACG WIKI:PRKACG Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: HUGO:PRKAA1 HGNC:9376 ENTREZ:5562 UNIPROT:Q13131 GENECARDS:PRKAA1 REACTOME:49380 KEGG:5562 ATLASONC:GC_PRKAA1 WIKI:PRKAA1 HUGO:PRKAA2 HGNC:9377 ENTREZ:5563 UNIPROT:P54646 GENECARDS:PRKAA2 REACTOME:49382 KEGG:5563 ATLASONC:GC_PRKAA2 WIKI:PRKAA2 HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 GENECARDS:PRKACG REACTOME:57849 KEGG:5568 ATLASONC:GC_PRKACG WIKI:PRKACG Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PKA_C*"/> <clone/> <bbox w="45.0" h="25.0" x="8962.0" y="680.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s108_wca1_wca1_csa16" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PPP1C*:PPP1R* Identifiers_end References_begin: s_wca1_re19:(MAP:survival) PMID:17318175 s_wca1_re16:(MAP:survival) PMID:17318175 PMID:19581931 References_end</body> </html> </notes> <label text="PPP1C*:PPP1R*"/> <bbox w="99.0" h="115.0" x="12781.0" y="540.5"/> <glyph class="macromolecule" id="wca1_wca1_s104_wca1_wca1_sa84"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Protein phosphatase 1 catalytic subunit alpha isozyme HUGO:PPP1CA HGNC:9281 ENTREZ:5499 UNIPROT:P62136 GENECARDS:PPP1CA REACTOME:61996 KEGG:5499 ATLASONC:GC_PPP1CA WIKI:PPP1CA Protein phosphatase 1 catalytic subunit beta isozyme HUGO:PPP1CB HGNC:9282 ENTREZ:5500 UNIPROT:P62140 GENECARDS:PPP1CB REACTOME:62004 KEGG:5500 ATLASONC:GC_PPP1CB WIKI:PPP1CB Protein phosphatase 1 catalytic subunit gamma isozyme HUGO:PPP1CC HGNC:9283 ENTREZ:5501 UNIPROT:P36873 GENECARDS:PPP1CC REACTOME:62014 KEGG:5501 ATLASONC:GC_PPP1CC WIKI:PPP1CC Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:RB MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20399103 References_end</body> </html> </notes> <label text="PPP1C*"/> <bbox w="80.0" h="40.0" x="12790.0" y="551.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s105_wca1_wca1_sa85"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 1 regulatory (inhibitor) subunit 1A HUGO:PPP1R1A HGNC:9286 ENTREZ:5502 UNIPROT:Q13522 GENECARDS:PPP1R1A KEGG:5502 ATLASONC:GC_PPP1R1A WIKI:PPP1R1A protein phosphatase 1 regulatory (inhibitor) subunit 1B HUGO:PPP1R1B HGNC:9287 ENTREZ:84152 UNIPROT:Q9UD71 GENECARDS:PPP1R1B REACTOME:57451 KEGG:84152 ATLASONC:PPP1R1BID44096ch17q12 WIKI:PPP1R1B protein phosphatase 1 regulatory (inhibitor) subunit 1C HUGO:PPP1R1C HGNC:14940 ENTREZ:151242 UNIPROT:Q8WVI7 GENECARDS:PPP1R1C KEGG:151242 ATLASONC:GC_PPP1R1C WIKI:PPP1R1C protein phosphatase 1 regulatory (inhibitor) subunit 2 HUGO:PPP1R2 HGNC:9288 ENTREZ:5504 UNIPROT:P41236 GENECARDS:PPP1R2 KEGG:5504 ATLASONC:GC_PPP1R2 WIKI:PPP1R2 protein phosphatase 1 regulatory subunit 3A HUGO:PPP1R3A HGNC:9291 ENTREZ:5506 UNIPROT:Q16821 GENECARDS:PPP1R3A KEGG:5506 ATLASONC:GC_PPP1R3A WIKI:PPP1R3A protein phosphatase 1 regulatory subunit 3B HUGO:PPP1R3B HGNC:14942 ENTREZ:79660 UNIPROT:Q86XI6 GENECARDS:PPP1R3B KEGG:79660 ATLASONC:GC_PPP1R3B WIKI:PPP1R3B protein phosphatase 1 regulatory subunit 3C HUGO:PPP1R3C HGNC:9293 ENTREZ:5507 UNIPROT:Q9UQK1 GENECARDS:PPP1R3C KEGG:5507 ATLASONC:GC_PPP1R3C WIKI:PPP1R3C protein phosphatase 1 regulatory (inhibitor) subunit 3D HUGO:PPP1R3D HGNC:9294 ENTREZ:5509 UNIPROT:O95685 GENECARDS:PPP1R3D KEGG:5509 ATLASONC:GC_PPP1R3D WIKI:PPP1R3D protein phosphatase 1 regulatory subunit 3E HUGO:PPP1R3E HGNC:14943 ENTREZ:90673 UNIPROT:Q9H7J1 GENECARDS:PPP1R3E ATLASONC:GC_PPP1R3E WIKI:PPP1R3E protein phosphatase 1 regulatory subunit 3F HUGO:PPP1R3F HGNC:14944 ENTREZ:89801 UNIPROT:Q6ZSY5 GENECARDS:PPP1R3F KEGG:89801 ATLASONC:GC_PPP1R3F WIKI:PPP1R3F protein phosphatase 1 regulatory subunit 3G HUGO:PPP1R3G HGNC:14945 ENTREZ:648791 UNIPROT:B7ZBB8 GENECARDS:PPP1R3G ATLASONC:GC_PPP1R3G WIKI:PPP1R3G protein phosphatase 1 regulatory subunit 7 HUGO:PPP1R7 HGNC:9295 ENTREZ:5510 UNIPROT:Q15435 GENECARDS:PPP1R7 KEGG:5510 ATLASONC:GC_PPP1R7 WIKI:PPP1R7 protein phosphatase 1 regulatory subunit 8 HUGO:PPP1R8 HGNC:9296 ENTREZ:5511 UNIPROT:Q12972 GENECARDS:PPP1R8 KEGG:5511 ATLASONC:PPP1R8ID41811ch1p35 WIKI:PPP1R8 protein phosphatase 1 regulatory subunit 9A HUGO:PPP1R9A HGNC:14946 ENTREZ:55607 UNIPROT:Q9ULJ8 GENECARDS:PPP1R9A KEGG:55607 ATLASONC:GC_PPP1R9A WIKI:PPP1R9A protein phosphatase 1 regulatory subunit 9B HUGO:PPP1R9B HGNC:9298 ENTREZ:84687 UNIPROT:Q96SB3 GENECARDS:PPP1R9B KEGG:84687 ATLASONC:PPP1R9BID51558ch17q21 WIKI:PPP1R9B protein phosphatase 1 regulatory subunit 10 HUGO:PPP1R10 HGNC:9284 ENTREZ:5514 UNIPROT:Q96QC0 GENECARDS:PPP1R10 KEGG:5514 ATLASONC:GC_PPP1R10 WIKI:PPP1R10 protein phosphatase 1 regulatory (inhibitor) subunit 11 HUGO:PPP1R11 HGNC:9285 ENTREZ:6992 UNIPROT:O60927 GENECARDS:PPP1R11 KEGG:6992 ATLASONC:GC_PPP1R11 WIKI:PPP1R11 protein phosphatase 1 regulatory subunit 12A HUGO:PPP1R12A HGNC:7618 ENTREZ:4659 UNIPROT:O14974 GENECARDS:PPP1R12A REACTOME:150515 KEGG:4659 ATLASONC:GC_PPP1R12A WIKI:PPP1R12A protein phosphatase 1 regulatory subunit 12B HUGO:PPP1R12B HGNC:7619 ENTREZ:4660 UNIPROT:O60237 GENECARDS:PPP1R12B REACTOME:150526 KEGG:4660 ATLASONC:GC_PPP1R12B WIKI:PPP1R12B protein phosphatase 1 regulatory subunit 12C HUGO:PPP1R12C HGNC:14947 ENTREZ:54776 UNIPROT:Q9BZL4 GENECARDS:PPP1R12C KEGG:54776 ATLASONC:GC_PPP1R12C WIKI:PPP1R12C protein phosphatase 1 regulatory subunit 13B HUGO:PPP1R13B HGNC:14950 ENTREZ:23368 UNIPROT:Q96KQ4 GENECARDS:PPP1R13B KEGG:23368 ATLASONC:GC_PPP1R13B WIKI:PPP1R13B protein phosphatase 1 regulatory (inhibitor) subunit 14A HUGO:PPP1R14A HGNC:14871 ENTREZ:94274 UNIPROT:Q96A00 GENECARDS:PPP1R14A KEGG:94274 ATLASONC:GC_PPP1R14A WIKI:PPP1R14A protein phosphatase 1 regulatory (inhibitor) subunit 14B HUGO:PPP1R14B HGNC:9057 ENTREZ:26472 UNIPROT:Q96C90 GENECARDS:PPP1R14B KEGG:26472 ATLASONC:GC_PPP1R14B WIKI:PPP1R14B protein phosphatase 1 regulatory (inhibitor) subunit 14C HUGO:PPP1R14C HGNC:14952 ENTREZ:81706 UNIPROT:Q8TAE6 GENECARDS:PPP1R14C KEGG:81706 ATLASONC:GC_PPP1R14C WIKI:PPP1R14C protein phosphatase 1 regulatory (inhibitor) subunit 14D HUGO:PPP1R14D HGNC:14953 ENTREZ:54866 UNIPROT:Q9NXH3 GENECARDS:PPP1R14D KEGG:54866 ATLASONC:GC_PPP1R14D WIKI:PPP1R14D protein phosphatase 1 regulatory subunit 15A HUGO:PPP1R15A HGNC:14375 ENTREZ:23645 UNIPROT:O75807 GENECARDS:PPP1R15A REACTOME:243750 KEGG:23645 ATLASONC:GC_PPP1R15A WIKI:PPP1R15A protein phosphatase 1 regulatory subunit 15B HUGO:PPP1R15B HGNC:14951 ENTREZ:84919 UNIPROT:Q5SWA1 GENECARDS:PPP1R15B KEGG:84919 ATLASONC:GC_PPP1R15B WIKI:PPP1R15B HUGO:PPP1R15A HGNC:14375 ENTREZ:23645 UNIPROT:O75807 GENECARDS:PPP1R15A REACTOME:243750 KEGG:23645 ATLASONC:GC_PPP1R15A WIKI:PPP1R15A protein phosphatase 1 regulatory subunit 16A HUGO:PPP1R16A HGNC:14941 ENTREZ:84988 UNIPROT:Q96I34 GENECARDS:PPP1R16A KEGG:84988 ATLASONC:GC_PPP1R16A WIKI:PPP1R16A protein phosphatase 1 regulatory subunit 16B HUGO:PPP1R16B HGNC:15850 ENTREZ:26051 UNIPROT:Q96T49 GENECARDS:PPP1R16B KEGG:26051 ATLASONC:GC_PPP1R16B WIKI:PPP1R16B protein phosphatase 1 regulatory subunit 17 HUGO:PPP1R17 HGNC:16973 ENTREZ:10842 UNIPROT:O96001 GENECARDS:PPP1R17 KEGG:10842 WIKI:PPP1R17 protein phosphatase 1 regulatory subunit 18 HUGO:PPP1R18 HGNC:29413 ENTREZ:170954 UNIPROT:Q6NYC8 GENECARDS:PPP1R18 KEGG:170954 WIKI:PPP1R18 protein phosphatase 1 regulatory subunit 21 HUGO:PPP1R21 HGNC:30595 ENTREZ:129285 UNIPROT:Q6ZMI0 GENECARDS:PPP1R21 KEGG:129285 WIKI:PPP1R21 protein phosphatase 1 regulatory subunit 26 HUGO:PPP1R26 HGNC:29089 ENTREZ:9858 UNIPROT:Q5T8A7 GENECARDS:PPP1R26 KEGG:9858 ATLASONC:GC_PPP1R26 WIKI:PPP1R26 protein phosphatase 1 regulatory subunit 27 HUGO:PPP1R27 HGNC:16813 ENTREZ:116729 UNIPROT:Q86WC6 GENECARDS:PPP1R27 KEGG:116729 WIKI:PPP1R27 protein phosphatase 1 regulatory subunit 32 HUGO:PPP1R32 HGNC:28869 ENTREZ:220004 UNIPROT:Q7Z5V6 GENECARDS:PPP1R32 KEGG:220004 WIKI:PPP1R32 protein phosphatase 1 regulatory subunit 35 HUGO:PPP1R35 HGNC:28320 ENTREZ:221908 UNIPROT:Q8TAP8 GENECARDS:PPP1R35 KEGG:221908 WIKI:PPP1R35 protein phosphatase 1 regulatory subunit 36 HUGO:PPP1R36 HGNC:20097 ENTREZ:145376 UNIPROT:Q96LQ0 GENECARDS:PPP1R36 KEGG:145376 WIKI:PPP1R36 protein phosphatase 1 regulatory subunit 37 HUGO:PPP1R37 HGNC:27607 ENTREZ:284352 UNIPROT:O75864 GENECARDS:PPP1R37 KEGG:284352 WIKI:PPP1R37 protein phosphatase 1 regulatory subunit 39 HUGO:PPP1R39 GENECARDS:PPP1R39 KEGG:153769 WIKI:PPP1R39 protein phosphatase 1 regulatory subunit 42 HUGO:PPP1R42 HGNC:33732 ENTREZ:286187 UNIPROT:Q7Z4L9 GENECARDS:PPP1R42 KEGG:286187 WIKI:PPP1R42 Identifiers_end Maps_Modules_begin: MAP:cellcycle / MODULE:RB MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20399103 References_end</body> </html> </notes> <label text="PPP1R*"/> <bbox w="80.0" h="40.0" x="12790.0" y="594.5"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s109_wca1_wca1_csa18" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC:AXIN*:CK1_alpha_*:GSK3*:PPP1C*:PPP1R* Identifiers_end References_begin: s_wca1_re19:(MAP:survival) PMID:17318175 References_end</body> </html> </notes> <label text="APC:AXIN*:CK1α*:GSK3*:PPP1C*:PPP1R*"/> <bbox w="196.0" h="166.0" x="12978.0" y="744.0"/> <glyph class="macromolecule" id="wca1_wca1_s115_wca1_wca1_sa100"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="13078.5" y="756.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s111_wca1_wca1_sa101"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 1 regulatory (inhibitor) subunit 1A HUGO:PPP1R1A HGNC:9286 ENTREZ:5502 UNIPROT:Q13522 GENECARDS:PPP1R1A KEGG:5502 ATLASONC:GC_PPP1R1A WIKI:PPP1R1A protein phosphatase 1 regulatory (inhibitor) subunit 1B HUGO:PPP1R1B HGNC:9287 ENTREZ:84152 UNIPROT:Q9UD71 GENECARDS:PPP1R1B REACTOME:57451 KEGG:84152 ATLASONC:PPP1R1BID44096ch17q12 WIKI:PPP1R1B protein phosphatase 1 regulatory (inhibitor) subunit 1C HUGO:PPP1R1C HGNC:14940 ENTREZ:151242 UNIPROT:Q8WVI7 GENECARDS:PPP1R1C KEGG:151242 ATLASONC:GC_PPP1R1C WIKI:PPP1R1C protein phosphatase 1 regulatory (inhibitor) subunit 2 HUGO:PPP1R2 HGNC:9288 ENTREZ:5504 UNIPROT:P41236 GENECARDS:PPP1R2 KEGG:5504 ATLASONC:GC_PPP1R2 WIKI:PPP1R2 protein phosphatase 1 regulatory subunit 3A HUGO:PPP1R3A HGNC:9291 ENTREZ:5506 UNIPROT:Q16821 GENECARDS:PPP1R3A KEGG:5506 ATLASONC:GC_PPP1R3A WIKI:PPP1R3A protein phosphatase 1 regulatory subunit 3B HUGO:PPP1R3B HGNC:14942 ENTREZ:79660 UNIPROT:Q86XI6 GENECARDS:PPP1R3B KEGG:79660 ATLASONC:GC_PPP1R3B WIKI:PPP1R3B protein phosphatase 1 regulatory subunit 3C HUGO:PPP1R3C HGNC:9293 ENTREZ:5507 UNIPROT:Q9UQK1 GENECARDS:PPP1R3C KEGG:5507 ATLASONC:GC_PPP1R3C WIKI:PPP1R3C protein phosphatase 1 regulatory (inhibitor) subunit 3D HUGO:PPP1R3D HGNC:9294 ENTREZ:5509 UNIPROT:O95685 GENECARDS:PPP1R3D KEGG:5509 ATLASONC:GC_PPP1R3D WIKI:PPP1R3D protein phosphatase 1 regulatory subunit 3E HUGO:PPP1R3E HGNC:14943 ENTREZ:90673 UNIPROT:Q9H7J1 GENECARDS:PPP1R3E ATLASONC:GC_PPP1R3E WIKI:PPP1R3E protein phosphatase 1 regulatory subunit 3F HUGO:PPP1R3F HGNC:14944 ENTREZ:89801 UNIPROT:Q6ZSY5 GENECARDS:PPP1R3F KEGG:89801 ATLASONC:GC_PPP1R3F WIKI:PPP1R3F protein phosphatase 1 regulatory subunit 3G HUGO:PPP1R3G HGNC:14945 ENTREZ:648791 UNIPROT:B7ZBB8 GENECARDS:PPP1R3G ATLASONC:GC_PPP1R3G WIKI:PPP1R3G protein phosphatase 1 regulatory subunit 7 HUGO:PPP1R7 HGNC:9295 ENTREZ:5510 UNIPROT:Q15435 GENECARDS:PPP1R7 KEGG:5510 ATLASONC:GC_PPP1R7 WIKI:PPP1R7 protein phosphatase 1 regulatory subunit 8 HUGO:PPP1R8 HGNC:9296 ENTREZ:5511 UNIPROT:Q12972 GENECARDS:PPP1R8 KEGG:5511 ATLASONC:PPP1R8ID41811ch1p35 WIKI:PPP1R8 protein phosphatase 1 regulatory subunit 9A HUGO:PPP1R9A HGNC:14946 ENTREZ:55607 UNIPROT:Q9ULJ8 GENECARDS:PPP1R9A KEGG:55607 ATLASONC:GC_PPP1R9A WIKI:PPP1R9A protein phosphatase 1 regulatory subunit 9B HUGO:PPP1R9B HGNC:9298 ENTREZ:84687 UNIPROT:Q96SB3 GENECARDS:PPP1R9B KEGG:84687 ATLASONC:PPP1R9BID51558ch17q21 WIKI:PPP1R9B protein phosphatase 1 regulatory subunit 10 HUGO:PPP1R10 HGNC:9284 ENTREZ:5514 UNIPROT:Q96QC0 GENECARDS:PPP1R10 KEGG:5514 ATLASONC:GC_PPP1R10 WIKI:PPP1R10 protein phosphatase 1 regulatory (inhibitor) subunit 11 HUGO:PPP1R11 HGNC:9285 ENTREZ:6992 UNIPROT:O60927 GENECARDS:PPP1R11 KEGG:6992 ATLASONC:GC_PPP1R11 WIKI:PPP1R11 protein phosphatase 1 regulatory subunit 12A HUGO:PPP1R12A HGNC:7618 ENTREZ:4659 UNIPROT:O14974 GENECARDS:PPP1R12A REACTOME:150515 KEGG:4659 ATLASONC:GC_PPP1R12A WIKI:PPP1R12A protein phosphatase 1 regulatory subunit 12B HUGO:PPP1R12B HGNC:7619 ENTREZ:4660 UNIPROT:O60237 GENECARDS:PPP1R12B REACTOME:150526 KEGG:4660 ATLASONC:GC_PPP1R12B WIKI:PPP1R12B protein phosphatase 1 regulatory subunit 12C HUGO:PPP1R12C HGNC:14947 ENTREZ:54776 UNIPROT:Q9BZL4 GENECARDS:PPP1R12C KEGG:54776 ATLASONC:GC_PPP1R12C WIKI:PPP1R12C protein phosphatase 1 regulatory subunit 13B HUGO:PPP1R13B HGNC:14950 ENTREZ:23368 UNIPROT:Q96KQ4 GENECARDS:PPP1R13B KEGG:23368 ATLASONC:GC_PPP1R13B WIKI:PPP1R13B protein phosphatase 1 regulatory (inhibitor) subunit 14A HUGO:PPP1R14A HGNC:14871 ENTREZ:94274 UNIPROT:Q96A00 GENECARDS:PPP1R14A KEGG:94274 ATLASONC:GC_PPP1R14A WIKI:PPP1R14A protein phosphatase 1 regulatory (inhibitor) subunit 14B HUGO:PPP1R14B HGNC:9057 ENTREZ:26472 UNIPROT:Q96C90 GENECARDS:PPP1R14B KEGG:26472 ATLASONC:GC_PPP1R14B WIKI:PPP1R14B protein phosphatase 1 regulatory (inhibitor) subunit 14C HUGO:PPP1R14C HGNC:14952 ENTREZ:81706 UNIPROT:Q8TAE6 GENECARDS:PPP1R14C KEGG:81706 ATLASONC:GC_PPP1R14C WIKI:PPP1R14C protein phosphatase 1 regulatory (inhibitor) subunit 14D HUGO:PPP1R14D HGNC:14953 ENTREZ:54866 UNIPROT:Q9NXH3 GENECARDS:PPP1R14D KEGG:54866 ATLASONC:GC_PPP1R14D WIKI:PPP1R14D protein phosphatase 1 regulatory subunit 15A HUGO:PPP1R15A HGNC:14375 ENTREZ:23645 UNIPROT:O75807 GENECARDS:PPP1R15A REACTOME:243750 KEGG:23645 ATLASONC:GC_PPP1R15A WIKI:PPP1R15A protein phosphatase 1 regulatory subunit 15B HUGO:PPP1R15B HGNC:14951 ENTREZ:84919 UNIPROT:Q5SWA1 GENECARDS:PPP1R15B KEGG:84919 ATLASONC:GC_PPP1R15B WIKI:PPP1R15B HUGO:PPP1R15A HGNC:14375 ENTREZ:23645 UNIPROT:O75807 GENECARDS:PPP1R15A REACTOME:243750 KEGG:23645 ATLASONC:GC_PPP1R15A WIKI:PPP1R15A protein phosphatase 1 regulatory subunit 16A HUGO:PPP1R16A HGNC:14941 ENTREZ:84988 UNIPROT:Q96I34 GENECARDS:PPP1R16A KEGG:84988 ATLASONC:GC_PPP1R16A WIKI:PPP1R16A protein phosphatase 1 regulatory subunit 16B HUGO:PPP1R16B HGNC:15850 ENTREZ:26051 UNIPROT:Q96T49 GENECARDS:PPP1R16B KEGG:26051 ATLASONC:GC_PPP1R16B WIKI:PPP1R16B protein phosphatase 1 regulatory subunit 17 HUGO:PPP1R17 HGNC:16973 ENTREZ:10842 UNIPROT:O96001 GENECARDS:PPP1R17 KEGG:10842 WIKI:PPP1R17 protein phosphatase 1 regulatory subunit 18 HUGO:PPP1R18 HGNC:29413 ENTREZ:170954 UNIPROT:Q6NYC8 GENECARDS:PPP1R18 KEGG:170954 WIKI:PPP1R18 protein phosphatase 1 regulatory subunit 21 HUGO:PPP1R21 HGNC:30595 ENTREZ:129285 UNIPROT:Q6ZMI0 GENECARDS:PPP1R21 KEGG:129285 WIKI:PPP1R21 protein phosphatase 1 regulatory subunit 26 HUGO:PPP1R26 HGNC:29089 ENTREZ:9858 UNIPROT:Q5T8A7 GENECARDS:PPP1R26 KEGG:9858 ATLASONC:GC_PPP1R26 WIKI:PPP1R26 protein phosphatase 1 regulatory subunit 27 HUGO:PPP1R27 HGNC:16813 ENTREZ:116729 UNIPROT:Q86WC6 GENECARDS:PPP1R27 KEGG:116729 WIKI:PPP1R27 protein phosphatase 1 regulatory subunit 32 HUGO:PPP1R32 HGNC:28869 ENTREZ:220004 UNIPROT:Q7Z5V6 GENECARDS:PPP1R32 KEGG:220004 WIKI:PPP1R32 protein phosphatase 1 regulatory subunit 35 HUGO:PPP1R35 HGNC:28320 ENTREZ:221908 UNIPROT:Q8TAP8 GENECARDS:PPP1R35 KEGG:221908 WIKI:PPP1R35 protein phosphatase 1 regulatory subunit 36 HUGO:PPP1R36 HGNC:20097 ENTREZ:145376 UNIPROT:Q96LQ0 GENECARDS:PPP1R36 KEGG:145376 WIKI:PPP1R36 protein phosphatase 1 regulatory subunit 37 HUGO:PPP1R37 HGNC:27607 ENTREZ:284352 UNIPROT:O75864 GENECARDS:PPP1R37 KEGG:284352 WIKI:PPP1R37 protein phosphatase 1 regulatory subunit 39 HUGO:PPP1R39 GENECARDS:PPP1R39 KEGG:153769 WIKI:PPP1R39 protein phosphatase 1 regulatory subunit 42 HUGO:PPP1R42 HGNC:33732 ENTREZ:286187 UNIPROT:Q7Z4L9 GENECARDS:PPP1R42 KEGG:286187 WIKI:PPP1R42 Identifiers_end Maps_Modules_begin: MAP:cellcycle / MODULE:RB MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20399103 References_end</body> </html> </notes> <label text="PPP1R*"/> <bbox w="80.0" h="40.0" x="13078.5" y="841.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s114_wca1_wca1_sa102"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="12994.0" y="756.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s117_wca1_wca1_sa103"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="12994.0" y="841.0"/> <glyph class="state variable" id="_73b96f1d-0bee-460d-bdd3-0ea121b83c12"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="13055.882" y="876.0"/> </glyph> <glyph class="state variable" id="_e7d09abb-267c-4dcb-b5c4-6472cfbb489c"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="12976.992" y="836.0"/> </glyph> <glyph class="state variable" id="_c64ad5d4-9f51-417e-8728-2efe297d5282"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="13056.5" y="836.2148"/> </glyph> <glyph class="state variable" id="_a6a53171-d090-4232-8f8c-73428a4678e3"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="13016.404" y="876.0"/> </glyph> <glyph class="state variable" id="_3f32693e-0138-4424-bcc6-30d0e417134e"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="13016.532" y="836.0"/> </glyph> <glyph class="state variable" id="_64a98e09-4149-4971-b174-7a38aacd1f2c"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="12976.5" y="875.7223"/> </glyph> <glyph class="state variable" id="_be45b1c3-c3ba-4940-b9d6-29a6156e9c29"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13069.0" y="836.0"/> </glyph> <glyph class="state variable" id="_6dbfe932-8d5c-4b97-9f35-a1952341ed5b"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="13056.5" y="875.1307"/> </glyph> <glyph class="state variable" id="_69abf9a1-775a-4b29-8cb0-3a9927f4713d"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="12976.5" y="875.7223"/> </glyph> <glyph class="state variable" id="_059fddfc-c949-4474-95f8-6c6719c95f3e"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12981.992" y="836.0"/> </glyph> <glyph class="state variable" id="_01406e4f-a5fe-44bc-b862-40c24f2f2269"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="12976.992" y="836.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s130_wca1_wca1_sa104"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="12994.0" y="799.0"/> <glyph class="state variable" id="_f6c5aef7-b9b7-4a35-b17e-0f179497477a"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="12981.992" y="794.0"/> </glyph> <glyph class="state variable" id="_1c340853-ef16-4d18-9235-fab779a5008f"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="13021.532" y="794.0"/> </glyph> <glyph class="state variable" id="_44101f02-657f-4615-95e8-56508343315e"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="13059.0" y="794.2148"/> </glyph> <glyph class="state variable" id="_974eda18-8155-40b7-b6a2-92eea668406e"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="13058.382" y="834.0"/> </glyph> <glyph class="state variable" id="_0b4268be-c53c-4dbc-82ff-46943a70182b"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="13018.904" y="834.0"/> </glyph> <glyph class="state variable" id="_e690f1d9-322b-4206-bfac-2dc8907991ac"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="12979.0" y="833.7223"/> </glyph> <glyph class="state variable" id="_8b95e7ca-ea4a-4528-961e-52f89fe43dce"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="13021.404" y="834.0"/> </glyph> <glyph class="state variable" id="_4991a8cc-f03e-4ba0-be0b-03d86d81efae"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="13060.882" y="834.0"/> </glyph> <glyph class="state variable" id="_d912d082-486b-44c9-9f02-428cf445d5b9"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="13066.5" y="794.2148"/> </glyph> <glyph class="state variable" id="_1cb1b46f-dfc2-4e67-8a51-03707dafb8d9"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12981.5" y="833.7223"/> </glyph> <glyph class="state variable" id="_16839d1c-217a-4001-baec-9698f4796a17"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12986.992" y="794.0"/> </glyph> <glyph class="state variable" id="_b1dda782-da48-434a-890a-701f8d326b46"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12989.0" y="794.0"/> </glyph> <glyph class="state variable" id="_3a3aa378-380b-4904-904c-72c3ea234cb0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13069.0" y="794.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s110_wca1_wca1_sa105"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Protein phosphatase 1 catalytic subunit alpha isozyme HUGO:PPP1CA HGNC:9281 ENTREZ:5499 UNIPROT:P62136 GENECARDS:PPP1CA REACTOME:61996 KEGG:5499 ATLASONC:GC_PPP1CA WIKI:PPP1CA Protein phosphatase 1 catalytic subunit beta isozyme HUGO:PPP1CB HGNC:9282 ENTREZ:5500 UNIPROT:P62140 GENECARDS:PPP1CB REACTOME:62004 KEGG:5500 ATLASONC:GC_PPP1CB WIKI:PPP1CB Protein phosphatase 1 catalytic subunit gamma isozyme HUGO:PPP1CC HGNC:9283 ENTREZ:5501 UNIPROT:P36873 GENECARDS:PPP1CC REACTOME:62014 KEGG:5501 ATLASONC:GC_PPP1CC WIKI:PPP1CC Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:RB MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20399103 References_end</body> </html> </notes> <label text="PPP1C*"/> <bbox w="80.0" h="40.0" x="13078.5" y="799.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s181_wca1_wca1_csa26" compartmentRef="wca1_wca1_c4_wca1_wca1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK1_epsilon_*:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:p120* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20940130 PMID:21606194 s_wca1_re25:(MAP:survival) PMID:21606194 PMID:19705439 s_wca1_re28(MAP:survival): PMID:20006983 PMID:16965538 PMID:210606194 PMID:20093472 PMID:21796133 Phosphorylation of DVL by CK1 epsilon. Activation of CK1 epsilon by unknown factor An acidic environment is required for phosphorylation of DVL and LRP5/6 s_wca1_re51(MAP:survival): PMID:16547521 In the presence of WNT3a DVL-3 forms complex with KLHL12/CUL3/RBX1-complex s_wca1_re57(MAP:survival): PMID:19718039 PMID:21602792 In presence of WNT ligand s_wca1_re68(MAP:survival): PMID:20093472 PRR binds to subunits ATP6V0C and D those are subunits of the V-ATPase. References_end</body> </html> </notes> <label text="CK1ε*:E-Cadherin*:FZD*:GTP:Gαo*:Gβ*:Gγ*:LRP5_6*:PRR*:WNT*:p120*"/> <bbox w="282.0" h="232.0" x="13863.5" y="107.5"/> <glyph class="macromolecule" id="wca1_wca1_s183_wca1_wca1_sa146"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="53.0" h="123.0" x="14002.5" y="122.5"/> <glyph class="state variable" id="_9bda68ac-7438-451f-ab02-f0d59d797e6f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14050.5" y="117.5"/> </glyph> <glyph class="state variable" id="_cd70c4e7-8371-4930-ad2b-efe858bc2251"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="13988.345" y="117.5"/> </glyph> <glyph class="state variable" id="_6f51b870-bc98-4fd6-9730-e2c98a94459d"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="14040.5" y="118.160416"/> </glyph> <glyph class="state variable" id="_f912dcad-5629-4f35-8b3c-aa0db8d87b76"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="14038.569" y="240.5"/> </glyph> <glyph class="state variable" id="_3c1a3b88-1c4a-4c6a-b6c4-ad54fd9036b6"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="13987.659" y="240.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s184_wca1_wca1_sa147"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="14056.5" y="203.5"/> <glyph class="state variable" id="_aef3d78a-c115-4924-af41-57c069fce837"> <state value="" variable="S268"/> <bbox w="30.0" h="10.0" x="14041.992" y="198.5"/> </glyph> <glyph class="state variable" id="_69206721-bcf2-4ae7-b1a8-74a8aeced40a"> <state value="" variable="S269"/> <bbox w="30.0" h="10.0" x="14081.532" y="198.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s185_wca1_wca1_sa148"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="14054.5" y="243.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1376_wca1_wca1_sa149"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="13943.0" y="154.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s173_wca1_wca1_sa150"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="13922.0" y="174.5"/> <glyph class="state variable" id="_ca8313de-903b-4b20-a475-80b0b5c2a922"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="13904.5" y="194.46019"/> </glyph> <glyph class="state variable" id="_cbf506df-b93f-4b84-a115-573f95f21dad"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="13944.532" y="169.5"/> </glyph> <glyph class="state variable" id="_1831b787-d5ec-4c5c-865f-bd709a821691"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="13984.5" y="169.76846"/> </glyph> <glyph class="state variable" id="_cf246558-04e4-4a3f-adec-9eeab3d39051"> <state value="" variable="S1496"/> <bbox w="35.0" h="10.0" x="13983.882" y="219.5"/> </glyph> <glyph class="state variable" id="_b558f008-dc28-4822-af88-017666c12085"> <state value="" variable="T1530"/> <bbox w="35.0" h="10.0" x="13943.6045" y="219.5"/> </glyph> <glyph class="state variable" id="_4f9220cb-def7-48af-86ed-f096690572b2"> <state value="" variable="S1533"/> <bbox w="35.0" h="10.0" x="13904.74" y="219.5"/> </glyph> <glyph class="unit of information" id="_6e81de90-ae8a-44c1-9c1d-e41bc18223ac"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="13939.5" y="169.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1378_wca1_wca1_sa151"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="13922.0" y="218.5"/> <glyph class="unit of information" id="_df4cb7d2-1f40-406a-a4bd-4a9912084007"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="13939.5" y="213.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1379_wca1_wca1_sa169"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein) alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 (Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 guanine nucleotide binding protein (G protein) alpha activating activity polypeptide olfactory type HUGO:GNAL HGNC:4388 ENTREZ:2774 UNIPROT:P38405 GENECARDS:GNAL REACTOME:55364 ATLASONC:GC_GNAL WIKI:GNAL guanine nucleotide binding protein (G protein) alpha activating activity polypeptide O HUGO:GNAO1 HGNC:4389 ENTREZ:2775 UNIPROT:P09471 GENECARDS:GNAO1 REACTOME:55350 KEGG:2775 ATLASONC:GC_GNAO1 WIKI:GNAO1 guanine nucleotide binding protein (G protein) q polypeptide HUGO:GNAQ HGNC:4390 ENTREZ:2776 UNIPROT:P50148 GENECARDS:GNAQ REACTOME:55454 KEGG:2776 ATLASONC:GNAQID43280ch9q21 WIKI:GNAQ Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21640127 References_end</body> </html> </notes> <label text="Gαo*"/> <bbox w="40.0" h="20.0" x="13908.0" y="268.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1380_wca1_wca1_sa170"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="13949.5" y="268.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1381_wca1_wca1_sa171"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="13991.0" y="268.0"/> </glyph> <glyph class="simple chemical" id="wca1_wca1_s1382_wca1_wca1_sa173"> <label text="GTP"/> <bbox w="25.0" h="25.0" x="13916.0" y="290.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1371_wca1_wca1_sa649"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end</body> </html> </notes> <label text="PRR*"/> <bbox w="50.0" h="40.0" x="13866.5" y="200.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s211_wca1_wca1_csa28" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FZD*:GDP:G_alpha_o*:G_beta_*:G_gamma_* Identifiers_end References_begin: s_wca1_re25:(MAP:survival) PMID:21606194 PMID:19705439 References_end</body> </html> </notes> <label text="FZD*:GDP:Gαo*:Gβ*:Gγ*"/> <bbox w="161.0" h="113.0" x="13302.5" y="162.5"/> <glyph class="macromolecule" id="wca1_wca1_s172_wca1_wca1_sa138"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="13345.5" y="177.5"/> <glyph class="unit of information" id="_408bd171-c3d2-4128-bea6-ef6b1fca7c22"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="13363.0" y="172.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s489_wca1_wca1_sa166"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein) alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 (Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 guanine nucleotide binding protein (G protein) alpha activating activity polypeptide olfactory type HUGO:GNAL HGNC:4388 ENTREZ:2774 UNIPROT:P38405 GENECARDS:GNAL REACTOME:55364 ATLASONC:GC_GNAL WIKI:GNAL guanine nucleotide binding protein (G protein) alpha activating activity polypeptide O HUGO:GNAO1 HGNC:4389 ENTREZ:2775 UNIPROT:P09471 GENECARDS:GNAO1 REACTOME:55350 KEGG:2775 ATLASONC:GC_GNAO1 WIKI:GNAO1 guanine nucleotide binding protein (G protein) q polypeptide HUGO:GNAQ HGNC:4390 ENTREZ:2776 UNIPROT:P50148 GENECARDS:GNAQ REACTOME:55454 KEGG:2776 ATLASONC:GNAQID43280ch9q21 WIKI:GNAQ Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21640127 References_end</body> </html> </notes> <label text="Gαo*"/> <bbox w="40.0" h="20.0" x="13323.5" y="229.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s488_wca1_wca1_sa167"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="13365.0" y="229.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s487_wca1_wca1_sa168"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="13406.5" y="229.5"/> </glyph> <glyph class="simple chemical" id="wca1_wca1_s218_wca1_wca1_sa172"> <label text="GDP"/> <bbox w="25.0" h="25.0" x="13314.5" y="202.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s226_wca1_wca1_csa30" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:G_beta_*:G_gamma_* Identifiers_end</body> </html> </notes> <label text="Gβ*:Gγ*"/> <bbox w="104.0" h="44.0" x="13683.0" y="556.0"/> <glyph class="macromolecule" id="wca1_wca1_s209_wca1_wca1_sa164"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="13695.25" y="559.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s210_wca1_wca1_sa165"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="13734.0" y="559.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s232_wca1_wca1_csa33" compartmentRef="wca1_wca1_c4_wca1_wca1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:CK1_epsilon_*:CK1_gamma_*:DVL*:E-Cadherin*:FZD*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:_beta_-Arrestin2*:p120* Identifiers_end References_begin: s_wca1_re32:(MAP:survival) PMID:17569865 PMID:20229235 s_wca1_re33(MAP:survival): PMID:19561074 PMID:20460648 PMID:19581931 PMID:21304492 PMID:21498506 AMER1 recruits axin References_end</body> </html> </notes> <label text="AMER1*:CK1ε*:CK1γ*:DVL*:E-Cadherin*:FZD*:Gβ*:Gγ*:LRP5_6*:PRR*:WNT*:β-Arrestin2*:p120*"/> <bbox w="325.0" h="231.0" x="14669.5" y="106.5"/> <glyph class="macromolecule" id="wca1_wca1_s268_wca1_wca1_sa201"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="53.0" h="123.0" x="14816.5" y="121.5"/> <glyph class="state variable" id="_3215add0-13c6-42be-85e0-42fd519fc2da"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14864.5" y="116.5"/> </glyph> <glyph class="state variable" id="_74ae654f-8539-42ae-8faa-c3ba49dba5cd"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="14802.345" y="116.5"/> </glyph> <glyph class="state variable" id="_37c1581a-a806-498c-91cf-22fd70130188"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="14854.5" y="117.160416"/> </glyph> <glyph class="state variable" id="_29761102-5ca8-4d7d-ae4c-7004a75c70dc"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="14852.569" y="239.5"/> </glyph> <glyph class="state variable" id="_f26273ae-e6c3-4723-92e1-cbbdf35b0511"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="14801.659" y="239.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s269_wca1_wca1_sa202"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="14870.5" y="202.5"/> <glyph class="state variable" id="_bac1fe91-496f-405a-a251-44e7a0b3b5d6"> <state value="" variable="S268"/> <bbox w="30.0" h="10.0" x="14855.992" y="197.5"/> </glyph> <glyph class="state variable" id="_aa5cec0a-e664-477e-b26e-90b0ef45b61b"> <state value="" variable="S269"/> <bbox w="30.0" h="10.0" x="14895.532" y="197.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s270_wca1_wca1_sa203"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="14868.5" y="242.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s285_wca1_wca1_sa204"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="14736.0" y="173.5"/> <glyph class="state variable" id="_811dd517-c1c6-407e-ad5e-504f077c8368"> <state value="P" variable="T1479"/> <bbox w="40.0" h="10.0" x="14716.0" y="193.46019"/> </glyph> <glyph class="state variable" id="_eff1b790-cd25-4496-9eee-6c2b1446cc7e"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="14758.532" y="168.5"/> </glyph> <glyph class="state variable" id="_7b244931-2938-437a-883a-463dd39f713d"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="14798.5" y="168.76846"/> </glyph> <glyph class="state variable" id="_e500a9c1-8f63-4ed0-b4bd-77c7ef901a15"> <state value="" variable="S1496"/> <bbox w="35.0" h="10.0" x="14797.882" y="218.5"/> </glyph> <glyph class="state variable" id="_3be0cff5-22d6-4e8b-b629-75157d8c2828"> <state value="" variable="T1530"/> <bbox w="35.0" h="10.0" x="14757.6045" y="218.5"/> </glyph> <glyph class="state variable" id="_5bcce195-a8eb-47f1-910a-0b3d42ef2915"> <state value="" variable="S1533"/> <bbox w="35.0" h="10.0" x="14718.74" y="218.5"/> </glyph> <glyph class="unit of information" id="_bdffe062-8c60-41dd-afc6-19f74d8fd388"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14753.5" y="168.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s272_wca1_wca1_sa205"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="14736.0" y="217.5"/> <glyph class="unit of information" id="_c95bee9d-5c03-4e9b-a36b-93ab55690f72"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14753.5" y="212.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s274_wca1_wca1_sa207"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="14736.75" y="265.5"/> <glyph class="state variable" id="_ad1ace8e-86ef-4d9d-b885-5acab7ae6d8d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14809.25" y="260.5"/> </glyph> <glyph class="state variable" id="_356fdad4-b13d-468a-831d-9f46ad7d9044"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14731.75" y="260.5"/> </glyph> <glyph class="state variable" id="_5b291eb4-ba78-4208-a818-dd62bf75fa11"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="14801.132" y="300.5"/> </glyph> <glyph class="state variable" id="_97d6bbda-d539-45da-b92d-3b81663f4c11"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14731.75" y="260.5"/> </glyph> <glyph class="state variable" id="_da9ead4f-0066-4485-bedb-5dd81f7eb8dd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14811.75" y="260.5"/> </glyph> <glyph class="state variable" id="_84dddc06-5ce6-4cb7-9317-8a1a9af77349"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14811.384" y="260.5"/> </glyph> <glyph class="state variable" id="_eaaf89f7-c604-4ef0-b1af-ea13aa7390c3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14811.75" y="300.5"/> </glyph> <glyph class="state variable" id="_f9cda185-d97e-4d78-9ffb-a77ba255043a"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="14721.75" y="300.2223"/> </glyph> <glyph class="state variable" id="_154fbf41-f6ac-49ea-8dfe-0b4ad969d469"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14731.75" y="300.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s511_wca1_wca1_sa411"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1γ*"/> <bbox w="80.0" h="40.0" x="14871.5" y="161.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s862_wca1_wca1_sa546"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="14817.5" y="285.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s861_wca1_wca1_sa547"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="14857.5" y="285.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s890_wca1_wca1_sa556"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="14898.5" y="284.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s989_wca1_wca1_sa583"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="14899.0" y="119.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s273_wca1_wca1_sa608"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="14759.0" y="159.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1393_wca1_wca1_sa655"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end</body> </html> </notes> <label text="PRR*"/> <bbox w="50.0" h="40.0" x="14683.182" y="202.18182"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s299_wca1_wca1_csa35" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AXIN*:CK1_alpha_*:GSK3*:G_alpha_o*:_beta_-Arrestin2* Identifiers_end References_begin: s_wca1_re45:(MAP:survival) PMID:20460648 PMID:18077588 PMID:19705439 PMID:17426148 s_wca1_re33(MAP:survival): PMID:19561074 PMID:20460648 PMID:19581931 PMID:21304492 PMID:21498506 AMER1 recruits axin s_wca1_re37(MAP:survival): PMID:20229235 PMID:18077588 PMID:21304492 PMID:21498506 Phosphorylation of the repeat PPSP A allows recruitment of additional GSK/AXIN which phosphorylates LRP5/6 on other PPSP repeats resulting of sequestering of GSK3 and AXIN away from the destruction complex AMER1 recruits axin and GSk3 References_end</body> </html> </notes> <label text="AXIN*:CK1α*:GSK3*:Gαo*:β-Arrestin2*"/> <bbox w="192.0" h="121.0" x="13584.5" y="908.0"/> <glyph class="macromolecule" id="wca1_wca1_s657_wca1_wca1_sa177"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein) alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 (Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 guanine nucleotide binding protein (G protein) alpha activating activity polypeptide olfactory type HUGO:GNAL HGNC:4388 ENTREZ:2774 UNIPROT:P38405 GENECARDS:GNAL REACTOME:55364 ATLASONC:GC_GNAL WIKI:GNAL guanine nucleotide binding protein (G protein) alpha activating activity polypeptide O HUGO:GNAO1 HGNC:4389 ENTREZ:2775 UNIPROT:P09471 GENECARDS:GNAO1 REACTOME:55350 KEGG:2775 ATLASONC:GC_GNAO1 WIKI:GNAO1 guanine nucleotide binding protein (G protein) q polypeptide HUGO:GNAQ HGNC:4390 ENTREZ:2776 UNIPROT:P50148 GENECARDS:GNAQ REACTOME:55454 KEGG:2776 ATLASONC:GNAQID43280ch9q21 WIKI:GNAQ Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21640127 References_end</body> </html> </notes> <label text="Gαo*"/> <bbox w="40.0" h="20.0" x="13671.5" y="995.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s300_wca1_wca1_sa212"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="13595.25" y="915.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s301_wca1_wca1_sa213"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="13595.5" y="957.0"/> <glyph class="state variable" id="_66a1baab-fe3c-46b5-b53b-6edffe654d4c"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="13583.492" y="952.0"/> </glyph> <glyph class="state variable" id="_886365a8-c204-46df-ad6c-859e839df9d1"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="13623.032" y="952.0"/> </glyph> <glyph class="state variable" id="_b2925e6a-98c2-4514-b0b6-c0bfacaa6a22"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="13660.5" y="952.2148"/> </glyph> <glyph class="state variable" id="_b709eccd-fd2c-488b-87f7-b8a825375fbf"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="13659.882" y="992.0"/> </glyph> <glyph class="state variable" id="_94690927-63ea-4677-a58c-964b8dc3be3e"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="13620.404" y="992.0"/> </glyph> <glyph class="state variable" id="_5023bc98-d9d5-4b84-8c51-68ce750b438c"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="13580.5" y="991.7223"/> </glyph> <glyph class="state variable" id="_c65704f7-6027-4451-b8be-677751613d94"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="13622.904" y="992.0"/> </glyph> <glyph class="state variable" id="_e22184ae-17b6-4e00-95c0-c858b6980b29"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="13662.382" y="992.0"/> </glyph> <glyph class="state variable" id="_e208a067-62cd-40c8-ae4d-ce7acda047bf"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="13668.0" y="952.2148"/> </glyph> <glyph class="state variable" id="_3e6a839f-9698-4ef3-b4a8-ef5b146b062b"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13583.0" y="991.7223"/> </glyph> <glyph class="state variable" id="_f2b663c0-bcff-4642-8ecc-84c31950cbc7"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="13588.492" y="952.0"/> </glyph> <glyph class="state variable" id="_0ec1282c-e13c-43fe-a85e-e1cda86cb6e6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13590.5" y="952.0"/> </glyph> <glyph class="state variable" id="_d641a727-e12f-42c9-ad6e-c55e3b7cfb4f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13670.5" y="952.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s302_wca1_wca1_sa214"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="13684.5" y="956.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s937_wca1_wca1_sa573"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="13681.5" y="914.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s486_wca1_wca1_csa43" compartmentRef="wca1_wca1_c5_wca1_wca1_ca9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK1_epsilon_*:p120* Identifiers_end References_begin: s_wca1_re42:(MAP:survival) PMID:21606194 References_end</body> </html> </notes> <label text="CK1ε*:p120*"/> <bbox w="100.0" h="120.0" x="14774.0" y="1986.0"/> <glyph class="macromolecule" id="wca1_wca1_s485_wca1_wca1_sa358"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="14786.5" y="2041.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s484_wca1_wca1_sa384"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="14785.5" y="2000.0"/> <glyph class="state variable" id="_af07221e-4f8d-4d82-b3ad-8729bc6cbcca"> <state value="P" variable="S268"/> <bbox w="35.0" h="10.0" x="14768.492" y="1995.0"/> </glyph> <glyph class="state variable" id="_20625cb7-37bf-4e08-951c-830bc75b930c"> <state value="P" variable="S269"/> <bbox w="35.0" h="10.0" x="14808.032" y="1995.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s604_wca1_wca1_csa50" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC:AXIN* Identifiers_end References_begin: s_wca1_re49:(MAP:survival) PMID:19576224 References_end</body> </html> </notes> <label text="APC:AXIN*"/> <bbox w="110.0" h="131.0" x="13527.0" y="1595.0"/> <glyph class="macromolecule" id="wca1_wca1_s602_wca1_wca1_sa467"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="13541.0" y="1660.0"/> <glyph class="state variable" id="_dd40c87f-540a-4a07-95c1-b0ce965df186"> <state value="P" variable="S80"/> <bbox w="30.0" h="10.0" x="13526.492" y="1655.0"/> </glyph> <glyph class="state variable" id="_dfe954fc-f48b-40c9-8792-2e02609b92a2"> <state value="P" variable="S82"/> <bbox w="30.0" h="10.0" x="13566.032" y="1655.0"/> </glyph> <glyph class="state variable" id="_79618ed3-4335-40ff-9828-a943b64609a0"> <state value="P" variable="S222"/> <bbox w="35.0" h="10.0" x="13603.5" y="1655.2147"/> </glyph> <glyph class="state variable" id="_9c48adfc-adc6-495b-895b-d442d760cf16"> <state value="P" variable="S473"/> <bbox w="35.0" h="10.0" x="13602.882" y="1695.0"/> </glyph> <glyph class="state variable" id="_9adcc6b4-4596-4aa2-8e23-ea1cdc73a19b"> <state value="P" variable="S614"/> <bbox w="35.0" h="10.0" x="13563.404" y="1695.0"/> </glyph> <glyph class="state variable" id="_d97f5599-9c17-499c-8d60-5698676c9057"> <state value="P" variable="S621"/> <bbox w="35.0" h="10.0" x="13523.5" y="1694.7223"/> </glyph> <glyph class="state variable" id="_85bcf3e4-e522-42f5-894f-62cc79aa2ee8"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="13568.404" y="1695.0"/> </glyph> <glyph class="state variable" id="_0a93e189-2d63-4d40-8fcc-ae3a1de02143"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="13607.882" y="1695.0"/> </glyph> <glyph class="state variable" id="_a23cf20e-9b6c-4839-95ec-0cc42d4a154c"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="13613.5" y="1655.2147"/> </glyph> <glyph class="state variable" id="_2368abd6-3841-4ece-a2a7-b32fe4a030af"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13528.5" y="1694.7223"/> </glyph> <glyph class="state variable" id="_51fe974a-0ea6-4d6a-8530-6a6b28ce18d1"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="13533.992" y="1655.0"/> </glyph> <glyph class="state variable" id="_d21a4122-7569-4571-a1dd-e107a95ed454"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13536.0" y="1655.0"/> </glyph> <glyph class="state variable" id="_017a8960-fb4a-4c7f-ac14-ec31dcf7f5e6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13616.0" y="1655.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s653_wca1_wca1_sa468"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="13540.5" y="1612.0"/> <glyph class="state variable" id="_40c7be49-5613-4b20-b3b1-b854f87f1db3"> <state value="P" variable="S1505"/> <bbox w="40.0" h="10.0" x="13599.882" y="1647.0"/> </glyph> <glyph class="state variable" id="_36b24939-06a1-4a99-9a72-bbe9b4c99203"> <state value="Ub" variable="S1501"/> <bbox w="45.0" h="10.0" x="13518.492" y="1607.0"/> </glyph> <glyph class="state variable" id="_0c1e3b8c-321f-466f-900e-0952548bd89f"> <state value="P" variable="S1504"/> <bbox w="40.0" h="10.0" x="13600.5" y="1607.2147"/> </glyph> <glyph class="state variable" id="_f4b82da4-6b83-4a91-9778-059e4616c29b"> <state value="P" variable="S1507"/> <bbox w="40.0" h="10.0" x="13560.404" y="1647.0"/> </glyph> <glyph class="state variable" id="_9e134665-7356-4417-89ad-ec1d56672e7d"> <state value="P" variable="S1503"/> <bbox w="40.0" h="10.0" x="13560.532" y="1607.0"/> </glyph> <glyph class="state variable" id="_cf945951-4321-402a-8d48-0121b405bc7d"> <state value="Ub" variable="S1510"/> <bbox w="45.0" h="10.0" x="13518.0" y="1646.7223"/> </glyph> <glyph class="state variable" id="_76b054f5-e943-4199-9d92-edddacc061f5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13615.5" y="1607.0"/> </glyph> <glyph class="state variable" id="_ee6c37fd-b6d9-4a26-bb94-dd2fa7de4939"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="13603.0" y="1646.1306"/> </glyph> <glyph class="state variable" id="_0d9e11d3-ab96-46a5-bd01-4de511cfdb46"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="13523.0" y="1646.7223"/> </glyph> <glyph class="state variable" id="_7bb93502-340b-4fd7-91f8-87cf3e14ba61"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13528.492" y="1607.0"/> </glyph> <glyph class="state variable" id="_cb62a550-f79f-4341-a8d3-ab93fff5e845"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="13523.492" y="1607.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s656_wca1_wca1_csa34" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AXIN*:CK1_alpha_*:GSK3* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21606194 s_wca1_re34(MAP:survival): PMID:21498506 Membrane-bound AMER1 acts as scaffold and brings APC to the membrane s_wca1_re45:(MAP:survival) PMID:20460648 PMID:18077588 PMID:19705439 PMID:17426148 s_wca2_re65(MAP:survival): Ubiquitination increases binding of APC with AXIN. PMID:23277359 References_end</body> </html> </notes> <label text="AXIN*:CK1α*:GSK3*"/> <bbox w="196.0" h="118.0" x="13314.25" y="910.5"/> <glyph class="macromolecule" id="wca1_wca1_s287_wca1_wca1_sa209"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="13325.0" y="917.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s288_wca1_wca1_sa210"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="13325.25" y="959.5"/> <glyph class="state variable" id="_b4073676-54bf-402b-8875-c7c980175c67"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="13313.242" y="954.5"/> </glyph> <glyph class="state variable" id="_f1b0701e-e35c-458b-bae7-3825de4119b2"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="13352.782" y="954.5"/> </glyph> <glyph class="state variable" id="_2691d2d4-fd5f-45ab-8cbd-30238b2ff2f6"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="13390.25" y="954.7148"/> </glyph> <glyph class="state variable" id="_e47c176d-4654-4d59-88da-c7a2a2282fdf"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="13389.632" y="994.5"/> </glyph> <glyph class="state variable" id="_ef64965f-adcf-41d0-8a61-4ebcbd3460f6"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="13350.154" y="994.5"/> </glyph> <glyph class="state variable" id="_b3d809aa-fe4f-441d-9f1b-04850d631e52"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="13310.25" y="994.2223"/> </glyph> <glyph class="state variable" id="_f76e2668-3578-4a10-b2dc-f273a01f0cfa"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="13352.654" y="994.5"/> </glyph> <glyph class="state variable" id="_d15b14da-8f02-4f37-ac12-22cd1fd97d1b"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="13392.132" y="994.5"/> </glyph> <glyph class="state variable" id="_4a1a3444-f73c-4d8d-a575-6830f8cc1b9f"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="13397.75" y="954.7148"/> </glyph> <glyph class="state variable" id="_73ea9afe-a571-43d9-9f34-a89f01599f51"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13312.75" y="994.2223"/> </glyph> <glyph class="state variable" id="_a7f186de-ce9a-4b31-b9af-9b4ab37d09a9"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="13318.242" y="954.5"/> </glyph> <glyph class="state variable" id="_2e04f3d9-b476-476e-b04f-924e0fb9a65f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13320.25" y="954.5"/> </glyph> <glyph class="state variable" id="_0de6c799-2c60-4ed7-9767-a986f757f903"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13400.25" y="954.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s538_wca1_wca1_sa426"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="13406.5" y="916.5"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s673_wca1_wca1_csa45" compartmentRef="wca1_wca1_c5_wca1_wca1_ca9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AXIN*:CK1_alpha_*:GSK3*:G_alpha_o*:_beta_-Arrestin2* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21606194 s_wca1_re43(MAP:survival): PMID:21606194 PMID:21285348 DVL is again phosphorylated to form PS-DVL. This isoform of DVL leads to depolimerisation of DVL and even distribution in the cell. Which CK1 isoform catalyses this reaction is unknown References_end</body> </html> </notes> <label text="AXIN*:CK1α*:GSK3*:Gαo*:β-Arrestin2*"/> <bbox w="191.0" h="140.0" x="14595.0" y="2428.0"/> <glyph class="macromolecule" id="wca1_wca1_s677_wca1_wca1_sa393"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein) alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 (Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 guanine nucleotide binding protein (G protein) alpha activating activity polypeptide olfactory type HUGO:GNAL HGNC:4388 ENTREZ:2774 UNIPROT:P38405 GENECARDS:GNAL REACTOME:55364 ATLASONC:GC_GNAL WIKI:GNAL guanine nucleotide binding protein (G protein) alpha activating activity polypeptide O HUGO:GNAO1 HGNC:4389 ENTREZ:2775 UNIPROT:P09471 GENECARDS:GNAO1 REACTOME:55350 KEGG:2775 ATLASONC:GC_GNAO1 WIKI:GNAO1 guanine nucleotide binding protein (G protein) q polypeptide HUGO:GNAQ HGNC:4390 ENTREZ:2776 UNIPROT:P50148 GENECARDS:GNAQ REACTOME:55454 KEGG:2776 ATLASONC:GNAQID43280ch9q21 WIKI:GNAQ Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21640127 References_end</body> </html> </notes> <label text="Gαo*"/> <bbox w="40.0" h="20.0" x="14711.75" y="2428.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s674_wca1_wca1_sa394"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="14607.25" y="2454.0"/> <glyph class="state variable" id="_827b3e94-c703-4632-b9f9-adfd4db42dc6"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="14595.242" y="2449.0"/> </glyph> <glyph class="state variable" id="_1a8dac4c-f5e8-4f0d-bd86-40f40aeef764"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="14634.782" y="2449.0"/> </glyph> <glyph class="state variable" id="_8b4a7076-ec8b-4a19-81bb-04e6368f8cc3"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="14672.25" y="2449.2148"/> </glyph> <glyph class="state variable" id="_902ddc09-d72a-44c1-b2f4-e1337088b04b"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="14671.632" y="2489.0"/> </glyph> <glyph class="state variable" id="_dbee0d75-c133-4026-ba04-d370e7b9718a"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="14632.154" y="2489.0"/> </glyph> <glyph class="state variable" id="_3642c994-8c1b-4ded-9d8e-8b8a3d6f92b8"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="14592.25" y="2488.7224"/> </glyph> <glyph class="state variable" id="_3ab2475f-1e70-4480-a736-ebd223de7799"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="14634.654" y="2489.0"/> </glyph> <glyph class="state variable" id="_eb60127c-c586-4307-8b20-736ff0800e5a"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="14674.132" y="2489.0"/> </glyph> <glyph class="state variable" id="_005470c3-f610-4802-9c04-af6b7801b8e8"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14679.75" y="2449.2148"/> </glyph> <glyph class="state variable" id="_c4c8631f-07d5-4141-8b53-407d0eba8da1"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="14594.75" y="2488.7224"/> </glyph> <glyph class="state variable" id="_10ec1108-2a4f-48a9-b895-792e7c62e6b8"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14600.242" y="2449.0"/> </glyph> <glyph class="state variable" id="_4856029b-40b6-44de-8806-744c3338fcf5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14602.25" y="2449.0"/> </glyph> <glyph class="state variable" id="_6bb9146c-06ab-4fcf-8e70-705dd292fe2e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14682.25" y="2449.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s675_wca1_wca1_sa395"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="14694.25" y="2456.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s676_wca1_wca1_sa396"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="14606.75" y="2502.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s935_wca1_wca1_sa571"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="14691.5" y="2500.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s725_wca1_wca1_csa52" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CUL3:KLHL*:RBX1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:16547521 s_wca1_re51(MAP:survival): In the presence of WNT3a DVL-3 forms complex with KLHL12/CUL3/RBX1-complex References_end</body> </html> </notes> <label text="CUL3:KLHL*:RBX1"/> <bbox w="131.0" h="161.0" x="12733.25" y="744.0"/> <glyph class="macromolecule" id="wca1_wca1_s722_wca1_wca1_sa522"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: kelch-like 1 (Drosophila) HUGO:KLHL1 HGNC:6352 ENTREZ:57626 UNIPROT:Q9NR64 GENECARDS:KLHL1 KEGG:57626 ATLASONC:GC_KLHL1 WIKI:KLHL1 kelch-like 2 Mayven (Drosophila) HUGO:KLHL2 HGNC:6353 ENTREZ:11275 UNIPROT:O95198 GENECARDS:KLHL2 KEGG:11275 ATLASONC:GC_KLHL2 WIKI:KLHL2 kelch-like 3 (Drosophila) HUGO:KLHL3 HGNC:6354 ENTREZ:26249 UNIPROT:Q9UH77 GENECARDS:KLHL3 KEGG:26249 WIKI:KLHL3 kelch-like 4 (Drosophila) HUGO:KLHL4 HGNC:6355 ENTREZ:56062 UNIPROT:Q9C0H6 GENECARDS:KLHL4 KEGG:56062 WIKI:KLHL4 kelch-like 5 (Drosophila) HUGO:KLHL5 HGNC:6356 ENTREZ:51088 UNIPROT:Q96PQ7 GENECARDS:KLHL5 WIKI:KLHL5 kelch-like 6 (Drosophila) HUGO:KLHL6 HGNC:18653 ENTREZ:89857 UNIPROT:Q8WZ60 GENECARDS:KLHL6 KEGG:55975 WIKI:KLHL6 kelch-like 7 (Drosophila) HUGO:KLHL7 HGNC:15646 ENTREZ:55975 UNIPROT:Q8IXQ5 GENECARDS:KLHL7 KEGG:55975 ATLASONC:GC_KLHL7 WIKI:KLHL7 kelch-like 8 (Drosophila) HUGO:KLHL8 HGNC:18644 ENTREZ:57563 UNIPROT:Q9P2G9 GENECARDS:KLHL8 WIKI:KLHL8 kelch-like 9 (Drosophila) HUGO:KLHL9 HGNC:18732 ENTREZ:55958 UNIPROT:Q9P2J3 GENECARDS:KLHL9 REACTOME:67738 WIKI:KLHL9 kelch-like 10 (Drosophila) HUGO:KLHL10 HGNC:18829 ENTREZ:317719 UNIPROT:Q6JEL2 GENECARDS:KLHL10 KEGG:317719 WIKI:KLHL10 kelch-like 11 (Drosophila) HUGO:KLHL11 HGNC:19008 ENTREZ:55175 UNIPROT:Q9NVR0 GENECARDS:KLHL11 WIKI:KLHL11 kelch-like 12 (Drosophila) HUGO:KLHL12 HGNC:19360 ENTREZ:59349 UNIPROT:Q53G59 GENECARDS:KLHL12 KEGG:59349 WIKI:KLHL12 kelch-like 13 (Drosophila) HUGO:KLHL13 HGNC:22931 ENTREZ:90293 UNIPROT:Q9P2N7 GENECARDS:KLHL13 REACTOME:67732 KEGG:90293 WIKI:KLHL13 kelch-like 14 (Drosophila) HUGO:KLHL14 HGNC:29266 ENTREZ:57565 UNIPROT:Q9P2G3 GENECARDS:KLHL14 WIKI:KLHL14 kelch-like 15 (Drosophila) HUGO:KLHL15 HGNC:29347 ENTREZ:80311 UNIPROT:Q96M94 GENECARDS:KLHL15 WIKI:KLHL15 kelch-like 17 (Drosophila) HUGO:KLHL17 HGNC:24023 ENTREZ:339451 UNIPROT:Q6TDP4 GENECARDS:KLHL17 KEGG:339451 WIKI:KLHL17 kelch-like 18 (Drosophila) HUGO:KLHL18 HGNC:29120 ENTREZ:23276 UNIPROT:O94889 GENECARDS:KLHL18 WIKI:KLHL18 kelch-like 20 (Drosophila) HUGO:KLHL20 HGNC:25056 ENTREZ:27252 UNIPROT:Q9Y2M5 GENECARDS:KLHL20 REACTOME:58067 KEGG:27252 ATLASONC:GC_KLHL20 WIKI:KLHL20 kelch-like 21 (Drosophila) HUGO:KLHL21 HGNC:29041 ENTREZ:9903 UNIPROT:Q9UJP4 GENECARDS:KLHL21 REACTOME:67612 ATLASONC:GC_KLHL21 WIKI:KLHL21 kelch-like 22 (Drosophila) HUGO:KLHL22 HGNC:25888 ENTREZ:84861 UNIPROT:Q53GT1 GENECARDS:KLHL22 KEGG:84861 WIKI:KLHL22 kelch-like 23 (Drosophila) HUGO:KLHL23 HGNC:27506 ENTREZ:151230 UNIPROT:Q8NBE8 GENECARDS:KLHL23 KEGG:151230 WIKI:KLHL23 kelch-like 24 (Drosophila) HUGO:KLHL24 HGNC:25947 ENTREZ:54800 UNIPROT:Q6TFL4 GENECARDS:KLHL24 KEGG:54800 WIKI:KLHL24 kelch-like 25 (Drosophila) HUGO:KLHL25 HGNC:25732 ENTREZ:64410 UNIPROT:Q9H0H3 GENECARDS:KLHL25 KEGG:64410 WIKI:KLHL25 kelch-like 26 (Drosophila) HUGO:KLHL26 HGNC:25623 ENTREZ:55295 UNIPROT:Q53HC5 GENECARDS:KLHL26 WIKI:KLHL26 kelch-like 28 (Drosophila) HUGO:KLHL28 HGNC:19741 ENTREZ:54813 UNIPROT:Q9NXS3 GENECARDS:KLHL28 KEGG:54813 WIKI:KLHL28 kelch-like 29 (Drosophila) HUGO:KLHL29 HGNC:29404 ENTREZ:114818 UNIPROT:Q96CT2 GENECARDS:KLHL29 KEGG:114818 WIKI:KLHL29 kelch-like 30 (Drosophila) HUGO:KLHL30 HGNC:24770 ENTREZ:377007 UNIPROT:Q0D2K2 GENECARDS:KLHL30 WIKI:KLHL30 kelch-like 31 (Drosophila) HUGO:KLHL31 HGNC:21353 ENTREZ:401265 UNIPROT:Q9H511 GENECARDS:KLHL31 KEGG:401265 WIKI:KLHL31 kelch-like 32 (Drosophila) HUGO:KLHL32 HGNC:21221 ENTREZ:114792 UNIPROT:Q96NJ5 GENECARDS:KLHL32 KEGG:114792 WIKI:KLHL32 kelch-like 33 (Drosophila) HUGO:KLHL33 HGNC:31952 ENTREZ:123103 UNIPROT:A6NCF5 GENECARDS:KLHL33 WIKI:KLHL33 kelch-like 34 (Drosophila) HUGO:KLHL34 HGNC:26634 ENTREZ:257240 UNIPROT:Q8N239 GENECARDS:KLHL34 WIKI:KLHL34 kelch-like 35 (Drosophila) HUGO:KLHL35 HGNC:26597 ENTREZ:283212 UNIPROT:Q6PF15 GENECARDS:KLHL35 KEGG:8507 WIKI:KLHL35 kelch-like 36 (Drosophila) HUGO:KLHL36 HGNC:17844 ENTREZ:79786 UNIPROT:Q8N4N3 GENECARDS:KLHL36 KEGG:79786 WIKI:KLHL36 kelch-like 38 (Drosophila) HUGO:KLHL38 HGNC:34435 ENTREZ:340359 UNIPROT:Q2WGJ6 GENECARDS:KLHL38 KEGG:340359 WIKI:KLHL38 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:16547521 References_end</body> </html> </notes> <label text="KLHL*"/> <bbox w="80.0" h="40.0" x="12756.5" y="753.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s723_wca1_wca1_sa523"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Cullin 3 HUGO:CUL3 HGNC:2553 ENTREZ:8452 UNIPROT:Q13618 GENECARDS:CUL3 REACTOME:53166 KEGG:8452 ATLASONC:GC_CUL3 WIKI:CUL3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17312394 PMID:15688063 References_end Identifiers_begin: Cullin 3 HUGO:CUL3 HGNC:2553 ENTREZ:8452 UNIPROT:Q13618 GENECARDS:CUL3 REACTOME:53166 KEGG:8452 ATLASONC:GC_CUL3 WIKI:CUL3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17312394 PMID:15688063 References_end</body> </html> </notes> <label text="CUL3"/> <bbox w="80.0" h="40.0" x="12756.5" y="795.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s724_wca1_wca1_sa524"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> </notes> <label text="RBX1"/> <bbox w="80.0" h="40.0" x="12756.5" y="837.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s731_wca1_wca1_csa53" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CUL3:DVL*:KLHL*:RBX1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:16547521 s_wca1_re51(MAP:survival): In the presence of WNT3a DVL-3 forms complex with KLHL12/CUL3/RBX1-complex References_end</body> </html> </notes> <label text="CUL3:DVL*:KLHL*:RBX1"/> <bbox w="187.0" h="129.0" x="12705.5" y="988.5"/> <glyph class="macromolecule" id="wca1_wca1_s727_wca1_wca1_sa525"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: kelch-like 1 (Drosophila) HUGO:KLHL1 HGNC:6352 ENTREZ:57626 UNIPROT:Q9NR64 GENECARDS:KLHL1 KEGG:57626 ATLASONC:GC_KLHL1 WIKI:KLHL1 kelch-like 2 Mayven (Drosophila) HUGO:KLHL2 HGNC:6353 ENTREZ:11275 UNIPROT:O95198 GENECARDS:KLHL2 KEGG:11275 ATLASONC:GC_KLHL2 WIKI:KLHL2 kelch-like 3 (Drosophila) HUGO:KLHL3 HGNC:6354 ENTREZ:26249 UNIPROT:Q9UH77 GENECARDS:KLHL3 KEGG:26249 WIKI:KLHL3 kelch-like 4 (Drosophila) HUGO:KLHL4 HGNC:6355 ENTREZ:56062 UNIPROT:Q9C0H6 GENECARDS:KLHL4 KEGG:56062 WIKI:KLHL4 kelch-like 5 (Drosophila) HUGO:KLHL5 HGNC:6356 ENTREZ:51088 UNIPROT:Q96PQ7 GENECARDS:KLHL5 WIKI:KLHL5 kelch-like 6 (Drosophila) HUGO:KLHL6 HGNC:18653 ENTREZ:89857 UNIPROT:Q8WZ60 GENECARDS:KLHL6 KEGG:55975 WIKI:KLHL6 kelch-like 7 (Drosophila) HUGO:KLHL7 HGNC:15646 ENTREZ:55975 UNIPROT:Q8IXQ5 GENECARDS:KLHL7 KEGG:55975 ATLASONC:GC_KLHL7 WIKI:KLHL7 kelch-like 8 (Drosophila) HUGO:KLHL8 HGNC:18644 ENTREZ:57563 UNIPROT:Q9P2G9 GENECARDS:KLHL8 WIKI:KLHL8 kelch-like 9 (Drosophila) HUGO:KLHL9 HGNC:18732 ENTREZ:55958 UNIPROT:Q9P2J3 GENECARDS:KLHL9 REACTOME:67738 WIKI:KLHL9 kelch-like 10 (Drosophila) HUGO:KLHL10 HGNC:18829 ENTREZ:317719 UNIPROT:Q6JEL2 GENECARDS:KLHL10 KEGG:317719 WIKI:KLHL10 kelch-like 11 (Drosophila) HUGO:KLHL11 HGNC:19008 ENTREZ:55175 UNIPROT:Q9NVR0 GENECARDS:KLHL11 WIKI:KLHL11 kelch-like 12 (Drosophila) HUGO:KLHL12 HGNC:19360 ENTREZ:59349 UNIPROT:Q53G59 GENECARDS:KLHL12 KEGG:59349 WIKI:KLHL12 kelch-like 13 (Drosophila) HUGO:KLHL13 HGNC:22931 ENTREZ:90293 UNIPROT:Q9P2N7 GENECARDS:KLHL13 REACTOME:67732 KEGG:90293 WIKI:KLHL13 kelch-like 14 (Drosophila) HUGO:KLHL14 HGNC:29266 ENTREZ:57565 UNIPROT:Q9P2G3 GENECARDS:KLHL14 WIKI:KLHL14 kelch-like 15 (Drosophila) HUGO:KLHL15 HGNC:29347 ENTREZ:80311 UNIPROT:Q96M94 GENECARDS:KLHL15 WIKI:KLHL15 kelch-like 17 (Drosophila) HUGO:KLHL17 HGNC:24023 ENTREZ:339451 UNIPROT:Q6TDP4 GENECARDS:KLHL17 KEGG:339451 WIKI:KLHL17 kelch-like 18 (Drosophila) HUGO:KLHL18 HGNC:29120 ENTREZ:23276 UNIPROT:O94889 GENECARDS:KLHL18 WIKI:KLHL18 kelch-like 20 (Drosophila) HUGO:KLHL20 HGNC:25056 ENTREZ:27252 UNIPROT:Q9Y2M5 GENECARDS:KLHL20 REACTOME:58067 KEGG:27252 ATLASONC:GC_KLHL20 WIKI:KLHL20 kelch-like 21 (Drosophila) HUGO:KLHL21 HGNC:29041 ENTREZ:9903 UNIPROT:Q9UJP4 GENECARDS:KLHL21 REACTOME:67612 ATLASONC:GC_KLHL21 WIKI:KLHL21 kelch-like 22 (Drosophila) HUGO:KLHL22 HGNC:25888 ENTREZ:84861 UNIPROT:Q53GT1 GENECARDS:KLHL22 KEGG:84861 WIKI:KLHL22 kelch-like 23 (Drosophila) HUGO:KLHL23 HGNC:27506 ENTREZ:151230 UNIPROT:Q8NBE8 GENECARDS:KLHL23 KEGG:151230 WIKI:KLHL23 kelch-like 24 (Drosophila) HUGO:KLHL24 HGNC:25947 ENTREZ:54800 UNIPROT:Q6TFL4 GENECARDS:KLHL24 KEGG:54800 WIKI:KLHL24 kelch-like 25 (Drosophila) HUGO:KLHL25 HGNC:25732 ENTREZ:64410 UNIPROT:Q9H0H3 GENECARDS:KLHL25 KEGG:64410 WIKI:KLHL25 kelch-like 26 (Drosophila) HUGO:KLHL26 HGNC:25623 ENTREZ:55295 UNIPROT:Q53HC5 GENECARDS:KLHL26 WIKI:KLHL26 kelch-like 28 (Drosophila) HUGO:KLHL28 HGNC:19741 ENTREZ:54813 UNIPROT:Q9NXS3 GENECARDS:KLHL28 KEGG:54813 WIKI:KLHL28 kelch-like 29 (Drosophila) HUGO:KLHL29 HGNC:29404 ENTREZ:114818 UNIPROT:Q96CT2 GENECARDS:KLHL29 KEGG:114818 WIKI:KLHL29 kelch-like 30 (Drosophila) HUGO:KLHL30 HGNC:24770 ENTREZ:377007 UNIPROT:Q0D2K2 GENECARDS:KLHL30 WIKI:KLHL30 kelch-like 31 (Drosophila) HUGO:KLHL31 HGNC:21353 ENTREZ:401265 UNIPROT:Q9H511 GENECARDS:KLHL31 KEGG:401265 WIKI:KLHL31 kelch-like 32 (Drosophila) HUGO:KLHL32 HGNC:21221 ENTREZ:114792 UNIPROT:Q96NJ5 GENECARDS:KLHL32 KEGG:114792 WIKI:KLHL32 kelch-like 33 (Drosophila) HUGO:KLHL33 HGNC:31952 ENTREZ:123103 UNIPROT:A6NCF5 GENECARDS:KLHL33 WIKI:KLHL33 kelch-like 34 (Drosophila) HUGO:KLHL34 HGNC:26634 ENTREZ:257240 UNIPROT:Q8N239 GENECARDS:KLHL34 WIKI:KLHL34 kelch-like 35 (Drosophila) HUGO:KLHL35 HGNC:26597 ENTREZ:283212 UNIPROT:Q6PF15 GENECARDS:KLHL35 KEGG:8507 WIKI:KLHL35 kelch-like 36 (Drosophila) HUGO:KLHL36 HGNC:17844 ENTREZ:79786 UNIPROT:Q8N4N3 GENECARDS:KLHL36 KEGG:79786 WIKI:KLHL36 kelch-like 38 (Drosophila) HUGO:KLHL38 HGNC:34435 ENTREZ:340359 UNIPROT:Q2WGJ6 GENECARDS:KLHL38 KEGG:340359 WIKI:KLHL38 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:16547521 References_end</body> </html> </notes> <label text="KLHL*"/> <bbox w="80.0" h="40.0" x="12714.75" y="1004.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s728_wca1_wca1_sa526"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Cullin 3 HUGO:CUL3 HGNC:2553 ENTREZ:8452 UNIPROT:Q13618 GENECARDS:CUL3 REACTOME:53166 KEGG:8452 ATLASONC:GC_CUL3 WIKI:CUL3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17312394 PMID:15688063 References_end Identifiers_begin: Cullin 3 HUGO:CUL3 HGNC:2553 ENTREZ:8452 UNIPROT:Q13618 GENECARDS:CUL3 REACTOME:53166 KEGG:8452 ATLASONC:GC_CUL3 WIKI:CUL3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17312394 PMID:15688063 References_end</body> </html> </notes> <label text="CUL3"/> <bbox w="80.0" h="40.0" x="12714.75" y="1046.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s729_wca1_wca1_sa527"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> </notes> <label text="RBX1"/> <bbox w="80.0" h="40.0" x="12797.75" y="1045.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s730_wca1_wca1_sa529"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="12796.75" y="1004.0"/> <glyph class="state variable" id="_eac361bb-ad3a-4805-98f1-2275db20aeaf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12871.75" y="999.0"/> </glyph> <glyph class="state variable" id="_442b2980-d95d-4804-bada-961553d55aea"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12791.75" y="999.0"/> </glyph> <glyph class="state variable" id="_59a5c4e4-d5bb-4c24-b0cd-bec3d99bd8f3"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="12861.132" y="1039.0"/> </glyph> <glyph class="state variable" id="_9dff93f5-b702-4e09-8d0c-ee88f6692231"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12791.75" y="999.0"/> </glyph> <glyph class="state variable" id="_95d5953c-09c2-4db9-a42b-51fa86430a3f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12871.75" y="999.0"/> </glyph> <glyph class="state variable" id="_cb059c75-2176-4bca-890e-51eae973bcba"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12871.384" y="999.0"/> </glyph> <glyph class="state variable" id="_35056923-7916-4434-a480-df9c21ffcae2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12871.75" y="1039.0"/> </glyph> <glyph class="state variable" id="_d4cf6e3d-9e09-4665-8154-b203327ae574"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="12781.75" y="1038.7223"/> </glyph> <glyph class="state variable" id="_02882048-3a76-4e3c-90ee-d3ba4985b42c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12791.75" y="1039.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s752_wca1_wca1_csa54" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DVL*:Iversin* Identifiers_end References_begin: s_wca1_re53:(MAP:survival) PMID:15852005 References_end</body> </html> </notes> <label text="DVL*:Iversin*"/> <bbox w="100.0" h="120.0" x="12710.0" y="1257.0"/> <glyph class="macromolecule" id="wca1_wca1_s736_wca1_wca1_sa532"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: inversin HUGO:INVS HGNC:17870 ENTREZ:27130 UNIPROT:Q9Y283 GENECARDS:INVS KEGG:27130 WIKI:INVS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15852005 References_end</body> </html> </notes> <label text="Iversin*"/> <bbox w="80.0" h="40.0" x="12719.0" y="1270.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s735_wca1_wca1_sa533"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="12719.0" y="1313.0"/> <glyph class="state variable" id="_ee9083d6-7dcc-4838-908b-cfae455ca63a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12794.0" y="1308.0"/> </glyph> <glyph class="state variable" id="_580d48c2-b82d-4c92-b6ae-75b1ecae3c44"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12714.0" y="1308.0"/> </glyph> <glyph class="state variable" id="_45d4c86f-b8e5-4069-8528-036835a394cc"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="12783.382" y="1348.0"/> </glyph> <glyph class="state variable" id="_6c45cc4e-64b5-49c7-8670-10f4a3f770cd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12714.0" y="1308.0"/> </glyph> <glyph class="state variable" id="_b3e55115-390c-45f5-9b94-2d7d92f7b9aa"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12794.0" y="1308.0"/> </glyph> <glyph class="state variable" id="_5d2546a3-26b5-4038-9dae-1f3e992985ee"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12793.634" y="1308.0"/> </glyph> <glyph class="state variable" id="_acfb8bfb-969e-4684-a050-3a9ceea01aa2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12794.0" y="1348.0"/> </glyph> <glyph class="state variable" id="_b0ccfd70-153e-4a8f-a1ad-c60fd5f478b8"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="12704.0" y="1347.7223"/> </glyph> <glyph class="state variable" id="_1f37def3-443f-40ff-b506-13ce939f82f5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12714.0" y="1348.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s753_wca1_wca1_csa55" compartmentRef="wca1_wca1_c2_wca1_wca1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DVL*:Iversin* Identifiers_end References_begin: s_wca1_re55:(MAP:survival) PMID:15852005 References_end</body> </html> </notes> <label text="DVL*:Iversin*"/> <bbox w="100.0" h="120.0" x="13041.5" y="103.0"/> <glyph class="macromolecule" id="wca1_wca1_s754_wca1_wca1_sa534"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: inversin HUGO:INVS HGNC:17870 ENTREZ:27130 UNIPROT:Q9Y283 GENECARDS:INVS KEGG:27130 WIKI:INVS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15852005 References_end</body> </html> </notes> <label text="Iversin*"/> <bbox w="80.0" h="40.0" x="13050.5" y="116.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s755_wca1_wca1_sa535"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="13050.5" y="159.0"/> <glyph class="state variable" id="_57dce877-41f0-42f9-b097-d695d6824459"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13125.5" y="154.0"/> </glyph> <glyph class="state variable" id="_d3bcb679-4d55-45af-b4e2-bdbe38acfc3e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13045.5" y="154.0"/> </glyph> <glyph class="state variable" id="_fa323413-ee1c-4287-909f-0e592202358a"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="13114.882" y="194.0"/> </glyph> <glyph class="state variable" id="_aba12441-9bae-4230-b35e-7528e28e4d9d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13045.5" y="154.0"/> </glyph> <glyph class="state variable" id="_9c6b9ff4-e894-43de-9e95-174058160c3f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13125.5" y="154.0"/> </glyph> <glyph class="state variable" id="_e984ca51-b697-4309-bbd6-0ede0016cf55"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13125.134" y="154.0"/> </glyph> <glyph class="state variable" id="_8bbea034-3d3f-45ea-bc55-32b834bff0b9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13125.5" y="194.0"/> </glyph> <glyph class="state variable" id="_b531fb69-6983-4c6c-be83-490e15c93b39"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="13035.5" y="193.7223"/> </glyph> <glyph class="state variable" id="_8c863e3c-c6bb-413c-9a08-c02dfb0d8f55"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13045.5" y="194.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s758_wca1_wca1_csa56" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:JBN*:_beta_-Catenin* Identifiers_end References_begin: s_wca1_re57(MAP:survival): PMID:19718039 PMID:21602792 In presence of WNT ligand References_end</body> </html> </notes> <label text="JBN*:β-Catenin*"/> <bbox w="100.0" h="120.0" x="13149.0" y="978.0"/> <glyph class="macromolecule" id="wca1_wca1_s760_wca1_wca1_sa538"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="13160.25" y="993.0"/> <glyph class="state variable" id="_bac65a72-38c7-4999-abf3-6d96eb53b43c"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="13187.654" y="1028.0"/> </glyph> <glyph class="state variable" id="_9fcdfd78-d6a9-41a6-b562-31c4bf6a3610"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="13227.132" y="1028.0"/> </glyph> <glyph class="state variable" id="_b9ec185f-f4e5-44ab-af48-ee1125366627"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="13227.75" y="988.2148"/> </glyph> <glyph class="state variable" id="_8963413d-b886-4d34-aab3-2dee986f4c97"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="13187.782" y="988.0"/> </glyph> <glyph class="state variable" id="_e7d1249f-0350-4aef-8284-3af93ecf4ef2"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="13148.242" y="988.0"/> </glyph> <glyph class="state variable" id="_22fa4aa7-38c0-4fe1-9a66-910eee3c7054"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="13147.75" y="1027.7223"/> </glyph> <glyph class="state variable" id="_f160c32a-96ac-4af2-bd7b-a4090eeb94dc"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="13225.25" y="988.2148"/> </glyph> <glyph class="state variable" id="_a8b2a3d3-54b3-4772-a90a-f6c979c19041"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="13225.25" y="988.2148"/> </glyph> <glyph class="state variable" id="_c4ab8379-3531-40ae-9d0b-195e41c56630"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13155.25" y="1008.0"/> </glyph> <glyph class="state variable" id="_f9e3f7e0-04b2-4ba8-8fde-666c5e3b3f12"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="13145.742" y="988.0"/> </glyph> <glyph class="state variable" id="_cca21935-68b6-404a-a7ed-a265f8760cc9"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="13225.25" y="988.2148"/> </glyph> <glyph class="state variable" id="_f37bc299-3f49-4247-ac13-ee7fc9357734"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13155.25" y="999.7157"/> </glyph> <glyph class="state variable" id="_61311f79-5037-419c-8c08-914892d5e244"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="13225.25" y="988.2148"/> </glyph> <glyph class="state variable" id="_cdab8ca2-e322-4dc3-a74d-cae4103a1489"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13155.25" y="1008.0"/> </glyph> <glyph class="state variable" id="_64e16404-36bf-4997-b438-f76e2a317cf3"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="13224.632" y="1028.0"/> </glyph> <glyph class="state variable" id="_b6032948-c258-46ad-b1e9-d65d30a640de"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="13225.25" y="988.2148"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s759_wca1_wca1_sa539"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Abelson helper integration site 1 HUGO:AHI1 HGNC:21575 ENTREZ:54806 UNIPROT:Q8N157 GENECARDS:AHI1 KEGG:54806 ATLASONC:GC_AHI1 WIKI:AHI1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19718039 PMID:21602792 References_end</body> </html> </notes> <label text="JBN*"/> <bbox w="80.0" h="40.0" x="13160.0" y="1036.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s761_wca1_wca1_csa57" compartmentRef="wca1_wca1_c2_wca1_wca1_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:JBN*:_beta_-Catenin* Identifiers_end References_begin: s_wca1_re57(MAP:survival): PMID:19718039 PMID:21602792 In presence of WNT ligand References_end</body> </html> </notes> <label text="JBN*:β-Catenin*"/> <bbox w="100.0" h="120.0" x="13173.5" y="104.0"/> <glyph class="macromolecule" id="wca1_wca1_s762_wca1_wca1_sa540"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="13186.75" y="119.0"/> <glyph class="state variable" id="_244b6e9d-cac4-4b2f-9c6a-2e5cf4384122"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="13214.154" y="154.0"/> </glyph> <glyph class="state variable" id="_852b7abc-9d83-4ec9-b9bb-732c009f3778"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="13253.632" y="154.0"/> </glyph> <glyph class="state variable" id="_80b8abac-cf73-40e9-97f3-5dead86c6d3c"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="13254.25" y="114.21477"/> </glyph> <glyph class="state variable" id="_a4fd80c5-694b-4bec-b812-234f6266997f"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="13214.282" y="114.0"/> </glyph> <glyph class="state variable" id="_1564801b-cd5a-4e40-9a68-a204fb8207ac"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="13174.742" y="114.0"/> </glyph> <glyph class="state variable" id="_0377c256-7d08-4e3d-8c96-f7c98e109534"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="13174.25" y="153.7223"/> </glyph> <glyph class="state variable" id="_c91f639d-8076-45b4-b3fd-c97c7b9d0c08"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="13251.75" y="114.21477"/> </glyph> <glyph class="state variable" id="_9629931c-b9a3-44bb-b0ad-2463f3d7f949"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="13251.75" y="114.21477"/> </glyph> <glyph class="state variable" id="_d66671a8-2726-4b82-a357-c11f6f8024d2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13181.75" y="134.0"/> </glyph> <glyph class="state variable" id="_cf5fe0eb-9101-4e39-a29d-056c786f88b5"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="13172.242" y="114.0"/> </glyph> <glyph class="state variable" id="_3e283069-ee40-405f-82c0-cef519977de0"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="13251.75" y="114.21477"/> </glyph> <glyph class="state variable" id="_8873b738-3e5d-40ab-a755-ddd636350e98"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13181.75" y="125.71573"/> </glyph> <glyph class="state variable" id="_d6598a46-fcc6-415d-bd3b-4049bdef68d8"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="13251.75" y="114.21477"/> </glyph> <glyph class="state variable" id="_a5524810-9d1b-4076-8729-5605ea26c70c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13181.75" y="134.0"/> </glyph> <glyph class="state variable" id="_a947236e-5dbd-4415-be53-6b1d219675bc"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="13251.132" y="154.0"/> </glyph> <glyph class="state variable" id="_cb478e98-fa93-4e07-9342-ed1aaa173c6e"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="13251.75" y="114.21477"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s763_wca1_wca1_sa541"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Abelson helper integration site 1 HUGO:AHI1 HGNC:21575 ENTREZ:54806 UNIPROT:Q8N157 GENECARDS:AHI1 KEGG:54806 ATLASONC:GC_AHI1 WIKI:AHI1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19718039 PMID:21602792 References_end</body> </html> </notes> <label text="JBN*"/> <bbox w="80.0" h="40.0" x="13184.5" y="162.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s764_wca1_wca1_csa58" compartmentRef="wca1_wca1_c3_wca1_wca1_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:JBN*:_beta_-Catenin* Identifiers_end References_begin: s_wca1_re58(MAP:survival): PMID:21602792 In presence of WNT ligand References_end</body> </html> </notes> <label text="JBN*:β-Catenin*"/> <bbox w="100.0" h="120.0" x="12967.0" y="1182.0"/> <glyph class="macromolecule" id="wca1_wca1_s765_wca1_wca1_sa542"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="12978.25" y="1197.0"/> <glyph class="state variable" id="_f4534e43-012c-4c6e-ae1f-21a0ec8dfef9"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="13005.654" y="1232.0"/> </glyph> <glyph class="state variable" id="_3af064cc-9462-45da-a6ae-bec98d0493ef"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="13045.132" y="1232.0"/> </glyph> <glyph class="state variable" id="_7da4b383-6790-40da-bd0a-70156c34d5bf"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="13045.75" y="1192.2147"/> </glyph> <glyph class="state variable" id="_f3fcd26d-7a72-45c8-8e6b-e842286036df"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="13005.782" y="1192.0"/> </glyph> <glyph class="state variable" id="_052d6244-a4cb-4182-ab1e-956d75a2ca52"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="12966.242" y="1192.0"/> </glyph> <glyph class="state variable" id="_8741c64a-e039-4ea7-b762-1a612ba69c0e"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="12965.75" y="1231.7223"/> </glyph> <glyph class="state variable" id="_82422b5e-93dd-458c-975e-4789dfc9567b"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="13043.25" y="1192.2147"/> </glyph> <glyph class="state variable" id="_69401498-ed5e-422b-b3cb-524ed18d2d63"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="13043.25" y="1192.2147"/> </glyph> <glyph class="state variable" id="_ca1968aa-02d4-4479-ab2f-c357c005b2e1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12973.25" y="1212.0"/> </glyph> <glyph class="state variable" id="_3c03ac44-9209-4fbf-8600-cfeb0327bdc2"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="12963.742" y="1192.0"/> </glyph> <glyph class="state variable" id="_0581911d-967d-419c-a2c5-76a53e4058c6"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="13043.25" y="1192.2147"/> </glyph> <glyph class="state variable" id="_90339ff4-c9c1-4886-bd85-4d2878244d99"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12973.25" y="1203.7157"/> </glyph> <glyph class="state variable" id="_f322ac2d-3594-4e1b-a1ac-f68b0237cfae"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="13043.25" y="1192.2147"/> </glyph> <glyph class="state variable" id="_76c6f496-bc20-4883-ad49-0bb019a6ec35"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12973.25" y="1212.0"/> </glyph> <glyph class="state variable" id="_41ab54a5-c8a4-4146-9a1a-62a0d546016e"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="13042.632" y="1232.0"/> </glyph> <glyph class="state variable" id="_f7e5f75d-92c7-4b45-961b-ebf38ef34cf1"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="13043.25" y="1192.2147"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s766_wca1_wca1_sa543"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Abelson helper integration site 1 HUGO:AHI1 HGNC:21575 ENTREZ:54806 UNIPROT:Q8N157 GENECARDS:AHI1 KEGG:54806 ATLASONC:GC_AHI1 WIKI:AHI1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19718039 PMID:21602792 References_end</body> </html> </notes> <label text="JBN*"/> <bbox w="80.0" h="40.0" x="12978.0" y="1240.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s865_wca1_wca1_csa59" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK2_alpha_:CK2_alpha_*:CK2_beta_* Identifiers_end References_begin: s_wca3_re77(MAP:survival): The C-terminus of APC inhibits activity of the CK2 enzyme PMID:11972058 s_wca3_re96(MAP:survival): Allosteric effect PMID:10747897 s_wca1_re26(MAP:survival): PMID:16707567 PMID:21285348 DVL is primed by CK2 and/or MARK2 s_wca2_re53:(MAP:survival) PMID:10671551 PMID:10837139 s_wca3_re78(MAP:survival): Site is adjacent to the NLS2 in APC PMID:11689703 s_wnc1_re1(MAP:survival): PMID:21506126 PAR1 can induce AKT phosphorylation; exact mechanism unknown also wich residues are unknown PMID:17374729 References_end</body> </html> </notes> <label text="CK2α:CK2α*:CK2β*"/> <bbox w="102.0" h="157.0" x="13333.0" y="655.0"/> <glyph class="macromolecule" id="wca1_wca1_s863_wca1_wca1_sa550"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 alpha 1 polypeptide HUGO:CSNK2A1 HGNC:2457 ENTREZ:1457 UNIPROT:P68400 GENECARDS:CSNK2A1 REACTOME:201673 KEGG:1457 ATLASONC:GC_CSNK2A1 WIKI:CSNK2A1 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 alpha 1 polypeptide HUGO:CSNK2A1 HGNC:2457 ENTREZ:1457 UNIPROT:P68400 GENECARDS:CSNK2A1 REACTOME:201673 KEGG:1457 ATLASONC:GC_CSNK2A1 WIKI:CSNK2A1 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2α*"/> <bbox w="80.0" h="40.0" x="13343.0" y="666.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s864_wca1_wca1_sa551"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2β*"/> <bbox w="80.0" h="40.0" x="13343.0" y="750.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1297_wca1_wca1_sa627"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 alpha prime polypeptide HUGO:CSNK2A2 HGNC:2459 ENTREZ:1459 UNIPROT:P19784 GENECARDS:CSNK2A2 REACTOME:57879 KEGG:1459 ATLASONC:GC_CSNK2A2 WIKI:CSNK2A2 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 alpha prime polypeptide HUGO:CSNK2A2 HGNC:2459 ENTREZ:1459 UNIPROT:P19784 GENECARDS:CSNK2A2 REACTOME:57879 KEGG:1459 ATLASONC:GC_CSNK2A2 WIKI:CSNK2A2 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2α'*"/> <bbox w="80.0" h="40.0" x="13343.0" y="709.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s889_wca1_wca1_csa29" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DVL*:G_beta_*:G_gamma_*:_beta_-Arrestin2* Identifiers_end References_begin: s_wca1_re29(MAP:survival): PMID:19705439 PMID:17426148 Beta-ARRESTIN binds to phosphorylated DVL s_wca1_re28(MAP:survival): PMID:20006983 PMID:16965538 PMID:210606194 PMID:20093472 PMID:21796133 Phosphorylation of DVL by CK1 epsilon. Activation of CK1 epsilon by unknown factor An acidic environment is required for phosphorylation of DVL and LRP5/6 References_end</body> </html> </notes> <label text="DVL*:Gβ*:Gγ*:β-Arrestin2*"/> <bbox w="107.0" h="150.0" x="13581.0" y="649.0"/> <glyph class="macromolecule" id="wca1_wca1_s883_wca1_wca1_sa176"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="13591.75" y="661.0"/> <glyph class="state variable" id="_a4d42633-0dd5-406a-b6d3-cad1f48c0308"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="13664.25" y="656.0"/> </glyph> <glyph class="state variable" id="_7e5c4c00-b685-4fd6-a9e8-612c3eeb2ec1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13586.75" y="656.0"/> </glyph> <glyph class="state variable" id="_263a8ecc-532e-4381-ab79-8d84cdf75948"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="13656.132" y="696.0"/> </glyph> <glyph class="state variable" id="_19e632f7-8eb9-4f97-8210-ffaaecff4151"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13586.75" y="656.0"/> </glyph> <glyph class="state variable" id="_d2ec499c-5d38-48d6-8e87-e987950038ad"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13666.75" y="656.0"/> </glyph> <glyph class="state variable" id="_f931f6fc-4d47-4a74-8837-4f882060d591"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13666.384" y="656.0"/> </glyph> <glyph class="state variable" id="_8e077648-f448-424a-b9a5-ecf29d433e01"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13666.75" y="696.0"/> </glyph> <glyph class="state variable" id="_5167c370-96c9-497d-844c-5ed47cb0625d"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="13576.75" y="695.7223"/> </glyph> <glyph class="state variable" id="_328b7e0d-9025-46ec-ace6-340ad02c413a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13586.75" y="696.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s303_wca1_wca1_sa215"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="13628.5" y="712.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s304_wca1_wca1_sa216"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="13588.5" y="712.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s887_wca1_wca1_sa554"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="13591.5" y="734.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s973_wca1_wca1_csa60" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:PtdIns Identifiers_end References_begin: s_wca1_re59:(MAP:survival) PMID:21304492 s_wca1_re76(MAP:survival): PMID:21498506 Cell contacts has positive influence on the function of membrane bound AMER1 s_wca1_re33(MAP:survival): PMID:19561074 PMID:20460648 PMID:19581931 PMID:21304492 PMID:21498506 AMER1 recruits axin s_wca1_re74:(MAP:survival) PMID:21498506 PMID:17925382 References_end</body> </html> </notes> <label text="AMER1*:PtdIns"/> <bbox w="97.0" h="92.0" x="15018.0" y="774.0"/> <glyph class="macromolecule" id="wca1_wca1_s976_wca1_wca1_sa575"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="15026.0" y="804.0"/> </glyph> <glyph class="simple chemical" id="wca1_wca1_s1655_wca1_wca1_sa576"> <label text="PtdIns(4,5)-P2"/> <bbox w="70.0" h="25.0" x="15034.0" y="775.5"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s988_wca1_wca1_csa62" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:CK1_gamma_*:PtdIns Identifiers_end References_begin: s_wca1_re60:(MAP:survival) PMID:21304492 s_wca1_re28(MAP:survival): PMID:20006983 PMID:16965538 PMID:210606194 PMID:20093472 PMID:21796133 Phosphorylation of DVL by CK1 epsilon. Activation of CK1 epsilon by unknown factor An acidic environment is required for phosphorylation of DVL and LRP5/6 s_wca1_re33(MAP:survival): PMID:19561074 PMID:20460648 PMID:19581931 PMID:21304492 PMID:21498506 AMER1 recruits axin s_wca1_re37(MAP:survival): PMID:20229235 PMID:18077588 PMID:21304492 PMID:21498506 Phosphorylation of the repeat PPSP A allows recruitment of additional GSK/AXIN which phosphorylates LRP5/6 on other PPSP repeats resulting of sequestering of GSK3 and AXIN away from the destruction complex AMER1 recruits axin and GSk3 References_end</body> </html> </notes> <label text="AMER1*:CK1γ*:PtdIns"/> <bbox w="80.0" h="155.0" x="15031.0" y="921.5"/> <glyph class="macromolecule" id="wca1_wca1_s984_wca1_wca1_sa577"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1γ*"/> <bbox w="80.0" h="40.0" x="15031.0" y="996.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s986_wca1_wca1_sa580"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="15031.0" y="951.5"/> </glyph> <glyph class="simple chemical" id="wca1_wca1_s987_wca1_wca1_sa581"> <label text="PtdIns(4,5)-P2"/> <bbox w="70.0" h="25.0" x="15036.0" y="925.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1187_wca1_wca1_csa63" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GTP:G_alpha_o* Identifiers_end References_begin: s_wca1_re28(MAP:survival): PMID:20006983 PMID:16965538 PMID:210606194 PMID:20093472 PMID:21796133 Phosphorylation of DVL by CK1 epsilon. Activation of CK1 epsilon by unknown factor An acidic environment is required for phosphorylation of DVL and LRP5/6 s_wca1_re45:(MAP:survival) PMID:20460648 PMID:18077588 PMID:19705439 PMID:17426148 s_wca1_re67:(MAP:survival) PMID:20562099 References_end</body> </html> </notes> <label text="GTP:Gαo*"/> <bbox w="70.0" h="80.0" x="13710.0" y="662.0"/> <glyph class="macromolecule" id="wca1_wca1_s208_wca1_wca1_sa163"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein) alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 (Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 guanine nucleotide binding protein (G protein) alpha activating activity polypeptide olfactory type HUGO:GNAL HGNC:4388 ENTREZ:2774 UNIPROT:P38405 GENECARDS:GNAL REACTOME:55364 ATLASONC:GC_GNAL WIKI:GNAL guanine nucleotide binding protein (G protein) alpha activating activity polypeptide O HUGO:GNAO1 HGNC:4389 ENTREZ:2775 UNIPROT:P09471 GENECARDS:GNAO1 REACTOME:55350 KEGG:2775 ATLASONC:GC_GNAO1 WIKI:GNAO1 guanine nucleotide binding protein (G protein) q polypeptide HUGO:GNAQ HGNC:4390 ENTREZ:2776 UNIPROT:P50148 GENECARDS:GNAQ REACTOME:55454 KEGG:2776 ATLASONC:GNAQID43280ch9q21 WIKI:GNAQ Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21640127 References_end</body> </html> </notes> <label text="Gαo*"/> <bbox w="40.0" h="20.0" x="13722.0" y="668.0"/> </glyph> <glyph class="simple chemical" id="wca1_wca1_s1186_wca1_wca1_sa622"> <label text="GTP"/> <bbox w="25.0" h="25.0" x="13727.5" y="689.5"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1188_wca1_wca1_csa64" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GDP:G_alpha_o* Identifiers_end References_begin: s_wca1_re67:(MAP:survival) PMID:20562099 References_end</body> </html> </notes> <label text="GDP:Gαo*"/> <bbox w="70.0" h="80.0" x="13696.0" y="821.0"/> <glyph class="macromolecule" id="wca1_wca1_s1390_wca1_wca1_sa623"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein) alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 (Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 guanine nucleotide binding protein (G protein) alpha activating activity polypeptide olfactory type HUGO:GNAL HGNC:4388 ENTREZ:2774 UNIPROT:P38405 GENECARDS:GNAL REACTOME:55364 ATLASONC:GC_GNAL WIKI:GNAL guanine nucleotide binding protein (G protein) alpha activating activity polypeptide O HUGO:GNAO1 HGNC:4389 ENTREZ:2775 UNIPROT:P09471 GENECARDS:GNAO1 REACTOME:55350 KEGG:2775 ATLASONC:GC_GNAO1 WIKI:GNAO1 guanine nucleotide binding protein (G protein) q polypeptide HUGO:GNAQ HGNC:4390 ENTREZ:2776 UNIPROT:P50148 GENECARDS:GNAQ REACTOME:55454 KEGG:2776 ATLASONC:GNAQID43280ch9q21 WIKI:GNAQ Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21640127 References_end</body> </html> </notes> <label text="Gαo*"/> <bbox w="40.0" h="20.0" x="13711.0" y="831.0"/> </glyph> <glyph class="simple chemical" id="wca1_wca1_s1190_wca1_wca1_sa624"> <label text="GDP"/> <bbox w="25.0" h="25.0" x="13718.5" y="858.5"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1341_wca1_wca1_csa65" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:KIF3A:KIF3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11208056 References_end</body> </html> </notes> <label text="KIF3A:KIF3B"/> <bbox w="100.0" h="120.0" x="12981.0" y="946.0"/> <glyph class="macromolecule" id="wca1_wca1_s756_wca1_wca1_sa536"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Kinesin family member 3A HUGO:KIF3A HGNC:6319 ENTREZ:11127 UNIPROT:Q9Y496 GENECARDS:KIF3A REACTOME:58019 KEGG:11127 WIKI:KIF3A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11208056 PMID:14603322 References_end Identifiers_begin: Kinesin family member 3A HUGO:KIF3A HGNC:6319 ENTREZ:11127 UNIPROT:Q9Y496 GENECARDS:KIF3A REACTOME:58019 KEGG:11127 WIKI:KIF3A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11208056 PMID:14603322 References_end</body> </html> </notes> <label text="KIF3A"/> <bbox w="80.0" h="40.0" x="12991.0" y="956.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1340_wca1_wca1_sa637"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Kinesin family member 3B HUGO:KIF3B HGNC:6320 ENTREZ:9371 UNIPROT:O15066 GENECARDS:KIF3B REACTOME:58021 KEGG:9371 ATLASONC:GC_KIF3B WIKI:KIF3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11208056 PMID:14603322 References_end Identifiers_begin: Kinesin family member 3B HUGO:KIF3B HGNC:6320 ENTREZ:9371 UNIPROT:O15066 GENECARDS:KIF3B REACTOME:58021 KEGG:9371 ATLASONC:GC_KIF3B WIKI:KIF3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11208056 PMID:14603322 References_end</body> </html> </notes> <label text="KIF3B"/> <bbox w="80.0" h="40.0" x="12991.0" y="998.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1497_wca1_wca1_csa25" compartmentRef="wca1_wca1_c4_wca1_wca1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK1_epsilon_*:E-Cadherin*:LRP5_6*:p120* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20940130 PMID:21606194 s_wca1_re25:(MAP:survival) PMID:21606194 PMID:19705439 References_end</body> </html> </notes> <label text="CK1ε*:E-Cadherin*:LRP5_6*:p120*"/> <bbox w="225.0" h="189.0" x="13571.0" y="109.0"/> <glyph class="macromolecule" id="wca1_wca1_s1498_wca1_wca1_sa139"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="13574.0" y="177.0"/> <glyph class="state variable" id="_baf9146d-ce51-43c9-9a1e-707b039ce5d7"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="13556.5" y="196.96019"/> </glyph> <glyph class="state variable" id="_7eeae01c-1372-4927-894f-fcff0b4e27e0"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="13596.532" y="172.0"/> </glyph> <glyph class="state variable" id="_22587511-82a2-430c-bdca-246be39e434d"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="13636.5" y="172.26846"/> </glyph> <glyph class="state variable" id="_b89a5c5e-34e7-4633-bda7-fb5ad74398ae"> <state value="" variable="S1496"/> <bbox w="35.0" h="10.0" x="13635.882" y="222.0"/> </glyph> <glyph class="state variable" id="_7e9720e4-67cb-4200-91fa-0eb6582dba60"> <state value="" variable="T1530"/> <bbox w="35.0" h="10.0" x="13595.6045" y="222.0"/> </glyph> <glyph class="state variable" id="_a6ccd4db-63fa-403e-8256-82b4bbbd8ea3"> <state value="" variable="S1533"/> <bbox w="35.0" h="10.0" x="13556.74" y="222.0"/> </glyph> <glyph class="unit of information" id="_0f62f39a-aa0b-46c8-a9d9-5ac0815b9d3b"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="13591.5" y="172.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1499_wca1_wca1_sa143"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="53.0" h="123.0" x="13657.0" y="119.0"/> <glyph class="state variable" id="_07854ec2-6670-4d81-a2e0-346c362481c4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13705.0" y="114.0"/> </glyph> <glyph class="state variable" id="_9c343197-6999-46fa-90a1-cf9873352bef"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="13642.845" y="114.0"/> </glyph> <glyph class="state variable" id="_2740bd34-de2f-41a6-beb9-60e3cf0588f6"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="13695.0" y="114.660416"/> </glyph> <glyph class="state variable" id="_f840ec18-bd16-4153-8741-095e35dd558a"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="13693.069" y="237.0"/> </glyph> <glyph class="state variable" id="_67828f49-88ac-4812-b6a9-94c2ebea9982"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="13642.159" y="237.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1500_wca1_wca1_sa144"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="13711.0" y="200.0"/> <glyph class="state variable" id="_1cc975a8-6657-441d-88fb-26e0a8f33238"> <state value="" variable="S268"/> <bbox w="30.0" h="10.0" x="13696.492" y="195.0"/> </glyph> <glyph class="state variable" id="_3dd494d6-6fd9-4529-872e-88dbef54a28d"> <state value="" variable="S269"/> <bbox w="30.0" h="10.0" x="13736.032" y="195.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1501_wca1_wca1_sa145"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="13709.0" y="240.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1502_wca1_wca1_csa27" compartmentRef="wca1_wca1_c4_wca1_wca1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:CK1_epsilon_*:CK1_gamma_*:DVL*:E-Cadherin*:FZD*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:_beta_-Arrestin2*:p120* Identifiers_end References_begin: s_wca1_re28(MAP:survival): PMID:20006983 PMID:16965538 PMID:210606194 PMID:20093472 PMID:21796133 Phosphorylation of DVL by CK1 epsilon. Activation of CK1 epsilon by unknown factor An acidic environment is required for phosphorylation of DVL and LRP5/6 s_wca1_re32:(MAP:survival) PMID:17569865 PMID:20229235 References_end</body> </html> </notes> <label text="AMER1*:CK1ε*:CK1γ*:DVL*:E-Cadherin*:FZD*:Gβ*:Gγ*:LRP5_6*:PRR*:WNT*:β-Arrestin2*:p120*"/> <bbox w="321.5" h="231.0" x="14283.5" y="107.0"/> <glyph class="macromolecule" id="wca1_wca1_s1503_wca1_wca1_sa156"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="53.0" h="123.0" x="14426.5" y="122.0"/> <glyph class="state variable" id="_9ae78c09-8f59-4b7b-80fe-593df346cb33"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14474.5" y="117.0"/> </glyph> <glyph class="state variable" id="_e11c5aad-4c38-40be-9ef0-8dc7ddb675ec"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="14412.345" y="117.0"/> </glyph> <glyph class="state variable" id="_d26bd7fb-aad9-4848-95e9-27a0964cc1b5"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="14464.5" y="117.660416"/> </glyph> <glyph class="state variable" id="_e7661302-77d9-45e0-9150-5eb7ac9bb72c"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="14462.569" y="240.0"/> </glyph> <glyph class="state variable" id="_68ea5995-5829-430f-81c4-3703c3788940"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="14411.659" y="240.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1504_wca1_wca1_sa157"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="14480.5" y="203.0"/> <glyph class="state variable" id="_ddab1b56-73d9-4730-a9b0-6effe9ad4ccb"> <state value="" variable="S268"/> <bbox w="30.0" h="10.0" x="14465.992" y="198.0"/> </glyph> <glyph class="state variable" id="_5a369a01-42d5-4364-9f31-c0725ddc4c2c"> <state value="" variable="S269"/> <bbox w="30.0" h="10.0" x="14505.532" y="198.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1505_wca1_wca1_sa158"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="14478.5" y="243.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s271_wca1_wca1_sa159"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="14346.0" y="174.0"/> <glyph class="state variable" id="_babb5d31-6038-4330-961e-8e5b31c5077f"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="14328.5" y="193.96019"/> </glyph> <glyph class="state variable" id="_32126018-cf43-40c7-b1b4-b7a1fc4d9641"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="14368.532" y="169.0"/> </glyph> <glyph class="state variable" id="_6eb58db6-d7bb-4712-811f-4c52d3ebebb6"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="14408.5" y="169.26846"/> </glyph> <glyph class="state variable" id="_2114533b-02ef-4d62-b1f2-d838d6730d26"> <state value="" variable="S1496"/> <bbox w="35.0" h="10.0" x="14407.882" y="219.0"/> </glyph> <glyph class="state variable" id="_216b974d-76a8-4136-822f-ca0ad93f78a4"> <state value="" variable="T1530"/> <bbox w="35.0" h="10.0" x="14367.6045" y="219.0"/> </glyph> <glyph class="state variable" id="_8ff25421-b227-433d-8c48-0a53f13c0c71"> <state value="" variable="S1533"/> <bbox w="35.0" h="10.0" x="14328.74" y="219.0"/> </glyph> <glyph class="unit of information" id="_690d4344-4165-49b3-881e-0d580785ef38"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14363.5" y="169.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1506_wca1_wca1_sa160"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="14346.0" y="218.0"/> <glyph class="unit of information" id="_c5b0bef4-cbd1-4bf5-afe9-abbb32d3f311"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14363.5" y="213.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1507_wca1_wca1_sa162"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="14346.75" y="266.0"/> <glyph class="state variable" id="_838a9741-1243-4fb4-85dc-df3362fab8bb"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14419.25" y="261.0"/> </glyph> <glyph class="state variable" id="_d4dab812-35f6-4735-91eb-8426c84e2837"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14341.75" y="261.0"/> </glyph> <glyph class="state variable" id="_bbafc596-c80d-4489-9042-85be73a7c12c"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="14411.132" y="301.0"/> </glyph> <glyph class="state variable" id="_bfab068d-7cc6-458e-8185-c8c641511e29"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14341.75" y="261.0"/> </glyph> <glyph class="state variable" id="_19ea2e52-784c-45ba-af69-667755dff6c7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14421.75" y="261.0"/> </glyph> <glyph class="state variable" id="_78d3b2bc-6aa4-478a-b782-87500a399c78"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14421.384" y="261.0"/> </glyph> <glyph class="state variable" id="_aa8476ac-ac01-42c2-b29c-7c297c29a15b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14421.75" y="301.0"/> </glyph> <glyph class="state variable" id="_cd8fd61d-08e3-4d31-83c7-5c727a47b65a"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="14331.75" y="300.7223"/> </glyph> <glyph class="state variable" id="_77c9b888-7b9c-4871-8f27-c35621b43b29"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14341.75" y="301.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1508_wca1_wca1_sa408"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1γ*"/> <bbox w="80.0" h="40.0" x="14480.5" y="159.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1509_wca1_wca1_sa548"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="14432.75" y="284.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1510_wca1_wca1_sa549"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="14472.75" y="284.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1511_wca1_wca1_sa555"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="14515.5" y="284.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1512_wca1_wca1_sa582"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="14502.0" y="113.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1513_wca1_wca1_sa604"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="14362.0" y="153.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1514_wca1_wca1_sa654"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end</body> </html> </notes> <label text="PRR*"/> <bbox w="50.0" h="40.0" x="14294.182" y="206.18182"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1651_wca1_wca1_csa69" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC:Microtubules Identifiers_end References_begin: s_wca1_re74:(MAP:survival) PMID:21498506 PMID:17925382 s_wca1_re75:(MAP:survival) PMID:17925383 References_end</body> </html> </notes> <label text="APC:Microtubules"/> <bbox w="100.0" h="120.0" x="13342.0" y="1201.0"/> <glyph class="phenotype" id="wca1_wca1_s1612_wca1_wca1_sa687"> <label text="Microtubules"/> <bbox w="80.0" h="30.0" x="13351.0" y="1210.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1652_wca1_wca1_sa688"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="13350.75" y="1245.0"/> <glyph class="state variable" id="_b07dc577-7d39-4015-867e-2213f1b4d587"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="13412.632" y="1280.0"/> </glyph> <glyph class="state variable" id="_6fe5935a-03ae-492a-bc31-4a4fe104e12f"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="13333.742" y="1240.0"/> </glyph> <glyph class="state variable" id="_b6c68909-3e10-44bf-8b55-fc9852a068b8"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="13413.25" y="1240.2147"/> </glyph> <glyph class="state variable" id="_48372d2c-75f7-4d1b-b592-d2bad22d441a"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="13373.154" y="1280.0"/> </glyph> <glyph class="state variable" id="_393422ec-03d8-422b-8594-d0ce33ba527b"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="13373.282" y="1240.0"/> </glyph> <glyph class="state variable" id="_00d03be3-ea74-4900-8f0f-d2b2480d61d9"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="13333.25" y="1279.7223"/> </glyph> <glyph class="state variable" id="_61b3d98f-69a4-4306-a993-03e9775001ac"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13425.75" y="1240.0"/> </glyph> <glyph class="state variable" id="_ada16e36-19be-4077-b7ae-ff960cdf6c34"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="13413.25" y="1279.1306"/> </glyph> <glyph class="state variable" id="_fab293fe-ef0b-4e65-9fe3-d3500e3a4877"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="13333.25" y="1279.7223"/> </glyph> <glyph class="state variable" id="_a304a8d9-fb80-4396-93ae-e48cee9bc79a"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13338.742" y="1240.0"/> </glyph> <glyph class="state variable" id="_2b1e9f1f-26c1-4b62-aca0-92f5aca554e9"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="13333.742" y="1240.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1690_wca1_wca1_csa70" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CyclinY*:PFTK* Identifiers_end References_begin: s_wca1_re36(MAP:survival): PMID:20229235 PMID:18077588 PMID:20059949 PMID:20627573 ANNOTATION:GSK3 phosphorylates first LRP @ S1490 followed by CK1 in the repeat PPSP A ANNOTATION:CYCLINY/PFTK complex is able to phosphorylate s1490 on LRP6 which primes the receptor for CK1 phosphorylisation. The complex is present during G2/M phase and stimulates wnt signalling it has synergetic effect together with the wnt ligand WNT/b-catenin signalling oscillates durring cell cycle and peaks at G2/M References_end</body> </html> </notes> <label text="CyclinY*:PFTK*"/> <bbox w="100.0" h="120.0" x="14593.0" y="470.0"/> <glyph class="macromolecule" id="wca1_wca1_s1688_wca1_wca1_sa723"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin Y HUGO:CCNY HGNC:23354 ENTREZ:219771 UNIPROT:Q8ND76 GENECARDS:CCNY KEGG:219771 ATLASONC:GC_CCNY WIKI:CCNY Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CyclinY*"/> <bbox w="80.0" h="40.0" x="14604.0" y="483.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1689_wca1_wca1_sa724"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cyclin-dependent kinase 14 HUGO:CDK14 HGNC:8883 ENTREZ:5218 UNIPROT:O94921 GENECARDS:CDK14 KEGG:5218 ATLASONC:GC_CDK14 WIKI:CDK14 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20059949 PMID:20627573 References_end</body> </html> </notes> <label text="PFTK*"/> <bbox w="80.0" h="40.0" x="14604.0" y="527.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1696_wca1_wca1_csa71" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:5T4*:LRP5_6* Identifiers_end References_begin: s_wca1_re77(MAP:survival): PMID:22100263 5T4 forms complex with LRP6 resulting in inhibition of the canonical wnt References_end</body> </html> </notes> <label text="5T4*:LRP5_6*"/> <bbox w="100.0" h="120.0" x="15020.625" y="1304.0"/> <glyph class="macromolecule" id="wca1_wca1_s1693_wca1_wca1_sa727"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="15033.375" y="1350.5"/> <glyph class="state variable" id="_14632026-b634-46b9-bed1-b5d609731129"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="15015.875" y="1370.4602"/> </glyph> <glyph class="state variable" id="_3cbcfdd3-7906-4af2-9da8-11369a3405f0"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="15055.907" y="1345.5"/> </glyph> <glyph class="state variable" id="_16cd2b6b-bc52-4992-b16b-b9c3ae00f91c"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="15095.875" y="1345.7684"/> </glyph> <glyph class="state variable" id="_205e4850-94d3-4ac5-8090-2cb66880560c"> <state value="" variable="S1496"/> <bbox w="35.0" h="10.0" x="15095.257" y="1395.5"/> </glyph> <glyph class="state variable" id="_6be3f0bb-9f32-426e-bf56-a9e3af755c96"> <state value="" variable="T1530"/> <bbox w="35.0" h="10.0" x="15054.9795" y="1395.5"/> </glyph> <glyph class="state variable" id="_82db9005-3003-4a70-9ac1-2b39b7f6bdb6"> <state value="" variable="S1533"/> <bbox w="35.0" h="10.0" x="15016.115" y="1395.5"/> </glyph> <glyph class="unit of information" id="_d5c5721d-0ba9-4106-9682-6a1f75aee984"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="15050.875" y="1345.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1695_wca1_wca1_sa728"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: trophoblast glycoprotein HUGO:TPBG HGNC:12004 ENTREZ:7162 UNIPROT:Q13641 GENECARDS:TPBG KEGG:7162 ATLASONC:GC_TPBG WIKI:TPBG Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: It's a glycoprotein and is produced during embryogenesis PMID:17484803 References_end</body> </html> </notes> <label text="5T4*"/> <bbox w="80.0" h="40.0" x="15030.875" y="1307.5"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1699_wca1_wca1_csa72" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DVL*:IDAX* Identifiers_end References_begin: s_wca1_re79:(MAP:survival) PMID:11113207 PMID:18931698 References_end</body> </html> </notes> <label text="DVL*:IDAX*"/> <bbox w="100.0" h="120.0" x="13288.0" y="334.0"/> <glyph class="macromolecule" id="wca1_wca1_s1701_wca1_wca1_sa731"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: CXXC finger protein 4 HUGO:CXXC4 HGNC:24593 ENTREZ:80319 UNIPROT:Q9H2H0 GENECARDS:CXXC4 KEGG:80319 ATLASONC:GC_CXXC4 WIKI:CXXC4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11113207 References_end</body> </html> </notes> <label text="IDAX*"/> <bbox w="80.0" h="40.0" x="13298.0" y="341.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1700_wca1_wca1_sa732"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="13298.0" y="383.0"/> <glyph class="state variable" id="_96ab2547-2979-40f9-9923-e62f9666c894"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13373.0" y="378.0"/> </glyph> <glyph class="state variable" id="_60c5674e-86cc-4e5d-b696-86de72a81774"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13293.0" y="378.0"/> </glyph> <glyph class="state variable" id="_6a4be48d-d1e9-4553-b626-614915ffd1fd"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="13362.382" y="418.0"/> </glyph> <glyph class="state variable" id="_ffc16de9-8f14-43c5-af9f-7ed29a3932d4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13293.0" y="378.0"/> </glyph> <glyph class="state variable" id="_8f91bb29-4577-42ee-8673-76a93fe90d24"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13373.0" y="378.0"/> </glyph> <glyph class="state variable" id="_302a2f28-27cb-4617-8e7d-afb4fad2cc9d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13372.634" y="378.0"/> </glyph> <glyph class="state variable" id="_bfe7bf6e-8769-4197-9a18-ba7861f622ac"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13373.0" y="418.0"/> </glyph> <glyph class="state variable" id="_1ee04b48-23eb-4e3f-bdbe-1b904b8b7a15"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="13283.0" y="417.7223"/> </glyph> <glyph class="state variable" id="_4d2bfcc2-2f07-4db0-bad4-50d7b52ccecb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13293.0" y="418.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1702_wca1_wca1_csa12" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:APC:AXIN*:CK1_alpha_*:GSK3*:PtdIns Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17143292 s_wca1_re19:(MAP:survival) PMID:17318175 s_wca1_re34(MAP:survival): PMID:21498506 Membrane-bound AMER1 acts as scaffold and brings APC to the membrane References_end</body> </html> </notes> <label text="(Destruction_complex)"/> <bbox w="192.0" h="163.0" x="12821.5" y="227.5"/> <glyph class="macromolecule" id="wca1_wca1_s2_wca1_wca1_sa56"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="12832.5" y="281.5"/> <glyph class="state variable" id="_56a3d741-8d77-4e13-a352-1a29c17c0ccf"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="12820.492" y="276.5"/> </glyph> <glyph class="state variable" id="_445b54ea-fa84-4ffe-928c-83f6ede731ba"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="12860.032" y="276.5"/> </glyph> <glyph class="state variable" id="_4715eaca-4589-4314-b080-8adc4b5b4fea"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="12897.5" y="276.71478"/> </glyph> <glyph class="state variable" id="_67e2254a-818b-487d-9c82-5a689fe58033"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="12896.882" y="316.5"/> </glyph> <glyph class="state variable" id="_4259d139-5e4c-4d0a-b3c6-1ebb3a19685d"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="12857.404" y="316.5"/> </glyph> <glyph class="state variable" id="_1a0cf674-3333-42c1-8ca9-973f5f8c084c"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="12817.5" y="316.2223"/> </glyph> <glyph class="state variable" id="_c7a23b64-4549-4f07-9528-385188c787bc"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="12859.904" y="316.5"/> </glyph> <glyph class="state variable" id="_370f2da5-d1ae-49b7-815a-253256a79dea"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="12899.382" y="316.5"/> </glyph> <glyph class="state variable" id="_f8e8c198-92d6-4839-8ade-a81fed7cf353"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12905.0" y="276.71478"/> </glyph> <glyph class="state variable" id="_71217994-9a1a-4aae-87c7-7947d5bec27e"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12820.0" y="316.2223"/> </glyph> <glyph class="state variable" id="_e4500c89-bbe4-40ab-9b8a-2f8efa49898d"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12825.492" y="276.5"/> </glyph> <glyph class="state variable" id="_08e12bf5-203b-4075-adc6-a17c333fef3b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12827.5" y="276.5"/> </glyph> <glyph class="state variable" id="_1b2d76eb-74a4-464f-9b54-0d827fa2a82b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12907.5" y="276.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s80_wca1_wca1_sa57"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="12832.5" y="325.5"/> <glyph class="state variable" id="_ce0f6eb7-eded-4553-b951-48aaf3634f43"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="12894.382" y="360.5"/> </glyph> <glyph class="state variable" id="_c7918436-8b1b-448e-a397-824cdf50838e"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="12815.492" y="320.5"/> </glyph> <glyph class="state variable" id="_6f65f026-9fdf-4c62-b18e-b8f344d52e49"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="12895.0" y="320.71478"/> </glyph> <glyph class="state variable" id="_729bd7f6-71b0-4d46-9e82-233b5d47890e"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="12854.904" y="360.5"/> </glyph> <glyph class="state variable" id="_a8903101-f063-4112-a7fc-b43058b6dc4a"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="12855.032" y="320.5"/> </glyph> <glyph class="state variable" id="_e3d2d130-894a-482c-9025-6fddf3182141"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="12815.0" y="360.2223"/> </glyph> <glyph class="state variable" id="_5451346a-4f42-454e-83a2-e82eb54c3418"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12907.5" y="320.5"/> </glyph> <glyph class="state variable" id="_a8183760-a858-4ac9-9de6-2dc281002da8"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="12895.0" y="359.63065"/> </glyph> <glyph class="state variable" id="_5df36737-640f-4f5f-855f-9ca71b3f2f21"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="12815.0" y="360.2223"/> </glyph> <glyph class="state variable" id="_2217fcdc-a12c-4922-95fb-459601af2fd4"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12820.492" y="320.5"/> </glyph> <glyph class="state variable" id="_66950f45-7b9a-4225-a281-1ab83e065ed4"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="12815.492" y="320.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s4_wca1_wca1_sa58"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="12916.5" y="237.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s539_wca1_wca1_sa427"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="12832.5" y="240.0"/> </glyph> <glyph class="simple chemical" id="wca1_wca1_s1656_wca1_wca1_sa691"> <label text="PtdIns(4,5)-P2"/> <bbox w="70.0" h="25.0" x="12928.0" y="286.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1657_wca1_wca1_sa692"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="12920.0" y="315.25"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1703_wca1_wca1_csa17" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC:AXIN*:CK1_alpha_*:GSK3*:PPP1C*:PPP1R* Identifiers_end References_begin: s_wca1_re16:(MAP:survival) PMID:17318175 PMID:19581931 References_end</body> </html> </notes> <label text="(Destruction_complex_PP1)"/> <bbox w="257.0" h="168.0" x="12978.0" y="510.5"/> <glyph class="macromolecule" id="wca1_wca1_s1484_wca1_wca1_sa96"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="12985.0" y="609.5"/> <glyph class="state variable" id="_e330369b-9e11-4b42-a398-448caa97e6af"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="13046.882" y="644.5"/> </glyph> <glyph class="state variable" id="_80b5d771-5f1a-4acf-94fc-38501f6bafa2"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="12967.992" y="604.5"/> </glyph> <glyph class="state variable" id="_087e175e-a81b-4996-a148-ed38c77afeae"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="13047.5" y="604.7148"/> </glyph> <glyph class="state variable" id="_32613e56-616e-423a-9b10-6449c18a31d8"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="13007.404" y="644.5"/> </glyph> <glyph class="state variable" id="_467b70ff-4ff5-4df4-870d-e8f2513d5ff6"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="13007.532" y="604.5"/> </glyph> <glyph class="state variable" id="_6d0c31a9-ba2d-4faf-89a5-45aba7503900"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="12967.5" y="644.2223"/> </glyph> <glyph class="state variable" id="_6d1d7344-8842-4854-81e3-010d8fcd55df"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13060.0" y="604.5"/> </glyph> <glyph class="state variable" id="_7e20964e-5761-4135-aa5c-cbd0c2ec03bf"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="13047.5" y="643.6307"/> </glyph> <glyph class="state variable" id="_b5852dc2-45c8-470b-b4c9-9c48d52da92b"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="12967.5" y="644.2223"/> </glyph> <glyph class="state variable" id="_225acba3-b944-4e7d-b682-e97345435e26"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12972.992" y="604.5"/> </glyph> <glyph class="state variable" id="_e7b95bf2-d989-4f14-8b18-5b64f4451e3e"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="12967.992" y="604.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1485_wca1_wca1_sa89"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 1 regulatory (inhibitor) subunit 1A HUGO:PPP1R1A HGNC:9286 ENTREZ:5502 UNIPROT:Q13522 GENECARDS:PPP1R1A KEGG:5502 ATLASONC:GC_PPP1R1A WIKI:PPP1R1A protein phosphatase 1 regulatory (inhibitor) subunit 1B HUGO:PPP1R1B HGNC:9287 ENTREZ:84152 UNIPROT:Q9UD71 GENECARDS:PPP1R1B REACTOME:57451 KEGG:84152 ATLASONC:PPP1R1BID44096ch17q12 WIKI:PPP1R1B protein phosphatase 1 regulatory (inhibitor) subunit 1C HUGO:PPP1R1C HGNC:14940 ENTREZ:151242 UNIPROT:Q8WVI7 GENECARDS:PPP1R1C KEGG:151242 ATLASONC:GC_PPP1R1C WIKI:PPP1R1C protein phosphatase 1 regulatory (inhibitor) subunit 2 HUGO:PPP1R2 HGNC:9288 ENTREZ:5504 UNIPROT:P41236 GENECARDS:PPP1R2 KEGG:5504 ATLASONC:GC_PPP1R2 WIKI:PPP1R2 protein phosphatase 1 regulatory subunit 3A HUGO:PPP1R3A HGNC:9291 ENTREZ:5506 UNIPROT:Q16821 GENECARDS:PPP1R3A KEGG:5506 ATLASONC:GC_PPP1R3A WIKI:PPP1R3A protein phosphatase 1 regulatory subunit 3B HUGO:PPP1R3B HGNC:14942 ENTREZ:79660 UNIPROT:Q86XI6 GENECARDS:PPP1R3B KEGG:79660 ATLASONC:GC_PPP1R3B WIKI:PPP1R3B protein phosphatase 1 regulatory subunit 3C HUGO:PPP1R3C HGNC:9293 ENTREZ:5507 UNIPROT:Q9UQK1 GENECARDS:PPP1R3C KEGG:5507 ATLASONC:GC_PPP1R3C WIKI:PPP1R3C protein phosphatase 1 regulatory (inhibitor) subunit 3D HUGO:PPP1R3D HGNC:9294 ENTREZ:5509 UNIPROT:O95685 GENECARDS:PPP1R3D KEGG:5509 ATLASONC:GC_PPP1R3D WIKI:PPP1R3D protein phosphatase 1 regulatory subunit 3E HUGO:PPP1R3E HGNC:14943 ENTREZ:90673 UNIPROT:Q9H7J1 GENECARDS:PPP1R3E ATLASONC:GC_PPP1R3E WIKI:PPP1R3E protein phosphatase 1 regulatory subunit 3F HUGO:PPP1R3F HGNC:14944 ENTREZ:89801 UNIPROT:Q6ZSY5 GENECARDS:PPP1R3F KEGG:89801 ATLASONC:GC_PPP1R3F WIKI:PPP1R3F protein phosphatase 1 regulatory subunit 3G HUGO:PPP1R3G HGNC:14945 ENTREZ:648791 UNIPROT:B7ZBB8 GENECARDS:PPP1R3G ATLASONC:GC_PPP1R3G WIKI:PPP1R3G protein phosphatase 1 regulatory subunit 7 HUGO:PPP1R7 HGNC:9295 ENTREZ:5510 UNIPROT:Q15435 GENECARDS:PPP1R7 KEGG:5510 ATLASONC:GC_PPP1R7 WIKI:PPP1R7 protein phosphatase 1 regulatory subunit 8 HUGO:PPP1R8 HGNC:9296 ENTREZ:5511 UNIPROT:Q12972 GENECARDS:PPP1R8 KEGG:5511 ATLASONC:PPP1R8ID41811ch1p35 WIKI:PPP1R8 protein phosphatase 1 regulatory subunit 9A HUGO:PPP1R9A HGNC:14946 ENTREZ:55607 UNIPROT:Q9ULJ8 GENECARDS:PPP1R9A KEGG:55607 ATLASONC:GC_PPP1R9A WIKI:PPP1R9A protein phosphatase 1 regulatory subunit 9B HUGO:PPP1R9B HGNC:9298 ENTREZ:84687 UNIPROT:Q96SB3 GENECARDS:PPP1R9B KEGG:84687 ATLASONC:PPP1R9BID51558ch17q21 WIKI:PPP1R9B protein phosphatase 1 regulatory subunit 10 HUGO:PPP1R10 HGNC:9284 ENTREZ:5514 UNIPROT:Q96QC0 GENECARDS:PPP1R10 KEGG:5514 ATLASONC:GC_PPP1R10 WIKI:PPP1R10 protein phosphatase 1 regulatory (inhibitor) subunit 11 HUGO:PPP1R11 HGNC:9285 ENTREZ:6992 UNIPROT:O60927 GENECARDS:PPP1R11 KEGG:6992 ATLASONC:GC_PPP1R11 WIKI:PPP1R11 protein phosphatase 1 regulatory subunit 12A HUGO:PPP1R12A HGNC:7618 ENTREZ:4659 UNIPROT:O14974 GENECARDS:PPP1R12A REACTOME:150515 KEGG:4659 ATLASONC:GC_PPP1R12A WIKI:PPP1R12A protein phosphatase 1 regulatory subunit 12B HUGO:PPP1R12B HGNC:7619 ENTREZ:4660 UNIPROT:O60237 GENECARDS:PPP1R12B REACTOME:150526 KEGG:4660 ATLASONC:GC_PPP1R12B WIKI:PPP1R12B protein phosphatase 1 regulatory subunit 12C HUGO:PPP1R12C HGNC:14947 ENTREZ:54776 UNIPROT:Q9BZL4 GENECARDS:PPP1R12C KEGG:54776 ATLASONC:GC_PPP1R12C WIKI:PPP1R12C protein phosphatase 1 regulatory subunit 13B HUGO:PPP1R13B HGNC:14950 ENTREZ:23368 UNIPROT:Q96KQ4 GENECARDS:PPP1R13B KEGG:23368 ATLASONC:GC_PPP1R13B WIKI:PPP1R13B protein phosphatase 1 regulatory (inhibitor) subunit 14A HUGO:PPP1R14A HGNC:14871 ENTREZ:94274 UNIPROT:Q96A00 GENECARDS:PPP1R14A KEGG:94274 ATLASONC:GC_PPP1R14A WIKI:PPP1R14A protein phosphatase 1 regulatory (inhibitor) subunit 14B HUGO:PPP1R14B HGNC:9057 ENTREZ:26472 UNIPROT:Q96C90 GENECARDS:PPP1R14B KEGG:26472 ATLASONC:GC_PPP1R14B WIKI:PPP1R14B protein phosphatase 1 regulatory (inhibitor) subunit 14C HUGO:PPP1R14C HGNC:14952 ENTREZ:81706 UNIPROT:Q8TAE6 GENECARDS:PPP1R14C KEGG:81706 ATLASONC:GC_PPP1R14C WIKI:PPP1R14C protein phosphatase 1 regulatory (inhibitor) subunit 14D HUGO:PPP1R14D HGNC:14953 ENTREZ:54866 UNIPROT:Q9NXH3 GENECARDS:PPP1R14D KEGG:54866 ATLASONC:GC_PPP1R14D WIKI:PPP1R14D protein phosphatase 1 regulatory subunit 15A HUGO:PPP1R15A HGNC:14375 ENTREZ:23645 UNIPROT:O75807 GENECARDS:PPP1R15A REACTOME:243750 KEGG:23645 ATLASONC:GC_PPP1R15A WIKI:PPP1R15A protein phosphatase 1 regulatory subunit 15B HUGO:PPP1R15B HGNC:14951 ENTREZ:84919 UNIPROT:Q5SWA1 GENECARDS:PPP1R15B KEGG:84919 ATLASONC:GC_PPP1R15B WIKI:PPP1R15B HUGO:PPP1R15A HGNC:14375 ENTREZ:23645 UNIPROT:O75807 GENECARDS:PPP1R15A REACTOME:243750 KEGG:23645 ATLASONC:GC_PPP1R15A WIKI:PPP1R15A protein phosphatase 1 regulatory subunit 16A HUGO:PPP1R16A HGNC:14941 ENTREZ:84988 UNIPROT:Q96I34 GENECARDS:PPP1R16A KEGG:84988 ATLASONC:GC_PPP1R16A WIKI:PPP1R16A protein phosphatase 1 regulatory subunit 16B HUGO:PPP1R16B HGNC:15850 ENTREZ:26051 UNIPROT:Q96T49 GENECARDS:PPP1R16B KEGG:26051 ATLASONC:GC_PPP1R16B WIKI:PPP1R16B protein phosphatase 1 regulatory subunit 17 HUGO:PPP1R17 HGNC:16973 ENTREZ:10842 UNIPROT:O96001 GENECARDS:PPP1R17 KEGG:10842 WIKI:PPP1R17 protein phosphatase 1 regulatory subunit 18 HUGO:PPP1R18 HGNC:29413 ENTREZ:170954 UNIPROT:Q6NYC8 GENECARDS:PPP1R18 KEGG:170954 WIKI:PPP1R18 protein phosphatase 1 regulatory subunit 21 HUGO:PPP1R21 HGNC:30595 ENTREZ:129285 UNIPROT:Q6ZMI0 GENECARDS:PPP1R21 KEGG:129285 WIKI:PPP1R21 protein phosphatase 1 regulatory subunit 26 HUGO:PPP1R26 HGNC:29089 ENTREZ:9858 UNIPROT:Q5T8A7 GENECARDS:PPP1R26 KEGG:9858 ATLASONC:GC_PPP1R26 WIKI:PPP1R26 protein phosphatase 1 regulatory subunit 27 HUGO:PPP1R27 HGNC:16813 ENTREZ:116729 UNIPROT:Q86WC6 GENECARDS:PPP1R27 KEGG:116729 WIKI:PPP1R27 protein phosphatase 1 regulatory subunit 32 HUGO:PPP1R32 HGNC:28869 ENTREZ:220004 UNIPROT:Q7Z5V6 GENECARDS:PPP1R32 KEGG:220004 WIKI:PPP1R32 protein phosphatase 1 regulatory subunit 35 HUGO:PPP1R35 HGNC:28320 ENTREZ:221908 UNIPROT:Q8TAP8 GENECARDS:PPP1R35 KEGG:221908 WIKI:PPP1R35 protein phosphatase 1 regulatory subunit 36 HUGO:PPP1R36 HGNC:20097 ENTREZ:145376 UNIPROT:Q96LQ0 GENECARDS:PPP1R36 KEGG:145376 WIKI:PPP1R36 protein phosphatase 1 regulatory subunit 37 HUGO:PPP1R37 HGNC:27607 ENTREZ:284352 UNIPROT:O75864 GENECARDS:PPP1R37 KEGG:284352 WIKI:PPP1R37 protein phosphatase 1 regulatory subunit 39 HUGO:PPP1R39 GENECARDS:PPP1R39 KEGG:153769 WIKI:PPP1R39 protein phosphatase 1 regulatory subunit 42 HUGO:PPP1R42 HGNC:33732 ENTREZ:286187 UNIPROT:Q7Z4L9 GENECARDS:PPP1R42 KEGG:286187 WIKI:PPP1R42 Identifiers_end Maps_Modules_begin: MAP:cellcycle / MODULE:RB MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20399103 References_end</body> </html> </notes> <label text="PPP1R*"/> <bbox w="80.0" h="40.0" x="13069.5" y="609.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1486_wca1_wca1_sa92"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="12985.0" y="524.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1487_wca1_wca1_sa93"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="13069.5" y="524.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s118_wca1_wca1_sa97"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="12985.0" y="567.5"/> <glyph class="state variable" id="_2b6c49f1-1b31-4cd0-9bcb-9c4df37f266f"> <state value="P" variable="S80"/> <bbox w="30.0" h="10.0" x="12970.492" y="562.5"/> </glyph> <glyph class="state variable" id="_f8320b89-766f-42d2-a3cb-3a89afa38f4e"> <state value="P" variable="S82"/> <bbox w="30.0" h="10.0" x="13010.032" y="562.5"/> </glyph> <glyph class="state variable" id="_441e67e3-ce65-49ed-8c64-252ed4890fcf"> <state value="P" variable="S222"/> <bbox w="35.0" h="10.0" x="13047.5" y="562.7148"/> </glyph> <glyph class="state variable" id="_216ec759-53e4-4725-8fdf-883442a676b8"> <state value="P" variable="S473"/> <bbox w="35.0" h="10.0" x="13046.882" y="602.5"/> </glyph> <glyph class="state variable" id="_d7fb65c3-19f2-49c7-9742-51ae75fb9f2f"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="13009.904" y="602.5"/> </glyph> <glyph class="state variable" id="_4765938a-4127-436d-9f05-a2b0bde0c967"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="12970.0" y="602.2223"/> </glyph> <glyph class="state variable" id="_26e7baff-4c1f-443b-b6ca-1bfc4e326b3b"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="13012.404" y="602.5"/> </glyph> <glyph class="state variable" id="_04bb58f6-7133-42eb-9034-838288ea8f13"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="13051.882" y="602.5"/> </glyph> <glyph class="state variable" id="_d9c7a93e-6910-4306-afab-e1bd5561adad"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="13057.5" y="562.7148"/> </glyph> <glyph class="state variable" id="_c819d61c-8e4c-4364-8f81-08df0e989e8a"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12972.5" y="602.2223"/> </glyph> <glyph class="state variable" id="_8b9ebfe8-8a82-4ac6-8937-5cb298b12273"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12977.992" y="562.5"/> </glyph> <glyph class="state variable" id="_a706b8a6-f6bd-4d85-a350-9b54d72207b3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12980.0" y="562.5"/> </glyph> <glyph class="state variable" id="_734177ae-a8e6-4062-8435-81144ea55e64"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13060.0" y="562.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1488_wca1_wca1_sa88"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Protein phosphatase 1 catalytic subunit alpha isozyme HUGO:PPP1CA HGNC:9281 ENTREZ:5499 UNIPROT:P62136 GENECARDS:PPP1CA REACTOME:61996 KEGG:5499 ATLASONC:GC_PPP1CA WIKI:PPP1CA Protein phosphatase 1 catalytic subunit beta isozyme HUGO:PPP1CB HGNC:9282 ENTREZ:5500 UNIPROT:P62140 GENECARDS:PPP1CB REACTOME:62004 KEGG:5500 ATLASONC:GC_PPP1CB WIKI:PPP1CB Protein phosphatase 1 catalytic subunit gamma isozyme HUGO:PPP1CC HGNC:9283 ENTREZ:5501 UNIPROT:P36873 GENECARDS:PPP1CC REACTOME:62014 KEGG:5501 ATLASONC:GC_PPP1CC WIKI:PPP1CC Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:RB MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20399103 References_end</body> </html> </notes> <label text="PPP1C*"/> <bbox w="80.0" h="40.0" x="13069.5" y="567.5"/> </glyph> <glyph class="macromolecule" id="wca1_s1331_wca1_sa1305"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re34(MAP:survival): PMID:21498506 Membrane-bound AMER1 acts as scaffold and brings APC to the membrane s_wca1_re59:(MAP:survival) PMID:21304492 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="13152.0" y="534.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1704_wca1_wca1_csa13" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:APC:AXIN*:CK1_alpha_*:GSK3*:PtdIns Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17143292 s_wca1_re12:(MAP:survival) PMID:10581160 s_wca1_re16:(MAP:survival) PMID:17318175 PMID:19581931 References_end</body> </html> </notes> <label text="(Destruction_complex)"/> <bbox w="192.0" h="163.0" x="12600.25" y="226.5"/> <glyph class="macromolecule" id="wca1_wca1_s71_wca1_wca1_sa60"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="12609.25" y="280.5"/> <glyph class="state variable" id="_f446c4a1-1a8f-4987-a17d-a0a22aad3d3b"> <state value="P" variable="S80"/> <bbox w="30.0" h="10.0" x="12594.742" y="275.5"/> </glyph> <glyph class="state variable" id="_3ed8023f-fd37-4e04-a5fd-14f66a003ee2"> <state value="P" variable="S82"/> <bbox w="30.0" h="10.0" x="12634.282" y="275.5"/> </glyph> <glyph class="state variable" id="_88177e32-4d8c-4da3-8b89-9ae399e6c2ab"> <state value="P" variable="S222"/> <bbox w="35.0" h="10.0" x="12671.75" y="275.71478"/> </glyph> <glyph class="state variable" id="_1789c516-ed59-4f84-ac69-0991ef68d610"> <state value="P" variable="S473"/> <bbox w="35.0" h="10.0" x="12671.132" y="315.5"/> </glyph> <glyph class="state variable" id="_672aba3c-5d99-446b-a089-a9f37fe0bb21"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="12634.154" y="315.5"/> </glyph> <glyph class="state variable" id="_f45e3bbb-6ef3-410b-97a0-dcc50636bbdb"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="12594.25" y="315.2223"/> </glyph> <glyph class="state variable" id="_0f2eba21-0956-4315-a101-d4f8352a4fb9"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="12636.654" y="315.5"/> </glyph> <glyph class="state variable" id="_3681f2c9-4259-4b21-a077-9cf97a023804"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="12676.132" y="315.5"/> </glyph> <glyph class="state variable" id="_990075ec-398f-47a9-9228-d1fedd867ae2"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12681.75" y="275.71478"/> </glyph> <glyph class="state variable" id="_52bd512d-7f19-4b62-9500-433284997348"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12596.75" y="315.2223"/> </glyph> <glyph class="state variable" id="_cd3574e4-4727-434c-8033-ef8af47921b6"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12602.242" y="275.5"/> </glyph> <glyph class="state variable" id="_ece55daf-791a-425d-aea8-ef1f753eee0a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12604.25" y="275.5"/> </glyph> <glyph class="state variable" id="_d2711276-4b09-4a21-a495-e08e14964ca9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12684.25" y="275.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s68_wca1_wca1_sa61"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="12611.25" y="324.5"/> <glyph class="state variable" id="_9827c114-2661-45a0-9d7a-d9d3f168a454"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="12673.132" y="359.5"/> </glyph> <glyph class="state variable" id="_bc4f9a71-13e8-4bd2-9eb7-d7251114c0f4"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="12594.242" y="319.5"/> </glyph> <glyph class="state variable" id="_ca76acb1-edc4-4fcf-a89d-f1c74b836f8a"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="12673.75" y="319.71478"/> </glyph> <glyph class="state variable" id="_2e20d237-361f-4013-bfd3-aa3e3491c671"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="12633.654" y="359.5"/> </glyph> <glyph class="state variable" id="_63da7b3c-08a3-474c-92a1-fa78f84d17be"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="12633.782" y="319.5"/> </glyph> <glyph class="state variable" id="_2b160c96-2410-421e-8346-8c8d2c4b2852"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="12593.75" y="359.2223"/> </glyph> <glyph class="state variable" id="_2c07de57-85f0-4a50-9457-4ac3e00e91ab"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12686.25" y="319.5"/> </glyph> <glyph class="state variable" id="_2d4d2fe4-7d49-4d29-a1f5-ae9f6aebab7f"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="12673.75" y="358.63065"/> </glyph> <glyph class="state variable" id="_e7c4fef1-a8aa-4b1e-9917-1343fa7e02bf"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="12593.75" y="359.2223"/> </glyph> <glyph class="state variable" id="_0656654b-2b8a-47bc-b48a-a33a9aa3a4e1"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12599.242" y="319.5"/> </glyph> <glyph class="state variable" id="_cdd65692-232f-4cb3-94bd-f7b542ccb53a"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="12594.242" y="319.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s77_wca1_wca1_sa65"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="12693.75" y="236.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s540_wca1_wca1_sa428"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="12606.5" y="237.0"/> </glyph> <glyph class="simple chemical" id="wca1_wca1_s1658_wca1_wca1_sa693"> <label text="PtdIns(4,5)-P2"/> <bbox w="70.0" h="25.0" x="12707.0" y="285.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1659_wca1_wca1_sa694"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="12699.0" y="314.25"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1705_wca1_wca1_csa14" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:APC:AXIN*:CK1_alpha_*:GSK3*:PtdIns Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17143292 s_wca1_re12:(MAP:survival) PMID:10581160 References_end</body> </html> </notes> <label text="(Destruction_complex)"/> <bbox w="192.0" h="163.0" x="12357.0" y="295.5"/> <glyph class="macromolecule" id="wca1_wca1_s87_wca1_wca1_sa62"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="12455.5" y="305.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s85_wca1_wca1_sa64"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="12368.0" y="393.5"/> <glyph class="state variable" id="_970eddf7-86d6-4c2c-b259-4b9e33a0e261"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="12429.882" y="428.5"/> </glyph> <glyph class="state variable" id="_90fa5564-f440-442b-a146-80ad38ed11e9"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="12350.992" y="388.5"/> </glyph> <glyph class="state variable" id="_d66bc69e-860d-4920-bf0c-fd6ab97d0e4d"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="12430.5" y="388.71478"/> </glyph> <glyph class="state variable" id="_7f1325f5-bb46-4ba4-999e-a7637e8492a2"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="12390.404" y="428.5"/> </glyph> <glyph class="state variable" id="_8d3213c7-7c10-414f-86a1-86b0233c02f7"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="12390.532" y="388.5"/> </glyph> <glyph class="state variable" id="_a31c8652-843c-4e39-af8d-454c1d0404fa"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="12350.5" y="428.2223"/> </glyph> <glyph class="state variable" id="_e2ba72e7-2f62-482d-8ab7-bb5600810c42"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12443.0" y="388.5"/> </glyph> <glyph class="state variable" id="_d47c6dde-bc7f-4a3b-94b9-ccfda2c5f8ac"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="12430.5" y="427.63065"/> </glyph> <glyph class="state variable" id="_1e4b1916-54af-4f28-998f-ee75e7665218"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="12350.5" y="428.2223"/> </glyph> <glyph class="state variable" id="_ecd5131a-f76b-4cff-8fbb-bfe4c9c9b3d0"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12355.992" y="388.5"/> </glyph> <glyph class="state variable" id="_3298d3bc-94f9-4cb7-a847-230e7fb6f982"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="12350.992" y="388.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s86_wca1_wca1_sa66"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="12368.0" y="305.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s88_wca1_wca1_sa67"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="12368.0" y="349.5"/> <glyph class="state variable" id="_81bc92b8-be39-408e-86bd-c8a699237038"> <state value="P" variable="S80"/> <bbox w="30.0" h="10.0" x="12353.492" y="344.5"/> </glyph> <glyph class="state variable" id="_829ee11a-8861-48fd-8109-e4a1b14e49b7"> <state value="P" variable="S82"/> <bbox w="30.0" h="10.0" x="12393.032" y="344.5"/> </glyph> <glyph class="state variable" id="_192ee35f-ddf3-4d64-a883-36cccba0d536"> <state value="P" variable="S222"/> <bbox w="35.0" h="10.0" x="12430.5" y="344.71478"/> </glyph> <glyph class="state variable" id="_61e0137f-04a1-435c-bcea-ce744d22b5e2"> <state value="P" variable="S473"/> <bbox w="35.0" h="10.0" x="12429.882" y="384.5"/> </glyph> <glyph class="state variable" id="_3358436d-b774-4a9b-8177-30b63505fa3a"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="12392.904" y="384.5"/> </glyph> <glyph class="state variable" id="_5bd814be-fc09-449a-90ed-aebb30747b60"> <state value="P" variable="S621"/> <bbox w="35.0" h="10.0" x="12350.5" y="384.2223"/> </glyph> <glyph class="state variable" id="_d7cbeafd-b77e-42b7-9c12-66cb6746bc0d"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="12395.404" y="384.5"/> </glyph> <glyph class="state variable" id="_71f82176-606d-4428-a817-59d9fcacdf2f"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="12434.882" y="384.5"/> </glyph> <glyph class="state variable" id="_6b3e70e8-77c9-4b08-b8b3-6449e84d5991"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12440.5" y="344.71478"/> </glyph> <glyph class="state variable" id="_f8ea455c-f62e-426d-aff3-d84c48eef831"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12355.5" y="384.2223"/> </glyph> <glyph class="state variable" id="_5d9c712d-f23b-4bb2-8d69-3b92c256110f"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12360.992" y="344.5"/> </glyph> <glyph class="state variable" id="_f964bc65-ee9d-4269-8456-f5b22a7d6931"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12363.0" y="344.5"/> </glyph> <glyph class="state variable" id="_567ce2a9-34f9-411c-8473-3a9c0c17dd29"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12443.0" y="344.5"/> </glyph> </glyph> <glyph class="simple chemical" id="wca1_wca1_s1660_wca1_wca1_sa695"> <label text="PtdIns(4,5)-P2"/> <bbox w="70.0" h="25.0" x="12466.0" y="351.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1661_wca1_wca1_sa696"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="12458.0" y="380.25"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1706_wca1_wca1_csa1" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:APC:AXIN*:CK1_alpha_*:GSK3*:PtdIns Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17143292 s_wca1_re15:(MAP:survival) PMID:10581160 References_end</body> </html> </notes> <label text="(Destruction_complex)"/> <bbox w="192.0" h="163.0" x="12357.0" y="517.5"/> <glyph class="macromolecule" id="wca1_wca1_s1460_wca1_wca1_sa3"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="12368.0" y="615.5"/> <glyph class="state variable" id="_44062b2d-068c-40da-b65b-f9a3df66c245"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="12429.882" y="650.5"/> </glyph> <glyph class="state variable" id="_9b8d3db4-d80f-446d-9dac-0381ca90ec0a"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="12350.992" y="610.5"/> </glyph> <glyph class="state variable" id="_53ddc264-130a-450c-8de3-1434eeb5c055"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="12430.5" y="610.7148"/> </glyph> <glyph class="state variable" id="_590456f1-13d1-444c-a08d-5e4e341557a5"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="12390.404" y="650.5"/> </glyph> <glyph class="state variable" id="_c25f2beb-aa82-4c94-a989-2339cd7fe676"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="12390.532" y="610.5"/> </glyph> <glyph class="state variable" id="_792154e8-99c8-4312-9f97-6d686d6f1674"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="12350.5" y="650.2223"/> </glyph> <glyph class="state variable" id="_5ecd02db-13d8-460c-8637-2606e5b5f1b5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12443.0" y="610.5"/> </glyph> <glyph class="state variable" id="_c7bb7b38-6ccc-42d9-8431-8188ea36971e"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="12430.5" y="649.6307"/> </glyph> <glyph class="state variable" id="_80d52fb2-dcd8-4d6e-8fe4-cc151b9984f7"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="12350.5" y="650.2223"/> </glyph> <glyph class="state variable" id="_d30f569b-a444-486b-a959-9c3c41cf016f"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12355.992" y="610.5"/> </glyph> <glyph class="state variable" id="_83edf381-9151-4503-9e2a-480c4bb756d8"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="12350.992" y="610.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1461_wca1_wca1_sa4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="12452.0" y="527.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1462_wca1_wca1_sa5"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="12368.0" y="527.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1463_wca1_wca1_sa73"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="12369.0" y="572.5"/> <glyph class="state variable" id="_ef3a180e-e700-406c-b964-f2d24c7874f0"> <state value="P" variable="S80"/> <bbox w="30.0" h="10.0" x="12354.492" y="567.5"/> </glyph> <glyph class="state variable" id="_a9ab5e4b-75e5-4008-9a3f-3a84c784a984"> <state value="P" variable="S82"/> <bbox w="30.0" h="10.0" x="12394.032" y="567.5"/> </glyph> <glyph class="state variable" id="_c25318ad-01e2-4bde-bce7-fd445f176731"> <state value="P" variable="S222"/> <bbox w="35.0" h="10.0" x="12431.5" y="567.7148"/> </glyph> <glyph class="state variable" id="_a10942a8-a5d0-4161-a9cc-ec7c991795a6"> <state value="P" variable="S473"/> <bbox w="35.0" h="10.0" x="12430.882" y="607.5"/> </glyph> <glyph class="state variable" id="_3c21c2d0-8e6d-4a9f-9e74-041fb292d7c0"> <state value="P" variable="S614"/> <bbox w="35.0" h="10.0" x="12391.404" y="607.5"/> </glyph> <glyph class="state variable" id="_aa2f4b08-5640-4379-a18d-084ef75afa2b"> <state value="P" variable="S621"/> <bbox w="35.0" h="10.0" x="12351.5" y="607.2223"/> </glyph> <glyph class="state variable" id="_02c8b2b4-79c9-4f5b-bdb5-129dc3267a3e"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="12396.404" y="607.5"/> </glyph> <glyph class="state variable" id="_0c84e717-7651-4128-9416-4439d6c308bf"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="12435.882" y="607.5"/> </glyph> <glyph class="state variable" id="_aa7622dd-9e12-4406-942b-8ce64c4be3aa"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12441.5" y="567.7148"/> </glyph> <glyph class="state variable" id="_bceeede3-1306-4fbc-9c43-c94c0c7b7a01"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12356.5" y="607.2223"/> </glyph> <glyph class="state variable" id="_0f7afab3-65be-4f6e-939d-f15fda4cd2ea"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12361.992" y="567.5"/> </glyph> <glyph class="state variable" id="_a2b7c88e-64e9-4dc4-a19a-e9bab844ef3c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12364.0" y="567.5"/> </glyph> <glyph class="state variable" id="_2211f740-3ece-4d75-a29c-b746a3091c65"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12444.0" y="567.5"/> </glyph> </glyph> <glyph class="simple chemical" id="wca1_wca1_s1662_wca1_wca1_sa697"> <label text="PtdIns(4,5)-P2"/> <bbox w="70.0" h="25.0" x="12467.0" y="574.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1663_wca1_wca1_sa698"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="12459.0" y="603.25"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1707_wca1_wca1_csa2" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:APC:AXIN*:CK1_alpha_*:GSK3*:PtdIns:_beta_-Catenin* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17143292 s_wca1_re2:(MAP:survival) PMID:12000790 References_end</body> </html> </notes> <label text="(Destruction_complex)"/> <bbox w="193.0" h="191.0" x="12357.0" y="745.0"/> <glyph class="macromolecule" id="wca1_wca1_s9_wca1_wca1_sa7"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="12368.0" y="843.0"/> <glyph class="state variable" id="_8256c71a-1bf2-4be1-83c3-0479debc5841"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="12429.882" y="878.0"/> </glyph> <glyph class="state variable" id="_a37ce954-8d01-41db-8617-6ddc200717df"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="12350.992" y="838.0"/> </glyph> <glyph class="state variable" id="_508349bc-30ba-408a-a0e9-0bfa0d238b88"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="12430.5" y="838.2148"/> </glyph> <glyph class="state variable" id="_06fe0493-bf95-4e94-9f01-93f53bd694a4"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="12390.404" y="878.0"/> </glyph> <glyph class="state variable" id="_7f4ca635-3bd6-4c6f-b6a4-8518c83f056f"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="12390.532" y="838.0"/> </glyph> <glyph class="state variable" id="_82667d9c-42a7-4556-985c-f00eca82c213"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="12350.5" y="877.7223"/> </glyph> <glyph class="state variable" id="_a539b11d-5d8a-4029-9de5-9720325b16b9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12443.0" y="838.0"/> </glyph> <glyph class="state variable" id="_2d213215-ce10-479f-ad45-db29cfc57e3f"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="12430.5" y="877.1307"/> </glyph> <glyph class="state variable" id="_6ad444f9-52b5-440e-9dfa-65673ef2643d"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="12350.5" y="877.7223"/> </glyph> <glyph class="state variable" id="_d58f54eb-0c2d-4a85-b476-f516d92e4a50"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12355.992" y="838.0"/> </glyph> <glyph class="state variable" id="_7b97fd34-1307-49d3-9a99-a4950f18f6bb"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="12350.992" y="838.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s10_wca1_wca1_sa8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="12452.0" y="755.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s11_wca1_wca1_sa9"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="12368.0" y="755.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s12_wca1_wca1_sa10"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="12453.5" y="798.5"/> <glyph class="state variable" id="_9224935f-6e91-48b5-aee3-194bc1db9aa5"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="12480.904" y="833.5"/> </glyph> <glyph class="state variable" id="_da12bc7b-03ee-4f00-ba4a-2083a81f5b24"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="12520.382" y="833.5"/> </glyph> <glyph class="state variable" id="_5469d588-1a63-4d98-81b4-62ca7d21a0d3"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="12521.0" y="793.7148"/> </glyph> <glyph class="state variable" id="_c69d1884-713a-4591-b5db-336ccee800d4"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="12481.032" y="793.5"/> </glyph> <glyph class="state variable" id="_9f308fe5-5027-4e68-8816-5ae8df98aa96"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="12441.492" y="793.5"/> </glyph> <glyph class="state variable" id="_ea16f58c-9212-494b-a9f7-950e8c9da3c0"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="12441.0" y="833.2223"/> </glyph> <glyph class="state variable" id="_743babd0-67da-4729-ad42-175d9b843231"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="12518.5" y="793.7148"/> </glyph> <glyph class="state variable" id="_a4b27363-7264-43cc-bea2-b2de3288834e"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="12518.5" y="793.7148"/> </glyph> <glyph class="state variable" id="_84839d4a-3666-4f8c-baaa-e4c20705f802"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12448.5" y="813.5"/> </glyph> <glyph class="state variable" id="_37e98ad1-2c1c-427c-b6ca-5340ed3e9d5c"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="12438.992" y="793.5"/> </glyph> <glyph class="state variable" id="_8fbd18af-3950-4481-87f2-39559404fcac"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="12518.5" y="793.7148"/> </glyph> <glyph class="state variable" id="_1e141f18-4ec0-40fc-baf3-b1324040799c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12448.5" y="805.2157"/> </glyph> <glyph class="state variable" id="_038bcead-e081-4059-9be0-e7a194bcdb97"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="12518.5" y="793.7148"/> </glyph> <glyph class="state variable" id="_afa48743-43fa-4a36-9789-a8393681b063"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12448.5" y="813.5"/> </glyph> <glyph class="state variable" id="_76c6ef67-262e-422d-a3dd-e13214bf4333"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="12517.882" y="833.5"/> </glyph> <glyph class="state variable" id="_a3e81995-396e-44b8-b131-774324ef8d91"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="12518.5" y="793.7148"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s94_wca1_wca1_sa74"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="12370.0" y="798.6875"/> <glyph class="state variable" id="_841e8cc8-27c9-466a-96dc-b7b7b442a4df"> <state value="P" variable="S80"/> <bbox w="30.0" h="10.0" x="12355.492" y="793.6875"/> </glyph> <glyph class="state variable" id="_370e08d4-5631-4f3e-b2dc-308f3c8c13b9"> <state value="P" variable="S82"/> <bbox w="30.0" h="10.0" x="12395.032" y="793.6875"/> </glyph> <glyph class="state variable" id="_a302053e-a49d-42c6-ae20-7ca213d368e8"> <state value="P" variable="S222"/> <bbox w="35.0" h="10.0" x="12432.5" y="793.9023"/> </glyph> <glyph class="state variable" id="_378dd387-1b18-41b7-baaf-4dfe745439bc"> <state value="P" variable="S473"/> <bbox w="35.0" h="10.0" x="12431.882" y="833.6875"/> </glyph> <glyph class="state variable" id="_f717eee0-c5ac-4f2e-903e-d77a328c180c"> <state value="P" variable="S614"/> <bbox w="35.0" h="10.0" x="12392.404" y="833.6875"/> </glyph> <glyph class="state variable" id="_dea67699-32ec-4c98-a60d-368ff0f1a492"> <state value="P" variable="S621"/> <bbox w="35.0" h="10.0" x="12352.5" y="833.4098"/> </glyph> <glyph class="state variable" id="_1a99a493-8cc1-4889-8d7e-b520547b2dfa"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="12397.404" y="833.6875"/> </glyph> <glyph class="state variable" id="_19959202-5f83-4418-97ca-3402575ca682"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="12436.882" y="833.6875"/> </glyph> <glyph class="state variable" id="_90b209a6-ea60-4a03-8c52-f53c18d1438d"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12442.5" y="793.9023"/> </glyph> <glyph class="state variable" id="_4fd8b30f-aa9d-497a-9751-eff6bc8d9d0c"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12357.5" y="833.4098"/> </glyph> <glyph class="state variable" id="_4433d661-428e-4682-b0dc-a0dcc0f2d405"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12362.992" y="793.6875"/> </glyph> <glyph class="state variable" id="_c8ead6a1-69a5-49d3-be0c-6c3794ab0dbb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12365.0" y="793.6875"/> </glyph> <glyph class="state variable" id="_88717888-2477-46ab-b55f-f756ec16c1e4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12445.0" y="793.6875"/> </glyph> </glyph> <glyph class="simple chemical" id="wca1_wca1_s1664_wca1_wca1_sa699"> <label text="PtdIns(4,5)-P2"/> <bbox w="70.0" h="25.0" x="12466.0" y="847.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1665_wca1_wca1_sa700"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="12458.0" y="876.25"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1708_wca1_wca1_csa3" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:APC:AXIN*:CK1_alpha_*:GSK3*:PtdIns:_beta_-Catenin* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17143292 s_wca1_re2:(MAP:survival) PMID:12000790 s_wca1_re3:(MAP:survival) PMID:11955436 References_end</body> </html> </notes> <label text="(Destruction_complex)"/> <bbox w="192.0" h="183.0" x="12357.0" y="979.625"/> <glyph class="macromolecule" id="wca1_wca1_s15_wca1_wca1_sa12"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="12368.0" y="1077.625"/> <glyph class="state variable" id="_5ce83e68-ed86-48e9-a7bc-187fff0a4530"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="12429.882" y="1112.625"/> </glyph> <glyph class="state variable" id="_99959698-ded8-4b7a-bb8f-8e697fcdfe64"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="12350.992" y="1072.625"/> </glyph> <glyph class="state variable" id="_a28d161e-0486-4ab8-901d-9d4071130924"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="12430.5" y="1072.8397"/> </glyph> <glyph class="state variable" id="_5fef33f2-5b81-4927-b324-3dd66983ec38"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="12390.404" y="1112.625"/> </glyph> <glyph class="state variable" id="_6b91ecec-948c-48aa-91d1-26ee39d99e60"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="12390.532" y="1072.625"/> </glyph> <glyph class="state variable" id="_a10b86a0-e8f0-499a-84a3-ccea62671b81"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="12350.5" y="1112.3473"/> </glyph> <glyph class="state variable" id="_1d3207cf-04b1-4255-a277-1ee17b9d87ce"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12443.0" y="1072.625"/> </glyph> <glyph class="state variable" id="_4d48fb29-b638-4170-80cd-4dd1f625b16e"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="12430.5" y="1111.7556"/> </glyph> <glyph class="state variable" id="_898cfe25-2236-429c-8795-719bbba62951"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="12350.5" y="1112.3473"/> </glyph> <glyph class="state variable" id="_0381c58d-380e-428e-bf47-fdb9cfc65820"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12355.992" y="1072.625"/> </glyph> <glyph class="state variable" id="_d51240d1-e33a-4992-ba63-0ced98afaf10"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="12350.992" y="1072.625"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s16_wca1_wca1_sa13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="12452.0" y="989.625"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s17_wca1_wca1_sa14"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="12368.0" y="989.625"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s18_wca1_wca1_sa15"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="12453.5" y="1033.125"/> <glyph class="state variable" id="_80678946-a525-4cf9-af35-e988ae47fcb3"> <state value="P" variable="S45"/> <bbox w="30.0" h="10.0" x="12478.404" y="1068.125"/> </glyph> <glyph class="state variable" id="_686bb58d-42d3-4beb-8817-9dbdd995dfed"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="12520.382" y="1068.125"/> </glyph> <glyph class="state variable" id="_25d2def7-25bb-4352-9ae3-dfb567f2b18f"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="12521.0" y="1028.3397"/> </glyph> <glyph class="state variable" id="_977d88f0-b9e6-4036-84be-f84ac14bf23d"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="12481.032" y="1028.125"/> </glyph> <glyph class="state variable" id="_d7538c95-1dea-4c6c-900b-20f75ee13207"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="12441.492" y="1028.125"/> </glyph> <glyph class="state variable" id="_81906159-dc7a-4c39-8de3-b65d00b4561b"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="12441.0" y="1067.8473"/> </glyph> <glyph class="state variable" id="_fc678764-62c1-4913-8a72-64d403e39108"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="12518.5" y="1028.3397"/> </glyph> <glyph class="state variable" id="_2e4980e0-0fb3-4e3f-a183-8894bcbd7a6d"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="12518.5" y="1028.3397"/> </glyph> <glyph class="state variable" id="_6f8f3496-0bb1-455e-b6dd-591dc119f18f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12448.5" y="1048.125"/> </glyph> <glyph class="state variable" id="_7b5ed1af-dfde-48c7-a742-bea35999859c"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="12438.992" y="1028.125"/> </glyph> <glyph class="state variable" id="_127600a2-e1a6-415f-913c-99806309f9cb"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="12518.5" y="1028.3397"/> </glyph> <glyph class="state variable" id="_53b9c86b-7009-4e02-969b-bdde5f7f2b1f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12448.5" y="1039.8407"/> </glyph> <glyph class="state variable" id="_a8393b16-5a89-49bb-955b-216ef0cbebc4"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="12518.5" y="1028.3397"/> </glyph> <glyph class="state variable" id="_3e36edb7-9ffa-417c-bcfb-0e2dbc943dec"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12448.5" y="1048.125"/> </glyph> <glyph class="state variable" id="_f7ac4bef-84fc-45b3-940a-47adc6c77c39"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="12517.882" y="1068.125"/> </glyph> <glyph class="state variable" id="_aaa2ec50-9cf0-45ec-b6ce-8edea7af554e"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="12518.5" y="1028.3397"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s95_wca1_wca1_sa75"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="12367.0" y="1035.0"/> <glyph class="state variable" id="_4aecff5c-6804-4485-b53b-325aa1888a53"> <state value="P" variable="S80"/> <bbox w="30.0" h="10.0" x="12352.492" y="1030.0"/> </glyph> <glyph class="state variable" id="_709be1dd-b97c-478d-8e8f-06161cc38c7b"> <state value="P" variable="S82"/> <bbox w="30.0" h="10.0" x="12392.032" y="1030.0"/> </glyph> <glyph class="state variable" id="_e0a99b83-ec1f-4626-a600-461f05c6a713"> <state value="P" variable="S222"/> <bbox w="35.0" h="10.0" x="12429.5" y="1030.2147"/> </glyph> <glyph class="state variable" id="_76cb531b-d771-4b18-ac2b-264537cedfb0"> <state value="P" variable="S473"/> <bbox w="35.0" h="10.0" x="12428.882" y="1070.0"/> </glyph> <glyph class="state variable" id="_52838630-0053-4c96-92b5-78589f818e26"> <state value="P" variable="S614"/> <bbox w="35.0" h="10.0" x="12389.404" y="1070.0"/> </glyph> <glyph class="state variable" id="_32fc1604-15a6-4b6f-b8c6-361e9ca2de7e"> <state value="P" variable="S621"/> <bbox w="35.0" h="10.0" x="12349.5" y="1069.7223"/> </glyph> <glyph class="state variable" id="_2339f1c5-cf95-407c-adb9-fefbb706616a"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="12394.404" y="1070.0"/> </glyph> <glyph class="state variable" id="_e7a0faea-de6d-4e1d-83dc-beb64b086ee4"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="12433.882" y="1070.0"/> </glyph> <glyph class="state variable" id="_b1ad6144-c613-48ba-a331-1376803496bf"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12439.5" y="1030.2147"/> </glyph> <glyph class="state variable" id="_28b69951-8a8b-4a8e-82cc-aca6b1fb0c07"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12354.5" y="1069.7223"/> </glyph> <glyph class="state variable" id="_ce8ac8af-a3b6-4c32-b1f7-27fe8e6d095d"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12359.992" y="1030.0"/> </glyph> <glyph class="state variable" id="_28eb4def-9d15-4ec3-a74b-3a22f43e6c98"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12362.0" y="1030.0"/> </glyph> <glyph class="state variable" id="_bbd995ae-d0f8-4a57-b3f2-beceab0f42d4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12442.0" y="1030.0"/> </glyph> </glyph> <glyph class="simple chemical" id="wca1_wca1_s1666_wca1_wca1_sa701"> <label text="PtdIns(4,5)-P2"/> <bbox w="70.0" h="25.0" x="12462.0" y="1077.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1667_wca1_wca1_sa702"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="12454.0" y="1106.25"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1709_wca1_wca1_csa4" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:APC:AXIN*:CK1_alpha_*:GSK3*:PtdIns:_beta_-Catenin* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17143292 s_wca1_re3:(MAP:survival) PMID:11955436 References_end</body> </html> </notes> <label text="(Destruction_complex)"/> <bbox w="192.0" h="184.0" x="12357.0" y="1199.9375"/> <glyph class="macromolecule" id="wca1_wca1_s21_wca1_wca1_sa17"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="12368.0" y="1297.9375"/> <glyph class="state variable" id="_b51a9a75-1059-4146-9dc6-513a9ca99afc"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="12429.882" y="1332.9375"/> </glyph> <glyph class="state variable" id="_c067256f-05d0-4c19-a54e-522f09328363"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="12350.992" y="1292.9375"/> </glyph> <glyph class="state variable" id="_042d1a88-4de8-4555-93b1-ad72157ec3b2"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="12430.5" y="1293.1522"/> </glyph> <glyph class="state variable" id="_c866078d-c3e0-4161-b23d-2aa018786d89"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="12390.404" y="1332.9375"/> </glyph> <glyph class="state variable" id="_803edd1c-df62-4b19-a026-3fc5adb1a555"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="12390.532" y="1292.9375"/> </glyph> <glyph class="state variable" id="_797c92e1-1886-4294-8ed0-9d3fce1593fb"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="12350.5" y="1332.6598"/> </glyph> <glyph class="state variable" id="_f34a0a25-3558-46d5-a8c4-bc800aa814cd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12443.0" y="1292.9375"/> </glyph> <glyph class="state variable" id="_9e5c7cfc-a679-46fb-9afe-34ca20ff28eb"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="12430.5" y="1332.0681"/> </glyph> <glyph class="state variable" id="_881fd35f-e67c-4803-9d13-590351dea081"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="12350.5" y="1332.6598"/> </glyph> <glyph class="state variable" id="_353670f2-18d3-418d-b750-4fbd12e62098"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12355.992" y="1292.9375"/> </glyph> <glyph class="state variable" id="_774955f3-9451-4080-ac07-117dfada7e5b"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="12350.992" y="1292.9375"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s22_wca1_wca1_sa18"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="12452.0" y="1209.9375"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s23_wca1_wca1_sa19"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="12368.0" y="1209.9375"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s24_wca1_wca1_sa20"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="12453.5" y="1253.4375"/> <glyph class="state variable" id="_f148b03a-2546-457c-8a86-7180124aed8a"> <state value="P" variable="S45"/> <bbox w="30.0" h="10.0" x="12478.404" y="1288.4375"/> </glyph> <glyph class="state variable" id="_f131b791-fa99-49bd-98e6-551968446eca"> <state value="P" variable="T41"/> <bbox w="30.0" h="10.0" x="12517.882" y="1288.4375"/> </glyph> <glyph class="state variable" id="_aeef9dc3-d25d-44d1-8a63-79815bf8f279"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="12521.0" y="1248.6522"/> </glyph> <glyph class="state variable" id="_a9d701f0-e963-4f44-a6c4-b6f4310b1eef"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="12481.032" y="1248.4375"/> </glyph> <glyph class="state variable" id="_2acab815-a5e5-48bd-8332-169f6146d0e9"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="12441.492" y="1248.4375"/> </glyph> <glyph class="state variable" id="_e71e6af6-2577-4242-b12f-cab717e48aee"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="12441.0" y="1288.1598"/> </glyph> <glyph class="state variable" id="_3218f44a-2b73-4314-9294-e7f8165a19d5"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="12518.5" y="1248.6522"/> </glyph> <glyph class="state variable" id="_b0e1d201-b001-4f13-bee4-de144c9fb60d"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="12518.5" y="1248.6522"/> </glyph> <glyph class="state variable" id="_361abdb3-f994-4344-94c9-7792d4919f2e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12448.5" y="1268.4375"/> </glyph> <glyph class="state variable" id="_21ab80d7-056c-4200-8465-7ab0f14f06f5"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="12438.992" y="1248.4375"/> </glyph> <glyph class="state variable" id="_af828d51-8c5a-4302-af43-de7b9a0cc301"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="12518.5" y="1248.6522"/> </glyph> <glyph class="state variable" id="_1c979fb1-bb67-49a0-a3c7-18c1f533ea3a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12448.5" y="1260.1532"/> </glyph> <glyph class="state variable" id="_1c102356-dda9-4b66-be50-6dd9b89dbe6d"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="12518.5" y="1248.6522"/> </glyph> <glyph class="state variable" id="_9d362805-fd60-4a8f-9ad0-2e1d55204b4e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12448.5" y="1268.4375"/> </glyph> <glyph class="state variable" id="_95c59012-e22c-4262-92e0-d2a9cd9f7e07"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="12517.882" y="1288.4375"/> </glyph> <glyph class="state variable" id="_dea779b0-dada-4ff4-b2d0-5eb168a68906"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="12518.5" y="1248.6522"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s96_wca1_wca1_sa76"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="12369.0" y="1254.0"/> <glyph class="state variable" id="_442e592d-1313-444a-8666-0d5eef7dccb2"> <state value="P" variable="S80"/> <bbox w="30.0" h="10.0" x="12354.492" y="1249.0"/> </glyph> <glyph class="state variable" id="_93b0816f-a6c6-4078-baa8-2d1f53559aa7"> <state value="P" variable="S82"/> <bbox w="30.0" h="10.0" x="12394.032" y="1249.0"/> </glyph> <glyph class="state variable" id="_1d9937ce-00a4-40d8-83e5-b690bf291270"> <state value="P" variable="S222"/> <bbox w="35.0" h="10.0" x="12431.5" y="1249.2147"/> </glyph> <glyph class="state variable" id="_c2ba16b7-b040-4615-86ce-956f3ee0f031"> <state value="P" variable="S473"/> <bbox w="35.0" h="10.0" x="12430.882" y="1289.0"/> </glyph> <glyph class="state variable" id="_61049afa-394a-49fc-afa4-47fdd8a69181"> <state value="P" variable="S614"/> <bbox w="35.0" h="10.0" x="12391.404" y="1289.0"/> </glyph> <glyph class="state variable" id="_a64c9a8e-6595-42af-866a-c0cab19bbf25"> <state value="P" variable="S621"/> <bbox w="35.0" h="10.0" x="12351.5" y="1288.7223"/> </glyph> <glyph class="state variable" id="_dca32e54-278f-41c6-b48e-b67e3c323c4e"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="12396.404" y="1289.0"/> </glyph> <glyph class="state variable" id="_d130d3c1-825b-48fc-acd2-75b1144a7eeb"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="12435.882" y="1289.0"/> </glyph> <glyph class="state variable" id="_f0fe9716-8424-4f32-b542-09cb98f3e604"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12441.5" y="1249.2147"/> </glyph> <glyph class="state variable" id="_5d65851c-36a7-44e9-af4c-b772710f97ea"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12356.5" y="1288.7223"/> </glyph> <glyph class="state variable" id="_6ae51cd7-9944-49d1-b603-92eccc86e726"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12361.992" y="1249.0"/> </glyph> <glyph class="state variable" id="_a981b66d-e67e-440c-a753-1307f8738242"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12364.0" y="1249.0"/> </glyph> <glyph class="state variable" id="_bce89c14-c288-4913-8f4b-bd8f11e6bc67"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12444.0" y="1249.0"/> </glyph> </glyph> <glyph class="simple chemical" id="wca1_wca1_s1668_wca1_wca1_sa703"> <label text="PtdIns(4,5)-P2"/> <bbox w="70.0" h="25.0" x="12460.0" y="1293.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1669_wca1_wca1_sa704"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="12452.0" y="1322.25"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1710_wca1_wca1_csa5" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:APC:AXIN*:CK1_alpha_*:GSK3*:PtdIns:_beta_-Catenin* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17143292 s_wca1_re4:(MAP:survival) PMID:11955436 References_end</body> </html> </notes> <label text="(Destruction_complex)"/> <bbox w="193.0" h="181.0" x="12357.0" y="1416.25"/> <glyph class="macromolecule" id="wca1_wca1_s27_wca1_wca1_sa22"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="12368.0" y="1514.25"/> <glyph class="state variable" id="_781d0059-8955-4a97-a61b-00655bb54428"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="12429.882" y="1549.25"/> </glyph> <glyph class="state variable" id="_28ca60c1-e060-40ac-a4b6-1a506299f128"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="12350.992" y="1509.25"/> </glyph> <glyph class="state variable" id="_dc0075b6-44de-4cd6-b862-c739b464f1d8"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="12430.5" y="1509.4647"/> </glyph> <glyph class="state variable" id="_b4e3f4d4-3d16-49ce-98e7-983264fc8144"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="12390.404" y="1549.25"/> </glyph> <glyph class="state variable" id="_d4e3b8e9-0ff1-4e40-9f20-dbee05bf289f"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="12390.532" y="1509.25"/> </glyph> <glyph class="state variable" id="_b27ed771-f9dd-4832-8ee5-51e3efcd2d31"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="12350.5" y="1548.9723"/> </glyph> <glyph class="state variable" id="_c7a36b34-2fe6-49ff-838c-e99279295d4e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12443.0" y="1509.25"/> </glyph> <glyph class="state variable" id="_8ac84d5d-c931-4c65-b83e-82e19c8e36bb"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="12430.5" y="1548.3806"/> </glyph> <glyph class="state variable" id="_7f95f6ff-2fbc-4165-97c1-b7f7d3f72e45"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="12350.5" y="1548.9723"/> </glyph> <glyph class="state variable" id="_8f5364ae-9167-48c6-aebb-2af363546189"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12355.992" y="1509.25"/> </glyph> <glyph class="state variable" id="_7fe19ef3-7a49-464a-94e9-fa48cdc34aaf"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="12350.992" y="1509.25"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s28_wca1_wca1_sa23"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="12452.0" y="1426.25"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s29_wca1_wca1_sa24"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="12368.0" y="1426.25"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s30_wca1_wca1_sa25"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="12453.5" y="1469.75"/> <glyph class="state variable" id="_ddc8691a-b43b-4184-9b7f-ce98a0df2b83"> <state value="P" variable="S45"/> <bbox w="30.0" h="10.0" x="12478.404" y="1504.75"/> </glyph> <glyph class="state variable" id="_7da789a0-419c-4923-b542-c74d1fdd07bd"> <state value="P" variable="T41"/> <bbox w="30.0" h="10.0" x="12517.882" y="1504.75"/> </glyph> <glyph class="state variable" id="_31c42bb0-e064-4bec-bc55-bf5d7de0876c"> <state value="P" variable="S37"/> <bbox w="30.0" h="10.0" x="12518.5" y="1464.9647"/> </glyph> <glyph class="state variable" id="_668b3500-b988-4026-a3ec-e2070c56cbeb"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="12481.032" y="1464.75"/> </glyph> <glyph class="state variable" id="_39176283-e024-4d00-af6c-4f1a5d547363"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="12441.492" y="1464.75"/> </glyph> <glyph class="state variable" id="_da9e5ceb-fa9d-41e2-9131-16d84b4d0714"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="12441.0" y="1504.4723"/> </glyph> <glyph class="state variable" id="_2f9415e5-b11d-4f7b-8a77-761361ab0d88"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="12518.5" y="1464.9647"/> </glyph> <glyph class="state variable" id="_5b9f6f3b-39a5-4dbe-adbb-f2729c5d3441"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="12518.5" y="1464.9647"/> </glyph> <glyph class="state variable" id="_5f18d172-eb8b-4359-be11-6fa5d8688aaf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12448.5" y="1484.75"/> </glyph> <glyph class="state variable" id="_9b76d7f6-95e2-4f8e-addf-0f943029d058"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="12438.992" y="1464.75"/> </glyph> <glyph class="state variable" id="_e4fc8caa-6ca1-4480-894d-c0486897f7cf"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="12518.5" y="1464.9647"/> </glyph> <glyph class="state variable" id="_96c5c708-853e-4467-8434-67a83ac5006f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12448.5" y="1476.4657"/> </glyph> <glyph class="state variable" id="_29cd4e42-af6c-44b5-82e6-247011c37d50"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="12518.5" y="1464.9647"/> </glyph> <glyph class="state variable" id="_b68548ae-c52b-4d50-9d8f-ef5da06570e7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12448.5" y="1484.75"/> </glyph> <glyph class="state variable" id="_728761f7-669d-474c-a618-ec941b9c84a2"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="12517.882" y="1504.75"/> </glyph> <glyph class="state variable" id="_a379be20-c397-4625-aa76-fdc1ecf12636"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="12518.5" y="1464.9647"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s97_wca1_wca1_sa77"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="12369.0" y="1471.0"/> <glyph class="state variable" id="_b9cfbc84-8bc0-4f3a-a697-af27d1d059af"> <state value="P" variable="S80"/> <bbox w="30.0" h="10.0" x="12354.492" y="1466.0"/> </glyph> <glyph class="state variable" id="_da651e7d-64a6-4321-aead-f65b641f552a"> <state value="P" variable="S82"/> <bbox w="30.0" h="10.0" x="12394.032" y="1466.0"/> </glyph> <glyph class="state variable" id="_69d17af2-13d6-4b11-95ac-0bf33282b8c1"> <state value="P" variable="S222"/> <bbox w="35.0" h="10.0" x="12431.5" y="1466.2147"/> </glyph> <glyph class="state variable" id="_ac9ff5cb-3b6b-4a2b-85de-bbcfa80a262c"> <state value="P" variable="S473"/> <bbox w="35.0" h="10.0" x="12430.882" y="1506.0"/> </glyph> <glyph class="state variable" id="_a2f01586-3667-4ccd-8386-2239e80a0fc0"> <state value="P" variable="S614"/> <bbox w="35.0" h="10.0" x="12391.404" y="1506.0"/> </glyph> <glyph class="state variable" id="_1afc76e1-79bd-43df-a1fe-b4dec2708155"> <state value="P" variable="S621"/> <bbox w="35.0" h="10.0" x="12351.5" y="1505.7223"/> </glyph> <glyph class="state variable" id="_e7bd403c-a891-4763-835e-6d7e54f3dc81"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="12396.404" y="1506.0"/> </glyph> <glyph class="state variable" id="_de2299f2-7a91-4419-95ef-19837f3e37b0"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="12435.882" y="1506.0"/> </glyph> <glyph class="state variable" id="_74e12a51-ee2d-4e85-80b6-7015919f518f"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12441.5" y="1466.2147"/> </glyph> <glyph class="state variable" id="_b8f3c0a5-71cd-47b2-b590-8b78b9044a35"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12356.5" y="1505.7223"/> </glyph> <glyph class="state variable" id="_22de322a-99a1-4f23-9743-3ea115dd2d44"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12361.992" y="1466.0"/> </glyph> <glyph class="state variable" id="_245fd12c-fd56-46f6-b3f9-d0c1cff0613a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12364.0" y="1466.0"/> </glyph> <glyph class="state variable" id="_73064132-cadb-4c0d-b9a0-742c3eef1091"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12444.0" y="1466.0"/> </glyph> </glyph> <glyph class="simple chemical" id="wca1_wca1_s1670_wca1_wca1_sa705"> <label text="PtdIns(4,5)-P2"/> <bbox w="70.0" h="25.0" x="12465.0" y="1509.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1671_wca1_wca1_sa706"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="12457.0" y="1538.25"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1711_wca1_wca1_csa6" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:APC:AXIN*:CK1_alpha_*:GSK3*:PtdIns:_beta_-Catenin* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17143292 s_wca1_re5:(MAP:survival) PMID:11955436 s_wca1_re6:(MAP:survival) PMID:17910481 s_wca1_re20:(MAP:survival) PMID:19556239 References_end</body> </html> </notes> <label text="(Destruction_complex)"/> <bbox w="192.0" h="179.0" x="12357.0" y="1637.5625"/> <glyph class="macromolecule" id="wca1_wca1_s34_wca1_wca1_sa28"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="12452.0" y="1647.5625"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s35_wca1_wca1_sa29"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="12368.0" y="1647.5625"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1464_wca1_wca1_sa30"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="12453.5" y="1691.0625"/> <glyph class="state variable" id="_c4aa08b0-eb4a-465c-8705-f7d25392ffc8"> <state value="P" variable="S45"/> <bbox w="30.0" h="10.0" x="12478.404" y="1726.0625"/> </glyph> <glyph class="state variable" id="_dab2b8c1-32d8-4620-b839-36d114bdaa39"> <state value="P" variable="T41"/> <bbox w="30.0" h="10.0" x="12517.882" y="1726.0625"/> </glyph> <glyph class="state variable" id="_d4685ca0-cf65-452e-8e6b-df26c8d6325c"> <state value="P" variable="S37"/> <bbox w="30.0" h="10.0" x="12518.5" y="1686.2772"/> </glyph> <glyph class="state variable" id="_85b7c99b-52aa-40e1-8064-7ccf4a42b13d"> <state value="P" variable="S33"/> <bbox w="30.0" h="10.0" x="12478.532" y="1686.0625"/> </glyph> <glyph class="state variable" id="_91f92661-bfdc-400e-a647-37bf35ea0f5f"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="12441.492" y="1686.0625"/> </glyph> <glyph class="state variable" id="_a474051f-e6aa-4463-bf38-904527ceebe9"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="12441.0" y="1725.7848"/> </glyph> <glyph class="state variable" id="_644b781f-03ad-4c0e-b26a-a6f8a29c7cf2"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="12518.5" y="1686.2772"/> </glyph> <glyph class="state variable" id="_5fa2e7ed-9daf-4054-8e5d-6bdab150cb8c"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="12518.5" y="1686.2772"/> </glyph> <glyph class="state variable" id="_169badfe-5c90-4bcf-bc55-90a7d1648026"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12448.5" y="1706.0625"/> </glyph> <glyph class="state variable" id="_dc8b84bd-1de0-4474-89a9-900c08aad56d"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="12438.992" y="1686.0625"/> </glyph> <glyph class="state variable" id="_f91ba8cf-1d1c-4230-ae01-0b707cb717c4"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="12518.5" y="1686.2772"/> </glyph> <glyph class="state variable" id="_b5dfd28b-1971-41d0-9d3d-08ec171b2dad"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12448.5" y="1697.7782"/> </glyph> <glyph class="state variable" id="_4738c484-94a9-45c7-bdcd-96556806741d"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="12518.5" y="1686.2772"/> </glyph> <glyph class="state variable" id="_b7b838a3-f6aa-42fe-a868-2f6133f38856"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12448.5" y="1706.0625"/> </glyph> <glyph class="state variable" id="_827052da-a250-4c63-83c0-2af016309d7e"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="12517.882" y="1726.0625"/> </glyph> <glyph class="state variable" id="_b945ed99-a78b-4ea8-87d5-9bc52b2b183a"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="12518.5" y="1686.2772"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s98_wca1_wca1_sa78"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="12369.0" y="1692.0"/> <glyph class="state variable" id="_3602eb24-b205-45fd-9fec-8d8d94b4b0d4"> <state value="P" variable="S80"/> <bbox w="30.0" h="10.0" x="12354.492" y="1687.0"/> </glyph> <glyph class="state variable" id="_d23c3dcd-e28c-448a-837a-9710f0cd191b"> <state value="P" variable="S82"/> <bbox w="30.0" h="10.0" x="12394.032" y="1687.0"/> </glyph> <glyph class="state variable" id="_49db63f7-6936-40d8-b955-b10ebd2f0692"> <state value="P" variable="S222"/> <bbox w="35.0" h="10.0" x="12431.5" y="1687.2147"/> </glyph> <glyph class="state variable" id="_76779515-ead5-4372-97f8-b5e9442f33e4"> <state value="P" variable="S473"/> <bbox w="35.0" h="10.0" x="12430.882" y="1727.0"/> </glyph> <glyph class="state variable" id="_41437faf-f83b-4d33-b248-1cf0ba75a405"> <state value="P" variable="S614"/> <bbox w="35.0" h="10.0" x="12391.404" y="1727.0"/> </glyph> <glyph class="state variable" id="_f2e430bf-a091-4ade-a82c-18b97cbe9860"> <state value="P" variable="S621"/> <bbox w="35.0" h="10.0" x="12351.5" y="1726.7223"/> </glyph> <glyph class="state variable" id="_b5dbe9db-606e-4147-b460-2ad5647d66a2"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="12396.404" y="1727.0"/> </glyph> <glyph class="state variable" id="_240cf358-5859-4746-89ce-d89c12f1e753"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="12435.882" y="1727.0"/> </glyph> <glyph class="state variable" id="_b5e88b54-ebc8-4aac-a17e-80854dfb9e45"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12441.5" y="1687.2147"/> </glyph> <glyph class="state variable" id="_2525ae22-835a-4259-941a-5eb94f378fd1"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12356.5" y="1726.7223"/> </glyph> <glyph class="state variable" id="_60fc6885-7dda-4b38-b661-4c4526f67b56"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12361.992" y="1687.0"/> </glyph> <glyph class="state variable" id="_62b5008a-04ba-4024-b35c-752bc97cd2d1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12364.0" y="1687.0"/> </glyph> <glyph class="state variable" id="_120e14b9-18c6-458e-be29-212c8a5f6911"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12444.0" y="1687.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s33_wca1_wca1_sa27"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="12368.0" y="1735.5625"/> <glyph class="state variable" id="_63ce1828-8177-4252-95e8-6f055995ddb3"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="12429.882" y="1770.5625"/> </glyph> <glyph class="state variable" id="_612444a9-2437-41bd-a559-f60925d7953e"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="12350.992" y="1730.5625"/> </glyph> <glyph class="state variable" id="_e28aefbb-797a-4ef6-a7bb-e1edbcda0f12"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="12430.5" y="1730.7772"/> </glyph> <glyph class="state variable" id="_cb54cdd4-0e02-4a63-b83d-d415ca58207a"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="12390.404" y="1770.5625"/> </glyph> <glyph class="state variable" id="_a2ac3209-c586-431f-9aae-d4af7ba3ec29"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="12390.532" y="1730.5625"/> </glyph> <glyph class="state variable" id="_2bc3dc86-1dad-4469-bbac-c1b57cd5d7b4"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="12350.5" y="1770.2848"/> </glyph> <glyph class="state variable" id="_a0fc7960-c17c-4bfe-9ad4-f4f8d802288c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12443.0" y="1730.5625"/> </glyph> <glyph class="state variable" id="_f381c4d8-fdf8-4cd1-8c86-51d10fc5baea"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="12430.5" y="1769.6931"/> </glyph> <glyph class="state variable" id="_d065972e-b43e-4134-abfa-9cf6ec4ee4a4"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="12350.5" y="1770.2848"/> </glyph> <glyph class="state variable" id="_923a232a-f08a-4171-85a0-92acbca694c7"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12355.992" y="1730.5625"/> </glyph> <glyph class="state variable" id="_cd30fe90-44e7-497a-9a07-fd4667f6a8cf"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="12350.992" y="1730.5625"/> </glyph> </glyph> <glyph class="simple chemical" id="wca1_wca1_s1672_wca1_wca1_sa707"> <label text="PtdIns(4,5)-P2"/> <bbox w="70.0" h="25.0" x="12464.0" y="1730.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1673_wca1_wca1_sa708"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="12456.0" y="1759.25"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1712_wca1_wca1_csa7" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:APC:AXIN*:CK1_alpha_*:GSK3*:PtdIns:_beta_-Catenin* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17143292 s_wca1_re6:(MAP:survival) PMID:17910481 References_end</body> </html> </notes> <label text="(Destruction_complex)"/> <bbox w="192.0" h="187.0" x="12357.0" y="1863.875"/> <glyph class="macromolecule" id="wca1_wca1_s39_wca1_wca1_sa33"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="12452.0" y="1873.875"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s40_wca1_wca1_sa34"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="12368.0" y="1873.875"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s41_wca1_wca1_sa35"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="12453.5" y="1917.375"/> <glyph class="state variable" id="_14818ee4-0201-4fa1-964c-cb251a9a6624"> <state value="P" variable="S45"/> <bbox w="30.0" h="10.0" x="12478.404" y="1952.375"/> </glyph> <glyph class="state variable" id="_899b75dc-9b97-4373-9a3b-31b1a3c1ec66"> <state value="P" variable="T41"/> <bbox w="30.0" h="10.0" x="12517.882" y="1952.375"/> </glyph> <glyph class="state variable" id="_1b630eba-f04a-4ac8-bfa7-4043ecf13bca"> <state value="P" variable="S37"/> <bbox w="30.0" h="10.0" x="12518.5" y="1912.5897"/> </glyph> <glyph class="state variable" id="_153e86dd-c458-464c-ae4a-f59f07537a54"> <state value="P" variable="S33"/> <bbox w="30.0" h="10.0" x="12478.532" y="1912.375"/> </glyph> <glyph class="state variable" id="_cc2f067f-9261-4caa-a91a-8ec51fd6fa51"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="12441.492" y="1912.375"/> </glyph> <glyph class="state variable" id="_d0a9cb8a-2e5a-47e2-a1a0-ebab4050d7b9"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="12441.0" y="1952.0973"/> </glyph> <glyph class="state variable" id="_8ddcb541-930e-481c-a921-02e710014a44"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="12518.5" y="1912.5897"/> </glyph> <glyph class="state variable" id="_21f1ab73-c382-4916-a183-8160d7e68c29"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="12518.5" y="1912.5897"/> </glyph> <glyph class="state variable" id="_d66bf840-5eec-4e1f-811c-56c106199443"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12448.5" y="1932.375"/> </glyph> <glyph class="state variable" id="_3b13e55c-6793-44eb-a703-1eca85ce84d4"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="12438.992" y="1912.375"/> </glyph> <glyph class="state variable" id="_26b9e5e7-0d91-4c34-891e-cc852dba8946"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="12518.5" y="1912.5897"/> </glyph> <glyph class="state variable" id="_91a3a115-d690-4ef8-9b58-839502d1967a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12448.5" y="1924.0907"/> </glyph> <glyph class="state variable" id="_0ca9b58a-79c5-4972-9459-c15d9e8818f6"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="12518.5" y="1912.5897"/> </glyph> <glyph class="state variable" id="_d73b475a-07b2-46a8-b1c8-20fe87e18904"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12448.5" y="1932.375"/> </glyph> <glyph class="state variable" id="_4e84aab0-859f-4bbe-977a-fd85612fb57e"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="12517.882" y="1952.375"/> </glyph> <glyph class="state variable" id="_e6c18fe6-4001-40b6-b75a-9aac85f9b47c"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="12518.5" y="1912.5897"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s99_wca1_wca1_sa79"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="12368.0" y="1917.0"/> <glyph class="state variable" id="_1b51a832-ec0d-4a0e-b297-65f80cabab17"> <state value="P" variable="S80"/> <bbox w="30.0" h="10.0" x="12353.492" y="1912.0"/> </glyph> <glyph class="state variable" id="_66e4acf5-b493-432a-a7a3-04c1196c9aed"> <state value="P" variable="S82"/> <bbox w="30.0" h="10.0" x="12393.032" y="1912.0"/> </glyph> <glyph class="state variable" id="_a185006c-6124-4794-a340-e98899f5a39c"> <state value="P" variable="S222"/> <bbox w="35.0" h="10.0" x="12430.5" y="1912.2147"/> </glyph> <glyph class="state variable" id="_568f328d-3679-4b13-b6e8-512521369697"> <state value="P" variable="S473"/> <bbox w="35.0" h="10.0" x="12429.882" y="1952.0"/> </glyph> <glyph class="state variable" id="_136bf5cd-ec45-4df5-89ad-c0bf6edbb52e"> <state value="P" variable="S614"/> <bbox w="35.0" h="10.0" x="12390.404" y="1952.0"/> </glyph> <glyph class="state variable" id="_48e77569-6ac1-4074-add7-f3ab2b9e7b2c"> <state value="P" variable="S621"/> <bbox w="35.0" h="10.0" x="12350.5" y="1951.7223"/> </glyph> <glyph class="state variable" id="_7319df28-f6e9-42b9-999b-ff997c339037"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="12395.404" y="1952.0"/> </glyph> <glyph class="state variable" id="_6ab20835-902e-44d4-8298-6af933bcc8d3"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="12434.882" y="1952.0"/> </glyph> <glyph class="state variable" id="_d0222253-930a-4208-b61d-e0ba1ae681fa"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12440.5" y="1912.2147"/> </glyph> <glyph class="state variable" id="_c69a2a9e-d7a3-4538-880b-604011a62edc"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12355.5" y="1951.7223"/> </glyph> <glyph class="state variable" id="_4f343fbb-9d6e-4f7f-b709-0c5fec6fe66f"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12360.992" y="1912.0"/> </glyph> <glyph class="state variable" id="_d04224d2-afa9-4d93-b02e-1ad6f65138b3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12363.0" y="1912.0"/> </glyph> <glyph class="state variable" id="_05f87900-c6e8-4ea5-b844-982ca4dab99c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12443.0" y="1912.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s42_wca1_wca1_sa32"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="12368.0" y="1961.875"/> <glyph class="state variable" id="_3a040deb-4abd-4aec-ac10-0f9b601646a6"> <state value="P" variable="S1505"/> <bbox w="40.0" h="10.0" x="12427.382" y="1996.875"/> </glyph> <glyph class="state variable" id="_790c2647-faad-494c-b50c-083b397bdbb0"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="12350.992" y="1956.875"/> </glyph> <glyph class="state variable" id="_e3989374-770a-48c9-9237-38ceca8d566e"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="12430.5" y="1957.0897"/> </glyph> <glyph class="state variable" id="_b3f8ec65-c026-4efc-bc75-18157d8b0aa8"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="12390.404" y="1996.875"/> </glyph> <glyph class="state variable" id="_421e54ab-8768-44d5-a80c-e2f8efb1fd37"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="12390.532" y="1956.875"/> </glyph> <glyph class="state variable" id="_fd3834e4-f287-42a9-a305-6ee91bcbafe0"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="12350.5" y="1996.5973"/> </glyph> <glyph class="state variable" id="_586268c4-111c-4380-8fcc-43d45d6a1fd7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12443.0" y="1956.875"/> </glyph> <glyph class="state variable" id="_0787cc19-1dda-4023-ad05-9f5fa1b7d5e3"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="12430.5" y="1996.0056"/> </glyph> <glyph class="state variable" id="_9166e3af-d64b-46a7-9bd3-914b82ba43d1"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="12350.5" y="1996.5973"/> </glyph> <glyph class="state variable" id="_878d5d7d-b2b2-4492-a2e9-248c34afd78e"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12355.992" y="1956.875"/> </glyph> <glyph class="state variable" id="_695bb415-c390-44a4-bc67-5fe0115a7bf4"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="12350.992" y="1956.875"/> </glyph> </glyph> <glyph class="simple chemical" id="wca1_wca1_s1674_wca1_wca1_sa709"> <label text="PtdIns(4,5)-P2"/> <bbox w="70.0" h="25.0" x="12459.0" y="1959.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1675_wca1_wca1_sa710"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="12451.0" y="1988.25"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1713_wca1_wca1_csa8" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:APC:AXIN*:CK1_alpha_*:GSK3*:PtdIns:_beta_-Catenin* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17143292 s_wca1_re7:(MAP:survival) PMID:17910481 References_end</body> </html> </notes> <label text="(Destruction_complex)"/> <bbox w="190.0" h="187.0" x="12357.0" y="2090.1875"/> <glyph class="macromolecule" id="wca1_wca1_s45_wca1_wca1_sa37"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="12452.0" y="2100.1875"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s46_wca1_wca1_sa38"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="12368.0" y="2100.1875"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s47_wca1_wca1_sa39"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="12453.5" y="2143.6875"/> <glyph class="state variable" id="_4297d947-d21f-4b48-b7ad-36449569046a"> <state value="P" variable="S45"/> <bbox w="30.0" h="10.0" x="12478.404" y="2178.6875"/> </glyph> <glyph class="state variable" id="_64935f17-67ea-4dc6-9bf9-cc314f91f115"> <state value="P" variable="T41"/> <bbox w="30.0" h="10.0" x="12517.882" y="2178.6875"/> </glyph> <glyph class="state variable" id="_8f16f8ac-b759-4b0e-bc0c-d3088d91a820"> <state value="P" variable="S37"/> <bbox w="30.0" h="10.0" x="12518.5" y="2138.9023"/> </glyph> <glyph class="state variable" id="_d9e19c4e-ae9c-4cc0-a279-93cbee3eb190"> <state value="P" variable="S33"/> <bbox w="30.0" h="10.0" x="12478.532" y="2138.6875"/> </glyph> <glyph class="state variable" id="_31c09ae5-fa3d-4739-a8c9-c204583f951b"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="12441.492" y="2138.6875"/> </glyph> <glyph class="state variable" id="_b113c8fc-f823-43d1-9cef-1a8d8026b6c2"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="12441.0" y="2178.41"/> </glyph> <glyph class="state variable" id="_9dd1789a-3302-409c-933b-50631a2c6cd5"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="12518.5" y="2138.9023"/> </glyph> <glyph class="state variable" id="_068ffaab-ddde-4abb-8de5-5f09ca252000"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="12518.5" y="2138.9023"/> </glyph> <glyph class="state variable" id="_6de479ac-e712-4550-b94b-b41c1fe9960d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12448.5" y="2158.6875"/> </glyph> <glyph class="state variable" id="_2c1ca3a2-ff60-4a75-a1ae-545b346e19cc"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="12438.992" y="2138.6875"/> </glyph> <glyph class="state variable" id="_89d0666d-adf3-4f69-9881-c69188a8b7b9"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="12518.5" y="2138.9023"/> </glyph> <glyph class="state variable" id="_afe19f0d-04ab-4ccf-bb89-c2b4c74d404d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12448.5" y="2150.4033"/> </glyph> <glyph class="state variable" id="_058b48a1-c285-41c6-82df-87e6892cd538"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="12518.5" y="2138.9023"/> </glyph> <glyph class="state variable" id="_2df59f06-6c66-4274-9d88-203793bce8dd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12448.5" y="2158.6875"/> </glyph> <glyph class="state variable" id="_f434afb1-8a1e-4f29-b076-765b5649eb77"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="12517.882" y="2178.6875"/> </glyph> <glyph class="state variable" id="_35ebec2c-fce2-4f1a-9f70-59549b9d2674"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="12518.5" y="2138.9023"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s100_wca1_wca1_sa80"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="12367.0" y="2144.0"/> <glyph class="state variable" id="_acc6dc13-0300-4cdd-9c43-0be185485d4c"> <state value="P" variable="S80"/> <bbox w="30.0" h="10.0" x="12352.492" y="2139.0"/> </glyph> <glyph class="state variable" id="_fb91ad92-be91-4a0f-a89f-79d59f63ccfa"> <state value="P" variable="S82"/> <bbox w="30.0" h="10.0" x="12392.032" y="2139.0"/> </glyph> <glyph class="state variable" id="_6121476c-8184-48ca-9cae-d54a5eba0af9"> <state value="P" variable="S222"/> <bbox w="35.0" h="10.0" x="12429.5" y="2139.2148"/> </glyph> <glyph class="state variable" id="_eeee9b1a-a386-4c1c-bfd2-ef5f3f14c451"> <state value="P" variable="S473"/> <bbox w="35.0" h="10.0" x="12428.882" y="2179.0"/> </glyph> <glyph class="state variable" id="_53e44040-efcb-41b0-a690-32fe897ce7a8"> <state value="P" variable="S614"/> <bbox w="35.0" h="10.0" x="12389.404" y="2179.0"/> </glyph> <glyph class="state variable" id="_d31af2e0-9dcd-44c5-8dc7-b201ef11e59a"> <state value="P" variable="S621"/> <bbox w="35.0" h="10.0" x="12349.5" y="2178.7224"/> </glyph> <glyph class="state variable" id="_c264c928-fa64-4fab-a2eb-d309c0e6d5e1"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="12394.404" y="2179.0"/> </glyph> <glyph class="state variable" id="_15f47df9-8dcf-43f6-9eb7-4cd726176875"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="12433.882" y="2179.0"/> </glyph> <glyph class="state variable" id="_b4a53d27-611a-4465-8108-ee58a8f4cb6e"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12439.5" y="2139.2148"/> </glyph> <glyph class="state variable" id="_483b3125-8013-49b3-a827-c6fe08a1cd73"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12354.5" y="2178.7224"/> </glyph> <glyph class="state variable" id="_0c79cf40-e6b9-4cc7-b1aa-b6ba1cde169c"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12359.992" y="2139.0"/> </glyph> <glyph class="state variable" id="_287e2e21-cf84-4d20-a9f5-6350c8f978d8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12362.0" y="2139.0"/> </glyph> <glyph class="state variable" id="_695cb3e8-9788-458a-8691-0c5fd66911c5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12442.0" y="2139.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s48_wca1_wca1_sa40"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="12368.0" y="2188.1875"/> <glyph class="state variable" id="_b28678a8-c6e2-4d0c-adb3-6cefa074142b"> <state value="P" variable="S1505"/> <bbox w="40.0" h="10.0" x="12427.382" y="2223.1875"/> </glyph> <glyph class="state variable" id="_6fd65060-da0c-4f49-be39-5067ee370183"> <state value="P" variable="S1501"/> <bbox w="40.0" h="10.0" x="12348.492" y="2183.1875"/> </glyph> <glyph class="state variable" id="_a3a88b01-719d-4436-8a58-697f0cec8e90"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="12430.5" y="2183.4023"/> </glyph> <glyph class="state variable" id="_a6a8ec9f-653d-46fe-bcb8-432eb51a858d"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="12390.404" y="2223.1875"/> </glyph> <glyph class="state variable" id="_ea9bc6e6-7cf7-4f86-8034-917af74cba4f"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="12390.532" y="2183.1875"/> </glyph> <glyph class="state variable" id="_a12b0468-d992-4f98-8e82-adeb72ee6a08"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="12350.5" y="2222.91"/> </glyph> <glyph class="state variable" id="_05dcf7c9-1498-4f72-b79b-10bf0636b6ae"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12443.0" y="2183.1875"/> </glyph> <glyph class="state variable" id="_431ded8a-a387-47d2-9c63-1a70ac05aaad"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="12430.5" y="2222.318"/> </glyph> <glyph class="state variable" id="_013897ba-71b7-4bd4-93d6-a2a782288a70"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="12350.5" y="2222.91"/> </glyph> <glyph class="state variable" id="_89a9ac7f-d1cb-4a5d-9013-ffe7ff982af3"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12355.992" y="2183.1875"/> </glyph> <glyph class="state variable" id="_864d9cb1-0fa8-4e09-bb16-1d4e37519c6b"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="12350.992" y="2183.1875"/> </glyph> </glyph> <glyph class="simple chemical" id="wca1_wca1_s1676_wca1_wca1_sa711"> <label text="PtdIns(4,5)-P2"/> <bbox w="70.0" h="25.0" x="12460.0" y="2186.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1677_wca1_wca1_sa712"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="12452.0" y="2215.25"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1714_wca1_wca1_csa9" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:APC:AXIN*:CK1_alpha_*:GSK3*:PtdIns:_beta_-Catenin* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17143292 s_wca1_re8:(MAP:survival) PMID:17910481 References_end</body> </html> </notes> <label text="(Destruction_complex)"/> <bbox w="192.0" h="185.0" x="12357.0" y="2316.5"/> <glyph class="macromolecule" id="wca1_wca1_s51_wca1_wca1_sa42"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="12452.0" y="2326.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s52_wca1_wca1_sa43"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="12368.0" y="2326.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s53_wca1_wca1_sa44"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="12453.5" y="2370.0"/> <glyph class="state variable" id="_7dc9dcc5-ab11-4d40-8c13-402a8e50a244"> <state value="P" variable="S45"/> <bbox w="30.0" h="10.0" x="12478.404" y="2405.0"/> </glyph> <glyph class="state variable" id="_9956c2b7-d3eb-4915-beeb-2a3904d144d1"> <state value="P" variable="T41"/> <bbox w="30.0" h="10.0" x="12517.882" y="2405.0"/> </glyph> <glyph class="state variable" id="_7ca021b2-bc1d-44f4-87dd-868c4b6f6e1c"> <state value="P" variable="S37"/> <bbox w="30.0" h="10.0" x="12518.5" y="2365.2148"/> </glyph> <glyph class="state variable" id="_a6e838b2-b311-4e55-ac05-03f65a8f931f"> <state value="P" variable="S33"/> <bbox w="30.0" h="10.0" x="12478.532" y="2365.0"/> </glyph> <glyph class="state variable" id="_7d58a4cd-6e81-4b32-9650-770660f2ad3d"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="12441.492" y="2365.0"/> </glyph> <glyph class="state variable" id="_0083f52b-b666-4b37-90da-eaf6d051044e"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="12441.0" y="2404.7224"/> </glyph> <glyph class="state variable" id="_94846b8e-be35-470f-a071-32745462c393"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="12518.5" y="2365.2148"/> </glyph> <glyph class="state variable" id="_feb71681-903f-43a2-b95c-2bec0fcb540c"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="12518.5" y="2365.2148"/> </glyph> <glyph class="state variable" id="_ad7940e5-420f-4825-8983-69ea488c1420"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12448.5" y="2385.0"/> </glyph> <glyph class="state variable" id="_528c7482-22a6-43fc-a10d-5b893dd25dd0"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="12438.992" y="2365.0"/> </glyph> <glyph class="state variable" id="_779ba851-349b-40ae-95cb-ec718e81d69e"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="12518.5" y="2365.2148"/> </glyph> <glyph class="state variable" id="_cb57aedb-8cb4-4512-b697-b6b1a1eddb5c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12448.5" y="2376.7158"/> </glyph> <glyph class="state variable" id="_37a7cc5b-2ca5-4f76-bec9-1fee1874595b"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="12518.5" y="2365.2148"/> </glyph> <glyph class="state variable" id="_24db21b8-2b83-49b8-8649-10e2725e00cf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12448.5" y="2385.0"/> </glyph> <glyph class="state variable" id="_442e4f97-196e-4216-8038-a6b3a680b057"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="12517.882" y="2405.0"/> </glyph> <glyph class="state variable" id="_9626d101-620f-4528-82d6-51f933b53534"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="12518.5" y="2365.2148"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s101_wca1_wca1_sa81"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="12369.0" y="2372.0"/> <glyph class="state variable" id="_317a6dc2-89e8-45bd-8d89-543b9ea40f2e"> <state value="P" variable="S80"/> <bbox w="30.0" h="10.0" x="12354.492" y="2367.0"/> </glyph> <glyph class="state variable" id="_a32bbf3b-10e5-479c-90cf-bf2197bc56fd"> <state value="P" variable="S82"/> <bbox w="30.0" h="10.0" x="12394.032" y="2367.0"/> </glyph> <glyph class="state variable" id="_f4ef0b9e-2ff6-42f8-a903-695047b084c0"> <state value="P" variable="S222"/> <bbox w="35.0" h="10.0" x="12431.5" y="2367.2148"/> </glyph> <glyph class="state variable" id="_df9adc67-d5c7-4f20-a3f2-a238d02d8c41"> <state value="P" variable="S473"/> <bbox w="35.0" h="10.0" x="12430.882" y="2407.0"/> </glyph> <glyph class="state variable" id="_4bda3239-52f8-4a3b-a8c0-3275b03ec3e0"> <state value="P" variable="S614"/> <bbox w="35.0" h="10.0" x="12391.404" y="2407.0"/> </glyph> <glyph class="state variable" id="_4ecba86e-dfac-4de9-bebb-f59a8736acd7"> <state value="P" variable="S621"/> <bbox w="35.0" h="10.0" x="12351.5" y="2406.7224"/> </glyph> <glyph class="state variable" id="_3b18b41d-8192-4f17-b791-bb0435547651"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="12396.404" y="2407.0"/> </glyph> <glyph class="state variable" id="_f0c427d2-e845-4a76-a853-41fce908fd7d"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="12435.882" y="2407.0"/> </glyph> <glyph class="state variable" id="_167530bf-5823-4db1-9153-8c34e300f506"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12441.5" y="2367.2148"/> </glyph> <glyph class="state variable" id="_b8f48e60-98c8-482a-8acf-98da824bb7cf"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12356.5" y="2406.7224"/> </glyph> <glyph class="state variable" id="_ecbda2a8-23cd-460c-8551-01763740d2ff"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12361.992" y="2367.0"/> </glyph> <glyph class="state variable" id="_f8ef2f46-f779-4ba5-96cc-faf67cf9bb7e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12364.0" y="2367.0"/> </glyph> <glyph class="state variable" id="_ac17841f-713e-42ec-ba0c-3ebc53a697f0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12444.0" y="2367.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s54_wca1_wca1_sa45"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="12368.0" y="2414.5"/> <glyph class="state variable" id="_de941626-a736-43ef-84c8-0429ad2c1eb5"> <state value="P" variable="S1505"/> <bbox w="40.0" h="10.0" x="12427.382" y="2449.5"/> </glyph> <glyph class="state variable" id="_86509627-6848-40dd-9528-a0d50f4b1fce"> <state value="P" variable="S1501"/> <bbox w="40.0" h="10.0" x="12348.492" y="2409.5"/> </glyph> <glyph class="state variable" id="_bf6831fc-3e34-45b7-b3d2-dd5ec88b06cd"> <state value="P" variable="S1504"/> <bbox w="40.0" h="10.0" x="12428.0" y="2409.7148"/> </glyph> <glyph class="state variable" id="_b9081ccb-bded-4f89-992e-683b0f046a4d"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="12390.404" y="2449.5"/> </glyph> <glyph class="state variable" id="_ec42a058-7649-4e29-8955-ea8342f5ddf3"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="12390.532" y="2409.5"/> </glyph> <glyph class="state variable" id="_94d29476-b13b-424a-a320-c392ed352e1c"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="12350.5" y="2449.2224"/> </glyph> <glyph class="state variable" id="_89d3d61e-d4e7-42b6-b5a6-730b04680a66"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12443.0" y="2409.5"/> </glyph> <glyph class="state variable" id="_593f04ff-78b2-4ea8-ad69-f62c3272495d"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="12430.5" y="2448.6306"/> </glyph> <glyph class="state variable" id="_25f2fd59-c845-46e2-9ddf-6e1cd7034217"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="12350.5" y="2449.2224"/> </glyph> <glyph class="state variable" id="_9965197d-0912-4f43-8622-58eb9325dd31"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12355.992" y="2409.5"/> </glyph> <glyph class="state variable" id="_4073e0cc-0411-4ae4-a4bd-2e6f07c904a7"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="12350.992" y="2409.5"/> </glyph> </glyph> <glyph class="simple chemical" id="wca1_wca1_s1678_wca1_wca1_sa713"> <label text="PtdIns(4,5)-P2"/> <bbox w="70.0" h="25.0" x="12465.0" y="2412.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1679_wca1_wca1_sa714"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="12457.0" y="2441.25"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1715_wca1_wca1_csa10" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:APC:AXIN*:CK1_alpha_*:GSK3*:PtdIns:_beta_-Catenin* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17143292 s_wca1_re9:(MAP:survival) PMID:17910481 References_end</body> </html> </notes> <label text="(Destruction_complex)"/> <bbox w="194.0" h="187.0" x="12749.833" y="2315.5"/> <glyph class="macromolecule" id="wca1_wca1_s57_wca1_wca1_sa47"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="12844.833" y="2325.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s58_wca1_wca1_sa48"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="12760.833" y="2325.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s59_wca1_wca1_sa49"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="12846.333" y="2369.0"/> <glyph class="state variable" id="_137af995-965c-47d7-8496-4fe63079bc83"> <state value="P" variable="S45"/> <bbox w="30.0" h="10.0" x="12871.237" y="2404.0"/> </glyph> <glyph class="state variable" id="_bc22dbd3-9848-42e4-8281-0239ab143c10"> <state value="P" variable="T41"/> <bbox w="30.0" h="10.0" x="12910.715" y="2404.0"/> </glyph> <glyph class="state variable" id="_3f5b682d-d151-4759-a7e0-dc6d8bfc4d52"> <state value="P" variable="S37"/> <bbox w="30.0" h="10.0" x="12911.333" y="2364.2148"/> </glyph> <glyph class="state variable" id="_02d2d3b4-81aa-4d74-a073-a9fd44a77113"> <state value="P" variable="S33"/> <bbox w="30.0" h="10.0" x="12871.365" y="2364.0"/> </glyph> <glyph class="state variable" id="_f63ef240-5cb2-469a-9312-341a4bba2579"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="12834.325" y="2364.0"/> </glyph> <glyph class="state variable" id="_2932e48b-6a87-4f61-988d-0c5793b36395"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="12833.833" y="2403.7224"/> </glyph> <glyph class="state variable" id="_f6ea00a7-f36c-4c38-90a8-a298a219cbed"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="12911.333" y="2364.2148"/> </glyph> <glyph class="state variable" id="_955b30f1-b8ad-4c9e-894b-7bed9fb267ab"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="12911.333" y="2364.2148"/> </glyph> <glyph class="state variable" id="_4e3a8a73-0321-488b-9079-eb1256f1d858"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12841.333" y="2384.0"/> </glyph> <glyph class="state variable" id="_d38171f6-7e13-4f75-96ca-0f662ab35ed8"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="12831.825" y="2364.0"/> </glyph> <glyph class="state variable" id="_0d2d91f3-3834-4716-bf64-0b8b57be7905"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="12911.333" y="2364.2148"/> </glyph> <glyph class="state variable" id="_9d393830-b0ac-437d-8332-4ff6ecc1be42"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12841.333" y="2375.7158"/> </glyph> <glyph class="state variable" id="_6760c268-7290-43e6-8b06-f821729be963"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="12911.333" y="2364.2148"/> </glyph> <glyph class="state variable" id="_9d91ebd7-7f2a-4807-846f-7ab8ee5189f6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12841.333" y="2384.0"/> </glyph> <glyph class="state variable" id="_0fb079fc-0f2b-4f49-b529-038cf6cd7df7"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="12910.715" y="2404.0"/> </glyph> <glyph class="state variable" id="_bd89dfa7-e7ba-4a90-bbd0-b1baeb688a68"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="12911.333" y="2364.2148"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s102_wca1_wca1_sa82"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="12759.583" y="2370.0"/> <glyph class="state variable" id="_8cf15aa5-3a64-48c4-beef-9e57c9d7f19d"> <state value="P" variable="S80"/> <bbox w="30.0" h="10.0" x="12745.075" y="2365.0"/> </glyph> <glyph class="state variable" id="_722e260a-0d56-485c-925f-cf9296b4922d"> <state value="P" variable="S82"/> <bbox w="30.0" h="10.0" x="12784.615" y="2365.0"/> </glyph> <glyph class="state variable" id="_d9e9b2cf-bb88-422c-8137-74774b427423"> <state value="P" variable="S222"/> <bbox w="35.0" h="10.0" x="12822.083" y="2365.2148"/> </glyph> <glyph class="state variable" id="_68bfb466-1b4a-459f-8228-9569fe7e9cc2"> <state value="P" variable="S473"/> <bbox w="35.0" h="10.0" x="12821.465" y="2405.0"/> </glyph> <glyph class="state variable" id="_1f59768e-8f37-4c01-bc60-6b83a0109b85"> <state value="P" variable="S614"/> <bbox w="35.0" h="10.0" x="12781.987" y="2405.0"/> </glyph> <glyph class="state variable" id="_684753cc-c7b1-448f-85a0-5dcd8c899b8b"> <state value="P" variable="S621"/> <bbox w="35.0" h="10.0" x="12742.083" y="2404.7224"/> </glyph> <glyph class="state variable" id="_fce2432f-b8ce-4699-9501-66e812108a7c"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="12786.987" y="2405.0"/> </glyph> <glyph class="state variable" id="_82b3fd34-6c01-495c-8dff-226be5e07858"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="12826.465" y="2405.0"/> </glyph> <glyph class="state variable" id="_750c3aa8-f414-4249-bedd-e83922fbdf77"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12832.083" y="2365.2148"/> </glyph> <glyph class="state variable" id="_48085b5d-da29-455e-a1a8-25ffd07f9ffb"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12747.083" y="2404.7224"/> </glyph> <glyph class="state variable" id="_747f518b-ba81-417c-ac80-3bb2465fa0d6"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12752.575" y="2365.0"/> </glyph> <glyph class="state variable" id="_602a37c7-63b3-4e0f-bef1-395531f89ebd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12754.583" y="2365.0"/> </glyph> <glyph class="state variable" id="_03d41425-ac98-4025-9bf0-49d7bebf8633"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12834.583" y="2365.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s60_wca1_wca1_sa50"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="12760.833" y="2413.5"/> <glyph class="state variable" id="_e012acb2-c138-4260-9f93-00754861d379"> <state value="P" variable="S1505"/> <bbox w="40.0" h="10.0" x="12820.215" y="2448.5"/> </glyph> <glyph class="state variable" id="_974a8e03-516b-4c2b-a9cc-525734821532"> <state value="P" variable="S1501"/> <bbox w="40.0" h="10.0" x="12741.325" y="2408.5"/> </glyph> <glyph class="state variable" id="_d4d40de0-a61b-4d9c-8bd5-b6b16b8e0d50"> <state value="P" variable="S1504"/> <bbox w="40.0" h="10.0" x="12820.833" y="2408.7148"/> </glyph> <glyph class="state variable" id="_6af99818-c5a7-45da-8d64-0c8d43190e55"> <state value="P" variable="S1507"/> <bbox w="40.0" h="10.0" x="12780.737" y="2448.5"/> </glyph> <glyph class="state variable" id="_278395da-0bd0-4d15-96ef-317e26ddf2a8"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="12783.365" y="2408.5"/> </glyph> <glyph class="state variable" id="_597a5e9c-8f8e-41b8-89e8-568e6783819e"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="12743.333" y="2448.2224"/> </glyph> <glyph class="state variable" id="_b322cacb-bf96-4e73-ab15-46cf7f792171"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12835.833" y="2408.5"/> </glyph> <glyph class="state variable" id="_e653c032-20d0-4dd6-8572-d56cd20701a3"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="12823.333" y="2447.6306"/> </glyph> <glyph class="state variable" id="_92955f94-553d-4fc1-987a-b22ec8327581"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="12743.333" y="2448.2224"/> </glyph> <glyph class="state variable" id="_93165f1e-86df-4f3a-a077-763f48ce7fbb"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12748.825" y="2408.5"/> </glyph> <glyph class="state variable" id="_283ad26e-faa0-4088-b3b1-a87572a8ca52"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="12743.825" y="2408.5"/> </glyph> </glyph> <glyph class="simple chemical" id="wca1_wca1_s1680_wca1_wca1_sa715"> <label text="PtdIns(4,5)-P2"/> <bbox w="70.0" h="25.0" x="12861.0" y="2413.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1681_wca1_wca1_sa716"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="12853.0" y="2442.25"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1716_wca1_wca1_csa11" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:APC:AXIN*:CK1_alpha_*:GSK3*:PtdIns:_beta_-Catenin* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17143292 s_wca1_re10:(MAP:survival) PMID:17910481 s_wca1_re47(MAP:survival): PMID:19576224 PMID:17143292 PMID:10023660 PMID:21411632 PMID:22730322 PMID:22682247 FAF1 enhances poly-ubiquitination of beta-catenin by acting as scaffold protein Intact destruction complex in the proteosome complex References_end</body> </html> </notes> <label text="(Destruction_complex)"/> <bbox w="190.0" h="195.0" x="13037.667" y="2311.5"/> <glyph class="macromolecule" id="wca1_wca1_s82_wca1_wca1_sa52"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="13132.667" y="2321.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s81_wca1_wca1_sa53"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="13048.667" y="2321.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s36_wca1_wca1_sa54"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="13133.167" y="2368.0"/> <glyph class="state variable" id="_f3835a63-114f-45b5-916f-c472b18cd1fc"> <state value="P" variable="S45"/> <bbox w="30.0" h="10.0" x="13158.071" y="2403.0"/> </glyph> <glyph class="state variable" id="_e284a1a1-68c8-4a9c-9015-61e981628f85"> <state value="P" variable="T41"/> <bbox w="30.0" h="10.0" x="13197.549" y="2403.0"/> </glyph> <glyph class="state variable" id="_6d228a04-5ddc-43c9-a429-fbcdceefdc95"> <state value="P" variable="S37"/> <bbox w="30.0" h="10.0" x="13198.167" y="2363.2148"/> </glyph> <glyph class="state variable" id="_03319f28-4dff-4743-9d99-ee4a183e0bcb"> <state value="P" variable="S33"/> <bbox w="30.0" h="10.0" x="13158.199" y="2363.0"/> </glyph> <glyph class="state variable" id="_9ff8f722-37a4-4829-86de-0fa9bad247fe"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="13121.159" y="2363.0"/> </glyph> <glyph class="state variable" id="_ac54d874-f58f-46d9-a191-04a2aaab66bc"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="13120.667" y="2402.7224"/> </glyph> <glyph class="state variable" id="_63ec4510-3d35-45c3-a49d-a71f783c7e0e"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="13198.167" y="2363.2148"/> </glyph> <glyph class="state variable" id="_ce6d76ae-f6e0-4dab-bbe2-593f6014864a"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="13198.167" y="2363.2148"/> </glyph> <glyph class="state variable" id="_e21fa6c7-a029-4e7e-9966-5126b8a854f7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13128.167" y="2383.0"/> </glyph> <glyph class="state variable" id="_c7f51c4e-f7b4-4dca-9fc8-e81947496fd5"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="13118.659" y="2363.0"/> </glyph> <glyph class="state variable" id="_6c9c8fde-9c55-4480-961f-3261931161ef"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="13198.167" y="2363.2148"/> </glyph> <glyph class="state variable" id="_db36bf38-587f-46ad-8336-2dab84743c20"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13128.167" y="2374.7158"/> </glyph> <glyph class="state variable" id="_992d906d-bf69-4c82-8586-139285a07807"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="13198.167" y="2363.2148"/> </glyph> <glyph class="state variable" id="_c6983272-4a36-4dfd-812f-446a1cd3da46"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13128.167" y="2383.0"/> </glyph> <glyph class="state variable" id="_42597754-b6bd-4efb-8e86-45b0ea3f82e2"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="13197.549" y="2403.0"/> </glyph> <glyph class="state variable" id="_e2d1414a-04e8-4654-8b4a-ad414584f197"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="13198.167" y="2363.2148"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s83_wca1_wca1_sa83"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="13047.667" y="2366.0"/> <glyph class="state variable" id="_4ef5395f-3fdf-42dd-81ed-f8d0e8db3af5"> <state value="P" variable="S80"/> <bbox w="30.0" h="10.0" x="13033.159" y="2361.0"/> </glyph> <glyph class="state variable" id="_c1777dce-8258-40f1-8fa4-5d8040e2f66a"> <state value="P" variable="S82"/> <bbox w="30.0" h="10.0" x="13072.699" y="2361.0"/> </glyph> <glyph class="state variable" id="_912b0fc1-0770-4fb4-b751-e66d0bd54712"> <state value="P" variable="S222"/> <bbox w="35.0" h="10.0" x="13110.167" y="2361.2148"/> </glyph> <glyph class="state variable" id="_20ab361b-3493-47e7-8257-09ee3fe0065b"> <state value="P" variable="S473"/> <bbox w="35.0" h="10.0" x="13109.549" y="2401.0"/> </glyph> <glyph class="state variable" id="_9656b2e6-f34c-4308-be70-5727eeed9620"> <state value="P" variable="S614"/> <bbox w="35.0" h="10.0" x="13070.071" y="2401.0"/> </glyph> <glyph class="state variable" id="_510fc6ed-fce0-4dfd-b833-80aa223c0e7f"> <state value="P" variable="S621"/> <bbox w="35.0" h="10.0" x="13030.167" y="2400.7224"/> </glyph> <glyph class="state variable" id="_223ce017-d4e0-48dd-88e7-e42c5ff08ab5"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="13075.071" y="2401.0"/> </glyph> <glyph class="state variable" id="_478274dd-e127-45eb-9f9d-2f92a99e81d5"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="13114.549" y="2401.0"/> </glyph> <glyph class="state variable" id="_5e32f2da-6cba-4ca8-9cec-763862d881d1"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="13120.167" y="2361.2148"/> </glyph> <glyph class="state variable" id="_56f32a90-265f-41bc-819c-e6063eb7f506"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13035.167" y="2400.7224"/> </glyph> <glyph class="state variable" id="_844026d5-8c2a-4bda-9aea-e813afbbeaef"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="13040.659" y="2361.0"/> </glyph> <glyph class="state variable" id="_35a8a99f-045b-4cb9-849c-92db5bb70227"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13042.667" y="2361.0"/> </glyph> <glyph class="state variable" id="_c3d7fd16-9348-41f0-8c0c-84d46d040abe"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13122.667" y="2361.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s66_wca1_wca1_sa55"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="13048.667" y="2409.5"/> <glyph class="state variable" id="_5a857e80-7ca9-4f47-ba50-173904f606ef"> <state value="P" variable="S1505"/> <bbox w="40.0" h="10.0" x="13108.049" y="2444.5"/> </glyph> <glyph class="state variable" id="_4710f162-aacf-42a1-865f-c94d688373e6"> <state value="P" variable="S1501"/> <bbox w="40.0" h="10.0" x="13029.159" y="2404.5"/> </glyph> <glyph class="state variable" id="_f0b69524-5fbc-4aed-ab01-3423d9456fd5"> <state value="P" variable="S1504"/> <bbox w="40.0" h="10.0" x="13108.667" y="2404.7148"/> </glyph> <glyph class="state variable" id="_52e46a9c-f217-4af4-8377-cbdf71b17f95"> <state value="P" variable="S1507"/> <bbox w="40.0" h="10.0" x="13068.571" y="2444.5"/> </glyph> <glyph class="state variable" id="_96d69439-15b9-4e0e-b4c5-fc6232599746"> <state value="P" variable="S1503"/> <bbox w="40.0" h="10.0" x="13068.699" y="2404.5"/> </glyph> <glyph class="state variable" id="_7476c76b-0453-454c-9734-5abc1c06ec2c"> <state value="P" variable="S1510"/> <bbox w="40.0" h="10.0" x="13028.667" y="2444.2224"/> </glyph> <glyph class="state variable" id="_0a5a5a48-9cba-47a8-81c3-e9eb7053ead8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13123.667" y="2404.5"/> </glyph> <glyph class="state variable" id="_28440a73-50f0-469a-b182-b4603b1d1272"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="13111.167" y="2443.6306"/> </glyph> <glyph class="state variable" id="_e977fd5f-4354-40b2-830d-c50a1316e3fc"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="13031.167" y="2444.2224"/> </glyph> <glyph class="state variable" id="_c7b4e771-b2cc-47f6-b172-5ec2aeff009f"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13036.659" y="2404.5"/> </glyph> <glyph class="state variable" id="_d2bee8bc-ba6b-4cbd-bf4e-d4b963121683"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="13031.659" y="2404.5"/> </glyph> </glyph> <glyph class="simple chemical" id="wca1_wca1_s1682_wca1_wca1_sa717"> <label text="PtdIns(4,5)-P2"/> <bbox w="70.0" h="25.0" x="13143.0" y="2415.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1683_wca1_wca1_sa718"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="13135.0" y="2444.25"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1717_wca1_wca1_csa22" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CUL1:RBX1:SKP*:_beta_TRCP* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:10023660 s_wca1_re46(MAP:survival): PMID:15688063 PMID:22730322 FAF1 acts as scaffold protein References_end</body> </html> </notes> <label text="(E3_ligase_complex)"/> <bbox w="177.0" h="114.0" x="12749.0" y="1989.0"/> <glyph class="macromolecule" id="wca1_wca1_s157_wca1_wca1_sa126"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> </notes> <label text="CUL1"/> <bbox w="80.0" h="40.0" x="12757.0" y="2000.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s158_wca1_wca1_sa127"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> </notes> <label text="RBX1"/> <bbox w="80.0" h="40.0" x="12756.0" y="2043.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s159_wca1_wca1_sa128"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 S-phase kinase-associated protein 2 (p45) HUGO:SKP2 HGNC:10901 ENTREZ:6502 UNIPROT:Q13309 GENECARDS:SKP2 REACTOME:405589 KEGG:6502 ATLASONC:GC_SKP2 WIKI:SKP2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15688063 PMID:15340381 PMID:12820959 References_end</body> </html> </notes> <label text="SKP*"/> <bbox w="80.0" h="40.0" x="12838.0" y="2000.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s160_wca1_wca1_sa129"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Beta-transducin repeat domain HUGO:BTRC HGNC:1144 ENTREZ:8945 UNIPROT:Q9Y297 GENECARDS:BTRC REACTOME:55056 KEGG:8945 ATLASONC:BTRCID451ch10q24 WIKI:BTRC F-box and WD repeat domain containing 11 BTRC2, BTRCP2, Fbw1b, Fbw11, Hos, KIAA0696 HUGO:FBXW11 HGNC:13607 ENTREZ:23291 UNIPROT:Q9UKB1 GENECARDS:FBXW11 REACTOME:55058 KEGG:23291 WIKI:FBXW11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 E3 Ligase subunit References_end Identifiers_begin: Beta-transducin repeat domain HUGO:BTRC HGNC:1144 ENTREZ:8945 UNIPROT:Q9Y297 GENECARDS:BTRC REACTOME:55056 KEGG:8945 ATLASONC:BTRCID451ch10q24 WIKI:BTRC F-box and WD repeat domain containing 11 BTRC2, BTRCP2, Fbw1b, Fbw11, Hos, KIAA0696 HUGO:FBXW11 HGNC:13607 ENTREZ:23291 UNIPROT:Q9UKB1 GENECARDS:FBXW11 REACTOME:55058 KEGG:23291 WIKI:FBXW11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 E3 Ligase subunit References_end</body> </html> Identifiers_begin: Beta-transducin repeat domain HUGO:BTRC HGNC:1144 ENTREZ:8945 UNIPROT:Q9Y297 GENECARDS:BTRC REACTOME:55056 KEGG:8945 ATLASONC:BTRCID451ch10q24 WIKI:BTRC F-box and WD repeat domain containing 11 BTRC2, BTRCP2, Fbw1b, Fbw11, Hos, KIAA0696 HUGO:FBXW11 HGNC:13607 ENTREZ:23291 UNIPROT:Q9UKB1 GENECARDS:FBXW11 REACTOME:55058 KEGG:23291 WIKI:FBXW11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 E3 Ligase subunit References_end</body> </html> </notes> <label text="βTRCP*"/> <bbox w="80.0" h="40.0" x="12838.0" y="2043.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1718_wca1_wca1_csa23" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:APC:AXIN*:CK1_alpha_*:CK2_alpha_:CK2_alpha_*:CK2_beta_*:CSN1*:CSN2*:CSN3*:CSN4*:CSN5*:CSN6*:CSN7*:CSN8*:CUL1:E1*:FAF*:GSK3*:NEDD8:PKD*:PtdIns:RAD6*:RBX1:SKP*:USP15:_beta_-Catenin*:_beta_TRCP* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17143292 s_wca1_re47(MAP:survival): PMID:19576224 PMID:17143292 PMID:10023660 PMID:21411632 PMID:22730322 PMID:22682247 FAF1 enhances poly-ubiquitination of beta-catenin by acting as scaffold protein Intact destruction complex in the proteosome complex References_end</body> </html> </notes> <label text="(CSN_CRL_Destruction_complex)"/> <bbox w="191.0" h="647.0" x="13317.5" y="1876.5"/> <glyph class="macromolecule" id="wca1_wca1_s594_wca1_wca1_sa132"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="13411.5" y="2359.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s595_wca1_wca1_sa133"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="13328.5" y="2317.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s167_wca1_wca1_sa134"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="13328.5" y="2362.0"/> <glyph class="state variable" id="_c94e953d-5d7c-43b4-8527-c400e15a35a4"> <state value="P" variable="S80"/> <bbox w="30.0" h="10.0" x="13313.992" y="2357.0"/> </glyph> <glyph class="state variable" id="_17a3a5fb-41a2-46a5-83a9-28d24224ad25"> <state value="P" variable="S82"/> <bbox w="30.0" h="10.0" x="13353.532" y="2357.0"/> </glyph> <glyph class="state variable" id="_eeb28409-ea2f-4dbe-b7ab-bd821843312e"> <state value="P" variable="S222"/> <bbox w="35.0" h="10.0" x="13391.0" y="2357.2148"/> </glyph> <glyph class="state variable" id="_f04248b6-3862-4078-adfc-0c841da46d39"> <state value="P" variable="S473"/> <bbox w="35.0" h="10.0" x="13390.382" y="2397.0"/> </glyph> <glyph class="state variable" id="_a5c6206b-b625-4bee-a2ad-7e8b7189f307"> <state value="P" variable="S614"/> <bbox w="35.0" h="10.0" x="13350.904" y="2397.0"/> </glyph> <glyph class="state variable" id="_02353452-d021-4570-a948-97970737446b"> <state value="P" variable="S621"/> <bbox w="35.0" h="10.0" x="13311.0" y="2396.7224"/> </glyph> <glyph class="state variable" id="_2e0d0229-efd8-466a-951e-ce816ab1429f"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="13355.904" y="2397.0"/> </glyph> <glyph class="state variable" id="_9c1f1f6f-f0ae-4692-8480-a63e5233a67a"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="13395.382" y="2397.0"/> </glyph> <glyph class="state variable" id="_7396854c-9c29-44e3-b2de-cbd983ba1c06"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="13401.0" y="2357.2148"/> </glyph> <glyph class="state variable" id="_ebd2801c-c1d5-4be0-8908-a02da5211b13"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13316.0" y="2396.7224"/> </glyph> <glyph class="state variable" id="_b892279f-f80a-4ba8-a3f7-8e21d2feb4d2"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="13321.492" y="2357.0"/> </glyph> <glyph class="state variable" id="_1d0d73b9-9725-435a-bd92-bf75dcce50d3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13323.5" y="2357.0"/> </glyph> <glyph class="state variable" id="_91393055-a322-47c4-81f3-288fbd1c2aca"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13403.5" y="2357.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s168_wca1_wca1_sa135"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="13328.5" y="2405.5"/> <glyph class="state variable" id="_09a21074-c1d5-4992-8bbe-1f2fe4166612"> <state value="P" variable="S1505"/> <bbox w="40.0" h="10.0" x="13387.882" y="2440.5"/> </glyph> <glyph class="state variable" id="_671bb93a-4beb-4730-83b8-8c67be93da20"> <state value="P" variable="S1501"/> <bbox w="40.0" h="10.0" x="13308.992" y="2400.5"/> </glyph> <glyph class="state variable" id="_dfa4a014-ff55-4108-98c1-340d0c2c25f3"> <state value="P" variable="S1504"/> <bbox w="40.0" h="10.0" x="13388.5" y="2400.7148"/> </glyph> <glyph class="state variable" id="_015c11eb-4d09-4849-addb-f38d27913b9b"> <state value="P" variable="S1507"/> <bbox w="40.0" h="10.0" x="13348.404" y="2440.5"/> </glyph> <glyph class="state variable" id="_c9d0c6aa-813f-40d1-8368-de730086ef1f"> <state value="P" variable="S1503"/> <bbox w="40.0" h="10.0" x="13348.532" y="2400.5"/> </glyph> <glyph class="state variable" id="_9d61cfc0-44d7-4adc-80ac-71e6d747c1b2"> <state value="P" variable="S1510"/> <bbox w="40.0" h="10.0" x="13308.5" y="2440.2224"/> </glyph> <glyph class="state variable" id="_b59a0b19-4827-4061-a810-041d965a01d2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13403.5" y="2400.5"/> </glyph> <glyph class="state variable" id="_754deddd-292f-426e-baac-2d4b5d93edfb"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="13391.0" y="2439.6306"/> </glyph> <glyph class="state variable" id="_f51b86b8-b3df-40e8-bf15-1e2991bca208"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="13311.0" y="2440.2224"/> </glyph> <glyph class="state variable" id="_3eaeb46c-4532-4f19-937f-b1639967214e"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13316.492" y="2400.5"/> </glyph> <glyph class="state variable" id="_683b620a-fe8d-4dbb-b476-fd7d2effad3e"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="13311.492" y="2400.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s169_wca1_wca1_sa136"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="13411.5" y="2405.5"/> <glyph class="state variable" id="_f42ed5bb-ffef-44e7-8af9-604b3ddad6ca"> <state value="P" variable="S45"/> <bbox w="30.0" h="10.0" x="13436.404" y="2440.5"/> </glyph> <glyph class="state variable" id="_56a25591-e1ac-4fc2-b12c-0b0cae6af49d"> <state value="P" variable="T41"/> <bbox w="30.0" h="10.0" x="13475.882" y="2440.5"/> </glyph> <glyph class="state variable" id="_41c7ebc1-e9be-4d17-9f07-10618abe4d25"> <state value="P" variable="S37"/> <bbox w="30.0" h="10.0" x="13476.5" y="2400.7148"/> </glyph> <glyph class="state variable" id="_f747c1ea-f482-4934-9973-b250f16c0586"> <state value="P" variable="S33"/> <bbox w="30.0" h="10.0" x="13436.532" y="2400.5"/> </glyph> <glyph class="state variable" id="_273f3468-cbc4-4dea-919c-ba843fc18f2d"> <state value="Ub" variable="K19"/> <bbox w="35.0" h="10.0" x="13394.492" y="2400.5"/> </glyph> <glyph class="state variable" id="_35c4b4df-4ebb-4a37-a610-cb0d897bce66"> <state value="Ub" variable="K49"/> <bbox w="35.0" h="10.0" x="13394.0" y="2440.2224"/> </glyph> <glyph class="state variable" id="_47a62823-3532-47bc-bc52-c8cdbf8a6f9e"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="13476.5" y="2400.7148"/> </glyph> <glyph class="state variable" id="_b650f98b-7aa7-4e5f-898c-2d14c4c37e2a"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="13476.5" y="2400.7148"/> </glyph> <glyph class="state variable" id="_9e30c86e-f4d7-463c-9606-3402ac1913e6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13406.5" y="2420.5"/> </glyph> <glyph class="state variable" id="_007223d6-f8b0-4df2-a7d8-5786d24f8ebe"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="13396.992" y="2400.5"/> </glyph> <glyph class="state variable" id="_0df86149-9874-4bd5-8d6d-d9e8602fdde8"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="13476.5" y="2400.7148"/> </glyph> <glyph class="state variable" id="_f0098b82-a0ca-4cb0-97dc-bdaa7606b525"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13406.5" y="2412.2158"/> </glyph> <glyph class="state variable" id="_4f77f3e0-be1a-48ce-866d-1c96883da5a4"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="13476.5" y="2400.7148"/> </glyph> <glyph class="state variable" id="_9e139c16-7b68-4e8c-8795-f1f7e0a0e7dd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13406.5" y="2420.5"/> </glyph> <glyph class="state variable" id="_8882b12f-5c4b-4928-aa7d-897bc5f10b2b"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="13475.882" y="2440.5"/> </glyph> <glyph class="state variable" id="_78f957ef-e431-4c38-a128-79b066729ab7"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="13476.5" y="2400.7148"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1516_wca1_wca1_sa448"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> </notes> <label text="CUL1"/> <bbox w="80.0" h="40.0" x="13328.5" y="2188.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1517_wca1_wca1_sa449"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 S-phase kinase-associated protein 2 (p45) HUGO:SKP2 HGNC:10901 ENTREZ:6502 UNIPROT:Q13309 GENECARDS:SKP2 REACTOME:405589 KEGG:6502 ATLASONC:GC_SKP2 WIKI:SKP2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15688063 PMID:15340381 PMID:12820959 References_end</body> </html> </notes> <label text="SKP*"/> <bbox w="80.0" h="40.0" x="13411.5" y="2188.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1518_wca1_wca1_sa450"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> </notes> <label text="RBX1"/> <bbox w="80.0" h="40.0" x="13328.5" y="2231.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1519_wca1_wca1_sa451"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Beta-transducin repeat domain HUGO:BTRC HGNC:1144 ENTREZ:8945 UNIPROT:Q9Y297 GENECARDS:BTRC REACTOME:55056 KEGG:8945 ATLASONC:BTRCID451ch10q24 WIKI:BTRC F-box and WD repeat domain containing 11 BTRC2, BTRCP2, Fbw1b, Fbw11, Hos, KIAA0696 HUGO:FBXW11 HGNC:13607 ENTREZ:23291 UNIPROT:Q9UKB1 GENECARDS:FBXW11 REACTOME:55058 KEGG:23291 WIKI:FBXW11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 E3 Ligase subunit References_end Identifiers_begin: Beta-transducin repeat domain HUGO:BTRC HGNC:1144 ENTREZ:8945 UNIPROT:Q9Y297 GENECARDS:BTRC REACTOME:55056 KEGG:8945 ATLASONC:BTRCID451ch10q24 WIKI:BTRC F-box and WD repeat domain containing 11 BTRC2, BTRCP2, Fbw1b, Fbw11, Hos, KIAA0696 HUGO:FBXW11 HGNC:13607 ENTREZ:23291 UNIPROT:Q9UKB1 GENECARDS:FBXW11 REACTOME:55058 KEGG:23291 WIKI:FBXW11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 E3 Ligase subunit References_end</body> </html> Identifiers_begin: Beta-transducin repeat domain HUGO:BTRC HGNC:1144 ENTREZ:8945 UNIPROT:Q9Y297 GENECARDS:BTRC REACTOME:55056 KEGG:8945 ATLASONC:BTRCID451ch10q24 WIKI:BTRC F-box and WD repeat domain containing 11 BTRC2, BTRCP2, Fbw1b, Fbw11, Hos, KIAA0696 HUGO:FBXW11 HGNC:13607 ENTREZ:23291 UNIPROT:Q9UKB1 GENECARDS:FBXW11 REACTOME:55058 KEGG:23291 WIKI:FBXW11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 E3 Ligase subunit References_end</body> </html> </notes> <label text="βTRCP*"/> <bbox w="80.0" h="40.0" x="13411.5" y="2231.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1520_wca1_wca1_sa452"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:TLS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15688063 References_end</body> </html> </notes> <label text="RAD6*"/> <bbox w="80.0" h="40.0" x="13328.5" y="2274.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s597_wca1_wca1_sa453"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> </notes> <label text="E1*"/> <bbox w="80.0" h="40.0" x="13411.5" y="2274.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1521_wca1_wca1_sa454"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: neural precursor cell expressed developmentally down-regulated 8 HUGO:NEDD8 HGNC:7732 ENTREZ:4738 UNIPROT:Q15843 GENECARDS:NEDD8 KEGG:4738 ATLASONC:GC_NEDD8 WIKI:NEDD8 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:NER MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15688063 PMID:19576224 References_end</body> </html> </notes> <label text="NEDD8"/> <bbox w="80.0" h="40.0" x="13411.5" y="2317.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1522_wca1_wca1_sa455"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: G protein HUGO:GPS1 HGNC:4549 ENTREZ:2873 UNIPROT:Q13098 GENECARDS:GPS1 KEGG:2873 ATLASONC:GC_GPS1 WIKI:GPS1 HUGO:GPS2 HGNC:4550 ENTREZ:2874 UNIPROT:Q13227 GENECARDS:GPS2 KEGG:2874 WIKI:GPS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 References_end</body> </html> </notes> <label text="CSN1*"/> <bbox w="80.0" h="40.0" x="13328.5" y="2104.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1523_wca1_wca1_sa456"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) HUGO:COPS2 HGNC:30747 ENTREZ:9318 UNIPROT:P61201 GENECARDS:COPS2 KEGG:9318 ATLASONC:COPS2ID47362ch15q21 WIKI:COPS2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 References_end</body> </html> </notes> <label text="CSN2*"/> <bbox w="80.0" h="40.0" x="13328.5" y="2146.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1524_wca1_wca1_sa457"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis) HUGO:COPS3 HGNC:2239 ENTREZ:8533 UNIPROT:Q9UNS2 GENECARDS:COPS3 KEGG:8533 ATLASONC:GC_COPS3 WIKI:COPS3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 References_end</body> </html> </notes> <label text="CSN3*"/> <bbox w="80.0" h="40.0" x="13411.5" y="2104.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1525_wca1_wca1_sa458"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) HUGO:COPS4 HGNC:16702 ENTREZ:51138 UNIPROT:Q9BT78 GENECARDS:COPS4 KEGG:51138 ATLASONC:GC_COPS4 WIKI:COPS4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 References_end</body> </html> </notes> <label text="CSN4*"/> <bbox w="80.0" h="40.0" x="13411.5" y="2146.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1526_wca1_wca1_sa459"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) HUGO:COPS5 HGNC:2240 ENTREZ:10987 UNIPROT:Q92905 GENECARDS:COPS5 KEGG:10987 ATLASONC:GC_COPS5 WIKI:COPS5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 References_end</body> </html> </notes> <label text="CSN5*"/> <bbox w="80.0" h="40.0" x="13328.5" y="2020.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1527_wca1_wca1_sa460"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis) HUGO:COPS6 HGNC:21749 ENTREZ:10980 UNIPROT:Q7L5N1 GENECARDS:COPS6 KEGG:10980 ATLASONC:GC_COPS6 WIKI:COPS6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 References_end</body> </html> </notes> <label text="CSN6*"/> <bbox w="80.0" h="40.0" x="13328.5" y="2062.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1528_wca1_wca1_sa461"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) HUGO:COPS7A HGNC:16758 ENTREZ:50813 UNIPROT:Q9UBW8 GENECARDS:COPS7A KEGG:50813 ATLASONC:GC_COPS7A WIKI:COPS7A COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis) HUGO:COPS7B HGNC:16760 ENTREZ:64708 UNIPROT:Q9H9Q2 GENECARDS:COPS7B KEGG:64708 ATLASONC:GC_COPS7B WIKI:COPS7B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 References_end</body> </html> </notes> <label text="CSN7*"/> <bbox w="80.0" h="40.0" x="13411.5" y="2020.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1529_wca1_wca1_sa462"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) HUGO:COPS8 HGNC:24335 ENTREZ:10920 UNIPROT:Q99627 GENECARDS:COPS8 KEGG:10920 ATLASONC:GC_COPS8 WIKI:COPS8 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 References_end</body> </html> </notes> <label text="CSN8*"/> <bbox w="80.0" h="40.0" x="13411.5" y="2062.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1530_wca1_wca1_sa464"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ubiquitin specific peptidase 15 HUGO:USP15 HGNC:12613 ENTREZ:9958 UNIPROT:Q9Y4E8 GENECARDS:USP15 REACTOME:66846 KEGG:9958 ATLASONC:USP15ID44585ch12q14 WIKI:USP15 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 PMID:19576224 References_end</body> </html> </notes> <label text="USP15"/> <bbox w="80.0" h="40.0" x="13328.5" y="1979.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1531_wca1_wca1_sa465"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein kinase D1 HUGO:PRKD1 HGNC:9407 ENTREZ:5587 UNIPROT:Q15139 GENECARDS:PRKD1 REACTOME:58211 KEGG:5587 ATLASONC:PRKCMID41860ch14q11 WIKI:PRKD1 protein kinase D2 HUGO:PRKD2 HGNC:17293 ENTREZ:25865 UNIPROT:Q9BZL6 GENECARDS:PRKD2 KEGG:25865 ATLASONC:GC_PRKD2 WIKI:PRKD2 protein kinase D3 HUGO:PRKD3 HGNC:9408 ENTREZ:23683 UNIPROT:O94806 GENECARDS:PRKD3 KEGG:23683 ATLASONC:GC_PRKD3 WIKI:PRKD3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19576224 PMID:19849719 References_end</body> </html> </notes> <label text="PKD*"/> <bbox w="80.0" h="40.0" x="13410.5" y="1980.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1719_wca1_wca1_sa629"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2β*"/> <bbox w="80.0" h="40.0" x="13327.053" y="1936.0526"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1533_wca1_wca1_sa630"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 alpha prime polypeptide HUGO:CSNK2A2 HGNC:2459 ENTREZ:1459 UNIPROT:P19784 GENECARDS:CSNK2A2 REACTOME:57879 KEGG:1459 ATLASONC:GC_CSNK2A2 WIKI:CSNK2A2 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 alpha prime polypeptide HUGO:CSNK2A2 HGNC:2459 ENTREZ:1459 UNIPROT:P19784 GENECARDS:CSNK2A2 REACTOME:57879 KEGG:1459 ATLASONC:GC_CSNK2A2 WIKI:CSNK2A2 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2α'*"/> <bbox w="80.0" h="40.0" x="13409.053" y="1934.0526"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1534_wca1_wca1_sa631"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 alpha 1 polypeptide HUGO:CSNK2A1 HGNC:2457 ENTREZ:1457 UNIPROT:P68400 GENECARDS:CSNK2A1 REACTOME:201673 KEGG:1457 ATLASONC:GC_CSNK2A1 WIKI:CSNK2A1 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 alpha 1 polypeptide HUGO:CSNK2A1 HGNC:2457 ENTREZ:1457 UNIPROT:P68400 GENECARDS:CSNK2A1 REACTOME:201673 KEGG:1457 ATLASONC:GC_CSNK2A1 WIKI:CSNK2A1 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2α*"/> <bbox w="80.0" h="40.0" x="13327.053" y="1936.0526"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1719_wca1_wca1_sa632"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2β*"/> <bbox w="80.0" h="40.0" x="13331.053" y="1896.0526"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1575_wca1_wca1_sa686"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fas (TNFRSF6) associated factor 1 HUGO:FAF1 HGNC:3578 ENTREZ:11124 UNIPROT:Q9UNN5 GENECARDS:FAF1 KEGG:11124 ATLASONC:GC_FAF1 WIKI:FAF1 Fas associated factor family member 2 HUGO:FAF2 HGNC:24666 ENTREZ:23197 UNIPROT:Q96CS3 GENECARDS:FAF2 KEGG:23197 WIKI:FAF2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19597341 References_end</body> </html> </notes> <label text="FAF*"/> <bbox w="80.0" h="40.0" x="13411.0" y="1895.5"/> </glyph> <glyph class="simple chemical" id="wca1_wca1_s1684_wca1_wca1_sa719"> <label text="PtdIns(4,5)-P2"/> <bbox w="70.0" h="25.0" x="13415.0" y="2465.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1685_wca1_wca1_sa720"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="13329.0" y="2453.25"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1720_wca1_wca1_csa46" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CUL1:E1*:FAF*:NEDD8:RAD6*:RBX1:SKP*:_beta_TRCP* Identifiers_end References_begin: s_wca1_re46(MAP:survival): PMID:15688063 PMID:22730322 FAF1 acts as scaffold protein s_wca1_re47(MAP:survival): PMID:19576224 PMID:17143292 PMID:10023660 PMID:21411632 PMID:22730322 PMID:22682247 FAF1 enhances poly-ubiquitination of beta-catenin by acting as scaffold protein Intact destruction complex in the proteosome complex References_end</body> </html> </notes> <label text="(CRL)"/> <bbox w="212.0" h="216.0" x="13032.0" y="2047.0"/> <glyph class="macromolecule" id="wca1_wca1_s558_wca1_wca1_sa429"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> </notes> <label text="CUL1"/> <bbox w="80.0" h="40.0" x="13056.5" y="2071.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s559_wca1_wca1_sa430"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 S-phase kinase-associated protein 2 (p45) HUGO:SKP2 HGNC:10901 ENTREZ:6502 UNIPROT:Q13309 GENECARDS:SKP2 REACTOME:405589 KEGG:6502 ATLASONC:GC_SKP2 WIKI:SKP2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15688063 PMID:15340381 PMID:12820959 References_end</body> </html> </notes> <label text="SKP*"/> <bbox w="80.0" h="40.0" x="13139.0" y="2071.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s560_wca1_wca1_sa431"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> </notes> <label text="RBX1"/> <bbox w="80.0" h="40.0" x="13056.5" y="2114.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s561_wca1_wca1_sa432"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Beta-transducin repeat domain HUGO:BTRC HGNC:1144 ENTREZ:8945 UNIPROT:Q9Y297 GENECARDS:BTRC REACTOME:55056 KEGG:8945 ATLASONC:BTRCID451ch10q24 WIKI:BTRC F-box and WD repeat domain containing 11 BTRC2, BTRCP2, Fbw1b, Fbw11, Hos, KIAA0696 HUGO:FBXW11 HGNC:13607 ENTREZ:23291 UNIPROT:Q9UKB1 GENECARDS:FBXW11 REACTOME:55058 KEGG:23291 WIKI:FBXW11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 E3 Ligase subunit References_end Identifiers_begin: Beta-transducin repeat domain HUGO:BTRC HGNC:1144 ENTREZ:8945 UNIPROT:Q9Y297 GENECARDS:BTRC REACTOME:55056 KEGG:8945 ATLASONC:BTRCID451ch10q24 WIKI:BTRC F-box and WD repeat domain containing 11 BTRC2, BTRCP2, Fbw1b, Fbw11, Hos, KIAA0696 HUGO:FBXW11 HGNC:13607 ENTREZ:23291 UNIPROT:Q9UKB1 GENECARDS:FBXW11 REACTOME:55058 KEGG:23291 WIKI:FBXW11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 E3 Ligase subunit References_end</body> </html> Identifiers_begin: Beta-transducin repeat domain HUGO:BTRC HGNC:1144 ENTREZ:8945 UNIPROT:Q9Y297 GENECARDS:BTRC REACTOME:55056 KEGG:8945 ATLASONC:BTRCID451ch10q24 WIKI:BTRC F-box and WD repeat domain containing 11 BTRC2, BTRCP2, Fbw1b, Fbw11, Hos, KIAA0696 HUGO:FBXW11 HGNC:13607 ENTREZ:23291 UNIPROT:Q9UKB1 GENECARDS:FBXW11 REACTOME:55058 KEGG:23291 WIKI:FBXW11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 E3 Ligase subunit References_end</body> </html> </notes> <label text="βTRCP*"/> <bbox w="80.0" h="40.0" x="13139.0" y="2114.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s563_wca1_wca1_sa433"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:TLS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15688063 References_end</body> </html> </notes> <label text="RAD6*"/> <bbox w="80.0" h="40.0" x="13056.5" y="2157.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s564_wca1_wca1_sa434"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> </notes> <label text="E1*"/> <bbox w="80.0" h="40.0" x="13139.0" y="2157.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s565_wca1_wca1_sa436"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: neural precursor cell expressed developmentally down-regulated 8 HUGO:NEDD8 HGNC:7732 ENTREZ:4738 UNIPROT:Q15843 GENECARDS:NEDD8 KEGG:4738 ATLASONC:GC_NEDD8 WIKI:NEDD8 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:NER MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15688063 PMID:19576224 References_end</body> </html> </notes> <label text="NEDD8"/> <bbox w="80.0" h="40.0" x="13139.0" y="2200.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1574_wca1_wca1_sa685"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fas (TNFRSF6) associated factor 1 HUGO:FAF1 HGNC:3578 ENTREZ:11124 UNIPROT:Q9UNN5 GENECARDS:FAF1 KEGG:11124 ATLASONC:GC_FAF1 WIKI:FAF1 Fas associated factor family member 2 HUGO:FAF2 HGNC:24666 ENTREZ:23197 UNIPROT:Q96CS3 GENECARDS:FAF2 KEGG:23197 WIKI:FAF2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19597341 References_end</body> </html> </notes> <label text="FAF*"/> <bbox w="80.0" h="40.0" x="13057.0" y="2201.5"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1721_wca1_wca1_csa47" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK2_alpha_:CK2_alpha_*:CK2_beta_*:CSN1*:CSN2*:CSN3*:CSN4*:CSN5*:CSN6*:CSN7*:CSN8*:PKD*:USP15 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 s_wca1_re47(MAP:survival): PMID:19576224 PMID:17143292 PMID:10023660 PMID:21411632 PMID:22730322 PMID:22682247 FAF1 enhances poly-ubiquitination of beta-catenin by acting as scaffold protein Intact destruction complex in the proteosome complex References_end</body> </html> </notes> <label text="(COP9_signalosome)"/> <bbox w="585.0" h="119.0" x="12684.0" y="1841.0"/> <glyph class="macromolecule" id="wca1_wca1_s566_wca1_wca1_sa437"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: G protein HUGO:GPS1 HGNC:4549 ENTREZ:2873 UNIPROT:Q13098 GENECARDS:GPS1 KEGG:2873 ATLASONC:GC_GPS1 WIKI:GPS1 HUGO:GPS2 HGNC:4550 ENTREZ:2874 UNIPROT:Q13227 GENECARDS:GPS2 KEGG:2874 WIKI:GPS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 References_end</body> </html> </notes> <label text="CSN1*"/> <bbox w="80.0" h="40.0" x="12695.0" y="1862.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s567_wca1_wca1_sa438"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) HUGO:COPS2 HGNC:30747 ENTREZ:9318 UNIPROT:P61201 GENECARDS:COPS2 KEGG:9318 ATLASONC:COPS2ID47362ch15q21 WIKI:COPS2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 References_end</body> </html> </notes> <label text="CSN2*"/> <bbox w="80.0" h="40.0" x="12696.0" y="1903.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s568_wca1_wca1_sa439"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis) HUGO:COPS3 HGNC:2239 ENTREZ:8533 UNIPROT:Q9UNS2 GENECARDS:COPS3 KEGG:8533 ATLASONC:GC_COPS3 WIKI:COPS3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 References_end</body> </html> </notes> <label text="CSN3*"/> <bbox w="80.0" h="40.0" x="12776.0" y="1864.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s569_wca1_wca1_sa440"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) HUGO:COPS4 HGNC:16702 ENTREZ:51138 UNIPROT:Q9BT78 GENECARDS:COPS4 KEGG:51138 ATLASONC:GC_COPS4 WIKI:COPS4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 References_end</body> </html> </notes> <label text="CSN4*"/> <bbox w="80.0" h="40.0" x="12777.0" y="1903.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s570_wca1_wca1_sa441"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) HUGO:COPS5 HGNC:2240 ENTREZ:10987 UNIPROT:Q92905 GENECARDS:COPS5 KEGG:10987 ATLASONC:GC_COPS5 WIKI:COPS5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 References_end</body> </html> </notes> <label text="CSN5*"/> <bbox w="80.0" h="40.0" x="12857.0" y="1864.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s571_wca1_wca1_sa442"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis) HUGO:COPS6 HGNC:21749 ENTREZ:10980 UNIPROT:Q7L5N1 GENECARDS:COPS6 KEGG:10980 ATLASONC:GC_COPS6 WIKI:COPS6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 References_end</body> </html> </notes> <label text="CSN6*"/> <bbox w="80.0" h="40.0" x="12859.0" y="1902.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s572_wca1_wca1_sa443"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) HUGO:COPS7A HGNC:16758 ENTREZ:50813 UNIPROT:Q9UBW8 GENECARDS:COPS7A KEGG:50813 ATLASONC:GC_COPS7A WIKI:COPS7A COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis) HUGO:COPS7B HGNC:16760 ENTREZ:64708 UNIPROT:Q9H9Q2 GENECARDS:COPS7B KEGG:64708 ATLASONC:GC_COPS7B WIKI:COPS7B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 References_end</body> </html> </notes> <label text="CSN7*"/> <bbox w="80.0" h="40.0" x="12935.0" y="1863.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s573_wca1_wca1_sa444"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) HUGO:COPS8 HGNC:24335 ENTREZ:10920 UNIPROT:Q99627 GENECARDS:COPS8 KEGG:10920 ATLASONC:GC_COPS8 WIKI:COPS8 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 References_end</body> </html> </notes> <label text="CSN8*"/> <bbox w="80.0" h="40.0" x="12937.0" y="1901.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s577_wca1_wca1_sa445"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 alpha 1 polypeptide HUGO:CSNK2A1 HGNC:2457 ENTREZ:1457 UNIPROT:P68400 GENECARDS:CSNK2A1 REACTOME:201673 KEGG:1457 ATLASONC:GC_CSNK2A1 WIKI:CSNK2A1 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 alpha 1 polypeptide HUGO:CSNK2A1 HGNC:2457 ENTREZ:1457 UNIPROT:P68400 GENECARDS:CSNK2A1 REACTOME:201673 KEGG:1457 ATLASONC:GC_CSNK2A1 WIKI:CSNK2A1 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2α*"/> <bbox w="80.0" h="40.0" x="13016.0" y="1862.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s574_wca1_wca1_sa446"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ubiquitin specific peptidase 15 HUGO:USP15 HGNC:12613 ENTREZ:9958 UNIPROT:Q9Y4E8 GENECARDS:USP15 REACTOME:66846 KEGG:9958 ATLASONC:USP15ID44585ch12q14 WIKI:USP15 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 PMID:19576224 References_end</body> </html> </notes> <label text="USP15"/> <bbox w="80.0" h="40.0" x="13100.0" y="1903.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s575_wca1_wca1_sa447"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein kinase D1 HUGO:PRKD1 HGNC:9407 ENTREZ:5587 UNIPROT:Q15139 GENECARDS:PRKD1 REACTOME:58211 KEGG:5587 ATLASONC:PRKCMID41860ch14q11 WIKI:PRKD1 protein kinase D2 HUGO:PRKD2 HGNC:17293 ENTREZ:25865 UNIPROT:Q9BZL6 GENECARDS:PRKD2 KEGG:25865 ATLASONC:GC_PRKD2 WIKI:PRKD2 protein kinase D3 HUGO:PRKD3 HGNC:9408 ENTREZ:23683 UNIPROT:O94806 GENECARDS:PRKD3 KEGG:23683 ATLASONC:GC_PRKD3 WIKI:PRKD3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19576224 PMID:19849719 References_end</body> </html> </notes> <label text="PKD*"/> <bbox w="80.0" h="40.0" x="13180.0" y="1862.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1298_wca1_wca1_sa628"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 alpha prime polypeptide HUGO:CSNK2A2 HGNC:2459 ENTREZ:1459 UNIPROT:P19784 GENECARDS:CSNK2A2 REACTOME:57879 KEGG:1459 ATLASONC:GC_CSNK2A2 WIKI:CSNK2A2 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 alpha prime polypeptide HUGO:CSNK2A2 HGNC:2459 ENTREZ:1459 UNIPROT:P19784 GENECARDS:CSNK2A2 REACTOME:57879 KEGG:1459 ATLASONC:GC_CSNK2A2 WIKI:CSNK2A2 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2α'*"/> <bbox w="80.0" h="40.0" x="13018.053" y="1901.9474"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1302_wca1_wca1_sa633"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2β*"/> <bbox w="80.0" h="40.0" x="13099.053" y="1865.0526"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1722_wca1_wca1_csa20" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC:AXIN*:CK1_alpha_*:GSK3*:PP2A_C*:PR55_alpha_*:PR65_A*:_beta_-Catenin* Identifiers_end References_begin: s_wca1_re20:(MAP:survival) PMID:19556239 References_end</body> </html> </notes> <label text="(Destruction_complex_PP2A)"/> <bbox w="276.0" h="163.0" x="12843.5" y="1636.5"/> <glyph class="macromolecule" id="wca1_wca1_s1490_wca1_wca1_sa109"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="12854.5" y="1734.5"/> <glyph class="state variable" id="_92dece4b-e807-4188-9343-5a77c23144b3"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="12916.382" y="1769.5"/> </glyph> <glyph class="state variable" id="_b03d29b6-2c80-4377-b0ff-8f558a2e8ac1"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="12837.492" y="1729.5"/> </glyph> <glyph class="state variable" id="_c701111d-0846-42c0-8643-a5b3c224e00e"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="12917.0" y="1729.7147"/> </glyph> <glyph class="state variable" id="_4b30f0be-a33c-41b1-99bb-0571856487b1"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="12876.904" y="1769.5"/> </glyph> <glyph class="state variable" id="_9ec6ac71-14e7-4323-bc8d-8a498e8e3304"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="12877.032" y="1729.5"/> </glyph> <glyph class="state variable" id="_8ec1a614-5107-4f29-9fb2-cba921c97dd6"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="12837.0" y="1769.2223"/> </glyph> <glyph class="state variable" id="_a39eb2ad-c945-47f7-87ec-55414747d438"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12929.5" y="1729.5"/> </glyph> <glyph class="state variable" id="_0199cd8a-e53b-4907-9516-3e80881f1628"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="12917.0" y="1768.6306"/> </glyph> <glyph class="state variable" id="_98f63844-9d4d-4d6e-ace9-595a580cdb11"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="12837.0" y="1769.2223"/> </glyph> <glyph class="state variable" id="_718a26ab-a60c-4c96-ad13-ee09430127ad"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12842.492" y="1729.5"/> </glyph> <glyph class="state variable" id="_c664fc56-e0d2-4f2b-939a-6f5fe4a51110"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="12837.492" y="1729.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1491_wca1_wca1_sa110"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="12938.5" y="1646.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1492_wca1_wca1_sa111"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="12854.5" y="1646.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s139_wca1_wca1_sa112"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="12940.0" y="1690.0"/> <glyph class="state variable" id="_2b54e2b6-a425-4cf9-9e2f-47d17c1f10b7"> <state value="P" variable="S45"/> <bbox w="30.0" h="10.0" x="12964.904" y="1725.0"/> </glyph> <glyph class="state variable" id="_17cf58b6-c54b-404d-9ce0-a8ba0c6592b4"> <state value="P" variable="T41"/> <bbox w="30.0" h="10.0" x="13004.382" y="1725.0"/> </glyph> <glyph class="state variable" id="_a77d13c3-33ed-49cd-b2b1-48fc8b9697ad"> <state value="P" variable="S37"/> <bbox w="30.0" h="10.0" x="13005.0" y="1685.2147"/> </glyph> <glyph class="state variable" id="_d0b6d918-6dd5-4cd8-af6c-9910883ba888"> <state value="P" variable="S33"/> <bbox w="30.0" h="10.0" x="12965.032" y="1685.0"/> </glyph> <glyph class="state variable" id="_f3dead68-908e-4852-88db-ac7206f90ed1"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="12927.992" y="1685.0"/> </glyph> <glyph class="state variable" id="_73b93178-e02a-4e91-a5e0-21fd5c95bb51"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="12927.5" y="1724.7223"/> </glyph> <glyph class="state variable" id="_dd323105-6eea-4d95-8fdb-cde4637a884d"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="13005.0" y="1685.2147"/> </glyph> <glyph class="state variable" id="_48b99a21-7dd8-4799-9575-2b792ce40280"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="13005.0" y="1685.2147"/> </glyph> <glyph class="state variable" id="_9d99d2bd-1e32-4c25-a23d-5ebd6728592a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12935.0" y="1705.0"/> </glyph> <glyph class="state variable" id="_44624542-3baa-4d58-948e-489afac3106c"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="12925.492" y="1685.0"/> </glyph> <glyph class="state variable" id="_5c2656b9-00d9-4319-9acf-a3079a92926a"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="13005.0" y="1685.2147"/> </glyph> <glyph class="state variable" id="_e80daf7e-936e-42c4-8b2e-87f905d8bc81"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12935.0" y="1696.7157"/> </glyph> <glyph class="state variable" id="_c47a2f77-e8da-45d3-bc04-021077c56f02"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="13005.0" y="1685.2147"/> </glyph> <glyph class="state variable" id="_b20162e2-916a-46d8-85bd-49bfdcbb0fb1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12935.0" y="1705.0"/> </glyph> <glyph class="state variable" id="_2527a9b6-648e-490c-b506-5ac18d14de26"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="13004.382" y="1725.0"/> </glyph> <glyph class="state variable" id="_fb6ee33d-ac49-4c52-a0cd-2b81677d58b9"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="13005.0" y="1685.2147"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1493_wca1_wca1_sa113"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="12855.5" y="1690.9375"/> <glyph class="state variable" id="_164dd36e-c1a8-4614-90fc-d5039c6b1ea9"> <state value="P" variable="S80"/> <bbox w="30.0" h="10.0" x="12840.992" y="1685.9375"/> </glyph> <glyph class="state variable" id="_67eb34e3-886c-43ed-8526-8bab7458f685"> <state value="P" variable="S82"/> <bbox w="30.0" h="10.0" x="12880.532" y="1685.9375"/> </glyph> <glyph class="state variable" id="_9c331118-6831-4fe3-a01f-58ee78159382"> <state value="P" variable="S222"/> <bbox w="35.0" h="10.0" x="12918.0" y="1686.1522"/> </glyph> <glyph class="state variable" id="_1e36f83f-5710-42c1-abd6-0641c872805c"> <state value="P" variable="S473"/> <bbox w="35.0" h="10.0" x="12917.382" y="1725.9375"/> </glyph> <glyph class="state variable" id="_0bd760c3-5081-4005-b257-193035f9ffc2"> <state value="P" variable="S614"/> <bbox w="35.0" h="10.0" x="12877.904" y="1725.9375"/> </glyph> <glyph class="state variable" id="_2c3660db-5771-4995-8175-1d7d2f96be3b"> <state value="P" variable="S621"/> <bbox w="35.0" h="10.0" x="12838.0" y="1725.6598"/> </glyph> <glyph class="state variable" id="_0ec9fb57-3cb7-4fc7-a97c-24d3c4efef81"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="12882.904" y="1725.9375"/> </glyph> <glyph class="state variable" id="_5c7073c8-fdd3-4bcb-bf3a-268f09853f7a"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="12922.382" y="1725.9375"/> </glyph> <glyph class="state variable" id="_34e7093d-3bc6-4f86-ab8d-f69e623f1be4"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12928.0" y="1686.1522"/> </glyph> <glyph class="state variable" id="_cee47d15-8f0d-4039-a40a-a3f32b43da2d"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12843.0" y="1725.6598"/> </glyph> <glyph class="state variable" id="_83674187-f70f-4e05-912b-83b679d0dea1"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12848.492" y="1685.9375"/> </glyph> <glyph class="state variable" id="_fb3a28a8-9f1e-4f25-9ab4-d0b1ca501cdb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12850.5" y="1685.9375"/> </glyph> <glyph class="state variable" id="_714b7f36-5ab9-4cac-a51b-51517e2368aa"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12930.5" y="1685.9375"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1494_wca1_wca1_sa114"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 References_end Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> </notes> <label text="PP2A_C*"/> <bbox w="80.0" h="40.0" x="13026.5" y="1647.5"/> <glyph class="state variable" id="_671c2680-dccf-4f60-af12-1c18cfa88223"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13021.5" y="1662.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1495_wca1_wca1_sa115"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 2 regulatory subunit B alpha HUGO:PPP2R2A HGNC:9304 ENTREZ:5520 UNIPROT:P63151 GENECARDS:PPP2R2A REACTOME:49129 KEGG:5520 ATLASONC:GC_PPP2R2A WIKI:PPP2R2A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18588945 References_end</body> </html> </notes> <label text="PR55α*"/> <bbox w="80.0" h="40.0" x="13026.5" y="1689.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1496_wca1_wca1_sa116"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 2 regulatory subunit A alpha HUGO:PPP2R1A HGNC:9302 ENTREZ:5518 UNIPROT:P30153 GENECARDS:PPP2R1A REACTOME:49125 KEGG:5518 ATLASONC:GC_PPP2R1A WIKI:PPP2R1A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18588945 References_end</body> </html> </notes> <label text="PR65_A*"/> <bbox w="80.0" h="40.0" x="13026.5" y="1732.5"/> </glyph> <glyph class="macromolecule" id="wca1_s1332_wca1_sa1306"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re34(MAP:survival): PMID:21498506 Membrane-bound AMER1 acts as scaffold and brings APC to the membrane s_wca1_re59:(MAP:survival) PMID:21304492 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="12942.0" y="1732.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1723_wca1_wca1_csa21" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC:AXIN*:CK1_alpha_*:GSK3*:PP2A_C*:PR55_alpha_*:PR65_A*:_beta_-Catenin* Identifiers_end References_begin: s_wca1_re21:(MAP:survival) PMID:19556239 References_end</body> </html> </notes> <label text="(Destruction_complex_PP2A)"/> <bbox w="276.0" h="163.0" x="12843.5" y="1405.5"/> <glyph class="macromolecule" id="wca1_wca1_s136_wca1_wca1_sa117"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="12854.5" y="1503.5"/> <glyph class="state variable" id="_19ff4525-1cc2-4051-a7d8-17504053ae68"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="12916.382" y="1538.5"/> </glyph> <glyph class="state variable" id="_d5f485ff-4d18-4209-b780-a6b15e60fb51"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="12837.492" y="1498.5"/> </glyph> <glyph class="state variable" id="_db614d2b-8908-4c43-a531-9b75d6acd40b"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="12917.0" y="1498.7147"/> </glyph> <glyph class="state variable" id="_542b9603-3d06-41fa-8f0e-c401540f8ad5"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="12876.904" y="1538.5"/> </glyph> <glyph class="state variable" id="_9812cd02-76b8-4020-a1f8-9a40e2f25924"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="12877.032" y="1498.5"/> </glyph> <glyph class="state variable" id="_1f603339-f55b-45bb-9c06-5d0105db2e68"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="12837.0" y="1538.2223"/> </glyph> <glyph class="state variable" id="_ddb0e005-6ff4-47df-9aea-0b780192c755"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12929.5" y="1498.5"/> </glyph> <glyph class="state variable" id="_a57e9652-b226-4d2f-b65f-1e45c8a601bd"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="12917.0" y="1537.6306"/> </glyph> <glyph class="state variable" id="_9d5d0ca6-c531-4199-87bc-f2d046d322b1"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="12837.0" y="1538.2223"/> </glyph> <glyph class="state variable" id="_53c908a0-30c0-4464-9cfb-f62fa2a57a34"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12842.492" y="1498.5"/> </glyph> <glyph class="state variable" id="_07cf6059-35da-49a4-aeb4-34de100f9ebd"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="12837.492" y="1498.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s137_wca1_wca1_sa118"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="12938.5" y="1415.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s138_wca1_wca1_sa119"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="12854.5" y="1415.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s155_wca1_wca1_sa120"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="12940.0" y="1459.0"/> <glyph class="state variable" id="_3d1dd1fe-b5f7-449f-b87e-0a840a2b7490"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="12967.404" y="1494.0"/> </glyph> <glyph class="state variable" id="_2de75c59-3e16-4dbc-b0fc-4fc0bb57652b"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="13006.882" y="1494.0"/> </glyph> <glyph class="state variable" id="_e1233a3b-7281-491f-9985-2872de4f6d0b"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="13007.5" y="1454.2147"/> </glyph> <glyph class="state variable" id="_379e6573-1e91-4175-81cb-c30c8ca469e1"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="12967.532" y="1454.0"/> </glyph> <glyph class="state variable" id="_85827ed0-2452-4af9-a25e-068a13e2b2b5"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="12927.992" y="1454.0"/> </glyph> <glyph class="state variable" id="_ca5a9503-b48b-4541-ab37-91999c2271c6"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="12927.5" y="1493.7223"/> </glyph> <glyph class="state variable" id="_69bbc66b-37ef-4548-9a9f-15998aa5412f"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="13005.0" y="1454.2147"/> </glyph> <glyph class="state variable" id="_fa6d202e-461d-4000-aa34-ed96d41460df"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="13005.0" y="1454.2147"/> </glyph> <glyph class="state variable" id="_091abe26-68ed-4934-8bf1-db131671e334"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12935.0" y="1474.0"/> </glyph> <glyph class="state variable" id="_3b49c6b1-1acf-46e2-b5a5-cc49d70316a8"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="12925.492" y="1454.0"/> </glyph> <glyph class="state variable" id="_c14a4770-4c5a-4d72-82e2-645fbc9da112"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="13005.0" y="1454.2147"/> </glyph> <glyph class="state variable" id="_15dd062a-de99-46e8-9b85-ec19c24ab322"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12935.0" y="1465.7157"/> </glyph> <glyph class="state variable" id="_2d854bd2-fb73-4e04-b383-fc5b5b99a715"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="13005.0" y="1454.2147"/> </glyph> <glyph class="state variable" id="_6eb2f13e-db3f-4129-8261-53cfd7e65482"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12935.0" y="1474.0"/> </glyph> <glyph class="state variable" id="_3ef3b9b8-666b-4fd3-a156-03fd360b2198"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="13004.382" y="1494.0"/> </glyph> <glyph class="state variable" id="_4af98f95-455c-406e-be7a-fb4df6675e6f"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="13005.0" y="1454.2147"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s140_wca1_wca1_sa121"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="12855.5" y="1459.9375"/> <glyph class="state variable" id="_a2b8be46-b03f-42e1-bfcd-57c736ba2a91"> <state value="P" variable="S80"/> <bbox w="30.0" h="10.0" x="12840.992" y="1454.9375"/> </glyph> <glyph class="state variable" id="_8b6fefae-0cf3-4900-bc80-f76910663475"> <state value="P" variable="S82"/> <bbox w="30.0" h="10.0" x="12880.532" y="1454.9375"/> </glyph> <glyph class="state variable" id="_25330752-417e-46ae-9655-3f989597f78c"> <state value="P" variable="S222"/> <bbox w="35.0" h="10.0" x="12918.0" y="1455.1522"/> </glyph> <glyph class="state variable" id="_c9c6ab47-114d-4468-8e24-9b150577d972"> <state value="P" variable="S473"/> <bbox w="35.0" h="10.0" x="12917.382" y="1494.9375"/> </glyph> <glyph class="state variable" id="_7b5966f7-6cdb-4ec5-b7f1-aa479b62e33e"> <state value="P" variable="S614"/> <bbox w="35.0" h="10.0" x="12877.904" y="1494.9375"/> </glyph> <glyph class="state variable" id="_0c401c63-ccf8-454b-b97d-69bb463ad6bb"> <state value="P" variable="S621"/> <bbox w="35.0" h="10.0" x="12838.0" y="1494.6598"/> </glyph> <glyph class="state variable" id="_53bec709-0e74-42b2-814a-854bea65d0da"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="12882.904" y="1494.9375"/> </glyph> <glyph class="state variable" id="_25efb9c0-59cd-417e-8de9-c85b0ca292ea"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="12922.382" y="1494.9375"/> </glyph> <glyph class="state variable" id="_272a3dc3-247c-4493-a306-475242bfae9a"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12928.0" y="1455.1522"/> </glyph> <glyph class="state variable" id="_6e0f24de-3894-4bbe-ac7d-6792aef61049"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12843.0" y="1494.6598"/> </glyph> <glyph class="state variable" id="_47068fc9-6b8b-4ccf-8ce9-1d7f14e50014"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="12848.492" y="1454.9375"/> </glyph> <glyph class="state variable" id="_e4ea30f1-8c6a-409c-8ba6-3a3d79ec228f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12850.5" y="1454.9375"/> </glyph> <glyph class="state variable" id="_eb932e7b-c195-4b1d-9034-e7cb3a22adbc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12930.5" y="1454.9375"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s141_wca1_wca1_sa122"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 References_end Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> </notes> <label text="PP2A_C*"/> <bbox w="80.0" h="40.0" x="13026.5" y="1416.5"/> <glyph class="state variable" id="_dcde9d09-89d2-4dd1-a790-6a145b39b762"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13021.5" y="1431.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s142_wca1_wca1_sa123"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 2 regulatory subunit B alpha HUGO:PPP2R2A HGNC:9304 ENTREZ:5520 UNIPROT:P63151 GENECARDS:PPP2R2A REACTOME:49129 KEGG:5520 ATLASONC:GC_PPP2R2A WIKI:PPP2R2A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18588945 References_end</body> </html> </notes> <label text="PR55α*"/> <bbox w="80.0" h="40.0" x="13026.5" y="1458.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s143_wca1_wca1_sa124"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 2 regulatory subunit A alpha HUGO:PPP2R1A HGNC:9302 ENTREZ:5518 UNIPROT:P30153 GENECARDS:PPP2R1A REACTOME:49125 KEGG:5518 ATLASONC:GC_PPP2R1A WIKI:PPP2R1A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18588945 References_end</body> </html> </notes> <label text="PR65_A*"/> <bbox w="80.0" h="40.0" x="13026.5" y="1501.5"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1724_wca1_wca1_csa19" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PP2A_C*:PR55_alpha_*:PR65_A* Identifiers_end References_begin: s_wca1_re20:(MAP:survival) PMID:19556239 References_end</body> </html> </notes> <label text="(PP2A_PR55α)"/> <bbox w="103.0" h="159.0" x="12701.0" y="1412.0"/> <glyph class="macromolecule" id="wca1_wca1_s132_wca1_wca1_sa106"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 2 regulatory subunit A alpha HUGO:PPP2R1A HGNC:9302 ENTREZ:5518 UNIPROT:P30153 GENECARDS:PPP2R1A REACTOME:49125 KEGG:5518 ATLASONC:GC_PPP2R1A WIKI:PPP2R1A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18588945 References_end</body> </html> </notes> <label text="PR65_A*"/> <bbox w="80.0" h="40.0" x="12713.0" y="1508.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s133_wca1_wca1_sa107"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 References_end Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> </notes> <label text="PP2A_C*"/> <bbox w="80.0" h="40.0" x="12713.0" y="1423.0"/> <glyph class="state variable" id="_5fcb3363-a86d-4b72-8f90-e6d85008c524"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12708.0" y="1438.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s134_wca1_wca1_sa108"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 2 regulatory subunit B alpha HUGO:PPP2R2A HGNC:9304 ENTREZ:5520 UNIPROT:P63151 GENECARDS:PPP2R2A REACTOME:49129 KEGG:5520 ATLASONC:GC_PPP2R2A WIKI:PPP2R2A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18588945 References_end</body> </html> </notes> <label text="PR55α*"/> <bbox w="80.0" h="40.0" x="12713.0" y="1465.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1725_wca1_wca1_csa51" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK2_alpha_:CK2_alpha_*:CK2_beta_*:CSN1*:CSN2*:CSN3*:CSN4*:CSN5*:CSN6*:CSN7*:CSN8*:CUL1:NEDD8:PKD*:RAD6*:RBX1:SKP*:USP15:_beta_TRCP* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17143292 s_wca1_re49:(MAP:survival) PMID:19576224 References_end</body> </html> </notes> <label text="(CSN_CRL_Destruction_complex)"/> <bbox w="195.0" h="457.0" x="13313.5" y="1365.0"/> <glyph class="macromolecule" id="wca1_wca1_s579_wca1_wca1_sa474"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> </notes> <label text="CUL1"/> <bbox w="80.0" h="40.0" x="13328.5" y="1664.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s580_wca1_wca1_sa475"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 S-phase kinase-associated protein 2 (p45) HUGO:SKP2 HGNC:10901 ENTREZ:6502 UNIPROT:Q13309 GENECARDS:SKP2 REACTOME:405589 KEGG:6502 ATLASONC:GC_SKP2 WIKI:SKP2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15688063 PMID:15340381 PMID:12820959 References_end</body> </html> </notes> <label text="SKP*"/> <bbox w="80.0" h="40.0" x="13411.5" y="1664.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s581_wca1_wca1_sa476"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> </notes> <label text="RBX1"/> <bbox w="80.0" h="40.0" x="13328.5" y="1707.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s582_wca1_wca1_sa477"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Beta-transducin repeat domain HUGO:BTRC HGNC:1144 ENTREZ:8945 UNIPROT:Q9Y297 GENECARDS:BTRC REACTOME:55056 KEGG:8945 ATLASONC:BTRCID451ch10q24 WIKI:BTRC F-box and WD repeat domain containing 11 BTRC2, BTRCP2, Fbw1b, Fbw11, Hos, KIAA0696 HUGO:FBXW11 HGNC:13607 ENTREZ:23291 UNIPROT:Q9UKB1 GENECARDS:FBXW11 REACTOME:55058 KEGG:23291 WIKI:FBXW11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 E3 Ligase subunit References_end Identifiers_begin: Beta-transducin repeat domain HUGO:BTRC HGNC:1144 ENTREZ:8945 UNIPROT:Q9Y297 GENECARDS:BTRC REACTOME:55056 KEGG:8945 ATLASONC:BTRCID451ch10q24 WIKI:BTRC F-box and WD repeat domain containing 11 BTRC2, BTRCP2, Fbw1b, Fbw11, Hos, KIAA0696 HUGO:FBXW11 HGNC:13607 ENTREZ:23291 UNIPROT:Q9UKB1 GENECARDS:FBXW11 REACTOME:55058 KEGG:23291 WIKI:FBXW11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 E3 Ligase subunit References_end</body> </html> Identifiers_begin: Beta-transducin repeat domain HUGO:BTRC HGNC:1144 ENTREZ:8945 UNIPROT:Q9Y297 GENECARDS:BTRC REACTOME:55056 KEGG:8945 ATLASONC:BTRCID451ch10q24 WIKI:BTRC F-box and WD repeat domain containing 11 BTRC2, BTRCP2, Fbw1b, Fbw11, Hos, KIAA0696 HUGO:FBXW11 HGNC:13607 ENTREZ:23291 UNIPROT:Q9UKB1 GENECARDS:FBXW11 REACTOME:55058 KEGG:23291 WIKI:FBXW11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 E3 Ligase subunit References_end</body> </html> </notes> <label text="βTRCP*"/> <bbox w="80.0" h="40.0" x="13411.5" y="1707.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s596_wca1_wca1_sa478"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:TLS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15688063 References_end</body> </html> </notes> <label text="RAD6*"/> <bbox w="80.0" h="40.0" x="13328.5" y="1750.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s598_wca1_wca1_sa480"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: neural precursor cell expressed developmentally down-regulated 8 HUGO:NEDD8 HGNC:7732 ENTREZ:4738 UNIPROT:Q15843 GENECARDS:NEDD8 KEGG:4738 ATLASONC:GC_NEDD8 WIKI:NEDD8 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:NER MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15688063 PMID:19576224 References_end</body> </html> </notes> <label text="NEDD8"/> <bbox w="80.0" h="40.0" x="13412.5" y="1748.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s584_wca1_wca1_sa481"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: G protein HUGO:GPS1 HGNC:4549 ENTREZ:2873 UNIPROT:Q13098 GENECARDS:GPS1 KEGG:2873 ATLASONC:GC_GPS1 WIKI:GPS1 HUGO:GPS2 HGNC:4550 ENTREZ:2874 UNIPROT:Q13227 GENECARDS:GPS2 KEGG:2874 WIKI:GPS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 References_end</body> </html> </notes> <label text="CSN1*"/> <bbox w="80.0" h="40.0" x="13328.5" y="1580.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s585_wca1_wca1_sa482"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) HUGO:COPS2 HGNC:30747 ENTREZ:9318 UNIPROT:P61201 GENECARDS:COPS2 KEGG:9318 ATLASONC:COPS2ID47362ch15q21 WIKI:COPS2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 References_end</body> </html> </notes> <label text="CSN2*"/> <bbox w="80.0" h="40.0" x="13328.5" y="1622.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s586_wca1_wca1_sa483"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis) HUGO:COPS3 HGNC:2239 ENTREZ:8533 UNIPROT:Q9UNS2 GENECARDS:COPS3 KEGG:8533 ATLASONC:GC_COPS3 WIKI:COPS3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 References_end</body> </html> </notes> <label text="CSN3*"/> <bbox w="80.0" h="40.0" x="13411.5" y="1580.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s587_wca1_wca1_sa484"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: COP9 constitutive photomorphogenic homolog subunit 4 (Arabidopsis) HUGO:COPS4 HGNC:16702 ENTREZ:51138 UNIPROT:Q9BT78 GENECARDS:COPS4 KEGG:51138 ATLASONC:GC_COPS4 WIKI:COPS4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 References_end</body> </html> </notes> <label text="CSN4*"/> <bbox w="80.0" h="40.0" x="13411.5" y="1622.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s588_wca1_wca1_sa485"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis) HUGO:COPS5 HGNC:2240 ENTREZ:10987 UNIPROT:Q92905 GENECARDS:COPS5 KEGG:10987 ATLASONC:GC_COPS5 WIKI:COPS5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 References_end</body> </html> </notes> <label text="CSN5*"/> <bbox w="80.0" h="40.0" x="13328.5" y="1496.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s589_wca1_wca1_sa486"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: COP9 constitutive photomorphogenic homolog subunit 6 (Arabidopsis) HUGO:COPS6 HGNC:21749 ENTREZ:10980 UNIPROT:Q7L5N1 GENECARDS:COPS6 KEGG:10980 ATLASONC:GC_COPS6 WIKI:COPS6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 References_end</body> </html> </notes> <label text="CSN6*"/> <bbox w="80.0" h="40.0" x="13328.5" y="1538.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s590_wca1_wca1_sa487"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: COP9 constitutive photomorphogenic homolog subunit 7A (Arabidopsis) HUGO:COPS7A HGNC:16758 ENTREZ:50813 UNIPROT:Q9UBW8 GENECARDS:COPS7A KEGG:50813 ATLASONC:GC_COPS7A WIKI:COPS7A COP9 constitutive photomorphogenic homolog subunit 7B (Arabidopsis) HUGO:COPS7B HGNC:16760 ENTREZ:64708 UNIPROT:Q9H9Q2 GENECARDS:COPS7B KEGG:64708 ATLASONC:GC_COPS7B WIKI:COPS7B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 References_end</body> </html> </notes> <label text="CSN7*"/> <bbox w="80.0" h="40.0" x="13411.5" y="1496.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s591_wca1_wca1_sa488"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) HUGO:COPS8 HGNC:24335 ENTREZ:10920 UNIPROT:Q99627 GENECARDS:COPS8 KEGG:10920 ATLASONC:GC_COPS8 WIKI:COPS8 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 References_end</body> </html> </notes> <label text="CSN8*"/> <bbox w="80.0" h="40.0" x="13411.5" y="1538.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s592_wca1_wca1_sa490"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ubiquitin specific peptidase 15 HUGO:USP15 HGNC:12613 ENTREZ:9958 UNIPROT:Q9Y4E8 GENECARDS:USP15 REACTOME:66846 KEGG:9958 ATLASONC:USP15ID44585ch12q14 WIKI:USP15 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19849719 PMID:19576224 References_end</body> </html> </notes> <label text="USP15"/> <bbox w="80.0" h="40.0" x="13328.5" y="1455.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s593_wca1_wca1_sa491"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein kinase D1 HUGO:PRKD1 HGNC:9407 ENTREZ:5587 UNIPROT:Q15139 GENECARDS:PRKD1 REACTOME:58211 KEGG:5587 ATLASONC:PRKCMID41860ch14q11 WIKI:PRKD1 protein kinase D2 HUGO:PRKD2 HGNC:17293 ENTREZ:25865 UNIPROT:Q9BZL6 GENECARDS:PRKD2 KEGG:25865 ATLASONC:GC_PRKD2 WIKI:PRKD2 protein kinase D3 HUGO:PRKD3 HGNC:9408 ENTREZ:23683 UNIPROT:O94806 GENECARDS:PRKD3 KEGG:23683 ATLASONC:GC_PRKD3 WIKI:PRKD3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19576224 PMID:19849719 References_end</body> </html> </notes> <label text="PKD*"/> <bbox w="80.0" h="40.0" x="13411.5" y="1455.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1299_wca1_wca1_sa634"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2β*"/> <bbox w="80.0" h="40.0" x="13331.053" y="1373.579"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1301_wca1_wca1_sa635"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 alpha 1 polypeptide HUGO:CSNK2A1 HGNC:2457 ENTREZ:1457 UNIPROT:P68400 GENECARDS:CSNK2A1 REACTOME:201673 KEGG:1457 ATLASONC:GC_CSNK2A1 WIKI:CSNK2A1 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 alpha 1 polypeptide HUGO:CSNK2A1 HGNC:2457 ENTREZ:1457 UNIPROT:P68400 GENECARDS:CSNK2A1 REACTOME:201673 KEGG:1457 ATLASONC:GC_CSNK2A1 WIKI:CSNK2A1 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2α*"/> <bbox w="80.0" h="40.0" x="13329.053" y="1414.2632"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1300_wca1_wca1_sa636"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 alpha prime polypeptide HUGO:CSNK2A2 HGNC:2459 ENTREZ:1459 UNIPROT:P19784 GENECARDS:CSNK2A2 REACTOME:57879 KEGG:1459 ATLASONC:GC_CSNK2A2 WIKI:CSNK2A2 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 alpha prime polypeptide HUGO:CSNK2A2 HGNC:2459 ENTREZ:1459 UNIPROT:P19784 GENECARDS:CSNK2A2 REACTOME:57879 KEGG:1459 ATLASONC:GC_CSNK2A2 WIKI:CSNK2A2 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2α'*"/> <bbox w="80.0" h="40.0" x="13411.053" y="1416.2632"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1726_wca1_wca1_csa67" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Cytoplasm Identifiers_end</body> </html> </notes> <label text="(V-ATPase)"/> <bbox w="313.0" h="68.0" x="13866.0" y="516.0"/> </glyph> <glyph class="complex" id="wca1_s_wca1_s1728_wca1_wca1_csa32" compartmentRef="wca1_wca1_c5_wca1_wca1_ca9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:_beta_-Arrestin2*:p120* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:52226983 PMID:21606194 PMID:20460648 s_wca1_re33(MAP:survival): PMID:19561074 PMID:20460648 PMID:19581931 PMID:21304492 PMID:21498506 AMER1 recruits axin s_wca1_re36(MAP:survival): PMID:20229235 PMID:18077588 PMID:20059949 PMID:20627573 ANNOTATION:GSK3 phosphorylates first LRP @ S1490 followed by CK1 in the repeat PPSP A ANNOTATION:CYCLINY/PFTK complex is able to phosphorylate s1490 on LRP6 which primes the receptor for CK1 phosphorylisation. The complex is present during G2/M phase and stimulates wnt signalling it has synergetic effect together with the wnt ligand WNT/b-catenin signalling oscillates durring cell cycle and peaks at G2/M References_end</body> </html> </notes> <label text="(Signalosome)"/> <bbox w="493.0" h="309.0" x="13841.5" y="647.5"/> <glyph class="macromolecule" id="wca1_wca1_s1729_wca1_wca1_sa184"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="53.0" h="123.0" x="13976.5" y="660.5"/> <glyph class="state variable" id="_75a01eb4-ce23-47ef-9f15-f7cfc6785c49"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14024.5" y="655.5"/> </glyph> <glyph class="state variable" id="_41f6d394-02ea-43fe-ac9b-1eccf2dc3f6c"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="13962.345" y="655.5"/> </glyph> <glyph class="state variable" id="_4458fe06-9c0f-43e4-a597-f51842fb5af6"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="14014.5" y="656.1604"/> </glyph> <glyph class="state variable" id="_217c05aa-e2eb-4324-af41-abd244f51539"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="14012.569" y="778.5"/> </glyph> <glyph class="state variable" id="_a42e8b86-b453-4ffc-81c3-14adda90a3c6"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="13961.659" y="778.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1730_wca1_wca1_sa185"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="14030.5" y="741.5"/> <glyph class="state variable" id="_dbfb00f0-7ab0-41de-a562-93a6013cb265"> <state value="" variable="S268"/> <bbox w="30.0" h="10.0" x="14015.992" y="736.5"/> </glyph> <glyph class="state variable" id="_69dffb5b-3a5f-4396-8fa4-c02ddfb20e52"> <state value="" variable="S269"/> <bbox w="30.0" h="10.0" x="14055.532" y="736.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1731_wca1_wca1_sa186"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="14028.5" y="781.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1732_wca1_wca1_sa187"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="13896.0" y="712.5"/> <glyph class="state variable" id="_e93b0d07-4e16-46dc-b1f1-73e2d3cff275"> <state value="P" variable="T1479"/> <bbox w="40.0" h="10.0" x="13876.0" y="732.4602"/> </glyph> <glyph class="state variable" id="_35368e50-445f-4682-9139-e3e5936d2940"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="13918.532" y="707.5"/> </glyph> <glyph class="state variable" id="_bc9449ce-efca-42d3-a487-e6e9686bcf20"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="13958.5" y="707.76843"/> </glyph> <glyph class="state variable" id="_0a6c0697-dd7f-4968-89c9-5267cba70288"> <state value="" variable="S1496"/> <bbox w="35.0" h="10.0" x="13957.882" y="757.5"/> </glyph> <glyph class="state variable" id="_1e938ad9-d9a6-43e6-b5cf-b1aaf608dcfb"> <state value="" variable="T1530"/> <bbox w="35.0" h="10.0" x="13917.6045" y="757.5"/> </glyph> <glyph class="state variable" id="_3a3c94e5-0285-45bf-b85a-40c07bd72259"> <state value="" variable="S1533"/> <bbox w="35.0" h="10.0" x="13878.74" y="757.5"/> </glyph> <glyph class="unit of information" id="_a6e51d27-2220-4431-8cf9-0823b543849a"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="13913.5" y="707.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1733_wca1_wca1_sa188"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="13896.0" y="756.5"/> <glyph class="unit of information" id="_11a35e7f-fc5d-4d8e-ba17-6222de2462c1"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="13913.5" y="751.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1734_wca1_wca1_sa190"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="13896.75" y="804.5"/> <glyph class="state variable" id="_f42daca8-4168-42ca-abde-a6b3e7e10390"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="13969.25" y="799.5"/> </glyph> <glyph class="state variable" id="_8567b46e-a4ea-42a3-bad4-926f5aa6e359"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13891.75" y="799.5"/> </glyph> <glyph class="state variable" id="_05ba13ae-0234-4303-9409-73c06db636b2"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="13961.132" y="839.5"/> </glyph> <glyph class="state variable" id="_6895dec9-0caa-4c4e-8928-d27107a8a30e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13891.75" y="799.5"/> </glyph> <glyph class="state variable" id="_03101d1e-8e76-42f9-8380-dfa26f5f4ae0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13971.75" y="799.5"/> </glyph> <glyph class="state variable" id="_d5739583-61c4-48e9-b191-da15b0a7b6d2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13971.384" y="799.5"/> </glyph> <glyph class="state variable" id="_144b37db-1b53-4eb3-867b-609f35b620c9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13971.75" y="839.5"/> </glyph> <glyph class="state variable" id="_4d7bf595-06d9-47e3-af0f-8c480513cd65"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="13881.75" y="839.2223"/> </glyph> <glyph class="state variable" id="_5f91dd3b-a938-4443-965d-c600a33e0ce4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13891.75" y="839.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1729_wca1_wca1_sa192"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="53.0" h="123.0" x="14192.5" y="662.5"/> <glyph class="state variable" id="_b9b959d8-0dc7-413e-a193-3e1e9cd64257"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14240.5" y="657.5"/> </glyph> <glyph class="state variable" id="_43419943-22f8-4c67-bc32-0c93d7f9be58"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="14178.345" y="657.5"/> </glyph> <glyph class="state variable" id="_da02ca10-fb8a-4c5e-9873-8712df1d4941"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="14230.5" y="658.1604"/> </glyph> <glyph class="state variable" id="_884016e1-168a-478f-a975-4af3b40f7eae"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="14228.569" y="780.5"/> </glyph> <glyph class="state variable" id="_b5564aa0-99a2-430b-b08b-abd23f12a558"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="14177.659" y="780.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1730_wca1_wca1_sa193"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="14246.5" y="743.5"/> <glyph class="state variable" id="_47a92e18-87ca-443e-8659-3d1f66cacb31"> <state value="" variable="S268"/> <bbox w="30.0" h="10.0" x="14231.992" y="738.5"/> </glyph> <glyph class="state variable" id="_57863e56-0b0f-475d-b6a1-057886247b3a"> <state value="" variable="S269"/> <bbox w="30.0" h="10.0" x="14271.532" y="738.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1731_wca1_wca1_sa194"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="14244.5" y="783.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1732_wca1_wca1_sa195"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="14112.0" y="714.5"/> <glyph class="state variable" id="_2aaa759c-0fad-47a9-9dee-950b89acbd5d"> <state value="P" variable="T1479"/> <bbox w="40.0" h="10.0" x="14092.0" y="734.4602"/> </glyph> <glyph class="state variable" id="_34b42f6c-58aa-4ee6-9ad6-6cb299b22edb"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="14134.532" y="709.5"/> </glyph> <glyph class="state variable" id="_87e29064-0ae5-45ec-aff8-598a437c7768"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="14174.5" y="709.76843"/> </glyph> <glyph class="state variable" id="_96d16190-6716-4657-b768-1bbd064bbc99"> <state value="" variable="S1496"/> <bbox w="35.0" h="10.0" x="14173.882" y="759.5"/> </glyph> <glyph class="state variable" id="_2698a98b-df07-4517-b563-67cf94025ec0"> <state value="" variable="T1530"/> <bbox w="35.0" h="10.0" x="14133.6045" y="759.5"/> </glyph> <glyph class="state variable" id="_7e14ef99-c8db-4cc9-b1f0-1b609b4bd0d2"> <state value="" variable="S1533"/> <bbox w="35.0" h="10.0" x="14094.74" y="759.5"/> </glyph> <glyph class="unit of information" id="_5a4b79d4-5616-4470-beed-c991e3ff67f5"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14129.5" y="709.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1733_wca1_wca1_sa196"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="14112.0" y="758.5"/> <glyph class="unit of information" id="_9f339c5d-938c-447f-b30a-1f13520c0e6d"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14129.5" y="753.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1734_wca1_wca1_sa198"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="14112.75" y="806.5"/> <glyph class="state variable" id="_77f73ca6-9cb4-46b5-98e6-c784651664c1"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14185.25" y="801.5"/> </glyph> <glyph class="state variable" id="_9e631ec1-2d12-4ef4-9a16-2823f12e1bc0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14107.75" y="801.5"/> </glyph> <glyph class="state variable" id="_cc20edda-17eb-4f5e-bc15-55cf300d1280"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="14177.132" y="841.5"/> </glyph> <glyph class="state variable" id="_49581837-c7b5-44d0-bb9f-2d4c901a8d51"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14107.75" y="801.5"/> </glyph> <glyph class="state variable" id="_504b03a2-aab9-49bf-a374-d904b9958a01"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14187.75" y="801.5"/> </glyph> <glyph class="state variable" id="_ecf1754c-258f-485b-844a-bda4c92e639e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14187.384" y="801.5"/> </glyph> <glyph class="state variable" id="_b009b9a3-c7cd-48e9-9ab0-c4756d1f386c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14187.75" y="841.5"/> </glyph> <glyph class="state variable" id="_ce1aeeeb-b986-4916-85b4-17d8c0d1076e"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="14097.75" y="841.2223"/> </glyph> <glyph class="state variable" id="_0f7441a2-7ab4-43b8-a92d-890492993491"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14107.75" y="841.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s298_wca1_wca1_sa199"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein) alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 (Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 guanine nucleotide binding protein (G protein) alpha activating activity polypeptide olfactory type HUGO:GNAL HGNC:4388 ENTREZ:2774 UNIPROT:P38405 GENECARDS:GNAL REACTOME:55364 ATLASONC:GC_GNAL WIKI:GNAL guanine nucleotide binding protein (G protein) alpha activating activity polypeptide O HUGO:GNAO1 HGNC:4389 ENTREZ:2775 UNIPROT:P09471 GENECARDS:GNAO1 REACTOME:55350 KEGG:2775 ATLASONC:GC_GNAO1 WIKI:GNAO1 guanine nucleotide binding protein (G protein) q polypeptide HUGO:GNAQ HGNC:4390 ENTREZ:2776 UNIPROT:P50148 GENECARDS:GNAQ REACTOME:55454 KEGG:2776 ATLASONC:GNAQID43280ch9q21 WIKI:GNAQ Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21640127 References_end</body> </html> </notes> <label text="Gαo*"/> <bbox w="40.0" h="20.0" x="13982.5" y="916.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s340_wca1_wca1_sa218"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="13899.0" y="859.0"/> <glyph class="state variable" id="_98ae578f-c940-41c3-9042-b759f8c3f604"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="13886.992" y="854.0"/> </glyph> <glyph class="state variable" id="_e1fff53a-c91f-47ab-bf30-8a8c0a19b496"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="13926.532" y="854.0"/> </glyph> <glyph class="state variable" id="_eb2fb161-76cf-4e84-8664-53055461b82c"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="13964.0" y="854.2148"/> </glyph> <glyph class="state variable" id="_c06383be-05b1-411c-bec6-3594a62ecf13"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="13963.382" y="894.0"/> </glyph> <glyph class="state variable" id="_a4911127-9ea7-41db-9503-7bcbf012aeec"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="13923.904" y="894.0"/> </glyph> <glyph class="state variable" id="_d47f481e-b924-49ae-82a6-a1c42187b266"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="13884.0" y="893.7223"/> </glyph> <glyph class="state variable" id="_2b10ea11-0f54-4f39-8294-810a1fd544ab"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="13926.404" y="894.0"/> </glyph> <glyph class="state variable" id="_5210695f-88f0-4f19-8f52-99d2caf6056d"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="13965.882" y="894.0"/> </glyph> <glyph class="state variable" id="_8d1ce2e3-ea9b-4abb-b668-278a7404ac69"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="13971.5" y="854.2148"/> </glyph> <glyph class="state variable" id="_8fa7b775-93dc-47c4-96cc-a011113aa179"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13886.5" y="893.7223"/> </glyph> <glyph class="state variable" id="_ffc3db15-e518-4455-9202-7c388741bc1f"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="13891.992" y="854.0"/> </glyph> <glyph class="state variable" id="_d2b1dafc-6f52-4b8d-85d6-ffa64a408341"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13894.0" y="854.0"/> </glyph> <glyph class="state variable" id="_a5e483af-769e-474d-b81d-eb719426fd60"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13974.0" y="854.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s341_wca1_wca1_sa220"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="13984.0" y="859.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s342_wca1_wca1_sa223"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="13898.5" y="907.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1735_wca1_wca1_sa409"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1γ*"/> <bbox w="80.0" h="40.0" x="14030.5" y="697.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1735_wca1_wca1_sa410"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1γ*"/> <bbox w="80.0" h="40.0" x="14246.5" y="701.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1736_wca1_wca1_sa518"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="13977.25" y="827.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1737_wca1_wca1_sa519"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="14018.25" y="827.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1736_wca1_wca1_sa520"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="14197.25" y="831.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1737_wca1_wca1_sa521"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="14238.25" y="831.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1738_wca1_wca1_sa557"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="14065.5" y="859.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1738_wca1_wca1_sa558"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="14147.5" y="858.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1739_wca1_wca1_sa584"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="14030.5" y="656.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1739_wca1_wca1_sa586"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="14247.0" y="659.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1740_wca1_wca1_sa609"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="13914.0" y="696.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1740_wca1_wca1_sa621"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="14134.0" y="696.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1395_wca1_wca1_sa656"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end</body> </html> </notes> <label text="PRR*"/> <bbox w="50.0" h="40.0" x="13843.182" y="768.2727"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1741_wca1_wca1_csa36" compartmentRef="wca1_wca1_c5_wca1_wca1_ca9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:_beta_-Arrestin2*:p120* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:52226983 PMID:21606194 PMID:20460648 s_wca1_re36(MAP:survival): PMID:20229235 PMID:18077588 PMID:20059949 PMID:20627573 ANNOTATION:GSK3 phosphorylates first LRP @ S1490 followed by CK1 in the repeat PPSP A ANNOTATION:CYCLINY/PFTK complex is able to phosphorylate s1490 on LRP6 which primes the receptor for CK1 phosphorylisation. The complex is present during G2/M phase and stimulates wnt signalling it has synergetic effect together with the wnt ligand WNT/b-catenin signalling oscillates durring cell cycle and peaks at G2/M s_wca1_re37(MAP:survival): PMID:20229235 PMID:18077588 PMID:21304492 PMID:21498506 Phosphorylation of the repeat PPSP A allows recruitment of additional GSK/AXIN which phosphorylates LRP5/6 on other PPSP repeats resulting of sequestering of GSK3 and AXIN away from the destruction complex AMER1 recruits axin and GSk3 s_wca1_re38(MAP:survival): PMID:20229235 PMID:18077588 ANNOTATION:GSK3 phosphorylates first @ S1490 followed by CK1 in the repeat PPSP A References_end</body> </html> </notes> <label text="(Signalosome)"/> <bbox w="490.0" h="305.0" x="14361.5" y="647.5"/> <glyph class="macromolecule" id="wca1_wca1_s1742_wca1_wca1_sa230"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="53.0" h="123.0" x="14487.5" y="660.5"/> <glyph class="state variable" id="_cf044737-c838-4580-911d-bf98fed45118"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14535.5" y="655.5"/> </glyph> <glyph class="state variable" id="_c1f0118a-11a4-4543-8a3b-325096c1936f"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="14473.345" y="655.5"/> </glyph> <glyph class="state variable" id="_d2661802-ce98-4e55-82ec-36648b62f4a2"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="14525.5" y="656.1604"/> </glyph> <glyph class="state variable" id="_ddd19916-5e02-4f0b-acde-9c7cf0a034ba"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="14523.569" y="778.5"/> </glyph> <glyph class="state variable" id="_515d8cad-d2c2-4229-8d8a-1a3562ab500a"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="14472.659" y="778.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1743_wca1_wca1_sa231"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="14541.5" y="741.5"/> <glyph class="state variable" id="_459fe40c-3c1d-40ce-a71d-ee701d71ba58"> <state value="" variable="S268"/> <bbox w="30.0" h="10.0" x="14526.992" y="736.5"/> </glyph> <glyph class="state variable" id="_cf95074c-b440-47b9-810e-83b926f44403"> <state value="" variable="S269"/> <bbox w="30.0" h="10.0" x="14566.532" y="736.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1744_wca1_wca1_sa232"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="14539.5" y="781.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1745_wca1_wca1_sa233"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="14407.0" y="712.5"/> <glyph class="state variable" id="_2cb6e855-d5ce-42fa-931f-ffcba696fe01"> <state value="P" variable="T1479"/> <bbox w="40.0" h="10.0" x="14387.0" y="732.4602"/> </glyph> <glyph class="state variable" id="_600c6c09-c58c-403b-b23a-65466e1a58f7"> <state value="P" variable="S1490"/> <bbox w="40.0" h="10.0" x="14427.032" y="707.5"/> </glyph> <glyph class="state variable" id="_4aed9e42-70d7-480a-8588-a5097dee77c3"> <state value="P" variable="T1493"/> <bbox w="40.0" h="10.0" x="14467.0" y="707.76843"/> </glyph> <glyph class="state variable" id="_05ecf87b-8888-4ea4-820b-ac04780d9d45"> <state value="P" variable="S1496"/> <bbox w="40.0" h="10.0" x="14466.382" y="757.5"/> </glyph> <glyph class="state variable" id="_8ea16500-eaa6-4351-8b2e-b46256733aa8"> <state value="" variable="T1530"/> <bbox w="35.0" h="10.0" x="14428.6045" y="757.5"/> </glyph> <glyph class="state variable" id="_2075187e-ba32-413f-aded-9342bdc080c4"> <state value="" variable="S1533"/> <bbox w="35.0" h="10.0" x="14389.74" y="757.5"/> </glyph> <glyph class="unit of information" id="_414bde68-a64e-4673-ba62-8e55eea82c5b"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14424.5" y="707.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1746_wca1_wca1_sa234"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="14407.0" y="756.5"/> <glyph class="unit of information" id="_5d31340c-800c-4985-8815-05be6539d2ae"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14424.5" y="751.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1747_wca1_wca1_sa236"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="14407.75" y="804.5"/> <glyph class="state variable" id="_498ed976-2ae3-47bd-be79-335aaaf459d5"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14480.25" y="799.5"/> </glyph> <glyph class="state variable" id="_990d13f4-4a54-4dc0-b11c-febd2887ad7f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14402.75" y="799.5"/> </glyph> <glyph class="state variable" id="_bc82569b-ab12-4f6f-8c79-43debfe529e3"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="14472.132" y="839.5"/> </glyph> <glyph class="state variable" id="_3e904cd9-0308-483e-a7d0-7818ad6678ce"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14402.75" y="799.5"/> </glyph> <glyph class="state variable" id="_bbc7fc3d-ff32-44c7-beb6-bbeb53d8e5d1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14482.75" y="799.5"/> </glyph> <glyph class="state variable" id="_2689712e-d96e-463f-b0c1-d13102573f12"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14482.384" y="799.5"/> </glyph> <glyph class="state variable" id="_6b4a9521-ad0e-4fae-a042-e7e32f75bd36"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14482.75" y="839.5"/> </glyph> <glyph class="state variable" id="_80647001-f253-40f7-a439-877eebaeb643"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="14392.75" y="839.2223"/> </glyph> <glyph class="state variable" id="_ebdcc405-395d-4734-94c8-34843111925a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14402.75" y="839.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1742_wca1_wca1_sa238"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="53.0" h="123.0" x="14703.5" y="662.5"/> <glyph class="state variable" id="_a5a8cdc1-c3ed-4e70-88b3-9c86b98348b9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14751.5" y="657.5"/> </glyph> <glyph class="state variable" id="_5e76d346-8783-428f-bc49-5c922d2e06d5"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="14689.345" y="657.5"/> </glyph> <glyph class="state variable" id="_b946fdfc-f614-404d-a1f6-cb8fc43f0688"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="14741.5" y="658.1604"/> </glyph> <glyph class="state variable" id="_0c49b569-a9f3-4ffd-9d91-d4be463aea90"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="14739.569" y="780.5"/> </glyph> <glyph class="state variable" id="_8f3d426a-1d64-45e1-9ad4-af21ccd62335"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="14688.659" y="780.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1743_wca1_wca1_sa239"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="14757.5" y="743.5"/> <glyph class="state variable" id="_fc141d11-fd17-4c4b-9684-5badcb321a6d"> <state value="" variable="S268"/> <bbox w="30.0" h="10.0" x="14742.992" y="738.5"/> </glyph> <glyph class="state variable" id="_9e877989-6a56-41af-9ed5-90a67bbc1e72"> <state value="" variable="S269"/> <bbox w="30.0" h="10.0" x="14782.532" y="738.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1744_wca1_wca1_sa240"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="14755.5" y="783.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1745_wca1_wca1_sa241"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="14623.0" y="714.5"/> <glyph class="state variable" id="_add320bc-1fd6-45bd-9c19-8f689fcbbf9e"> <state value="P" variable="T1479"/> <bbox w="40.0" h="10.0" x="14603.0" y="734.4602"/> </glyph> <glyph class="state variable" id="_800fbde1-1766-452d-90e5-2e0e7b39ac8c"> <state value="P" variable="S1490"/> <bbox w="40.0" h="10.0" x="14643.032" y="709.5"/> </glyph> <glyph class="state variable" id="_e707a6e4-1d2f-47da-86c0-4956b94e449b"> <state value="P" variable="T1493"/> <bbox w="40.0" h="10.0" x="14683.0" y="709.76843"/> </glyph> <glyph class="state variable" id="_d3dd6ef4-ed64-4493-82fa-0ecf61a449a2"> <state value="P" variable="S1496"/> <bbox w="40.0" h="10.0" x="14682.382" y="759.5"/> </glyph> <glyph class="state variable" id="_04d07912-b0fd-4af5-a1f0-78ded1255e20"> <state value="" variable="T1530"/> <bbox w="35.0" h="10.0" x="14644.6045" y="759.5"/> </glyph> <glyph class="state variable" id="_5b203f7d-d6ef-476b-8ad8-868a7ea24505"> <state value="" variable="S1533"/> <bbox w="35.0" h="10.0" x="14605.74" y="759.5"/> </glyph> <glyph class="unit of information" id="_e0b579c3-35d1-4f16-bbc7-a99965b33192"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14640.5" y="709.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1746_wca1_wca1_sa242"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="14623.0" y="758.5"/> <glyph class="unit of information" id="_c4dea03d-5c5a-46f3-aedd-be5d6c4e4121"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14640.5" y="753.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1747_wca1_wca1_sa244"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="14623.75" y="806.5"/> <glyph class="state variable" id="_b0cadd6c-6b7a-4262-9f4e-264f0053a448"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14696.25" y="801.5"/> </glyph> <glyph class="state variable" id="_c3965048-7711-4eab-8754-83a14704de9e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14618.75" y="801.5"/> </glyph> <glyph class="state variable" id="_c9a84968-0f4e-45a1-abec-13328a41c449"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="14688.132" y="841.5"/> </glyph> <glyph class="state variable" id="_9ec61c03-27ee-46fb-8c67-711b4213199c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14618.75" y="801.5"/> </glyph> <glyph class="state variable" id="_49c49ed1-e2d0-4dc7-af1e-ab7a1649b339"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14698.75" y="801.5"/> </glyph> <glyph class="state variable" id="_e446e534-a6b8-40a3-ba90-79dab356b70d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14698.384" y="801.5"/> </glyph> <glyph class="state variable" id="_e3e0582e-33e1-48c8-ae71-55d57d0f53ec"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14698.75" y="841.5"/> </glyph> <glyph class="state variable" id="_18f8b45c-b542-478f-9771-1b3953817a7f"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="14608.75" y="841.2223"/> </glyph> <glyph class="state variable" id="_eb719ae4-ef67-4cde-b444-51e29f8d4a03"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14618.75" y="841.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1472_wca1_wca1_sa245"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein) alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 (Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 guanine nucleotide binding protein (G protein) alpha activating activity polypeptide olfactory type HUGO:GNAL HGNC:4388 ENTREZ:2774 UNIPROT:P38405 GENECARDS:GNAL REACTOME:55364 ATLASONC:GC_GNAL WIKI:GNAL guanine nucleotide binding protein (G protein) alpha activating activity polypeptide O HUGO:GNAO1 HGNC:4389 ENTREZ:2775 UNIPROT:P09471 GENECARDS:GNAO1 REACTOME:55350 KEGG:2775 ATLASONC:GC_GNAO1 WIKI:GNAO1 guanine nucleotide binding protein (G protein) q polypeptide HUGO:GNAQ HGNC:4390 ENTREZ:2776 UNIPROT:P50148 GENECARDS:GNAQ REACTOME:55454 KEGG:2776 ATLASONC:GNAQID43280ch9q21 WIKI:GNAQ Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21640127 References_end</body> </html> </notes> <label text="Gαo*"/> <bbox w="40.0" h="20.0" x="14493.5" y="918.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1473_wca1_wca1_sa246"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="14410.0" y="859.0"/> <glyph class="state variable" id="_e24d60c9-5475-4167-a0a2-6a4c50ee7fb7"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="14397.992" y="854.0"/> </glyph> <glyph class="state variable" id="_56e9797a-366a-4c26-8e29-d0ac42ab3711"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="14437.532" y="854.0"/> </glyph> <glyph class="state variable" id="_d143b342-e45c-44fc-b377-9465bbb9f852"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="14475.0" y="854.2148"/> </glyph> <glyph class="state variable" id="_b446e78e-7cb3-43c9-865f-558cf110fe6b"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="14474.382" y="894.0"/> </glyph> <glyph class="state variable" id="_cffadbee-e1f6-401e-b4ea-3afb7edbf42c"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="14434.904" y="894.0"/> </glyph> <glyph class="state variable" id="_f825e18e-5ff6-4a8e-b693-1f05b60704d8"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="14395.0" y="893.7223"/> </glyph> <glyph class="state variable" id="_5a7ad7e6-f2dc-41bd-8a25-c5afc1bd6217"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="14437.404" y="894.0"/> </glyph> <glyph class="state variable" id="_d1390e85-4d0e-4db4-ac04-bce1ecc92f73"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="14476.882" y="894.0"/> </glyph> <glyph class="state variable" id="_b305505c-fce4-4425-9c4f-9939d71dd196"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14482.5" y="854.2148"/> </glyph> <glyph class="state variable" id="_aaa7ee73-e0f1-49a7-9ec4-112aeca617e9"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="14397.5" y="893.7223"/> </glyph> <glyph class="state variable" id="_9646e7e9-3510-4d14-997a-cd08e24389c4"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14402.992" y="854.0"/> </glyph> <glyph class="state variable" id="_01a94b0e-0919-4992-93e7-7cfd5b8f55c9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14405.0" y="854.0"/> </glyph> <glyph class="state variable" id="_15e95c7e-ae30-4e4f-a5d3-81847167b7e4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14485.0" y="854.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1474_wca1_wca1_sa247"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="14495.0" y="859.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1475_wca1_wca1_sa248"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="14409.5" y="907.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1748_wca1_wca1_sa414"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1γ*"/> <bbox w="80.0" h="40.0" x="14755.5" y="699.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1748_wca1_wca1_sa415"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1γ*"/> <bbox w="80.0" h="40.0" x="14539.5" y="697.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1749_wca1_wca1_sa514"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="14707.25" y="827.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1750_wca1_wca1_sa515"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="14748.25" y="827.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1749_wca1_wca1_sa516"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="14494.25" y="822.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1750_wca1_wca1_sa517"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="14535.25" y="822.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1751_wca1_wca1_sa559"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="14657.5" y="858.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1751_wca1_wca1_sa560"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="14576.5" y="858.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1752_wca1_wca1_sa585"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="14539.5" y="656.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1752_wca1_wca1_sa587"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="14754.5" y="659.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1753_wca1_wca1_sa606"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="14424.0" y="696.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1753_wca1_wca1_sa607"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="14644.0" y="696.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1482_wca1_wca1_sa657"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end</body> </html> </notes> <label text="PRR*"/> <bbox w="50.0" h="40.0" x="14364.182" y="785.1818"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1754_wca1_wca1_csa38" compartmentRef="wca1_wca1_c5_wca1_wca1_ca9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:APC:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:_beta_-Arrestin2*:p120* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:52226983 PMID:21606194 PMID:20460648 s_wca1_re38(MAP:survival): PMID:20229235 PMID:18077588 ANNOTATION:GSK3 phosphorylates first @ S1490 followed by CK1 in the repeat PPSP A References_end</body> </html> </notes> <label text="(Signalosome)"/> <bbox w="480.0" h="345.0" x="13837.5" y="1001.0"/> <glyph class="macromolecule" id="wca1_wca1_s1755_wca1_wca1_sa605"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="13897.0" y="1048.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1756_wca1_wca1_sa589"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="14011.0" y="1010.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1756_wca1_wca1_sa588"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="14229.5" y="1015.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1757_wca1_wca1_sa562"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="14132.5" y="1289.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1757_wca1_wca1_sa561"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="13967.5" y="1287.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1758_wca1_wca1_sa509"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="14003.25" y="1178.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1759_wca1_wca1_sa508"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="13962.25" y="1178.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1758_wca1_wca1_sa507"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="14219.25" y="1179.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1759_wca1_wca1_sa506"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="14178.25" y="1179.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1760_wca1_wca1_sa419"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1γ*"/> <bbox w="80.0" h="40.0" x="14010.5" y="1052.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1760_wca1_wca1_sa418"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1γ*"/> <bbox w="80.0" h="40.0" x="14229.5" y="1056.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1761_wca1_wca1_sa299"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="14218.0" y="1214.0"/> <glyph class="state variable" id="_d1f9e53f-5a3f-49bd-9d24-dd30d331eaa2"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="14205.992" y="1209.0"/> </glyph> <glyph class="state variable" id="_f9a872cc-ec14-47fd-9562-d194110b6bbf"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="14245.532" y="1209.0"/> </glyph> <glyph class="state variable" id="_88f59d4d-4ef9-4c44-9169-bc18b0617b4c"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="14283.0" y="1209.2147"/> </glyph> <glyph class="state variable" id="_945d6dbd-9be2-4ae0-9d7d-cba8b7474ae7"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="14282.382" y="1249.0"/> </glyph> <glyph class="state variable" id="_fc0c5c40-a650-47fd-bf6f-dc5c8935c28a"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="14242.904" y="1249.0"/> </glyph> <glyph class="state variable" id="_28f1103a-e473-4981-addb-d27acff61a3d"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="14203.0" y="1248.7223"/> </glyph> <glyph class="state variable" id="_6c83d418-34a2-409e-b979-d241fb6459c3"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="14245.404" y="1249.0"/> </glyph> <glyph class="state variable" id="_e2554261-8ba9-4260-a9b4-97891d9d58d4"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="14284.882" y="1249.0"/> </glyph> <glyph class="state variable" id="_b0931f39-9777-4880-85b9-af15880e7b24"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14290.5" y="1209.2147"/> </glyph> <glyph class="state variable" id="_df797f40-ef0a-4151-bbcd-c7e7a6766553"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="14205.5" y="1248.7223"/> </glyph> <glyph class="state variable" id="_057fe631-6592-4fac-92f2-deb3300d585d"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14210.992" y="1209.0"/> </glyph> <glyph class="state variable" id="_04b42978-312d-4fee-9e28-d79de56656fd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14213.0" y="1209.0"/> </glyph> <glyph class="state variable" id="_cc6ab293-b973-44f5-b4a1-db16eaff04a0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14293.0" y="1209.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1762_wca1_wca1_sa298"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="14216.5" y="1258.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1763_wca1_wca1_sa296"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="14137.0" y="1214.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1762_wca1_wca1_sa294"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="14049.5" y="1257.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1761_wca1_wca1_sa293"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="14053.0" y="1214.0"/> <glyph class="state variable" id="_5db44bf0-ad50-4065-8153-bd0744d10898"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="14040.992" y="1209.0"/> </glyph> <glyph class="state variable" id="_9916582c-8c0a-4b77-9406-49b10b25e625"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="14080.532" y="1209.0"/> </glyph> <glyph class="state variable" id="_7440caaa-ed40-4954-bd9e-f21aa12fab83"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="14118.0" y="1209.2147"/> </glyph> <glyph class="state variable" id="_f46909a1-fe30-4f12-9028-55c2ec6b71f4"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="14117.382" y="1249.0"/> </glyph> <glyph class="state variable" id="_c402ac29-b15f-426d-b804-c8c1a9a2f5aa"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="14077.904" y="1249.0"/> </glyph> <glyph class="state variable" id="_7ce29036-11f7-4cc5-85de-9f9f4c9a51f9"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="14038.0" y="1248.7223"/> </glyph> <glyph class="state variable" id="_1e2d08c3-bec0-4cfe-98c0-cfa3b7cb8c14"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="14080.404" y="1249.0"/> </glyph> <glyph class="state variable" id="_6e5dd847-ad43-4e85-a339-e8a6d70285cb"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="14119.882" y="1249.0"/> </glyph> <glyph class="state variable" id="_46f3b080-bbcd-4198-a3f3-e2d1d8620596"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14125.5" y="1209.2147"/> </glyph> <glyph class="state variable" id="_e785bd4b-e5d9-406c-a995-f424c08d4080"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="14040.5" y="1248.7223"/> </glyph> <glyph class="state variable" id="_a9c86e20-e39d-4984-9863-5863a613ab3a"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14045.992" y="1209.0"/> </glyph> <glyph class="state variable" id="_4878b22a-9095-40ad-be2c-b611bb8c6776"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14048.0" y="1209.0"/> </glyph> <glyph class="state variable" id="_8d3ce500-f12b-4d18-8b64-f9d6a6ae98a2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14128.0" y="1209.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1764_wca1_wca1_sa292"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="14095.0" y="1068.0"/> <glyph class="state variable" id="_6fc166b0-443a-4f05-bc32-da8c7adf7218"> <state value="P" variable="T1479"/> <bbox w="40.0" h="10.0" x="14075.0" y="1087.9602"/> </glyph> <glyph class="state variable" id="_ba36456b-fc6f-4f85-b8a0-f39e092fabe1"> <state value="P" variable="S1490"/> <bbox w="40.0" h="10.0" x="14115.032" y="1063.0"/> </glyph> <glyph class="state variable" id="_f4ce733c-1a6f-4584-8955-798c1664a1fc"> <state value="P" variable="T1493"/> <bbox w="40.0" h="10.0" x="14155.0" y="1063.2684"/> </glyph> <glyph class="state variable" id="_d6c201fb-c3f0-4565-a312-ff98902d3126"> <state value="P" variable="S1496"/> <bbox w="40.0" h="10.0" x="14154.382" y="1113.0"/> </glyph> <glyph class="state variable" id="_f900c27c-9666-4262-b3b7-8766a00cac5e"> <state value="" variable="T1530"/> <bbox w="35.0" h="10.0" x="14116.6045" y="1113.0"/> </glyph> <glyph class="state variable" id="_8c0c9edc-6370-4859-8784-551d7cd32d9f"> <state value="" variable="S1533"/> <bbox w="35.0" h="10.0" x="14077.74" y="1113.0"/> </glyph> <glyph class="unit of information" id="_1a0ed99f-ce84-46b5-aad7-a31881daf260"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14112.5" y="1063.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1764_wca1_wca1_sa291"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="13879.0" y="1066.0"/> <glyph class="state variable" id="_21431890-7663-4071-a014-c1e6f14da0e4"> <state value="P" variable="T1479"/> <bbox w="40.0" h="10.0" x="13859.0" y="1085.9602"/> </glyph> <glyph class="state variable" id="_05647aeb-da07-4090-97dc-fac5898b8a8c"> <state value="P" variable="S1490"/> <bbox w="40.0" h="10.0" x="13899.032" y="1061.0"/> </glyph> <glyph class="state variable" id="_4f451ef6-a612-40bd-a26e-eefa6d22020b"> <state value="P" variable="T1493"/> <bbox w="40.0" h="10.0" x="13939.0" y="1061.2684"/> </glyph> <glyph class="state variable" id="_22a2636f-b0cd-4e04-9788-5026c405c95f"> <state value="P" variable="S1496"/> <bbox w="40.0" h="10.0" x="13938.382" y="1111.0"/> </glyph> <glyph class="state variable" id="_b769eddd-70a7-479c-ab22-2b2e650229f0"> <state value="" variable="T1530"/> <bbox w="35.0" h="10.0" x="13900.6045" y="1111.0"/> </glyph> <glyph class="state variable" id="_747d9c62-91f6-400a-9a3a-b15c24b4f3da"> <state value="" variable="S1533"/> <bbox w="35.0" h="10.0" x="13861.74" y="1111.0"/> </glyph> <glyph class="unit of information" id="_ce1933d9-bb18-4295-b56d-92ef60ae12d6"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="13896.5" y="1061.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1762_wca1_wca1_sa288"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="13881.5" y="1260.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1763_wca1_wca1_sa287"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="13967.0" y="1212.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1761_wca1_wca1_sa286"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="13882.0" y="1212.5"/> <glyph class="state variable" id="_9e80efde-614a-4bf4-b16c-11b7e6d36fad"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="13869.992" y="1207.5"/> </glyph> <glyph class="state variable" id="_953c9c75-bd11-45c7-98cd-1aa5a0fc7383"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="13909.532" y="1207.5"/> </glyph> <glyph class="state variable" id="_299e36c1-3caf-4ed3-9416-5d3d66e459aa"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="13947.0" y="1207.7147"/> </glyph> <glyph class="state variable" id="_3a16c2b2-d7fe-493d-a184-629c0934021a"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="13946.382" y="1247.5"/> </glyph> <glyph class="state variable" id="_01438747-bada-49d3-902f-5add2bf91a28"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="13906.904" y="1247.5"/> </glyph> <glyph class="state variable" id="_8d5733f9-7e6a-42e9-8445-bcbb6ddbef00"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="13867.0" y="1247.2223"/> </glyph> <glyph class="state variable" id="_68f6236d-db24-4677-a16f-de11226cc4f4"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="13909.404" y="1247.5"/> </glyph> <glyph class="state variable" id="_604b797e-bb61-4742-8a5c-92b2006ba3bb"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="13948.882" y="1247.5"/> </glyph> <glyph class="state variable" id="_a33645db-ec80-4b4f-a60e-c4550db06501"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="13954.5" y="1207.7147"/> </glyph> <glyph class="state variable" id="_d346729c-b867-4b4b-a9b4-6f2a95fc80df"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13869.5" y="1247.2223"/> </glyph> <glyph class="state variable" id="_8ce35fe4-0bce-4cf3-af71-6bc30374eea7"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="13874.992" y="1207.5"/> </glyph> <glyph class="state variable" id="_a3c81437-791e-46f1-9cb1-337612242463"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13877.0" y="1207.5"/> </glyph> <glyph class="state variable" id="_f71b5ab9-8e5b-4382-8a98-9bf19541cdeb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13957.0" y="1207.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1765_wca1_wca1_sa285"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein) alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 (Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 guanine nucleotide binding protein (G protein) alpha activating activity polypeptide olfactory type HUGO:GNAL HGNC:4388 ENTREZ:2774 UNIPROT:P38405 GENECARDS:GNAL REACTOME:55364 ATLASONC:GC_GNAL WIKI:GNAL guanine nucleotide binding protein (G protein) alpha activating activity polypeptide O HUGO:GNAO1 HGNC:4389 ENTREZ:2775 UNIPROT:P09471 GENECARDS:GNAO1 REACTOME:55350 KEGG:2775 ATLASONC:GC_GNAO1 WIKI:GNAO1 guanine nucleotide binding protein (G protein) q polypeptide HUGO:GNAQ HGNC:4390 ENTREZ:2776 UNIPROT:P50148 GENECARDS:GNAQ REACTOME:55454 KEGG:2776 ATLASONC:GNAQID43280ch9q21 WIKI:GNAQ Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21640127 References_end</body> </html> </notes> <label text="Gαo*"/> <bbox w="40.0" h="20.0" x="14132.5" y="1263.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1766_wca1_wca1_sa284"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="14095.75" y="1160.0"/> <glyph class="state variable" id="_80ebbbb4-8a03-4611-9104-26375122cb62"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14168.25" y="1155.0"/> </glyph> <glyph class="state variable" id="_7b236785-9db9-4502-b92a-d7de89a0c8f4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14090.75" y="1155.0"/> </glyph> <glyph class="state variable" id="_34281147-c505-454d-a41d-592c3ac847da"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="14160.132" y="1195.0"/> </glyph> <glyph class="state variable" id="_dc877ecc-b6bb-4194-9494-4230b239d036"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14090.75" y="1155.0"/> </glyph> <glyph class="state variable" id="_8f750df8-320d-48cb-8ea4-a1877e790f51"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14170.75" y="1155.0"/> </glyph> <glyph class="state variable" id="_90277cf3-d459-48a7-b2e5-7c293fcc557d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14170.384" y="1155.0"/> </glyph> <glyph class="state variable" id="_b0853bed-4fce-4f3a-8d48-875822d2f88a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14170.75" y="1195.0"/> </glyph> <glyph class="state variable" id="_5b5f908a-b12a-4a8f-821b-aa0308219083"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="14080.75" y="1194.7223"/> </glyph> <glyph class="state variable" id="_2a914e60-8239-4e51-9fb2-28c4c3b507e3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14090.75" y="1195.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1767_wca1_wca1_sa282"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="14095.0" y="1112.0"/> <glyph class="unit of information" id="_77b2bd06-7c84-478d-9713-15062e7423c9"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14112.5" y="1107.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1768_wca1_wca1_sa281"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="14227.5" y="1137.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1769_wca1_wca1_sa280"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="14229.5" y="1097.0"/> <glyph class="state variable" id="_7b3501bb-9526-49cc-bcc1-ef440514e9cd"> <state value="" variable="S268"/> <bbox w="30.0" h="10.0" x="14214.992" y="1092.0"/> </glyph> <glyph class="state variable" id="_c4c8b2a8-81c8-4ab9-a226-dac91ced890b"> <state value="" variable="S269"/> <bbox w="30.0" h="10.0" x="14254.532" y="1092.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1770_wca1_wca1_sa279"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="53.0" h="123.0" x="14175.5" y="1016.0"/> <glyph class="state variable" id="_599308eb-78f2-4d27-b332-a34002844c58"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14223.5" y="1011.0"/> </glyph> <glyph class="state variable" id="_cf25f489-7081-46a5-a411-7b62c597b877"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="14161.345" y="1011.0"/> </glyph> <glyph class="state variable" id="_f039abee-f32d-40ae-886a-62134eb1afa9"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="14213.5" y="1011.6604"/> </glyph> <glyph class="state variable" id="_08a23a6f-600d-4d28-b856-52a25097eeab"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="14211.569" y="1134.0"/> </glyph> <glyph class="state variable" id="_ee54c1bd-aae5-494a-a434-6fa36d984b03"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="14160.659" y="1134.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1765_wca1_wca1_sa278"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein) alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 (Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 guanine nucleotide binding protein (G protein) alpha activating activity polypeptide olfactory type HUGO:GNAL HGNC:4388 ENTREZ:2774 UNIPROT:P38405 GENECARDS:GNAL REACTOME:55364 ATLASONC:GC_GNAL WIKI:GNAL guanine nucleotide binding protein (G protein) alpha activating activity polypeptide O HUGO:GNAO1 HGNC:4389 ENTREZ:2775 UNIPROT:P09471 GENECARDS:GNAO1 REACTOME:55350 KEGG:2775 ATLASONC:GC_GNAO1 WIKI:GNAO1 guanine nucleotide binding protein (G protein) q polypeptide HUGO:GNAQ HGNC:4390 ENTREZ:2776 UNIPROT:P50148 GENECARDS:GNAQ REACTOME:55454 KEGG:2776 ATLASONC:GNAQID43280ch9q21 WIKI:GNAQ Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21640127 References_end</body> </html> </notes> <label text="Gαo*"/> <bbox w="40.0" h="20.0" x="13965.5" y="1261.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1766_wca1_wca1_sa277"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="13879.75" y="1158.0"/> <glyph class="state variable" id="_3a1a90f5-0ebc-4681-b0e2-f2b9f0527d0d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="13952.25" y="1153.0"/> </glyph> <glyph class="state variable" id="_477dc627-0297-4408-ba7e-ef176fc0aba0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13874.75" y="1153.0"/> </glyph> <glyph class="state variable" id="_2d5635b2-f871-4d25-9e8d-e0f439cb6b94"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="13944.132" y="1193.0"/> </glyph> <glyph class="state variable" id="_abefa84c-800e-4388-8834-e2375db12407"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13874.75" y="1153.0"/> </glyph> <glyph class="state variable" id="_11811e3a-66f4-4f49-a12e-f1f781c92490"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13954.75" y="1153.0"/> </glyph> <glyph class="state variable" id="_8d773924-1381-48c6-9e5f-e92618bd3730"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13954.384" y="1153.0"/> </glyph> <glyph class="state variable" id="_573efae3-76df-4db9-b8ef-a69b62178d96"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13954.75" y="1193.0"/> </glyph> <glyph class="state variable" id="_1f5addda-f97b-42eb-9a0f-3ce2aff0da79"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="13864.75" y="1192.7223"/> </glyph> <glyph class="state variable" id="_3b921d1d-4dd3-481c-a17c-092c61f52b42"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13874.75" y="1193.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1767_wca1_wca1_sa275"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="13879.0" y="1110.0"/> <glyph class="unit of information" id="_572b6eb8-0116-4b25-9e95-7845e6e48a96"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="13896.5" y="1105.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1768_wca1_wca1_sa274"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="14011.5" y="1135.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1769_wca1_wca1_sa273"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="14013.5" y="1095.0"/> <glyph class="state variable" id="_f680d86c-3097-41c7-a75f-73d7f6b1ac09"> <state value="" variable="S268"/> <bbox w="30.0" h="10.0" x="13998.992" y="1090.0"/> </glyph> <glyph class="state variable" id="_5e3f2602-1195-458a-b675-32ff3cd648fb"> <state value="" variable="S269"/> <bbox w="30.0" h="10.0" x="14038.532" y="1090.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1770_wca1_wca1_sa272"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="53.0" h="123.0" x="13959.5" y="1014.0"/> <glyph class="state variable" id="_bd4f5c1f-9f78-4540-a1b4-1f53b26c3a64"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14007.5" y="1009.0"/> </glyph> <glyph class="state variable" id="_5048dd55-6a09-410e-8a51-5efbedbe4858"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="13945.345" y="1009.0"/> </glyph> <glyph class="state variable" id="_df3b54df-75e8-4dd3-91e3-5717f432d749"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="13997.5" y="1009.6604"/> </glyph> <glyph class="state variable" id="_46b7550e-6ce2-4843-91ad-3ed250e0f664"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="13995.569" y="1132.0"/> </glyph> <glyph class="state variable" id="_fe091b59-a1be-4978-b5ad-8405665540b1"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="13944.659" y="1132.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1755_wca1_wca1_sa620"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="14107.0" y="1048.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1649_wca1_wca1_sa659"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end</body> </html> </notes> <label text="PRR*"/> <bbox w="50.0" h="40.0" x="13840.182" y="1084.7273"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1650_wca1_wca1_sa689"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="13913.75" y="1153.0"/> <glyph class="state variable" id="_ddc5105e-5d37-4f5a-bdba-42ed81d2c015"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="13975.632" y="1188.0"/> </glyph> <glyph class="state variable" id="_5ec71ff0-7b6e-4034-afcb-c7562b43212d"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="13896.742" y="1148.0"/> </glyph> <glyph class="state variable" id="_fde74384-e618-489c-acf2-79a99202c226"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="13976.25" y="1148.2147"/> </glyph> <glyph class="state variable" id="_57371559-16c4-47dc-a1c4-3cd944c06a4c"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="13936.154" y="1188.0"/> </glyph> <glyph class="state variable" id="_8f444553-70c1-44eb-bf2f-a0a64eeed2b1"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="13936.282" y="1148.0"/> </glyph> <glyph class="state variable" id="_617af211-3c14-4720-9af1-ed6132ddd206"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="13896.25" y="1187.7223"/> </glyph> <glyph class="state variable" id="_377db393-fd37-4cd9-b6b1-fb58803029aa"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13988.75" y="1148.0"/> </glyph> <glyph class="state variable" id="_c075adfc-fc2e-4dad-b4fa-df4bce8c683b"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="13976.25" y="1187.1306"/> </glyph> <glyph class="state variable" id="_1621cfba-a4f8-44b4-830a-06f7e4f26a75"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="13896.25" y="1187.7223"/> </glyph> <glyph class="state variable" id="_d7d84b7a-3e28-416d-af65-f25313c8b9da"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13901.742" y="1148.0"/> </glyph> <glyph class="state variable" id="_202a6799-04fa-4736-8a47-f3377e21650d"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="13896.742" y="1148.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1771_wca1_wca1_csa37" compartmentRef="wca1_wca1_c5_wca1_wca1_ca9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:_beta_-Arrestin2*:p120* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:52226983 PMID:21606194 PMID:20460648 References_end</body> </html> </notes> <label text="(Signalosome)"/> <bbox w="505.0" h="340.0" x="14349.5" y="1002.0"/> <glyph class="macromolecule" id="wca1_wca1_s1772_wca1_wca1_sa219"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="14580.0" y="1215.0"/> <glyph class="state variable" id="_fb6ccdb2-2e3e-4d91-bd64-ba5f78ae1941"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="14567.992" y="1210.0"/> </glyph> <glyph class="state variable" id="_9f895ad5-5bfb-460e-a3a2-0e7b4c477711"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="14607.532" y="1210.0"/> </glyph> <glyph class="state variable" id="_adfe6005-f997-42fd-88ca-c3c006f47f8f"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="14645.0" y="1210.2147"/> </glyph> <glyph class="state variable" id="_22c7dd48-b5d2-4f11-b1f9-97c9a93ac0c7"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="14644.382" y="1250.0"/> </glyph> <glyph class="state variable" id="_1a0bd01f-1e44-4674-b9c9-5b170dd2046f"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="14604.904" y="1250.0"/> </glyph> <glyph class="state variable" id="_127b6dd7-073d-49b8-a70c-e32f7638bb94"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="14565.0" y="1249.7223"/> </glyph> <glyph class="state variable" id="_f0fcc78e-8ba9-49b7-853a-7577e9300437"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="14607.404" y="1250.0"/> </glyph> <glyph class="state variable" id="_e23e1be3-94d7-4f59-bb96-ffa4963852b8"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="14646.882" y="1250.0"/> </glyph> <glyph class="state variable" id="_bbd40313-3b52-4602-a1a4-ce4a88561525"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14652.5" y="1210.2147"/> </glyph> <glyph class="state variable" id="_89b156a3-6dfb-4743-a3ed-6da0af46fc2f"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="14567.5" y="1249.7223"/> </glyph> <glyph class="state variable" id="_bf9da4b9-14c5-4fdf-9036-a82972800079"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14572.992" y="1210.0"/> </glyph> <glyph class="state variable" id="_f24db77e-6a8a-475e-851f-3ae89bfcae2c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14575.0" y="1210.0"/> </glyph> <glyph class="state variable" id="_63363d18-653b-4821-8a74-0f7e7dc4824e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14655.0" y="1210.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1773_wca1_wca1_sa221"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="14664.0" y="1215.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1772_wca1_wca1_sa222"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="14745.0" y="1215.0"/> <glyph class="state variable" id="_60bcd77d-d55c-43e5-bb02-7266eedfb324"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="14732.992" y="1210.0"/> </glyph> <glyph class="state variable" id="_3ac0f46e-e7e6-4da7-b091-24aab0b412da"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="14772.532" y="1210.0"/> </glyph> <glyph class="state variable" id="_7368385a-9c8e-4f50-9468-c7075ebb31e2"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="14810.0" y="1210.2147"/> </glyph> <glyph class="state variable" id="_0da9c75c-e536-455f-96a9-b8d7f2dafec2"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="14809.382" y="1250.0"/> </glyph> <glyph class="state variable" id="_357ce2c3-a7d4-45c5-9667-578707866d65"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="14769.904" y="1250.0"/> </glyph> <glyph class="state variable" id="_a1e255b4-dc27-4894-8140-ff5fba454442"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="14730.0" y="1249.7223"/> </glyph> <glyph class="state variable" id="_456d9cf2-9058-4481-91f7-221260785ea2"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="14772.404" y="1250.0"/> </glyph> <glyph class="state variable" id="_673b8a05-ea60-478d-901c-2729f14f0326"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="14811.882" y="1250.0"/> </glyph> <glyph class="state variable" id="_ed885b23-d1a9-4833-8f36-ff74143bdc09"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14817.5" y="1210.2147"/> </glyph> <glyph class="state variable" id="_5c877c70-9f9f-4e0c-a1ab-3316ef6b06e7"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="14732.5" y="1249.7223"/> </glyph> <glyph class="state variable" id="_a893e0f4-d5cd-42d2-b2b6-99730c90a794"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14737.992" y="1210.0"/> </glyph> <glyph class="state variable" id="_6209d47b-0d9e-4b0f-8aec-155a1401f28c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14740.0" y="1210.0"/> </glyph> <glyph class="state variable" id="_889fc1a6-1215-42fe-bea5-b459c936d9cb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14820.0" y="1210.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1774_wca1_wca1_sa224"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="14576.5" y="1258.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1774_wca1_wca1_sa225"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="14743.5" y="1259.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1775_wca1_wca1_sa251"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="53.0" h="123.0" x="14486.5" y="1015.0"/> <glyph class="state variable" id="_5950cfe9-2549-448e-afda-1e0a9f0d3059"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14534.5" y="1010.0"/> </glyph> <glyph class="state variable" id="_463c3870-555e-4600-91fc-69cd89bb3a3b"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="14472.345" y="1010.0"/> </glyph> <glyph class="state variable" id="_75137621-8e84-48da-83ed-95a580c856b7"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="14524.5" y="1010.6604"/> </glyph> <glyph class="state variable" id="_d7a25af3-43bc-4863-bf0e-49b34a064f9f"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="14522.569" y="1133.0"/> </glyph> <glyph class="state variable" id="_b78a0947-6378-41b1-8d92-74730f79b8a1"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="14471.659" y="1133.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1776_wca1_wca1_sa252"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="14540.5" y="1096.0"/> <glyph class="state variable" id="_eadb4a52-ce99-4cd6-aad5-559d8f9b6cb2"> <state value="" variable="S268"/> <bbox w="30.0" h="10.0" x="14525.992" y="1091.0"/> </glyph> <glyph class="state variable" id="_d91d8c44-c71a-4daf-888d-c49df54ed605"> <state value="" variable="S269"/> <bbox w="30.0" h="10.0" x="14565.532" y="1091.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1777_wca1_wca1_sa253"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="14538.5" y="1136.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1778_wca1_wca1_sa254"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="14406.0" y="1111.0"/> <glyph class="unit of information" id="_087ceb98-fd19-44e9-bf74-7513961825e1"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14423.5" y="1106.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1779_wca1_wca1_sa256"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="14406.75" y="1159.0"/> <glyph class="state variable" id="_3ac12327-1586-4b2a-8e82-f380f765e541"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14479.25" y="1154.0"/> </glyph> <glyph class="state variable" id="_c66480dc-61e4-4a0e-92eb-dba3eebada40"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14401.75" y="1154.0"/> </glyph> <glyph class="state variable" id="_7909adaf-c8e8-4435-8edc-deed5d85f05c"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="14471.132" y="1194.0"/> </glyph> <glyph class="state variable" id="_7abe6ef6-7503-4b3a-9db7-cdbcea7a1981"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14401.75" y="1154.0"/> </glyph> <glyph class="state variable" id="_9cecdcab-04b6-4b40-aa08-2aff655e8816"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14481.75" y="1154.0"/> </glyph> <glyph class="state variable" id="_f9ce08b1-6e7c-4361-895e-70fa6648f48d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14481.384" y="1154.0"/> </glyph> <glyph class="state variable" id="_46039ba7-c7e7-4378-a18c-480a226f3494"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14481.75" y="1194.0"/> </glyph> <glyph class="state variable" id="_ad4c413c-85eb-461b-a8ec-0399955bf483"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="14391.75" y="1193.7223"/> </glyph> <glyph class="state variable" id="_50fd3780-a628-4164-9d04-8b12c379e34e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14401.75" y="1194.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1780_wca1_wca1_sa257"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein) alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 (Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 guanine nucleotide binding protein (G protein) alpha activating activity polypeptide olfactory type HUGO:GNAL HGNC:4388 ENTREZ:2774 UNIPROT:P38405 GENECARDS:GNAL REACTOME:55364 ATLASONC:GC_GNAL WIKI:GNAL guanine nucleotide binding protein (G protein) alpha activating activity polypeptide O HUGO:GNAO1 HGNC:4389 ENTREZ:2775 UNIPROT:P09471 GENECARDS:GNAO1 REACTOME:55350 KEGG:2775 ATLASONC:GC_GNAO1 WIKI:GNAO1 guanine nucleotide binding protein (G protein) q polypeptide HUGO:GNAQ HGNC:4390 ENTREZ:2776 UNIPROT:P50148 GENECARDS:GNAQ REACTOME:55454 KEGG:2776 ATLASONC:GNAQID43280ch9q21 WIKI:GNAQ Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21640127 References_end</body> </html> </notes> <label text="Gαo*"/> <bbox w="40.0" h="20.0" x="14491.5" y="1260.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1775_wca1_wca1_sa258"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="53.0" h="123.0" x="14702.5" y="1017.0"/> <glyph class="state variable" id="_7dec6796-53ef-4f75-a4ba-fbddab0d01ee"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14750.5" y="1012.0"/> </glyph> <glyph class="state variable" id="_1cede464-17ed-4ad2-ad0e-22903d4c0a40"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="14688.345" y="1012.0"/> </glyph> <glyph class="state variable" id="_e2fd7936-3c6c-4267-b382-425dc891e436"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="14740.5" y="1012.6604"/> </glyph> <glyph class="state variable" id="_6969a129-ad7c-4277-b999-ec1c30002731"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="14738.569" y="1135.0"/> </glyph> <glyph class="state variable" id="_58c27e6c-2754-4e01-9765-7bd4479efb4c"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="14687.659" y="1135.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1776_wca1_wca1_sa259"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="14756.5" y="1098.0"/> <glyph class="state variable" id="_604f705c-1393-4067-a6cc-6f1b23a3f8ad"> <state value="" variable="S268"/> <bbox w="30.0" h="10.0" x="14741.992" y="1093.0"/> </glyph> <glyph class="state variable" id="_d576b7b0-daf5-4f64-af38-7a7b4182f91e"> <state value="" variable="S269"/> <bbox w="30.0" h="10.0" x="14781.532" y="1093.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1777_wca1_wca1_sa260"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="14754.5" y="1138.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1778_wca1_wca1_sa261"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="14622.0" y="1113.0"/> <glyph class="unit of information" id="_77b28cb4-2b9b-4712-ac6e-845a32be7ae1"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14639.5" y="1108.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1779_wca1_wca1_sa263"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="14622.75" y="1161.0"/> <glyph class="state variable" id="_e4d4d28a-64d2-4977-a2c3-d6a9ea215d0e"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14695.25" y="1156.0"/> </glyph> <glyph class="state variable" id="_d6f98d6e-ac8b-4a06-8559-79447e5445dd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14617.75" y="1156.0"/> </glyph> <glyph class="state variable" id="_b6145ce9-39f9-4f35-a11c-08894d8b5a87"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="14687.132" y="1196.0"/> </glyph> <glyph class="state variable" id="_fe77c8aa-dea2-4dc4-a2b6-b69ae3d1b2ce"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14617.75" y="1156.0"/> </glyph> <glyph class="state variable" id="_ad81ede5-26f8-41f2-8f03-83bcf9bb1168"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14697.75" y="1156.0"/> </glyph> <glyph class="state variable" id="_65a29514-259e-4027-bc7f-17f725102522"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14697.384" y="1156.0"/> </glyph> <glyph class="state variable" id="_05463522-fc2c-40e2-b4d4-670a6144c087"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14697.75" y="1196.0"/> </glyph> <glyph class="state variable" id="_0dd8de57-4c33-480e-96d6-a5a6b3ff4121"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="14607.75" y="1195.7223"/> </glyph> <glyph class="state variable" id="_5bfb20cd-f5a4-4812-a5fe-110830a6f5bd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14617.75" y="1196.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1780_wca1_wca1_sa264"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein) alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 (Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 guanine nucleotide binding protein (G protein) alpha activating activity polypeptide olfactory type HUGO:GNAL HGNC:4388 ENTREZ:2774 UNIPROT:P38405 GENECARDS:GNAL REACTOME:55364 ATLASONC:GC_GNAL WIKI:GNAL guanine nucleotide binding protein (G protein) alpha activating activity polypeptide O HUGO:GNAO1 HGNC:4389 ENTREZ:2775 UNIPROT:P09471 GENECARDS:GNAO1 REACTOME:55350 KEGG:2775 ATLASONC:GC_GNAO1 WIKI:GNAO1 guanine nucleotide binding protein (G protein) q polypeptide HUGO:GNAQ HGNC:4390 ENTREZ:2776 UNIPROT:P50148 GENECARDS:GNAQ REACTOME:55454 KEGG:2776 ATLASONC:GNAQID43280ch9q21 WIKI:GNAQ Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21640127 References_end</body> </html> </notes> <label text="Gαo*"/> <bbox w="40.0" h="20.0" x="14659.5" y="1268.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1772_wca1_wca1_sa265"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="14409.0" y="1213.5"/> <glyph class="state variable" id="_b6939f44-a5a4-4b34-bd73-6936a5244dfd"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="14396.992" y="1208.5"/> </glyph> <glyph class="state variable" id="_db5142a0-9e02-4c54-b5b2-99c7969e657b"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="14436.532" y="1208.5"/> </glyph> <glyph class="state variable" id="_e73e6ccb-fd8a-4fb0-ae78-8bd9dea7ecb9"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="14474.0" y="1208.7147"/> </glyph> <glyph class="state variable" id="_bfa5c350-cdeb-4611-a0d3-ac8f3c0b5954"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="14473.382" y="1248.5"/> </glyph> <glyph class="state variable" id="_71e73d4b-cf67-40b8-9383-b17dc8eba8b2"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="14433.904" y="1248.5"/> </glyph> <glyph class="state variable" id="_a202d2f0-9b3c-4ea5-b136-11370038465e"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="14394.0" y="1248.2223"/> </glyph> <glyph class="state variable" id="_f4cb9940-5fd1-4813-ae5f-fc59f78ba0b5"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="14436.404" y="1248.5"/> </glyph> <glyph class="state variable" id="_64b85ddd-318d-4148-ad9d-2df6455df5d3"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="14475.882" y="1248.5"/> </glyph> <glyph class="state variable" id="_1ae88c76-25c6-42da-834c-a9f61936093a"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14481.5" y="1208.7147"/> </glyph> <glyph class="state variable" id="_399ce92e-6724-4359-a7b8-aa00957ce2ac"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="14396.5" y="1248.2223"/> </glyph> <glyph class="state variable" id="_e929744d-9af2-4cd8-9d3c-c2766d70bc0f"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14401.992" y="1208.5"/> </glyph> <glyph class="state variable" id="_c5535eb4-287a-485c-827a-a6cbcd1e2d83"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14404.0" y="1208.5"/> </glyph> <glyph class="state variable" id="_0bcfcddb-f522-49ea-ae60-a8805f60d515"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14484.0" y="1208.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1773_wca1_wca1_sa266"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="14494.0" y="1213.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1774_wca1_wca1_sa267"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="14408.5" y="1261.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1781_wca1_wca1_sa270"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="14406.0" y="1067.0"/> <glyph class="state variable" id="_be66c018-7cc6-470d-a6ef-fc273f3b833e"> <state value="P" variable="T1479"/> <bbox w="40.0" h="10.0" x="14386.0" y="1086.9602"/> </glyph> <glyph class="state variable" id="_8a96639c-a315-4f85-a420-574555125706"> <state value="P" variable="S1490"/> <bbox w="40.0" h="10.0" x="14426.032" y="1062.0"/> </glyph> <glyph class="state variable" id="_ccd3f10c-6029-4fc3-a255-86a6d2e63e4c"> <state value="P" variable="T1493"/> <bbox w="40.0" h="10.0" x="14466.0" y="1062.2684"/> </glyph> <glyph class="state variable" id="_be49061f-0404-4473-aed9-d3ee4afa9a7b"> <state value="P" variable="S1496"/> <bbox w="40.0" h="10.0" x="14465.382" y="1112.0"/> </glyph> <glyph class="state variable" id="_59602ab2-85f5-4491-b68e-8b0eed9259a4"> <state value="" variable="T1530"/> <bbox w="35.0" h="10.0" x="14427.6045" y="1112.0"/> </glyph> <glyph class="state variable" id="_f0d18e1d-35c9-43b1-a349-50cf7211547b"> <state value="" variable="S1533"/> <bbox w="35.0" h="10.0" x="14388.74" y="1112.0"/> </glyph> <glyph class="unit of information" id="_d1c8aaa6-f050-44e0-b3f1-64a7cd579fe4"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14423.5" y="1062.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1781_wca1_wca1_sa271"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="14622.0" y="1069.0"/> <glyph class="state variable" id="_51c83d7a-3922-4cb2-9dba-9a792c309254"> <state value="P" variable="T1479"/> <bbox w="40.0" h="10.0" x="14602.0" y="1088.9602"/> </glyph> <glyph class="state variable" id="_ebc1f328-fff2-45e3-8c6f-e585e60db68b"> <state value="P" variable="S1490"/> <bbox w="40.0" h="10.0" x="14642.032" y="1064.0"/> </glyph> <glyph class="state variable" id="_3dc24473-86f6-40b7-8dee-fc77b6703752"> <state value="P" variable="T1493"/> <bbox w="40.0" h="10.0" x="14682.0" y="1064.2684"/> </glyph> <glyph class="state variable" id="_728f8be8-0a2c-4895-965c-78874cba2683"> <state value="P" variable="S1496"/> <bbox w="40.0" h="10.0" x="14681.382" y="1114.0"/> </glyph> <glyph class="state variable" id="_ceb5b2c9-b06b-4f23-a650-0eb34c59a7c8"> <state value="" variable="T1530"/> <bbox w="35.0" h="10.0" x="14643.6045" y="1114.0"/> </glyph> <glyph class="state variable" id="_e3b195e4-67da-4703-926b-37184b747abc"> <state value="" variable="S1533"/> <bbox w="35.0" h="10.0" x="14604.74" y="1114.0"/> </glyph> <glyph class="unit of information" id="_08c123f8-6f0a-4354-8760-3940ab037614"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14639.5" y="1064.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1782_wca1_wca1_sa412"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1γ*"/> <bbox w="80.0" h="40.0" x="14754.5" y="1053.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1782_wca1_wca1_sa413"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1γ*"/> <bbox w="80.0" h="40.0" x="14541.5" y="1054.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1783_wca1_wca1_sa510"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="14490.25" y="1180.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1784_wca1_wca1_sa511"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="14531.25" y="1180.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1783_wca1_wca1_sa512"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="14704.25" y="1182.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1784_wca1_wca1_sa513"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="14745.25" y="1182.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1785_wca1_wca1_sa563"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="14666.5" y="1293.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1785_wca1_wca1_sa564"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="14488.5" y="1282.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1786_wca1_wca1_sa590"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="14540.5" y="1014.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1786_wca1_wca1_sa591"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="14757.0" y="1012.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1787_wca1_wca1_sa618"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="14643.0" y="1049.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1787_wca1_wca1_sa619"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="14423.0" y="1049.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1611_wca1_wca1_sa658"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end</body> </html> </notes> <label text="PRR*"/> <bbox w="50.0" h="40.0" x="14354.182" y="1090.7273"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1788_wca1_wca1_csa40" compartmentRef="wca1_wca1_c5_wca1_wca1_ca9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:_beta_-Arrestin2*:p120* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:52226983 PMID:21606194 PMID:20460648 s_wca1_re41(MAP:survival): PMID:21606194 ANNOTATION:CK1alpha phosphorylates E-CADHERIN on unkown residue and p-120 catenin References_end</body> </html> </notes> <label text="(Signalosome)"/> <bbox w="520.0" h="354.0" x="13826.5" y="1588.0"/> <glyph class="macromolecule" id="wca1_wca1_s1789_wca1_wca1_sa302"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="53.0" h="123.0" x="13973.5" y="1601.0"/> <glyph class="state variable" id="_4f5f35b1-f342-4582-b9c6-6db85fb11f8f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14021.5" y="1596.0"/> </glyph> <glyph class="state variable" id="_7e43d795-cfbd-4d19-987b-c703b72ddf1c"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="13959.345" y="1596.0"/> </glyph> <glyph class="state variable" id="_f31828f3-b5a0-46fc-8f6e-32bf288b753d"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="14011.5" y="1596.6604"/> </glyph> <glyph class="state variable" id="_4f291dcd-0e96-4647-a378-00bf7ca5a74d"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="14009.569" y="1719.0"/> </glyph> <glyph class="state variable" id="_02997091-b43d-4306-b8f1-4b37425443ee"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="13958.659" y="1719.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1790_wca1_wca1_sa303"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="14027.5" y="1682.0"/> <glyph class="state variable" id="_fbe0963a-1a4f-4530-bc7d-dacff7903549"> <state value="" variable="S268"/> <bbox w="30.0" h="10.0" x="14012.992" y="1677.0"/> </glyph> <glyph class="state variable" id="_5b1fb539-935a-4e30-b13b-e11eb0bafa46"> <state value="" variable="S269"/> <bbox w="30.0" h="10.0" x="14052.532" y="1677.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1791_wca1_wca1_sa304"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="14025.5" y="1722.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1792_wca1_wca1_sa305"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="13893.0" y="1697.0"/> <glyph class="unit of information" id="_04de9239-069c-491d-879d-a369892af276"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="13910.5" y="1692.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1793_wca1_wca1_sa307"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="13893.75" y="1745.0"/> <glyph class="state variable" id="_4180e76c-cd05-432c-9ead-7b3a92a049c4"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="13966.25" y="1740.0"/> </glyph> <glyph class="state variable" id="_7e1055ea-3fd0-4193-ad99-71b584c8aeb1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13888.75" y="1740.0"/> </glyph> <glyph class="state variable" id="_86cb9f2e-4cac-4993-ae3f-039d35dbc2d0"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="13958.132" y="1780.0"/> </glyph> <glyph class="state variable" id="_a34bf6c5-7ffc-45b2-a538-64cca2cf39a9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13888.75" y="1740.0"/> </glyph> <glyph class="state variable" id="_12a516fc-5382-4c28-9d78-8ef60089073a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13968.75" y="1740.0"/> </glyph> <glyph class="state variable" id="_0f1e0f45-82d6-42c6-afe4-55cb36bed927"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13968.384" y="1740.0"/> </glyph> <glyph class="state variable" id="_fad6624b-834b-473f-b281-a5591b6dd45c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13968.75" y="1780.0"/> </glyph> <glyph class="state variable" id="_872ead78-60af-4800-9448-e85e79ee9c71"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="13878.75" y="1779.7223"/> </glyph> <glyph class="state variable" id="_3de7a634-1b0c-4893-a787-44b0fa8d0817"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13888.75" y="1780.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1794_wca1_wca1_sa308"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein) alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 (Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 guanine nucleotide binding protein (G protein) alpha activating activity polypeptide olfactory type HUGO:GNAL HGNC:4388 ENTREZ:2774 UNIPROT:P38405 GENECARDS:GNAL REACTOME:55364 ATLASONC:GC_GNAL WIKI:GNAL guanine nucleotide binding protein (G protein) alpha activating activity polypeptide O HUGO:GNAO1 HGNC:4389 ENTREZ:2775 UNIPROT:P09471 GENECARDS:GNAO1 REACTOME:55350 KEGG:2775 ATLASONC:GC_GNAO1 WIKI:GNAO1 guanine nucleotide binding protein (G protein) q polypeptide HUGO:GNAQ HGNC:4390 ENTREZ:2776 UNIPROT:P50148 GENECARDS:GNAQ REACTOME:55454 KEGG:2776 ATLASONC:GNAQID43280ch9q21 WIKI:GNAQ Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21640127 References_end</body> </html> </notes> <label text="Gαo*"/> <bbox w="40.0" h="20.0" x="14144.5" y="1860.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1789_wca1_wca1_sa309"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="53.0" h="123.0" x="14189.5" y="1603.0"/> <glyph class="state variable" id="_970acce1-0d2a-4241-a964-951e71ee12d4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14237.5" y="1598.0"/> </glyph> <glyph class="state variable" id="_8f35d2ed-2126-4f06-91d1-91d92b97542d"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="14175.345" y="1598.0"/> </glyph> <glyph class="state variable" id="_6cd6b9b0-20f8-40a1-b3ad-0b803bcf3568"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="14227.5" y="1598.6604"/> </glyph> <glyph class="state variable" id="_e12cb2d4-091f-4c61-986f-201477984502"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="14225.569" y="1721.0"/> </glyph> <glyph class="state variable" id="_bcba2ec7-bd07-44df-bde5-8054424b3c64"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="14174.659" y="1721.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1790_wca1_wca1_sa310"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="14243.5" y="1684.0"/> <glyph class="state variable" id="_0354af4d-5422-46b8-8dd0-542d59f80321"> <state value="" variable="S268"/> <bbox w="30.0" h="10.0" x="14228.992" y="1679.0"/> </glyph> <glyph class="state variable" id="_06fe2a92-564a-47ec-9313-3ee912fdf7f5"> <state value="" variable="S269"/> <bbox w="30.0" h="10.0" x="14268.532" y="1679.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1791_wca1_wca1_sa311"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="14241.5" y="1724.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1792_wca1_wca1_sa312"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="14109.0" y="1699.0"/> <glyph class="unit of information" id="_43c8fcdd-5e04-432d-ab4f-443335fbc46d"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14126.5" y="1694.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1793_wca1_wca1_sa314"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="14109.75" y="1747.0"/> <glyph class="state variable" id="_469a4648-645c-4101-95da-1964e46b9ecf"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14182.25" y="1742.0"/> </glyph> <glyph class="state variable" id="_c0fbdb3b-416d-4aa5-ab54-36ad741447fb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14104.75" y="1742.0"/> </glyph> <glyph class="state variable" id="_d9657648-e3ca-46c5-9c7f-edf3d45b2ad9"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="14174.132" y="1782.0"/> </glyph> <glyph class="state variable" id="_f05163b8-f959-46be-adf1-1b9acad6745d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14104.75" y="1742.0"/> </glyph> <glyph class="state variable" id="_83df1bd2-1fce-48a0-ab93-483311b9b70f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14184.75" y="1742.0"/> </glyph> <glyph class="state variable" id="_aec24bbb-f446-4823-921f-032288bc53c0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14184.384" y="1742.0"/> </glyph> <glyph class="state variable" id="_2ed922cc-4b7e-44b4-9ce1-4e5871eb805e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14184.75" y="1782.0"/> </glyph> <glyph class="state variable" id="_73ff0398-39af-48d3-8688-29da19696e8f"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="14094.75" y="1781.7223"/> </glyph> <glyph class="state variable" id="_dd86b15e-2b97-4274-9916-be24e5b50b1d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14104.75" y="1782.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1794_wca1_wca1_sa315"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein) alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 (Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 guanine nucleotide binding protein (G protein) alpha activating activity polypeptide olfactory type HUGO:GNAL HGNC:4388 ENTREZ:2774 UNIPROT:P38405 GENECARDS:GNAL REACTOME:55364 ATLASONC:GC_GNAL WIKI:GNAL guanine nucleotide binding protein (G protein) alpha activating activity polypeptide O HUGO:GNAO1 HGNC:4389 ENTREZ:2775 UNIPROT:P09471 GENECARDS:GNAO1 REACTOME:55350 KEGG:2775 ATLASONC:GC_GNAO1 WIKI:GNAO1 guanine nucleotide binding protein (G protein) q polypeptide HUGO:GNAQ HGNC:4390 ENTREZ:2776 UNIPROT:P50148 GENECARDS:GNAQ REACTOME:55454 KEGG:2776 ATLASONC:GNAQID43280ch9q21 WIKI:GNAQ Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21640127 References_end</body> </html> </notes> <label text="Gαo*"/> <bbox w="40.0" h="20.0" x="13979.5" y="1859.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1795_wca1_wca1_sa316"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="13896.0" y="1799.5"/> <glyph class="state variable" id="_f417369a-6e0c-4829-a17a-c602952e1152"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="13883.992" y="1794.5"/> </glyph> <glyph class="state variable" id="_0e22f6ad-2a01-432e-8d0c-11c8692311d7"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="13923.532" y="1794.5"/> </glyph> <glyph class="state variable" id="_fdcfe2a3-7bd9-4bad-aac4-a5116e7801e5"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="13961.0" y="1794.7147"/> </glyph> <glyph class="state variable" id="_d1da101b-99eb-4014-bb1e-6a5730d59827"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="13960.382" y="1834.5"/> </glyph> <glyph class="state variable" id="_6611f84a-2142-4ce3-89b2-8c5d4ff27b28"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="13920.904" y="1834.5"/> </glyph> <glyph class="state variable" id="_941df2cb-bb7c-4ca3-8462-b8668835a845"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="13881.0" y="1834.2223"/> </glyph> <glyph class="state variable" id="_76a8d6b8-4d76-49b9-92a6-0fc4cd488170"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="13923.404" y="1834.5"/> </glyph> <glyph class="state variable" id="_decfe861-48b9-4ec4-9db1-08eb0370c740"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="13962.882" y="1834.5"/> </glyph> <glyph class="state variable" id="_081fd891-391a-419a-bd1f-d552f8fdcdb7"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="13968.5" y="1794.7147"/> </glyph> <glyph class="state variable" id="_4cee9505-1ba3-4c33-80ca-b05ce3f34ae8"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13883.5" y="1834.2223"/> </glyph> <glyph class="state variable" id="_2626cfa2-3713-42d9-a6ce-77f7d1b982bc"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="13888.992" y="1794.5"/> </glyph> <glyph class="state variable" id="_b379b259-d794-435c-be49-d0ae22ed4b74"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13891.0" y="1794.5"/> </glyph> <glyph class="state variable" id="_b76826bc-5cfa-429e-976f-67d8ec0d1ed4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13971.0" y="1794.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1796_wca1_wca1_sa317"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="13981.0" y="1799.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1797_wca1_wca1_sa318"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="13895.5" y="1847.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1798_wca1_wca1_sa321"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="13893.0" y="1653.0"/> <glyph class="state variable" id="_966c929b-e132-4f5b-ac3c-f5b938518897"> <state value="P" variable="T1479"/> <bbox w="40.0" h="10.0" x="13873.0" y="1672.9602"/> </glyph> <glyph class="state variable" id="_d90ce0ac-d9e4-477d-b3ea-133cec036c6c"> <state value="P" variable="S1490"/> <bbox w="40.0" h="10.0" x="13913.032" y="1648.0"/> </glyph> <glyph class="state variable" id="_8d027f89-02a4-4f8c-8319-1eb36a38568b"> <state value="P" variable="T1493"/> <bbox w="40.0" h="10.0" x="13953.0" y="1648.2684"/> </glyph> <glyph class="state variable" id="_962ffa4c-b653-41b2-a3d1-7b9143255eb9"> <state value="P" variable="S1496"/> <bbox w="40.0" h="10.0" x="13952.382" y="1698.0"/> </glyph> <glyph class="state variable" id="_d70e33da-11a0-4b6c-b23f-10b7a4adad77"> <state value="P" variable="T1530"/> <bbox w="40.0" h="10.0" x="13912.1045" y="1698.0"/> </glyph> <glyph class="state variable" id="_d8edf5c4-f7c2-4826-a0cb-da2c5f722c79"> <state value="P" variable="S1533"/> <bbox w="40.0" h="10.0" x="13873.24" y="1698.0"/> </glyph> <glyph class="unit of information" id="_b3dd4d25-b5ac-43c0-8f92-001c8dea6e39"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="13910.5" y="1648.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1798_wca1_wca1_sa322"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="14109.0" y="1655.0"/> <glyph class="state variable" id="_d31a2f2c-f5a9-4073-ae61-fe14298c97c9"> <state value="P" variable="T1479"/> <bbox w="40.0" h="10.0" x="14089.0" y="1674.9602"/> </glyph> <glyph class="state variable" id="_9b1bc1ff-7cde-41a2-83ef-ce658043e934"> <state value="P" variable="S1490"/> <bbox w="40.0" h="10.0" x="14129.032" y="1650.0"/> </glyph> <glyph class="state variable" id="_1d6fbf1f-fee5-467a-bd64-ecb8b10f4ebc"> <state value="P" variable="T1493"/> <bbox w="40.0" h="10.0" x="14169.0" y="1650.2684"/> </glyph> <glyph class="state variable" id="_53533ec3-1548-40fc-afec-5d9295cbbd53"> <state value="P" variable="S1496"/> <bbox w="40.0" h="10.0" x="14168.382" y="1700.0"/> </glyph> <glyph class="state variable" id="_d14ed7c3-f8a9-4f58-a61c-e49dd38be7d3"> <state value="P" variable="T1530"/> <bbox w="40.0" h="10.0" x="14128.1045" y="1700.0"/> </glyph> <glyph class="state variable" id="_0036ab55-49cf-4aa9-914a-4cf7d6d41896"> <state value="P" variable="S1533"/> <bbox w="40.0" h="10.0" x="14089.24" y="1700.0"/> </glyph> <glyph class="unit of information" id="_00200ba1-703d-4ed3-8417-1a30acb30cd9"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14126.5" y="1650.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1795_wca1_wca1_sa323"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="14067.0" y="1801.0"/> <glyph class="state variable" id="_41845947-07eb-43f9-a710-7f5c6559cd66"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="14054.992" y="1796.0"/> </glyph> <glyph class="state variable" id="_cc0e275a-08ff-46ca-9f39-82cba3777768"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="14094.532" y="1796.0"/> </glyph> <glyph class="state variable" id="_7525a6dc-f674-432d-a629-44ea4deeab0b"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="14132.0" y="1796.2147"/> </glyph> <glyph class="state variable" id="_142d26b7-e566-411d-b1d9-8f21fe5978a3"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="14131.382" y="1836.0"/> </glyph> <glyph class="state variable" id="_7ab5dcc9-1e6b-4af4-82ee-90db77e4a4e2"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="14091.904" y="1836.0"/> </glyph> <glyph class="state variable" id="_5f545b61-1169-41bc-a9c8-d7518c48a02f"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="14052.0" y="1835.7223"/> </glyph> <glyph class="state variable" id="_3d69505e-68a4-4d84-870c-baa6314126d3"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="14094.404" y="1836.0"/> </glyph> <glyph class="state variable" id="_1694113f-d379-4388-988c-720cd3c4e796"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="14133.882" y="1836.0"/> </glyph> <glyph class="state variable" id="_fc644910-8982-4a8e-add9-1445ca2e1861"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14139.5" y="1796.2147"/> </glyph> <glyph class="state variable" id="_58d7b7eb-e41d-4191-aa54-83c588512842"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="14054.5" y="1835.7223"/> </glyph> <glyph class="state variable" id="_0182eb64-c091-4003-8690-1020ed866c5a"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14059.992" y="1796.0"/> </glyph> <glyph class="state variable" id="_e3694c8c-8927-4c42-b19f-fa982d8ed968"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14062.0" y="1796.0"/> </glyph> <glyph class="state variable" id="_08de2ea6-d90f-4029-a2fa-af268ff9113e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14142.0" y="1796.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1797_wca1_wca1_sa324"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="14063.5" y="1844.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1796_wca1_wca1_sa326"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="14151.0" y="1801.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1797_wca1_wca1_sa328"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="14230.5" y="1845.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1795_wca1_wca1_sa329"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="14232.0" y="1801.0"/> <glyph class="state variable" id="_3a26144d-65bc-46b8-b572-3b4e2a954977"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="14219.992" y="1796.0"/> </glyph> <glyph class="state variable" id="_2df47bad-201b-44e4-99c0-01ed58bdcbdc"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="14259.532" y="1796.0"/> </glyph> <glyph class="state variable" id="_3d1e3960-0347-43f8-88d6-58717fec4376"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="14297.0" y="1796.2147"/> </glyph> <glyph class="state variable" id="_e3b49a64-39fe-4f28-833a-e54290c92732"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="14296.382" y="1836.0"/> </glyph> <glyph class="state variable" id="_824e339c-0aba-4bf2-ba78-3afb646948dc"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="14256.904" y="1836.0"/> </glyph> <glyph class="state variable" id="_33651b0c-0999-46fe-b80c-1911b3e62fa3"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="14217.0" y="1835.7223"/> </glyph> <glyph class="state variable" id="_87673339-cb80-4400-852b-1371943fc351"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="14259.404" y="1836.0"/> </glyph> <glyph class="state variable" id="_e01f300c-6156-45ff-8c9b-d81eb80d1340"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="14298.882" y="1836.0"/> </glyph> <glyph class="state variable" id="_b3982b49-78f2-4188-8280-c535c2943e25"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14304.5" y="1796.2147"/> </glyph> <glyph class="state variable" id="_80d04d5c-5d89-4901-b4b3-49a177a32628"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="14219.5" y="1835.7223"/> </glyph> <glyph class="state variable" id="_9a26b5fb-27e7-474b-bf3e-d4af44859b7a"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14224.992" y="1796.0"/> </glyph> <glyph class="state variable" id="_b9aeef2d-6b0e-41e0-b01c-4ce14a542125"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14227.0" y="1796.0"/> </glyph> <glyph class="state variable" id="_94dbab13-4874-4b21-a41c-a2074f101243"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14307.0" y="1796.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1799_wca1_wca1_sa416"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1γ*"/> <bbox w="80.0" h="40.0" x="14241.5" y="1640.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1799_wca1_wca1_sa417"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1γ*"/> <bbox w="80.0" h="40.0" x="14026.5" y="1637.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1800_wca1_wca1_sa502"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="13974.25" y="1763.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1801_wca1_wca1_sa503"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="14015.25" y="1763.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1800_wca1_wca1_sa504"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="14193.25" y="1766.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1801_wca1_wca1_sa505"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="14234.25" y="1766.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1802_wca1_wca1_sa565"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="14153.5" y="1891.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1802_wca1_wca1_sa566"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="13984.5" y="1884.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1803_wca1_wca1_sa592"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="14030.0" y="1601.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1803_wca1_wca1_sa593"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="14244.5" y="1599.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1804_wca1_wca1_sa614"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="14130.0" y="1641.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1804_wca1_wca1_sa615"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="13910.0" y="1641.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1416_wca1_wca1_sa661"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end</body> </html> </notes> <label text="PRR*"/> <bbox w="50.0" h="40.0" x="13839.182" y="1673.7273"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1805_wca1_wca1_csa41" compartmentRef="wca1_wca1_c5_wca1_wca1_ca9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:AXIN*:CK1_alpha_*:CK1_epsilon_*:CK1_gamma_*:DVL*:E-Cadherin*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:_beta_-Arrestin2*:p120* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:52226983 PMID:21606194 PMID:20460648 s_wca1_re41(MAP:survival): PMID:21606194 ANNOTATION:CK1alpha phosphorylates E-CADHERIN on unkown residue and p-120 catenin References_end</body> </html> </notes> <label text="(Signalosome)"/> <bbox w="517.0" h="357.0" x="14396.5" y="1586.0"/> <glyph class="macromolecule" id="wca1_wca1_s1806_wca1_wca1_sa330"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="53.0" h="123.0" x="14546.5" y="1599.0"/> <glyph class="state variable" id="_e849a566-ea6b-4c2c-bcd8-7c10fbbf6058"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14592.0" y="1594.0"/> </glyph> <glyph class="state variable" id="_5ce0dcb4-615a-412f-96ac-e82fe7b68fdf"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="14532.345" y="1594.0"/> </glyph> <glyph class="state variable" id="_4be17d21-cb52-42a1-a612-244e0314ad43"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="14584.5" y="1594.6604"/> </glyph> <glyph class="state variable" id="_7c3d3817-94db-4be7-82a9-c16b5a6f8916"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="14582.569" y="1717.0"/> </glyph> <glyph class="state variable" id="_458869c6-7aa9-4ec9-ab47-8a2e804a05fb"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="14531.659" y="1717.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1807_wca1_wca1_sa331"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="14600.5" y="1680.0"/> <glyph class="state variable" id="_2fd82adb-f5a1-410b-beb4-110cdf46b3ce"> <state value="P" variable="S268"/> <bbox w="35.0" h="10.0" x="14583.492" y="1675.0"/> </glyph> <glyph class="state variable" id="_a940d959-541d-48df-b207-7cbdf9e7a0b7"> <state value="P" variable="S269"/> <bbox w="35.0" h="10.0" x="14623.032" y="1675.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1808_wca1_wca1_sa332"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="14598.5" y="1720.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1809_wca1_wca1_sa333"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="14466.0" y="1695.0"/> <glyph class="unit of information" id="_1a3778fa-53bb-4ff2-9929-de7526848025"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14483.5" y="1690.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1810_wca1_wca1_sa335"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="14466.75" y="1743.0"/> <glyph class="state variable" id="_fdcf9b6d-ec2a-4804-8e56-f1aa9cc1da58"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14539.25" y="1738.0"/> </glyph> <glyph class="state variable" id="_bb068a62-3dee-4c6d-9ff1-ea4f89bac560"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14461.75" y="1738.0"/> </glyph> <glyph class="state variable" id="_8a233a7e-75da-4b0d-ae9b-72732905edfa"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="14531.132" y="1778.0"/> </glyph> <glyph class="state variable" id="_3af7b5fe-6db3-4dbf-af90-1ebcf79e89b3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14461.75" y="1738.0"/> </glyph> <glyph class="state variable" id="_21c02674-3a0e-4241-a6e3-98e01ccc1404"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14541.75" y="1738.0"/> </glyph> <glyph class="state variable" id="_781cf40b-a396-4256-aaab-36a2226d1e12"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14541.384" y="1738.0"/> </glyph> <glyph class="state variable" id="_9cfd4c15-d55b-46e4-a52e-d8260ebff0ed"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14541.75" y="1778.0"/> </glyph> <glyph class="state variable" id="_fa849aa0-a3c4-4aac-a4c7-35637a19165f"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="14451.75" y="1777.7223"/> </glyph> <glyph class="state variable" id="_7fd52d0f-ec7f-4b04-875a-678e05a7a044"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14461.75" y="1778.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1806_wca1_wca1_sa337"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="53.0" h="123.0" x="14762.5" y="1601.0"/> <glyph class="state variable" id="_bd71eea9-da44-4424-93a3-bd6ec6928d68"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14808.0" y="1596.0"/> </glyph> <glyph class="state variable" id="_540b65a4-7ba6-48ab-901f-a7b2001be738"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="14748.345" y="1596.0"/> </glyph> <glyph class="state variable" id="_ddde6097-4bf4-4bb7-81f3-c789e81f1a74"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="14800.5" y="1596.6604"/> </glyph> <glyph class="state variable" id="_353540a4-4718-45e9-9988-230cfc850560"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="14798.569" y="1719.0"/> </glyph> <glyph class="state variable" id="_dca71030-55e5-41f3-bb99-1994626e8176"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="14747.659" y="1719.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1807_wca1_wca1_sa338"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="14816.5" y="1682.0"/> <glyph class="state variable" id="_db4250bb-9fa1-4b98-b8dc-fd71acea53e6"> <state value="P" variable="S268"/> <bbox w="35.0" h="10.0" x="14799.492" y="1677.0"/> </glyph> <glyph class="state variable" id="_3e37d6c8-ef0f-421b-81f8-74e6655c8a81"> <state value="P" variable="S269"/> <bbox w="35.0" h="10.0" x="14839.032" y="1677.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1808_wca1_wca1_sa339"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end Identifiers_begin: casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1ε*"/> <bbox w="80.0" h="40.0" x="14814.5" y="1722.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1809_wca1_wca1_sa340"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="14682.0" y="1697.0"/> <glyph class="unit of information" id="_566568eb-b39c-48dd-baa8-c11d67b10d5a"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14699.5" y="1692.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1810_wca1_wca1_sa342"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="14682.75" y="1745.0"/> <glyph class="state variable" id="_464757f8-07f6-4038-a32c-d0da8c1510af"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14755.25" y="1740.0"/> </glyph> <glyph class="state variable" id="_22d6a33b-e501-4cc4-aa40-57d03541cc5a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14677.75" y="1740.0"/> </glyph> <glyph class="state variable" id="_d1549069-7c25-43f6-94b7-8bc48cfeedc1"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="14747.132" y="1780.0"/> </glyph> <glyph class="state variable" id="_771a24eb-a323-45e6-a1c3-9922de5ce78b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14677.75" y="1740.0"/> </glyph> <glyph class="state variable" id="_c103a38f-1da8-4111-aed9-543d8681c9bf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14757.75" y="1740.0"/> </glyph> <glyph class="state variable" id="_3cc7adc4-907b-48ed-9d5a-e371bcc2f160"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14757.384" y="1740.0"/> </glyph> <glyph class="state variable" id="_8545fae8-45f6-43ca-bf51-d7c0261d8957"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14757.75" y="1780.0"/> </glyph> <glyph class="state variable" id="_b04fb387-3f73-4dfb-bdee-176c892e9e9c"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="14667.75" y="1779.7223"/> </glyph> <glyph class="state variable" id="_e3f9d7c3-f6b2-4b97-a626-17d2b07149b5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14677.75" y="1780.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1811_wca1_wca1_sa343"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein) alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 (Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 guanine nucleotide binding protein (G protein) alpha activating activity polypeptide olfactory type HUGO:GNAL HGNC:4388 ENTREZ:2774 UNIPROT:P38405 GENECARDS:GNAL REACTOME:55364 ATLASONC:GC_GNAL WIKI:GNAL guanine nucleotide binding protein (G protein) alpha activating activity polypeptide O HUGO:GNAO1 HGNC:4389 ENTREZ:2775 UNIPROT:P09471 GENECARDS:GNAO1 REACTOME:55350 KEGG:2775 ATLASONC:GC_GNAO1 WIKI:GNAO1 guanine nucleotide binding protein (G protein) q polypeptide HUGO:GNAQ HGNC:4390 ENTREZ:2776 UNIPROT:P50148 GENECARDS:GNAQ REACTOME:55454 KEGG:2776 ATLASONC:GNAQID43280ch9q21 WIKI:GNAQ Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21640127 References_end</body> </html> </notes> <label text="Gαo*"/> <bbox w="40.0" h="20.0" x="14719.5" y="1849.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1812_wca1_wca1_sa344"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="14469.0" y="1797.5"/> <glyph class="state variable" id="_62cb3b26-26d6-4556-b316-4c44b6343b8d"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="14456.992" y="1792.5"/> </glyph> <glyph class="state variable" id="_061ad8d8-f9e7-4a83-8a6e-6ec508a3e325"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="14496.532" y="1792.5"/> </glyph> <glyph class="state variable" id="_9c30294b-67d4-4212-b098-c13339e7682e"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="14534.0" y="1792.7147"/> </glyph> <glyph class="state variable" id="_9b58a48f-ca83-409b-9fdb-9e648e1b66bb"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="14533.382" y="1832.5"/> </glyph> <glyph class="state variable" id="_abbb3b41-ac22-4126-8ca7-8562e86b65fe"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="14493.904" y="1832.5"/> </glyph> <glyph class="state variable" id="_176398b1-1d3d-4d0f-893a-89047edd6af5"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="14454.0" y="1832.2223"/> </glyph> <glyph class="state variable" id="_274b7cf7-6eb9-42ec-b438-da7efc2f88bd"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="14496.404" y="1832.5"/> </glyph> <glyph class="state variable" id="_56eab5bb-eee3-467f-9a7b-b09dce65286a"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="14535.882" y="1832.5"/> </glyph> <glyph class="state variable" id="_bbd0a43e-aa59-45be-9d8d-8e8f028860ad"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14541.5" y="1792.7147"/> </glyph> <glyph class="state variable" id="_c9ff1742-fb38-407c-a3d1-2c84ddf6cc7d"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="14456.5" y="1832.2223"/> </glyph> <glyph class="state variable" id="_9ea8d4f0-eba6-490c-9d38-db53f2f6dd93"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14461.992" y="1792.5"/> </glyph> <glyph class="state variable" id="_b2c055d9-d2c6-42c4-bd17-2cf77c360b72"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14464.0" y="1792.5"/> </glyph> <glyph class="state variable" id="_c33b46e0-6176-409b-aa31-f3c8cd860d48"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14544.0" y="1792.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1813_wca1_wca1_sa345"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="14554.0" y="1797.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1814_wca1_wca1_sa346"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="14468.5" y="1845.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1812_wca1_wca1_sa349"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="14640.0" y="1799.0"/> <glyph class="state variable" id="_02c0debb-2883-4190-9513-6fe34e647f17"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="14627.992" y="1794.0"/> </glyph> <glyph class="state variable" id="_bed2983b-af5f-4108-9dbc-0bc136a6b42b"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="14667.532" y="1794.0"/> </glyph> <glyph class="state variable" id="_b5640c3d-dfac-4968-968a-83120256c15f"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="14705.0" y="1794.2147"/> </glyph> <glyph class="state variable" id="_f70551d1-189f-423d-921f-d2c4cfd49fa3"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="14704.382" y="1834.0"/> </glyph> <glyph class="state variable" id="_ba0623b5-a9c9-45cc-aad5-e61af98e0145"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="14664.904" y="1834.0"/> </glyph> <glyph class="state variable" id="_55a28537-a03a-4f85-91f9-49a7c2eebe39"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="14625.0" y="1833.7223"/> </glyph> <glyph class="state variable" id="_71b1943b-e2e1-470b-9ca5-ad36e26bbabd"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="14667.404" y="1834.0"/> </glyph> <glyph class="state variable" id="_fb2efd69-530a-4c45-a8cd-adf20c64decf"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="14706.882" y="1834.0"/> </glyph> <glyph class="state variable" id="_fb96a295-0279-4b43-830f-e2e5236f8cd7"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14712.5" y="1794.2147"/> </glyph> <glyph class="state variable" id="_bf3c24a8-07b0-4d17-955f-9482b6bc7928"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="14627.5" y="1833.7223"/> </glyph> <glyph class="state variable" id="_bb59fd8f-f0ab-46eb-a99a-3c764216af11"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14632.992" y="1794.0"/> </glyph> <glyph class="state variable" id="_07690912-dc4a-41a2-b7ff-bc55e559f53f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14635.0" y="1794.0"/> </glyph> <glyph class="state variable" id="_382afb0e-76f1-4974-86bf-e3f94eddc509"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14715.0" y="1794.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1814_wca1_wca1_sa350"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="14636.5" y="1842.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1813_wca1_wca1_sa352"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="14724.0" y="1799.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1814_wca1_wca1_sa354"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="14803.5" y="1843.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1812_wca1_wca1_sa355"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="14805.0" y="1799.0"/> <glyph class="state variable" id="_70888937-2a80-4c5d-959f-9a0f8aa12d10"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="14792.992" y="1794.0"/> </glyph> <glyph class="state variable" id="_de5d14c8-3cd1-4e68-b54f-e36cc9e1a3ef"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="14832.532" y="1794.0"/> </glyph> <glyph class="state variable" id="_2844f051-571c-4e08-8108-943e34090b38"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="14870.0" y="1794.2147"/> </glyph> <glyph class="state variable" id="_370d5d6b-f884-4c3a-9aa6-2c259f9cc6d9"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="14869.382" y="1834.0"/> </glyph> <glyph class="state variable" id="_a710c642-8743-4d35-96a0-d820c8d6c50f"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="14829.904" y="1834.0"/> </glyph> <glyph class="state variable" id="_d5a0f447-a1c0-47c4-8cc6-ff8d2d973421"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="14790.0" y="1833.7223"/> </glyph> <glyph class="state variable" id="_3f062773-8652-4f78-9874-4061e5d76e49"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="14832.404" y="1834.0"/> </glyph> <glyph class="state variable" id="_bd731123-cbe8-42c3-91a1-de51f5500c6a"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="14871.882" y="1834.0"/> </glyph> <glyph class="state variable" id="_204ea75a-153a-4736-8e69-39c956fcae8b"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14877.5" y="1794.2147"/> </glyph> <glyph class="state variable" id="_1829ee85-73cd-484e-9974-582eda7dbf26"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="14792.5" y="1833.7223"/> </glyph> <glyph class="state variable" id="_857d6819-e72e-4dda-93c0-b278b1dfc6e0"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14797.992" y="1794.0"/> </glyph> <glyph class="state variable" id="_c26ed3b3-4404-4162-b116-d40e3064c015"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14800.0" y="1794.0"/> </glyph> <glyph class="state variable" id="_edaba93c-15ac-4c7c-b086-f572db5bfe5b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14880.0" y="1794.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1815_wca1_wca1_sa356"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="14466.0" y="1651.0"/> <glyph class="state variable" id="_f7d93cae-b00f-474b-a75d-cecae9d9625a"> <state value="P" variable="T1479"/> <bbox w="40.0" h="10.0" x="14446.0" y="1670.9602"/> </glyph> <glyph class="state variable" id="_ccafb11a-243e-4bd6-8f88-4dc1dc16b98e"> <state value="P" variable="S1490"/> <bbox w="40.0" h="10.0" x="14486.032" y="1646.0"/> </glyph> <glyph class="state variable" id="_336cfc5c-3dd4-4841-90cc-310e61a4f3b2"> <state value="P" variable="T1493"/> <bbox w="40.0" h="10.0" x="14526.0" y="1646.2684"/> </glyph> <glyph class="state variable" id="_1575f4de-a122-4377-b7c4-c14ecd27ebb2"> <state value="P" variable="S1496"/> <bbox w="40.0" h="10.0" x="14525.382" y="1696.0"/> </glyph> <glyph class="state variable" id="_9fd3d354-e938-4e7d-91d5-08f22069a7c7"> <state value="P" variable="T1530"/> <bbox w="40.0" h="10.0" x="14485.1045" y="1696.0"/> </glyph> <glyph class="state variable" id="_1ff3cc30-4607-4cb8-b4e7-45d3996d0a0c"> <state value="P" variable="S1533"/> <bbox w="40.0" h="10.0" x="14446.24" y="1696.0"/> </glyph> <glyph class="unit of information" id="_d4a1b10c-85db-4761-b323-19608611a81f"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14483.5" y="1646.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1815_wca1_wca1_sa357"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="14682.0" y="1653.0"/> <glyph class="state variable" id="_d18e76bc-c8bc-4f5f-9fe7-450aeff81288"> <state value="P" variable="T1479"/> <bbox w="40.0" h="10.0" x="14662.0" y="1672.9602"/> </glyph> <glyph class="state variable" id="_f092bac0-506d-4165-84f1-748cbab9252b"> <state value="P" variable="S1490"/> <bbox w="40.0" h="10.0" x="14702.032" y="1648.0"/> </glyph> <glyph class="state variable" id="_6dcb3c1e-84c0-4ab3-aafb-cf8f850c064e"> <state value="P" variable="T1493"/> <bbox w="40.0" h="10.0" x="14742.0" y="1648.2684"/> </glyph> <glyph class="state variable" id="_fa070eb6-c3c9-4179-9a52-a502ca511586"> <state value="P" variable="S1496"/> <bbox w="40.0" h="10.0" x="14741.382" y="1698.0"/> </glyph> <glyph class="state variable" id="_0b148916-8389-46c4-8854-f94e8f7438ea"> <state value="P" variable="T1530"/> <bbox w="40.0" h="10.0" x="14701.1045" y="1698.0"/> </glyph> <glyph class="state variable" id="_d941e13a-1587-40a3-bf22-49f10124121c"> <state value="P" variable="S1533"/> <bbox w="40.0" h="10.0" x="14662.24" y="1698.0"/> </glyph> <glyph class="unit of information" id="_5b930d3a-32bf-4dfd-b695-124a237310f9"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14699.5" y="1648.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1811_wca1_wca1_sa389"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein) alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 (Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 guanine nucleotide binding protein (G protein) alpha activating activity polypeptide olfactory type HUGO:GNAL HGNC:4388 ENTREZ:2774 UNIPROT:P38405 GENECARDS:GNAL REACTOME:55364 ATLASONC:GC_GNAL WIKI:GNAL guanine nucleotide binding protein (G protein) alpha activating activity polypeptide O HUGO:GNAO1 HGNC:4389 ENTREZ:2775 UNIPROT:P09471 GENECARDS:GNAO1 REACTOME:55350 KEGG:2775 ATLASONC:GC_GNAO1 WIKI:GNAO1 guanine nucleotide binding protein (G protein) q polypeptide HUGO:GNAQ HGNC:4390 ENTREZ:2776 UNIPROT:P50148 GENECARDS:GNAQ REACTOME:55454 KEGG:2776 ATLASONC:GNAQID43280ch9q21 WIKI:GNAQ Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21640127 References_end</body> </html> </notes> <label text="Gαo*"/> <bbox w="40.0" h="20.0" x="14551.75" y="1851.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1816_wca1_wca1_sa420"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1γ*"/> <bbox w="80.0" h="40.0" x="14815.5" y="1638.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1816_wca1_wca1_sa421"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1γ*"/> <bbox w="80.0" h="40.0" x="14600.5" y="1636.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1817_wca1_wca1_sa496"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="14549.25" y="1763.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1818_wca1_wca1_sa497"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="14590.25" y="1763.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1817_wca1_wca1_sa498"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="14764.25" y="1764.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1818_wca1_wca1_sa499"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="14805.25" y="1764.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1819_wca1_wca1_sa567"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="14722.5" y="1873.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1819_wca1_wca1_sa568"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="14552.5" y="1876.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1820_wca1_wca1_sa594"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="14595.5" y="1594.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1820_wca1_wca1_sa595"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="14814.0" y="1599.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1821_wca1_wca1_sa616"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="14704.0" y="1629.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1821_wca1_wca1_sa617"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="14484.0" y="1629.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1415_wca1_wca1_sa660"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end</body> </html> </notes> <label text="PRR*"/> <bbox w="50.0" h="40.0" x="14412.182" y="1677.7273"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1822_wca1_wca1_csa42" compartmentRef="wca1_wca1_c5_wca1_wca1_ca9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:AXIN*:CK1_alpha_*:CK1_gamma_*:DVL*:FZD*:GSK3*:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:_beta_-Arrestin2* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:52226983 PMID:21606194 PMID:20460648 s_wca1_re43(MAP:survival): PMID:21606194 PMID:21285348 DVL is again phosphorylated to form PS-DVL. This isoform of DVL leads to depolimerisation of DVL and even distribution in the cell. Which CK1 isoform catalyses this reaction is unknown References_end</body> </html> </notes> <label text="(Signalosome)"/> <bbox w="510.0" h="301.0" x="14038.5" y="1955.0"/> <glyph class="macromolecule" id="wca1_wca1_s1823_wca1_wca1_sa359"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="14110.0" y="2042.0"/> <glyph class="unit of information" id="_c267c5cf-dfba-490e-b7bd-e116ad80cfec"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14127.5" y="2037.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1824_wca1_wca1_sa361"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="14110.75" y="2090.0"/> <glyph class="state variable" id="_5722cdd5-7eaf-4fe4-96ef-405a51c5b4c3"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14183.25" y="2085.0"/> </glyph> <glyph class="state variable" id="_47ef126d-00c8-4e05-a71a-5105525cb150"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14105.75" y="2085.0"/> </glyph> <glyph class="state variable" id="_8e50e6ad-e5a7-4057-adb6-8bf332fa7b93"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="14175.132" y="2125.0"/> </glyph> <glyph class="state variable" id="_6b91d40d-f3e4-404d-b7e1-ba0245ea8fd3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14105.75" y="2085.0"/> </glyph> <glyph class="state variable" id="_59db5658-0305-4fe1-822f-cfcdf8532567"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14185.75" y="2085.0"/> </glyph> <glyph class="state variable" id="_7701d38e-e338-4248-9a3d-d56057480f4c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14185.384" y="2085.0"/> </glyph> <glyph class="state variable" id="_5056eab7-4dda-4b9d-b88c-784ca4301dc6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14185.75" y="2125.0"/> </glyph> <glyph class="state variable" id="_f4c72cb4-efc1-4bdc-b348-f0843db8e554"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="14095.75" y="2124.7224"/> </glyph> <glyph class="state variable" id="_6f88e21d-4263-479b-a781-9c2f5f5b764a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14105.75" y="2125.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1825_wca1_wca1_sa362"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein) alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 (Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 guanine nucleotide binding protein (G protein) alpha activating activity polypeptide olfactory type HUGO:GNAL HGNC:4388 ENTREZ:2774 UNIPROT:P38405 GENECARDS:GNAL REACTOME:55364 ATLASONC:GC_GNAL WIKI:GNAL guanine nucleotide binding protein (G protein) alpha activating activity polypeptide O HUGO:GNAO1 HGNC:4389 ENTREZ:2775 UNIPROT:P09471 GENECARDS:GNAO1 REACTOME:55350 KEGG:2775 ATLASONC:GC_GNAO1 WIKI:GNAO1 guanine nucleotide binding protein (G protein) q polypeptide HUGO:GNAQ HGNC:4390 ENTREZ:2776 UNIPROT:P50148 GENECARDS:GNAQ REACTOME:55454 KEGG:2776 ATLASONC:GNAQID43280ch9q21 WIKI:GNAQ Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21640127 References_end</body> </html> </notes> <label text="Gαo*"/> <bbox w="40.0" h="20.0" x="14365.5" y="2198.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1823_wca1_wca1_sa364"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="14326.0" y="2044.0"/> <glyph class="unit of information" id="_ecd3b408-972a-44ea-95bb-13880578e7a5"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14343.5" y="2039.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1824_wca1_wca1_sa366"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="14326.75" y="2092.0"/> <glyph class="state variable" id="_bb321cc3-8176-4467-b74a-6ad006fefeca"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14399.25" y="2087.0"/> </glyph> <glyph class="state variable" id="_c9fad32e-fca1-4bc6-9af1-e403cf28a933"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14321.75" y="2087.0"/> </glyph> <glyph class="state variable" id="_7c55b0e5-0947-48d1-9d48-ff7796dc5eec"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="14391.132" y="2127.0"/> </glyph> <glyph class="state variable" id="_711f4e8f-e056-4f4b-b5a0-34c19380b02e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14321.75" y="2087.0"/> </glyph> <glyph class="state variable" id="_ad109546-9fa1-4551-8eb5-02836faae822"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14401.75" y="2087.0"/> </glyph> <glyph class="state variable" id="_f9f44c55-58f3-4591-876c-cb812f244266"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14401.384" y="2087.0"/> </glyph> <glyph class="state variable" id="_3d9d25bd-bbdb-4829-8177-e523e5721add"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14401.75" y="2127.0"/> </glyph> <glyph class="state variable" id="_db4e4bb2-5abe-4a77-9f54-b4c0f7dc5fbb"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="14311.75" y="2126.7224"/> </glyph> <glyph class="state variable" id="_530c8064-9ca8-42df-9cbd-c9b03208c8cb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14321.75" y="2127.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1825_wca1_wca1_sa367"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein) alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 (Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 guanine nucleotide binding protein (G protein) alpha activating activity polypeptide olfactory type HUGO:GNAL HGNC:4388 ENTREZ:2774 UNIPROT:P38405 GENECARDS:GNAL REACTOME:55364 ATLASONC:GC_GNAL WIKI:GNAL guanine nucleotide binding protein (G protein) alpha activating activity polypeptide O HUGO:GNAO1 HGNC:4389 ENTREZ:2775 UNIPROT:P09471 GENECARDS:GNAO1 REACTOME:55350 KEGG:2775 ATLASONC:GC_GNAO1 WIKI:GNAO1 guanine nucleotide binding protein (G protein) q polypeptide HUGO:GNAQ HGNC:4390 ENTREZ:2776 UNIPROT:P50148 GENECARDS:GNAQ REACTOME:55454 KEGG:2776 ATLASONC:GNAQID43280ch9q21 WIKI:GNAQ Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21640127 References_end</body> </html> </notes> <label text="Gαo*"/> <bbox w="40.0" h="20.0" x="14194.5" y="2196.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1826_wca1_wca1_sa368"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="14113.0" y="2144.5"/> <glyph class="state variable" id="_f0884d94-65c4-4368-bca7-c50061b79b07"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="14100.992" y="2139.5"/> </glyph> <glyph class="state variable" id="_04e9e8bf-6f91-44b0-851b-0946ed77ede8"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="14140.532" y="2139.5"/> </glyph> <glyph class="state variable" id="_91f393a5-2908-4a6f-8e0c-571aa80f1a21"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="14178.0" y="2139.7148"/> </glyph> <glyph class="state variable" id="_98a0f360-004c-422f-829a-d0797d24ac3f"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="14177.382" y="2179.5"/> </glyph> <glyph class="state variable" id="_e4c1f53f-6ee8-46cd-a667-6f61b4f6199d"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="14137.904" y="2179.5"/> </glyph> <glyph class="state variable" id="_6b11a7d9-0dd2-41b5-b4cd-afbb9cd5bb79"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="14098.0" y="2179.2224"/> </glyph> <glyph class="state variable" id="_6f47c970-607a-48f2-a5ee-b685e2ffa7d0"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="14140.404" y="2179.5"/> </glyph> <glyph class="state variable" id="_9a18493f-bc65-41fc-bcaa-c292c7f54a94"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="14179.882" y="2179.5"/> </glyph> <glyph class="state variable" id="_a6bb89e5-9b26-4fb6-948a-82502de908f6"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14185.5" y="2139.7148"/> </glyph> <glyph class="state variable" id="_8d4b62f3-8c49-4b3a-aa54-f3c822dfebed"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="14100.5" y="2179.2224"/> </glyph> <glyph class="state variable" id="_5d23c6cf-3bc8-485f-972b-6767742a9c28"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14105.992" y="2139.5"/> </glyph> <glyph class="state variable" id="_24dcd76e-49e6-4327-8af8-e7469f841a7e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14108.0" y="2139.5"/> </glyph> <glyph class="state variable" id="_49f10a71-f8cc-4a50-b751-48deb3626c71"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14188.0" y="2139.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1827_wca1_wca1_sa369"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="14198.0" y="2144.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1828_wca1_wca1_sa370"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="14112.5" y="2192.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1829_wca1_wca1_sa371"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="14192.5" y="2100.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1830_wca1_wca1_sa372"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="14233.5" y="2100.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1826_wca1_wca1_sa373"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="14284.0" y="2146.0"/> <glyph class="state variable" id="_b79484cd-100f-4556-a259-2823863151ee"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="14271.992" y="2141.0"/> </glyph> <glyph class="state variable" id="_d869bd06-5a43-4019-a59d-5b6177912bb2"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="14311.532" y="2141.0"/> </glyph> <glyph class="state variable" id="_50365e68-cb37-44f4-b739-009ed109ab13"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="14349.0" y="2141.2148"/> </glyph> <glyph class="state variable" id="_3799550d-cbb9-46af-a2a2-783b1435b7af"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="14348.382" y="2181.0"/> </glyph> <glyph class="state variable" id="_8f556f18-0a38-4cfc-a329-da6efd898b31"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="14308.904" y="2181.0"/> </glyph> <glyph class="state variable" id="_a5657b09-84b9-4ac6-a8cb-8d6c7e262df5"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="14269.0" y="2180.7224"/> </glyph> <glyph class="state variable" id="_45cf0bc7-652d-48d0-a984-4d608d550982"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="14311.404" y="2181.0"/> </glyph> <glyph class="state variable" id="_41886af9-631d-49b4-965d-459b626b95d6"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="14350.882" y="2181.0"/> </glyph> <glyph class="state variable" id="_853d9faa-feb3-4870-9064-3cee6a874fc3"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14356.5" y="2141.2148"/> </glyph> <glyph class="state variable" id="_58434b34-3594-4805-ab12-2d678ca78247"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="14271.5" y="2180.7224"/> </glyph> <glyph class="state variable" id="_01a69d08-ace1-4e80-8999-58bff63cfc58"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14276.992" y="2141.0"/> </glyph> <glyph class="state variable" id="_a711640d-0b87-4469-babc-f85cf9ca548a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14279.0" y="2141.0"/> </glyph> <glyph class="state variable" id="_49c0134d-6a8e-4fc8-9996-37c307e15ea2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14359.0" y="2141.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1828_wca1_wca1_sa374"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="14280.5" y="2189.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1827_wca1_wca1_sa376"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="14368.0" y="2146.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1828_wca1_wca1_sa378"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="14447.5" y="2190.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1826_wca1_wca1_sa379"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="14449.0" y="2146.0"/> <glyph class="state variable" id="_78d34e2d-f8f6-41b8-9005-f7e7f7f799be"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="14436.992" y="2141.0"/> </glyph> <glyph class="state variable" id="_0c32fb8e-5033-4338-b9f6-7b0e98f1b8d0"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="14476.532" y="2141.0"/> </glyph> <glyph class="state variable" id="_dd97e741-36b8-4eab-b71b-25692a094980"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="14514.0" y="2141.2148"/> </glyph> <glyph class="state variable" id="_be14ba48-588b-4d03-964b-fe4ea4b52fd2"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="14513.382" y="2181.0"/> </glyph> <glyph class="state variable" id="_78dc9eea-7c6f-4b8e-99c5-89261c08ecb7"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="14473.904" y="2181.0"/> </glyph> <glyph class="state variable" id="_ec55188b-2ab3-4dc3-a965-ec0f95bac785"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="14434.0" y="2180.7224"/> </glyph> <glyph class="state variable" id="_97f79751-2759-478c-a216-a69f890a7c4a"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="14476.404" y="2181.0"/> </glyph> <glyph class="state variable" id="_96617559-d937-4361-b425-479e3edb7caf"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="14515.882" y="2181.0"/> </glyph> <glyph class="state variable" id="_0c931a55-2a50-4752-a7b9-ac15c62e5b1c"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14521.5" y="2141.2148"/> </glyph> <glyph class="state variable" id="_e31f74ec-1eb7-449c-a51d-8ef300091e3f"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="14436.5" y="2180.7224"/> </glyph> <glyph class="state variable" id="_9b42a21d-b1bb-4f1b-94a0-0c13a5494fa0"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14441.992" y="2141.0"/> </glyph> <glyph class="state variable" id="_7bca2559-7ff2-4f67-896c-16dff1e220a6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14444.0" y="2141.0"/> </glyph> <glyph class="state variable" id="_1a7d49b5-6243-4ea5-a84d-93d6a512e6fc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14524.0" y="2141.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1831_wca1_wca1_sa380"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="14110.0" y="1998.0"/> <glyph class="state variable" id="_4774bf55-7c08-499b-98ba-5fcc3309e44d"> <state value="P" variable="T1479"/> <bbox w="40.0" h="10.0" x="14090.0" y="2017.9602"/> </glyph> <glyph class="state variable" id="_11d12b7a-f8e8-43d6-876e-2e9294135b8d"> <state value="P" variable="S1490"/> <bbox w="40.0" h="10.0" x="14130.032" y="1993.0"/> </glyph> <glyph class="state variable" id="_7e70ba9b-3d31-417a-ba79-e248a4ed8249"> <state value="P" variable="T1493"/> <bbox w="40.0" h="10.0" x="14170.0" y="1993.2684"/> </glyph> <glyph class="state variable" id="_ab7b215e-23c4-4673-9bf0-460c2783f9d9"> <state value="P" variable="S1496"/> <bbox w="40.0" h="10.0" x="14169.382" y="2043.0"/> </glyph> <glyph class="state variable" id="_ecf39a28-f0ba-4216-9662-a0e4b7380193"> <state value="P" variable="T1530"/> <bbox w="40.0" h="10.0" x="14129.1045" y="2043.0"/> </glyph> <glyph class="state variable" id="_026e3702-a30b-4b36-804e-fe91f2205cb5"> <state value="P" variable="S1533"/> <bbox w="40.0" h="10.0" x="14090.24" y="2043.0"/> </glyph> <glyph class="unit of information" id="_93ca285b-616f-4583-a385-882377c4c7ca"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14127.5" y="1993.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1831_wca1_wca1_sa381"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="14326.0" y="2000.0"/> <glyph class="state variable" id="_eba86d52-2530-4cc3-8000-f833e33f2d6f"> <state value="P" variable="T1479"/> <bbox w="40.0" h="10.0" x="14306.0" y="2019.9602"/> </glyph> <glyph class="state variable" id="_8b5d4851-67ac-4ddb-9325-768ff4851b62"> <state value="P" variable="S1490"/> <bbox w="40.0" h="10.0" x="14346.032" y="1995.0"/> </glyph> <glyph class="state variable" id="_44c5fb75-20f0-4430-a2b9-41ab3a0b9770"> <state value="P" variable="T1493"/> <bbox w="40.0" h="10.0" x="14386.0" y="1995.2684"/> </glyph> <glyph class="state variable" id="_eeaa2dd8-9abf-44dc-969b-8b4d0254c4b1"> <state value="P" variable="S1496"/> <bbox w="40.0" h="10.0" x="14385.382" y="2045.0"/> </glyph> <glyph class="state variable" id="_989c5f23-6fb2-45c3-94af-8bf36e0ad345"> <state value="P" variable="T1530"/> <bbox w="40.0" h="10.0" x="14345.1045" y="2045.0"/> </glyph> <glyph class="state variable" id="_4de0b125-ec06-43c1-ab66-b355545d3f77"> <state value="P" variable="S1533"/> <bbox w="40.0" h="10.0" x="14306.24" y="2045.0"/> </glyph> <glyph class="unit of information" id="_1d16e9bf-8adf-4d04-89ac-cc63e14b21ec"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14343.5" y="1995.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1832_wca1_wca1_sa424"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1γ*"/> <bbox w="80.0" h="40.0" x="14406.5" y="2045.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1832_wca1_wca1_sa425"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1γ*"/> <bbox w="80.0" h="40.0" x="14192.5" y="2041.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1829_wca1_wca1_sa494"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="14408.25" y="2102.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1830_wca1_wca1_sa495"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="14449.25" y="2102.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1833_wca1_wca1_sa569"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="14412.5" y="2001.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1833_wca1_wca1_sa570"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="14194.5" y="2001.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1834_wca1_wca1_sa596"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="14193.0" y="1960.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1834_wca1_wca1_sa597"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="14411.5" y="1965.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1835_wca1_wca1_sa612"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="14352.0" y="1985.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1835_wca1_wca1_sa613"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="14132.0" y="1985.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1417_wca1_wca1_sa662"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end</body> </html> </notes> <label text="PRR*"/> <bbox w="50.0" h="40.0" x="14052.182" y="2015.8182"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1836_wca1_wca1_csa44" compartmentRef="wca1_wca1_c5_wca1_wca1_ca9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:CK1_gamma_*:DVL*:FZD*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:_beta_-Arrestin2* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:52226983 PMID:21606194 PMID:20460648 s_wca1_re43(MAP:survival): PMID:21606194 PMID:21285348 DVL is again phosphorylated to form PS-DVL. This isoform of DVL leads to depolimerisation of DVL and even distribution in the cell. Which CK1 isoform catalyses this reaction is unknown References_end</body> </html> </notes> <label text="(Signalosome)"/> <bbox w="339.25" h="201.5" x="13798.75" y="2353.0"/> <glyph class="macromolecule" id="wca1_wca1_s1837_wca1_wca1_sa386"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="13809.25" y="2433.5"/> <glyph class="unit of information" id="_3c52e0fa-7791-430a-a0da-e9e441d1b64a"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="13826.75" y="2428.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1838_wca1_wca1_sa388"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="13810.0" y="2481.5"/> <glyph class="state variable" id="_ac1c3c9a-b74b-4272-93ea-411422cbc61f"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="13882.5" y="2476.5"/> </glyph> <glyph class="state variable" id="_c520c373-ea1b-450c-ac65-83c532a4e638"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="13802.5" y="2476.5"/> </glyph> <glyph class="state variable" id="_bcb3d8e7-6e97-4a0a-b786-c2b53781bce3"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="13874.382" y="2516.5"/> </glyph> <glyph class="state variable" id="_4ef8afbc-1398-4f4d-810d-19cf73ba5cf7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13805.0" y="2476.5"/> </glyph> <glyph class="state variable" id="_c4216ba4-9356-4a28-9cbf-019d369fbb68"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13885.0" y="2476.5"/> </glyph> <glyph class="state variable" id="_f6644c29-369b-4747-a5af-1735df316bcf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13884.634" y="2476.5"/> </glyph> <glyph class="state variable" id="_47138fc3-c6c0-4260-93b9-d237d4b6944d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13885.0" y="2516.5"/> </glyph> <glyph class="state variable" id="_cb7b4468-33ee-438a-a98d-e206b0601845"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="13795.0" y="2516.2224"/> </glyph> <glyph class="state variable" id="_eac434c6-ff68-407f-9a40-31504bd12c45"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13805.0" y="2516.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1837_wca1_wca1_sa390"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="13970.25" y="2434.5"/> <glyph class="unit of information" id="_69071ad6-b180-4d93-aa34-814fe270fb3a"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="13987.75" y="2429.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1838_wca1_wca1_sa392"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="13971.0" y="2482.5"/> <glyph class="state variable" id="_fff5879f-166f-4ff9-b1df-759308f16f1e"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14043.5" y="2477.5"/> </glyph> <glyph class="state variable" id="_a89f95f3-6829-4348-a0d0-50a76d8a131a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="13963.5" y="2477.5"/> </glyph> <glyph class="state variable" id="_8eee659e-f2d7-439e-91c3-be43f301bc53"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="14035.382" y="2517.5"/> </glyph> <glyph class="state variable" id="_ddd590b5-9470-4e03-989c-245d6e5eacce"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13966.0" y="2477.5"/> </glyph> <glyph class="state variable" id="_46c6d742-22f3-454d-b5bc-bdb098ad6525"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14046.0" y="2477.5"/> </glyph> <glyph class="state variable" id="_f01ada33-3f8b-4087-bea4-1e75e9ccf122"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14045.634" y="2477.5"/> </glyph> <glyph class="state variable" id="_c2d9ffb7-62f6-4097-b7f7-a50edb86dc26"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14046.0" y="2517.5"/> </glyph> <glyph class="state variable" id="_2d89225b-3718-4eb1-80cf-80ece4a3a8ed"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="13956.0" y="2517.2224"/> </glyph> <glyph class="state variable" id="_312b5890-8f44-42a3-9607-a144e83fdb92"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13966.0" y="2517.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1444_wca1_wca1_sa397"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="13890.75" y="2494.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1445_wca1_wca1_sa398"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="13933.75" y="2494.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1839_wca1_wca1_sa406"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="13809.25" y="2389.5"/> <glyph class="state variable" id="_538c566f-c9c9-4eb8-b3f6-35f8f8570028"> <state value="P" variable="T1479"/> <bbox w="40.0" h="10.0" x="13789.25" y="2409.4602"/> </glyph> <glyph class="state variable" id="_9d79573e-88e3-4006-a231-b7e4cabbb044"> <state value="P" variable="S1490"/> <bbox w="40.0" h="10.0" x="13829.282" y="2384.5"/> </glyph> <glyph class="state variable" id="_d06b7657-e019-4914-b9e2-3c9ab1eaf355"> <state value="P" variable="T1493"/> <bbox w="40.0" h="10.0" x="13869.25" y="2384.7686"/> </glyph> <glyph class="state variable" id="_123ecca7-6ca2-4aca-aded-97f2487030cd"> <state value="P" variable="S1496"/> <bbox w="40.0" h="10.0" x="13868.632" y="2434.5"/> </glyph> <glyph class="state variable" id="_dfc83949-8b52-4bc8-8e39-058320190ee7"> <state value="P" variable="T1530"/> <bbox w="40.0" h="10.0" x="13828.3545" y="2434.5"/> </glyph> <glyph class="state variable" id="_6d4de159-277c-4484-8afe-101aed9ce435"> <state value="P" variable="S1533"/> <bbox w="40.0" h="10.0" x="13789.49" y="2434.5"/> </glyph> <glyph class="unit of information" id="_9f2addc3-43ae-4382-93c6-49300ee0690c"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="13826.75" y="2384.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1839_wca1_wca1_sa407"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="13970.25" y="2390.5"/> <glyph class="state variable" id="_2301913b-71f1-4101-b35d-43a52b8a3184"> <state value="P" variable="T1479"/> <bbox w="40.0" h="10.0" x="13950.25" y="2410.4602"/> </glyph> <glyph class="state variable" id="_0499a787-131d-4a99-ba77-2a0fae493564"> <state value="P" variable="S1490"/> <bbox w="40.0" h="10.0" x="13990.282" y="2385.5"/> </glyph> <glyph class="state variable" id="_c11b7ad9-6607-44f6-903e-829188f7c7a8"> <state value="P" variable="T1493"/> <bbox w="40.0" h="10.0" x="14030.25" y="2385.7686"/> </glyph> <glyph class="state variable" id="_9898e4be-b8b0-4ab0-80ac-9b4132a43690"> <state value="P" variable="S1496"/> <bbox w="40.0" h="10.0" x="14029.632" y="2435.5"/> </glyph> <glyph class="state variable" id="_a805f190-337f-4fa3-a011-cd35ea999113"> <state value="P" variable="T1530"/> <bbox w="40.0" h="10.0" x="13989.3545" y="2435.5"/> </glyph> <glyph class="state variable" id="_a0587254-1312-46f1-a03b-a4663f78bab0"> <state value="P" variable="S1533"/> <bbox w="40.0" h="10.0" x="13950.49" y="2435.5"/> </glyph> <glyph class="unit of information" id="_c506b62e-a5e7-454d-8d40-06f90966fb76"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="13987.75" y="2385.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1840_wca1_wca1_sa422"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1γ*"/> <bbox w="80.0" h="40.0" x="14051.5" y="2435.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1840_wca1_wca1_sa423"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1γ*"/> <bbox w="80.0" h="40.0" x="13890.5" y="2433.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1446_wca1_wca1_sa572"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="14055.5" y="2482.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1841_wca1_wca1_sa598"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="13889.5" y="2393.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1841_wca1_wca1_sa599"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="14051.5" y="2393.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1842_wca1_wca1_sa610"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="13828.0" y="2373.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1842_wca1_wca1_sa611"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="13998.0" y="2373.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1447_wca1_wca1_sa663"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end</body> </html> </notes> <label text="PRR*"/> <bbox w="50.0" h="40.0" x="13904.182" y="2360.0908"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca1_s1843_wca1_wca1_csa68" compartmentRef="wca1_wca1_c5_wca1_wca1_ca9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AMER1*:CK1_gamma_*:FZD*:G_beta_*:G_gamma_*:LRP5_6*:PRR*:WNT*:_beta_-Arrestin2* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:52226983 PMID:21606194 PMID:20460648 References_end</body> </html> </notes> <label text="(Signalosome)"/> <bbox w="335.25" h="197.5" x="14206.875" y="2362.75"/> <glyph class="macromolecule" id="wca1_wca1_s1844_wca1_wca1_sa664"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="14213.375" y="2443.25"/> <glyph class="unit of information" id="_e3dc0ec0-590f-4165-8ba6-bc44f270a655"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14230.875" y="2438.25"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1844_wca1_wca1_sa666"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="14374.375" y="2444.25"/> <glyph class="unit of information" id="_8807f63d-4653-478e-9d37-e663156739ba"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14391.875" y="2439.25"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s502_wca1_wca1_sa668"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="40.0" h="20.0" x="14294.875" y="2503.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s503_wca1_wca1_sa669"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="40.0" h="20.0" x="14337.875" y="2503.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1845_wca1_wca1_sa670"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="14213.375" y="2399.25"/> <glyph class="state variable" id="_9e3d1ef9-1505-461c-beef-9b47cad0d8b1"> <state value="P" variable="T1479"/> <bbox w="40.0" h="10.0" x="14193.375" y="2419.2102"/> </glyph> <glyph class="state variable" id="_24c77216-ba4a-4d49-92fa-5707f85d4b6e"> <state value="P" variable="S1490"/> <bbox w="40.0" h="10.0" x="14233.407" y="2394.25"/> </glyph> <glyph class="state variable" id="_4a3cd0a2-eb87-4eb5-966c-48979a3dd38a"> <state value="P" variable="T1493"/> <bbox w="40.0" h="10.0" x="14273.375" y="2394.5186"/> </glyph> <glyph class="state variable" id="_f0658d9b-26d0-49aa-93b5-ec165212e55c"> <state value="P" variable="S1496"/> <bbox w="40.0" h="10.0" x="14272.757" y="2444.25"/> </glyph> <glyph class="state variable" id="_abeb2c63-1cf8-4d6d-a44f-00bd7dc8cfdb"> <state value="P" variable="T1530"/> <bbox w="40.0" h="10.0" x="14232.4795" y="2444.25"/> </glyph> <glyph class="state variable" id="_b502b853-f38a-4693-ab6a-ef900082e885"> <state value="P" variable="S1533"/> <bbox w="40.0" h="10.0" x="14193.615" y="2444.25"/> </glyph> <glyph class="unit of information" id="_de782ebd-90b3-441c-9280-526bba947cc5"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14230.875" y="2394.25"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1845_wca1_wca1_sa671"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="14374.375" y="2400.25"/> <glyph class="state variable" id="_dbfa6314-5837-4e43-b751-4ef7b2ac0b44"> <state value="P" variable="T1479"/> <bbox w="40.0" h="10.0" x="14354.375" y="2420.2102"/> </glyph> <glyph class="state variable" id="_31fc6bfc-2b32-4d04-ab42-640f6d923901"> <state value="P" variable="S1490"/> <bbox w="40.0" h="10.0" x="14394.407" y="2395.25"/> </glyph> <glyph class="state variable" id="_c78cb3fc-aa13-4082-b4be-5a7cad5ac751"> <state value="P" variable="T1493"/> <bbox w="40.0" h="10.0" x="14434.375" y="2395.5186"/> </glyph> <glyph class="state variable" id="_797b730e-d63c-479a-84f1-300d9956e5c3"> <state value="P" variable="S1496"/> <bbox w="40.0" h="10.0" x="14433.757" y="2445.25"/> </glyph> <glyph class="state variable" id="_2dec48eb-31ed-4ff0-8dfc-c53b63e6a908"> <state value="P" variable="T1530"/> <bbox w="40.0" h="10.0" x="14393.4795" y="2445.25"/> </glyph> <glyph class="state variable" id="_345bb9ee-888a-4a0c-bf5c-a0de5e651380"> <state value="P" variable="S1533"/> <bbox w="40.0" h="10.0" x="14354.615" y="2445.25"/> </glyph> <glyph class="unit of information" id="_70944f3b-51fb-4e23-8ae7-26c98eff7448"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14391.875" y="2395.25"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1846_wca1_wca1_sa672"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1γ*"/> <bbox w="80.0" h="40.0" x="14455.625" y="2444.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1846_wca1_wca1_sa673"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1γ*"/> <bbox w="80.0" h="40.0" x="14294.625" y="2442.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s936_wca1_wca1_sa674"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="14459.625" y="2491.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1847_wca1_wca1_sa675"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="14293.625" y="2402.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1847_wca1_wca1_sa676"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="14455.625" y="2402.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1848_wca1_wca1_sa677"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="14232.125" y="2382.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1848_wca1_wca1_sa678"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="14402.125" y="2382.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca1_s1418_wca1_wca1_sa679"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end</body> </html> </notes> <label text="PRR*"/> <bbox w="50.0" h="40.0" x="14226.307" y="2498.8408"/> </glyph> </glyph> <glyph class="simple chemical" id="wca1_s_wca1_s1392_wca1_wca1_sa653" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <label text="H+"/> <bbox w="25.0" h="25.0" x="14092.0" y="480.0"/> </glyph> <glyph class="simple chemical" id="wca1_s_wca1_s1654_wca1_wca1_sa652" compartmentRef="wca1_wca1_c4_wca1_wca1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re28(MAP:survival): PMID:20006983 PMID:16965538 PMID:210606194 PMID:20093472 PMID:21796133 Phosphorylation of DVL by CK1 epsilon. Activation of CK1 epsilon by unknown factor An acidic environment is required for phosphorylation of DVL and LRP5/6 References_end</body> </html> </notes> <label text="H+"/> <bbox w="25.0" h="25.0" x="14092.0" y="391.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca1_s1036_wca1_wca1_sa600" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <label text="Recycling "/> <bbox w="80.0" h="30.0" x="14118.0" y="2759.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca1_s1037_wca1_wca1_sa601" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <label text="Degradation"/> <bbox w="80.0" h="30.0" x="14218.0" y="2759.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca1_s1537_wca1_wca1_sa684" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21796133 References_end</body> </html> </notes> <label text="Renin-angiotensin system"/> <bbox w="80.0" h="30.0" x="13486.0" y="500.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca1_s1686_wca1_wca1_sa721" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re75:(MAP:survival) PMID:17925383 References_end</body> </html> </notes> <label text="Cell migration"/> <bbox w="80.0" h="30.0" x="13493.0" y="1246.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca1_s1653_wca1_wca1_sa690" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re74:(MAP:survival) PMID:21498506 PMID:17925382 References_end</body> </html> </notes> <label text="Microtubules"/> <bbox w="80.0" h="30.0" x="13182.0" y="1275.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca1_s1687_wca1_wca1_sa722" compartmentRef="wca1_wca1_c7_wca1_wca1_ca11"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re76(MAP:survival): PMID:21498506 Cell contacts has positive influence on the function of membrane bound AMER1 References_end</body> </html> </notes> <label text="Cell-cell adhesions"/> <bbox w="80.0" h="30.0" x="15182.0" y="804.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s1_wca1_wca1_sa1" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="12727.0" y="679.5"/> <glyph class="state variable" id="_a967bd85-012d-4ba0-b8ec-233d18b0443c"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="12754.404" y="714.5"/> </glyph> <glyph class="state variable" id="_4b65411b-9020-4713-b6ae-636c4fd23e76"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="12793.882" y="714.5"/> </glyph> <glyph class="state variable" id="_eb97b01b-4e1d-4c9b-a6e7-0aadd8d0f3c6"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="12794.5" y="674.7148"/> </glyph> <glyph class="state variable" id="_64b728e9-30c2-4d56-ad6b-e7f96d65d739"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="12754.532" y="674.5"/> </glyph> <glyph class="state variable" id="_788d4ddd-dc0e-4f09-925b-50ec5b8ddf6e"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="12714.992" y="674.5"/> </glyph> <glyph class="state variable" id="_0c43adb7-dc86-44fc-a12d-3847a5d38cd3"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="12714.5" y="714.2223"/> </glyph> <glyph class="state variable" id="_b22b473c-2ae7-48cc-8475-9dcf00cd05c6"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="12792.0" y="674.7148"/> </glyph> <glyph class="state variable" id="_9b3f4291-f81a-459a-b79d-5b619746a4b4"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="12792.0" y="674.7148"/> </glyph> <glyph class="state variable" id="_12c22667-f0d0-457c-a86e-6ab0f5080b2f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12722.0" y="694.5"/> </glyph> <glyph class="state variable" id="_fe69bb78-29a3-4e4f-b859-6b6768609c8a"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="12712.492" y="674.5"/> </glyph> <glyph class="state variable" id="_1fc2629a-625c-4802-a46f-2bf7cc6c6e7f"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="12792.0" y="674.7148"/> </glyph> <glyph class="state variable" id="_67c13e7f-03df-450f-be96-e91e2e1cca77"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12722.0" y="686.2157"/> </glyph> <glyph class="state variable" id="_2a47b610-ac59-48d3-8fdd-3cb2a55d6830"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="12792.0" y="674.7148"/> </glyph> <glyph class="state variable" id="_e16f962c-9a94-4ac1-ab96-a290e5bdc649"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12722.0" y="694.5"/> </glyph> <glyph class="state variable" id="_35c7cc62-fd58-488b-86bf-62785e4f3220"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="12791.382" y="714.5"/> </glyph> <glyph class="state variable" id="_a15a1d57-e70d-4ce9-9042-313323b354a6"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="12792.0" y="674.7148"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s162_wca1_wca1_sa130" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re46(MAP:survival): PMID:15688063 PMID:22730322 FAF1 acts as scaffold protein References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:TLS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15688063 References_end</body> </html> </notes> <label text="RAD6*"/> <bbox w="80.0" h="40.0" x="12797.875" y="2183.6667"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s163_wca1_wca1_sa131" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> </notes> <label text="E1*"/> <bbox w="80.0" h="40.0" x="12798.0" y="2243.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s171_wca1_wca1_sa137"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re25:(MAP:survival) PMID:21606194 PMID:19705439 s_wca2_re30(MAP:survival): Shown in Xenopus embryos that dimerisation of XFZ3 correlates with activation. This phenomenon is described once in: PMID:12734397 s_wnc1_re49(MAP:survival): PMID:20628572 PMID:12839624 s_wnc1_re62(MAP:survival): Cthrc1 enhances formation of Wnt-Fzl-Ror2 complex PMID:18606138 Syndecan-4 binds to Fzl, Dvl and is required for PCP MODULE. PMID:16604063 PMID:21397842 Vangl-2 forms complex upon binding with Wnt-5 PMID:21316585 ROR2 is associated with Wnt, Fzl and CK1_epsilon PMID:20215527 PPR binds to Fzl in both canonical and non-canonical MODULE PMID:20093472 PMID:21380625 PMID:20579883 s_wnc2_re1(MAP:survival): Wnt5 can binds to LRP5/6 and in this way, physiologically inhibits non-canonical pathway. In Xenopus and mice. PMID:19056682 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="13396.0" y="86.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s189_wca1_wca1_sa152" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re167(MAP:survival): Contains a NES PMID:15720724 s_wca1_re26(MAP:survival): PMID:16707567 PMID:21285348 DVL is primed by CK2 and/or MARK2 s_wca1_re51(MAP:survival): PMID:16547521 In the presence of WNT3a DVL-3 forms complex with KLHL12/CUL3/RBX1-complex s_wca1_re53:(MAP:survival) PMID:15852005 s_wca1_re79:(MAP:survival) PMID:11113207 PMID:18931698 s_wca3_re168(MAP:survival): contains NLS import higher when stimulated with wnt3 s_wnc1_re15:(MAP:survival) PMID:20223821 s_wnc2_re3(MAP:survival): Binding of Wnt5 and LRP5/6 leads to phosphorylation of Dvl. Most likely the same residues as picture shows same speed of migration on gel compared to Wnt3 stimulation. No phosphorylation of LRP5/6 by Wnt5. This complex formation sequesters away Wnt5 from the non-canonical pathway receptors PMID:19056682 s_wnc4_re45:(MAP:survival) PMID:17588722 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="13273.0" y="561.0"/> <glyph class="state variable" id="_5bdfc0aa-acb0-4387-a764-6004a713b976"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13348.0" y="556.0"/> </glyph> <glyph class="state variable" id="_601ae141-2fb7-4fe7-89bb-9b5ba86bff8b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13268.0" y="556.0"/> </glyph> <glyph class="state variable" id="_b937fca0-0da6-4839-9c59-760b2b1e2a84"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="13337.382" y="596.0"/> </glyph> <glyph class="state variable" id="_07e00e22-fbbb-485c-a6d4-00403804cddf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13268.0" y="556.0"/> </glyph> <glyph class="state variable" id="_e5ca6854-cd6f-445d-8ba6-7927939cef48"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13348.0" y="556.0"/> </glyph> <glyph class="state variable" id="_401d83ef-b4de-4734-8a9a-a0952898d26c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13347.634" y="556.0"/> </glyph> <glyph class="state variable" id="_36d45a0e-5001-4f49-b292-5a6e7587bf2a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13348.0" y="596.0"/> </glyph> <glyph class="state variable" id="_644ca4f6-cc9d-4013-974a-2dbdeb0205df"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="13258.0" y="595.7223"/> </glyph> <glyph class="state variable" id="_beec106b-1f1b-4e5e-a772-7d7fc4f6856c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13268.0" y="596.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s190_wca1_wca1_sa153" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re26(MAP:survival): PMID:16707567 PMID:21285348 DVL is primed by CK2 and/or MARK2 s_wca1_re29(MAP:survival): PMID:19705439 PMID:17426148 Beta-ARRESTIN binds to phosphorylated DVL References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="13411.75" y="561.0"/> <glyph class="state variable" id="_b6307aff-40bc-4eb4-8592-6339531c28b2"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="13484.25" y="556.0"/> </glyph> <glyph class="state variable" id="_d348166c-acb1-4d1c-9c75-60df91a00265"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13406.75" y="556.0"/> </glyph> <glyph class="state variable" id="_d932e8f4-b995-466a-8f6b-3139265fc371"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="13476.132" y="596.0"/> </glyph> <glyph class="state variable" id="_28c66002-cbd2-489f-a41f-15afa442db18"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13406.75" y="556.0"/> </glyph> <glyph class="state variable" id="_cab53e56-896d-4d7d-bad8-a85f4b51e48e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13486.75" y="556.0"/> </glyph> <glyph class="state variable" id="_74bc7df2-9a67-44b8-9a3d-bb8c823f7353"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13486.384" y="556.0"/> </glyph> <glyph class="state variable" id="_ac5b9340-be7c-4d26-8a25-504d63b5cf9c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13486.75" y="596.0"/> </glyph> <glyph class="state variable" id="_138f069f-bbc8-4108-94d3-cf3dab4dc4a9"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="13396.75" y="595.7223"/> </glyph> <glyph class="state variable" id="_cc74213c-3833-4fd5-a163-0f088c48be54"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13406.75" y="596.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s227_wca1_wca1_sa179" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re30(MAP:survival): PMID:19561074 PI4KIIalpha and PIP5KIbeta are in complex together with DVL. To keep complex clear the enzymes are left outside of this complex References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphatidylinositol 4-kinase type 2 alpha HUGO:PI4K2A HGNC:30031 ENTREZ:55361 UNIPROT:Q9BTU6 GENECARDS:PI4K2A REACTOME:241441 KEGG:55361 ATLASONC:GC_PI4K2A WIKI:PI4K2A phosphatidylinositol 4-kinase type 2 beta HUGO:PI4K2B HGNC:18215 ENTREZ:55300 UNIPROT:Q8TCG2 GENECARDS:PI4K2B REACTOME:241444 KEGG:55300 ATLASONC:GC_PI4K2B WIKI:PI4K2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PI4KIIalpha and PIP5KIbeta are in complex together with DVL. To keep complex clear the enzymes are left outside of this complex PMID:19561074 References_end</body> </html> </notes> <label text="PI4KIIα*"/> <bbox w="80.0" h="40.0" x="14920.0" y="567.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s228_wca1_wca1_sa180" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re31(MAP:survival): PMID:19561074 PI4KIIalpha and PIP5KIbeta are in complex together with DVL. To keep complex clear the enzymes are left outside of this complex References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphatidylinositol-4-phosphate 5-kinase type I alpha HUGO:PIP5K1A HGNC:8994 ENTREZ:8394 UNIPROT:Q99755 GENECARDS:PIP5K1A REACTOME:242739 ATLASONC:GC_PIP5K1A WIKI:PIP5K1A phosphatidylinositol-4-phosphate 5-kinase type I beta HUGO:PIP5K1B HGNC:8995 ENTREZ:8395 UNIPROT:O14986 GENECARDS:PIP5K1B REACTOME:242744 KEGG:8395 ATLASONC:GC_PIP5K1B WIKI:PIP5K1B phosphatidylinositol-4-phosphate 5-kinase type I gamma HUGO:PIP5K1C HGNC:8996 ENTREZ:23396 UNIPROT:O60331 GENECARDS:PIP5K1C REACTOME:242749 KEGG:23396 ATLASONC:GC_PIP5K1C WIKI:PIP5K1C Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19561074 References_end</body> </html> </notes> <label text="PIP5KIβ*"/> <bbox w="80.0" h="40.0" x="14912.0" y="702.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s266_wca1_wca1_sa200" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re60:(MAP:survival) PMID:21304492 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1γ*"/> <bbox w="80.0" h="40.0" x="14909.0" y="869.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s289_wca1_wca1_sa211" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re74:(MAP:survival) PMID:21498506 PMID:17925382 s_wca3_re84:(MAP:survival) PMID:10984057 s_wca1_re34(MAP:survival): PMID:21498506 Membrane-bound AMER1 acts as scaffold and brings APC to the membrane s_wca2_re64(MAP:survival): HECTD1 KO disrupts APC-AXIN interaction and augments WNT3a-induced signaling PMID:23277359 PMID:22761442 s_wca3_re75:(MAP:survival) PMID:11972058 s_wca3_re77(MAP:survival): The C-terminus of APC inhibits activity of the CK2 enzyme PMID:11972058 s_wca3_re78(MAP:survival): Site is adjacent to the NLS2 in APC PMID:11689703 s_wca3_re90:(MAP:survival) PMID:11585828 s_wnc4_re34(MAP:survival): Unknown which amino acid residue PMID:22399895 s_wnc4_re36:(MAP:survival) PMID:22898821, s_wnc4_re39(MAP:survival): Positive modulaion PMID:15755874, PMID:23308069 s_wnc4_re40:(MAP:survival) PMID:19900451 s_wnc4_re45:(MAP:survival) PMID:17588722 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="13182.0" y="1145.0"/> <glyph class="state variable" id="_674aa690-2e80-4a95-9a45-da09f4dc3356"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="13243.882" y="1180.0"/> </glyph> <glyph class="state variable" id="_bec797bb-88e6-4834-9ef9-2d39d08927d6"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="13164.992" y="1140.0"/> </glyph> <glyph class="state variable" id="_babc5680-1b44-4e5e-8b78-6ad44e9651b6"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="13244.5" y="1140.2147"/> </glyph> <glyph class="state variable" id="_975e047f-dae6-4d35-a35c-dd159028cdc4"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="13204.404" y="1180.0"/> </glyph> <glyph class="state variable" id="_361d8038-908c-4f45-a833-50450e361e12"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="13204.532" y="1140.0"/> </glyph> <glyph class="state variable" id="_5cb2abad-7968-4ee5-9eda-2b7d4416f867"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="13164.5" y="1179.7223"/> </glyph> <glyph class="state variable" id="_c8df1c9f-e3a0-4333-bb54-79698546bb93"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13257.0" y="1140.0"/> </glyph> <glyph class="state variable" id="_4ffd709d-abb4-4214-94f5-9a5f936e6344"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="13244.5" y="1179.1306"/> </glyph> <glyph class="state variable" id="_8959e166-6c9b-46c8-aa01-5ccd2489c627"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="13164.5" y="1179.7223"/> </glyph> <glyph class="state variable" id="_75c4d918-54fb-4c3c-a131-62c0fd293e84"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13169.992" y="1140.0"/> </glyph> <glyph class="state variable" id="_a58ca5f1-abf9-4738-bd8c-119d2098120b"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="13164.992" y="1140.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s405_wca1_wca1_sa300" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca2_re52:(MAP:survival) PMID:19244247 s_wca1_re39:(MAP:survival) PMID:21606194 s_wca2_re51:(MAP:survival) PMID:21152425 PMID:19244247 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="13428.0" y="1136.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s406_wca1_wca1_sa301" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re39:(MAP:survival) PMID:21606194 s_wca2_re7(MAP:survival): The protein is Parsylated but cannot be depicted as such in the program. Glutamic acids are parsylated. PMID:17825467 Both TNKS are required for parsylation of AXIN1/2 PMID:19759537 PMID:21799911 s_wnc4_re32:(MAP:survival) PMID:16868183 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="13568.0" y="1136.0"/> <glyph class="state variable" id="_3af1bafa-fc84-4180-a07d-21fbaeea586b"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="13555.992" y="1131.0"/> </glyph> <glyph class="state variable" id="_7141a31a-a31e-40f1-8057-0f1e0930e43a"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="13595.532" y="1131.0"/> </glyph> <glyph class="state variable" id="_82475b37-43c5-4735-8184-634990bf3004"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="13633.0" y="1131.2147"/> </glyph> <glyph class="state variable" id="_d33af3ea-50e7-439b-a95a-0137dae1daae"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="13632.382" y="1171.0"/> </glyph> <glyph class="state variable" id="_d289e3fc-8034-4464-ab71-0908463888e3"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="13592.904" y="1171.0"/> </glyph> <glyph class="state variable" id="_6ba0a305-1b61-4e5c-b7f9-7c7c8cb1f7d7"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="13553.0" y="1170.7223"/> </glyph> <glyph class="state variable" id="_38a98d00-9307-4da9-bfd6-62ffccc850ec"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="13595.404" y="1171.0"/> </glyph> <glyph class="state variable" id="_f8c1a143-ea2b-4ddc-bc87-2dca30d794c6"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="13634.882" y="1171.0"/> </glyph> <glyph class="state variable" id="_5e9cfcd3-099f-4ed1-8542-d03d87dbc357"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="13640.5" y="1131.2147"/> </glyph> <glyph class="state variable" id="_6d1315c5-cea5-41f6-b15a-a3a7eae7c438"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13555.5" y="1170.7223"/> </glyph> <glyph class="state variable" id="_f99d849c-2228-4f24-9525-ed80d8cc8d04"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="13560.992" y="1131.0"/> </glyph> <glyph class="state variable" id="_a91ebc60-e054-4048-9c12-20567e491ab1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13563.0" y="1131.0"/> </glyph> <glyph class="state variable" id="_910431f2-7e5a-4144-94c1-c9050c9aff3e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13643.0" y="1131.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s483_wca1_wca1_sa382" compartmentRef="wca1_wca1_c5_wca1_wca1_ca9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re42:(MAP:survival) PMID:21606194 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="53.0" h="123.0" x="14863.5" y="2431.0"/> <glyph class="state variable" id="_4dee0df0-57c4-4a84-b46a-08c1f5277543"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14909.0" y="2426.0"/> </glyph> <glyph class="state variable" id="_cb316a66-34ba-40e2-ba72-90ff1247bad7"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="14849.345" y="2426.0"/> </glyph> <glyph class="state variable" id="_ab9e2237-ce72-4a19-ad5a-b234fe4957bf"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="14901.5" y="2426.6604"/> </glyph> <glyph class="state variable" id="_6e475b03-8ade-4a53-8b06-29d442795c35"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="14899.569" y="2549.0"/> </glyph> <glyph class="state variable" id="_6de19764-bf5e-48a7-9f61-8339aaf2309a"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="14848.659" y="2549.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s490_wca1_wca1_sa63" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re19:(MAP:survival) PMID:17318175 s_wnc2_re46(MAP:survival): Upon Ca2+ activation the NRON-NFAT complex dissociates. PMID:21709260 s_wca1_re39:(MAP:survival) PMID:21606194 s_wnc1_re44(MAP:survival): PKA phosphorylates first Thr1548? followed by GSK3 at S1544 PMID:21406690 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="12911.25" y="464.5"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s562_wca1_wca1_sa435" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re46(MAP:survival): PMID:15688063 PMID:22730322 FAF1 acts as scaffold protein References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: neural precursor cell expressed developmentally down-regulated 8 HUGO:NEDD8 HGNC:7732 ENTREZ:4738 UNIPROT:Q15843 GENECARDS:NEDD8 KEGG:4738 ATLASONC:GC_NEDD8 WIKI:NEDD8 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:NER MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15688063 PMID:19576224 References_end</body> </html> </notes> <label text="NEDD8"/> <bbox w="80.0" h="40.0" x="12798.0" y="2124.3333"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s654_wca1_wca1_sa492" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re49:(MAP:survival) PMID:19576224 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="13166.25" y="1615.0"/> <glyph class="state variable" id="_00fad768-022e-4e71-9f01-9985bf763af9"> <state value="P" variable="S45"/> <bbox w="30.0" h="10.0" x="13191.154" y="1650.0"/> </glyph> <glyph class="state variable" id="_44f4f38a-7427-4f36-89fd-5f850cc49156"> <state value="P" variable="T41"/> <bbox w="30.0" h="10.0" x="13230.632" y="1650.0"/> </glyph> <glyph class="state variable" id="_dbc0c7fe-893f-4c5c-a289-69733c00d5fb"> <state value="P" variable="S37"/> <bbox w="30.0" h="10.0" x="13231.25" y="1610.2147"/> </glyph> <glyph class="state variable" id="_0bc39836-8497-4035-be5b-9753a409401b"> <state value="P" variable="S33"/> <bbox w="30.0" h="10.0" x="13191.282" y="1610.0"/> </glyph> <glyph class="state variable" id="_86a19762-bbea-469f-9e51-ee4bf5ae2922"> <state value="Ub" variable="K19"/> <bbox w="35.0" h="10.0" x="13149.242" y="1610.0"/> </glyph> <glyph class="state variable" id="_da1fca78-1cd1-4da2-a761-63cb6200b222"> <state value="Ub" variable="K49"/> <bbox w="35.0" h="10.0" x="13148.75" y="1649.7223"/> </glyph> <glyph class="state variable" id="_6f8fd123-4da2-4b5d-9126-a198331934c1"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="13231.25" y="1610.2147"/> </glyph> <glyph class="state variable" id="_8de8e5c5-4402-4cf5-8ef4-630ecd47dd2b"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="13231.25" y="1610.2147"/> </glyph> <glyph class="state variable" id="_d3a6cbf5-7a3a-4877-9061-120d399d1ba1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13161.25" y="1630.0"/> </glyph> <glyph class="state variable" id="_c3d66530-a473-4acc-9e23-632300e8cd32"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="13151.742" y="1610.0"/> </glyph> <glyph class="state variable" id="_2e274aad-f3e6-4a65-b375-0465bea67bd2"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="13231.25" y="1610.2147"/> </glyph> <glyph class="state variable" id="_ffddeb4e-23f5-49db-9796-d1e4cc5d8dac"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13161.25" y="1621.7157"/> </glyph> <glyph class="state variable" id="_916061df-8aef-481f-ad40-bf9b22cbbabd"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="13231.25" y="1610.2147"/> </glyph> <glyph class="state variable" id="_702b61b1-7788-404e-a366-06b3f49b43a7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13161.25" y="1630.0"/> </glyph> <glyph class="state variable" id="_797bfab3-2427-4aec-a391-418d0b01ef78"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="13230.632" y="1650.0"/> </glyph> <glyph class="state variable" id="_2e70f7de-5967-4405-a313-290bb59e908f"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="13231.25" y="1610.2147"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s655_wca1_wca1_sa493" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re16:(MAP:survival) PMID:17318175 PMID:19581931 s_wca1_re33(MAP:survival): PMID:19561074 PMID:20460648 PMID:19581931 PMID:21304492 PMID:21498506 AMER1 recruits axin References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: disabled homolog 1 (Drosophila) HUGO:DAB1 HGNC:2661 ENTREZ:1600 UNIPROT:O75553 GENECARDS:DAB1 KEGG:352909 ATLASONC:GC_DAB1 WIKI:DAB1 disabled homolog 2 mitogen-responsive phosphoprotein (Drosophila) HUGO:DAB2 HGNC:2662 ENTREZ:1601 UNIPROT:P98082 GENECARDS:DAB2 REACTOME:404974 KEGG:1601 ATLASONC:DAB2ID40258ch5p13 WIKI:DAB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15518237 References_end</body> </html> </notes> <label text="DAB2"/> <bbox w="80.0" h="40.0" x="13222.25" y="924.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s732_wca1_wca1_sa530" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HECT C2 and WW domain containing E3 ubiquitin protein ligase 1 HUGO:HECW1 HGNC:22195 ENTREZ:23072 UNIPROT:Q76N89 GENECARDS:HECW1 KEGG:23072 ATLASONC:GC_HECW1 WIKI:HECW1 HECT C2 and WW domain containing E3 ubiquitin protein ligase 2 HUGO:HECW2 HGNC:29853 ENTREZ:57520 UNIPROT:Q9P2P5 GENECARDS:HECW2 KEGG:57520 ATLASONC:GC_HECW2 WIKI:HECW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18223681 PMID:14684739 References_end</body> </html> </notes> <label text="NEDL1*"/> <bbox w="80.0" h="40.0" x="13198.0" y="1407.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s733_wca1_wca1_sa531" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re53:(MAP:survival) PMID:15852005 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: inversin HUGO:INVS HGNC:17870 ENTREZ:27130 UNIPROT:Q9Y283 GENECARDS:INVS KEGG:27130 WIKI:INVS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15852005 References_end</body> </html> </notes> <label text="Iversin*"/> <bbox w="80.0" h="40.0" x="12719.0" y="1183.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s757_wca1_wca1_sa537" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Abelson helper integration site 1 HUGO:AHI1 HGNC:21575 ENTREZ:54806 UNIPROT:Q8N157 GENECARDS:AHI1 KEGG:54806 ATLASONC:GC_AHI1 WIKI:AHI1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19718039 PMID:21602792 References_end</body> </html> </notes> <label text="JBN*"/> <bbox w="80.0" h="40.0" x="12992.0" y="1084.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s767_wca1_wca1_sa544" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Dynein cytoplasmic 2 heavy chain 1 HUGO:DYNC2H1 HGNC:2962 ENTREZ:79659 UNIPROT:Q8NCM8 GENECARDS:DYNC2H1 REACTOME:227754 KEGG:79659 ATLASONC:GC_DYNC2H1 WIKI:DYNC2H1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21209331 References_end Identifiers_begin: Dynein cytoplasmic 2 heavy chain 1 HUGO:DYNC2H1 HGNC:2962 ENTREZ:79659 UNIPROT:Q8NCM8 GENECARDS:DYNC2H1 REACTOME:227754 KEGG:79659 ATLASONC:GC_DYNC2H1 WIKI:DYNC2H1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21209331 References_end</body> </html> </notes> <label text="DYNC2H1"/> <bbox w="80.0" h="40.0" x="12831.0" y="682.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s783_wca1_wca1_sa545" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re46(MAP:survival): PMID:15688063 PMID:22730322 FAF1 acts as scaffold protein References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Fas (TNFRSF6) associated factor 1 HUGO:FAF1 HGNC:3578 ENTREZ:11124 UNIPROT:Q9UNN5 GENECARDS:FAF1 KEGG:11124 ATLASONC:GC_FAF1 WIKI:FAF1 Fas associated factor family member 2 HUGO:FAF2 HGNC:24666 ENTREZ:23197 UNIPROT:Q96CS3 GENECARDS:FAF2 KEGG:23197 WIKI:FAF2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19597341 References_end</body> </html> </notes> <label text="FAF*"/> <bbox w="80.0" h="40.0" x="12916.0" y="2247.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s885_wca1_wca1_sa552" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re26(MAP:survival): PMID:16707567 PMID:21285348 DVL is primed by CK2 and/or MARK2 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: MAP/microtubule affinity-regulating kinase 2 HUGO:MARK2 HGNC:3332 ENTREZ:2011 UNIPROT:Q7KZI7 GENECARDS:MARK2 KEGG:2011 ATLASONC:GC_MARK2 WIKI:MARK2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17721078 References_end</body> </html> </notes> <label text="MARK2"/> <bbox w="80.0" h="40.0" x="13342.0" y="504.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s886_wca1_wca1_sa553" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="13466.0" y="719.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s970_wca1_wca1_sa574" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re34(MAP:survival): PMID:21498506 Membrane-bound AMER1 acts as scaffold and brings APC to the membrane s_wca1_re59:(MAP:survival) PMID:21304492 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: family with sequence similarity 123B HUGO:FAM123B GENECARDS:FAM123B KEGG:139285 WIKI:FAM123B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20843316 References_end</body> </html> </notes> <label text="AMER1*"/> <bbox w="80.0" h="40.0" x="14904.0" y="779.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s1192_wca1_wca1_sa626" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re67:(MAP:survival) PMID:20562099 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: HUGO:RGS19 HGNC:13735 ENTREZ:10287 UNIPROT:P49795 GENECARDS:RGS19 REACTOME:63040 KEGG:10287 ATLASONC:GC_RGS19 WIKI:RGS19 regulator of G-protein signaling 20 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12011974 References_end</body> </html> </notes> <label text="RGS19"/> <bbox w="80.0" h="40.0" x="13538.0" y="836.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s1370_wca1_wca1_sa648" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re25:(MAP:survival) PMID:21606194 PMID:19705439 s_wnc1_re62(MAP:survival): Cthrc1 enhances formation of Wnt-Fzl-Ror2 complex PMID:12839624 PMID:18606138 Syndecan-4 binds to Fzl, Dvl and is required for PCP MODULE. PMID:16604063 PMID:21397842 Vangl-2 forms complex upon binding with Wnt-5 PMID:21316585 ROR2 is associated with Wnt, Fzl and CK1_epsilon PMID:20215527 PPR binds to Fzl in both canonical and non-canonical MODULE PMID:20093472 PMID:21380625 PMID:20579883 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end Identifiers_begin: ATPase H+ transporting lysosomal accessory protein 2 HUGO:ATP6AP2 HGNC:18305 ENTREZ:10159 UNIPROT:O75787 GENECARDS:ATP6AP2 REACTOME:67126 KEGG:10159 ATLASONC:GC_ATP6AP2 WIKI:ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 1 ATP6IP1, ATP6S1, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1" HUGO:ATP6AP1 HGNC:868 ENTREZ:537 UNIPROT:Q15904 GENECARDS:ATP6AP1 KEGG:537 ATLASONC:GC_ATP6AP1 WIKI:ATP6AP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to Fz8 and LRP6 PMID:21087212 References_end</body> </html> </notes> <label text="PRR*"/> <bbox w="50.0" h="40.0" x="13425.0" y="371.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s1536_wca1_wca1_sa665" compartmentRef="wca1_wca1_c5_wca1_wca1_ca9"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="14134.125" y="2596.25"/> <glyph class="state variable" id="_4edbff57-fef3-48ee-95eb-6caa5367d1af"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14206.625" y="2591.25"/> </glyph> <glyph class="state variable" id="_f38cc19f-fe97-4873-aa0e-e8364fa0f7ee"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14126.625" y="2591.25"/> </glyph> <glyph class="state variable" id="_95a6ee59-24c7-4a8e-bd11-d42dbb828d64"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="14198.507" y="2631.25"/> </glyph> <glyph class="state variable" id="_e92348bc-13db-4908-9a1a-0c96dbc5dfd1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14129.125" y="2591.25"/> </glyph> <glyph class="state variable" id="_c8f75319-39be-44ac-8731-478bd6fc98a1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14209.125" y="2591.25"/> </glyph> <glyph class="state variable" id="_f549fd53-a2c6-49be-a91d-7f6e1120a173"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14208.759" y="2591.25"/> </glyph> <glyph class="state variable" id="_6f3b3283-62a0-4e56-afa2-5cbdb715f286"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14209.125" y="2631.25"/> </glyph> <glyph class="state variable" id="_ff60633d-6b55-4d3e-a569-dd41806ae7b0"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="14119.125" y="2630.9724"/> </glyph> <glyph class="state variable" id="_85babbb0-55ba-44a9-9523-93528adda49a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14129.125" y="2631.25"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s1691_wca1_wca1_sa725" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re77(MAP:survival): PMID:22100263 5T4 forms complex with LRP6 resulting in inhibition of the canonical wnt References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: trophoblast glycoprotein HUGO:TPBG HGNC:12004 ENTREZ:7162 UNIPROT:Q13641 GENECARDS:TPBG KEGG:7162 ATLASONC:GC_TPBG WIKI:TPBG Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: It's a glycoprotein and is produced during embryogenesis PMID:17484803 References_end</body> </html> </notes> <label text="5T4*"/> <bbox w="80.0" h="40.0" x="14925.0" y="1224.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s1698_wca1_wca1_sa730" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re79:(MAP:survival) PMID:11113207 PMID:18931698 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: CXXC finger protein 4 HUGO:CXXC4 HGNC:24593 ENTREZ:80319 UNIPROT:Q9H2H0 GENECARDS:CXXC4 KEGG:80319 ATLASONC:GC_CXXC4 WIKI:CXXC4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11113207 References_end</body> </html> </notes> <label text="IDAX*"/> <bbox w="80.0" h="40.0" x="13101.0" y="423.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s1849_wca1_wca1_sa650" compartmentRef="wca1_wca1_c4_wca1_wca1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re68(MAP:survival): PMID:20093472 PRR binds to subunits ATP6V0C and D those are subunits of the V-ATPase. References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATPase H+ transporting lysosomal 16kDa V0 subunit c HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATPase H+ transporting lysosomal 38kDa V0 subunit d1 HUGO:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 GENECARDS:ATP6V0D1 REACTOME:67070 KEGG:9114 WIKI:ATP6V0D1 ATPase H+ transporting lysosomal 38kDa V0 subunit d2 HUGO/ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 HUGO:ATP6VOC GENECARDS:ATP6VOC WIKI:ATP6VOC HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATP6D, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d isoform 1", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit D1" HUOG:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 HUGO:ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 GENECARDS:ATP6V0D2 REACTOME:254033 KEGG:245972 WIKI:ATP6V0D2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20093472 References_end Identifiers_begin: ATPase H+ transporting lysosomal 16kDa V0 subunit c HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATPase H+ transporting lysosomal 38kDa V0 subunit d1 HUGO:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 GENECARDS:ATP6V0D1 REACTOME:67070 KEGG:9114 WIKI:ATP6V0D1 ATPase H+ transporting lysosomal 38kDa V0 subunit d2 HUGO/ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 HUGO:ATP6VOC GENECARDS:ATP6VOC WIKI:ATP6VOC HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATP6D, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d isoform 1", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit D1" HUOG:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 HUGO:ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 GENECARDS:ATP6V0D2 REACTOME:254033 KEGG:245972 WIKI:ATP6V0D2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20093472 References_end</body> </html> </notes> <label text="ATP6V0C_D*"/> <clone/> <bbox w="80.0" h="40.0" x="13885.0" y="428.0"/> <glyph class="unit of information" id="_73dcdbcd-4b1d-4c40-894d-1a2d4362f294"> <label text="ion channel"/> <bbox w="60.0" h="10.0" x="13895.0" y="423.0"/> </glyph> <glyph class="state variable" id="_edfbd2b5-4ed0-4802-99c4-2d1ade45afef"> <state value="closed" variable=""/> <bbox w="40.0" h="10.0" x="13905.0" y="463.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s1849_wca1_wca1_sa651" compartmentRef="wca1_wca1_c4_wca1_wca1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re68(MAP:survival): PMID:20093472 PRR binds to subunits ATP6V0C and D those are subunits of the V-ATPase. References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ATPase H+ transporting lysosomal 16kDa V0 subunit c HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATPase H+ transporting lysosomal 38kDa V0 subunit d1 HUGO:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 GENECARDS:ATP6V0D1 REACTOME:67070 KEGG:9114 WIKI:ATP6V0D1 ATPase H+ transporting lysosomal 38kDa V0 subunit d2 HUGO/ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 HUGO:ATP6VOC GENECARDS:ATP6VOC WIKI:ATP6VOC HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATP6D, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d isoform 1", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit D1" HUOG:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 HUGO:ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 GENECARDS:ATP6V0D2 REACTOME:254033 KEGG:245972 WIKI:ATP6V0D2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20093472 References_end Identifiers_begin: ATPase H+ transporting lysosomal 16kDa V0 subunit c HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATPase H+ transporting lysosomal 38kDa V0 subunit d1 HUGO:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 GENECARDS:ATP6V0D1 REACTOME:67070 KEGG:9114 WIKI:ATP6V0D1 ATPase H+ transporting lysosomal 38kDa V0 subunit d2 HUGO/ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 HUGO:ATP6VOC GENECARDS:ATP6VOC WIKI:ATP6VOC HUGO:ATP6V0C HGNC:855 ENTREZ:527 UNIPROT:P27449 GENECARDS:ATP6V0C REACTOME:67124 KEGG:527 ATLASONC:GC_ATP6V0C WIKI:ATP6V0C ATP6D, "ATPase, H+ transporting, lysosomal (vacuolar proton pump), member D", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d isoform 1", "ATPase, H+ transporting, lysosomal 38kDa, V0 subunit D1" HUOG:ATP6V0D1 HGNC:13724 ENTREZ:9114 UNIPROT:P61421 HUGO:ATP6V0D2 HGNC:18266 ENTREZ:245972 UNIPROT:Q8N8Y2 GENECARDS:ATP6V0D2 REACTOME:254033 KEGG:245972 WIKI:ATP6V0D2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20093472 References_end</body> </html> </notes> <label text="ATP6V0C_D*"/> <clone/> <bbox w="80.0" h="40.0" x="14048.0" y="428.0"/> <glyph class="unit of information" id="_b1972174-e442-489f-a016-0d72d44e6db5"> <label text="ion channel"/> <bbox w="60.0" h="10.0" x="14058.0" y="423.0"/> </glyph> <glyph class="state variable" id="_c0f482d5-8490-484f-a910-320f7fd327e4"> <state value="open" variable=""/> <bbox w="30.0" h="10.0" x="14073.0" y="463.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca1_s1850_wca1_wca1_sa733" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca2_re21(MAP:survival): DKK1 can disrupt binding of Fz/LRP6/WNT complex PMID:11448771 s_wca1_re77(MAP:survival): PMID:22100263 5T4 forms complex with LRP6 resulting in inhibition of the canonical wnt s_wca2_re20(MAP:survival): PMID:11433302 PMID:12050670 s_wnc2_re1(MAP:survival): Wnt5 can binds to LRP5/6 and in this way, physiologically inhibits non-canonical pathway. In Xenopus and mice. PMID:19056682 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="15030.375" y="1122.0"/> <glyph class="state variable" id="_693b8bae-8cf0-47f6-95c7-a6ebcff1935a"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="15012.875" y="1141.9602"/> </glyph> <glyph class="state variable" id="_2b9ce9e9-9bea-4cb2-8fcb-d05e1b502a40"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="15052.907" y="1117.0"/> </glyph> <glyph class="state variable" id="_9abdc3e5-03a9-4cd8-8035-ce2281472dec"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="15092.875" y="1117.2684"/> </glyph> <glyph class="state variable" id="_404a0d64-0215-408a-acf0-81a183a7255d"> <state value="" variable="S1496"/> <bbox w="35.0" h="10.0" x="15092.257" y="1167.0"/> </glyph> <glyph class="state variable" id="_b609b978-1963-4391-bf1a-b7a875c76f46"> <state value="" variable="T1530"/> <bbox w="35.0" h="10.0" x="15051.9795" y="1167.0"/> </glyph> <glyph class="state variable" id="_24395e1d-0df1-4c8e-a3f8-20a76e9d4049"> <state value="" variable="S1533"/> <bbox w="35.0" h="10.0" x="15013.115" y="1167.0"/> </glyph> <glyph class="unit of information" id="_8d47daf2-de7d-49ac-a560-fcd9703375fa"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="15047.875" y="1117.0"/> </glyph> </glyph> <glyph class="simple chemical" id="wca1_s_wca1_s220_wca1_wca1_sa174" compartmentRef="wca1_wca1_c4_wca1_wca1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re25:(MAP:survival) PMID:21606194 PMID:19705439 References_end</body> </html> </notes> <label text="GTP"/> <bbox w="25.0" h="25.0" x="13568.5" y="331.0"/> </glyph> <glyph class="simple chemical" id="wca1_s_wca1_s221_wca1_wca1_sa175" compartmentRef="wca1_wca1_c4_wca1_wca1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re25:(MAP:survival) PMID:21606194 PMID:19705439 References_end</body> </html> </notes> <label text="GDP"/> <bbox w="25.0" h="25.0" x="13740.5" y="331.0"/> </glyph> <glyph class="simple chemical" id="wca1_s_wca1_s229_wca1_wca1_sa181" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re30(MAP:survival): PMID:19561074 PI4KIIalpha and PIP5KIbeta are in complex together with DVL. To keep complex clear the enzymes are left outside of this complex References_end</body> </html> </notes> <label text="PtdIns"/> <bbox w="70.0" h="25.0" x="15025.0" y="484.5"/> </glyph> <glyph class="simple chemical" id="wca1_s_wca1_s230_wca1_wca1_sa182" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re30(MAP:survival): PMID:19561074 PI4KIIalpha and PIP5KIbeta are in complex together with DVL. To keep complex clear the enzymes are left outside of this complex s_wca1_re31(MAP:survival): References_end</body> </html> </notes> <label text="PtdIns(4)-P"/> <bbox w="70.0" h="25.0" x="15031.0" y="583.5"/> </glyph> <glyph class="simple chemical" id="wca1_s_wca1_s1191_wca1_wca1_sa625" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re67:(MAP:survival) PMID:20562099 s_wnc1_re51(MAP:survival): PMID:20628572 RGS3 and RGS14 are GTP-ase activating proteins for Gi_alpha and Gq_alpha. PMID:10999941 PMID:12534294 References_end</body> </html> </notes> <label text="Pi"/> <bbox w="25.0" h="25.0" x="13775.5" y="784.5"/> </glyph> <glyph class="phenotype" id="wca1_s_wca1_s1697_wca1_wca1_sa729" compartmentRef="wca1_wca1_c7_wca1_wca1_ca11"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re78:(MAP:survival) PMID:22100263 References_end</body> </html> </notes> <label text="WNT non canonical pathway"/> <bbox w="80.0" h="30.0" x="15197.0" y="1347.0"/> </glyph> <glyph class="simple chemical" id="wca1_s_wca1_s231_wca1_wca1_sa183" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re31(MAP:survival): PMID:19561074 PI4KIIalpha and PIP5KIbeta are in complex together with DVL. To keep complex clear the enzymes are left outside of this complex s_wca1_re59:(MAP:survival) PMID:21304492 References_end</body> </html> </notes> <label text="PtdIns(4,5)-P2"/> <bbox w="70.0" h="25.0" x="15033.0" y="699.5"/> </glyph> <glyph class="unspecified entity" id="wca1_s_wca1_s156_wca1_wca1_sa125" compartmentRef="wca1_wca1_c1_wca1_wca1_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca1_re12:(MAP:survival) PMID:10581160 References_end</body> </html> </notes> <label text="Unknown kinase"/> <bbox w="70.0" h="25.0" x="12588.0" y="490.5"/> </glyph> <glyph class="unspecified entity" id="wca1_s_wca2_s309_wca1_wca2_sa207" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Unknown enzyme"/> <bbox w="70.0" h="25.0" x="17484.0" y="1914.5"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s1_wca1_wca2_sa1" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re1:(MAP:survival) PMID:21490931 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: naked cuticle homolog 1 (Drosophila)- HUGO:NKD1 HGNC:17045 ENTREZ:85407 UNIPROT:Q969G9 GENECARDS:NKD1 KEGG:85407 ATLASONC:GC_NKD1 WIKI:NKD1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21490931 References_end</body> </html> </notes> <label text="NKD1"/> <bbox w="80.0" h="40.0" x="15724.0" y="761.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s2_wca1_wca2_sa2" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re2:(MAP:survival) PMID:21490931 s_wca2_re58(MAP:survival): DVL and RIPK4 form constitutively a complex PMID:23371553 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dishevelled dsh homolog 2 (Drosophila) "dishevelled 2 (homologous to Drosophila dsh)" HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:16273260 References_end</body> </html> </notes> <label text="DVL2"/> <bbox w="80.0" h="40.0" x="15876.25" y="913.0"/> <glyph class="state variable" id="_bbf4bab4-e0ef-4815-8f8c-166a1dd5d962"> <state value="" variable="S480"/> <bbox w="30.0" h="10.0" x="15861.742" y="908.0"/> </glyph> <glyph class="state variable" id="_2fe48a4a-ad7a-47db-80fe-093bc909e055"> <state value="" variable="S298"/> <bbox w="30.0" h="10.0" x="15861.25" y="947.7223"/> </glyph> <glyph class="state variable" id="_96a1ebb1-7f10-40e3-ad34-642937fab84a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15951.25" y="908.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s3_wca1_wca2_sa3" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="15734.0" y="919.86597"/> <glyph class="state variable" id="_569df7d6-7817-4b4d-8d34-92dabb8140e3"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="15761.404" y="954.86597"/> </glyph> <glyph class="state variable" id="_64141550-ea35-4b44-ac26-0cafb8f635cc"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="15800.882" y="954.86597"/> </glyph> <glyph class="state variable" id="_58f74653-f3ef-4319-a3e7-e5c38b5a8e6a"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="15801.5" y="915.08075"/> </glyph> <glyph class="state variable" id="_216612c3-bf25-4c4b-bfc1-a717d1b509a6"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="15761.532" y="914.86597"/> </glyph> <glyph class="state variable" id="_69e479e1-7915-462d-86bb-5e0c9dd07c20"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="15721.992" y="914.86597"/> </glyph> <glyph class="state variable" id="_e0835e8f-f732-46ac-8954-ba9054b4fe35"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="15721.5" y="954.58826"/> </glyph> <glyph class="state variable" id="_459fb8b9-048d-4814-9b86-7bfb795503b9"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="15799.0" y="915.08075"/> </glyph> <glyph class="state variable" id="_f4e318aa-9489-44a0-9f66-6ebb80675fe7"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="15799.0" y="915.08075"/> </glyph> <glyph class="state variable" id="_34ca9ce8-64fa-46c5-ba09-b6c654fc094e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15729.0" y="934.86597"/> </glyph> <glyph class="state variable" id="_1a14fe87-4aef-4daf-8fcf-b270012fd97b"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="15719.492" y="914.86597"/> </glyph> <glyph class="state variable" id="_4f745cbb-2808-4a36-8d49-e89fcae57d67"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="15799.0" y="915.08075"/> </glyph> <glyph class="state variable" id="_4cedbf1b-6c0c-4d64-a1a2-f3c787156651"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15729.0" y="926.58167"/> </glyph> <glyph class="state variable" id="_24402c3b-1fae-4261-9362-aa53b85d7623"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="15799.0" y="915.08075"/> </glyph> <glyph class="state variable" id="_f81d9c3f-1e8f-4fa9-99b0-505a26d5524b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15729.0" y="934.86597"/> </glyph> <glyph class="state variable" id="_7c5e9a14-ecbf-4df6-8b5e-d71b5b359f55"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="15798.382" y="954.86597"/> </glyph> <glyph class="state variable" id="_45964e0c-25b5-4fff-b61e-3762f7e8fc9b"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="15799.0" y="915.08075"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s21_wca1_wca2_sa18" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="16912.0" y="1207.0"/> <glyph class="state variable" id="_1f674303-9f28-45f8-b926-bb542c075dcf"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="16899.992" y="1202.0"/> </glyph> <glyph class="state variable" id="_a3e18311-be0e-4eda-9aa1-4ff5f4c1908c"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="16939.531" y="1202.0"/> </glyph> <glyph class="state variable" id="_e66e44a8-6b0d-48ad-9015-935210e05e0a"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="16977.0" y="1202.2147"/> </glyph> <glyph class="state variable" id="_e613f38b-d613-4452-8b49-fc95fb2e36d6"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="16976.38" y="1242.0"/> </glyph> <glyph class="state variable" id="_7ff8b3e4-e488-478b-86f9-bd28c51a3a33"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="16936.904" y="1242.0"/> </glyph> <glyph class="state variable" id="_3dd6fc41-073e-454a-b1c8-31821a6de162"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="16897.0" y="1241.7223"/> </glyph> <glyph class="state variable" id="_cbe16032-99a4-43b2-8834-ba5564fc23fb"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="16939.404" y="1242.0"/> </glyph> <glyph class="state variable" id="_08047146-3fcf-4899-880d-dd2e1b40c720"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="16978.88" y="1242.0"/> </glyph> <glyph class="state variable" id="_7cc05caf-0514-4e58-a398-cfd4b8bf6dfb"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="16984.5" y="1202.2147"/> </glyph> <glyph class="state variable" id="_bbd3c2cf-a786-4d26-9656-841336aa1c03"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="16899.5" y="1241.7223"/> </glyph> <glyph class="state variable" id="_b2a4fe52-ae5b-4f7d-8aeb-2ec51b2a10e2"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="16904.992" y="1202.0"/> </glyph> <glyph class="state variable" id="_15efef64-484a-4473-b90f-cfa71e1ff087"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16907.0" y="1202.0"/> </glyph> <glyph class="state variable" id="_ff04744b-029f-4b24-ba05-584da0227af8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16987.0" y="1202.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s22_wca1_wca2_sa19" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: ?=parsylated s_wca2_re7(MAP:survival): The protein is Parsylated but cannot be depicted as such in the program. Glutamic acids are parsylated. PMID:17825467 Both TNKS are required for parsylation of AXIN1/2 PMID:19759537 PMID:21799911 s_wca2_re8(MAP:survival): PMID:21478859 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="17094.0" y="1207.0"/> <glyph class="state variable" id="_03180c4c-63f6-4157-8879-a1207d4ca007"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="17081.992" y="1202.0"/> </glyph> <glyph class="state variable" id="_93ffe30b-e97c-4e12-a14d-b4479f86bcd9"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="17121.531" y="1202.0"/> </glyph> <glyph class="state variable" id="_c5faf6da-7832-4312-aa7a-9d8ef87cbce2"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="17159.0" y="1202.2147"/> </glyph> <glyph class="state variable" id="_96739d8d-07a0-41c3-94c4-756afd1da13c"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="17158.38" y="1242.0"/> </glyph> <glyph class="state variable" id="_a84140b4-27f3-44a9-96b2-c534691cd3dc"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="17118.904" y="1242.0"/> </glyph> <glyph class="state variable" id="_38d37c6b-646d-4778-b4e2-0a98697e2bd0"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="17079.0" y="1241.7223"/> </glyph> <glyph class="state variable" id="_4dfdeb00-cdc6-4da3-962d-fe96185269c6"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="17121.404" y="1242.0"/> </glyph> <glyph class="state variable" id="_ff6bd914-3cd0-4866-8b03-dd2830ce6788"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="17160.88" y="1242.0"/> </glyph> <glyph class="state variable" id="_641fdf04-4d5b-43dc-8e44-fd153989dde2"> <state value="?" variable="E"/> <bbox w="20.0" h="10.0" x="17164.0" y="1202.2147"/> </glyph> <glyph class="state variable" id="_0130cc40-2174-45b6-9324-1d2942e9f1cf"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="17081.5" y="1241.7223"/> </glyph> <glyph class="state variable" id="_b1dfbbb6-4b87-450d-bde6-544c765a8093"> <state value="?" variable="E"/> <bbox w="20.0" h="10.0" x="17084.492" y="1202.0"/> </glyph> <glyph class="state variable" id="_f157f779-e5ac-469d-897e-d2d68a24f7d5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="17089.0" y="1202.0"/> </glyph> <glyph class="state variable" id="_87c3eafa-9013-4fe3-be3f-8396e9828252"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="17169.0" y="1202.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s23_wca1_wca2_sa20" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re7(MAP:survival): The protein is Parsylated but cannot be depicted as such in the program. Glutamic acids are parsylated. PMID:17825467 Both TNKS are required for parsylation of AXIN1/2 PMID:19759537 PMID:21799911 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tankyrase TRF1-interacting ankyrin-related ADP-ribose polymerase HUGO:TNKS HGNC:11941 ENTREZ:8658 UNIPROT:O95271 GENECARDS:TNKS KEGG:8658 ATLASONC:TNKSID43534ch8p23 WIKI:TNKS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22154485 References_end</body> </html> </notes> <label text="TNKS1*"/> <bbox w="80.0" h="40.0" x="17003.0" y="1115.0"/> <glyph class="state variable" id="_af23ebda-fc7b-46a2-b755-822474865231"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="17078.0" y="1110.0"/> </glyph> <glyph class="state variable" id="_46729108-f5d5-47ba-8d43-b1aba4f377ba"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16998.0" y="1110.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s24_wca1_wca2_sa21" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re7(MAP:survival): The protein is Parsylated but cannot be depicted as such in the program. Glutamic acids are parsylated. PMID:17825467 Both TNKS are required for parsylation of AXIN1/2 PMID:19759537 PMID:21799911 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tankyrase TRF1-interacting ankyrin-related ADP-ribose polymerase 2 HUGO:TNKS2 HGNC:15677 ENTREZ:80351 UNIPROT:Q9H2K2 GENECARDS:TNKS2 KEGG:80351 ATLASONC:GC_TNKS2 WIKI:TNKS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22154485 References_end</body> </html> </notes> <label text="TNKS2"/> <bbox w="80.0" h="40.0" x="17003.0" y="1303.0"/> <glyph class="state variable" id="_79f0511b-8e03-4764-99d6-05fe67141476"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="17078.0" y="1298.0"/> </glyph> <glyph class="state variable" id="_ffc8253f-14e1-457d-9d82-e4e47b44a403"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16998.0" y="1298.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s25_wca1_wca2_sa22" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re8(MAP:survival): PMID:19759537 PMID:21799911 PMID:21478859 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="17287.0" y="1207.0"/> <glyph class="state variable" id="_02fca2c4-c038-4be8-974e-747bd34da547"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="17274.992" y="1202.0"/> </glyph> <glyph class="state variable" id="_033a3bf6-f936-4b9d-b78e-398e6aabb0c6"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="17314.531" y="1202.0"/> </glyph> <glyph class="state variable" id="_1f1ca743-2efa-4b3d-8f86-1b805b1446e4"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="17352.0" y="1202.2147"/> </glyph> <glyph class="state variable" id="_a5e691ef-f08b-4bda-9a24-1ff8b0dbdad0"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="17351.38" y="1242.0"/> </glyph> <glyph class="state variable" id="_29fcfd4f-593f-42f4-8b7b-a8c10572e55a"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="17311.904" y="1242.0"/> </glyph> <glyph class="state variable" id="_652d1df9-4cc8-404d-b877-ba1d1afd5daf"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="17272.0" y="1241.7223"/> </glyph> <glyph class="state variable" id="_acb76181-336c-4fe5-850c-7cff45f15313"> <state value="Ub" variable="K48"/> <bbox w="35.0" h="10.0" x="17309.404" y="1242.0"/> </glyph> <glyph class="state variable" id="_49d6992e-0eeb-4bdf-a06e-b9c205f0d380"> <state value="Ub" variable="K11"/> <bbox w="35.0" h="10.0" x="17348.88" y="1242.0"/> </glyph> <glyph class="state variable" id="_8d073ba6-8b03-4fd2-bbd4-21b0c4681de2"> <state value="?" variable="E"/> <bbox w="20.0" h="10.0" x="17357.0" y="1202.2147"/> </glyph> <glyph class="state variable" id="_e9cd4acb-1092-4c65-be7e-18ee8bcacf3f"> <state value="Ub" variable="K63"/> <bbox w="35.0" h="10.0" x="17269.5" y="1241.7223"/> </glyph> <glyph class="state variable" id="_27c5c0f1-6edf-48a5-b937-6290e00d1117"> <state value="?" variable="E"/> <bbox w="20.0" h="10.0" x="17277.492" y="1202.0"/> </glyph> <glyph class="state variable" id="_c1e36d55-a2e3-416d-a449-40c771131276"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="17282.0" y="1202.0"/> </glyph> <glyph class="state variable" id="_20568147-5d49-4728-a58e-d13dcfd2b86a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="17362.0" y="1202.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s26_wca1_wca2_sa23" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re8(MAP:survival): PMID:19759537 PMID:21799911 PMID:21478859 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ring finger protein 146 HUGO:RNF146 HGNC:21336 ENTREZ:81847 UNIPROT:Q9NTX7 GENECARDS:RNF146 KEGG:81847 ATLASONC:GC_RNF146 WIKI:RNF146 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22274711 References_end</body> </html> </notes> <label text="RNF146"/> <bbox w="80.0" h="40.0" x="17189.5" y="1115.0"/> <glyph class="state variable" id="_b9f2ed63-fde9-4214-9a11-e9492c13a2d4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="17264.5" y="1150.0"/> </glyph> <glyph class="state variable" id="_5286d69d-e639-485d-ad93-4808c2a7f785"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="17264.5" y="1110.0"/> </glyph> <glyph class="state variable" id="_d1eb965d-a781-4a5d-96ae-a8ce56b01805"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="17184.5" y="1150.0"/> </glyph> <glyph class="state variable" id="_528369da-9b1d-4e20-9e61-5fe79cb0b136"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="17184.5" y="1110.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s28_wca1_wca2_sa25" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re14(MAP:survival): PMID:19759537 PMID:21799911 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tankyrase TRF1-interacting ankyrin-related ADP-ribose polymerase HUGO:TNKS HGNC:11941 ENTREZ:8658 UNIPROT:O95271 GENECARDS:TNKS KEGG:8658 ATLASONC:TNKSID43534ch8p23 WIKI:TNKS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22154485 References_end</body> </html> </notes> <label text="TNKS1*"/> <clone/> <bbox w="80.0" h="40.0" x="16893.5" y="1045.0"/> <glyph class="state variable" id="_d8dd8fbe-df4e-4bcf-bc60-c2744372ad54"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="16966.0" y="1040.0"/> </glyph> <glyph class="state variable" id="_820e622c-f306-458b-a92d-d4b4564bafa5"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="16886.0" y="1040.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s28_wca1_wca2_sa29" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re14(MAP:survival): PMID:19759537 PMID:21799911 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tankyrase TRF1-interacting ankyrin-related ADP-ribose polymerase HUGO:TNKS HGNC:11941 ENTREZ:8658 UNIPROT:O95271 GENECARDS:TNKS KEGG:8658 ATLASONC:TNKSID43534ch8p23 WIKI:TNKS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22154485 References_end</body> </html> </notes> <label text="TNKS1*"/> <clone/> <bbox w="80.0" h="40.0" x="17046.5" y="1045.0"/> <glyph class="state variable" id="_84faade3-d558-47a2-8336-7e420db5a219"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="17119.0" y="1040.0"/> </glyph> <glyph class="state variable" id="_aaa80d91-8b92-4b5b-a073-7d6f9dfa4d53"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="17039.0" y="1040.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s29_wca1_wca2_sa26" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re15(MAP:survival): PMID:19759537 PMID:21799911 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tankyrase TRF1-interacting ankyrin-related ADP-ribose polymerase 2 HUGO:TNKS2 HGNC:15677 ENTREZ:80351 UNIPROT:Q9H2K2 GENECARDS:TNKS2 KEGG:80351 ATLASONC:GC_TNKS2 WIKI:TNKS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22154485 References_end</body> </html> </notes> <label text="TNKS2"/> <clone/> <bbox w="80.0" h="40.0" x="16896.5" y="1378.0"/> <glyph class="state variable" id="_2ae43b9b-7649-4341-a403-e1535c8e510e"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="16969.0" y="1373.0"/> </glyph> <glyph class="state variable" id="_127fbe01-c5dd-4318-90c9-1cdcfc0dd48d"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="16889.0" y="1373.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s29_wca1_wca2_sa30" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re15(MAP:survival): PMID:19759537 PMID:21799911 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tankyrase TRF1-interacting ankyrin-related ADP-ribose polymerase 2 HUGO:TNKS2 HGNC:15677 ENTREZ:80351 UNIPROT:Q9H2K2 GENECARDS:TNKS2 KEGG:80351 ATLASONC:GC_TNKS2 WIKI:TNKS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22154485 References_end</body> </html> </notes> <label text="TNKS2"/> <clone/> <bbox w="80.0" h="40.0" x="17081.5" y="1378.0"/> <glyph class="state variable" id="_050ef307-9029-4d25-9470-1083d3d8179f"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="17154.0" y="1373.0"/> </glyph> <glyph class="state variable" id="_616854ba-c168-4fc6-bfcc-2c4af4f871dc"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="17074.0" y="1373.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s30_wca1_wca2_sa27" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re12(MAP:survival): PMID:19759537 PMID:21799911 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ring finger protein 146 HUGO:RNF146 HGNC:21336 ENTREZ:81847 UNIPROT:Q9NTX7 GENECARDS:RNF146 KEGG:81847 ATLASONC:GC_RNF146 WIKI:RNF146 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22274711 References_end</body> </html> </notes> <label text="RNF146"/> <bbox w="80.0" h="40.0" x="17189.5" y="1037.0"/> <glyph class="state variable" id="_aa6ee3f0-4c26-4116-b8a6-8cd847a6addc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="17264.5" y="1072.0"/> </glyph> <glyph class="state variable" id="_1d12e846-67c2-494f-89f5-a736e429e815"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="17262.0" y="1032.0"/> </glyph> <glyph class="state variable" id="_979df587-30f0-4eb9-9bc1-6456ab585805"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="17184.5" y="1072.0"/> </glyph> <glyph class="state variable" id="_b9f0de12-e7d2-4b2f-979a-fe9b18bf993a"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="17182.0" y="1032.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s31_wca1_wca2_sa28" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re16(MAP:survival): PMID:19759537 PMID:21799911 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ring finger protein 146 HUGO:RNF146 HGNC:21336 ENTREZ:81847 UNIPROT:Q9NTX7 GENECARDS:RNF146 KEGG:81847 ATLASONC:GC_RNF146 WIKI:RNF146 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22274711 References_end</body> </html> </notes> <label text="RNF146"/> <bbox w="80.0" h="40.0" x="17327.5" y="1037.0"/> <glyph class="state variable" id="_51a6e88b-2d57-4fa1-ad90-107dab91e32b"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="17397.5" y="1072.0"/> </glyph> <glyph class="state variable" id="_fd2c4a07-c604-4872-8bbd-e4921840749d"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="17400.0" y="1032.0"/> </glyph> <glyph class="state variable" id="_c2372482-5acb-48de-8d7c-506d84b3ec39"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="17317.5" y="1072.0"/> </glyph> <glyph class="state variable" id="_0a6d10e8-58f3-4fcc-9c8c-d7f832c615f4"> <state value="?" variable=""/> <bbox w="15.0" h="10.0" x="17320.0" y="1032.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s32_wca1_wca2_sa31" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re24:(MAP:survival) PMID:17804805 s_wca2_re25(MAP:survival): Kremen interacts w/ RSPO1 thereby releasing LRP5/6 which can is used for canonical wnt signalling PMID:12050670 s_wca2_re70:(MAP:survival) PMID:23022962 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <clone/> <bbox w="80.0" h="50.0" x="16168.0" y="745.0"/> <glyph class="state variable" id="_38cd8941-fa2e-4810-b463-6a4838c9e0c1"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="16150.5" y="764.9602"/> </glyph> <glyph class="state variable" id="_789dcac1-ab5e-4408-80ce-e7ea6c46dc48"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="16190.532" y="740.0"/> </glyph> <glyph class="state variable" id="_0d49d20c-28a5-40be-89d5-9f2de6b6905f"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="16230.5" y="740.26843"/> </glyph> <glyph class="state variable" id="_a3d3535e-ab5e-4406-a9d9-c462c9151ff7"> <state value="" variable="S1496"/> <bbox w="35.0" h="10.0" x="16229.882" y="790.0"/> </glyph> <glyph class="state variable" id="_ca52113c-6931-4ece-b103-cda5d6c587fd"> <state value="" variable="T1530"/> <bbox w="35.0" h="10.0" x="16189.6045" y="790.0"/> </glyph> <glyph class="state variable" id="_75cd9d25-60fe-4d1d-838d-b80bcaabd669"> <state value="" variable="S1533"/> <bbox w="35.0" h="10.0" x="16150.74" y="790.0"/> </glyph> <glyph class="unit of information" id="_46ab249c-4c00-46f0-9875-876166a0b767"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="16185.5" y="740.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s32_wca1_wca2_sa58" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re24:(MAP:survival) PMID:17804805 s_wca2_re25(MAP:survival): Kremen interacts w/ RSPO1 thereby releasing LRP5/6 which can is used for canonical wnt signalling PMID:12050670 s_wca2_re70:(MAP:survival) PMID:23022962 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <clone/> <bbox w="80.0" h="50.0" x="17158.0" y="745.0"/> <glyph class="state variable" id="_e4a1cb1b-cad0-4669-94d3-47e98cf62545"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="17140.5" y="764.9602"/> </glyph> <glyph class="state variable" id="_eb0f4c2b-4795-46d1-bc62-d5a841249a2c"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="17180.531" y="740.0"/> </glyph> <glyph class="state variable" id="_765826ef-0be2-410a-a622-6ee075ab74ec"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="17220.5" y="740.26843"/> </glyph> <glyph class="state variable" id="_7c4e590c-bb62-4ae1-ab13-017a64669c30"> <state value="" variable="S1496"/> <bbox w="35.0" h="10.0" x="17219.88" y="790.0"/> </glyph> <glyph class="state variable" id="_83735a83-a6d8-419c-9ca4-c94bffc1d282"> <state value="" variable="T1530"/> <bbox w="35.0" h="10.0" x="17179.604" y="790.0"/> </glyph> <glyph class="state variable" id="_2060a05a-7106-4a09-a929-fac4314fc8fd"> <state value="" variable="S1533"/> <bbox w="35.0" h="10.0" x="17140.74" y="790.0"/> </glyph> <glyph class="unit of information" id="_948d7c60-cfa2-4d0f-a0a6-d964df602e95"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="17175.5" y="740.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s33_wca1_wca2_sa32"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re24:(MAP:survival) PMID:17804805 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dickkopf 1 homolog (Xenopus laevis) "dickkopf (Xenopus laevis) homolog 1" HUGO:DKK1 HGNC:2891 ENTREZ:22943 UNIPROT:O94907 GENECARDS:DKK1 KEGG:22943 ATLASONC:DKK1ID44007ch10q11 WIKI:DKK1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22807036 References_end</body> </html> </notes> <label text="DKK1"/> <clone/> <bbox w="40.0" h="20.0" x="16090.0" y="680.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s33_wca1_wca2_sa61"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re24:(MAP:survival) PMID:17804805 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dickkopf 1 homolog (Xenopus laevis) "dickkopf (Xenopus laevis) homolog 1" HUGO:DKK1 HGNC:2891 ENTREZ:22943 UNIPROT:O94907 GENECARDS:DKK1 KEGG:22943 ATLASONC:DKK1ID44007ch10q11 WIKI:DKK1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22807036 References_end</body> </html> </notes> <label text="DKK1"/> <clone/> <bbox w="40.0" h="20.0" x="17060.0" y="660.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s66_wca1_wca2_sa52" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re20(MAP:survival): PMID:11433302 PMID:11448771 PMID:12050670 s_wca2_re26:(MAP:survival) PMID:20370576 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: kringle containing transmembrane protein 1 HUGO:KREMEN1 HGNC:17550 ENTREZ:83999 UNIPROT:Q96MU8 GENECARDS:KREMEN1 KEGG:83999 WIKI:KREMEN1 kringle containing transmembrane protein 2 HUGO:KREMEN2 HGNC:18797 ENTREZ:79412 UNIPROT:Q8NCW0 GENECARDS:KREMEN2 KEGG:79412 WIKI:KREMEN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="KRM*"/> <bbox w="35.0" h="60.0" x="16100.5" y="740.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s67_wca1_wca2_sa53"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re24:(MAP:survival) PMID:17804805 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: R-spondin 1 "R-spondin homolog (Xenopus laevis)" HUGO:RSPO1 HGNC:21679 ENTREZ:284654 UNIPROT:Q2MKA7 GENECARDS:RSPO1 KEGG:284654 ATLASONC:RSPO1ID44137ch1p34 WIKI:RSPO1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RSPO1"/> <bbox w="80.0" h="40.0" x="16646.0" y="598.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s82_wca1_wca2_sa64"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re26:(MAP:survival) PMID:20370576 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dickkopf 3 homolog (Xenopus laevis) HUGO:DKK3 HGNC:2893 ENTREZ:27122 UNIPROT:Q9UBP4 GENECARDS:DKK3 KEGG:27122 ATLASONC:GC_DKK3 WIKI:DKK3 "dickkopf (Xenopus laevis) homolog 3" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="DKK3"/> <bbox w="40.0" h="20.0" x="16019.0" y="661.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s95_wca1_wca2_sa69" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re30(MAP:survival): Shown in Xenopus embryos that dimerisation of XFZ3 correlates with activation. This phenomenon is described once in: PMID:12734397 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Xenopus homologue References_end</body> </html> </notes> <label text="XFZ3"/> <bbox w="80.0" h="50.0" x="17298.0" y="763.0"/> <glyph class="unit of information" id="_286f3b5a-42d8-4440-a6d2-b7214974c7fd"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="17315.5" y="758.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s96_wca1_wca2_sa72"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="17220.0" y="680.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s98_wca1_wca2_sa74" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re31(MAP:survival): XFZ7 is normally a monomer howerver upon forced dimerisation the receptor gets activated. This phenomenom is described once in: PMID:12734397 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Xenopus homologue References_end</body> </html> </notes> <label text="XFZ7"/> <clone/> <bbox w="80.0" h="50.0" x="17558.0" y="755.0"/> <glyph class="unit of information" id="_4ed30ad5-57cc-49be-8c49-3bacf21d7b30"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="17575.5" y="750.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s98_wca1_wca2_sa77" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re31(MAP:survival): XFZ7 is normally a monomer howerver upon forced dimerisation the receptor gets activated. This phenomenom is described once in: PMID:12734397 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Xenopus homologue References_end</body> </html> </notes> <label text="XFZ7"/> <clone/> <bbox w="80.0" h="50.0" x="17648.0" y="755.0"/> <glyph class="unit of information" id="_17861055-b1c3-4a4e-96b3-19aeea026232"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="17665.5" y="750.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s102_wca1_wca2_sa78" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re33:(MAP:survival) PMID:14747478 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 6 "frizzled (Drosophila) homolog 6" "frizzled 6 seven transmembrane spanning receptor" "frizzled homolog 6 (Drosophila)" HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="FZD6"/> <bbox w="80.0" h="50.0" x="17658.0" y="965.0"/> <glyph class="unit of information" id="_6a25c1c9-34f2-41d6-accc-b5c2377932e4"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="17675.5" y="960.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s133_wca1_wca2_sa102" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re39(MAP:survival): Integrin alphaIII beta1 can activate Src PMID:22203675 Other integrin family member activates as well Src PMID:19734908 s_wca2_re45(MAP:survival): Src phosphorylates Y654 residue on b-catenin PMID:16099633 s_wca2_re68:(MAP:survival) PMID:22370635 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) SRC1 "v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog" HUGO:SRC HGNC:11283 ENTREZ:6714 UNIPROT:P12931 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Many activated RTKs induce the Src-dependent activation of PLCG PMID:17496910 References_end Identifiers_begin: v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) SRC1 "v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog" HUGO:SRC HGNC:11283 ENTREZ:6714 UNIPROT:P12931 GENECARDS:SRC REACTOME:402877 KEGG:6714 ATLASONC:SRCID448ch20q11 WIKI:SRC Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Many activated RTKs induce the Src-dependent activation of PLCG PMID:17496910 References_end</body> </html> </notes> <label text="SRC"/> <clone/> <bbox w="80.0" h="40.0" x="15955.0" y="1718.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s133_wca1_wca2_sa103" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re39(MAP:survival): Integrin alphaIII beta1 can activate Src PMID:22203675 Other integrin family member activates as well Src PMID:19734908 s_wca2_re45(MAP:survival): Src phosphorylates Y654 residue on b-catenin PMID:16099633 s_wca2_re68:(MAP:survival) PMID:22370635 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) SRC1 "v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog" HUGO:SRC HGNC:11283 ENTREZ:6714 UNIPROT:P12931 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Many activated RTKs induce the Src-dependent activation of PLCG PMID:17496910 References_end Identifiers_begin: v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) SRC1 "v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog" HUGO:SRC HGNC:11283 ENTREZ:6714 UNIPROT:P12931 GENECARDS:SRC REACTOME:402877 KEGG:6714 ATLASONC:SRCID448ch20q11 WIKI:SRC Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Many activated RTKs induce the Src-dependent activation of PLCG PMID:17496910 References_end</body> </html> </notes> <label text="SRC"/> <clone/> <bbox w="80.0" h="40.0" x="16133.0" y="1718.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s135_wca1_wca2_sa104" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re40:(MAP:survival) PMID:22203675 s_wca2_re69:(MAP:survival) PMID:22370635 s_wca2_re42(MAP:survival): Degradation by GSK3/AXIN (destruction complex) is the same as for the canonical-isoform of beta-catenin (no PTM) PMID:22203675 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="15734.0" y="1744.0"/> <glyph class="state variable" id="_6e175df7-a201-413b-98e2-fa706b4c9ecb"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="15761.404" y="1779.0"/> </glyph> <glyph class="state variable" id="_b9cdb529-b9b9-4209-8c94-ce20123e9cf0"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="15800.882" y="1779.0"/> </glyph> <glyph class="state variable" id="_22530f97-4a4a-430d-807a-4cacf1d6d955"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="15801.5" y="1739.2147"/> </glyph> <glyph class="state variable" id="_7656cf7e-f622-4346-bcc7-c4786e56d79a"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="15761.532" y="1739.0"/> </glyph> <glyph class="state variable" id="_e8cdde68-74f3-427b-bb17-2e8788124e02"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="15721.992" y="1739.0"/> </glyph> <glyph class="state variable" id="_aa54b5a8-90ce-4f3f-89b7-3637772dc45e"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="15721.5" y="1778.7223"/> </glyph> <glyph class="state variable" id="_0fc6315c-493c-435a-acc1-f782ef54d80c"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="15799.0" y="1739.2147"/> </glyph> <glyph class="state variable" id="_907674d2-659e-4441-870f-e5e8258f7672"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="15799.0" y="1739.2147"/> </glyph> <glyph class="state variable" id="_8a7b6fc3-e129-4382-9d68-1df679937be8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15729.0" y="1759.0"/> </glyph> <glyph class="state variable" id="_0d4d9cc3-b10f-4062-b65e-0981c0bb222e"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="15719.492" y="1739.0"/> </glyph> <glyph class="state variable" id="_9e670a98-6934-4ec6-9720-89a8e5dd11b4"> <state value="P" variable="Y654"/> <bbox w="35.0" h="10.0" x="15796.5" y="1739.2147"/> </glyph> <glyph class="state variable" id="_51acfec9-f2a1-42ba-80b3-caf96ae91550"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15729.0" y="1750.7157"/> </glyph> <glyph class="state variable" id="_dca7101e-07f2-4dce-b949-4a2977a42eef"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="15799.0" y="1739.2147"/> </glyph> <glyph class="state variable" id="_c7ecd272-4c96-4903-8971-3de041c54137"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15729.0" y="1759.0"/> </glyph> <glyph class="state variable" id="_f3c2c5b5-9d66-4f8a-9698-910daaa6e10a"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="15798.382" y="1779.0"/> </glyph> <glyph class="state variable" id="_26378bff-df5c-4298-bd1a-b2c73bb05a1c"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="15799.0" y="1739.2147"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s137_wca1_wca2_sa106" compartmentRef="wca1_wca2_c3_wca1_wca2_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re42(MAP:survival): Degradation by GSK3/AXIN (destruction complex) is the same as for the canonical-isoform of beta-catenin (no PTM) PMID:22203675 s_wca2_re47:(MAP:survival) PMID:19104148 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="15997.0" y="1839.5"/> <glyph class="state variable" id="_943015f2-c3ce-40dd-9101-afd2c2486360"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="16024.404" y="1874.5"/> </glyph> <glyph class="state variable" id="_b8ab7c08-939b-4eff-9cb6-67d174867f1c"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="16063.882" y="1874.5"/> </glyph> <glyph class="state variable" id="_13ffee84-f1a5-42b6-a6c0-6dff01498dea"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="16064.5" y="1834.7147"/> </glyph> <glyph class="state variable" id="_3e62e9e0-d207-4c10-bacd-98b6fa7bd3b3"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="16024.532" y="1834.5"/> </glyph> <glyph class="state variable" id="_72fc3b97-7922-489e-a893-6a8745fc4abd"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="15984.992" y="1834.5"/> </glyph> <glyph class="state variable" id="_e1306812-c782-4d52-bee4-a8ee17abbe7c"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="15984.5" y="1874.2223"/> </glyph> <glyph class="state variable" id="_b83de4e5-7bdd-4cb8-b349-c5218cbf3eb5"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="16062.0" y="1834.7147"/> </glyph> <glyph class="state variable" id="_97329aa2-545c-409f-bfbe-8c6003f53ecc"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="16062.0" y="1834.7147"/> </glyph> <glyph class="state variable" id="_bdacabeb-f377-4f1e-a36b-b389dea7260d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15992.0" y="1854.5"/> </glyph> <glyph class="state variable" id="_ad8cff22-09a5-4755-b2dc-972febeca508"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="15982.492" y="1834.5"/> </glyph> <glyph class="state variable" id="_18262846-fd10-47e7-a9c7-5906ea67d386"> <state value="P" variable="Y654"/> <bbox w="35.0" h="10.0" x="16059.5" y="1834.7147"/> </glyph> <glyph class="state variable" id="_2dafb336-691d-4bb5-bc68-90c273e2d47c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15992.0" y="1846.2157"/> </glyph> <glyph class="state variable" id="_77794a0f-92da-49d4-8ed1-762f67d79340"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="16062.0" y="1834.7147"/> </glyph> <glyph class="state variable" id="_9251d593-477d-40b4-baae-66c87308e427"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15992.0" y="1854.5"/> </glyph> <glyph class="state variable" id="_557a0014-5d69-40ea-b112-a21ed594c427"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="16061.382" y="1874.5"/> </glyph> <glyph class="state variable" id="_157d1855-7a1f-48f1-b68a-61d83f0af9e5"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="16062.0" y="1834.7147"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s167_wca1_wca2_sa121" compartmentRef="wca1_wca2_c3_wca1_wca2_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re48:(MAP:survival) part of canonical TGF pathway s_wca2_re47:(MAP:survival) PMID:19104148 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: SMAD family member 2 "MAD mothers against decapentaplegic homolog 2 (Drosophila)" MADH2 "SMAD mothers against DPP homolog 2 (Drosophila)" HUGO:SMAD2 HGNC:6768 ENTREZ:4087 UNIPROT:Q15796 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TGF-?? exerts its biological effects by binding to a cell surface receptor complex composed of type I (TbRI) and type II (TbRII) receptor serine/threonine kinases. Upon ligand binding TbRII phosphorylates and activates TbRI which subsequently phosphorylates the cytoplasmic Smad2 and Smad3 proteins. Phosphorylated Smad proteins form stable complexes with a common partner Smad4. The activated Smad2/4 and Smad3/4 complexes translocate into the nucleus where the Smad oligomers induce transcriptional activation (or inhibition) of specific target genes. PMID:21614932 References_end Identifiers_begin: SMAD family member 2 "MAD mothers against decapentaplegic homolog 2 (Drosophila)" MADH2 "SMAD mothers against DPP homolog 2 (Drosophila)" HUGO:SMAD2 HGNC:6768 ENTREZ:4087 UNIPROT:Q15796 GENECARDS:SMAD2 REACTOME:405890 KEGG:4087 ATLASONC:SMAD2ID370 WIKI:SMAD2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: TGF-?? exerts its biological effects by binding to a cell surface receptor complex composed of type I (TbRI) and type II (TbRII) receptor serine/threonine kinases. Upon ligand binding TbRII phosphorylates and activates TbRI which subsequently phosphorylates the cytoplasmic Smad2 and Smad3 proteins. Phosphorylated Smad proteins form stable complexes with a common partner Smad4. The activated Smad2/4 and Smad3/4 complexes translocate into the nucleus where the Smad oligomers induce transcriptional activation (or inhibition) of specific target genes. PMID:21614932 References_end</body> </html> </notes> <label text="SMAD2"/> <bbox w="80.0" h="40.0" x="15999.0" y="1910.0"/> <glyph class="state variable" id="_e175a58c-b4a4-4534-9bc0-e3a154f2cb0d"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="16071.5" y="1905.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s174_wca1_wca2_sa126" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wnc4_re31(MAP:survival): binding of G-alpha12 toE-cadherin results of loss of binding of b-catenin from the adherence junction PMID:11136230 s_wca2_re50:(MAP:survival) PMID:22659456 PMID:22007144 PMID:19171760 PMID:10931041 s_wnc4_re24(MAP:survival): Complex of G-alpha12 and p120 stabilises binding of E-cadherin in Adhesion-complex. G-alpha12 is found back in complex with p120 and E-cadherin PMID:15240885 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: catenin (cadherin-associated protein) alpha 1 102kDa HUGO:CTNNA1 HGNC:2509 ENTREZ:1495 UNIPROT:P35221 GENECARDS:CTNNA1 REACTOME:53044 KEGG:1495 ATLASONC:GC_CTNNA1 WIKI:CTNNA1 catenin (cadherin-associated protein) alpha 2 HUGO:CTNNA2 HGNC:2510 ENTREZ:1496 UNIPROT:P26232 GENECARDS:CTNNA2 REACTOME:53046 KEGG:1496 WIKI:CTNNA2 catenin (cadherin-associated protein) alpha 3 HUGO:CTNNA3 HGNC:2511 ENTREZ:29119 UNIPROT:Q9UI47 GENECARDS:CTNNA3 KEGG:29119 ATLASONC:GC_CTNNA3 WIKI:CTNNA3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: catenin (cadherin-associated protein) alpha 1 102kDa HUGO:CTNNA1 HGNC:2509 ENTREZ:1495 UNIPROT:P35221 GENECARDS:CTNNA1 REACTOME:53044 KEGG:1495 ATLASONC:GC_CTNNA1 WIKI:CTNNA1 catenin (cadherin-associated protein) alpha 2 HUGO:CTNNA2 HGNC:2510 ENTREZ:1496 UNIPROT:P26232 GENECARDS:CTNNA2 REACTOME:53046 KEGG:1496 WIKI:CTNNA2 catenin (cadherin-associated protein) alpha 3 HUGO:CTNNA3 HGNC:2511 ENTREZ:29119 UNIPROT:Q9UI47 GENECARDS:CTNNA3 KEGG:29119 ATLASONC:GC_CTNNA3 WIKI:CTNNA3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="α-Catenin*"/> <bbox w="80.0" h="40.0" x="15701.0" y="1118.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s176_wca1_wca2_sa128" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re50:(MAP:survival) PMID:22659456 PMID:22007144 PMID:19171760 PMID:10931041 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: integrin alpha 3 (antigen CD49C alpha 3 subunit of VLA-3 receptor) "antigen identified by monoclonal antibody J143" MSK18 HUGO:ITGA3 HGNC:6139 ENTREZ:3675 UNIPROT:P26006 GENECARDS:ITGA3 REACTOME:57565 KEGG:3675 ATLASONC:GC_ITGA3 WIKI:ITGA3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_MATRIX_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ITGA3"/> <bbox w="80.0" h="40.0" x="15500.0" y="924.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s177_wca1_wca2_sa136" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wnc4_re31(MAP:survival): binding of G-alpha12 toE-cadherin results of loss of binding of b-catenin from the adherence junction PMID:11136230 s_wca2_re53:(MAP:survival) PMID:10671551 PMID:10837139 s_wnc4_re24(MAP:survival): Complex of G-alpha12 and p120 stabilises binding of E-cadherin in Adhesion-complex. G-alpha12 is found back in complex with p120 and E-cadherin PMID:15240885 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="123.0" h="41.0" x="15685.0" y="1356.0"/> <glyph class="state variable" id="_4096070f-e3e1-45d5-86af-9f6d3bc8ed61"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15803.0" y="1351.0"/> </glyph> <glyph class="state variable" id="_1469cef8-372d-407c-ac1d-8e7f253c7fdd"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="15671.96" y="1351.0"/> </glyph> <glyph class="state variable" id="_ee7942e3-34bc-4d26-8c87-a562ee648626"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="15793.0" y="1351.2201"/> </glyph> <glyph class="state variable" id="_1af635e6-0532-48db-a105-a61d996a1979"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="15788.52" y="1392.0"/> </glyph> <glyph class="state variable" id="_e82c0236-d944-4e76-bdf2-f5ed7e81d745"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="15670.369" y="1392.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s178_wca1_wca2_sa130" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wnc4_re31(MAP:survival): binding of G-alpha12 toE-cadherin results of loss of binding of b-catenin from the adherence junction PMID:11136230 s_wca2_re50:(MAP:survival) PMID:22659456 PMID:22007144 PMID:19171760 PMID:10931041 s_wnc4_re24(MAP:survival): Complex of G-alpha12 and p120 stabilises binding of E-cadherin in Adhesion-complex. G-alpha12 is found back in complex with p120 and E-cadherin PMID:15240885 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="15703.0" y="1002.0"/> <glyph class="state variable" id="_6c3fc13f-bec5-418d-96df-04d10c4d1ec8"> <state value="" variable="S268"/> <bbox w="30.0" h="10.0" x="15688.492" y="997.0"/> </glyph> <glyph class="state variable" id="_c6558794-8f7e-420b-9a03-fe5bbbc7eafc"> <state value="" variable="S269"/> <bbox w="30.0" h="10.0" x="15728.032" y="997.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s183_wca1_wca2_sa133" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re52:(MAP:survival) PMID:19244247 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <clone/> <bbox w="80.0" h="40.0" x="15821.0" y="1004.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s183_wca1_wca2_sa134" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re52:(MAP:survival) PMID:19244247 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <clone/> <bbox w="80.0" h="40.0" x="15821.0" y="1116.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s192_wca1_wca2_sa137" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re53:(MAP:survival) PMID:10671551 PMID:10837139 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="123.0" h="41.0" x="15686.0" y="1273.0"/> <glyph class="state variable" id="_29ad50be-4312-4fa9-9af2-d0457830ef1d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15804.0" y="1268.0"/> </glyph> <glyph class="state variable" id="_4917ff82-2110-45bf-b139-03b2bca6f92e"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="15672.96" y="1268.0"/> </glyph> <glyph class="state variable" id="_59818fd8-6fed-4c74-9b6c-33c755815bc4"> <state value="P" variable="S853"/> <bbox w="35.0" h="10.0" x="15791.5" y="1268.2201"/> </glyph> <glyph class="state variable" id="_d4668de9-7d27-420f-bd63-0abeba792ccf"> <state value="P" variable="S855"/> <bbox w="35.0" h="10.0" x="15787.02" y="1309.0"/> </glyph> <glyph class="state variable" id="_3510508b-739b-40b0-8cab-5bb5123e6049"> <state value="P" variable="S840"/> <bbox w="35.0" h="10.0" x="15668.869" y="1309.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s202_wca1_wca2_sa129" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re54:(MAP:survival) PMID:10671551 s_wca2_re50:(MAP:survival) PMID:22659456 PMID:22007144 PMID:19171760 PMID:10931041 s_wca2_re67:(MAP:survival) PMID:22370635 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="123.0" h="41.0" x="15685.0" y="1184.0"/> <glyph class="state variable" id="_7fade615-3d7f-4dae-ba13-5f990acde966"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15803.0" y="1179.0"/> </glyph> <glyph class="state variable" id="_cad90885-88cd-40db-8aab-cf78c959fc13"> <state value="P" variable="S849"/> <bbox w="35.0" h="10.0" x="15669.46" y="1179.0"/> </glyph> <glyph class="state variable" id="_4d73b3ea-e520-4d91-8dd1-394071a69e01"> <state value="P" variable="S853"/> <bbox w="35.0" h="10.0" x="15790.5" y="1179.2201"/> </glyph> <glyph class="state variable" id="_219d78a9-68ae-4e9a-97f2-2eddba53cff5"> <state value="P" variable="S855"/> <bbox w="35.0" h="10.0" x="15786.02" y="1220.0"/> </glyph> <glyph class="state variable" id="_dd02ed54-08fc-4985-9227-2b33ff6be819"> <state value="P" variable="S840"/> <bbox w="35.0" h="10.0" x="15667.869" y="1220.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s211_wca1_wca2_sa142" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end</body> </html> </notes> <label text="GSK3β*"/> <bbox w="80.0" h="40.0" x="15838.0" y="1229.0"/> <glyph class="state variable" id="_ae0bc2d6-3cb5-49a4-8be3-4373ffa149d3"> <state value="" variable="S9"/> <bbox w="20.0" h="10.0" x="15828.492" y="1224.0"/> </glyph> <glyph class="state variable" id="_f10d0f2c-f09f-4e15-93c8-f5529efbc820"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15833.0" y="1244.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s212_wca1_wca2_sa143" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re55:(MAP:survival) PMID:21536646 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: transmembrane protein 198 HUGO:TMEM198 HGNC:33704 ENTREZ:130612 UNIPROT:Q66K66 GENECARDS:TMEM198 KEGG:130612 WIKI:TMEM198 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TMEM198"/> <bbox w="80.0" h="40.0" x="15492.0" y="1869.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s213_wca1_wca2_sa144" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re60(MAP:survival): Without RIPK4 upon wnt3 stimulation 25% of HeLa cells show DVL2 in puncta. Co-transfection of RIPK4 increases this number to more than 75% PMID:23371553 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LRP6"/> <clone/> <bbox w="80.0" h="50.0" x="15493.0" y="1935.0"/> <glyph class="state variable" id="_d22ac22e-0370-4722-891e-16300b39eba5"> <state value="" variable="T1572"/> <bbox w="35.0" h="10.0" x="15475.5" y="1954.9602"/> </glyph> <glyph class="state variable" id="_506a7940-fbe1-4b92-b601-f934471de258"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="15515.532" y="1930.0"/> </glyph> <glyph class="state variable" id="_d4870be1-8edd-469f-b643-8accfd4d783e"> <state value="" variable="S1544"/> <bbox w="35.0" h="10.0" x="15555.5" y="1930.2684"/> </glyph> <glyph class="state variable" id="_9622c471-8576-41e8-9c57-64062cdcb132"> <state value="" variable="T1548"/> <bbox w="35.0" h="10.0" x="15555.5" y="1968.4371"/> </glyph> <glyph class="state variable" id="_4051c8ed-dfff-4493-955c-0fef32953bc6"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="15555.5" y="1930.2684"/> </glyph> <glyph class="state variable" id="_30b722a5-3866-440b-b52d-409625d4defb"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="15475.992" y="1930.0"/> </glyph> <glyph class="unit of information" id="_7c1c5c6e-d65a-4835-8c5f-62bd28ecd252"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="15510.5" y="1930.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s213_wca1_wca2_sa162" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re60(MAP:survival): Without RIPK4 upon wnt3 stimulation 25% of HeLa cells show DVL2 in puncta. Co-transfection of RIPK4 increases this number to more than 75% PMID:23371553 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LRP6"/> <clone/> <bbox w="80.0" h="50.0" x="17647.0" y="1486.0"/> <glyph class="state variable" id="_8f7057d7-f8fd-4bfe-bc34-bf540e4c1697"> <state value="" variable="T1572"/> <bbox w="35.0" h="10.0" x="17629.5" y="1505.9602"/> </glyph> <glyph class="state variable" id="_bd230b60-7117-440c-86f6-dd5ab612ec07"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="17669.531" y="1481.0"/> </glyph> <glyph class="state variable" id="_76e3f274-4e8c-422c-9029-3ca695f99954"> <state value="" variable="S1544"/> <bbox w="35.0" h="10.0" x="17709.5" y="1481.2684"/> </glyph> <glyph class="state variable" id="_3619ff54-e91f-47c5-9c54-edd3f866870d"> <state value="" variable="T1548"/> <bbox w="35.0" h="10.0" x="17709.5" y="1519.4371"/> </glyph> <glyph class="state variable" id="_8013e9a5-1790-4256-88fb-3d6ef45e2662"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="17709.5" y="1481.2684"/> </glyph> <glyph class="state variable" id="_ed445075-3d4d-444e-82a2-4ea23146a3a8"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="17629.992" y="1481.0"/> </glyph> <glyph class="unit of information" id="_829e1136-4176-413a-be20-715cb4f6e3f1"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="17664.5" y="1481.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s221_wca1_wca2_sa149" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end</body> </html> </notes> <label text="CK1*"/> <bbox w="80.0" h="40.0" x="15601.0" y="1973.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s234_wca1_wca2_sa159" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re58(MAP:survival): DVL and RIPK4 form constitutively a complex PMID:23371553 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: receptor-interacting serine-threonine kinase 4 ANKRD3 "ankyrin repeat domain 3" HUGO:RIPK4 HGNC:496 ENTREZ:54101 UNIPROT:P57078 GENECARDS:RIPK4 KEGG:54101 ATLASONC:GC_RIPK4 WIKI:RIPK4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RIPK4"/> <bbox w="80.0" h="40.0" x="17230.0" y="1390.5"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s247_wca1_wca2_sa168" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re62:(MAP:survival) PMID:22705350 s_wca2_re63(MAP:survival): Ubiquination at this residue increases b-catenin protein stability and increased top-flash activity PMID:22705350 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="16065.0" y="1138.0"/> <glyph class="state variable" id="_456f98a4-245e-4545-84d6-c9e49f02bc75"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="16092.404" y="1173.0"/> </glyph> <glyph class="state variable" id="_6e59f7ca-1cae-40b7-a1d5-22cc59cf1547"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="16131.882" y="1173.0"/> </glyph> <glyph class="state variable" id="_10cdee45-0bb1-4048-9e58-e4f1e42ecf1e"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="16132.5" y="1133.2147"/> </glyph> <glyph class="state variable" id="_dd36d675-8bba-45c3-a62f-0ea7ec8f04f9"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="16092.532" y="1133.0"/> </glyph> <glyph class="state variable" id="_f17de3e2-ae16-4beb-bad1-fac22aa6d4c6"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="16052.992" y="1133.0"/> </glyph> <glyph class="state variable" id="_92eb5e93-bbce-4a68-acf0-4b323758ed3d"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="16052.5" y="1172.7223"/> </glyph> <glyph class="state variable" id="_1c07a729-cc60-49aa-9f52-8ec7a7ace32b"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="16130.0" y="1133.2147"/> </glyph> <glyph class="state variable" id="_e06addd7-6112-4f81-b2dd-1cf631ade0e9"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="16130.0" y="1133.2147"/> </glyph> <glyph class="state variable" id="_527c2ed0-6bbb-46dc-964b-51ee8ad456bb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16060.0" y="1153.0"/> </glyph> <glyph class="state variable" id="_4c82c2b9-8acf-4467-ad45-d75a3e17e05f"> <state value="Ub" variable="K394"/> <bbox w="40.0" h="10.0" x="16045.492" y="1133.0"/> </glyph> <glyph class="state variable" id="_ef38af95-ea0a-48bc-9573-d0eb4a2b4341"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="16130.0" y="1133.2147"/> </glyph> <glyph class="state variable" id="_bb2b4b6f-8a62-4502-84da-77b781581376"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16060.0" y="1144.7157"/> </glyph> <glyph class="state variable" id="_765acb5b-7a24-45bf-8213-4c4dba1ce235"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="16130.0" y="1133.2147"/> </glyph> <glyph class="state variable" id="_8a89d567-659d-4e67-9a85-67ae0a7b8150"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16060.0" y="1153.0"/> </glyph> <glyph class="state variable" id="_34390a7c-1216-4b02-809d-db11ae630fdf"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="16129.382" y="1173.0"/> </glyph> <glyph class="state variable" id="_60038415-e74e-416f-9725-5e40f3c31ced"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="16130.0" y="1133.2147"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s248_wca1_wca2_sa169" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re62:(MAP:survival) PMID:22705350 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquitin-conjugating enzyme E2B "ubiquitin-conjugating enzyme E2B (RAD6 homolog)" HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="UBE2B"/> <bbox w="80.0" h="40.0" x="15913.0" y="1170.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s249_wca1_wca2_sa170" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="16104.0" y="1255.0"/> <glyph class="state variable" id="_ec3010c7-8ea8-4dbc-9e09-238dd9d1ab23"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="16165.882" y="1290.0"/> </glyph> <glyph class="state variable" id="_4dbed13a-be46-4880-b16f-22be6f7156a7"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="16086.992" y="1250.0"/> </glyph> <glyph class="state variable" id="_8976033f-cee7-4d42-95a3-284e2c6918a2"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="16166.5" y="1250.2147"/> </glyph> <glyph class="state variable" id="_256230d1-1680-4b7e-b4a9-1f2c2cb7314c"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="16126.404" y="1290.0"/> </glyph> <glyph class="state variable" id="_6e7adb21-9e3c-446b-b34f-c44ea7a70742"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="16126.532" y="1250.0"/> </glyph> <glyph class="state variable" id="_9f85ac94-2bda-417a-88cf-c8574130d185"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="16086.5" y="1289.7223"/> </glyph> <glyph class="state variable" id="_74bd33ad-4e8c-4119-bd7d-5ebbd7d6f5ad"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16179.0" y="1250.0"/> </glyph> <glyph class="state variable" id="_8ba4d6ac-29ff-4270-9e59-6ce6bad6ec4e"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="16166.5" y="1289.1306"/> </glyph> <glyph class="state variable" id="_b281a2c0-8512-4cba-9e1d-36d38141fecd"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="16086.5" y="1289.7223"/> </glyph> <glyph class="state variable" id="_d82f825d-1e9b-41d4-8b97-0ea7bc20c78d"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="16091.992" y="1250.0"/> </glyph> <glyph class="state variable" id="_1029d715-31e1-4cba-969a-470b1348dd5c"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="16086.992" y="1250.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s250_wca1_wca2_sa171" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re64(MAP:survival): HECTD1 KO disrupts APC-AXIN interaction and augments WNT3a-induced signaling PMID:23277359 PMID:22761442 s_wca2_re65(MAP:survival): Ubiquitination increases binding of APC with AXIN. PMID:23277359 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="16285.0" y="1256.0"/> <glyph class="state variable" id="_3c948cfa-ffd3-4e8f-b8a3-9567a54aef3f"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="16346.882" y="1291.0"/> </glyph> <glyph class="state variable" id="_187d6e01-d7e9-4b1a-825c-dac7c7cb759c"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="16267.992" y="1251.0"/> </glyph> <glyph class="state variable" id="_141579ee-9d82-4a41-91ba-1318e75ea3cd"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="16347.5" y="1251.2147"/> </glyph> <glyph class="state variable" id="_336b82a7-4efe-44d7-9d79-2162064102f0"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="16307.404" y="1291.0"/> </glyph> <glyph class="state variable" id="_e06f2eaa-db8c-4e14-8040-b88cfc33d68f"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="16307.532" y="1251.0"/> </glyph> <glyph class="state variable" id="_d963b9c9-34f7-479d-89dc-fcd3f3767827"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="16267.5" y="1290.7223"/> </glyph> <glyph class="state variable" id="_ba691edf-286b-44de-9bf1-6cd92f0edb98"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16360.0" y="1251.0"/> </glyph> <glyph class="state variable" id="_e372d0d7-b8ed-47cd-bc6d-ffb3682dedc4"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="16347.5" y="1290.1306"/> </glyph> <glyph class="state variable" id="_e4333e11-3d17-4ea6-aa9b-b472d3d586b4"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="16267.5" y="1290.7223"/> </glyph> <glyph class="state variable" id="_64059f8d-fb6e-4491-b358-e20b6f01f629"> <state value="Ub" variable="K63"/> <bbox w="35.0" h="10.0" x="16267.992" y="1251.0"/> </glyph> <glyph class="state variable" id="_97482d5c-a843-40f4-88fa-9f779beb891e"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="16267.992" y="1251.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s251_wca1_wca2_sa172" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re64(MAP:survival): HECTD1 KO disrupts APC-AXIN interaction and augments WNT3a-induced signaling PMID:23277359 PMID:22761442 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: HECT domain containing E3 ubiquitin protein ligase 1 "HECT domain containing 1" HUGO:HECTD1 HGNC:20157 ENTREZ:25831 UNIPROT:Q9ULT8 GENECARDS:HECTD1 WIKI:HECTD1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HECTD1"/> <bbox w="80.0" h="40.0" x="16195.0" y="1176.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s262_wca1_wca2_sa180" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re67:(MAP:survival) PMID:22370635 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: integrin alpha 9 HUGO:ITGA9 HGNC:6145 ENTREZ:3680 UNIPROT:Q13797 GENECARDS:ITGA9 REACTOME:57577 KEGG:3680 ATLASONC:GC_ITGA9 WIKI:ITGA9 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_MATRIX_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ITGA9"/> <bbox w="80.0" h="40.0" x="15491.0" y="2680.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s182_wca1_wca2_sa132" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re67:(MAP:survival) PMID:22370635 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <clone/> <bbox w="80.0" h="40.0" x="15604.0" y="919.86597"/> <glyph class="state variable" id="_32d3a24d-10ee-4e3a-9fe3-2b70e344e092"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="15631.404" y="954.86597"/> </glyph> <glyph class="state variable" id="_f0ece618-09f5-4982-8c33-87dc6f78e1b2"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="15670.882" y="954.86597"/> </glyph> <glyph class="state variable" id="_7d158f1c-ee5e-4f0b-a6a9-83660a968370"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="15671.5" y="915.08075"/> </glyph> <glyph class="state variable" id="_3cbde01d-b36e-4bf5-bd76-ee7d41873f86"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="15631.532" y="914.86597"/> </glyph> <glyph class="state variable" id="_1dd5fbaa-5fcf-44c6-9732-0ad543ef094e"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="15591.992" y="914.86597"/> </glyph> <glyph class="state variable" id="_5655ad4b-e8f1-4cef-830a-a07fca09d7e7"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="15591.5" y="954.58826"/> </glyph> <glyph class="state variable" id="_0ba011d5-f9b6-4a98-8d19-ad0b8d95e88c"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="15669.0" y="915.08075"/> </glyph> <glyph class="state variable" id="_3dd9421c-2b74-46cf-8bd2-c9071ab70210"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="15669.0" y="915.08075"/> </glyph> <glyph class="state variable" id="_9fc38fdd-3e8b-468c-937e-719e656abf5b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15599.0" y="934.86597"/> </glyph> <glyph class="state variable" id="_eb66ec93-5f56-4749-8a2c-467c209b78cb"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="15589.492" y="914.86597"/> </glyph> <glyph class="state variable" id="_0687b501-b9e6-4d08-94f2-324f1a07a4cc"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="15669.0" y="915.08075"/> </glyph> <glyph class="state variable" id="_d7a25c8e-13de-4a26-89f0-5785736ef272"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15599.0" y="926.58167"/> </glyph> <glyph class="state variable" id="_eca94ccd-3304-4380-9641-687c2e773e4a"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="15669.0" y="915.08075"/> </glyph> <glyph class="state variable" id="_e2844dd1-26b3-4022-80ef-ed8775ee36fd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15599.0" y="934.86597"/> </glyph> <glyph class="state variable" id="_3b09934e-904e-4ce3-832a-0a0833b0da3a"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="15668.382" y="954.86597"/> </glyph> <glyph class="state variable" id="_c344cc1d-7ea6-480a-90b8-cb5714764cc9"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="15669.0" y="915.08075"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s182_wca1_wca2_sa183" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re67:(MAP:survival) PMID:22370635 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <clone/> <bbox w="80.0" h="40.0" x="15637.0" y="2734.0"/> <glyph class="state variable" id="_71f42aef-9f4c-4e05-8070-6f79754feda8"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="15664.404" y="2769.0"/> </glyph> <glyph class="state variable" id="_4866e8f2-8c4d-46cd-8189-d70e2e3e2b2f"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="15703.882" y="2769.0"/> </glyph> <glyph class="state variable" id="_aeb1c8f7-ce54-479f-be99-d9e68d8d93f8"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="15704.5" y="2729.2148"/> </glyph> <glyph class="state variable" id="_c6ddf97f-035a-4fbc-9bfb-b574de43c71c"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="15664.532" y="2729.0"/> </glyph> <glyph class="state variable" id="_d245bc1a-c436-4ced-bf1d-b16149bcbb58"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="15624.992" y="2729.0"/> </glyph> <glyph class="state variable" id="_92103ba6-db6c-4e25-a8cd-a74c73ec10d3"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="15624.5" y="2768.7224"/> </glyph> <glyph class="state variable" id="_c33c6a3e-3268-48c2-b207-88045aa3ed2a"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="15702.0" y="2729.2148"/> </glyph> <glyph class="state variable" id="_0f4bc50a-17d1-43e9-bbe5-2e8a3e935b19"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="15702.0" y="2729.2148"/> </glyph> <glyph class="state variable" id="_27b60b82-e9ef-4d5c-a90a-d27ce7e8fe02"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15632.0" y="2749.0"/> </glyph> <glyph class="state variable" id="_cab25d9f-46ea-4418-ab85-513c175be1cb"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="15622.492" y="2729.0"/> </glyph> <glyph class="state variable" id="_0baaf802-0f5f-4d3b-aa6d-70ff772e8e61"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="15702.0" y="2729.2148"/> </glyph> <glyph class="state variable" id="_95e45662-96ad-4e22-8878-9c1988d2a776"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15632.0" y="2740.7158"/> </glyph> <glyph class="state variable" id="_2e9a2321-ed12-4139-92ac-0a00128986ad"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="15702.0" y="2729.2148"/> </glyph> <glyph class="state variable" id="_8b6e2a1f-fc08-41fa-b733-2152a9476914"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15632.0" y="2749.0"/> </glyph> <glyph class="state variable" id="_eedca5a2-3ce7-4e4a-b4dd-a33fec77aaf1"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="15701.382" y="2769.0"/> </glyph> <glyph class="state variable" id="_fb25d00e-e30c-4a32-9a43-c32ab251ca48"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="15702.0" y="2729.2148"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s268_wca1_wca2_sa182" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="123.0" h="41.0" x="15467.75" y="2788.0"/> <glyph class="state variable" id="_ebb90766-abbd-42a8-933c-8149ea4cdcb2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15585.75" y="2783.0"/> </glyph> <glyph class="state variable" id="_2e34fd72-795f-402f-bb82-ebaa1dcf3b6a"> <state value="P" variable="S849"/> <bbox w="35.0" h="10.0" x="15452.21" y="2783.0"/> </glyph> <glyph class="state variable" id="_316429e0-cfa9-4a6c-8554-71c896fa6122"> <state value="P" variable="S853"/> <bbox w="35.0" h="10.0" x="15573.25" y="2783.2202"/> </glyph> <glyph class="state variable" id="_94b02baa-b764-48e2-9a66-a57c0f03d73a"> <state value="P" variable="S855"/> <bbox w="35.0" h="10.0" x="15568.77" y="2824.0"/> </glyph> <glyph class="state variable" id="_5aa7505f-30ec-49ca-915e-093fc04ce36e"> <state value="P" variable="S840"/> <bbox w="35.0" h="10.0" x="15450.619" y="2824.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s281_wca1_wca2_sa192" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re70:(MAP:survival) PMID:23022962 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: teratocarcinoma-derived growth factor 1 HUGO:TDGF1 HGNC:11701 ENTREZ:6997 UNIPROT:P13385 GENECARDS:TDGF1 REACTOME:52798 KEGG:6997 ATLASONC:GC_TDGF1 WIKI:TDGF1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CRIPTO-1*"/> <bbox w="80.0" h="40.0" x="17620.0" y="1083.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s306_wca1_wca2_sa205" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 4 EVR1 "exudative vitreoretinopathy 1" "frizzled (Drosophila) homolog 4" "frizzled 4 seven transmembrane spanning receptor" "frizzled homolog 4 (Drosophila)" HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="FZD4"/> <bbox w="80.0" h="50.0" x="17648.0" y="1906.0"/> <glyph class="state variable" id="_bcfbffc3-a428-4775-b14c-4b9d651c7e6e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="17643.0" y="1926.0"/> </glyph> <glyph class="state variable" id="_b49454dd-5af4-430f-984e-dfe32784c1a4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="17643.0" y="1951.0"/> </glyph> <glyph class="state variable" id="_4177c547-c580-4c62-b6d3-b846dcf3d373"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="17643.0" y="1901.0"/> </glyph> <glyph class="unit of information" id="_e44a8898-34aa-4cbf-b865-cde64eb5b8bb"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="17665.5" y="1901.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s308_wca1_wca2_sa206" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 4 EVR1 "exudative vitreoretinopathy 1" "frizzled (Drosophila) homolog 4" "frizzled 4 seven transmembrane spanning receptor" "frizzled homolog 4 (Drosophila)" HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="FZD4"/> <bbox w="80.0" h="50.0" x="17648.0" y="2012.0"/> <glyph class="state variable" id="_4bffd292-a336-44ff-b42a-83edecc13185"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="17638.0" y="2032.0"/> </glyph> <glyph class="state variable" id="_1948b744-6d3b-463f-9e1b-b3214de1451b"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="17638.0" y="2057.0"/> </glyph> <glyph class="state variable" id="_2fb87321-f53d-41dc-9d71-aa312da0b7d6"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="17638.0" y="2007.0"/> </glyph> <glyph class="unit of information" id="_97452c9d-08a8-4a70-9b17-145830f95adc"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="17665.5" y="2007.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s310_wca1_wca2_sa208" compartmentRef="wca1_wca2_c4_wca1_wca2_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re78:(MAP:survival) PMID:20606702 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 4 EVR1 "exudative vitreoretinopathy 1" "frizzled (Drosophila) homolog 4" "frizzled 4 seven transmembrane spanning receptor" "frizzled homolog 4 (Drosophila)" HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="FZD4"/> <bbox w="80.0" h="50.0" x="17518.0" y="2013.0"/> <glyph class="state variable" id="_ddc46232-3029-4404-ace5-f13bede150c3"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="17508.0" y="2033.0"/> </glyph> <glyph class="state variable" id="_cb779099-2cdb-4c6a-a0e9-6f3979878be7"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="17508.0" y="2058.0"/> </glyph> <glyph class="state variable" id="_cf2424f5-d3d0-4221-a860-18a2a0b3cfdf"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="17508.0" y="2008.0"/> </glyph> <glyph class="unit of information" id="_442a9efd-2437-4ecc-9457-7070d73a6309"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="17535.5" y="2008.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s311_wca1_wca2_sa209" compartmentRef="wca1_wca2_c4_wca1_wca2_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 4 EVR1 "exudative vitreoretinopathy 1" "frizzled (Drosophila) homolog 4" "frizzled 4 seven transmembrane spanning receptor" "frizzled homolog 4 (Drosophila)" HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="FZD4"/> <bbox w="80.0" h="50.0" x="17364.0" y="2013.0"/> <glyph class="state variable" id="_6484b78c-7fbe-40cd-910b-885eaf7b1a52"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="17359.0" y="2033.0"/> </glyph> <glyph class="state variable" id="_96ac2950-d1f1-45ea-8095-3635074e46b2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="17359.0" y="2058.0"/> </glyph> <glyph class="state variable" id="_fd43aa22-c9c3-4a70-bd77-da78b326b59f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="17359.0" y="2008.0"/> </glyph> <glyph class="unit of information" id="_ca5f4048-dff7-4be5-9edf-3a7b7d0e5493"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="17381.5" y="2008.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca2_s312_wca1_wca2_sa210" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquitin specific peptidase 8 HUGO:USP8 HGNC:12631 ENTREZ:9101 UNIPROT:P40818 GENECARDS:USP8 REACTOME:66834 KEGG:9101 ATLASONC:GC_USP8 WIKI:USP8 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="USP8"/> <bbox w="80.0" h="40.0" x="17349.0" y="1907.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca2_s106_wca1_wca2_sa81"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re50:(MAP:survival) PMID:22659456 PMID:22007144 PMID:19171760 PMID:10931041 References_end</body> </html> </notes> <label text="ECM or cell-cell contact"/> <clone/> <bbox w="80.0" h="30.0" x="15382.0" y="1315.5"/> </glyph> <glyph class="phenotype" id="wca1_s_wca2_s106_wca1_wca2_sa131"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re50:(MAP:survival) PMID:22659456 PMID:22007144 PMID:19171760 PMID:10931041 References_end</body> </html> </notes> <label text="ECM or cell-cell contact"/> <clone/> <bbox w="80.0" h="30.0" x="15433.0" y="982.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca2_s139_wca1_wca2_sa108" compartmentRef="wca1_wca2_c3_wca1_wca2_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re44(MAP:survival): Only Y654-phosphorylated isoform of beta-catenin was able to indcue EMT PMID:22203675 References_end</body> </html> </notes> <label text="EMT"/> <bbox w="80.0" h="30.0" x="16280.0" y="1906.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca2_s172_wca1_wca2_sa124" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re50:(MAP:survival) PMID:22659456 PMID:22007144 PMID:19171760 PMID:10931041 s_wnc4_re24(MAP:survival): Complex of G-alpha12 and p120 stabilises binding of E-cadherin in Adhesion-complex. G-alpha12 is found back in complex with p120 and E-cadherin PMID:15240885 References_end</body> </html> </notes> <label text="Cytoskeleton"/> <bbox w="80.0" h="30.0" x="15687.0" y="1067.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca2_s80_wca1_wca2_sa62" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re29:(MAP:survival) PMID:12734397 s_wca2_re33:(MAP:survival) PMID:14747478 s_wca2_re57(MAP:survival): This complex is able to activate target genes of the canonical wnt pathway PMID:21536646 s_wca2_re61:(MAP:survival) continue with dvl puncta formation s_wca2_re63(MAP:survival): Ubiquination at this residue increases b-catenin protein stability and increased top-flash activity PMID:22705350 s_wca2_re66:(MAP:survival) The destruction is part of the canonical wnt pathway when no WNT ligand is bound to the receptor. This complex makes sure that beta-catenin is degraded. s_wca2_re71(MAP:survival): Binding of CRIPTO-1 to LRP5/6 enhances Topflash activity PMID:23022962 s_wnc1_re20(MAP:survival): Association of LGR5 w/ Wnt-receptors leads to synergistic TOPFLASH reporter activity PMID:21727895 LGR5 antagonises Wnt signalling PMID:21829496 s_wnc1_re48:(MAP:survival) PMID:21237163 s_wnc1_re69(MAP:survival): PMID:21069266 PMID:15388793 s_wnc1_re72(MAP:survival): Rack1 inhibits canonical MODULE PMID:2126816 s_wnc2_re75:(MAP:survival) PMID:18762249 s_wnc4_re6(MAP:survival): Phosphorylation of LRP6 by ERKk and simultanious activation by Wnt3 gives a higher activation rate of the canoncical wnt pathway (synergetic effect) PMID:22558232 References_end</body> </html> </notes> <label text="WNT canonical pathway"/> <bbox w="80.0" h="30.0" x="16521.0" y="954.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca2_s245_wca1_wca2_sa166" compartmentRef="wca1_wca2_c5_wca1_wca2_ca6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re59:(MAP:survival) PMID:23371553 s_wca2_re60(MAP:survival): Without RIPK4 upon wnt3 stimulation 25% of HeLa cells show DVL2 in puncta. Co-transfection of RIPK4 increases this number to more than 75% PMID:23371553 References_end</body> </html> </notes> <label text="WNT3 stimulation"/> <bbox w="80.0" h="30.0" x="17767.0" y="1417.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca2_s109_wca1_wca2_sa84" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re37:(MAP:survival) PMID:19171760 References_end</body> </html> </notes> <label text="Disruption of cell adhesion"/> <bbox w="80.0" h="30.0" x="15590.0" y="1323.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca2_s189_wca1_wca2_sa135" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re52:(MAP:survival) PMID:19244247 References_end</body> </html> </notes> <label text="WNT5-signaling"/> <bbox w="80.0" h="30.0" x="15922.0" y="1066.0"/> </glyph> <glyph class="source and sink" id="wca1_s_wca2_s27_wca1_wca2_sa24" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <label text="Proteosome"/> <bbox w="30.0" h="30.0" x="17461.0" y="1215.0"/> </glyph> <glyph class="source and sink" id="wca1_s_wca2_s313_wca1_wca2_sa211" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <label text="endosomal degradation"/> <bbox w="30.0" h="30.0" x="17547.0" y="2140.0"/> </glyph> <glyph class="complex" id="wca1_s_wca2_s5_wca1_wca2_csa1" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NKD1:_beta_-Catenin* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re1:(MAP:survival) PMID:21490931 References_end</body> </html> </notes> <label text="NKD1:β-Catenin*"/> <bbox w="100.0" h="120.0" x="15576.0" y="751.0"/> <glyph class="macromolecule" id="wca1_wca2_s4_wca1_wca2_sa4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: naked cuticle homolog 1 (Drosophila)- HUGO:NKD1 HGNC:17045 ENTREZ:85407 UNIPROT:Q969G9 GENECARDS:NKD1 KEGG:85407 ATLASONC:GC_NKD1 WIKI:NKD1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21490931 References_end</body> </html> </notes> <label text="NKD1"/> <bbox w="80.0" h="40.0" x="15587.5" y="761.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s6_wca1_wca2_sa5"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="15587.5" y="806.0"/> <glyph class="state variable" id="_c232c9a6-d472-4a01-8314-95caf8b8ef1d"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="15614.904" y="841.0"/> </glyph> <glyph class="state variable" id="_2f27b905-fe87-43db-b4c2-88a7291de552"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="15654.382" y="841.0"/> </glyph> <glyph class="state variable" id="_4cbc915a-590a-43a1-b2b5-fbd1339824a6"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="15655.0" y="801.2148"/> </glyph> <glyph class="state variable" id="_239adfdc-9ebf-4645-b037-d27b780977fa"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="15615.032" y="801.0"/> </glyph> <glyph class="state variable" id="_36ab444d-3782-4866-a13e-74c08ce4fb76"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="15575.492" y="801.0"/> </glyph> <glyph class="state variable" id="_885f3d28-2cd4-4c0b-b19d-d82897d84cc9"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="15575.0" y="840.7223"/> </glyph> <glyph class="state variable" id="_b9450ef1-7fd9-431d-a9fb-426d2b449c4d"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="15652.5" y="801.2148"/> </glyph> <glyph class="state variable" id="_80eca642-0364-40a6-a290-b5cf1aca7fba"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="15652.5" y="801.2148"/> </glyph> <glyph class="state variable" id="_aa4bf677-b332-4c31-80d5-dcbeb404d3f5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15582.5" y="821.0"/> </glyph> <glyph class="state variable" id="_171f6edb-e8e3-45e1-8615-23a904339923"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="15572.992" y="801.0"/> </glyph> <glyph class="state variable" id="_a406b33c-d869-44d3-863b-f9df23ffa851"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="15652.5" y="801.2148"/> </glyph> <glyph class="state variable" id="_81fc14ab-f496-4925-abc6-ddbe0d11f16d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15582.5" y="812.7157"/> </glyph> <glyph class="state variable" id="_472784d4-1674-4679-9c88-22c097134d10"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="15652.5" y="801.2148"/> </glyph> <glyph class="state variable" id="_69e2950c-c26b-4f6c-bf57-8bdadbae23bd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15582.5" y="821.0"/> </glyph> <glyph class="state variable" id="_ef5123d3-f634-4676-9d3d-6d78bce8ad85"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="15651.882" y="841.0"/> </glyph> <glyph class="state variable" id="_4a543930-4adb-4afe-acfb-b4c8c0b47f6d"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="15652.5" y="801.2148"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s8_wca1_wca2_csa2" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DVL2:NKD1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re2:(MAP:survival) PMID:21490931 References_end</body> </html> </notes> <label text="DVL2:NKD1"/> <bbox w="100.0" h="120.0" x="15866.5" y="751.0"/> <glyph class="macromolecule" id="wca1_wca2_s9_wca1_wca2_sa7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: dishevelled dsh homolog 2 (Drosophila) "dishevelled 2 (homologous to Drosophila dsh)" HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:16273260 References_end</body> </html> </notes> <label text="DVL2"/> <bbox w="80.0" h="40.0" x="15877.5" y="808.0"/> <glyph class="state variable" id="_c4e0d401-a148-426f-b24f-6d68329cd870"> <state value="" variable="S480"/> <bbox w="30.0" h="10.0" x="15862.992" y="803.0"/> </glyph> <glyph class="state variable" id="_d43547f0-1c7a-4534-8124-b53e4440cdf3"> <state value="" variable="S298"/> <bbox w="30.0" h="10.0" x="15862.5" y="842.7223"/> </glyph> <glyph class="state variable" id="_ded97536-a055-47cb-a44d-0e523ee77852"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15952.5" y="803.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s7_wca1_wca2_sa8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: naked cuticle homolog 1 (Drosophila)- HUGO:NKD1 HGNC:17045 ENTREZ:85407 UNIPROT:Q969G9 GENECARDS:NKD1 KEGG:85407 ATLASONC:GC_NKD1 WIKI:NKD1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21490931 References_end</body> </html> </notes> <label text="NKD1"/> <bbox w="80.0" h="40.0" x="15877.5" y="764.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s36_wca1_wca2_csa5" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DKK1:KRM*:LRP5_6* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re20(MAP:survival): PMID:11433302 PMID:11448771 PMID:12050670 s_wca2_re22:(MAP:survival) PMID:20543981 s_wca2_re24:(MAP:survival) PMID:17804805 References_end</body> </html> </notes> <label text="DKK1:KRM*:LRP5_6*"/> <bbox w="150.0" h="100.0" x="16298.0" y="720.0"/> <glyph class="macromolecule" id="wca1_wca2_s70_wca1_wca2_sa33"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: dickkopf 1 homolog (Xenopus laevis) "dickkopf (Xenopus laevis) homolog 1" HUGO:DKK1 HGNC:2891 ENTREZ:22943 UNIPROT:O94907 GENECARDS:DKK1 KEGG:22943 ATLASONC:DKK1ID44007ch10q11 WIKI:DKK1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22807036 References_end</body> </html> </notes> <label text="DKK1"/> <bbox w="40.0" h="20.0" x="16328.0" y="730.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s71_wca1_wca2_sa34"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="16308.0" y="745.0"/> <glyph class="state variable" id="_ee1ab48b-d25c-4572-9563-f4740fcff8ac"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="16290.5" y="764.9602"/> </glyph> <glyph class="state variable" id="_24bf552f-8b3d-4377-bff9-a3e1cb8408f0"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="16330.532" y="740.0"/> </glyph> <glyph class="state variable" id="_5962bf9d-c2bc-4ea4-85da-b9765d446828"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="16370.5" y="740.26843"/> </glyph> <glyph class="state variable" id="_00249cf1-cd6c-4933-b356-484dc12df373"> <state value="" variable="S1496"/> <bbox w="35.0" h="10.0" x="16369.882" y="790.0"/> </glyph> <glyph class="state variable" id="_c5f0a175-c7f9-4bca-9f7b-8fba406d0537"> <state value="" variable="T1530"/> <bbox w="35.0" h="10.0" x="16329.6045" y="790.0"/> </glyph> <glyph class="state variable" id="_d255a677-ea5f-4881-be7d-a5df59150ba1"> <state value="" variable="S1533"/> <bbox w="35.0" h="10.0" x="16290.74" y="790.0"/> </glyph> <glyph class="unit of information" id="_04f7b124-f065-49ea-a8f0-cfca8fa43a79"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="16325.5" y="740.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s72_wca1_wca2_sa54"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: kringle containing transmembrane protein 1 HUGO:KREMEN1 HGNC:17550 ENTREZ:83999 UNIPROT:Q96MU8 GENECARDS:KREMEN1 KEGG:83999 WIKI:KREMEN1 kringle containing transmembrane protein 2 HUGO:KREMEN2 HGNC:18797 ENTREZ:79412 UNIPROT:Q8NCW0 GENECARDS:KREMEN2 KEGG:79412 WIKI:KREMEN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="KRM*"/> <bbox w="35.0" h="60.0" x="16390.5" y="740.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s47_wca1_wca2_csa6" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:WNT* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re25(MAP:survival): Kremen interacts w/ RSPO1 thereby releasing LRP5/6 which can is used for canonical wnt signalling PMID:12050670 s_wca2_re21(MAP:survival): DKK1 can disrupt binding of Fz/LRP6/WNT complex PMID:11448771 References_end</body> </html> </notes> <label text="E-Cadherin*:FZD*:GTP:Gαo*:Gβ*:Gγ*:LRP5_6*:WNT*"/> <bbox w="200.0" h="170.0" x="16458.0" y="685.0"/> <glyph class="macromolecule" id="wca1_wca2_s286_wca1_wca2_sa35"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="16498.0" y="755.0"/> <glyph class="state variable" id="_6e25460a-7c06-4248-9df7-15e7800a72a1"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="16480.5" y="774.9602"/> </glyph> <glyph class="state variable" id="_2af6fb85-4709-40ff-b5a4-eb83a3574e0a"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="16520.531" y="750.0"/> </glyph> <glyph class="state variable" id="_1eb81b6a-c523-492a-aed0-8dc87dc05540"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="16560.5" y="750.26843"/> </glyph> <glyph class="state variable" id="_e1f4af27-f1e4-456a-a17d-b3da7d0f055a"> <state value="" variable="S1496"/> <bbox w="35.0" h="10.0" x="16559.88" y="800.0"/> </glyph> <glyph class="state variable" id="_1252bcb2-5318-4890-a10e-59c7ccf32fb6"> <state value="" variable="T1530"/> <bbox w="35.0" h="10.0" x="16519.604" y="800.0"/> </glyph> <glyph class="state variable" id="_f4f007c7-4f90-4242-870e-a647e5061bf7"> <state value="" variable="S1533"/> <bbox w="35.0" h="10.0" x="16480.74" y="800.0"/> </glyph> <glyph class="unit of information" id="_26841fe2-4479-4298-bf38-6c783ea0c88c"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="16515.5" y="750.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s287_wca1_wca2_sa36"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="16498.0" y="715.0"/> <glyph class="unit of information" id="_3a7b317d-99a5-4b85-9d29-b3d348b1fde2"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="16515.5" y="710.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s288_wca1_wca2_sa37"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="30.0" h="20.0" x="16523.0" y="705.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s289_wca1_wca2_sa38"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="53.0" h="123.0" x="16581.5" y="693.5"/> <glyph class="state variable" id="_7504a4f1-ab27-49a9-ae7c-5ced4c54c45b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16629.5" y="688.5"/> </glyph> <glyph class="state variable" id="_b58f34f4-fd83-40f9-8a74-72269f586880"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="16567.344" y="688.5"/> </glyph> <glyph class="state variable" id="_8129f43c-c02e-4d92-9101-ec3e48dd2c2d"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="16619.5" y="689.1604"/> </glyph> <glyph class="state variable" id="_028ff3a9-08b4-43a4-916e-27724dcb875e"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="16617.568" y="811.5"/> </glyph> <glyph class="state variable" id="_99677370-a444-4772-8aa6-313cd08e0ef2"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="16566.658" y="811.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s290_wca1_wca2_sa39"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein) alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 (Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 guanine nucleotide binding protein (G protein) alpha activating activity polypeptide olfactory type HUGO:GNAL HGNC:4388 ENTREZ:2774 UNIPROT:P38405 GENECARDS:GNAL REACTOME:55364 ATLASONC:GC_GNAL WIKI:GNAL guanine nucleotide binding protein (G protein) alpha activating activity polypeptide O HUGO:GNAO1 HGNC:4389 ENTREZ:2775 UNIPROT:P09471 GENECARDS:GNAO1 REACTOME:55350 KEGG:2775 ATLASONC:GC_GNAO1 WIKI:GNAO1 guanine nucleotide binding protein (G protein) q polypeptide HUGO:GNAQ HGNC:4390 ENTREZ:2776 UNIPROT:P50148 GENECARDS:GNAQ REACTOME:55454 KEGG:2776 ATLASONC:GNAQID43280ch9q21 WIKI:GNAQ Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21640127 References_end</body> </html> </notes> <label text="Gαo*"/> <bbox w="30.0" h="20.0" x="16478.0" y="815.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s291_wca1_wca2_sa40"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="30.0" h="20.0" x="16518.0" y="815.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s292_wca1_wca2_sa41"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="30.0" h="20.0" x="16558.0" y="815.0"/> </glyph> <glyph class="simple chemical" id="wca1_wca2_s293_wca1_wca2_sa42"> <label text="GTP"/> <bbox w="25.0" h="25.0" x="16475.5" y="792.5"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s58_wca1_wca2_csa7" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:WNT* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re21(MAP:survival): DKK1 can disrupt binding of Fz/LRP6/WNT complex PMID:11448771 s_wca2_re72(MAP:survival): Upon WNT3a CRIPTO-1 binds to LRP5/6 this binding is competing with DKK binding PMID:23022962 References_end</body> </html> </notes> <label text="E-Cadherin*:FZD*:GTP:Gαo*:Gβ*:Gγ*:WNT*"/> <bbox w="200.0" h="170.0" x="16777.0" y="688.0"/> <glyph class="macromolecule" id="wca1_wca2_s59_wca1_wca2_sa44"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="30.0" h="20.0" x="16842.0" y="708.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s60_wca1_wca2_sa45"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="53.0" h="123.0" x="16900.5" y="696.5"/> <glyph class="state variable" id="_f8044eb6-c3c7-4177-b57e-116bd00bdc16"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16948.5" y="691.5"/> </glyph> <glyph class="state variable" id="_c4ce35f0-0a02-4f7d-85a8-f382d1d2a4af"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="16886.344" y="691.5"/> </glyph> <glyph class="state variable" id="_1943d7fc-446b-4050-8461-e51b0ec7801c"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="16938.5" y="692.1604"/> </glyph> <glyph class="state variable" id="_c2df9d0d-2a8d-4d2d-8cb6-aaa7fecb8bc8"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="16936.568" y="814.5"/> </glyph> <glyph class="state variable" id="_d58ce852-2505-495e-a905-787614f29e5a"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="16885.658" y="814.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s61_wca1_wca2_sa46"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein) alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 (Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 guanine nucleotide binding protein (G protein) alpha activating activity polypeptide olfactory type HUGO:GNAL HGNC:4388 ENTREZ:2774 UNIPROT:P38405 GENECARDS:GNAL REACTOME:55364 ATLASONC:GC_GNAL WIKI:GNAL guanine nucleotide binding protein (G protein) alpha activating activity polypeptide O HUGO:GNAO1 HGNC:4389 ENTREZ:2775 UNIPROT:P09471 GENECARDS:GNAO1 REACTOME:55350 KEGG:2775 ATLASONC:GC_GNAO1 WIKI:GNAO1 guanine nucleotide binding protein (G protein) q polypeptide HUGO:GNAQ HGNC:4390 ENTREZ:2776 UNIPROT:P50148 GENECARDS:GNAQ REACTOME:55454 KEGG:2776 ATLASONC:GNAQID43280ch9q21 WIKI:GNAQ Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21640127 References_end</body> </html> </notes> <label text="Gαo*"/> <bbox w="30.0" h="20.0" x="16797.0" y="818.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s62_wca1_wca2_sa47"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="30.0" h="20.0" x="16837.0" y="818.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s63_wca1_wca2_sa48"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="30.0" h="20.0" x="16877.0" y="818.0"/> </glyph> <glyph class="simple chemical" id="wca1_wca2_s64_wca1_wca2_sa49"> <label text="GTP"/> <bbox w="25.0" h="25.0" x="16794.5" y="795.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s65_wca1_wca2_sa50"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="16817.0" y="718.0"/> <glyph class="unit of information" id="_1a048c5b-fe23-48cd-9c49-e1b66aca00ba"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="16834.5" y="713.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s69_wca1_wca2_csa8" compartmentRef="wca1_wca2_c2_wca1_wca2_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DKK1:KRM*:LRP5_6* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re22:(MAP:survival) PMID:20543981 References_end</body> </html> </notes> <label text="DKK1:KRM*:LRP5_6*"/> <bbox w="150.0" h="100.0" x="16228.0" y="963.0"/> <glyph class="macromolecule" id="wca1_wca2_s38_wca1_wca2_sa55"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: dickkopf 1 homolog (Xenopus laevis) "dickkopf (Xenopus laevis) homolog 1" HUGO:DKK1 HGNC:2891 ENTREZ:22943 UNIPROT:O94907 GENECARDS:DKK1 KEGG:22943 ATLASONC:DKK1ID44007ch10q11 WIKI:DKK1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22807036 References_end</body> </html> </notes> <label text="DKK1"/> <bbox w="40.0" h="20.0" x="16258.0" y="973.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s37_wca1_wca2_sa56"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="16238.0" y="988.0"/> <glyph class="state variable" id="_4bd9b7ed-ee03-4597-b9cb-a3df103e2d11"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="16220.5" y="1007.9602"/> </glyph> <glyph class="state variable" id="_16c14cd3-4a57-4e93-af83-cbd39e9d874c"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="16260.532" y="983.0"/> </glyph> <glyph class="state variable" id="_94648da1-bf44-4022-878a-f0fc4f35bdcf"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="16300.5" y="983.26843"/> </glyph> <glyph class="state variable" id="_69cfa5e6-e010-4715-a289-82d4f93578d8"> <state value="" variable="S1496"/> <bbox w="35.0" h="10.0" x="16299.882" y="1033.0"/> </glyph> <glyph class="state variable" id="_9f558f9a-a2fb-43eb-acc7-d71b80c55fde"> <state value="" variable="T1530"/> <bbox w="35.0" h="10.0" x="16259.6045" y="1033.0"/> </glyph> <glyph class="state variable" id="_0543b039-66b0-4b6e-8270-dd8429751432"> <state value="" variable="S1533"/> <bbox w="35.0" h="10.0" x="16220.74" y="1033.0"/> </glyph> <glyph class="unit of information" id="_a19160da-5ad8-48d1-a2f7-8efee2522a08"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="16255.5" y="983.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s68_wca1_wca2_sa57"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: kringle containing transmembrane protein 1 HUGO:KREMEN1 HGNC:17550 ENTREZ:83999 UNIPROT:Q96MU8 GENECARDS:KREMEN1 KEGG:83999 WIKI:KREMEN1 kringle containing transmembrane protein 2 HUGO:KREMEN2 HGNC:18797 ENTREZ:79412 UNIPROT:Q8NCW0 GENECARDS:KREMEN2 KEGG:79412 WIKI:KREMEN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="KRM*"/> <bbox w="35.0" h="60.0" x="16320.5" y="983.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s76_wca1_wca2_csa9" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:KRM*:RSPO1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re24:(MAP:survival) PMID:17804805 References_end</body> </html> </notes> <label text="KRM*:RSPO1"/> <bbox w="130.0" h="110.0" x="16993.0" y="727.0"/> <glyph class="macromolecule" id="wca1_wca2_s78_wca1_wca2_sa59"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: kringle containing transmembrane protein 1 HUGO:KREMEN1 HGNC:17550 ENTREZ:83999 UNIPROT:Q96MU8 GENECARDS:KREMEN1 KEGG:83999 WIKI:KREMEN1 kringle containing transmembrane protein 2 HUGO:KREMEN2 HGNC:18797 ENTREZ:79412 UNIPROT:Q8NCW0 GENECARDS:KREMEN2 KEGG:79412 WIKI:KREMEN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="KRM*"/> <bbox w="35.0" h="60.0" x="17075.5" y="757.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s77_wca1_wca2_sa60"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: R-spondin 1 "R-spondin homolog (Xenopus laevis)" HUGO:RSPO1 HGNC:21679 ENTREZ:284654 UNIPROT:Q2MKA7 GENECARDS:RSPO1 KEGG:284654 ATLASONC:RSPO1ID44137ch1p34 WIKI:RSPO1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RSPO1"/> <bbox w="80.0" h="40.0" x="16996.0" y="764.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s85_wca1_wca2_csa10" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DKK3:KRM* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re26:(MAP:survival) PMID:20370576 References_end</body> </html> </notes> <label text="DKK3:KRM*"/> <bbox w="60.0" h="120.0" x="15998.0" y="700.0"/> <glyph class="macromolecule" id="wca1_wca2_s89_wca1_wca2_sa65"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: dickkopf 3 homolog (Xenopus laevis) HUGO:DKK3 HGNC:2893 ENTREZ:27122 UNIPROT:Q9UBP4 GENECARDS:DKK3 KEGG:27122 ATLASONC:GC_DKK3 WIKI:DKK3 "dickkopf (Xenopus laevis) homolog 3" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="DKK3"/> <bbox w="40.0" h="20.0" x="16008.0" y="720.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s90_wca1_wca2_sa66"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: kringle containing transmembrane protein 1 HUGO:KREMEN1 HGNC:17550 ENTREZ:83999 UNIPROT:Q96MU8 GENECARDS:KREMEN1 KEGG:83999 WIKI:KREMEN1 kringle containing transmembrane protein 2 HUGO:KREMEN2 HGNC:18797 ENTREZ:79412 UNIPROT:Q8NCW0 GENECARDS:KREMEN2 KEGG:79412 WIKI:KREMEN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="KRM*"/> <bbox w="35.0" h="60.0" x="16010.5" y="740.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s88_wca1_wca2_csa11" compartmentRef="wca1_wca2_c2_wca1_wca2_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DKK3:KRM* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re27:(MAP:survival) PMID:20370576 References_end</body> </html> </notes> <label text="DKK3:KRM*"/> <bbox w="60.0" h="120.0" x="16133.0" y="963.0"/> <glyph class="macromolecule" id="wca1_wca2_s87_wca1_wca2_sa67"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: dickkopf 3 homolog (Xenopus laevis) HUGO:DKK3 HGNC:2893 ENTREZ:27122 UNIPROT:Q9UBP4 GENECARDS:DKK3 KEGG:27122 ATLASONC:GC_DKK3 WIKI:DKK3 "dickkopf (Xenopus laevis) homolog 3" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="DKK3"/> <bbox w="40.0" h="20.0" x="16143.0" y="983.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s86_wca1_wca2_sa68"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: kringle containing transmembrane protein 1 HUGO:KREMEN1 HGNC:17550 ENTREZ:83999 UNIPROT:Q96MU8 GENECARDS:KREMEN1 KEGG:83999 WIKI:KREMEN1 kringle containing transmembrane protein 2 HUGO:KREMEN2 HGNC:18797 ENTREZ:79412 UNIPROT:Q8NCW0 GENECARDS:KREMEN2 KEGG:79412 WIKI:KREMEN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="KRM*"/> <bbox w="35.0" h="60.0" x="16145.5" y="1003.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s114_wca1_wca2_csa15" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TGFB1:TGFBR* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re37:(MAP:survival) PMID:19171760 s_wca2_re48:(MAP:survival) part of canonical TGF pathway References_end</body> </html> </notes> <label text="TGFB1:TGFBR*"/> <bbox w="100.0" h="120.0" x="15472.0" y="1671.0"/> <glyph class="macromolecule" id="wca1_wca2_s112_wca1_wca2_sa87"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transforming growth factor beta receptor 1 HUGO:TGFBR1 HGNC:11772 ENTREZ:7046 UNIPROT:P36897 GENECARDS:TGFBR1 REACTOME:65969 KEGG:7046 ATLASONC:GC_TGFBR1 WIKI:TGFBR1 transforming growth factor beta receptor 2 HUGO:TGFBR2 HGNC:11773 ENTREZ:7048 UNIPROT:P37173 GENECARDS:TGFBR2 REACTOME:65971 KEGG:7048 ATLASONC:GC_TGFBR2 WIKI:TGFBR2 transforming growth factor beta receptor 3 HUGO:TGFBR3 HGNC:11774 ENTREZ:7049 UNIPROT:Q03167 GENECARDS:TGFBR3 KEGG:7049 ATLASONC:TGFBR3ID42541ch1p33 WIKI:TGFBR3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TGFBR*"/> <bbox w="80.0" h="50.0" x="15481.0" y="1714.0"/> <glyph class="unit of information" id="_6389ff59-c937-44c4-aa8b-0dbc98888267"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="15498.5" y="1709.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s113_wca1_wca2_sa88"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transforming growth factor beta 1 HUGO:TGFB1 HGNC:11766 ENTREZ:7040 UNIPROT:P01137 GENECARDS:TGFB1 REACTOME:65937 KEGG:7040 ATLASONC:GC_TGFB1 WIKI:TGFB1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:emtcellmotility / MODULE:ECM MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TGFB1"/> <bbox w="52.0" h="29.0" x="15494.0" y="1690.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s125_wca1_wca2_csa16" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:E-Cadherin*:ITGA3:TGFB1:TGFBR*:_beta_-Catenin*:p120* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re37:(MAP:survival) PMID:19171760 References_end</body> </html> </notes> <label text="E-Cadherin*:ITGA3:TGFB1:TGFBR*:β-Catenin*:p120*"/> <bbox w="202.0" h="249.0" x="15418.0" y="1385.5"/> <glyph class="macromolecule" id="wca1_wca2_s127_wca1_wca2_sa89"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: integrin alpha 3 (antigen CD49C alpha 3 subunit of VLA-3 receptor) "antigen identified by monoclonal antibody J143" MSK18 HUGO:ITGA3 HGNC:6139 ENTREZ:3675 UNIPROT:P26006 GENECARDS:ITGA3 REACTOME:57565 KEGG:3675 ATLASONC:GC_ITGA3 WIKI:ITGA3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_MATRIX_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ITGA3"/> <bbox w="80.0" h="40.0" x="15500.0" y="1397.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s210_wca1_wca2_sa90"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="123.0" h="41.0" x="15440.0" y="1443.5"/> <glyph class="state variable" id="_f73afa9a-19bd-4066-b161-529d389e46a7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15558.0" y="1438.5"/> </glyph> <glyph class="state variable" id="_6859acac-2124-4626-a38e-929a34109cc0"> <state value="P" variable="S849"/> <bbox w="35.0" h="10.0" x="15424.46" y="1438.5"/> </glyph> <glyph class="state variable" id="_e8e4262b-2cb4-4057-b3a2-a5a9c089fae5"> <state value="P" variable="S853"/> <bbox w="35.0" h="10.0" x="15545.5" y="1438.7201"/> </glyph> <glyph class="state variable" id="_fa7b51a0-fc57-4d1d-8ea3-87e9d54179fd"> <state value="P" variable="S855"/> <bbox w="35.0" h="10.0" x="15541.02" y="1479.5"/> </glyph> <glyph class="state variable" id="_36465232-bb2a-4eb3-8961-a6a5d8ab3333"> <state value="P" variable="S840"/> <bbox w="35.0" h="10.0" x="15422.869" y="1479.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s129_wca1_wca2_sa91"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="15436.0" y="1491.5"/> <glyph class="state variable" id="_7e6f988e-6519-437f-9d9e-9e0a5b1546e1"> <state value="" variable="S268"/> <bbox w="30.0" h="10.0" x="15421.492" y="1486.5"/> </glyph> <glyph class="state variable" id="_ccf6873e-ceae-46a7-bbef-767619e3ba90"> <state value="" variable="S269"/> <bbox w="30.0" h="10.0" x="15461.032" y="1486.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s185_wca1_wca2_sa92"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="15531.0" y="1490.5"/> <glyph class="state variable" id="_a1ce0fb0-30ba-4e06-a077-9c33bbbb5021"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="15558.404" y="1525.5"/> </glyph> <glyph class="state variable" id="_260e5d67-fd40-41ea-aefa-420ae176a598"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="15597.882" y="1525.5"/> </glyph> <glyph class="state variable" id="_def461f4-5a36-4b25-900d-5150775b8dca"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="15598.5" y="1485.7147"/> </glyph> <glyph class="state variable" id="_8d8d07d8-971a-4729-a34a-a3348a12ad93"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="15558.532" y="1485.5"/> </glyph> <glyph class="state variable" id="_6559c715-d232-47a5-aef2-c88066f83b31"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="15518.992" y="1485.5"/> </glyph> <glyph class="state variable" id="_cfc5097b-e04c-46d2-a502-69079055bbdd"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="15518.5" y="1525.2223"/> </glyph> <glyph class="state variable" id="_8afd3377-e496-4aca-886c-1613e960b670"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="15596.0" y="1485.7147"/> </glyph> <glyph class="state variable" id="_76c14303-1cfc-4f5b-bc69-9061ce8e4f0a"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="15596.0" y="1485.7147"/> </glyph> <glyph class="state variable" id="_7b9cfd31-1f7c-4802-80ba-9ee44fcc7b60"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15526.0" y="1505.5"/> </glyph> <glyph class="state variable" id="_0e49baa0-4341-4ab7-bc09-44adeee53734"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="15516.492" y="1485.5"/> </glyph> <glyph class="state variable" id="_2d928fe0-c1c8-4b1e-99ac-800ee71c117c"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="15596.0" y="1485.7147"/> </glyph> <glyph class="state variable" id="_b8f321a3-ffe3-4299-aa1a-d5fe53d95143"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15526.0" y="1497.2157"/> </glyph> <glyph class="state variable" id="_fc11afd9-833d-4d8b-8f50-bfdedbdf05cf"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="15596.0" y="1485.7147"/> </glyph> <glyph class="state variable" id="_9d55a324-09a9-4d50-9c81-f08ad74b23b6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15526.0" y="1505.5"/> </glyph> <glyph class="state variable" id="_a49aae4d-d41f-451d-8e5a-c56c6f3bea30"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="15595.382" y="1525.5"/> </glyph> <glyph class="state variable" id="_7d2017ef-7efe-4a2c-ae60-e5ac086bbcf5"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="15596.0" y="1485.7147"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s131_wca1_wca2_sa94"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transforming growth factor beta 1 HUGO:TGFB1 HGNC:11766 ENTREZ:7040 UNIPROT:P01137 GENECARDS:TGFB1 REACTOME:65937 KEGG:7040 ATLASONC:GC_TGFB1 WIKI:TGFB1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:emtcellmotility / MODULE:ECM MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TGFB1"/> <bbox w="52.0" h="29.0" x="15493.0" y="1538.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s132_wca1_wca2_sa95"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transforming growth factor beta receptor 1 HUGO:TGFBR1 HGNC:11772 ENTREZ:7046 UNIPROT:P36897 GENECARDS:TGFBR1 REACTOME:65969 KEGG:7046 ATLASONC:GC_TGFBR1 WIKI:TGFBR1 transforming growth factor beta receptor 2 HUGO:TGFBR2 HGNC:11773 ENTREZ:7048 UNIPROT:P37173 GENECARDS:TGFBR2 REACTOME:65971 KEGG:7048 ATLASONC:GC_TGFBR2 WIKI:TGFBR2 transforming growth factor beta receptor 3 HUGO:TGFBR3 HGNC:11774 ENTREZ:7049 UNIPROT:Q03167 GENECARDS:TGFBR3 KEGG:7049 ATLASONC:TGFBR3ID42541ch1p33 WIKI:TGFBR3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TGFBR*"/> <bbox w="80.0" h="50.0" x="15480.0" y="1547.5"/> <glyph class="unit of information" id="_a47306a4-1867-4fc7-8b59-19ae8b5739ed"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="15497.5" y="1542.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s126_wca1_wca2_csa17" compartmentRef="wca1_wca2_c2_wca1_wca2_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:E-Cadherin*:ITGA3:TGFB1:TGFBR*:_beta_-Catenin*:p120* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re38:(MAP:survival) PMID:19171760 s_wca2_re39(MAP:survival): Integrin alphaIII beta1 can activate Src PMID:22203675 Other integrin family member activates as well Src PMID:19734908 s_wca2_re45(MAP:survival): Src phosphorylates Y654 residue on b-catenin PMID:16099633 References_end</body> </html> </notes> <label text="E-Cadherin*:ITGA3:TGFB1:TGFBR*:β-Catenin*:p120*"/> <bbox w="202.0" h="249.0" x="15983.0" y="1367.0"/> <glyph class="macromolecule" id="wca1_wca2_s141_wca1_wca2_sa96"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: integrin alpha 3 (antigen CD49C alpha 3 subunit of VLA-3 receptor) "antigen identified by monoclonal antibody J143" MSK18 HUGO:ITGA3 HGNC:6139 ENTREZ:3675 UNIPROT:P26006 GENECARDS:ITGA3 REACTOME:57565 KEGG:3675 ATLASONC:GC_ITGA3 WIKI:ITGA3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_MATRIX_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ITGA3"/> <bbox w="80.0" h="40.0" x="16065.0" y="1379.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s142_wca1_wca2_sa97"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="123.0" h="41.0" x="16005.0" y="1425.0"/> <glyph class="state variable" id="_4ee1869e-bfe1-4055-aa0b-2bc040995404"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16123.0" y="1420.0"/> </glyph> <glyph class="state variable" id="_3e2001e5-48be-4fb4-bc5e-2a076a885672"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="15991.96" y="1420.0"/> </glyph> <glyph class="state variable" id="_426944f9-465d-4d17-bd08-a41611782c9b"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="16113.0" y="1420.2201"/> </glyph> <glyph class="state variable" id="_23ca11e1-fb67-467c-aa88-9681fba410d6"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="16108.52" y="1461.0"/> </glyph> <glyph class="state variable" id="_e0d9466e-b80f-440c-b867-0d9a1c4823f4"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="15990.369" y="1461.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s143_wca1_wca2_sa98"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="16001.0" y="1473.0"/> <glyph class="state variable" id="_45dd5f1c-acb9-4e3e-961d-5ae658bce9b2"> <state value="" variable="S268"/> <bbox w="30.0" h="10.0" x="15986.492" y="1468.0"/> </glyph> <glyph class="state variable" id="_b6181857-31b3-450a-961b-7cf596ae00f8"> <state value="" variable="S269"/> <bbox w="30.0" h="10.0" x="16026.032" y="1468.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s186_wca1_wca2_sa99"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="16079.0" y="1471.0"/> <glyph class="state variable" id="_6d18e395-d92f-42f4-89e3-2be2aef35348"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="16106.404" y="1506.0"/> </glyph> <glyph class="state variable" id="_e9985b3f-8332-4fdd-9617-9a61f3bf5a15"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="16145.882" y="1506.0"/> </glyph> <glyph class="state variable" id="_45ba414d-23c3-4ca4-b449-b87be51ea91f"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="16146.5" y="1466.2147"/> </glyph> <glyph class="state variable" id="_00051039-e7de-405d-ae86-b6c4019a6365"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="16106.532" y="1466.0"/> </glyph> <glyph class="state variable" id="_77858e03-c6ef-40ed-a27d-901df2714eca"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="16066.992" y="1466.0"/> </glyph> <glyph class="state variable" id="_4ef5d336-70c6-436f-8a5e-c0a5ca5699a4"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="16066.5" y="1505.7223"/> </glyph> <glyph class="state variable" id="_fd6e4a87-ce9a-4765-bc54-00a8f8e2fa80"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="16144.0" y="1466.2147"/> </glyph> <glyph class="state variable" id="_39a86a05-a3c3-4c0f-b920-75df6a57aabb"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="16144.0" y="1466.2147"/> </glyph> <glyph class="state variable" id="_4c249a1b-f3da-4f61-8e94-bc0986340f08"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16074.0" y="1486.0"/> </glyph> <glyph class="state variable" id="_9fc655fa-a2e7-4404-91a6-06b33058ee4c"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="16064.492" y="1466.0"/> </glyph> <glyph class="state variable" id="_dab6c850-16f6-468b-85cb-98a6b0cc6c2e"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="16144.0" y="1466.2147"/> </glyph> <glyph class="state variable" id="_3e806642-3b36-416f-97c5-03879bad8cda"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16074.0" y="1477.7157"/> </glyph> <glyph class="state variable" id="_0fd38928-0090-433d-a1a4-970ca7c5ace5"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="16144.0" y="1466.2147"/> </glyph> <glyph class="state variable" id="_0e36ff09-dbb9-4c04-afba-36b8e0038edf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16074.0" y="1486.0"/> </glyph> <glyph class="state variable" id="_46ecef9f-00f5-4b85-af15-41824bc0be38"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="16143.382" y="1506.0"/> </glyph> <glyph class="state variable" id="_cd094038-4ee6-45f8-8b03-89c76bb0b62a"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="16144.0" y="1466.2147"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s145_wca1_wca2_sa100"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transforming growth factor beta 1 HUGO:TGFB1 HGNC:11766 ENTREZ:7040 UNIPROT:P01137 GENECARDS:TGFB1 REACTOME:65937 KEGG:7040 ATLASONC:GC_TGFB1 WIKI:TGFB1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:emtcellmotility / MODULE:ECM MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TGFB1"/> <bbox w="52.0" h="29.0" x="16058.0" y="1505.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s146_wca1_wca2_sa101"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transforming growth factor beta receptor 1 HUGO:TGFBR1 HGNC:11772 ENTREZ:7046 UNIPROT:P36897 GENECARDS:TGFBR1 REACTOME:65969 KEGG:7046 ATLASONC:GC_TGFBR1 WIKI:TGFBR1 transforming growth factor beta receptor 2 HUGO:TGFBR2 HGNC:11773 ENTREZ:7048 UNIPROT:P37173 GENECARDS:TGFBR2 REACTOME:65971 KEGG:7048 ATLASONC:GC_TGFBR2 WIKI:TGFBR2 transforming growth factor beta receptor 3 HUGO:TGFBR3 HGNC:11774 ENTREZ:7049 UNIPROT:Q03167 GENECARDS:TGFBR3 KEGG:7049 ATLASONC:TGFBR3ID42541ch1p33 WIKI:TGFBR3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TGFBR*"/> <bbox w="80.0" h="50.0" x="16045.0" y="1529.0"/> <glyph class="unit of information" id="_bccfa3c9-01ef-4c67-8a14-697fc304effe"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="16062.5" y="1524.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s147_wca1_wca2_csa18" compartmentRef="wca1_wca2_c2_wca1_wca2_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:E-Cadherin*:ITGA3:TGFB1:TGFBR*:_beta_-Catenin*:p120* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re45(MAP:survival): Src phosphorylates Y654 residue on b-catenin PMID:16099633 s_wca2_re46:(MAP:survival) PMID:22203675 References_end</body> </html> </notes> <label text="E-Cadherin*:ITGA3:TGFB1:TGFBR*:β-Catenin*:p120*"/> <bbox w="202.0" h="249.0" x="16264.0" y="1367.0"/> <glyph class="macromolecule" id="wca1_wca2_s155_wca1_wca2_sa109"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: integrin alpha 3 (antigen CD49C alpha 3 subunit of VLA-3 receptor) "antigen identified by monoclonal antibody J143" MSK18 HUGO:ITGA3 HGNC:6139 ENTREZ:3675 UNIPROT:P26006 GENECARDS:ITGA3 REACTOME:57565 KEGG:3675 ATLASONC:GC_ITGA3 WIKI:ITGA3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_MATRIX_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ITGA3"/> <bbox w="80.0" h="40.0" x="16346.0" y="1379.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s156_wca1_wca2_sa110"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="123.0" h="41.0" x="16286.0" y="1425.0"/> <glyph class="state variable" id="_c616faff-8fed-4640-9bcb-413a43d745ed"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16404.0" y="1420.0"/> </glyph> <glyph class="state variable" id="_ef6aadfd-6e7d-456c-aaad-18d3a55b8a8d"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="16272.96" y="1420.0"/> </glyph> <glyph class="state variable" id="_56802287-b905-4d0a-8329-d12ae6da7aa6"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="16394.0" y="1420.2201"/> </glyph> <glyph class="state variable" id="_b540ca46-d347-427c-ba87-72a61034983f"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="16389.52" y="1461.0"/> </glyph> <glyph class="state variable" id="_2a6beca4-c474-4d5c-bf23-ace2cd29dcec"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="16271.369" y="1461.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s157_wca1_wca2_sa111"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="16282.0" y="1473.0"/> <glyph class="state variable" id="_8d2b8b1f-3dd7-4e3a-8d85-c6a65d33de9f"> <state value="" variable="S268"/> <bbox w="30.0" h="10.0" x="16267.492" y="1468.0"/> </glyph> <glyph class="state variable" id="_6a79033f-42dc-43cf-9d60-5d93d406c630"> <state value="" variable="S269"/> <bbox w="30.0" h="10.0" x="16307.032" y="1468.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s187_wca1_wca2_sa112"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="16364.0" y="1468.0"/> <glyph class="state variable" id="_23017fd7-7c06-4444-ad05-427c95fb7530"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="16391.404" y="1503.0"/> </glyph> <glyph class="state variable" id="_e992e5cb-1025-4895-a500-2fe20f21dd99"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="16430.88" y="1503.0"/> </glyph> <glyph class="state variable" id="_0fce6900-a745-4852-a891-11251e7a97a8"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="16431.5" y="1463.2147"/> </glyph> <glyph class="state variable" id="_eda87398-0e9f-44e6-b749-51db448f25ce"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="16391.531" y="1463.0"/> </glyph> <glyph class="state variable" id="_a75897c2-4a2b-4181-94ac-38bb15c93731"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="16351.992" y="1463.0"/> </glyph> <glyph class="state variable" id="_d8f7896c-90c6-41d9-a0c0-3b5a00361481"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="16351.5" y="1502.7223"/> </glyph> <glyph class="state variable" id="_323b2042-2f72-4395-9dd8-fa570669cd95"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="16429.0" y="1463.2147"/> </glyph> <glyph class="state variable" id="_9ff1dfdb-b252-4262-ac22-2fcbacc51bc7"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="16429.0" y="1463.2147"/> </glyph> <glyph class="state variable" id="_1227fbaa-01f4-4049-989b-e2f77175e8e9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16359.0" y="1483.0"/> </glyph> <glyph class="state variable" id="_33f46cf5-97b9-4bd9-9210-d31047430eeb"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="16349.492" y="1463.0"/> </glyph> <glyph class="state variable" id="_f9d40b4b-2438-4dea-94a7-5c6d0bb0acaa"> <state value="P" variable="Y654"/> <bbox w="35.0" h="10.0" x="16426.5" y="1463.2147"/> </glyph> <glyph class="state variable" id="_a062bf24-f417-4eb9-b896-f3332ada583e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16359.0" y="1474.7157"/> </glyph> <glyph class="state variable" id="_06baefe3-9120-4b80-a57f-f48152b88af2"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="16429.0" y="1463.2147"/> </glyph> <glyph class="state variable" id="_f72197e6-cbf5-4fbd-9122-c92f013b3670"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16359.0" y="1483.0"/> </glyph> <glyph class="state variable" id="_9a51028b-cb01-459a-a9e5-c5f51fdbc128"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="16428.38" y="1503.0"/> </glyph> <glyph class="state variable" id="_cfa6328a-1e16-4179-b4b6-617c1a9ac1fb"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="16429.0" y="1463.2147"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s159_wca1_wca2_sa113"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transforming growth factor beta 1 HUGO:TGFB1 HGNC:11766 ENTREZ:7040 UNIPROT:P01137 GENECARDS:TGFB1 REACTOME:65937 KEGG:7040 ATLASONC:GC_TGFB1 WIKI:TGFB1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:emtcellmotility / MODULE:ECM MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TGFB1"/> <bbox w="52.0" h="29.0" x="16339.0" y="1505.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s160_wca1_wca2_sa114"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transforming growth factor beta receptor 1 HUGO:TGFBR1 HGNC:11772 ENTREZ:7046 UNIPROT:P36897 GENECARDS:TGFBR1 REACTOME:65969 KEGG:7046 ATLASONC:GC_TGFBR1 WIKI:TGFBR1 transforming growth factor beta receptor 2 HUGO:TGFBR2 HGNC:11773 ENTREZ:7048 UNIPROT:P37173 GENECARDS:TGFBR2 REACTOME:65971 KEGG:7048 ATLASONC:GC_TGFBR2 WIKI:TGFBR2 transforming growth factor beta receptor 3 HUGO:TGFBR3 HGNC:11774 ENTREZ:7049 UNIPROT:Q03167 GENECARDS:TGFBR3 KEGG:7049 ATLASONC:TGFBR3ID42541ch1p33 WIKI:TGFBR3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TGFBR*"/> <bbox w="80.0" h="50.0" x="16326.0" y="1529.0"/> <glyph class="unit of information" id="_2fc7decb-102d-4f66-aa38-af7c0ed2f6db"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="16343.5" y="1524.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s161_wca1_wca2_csa19" compartmentRef="wca1_wca2_c2_wca1_wca2_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:E-Cadherin*:ITGA3:TGFB1:TGFBR*:p120* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re46:(MAP:survival) PMID:22203675 References_end</body> </html> </notes> <label text="E-Cadherin*:ITGA3:TGFB1:TGFBR*:p120*"/> <bbox w="202.0" h="249.0" x="16561.0" y="1368.1667"/> <glyph class="macromolecule" id="wca1_wca2_s162_wca1_wca2_sa115"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: integrin alpha 3 (antigen CD49C alpha 3 subunit of VLA-3 receptor) "antigen identified by monoclonal antibody J143" MSK18 HUGO:ITGA3 HGNC:6139 ENTREZ:3675 UNIPROT:P26006 GENECARDS:ITGA3 REACTOME:57565 KEGG:3675 ATLASONC:GC_ITGA3 WIKI:ITGA3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_MATRIX_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ITGA3"/> <bbox w="80.0" h="40.0" x="16643.0" y="1380.1667"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s163_wca1_wca2_sa116"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="123.0" h="41.0" x="16583.0" y="1426.1667"/> <glyph class="state variable" id="_e43d6e6e-f346-448f-b6d6-ae120ad8037b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16701.0" y="1421.1667"/> </glyph> <glyph class="state variable" id="_f2e5e93d-6856-4e97-9c37-026a3300e2c0"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="16569.96" y="1421.1667"/> </glyph> <glyph class="state variable" id="_bf3bff18-3a3a-4c80-aea2-cd60cff15d36"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="16691.0" y="1421.3868"/> </glyph> <glyph class="state variable" id="_2331372a-f8c2-442b-b25b-88f1432d18c3"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="16686.52" y="1462.1667"/> </glyph> <glyph class="state variable" id="_c8c44eb4-a989-4e8e-9323-c940ae44791d"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="16568.37" y="1462.1667"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s164_wca1_wca2_sa117"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="16579.0" y="1474.1667"/> <glyph class="state variable" id="_e1a084a3-265e-44aa-a01f-71a2fd0c2b9d"> <state value="" variable="S268"/> <bbox w="30.0" h="10.0" x="16564.492" y="1469.1667"/> </glyph> <glyph class="state variable" id="_e90486bd-f9f8-458f-a9ae-39b0195c4c2a"> <state value="" variable="S269"/> <bbox w="30.0" h="10.0" x="16604.031" y="1469.1667"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s165_wca1_wca2_sa119"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transforming growth factor beta 1 HUGO:TGFB1 HGNC:11766 ENTREZ:7040 UNIPROT:P01137 GENECARDS:TGFB1 REACTOME:65937 KEGG:7040 ATLASONC:GC_TGFB1 WIKI:TGFB1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:emtcellmotility / MODULE:ECM MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TGFB1"/> <bbox w="52.0" h="29.0" x="16636.0" y="1506.1667"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s166_wca1_wca2_sa120"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transforming growth factor beta receptor 1 HUGO:TGFBR1 HGNC:11772 ENTREZ:7046 UNIPROT:P36897 GENECARDS:TGFBR1 REACTOME:65969 KEGG:7046 ATLASONC:GC_TGFBR1 WIKI:TGFBR1 transforming growth factor beta receptor 2 HUGO:TGFBR2 HGNC:11773 ENTREZ:7048 UNIPROT:P37173 GENECARDS:TGFBR2 REACTOME:65971 KEGG:7048 ATLASONC:GC_TGFBR2 WIKI:TGFBR2 transforming growth factor beta receptor 3 HUGO:TGFBR3 HGNC:11774 ENTREZ:7049 UNIPROT:Q03167 GENECARDS:TGFBR3 KEGG:7049 ATLASONC:TGFBR3ID42541ch1p33 WIKI:TGFBR3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TGFBR*"/> <bbox w="80.0" h="50.0" x="16623.0" y="1530.1667"/> <glyph class="unit of information" id="_a65e8493-80d2-42b2-888d-bd84d0c22ac5"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="16640.5" y="1525.1667"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s169_wca1_wca2_csa20" compartmentRef="wca1_wca2_c3_wca1_wca2_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:SMAD2:_beta_-Catenin* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re47:(MAP:survival) PMID:19104148 s_wca2_re43(MAP:survival): Y654-phosphorylated isoform is able to induce canonical TCF/LEF transcription PMID:22203675 s_wca2_re44(MAP:survival): Only Y654-phosphorylated isoform of beta-catenin was able to indcue EMT References_end</body> </html> </notes> <label text="SMAD2:β-Catenin*"/> <bbox w="100.0" h="120.0" x="16118.0" y="1830.0"/> <glyph class="macromolecule" id="wca1_wca2_s171_wca1_wca2_sa122"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="16129.0" y="1844.25"/> <glyph class="state variable" id="_69919c98-6481-4a24-9715-699b1de72869"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="16156.404" y="1879.25"/> </glyph> <glyph class="state variable" id="_e8285c1a-2e05-4dce-a07f-d6c1f8fc9514"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="16195.882" y="1879.25"/> </glyph> <glyph class="state variable" id="_9835c5a5-cd60-403d-a65b-544f0bcd1c02"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="16196.5" y="1839.4647"/> </glyph> <glyph class="state variable" id="_5aa8687c-9951-4037-aa15-765368cb73fe"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="16156.532" y="1839.25"/> </glyph> <glyph class="state variable" id="_0c072718-b25f-46b1-9acb-a0e3123f9908"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="16116.992" y="1839.25"/> </glyph> <glyph class="state variable" id="_5e1befe8-ac8e-44c1-9fc6-48af80f1ca08"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="16116.5" y="1878.9723"/> </glyph> <glyph class="state variable" id="_05728b5a-66c1-40cd-b3ef-31875b95353f"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="16194.0" y="1839.4647"/> </glyph> <glyph class="state variable" id="_c378e5dc-e9bf-49f0-bc75-6136192c7452"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="16194.0" y="1839.4647"/> </glyph> <glyph class="state variable" id="_989ecdcb-27bc-49c8-b785-b7d7f383733b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16124.0" y="1859.25"/> </glyph> <glyph class="state variable" id="_8011da3c-f631-444c-81fa-26992d0bfde0"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="16114.492" y="1839.25"/> </glyph> <glyph class="state variable" id="_99980216-db59-4fdd-a8fe-7b190999345a"> <state value="P" variable="Y654"/> <bbox w="35.0" h="10.0" x="16191.5" y="1839.4647"/> </glyph> <glyph class="state variable" id="_0276839e-ba97-43a0-be78-7ae414efef1f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16124.0" y="1850.9657"/> </glyph> <glyph class="state variable" id="_d58cb6de-b67c-41d1-bc22-e7a004030c1b"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="16194.0" y="1839.4647"/> </glyph> <glyph class="state variable" id="_45e1619a-6310-4b61-b254-15f32f2441d7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16124.0" y="1859.25"/> </glyph> <glyph class="state variable" id="_19867803-0323-4f03-8050-15bae7705f62"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="16193.382" y="1879.25"/> </glyph> <glyph class="state variable" id="_bdbf25e6-a3d5-4a38-b063-b0a23053a333"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="16194.0" y="1839.4647"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s170_wca1_wca2_sa123"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: SMAD family member 2 "MAD mothers against decapentaplegic homolog 2 (Drosophila)" MADH2 "SMAD mothers against DPP homolog 2 (Drosophila)" HUGO:SMAD2 HGNC:6768 ENTREZ:4087 UNIPROT:Q15796 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TGF-?? exerts its biological effects by binding to a cell surface receptor complex composed of type I (TbRI) and type II (TbRII) receptor serine/threonine kinases. Upon ligand binding TbRII phosphorylates and activates TbRI which subsequently phosphorylates the cytoplasmic Smad2 and Smad3 proteins. Phosphorylated Smad proteins form stable complexes with a common partner Smad4. The activated Smad2/4 and Smad3/4 complexes translocate into the nucleus where the Smad oligomers induce transcriptional activation (or inhibition) of specific target genes. PMID:21614932 References_end Identifiers_begin: SMAD family member 2 "MAD mothers against decapentaplegic homolog 2 (Drosophila)" MADH2 "SMAD mothers against DPP homolog 2 (Drosophila)" HUGO:SMAD2 HGNC:6768 ENTREZ:4087 UNIPROT:Q15796 GENECARDS:SMAD2 REACTOME:405890 KEGG:4087 ATLASONC:SMAD2ID370 WIKI:SMAD2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: TGF-?? exerts its biological effects by binding to a cell surface receptor complex composed of type I (TbRI) and type II (TbRII) receptor serine/threonine kinases. Upon ligand binding TbRII phosphorylates and activates TbRI which subsequently phosphorylates the cytoplasmic Smad2 and Smad3 proteins. Phosphorylated Smad proteins form stable complexes with a common partner Smad4. The activated Smad2/4 and Smad3/4 complexes translocate into the nucleus where the Smad oligomers induce transcriptional activation (or inhibition) of specific target genes. PMID:21614932 References_end</body> </html> </notes> <label text="SMAD2"/> <bbox w="80.0" h="40.0" x="16129.0" y="1886.75"/> <glyph class="state variable" id="_7fc71a8f-e87a-4145-a261-54b1f33bb7aa"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="16201.5" y="1881.75"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s214_wca1_wca2_csa22" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK1*:LRP6:TMEM198 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: TMEM198 can aggegrate multiple LRP6 molecules in signalosome-like structures and recrute CK1 family members PMID:21536646 References_end</body> </html> </notes> <label text="Signalosome-like"/> <bbox w="106.0" h="278.0" x="15479.0" y="2035.0"/> <glyph class="macromolecule" id="wca1_wca2_s220_wca1_wca2_sa145"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transmembrane protein 198 HUGO:TMEM198 HGNC:33704 ENTREZ:130612 UNIPROT:Q66K66 GENECARDS:TMEM198 KEGG:130612 WIKI:TMEM198 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TMEM198"/> <bbox w="80.0" h="40.0" x="15494.5" y="2049.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s219_wca1_wca2_sa146"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LRP6"/> <bbox w="80.0" h="50.0" x="15494.5" y="2091.0"/> <glyph class="state variable" id="_983c1ac9-c953-401f-8614-0052748db245"> <state value="" variable="T1572"/> <bbox w="35.0" h="10.0" x="15477.0" y="2110.9602"/> </glyph> <glyph class="state variable" id="_325f2e52-c2fb-40c4-adf9-999a5ed489ad"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="15517.032" y="2086.0"/> </glyph> <glyph class="state variable" id="_57cd250f-978c-41d1-af4a-9aa101eed7b1"> <state value="" variable="S1544"/> <bbox w="35.0" h="10.0" x="15557.0" y="2086.2686"/> </glyph> <glyph class="state variable" id="_f67f097c-9773-4582-9376-471fa8c12cc8"> <state value="" variable="T1548"/> <bbox w="35.0" h="10.0" x="15557.0" y="2124.4373"/> </glyph> <glyph class="state variable" id="_19c83570-a21e-4a5e-a710-0402534447d8"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="15557.0" y="2086.2686"/> </glyph> <glyph class="state variable" id="_d6fa5f57-46e8-4e49-b30a-aa10677f903e"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="15477.492" y="2086.0"/> </glyph> <glyph class="unit of information" id="_328b5902-0d72-4b89-beb6-37e0f1413b11"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="15512.0" y="2086.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s219_wca1_wca2_sa147"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LRP6"/> <bbox w="80.0" h="50.0" x="15494.5" y="2184.0"/> <glyph class="state variable" id="_cc1bd56b-6152-4f6d-9249-4a06d3ec62fe"> <state value="" variable="T1572"/> <bbox w="35.0" h="10.0" x="15477.0" y="2203.9602"/> </glyph> <glyph class="state variable" id="_9e4d8c69-fc0d-48f0-887a-be7456ede300"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="15517.032" y="2179.0"/> </glyph> <glyph class="state variable" id="_13796975-dd80-4dac-a479-ce5a07f634fd"> <state value="" variable="S1544"/> <bbox w="35.0" h="10.0" x="15557.0" y="2179.2686"/> </glyph> <glyph class="state variable" id="_824de6ab-b56e-43a9-81fa-669b71aca102"> <state value="" variable="T1548"/> <bbox w="35.0" h="10.0" x="15557.0" y="2217.4373"/> </glyph> <glyph class="state variable" id="_093a952f-1b40-46bd-8d34-8af1592727f5"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="15557.0" y="2179.2686"/> </glyph> <glyph class="state variable" id="_1207c5c1-3f47-437f-9e6f-32a537ea22c1"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="15477.492" y="2179.0"/> </glyph> <glyph class="unit of information" id="_570c9020-859c-4825-8d9d-80d233a2c5c1"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="15512.0" y="2179.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s220_wca1_wca2_sa148"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transmembrane protein 198 HUGO:TMEM198 HGNC:33704 ENTREZ:130612 UNIPROT:Q66K66 GENECARDS:TMEM198 KEGG:130612 WIKI:TMEM198 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TMEM198"/> <bbox w="80.0" h="40.0" x="15494.5" y="2142.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s226_wca1_wca2_sa150"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end</body> </html> Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end</body> </html> Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end</body> </html> </notes> <label text="CK1*"/> <bbox w="80.0" h="40.0" x="15492.5" y="2234.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s235_wca1_wca2_csa24" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DVL2:RIPK4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re58(MAP:survival): DVL and RIPK4 form constitutively a complex PMID:23371553 References_end</body> </html> </notes> <label text="DVL2:RIPK4"/> <bbox w="100.0" h="120.0" x="17321.0" y="1443.0"/> <glyph class="macromolecule" id="wca1_wca2_s237_wca1_wca2_sa156"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: receptor-interacting serine-threonine kinase 4 ANKRD3 "ankyrin repeat domain 3" HUGO:RIPK4 HGNC:496 ENTREZ:54101 UNIPROT:P57078 GENECARDS:RIPK4 KEGG:54101 ATLASONC:GC_RIPK4 WIKI:RIPK4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RIPK4"/> <bbox w="80.0" h="40.0" x="17330.0" y="1499.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s236_wca1_wca2_sa157"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: dishevelled dsh homolog 2 (Drosophila) "dishevelled 2 (homologous to Drosophila dsh)" HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:16273260 References_end</body> </html> </notes> <label text="DVL2"/> <bbox w="80.0" h="40.0" x="17330.0" y="1454.0"/> <glyph class="state variable" id="_710df5fd-36e5-42b4-b03c-883bc616c038"> <state value="" variable="S480"/> <bbox w="30.0" h="10.0" x="17315.492" y="1449.0"/> </glyph> <glyph class="state variable" id="_3f0c6e32-4041-4fc9-90a9-a976f90bf5a1"> <state value="" variable="S298"/> <bbox w="30.0" h="10.0" x="17315.0" y="1488.7223"/> </glyph> <glyph class="state variable" id="_50063dfc-6a4d-46a4-82ad-a643f58a4f56"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="17405.0" y="1449.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s238_wca1_wca2_csa25" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DVL2:RIPK4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re59:(MAP:survival) PMID:23371553 s_wca2_re60(MAP:survival): Without RIPK4 upon wnt3 stimulation 25% of HeLa cells show DVL2 in puncta. Co-transfection of RIPK4 increases this number to more than 75% PMID:23371553 References_end</body> </html> </notes> <label text="DVL2:RIPK4"/> <bbox w="100.0" h="120.0" x="17489.0" y="1444.0"/> <glyph class="macromolecule" id="wca1_wca2_s239_wca1_wca2_sa160"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: receptor-interacting serine-threonine kinase 4 ANKRD3 "ankyrin repeat domain 3" HUGO:RIPK4 HGNC:496 ENTREZ:54101 UNIPROT:P57078 GENECARDS:RIPK4 KEGG:54101 ATLASONC:GC_RIPK4 WIKI:RIPK4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RIPK4"/> <bbox w="80.0" h="40.0" x="17498.0" y="1500.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s240_wca1_wca2_sa161"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: dishevelled dsh homolog 2 (Drosophila) "dishevelled 2 (homologous to Drosophila dsh)" HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:16273260 References_end</body> </html> </notes> <label text="DVL2"/> <bbox w="80.0" h="40.0" x="17498.0" y="1455.0"/> <glyph class="state variable" id="_1e007272-f862-4cba-93b5-99165a382b90"> <state value="P" variable="S480"/> <bbox w="35.0" h="10.0" x="17480.992" y="1450.0"/> </glyph> <glyph class="state variable" id="_0c121964-4d50-4db1-b2e2-bbd3c4bf8197"> <state value="P" variable="S298"/> <bbox w="35.0" h="10.0" x="17480.5" y="1489.7223"/> </glyph> <glyph class="state variable" id="_4b6d96f6-cf1c-498d-9813-734162436966"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="17573.0" y="1450.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s241_wca1_wca2_csa26" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DVL2:LRP6:RIPK4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re60(MAP:survival): Without RIPK4 upon wnt3 stimulation 25% of HeLa cells show DVL2 in puncta. Co-transfection of RIPK4 increases this number to more than 75% PMID:23371553 s_wca2_re61:(MAP:survival) continue with dvl puncta formation References_end</body> </html> </notes> <label text="DVL2:LRP6:RIPK4"/> <bbox w="99.0" h="173.0" x="17613.0" y="1221.0"/> <glyph class="macromolecule" id="wca1_wca2_s242_wca1_wca2_sa163"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: receptor-interacting serine-threonine kinase 4 ANKRD3 "ankyrin repeat domain 3" HUGO:RIPK4 HGNC:496 ENTREZ:54101 UNIPROT:P57078 GENECARDS:RIPK4 KEGG:54101 ATLASONC:GC_RIPK4 WIKI:RIPK4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RIPK4"/> <bbox w="80.0" h="40.0" x="17622.0" y="1277.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s243_wca1_wca2_sa164"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: dishevelled dsh homolog 2 (Drosophila) "dishevelled 2 (homologous to Drosophila dsh)" HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:16273260 References_end</body> </html> </notes> <label text="DVL2"/> <bbox w="80.0" h="40.0" x="17622.0" y="1232.0"/> <glyph class="state variable" id="_5ec8441d-fdec-4a21-9036-0ccc60ea86ab"> <state value="P" variable="S480"/> <bbox w="35.0" h="10.0" x="17604.992" y="1227.0"/> </glyph> <glyph class="state variable" id="_beda577c-edbb-482b-9fb9-628daede49e9"> <state value="P" variable="S298"/> <bbox w="35.0" h="10.0" x="17604.5" y="1266.7223"/> </glyph> <glyph class="state variable" id="_dc24d88e-49d1-4548-bc51-dbf8db1564ae"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="17697.0" y="1227.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s244_wca1_wca2_sa165"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LRP6"/> <bbox w="80.0" h="50.0" x="17621.0" y="1321.0"/> <glyph class="state variable" id="_29b831b2-c4a9-4cb2-9269-210fed65d594"> <state value="" variable="T1572"/> <bbox w="35.0" h="10.0" x="17603.5" y="1340.9602"/> </glyph> <glyph class="state variable" id="_6f977707-e2ea-4529-aa83-bd3bdf97d57e"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="17643.531" y="1316.0"/> </glyph> <glyph class="state variable" id="_e0ccb0ac-d64c-4efc-9ac5-743a264322c3"> <state value="" variable="S1544"/> <bbox w="35.0" h="10.0" x="17683.5" y="1316.2684"/> </glyph> <glyph class="state variable" id="_08800f9d-0356-4e86-8810-028cd201de31"> <state value="" variable="T1548"/> <bbox w="35.0" h="10.0" x="17683.5" y="1354.4371"/> </glyph> <glyph class="state variable" id="_3b2708de-9487-482b-9c05-0488b7a83387"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="17683.5" y="1316.2684"/> </glyph> <glyph class="state variable" id="_c9848805-d907-4487-8b0b-9cdd93174715"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="17603.992" y="1316.0"/> </glyph> <glyph class="unit of information" id="_2acd5292-7fa9-4b81-aaee-a6b3eae5ba08"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="17638.5" y="1316.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s253_wca1_wca2_csa27" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AXIN*:CK1_alpha_*:GSK3* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="AXIN*:CK1α*:GSK3*"/> <bbox w="211.0" h="121.0" x="16456.0" y="1196.0"/> <glyph class="macromolecule" id="wca1_wca2_s254_wca1_wca2_sa173"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="16471.0" y="1210.0"/> <glyph class="state variable" id="_6f83fc5d-648a-4f08-85e3-90158b632192"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="16458.992" y="1205.0"/> </glyph> <glyph class="state variable" id="_42805f8c-505b-482f-b4b8-5f766b0f7777"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="16498.531" y="1205.0"/> </glyph> <glyph class="state variable" id="_bf3fba14-5ee4-47a2-939f-db5cb84ff1e6"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="16536.0" y="1205.2147"/> </glyph> <glyph class="state variable" id="_19dc4cc4-ce83-4a1b-a0f1-74ac2dfa9b31"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="16535.38" y="1245.0"/> </glyph> <glyph class="state variable" id="_9757b434-b0a0-4f48-80b3-1c7474daf116"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="16495.904" y="1245.0"/> </glyph> <glyph class="state variable" id="_24030094-92b5-4db6-9124-271b8a2a1c1a"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="16456.0" y="1244.7223"/> </glyph> <glyph class="state variable" id="_c6b078e0-0198-46b1-bf9c-e59739e1c59b"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="16498.404" y="1245.0"/> </glyph> <glyph class="state variable" id="_512f0097-2605-4d4c-a624-6ccac0cf7bd6"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="16537.88" y="1245.0"/> </glyph> <glyph class="state variable" id="_fe6fcf68-1c96-477b-8840-fe1b58fcb100"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="16543.5" y="1205.2147"/> </glyph> <glyph class="state variable" id="_d45b8a70-eff6-4f65-bfcb-43c1f5b2d034"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="16458.5" y="1244.7223"/> </glyph> <glyph class="state variable" id="_6dc26891-19af-474a-9cde-bcaa76397922"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="16463.992" y="1205.0"/> </glyph> <glyph class="state variable" id="_86c87744-33cb-432d-ab22-c3ac67afa924"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16466.0" y="1205.0"/> </glyph> <glyph class="state variable" id="_6e900057-7ca1-4bac-adbc-9ad8f3111d21"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16546.0" y="1205.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s252_wca1_wca2_sa174"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="16556.0" y="1208.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s255_wca1_wca2_sa175"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="16559.0" y="1252.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s265_wca1_wca2_csa29" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:E-Cadherin*:ITGA9:_beta_-Catenin* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re67:(MAP:survival) PMID:22370635 References_end</body> </html> </notes> <label text="E-Cadherin*:ITGA9:β-Catenin*"/> <bbox w="229.0" h="135.0" x="15763.0" y="2453.0"/> <glyph class="macromolecule" id="wca1_wca2_s264_wca1_wca2_sa184"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: integrin alpha 9 HUGO:ITGA9 HGNC:6145 ENTREZ:3680 UNIPROT:Q13797 GENECARDS:ITGA9 REACTOME:57577 KEGG:3680 ATLASONC:GC_ITGA9 WIKI:ITGA9 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_MATRIX_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ITGA9"/> <bbox w="80.0" h="40.0" x="15802.0" y="2467.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s267_wca1_wca2_sa185"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="123.0" h="41.0" x="15805.75" y="2521.5"/> <glyph class="state variable" id="_1189b9c7-b2ec-4562-951b-a790a391d806"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15923.75" y="2516.5"/> </glyph> <glyph class="state variable" id="_0f0a6d18-93a3-4118-a66d-41e708fa575e"> <state value="P" variable="S849"/> <bbox w="35.0" h="10.0" x="15790.21" y="2516.5"/> </glyph> <glyph class="state variable" id="_23e73182-0534-4be3-b388-0a0560a809c7"> <state value="P" variable="S853"/> <bbox w="35.0" h="10.0" x="15911.25" y="2516.7202"/> </glyph> <glyph class="state variable" id="_24d922f7-5d15-48a3-baea-2fa231afcd7c"> <state value="P" variable="S855"/> <bbox w="35.0" h="10.0" x="15906.77" y="2557.5"/> </glyph> <glyph class="state variable" id="_23f27e30-e25a-4c5e-a030-58724237999b"> <state value="P" variable="S840"/> <bbox w="35.0" h="10.0" x="15788.619" y="2557.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s266_wca1_wca2_sa186"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="15888.0" y="2468.5"/> <glyph class="state variable" id="_6f64c730-a69e-437c-898c-47faa95309a5"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="15915.404" y="2503.5"/> </glyph> <glyph class="state variable" id="_d0af7414-e09b-49e4-95c7-c8718f153f29"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="15954.882" y="2503.5"/> </glyph> <glyph class="state variable" id="_d930282a-2ec2-4910-8532-a4c0d411b7f0"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="15955.5" y="2463.7148"/> </glyph> <glyph class="state variable" id="_afe1ddb7-d9dc-45c0-9ee9-c7b22756af2c"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="15915.532" y="2463.5"/> </glyph> <glyph class="state variable" id="_6f777c0d-a135-4ae3-9efa-2219c8f183f5"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="15875.992" y="2463.5"/> </glyph> <glyph class="state variable" id="_ba96d542-aab2-44e1-a672-efab5ec88851"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="15875.5" y="2503.2224"/> </glyph> <glyph class="state variable" id="_1a861088-b006-411d-9c0f-17f9cb8af222"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="15953.0" y="2463.7148"/> </glyph> <glyph class="state variable" id="_e1b6429e-07a0-4101-a9dd-6860540bd2d4"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="15953.0" y="2463.7148"/> </glyph> <glyph class="state variable" id="_0c214be3-bcac-42df-8228-384d626ec391"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15883.0" y="2483.5"/> </glyph> <glyph class="state variable" id="_2f5355a7-ce57-4b0f-91b7-c295c5498def"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="15873.492" y="2463.5"/> </glyph> <glyph class="state variable" id="_6d9ce0a8-e739-41d0-a8f5-dfe03fd5a5d9"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="15953.0" y="2463.7148"/> </glyph> <glyph class="state variable" id="_e1ab63b0-4ead-4336-a3f5-900fa69f0cb2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15883.0" y="2475.2158"/> </glyph> <glyph class="state variable" id="_f60c63e0-1f95-4c00-b916-1f6ac0b14224"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="15953.0" y="2463.7148"/> </glyph> <glyph class="state variable" id="_6600a995-2a73-4586-ab29-2451c96d9001"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15883.0" y="2483.5"/> </glyph> <glyph class="state variable" id="_d7298ce5-6bea-4c1a-b00f-af9b6e8b26d2"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="15952.382" y="2503.5"/> </glyph> <glyph class="state variable" id="_632ec5cd-b4e3-4839-b956-05b427c3e0fc"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="15953.0" y="2463.7148"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s269_wca1_wca2_csa30" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:E-Cadherin*:ITGA9:_beta_-Catenin* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re68:(MAP:survival) PMID:22370635 References_end</body> </html> </notes> <label text="E-Cadherin*:ITGA9:β-Catenin*"/> <bbox w="229.0" h="135.0" x="15764.0" y="2153.5"/> <glyph class="macromolecule" id="wca1_wca2_s274_wca1_wca2_sa187"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: integrin alpha 9 HUGO:ITGA9 HGNC:6145 ENTREZ:3680 UNIPROT:Q13797 GENECARDS:ITGA9 REACTOME:57577 KEGG:3680 ATLASONC:GC_ITGA9 WIKI:ITGA9 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_MATRIX_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ITGA9"/> <bbox w="80.0" h="40.0" x="15803.0" y="2168.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s275_wca1_wca2_sa188"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="123.0" h="41.0" x="15806.75" y="2222.0"/> <glyph class="state variable" id="_ebbb2a41-2604-400f-b4b1-9ca2c270c9fa"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15924.75" y="2217.0"/> </glyph> <glyph class="state variable" id="_0dd154e2-8154-49b2-aa7a-4a605c3ba2a1"> <state value="P" variable="S849"/> <bbox w="35.0" h="10.0" x="15791.21" y="2217.0"/> </glyph> <glyph class="state variable" id="_aa1b0731-4077-4296-bad8-aa06eaa0483e"> <state value="P" variable="S853"/> <bbox w="35.0" h="10.0" x="15912.25" y="2217.2202"/> </glyph> <glyph class="state variable" id="_83f9bea6-0fe2-46c0-b3ab-5f656dc571dd"> <state value="P" variable="S855"/> <bbox w="35.0" h="10.0" x="15907.77" y="2258.0"/> </glyph> <glyph class="state variable" id="_e8b5d76e-7db5-4ef7-bc10-5b6eec00bb8f"> <state value="P" variable="S840"/> <bbox w="35.0" h="10.0" x="15789.619" y="2258.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s276_wca1_wca2_sa189"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="15889.0" y="2169.0"/> <glyph class="state variable" id="_2a80aa99-f8a3-4f47-9ae5-8ddde38958e9"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="15916.404" y="2204.0"/> </glyph> <glyph class="state variable" id="_062d327d-3d19-465b-bc24-295a87c14d9d"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="15955.882" y="2204.0"/> </glyph> <glyph class="state variable" id="_d5c7f498-5ea0-4f74-bc07-f3771c04d23d"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="15956.5" y="2164.2148"/> </glyph> <glyph class="state variable" id="_1fdb9d53-5412-4680-948b-43ef4b8aa453"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="15916.532" y="2164.0"/> </glyph> <glyph class="state variable" id="_9c78b4c3-3667-468a-a9f1-c89e1829ae0e"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="15876.992" y="2164.0"/> </glyph> <glyph class="state variable" id="_38e36319-9c61-4457-96f7-e4451320987d"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="15876.5" y="2203.7224"/> </glyph> <glyph class="state variable" id="_260f8586-7ffd-41bc-a188-f62f32e0721c"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="15954.0" y="2164.2148"/> </glyph> <glyph class="state variable" id="_2d769ec5-0798-405e-8f7f-1a9230a3b787"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="15954.0" y="2164.2148"/> </glyph> <glyph class="state variable" id="_e04b3edd-ab0d-4f07-8bb6-9a7bac4f5861"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15884.0" y="2184.0"/> </glyph> <glyph class="state variable" id="_7006bed6-8a66-45a2-8041-c18e5a2fb96a"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="15874.492" y="2164.0"/> </glyph> <glyph class="state variable" id="_b88bad01-6498-4e7d-b1a5-f93a501e1bff"> <state value="P" variable="Y654"/> <bbox w="35.0" h="10.0" x="15951.5" y="2164.2148"/> </glyph> <glyph class="state variable" id="_37c1f15b-4376-4a2d-9922-5dfc27f5c030"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15884.0" y="2175.7158"/> </glyph> <glyph class="state variable" id="_ef1e44e4-00ce-4c63-b043-c29af7f80ca2"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="15954.0" y="2164.2148"/> </glyph> <glyph class="state variable" id="_3d22f972-1af9-45a2-adca-ada47bf5464e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15884.0" y="2184.0"/> </glyph> <glyph class="state variable" id="_e64df736-36d3-483d-8307-eda9ec0beb5a"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="15953.382" y="2204.0"/> </glyph> <glyph class="state variable" id="_65e12566-fa0f-43a5-ac46-92737845fa1d"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="15954.0" y="2164.2148"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s280_wca1_wca2_csa31" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:E-Cadherin*:ITGA9 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re69:(MAP:survival) PMID:22370635 References_end</body> </html> </notes> <label text="E-Cadherin*:ITGA9"/> <bbox w="229.0" h="135.0" x="15942.0" y="1988.5"/> <glyph class="macromolecule" id="wca1_wca2_s278_wca1_wca2_sa190"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: integrin alpha 9 HUGO:ITGA9 HGNC:6145 ENTREZ:3680 UNIPROT:Q13797 GENECARDS:ITGA9 REACTOME:57577 KEGG:3680 ATLASONC:GC_ITGA9 WIKI:ITGA9 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_MATRIX_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ITGA9"/> <bbox w="80.0" h="40.0" x="15981.0" y="2003.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s279_wca1_wca2_sa191"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="123.0" h="41.0" x="15984.75" y="2057.0"/> <glyph class="state variable" id="_83d0d9b9-f729-47e8-bace-33c4fbfbac73"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16102.75" y="2052.0"/> </glyph> <glyph class="state variable" id="_7e21a0d3-7fa4-4c89-b415-1005ad52a37e"> <state value="P" variable="S849"/> <bbox w="35.0" h="10.0" x="15969.21" y="2052.0"/> </glyph> <glyph class="state variable" id="_9cec0ca6-578f-45ca-94ec-6093647bd0cb"> <state value="P" variable="S853"/> <bbox w="35.0" h="10.0" x="16090.25" y="2052.2202"/> </glyph> <glyph class="state variable" id="_aaf5558a-f1a2-43dd-969a-b84447325ec7"> <state value="P" variable="S855"/> <bbox w="35.0" h="10.0" x="16085.77" y="2093.0"/> </glyph> <glyph class="state variable" id="_46a04b34-d1a2-45f3-8ee5-efd830437b93"> <state value="P" variable="S840"/> <bbox w="35.0" h="10.0" x="15967.619" y="2093.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s284_wca1_wca2_csa32" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CRIPTO-1*:LRP5_6* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re70:(MAP:survival) PMID:23022962 s_wca2_re72(MAP:survival): Upon WNT3a CRIPTO-1 binds to LRP5/6 this binding is competing with DKK binding PMID:23022962 References_end</body> </html> </notes> <label text="CRIPTO-1*:LRP5_6*"/> <bbox w="100.0" h="120.0" x="17619.0" y="1557.0"/> <glyph class="macromolecule" id="wca1_wca2_s282_wca1_wca2_sa193"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="17631.5" y="1564.0"/> <glyph class="state variable" id="_852f830f-8b1d-436b-8acd-41bf0340813d"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="17614.0" y="1583.9602"/> </glyph> <glyph class="state variable" id="_4f24cabb-ebd8-4492-9977-d9f6d14a0a2d"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="17654.031" y="1559.0"/> </glyph> <glyph class="state variable" id="_ebf1e2fb-24c9-44a2-8ede-aa5fac3fea76"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="17694.0" y="1559.2684"/> </glyph> <glyph class="state variable" id="_6adacba8-e0ea-46d2-8fa2-865ee6fedf7a"> <state value="" variable="S1496"/> <bbox w="35.0" h="10.0" x="17693.38" y="1609.0"/> </glyph> <glyph class="state variable" id="_c5255ffc-2045-483f-8307-122152677358"> <state value="" variable="T1530"/> <bbox w="35.0" h="10.0" x="17653.104" y="1609.0"/> </glyph> <glyph class="state variable" id="_5b045fb5-f4e2-4e1f-b690-98f0e3025cb1"> <state value="" variable="S1533"/> <bbox w="35.0" h="10.0" x="17614.24" y="1609.0"/> </glyph> <glyph class="unit of information" id="_2ab7a318-f753-4312-88c9-c7e9df242d43"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="17649.0" y="1559.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s283_wca1_wca2_sa194"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: teratocarcinoma-derived growth factor 1 HUGO:TDGF1 HGNC:11701 ENTREZ:6997 UNIPROT:P13385 GENECARDS:TDGF1 REACTOME:52798 KEGG:6997 ATLASONC:GC_TDGF1 WIKI:TDGF1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CRIPTO-1*"/> <bbox w="80.0" h="40.0" x="17631.5" y="1612.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s304_wca1_wca2_csa33" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CRIPTO-1*:E-Cadherin*:FZD*:GTP:G_alpha_o*:G_beta_*:G_gamma_*:LRP5_6*:WNT* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re72(MAP:survival): Upon WNT3a CRIPTO-1 binds to LRP5/6 this binding is competing with DKK binding PMID:23022962 s_wca2_re71(MAP:survival): Binding of CRIPTO-1 to LRP5/6 enhances Topflash activity References_end</body> </html> </notes> <label text="CRIPTO-1*:E-Cadherin*:FZD*:GTP:Gαo*:Gβ*:Gγ*:LRP5_6*:WNT*"/> <bbox w="246.0" h="169.0" x="17486.0" y="1708.0"/> <glyph class="macromolecule" id="wca1_wca2_s296_wca1_wca2_sa195"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end Identifiers_begin: low density lipoprotein receptor-related protein 5 HUGO:LRP5 HGNC:6697 ENTREZ:4041 UNIPROT:O75197 GENECARDS:LRP5 KEGG:4041 ATLASONC:LRP5ID44282ch11q13 WIKI:LRP5 low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 PMID:16443747 WNT3a requires LRP6 to activate wnt PMID:22433869 PMID:19072724 References_end</body> </html> </notes> <label text="LRP5_6*"/> <bbox w="80.0" h="50.0" x="17572.0" y="1778.0"/> <glyph class="state variable" id="_de7b3a93-8245-4603-a965-914da4ec8427"> <state value="" variable="T1479"/> <bbox w="35.0" h="10.0" x="17554.5" y="1797.9602"/> </glyph> <glyph class="state variable" id="_28d57206-9b6f-4dba-b682-8aeb966cec00"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="17594.531" y="1773.0"/> </glyph> <glyph class="state variable" id="_6fe1bb1f-ecdc-424c-8b9b-8f5739da86ff"> <state value="" variable="T1493"/> <bbox w="35.0" h="10.0" x="17634.5" y="1773.2684"/> </glyph> <glyph class="state variable" id="_9f2ffde6-7b73-414e-b14e-2022e5775579"> <state value="" variable="S1496"/> <bbox w="35.0" h="10.0" x="17633.88" y="1823.0"/> </glyph> <glyph class="state variable" id="_f25ffbf6-90e0-41b5-b120-92d3e4369c2c"> <state value="" variable="T1530"/> <bbox w="35.0" h="10.0" x="17593.604" y="1823.0"/> </glyph> <glyph class="state variable" id="_32a99a1e-7bce-4f9f-a108-130d43b2a595"> <state value="" variable="S1533"/> <bbox w="35.0" h="10.0" x="17554.74" y="1823.0"/> </glyph> <glyph class="unit of information" id="_24be80ae-42e7-4757-88cb-97e2e715ebb8"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="17589.5" y="1773.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s297_wca1_wca2_sa196"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="17572.0" y="1738.0"/> <glyph class="unit of information" id="_5d3d5de8-b289-4d7b-8a42-bbf242fb5c4b"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="17589.5" y="1733.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s298_wca1_wca2_sa197"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="30.0" h="20.0" x="17597.0" y="1728.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s299_wca1_wca2_sa198"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="53.0" h="123.0" x="17655.5" y="1716.5"/> <glyph class="state variable" id="_006b03b7-33e9-424a-adf8-d7132a419ec9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="17703.5" y="1711.5"/> </glyph> <glyph class="state variable" id="_f56a6cee-567d-4802-acf3-fd96a8f8ecc1"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="17641.344" y="1711.5"/> </glyph> <glyph class="state variable" id="_4039955a-9081-4a85-905c-fec682e21d68"> <state value="" variable="S853"/> <bbox w="30.0" h="10.0" x="17693.5" y="1712.1604"/> </glyph> <glyph class="state variable" id="_ef1ae2da-24ee-4ef8-9315-55c141314e6a"> <state value="" variable="S855"/> <bbox w="30.0" h="10.0" x="17691.568" y="1834.5"/> </glyph> <glyph class="state variable" id="_b026132e-5547-488d-b94a-4f999afa3fc4"> <state value="" variable="S840"/> <bbox w="30.0" h="10.0" x="17640.658" y="1834.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s300_wca1_wca2_sa199"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: guanine nucleotide binding protein (G protein) alpha 11 (Gq class) HUGO:GNA11 HGNC:4379 ENTREZ:2767 UNIPROT:P29992 GENECARDS:GNA11 REACTOME:55354 KEGG:2767 ATLASONC:GNA11ID43272ch19p13 WIKI:GNA11 guanine nucleotide binding protein (G protein) alpha 12 HUGO:GNA12 HGNC:4380 ENTREZ:2768 UNIPROT:Q03113 GENECARDS:GNA12 REACTOME:55356 KEGG:2768 ATLASONC:GC_GNA12 WIKI:GNA12 guanine nucleotide binding protein (G protein) alpha 13 HUGO:GNA13 HGNC:4381 ENTREZ:10672 UNIPROT:Q14344 GENECARDS:GNA13 REACTOME:55358 KEGG:10672 ATLASONC:GC_GNA13 WIKI:GNA13 guanine nucleotide binding protein (G protein) alpha 14 HUGO:GNA14 HGNC:4382 ENTREZ:9630 UNIPROT:O95837 GENECARDS:GNA14 REACTOME:55360 ATLASONC:GC_GNA14 WIKI:GNA14 guanine nucleotide binding protein (G protein) alpha 15 (Gq class) HUGO:GNA15 HGNC:4383 ENTREZ:2769 UNIPROT:P30679 GENECARDS:GNA15 REACTOME:55362 KEGG:2769 ATLASONC:GC_GNA15 WIKI:GNA15 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 guanine nucleotide binding protein (G protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 guanine nucleotide binding protein (G protein) alpha activating activity polypeptide olfactory type HUGO:GNAL HGNC:4388 ENTREZ:2774 UNIPROT:P38405 GENECARDS:GNAL REACTOME:55364 ATLASONC:GC_GNAL WIKI:GNAL guanine nucleotide binding protein (G protein) alpha activating activity polypeptide O HUGO:GNAO1 HGNC:4389 ENTREZ:2775 UNIPROT:P09471 GENECARDS:GNAO1 REACTOME:55350 KEGG:2775 ATLASONC:GC_GNAO1 WIKI:GNAO1 guanine nucleotide binding protein (G protein) q polypeptide HUGO:GNAQ HGNC:4390 ENTREZ:2776 UNIPROT:P50148 GENECARDS:GNAQ REACTOME:55454 KEGG:2776 ATLASONC:GNAQID43280ch9q21 WIKI:GNAQ Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21640127 References_end</body> </html> </notes> <label text="Gαo*"/> <bbox w="30.0" h="20.0" x="17552.0" y="1838.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s301_wca1_wca2_sa200"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="30.0" h="20.0" x="17592.0" y="1838.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s302_wca1_wca2_sa201"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="30.0" h="20.0" x="17632.0" y="1838.0"/> </glyph> <glyph class="simple chemical" id="wca1_wca2_s303_wca1_wca2_sa202"> <label text="GTP"/> <bbox w="25.0" h="25.0" x="17549.5" y="1815.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s294_wca1_wca2_sa203"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: teratocarcinoma-derived growth factor 1 HUGO:TDGF1 HGNC:11701 ENTREZ:6997 UNIPROT:P13385 GENECARDS:TDGF1 REACTOME:52798 KEGG:6997 ATLASONC:GC_TDGF1 WIKI:TDGF1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CRIPTO-1*"/> <bbox w="80.0" h="40.0" x="17492.0" y="1737.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s314_wca1_wca2_csa14" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Cytoskeleton:E-Cadherin*:ECM or cell-cell contact:ITGA3:_alpha_-Catenin*:_beta_-Catenin*:p120* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: It has been shown that ITGA3 can interact with adherence junction PMID:22659456 PMID:19171760 PMID:10931041 s_wca2_re50:(MAP:survival) PMID:22659456 PMID:22007144 PMID:19171760 PMID:10931041 References_end</body> </html> </notes> <label text="(ECM-Integrin/adherence junction)"/> <bbox w="245.0" h="170.0" x="15421.0" y="1092.0"/> <glyph class="phenotype" id="wca1_wca2_s120_wca1_wca2_sa79"> <label text="ECM or cell-cell contact"/> <bbox w="80.0" h="30.0" x="15424.0" y="1105.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s116_wca1_wca2_sa80"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: integrin alpha 3 (antigen CD49C alpha 3 subunit of VLA-3 receptor) "antigen identified by monoclonal antibody J143" MSK18 HUGO:ITGA3 HGNC:6139 ENTREZ:3675 UNIPROT:P26006 GENECARDS:ITGA3 REACTOME:57565 KEGG:3675 ATLASONC:GC_ITGA3 WIKI:ITGA3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_MATRIX_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ITGA3"/> <bbox w="80.0" h="40.0" x="15503.0" y="1104.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s206_wca1_wca2_sa83"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 UVO Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 PMID:22007144 References_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="123.0" h="41.0" x="15443.0" y="1150.0"/> <glyph class="state variable" id="_242cc305-c637-4cfc-9319-4d745e553e44"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15561.0" y="1145.0"/> </glyph> <glyph class="state variable" id="_b13eaf1e-b477-40f4-b513-5a6f51d76d5d"> <state value="P" variable="S849"/> <bbox w="35.0" h="10.0" x="15427.46" y="1145.0"/> </glyph> <glyph class="state variable" id="_3a6fa950-36f5-45b1-a8a8-682ccd9f798d"> <state value="P" variable="S853"/> <bbox w="35.0" h="10.0" x="15548.5" y="1145.2201"/> </glyph> <glyph class="state variable" id="_da2897e7-cbae-4941-8036-01efa7f5b700"> <state value="P" variable="S855"/> <bbox w="35.0" h="10.0" x="15544.02" y="1186.0"/> </glyph> <glyph class="state variable" id="_027b8cbb-ec47-4013-be6e-e4a6fa423a3f"> <state value="P" variable="S840"/> <bbox w="35.0" h="10.0" x="15425.869" y="1186.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s118_wca1_wca2_sa85"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end Identifiers_begin: catenin (cadherin-associated protein) delta 1 HUGO:CTNND1 HGNC:2515 ENTREZ:1500 UNIPROT:O60716 GENECARDS:CTNND1 REACTOME:52998 KEGG:1500 ATLASONC:CTNND1ID40197ch11q11 WIKI:CTNND1 catenin (cadherin-associated protein) delta 2 (neural plakophilin-related arm-repeat protein) HUGO:CTNND2 HGNC:2516 ENTREZ:1501 UNIPROT:Q9UQB3 GENECARDS:CTNND2 KEGG:1501 ATLASONC:GC_CTNND2 WIKI:CTNND2 catenin (cadherin-associated protein) delta 2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19029934 References_end</body> </html> </notes> <label text="p120*"/> <bbox w="80.0" h="40.0" x="15439.0" y="1198.0"/> <glyph class="state variable" id="_00b77075-8ab5-474a-81c1-4d77c4f01b51"> <state value="" variable="S268"/> <bbox w="30.0" h="10.0" x="15424.492" y="1193.0"/> </glyph> <glyph class="state variable" id="_75a5b586-0097-46f2-a01d-a4e2db482bb5"> <state value="" variable="S269"/> <bbox w="30.0" h="10.0" x="15464.032" y="1193.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s184_wca1_wca2_sa86"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="15522.0" y="1198.0"/> <glyph class="state variable" id="_ebf19d26-2c92-4e74-90d5-887dc9f332fc"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="15549.404" y="1233.0"/> </glyph> <glyph class="state variable" id="_4bdf9a54-b595-4ca8-b4f2-be3de199496d"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="15588.882" y="1233.0"/> </glyph> <glyph class="state variable" id="_934c9f97-39d2-481d-8959-9f274a6e4b69"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="15589.5" y="1193.2147"/> </glyph> <glyph class="state variable" id="_fc057765-6c03-49f8-9d30-c2806cd63132"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="15549.532" y="1193.0"/> </glyph> <glyph class="state variable" id="_d73262cf-4694-4e81-8b22-4d09cd8f62c9"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="15509.992" y="1193.0"/> </glyph> <glyph class="state variable" id="_ee77a2c4-839d-40dc-80a9-dc5dd9367d06"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="15509.5" y="1232.7223"/> </glyph> <glyph class="state variable" id="_3cbe2443-55f8-4f2d-918e-0c6a9ae3d898"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="15587.0" y="1193.2147"/> </glyph> <glyph class="state variable" id="_c75999dc-8060-4090-b0c5-4703e1489c0d"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="15587.0" y="1193.2147"/> </glyph> <glyph class="state variable" id="_92a6cb1e-7f0b-4b8a-a23d-be406ff0c35e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15517.0" y="1213.0"/> </glyph> <glyph class="state variable" id="_040838b6-2d75-4339-afdc-89e36278f4e5"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="15507.492" y="1193.0"/> </glyph> <glyph class="state variable" id="_979f96f1-f89b-47bf-a1f5-948771838a9f"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="15587.0" y="1193.2147"/> </glyph> <glyph class="state variable" id="_e01e7d2e-537d-490e-8668-214ba8047622"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15517.0" y="1204.7157"/> </glyph> <glyph class="state variable" id="_6dd11ddc-68b7-4970-98cd-0dd9f7d8ae27"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="15587.0" y="1193.2147"/> </glyph> <glyph class="state variable" id="_c0933174-da9f-41e7-8403-7a0d238cb3a8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15517.0" y="1213.0"/> </glyph> <glyph class="state variable" id="_35308f0c-6564-4f24-858d-45ee0da7f3ed"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="15586.382" y="1233.0"/> </glyph> <glyph class="state variable" id="_c9b9ff2c-fb7d-4bd5-84ee-a80b4f64689f"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="15587.0" y="1193.2147"/> </glyph> </glyph> <glyph class="phenotype" id="wca1_wca2_s179_wca1_wca2_sa125"> <label text="Cytoskeleton"/> <bbox w="80.0" h="30.0" x="15581.0" y="1108.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s175_wca1_wca2_sa127"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: catenin (cadherin-associated protein) alpha 1 102kDa HUGO:CTNNA1 HGNC:2509 ENTREZ:1495 UNIPROT:P35221 GENECARDS:CTNNA1 REACTOME:53044 KEGG:1495 ATLASONC:GC_CTNNA1 WIKI:CTNNA1 catenin (cadherin-associated protein) alpha 2 HUGO:CTNNA2 HGNC:2510 ENTREZ:1496 UNIPROT:P26232 GENECARDS:CTNNA2 REACTOME:53046 KEGG:1496 WIKI:CTNNA2 catenin (cadherin-associated protein) alpha 3 HUGO:CTNNA3 HGNC:2511 ENTREZ:29119 UNIPROT:Q9UI47 GENECARDS:CTNNA3 KEGG:29119 ATLASONC:GC_CTNNA3 WIKI:CTNNA3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: catenin (cadherin-associated protein) alpha 1 102kDa HUGO:CTNNA1 HGNC:2509 ENTREZ:1495 UNIPROT:P35221 GENECARDS:CTNNA1 REACTOME:53044 KEGG:1495 ATLASONC:GC_CTNNA1 WIKI:CTNNA1 catenin (cadherin-associated protein) alpha 2 HUGO:CTNNA2 HGNC:2510 ENTREZ:1496 UNIPROT:P26232 GENECARDS:CTNNA2 REACTOME:53046 KEGG:1496 WIKI:CTNNA2 catenin (cadherin-associated protein) alpha 3 HUGO:CTNNA3 HGNC:2511 ENTREZ:29119 UNIPROT:Q9UI47 GENECARDS:CTNNA3 KEGG:29119 ATLASONC:GC_CTNNA3 WIKI:CTNNA3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="α-Catenin*"/> <bbox w="80.0" h="40.0" x="15570.0" y="1149.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s315_wca1_wca2_csa23" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK1*:LRP6:TMEM198 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: TMEM198 can aggegrate LRP6 in signalosome-like structures and recrute CK1 family members PMID:21536646 s_wca2_re57(MAP:survival): This complex is able to activate target genes of the canonical wnt pathway References_end</body> </html> </notes> <label text="(Signalosome-like)"/> <bbox w="106.0" h="278.0" x="15479.0" y="2370.0"/> <glyph class="macromolecule" id="wca1_wca2_s316_wca1_wca2_sa151"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transmembrane protein 198 HUGO:TMEM198 HGNC:33704 ENTREZ:130612 UNIPROT:Q66K66 GENECARDS:TMEM198 KEGG:130612 WIKI:TMEM198 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TMEM198"/> <bbox w="80.0" h="40.0" x="15494.5" y="2384.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s317_wca1_wca2_sa152"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LRP6"/> <bbox w="80.0" h="50.0" x="15494.5" y="2426.0"/> <glyph class="state variable" id="_3591a32f-25e8-46eb-83f1-3c735a2e36ad"> <state value="" variable="T1572"/> <bbox w="35.0" h="10.0" x="15477.0" y="2445.9602"/> </glyph> <glyph class="state variable" id="_a577f8d3-3393-469b-bff3-93eba259e931"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="15517.032" y="2421.0"/> </glyph> <glyph class="state variable" id="_f2c02936-8015-4ee9-afe4-f84a497ee830"> <state value="" variable="S1544"/> <bbox w="35.0" h="10.0" x="15557.0" y="2421.2686"/> </glyph> <glyph class="state variable" id="_ee047085-e603-4bad-bc03-492d724cb140"> <state value="" variable="T1548"/> <bbox w="35.0" h="10.0" x="15557.0" y="2459.4373"/> </glyph> <glyph class="state variable" id="_3f468d66-5fc8-4b66-8953-c106bc0cce42"> <state value="P" variable="T1493"/> <bbox w="40.0" h="10.0" x="15554.5" y="2421.2686"/> </glyph> <glyph class="state variable" id="_3cbdc5e5-f1b2-4c2c-ae49-7044f9e247c4"> <state value="P" variable="T1479"/> <bbox w="40.0" h="10.0" x="15474.992" y="2421.0"/> </glyph> <glyph class="unit of information" id="_f94d06c7-1519-46cd-b8cc-d75d0eb12113"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="15512.0" y="2421.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s317_wca1_wca2_sa153"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LRP6"/> <bbox w="80.0" h="50.0" x="15494.5" y="2519.0"/> <glyph class="state variable" id="_1eea35be-6b2f-4466-9293-b024f7b00966"> <state value="" variable="T1572"/> <bbox w="35.0" h="10.0" x="15477.0" y="2538.9602"/> </glyph> <glyph class="state variable" id="_2507390c-5472-4229-a1f5-cf48c70cb481"> <state value="" variable="S1490"/> <bbox w="35.0" h="10.0" x="15517.032" y="2514.0"/> </glyph> <glyph class="state variable" id="_dce8d87a-d13d-47b2-a9bc-91b84a04e605"> <state value="" variable="S1544"/> <bbox w="35.0" h="10.0" x="15557.0" y="2514.2686"/> </glyph> <glyph class="state variable" id="_6452074b-6e74-4cf3-b926-f59be6f8ba1e"> <state value="" variable="T1548"/> <bbox w="35.0" h="10.0" x="15557.0" y="2552.4373"/> </glyph> <glyph class="state variable" id="_16a09dee-95d9-48bf-8e0b-6f026ef81ee9"> <state value="P" variable="T1493"/> <bbox w="40.0" h="10.0" x="15554.5" y="2514.2686"/> </glyph> <glyph class="state variable" id="_4df86f96-3a8c-43f6-ad9e-56ad9b9c85e0"> <state value="P" variable="T1479"/> <bbox w="40.0" h="10.0" x="15474.992" y="2514.0"/> </glyph> <glyph class="unit of information" id="_ac258cbd-80bc-4d22-9da8-97ef191540bf"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="15512.0" y="2514.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s316_wca1_wca2_sa154"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transmembrane protein 198 HUGO:TMEM198 HGNC:33704 ENTREZ:130612 UNIPROT:Q66K66 GENECARDS:TMEM198 KEGG:130612 WIKI:TMEM198 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TMEM198"/> <bbox w="80.0" h="40.0" x="15494.5" y="2477.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s230_wca1_wca2_sa155"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end</body> </html> Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end</body> </html> Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end</body> </html> </notes> <label text="CK1*"/> <bbox w="80.0" h="40.0" x="15492.5" y="2569.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s318_wca1_wca2_csa12" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:WNT*:XFZ3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re30(MAP:survival): Shown in Xenopus embryos that dimerisation of XFZ3 correlates with activation. This phenomenon is described once in: PMID:12734397 References_end</body> </html> </notes> <label text="(Xfz3 dimer)"/> <bbox w="110.0" h="100.0" x="17423.0" y="733.0"/> <glyph class="macromolecule" id="wca1_wca2_s319_wca1_wca2_sa70"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Xenopus homologue References_end</body> </html> </notes> <label text="XFZ3"/> <bbox w="80.0" h="50.0" x="17431.5" y="750.0"/> <glyph class="unit of information" id="_005e211b-a92f-4095-addc-d415d1da4cd5"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="17449.0" y="745.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s319_wca1_wca2_sa71"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Xenopus homologue References_end</body> </html> </notes> <label text="XFZ3"/> <bbox w="80.0" h="50.0" x="17441.5" y="760.0"/> <glyph class="unit of information" id="_23c3de56-c7f2-4034-9228-0f4e70fd92db"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="17459.0" y="755.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s97_wca1_wca2_sa73"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 2 HUGO:WNT2 HGNC:12780 ENTREZ:7472 UNIPROT:P09544 GENECARDS:WNT2 REACTOME:67378 KEGG:7472 ATLASONC:GC_WNT2 WIKI:WNT2 wingless-type MMTV integration site family member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 wingless-type MMTV integration site family member 3A HUGO:WNT3A HGNC:15983 ENTREZ:89780 UNIPROT:P56704 GENECARDS:WNT3A REACTOME:67362 ATLASONC:GC_WNT3A WIKI:WNT3A wingless-type MMTV integration site family member 4 HUGO:WNT4 HGNC:12783 ENTREZ:54361 UNIPROT:P56705 GENECARDS:WNT4 REACTOME:67382 KEGG:54361 ATLASONC:GC_WNT4 WIKI:WNT4 wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A wingless-type MMTV integration site family member 5B HUGO:WNT5B HGNC:16265 ENTREZ:81029 UNIPROT:Q9H1J7 GENECARDS:WNT5B ATLASONC:GC_WNT5B WIKI:WNT5B wingless-type MMTV integration site family member 6 HUGO:WNT6 HGNC:12785 ENTREZ:7475 UNIPROT:Q9Y6F9 GENECARDS:WNT6 REACTOME:67384 ATLASONC:GC_WNT6 WIKI:WNT6 wingless-type MMTV integration site family member 7A HUGO:WNT7A HGNC:12786 ENTREZ:7476 UNIPROT:O00755 GENECARDS:WNT7A REACTOME:67368 ATLASONC:GC_WNT7A WIKI:WNT7A wingless-type MMTV integration site family member 7B HUGO:WNT7B HGNC:12787 ENTREZ:7477 UNIPROT:P56706 GENECARDS:WNT7B REACTOME:67370 ATLASONC:GC_WNT7B WIKI:WNT7B wingless-type MMTV integration site family member 8A HUGO:WNT8A HGNC:12788 ENTREZ:7478 UNIPROT:Q9H1J5 GENECARDS:WNT8A REACTOME:67372 KEGG:7478 ATLASONC:GC_WNT8A WIKI:WNT8A wingless-type MMTV integration site family member 8B HUGO:WNT8B HGNC:12789 ENTREZ:7479 UNIPROT:Q93098 GENECARDS:WNT8B REACTOME:67374 ATLASONC:GC_WNT8B WIKI:WNT8B wingless-type MMTV integration site family member 9A HUGO:WNT9A HGNC:12778 ENTREZ:7483 UNIPROT:O14904 GENECARDS:WNT9A REACTOME:67350 KEGG:7483 ATLASONC:GC_WNT9A WIKI:WNT9A wingless-type MMTV integration site family member 9B HUGO:WNT9B HGNC:12779 ENTREZ:7484 UNIPROT:O14905 GENECARDS:WNT9B REACTOME:67352 KEGG:7484 ATLASONC:GC_WNT9B WIKI:WNT9B wingless-type MMTV integration site family member 10A HUGO:WNT10A HGNC:13829 ENTREZ:80326 UNIPROT:Q9GZT5 GENECARDS:WNT10A REACTOME:67356 KEGG:80326 ATLASONC:GC_WNT10A WIKI:WNT10A wingless-type MMTV integration site family member 10B HUGO:WNT10B HGNC:12775 ENTREZ:7480 UNIPROT:O00744 GENECARDS:WNT10B REACTOME:67358 KEGG:7480 ATLASONC:GC_WNT10B WIKI:WNT10B wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 wingless-type MMTV integration site family member 16 HUGO:WNT16 HGNC:16267 ENTREZ:51384 UNIPROT:Q9UBV4 GENECARDS:WNT16 REACTOME:67354 ATLASONC:GC_WNT16 WIKI:WNT16 HGNC/16267 wingless-type MMTV integration site family member 5 WNT5A antisense RNA 1 HUGO:WNT5A-AS1 HGNC:40616 ENTREZ:100874008 GENECARDS:WNT5A-AS1 WIKI:WNT5A-AS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Class I: WNT-1/3a/7/8a/8b activates canonical PMID:14747478 PMID:15265686 PMID:8655584 PMID:22017973 PMID:17127310 References_end</body> </html> </notes> <label text="WNT*"/> <bbox w="40.0" h="20.0" x="17458.0" y="740.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s320_wca1_wca2_csa13" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:XFZ7 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="(Xfz7_dimer)"/> <bbox w="90.0" h="100.0" x="17643.0" y="840.0"/> <glyph class="macromolecule" id="wca1_wca2_s321_wca1_wca2_sa75"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Xenopus homologue References_end</body> </html> </notes> <label text="XFZ7"/> <bbox w="80.0" h="50.0" x="17648.0" y="846.0"/> <glyph class="unit of information" id="_3bb3fd20-92e6-437c-b85a-df43167dd7f5"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="17665.5" y="841.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s321_wca1_wca2_sa76"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Xenopus homologue References_end</body> </html> </notes> <label text="XFZ7"/> <bbox w="80.0" h="50.0" x="17649.0" y="867.0"/> <glyph class="unit of information" id="_3186fe26-6bca-46cd-81fd-d835883056a4"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="17666.5" y="862.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s322_wca1_wca2_csa28" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC:AXIN*:CK1_alpha_*:GSK3* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re65(MAP:survival): Ubiquitination increases binding of APC with AXIN. PMID:23277359 s_wca2_re66:(MAP:survival) The destruction is part of the canonical wnt pathway when no WNT ligand is bound to the receptor. This complex makes sure that beta-catenin is degraded. References_end</body> </html> </notes> <label text="(Destruction complex)"/> <bbox w="211.0" h="121.0" x="16456.0" y="1060.5"/> <glyph class="macromolecule" id="wca1_wca2_s257_wca1_wca2_sa176"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="16471.0" y="1074.5"/> <glyph class="state variable" id="_64362c63-1062-47da-a242-4d0079eca99e"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="16458.992" y="1069.5"/> </glyph> <glyph class="state variable" id="_a459df0f-75a3-4621-b4ac-86646c28979d"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="16498.531" y="1069.5"/> </glyph> <glyph class="state variable" id="_2f81c485-0599-43c7-ab85-013dceb8c314"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="16536.0" y="1069.7147"/> </glyph> <glyph class="state variable" id="_cb1e259c-69bb-489b-8a5e-8e1b0d5dea42"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="16535.38" y="1109.5"/> </glyph> <glyph class="state variable" id="_f8f0cfe9-db0d-47c6-9ea2-d8101ae26e88"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="16495.904" y="1109.5"/> </glyph> <glyph class="state variable" id="_25306816-ecfb-4573-b60f-8e15ef8cc0db"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="16456.0" y="1109.2223"/> </glyph> <glyph class="state variable" id="_e925f452-58e4-4c79-a6a9-4e6b932b327b"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="16498.404" y="1109.5"/> </glyph> <glyph class="state variable" id="_4501f08d-06f4-4352-aff5-88231063de64"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="16537.88" y="1109.5"/> </glyph> <glyph class="state variable" id="_804f2d94-0140-42dd-a2a2-5fb7b8fc7842"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="16543.5" y="1069.7147"/> </glyph> <glyph class="state variable" id="_c7627822-19c6-42b4-9ce5-cced213b264d"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="16458.5" y="1109.2223"/> </glyph> <glyph class="state variable" id="_02d660f8-f663-4da2-835b-77337dabfd38"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="16463.992" y="1069.5"/> </glyph> <glyph class="state variable" id="_e7325c4e-e046-4ba5-bebd-88ec877382a4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16466.0" y="1069.5"/> </glyph> <glyph class="state variable" id="_e3c53be3-078e-47bf-a258-040049bae138"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16546.0" y="1069.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca2_s258_wca1_wca2_sa177"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end Identifiers_begin: glycogen synthase kinase 3 alpha HUGO:GSK3A HGNC:4616 ENTREZ:2931 UNIPROT:P49840 GENECARDS:GSK3A REACTOME:69666 ATLASONC:GC_GSK3A WIKI:GSK3A glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19366350 References_end</body> </html> </notes> <label text="GSK3*"/> <bbox w="80.0" h="40.0" x="16556.0" y="1072.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s259_wca1_wca2_sa178"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:7641885 References_end</body> </html> </notes> <label text="CK1α*"/> <bbox w="80.0" h="40.0" x="16559.0" y="1116.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s260_wca1_wca2_sa179"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="16475.75" y="1119.0"/> <glyph class="state variable" id="_5f1cca07-9e2a-4aa4-9798-01b786f1cc47"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="16537.63" y="1154.0"/> </glyph> <glyph class="state variable" id="_4e9d8dbf-4da9-4be0-b4ac-ed5f26ce8fc5"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="16458.742" y="1114.0"/> </glyph> <glyph class="state variable" id="_43bb523a-96ce-4fbb-9e96-d0d045ae2f00"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="16538.25" y="1114.2147"/> </glyph> <glyph class="state variable" id="_5a7f352e-8e7e-4d06-ae6c-9f9464bfc08c"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="16498.154" y="1154.0"/> </glyph> <glyph class="state variable" id="_f19df11f-3269-4b5a-9c9e-1c6cb189aa89"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="16498.281" y="1114.0"/> </glyph> <glyph class="state variable" id="_b0f6af46-df17-4768-9288-08e29efe2a3c"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="16458.25" y="1153.7223"/> </glyph> <glyph class="state variable" id="_4053804c-ad04-4015-b871-73bca1460863"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16550.75" y="1114.0"/> </glyph> <glyph class="state variable" id="_1a30ee60-2bee-48a7-b999-9f9ee8846e7a"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="16538.25" y="1153.1306"/> </glyph> <glyph class="state variable" id="_b48139c7-288c-47fa-8dde-4670cd94cbe3"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="16458.25" y="1153.7223"/> </glyph> <glyph class="state variable" id="_9c47eafc-48e1-4686-83ec-ba6c7c3957a4"> <state value="Ub" variable="K63"/> <bbox w="35.0" h="10.0" x="16458.742" y="1114.0"/> </glyph> <glyph class="state variable" id="_428c6ee9-3b79-4a52-a0d3-884f98ed9b20"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="16458.742" y="1114.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca2_s323_wca1_wca2_csa21" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK2_alpha_:CK2_alpha_*:CK2_beta_* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="(CK2)"/> <bbox w="84.0" h="88.0" x="15836.0" y="1291.0"/> <glyph class="macromolecule" id="wca1_wca2_s194_wca1_wca2_sa138"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 alpha 1 polypeptide HUGO:CSNK2A1 HGNC:2457 ENTREZ:1457 UNIPROT:P68400 GENECARDS:CSNK2A1 REACTOME:201673 KEGG:1457 ATLASONC:GC_CSNK2A1 WIKI:CSNK2A1 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 alpha 1 polypeptide HUGO:CSNK2A1 HGNC:2457 ENTREZ:1457 UNIPROT:P68400 GENECARDS:CSNK2A1 REACTOME:201673 KEGG:1457 ATLASONC:GC_CSNK2A1 WIKI:CSNK2A1 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2α*"/> <bbox w="40.0" h="30.0" x="15846.0" y="1298.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s195_wca1_wca2_sa139"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 alpha prime polypeptide HUGO:CSNK2A2 HGNC:2459 ENTREZ:1459 UNIPROT:P19784 GENECARDS:CSNK2A2 REACTOME:57879 KEGG:1459 ATLASONC:GC_CSNK2A2 WIKI:CSNK2A2 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 alpha prime polypeptide HUGO:CSNK2A2 HGNC:2459 ENTREZ:1459 UNIPROT:P19784 GENECARDS:CSNK2A2 REACTOME:57879 KEGG:1459 ATLASONC:GC_CSNK2A2 WIKI:CSNK2A2 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2α'*"/> <bbox w="40.0" h="30.0" x="15879.0" y="1298.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s324_wca1_wca2_sa140"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2β*"/> <bbox w="40.0" h="30.0" x="15846.0" y="1330.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca2_s324_wca1_wca2_sa141"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2β*"/> <bbox w="40.0" h="30.0" x="15879.0" y="1330.0"/> </glyph> </glyph> <glyph class="phenotype" id="wca1_s_wca2_s136_wca1_wca2_sa105" compartmentRef="wca1_wca2_c1_wca1_wca2_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TGFβ pathway"/> <bbox w="80.0" h="30.0" x="15630.0" y="1836.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca2_s138_wca1_wca2_sa107" compartmentRef="wca1_wca2_c3_wca1_wca2_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: s_wca2_re43(MAP:survival): Y654-phosphorylated isoform is able to induce canonical TCF/LEF transcription PMID:22203675 References_end</body> </html> </notes> <label text="TCF_LEF transcriptional regulation"/> <bbox w="80.0" h="30.0" x="16277.0" y="1845.0"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s215_wca1_wca3_sa169" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re41:(MAP:survival) PMID:22045851 s_wca3_re132(MAP:survival): Actually the whole MIR-34 family targets AXIN2 PMID:22421157 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 34a HUGO:MIR34A HGNC:31635 ENTREZ:407040 GENECARDS:MIR34A KEGG:407040 ATLASONC:GC_MIR34A WIKI:MIR34A Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR34A"/> <bbox w="90.0" h="25.0" x="13256.0" y="4768.5"/> <glyph class="unit of information" id="_00b4bf0b-01a3-4daf-823b-c6c88aaa8ee5"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="13286.0" y="4763.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s217_wca1_wca3_sa171" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re42:(MAP:survival) PMID:22045851 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 34b HUGO:MIR34B HGNC:31636 ENTREZ:407041 GENECARDS:MIR34B KEGG:407041 ATLASONC:GC_MIR34B WIKI:MIR34B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR34B"/> <bbox w="90.0" h="25.0" x="13256.0" y="4802.0"/> <glyph class="unit of information" id="_77ddaf08-dcec-4d7e-adfe-3a49a13ff2a1"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="13286.0" y="4797.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s219_wca1_wca3_sa173" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re43:(MAP:survival) PMID:22045851 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 34c HUGO:MIR34C HGNC:31637 ENTREZ:407042 GENECARDS:MIR34C KEGG:407042 ATLASONC:GC_MIR34C WIKI:MIR34C Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR34C"/> <bbox w="90.0" h="25.0" x="13260.5" y="4835.5"/> <glyph class="unit of information" id="_622d9f2b-3547-49a3-a470-24d8af6799b2"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="13290.5" y="4830.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s646_wca1_wca3_sa448" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re159(MAP:survival): LEF1 has been identified to be involved in transcription of the MIR371-373 cluster. Only unknown if either P300 or CTBP is involved. PMID:22020335 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 372 HUGO:MIR372 HGNC:31786 ENTREZ:442917 GENECARDS:MIR372 KEGG:442917 ATLASONC:GC_MIR372 WIKI:MIR372 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR372"/> <bbox w="90.0" h="25.0" x="13260.5" y="5079.5"/> <glyph class="unit of information" id="_41e6d64f-19e2-4199-a022-dc273a7ba698"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="13290.5" y="5074.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s647_wca1_wca3_sa449" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re160(MAP:survival): LEF1 has been identified to be involved in transcription of the MIR371-373 cluster. Only unknown if either P300 or CTBP is involved. PMID:22020335 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 373 HUGO:MIR373 HGNC:31787 ENTREZ:442918 GENECARDS:MIR373 KEGG:442918 ATLASONC:GC_MIR373 WIKI:MIR373 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR373"/> <bbox w="90.0" h="25.0" x="13260.5" y="5116.5"/> <glyph class="unit of information" id="_1db6750c-2792-4085-bf73-e3161cfc3d4b"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="13290.5" y="5111.5"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s15_wca1_wca3_csa8" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL9:PYGO*:_beta_-Catenin* Identifiers_end References_begin: s_wca3_re10(MAP:survival): P300 acetylates beta-catenin PMID:15060161 s_wca3_re11(MAP:survival): CBP acetylates beta-catenin PMID:11973335 s_wca3_re114(MAP:survival): KLF8 recruits P300 PMID:22761862 PMID:20107328 s_wca3_re127:(MAP:survival) PMID:19901072 PMID:19751731 References_end</body> </html> </notes> <label text="BCL9:PYGO*:β-Catenin*"/> <bbox w="105.0" h="175.0" x="14209.429" y="3810.0"/> <glyph class="macromolecule" id="wca1_wca3_s18_wca1_wca3_sa68"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: B-cell CLL/lymphoma 9 HUGO:BCL9 HGNC:1008 ENTREZ:607 UNIPROT:O00512 GENECARDS:BCL9 KEGG:607 ATLASONC:BCL9ID466 WIKI:BCL9 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BCL9"/> <bbox w="80.0" h="40.0" x="14222.429" y="3860.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s16_wca1_wca3_sa69"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: pygopus homolog 1 (Drosophila) HUGO:PYGO1 HGNC:30256 ENTREZ:26108 UNIPROT:Q9Y3Y4 GENECARDS:PYGO1 WIKI:PYGO1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PYGO*"/> <bbox w="80.0" h="40.0" x="14222.429" y="3820.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s117_wca1_wca3_sa70"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="14222.429" y="3900.0"/> <glyph class="state variable" id="_9f53e7e9-674a-44c8-8790-ed389f59d0d0"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="14249.833" y="3935.0"/> </glyph> <glyph class="state variable" id="_dbe576c6-12da-46ad-a675-3f08055c7093"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="14289.311" y="3935.0"/> </glyph> <glyph class="state variable" id="_f213300a-c672-4af8-ac2f-fc4c84c0b477"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="14289.929" y="3895.2148"/> </glyph> <glyph class="state variable" id="_b42b9156-6996-47eb-9c5f-1d040eaaba3f"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="14249.961" y="3895.0"/> </glyph> <glyph class="state variable" id="_156f3b39-f362-4268-8d13-56de42ccbff7"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="14210.421" y="3895.0"/> </glyph> <glyph class="state variable" id="_2d4372ce-7579-49aa-9603-8e44575eaf8b"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="14209.929" y="3934.7224"/> </glyph> <glyph class="state variable" id="_f86f40ce-e6f1-4a76-81c4-feb3377c3c2b"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="14287.429" y="3895.2148"/> </glyph> <glyph class="state variable" id="_4b9691d0-a93f-4390-91c2-55e5c9ca821a"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="14287.429" y="3895.2148"/> </glyph> <glyph class="state variable" id="_c69c9cd9-ac65-49d3-b958-dbe1126514e2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14217.429" y="3915.0"/> </glyph> <glyph class="state variable" id="_0e28b106-3f23-4c97-882f-9f5d957ec879"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="14207.921" y="3895.0"/> </glyph> <glyph class="state variable" id="_83704c93-4c99-4976-8b6a-7bf56f3e1b58"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="14287.429" y="3895.2148"/> </glyph> <glyph class="state variable" id="_5ed9d0ab-d76f-4d45-b26c-0a4aee92d86e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14217.429" y="3906.7158"/> </glyph> <glyph class="state variable" id="_79b299e5-fb81-44a9-b104-0591b30228b3"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="14287.429" y="3895.2148"/> </glyph> <glyph class="state variable" id="_cceead92-e02f-4849-9fd2-d8c31650a696"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14217.429" y="3915.0"/> </glyph> <glyph class="state variable" id="_d0b59c4c-bc3a-46fc-821f-4fc8d3acc2be"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="14286.811" y="3935.0"/> </glyph> <glyph class="state variable" id="_888af6b6-63a7-4982-bc96-ce41c0335105"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="14287.429" y="3895.2148"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s29_wca1_wca3_csa4" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HDAC1_2*:TLE* Identifiers_end References_begin: s_wca3_re6(MAP:survival): PMID:16169192 B-catenin competes with TLE for Lef-1 PMID:15768032 CBP-and P300-mediated transcription different cell fates PMID:20530697 (phosphorylated) C-JUN can bind to TCF4 PMID:18347071 PMID:16007074 References_end</body> </html> </notes> <label text="HDAC1_2*:TLE*"/> <bbox w="100.0" h="120.0" x="13967.4375" y="4823.0"/> <glyph class="macromolecule" id="wca1_wca3_s27_wca1_wca3_sa23"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: histone deacetylase 1 HUGO:HDAC1 HGNC:4852 ENTREZ:3065 UNIPROT:Q13547 GENECARDS:HDAC1 REACTOME:56408 KEGG:3065 ATLASONC:GC_HDAC1 WIKI:HDAC1 HUGO:HDAC2 HGNC:4853 ENTREZ:3066 UNIPROT:Q92769 GENECARDS:HDAC2 REACTOME:56410 KEGG:3066 ATLASONC:HDAC2ID40803ch6q22 WIKI:HDAC2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HDAC1_2*"/> <bbox w="80.0" h="40.0" x="13977.4375" y="4836.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s358_wca1_wca3_sa24"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transducin-like enhancer of split 1 (E(sp1) homolog Drosophila) "transducin-like enhancer of split 1 homolog of Drosophila E(sp1)" HUGO:TLE1 HGNC:11837 ENTREZ:7088 UNIPROT:Q04724 GENECARDS:TLE1 REACTOME:66083 KEGG:7088 ATLASONC:GC_TLE1 WIKI:TLE1 transducin-like enhancer of split 2 (E(sp1) homolog Drosophila) HUGO:TLE2 HGNC:11838 ENTREZ:7089 UNIPROT:Q04725 GENECARDS:TLE2 REACTOME:66085 KEGG:7089 WIKI:TLE2 transducin-like enhancer of split 3 (E(sp1) homolog Drosophila) HUGO:TLE3 HGNC:11839 ENTREZ:7090 UNIPROT:Q04726 GENECARDS:TLE3 REACTOME:405165 KEGG:7090 ATLASONC:GC_TLE3 WIKI:TLE3 transducin-like enhancer of split 4 (E(sp1) homolog Drosophila) HUGO:TLE4 HGNC:11840 ENTREZ:7091 UNIPROT:Q04727 GENECARDS:TLE4 REACTOME:66089 KEGG:7091 WIKI:TLE4 amino-terminal enhancer of split GRG5 TLE5 HUGO:AES HGNC:307 ENTREZ:166 UNIPROT:Q08117 GENECARDS:AES KEGG:166 ATLASONC:GC_AES WIKI:AES transducin-like enhancer of split 6 (E(sp1) homolog Drosophila) HUGO:TLE6 HGNC:30788 ENTREZ:79816 UNIPROT:Q9H808 GENECARDS:TLE6 KEGG:79816 ATLASONC:GC_TLE6 WIKI:TLE6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: References_begin non-DNA binding transcription factor PMID:20925119 References-end References_end</body> </html> </notes> <label text="TLE*"/> <bbox w="80.0" h="40.0" x="13977.4375" y="4877.0"/> <glyph class="state variable" id="_0c5315fb-8903-4b8a-9da1-fadeca83d7d0"> <state value="" variable="S239"/> <bbox w="30.0" h="10.0" x="13962.93" y="4872.0"/> </glyph> <glyph class="state variable" id="_165cb448-fbe0-44d4-bb3a-4390fe74afb4"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="14047.4375" y="4872.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s85_wca1_wca3_csa2" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL9:PYGO*:_beta_-Catenin*:p300* Identifiers_end References_begin: s_wca3_re10(MAP:survival): P300 acetylates beta-catenin PMID:15060161 s_wca3_re64(MAP:survival): Under pathological conditions this complex will be formed. This complex has synergistic positive effect on myc gene expression. PMID:15576399 s_wca3_re170:(MAP:survival) PMID:18347071 References_end</body> </html> </notes> <label text="BCL9:PYGO*:β-Catenin*:p300*"/> <bbox w="105.0" h="217.0" x="13510.5" y="3797.0"/> <glyph class="macromolecule" id="wca1_wca3_s101_wca1_wca3_sa14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: B-cell CLL/lymphoma 9 HUGO:BCL9 HGNC:1008 ENTREZ:607 UNIPROT:O00512 GENECARDS:BCL9 KEGG:607 ATLASONC:BCL9ID466 WIKI:BCL9 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BCL9"/> <bbox w="80.0" h="40.0" x="13525.5625" y="3885.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s102_wca1_wca3_sa15"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: pygopus homolog 1 (Drosophila) HUGO:PYGO1 HGNC:30256 ENTREZ:26108 UNIPROT:Q9Y3Y4 GENECARDS:PYGO1 WIKI:PYGO1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PYGO*"/> <bbox w="80.0" h="40.0" x="13525.5625" y="3845.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s119_wca1_wca3_sa16"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="13525.0625" y="3924.0"/> <glyph class="state variable" id="_30170476-b111-4a27-b0e1-e060f983f6e8"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="13552.467" y="3959.0"/> </glyph> <glyph class="state variable" id="_fc998d05-dbae-4ba7-9e6f-deb71f22d073"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="13591.944" y="3959.0"/> </glyph> <glyph class="state variable" id="_b5e32aa1-1d8c-4988-967c-4a8e84807ece"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="13592.5625" y="3919.2148"/> </glyph> <glyph class="state variable" id="_e2db94e6-4e35-4b61-97c2-1cd6ccb370fb"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="13552.595" y="3919.0"/> </glyph> <glyph class="state variable" id="_59481a24-db95-45ef-b74e-9624694cc061"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="13513.055" y="3919.0"/> </glyph> <glyph class="state variable" id="_241cd94e-3771-413b-9640-28db3784df10"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="13512.5625" y="3958.7224"/> </glyph> <glyph class="state variable" id="_fcbd5856-849d-43e8-8580-66a370091819"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="13590.0625" y="3919.2148"/> </glyph> <glyph class="state variable" id="_53ec8403-84a7-43e1-8852-988934ce2181"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="13590.0625" y="3919.2148"/> </glyph> <glyph class="state variable" id="_cf86652c-cd3d-43f8-9987-c073918af578"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13520.0625" y="3939.0"/> </glyph> <glyph class="state variable" id="_936560ea-3b7a-4cf5-b3f6-f034391555eb"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="13510.555" y="3919.0"/> </glyph> <glyph class="state variable" id="_f4bb2faf-aa1b-4bdb-8c31-d0a314ee72a9"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="13590.0625" y="3919.2148"/> </glyph> <glyph class="state variable" id="_0124c98b-5a61-4028-b8cf-729fa45142d1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13520.0625" y="3930.7158"/> </glyph> <glyph class="state variable" id="_6c55837f-64a4-4353-a0db-0903ecefbc42"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="13590.0625" y="3919.2148"/> </glyph> <glyph class="state variable" id="_7772f194-0fd5-4837-b30e-27c066ba4b8e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13520.0625" y="3939.0"/> </glyph> <glyph class="state variable" id="_83a3ca5d-a6b6-45e4-864f-11b0bd1a4f73"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="13589.444" y="3959.0"/> </glyph> <glyph class="state variable" id="_9ceb3dbb-3238-4b8f-a4a0-8064a543d5c5"> <state value="Ac" variable="K345"/> <bbox w="40.0" h="10.0" x="13585.0625" y="3919.2148"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s103_wca1_wca3_sa72"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: E1A binding protein p300 HUGO:EP300 HGNC:3373 ENTREZ:2033 UNIPROT:Q09472 GENECARDS:EP300 REACTOME:61164 KEGG:2033 ATLASONC:P300ID97 WIKI:EP300 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:HIF1 MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="p300*"/> <bbox w="80.0" h="40.0" x="13525.125" y="3805.25"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s93_wca1_wca3_csa10" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL9:CBP*:PYGO*:_beta_-Catenin* Identifiers_end References_begin: s_wca3_re11(MAP:survival): CBP acetylates beta-catenin PMID:11973335 References_end</body> </html> </notes> <label text="BCL9:CBP*:PYGO*:β-Catenin*"/> <bbox w="113.0" h="245.0" x="14978.34" y="3724.0"/> <glyph class="macromolecule" id="wca1_wca3_s89_wca1_wca3_sa77"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: B-cell CLL/lymphoma 9 HUGO:BCL9 HGNC:1008 ENTREZ:607 UNIPROT:O00512 GENECARDS:BCL9 KEGG:607 ATLASONC:BCL9ID466 WIKI:BCL9 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BCL9"/> <bbox w="80.0" h="40.0" x="14991.34" y="3825.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s90_wca1_wca3_sa78"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: pygopus homolog 1 (Drosophila) HUGO:PYGO1 HGNC:30256 ENTREZ:26108 UNIPROT:Q9Y3Y4 GENECARDS:PYGO1 WIKI:PYGO1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PYGO*"/> <bbox w="80.0" h="40.0" x="14991.34" y="3785.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s127_wca1_wca3_sa79"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="14991.34" y="3865.0"/> <glyph class="state variable" id="_87b4f82c-3c1a-421e-908e-3b1c8afbee24"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="15018.744" y="3900.0"/> </glyph> <glyph class="state variable" id="_d4643907-01d6-4995-b058-7543ac2c7e67"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="15058.222" y="3900.0"/> </glyph> <glyph class="state variable" id="_0a5fee4d-a1ec-4ada-89c3-8410bdff6c77"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="15058.84" y="3860.2148"/> </glyph> <glyph class="state variable" id="_f974db68-cafb-41b2-9ea6-332670ab6471"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="15018.872" y="3860.0"/> </glyph> <glyph class="state variable" id="_50aa6de3-c359-4a2d-b840-d751f2a4d876"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="14979.332" y="3860.0"/> </glyph> <glyph class="state variable" id="_43676fa1-b037-4725-a55b-39706f84b17d"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="14978.84" y="3899.7224"/> </glyph> <glyph class="state variable" id="_500b635c-951c-4b89-8100-d723b5077d8a"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="15056.34" y="3860.2148"/> </glyph> <glyph class="state variable" id="_626ddfb4-9822-46f4-b1c2-2b3899ee2fb3"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="15056.34" y="3860.2148"/> </glyph> <glyph class="state variable" id="_f4771a12-2d6e-49f7-8fc4-b27ce2286e28"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14986.34" y="3880.0"/> </glyph> <glyph class="state variable" id="_13dc1f86-c4eb-4062-94c6-a23a10871610"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="14976.832" y="3860.0"/> </glyph> <glyph class="state variable" id="_99f4db8f-e2bb-4f33-94f7-b1e2cb110034"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="15056.34" y="3860.2148"/> </glyph> <glyph class="state variable" id="_712f29ec-450d-4859-85e6-5227e256e04b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14986.34" y="3871.7158"/> </glyph> <glyph class="state variable" id="_d3f8d33e-b4cf-42e6-8ecf-d680df5202dd"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="15056.34" y="3860.2148"/> </glyph> <glyph class="state variable" id="_5ef6694c-d492-463d-a83c-85ee6c106319"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14986.34" y="3880.0"/> </glyph> <glyph class="state variable" id="_637f21d4-e637-493d-a2a4-f717e41270da"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="15055.722" y="3900.0"/> </glyph> <glyph class="state variable" id="_68c64c41-6852-48e1-a9b6-c685749a3975"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="15056.34" y="3860.2148"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s92_wca1_wca3_sa80"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end</body> </html> Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end</body> </html> </notes> <label text="CBP*"/> <bbox w="80.0" h="40.0" x="14989.0" y="3741.75"/> <glyph class="state variable" id="_5065ba26-5a12-4775-b9d4-400da7e24f3f"> <state value="P" variable="S92"/> <bbox w="30.0" h="10.0" x="14974.492" y="3736.75"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s151_wca1_wca3_csa16" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FZD*:ROR2:WNT1_3* Identifiers_end References_begin: s_wca3_re24(MAP:survival): WNT1 induces autophosphorylation of TAK1 PMID:14960582 References_end</body> </html> </notes> <label text="FZD*:ROR2:WNT1_3*"/> <bbox w="102.0" h="152.0" x="13326.0" y="3242.0"/> <glyph class="macromolecule" id="wca1_wca3_s148_wca1_wca3_sa115"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="WNT1_3*"/> <bbox w="50.0" h="25.0" x="13354.5" y="3251.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s149_wca1_wca3_sa116"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="13336.5" y="3272.5"/> <glyph class="unit of information" id="_210f9982-6e1b-4312-a90e-d950c79c728b"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="13354.0" y="3267.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s150_wca1_wca3_sa117"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ROR2"/> <bbox w="80.0" h="50.0" x="13336.5" y="3314.5"/> <glyph class="state variable" id="_252575f7-09f2-4127-bccb-db0e7e8f88e8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13371.5" y="3359.5"/> </glyph> <glyph class="state variable" id="_1f06e8af-1436-4099-96a7-4fc51d31701d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13331.5" y="3309.5"/> </glyph> <glyph class="state variable" id="_6f4becfe-4ee4-4b4b-a33f-215f0ade0308"> <state value="" variable="S864"/> <bbox w="30.0" h="10.0" x="13401.5" y="3309.7686"/> </glyph> <glyph class="state variable" id="_439d1741-ef73-4bbc-ab37-f1f54dd30698"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13411.5" y="3359.5"/> </glyph> <glyph class="unit of information" id="_e8eaf626-80a9-446f-8bfc-4c6a33b96f4a"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="13354.0" y="3309.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s156_wca1_wca3_csa17" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NLK:TAB1:TAB2:TAK1* Identifiers_end References_begin: s_wca3_re25:(MAP:survival) PMID:20194509 s_wca3_re26:(MAP:survival) PMID:14960582 References_end</body> </html> </notes> <label text="NLK:TAB1:TAB2:TAK1*"/> <bbox w="108.0" h="218.0" x="13832.0" y="3869.0"/> <glyph class="macromolecule" id="wca1_wca3_s159_wca1_wca3_sa122"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 1 MAP3K7IP1 "mitogen-activated protein kinase kinase kinase 7 interacting protein 1" HUGO:TAB1 HGNC:18157 ENTREZ:10454 UNIPROT:Q15750 GENECARDS:TAB1 REACTOME:65612 KEGG:10454 ATLASONC:GC_TAB1 WIKI:TAB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 1 MAP3K7IP1 "mitogen-activated protein kinase kinase kinase 7 interacting protein 1" HUGO:TAB1 HGNC:18157 ENTREZ:10454 UNIPROT:Q15750 GENECARDS:TAB1 REACTOME:65612 KEGG:10454 ATLASONC:GC_TAB1 WIKI:TAB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TAB1"/> <bbox w="80.0" h="40.0" x="13845.0" y="3924.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s561_wca1_wca3_sa124"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> </notes> <label text="TAK1*"/> <bbox w="80.0" h="40.0" x="13845.0" y="3965.5"/> <glyph class="state variable" id="_dbcb4bfe-1898-4de0-9037-340272750445"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="13830.492" y="3960.5"/> </glyph> <glyph class="state variable" id="_5b5324ac-c4cd-4027-b3a8-ee66dfceffd4"> <state value="P" variable="S192"/> <bbox w="35.0" h="10.0" x="13906.882" y="4000.5"/> </glyph> <glyph class="state variable" id="_f7ed7726-53d1-4f7e-8abc-8c02b8a4a338"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13840.0" y="3980.5"/> </glyph> <glyph class="state variable" id="_d0a747b3-b02d-4a7f-91ab-e9fd00787b05"> <state value="P" variable="T184"/> <bbox w="35.0" h="10.0" x="13827.992" y="3960.5"/> </glyph> <glyph class="state variable" id="_71f67b47-9306-4790-93fe-67b8d8cfa1a7"> <state value="P" variable="T178"/> <bbox w="35.0" h="10.0" x="13827.5" y="4000.2224"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="wca1_wca3_s179_wca1_wca3_sa140"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: nemo-like kinase "nemo like kinase" HUGO:NLK HGNC:29858 ENTREZ:51701 UNIPROT:Q9UBE8 GENECARDS:NLK KEGG:2821 ATLASONC:GC_NLK WIKI:NLK Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="NLK"/> <bbox w="86.0" h="46.0" x="13844.25" y="4013.2947"/> <glyph class="unit of information" id="_2aeb6961-2399-4a5a-aeac-a3b1760bbb92"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="13877.25" y="4008.2947"/> </glyph> <glyph class="state variable" id="_f75ab22d-f600-41f0-9cb0-15391add4be0"> <state value="P" variable="T286"/> <bbox w="35.0" h="10.0" x="13912.75" y="4008.5417"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s184_wca1_wca3_sa144"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 2 MAP3K7IP2 "mitogen-activated protein kinase kinase kinase 7 interacting protein 2" HUGO:TAB2 HGNC:17075 ENTREZ:23118 UNIPROT:Q9NYJ8 GENECARDS:TAB2 REACTOME:168084 KEGG:23118 ATLASONC:GC_TAB2 WIKI:TAB2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 2 MAP3K7IP2 "mitogen-activated protein kinase kinase kinase 7 interacting protein 2" HUGO:TAB2 HGNC:17075 ENTREZ:23118 UNIPROT:Q9NYJ8 GENECARDS:TAB2 REACTOME:168084 KEGG:23118 ATLASONC:GC_TAB2 WIKI:TAB2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TAB2"/> <bbox w="80.0" h="40.0" x="13844.0" y="3880.5"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s170_wca1_wca3_csa18" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TAB1:TAK1* Identifiers_end References_begin: s_wca3_re24(MAP:survival): WNT1 induces autophosphorylation of TAK1 PMID:14960582 s_wca3_re30:(MAP:survival) PMID:20538596 s_wca3_re31(MAP:survival): Autophosphorylation sequential order: S192 T178 T187 T184 PMID:20538596 References_end</body> </html> </notes> <label text="TAB1:TAK1*"/> <bbox w="100.0" h="120.0" x="13402.0" y="3417.0"/> <glyph class="macromolecule" id="wca1_wca3_s174_wca1_wca3_sa136"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 1 MAP3K7IP1 "mitogen-activated protein kinase kinase kinase 7 interacting protein 1" HUGO:TAB1 HGNC:18157 ENTREZ:10454 UNIPROT:Q15750 GENECARDS:TAB1 REACTOME:65612 KEGG:10454 ATLASONC:GC_TAB1 WIKI:TAB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 1 MAP3K7IP1 "mitogen-activated protein kinase kinase kinase 7 interacting protein 1" HUGO:TAB1 HGNC:18157 ENTREZ:10454 UNIPROT:Q15750 GENECARDS:TAB1 REACTOME:65612 KEGG:10454 ATLASONC:GC_TAB1 WIKI:TAB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TAB1"/> <bbox w="80.0" h="40.0" x="13414.0" y="3468.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s175_wca1_wca3_sa137"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> </notes> <label text="TAK1*"/> <bbox w="80.0" h="40.0" x="13413.0" y="3426.5"/> <glyph class="state variable" id="_6ba41097-ec93-45f5-a84d-ed72ec434fa7"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="13398.492" y="3421.5"/> </glyph> <glyph class="state variable" id="_3c0f3927-30dc-4a81-bf20-dff655d83afc"> <state value="" variable="S192"/> <bbox w="30.0" h="10.0" x="13477.382" y="3461.5"/> </glyph> <glyph class="state variable" id="_ddf74de8-579f-4dae-9ac8-2cde54935a46"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13408.0" y="3441.5"/> </glyph> <glyph class="state variable" id="_688b6feb-e3bc-4ffb-a277-f0a4a473782e"> <state value="" variable="T184"/> <bbox w="30.0" h="10.0" x="13398.492" y="3421.5"/> </glyph> <glyph class="state variable" id="_9680972f-f6ba-4d78-b2ed-7c19f5ecf4c2"> <state value="" variable="T178"/> <bbox w="30.0" h="10.0" x="13398.0" y="3461.2224"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s176_wca1_wca3_csa19" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TAB1:TAK1* Identifiers_end References_begin: s_wca3_re31(MAP:survival): Autophosphorylation sequential order: S192 T178 T187 T184 PMID:20538596 References_end</body> </html> </notes> <label text="TAB1:TAK1*"/> <bbox w="100.0" h="120.0" x="13242.0" y="3417.5"/> <glyph class="macromolecule" id="wca1_wca3_s181_wca1_wca3_sa138"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 1 MAP3K7IP1 "mitogen-activated protein kinase kinase kinase 7 interacting protein 1" HUGO:TAB1 HGNC:18157 ENTREZ:10454 UNIPROT:Q15750 GENECARDS:TAB1 REACTOME:65612 KEGG:10454 ATLASONC:GC_TAB1 WIKI:TAB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 1 MAP3K7IP1 "mitogen-activated protein kinase kinase kinase 7 interacting protein 1" HUGO:TAB1 HGNC:18157 ENTREZ:10454 UNIPROT:Q15750 GENECARDS:TAB1 REACTOME:65612 KEGG:10454 ATLASONC:GC_TAB1 WIKI:TAB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TAB1"/> <bbox w="80.0" h="40.0" x="13254.0" y="3469.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s182_wca1_wca3_sa139"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> </notes> <label text="TAK1*"/> <bbox w="80.0" h="40.0" x="13253.0" y="3427.0"/> <glyph class="state variable" id="_debc3aff-b9cc-4738-bf31-90ae06208b1f"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="13238.492" y="3422.0"/> </glyph> <glyph class="state variable" id="_d652b074-a33c-4a19-8d4d-0381c0c3ecfd"> <state value="P" variable="S192"/> <bbox w="35.0" h="10.0" x="13314.882" y="3462.0"/> </glyph> <glyph class="state variable" id="_75515c6e-a3ea-4fee-8682-6144adeb75e9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13248.0" y="3442.0"/> </glyph> <glyph class="state variable" id="_c9c7d9d7-c484-4c16-8d0e-2662ddcd8b33"> <state value="P" variable="T184"/> <bbox w="35.0" h="10.0" x="13235.992" y="3422.0"/> </glyph> <glyph class="state variable" id="_03abec12-ccde-4701-b2dc-e796a1592d48"> <state value="P" variable="T178"/> <bbox w="35.0" h="10.0" x="13235.5" y="3461.7224"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s180_wca1_wca3_csa20" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TAB1:TAK1* Identifiers_end References_begin: s_wca3_re25:(MAP:survival) PMID:20194509 References_end</body> </html> </notes> <label text="TAB1:TAK1*"/> <bbox w="100.0" h="120.0" x="13652.0" y="3815.5"/> <glyph class="macromolecule" id="wca1_wca3_s177_wca1_wca3_sa141"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 1 MAP3K7IP1 "mitogen-activated protein kinase kinase kinase 7 interacting protein 1" HUGO:TAB1 HGNC:18157 ENTREZ:10454 UNIPROT:Q15750 GENECARDS:TAB1 REACTOME:65612 KEGG:10454 ATLASONC:GC_TAB1 WIKI:TAB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 1 MAP3K7IP1 "mitogen-activated protein kinase kinase kinase 7 interacting protein 1" HUGO:TAB1 HGNC:18157 ENTREZ:10454 UNIPROT:Q15750 GENECARDS:TAB1 REACTOME:65612 KEGG:10454 ATLASONC:GC_TAB1 WIKI:TAB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TAB1"/> <bbox w="80.0" h="40.0" x="13664.0" y="3867.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s178_wca1_wca3_sa142"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> </notes> <label text="TAK1*"/> <bbox w="80.0" h="40.0" x="13663.0" y="3825.0"/> <glyph class="state variable" id="_48958cfb-9c62-4876-9cb0-afb58533c267"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="13648.492" y="3820.0"/> </glyph> <glyph class="state variable" id="_81465091-92bc-44ed-b164-05660fac364f"> <state value="P" variable="S192"/> <bbox w="35.0" h="10.0" x="13724.882" y="3860.0"/> </glyph> <glyph class="state variable" id="_a624c6e8-f03f-4da6-8f99-9cb6416ca34e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13658.0" y="3840.0"/> </glyph> <glyph class="state variable" id="_24bbfc73-ddb4-4886-9d04-e2781fdc816b"> <state value="P" variable="T184"/> <bbox w="35.0" h="10.0" x="13645.992" y="3820.0"/> </glyph> <glyph class="state variable" id="_b4cc2e34-9549-479b-a499-90007d2bae6d"> <state value="P" variable="T178"/> <bbox w="35.0" h="10.0" x="13645.5" y="3859.7224"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s195_wca1_wca3_csa21" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HES1:TLE* Identifiers_end References_begin: s_wca3_re37:(MAP:survival) PMID:15367661 References_end</body> </html> </notes> <label text="HES1:TLE*"/> <bbox w="100.0" h="120.0" x="14474.0" y="3953.0"/> <glyph class="macromolecule" id="wca1_wca3_s197_wca1_wca3_sa156"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: hairy and enhancer of split 1 (Drosophila) "hairy homolog (Drosophila)" HRY HUGO:HES1 HGNC:5192 ENTREZ:3280 UNIPROT:Q14469 GENECARDS:HES1 REACTOME:56466 KEGG:3280 ATLASONC:GC_HES1 WIKI:HES1 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:FANCONI MAP:dnarepair / MODULE:TLS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HES1"/> <bbox w="80.0" h="40.0" x="14483.916" y="3964.2222"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s196_wca1_wca3_sa157"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transducin-like enhancer of split 1 (E(sp1) homolog Drosophila) "transducin-like enhancer of split 1 homolog of Drosophila E(sp1)" HUGO:TLE1 HGNC:11837 ENTREZ:7088 UNIPROT:Q04724 GENECARDS:TLE1 REACTOME:66083 KEGG:7088 ATLASONC:GC_TLE1 WIKI:TLE1 transducin-like enhancer of split 2 (E(sp1) homolog Drosophila) HUGO:TLE2 HGNC:11838 ENTREZ:7089 UNIPROT:Q04725 GENECARDS:TLE2 REACTOME:66085 KEGG:7089 WIKI:TLE2 transducin-like enhancer of split 3 (E(sp1) homolog Drosophila) HUGO:TLE3 HGNC:11839 ENTREZ:7090 UNIPROT:Q04726 GENECARDS:TLE3 REACTOME:405165 KEGG:7090 ATLASONC:GC_TLE3 WIKI:TLE3 transducin-like enhancer of split 4 (E(sp1) homolog Drosophila) HUGO:TLE4 HGNC:11840 ENTREZ:7091 UNIPROT:Q04727 GENECARDS:TLE4 REACTOME:66089 KEGG:7091 WIKI:TLE4 amino-terminal enhancer of split GRG5 TLE5 HUGO:AES HGNC:307 ENTREZ:166 UNIPROT:Q08117 GENECARDS:AES KEGG:166 ATLASONC:GC_AES WIKI:AES transducin-like enhancer of split 6 (E(sp1) homolog Drosophila) HUGO:TLE6 HGNC:30788 ENTREZ:79816 UNIPROT:Q9H808 GENECARDS:TLE6 KEGG:79816 ATLASONC:GC_TLE6 WIKI:TLE6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: References_begin non-DNA binding transcription factor PMID:20925119 References-end References_end</body> </html> </notes> <label text="TLE*"/> <bbox w="80.0" h="40.0" x="14483.916" y="4009.2222"/> <glyph class="state variable" id="_0bfa65af-b5c5-4414-b4a6-e49986e68360"> <state value="P" variable="S239"/> <bbox w="35.0" h="10.0" x="14466.908" y="4004.2222"/> </glyph> <glyph class="state variable" id="_c0c0dc00-fc11-494b-9c10-5f5958e6f514"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14558.916" y="4004.2222"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s228_wca1_wca3_csa23" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:LRP6:MI34* Identifiers_end References_begin: s_wca3_re58:(MAP:survival) PMID:22045851 References_end</body> </html> </notes> <label text="LRP6:MI34*"/> <bbox w="100.0" h="120.0" x="13383.0" y="4938.0"/> <glyph class="nucleic acid feature" id="wca1_wca3_s224_wca1_wca3_sa178"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LRP6"/> <bbox w="90.0" h="25.0" x="13390.5" y="4972.5"/> <glyph class="unit of information" id="_5f8776d1-2433-4adb-a986-35982fc356a2"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="13425.5" y="4967.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_wca3_s229_wca1_wca3_sa183"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 34a HUGO:MIR34A HGNC:31635 ENTREZ:407040 GENECARDS:MIR34A KEGG:407040 ATLASONC:GC_MIR34A WIKI:MIR34A microRNA 34b HUGO:MIR34B HGNC:31636 ENTREZ:407041 GENECARDS:MIR34B KEGG:407041 ATLASONC:GC_MIR34B WIKI:MIR34B microRNA 34c HUGO:MIR34C HGNC:31637 ENTREZ:407042 GENECARDS:MIR34C KEGG:407042 ATLASONC:GC_MIR34C WIKI:MIR34C Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Its the miR34 family depcited here References_end</body> </html> </notes> <label text="MI34*"/> <bbox w="90.0" h="25.0" x="13390.5" y="5000.0"/> <glyph class="unit of information" id="_0bb079ad-dc68-421d-ad22-132faa9f4766"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="13420.5" y="4995.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s230_wca1_wca3_csa24" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MI34*:WNT3 Identifiers_end References_begin: s_wca3_re55:(MAP:survival) PMID:22045851 References_end</body> </html> </notes> <label text="MI34*:WNT3"/> <bbox w="100.0" h="120.0" x="13504.0" y="4805.0"/> <glyph class="nucleic acid feature" id="wca1_wca3_s223_wca1_wca3_sa177"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: wingless-type MMTV integration site family member 3 INT4 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="WNT3"/> <bbox w="90.0" h="25.0" x="13509.0" y="4831.5"/> <glyph class="unit of information" id="_dfdf1fed-2554-4cae-b419-67991b25c0a6"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="13544.0" y="4826.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_wca3_s231_wca1_wca3_sa182"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 34a HUGO:MIR34A HGNC:31635 ENTREZ:407040 GENECARDS:MIR34A KEGG:407040 ATLASONC:GC_MIR34A WIKI:MIR34A microRNA 34b HUGO:MIR34B HGNC:31636 ENTREZ:407041 GENECARDS:MIR34B KEGG:407041 ATLASONC:GC_MIR34B WIKI:MIR34B microRNA 34c HUGO:MIR34C HGNC:31637 ENTREZ:407042 GENECARDS:MIR34C KEGG:407042 ATLASONC:GC_MIR34C WIKI:MIR34C Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Its the miR34 family depcited here References_end</body> </html> </notes> <label text="MI34*"/> <bbox w="90.0" h="25.0" x="13509.0" y="4858.0"/> <glyph class="unit of information" id="_ae35b58b-8305-413d-b773-52e01698c6c1"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="13539.0" y="4853.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s232_wca1_wca3_csa25" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MI34*:WNT1 Identifiers_end References_begin: s_wca3_re52:(MAP:survival) PMID:22045851 References_end</body> </html> </notes> <label text="MI34*:WNT1"/> <bbox w="100.0" h="120.0" x="13505.0" y="4664.0"/> <glyph class="nucleic acid feature" id="wca1_wca3_s233_wca1_wca3_sa175"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 34a HUGO:MIR34A HGNC:31635 ENTREZ:407040 GENECARDS:MIR34A KEGG:407040 ATLASONC:GC_MIR34A WIKI:MIR34A microRNA 34b HUGO:MIR34B HGNC:31636 ENTREZ:407041 GENECARDS:MIR34B KEGG:407041 ATLASONC:GC_MIR34B WIKI:MIR34B microRNA 34c HUGO:MIR34C HGNC:31637 ENTREZ:407042 GENECARDS:MIR34C KEGG:407042 ATLASONC:GC_MIR34C WIKI:MIR34C Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Its the miR34 family depcited here References_end</body> </html> </notes> <label text="MI34*"/> <bbox w="90.0" h="25.0" x="13509.5" y="4727.5"/> <glyph class="unit of information" id="_5839f56c-8a36-4d25-a17b-2446d6322012"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="13539.5" y="4722.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_wca3_s222_wca1_wca3_sa176"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 INT1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="WNT1"/> <bbox w="90.0" h="25.0" x="13509.5" y="4699.5"/> <glyph class="unit of information" id="_d7be0d1d-7675-49c6-bcc8-664738b7ab99"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="13544.5" y="4694.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s234_wca1_wca3_csa26" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:LEF1:MI34* Identifiers_end References_begin: s_wca3_re49:(MAP:survival) PMID:22045851 References_end</body> </html> </notes> <label text="LEF1:MI34*"/> <bbox w="100.0" h="120.0" x="13383.0" y="4664.0"/> <glyph class="nucleic acid feature" id="wca1_wca3_s226_wca1_wca3_sa180"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LEF1"/> <bbox w="90.0" h="25.0" x="13389.0" y="4700.5"/> <glyph class="unit of information" id="_0af7c6bb-afc0-4579-ad80-10ab9ead75b7"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="13424.0" y="4695.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_wca3_s235_wca1_wca3_sa181"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 34a HUGO:MIR34A HGNC:31635 ENTREZ:407040 GENECARDS:MIR34A KEGG:407040 ATLASONC:GC_MIR34A WIKI:MIR34A microRNA 34b HUGO:MIR34B HGNC:31636 ENTREZ:407041 GENECARDS:MIR34B KEGG:407041 ATLASONC:GC_MIR34B WIKI:MIR34B microRNA 34c HUGO:MIR34C HGNC:31637 ENTREZ:407042 GENECARDS:MIR34C KEGG:407042 ATLASONC:GC_MIR34C WIKI:MIR34C Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Its the miR34 family depcited here References_end</body> </html> </notes> <label text="MI34*"/> <bbox w="90.0" h="25.0" x="13389.0" y="4727.0"/> <glyph class="unit of information" id="_664eb836-6ab8-4eef-83c9-b75a6175bf3d"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="13419.0" y="4722.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s236_wca1_wca3_csa27" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MI34*:_beta_-Catenin* Identifiers_end References_begin: s_wca3_re61:(MAP:survival) PMID:22045851 References_end</body> </html> </notes> <label text="MI34*:β-Catenin*"/> <bbox w="100.0" h="120.0" x="13383.0" y="4803.0"/> <glyph class="nucleic acid feature" id="wca1_wca3_s225_wca1_wca3_sa179"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 ; ; ; Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 ; ; ; Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="90.0" h="25.0" x="13389.0" y="4831.5"/> <glyph class="unit of information" id="_db826f1e-350e-443e-b905-abfea2558d4d"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="13424.0" y="4826.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_wca3_s221_wca1_wca3_sa184"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 34a HUGO:MIR34A HGNC:31635 ENTREZ:407040 GENECARDS:MIR34A KEGG:407040 ATLASONC:GC_MIR34A WIKI:MIR34A microRNA 34b HUGO:MIR34B HGNC:31636 ENTREZ:407041 GENECARDS:MIR34B KEGG:407041 ATLASONC:GC_MIR34B WIKI:MIR34B microRNA 34c HUGO:MIR34C HGNC:31637 ENTREZ:407042 GENECARDS:MIR34C KEGG:407042 ATLASONC:GC_MIR34C WIKI:MIR34C Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Its the miR34 family depcited here References_end</body> </html> </notes> <label text="MI34*"/> <bbox w="90.0" h="25.0" x="13389.0" y="4857.0"/> <glyph class="unit of information" id="_9a6acaf5-c9db-4ba2-8fa6-85ccbf21cd90"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="13419.0" y="4852.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s257_wca1_wca3_csa28" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL9:PYGO*:SMAD1:TCF4:_beta_-Catenin*:p300* Identifiers_end References_begin: NOTE: In the original article (PMID:15576399)is unknown if p300/PYGO/bcl9 and wich PTMs on b-catenin are present in this complex. Based on canonical transcription by b-catenin the afore mentioned proteins are required for activating gene transcription. s_wca3_re64(MAP:survival): Under pathological conditions this complex will be formed. This complex has synergistic positive effect on myc gene expression. PMID:15576399 s_wca3_re65(MAP:survival): PMID:22761862 Smad1 alone inhibits myc expression while b-catenin/TCF4 activates gene expression. Highest gene expression obtained when SMAD1/b-catenin/TCF4 complex is formed Mi-2/NuRD PMID:22290435 References_end</body> </html> </notes> <label text="BCL9:PYGO*:SMAD1:TCF4:β-Catenin*:p300*"/> <bbox w="223.0" h="176.0" x="14701.75" y="4039.0"/> <glyph class="macromolecule" id="wca1_wca3_s250_wca1_wca3_sa197"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: B-cell CLL/lymphoma 9 HUGO:BCL9 HGNC:1008 ENTREZ:607 UNIPROT:O00512 GENECARDS:BCL9 KEGG:607 ATLASONC:BCL9ID466 WIKI:BCL9 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BCL9"/> <bbox w="80.0" h="40.0" x="14722.3125" y="4135.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s251_wca1_wca3_sa198"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: pygopus homolog 1 (Drosophila) HUGO:PYGO1 HGNC:30256 ENTREZ:26108 UNIPROT:Q9Y3Y4 GENECARDS:PYGO1 WIKI:PYGO1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PYGO*"/> <bbox w="80.0" h="40.0" x="14722.3125" y="4094.125"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s252_wca1_wca3_sa199"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="14816.5625" y="4053.0"/> <glyph class="state variable" id="_a7ec2552-9b72-4497-b14a-ec8f075d17f3"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="14843.967" y="4088.0"/> </glyph> <glyph class="state variable" id="_8fe43445-ad3d-4518-8f7a-4c568c614e0e"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="14883.444" y="4088.0"/> </glyph> <glyph class="state variable" id="_52192e53-e102-4501-b054-4646f4a22e54"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="14884.0625" y="4048.2148"/> </glyph> <glyph class="state variable" id="_0dafa061-f77d-4f4e-bab1-02a92a1aa365"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="14844.095" y="4048.0"/> </glyph> <glyph class="state variable" id="_9f437d8d-bd2f-4b64-8841-ce378ebbf2e6"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="14804.555" y="4048.0"/> </glyph> <glyph class="state variable" id="_a3b2883e-573f-4196-955b-217bd38872fc"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="14804.0625" y="4087.7224"/> </glyph> <glyph class="state variable" id="_6891c4a9-f348-441b-91d3-006f2fa1cb8a"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="14881.5625" y="4048.2148"/> </glyph> <glyph class="state variable" id="_06e522ff-fbea-4ec7-a499-2f9dafcbcebe"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="14881.5625" y="4048.2148"/> </glyph> <glyph class="state variable" id="_1b8f6897-1417-476c-8934-be1f88df140f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14811.5625" y="4068.0"/> </glyph> <glyph class="state variable" id="_8cb199f8-3e2f-4994-ae9f-92c8a51d22f3"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="14802.055" y="4048.0"/> </glyph> <glyph class="state variable" id="_b0b6db2f-6fd8-48b9-9dc0-bd73d544bcb4"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="14881.5625" y="4048.2148"/> </glyph> <glyph class="state variable" id="_b60e9ee3-6826-4b02-bd8d-21a0d9dfc6ca"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14811.5625" y="4059.7158"/> </glyph> <glyph class="state variable" id="_633ee4f2-17a6-4b49-ab32-d28b27090761"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="14881.5625" y="4048.2148"/> </glyph> <glyph class="state variable" id="_5b516427-26a7-4d5d-9575-c97b4b3c4833"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14811.5625" y="4068.0"/> </glyph> <glyph class="state variable" id="_9933ea1e-cc12-4510-bd5e-b6e92f6bb2d0"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="14880.944" y="4088.0"/> </glyph> <glyph class="state variable" id="_423a1fae-dbd1-4538-a773-0f245bcff557"> <state value="Ac" variable="K345"/> <bbox w="40.0" h="10.0" x="14876.5625" y="4048.2148"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s254_wca1_wca3_sa202"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: E1A binding protein p300 HUGO:EP300 HGNC:3373 ENTREZ:2033 UNIPROT:Q09472 GENECARDS:EP300 REACTOME:61164 KEGG:2033 ATLASONC:P300ID97 WIKI:EP300 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:HIF1 MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="p300*"/> <bbox w="80.0" h="40.0" x="14722.125" y="4053.25"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s255_wca1_wca3_sa203"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TCF4"/> <bbox w="80.0" h="40.0" x="14816.0" y="4094.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s261_wca1_wca3_sa204"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: SMAD family member 1 "MAD mothers against decapentaplegic homolog 1 (Drosophila)" MADH1 "SMAD mothers against DPP homolog 1 (Drosophila)" HUGO:SMAD1 HGNC:6767 ENTREZ:4086 UNIPROT:Q15797 GENECARDS:SMAD1 REACTOME:64616 KEGG:4086 ATLASONC:GC_SMAD1 WIKI:SMAD1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="SMAD1"/> <bbox w="80.0" h="40.0" x="14817.0" y="4134.5"/> <glyph class="state variable" id="_8372dade-00dd-4e13-8bcd-9b0b197ac1e7"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14889.5" y="4129.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s263_wca1_wca3_csa29" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NICD*:_beta_-Catenin* Identifiers_end References_begin: s_wca3_re67:(MAP:survival) PMID:19000719 s_wca3_re69(MAP:survival): Synergistic effect on HES1 transcription PMID:19000719 References_end</body> </html> </notes> <label text="NICD*:β-Catenin*"/> <bbox w="100.0" h="120.0" x="14471.0" y="3628.0"/> <glyph class="macromolecule" id="wca1_wca3_s265_wca1_wca3_sa209"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: notch 1 HUGO:NOTCH1 HGNC:7881 ENTREZ:4851 UNIPROT:P46531 GENECARDS:NOTCH1 REACTOME:60520 KEGG:4851 ATLASONC:NOTCH1ID30ch9q34 WIKI:NOTCH1 notch 2 HUGO:NOTCH2 HGNC:7882 ENTREZ:4853 UNIPROT:Q04721 GENECARDS:NOTCH2 REACTOME:60522 KEGG:4853 ATLASONC:NOTCH2ID41556ch1p12 WIKI:NOTCH2 notch 3 HUGO:NOTCH3 HGNC:7883 ENTREZ:4854 UNIPROT:Q9UM47 GENECARDS:NOTCH3 REACTOME:60524 KEGG:4854 ATLASONC:NOTCH3ID41557ch19p13 WIKI:NOTCH3 notch 4 HUGO:NOTCH4 HGNC:7884 ENTREZ:4855 UNIPROT:Q99466 GENECARDS:NOTCH4 REACTOME:60526 KEGG:4855 ATLASONC:GC_NOTCH4 WIKI:NOTCH4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="NICD*"/> <bbox w="80.0" h="40.0" x="14482.0" y="3683.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s264_wca1_wca3_sa210"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="14482.0" y="3641.5"/> <glyph class="state variable" id="_a66bd349-1dba-434f-97c4-67139c1f6820"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="14509.404" y="3676.5"/> </glyph> <glyph class="state variable" id="_587255ca-7675-492f-9606-d89e96a95d6f"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="14548.882" y="3676.5"/> </glyph> <glyph class="state variable" id="_b7a1b51a-fe33-4215-9682-1d1a341d39d7"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="14549.5" y="3636.7148"/> </glyph> <glyph class="state variable" id="_1e792587-9077-4bc4-9c05-7a0d9f4bfc5b"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="14509.532" y="3636.5"/> </glyph> <glyph class="state variable" id="_db21d047-97f3-4882-97c8-68e7c8b31840"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="14469.992" y="3636.5"/> </glyph> <glyph class="state variable" id="_7eeee551-7815-4597-8ac2-d28683dfdba6"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="14469.5" y="3676.2224"/> </glyph> <glyph class="state variable" id="_077aa16d-92ee-437e-b569-7e76121bad52"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="14547.0" y="3636.7148"/> </glyph> <glyph class="state variable" id="_94ec7fbd-8adf-4d06-a89a-8fa02a987b4c"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="14547.0" y="3636.7148"/> </glyph> <glyph class="state variable" id="_f66cc159-8163-4f55-ae89-4cce6215465d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14477.0" y="3656.5"/> </glyph> <glyph class="state variable" id="_5ed86011-8171-439e-91b2-496eb34ccd51"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="14467.492" y="3636.5"/> </glyph> <glyph class="state variable" id="_304439bf-ba1b-428b-9fb9-4eb8ec8709fb"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="14547.0" y="3636.7148"/> </glyph> <glyph class="state variable" id="_6d152f81-c6b7-48c5-8bd9-ccb83a6b239b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14477.0" y="3648.2158"/> </glyph> <glyph class="state variable" id="_ebdad70d-ce11-43e2-99b2-eb81496b8516"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="14547.0" y="3636.7148"/> </glyph> <glyph class="state variable" id="_9d39647e-1925-495c-9e87-a17143cec20a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14477.0" y="3656.5"/> </glyph> <glyph class="state variable" id="_04a8a5ad-7848-48b4-abad-7321e7666627"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="14546.382" y="3676.5"/> </glyph> <glyph class="state variable" id="_6c523787-0094-4939-b134-624dbeed4694"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="14547.0" y="3636.7148"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s270_wca1_wca3_csa30" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NFKB1_p50*:RELA Identifiers_end References_begin: s_wca3_re73:(MAP:survival) PMID:19383900 References_end</body> </html> </notes> <label text="NFKB1_p50*:RELA"/> <bbox w="100.0" h="120.0" x="14628.0" y="3626.0"/> <glyph class="macromolecule" id="wca1_wca3_s268_wca1_wca3_sa213"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: v-rel reticuloendotheliosis viral oncogene homolog A (avian) NFKB3 "nuclear factor of kappa light polypeptide gene enhancer in B-cells 3" HUGO:RELA HGNC:9955 ENTREZ:5970 UNIPROT:Q04206 GENECARDS:RELA REACTOME:65897 KEGG:5970 ATLASONC:RELAID325 WIKI:RELA Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RELA"/> <bbox w="80.0" h="40.0" x="14637.0" y="3636.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s269_wca1_wca3_sa214"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 HUGO:NFKB1 HGNC:7794 ENTREZ:4790 UNIPROT:P19838 GENECARDS:NFKB1 REACTOME:57855 KEGG:4790 ATLASONC:NFKB1ID323 WIKI:NFKB1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="NFKB1_p50*"/> <bbox w="80.0" h="40.0" x="14637.0" y="3678.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s281_wca1_wca3_csa31" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:NFKB1_p50*:RELA:_beta_-Catenin* Identifiers_end References_begin: s_wca3_re73:(MAP:survival) PMID:19383900 References_end</body> </html> </notes> <label text="NFKB1_p50*:RELA:β-Catenin*"/> <bbox w="101.0" h="164.0" x="14802.0" y="3831.5"/> <glyph class="macromolecule" id="wca1_wca3_s279_wca1_wca3_sa218"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: v-rel reticuloendotheliosis viral oncogene homolog A (avian) NFKB3 "nuclear factor of kappa light polypeptide gene enhancer in B-cells 3" HUGO:RELA HGNC:9955 ENTREZ:5970 UNIPROT:Q04206 GENECARDS:RELA REACTOME:65897 KEGG:5970 ATLASONC:RELAID325 WIKI:RELA Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RELA"/> <bbox w="80.0" h="40.0" x="14811.0" y="3841.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s280_wca1_wca3_sa219"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 HUGO:NFKB1 HGNC:7794 ENTREZ:4790 UNIPROT:P19838 GENECARDS:NFKB1 REACTOME:57855 KEGG:4790 ATLASONC:NFKB1ID323 WIKI:NFKB1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="NFKB1_p50*"/> <bbox w="80.0" h="40.0" x="14811.0" y="3883.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s277_wca1_wca3_sa220"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="14810.0" y="3926.5"/> <glyph class="state variable" id="_f0c06ece-d94f-403a-8729-73f9e3fb194b"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="14837.404" y="3961.5"/> </glyph> <glyph class="state variable" id="_346e9073-17ac-43b3-bba1-1afc7bfbae7d"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="14876.882" y="3961.5"/> </glyph> <glyph class="state variable" id="_af56903c-78b9-4d1d-aea7-60ba7a34e16c"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="14877.5" y="3921.7148"/> </glyph> <glyph class="state variable" id="_503fe091-23f3-4603-96db-8d97d80e490b"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="14837.532" y="3921.5"/> </glyph> <glyph class="state variable" id="_59334213-7977-4381-96d8-3b288e0c5f4c"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="14797.992" y="3921.5"/> </glyph> <glyph class="state variable" id="_c850cd20-eae3-41f4-8836-334971a1a4fa"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="14797.5" y="3961.2224"/> </glyph> <glyph class="state variable" id="_06f65104-9ebe-43bc-bd71-d7d663cd220b"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="14875.0" y="3921.7148"/> </glyph> <glyph class="state variable" id="_55d1efbb-612c-42b2-b44a-1cedfcea09b2"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="14875.0" y="3921.7148"/> </glyph> <glyph class="state variable" id="_4ab27472-2214-4a36-bb45-56978295c18c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14805.0" y="3941.5"/> </glyph> <glyph class="state variable" id="_af17b38b-ea74-42bd-883d-4fae62cf02be"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="14795.492" y="3921.5"/> </glyph> <glyph class="state variable" id="_9fc5930f-6b12-4629-8208-f1ab4ea17db6"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="14875.0" y="3921.7148"/> </glyph> <glyph class="state variable" id="_012547f6-e163-4627-b964-6690edc8ea3f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14805.0" y="3933.2158"/> </glyph> <glyph class="state variable" id="_565b3178-8aa5-4e14-a68d-b235b5a7f134"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="14875.0" y="3921.7148"/> </glyph> <glyph class="state variable" id="_4d27a320-22aa-4bb0-8560-c11f5db5bea3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14805.0" y="3941.5"/> </glyph> <glyph class="state variable" id="_eee7be5c-346d-483e-9586-efba3665c0e5"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="14874.382" y="3961.5"/> </glyph> <glyph class="state variable" id="_8c8c3318-c1fe-48b1-a5d6-95d776ca9fca"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="14875.0" y="3921.7148"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s314_wca1_wca3_csa34" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC:_beta_-Catenin* Identifiers_end References_begin: s_wca3_re88:(MAP:survival) PMID:10984057 PMID:11263497 s_wca3_re86:(MAP:survival) PMID:10980707 PMID:12606575 References_end</body> </html> </notes> <label text="APC:β-Catenin*"/> <bbox w="100.0" h="120.0" x="13230.0" y="4034.0"/> <glyph class="macromolecule" id="wca1_wca3_s316_wca1_wca3_sa242"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="13241.75" y="4041.0"/> <glyph class="state variable" id="_752846b2-6824-4316-908f-1c59a3b000f4"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="13303.632" y="4076.0"/> </glyph> <glyph class="state variable" id="_62aac4f1-65f5-4fd0-8eae-679b0f63cb71"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="13224.742" y="4036.0"/> </glyph> <glyph class="state variable" id="_3a677e56-d87b-4f45-82fd-6482224a9259"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="13304.25" y="4036.2148"/> </glyph> <glyph class="state variable" id="_deac5a30-0b3f-43ff-b244-22795ebbe0d0"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="13264.154" y="4076.0"/> </glyph> <glyph class="state variable" id="_3f1eb121-5e40-4ccf-aab7-5a3475f467fb"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="13264.282" y="4036.0"/> </glyph> <glyph class="state variable" id="_d57b1a9a-c953-449b-9c34-c890f9d99c00"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="13224.25" y="4075.7224"/> </glyph> <glyph class="state variable" id="_03727d26-3b46-4471-8527-57c79847edf3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13316.75" y="4036.0"/> </glyph> <glyph class="state variable" id="_cce3bb3c-27b9-4bed-94b9-706a1e4c1e78"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="13304.25" y="4075.1306"/> </glyph> <glyph class="state variable" id="_c0f0fae8-b518-406b-8819-4e78c32d8d87"> <state value="P" variable="S2034"/> <bbox w="40.0" h="10.0" x="13221.75" y="4075.7224"/> </glyph> <glyph class="state variable" id="_77f333ab-b1bb-4652-83e9-4b2e2ef0cd2b"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13229.742" y="4036.0"/> </glyph> <glyph class="state variable" id="_97b568b3-389f-4883-a276-ff20bf169cbc"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="13224.742" y="4036.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s315_wca1_wca3_sa243"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="13241.75" y="4086.0"/> <glyph class="state variable" id="_f8249586-7588-40d0-9df1-06ddb22e91a9"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="13269.154" y="4121.0"/> </glyph> <glyph class="state variable" id="_0c9640ea-5405-462a-8102-cf3a1d8c96a8"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="13308.632" y="4121.0"/> </glyph> <glyph class="state variable" id="_28f83c70-9a1f-448d-b550-e90271b6474e"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="13309.25" y="4081.2148"/> </glyph> <glyph class="state variable" id="_93258914-bc83-4887-81fd-1b6b88039a8a"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="13269.282" y="4081.0"/> </glyph> <glyph class="state variable" id="_c516d6ea-8f7a-4167-a51d-d04e31e64bd8"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="13229.742" y="4081.0"/> </glyph> <glyph class="state variable" id="_c5ae06be-410a-435c-99d8-a3da037e60a5"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="13229.25" y="4120.722"/> </glyph> <glyph class="state variable" id="_4885a38b-84e4-42e2-ab41-9766688475f5"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="13306.75" y="4081.2148"/> </glyph> <glyph class="state variable" id="_6ed094c1-bbff-4ba4-b1bd-ea1775bb79d9"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="13306.75" y="4081.2148"/> </glyph> <glyph class="state variable" id="_bdc35253-16b5-48a4-abff-698990a07b3f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13236.75" y="4101.0"/> </glyph> <glyph class="state variable" id="_3a9da8cf-3640-45d1-8e68-0a51d28dcb6f"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="13227.242" y="4081.0"/> </glyph> <glyph class="state variable" id="_c04fe4d4-9eb3-4c6e-9880-7fddfe02d955"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="13306.75" y="4081.2148"/> </glyph> <glyph class="state variable" id="_57ec9ab0-3ce1-44a6-aa0a-c4e243a1a567"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13236.75" y="4092.7158"/> </glyph> <glyph class="state variable" id="_17d03e37-0afd-40cd-8b5d-a6eaef79eb12"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="13306.75" y="4081.2148"/> </glyph> <glyph class="state variable" id="_729a470e-0872-4809-b726-54b9133502d2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13236.75" y="4101.0"/> </glyph> <glyph class="state variable" id="_9cc7db04-0934-474f-af32-3693c0cf3307"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="13306.132" y="4121.0"/> </glyph> <glyph class="state variable" id="_d7d08db2-cdda-4543-93c7-2477c70d45e0"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="13306.75" y="4081.2148"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s317_wca1_wca3_csa35" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC:_beta_-Catenin* Identifiers_end References_begin: s_wca3_re89:(MAP:survival) PMID:10984057 PMID:11263497 s_wca3_re87:(MAP:survival) PMID:10980707 PMID:12606575 References_end</body> </html> </notes> <label text="APC:β-Catenin*"/> <bbox w="100.0" h="120.0" x="13250.0" y="4170.0"/> <glyph class="macromolecule" id="wca1_wca3_s319_wca1_wca3_sa244"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="13260.75" y="4179.0"/> <glyph class="state variable" id="_de5d0c95-163e-4a41-b9b8-3b50414ba67b"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="13288.154" y="4214.0"/> </glyph> <glyph class="state variable" id="_45021c18-ae34-4cc4-9cb4-ffe80561f3e0"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="13327.632" y="4214.0"/> </glyph> <glyph class="state variable" id="_3bcc50fb-a376-4575-a1f0-b07bd25bdf14"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="13328.25" y="4174.215"/> </glyph> <glyph class="state variable" id="_9191e075-30e7-4e17-bc13-fe7497c0ec38"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="13288.282" y="4174.0"/> </glyph> <glyph class="state variable" id="_e0e2a935-e94c-4fcb-ad70-fc18e0f7f208"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="13248.742" y="4174.0"/> </glyph> <glyph class="state variable" id="_7568bd4c-57ef-486d-b011-6dbf1a03cdf2"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="13248.25" y="4213.722"/> </glyph> <glyph class="state variable" id="_b937dd57-0432-47fa-99f1-cb120dc32454"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="13325.75" y="4174.215"/> </glyph> <glyph class="state variable" id="_b2c41192-e2f3-4e33-8859-9b228e6a3c19"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="13325.75" y="4174.215"/> </glyph> <glyph class="state variable" id="_e9efd573-1517-4e42-9cca-c000a450298c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13255.75" y="4194.0"/> </glyph> <glyph class="state variable" id="_26c7c163-0932-4971-b8b1-c8ab7632987e"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="13246.242" y="4174.0"/> </glyph> <glyph class="state variable" id="_673e1a8d-2895-474f-b110-ea05b6d8d06d"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="13325.75" y="4174.215"/> </glyph> <glyph class="state variable" id="_5f9a5e9a-2bbb-4f31-87b1-e0adb735e0f4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13255.75" y="4185.716"/> </glyph> <glyph class="state variable" id="_60ac78c5-f0fb-4e63-93c2-830ce0353bcb"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="13325.75" y="4174.215"/> </glyph> <glyph class="state variable" id="_3266f2a0-81fb-414d-8977-ea6cda86e6b3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13255.75" y="4194.0"/> </glyph> <glyph class="state variable" id="_fabd464f-ebab-4bfd-9708-e1cd5084acca"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="13325.132" y="4214.0"/> </glyph> <glyph class="state variable" id="_dcc821c0-5b15-4585-b144-fc75fb2bd46d"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="13325.75" y="4174.215"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s318_wca1_wca3_sa245"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="13260.75" y="4223.0"/> <glyph class="state variable" id="_4ad86561-9aa3-4470-8bef-717cda3ec348"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="13322.632" y="4258.0"/> </glyph> <glyph class="state variable" id="_d89adc74-47c9-4636-a015-ba6ca3dda6da"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="13243.742" y="4218.0"/> </glyph> <glyph class="state variable" id="_99a2420f-8d47-4a0b-af5d-82552a285a81"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="13323.25" y="4218.215"/> </glyph> <glyph class="state variable" id="_820fd2d7-903e-4e6c-a5a1-0c202e247abc"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="13283.154" y="4258.0"/> </glyph> <glyph class="state variable" id="_d0b6c860-8760-4c1b-a50a-3b194834c1f8"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="13283.282" y="4218.0"/> </glyph> <glyph class="state variable" id="_307744c5-2b39-40f4-8d85-890d48ac3b4a"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="13243.25" y="4257.722"/> </glyph> <glyph class="state variable" id="_e2d94df2-53b7-4469-be47-08de1d71eee0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13335.75" y="4218.0"/> </glyph> <glyph class="state variable" id="_eb6015bd-2866-4ba0-87b4-1f95cd8b1e6a"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="13323.25" y="4257.131"/> </glyph> <glyph class="state variable" id="_c1feb139-4a55-4d52-b983-5b929a113bfa"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="13243.25" y="4257.722"/> </glyph> <glyph class="state variable" id="_05deea16-ce4f-4fe0-a70f-d94f5dfeeb2f"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13248.742" y="4218.0"/> </glyph> <glyph class="state variable" id="_679f4eb5-d31d-46df-8cee-7bacedd68da8"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="13243.742" y="4218.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s323_wca1_wca3_csa37" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC:_beta_-Catenin* Identifiers_end References_begin: s_wca3_re87:(MAP:survival) PMID:10980707 PMID:12606575 References_end</body> </html> </notes> <label text="APC:β-Catenin*"/> <bbox w="100.0" h="120.0" x="12892.0" y="4170.0"/> <glyph class="macromolecule" id="wca1_wca3_s324_wca1_wca3_sa248"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="12902.75" y="4179.0"/> <glyph class="state variable" id="_07961c38-884a-4b8e-acb9-5fcc79800b4c"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="12930.154" y="4214.0"/> </glyph> <glyph class="state variable" id="_de3f8f4f-882c-43b2-bbe2-8b5acd2989ee"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="12969.632" y="4214.0"/> </glyph> <glyph class="state variable" id="_84e74c49-1f33-4f04-8424-d59135df9284"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="12970.25" y="4174.215"/> </glyph> <glyph class="state variable" id="_33441816-097d-4ceb-83d2-80af28787de6"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="12930.282" y="4174.0"/> </glyph> <glyph class="state variable" id="_4c64c543-6ecd-4df6-8c1e-bcc5d061b732"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="12890.742" y="4174.0"/> </glyph> <glyph class="state variable" id="_13d87a4c-6c0e-47a3-a6c8-9cdead7998a4"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="12890.25" y="4213.722"/> </glyph> <glyph class="state variable" id="_c385cea1-8ee4-4944-918b-2bdcb5dd8aba"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="12967.75" y="4174.215"/> </glyph> <glyph class="state variable" id="_0a38c6dc-8056-44b1-b47c-ced9002c17d1"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="12967.75" y="4174.215"/> </glyph> <glyph class="state variable" id="_ccd5d456-a651-46ba-bd09-dd1ed44dfe48"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12897.75" y="4194.0"/> </glyph> <glyph class="state variable" id="_98e40eed-4e4b-4d48-bffd-61538866dbe9"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="12888.242" y="4174.0"/> </glyph> <glyph class="state variable" id="_a808e69e-2406-471a-93a8-4eb75e68bf19"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="12967.75" y="4174.215"/> </glyph> <glyph class="state variable" id="_61a87f18-da8c-4619-b9b9-3487d64d7063"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12897.75" y="4185.716"/> </glyph> <glyph class="state variable" id="_4a1dc3f4-81e0-47be-8886-f474e322398a"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="12967.75" y="4174.215"/> </glyph> <glyph class="state variable" id="_80241d24-6d05-4b2a-ae55-a437caf2237b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12897.75" y="4194.0"/> </glyph> <glyph class="state variable" id="_fae292db-9832-4d01-8b3d-279cc552d840"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="12967.132" y="4214.0"/> </glyph> <glyph class="state variable" id="_d1d5ffff-a40f-43d6-8d0b-1aae1b895360"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="12967.75" y="4174.215"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s325_wca1_wca3_sa249"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="12902.75" y="4223.0"/> <glyph class="state variable" id="_5286b461-578d-4d7e-bb00-e8b1044b7b96"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="12964.632" y="4258.0"/> </glyph> <glyph class="state variable" id="_7aed8f00-7693-4802-b162-88a6825bc737"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="12885.742" y="4218.0"/> </glyph> <glyph class="state variable" id="_5829dca1-c4b9-4475-8a6e-96ec2bd426e7"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="12965.25" y="4218.215"/> </glyph> <glyph class="state variable" id="_60b9a32e-ffd9-4f86-b0eb-b54fc8208486"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="12925.154" y="4258.0"/> </glyph> <glyph class="state variable" id="_1d937d27-fbdd-49a4-8824-3b8e4003c4cb"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="12925.282" y="4218.0"/> </glyph> <glyph class="state variable" id="_3ec8a30c-d561-4866-94d3-9527842a33b0"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="12885.25" y="4257.722"/> </glyph> <glyph class="state variable" id="_a88f4e3e-b66f-45fd-a350-8a6c86cf9a11"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12977.75" y="4218.0"/> </glyph> <glyph class="state variable" id="_3644d7fc-8ffb-42e3-8844-1b35a9fec22c"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="12965.25" y="4257.131"/> </glyph> <glyph class="state variable" id="_b206507b-337f-46a1-ae60-7229b3d720d1"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="12885.25" y="4257.722"/> </glyph> <glyph class="state variable" id="_191740e9-21f0-435b-a9cd-5c3d3323794d"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12890.742" y="4218.0"/> </glyph> <glyph class="state variable" id="_97b22a90-dab1-46be-b096-3582ffc6e594"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="12885.742" y="4218.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s328_wca1_wca3_csa38" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC:B56_alpha_* Identifiers_end References_begin: s_wca3_re90:(MAP:survival) PMID:11585828 s_wca3_re83(MAP:survival): Import of APC does not require phosphorylation of APC PMID:12223464 References_end</body> </html> </notes> <label text="APC:B56α*"/> <bbox w="100.0" h="120.0" x="13023.0" y="3588.0"/> <glyph class="macromolecule" id="wca1_wca3_s330_wca1_wca3_sa251"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="13032.75" y="3599.0"/> <glyph class="state variable" id="_ccb98a9e-1543-4901-9d32-0d7392655698"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="13094.632" y="3634.0"/> </glyph> <glyph class="state variable" id="_8455146d-8b48-493b-b320-ad55bca32363"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="13015.742" y="3594.0"/> </glyph> <glyph class="state variable" id="_510904db-b126-4179-8c0a-f0a6aed8874b"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="13095.25" y="3594.2148"/> </glyph> <glyph class="state variable" id="_e594c359-280f-4cb4-8196-f898bff89c9e"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="13055.154" y="3634.0"/> </glyph> <glyph class="state variable" id="_a070f96a-ccdd-443e-b176-4bbfbeabbee8"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="13055.282" y="3594.0"/> </glyph> <glyph class="state variable" id="_3a5d1798-816e-4df0-b12a-fe0fe9b84736"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="13015.25" y="3633.7224"/> </glyph> <glyph class="state variable" id="_fac60f20-2d52-4d7a-8eb2-ae87ceffcc8d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13107.75" y="3594.0"/> </glyph> <glyph class="state variable" id="_9d5758f7-e682-4aef-a738-5daae75bdc0d"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="13095.25" y="3633.1306"/> </glyph> <glyph class="state variable" id="_c30cba9e-5d0a-4f8a-b3fa-ee4d325fc0df"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="13015.25" y="3633.7224"/> </glyph> <glyph class="state variable" id="_88ffa8c6-0ec4-4d39-abe0-b0041585eb69"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13020.742" y="3594.0"/> </glyph> <glyph class="state variable" id="_590606bd-6620-40c8-bdda-49ffe7e7858e"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="13015.742" y="3594.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s329_wca1_wca3_sa252"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 2 regulatory subunit B' alpha HUGO:PPP2R5A HGNC:9309 ENTREZ:5525 UNIPROT:Q15172 GENECARDS:PPP2R5A REACTOME:49115 KEGG:5525 ATLASONC:GC_PPP2R5A WIKI:PPP2R5A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="B56α*"/> <bbox w="80.0" h="40.0" x="13032.75" y="3643.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s332_wca1_wca3_csa39" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC:B56_alpha_* Identifiers_end References_begin: s_wca3_re91:(MAP:survival) PMID:11585828 s_wca3_re79(MAP:survival): This transport is enhanced upon phosphorylation however it is not necessary for import of APC into nucleus PMID:11689703 PMID:15649893 PMID:11050185 PMID:12223464 References_end</body> </html> </notes> <label text="APC:B56α*"/> <bbox w="100.0" h="120.0" x="13027.0" y="3769.0"/> <glyph class="macromolecule" id="wca1_wca3_s340_wca1_wca3_sa253"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="13039.0" y="3780.0"/> <glyph class="state variable" id="_c5a0a897-ecdd-42da-8a41-58ec0842afac"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="13100.882" y="3815.0"/> </glyph> <glyph class="state variable" id="_337a613e-7ba4-470a-b73d-8bd0a4f06e68"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="13021.992" y="3775.0"/> </glyph> <glyph class="state variable" id="_3615e688-a394-4f0c-b7d2-07865ec63b71"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="13101.5" y="3775.2148"/> </glyph> <glyph class="state variable" id="_34e9b364-1158-41bb-beba-c1be18b34cf2"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="13061.404" y="3815.0"/> </glyph> <glyph class="state variable" id="_c68705d4-fa41-40e1-aabb-42f88c1c5871"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="13061.532" y="3775.0"/> </glyph> <glyph class="state variable" id="_def548f8-f6ca-412d-b467-1ba3d141f600"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="13021.5" y="3814.7224"/> </glyph> <glyph class="state variable" id="_350916e9-66b7-45a3-80c8-bdfb8a0f1f41"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13114.0" y="3775.0"/> </glyph> <glyph class="state variable" id="_2e319ec6-fce9-4ca3-a15c-fc6990d4acfa"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="13101.5" y="3814.1306"/> </glyph> <glyph class="state variable" id="_0a219078-61f3-4cf3-80a3-35c11945000b"> <state value="P" variable="S2034"/> <bbox w="40.0" h="10.0" x="13019.0" y="3814.7224"/> </glyph> <glyph class="state variable" id="_a3be1004-113f-4863-a3a6-65cb506ebb98"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13026.992" y="3775.0"/> </glyph> <glyph class="state variable" id="_609274db-186f-4373-8181-a02451ef0e73"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="13021.992" y="3775.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s341_wca1_wca3_sa254"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 2 regulatory subunit B' alpha HUGO:PPP2R5A HGNC:9309 ENTREZ:5525 UNIPROT:Q15172 GENECARDS:PPP2R5A REACTOME:49115 KEGG:5525 ATLASONC:GC_PPP2R5A WIKI:PPP2R5A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="B56α*"/> <bbox w="80.0" h="40.0" x="13039.0" y="3826.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s336_wca1_wca3_csa40" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC:B56_alpha_* Identifiers_end References_begin: s_wca3_re83(MAP:survival): Import of APC does not require phosphorylation of APC PMID:12223464 s_wca3_re94:(MAP:survival) Not known if this dissociation occurs (here or later) References_end</body> </html> </notes> <label text="APC:B56α*"/> <bbox w="100.0" h="120.0" x="13222.0" y="3600.0"/> <glyph class="macromolecule" id="wca1_wca3_s338_wca1_wca3_sa239"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="13233.75" y="3613.0"/> <glyph class="state variable" id="_1b4b54a2-6dec-4fe3-bee4-2ec6b6a8ce33"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="13295.632" y="3648.0"/> </glyph> <glyph class="state variable" id="_00827fa2-e1c6-4886-886f-2d4eaa05f30b"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="13216.742" y="3608.0"/> </glyph> <glyph class="state variable" id="_7848aff4-19b6-4270-8891-a5eec7970189"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="13296.25" y="3608.2148"/> </glyph> <glyph class="state variable" id="_f6eb43d3-4eb9-4609-a36d-f41384ec5a9c"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="13256.154" y="3648.0"/> </glyph> <glyph class="state variable" id="_28e6a58d-108b-4fb1-a02c-3a76e75b58f5"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="13256.282" y="3608.0"/> </glyph> <glyph class="state variable" id="_9ca71357-4ec6-45c1-99c3-adf96e29b1d6"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="13216.25" y="3647.7224"/> </glyph> <glyph class="state variable" id="_1eebfabc-1fea-40ad-b627-4eeee4ad95a2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13308.75" y="3608.0"/> </glyph> <glyph class="state variable" id="_95b28a33-21ba-4221-88ee-dfcfc5340ab3"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="13296.25" y="3647.1306"/> </glyph> <glyph class="state variable" id="_11858968-4629-491a-95e0-1fdaec886bb3"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="13216.25" y="3647.7224"/> </glyph> <glyph class="state variable" id="_e5c39dbe-18ac-4dec-8469-24f9490ac86e"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13221.742" y="3608.0"/> </glyph> <glyph class="state variable" id="_f29e8971-9eba-4696-92fa-60252d108b3c"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="13216.742" y="3608.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s337_wca1_wca3_sa256"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 2 regulatory subunit B' alpha HUGO:PPP2R5A HGNC:9309 ENTREZ:5525 UNIPROT:Q15172 GENECARDS:PPP2R5A REACTOME:49115 KEGG:5525 ATLASONC:GC_PPP2R5A WIKI:PPP2R5A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="B56α*"/> <bbox w="80.0" h="40.0" x="13233.0" y="3655.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s339_wca1_wca3_csa41" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC:B56_alpha_* Identifiers_end References_begin: s_wca3_re79(MAP:survival): This transport is enhanced upon phosphorylation however it is not necessary for import of APC into nucleus PMID:11689703 PMID:15649893 PMID:11050185 PMID:12223464 s_wca3_re93:(MAP:survival) Not known if this dissociation occurs (here or later) References_end</body> </html> </notes> <label text="APC:B56α*"/> <bbox w="100.0" h="120.0" x="13179.0" y="3776.0"/> <glyph class="macromolecule" id="wca1_wca3_s334_wca1_wca3_sa259"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="13191.0" y="3787.0"/> <glyph class="state variable" id="_9bc7c794-a224-44ff-b054-193f05e5584d"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="13252.882" y="3822.0"/> </glyph> <glyph class="state variable" id="_f34fc6d2-7088-4e99-b824-660b6151d4d8"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="13173.992" y="3782.0"/> </glyph> <glyph class="state variable" id="_976a0a1b-22b3-45d2-805e-0f453eb74f68"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="13253.5" y="3782.2148"/> </glyph> <glyph class="state variable" id="_735623c9-8389-4fe2-917b-0dff484ced7c"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="13213.404" y="3822.0"/> </glyph> <glyph class="state variable" id="_605786f5-83f8-4bca-b16f-22a3d152cfbf"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="13213.532" y="3782.0"/> </glyph> <glyph class="state variable" id="_452e68ef-00f4-43fe-a8f3-02c7c2cd128d"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="13173.5" y="3821.7224"/> </glyph> <glyph class="state variable" id="_f23a3c1d-7b01-436f-9974-816f00ef5d9a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13266.0" y="3782.0"/> </glyph> <glyph class="state variable" id="_ccf7ceec-75b8-499b-ac95-834d6c5a3290"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="13253.5" y="3821.1306"/> </glyph> <glyph class="state variable" id="_a44c4821-0de5-4dbf-b522-8cfc073cc5a8"> <state value="P" variable="S2034"/> <bbox w="40.0" h="10.0" x="13171.0" y="3821.7224"/> </glyph> <glyph class="state variable" id="_f795dc74-4577-4ce5-86cf-9ca9a7e734bf"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13178.992" y="3782.0"/> </glyph> <glyph class="state variable" id="_e5b33570-dc45-45ff-9610-cca7169aaa34"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="13173.992" y="3782.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s333_wca1_wca3_sa260"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: protein phosphatase 2 regulatory subunit B' alpha HUGO:PPP2R5A HGNC:9309 ENTREZ:5525 UNIPROT:Q15172 GENECARDS:PPP2R5A REACTOME:49115 KEGG:5525 ATLASONC:GC_PPP2R5A WIKI:PPP2R5A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="B56α*"/> <bbox w="80.0" h="40.0" x="13191.0" y="3833.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s365_wca1_wca3_csa44" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC:CTBP* Identifiers_end References_begin: s_wca3_re104:(MAP:survival) PMID:15525529 s_wca3_re106:(MAP:survival) PMID:12681518 PMID:16510874 References_end</body> </html> </notes> <label text="APC:CTBP*"/> <bbox w="100.0" h="120.0" x="13649.0" y="4290.0"/> <glyph class="macromolecule" id="wca1_wca3_s366_wca1_wca3_sa280"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="13659.75" y="4307.0"/> <glyph class="state variable" id="_0a2b963e-a22a-4e29-9bca-f868cd1d158c"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="13721.632" y="4342.0"/> </glyph> <glyph class="state variable" id="_b42d871d-b362-4ed3-9be1-13e25a3a93f2"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="13642.742" y="4302.0"/> </glyph> <glyph class="state variable" id="_0087afb7-6839-41e9-ab19-b4a1e473850a"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="13722.25" y="4302.215"/> </glyph> <glyph class="state variable" id="_a9f11097-7952-4d5e-9eb6-8b98edcfe088"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="13682.154" y="4342.0"/> </glyph> <glyph class="state variable" id="_86146a71-11e9-4752-a66c-0decad13b963"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="13682.282" y="4302.0"/> </glyph> <glyph class="state variable" id="_bbcbcd83-f9c6-4f4a-8a1f-0439229c6f10"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="13642.25" y="4341.722"/> </glyph> <glyph class="state variable" id="_e4023491-1a96-4ebb-9a48-84821b13105f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13734.75" y="4302.0"/> </glyph> <glyph class="state variable" id="_fa029a28-ea0e-40e7-98ca-4a788d92594b"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="13722.25" y="4341.131"/> </glyph> <glyph class="state variable" id="_b2b5bff1-61ca-4318-b8bf-101852478004"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="13642.25" y="4341.722"/> </glyph> <glyph class="state variable" id="_02d64ab6-8a9d-4ade-8b55-ab24deaf52b0"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13647.742" y="4302.0"/> </glyph> <glyph class="state variable" id="_c0119f52-b575-4371-999a-b64aed9c1771"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="13642.742" y="4302.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="wca1_wca3_s384_wca1_wca3_sa289"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: C-terminal binding protein 1 HUGO:CTBP1 HGNC:2494 ENTREZ:1487 UNIPROT:Q13363 GENECARDS:CTBP1 KEGG:1487 ATLASONC:GC_CTBP1 WIKI:CTBP1 C-terminal binding protein 2 HUGO:CTBP2 HGNC:2495 ENTREZ:1488 UNIPROT:P56545 GENECARDS:CTBP2 ATLASONC:GC_CTBP2 WIKI:CTBP2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTBP*"/> <bbox w="86.0" h="46.0" x="13658.5" y="4352.5"/> <glyph class="unit of information" id="_ec207506-6f94-4114-8654-916658943c7d"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="13691.5" y="4347.5"/> </glyph> <glyph class="state variable" id="_c1313830-2eef-44b7-919b-b394f27882df"> <state value="" variable="S422"/> <bbox w="30.0" h="10.0" x="13729.5" y="4347.747"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s379_wca1_wca3_csa45" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC:CTBP*:HDAC1_2* Identifiers_end References_begin: s_wca3_re106:(MAP:survival) PMID:12681518 PMID:16510874 s_wca3_re107:(MAP:survival) PMID:15327769 References_end</body> </html> </notes> <label text="APC:CTBP*:HDAC1_2*"/> <bbox w="98.0" h="161.0" x="13805.0" y="4255.0"/> <glyph class="macromolecule" id="wca1_wca3_s377_wca1_wca3_sa284"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="13814.0" y="4265.0"/> <glyph class="state variable" id="_13813ace-bf2b-4f67-9d63-267331a9917b"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="13875.882" y="4300.0"/> </glyph> <glyph class="state variable" id="_d517d08b-b4b1-431b-aff2-66e92eab1cdb"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="13796.992" y="4260.0"/> </glyph> <glyph class="state variable" id="_f233ea6d-facf-4e03-9367-fbd8d35cfb03"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="13876.5" y="4260.215"/> </glyph> <glyph class="state variable" id="_76205559-1a05-435b-8516-6ff7040d9490"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="13836.404" y="4300.0"/> </glyph> <glyph class="state variable" id="_89d7ac73-00d8-489b-8c23-b70d1f9738cd"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="13836.532" y="4260.0"/> </glyph> <glyph class="state variable" id="_2bded92e-9f30-44a6-b601-8b99aca1a717"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="13796.5" y="4299.722"/> </glyph> <glyph class="state variable" id="_723a7d7f-36ec-4474-9362-bacc41444836"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13889.0" y="4260.0"/> </glyph> <glyph class="state variable" id="_63e5c954-50eb-4909-8fbf-e622d991a419"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="13876.5" y="4299.131"/> </glyph> <glyph class="state variable" id="_e09f1663-7110-4a88-813e-2219ca5d68e0"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="13796.5" y="4299.722"/> </glyph> <glyph class="state variable" id="_1fa0a3e4-2226-451a-a35d-86a02edc29e5"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13801.992" y="4260.0"/> </glyph> <glyph class="state variable" id="_308d36e2-f280-40aa-a24d-7682abab698e"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="13796.992" y="4260.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s378_wca1_wca3_sa285"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: histone deacetylase 1 HUGO:HDAC1 HGNC:4852 ENTREZ:3065 UNIPROT:Q13547 GENECARDS:HDAC1 REACTOME:56408 KEGG:3065 ATLASONC:GC_HDAC1 WIKI:HDAC1 HUGO:HDAC2 HGNC:4853 ENTREZ:3066 UNIPROT:Q92769 GENECARDS:HDAC2 REACTOME:56410 KEGG:3066 ATLASONC:HDAC2ID40803ch6q22 WIKI:HDAC2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HDAC1_2*"/> <bbox w="80.0" h="40.0" x="13812.0" y="4357.0"/> </glyph> <glyph class="macromolecule multimer" id="wca1_wca3_s386_wca1_wca3_sa290"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: C-terminal binding protein 1 HUGO:CTBP1 HGNC:2494 ENTREZ:1487 UNIPROT:Q13363 GENECARDS:CTBP1 KEGG:1487 ATLASONC:GC_CTBP1 WIKI:CTBP1 C-terminal binding protein 2 HUGO:CTBP2 HGNC:2495 ENTREZ:1488 UNIPROT:P56545 GENECARDS:CTBP2 ATLASONC:GC_CTBP2 WIKI:CTBP2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTBP*"/> <bbox w="86.0" h="46.0" x="13813.5" y="4312.5"/> <glyph class="unit of information" id="_fc266ff9-ed04-48de-a796-2de1f3eee1b1"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="13846.5" y="4307.5"/> </glyph> <glyph class="state variable" id="_b78d076a-17d3-4944-a23e-590e329b7e44"> <state value="" variable="S422"/> <bbox w="30.0" h="10.0" x="13884.5" y="4307.747"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s380_wca1_wca3_csa46" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC:CTBP*:HDAC1_2* Identifiers_end References_begin: s_wca3_re107:(MAP:survival) PMID:15327769 References_end</body> </html> </notes> <label text="APC:CTBP*:HDAC1_2*"/> <bbox w="98.0" h="161.0" x="13808.5" y="4474.0"/> <glyph class="macromolecule" id="wca1_wca3_s383_wca1_wca3_sa287"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="13818.5" y="4486.0"/> <glyph class="state variable" id="_590b60cc-2798-471a-9de9-d4ccb9bfa83e"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="13880.382" y="4521.0"/> </glyph> <glyph class="state variable" id="_d42cb795-bf56-40c8-9175-f5761c168f7e"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="13801.492" y="4481.0"/> </glyph> <glyph class="state variable" id="_e52d04e5-659c-4079-b5e3-8cef4585ea58"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="13881.0" y="4481.215"/> </glyph> <glyph class="state variable" id="_35c798b7-6c13-48bd-ac69-878ff0f823b5"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="13840.904" y="4521.0"/> </glyph> <glyph class="state variable" id="_117b06d5-095b-4bf0-bcf4-33a29e7ee3f6"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="13841.032" y="4481.0"/> </glyph> <glyph class="state variable" id="_f023a162-2904-4962-bc42-be123245ef18"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="13801.0" y="4520.722"/> </glyph> <glyph class="state variable" id="_b27fa4eb-ccb7-4b75-8127-56c17f4f0c4b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13893.5" y="4481.0"/> </glyph> <glyph class="state variable" id="_a3381211-70c3-40b1-9dca-48d47c5ec5ca"> <state value="P" variable="T1487"/> <bbox w="40.0" h="10.0" x="13878.5" y="4520.131"/> </glyph> <glyph class="state variable" id="_788b5b8f-d904-4cf7-8f44-80bd4fbb10fd"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="13801.0" y="4520.722"/> </glyph> <glyph class="state variable" id="_ea80b071-b453-4727-b538-2589b67c79f8"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13806.492" y="4481.0"/> </glyph> <glyph class="state variable" id="_6aa612ca-9416-4979-a9ad-b38f6edb6c15"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="13801.492" y="4481.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s382_wca1_wca3_sa288"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: histone deacetylase 1 HUGO:HDAC1 HGNC:4852 ENTREZ:3065 UNIPROT:Q13547 GENECARDS:HDAC1 REACTOME:56408 KEGG:3065 ATLASONC:GC_HDAC1 WIKI:HDAC1 HUGO:HDAC2 HGNC:4853 ENTREZ:3066 UNIPROT:Q92769 GENECARDS:HDAC2 REACTOME:56410 KEGG:3066 ATLASONC:HDAC2ID40803ch6q22 WIKI:HDAC2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HDAC1_2*"/> <bbox w="80.0" h="40.0" x="13817.5" y="4571.0"/> </glyph> <glyph class="macromolecule multimer" id="wca1_wca3_s385_wca1_wca3_sa291"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: C-terminal binding protein 1 HUGO:CTBP1 HGNC:2494 ENTREZ:1487 UNIPROT:Q13363 GENECARDS:CTBP1 KEGG:1487 ATLASONC:GC_CTBP1 WIKI:CTBP1 C-terminal binding protein 2 HUGO:CTBP2 HGNC:2495 ENTREZ:1488 UNIPROT:P56545 GENECARDS:CTBP2 ATLASONC:GC_CTBP2 WIKI:CTBP2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTBP*"/> <bbox w="86.0" h="46.0" x="13813.5" y="4533.5"/> <glyph class="unit of information" id="_a3e0d34d-d5e5-42a3-a5f7-ee3504ca2d4a"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="13846.5" y="4528.5"/> </glyph> <glyph class="state variable" id="_fc97ff6a-1750-42e9-a4c9-830cba780004"> <state value="" variable="S422"/> <bbox w="30.0" h="10.0" x="13884.5" y="4528.747"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s404_wca1_wca3_csa50" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC:_beta_-Catenin* Identifiers_end References_begin: s_wca3_re109:(MAP:survival) PMID:12711682 PMID:15834423 PMID:16510874 PMID:15327769 PMID:16547505 References_end</body> </html> </notes> <label text="APC:β-Catenin*"/> <bbox w="100.0" h="120.0" x="13817.0" y="4674.0"/> <glyph class="macromolecule" id="wca1_wca3_s398_wca1_wca3_sa314"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="13829.5" y="4688.0"/> <glyph class="state variable" id="_987279d0-bd6d-4cf9-b5e6-0cbd59583955"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="13891.382" y="4723.0"/> </glyph> <glyph class="state variable" id="_b3fb8160-fee9-424e-9cee-2c2e45b64384"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="13812.492" y="4683.0"/> </glyph> <glyph class="state variable" id="_5898a641-d967-4351-b058-d5adb530fd57"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="13892.0" y="4683.215"/> </glyph> <glyph class="state variable" id="_932b43bb-16e8-4c2a-be30-95721c619a91"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="13851.904" y="4723.0"/> </glyph> <glyph class="state variable" id="_1a0137af-50cd-4514-8d4d-1f5a96e4b2cc"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="13852.032" y="4683.0"/> </glyph> <glyph class="state variable" id="_8065a2fc-235f-495c-8a09-a3434cbab72d"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="13812.0" y="4722.722"/> </glyph> <glyph class="state variable" id="_b4d167c7-5df6-43a8-a479-3ca44979d28e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13904.5" y="4683.0"/> </glyph> <glyph class="state variable" id="_64e29f46-e9be-45c3-a774-fe2de21f2835"> <state value="P" variable="T1487"/> <bbox w="40.0" h="10.0" x="13889.5" y="4722.131"/> </glyph> <glyph class="state variable" id="_93349274-7602-4144-8a5d-41acf6f67a7d"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="13812.0" y="4722.722"/> </glyph> <glyph class="state variable" id="_ed5d2f35-1793-4771-9f14-801a0de6461b"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13817.492" y="4683.0"/> </glyph> <glyph class="state variable" id="_963f5ad9-ef9a-4d17-b5cc-c8233750688c"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="13812.492" y="4683.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s399_wca1_wca3_sa315"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="13829.5" y="4741.0"/> <glyph class="state variable" id="_a5bdb6de-d7a6-4c8a-b53a-e4023fc5dc05"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="13856.904" y="4776.0"/> </glyph> <glyph class="state variable" id="_bb86d7e3-a1ce-47a4-9d81-56f043781d43"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="13896.382" y="4776.0"/> </glyph> <glyph class="state variable" id="_a6d4c78c-2102-4d31-9579-98a3aa3355f8"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="13897.0" y="4736.215"/> </glyph> <glyph class="state variable" id="_1ce3ba39-6353-4fa4-a737-45b7bef5ba50"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="13857.032" y="4736.0"/> </glyph> <glyph class="state variable" id="_88fa68cf-ab97-4ed0-b37e-2032e326d7a2"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="13817.492" y="4736.0"/> </glyph> <glyph class="state variable" id="_c9c5d395-2c63-4dae-a85e-68cc08219390"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="13817.0" y="4775.722"/> </glyph> <glyph class="state variable" id="_f1778d6f-33c7-4a96-8434-67b0497e8c8d"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="13894.5" y="4736.215"/> </glyph> <glyph class="state variable" id="_ce550d21-8c12-4d3c-982d-71ab076c039c"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="13894.5" y="4736.215"/> </glyph> <glyph class="state variable" id="_e142eb6f-172a-4838-9e6f-f5bbf0d30a9c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13824.5" y="4756.0"/> </glyph> <glyph class="state variable" id="_c8d04132-d04a-4059-b676-2e1d404275da"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="13814.992" y="4736.0"/> </glyph> <glyph class="state variable" id="_e06ee9ab-4581-48e8-ac94-b403dda3b7a2"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="13894.5" y="4736.215"/> </glyph> <glyph class="state variable" id="_dbd43b1d-4738-4957-b3d9-b2de2937dd73"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13824.5" y="4747.716"/> </glyph> <glyph class="state variable" id="_15f57dd6-234b-4175-bcad-fa3a865c4ca0"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="13894.5" y="4736.215"/> </glyph> <glyph class="state variable" id="_e437907b-86b6-4aa5-a8a6-32ad5e3dec77"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13824.5" y="4756.0"/> </glyph> <glyph class="state variable" id="_273fe2a7-e949-4d19-a132-0391e065a516"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="13893.882" y="4776.0"/> </glyph> <glyph class="state variable" id="_90a5583e-41fe-4229-b111-93b059d6c73c"> <state value="Ac" variable="K345"/> <bbox w="40.0" h="10.0" x="13889.5" y="4736.215"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s405_wca1_wca3_csa51" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CTBP*:p300* Identifiers_end References_begin: s_wca3_re109:(MAP:survival) PMID:12711682 PMID:15834423 PMID:16510874 PMID:15327769 PMID:16547505 References_end</body> </html> </notes> <label text="CTBP*:p300*"/> <bbox w="100.0" h="120.0" x="13826.0" y="4818.0"/> <glyph class="macromolecule" id="wca1_wca3_s407_wca1_wca3_sa316"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: C-terminal binding protein 1 HUGO:CTBP1 HGNC:2494 ENTREZ:1487 UNIPROT:Q13363 GENECARDS:CTBP1 KEGG:1487 ATLASONC:GC_CTBP1 WIKI:CTBP1 C-terminal binding protein 2 HUGO:CTBP2 HGNC:2495 ENTREZ:1488 UNIPROT:P56545 GENECARDS:CTBP2 ATLASONC:GC_CTBP2 WIKI:CTBP2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTBP*"/> <bbox w="80.0" h="40.0" x="13839.5" y="4831.0"/> <glyph class="state variable" id="_7a37a6c2-ef4b-4087-905d-07cbf1022f20"> <state value="" variable="S422"/> <bbox w="30.0" h="10.0" x="13904.5" y="4826.215"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s406_wca1_wca3_sa317"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: E1A binding protein p300 HUGO:EP300 HGNC:3373 ENTREZ:2033 UNIPROT:Q09472 GENECARDS:EP300 REACTOME:61164 KEGG:2033 ATLASONC:P300ID97 WIKI:EP300 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:HIF1 MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="p300*"/> <bbox w="80.0" h="40.0" x="13839.5" y="4875.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s413_wca1_wca3_csa52" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CTBP*:HDAC1_2*:LEF_TCF*:WRE* Identifiers_end References_begin: s_wca3_re109:(MAP:survival) PMID:12711682 PMID:15834423 PMID:16510874 PMID:15327769 PMID:16547505 References_end</body> </html> </notes> <label text="CTBP*:HDAC1_2*:LEF_TCF*:WRE*"/> <bbox w="103.0" h="213.0" x="13804.0" y="4964.0"/> <glyph class="macromolecule" id="wca1_wca3_s411_wca1_wca3_sa318"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>TCF family: tcf-1, lef-1, tcf-3, tcf-4 PMID:11266540 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 transcription factor 7-like 1 (T-cell specific HMG-box) TCF3 HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 transcription factor 7-like 2 (T-cell specific HMG-box) TCF4 HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end</body> </html> </notes> <label text="LEF_TCF*"/> <bbox w="80.0" h="40.0" x="13811.375" y="5059.5"/> <glyph class="state variable" id="_e5303466-b086-47bc-ad6e-cef19a570871"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13886.375" y="5055.378"/> </glyph> <glyph class="state variable" id="_4475a55c-b98b-4c01-b89b-89ec150bda99"> <state value="" variable="S40"/> <bbox w="25.0" h="10.0" x="13878.875" y="5091.1143"/> </glyph> <glyph class="state variable" id="_3df1bedb-7e45-4dbd-8309-3892b6250efb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13886.375" y="5074.5"/> </glyph> <glyph class="state variable" id="_039faa9d-5ed0-4cae-b8c0-3245f9859004"> <state value="" variable="S166"/> <bbox w="30.0" h="10.0" x="13796.867" y="5054.5"/> </glyph> <glyph class="state variable" id="_1f99762a-f312-43ac-855c-d548d3b86971"> <state value="" variable="T155"/> <bbox w="30.0" h="10.0" x="13796.375" y="5094.222"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_wca3_s412_wca1_wca3_sa319"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: WNT responsive element References_end</body> </html> </notes> <label text="WRE*"/> <bbox w="70.0" h="25.0" x="13815.875" y="5106.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s410_wca1_wca3_sa320"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: histone deacetylase 1 HUGO:HDAC1 HGNC:4852 ENTREZ:3065 UNIPROT:Q13547 GENECARDS:HDAC1 REACTOME:56408 KEGG:3065 ATLASONC:GC_HDAC1 WIKI:HDAC1 HUGO:HDAC2 HGNC:4853 ENTREZ:3066 UNIPROT:Q92769 GENECARDS:HDAC2 REACTOME:56410 KEGG:3066 ATLASONC:HDAC2ID40803ch6q22 WIKI:HDAC2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HDAC1_2*"/> <bbox w="80.0" h="40.0" x="13812.625" y="4970.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s409_wca1_wca3_sa321"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: C-terminal binding protein 1 HUGO:CTBP1 HGNC:2494 ENTREZ:1487 UNIPROT:Q13363 GENECARDS:CTBP1 KEGG:1487 ATLASONC:GC_CTBP1 WIKI:CTBP1 C-terminal binding protein 2 HUGO:CTBP2 HGNC:2495 ENTREZ:1488 UNIPROT:P56545 GENECARDS:CTBP2 ATLASONC:GC_CTBP2 WIKI:CTBP2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTBP*"/> <bbox w="80.0" h="40.0" x="13812.875" y="5016.0"/> <glyph class="state variable" id="_0969b435-6e6f-4753-858c-54dc6007c039"> <state value="" variable="S422"/> <bbox w="30.0" h="10.0" x="13877.875" y="5011.215"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s414_wca1_wca3_csa53" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC:_beta_-Catenin* Identifiers_end References_begin: s_wca3_re110:(MAP:survival) PMID:16510874 References_end</body> </html> </notes> <label text="APC:β-Catenin*"/> <bbox w="101.0" h="132.0" x="12888.0" y="4337.0"/> <glyph class="macromolecule" id="wca1_wca3_s415_wca1_wca3_sa322"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="12900.5" y="4351.0"/> <glyph class="state variable" id="_6628c88d-003c-4310-9d6c-e5ded0194cc2"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="12962.382" y="4386.0"/> </glyph> <glyph class="state variable" id="_0aff8085-ac68-4e2e-bd80-a446eaa2565c"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="12883.492" y="4346.0"/> </glyph> <glyph class="state variable" id="_3efcb104-ce98-4fbe-be07-f16998b7e7a5"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="12963.0" y="4346.215"/> </glyph> <glyph class="state variable" id="_aabeb2c1-05e4-4bb7-95ce-f5dfa780a556"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="12922.904" y="4386.0"/> </glyph> <glyph class="state variable" id="_2e024aa9-4ddc-41b2-aa17-dc9bb042919c"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="12923.032" y="4346.0"/> </glyph> <glyph class="state variable" id="_35d0c8f5-80c6-476b-a5ac-bf5b91318bd6"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="12883.0" y="4385.722"/> </glyph> <glyph class="state variable" id="_183e605d-83a1-4371-ad1b-7bd3e5cbb20f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12975.5" y="4346.0"/> </glyph> <glyph class="state variable" id="_6177bdf4-691b-49b3-9550-e088ddf83a07"> <state value="P" variable="T1487"/> <bbox w="40.0" h="10.0" x="12960.5" y="4385.131"/> </glyph> <glyph class="state variable" id="_13562724-aa1a-4435-b419-8dbe6a833677"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="12883.0" y="4385.722"/> </glyph> <glyph class="state variable" id="_d0e967c7-ef51-43a9-a497-ca1eb13f0984"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12888.492" y="4346.0"/> </glyph> <glyph class="state variable" id="_974a5e51-785a-4ff4-8a9a-8baa379100fd"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="12883.492" y="4346.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s416_wca1_wca3_sa323"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="12900.5" y="4404.0"/> <glyph class="state variable" id="_f8b00aed-4d07-4e37-bf1c-2fd09db1cc8c"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="12927.904" y="4439.0"/> </glyph> <glyph class="state variable" id="_d3cc16e8-0c93-44ab-80ba-75401064aece"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="12967.382" y="4439.0"/> </glyph> <glyph class="state variable" id="_d17823e8-75c7-4aa8-9e49-1f479dc0245b"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="12968.0" y="4399.215"/> </glyph> <glyph class="state variable" id="_06d8ad47-d795-4260-afee-9c91a95e823c"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="12928.032" y="4399.0"/> </glyph> <glyph class="state variable" id="_58ca6f6f-5e34-4641-94f6-d8870a9db151"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="12888.492" y="4399.0"/> </glyph> <glyph class="state variable" id="_424fca8c-c365-4817-891b-e1bd6bfb10e6"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="12888.0" y="4438.722"/> </glyph> <glyph class="state variable" id="_97a5e5ed-586b-444d-b783-109460c23b36"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="12965.5" y="4399.215"/> </glyph> <glyph class="state variable" id="_cf5b2d2d-c3f8-472f-a802-76a5ac61b7d7"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="12965.5" y="4399.215"/> </glyph> <glyph class="state variable" id="_56c55a6f-abae-43ea-8371-db9d2a721e9e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12895.5" y="4419.0"/> </glyph> <glyph class="state variable" id="_1e91f34d-0a4d-4bed-b2c2-dd0b5a904c4b"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="12885.992" y="4399.0"/> </glyph> <glyph class="state variable" id="_22a77097-f440-48aa-a628-8f836be2fa0a"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="12965.5" y="4399.215"/> </glyph> <glyph class="state variable" id="_eae50483-391e-41bc-bf17-117adb3539ed"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12895.5" y="4410.716"/> </glyph> <glyph class="state variable" id="_8c9021a9-f234-4efb-b6cf-7428ef8d7963"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="12965.5" y="4399.215"/> </glyph> <glyph class="state variable" id="_06da6733-db41-43bb-87e8-ecf2b9bf9cf7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12895.5" y="4419.0"/> </glyph> <glyph class="state variable" id="_32358f83-71f9-404c-b675-eaa69f2fb6bf"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="12964.882" y="4439.0"/> </glyph> <glyph class="state variable" id="_eb71ae03-56a4-4e46-8b28-a32cc96c8425"> <state value="Ac" variable="K345"/> <bbox w="40.0" h="10.0" x="12960.5" y="4399.215"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s435_wca1_wca3_csa54" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL9:KLF8:PYGO*:_beta_-Catenin*:p300* Identifiers_end References_begin: s_wca3_re114(MAP:survival): KLF8 recruits P300 PMID:22761862 PMID:20107328 s_wca3_re115:(MAP:survival) PMID:21416054 References_end</body> </html> </notes> <label text="BCL9:KLF8:PYGO*:β-Catenin*:p300*"/> <bbox w="108.0" h="267.0" x="13371.25" y="4031.5"/> <glyph class="macromolecule" id="wca1_wca3_s429_wca1_wca3_sa327"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: B-cell CLL/lymphoma 9 HUGO:BCL9 HGNC:1008 ENTREZ:607 UNIPROT:O00512 GENECARDS:BCL9 KEGG:607 ATLASONC:BCL9ID466 WIKI:BCL9 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BCL9"/> <bbox w="80.0" h="40.0" x="13386.3125" y="4170.25"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s430_wca1_wca3_sa328"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: pygopus homolog 1 (Drosophila) HUGO:PYGO1 HGNC:30256 ENTREZ:26108 UNIPROT:Q9Y3Y4 GENECARDS:PYGO1 WIKI:PYGO1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PYGO*"/> <bbox w="80.0" h="40.0" x="13386.3125" y="4130.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s431_wca1_wca3_sa329"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="13385.8125" y="4210.5"/> <glyph class="state variable" id="_f9ce4dda-2a60-4f64-95fb-0aff0bceaf19"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="13413.217" y="4245.5"/> </glyph> <glyph class="state variable" id="_b0b86749-e2ba-42a1-8ef6-0a142f9c84e7"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="13452.694" y="4245.5"/> </glyph> <glyph class="state variable" id="_83623a5b-cd16-41c9-81c9-044bac752454"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="13453.3125" y="4205.715"/> </glyph> <glyph class="state variable" id="_90ced00a-72b0-4e40-874c-599fd8030e82"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="13413.345" y="4205.5"/> </glyph> <glyph class="state variable" id="_26844dca-7977-43b0-91bc-de63409fa106"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="13373.805" y="4205.5"/> </glyph> <glyph class="state variable" id="_b4cabe13-7c8e-4b1c-9fc6-bde138d74ccf"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="13373.3125" y="4245.222"/> </glyph> <glyph class="state variable" id="_3a3a064a-697c-4cc2-8106-97944da27bd1"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="13450.8125" y="4205.715"/> </glyph> <glyph class="state variable" id="_befacaa2-9430-40de-97e4-01078c403540"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="13450.8125" y="4205.715"/> </glyph> <glyph class="state variable" id="_a29b1f55-93b0-4cd6-9103-605d713c8d38"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13380.8125" y="4225.5"/> </glyph> <glyph class="state variable" id="_b78da263-c408-40e1-ba95-05deee545162"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="13371.305" y="4205.5"/> </glyph> <glyph class="state variable" id="_d864bbad-19f6-468d-965d-77b7851c5f4e"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="13450.8125" y="4205.715"/> </glyph> <glyph class="state variable" id="_3c86cb70-9856-4700-9d2e-3a1095f199f8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13380.8125" y="4217.216"/> </glyph> <glyph class="state variable" id="_de2c63ba-f758-4bec-bf41-ba9df2ff3cbf"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="13450.8125" y="4205.715"/> </glyph> <glyph class="state variable" id="_b73e3969-c5b8-4ae2-84e1-ae435d35e04b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13380.8125" y="4225.5"/> </glyph> <glyph class="state variable" id="_3190349b-2487-4f64-9e60-855122f9c47e"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="13450.194" y="4245.5"/> </glyph> <glyph class="state variable" id="_ad467d46-37a7-44a5-a280-4f8604bf78a7"> <state value="Ac" variable="K345"/> <bbox w="40.0" h="10.0" x="13445.8125" y="4205.715"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s432_wca1_wca3_sa330"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: E1A binding protein p300 HUGO:EP300 HGNC:3373 ENTREZ:2033 UNIPROT:Q09472 GENECARDS:EP300 REACTOME:61164 KEGG:2033 ATLASONC:P300ID97 WIKI:EP300 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:HIF1 MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="p300*"/> <bbox w="80.0" h="40.0" x="13385.875" y="4089.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s433_wca1_wca3_sa331"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Kruppel-like factor 8 HUGO:KLF8 HGNC:6351 ENTREZ:11279 UNIPROT:O95600 GENECARDS:KLF8 KEGG:11279 ATLASONC:GC_KLF8 WIKI:KLF8 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="KLF8"/> <bbox w="80.0" h="40.0" x="13387.0" y="4045.0"/> <glyph class="state variable" id="_a78803b4-a022-4370-a37b-4ef80e1f0ff6"> <state value="" variable="K95"/> <bbox w="25.0" h="10.0" x="13454.5" y="4078.379"/> </glyph> <glyph class="state variable" id="_3f5f7fa6-94c5-4bb7-9043-683fca9e4e74"> <state value="" variable="K67"/> <bbox w="25.0" h="10.0" x="13374.5" y="4040.9302"/> </glyph> <glyph class="state variable" id="_ebbd36e0-c82b-4c3f-86ef-ada7f349c2b4"> <state value="" variable="K93"/> <bbox w="25.0" h="10.0" x="13453.349" y="4040.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s442_wca1_wca3_csa55" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL9:KLF8:PYGO*:_beta_-Catenin*:p300* Identifiers_end References_begin: s_wca3_re115:(MAP:survival) PMID:21416054 References_end</body> </html> </notes> <label text="BCL9:KLF8:PYGO*:β-Catenin*:p300*"/> <bbox w="108.0" h="267.0" x="13372.625" y="4378.5"/> <glyph class="macromolecule" id="wca1_wca3_s443_wca1_wca3_sa332"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: B-cell CLL/lymphoma 9 HUGO:BCL9 HGNC:1008 ENTREZ:607 UNIPROT:O00512 GENECARDS:BCL9 KEGG:607 ATLASONC:BCL9ID466 WIKI:BCL9 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BCL9"/> <bbox w="80.0" h="40.0" x="13387.6875" y="4517.25"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s444_wca1_wca3_sa333"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: pygopus homolog 1 (Drosophila) HUGO:PYGO1 HGNC:30256 ENTREZ:26108 UNIPROT:Q9Y3Y4 GENECARDS:PYGO1 WIKI:PYGO1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PYGO*"/> <bbox w="80.0" h="40.0" x="13387.6875" y="4477.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s445_wca1_wca3_sa334"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="13387.1875" y="4557.5"/> <glyph class="state variable" id="_8ce6b4ae-8c82-47d1-9a28-b780c40a5bc6"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="13414.592" y="4592.5"/> </glyph> <glyph class="state variable" id="_074c117b-d7ec-4b26-ba82-ed547bef815d"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="13454.069" y="4592.5"/> </glyph> <glyph class="state variable" id="_d102f282-402b-4381-a8ad-f1b8c75b85b2"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="13454.6875" y="4552.715"/> </glyph> <glyph class="state variable" id="_fb016108-bd53-4f2d-9a88-ccfb91fc1a8b"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="13414.72" y="4552.5"/> </glyph> <glyph class="state variable" id="_d2693063-e8c7-40d2-8e67-0a2c1fad3154"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="13375.18" y="4552.5"/> </glyph> <glyph class="state variable" id="_5441853c-d002-4940-923e-8312a4a6b608"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="13374.6875" y="4592.222"/> </glyph> <glyph class="state variable" id="_97c3dc02-2f20-4142-9b3e-68b6a76a4cd3"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="13452.1875" y="4552.715"/> </glyph> <glyph class="state variable" id="_a13bdad9-e33b-45f4-b4b8-cf898de1e090"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="13452.1875" y="4552.715"/> </glyph> <glyph class="state variable" id="_3803b131-20fe-4c9c-a93a-874aefbcd727"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13382.1875" y="4572.5"/> </glyph> <glyph class="state variable" id="_9fb1264a-9b12-44c0-beb1-9a9dec4b2cfa"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="13372.68" y="4552.5"/> </glyph> <glyph class="state variable" id="_605bdfea-6bbd-422a-8a14-e281edce40a5"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="13452.1875" y="4552.715"/> </glyph> <glyph class="state variable" id="_8decf900-6be1-4f46-8dd1-8abd9af881ae"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13382.1875" y="4564.216"/> </glyph> <glyph class="state variable" id="_27a97e7e-38bc-4e2d-84a2-24dc2195f1fe"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="13452.1875" y="4552.715"/> </glyph> <glyph class="state variable" id="_62e8919a-a2fe-45b5-8036-46d52255b8f6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13382.1875" y="4572.5"/> </glyph> <glyph class="state variable" id="_27d46c68-f63e-43b9-8443-c65b1188a73a"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="13451.569" y="4592.5"/> </glyph> <glyph class="state variable" id="_923ac135-031b-43aa-995d-c402f77a5d6e"> <state value="Ac" variable="K345"/> <bbox w="40.0" h="10.0" x="13447.1875" y="4552.715"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s446_wca1_wca3_sa335"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: E1A binding protein p300 HUGO:EP300 HGNC:3373 ENTREZ:2033 UNIPROT:Q09472 GENECARDS:EP300 REACTOME:61164 KEGG:2033 ATLASONC:P300ID97 WIKI:EP300 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:HIF1 MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="p300*"/> <bbox w="80.0" h="40.0" x="13387.25" y="4436.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s447_wca1_wca3_sa336"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Kruppel-like factor 8 HUGO:KLF8 HGNC:6351 ENTREZ:11279 UNIPROT:O95600 GENECARDS:KLF8 KEGG:11279 ATLASONC:GC_KLF8 WIKI:KLF8 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="KLF8"/> <bbox w="80.0" h="40.0" x="13388.375" y="4392.0"/> <glyph class="state variable" id="_478dcab9-9447-4595-879d-4189b77ab26d"> <state value="Ac" variable="K95"/> <bbox w="35.0" h="10.0" x="13450.875" y="4425.379"/> </glyph> <glyph class="state variable" id="_c104dfa9-61c7-449b-ae0a-3fa1e3d97b6b"> <state value="Ac" variable="K67"/> <bbox w="35.0" h="10.0" x="13370.875" y="4387.93"/> </glyph> <glyph class="state variable" id="_c39586eb-1cda-4096-a506-b13f1bc2ff56"> <state value="Ac" variable="K93"/> <bbox w="35.0" h="10.0" x="13449.724" y="4387.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s454_wca1_wca3_csa56" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CTBP*:KLF8 Identifiers_end References_begin: s_wca3_re118:(MAP:survival) PMID:10756197 s_wca3_re114(MAP:survival): KLF8 recruits P300 PMID:22761862 PMID:20107328 References_end</body> </html> </notes> <label text="CTBP*:KLF8"/> <bbox w="93.0" h="128.0" x="13169.0" y="4451.0"/> <glyph class="macromolecule" id="wca1_wca3_s455_wca1_wca3_sa341"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Kruppel-like factor 8 HUGO:KLF8 HGNC:6351 ENTREZ:11279 UNIPROT:O95600 GENECARDS:KLF8 KEGG:11279 ATLASONC:GC_KLF8 WIKI:KLF8 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="KLF8"/> <bbox w="80.0" h="40.0" x="13174.5" y="4466.0"/> <glyph class="state variable" id="_efb799ed-1e14-4146-a74d-934aa99aedce"> <state value="" variable="K95"/> <bbox w="25.0" h="10.0" x="13242.0" y="4499.379"/> </glyph> <glyph class="state variable" id="_b380e155-80a4-4df4-a12c-784f6e01935d"> <state value="" variable="K67"/> <bbox w="25.0" h="10.0" x="13162.0" y="4461.93"/> </glyph> <glyph class="state variable" id="_0ad1a94a-a963-4dd1-8f4d-5932053f2386"> <state value="" variable="K93"/> <bbox w="25.0" h="10.0" x="13240.849" y="4461.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s456_wca1_wca3_sa342"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: C-terminal binding protein 1 HUGO:CTBP1 HGNC:2494 ENTREZ:1487 UNIPROT:Q13363 GENECARDS:CTBP1 KEGG:1487 ATLASONC:GC_CTBP1 WIKI:CTBP1 C-terminal binding protein 2 HUGO:CTBP2 HGNC:2495 ENTREZ:1488 UNIPROT:P56545 GENECARDS:CTBP2 ATLASONC:GC_CTBP2 WIKI:CTBP2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTBP*"/> <bbox w="80.0" h="40.0" x="13175.0" y="4511.0"/> <glyph class="state variable" id="_8542f448-5044-48d5-a05b-3862bf196cc4"> <state value="" variable="S422"/> <bbox w="30.0" h="10.0" x="13240.0" y="4506.215"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s461_wca1_wca3_csa57" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CTBP*:KLF8 Identifiers_end References_begin: s_wca3_re113:(MAP:survival) PMID:21416054 References_end</body> </html> </notes> <label text="CTBP*:KLF8"/> <bbox w="93.0" h="128.0" x="13168.0" y="4625.0"/> <glyph class="macromolecule" id="wca1_wca3_s463_wca1_wca3_sa343"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: KLF8 is sumoylated by PIAS1, but this cannot be depicted in CellDesigner, instead it is depicted by using "?" as PTM PMID:16617055 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Kruppel-like factor 8 HUGO:KLF8 HGNC:6351 ENTREZ:11279 UNIPROT:O95600 GENECARDS:KLF8 KEGG:11279 ATLASONC:GC_KLF8 WIKI:KLF8 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="KLF8"/> <bbox w="80.0" h="40.0" x="13174.5" y="4641.0"/> <glyph class="state variable" id="_571ae7a4-7336-4cfa-9479-8cb751cea4f8"> <state value="" variable="K95"/> <bbox w="25.0" h="10.0" x="13242.0" y="4674.379"/> </glyph> <glyph class="state variable" id="_cd20d9ca-a89f-4a29-87e0-d8eae17591a7"> <state value="?" variable="K67"/> <bbox w="30.0" h="10.0" x="13159.5" y="4636.93"/> </glyph> <glyph class="state variable" id="_4a966944-9cf8-402e-872b-4a967a4fe949"> <state value="" variable="K93"/> <bbox w="25.0" h="10.0" x="13240.849" y="4636.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s462_wca1_wca3_sa344"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: C-terminal binding protein 1 HUGO:CTBP1 HGNC:2494 ENTREZ:1487 UNIPROT:Q13363 GENECARDS:CTBP1 KEGG:1487 ATLASONC:GC_CTBP1 WIKI:CTBP1 C-terminal binding protein 2 HUGO:CTBP2 HGNC:2495 ENTREZ:1488 UNIPROT:P56545 GENECARDS:CTBP2 ATLASONC:GC_CTBP2 WIKI:CTBP2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTBP*"/> <bbox w="80.0" h="40.0" x="13174.5" y="4683.0"/> <glyph class="state variable" id="_2b9f86b5-f9fc-40fa-a017-5afb203bfd55"> <state value="" variable="S422"/> <bbox w="30.0" h="10.0" x="13239.5" y="4678.215"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s476_wca1_wca3_csa58" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL9:KLF8:LEF_TCF*:PYGO*:WRE*:_beta_-Catenin*:p300* Identifiers_end References_begin: s_wca3_re65(MAP:survival): PMID:22761862 Smad1 alone inhibits myc expression while b-catenin/TCF4 activates gene expression. Highest gene expression obtained when SMAD1/b-catenin/TCF4 complex is formed PMID:15576399 Mi-2/NuRD PMID:22290435 s_wca3_re116(MAP:survival): Swi/SNF complex NuRD complex: b-catenin/CTBP/Hipk2/LEF1 complex PMID:17666529 s_wca3_re122(MAP:survival): Not sure if this mechanism is exact the same as for CYCLIND Myc and AXIN1 transcription. However it has been shown that KLF8 and b-catenin induces transcription of MMP9 gene. PMID:21151179 PMID:17306568 References_end</body> </html> </notes> <label text="BCL9:KLF8:LEF_TCF*:PYGO*:WRE*:β-Catenin*:p300*"/> <bbox w="195.0" h="203.0" x="13554.8125" y="4431.5"/> <glyph class="macromolecule" id="wca1_wca3_s469_wca1_wca3_sa350"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: B-cell CLL/lymphoma 9 HUGO:BCL9 HGNC:1008 ENTREZ:607 UNIPROT:O00512 GENECARDS:BCL9 KEGG:607 ATLASONC:BCL9ID466 WIKI:BCL9 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BCL9"/> <bbox w="80.0" h="40.0" x="13650.875" y="4440.25"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s470_wca1_wca3_sa351"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: pygopus homolog 1 (Drosophila) HUGO:PYGO1 HGNC:30256 ENTREZ:26108 UNIPROT:Q9Y3Y4 GENECARDS:PYGO1 WIKI:PYGO1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PYGO*"/> <bbox w="80.0" h="40.0" x="13569.875" y="4527.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s471_wca1_wca3_sa352"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="13650.375" y="4480.5"/> <glyph class="state variable" id="_91adb158-8736-4192-a6e3-a737b83460af"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="13677.779" y="4515.5"/> </glyph> <glyph class="state variable" id="_2eceab34-36f6-4a5c-8f47-c43e6ef42f84"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="13717.257" y="4515.5"/> </glyph> <glyph class="state variable" id="_722aeb72-1f6f-4a5f-959c-d12b5533ecfa"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="13717.875" y="4475.715"/> </glyph> <glyph class="state variable" id="_5fbc436b-f62f-4c0c-bc0a-7c48703e3b37"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="13677.907" y="4475.5"/> </glyph> <glyph class="state variable" id="_8820400f-01b5-4dc5-b367-a9f882f57e3c"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="13638.367" y="4475.5"/> </glyph> <glyph class="state variable" id="_10026d53-c7bb-4e50-8dd7-ae7b47027afb"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="13637.875" y="4515.222"/> </glyph> <glyph class="state variable" id="_384822a1-d0ea-46e4-9eaf-8df14cdf1447"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="13715.375" y="4475.715"/> </glyph> <glyph class="state variable" id="_d1f366e7-e790-48e5-80f1-060300312a62"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="13715.375" y="4475.715"/> </glyph> <glyph class="state variable" id="_08dc9d64-a2b8-4205-b997-6a05381c58ec"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13645.375" y="4495.5"/> </glyph> <glyph class="state variable" id="_37317e86-a8e5-430e-aa70-aa0d52779008"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="13635.867" y="4475.5"/> </glyph> <glyph class="state variable" id="_89b59828-31bb-4ee5-b02d-544c3874d3cc"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="13715.375" y="4475.715"/> </glyph> <glyph class="state variable" id="_5607aad0-b2be-4e51-b93e-699e8c94786c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13645.375" y="4487.216"/> </glyph> <glyph class="state variable" id="_5d94e4d3-7884-4b85-940c-91fecebd3d24"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="13715.375" y="4475.715"/> </glyph> <glyph class="state variable" id="_32a235fe-c92f-4c18-a174-6f2dbfb5e660"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13645.375" y="4495.5"/> </glyph> <glyph class="state variable" id="_41d0fbbd-2132-4355-b2a1-b33be83872e4"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="13714.757" y="4515.5"/> </glyph> <glyph class="state variable" id="_14a7effb-9576-48a9-a3b2-0ba6739b7cc2"> <state value="Ac" variable="K345"/> <bbox w="40.0" h="10.0" x="13710.375" y="4475.715"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s472_wca1_wca3_sa353"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: E1A binding protein p300 HUGO:EP300 HGNC:3373 ENTREZ:2033 UNIPROT:Q09472 GENECARDS:EP300 REACTOME:61164 KEGG:2033 ATLASONC:P300ID97 WIKI:EP300 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:HIF1 MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="p300*"/> <bbox w="80.0" h="40.0" x="13569.4375" y="4486.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s473_wca1_wca3_sa354"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Kruppel-like factor 8 HUGO:KLF8 HGNC:6351 ENTREZ:11279 UNIPROT:O95600 GENECARDS:KLF8 KEGG:11279 ATLASONC:GC_KLF8 WIKI:KLF8 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="KLF8"/> <bbox w="80.0" h="40.0" x="13570.5625" y="4442.0"/> <glyph class="state variable" id="_b99bb851-7d10-4822-8b85-8715cb7068ae"> <state value="Ac" variable="K95"/> <bbox w="35.0" h="10.0" x="13633.0625" y="4475.379"/> </glyph> <glyph class="state variable" id="_9f6acc05-f1df-4bae-8d6f-6427c62ac4e9"> <state value="Ac" variable="K67"/> <bbox w="35.0" h="10.0" x="13553.0625" y="4437.93"/> </glyph> <glyph class="state variable" id="_3fa61538-5033-4f54-83b3-978bb05e6271"> <state value="Ac" variable="K93"/> <bbox w="35.0" h="10.0" x="13631.911" y="4437.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s475_wca1_wca3_sa355"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>TCF family: tcf-1, lef-1, tcf-3, tcf-4 PMID:11266540 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 transcription factor 7-like 1 (T-cell specific HMG-box) TCF3 HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 transcription factor 7-like 2 (T-cell specific HMG-box) TCF4 HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end</body> </html> </notes> <label text="LEF_TCF*"/> <bbox w="80.0" h="40.0" x="13657.75" y="4522.5"/> <glyph class="state variable" id="_0f2087b1-cfb7-445a-8a96-b675010d6cb1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13732.75" y="4518.378"/> </glyph> <glyph class="state variable" id="_ac3bd982-7fe7-41db-b689-38a47d13b2a0"> <state value="" variable="S40"/> <bbox w="25.0" h="10.0" x="13725.25" y="4554.1143"/> </glyph> <glyph class="state variable" id="_fd88d729-25d0-421f-badb-6d153192f2e0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13732.75" y="4537.5"/> </glyph> <glyph class="state variable" id="_760420c1-926e-48b1-a11d-2c00bfded96a"> <state value="" variable="S166"/> <bbox w="30.0" h="10.0" x="13643.242" y="4517.5"/> </glyph> <glyph class="state variable" id="_2501fee0-76f3-4ccb-9126-5b6604c1b75e"> <state value="" variable="T155"/> <bbox w="30.0" h="10.0" x="13642.75" y="4557.222"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_wca3_s474_wca1_wca3_sa356"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: WNT responsive element References_end</body> </html> </notes> <label text="WRE*"/> <bbox w="70.0" h="25.0" x="13661.25" y="4569.5"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s491_wca1_wca3_csa59" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL9:CTBP*:KLF4:LEF_TCF*:PYGO*:WRE*:_beta_-Catenin* Identifiers_end References_begin: s_wca3_re127:(MAP:survival) PMID:19901072 PMID:19751731 s_wca3_re7(MAP:survival): The transcription complex containing P300 initiates transcription of genes that are involved in differentiation. PMID:20920541 The repressor complex is is by default present on the enhancers of wnt-target genes PMID:16510874 s_wca3_re125(MAP:survival): CBP-mediated transcription effects genes that are involved in stemm cell or progenitor cell maintenance and proliferation Repressor complex is default present on the enhance of wnt-target genes References_end</body> </html> </notes> <label text="BCL9:CTBP*:KLF4:LEF_TCF*:PYGO*:WRE*:β-Catenin*"/> <bbox w="189.0" h="202.0" x="13972.214" y="3813.5"/> <glyph class="macromolecule" id="wca1_wca3_s485_wca1_wca3_sa361"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Kruppel-like factor 4 (gut) HUGO:KLF4 HGNC:6348 ENTREZ:9314 UNIPROT:O43474 GENECARDS:KLF4 REACTOME:58119 KEGG:9314 ATLASONC:KLF4ID44316ch9q31 WIKI:KLF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="KLF4"/> <bbox w="80.0" h="40.0" x="13982.25" y="3824.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s486_wca1_wca3_sa362"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: B-cell CLL/lymphoma 9 HUGO:BCL9 HGNC:1008 ENTREZ:607 UNIPROT:O00512 GENECARDS:BCL9 KEGG:607 ATLASONC:BCL9ID466 WIKI:BCL9 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BCL9"/> <bbox w="80.0" h="40.0" x="14066.214" y="3868.2388"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s487_wca1_wca3_sa363"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: pygopus homolog 1 (Drosophila) HUGO:PYGO1 HGNC:30256 ENTREZ:26108 UNIPROT:Q9Y3Y4 GENECARDS:PYGO1 WIKI:PYGO1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PYGO*"/> <bbox w="80.0" h="40.0" x="14066.214" y="3823.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s488_wca1_wca3_sa364"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="14066.214" y="3915.5"/> <glyph class="state variable" id="_81a360ff-da80-4c55-9726-daee409bc879"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="14093.618" y="3950.5"/> </glyph> <glyph class="state variable" id="_9d62c4f0-e520-4598-bc0b-7801c62646f6"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="14133.096" y="3950.5"/> </glyph> <glyph class="state variable" id="_5d1e1893-62e6-4586-8933-bbeeb444717f"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="14133.714" y="3910.7148"/> </glyph> <glyph class="state variable" id="_669c8f58-a20e-42dc-868e-af9d540813b2"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="14093.746" y="3910.5"/> </glyph> <glyph class="state variable" id="_6d34d566-07bb-4e74-8cd6-33a12b201414"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="14054.206" y="3910.5"/> </glyph> <glyph class="state variable" id="_036029c0-83dd-4435-8f7c-f869be215d06"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="14053.714" y="3950.2224"/> </glyph> <glyph class="state variable" id="_4997b93b-a9a5-437f-be90-4e68ccab29f5"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="14131.214" y="3910.7148"/> </glyph> <glyph class="state variable" id="_9729c237-9cbd-414f-ab1b-6a46506b4bc1"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="14131.214" y="3910.7148"/> </glyph> <glyph class="state variable" id="_219fe4ac-a82d-4d77-95aa-94f95c10dd07"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14061.214" y="3930.5"/> </glyph> <glyph class="state variable" id="_c9bd0a76-e69d-4f54-9187-ef195e57a02a"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="14051.706" y="3910.5"/> </glyph> <glyph class="state variable" id="_c9670007-23b3-4a7c-b276-cfbb6ba5e82b"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="14131.214" y="3910.7148"/> </glyph> <glyph class="state variable" id="_da8e5c7e-3659-48d6-bd78-a1c3e12cdfb8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14061.214" y="3922.2158"/> </glyph> <glyph class="state variable" id="_27d30340-c68e-4e94-b1d8-cb835c571c5c"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="14131.214" y="3910.7148"/> </glyph> <glyph class="state variable" id="_3061ada3-b71d-4897-b260-079e0cca6542"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14061.214" y="3930.5"/> </glyph> <glyph class="state variable" id="_2666d98c-2e72-471f-867a-57baeba95558"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="14130.596" y="3950.5"/> </glyph> <glyph class="state variable" id="_caa08132-9040-4179-9250-37e9fb4fec52"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="14131.214" y="3910.7148"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s489_wca1_wca3_sa365"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>TCF family: tcf-1, lef-1, tcf-3, tcf-4 PMID:11266540 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 transcription factor 7-like 1 (T-cell specific HMG-box) TCF3 HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 transcription factor 7-like 2 (T-cell specific HMG-box) TCF4 HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end</body> </html> </notes> <label text="LEF_TCF*"/> <bbox w="80.0" h="40.0" x="13981.875" y="3868.1511"/> <glyph class="state variable" id="_294b999d-97ff-4cac-a8de-119e87a2f6f1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14056.875" y="3864.029"/> </glyph> <glyph class="state variable" id="_2be5b82e-8ef6-4d69-93b8-5133b8ccec96"> <state value="" variable="S40"/> <bbox w="25.0" h="10.0" x="14049.375" y="3899.7651"/> </glyph> <glyph class="state variable" id="_eaeca244-53f8-45f4-ac82-20b90f07757b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14056.875" y="3883.1511"/> </glyph> <glyph class="state variable" id="_2ac82c69-ae38-4830-a08a-1dc0848b0c0c"> <state value="" variable="S166"/> <bbox w="30.0" h="10.0" x="13967.367" y="3863.1511"/> </glyph> <glyph class="state variable" id="_90b287f1-3d55-4de2-a711-06f383105b7e"> <state value="" variable="T155"/> <bbox w="30.0" h="10.0" x="13966.875" y="3902.8735"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s490_wca1_wca3_sa366"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: C-terminal binding protein 1 HUGO:CTBP1 HGNC:2494 ENTREZ:1487 UNIPROT:Q13363 GENECARDS:CTBP1 KEGG:1487 ATLASONC:GC_CTBP1 WIKI:CTBP1 C-terminal binding protein 2 HUGO:CTBP2 HGNC:2495 ENTREZ:1488 UNIPROT:P56545 GENECARDS:CTBP2 ATLASONC:GC_CTBP2 WIKI:CTBP2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTBP*"/> <bbox w="80.0" h="40.0" x="13982.25" y="3916.0"/> <glyph class="state variable" id="_5d67324c-1cad-48b5-86ec-44a145840111"> <state value="" variable="S422"/> <bbox w="30.0" h="10.0" x="14047.25" y="3911.2148"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_wca3_s492_wca1_wca3_sa367"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: WNT responsive element References_end</body> </html> </notes> <label text="WRE*"/> <bbox w="70.0" h="25.0" x="13984.0" y="3955.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s522_wca1_wca3_csa61" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AXIN2:MIR34A Identifiers_end References_begin: s_wca3_re132(MAP:survival): Actually the whole MIR-34 family targets AXIN2 PMID:22421157 References_end</body> </html> </notes> <label text="AXIN2:MIR34A"/> <bbox w="100.0" h="120.0" x="13508.0" y="4937.0"/> <glyph class="nucleic acid feature" id="wca1_wca3_s524_wca1_wca3_sa379"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="AXIN2"/> <bbox w="90.0" h="25.0" x="13510.0" y="4963.0"/> <glyph class="unit of information" id="_0961027f-73e0-4333-b667-b66ab3f50e55"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="13545.0" y="4958.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_wca3_s523_wca1_wca3_sa380"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 34a HUGO:MIR34A HGNC:31635 ENTREZ:407040 GENECARDS:MIR34A KEGG:407040 ATLASONC:GC_MIR34A WIKI:MIR34A Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR34A"/> <bbox w="90.0" h="25.0" x="13509.0" y="4991.0"/> <glyph class="unit of information" id="_533f6839-826f-4f6a-b6af-0a396f01155a"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="13539.0" y="4986.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s536_wca1_wca3_csa62" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:SIX3:TLE* Identifiers_end References_begin: s_wca3_re135:(MAP:survival) PMID:12050133 PPMID:12441302 s_wca3_re45:(MAP:survival) PMID:20710043 References_end</body> </html> </notes> <label text="SIX3:TLE*"/> <bbox w="100.0" h="120.0" x="13894.0" y="5182.0"/> <glyph class="macromolecule" id="wca1_wca3_s537_wca1_wca3_sa385"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: SIX homeobox 3 "holoprosencephaly 2 alobar or semilobar" HPE2 "sine oculis homeobox homolog 3 (Drosophila)" HUGO:SIX3 HGNC:10889 ENTREZ:6496 UNIPROT:O95343 GENECARDS:SIX3 KEGG:6496 ATLASONC:GC_SIX3 WIKI:SIX3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="SIX3"/> <bbox w="80.0" h="40.0" x="13904.0" y="5240.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s539_wca1_wca3_sa386"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transducin-like enhancer of split 1 (E(sp1) homolog Drosophila) "transducin-like enhancer of split 1 homolog of Drosophila E(sp1)" HUGO:TLE1 HGNC:11837 ENTREZ:7088 UNIPROT:Q04724 GENECARDS:TLE1 REACTOME:66083 KEGG:7088 ATLASONC:GC_TLE1 WIKI:TLE1 transducin-like enhancer of split 2 (E(sp1) homolog Drosophila) HUGO:TLE2 HGNC:11838 ENTREZ:7089 UNIPROT:Q04725 GENECARDS:TLE2 REACTOME:66085 KEGG:7089 WIKI:TLE2 transducin-like enhancer of split 3 (E(sp1) homolog Drosophila) HUGO:TLE3 HGNC:11839 ENTREZ:7090 UNIPROT:Q04726 GENECARDS:TLE3 REACTOME:405165 KEGG:7090 ATLASONC:GC_TLE3 WIKI:TLE3 transducin-like enhancer of split 4 (E(sp1) homolog Drosophila) HUGO:TLE4 HGNC:11840 ENTREZ:7091 UNIPROT:Q04727 GENECARDS:TLE4 REACTOME:66089 KEGG:7091 WIKI:TLE4 amino-terminal enhancer of split GRG5 TLE5 HUGO:AES HGNC:307 ENTREZ:166 UNIPROT:Q08117 GENECARDS:AES KEGG:166 ATLASONC:GC_AES WIKI:AES transducin-like enhancer of split 6 (E(sp1) homolog Drosophila) HUGO:TLE6 HGNC:30788 ENTREZ:79816 UNIPROT:Q9H808 GENECARDS:TLE6 KEGG:79816 ATLASONC:GC_TLE6 WIKI:TLE6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: References_begin non-DNA binding transcription factor PMID:20925119 References-end References_end</body> </html> </notes> <label text="TLE*"/> <bbox w="80.0" h="40.0" x="13903.25" y="5198.0"/> <glyph class="state variable" id="_665a51e5-3ec5-4f8c-880f-7061d4d51cb7"> <state value="" variable="S239"/> <bbox w="30.0" h="10.0" x="13888.742" y="5193.0"/> </glyph> <glyph class="state variable" id="_fa2ad22d-5746-4e2a-84fc-6ab9cf8a9d11"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13978.25" y="5193.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s543_wca1_wca3_csa63" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AES:TLE* Identifiers_end References_begin: s_wca3_re138:(MAP:survival) PMID:20925119 References_end</body> </html> </notes> <label text="AES:TLE*"/> <bbox w="100.0" h="120.0" x="14473.0" y="3802.0"/> <glyph class="macromolecule" id="wca1_wca3_s545_wca1_wca3_sa390"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: amino-terminal enhancer of split HUGO:AES HGNC:307 ENTREZ:166 UNIPROT:Q08117 GENECARDS:AES KEGG:166 ATLASONC:GC_AES WIKI:AES Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="AES"/> <bbox w="80.0" h="40.0" x="14483.25" y="3863.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s544_wca1_wca3_sa391"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transducin-like enhancer of split 1 (E(sp1) homolog Drosophila) "transducin-like enhancer of split 1 homolog of Drosophila E(sp1)" HUGO:TLE1 HGNC:11837 ENTREZ:7088 UNIPROT:Q04724 GENECARDS:TLE1 REACTOME:66083 KEGG:7088 ATLASONC:GC_TLE1 WIKI:TLE1 transducin-like enhancer of split 2 (E(sp1) homolog Drosophila) HUGO:TLE2 HGNC:11838 ENTREZ:7089 UNIPROT:Q04725 GENECARDS:TLE2 REACTOME:66085 KEGG:7089 WIKI:TLE2 transducin-like enhancer of split 3 (E(sp1) homolog Drosophila) HUGO:TLE3 HGNC:11839 ENTREZ:7090 UNIPROT:Q04726 GENECARDS:TLE3 REACTOME:405165 KEGG:7090 ATLASONC:GC_TLE3 WIKI:TLE3 transducin-like enhancer of split 4 (E(sp1) homolog Drosophila) HUGO:TLE4 HGNC:11840 ENTREZ:7091 UNIPROT:Q04727 GENECARDS:TLE4 REACTOME:66089 KEGG:7091 WIKI:TLE4 amino-terminal enhancer of split GRG5 TLE5 HUGO:AES HGNC:307 ENTREZ:166 UNIPROT:Q08117 GENECARDS:AES KEGG:166 ATLASONC:GC_AES WIKI:AES transducin-like enhancer of split 6 (E(sp1) homolog Drosophila) HUGO:TLE6 HGNC:30788 ENTREZ:79816 UNIPROT:Q9H808 GENECARDS:TLE6 KEGG:79816 ATLASONC:GC_TLE6 WIKI:TLE6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: References_begin non-DNA binding transcription factor PMID:20925119 References-end References_end</body> </html> </notes> <label text="TLE*"/> <bbox w="80.0" h="40.0" x="14483.25" y="3818.0"/> <glyph class="state variable" id="_e34e236f-a88f-4a6b-867f-e9374a28abd4"> <state value="" variable="S239"/> <bbox w="30.0" h="10.0" x="14468.742" y="3813.0"/> </glyph> <glyph class="state variable" id="_576009a5-0839-436a-9213-3d01bd0fd153"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14558.25" y="3813.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s552_wca1_wca3_csa64" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DVL*:HIPK1 Identifiers_end References_begin: s_wca3_re139:(MAP:survival) PMID:19183803 References_end</body> </html> </notes> <label text="DVL*:HIPK1"/> <bbox w="100.0" h="120.0" x="14848.0" y="4238.0"/> <glyph class="macromolecule" id="wca1_wca3_s554_wca1_wca3_sa394"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: homeodomain interacting protein kinase 1 HUGO:HIPK1 HGNC:19006 ENTREZ:204851 UNIPROT:Q86Z02 GENECARDS:HIPK1 KEGG:204851 ATLASONC:GC_HIPK1 WIKI:HIPK1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HIPK1"/> <bbox w="80.0" h="40.0" x="14859.0" y="4245.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s553_wca1_wca3_sa395"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="14859.0" y="4289.0"/> <glyph class="state variable" id="_6c0a02fb-d998-4aa3-8f07-07ce84001da8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14934.0" y="4284.0"/> </glyph> <glyph class="state variable" id="_2a9bf8d6-93d3-4dc2-8701-30c6664554a7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14854.0" y="4284.0"/> </glyph> <glyph class="state variable" id="_61a4b1d8-743c-48a1-bc4b-b040b5a7e8f6"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="14923.382" y="4324.0"/> </glyph> <glyph class="state variable" id="_903a156c-7aad-4b32-be9a-0c9f739d50a8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14854.0" y="4284.0"/> </glyph> <glyph class="state variable" id="_52146144-021e-4609-942f-d413fe5e383a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14934.0" y="4284.0"/> </glyph> <glyph class="state variable" id="_4000be1a-17ce-4011-b14e-925a4d6a4d86"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14933.634" y="4284.0"/> </glyph> <glyph class="state variable" id="_b872fe0a-e5ea-434f-8183-d263f056ab32"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14934.0" y="4324.0"/> </glyph> <glyph class="state variable" id="_52cad0ac-9265-4199-bd93-103862fe1c2e"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="14844.0" y="4323.722"/> </glyph> <glyph class="state variable" id="_8870ed97-f301-4f18-8e3d-8e00c783b476"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14854.0" y="4324.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s571_wca1_wca3_csa65" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CTBP*:HIPK2:LEF_TCF*:_beta_-Catenin* Identifiers_end References_begin: s_wca3_re144(MAP:survival): This complex does not contain HDAC but do contain LEF1 PMID:17666529 s_wca3_re116(MAP:survival): PMID:22761862 Swi/SNF complex PMID:22290435 NuRD complex: b-catenin/CTBP/Hipk2/LEF1 complex References_end</body> </html> </notes> <label text="CTBP*:HIPK2:LEF_TCF*:β-Catenin*"/> <bbox w="194.0" h="118.0" x="13183.0" y="3907.0"/> <glyph class="macromolecule" id="wca1_wca3_s569_wca1_wca3_sa400"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: C-terminal binding protein 1 HUGO:CTBP1 HGNC:2494 ENTREZ:1487 UNIPROT:Q13363 GENECARDS:CTBP1 KEGG:1487 ATLASONC:GC_CTBP1 WIKI:CTBP1 C-terminal binding protein 2 HUGO:CTBP2 HGNC:2495 ENTREZ:1488 UNIPROT:P56545 GENECARDS:CTBP2 ATLASONC:GC_CTBP2 WIKI:CTBP2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTBP*"/> <bbox w="80.0" h="40.0" x="13196.75" y="3920.0"/> <glyph class="state variable" id="_f1199943-4548-4157-bdc8-b52665932495"> <state value="" variable="S422"/> <bbox w="30.0" h="10.0" x="13261.75" y="3915.2148"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s568_wca1_wca3_sa401"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: homeodomain interacting protein kinase 2 "homeodomain-interacting protein kinase 2" HUGO:HIPK2 HGNC:14402 ENTREZ:28996 UNIPROT:Q9H2X6 GENECARDS:HIPK2 KEGG:28996 ATLASONC:HIPK2ID40824ch7q34 WIKI:HIPK2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: HIPK2 is pre-dominantly present in the nucleus PMID:18974774 References_end Identifiers_begin: homeodomain interacting protein kinase 2 "homeodomain-interacting protein kinase 2" HUGO:HIPK2 HGNC:14402 ENTREZ:28996 UNIPROT:Q9H2X6 GENECARDS:HIPK2 KEGG:28996 ATLASONC:HIPK2ID40824ch7q34 WIKI:HIPK2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: HIPK2 is pre-dominantly present in the nucleus PMID:18974774 References_end</body> </html> </notes> <label text="HIPK2"/> <bbox w="80.0" h="40.0" x="13196.75" y="3964.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s570_wca1_wca3_sa402"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="13280.75" y="3920.0"/> <glyph class="state variable" id="_2d98e470-7e34-4b03-a571-ab056a4f9abe"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="13308.154" y="3955.0"/> </glyph> <glyph class="state variable" id="_23a45d89-8ee7-4aeb-a043-ce4971d930c8"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="13347.632" y="3955.0"/> </glyph> <glyph class="state variable" id="_995424e1-bbfb-49a1-98e7-c318b5982e18"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="13348.25" y="3915.2148"/> </glyph> <glyph class="state variable" id="_4eae4aeb-62b4-45b4-b4b5-d46a0e8d7627"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="13308.282" y="3915.0"/> </glyph> <glyph class="state variable" id="_6044a757-9c11-41bb-972b-1d3613da6829"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="13268.742" y="3915.0"/> </glyph> <glyph class="state variable" id="_ce777cc5-dedd-458f-956e-f54b080d2dd2"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="13268.25" y="3954.7224"/> </glyph> <glyph class="state variable" id="_87773fa9-cad7-4270-8990-0c8cf094956f"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="13345.75" y="3915.2148"/> </glyph> <glyph class="state variable" id="_30251591-51df-4af7-bb7a-339c9150a270"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="13345.75" y="3915.2148"/> </glyph> <glyph class="state variable" id="_d6bd7501-c823-4e4c-82f5-f08ff3861b93"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13275.75" y="3935.0"/> </glyph> <glyph class="state variable" id="_4fcb4475-337a-49a6-9a78-1c06d6b30129"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="13266.242" y="3915.0"/> </glyph> <glyph class="state variable" id="_26e1a19d-98ba-4ad2-8ff6-89acb255515c"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="13345.75" y="3915.2148"/> </glyph> <glyph class="state variable" id="_aa2be62e-522c-42bd-a402-886ea629dccf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13275.75" y="3926.7158"/> </glyph> <glyph class="state variable" id="_e20ade2e-2efb-4c10-8f0f-d8db029dfeb6"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="13345.75" y="3915.2148"/> </glyph> <glyph class="state variable" id="_f656442e-eccf-4e0f-9f4e-82962bf76924"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13275.75" y="3935.0"/> </glyph> <glyph class="state variable" id="_e67fc0c6-82d4-4b08-842f-afb545675234"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="13345.132" y="3955.0"/> </glyph> <glyph class="state variable" id="_ed65a0f9-98db-4a02-9cd1-3c73759457fa"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="13345.75" y="3915.2148"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s567_wca1_wca3_sa403"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>TCF family: tcf-1, lef-1, tcf-3, tcf-4 PMID:11266540 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 transcription factor 7-like 1 (T-cell specific HMG-box) TCF3 HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 transcription factor 7-like 2 (T-cell specific HMG-box) TCF4 HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end</body> </html> </notes> <label text="LEF_TCF*"/> <bbox w="80.0" h="40.0" x="13280.75" y="3964.0"/> <glyph class="state variable" id="_653f2ab8-9889-4254-bb67-e7832b4e2336"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13355.75" y="3959.878"/> </glyph> <glyph class="state variable" id="_8a156321-3e4b-4014-964a-0b30d9d2a3db"> <state value="" variable="S40"/> <bbox w="25.0" h="10.0" x="13348.25" y="3995.614"/> </glyph> <glyph class="state variable" id="_2b19b88f-71e9-4f16-86ca-72ed1bbffed3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13355.75" y="3979.0"/> </glyph> <glyph class="state variable" id="_bd0f8879-39fa-4bbd-af2e-fb40ff791090"> <state value="" variable="S166"/> <bbox w="30.0" h="10.0" x="13266.242" y="3959.0"/> </glyph> <glyph class="state variable" id="_cae4712c-54ea-4c6e-a5af-745ad7dda40d"> <state value="" variable="T155"/> <bbox w="30.0" h="10.0" x="13265.75" y="3998.7224"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s651_wca1_wca3_csa69" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DKK1:MIR373 Identifiers_end References_begin: s_wca3_re162:(MAP:survival) PMID:22020335 References_end</body> </html> </notes> <label text="DKK1:MIR373"/> <bbox w="99.0" h="94.0" x="13516.0" y="5067.0"/> <glyph class="nucleic acid feature" id="wca1_wca3_s653_wca1_wca3_sa451"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: dickkopf 1 homolog (Xenopus laevis) "dickkopf (Xenopus laevis) homolog 1" HUGO:DKK1 HGNC:2891 ENTREZ:22943 UNIPROT:O94907 GENECARDS:DKK1 KEGG:22943 ATLASONC:DKK1ID44007ch10q11 WIKI:DKK1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="DKK1"/> <bbox w="90.0" h="25.0" x="13522.0" y="5083.0"/> <glyph class="unit of information" id="_e2215c22-3e1b-44df-bb02-bb334b9f0b4b"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="13557.0" y="5078.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_wca3_s652_wca1_wca3_sa453"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 373 HUGO:MIR373 HGNC:31787 ENTREZ:442918 GENECARDS:MIR373 KEGG:442918 ATLASONC:GC_MIR373 WIKI:MIR373 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR373"/> <bbox w="90.0" h="25.0" x="13521.0" y="5110.0"/> <glyph class="unit of information" id="_34bb404e-6497-4d2e-ac83-f3b13a71c2f5"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="13551.0" y="5105.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s654_wca1_wca3_csa68" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DKK1:MIR372 Identifiers_end References_begin: s_wca3_re161:(MAP:survival) PMID:22020335 References_end</body> </html> </notes> <label text="DKK1:MIR372"/> <bbox w="98.0" h="94.0" x="13389.0" y="5069.0"/> <glyph class="nucleic acid feature" id="wca1_wca3_s650_wca1_wca3_sa450"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: dickkopf 1 homolog (Xenopus laevis) "dickkopf (Xenopus laevis) homolog 1" HUGO:DKK1 HGNC:2891 ENTREZ:22943 UNIPROT:O94907 GENECARDS:DKK1 KEGG:22943 ATLASONC:DKK1ID44007ch10q11 WIKI:DKK1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="DKK1"/> <bbox w="90.0" h="25.0" x="13390.5" y="5081.0"/> <glyph class="unit of information" id="_64218743-e3e5-4849-a09f-499b053c3d1f"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="13425.5" y="5076.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_wca3_s649_wca1_wca3_sa452"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 372 HUGO:MIR372 HGNC:31786 ENTREZ:442917 GENECARDS:MIR372 KEGG:442917 ATLASONC:GC_MIR372 WIKI:MIR372 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR372"/> <bbox w="90.0" h="25.0" x="13390.5" y="5110.0"/> <glyph class="unit of information" id="_55a0bb72-2835-4c33-9a51-755d01681b05"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="13420.5" y="5105.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s677_wca1_wca3_csa70" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DVL*:JUN Identifiers_end References_begin: s_wca3_re109:(MAP:survival) PMID:12711682 PMID:15834423 PMID:16510874 PMID:15327769 PMID:16547505 s_wca3_re169(MAP:survival): Upon WNT3a stimulation formation complex DVL with c-jun PMID:18347071 References_end</body> </html> </notes> <label text="DVL*:JUN"/> <bbox w="100.0" h="120.0" x="14613.0" y="4406.0"/> <glyph class="macromolecule" id="wca1_wca3_s679_wca1_wca3_sa464"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> </notes> <label text="JUN"/> <bbox w="80.0" h="40.0" x="14623.25" y="4417.0"/> <glyph class="state variable" id="_9367768c-ecf7-4cab-ab41-47c880093092"> <state value="" variable="S63"/> <bbox w="25.0" h="10.0" x="14611.242" y="4412.0"/> </glyph> <glyph class="state variable" id="_5bdeeb40-8ded-4bd4-9d56-e242a1abd3fc"> <state value="" variable="S73"/> <bbox w="25.0" h="10.0" x="14650.782" y="4412.0"/> </glyph> <glyph class="state variable" id="_3e31355c-da70-4928-98d8-3751971517ee"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14618.25" y="4432.0"/> </glyph> <glyph class="state variable" id="_0b2c6105-9fda-4f38-b890-3ba22575aa59"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14615.75" y="4412.0"/> </glyph> <glyph class="state variable" id="_afe57f37-a204-4dac-a86c-6bb48c6fcccb"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14615.75" y="4452.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s678_wca1_wca3_sa465"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="14623.25" y="4462.0"/> <glyph class="state variable" id="_5348733f-969f-4be2-add6-8590d43d2a9d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14698.25" y="4457.0"/> </glyph> <glyph class="state variable" id="_17a4d8fd-9d72-46e5-9fd1-abc8e8415a7c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14618.25" y="4457.0"/> </glyph> <glyph class="state variable" id="_a3231308-3106-4cdc-8873-e2f94fc3e216"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="14687.632" y="4497.0"/> </glyph> <glyph class="state variable" id="_e2b9f981-f38f-4b8a-b932-80c45d5e2698"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14618.25" y="4457.0"/> </glyph> <glyph class="state variable" id="_d64a4a95-e749-4e4d-bca4-8fad90627cde"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14698.25" y="4457.0"/> </glyph> <glyph class="state variable" id="_8111ac7a-a4fc-46b7-9259-c4a491c0f4ca"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14697.884" y="4457.0"/> </glyph> <glyph class="state variable" id="_e8dc887b-a9e5-4312-8225-d83390967b64"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14698.25" y="4497.0"/> </glyph> <glyph class="state variable" id="_0b1515f7-78d2-4910-ba10-b3c744d423b4"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="14608.25" y="4496.722"/> </glyph> <glyph class="state variable" id="_bb76cdd7-515b-45bf-8c0c-f9255930c8d7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14618.25" y="4497.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s687_wca1_wca3_csa71" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL9:DVL*:JUN:PYGO*:_beta_-Catenin*:p300* Identifiers_end References_begin: s_wca3_re170:(MAP:survival) PMID:18347071 s_wca3_re6(MAP:survival): PMID:16169192 B-catenin competes with TLE for Lef-1 PMID:15768032 CBP-and P300-mediated transcription different cell fates PMID:20530697 (phosphorylated) C-JUN can bind to TCF4 PMID:18347071 PMID:16007074 References_end</body> </html> </notes> <label text="BCL9:DVL*:JUN:PYGO*:β-Catenin*:p300*"/> <bbox w="105.0" h="303.0" x="13498.25" y="4125.5"/> <glyph class="macromolecule" id="wca1_wca3_s681_wca1_wca3_sa466"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: B-cell CLL/lymphoma 9 HUGO:BCL9 HGNC:1008 ENTREZ:607 UNIPROT:O00512 GENECARDS:BCL9 KEGG:607 ATLASONC:BCL9ID466 WIKI:BCL9 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BCL9"/> <bbox w="80.0" h="40.0" x="13511.3125" y="4214.25"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s682_wca1_wca3_sa467"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: pygopus homolog 1 (Drosophila) HUGO:PYGO1 HGNC:30256 ENTREZ:26108 UNIPROT:Q9Y3Y4 GENECARDS:PYGO1 WIKI:PYGO1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PYGO*"/> <bbox w="80.0" h="40.0" x="13511.3125" y="4174.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s683_wca1_wca3_sa468"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="13510.8125" y="4252.5"/> <glyph class="state variable" id="_538647de-3a93-46db-9ee2-3e5fc0f73f71"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="13538.217" y="4287.5"/> </glyph> <glyph class="state variable" id="_490801e6-cb09-46d1-abdb-20c575f19413"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="13577.694" y="4287.5"/> </glyph> <glyph class="state variable" id="_b896436f-7a4e-41ad-b973-ae5c93e77456"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="13578.3125" y="4247.715"/> </glyph> <glyph class="state variable" id="_e1f6afb0-9c74-4eda-915f-db0135c4c44f"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="13538.345" y="4247.5"/> </glyph> <glyph class="state variable" id="_ee0c712d-d51a-4473-84d7-35b07b04bb75"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="13498.805" y="4247.5"/> </glyph> <glyph class="state variable" id="_3b353990-5abc-4d42-ac8b-4553fa24e855"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="13498.3125" y="4287.222"/> </glyph> <glyph class="state variable" id="_edb4ea7f-7c6b-4751-92eb-9f2c0d2b0ac5"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="13575.8125" y="4247.715"/> </glyph> <glyph class="state variable" id="_75442682-3816-4751-9966-bcf17d8bb2fa"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="13575.8125" y="4247.715"/> </glyph> <glyph class="state variable" id="_a2e66e9e-8e8a-4eeb-b7e2-bc5476eca54b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13505.8125" y="4267.5"/> </glyph> <glyph class="state variable" id="_c5798df5-337b-47a2-91b2-903ce2a2a2ff"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="13496.305" y="4247.5"/> </glyph> <glyph class="state variable" id="_194bd960-b10a-490f-9366-5f150d3a25c7"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="13575.8125" y="4247.715"/> </glyph> <glyph class="state variable" id="_6e28df26-a69f-4f82-aac8-2183f95bc1ea"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13505.8125" y="4259.216"/> </glyph> <glyph class="state variable" id="_012377cd-2758-44e5-97d1-a1e595953a62"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="13575.8125" y="4247.715"/> </glyph> <glyph class="state variable" id="_e4b6d937-70e2-49d8-8264-61843de4937a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13505.8125" y="4267.5"/> </glyph> <glyph class="state variable" id="_922feb55-102c-4da6-b65b-28b12585984f"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="13575.194" y="4287.5"/> </glyph> <glyph class="state variable" id="_5324b6d7-e5e5-4731-9e72-a782f6f372aa"> <state value="Ac" variable="K345"/> <bbox w="40.0" h="10.0" x="13570.8125" y="4247.715"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s684_wca1_wca3_sa469"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: E1A binding protein p300 HUGO:EP300 HGNC:3373 ENTREZ:2033 UNIPROT:Q09472 GENECARDS:EP300 REACTOME:61164 KEGG:2033 ATLASONC:P300ID97 WIKI:EP300 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:HIF1 MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="p300*"/> <bbox w="80.0" h="40.0" x="13510.875" y="4133.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s686_wca1_wca3_sa470"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> </notes> <label text="JUN"/> <bbox w="80.0" h="40.0" x="13511.0" y="4300.5"/> <glyph class="state variable" id="_5f9f7302-3512-40ca-b4c4-d2b9a1caee9e"> <state value="" variable="S63"/> <bbox w="25.0" h="10.0" x="13498.992" y="4295.5"/> </glyph> <glyph class="state variable" id="_e1be224c-c969-465e-b5d6-ba0cb4eb4da8"> <state value="" variable="S73"/> <bbox w="25.0" h="10.0" x="13538.532" y="4295.5"/> </glyph> <glyph class="state variable" id="_902071be-2524-43e4-b8c7-f856bd5f0a14"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13506.0" y="4315.5"/> </glyph> <glyph class="state variable" id="_4dc1b75d-5009-449d-b469-e7c66dec7668"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="13503.5" y="4295.5"/> </glyph> <glyph class="state variable" id="_983ddb2e-968d-4e05-a54a-8a050773f81b"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="13503.5" y="4335.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s685_wca1_wca3_sa471"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="13511.0" y="4345.5"/> <glyph class="state variable" id="_194461be-f75b-41cf-88f2-1127ea4a7c78"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13586.0" y="4340.5"/> </glyph> <glyph class="state variable" id="_79db4059-faae-429a-ba70-9dbb773a2c7f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13506.0" y="4340.5"/> </glyph> <glyph class="state variable" id="_9fcf4f33-d7e2-48f5-9031-cde57889cf09"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="13575.382" y="4380.5"/> </glyph> <glyph class="state variable" id="_b2fc1435-a719-494d-8a1e-a3ab3e92aba5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13506.0" y="4340.5"/> </glyph> <glyph class="state variable" id="_714d7ea9-b607-4838-a2fa-2a3ad59f33cf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13586.0" y="4340.5"/> </glyph> <glyph class="state variable" id="_19a090a0-c6d0-4b9d-8fe4-75ed3c14653f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13585.634" y="4340.5"/> </glyph> <glyph class="state variable" id="_eacd54cb-2139-4e4b-b28f-e4d8a8cbf554"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13586.0" y="4380.5"/> </glyph> <glyph class="state variable" id="_a78a0699-de3d-4ce2-b885-6bebd37ecc99"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="13496.0" y="4380.222"/> </glyph> <glyph class="state variable" id="_4facb7ca-cceb-4ab5-aff4-1a74af2fd65f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13506.0" y="4380.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s696_wca1_wca3_csa72" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL9:CBP*:DVL*:JUN:PYGO*:_beta_-Catenin* Identifiers_end References_begin: s_wca3_re12(MAP:survival): CBP-and P300-mediated transcription different cell fates PMID:20530697 References_end</body> </html> </notes> <label text="BCL9:CBP*:DVL*:JUN:PYGO*:β-Catenin*"/> <bbox w="118.0" h="316.0" x="14983.17" y="4033.5"/> <glyph class="macromolecule" id="wca1_wca3_s689_wca1_wca3_sa472"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: B-cell CLL/lymphoma 9 HUGO:BCL9 HGNC:1008 ENTREZ:607 UNIPROT:O00512 GENECARDS:BCL9 KEGG:607 ATLASONC:BCL9ID466 WIKI:BCL9 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BCL9"/> <bbox w="80.0" h="40.0" x="14996.17" y="4134.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s690_wca1_wca3_sa473"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: pygopus homolog 1 (Drosophila) HUGO:PYGO1 HGNC:30256 ENTREZ:26108 UNIPROT:Q9Y3Y4 GENECARDS:PYGO1 WIKI:PYGO1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PYGO*"/> <bbox w="80.0" h="40.0" x="14996.17" y="4094.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s691_wca1_wca3_sa474"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="14996.17" y="4174.5"/> <glyph class="state variable" id="_457173d8-5678-4bf9-8167-07c56d3fe395"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="15023.574" y="4209.5"/> </glyph> <glyph class="state variable" id="_04dc5d7c-ce88-4701-9d41-fbd991431319"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="15063.052" y="4209.5"/> </glyph> <glyph class="state variable" id="_9601011c-e65c-429c-bf79-085cfa8cb321"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="15063.67" y="4169.715"/> </glyph> <glyph class="state variable" id="_00388bc8-d4bf-4dd0-87b4-30b6a5c0a6e1"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="15023.702" y="4169.5"/> </glyph> <glyph class="state variable" id="_845d967e-ceb7-4ae8-90e2-abd015403572"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="14984.162" y="4169.5"/> </glyph> <glyph class="state variable" id="_b6fc9631-60ca-4072-a978-26cf4698fd64"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="14983.67" y="4209.222"/> </glyph> <glyph class="state variable" id="_3ca5296e-622b-4ea6-8172-a7baa5e615fe"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="15061.17" y="4169.715"/> </glyph> <glyph class="state variable" id="_2d7a78db-50a4-41d2-8574-4ed2338afc0d"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="15061.17" y="4169.715"/> </glyph> <glyph class="state variable" id="_3403ddd1-f743-4c9f-915f-37634d34b70e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14991.17" y="4189.5"/> </glyph> <glyph class="state variable" id="_d66dcaa5-4682-4037-943c-619a63fc8153"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="14981.662" y="4169.5"/> </glyph> <glyph class="state variable" id="_c0c72c1a-8361-48f5-b194-7b909ca5bac3"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="15061.17" y="4169.715"/> </glyph> <glyph class="state variable" id="_06e23462-4139-4422-ac3d-0a7369187c88"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14991.17" y="4181.216"/> </glyph> <glyph class="state variable" id="_e905cdf0-d1c1-4865-9d0f-71e51736419e"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="15061.17" y="4169.715"/> </glyph> <glyph class="state variable" id="_1555c224-acc6-4cf3-acd8-6b49a2ce4a87"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14991.17" y="4189.5"/> </glyph> <glyph class="state variable" id="_1ae73080-b802-45b1-8bbf-23f7c83eaff3"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="15060.552" y="4209.5"/> </glyph> <glyph class="state variable" id="_13456002-6cb8-44c5-b292-79355caa488a"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="15061.17" y="4169.715"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s692_wca1_wca3_sa475"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end</body> </html> Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end</body> </html> </notes> <label text="CBP*"/> <bbox w="80.0" h="40.0" x="14993.83" y="4051.25"/> <glyph class="state variable" id="_f50fc30f-19fc-4ec1-825d-c00975afd795"> <state value="P" variable="S92"/> <bbox w="30.0" h="10.0" x="14979.322" y="4046.25"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s694_wca1_wca3_sa476"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> </notes> <label text="JUN"/> <bbox w="80.0" h="40.0" x="14998.0" y="4217.5"/> <glyph class="state variable" id="_a0b7b828-650b-4c4a-aabf-0746f4eaaa37"> <state value="" variable="S63"/> <bbox w="25.0" h="10.0" x="14985.992" y="4212.5"/> </glyph> <glyph class="state variable" id="_dc716e71-8257-4d82-b43c-f8a794b0c970"> <state value="" variable="S73"/> <bbox w="25.0" h="10.0" x="15025.532" y="4212.5"/> </glyph> <glyph class="state variable" id="_044ec8e1-95a6-490e-8886-f57acf98974d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14993.0" y="4232.5"/> </glyph> <glyph class="state variable" id="_ecba8eb7-43e9-4c00-b846-48b6cf9a9b2a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14990.5" y="4212.5"/> </glyph> <glyph class="state variable" id="_7fedf6d9-30d6-4368-b885-8d6782abe4cc"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14990.5" y="4252.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s693_wca1_wca3_sa477"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="14998.0" y="4262.5"/> <glyph class="state variable" id="_bb29c388-1fc4-4268-a978-b0afd7aef309"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15073.0" y="4257.5"/> </glyph> <glyph class="state variable" id="_f36c8971-28b6-47fb-8e87-1061e2523883"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14993.0" y="4257.5"/> </glyph> <glyph class="state variable" id="_5688f0d2-dd21-40f1-ad01-f9b5cb75cb02"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="15062.382" y="4297.5"/> </glyph> <glyph class="state variable" id="_0f596bc2-0778-4da2-8f24-1182efe1b5b3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14993.0" y="4257.5"/> </glyph> <glyph class="state variable" id="_c9bd3ee2-1e33-406d-866b-7a93c86ae030"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15073.0" y="4257.5"/> </glyph> <glyph class="state variable" id="_ab494643-358f-461d-8b37-1847664d17b9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15072.634" y="4257.5"/> </glyph> <glyph class="state variable" id="_1607a9f7-f50e-4b1f-8307-363a374fdcfa"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15073.0" y="4297.5"/> </glyph> <glyph class="state variable" id="_2040b6fb-7230-4d0f-9e3f-e2dee34e90c6"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="14983.0" y="4297.222"/> </glyph> <glyph class="state variable" id="_6a3f9d1c-f274-4cd2-b1e9-bb0fbd8b1de0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14993.0" y="4297.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s702_wca1_wca3_csa11" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL9:CBP*:DVL*:JUN:LEF_TCF*:PYGO*:WRE*:_beta_-Catenin* Identifiers_end References_begin: s_wca3_re12(MAP:survival): CBP-and P300-mediated transcription different cell fates PMID:20530697 s_wca3_re125(MAP:survival): CBP-mediated transcription effects genes that are involved in stemm cell or progenitor cell maintenance and proliferation PMID:20920541 Repressor complex is default present on the enhance of wnt-target genes PMID:16510874 s_wca3_re159(MAP:survival): LEF1 has been identified to be involved in transcription of the MIR371-373 cluster. Only unknown if either P300 or CTBP is involved. PMID:22020335 s_wca3_re163(MAP:survival): Though not known if this transcription is mediated by CBP in the transcripoition complex could be otherwise P300 PMID:23296977 References_end</body> </html> </notes> <label text="BCL9:CBP*:DVL*:JUN:LEF_TCF*:PYGO*:WRE*:β-Catenin*"/> <bbox w="212.0" h="250.0" x="14089.875" y="4703.125"/> <glyph class="macromolecule" id="wca1_wca3_s95_wca1_wca3_sa82"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: B-cell CLL/lymphoma 9 HUGO:BCL9 HGNC:1008 ENTREZ:607 UNIPROT:O00512 GENECARDS:BCL9 KEGG:607 ATLASONC:BCL9ID466 WIKI:BCL9 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BCL9"/> <bbox w="80.0" h="40.0" x="14107.875" y="4753.125"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s96_wca1_wca3_sa83"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: pygopus homolog 1 (Drosophila) HUGO:PYGO1 HGNC:30256 ENTREZ:26108 UNIPROT:Q9Y3Y4 GENECARDS:PYGO1 WIKI:PYGO1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PYGO*"/> <bbox w="80.0" h="40.0" x="14200.875" y="4751.125"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s129_wca1_wca3_sa84"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="14107.875" y="4793.125"/> <glyph class="state variable" id="_e05932bc-09ce-4544-8d20-800492a51ed7"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="14135.279" y="4828.125"/> </glyph> <glyph class="state variable" id="_3f32870d-9252-4bae-b5ff-bcec4e44f2ed"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="14174.757" y="4828.125"/> </glyph> <glyph class="state variable" id="_0621f67d-bb34-416c-b26b-339226c7aaef"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="14175.375" y="4788.34"/> </glyph> <glyph class="state variable" id="_e5ccba80-c834-4ec5-8bfc-70285b3e0c95"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="14135.407" y="4788.125"/> </glyph> <glyph class="state variable" id="_10f388ee-1b50-4b94-b589-a16d8d45098d"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="14095.867" y="4788.125"/> </glyph> <glyph class="state variable" id="_fa13655a-c748-4c29-b50b-9548ea17a1b5"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="14095.375" y="4827.847"/> </glyph> <glyph class="state variable" id="_fb152c5e-38f9-4422-bc92-8744e9f73f77"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="14172.875" y="4788.34"/> </glyph> <glyph class="state variable" id="_92078cde-c83b-49b7-905d-041e9d46ef9e"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="14172.875" y="4788.34"/> </glyph> <glyph class="state variable" id="_d706dfe6-6072-47ba-97a4-f1642e9db119"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14102.875" y="4808.125"/> </glyph> <glyph class="state variable" id="_913b9452-9f8b-4cc5-ae20-889b02034565"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="14093.367" y="4788.125"/> </glyph> <glyph class="state variable" id="_2f36f27b-21b0-41c5-bd87-dda5d696f094"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="14172.875" y="4788.34"/> </glyph> <glyph class="state variable" id="_b1c5239a-1fc0-4169-89df-5cd21f98913d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14102.875" y="4799.841"/> </glyph> <glyph class="state variable" id="_57729b1d-3ed5-4f06-a674-9b9494f1b57f"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="14172.875" y="4788.34"/> </glyph> <glyph class="state variable" id="_08211c58-051f-4ca3-8d2f-d10cf32dd5a4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14102.875" y="4808.125"/> </glyph> <glyph class="state variable" id="_17889a61-c271-480b-aa7f-4766efefd2e0"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="14172.257" y="4828.125"/> </glyph> <glyph class="state variable" id="_b45cb2a6-26ce-4054-9642-cbe5df9eb777"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="14172.875" y="4788.34"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s98_wca1_wca3_sa85"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>TCF family: tcf-1, lef-1, tcf-3, tcf-4 PMID:11266540 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 transcription factor 7-like 1 (T-cell specific HMG-box) TCF3 HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 transcription factor 7-like 2 (T-cell specific HMG-box) TCF4 HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end</body> </html> </notes> <label text="LEF_TCF*"/> <bbox w="80.0" h="40.0" x="14105.875" y="4846.625"/> <glyph class="state variable" id="_5ef9cc18-11b9-4bda-b79c-8f7828d8c619"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14180.875" y="4842.503"/> </glyph> <glyph class="state variable" id="_dfcde936-b034-4f90-a34b-c2f6bdfb0a2e"> <state value="" variable="S40"/> <bbox w="25.0" h="10.0" x="14173.375" y="4878.2393"/> </glyph> <glyph class="state variable" id="_493282c5-60da-49ba-a112-f6fa6801478c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14180.875" y="4861.625"/> </glyph> <glyph class="state variable" id="_1e277d1f-6c70-4d11-93be-8397d19b6577"> <state value="" variable="S166"/> <bbox w="30.0" h="10.0" x="14091.367" y="4841.625"/> </glyph> <glyph class="state variable" id="_d573a325-1cc3-42d1-a09d-b4c4df29952b"> <state value="" variable="T155"/> <bbox w="30.0" h="10.0" x="14090.875" y="4881.347"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_wca3_s99_wca1_wca3_sa86"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: WNT responsive element References_end</body> </html> </notes> <label text="WRE*"/> <bbox w="70.0" h="25.0" x="14113.125" y="4888.625"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s144_wca1_wca3_sa87"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end</body> </html> Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end</body> </html> </notes> <label text="CBP*"/> <bbox w="80.0" h="40.0" x="14199.5" y="4713.375"/> <glyph class="state variable" id="_790f2ddb-e50d-4f39-a0fa-7fc35a17144f"> <state value="P" variable="S92"/> <bbox w="30.0" h="10.0" x="14184.992" y="4708.375"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s698_wca1_wca3_sa478"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> </notes> <label text="JUN"/> <bbox w="80.0" h="40.0" x="14199.0" y="4800.5"/> <glyph class="state variable" id="_61db4103-7fd6-492b-ae92-843f8c673146"> <state value="" variable="S63"/> <bbox w="25.0" h="10.0" x="14186.992" y="4795.5"/> </glyph> <glyph class="state variable" id="_928da219-a250-4a3b-bbab-e2f67732841b"> <state value="" variable="S73"/> <bbox w="25.0" h="10.0" x="14226.532" y="4795.5"/> </glyph> <glyph class="state variable" id="_f17987c4-6f43-411a-85ec-d83328a52240"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14194.0" y="4815.5"/> </glyph> <glyph class="state variable" id="_f6bc862e-3580-4eaf-9628-3a43012a87ec"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14191.5" y="4795.5"/> </glyph> <glyph class="state variable" id="_ac5cb707-5528-41f8-b775-606c112e59ea"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14191.5" y="4835.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s697_wca1_wca3_sa479"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="14199.0" y="4843.5"/> <glyph class="state variable" id="_55bc6fcf-be81-4aea-92e8-2a2bfdc4a8a4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14274.0" y="4838.5"/> </glyph> <glyph class="state variable" id="_9ca93bdb-c91c-4c17-b710-eb4933163f92"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14194.0" y="4838.5"/> </glyph> <glyph class="state variable" id="_b3b16141-3487-43b8-816c-ed9fc4c60580"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="14263.382" y="4878.5"/> </glyph> <glyph class="state variable" id="_40bd946e-2734-443f-9a21-cddb8aa88d1b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14194.0" y="4838.5"/> </glyph> <glyph class="state variable" id="_972e3825-9a8d-4963-a869-9fd4a58615c1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14274.0" y="4838.5"/> </glyph> <glyph class="state variable" id="_3914239c-6c84-4a52-b376-179e73c8a525"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14273.634" y="4838.5"/> </glyph> <glyph class="state variable" id="_38a76b4e-1164-48ab-b65d-867a6540a974"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14274.0" y="4878.5"/> </glyph> <glyph class="state variable" id="_0720ea9f-20cd-4f72-8971-f10aacd53473"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="14184.0" y="4878.222"/> </glyph> <glyph class="state variable" id="_cbd6b5f0-b79e-4741-833b-280ab4996bfd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14194.0" y="4878.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s705_wca1_wca3_csa3" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL9:DVL*:JUN:LEF_TCF*:PYGO*:WRE*:_beta_-Catenin*:p300* Identifiers_end References_begin: s_wca3_re6(MAP:survival): PMID:16169192 B-catenin competes with TLE for Lef-1 PMID:15768032 CBP-and P300-mediated transcription different cell fates PMID:20530697 (phosphorylated) C-JUN can bind to TCF4 PMID:18347071 PMID:16007074 s_wca3_re7(MAP:survival): The transcription complex containing P300 initiates transcription of genes that are involved in differentiation. PMID:20920541 The repressor complex is is by default present on the enhancers of wnt-target genes PMID:16510874 s_wca3_re65(MAP:survival): PMID:22761862 Smad1 alone inhibits myc expression while b-catenin/TCF4 activates gene expression. Highest gene expression obtained when SMAD1/b-catenin/TCF4 complex is formed PMID:15576399 Mi-2/NuRD PMID:22290435 s_wca3_re154(MAP:survival): SOX9 PMID:23306204 p300 transcription complex PMID:15806138 WNT-target gene: PMID:20122174 s_wca3_re155(MAP:survival): Transcription complex containing b-catenin and P300 PMID:17050667 PMID:21767405 RAD6B is overexpressed in breast cancer PMID:11929833 RAD6B upregulated in invasive breast cancer PMID:22705350 s_wca3_re157(MAP:survival): BCL9 is a target gene of the wnt pathway. PMID:18627596 However not known which transcription complex is involved either with CBP or P300. I have chosen this complex randomly s_wca3_re166(MAP:survival): Not known if P300 transcription complex mediates this trancription either it is CBP transcription complex PMID:17291450 References_end</body> </html> </notes> <label text="BCL9:DVL*:JUN:LEF_TCF*:PYGO*:WRE*:β-Catenin*:p300*"/> <bbox w="121.0" h="384.0" x="13946.5" y="4308.125"/> <glyph class="macromolecule" id="wca1_wca3_s22_wca1_wca3_sa18"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: B-cell CLL/lymphoma 9 HUGO:BCL9 HGNC:1008 ENTREZ:607 UNIPROT:O00512 GENECARDS:BCL9 KEGG:607 ATLASONC:BCL9ID466 WIKI:BCL9 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BCL9"/> <bbox w="80.0" h="40.0" x="13970.0625" y="4400.125"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s23_wca1_wca3_sa19"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: pygopus homolog 1 (Drosophila) HUGO:PYGO1 HGNC:30256 ENTREZ:26108 UNIPROT:Q9Y3Y4 GENECARDS:PYGO1 WIKI:PYGO1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PYGO*"/> <bbox w="80.0" h="40.0" x="13970.0625" y="4360.125"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s120_wca1_wca3_sa20"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="13970.3125" y="4440.125"/> <glyph class="state variable" id="_e8222bd6-446d-41a1-b65d-a8cb3550db51"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="13997.717" y="4475.125"/> </glyph> <glyph class="state variable" id="_7ab05b65-0946-4c18-832b-75ce7fe69fb4"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="14037.194" y="4475.125"/> </glyph> <glyph class="state variable" id="_6ce7c796-128d-4c26-86ba-f5604ccaf478"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="14037.8125" y="4435.34"/> </glyph> <glyph class="state variable" id="_95c38596-5d35-4037-a742-093e5ceac8e1"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="13997.845" y="4435.125"/> </glyph> <glyph class="state variable" id="_5c8e08b2-2268-4e72-8052-db1e49396bf5"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="13958.305" y="4435.125"/> </glyph> <glyph class="state variable" id="_cf819bfe-47ea-4756-8b59-dc0fb69200ad"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="13957.8125" y="4474.847"/> </glyph> <glyph class="state variable" id="_a6e49b50-a017-487c-a717-78de27b7df4a"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="14035.3125" y="4435.34"/> </glyph> <glyph class="state variable" id="_92d70030-6c95-477f-824b-d91a98380585"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="14035.3125" y="4435.34"/> </glyph> <glyph class="state variable" id="_d9023d14-d45d-465e-a68e-914b42abd106"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13965.3125" y="4455.125"/> </glyph> <glyph class="state variable" id="_9d0ba1fc-cb2d-47d2-aa36-56d66d3215c3"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="13955.805" y="4435.125"/> </glyph> <glyph class="state variable" id="_68fcf2c7-b213-4e3a-be7f-231f2417a23a"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="14035.3125" y="4435.34"/> </glyph> <glyph class="state variable" id="_2493a7f3-e414-4766-904b-a35b1d37c32f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13965.3125" y="4446.841"/> </glyph> <glyph class="state variable" id="_54b57e4a-e176-4dd7-9739-68a35e566ba5"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="14035.3125" y="4435.34"/> </glyph> <glyph class="state variable" id="_32b5a7ce-e39e-43a2-b457-9cce1cb8ff55"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13965.3125" y="4455.125"/> </glyph> <glyph class="state variable" id="_366e4247-3e06-4ea4-9cb2-a59fa3eb1b2e"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="14034.694" y="4475.125"/> </glyph> <glyph class="state variable" id="_43675cd9-da95-4bce-91e5-12af348c6d53"> <state value="Ac" variable="K345"/> <bbox w="40.0" h="10.0" x="14030.3125" y="4435.34"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s19_wca1_wca3_sa21"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>TCF family: tcf-1, lef-1, tcf-3, tcf-4 PMID:11266540 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 transcription factor 7-like 1 (T-cell specific HMG-box) TCF3 HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 transcription factor 7-like 2 (T-cell specific HMG-box) TCF4 HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end</body> </html> </notes> <label text="LEF_TCF*"/> <bbox w="80.0" h="40.0" x="13969.8125" y="4485.625"/> <glyph class="state variable" id="_e711c824-5c60-446a-8827-033e6f4e8e16"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14044.8125" y="4481.503"/> </glyph> <glyph class="state variable" id="_3da7fb2c-741b-4fac-813b-2675bf5feeed"> <state value="" variable="S40"/> <bbox w="25.0" h="10.0" x="14037.3125" y="4517.2393"/> </glyph> <glyph class="state variable" id="_00413ecc-813c-47fc-ac75-e9e781f6349a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14044.8125" y="4500.625"/> </glyph> <glyph class="state variable" id="_399a9b97-24df-4398-8e25-e09cdc783b57"> <state value="" variable="S166"/> <bbox w="30.0" h="10.0" x="13955.305" y="4480.625"/> </glyph> <glyph class="state variable" id="_077f87ad-8bff-4913-9d5d-ce47621dfe5d"> <state value="" variable="T155"/> <bbox w="30.0" h="10.0" x="13954.8125" y="4520.347"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_wca3_s20_wca1_wca3_sa22"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: WNT responsive element References_end</body> </html> </notes> <label text="WRE*"/> <bbox w="70.0" h="25.0" x="13974.3125" y="4530.625"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s86_wca1_wca3_sa73"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: E1A binding protein p300 HUGO:EP300 HGNC:3373 ENTREZ:2033 UNIPROT:Q09472 GENECARDS:EP300 REACTOME:61164 KEGG:2033 ATLASONC:P300ID97 WIKI:EP300 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:HIF1 MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="p300*"/> <bbox w="80.0" h="40.0" x="13969.875" y="4322.375"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s704_wca1_wca3_sa480"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> </notes> <label text="JUN"/> <bbox w="80.0" h="40.0" x="13968.0" y="4560.5"/> <glyph class="state variable" id="_4ac465c3-c8e7-4c80-9249-40d6c51735b1"> <state value="" variable="S63"/> <bbox w="25.0" h="10.0" x="13955.992" y="4555.5"/> </glyph> <glyph class="state variable" id="_36b73826-23ba-421a-9db7-5335cd4597e7"> <state value="" variable="S73"/> <bbox w="25.0" h="10.0" x="13995.532" y="4555.5"/> </glyph> <glyph class="state variable" id="_37225e49-eccc-4183-9e84-7141012a88ef"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13963.0" y="4575.5"/> </glyph> <glyph class="state variable" id="_5ac9e19a-d33b-46ab-be08-0ebefc7922de"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="13960.5" y="4555.5"/> </glyph> <glyph class="state variable" id="_ddf0c842-a297-41b1-81f3-edf6cc76bdce"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="13960.5" y="4595.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s703_wca1_wca3_sa481"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="13968.0" y="4605.5"/> <glyph class="state variable" id="_051c07f7-75c7-4982-a864-f0e9f674578a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14043.0" y="4600.5"/> </glyph> <glyph class="state variable" id="_f08b17b9-c300-47ef-a570-7e9f58656d15"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13963.0" y="4600.5"/> </glyph> <glyph class="state variable" id="_19074aa3-a3d9-470c-9dc7-85bb09eb529f"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="14032.382" y="4640.5"/> </glyph> <glyph class="state variable" id="_390bb321-3f37-4830-8576-895dc40c2835"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13963.0" y="4600.5"/> </glyph> <glyph class="state variable" id="_a0991b85-8c11-4c0b-9ed8-77caa49a54ae"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14043.0" y="4600.5"/> </glyph> <glyph class="state variable" id="_bf13e738-5b52-458b-a6ad-daa8b26c8dfb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14042.634" y="4600.5"/> </glyph> <glyph class="state variable" id="_06ef9be1-5074-4221-8466-13131179eede"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14043.0" y="4640.5"/> </glyph> <glyph class="state variable" id="_e66f6409-7ff0-4947-a1d5-e5f9fcadf657"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="13953.0" y="4640.222"/> </glyph> <glyph class="state variable" id="_a40f7154-4c4a-4cb9-b9dc-0eea23a3629c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13963.0" y="4640.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s708_wca1_wca3_csa49" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC:BCL9:CTBP*:DVL*:HDAC1_2*:JUN:LEF_TCF*:PYGO*:WRE*:_beta_-Catenin*:p300* Identifiers_end References_begin: s_wca3_re109:(MAP:survival) PMID:12711682 PMID:15834423 PMID:16510874 PMID:15327769 PMID:16547505 References_end</body> </html> </notes> <label text="APC:BCL9:CTBP*:DVL*:HDAC1_2*:JUN:LEF_TCF*:PYGO*:WRE*:β-Catenin*:p300*"/> <bbox w="122.0" h="526.0" x="13633.25" y="4661.5"/> <glyph class="macromolecule" id="wca1_wca3_s390_wca1_wca3_sa305"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: B-cell CLL/lymphoma 9 HUGO:BCL9 HGNC:1008 ENTREZ:607 UNIPROT:O00512 GENECARDS:BCL9 KEGG:607 ATLASONC:BCL9ID466 WIKI:BCL9 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BCL9"/> <bbox w="80.0" h="40.0" x="13648.8125" y="4881.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s391_wca1_wca3_sa306"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: pygopus homolog 1 (Drosophila) HUGO:PYGO1 HGNC:30256 ENTREZ:26108 UNIPROT:Q9Y3Y4 GENECARDS:PYGO1 WIKI:PYGO1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PYGO*"/> <bbox w="80.0" h="40.0" x="13648.8125" y="4841.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s392_wca1_wca3_sa307"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="13649.0625" y="4921.5"/> <glyph class="state variable" id="_f4900eeb-72c3-45b1-a5d2-c9656a9fde32"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="13676.467" y="4956.5"/> </glyph> <glyph class="state variable" id="_54ba8f8a-233a-4d7d-8dab-a4e6cef13f61"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="13715.944" y="4956.5"/> </glyph> <glyph class="state variable" id="_156e39fa-2ac5-4453-b713-1d8bbf2cd508"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="13716.5625" y="4916.715"/> </glyph> <glyph class="state variable" id="_82b251fb-d366-4d19-a6a5-4e3dfbcf9ca1"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="13676.595" y="4916.5"/> </glyph> <glyph class="state variable" id="_7879c0e0-8a70-4280-8433-4ea3a7103c86"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="13637.055" y="4916.5"/> </glyph> <glyph class="state variable" id="_6bac0752-e260-4bf1-98b0-bfa446e18d56"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="13636.5625" y="4956.222"/> </glyph> <glyph class="state variable" id="_5cd0f29f-d009-44fc-8cb8-0520c9d79a26"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="13714.0625" y="4916.715"/> </glyph> <glyph class="state variable" id="_5d49689d-941b-4f96-9de6-627ee2d8af47"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="13714.0625" y="4916.715"/> </glyph> <glyph class="state variable" id="_11edc34a-1712-47dd-a14d-87f2b37d9bc7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13644.0625" y="4936.5"/> </glyph> <glyph class="state variable" id="_6b717c67-fd7d-45fc-ab10-b7f2e746fe96"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="13634.555" y="4916.5"/> </glyph> <glyph class="state variable" id="_827620e0-963d-4b04-b0ca-5ef7017320ca"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="13714.0625" y="4916.715"/> </glyph> <glyph class="state variable" id="_6c838c57-65be-4770-97c8-f5c2a6cf26aa"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13644.0625" y="4928.216"/> </glyph> <glyph class="state variable" id="_a7541c0d-fd20-4155-a923-72747f6b95bb"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="13714.0625" y="4916.715"/> </glyph> <glyph class="state variable" id="_5c68af78-abf8-46c5-876d-ecd40037b2d7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13644.0625" y="4936.5"/> </glyph> <glyph class="state variable" id="_0e809d57-c3e1-45c8-8ea0-542487dfd908"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="13713.444" y="4956.5"/> </glyph> <glyph class="state variable" id="_c2ff2c50-08d8-4c6d-9a53-e630e11de520"> <state value="Ac" variable="K345"/> <bbox w="40.0" h="10.0" x="13709.0625" y="4916.715"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s393_wca1_wca3_sa308"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>TCF family: tcf-1, lef-1, tcf-3, tcf-4 PMID:11266540 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 transcription factor 7-like 1 (T-cell specific HMG-box) TCF3 HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 transcription factor 7-like 2 (T-cell specific HMG-box) TCF4 HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end</body> </html> </notes> <label text="LEF_TCF*"/> <bbox w="80.0" h="40.0" x="13649.5625" y="4969.0"/> <glyph class="state variable" id="_5e63ff6f-0e8b-4e42-a317-729abb613c21"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13724.5625" y="4964.878"/> </glyph> <glyph class="state variable" id="_981dd6c2-fd72-4d20-9a0a-b2f064d11f26"> <state value="" variable="S40"/> <bbox w="25.0" h="10.0" x="13717.0625" y="5000.6143"/> </glyph> <glyph class="state variable" id="_c6d17285-3322-4f00-a618-3beef4ed23c3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13724.5625" y="4984.0"/> </glyph> <glyph class="state variable" id="_a7970e96-e734-4c45-8edb-fe333e5872e6"> <state value="" variable="S166"/> <bbox w="30.0" h="10.0" x="13635.055" y="4964.0"/> </glyph> <glyph class="state variable" id="_f7d84150-ec27-49dd-8ac5-f8f698609077"> <state value="" variable="T155"/> <bbox w="30.0" h="10.0" x="13634.5625" y="5003.722"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_wca3_s394_wca1_wca3_sa309"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: WNT responsive element References_end</body> </html> </notes> <label text="WRE*"/> <bbox w="70.0" h="25.0" x="13654.0625" y="5014.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s395_wca1_wca3_sa310"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: E1A binding protein p300 HUGO:EP300 HGNC:3373 ENTREZ:2033 UNIPROT:Q09472 GENECARDS:EP300 REACTOME:61164 KEGG:2033 ATLASONC:P300ID97 WIKI:EP300 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:HIF1 MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="p300*"/> <bbox w="80.0" h="40.0" x="13648.625" y="4803.75"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s388_wca1_wca3_sa311"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="13643.5" y="4671.5"/> <glyph class="state variable" id="_4b28ae41-234f-4084-a295-15cfd4ec923f"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="13705.382" y="4706.5"/> </glyph> <glyph class="state variable" id="_cebd130e-20a6-460c-bf33-6518633b7efc"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="13626.492" y="4666.5"/> </glyph> <glyph class="state variable" id="_32437671-540c-4455-aa38-4bc9d5faaadf"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="13706.0" y="4666.715"/> </glyph> <glyph class="state variable" id="_dac5118d-dc16-4c3a-822f-4337ece81695"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="13665.904" y="4706.5"/> </glyph> <glyph class="state variable" id="_3d3844b5-ec6a-4559-b78c-091c2b615fc8"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="13666.032" y="4666.5"/> </glyph> <glyph class="state variable" id="_d9e2e08d-bbf2-4856-88d9-69b76d812be7"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="13626.0" y="4706.222"/> </glyph> <glyph class="state variable" id="_5c430d00-a262-4e12-a2b6-99a9900b9d55"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13718.5" y="4666.5"/> </glyph> <glyph class="state variable" id="_d5210b5d-f935-4619-84b1-21a7ec12f891"> <state value="P" variable="T1487"/> <bbox w="40.0" h="10.0" x="13703.5" y="4705.631"/> </glyph> <glyph class="state variable" id="_8a874c5f-9f3b-4919-8f32-c73767b7138e"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="13626.0" y="4706.222"/> </glyph> <glyph class="state variable" id="_2d26d537-e256-4a22-a0ae-7379e6f30d15"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13631.492" y="4666.5"/> </glyph> <glyph class="state variable" id="_9a406fce-5aa8-4062-b3e6-bd1d46eb6ef5"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="13626.492" y="4666.5"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="wca1_wca3_s397_wca1_wca3_sa312"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: C-terminal binding protein 1 HUGO:CTBP1 HGNC:2494 ENTREZ:1487 UNIPROT:Q13363 GENECARDS:CTBP1 KEGG:1487 ATLASONC:GC_CTBP1 WIKI:CTBP1 C-terminal binding protein 2 HUGO:CTBP2 HGNC:2495 ENTREZ:1488 UNIPROT:P56545 GENECARDS:CTBP2 ATLASONC:GC_CTBP2 WIKI:CTBP2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTBP*"/> <bbox w="86.0" h="46.0" x="13648.5" y="4718.0"/> <glyph class="unit of information" id="_9c90cc16-fd7b-45a5-a30a-aecadc1bdf0d"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="13681.5" y="4713.0"/> </glyph> <glyph class="state variable" id="_8b2ad87d-5fa0-44ad-baa0-7da164eb313a"> <state value="" variable="S422"/> <bbox w="30.0" h="10.0" x="13719.5" y="4713.247"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s396_wca1_wca3_sa313"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: histone deacetylase 1 HUGO:HDAC1 HGNC:4852 ENTREZ:3065 UNIPROT:Q13547 GENECARDS:HDAC1 REACTOME:56408 KEGG:3065 ATLASONC:GC_HDAC1 WIKI:HDAC1 HUGO:HDAC2 HGNC:4853 ENTREZ:3066 UNIPROT:Q92769 GENECARDS:HDAC2 REACTOME:56410 KEGG:3066 ATLASONC:HDAC2ID40803ch6q22 WIKI:HDAC2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HDAC1_2*"/> <bbox w="80.0" h="40.0" x="13648.5" y="4763.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s707_wca1_wca3_sa482"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> </notes> <label text="JUN"/> <bbox w="80.0" h="40.0" x="13651.0" y="5045.5"/> <glyph class="state variable" id="_187c9322-23d1-4999-9341-8ea8e6cf7279"> <state value="" variable="S63"/> <bbox w="25.0" h="10.0" x="13638.992" y="5040.5"/> </glyph> <glyph class="state variable" id="_cfc703c0-28ab-4bd1-b77c-743b785ca5ce"> <state value="" variable="S73"/> <bbox w="25.0" h="10.0" x="13678.532" y="5040.5"/> </glyph> <glyph class="state variable" id="_6406efb5-3eb3-45fb-921d-c18f113ac048"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13646.0" y="5060.5"/> </glyph> <glyph class="state variable" id="_0b61bf84-3893-443e-9108-6cda25f386fd"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="13643.5" y="5040.5"/> </glyph> <glyph class="state variable" id="_b7698c7f-0e47-4314-8c9a-7662082147da"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="13643.5" y="5080.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s706_wca1_wca3_sa483"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="13651.0" y="5090.5"/> <glyph class="state variable" id="_c64cff6d-3016-4e1b-b31c-6d819613fc27"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13726.0" y="5085.5"/> </glyph> <glyph class="state variable" id="_c96a874e-0e6a-41c4-be6d-25d3e7641dad"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13646.0" y="5085.5"/> </glyph> <glyph class="state variable" id="_62b927d7-72c4-42c0-a943-97f5ba86b1ba"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="13715.382" y="5125.5"/> </glyph> <glyph class="state variable" id="_82f2b71e-8e0a-4b41-9ace-1435220f087e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13646.0" y="5085.5"/> </glyph> <glyph class="state variable" id="_149d4b83-3337-49b4-8e20-4ca26c51214f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13726.0" y="5085.5"/> </glyph> <glyph class="state variable" id="_d6505dca-93b1-4a01-8650-449b9afd37e6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13725.634" y="5085.5"/> </glyph> <glyph class="state variable" id="_38569fe9-5d69-4d87-b4fb-c806f8661733"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13726.0" y="5125.5"/> </glyph> <glyph class="state variable" id="_bc62559c-5961-45da-9dca-1f9ce67255bb"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="13636.0" y="5125.222"/> </glyph> <glyph class="state variable" id="_c01ecdde-893b-4689-b335-24e598fb9ebc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13646.0" y="5125.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s788_wca1_wca3_csa33" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC:CK2_alpha_:CK2_alpha_*:CK2_beta_* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: The c-terminus of APC inhibits activity of CK2 PMID:11972058 s_wca3_re76(MAP:survival): Complex formation of APC and CK2 is cell-cycle dependent References_end</body> </html> </notes> <label text="(CK2/APC)"/> <bbox w="95.0" h="157.0" x="12877.0" y="3377.5"/> <glyph class="macromolecule" id="wca1_wca3_s296_wca1_wca3_sa227"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="12882.0" y="3396.0"/> <glyph class="state variable" id="_a3e453ef-962e-4c31-b257-52d5b3195a89"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="12943.882" y="3431.0"/> </glyph> <glyph class="state variable" id="_36b7f24c-aa84-47b8-8846-e7943af7f1bb"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="12864.992" y="3391.0"/> </glyph> <glyph class="state variable" id="_7a0b92cd-5085-4593-a049-22540b3a6a22"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="12944.5" y="3391.2148"/> </glyph> <glyph class="state variable" id="_d16298b2-1f8a-47b6-9b8e-c5c8ead1cd98"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="12904.404" y="3431.0"/> </glyph> <glyph class="state variable" id="_cc52325c-e838-46a3-b709-0a4e85de857f"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="12904.532" y="3391.0"/> </glyph> <glyph class="state variable" id="_cc2a5332-bd34-4f9c-91e6-aa98f28e1cb9"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="12864.5" y="3430.7224"/> </glyph> <glyph class="state variable" id="_075098d2-c44e-414e-94cd-077c9e90b58e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12957.0" y="3391.0"/> </glyph> <glyph class="state variable" id="_e9364c5c-1d61-41f1-b6b5-2f568a71b23b"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="12944.5" y="3430.1306"/> </glyph> <glyph class="state variable" id="_f460888e-410d-4555-b815-3a36452de52f"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="12864.5" y="3430.7224"/> </glyph> <glyph class="state variable" id="_7becaa4f-d1aa-41eb-9936-f289dc7f475c"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12869.992" y="3391.0"/> </glyph> <glyph class="state variable" id="_d5042fb1-bc2b-405d-b125-c840a10e6d10"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="12864.992" y="3391.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s297_wca1_wca3_sa228"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 alpha 1 polypeptide HUGO:CSNK2A1 HGNC:2457 ENTREZ:1457 UNIPROT:P68400 GENECARDS:CSNK2A1 REACTOME:201673 KEGG:1457 ATLASONC:GC_CSNK2A1 WIKI:CSNK2A1 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 alpha 1 polypeptide HUGO:CSNK2A1 HGNC:2457 ENTREZ:1457 UNIPROT:P68400 GENECARDS:CSNK2A1 REACTOME:201673 KEGG:1457 ATLASONC:GC_CSNK2A1 WIKI:CSNK2A1 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2α*"/> <bbox w="30.0" h="30.0" x="12884.0" y="3442.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s298_wca1_wca3_sa229"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 alpha prime polypeptide HUGO:CSNK2A2 HGNC:2459 ENTREZ:1459 UNIPROT:P19784 GENECARDS:CSNK2A2 REACTOME:57879 KEGG:1459 ATLASONC:GC_CSNK2A2 WIKI:CSNK2A2 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 alpha prime polypeptide HUGO:CSNK2A2 HGNC:2459 ENTREZ:1459 UNIPROT:P19784 GENECARDS:CSNK2A2 REACTOME:57879 KEGG:1459 ATLASONC:GC_CSNK2A2 WIKI:CSNK2A2 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2α'*"/> <bbox w="30.0" h="30.0" x="12917.0" y="3442.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s789_wca1_wca3_sa230"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2β*"/> <bbox w="30.0" h="30.0" x="12884.0" y="3477.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s789_wca1_wca3_sa231"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2β*"/> <bbox w="30.0" h="30.0" x="12917.0" y="3477.5"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s794_wca1_wca3_csa73" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PKA_C*:PKA_R* Identifiers_end References_begin: s_wca3_re82(MAP:survival): High-cell density has positive influence on phosphorylation of APC by PKA thereby blocking nuclear import. PMID:11689703 s_wca3_re101(MAP:survival): References_begin PMID:15649893 References_end</body> </html> </notes> <label text="(PKA)"/> <bbox w="113.0" h="109.0" x="12889.0" y="3907.0"/> <glyph class="macromolecule" id="wca1_wca3_s795_wca1_wca3_sa484"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: protein kinase AMP-activated beta 1 non-catalytic subunit HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478 GENECARDS:PRKAB1 REACTOME:49384 KEGG:5564 ATLASONC:PRKAB1ID44100ch12q24 WIKI:PRKAB1 protein kinase AMP-activated beta 2 non-catalytic subunit HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741 GENECARDS:PRKAB2 REACTOME:49386 ATLASONC:GC_PRKAB2 WIKI:PRKAB2 protein kinase AMP-activated gamma 1 non-catalytic subunit HUGO:PRKAG1 HGNC:9385 ENTREZ:5571 UNIPROT:P54619 GENECARDS:PRKAG1 REACTOME:49388 KEGG:5571 ATLASONC:GC_PRKAG1 WIKI:PRKAG1 protein kinase AMP-activated gamma 2 non-catalytic subunit HUGO:PRKAG2 HGNC:9386 ENTREZ:51422 UNIPROT:Q9UGJ0 GENECARDS:PRKAG2 REACTOME:49390 KEGG:51422 ATLASONC:GC_PRKAG2 WIKI:PRKAG2 HUGO:PRKAG3 HGNC:9387 ENTREZ:53632 UNIPROT:Q9UGI9 GENECARDS:PRKAG3 REACTOME:49392 KEGG:53632 ATLASONC:GC_PRKAG3 WIKI:PRKAG3 protein kinase cAMP-dependent regulatory type I alpha HUGO:PRKAR1A HGNC:9388 ENTREZ:5573 UNIPROT:P10644 GENECARDS:PRKAR1A REACTOME:57837 KEGG:5573 ATLASONC:PRKAR1AID387 WIKI:PRKAR1A protein kinase cAMP-dependent regulatory type I beta HUGO:PRKAR1B HGNC:9390 ENTREZ:5575 UNIPROT:P31321 GENECARDS:PRKAR1B REACTOME:57839 KEGG:5575 ATLASONC:GC_PRKAR1B WIKI:PRKAR1B protein kinase cAMP-dependent regulatory type II alpha HUGO:PRKAR2A HGNC:9391 ENTREZ:5576 UNIPROT:P13861 GENECARDS:PRKAR2A REACTOME:57841 KEGG:5576 ATLASONC:GC_PRKAR2A WIKI:PRKAR2A protein kinase cAMP-dependent regulatory type II beta HUGO:PRKAR2B HGNC:9392 ENTREZ:5577 UNIPROT:P31323 GENECARDS:PRKAR2B REACTOME:57843 KEGG:5577 ATLASONC:GC_PRKAR2B WIKI:PRKAR2B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: protein kinase AMP-activated beta 1 non-catalytic subunit HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478 GENECARDS:PRKAB1 REACTOME:49384 KEGG:5564 ATLASONC:PRKAB1ID44100ch12q24 WIKI:PRKAB1 protein kinase AMP-activated beta 2 non-catalytic subunit HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741 GENECARDS:PRKAB2 REACTOME:49386 ATLASONC:GC_PRKAB2 WIKI:PRKAB2 protein kinase AMP-activated gamma 1 non-catalytic subunit HUGO:PRKAG1 HGNC:9385 ENTREZ:5571 UNIPROT:P54619 GENECARDS:PRKAG1 REACTOME:49388 KEGG:5571 ATLASONC:GC_PRKAG1 WIKI:PRKAG1 protein kinase AMP-activated gamma 2 non-catalytic subunit HUGO:PRKAG2 HGNC:9386 ENTREZ:51422 UNIPROT:Q9UGJ0 GENECARDS:PRKAG2 REACTOME:49390 KEGG:51422 ATLASONC:GC_PRKAG2 WIKI:PRKAG2 HUGO:PRKAG3 HGNC:9387 ENTREZ:53632 UNIPROT:Q9UGI9 GENECARDS:PRKAG3 REACTOME:49392 KEGG:53632 ATLASONC:GC_PRKAG3 WIKI:PRKAG3 protein kinase cAMP-dependent regulatory type I alpha HUGO:PRKAR1A HGNC:9388 ENTREZ:5573 UNIPROT:P10644 GENECARDS:PRKAR1A REACTOME:57837 KEGG:5573 ATLASONC:PRKAR1AID387 WIKI:PRKAR1A protein kinase cAMP-dependent regulatory type I beta HUGO:PRKAR1B HGNC:9390 ENTREZ:5575 UNIPROT:P31321 GENECARDS:PRKAR1B REACTOME:57839 KEGG:5575 ATLASONC:GC_PRKAR1B WIKI:PRKAR1B protein kinase cAMP-dependent regulatory type II alpha HUGO:PRKAR2A HGNC:9391 ENTREZ:5576 UNIPROT:P13861 GENECARDS:PRKAR2A REACTOME:57841 KEGG:5576 ATLASONC:GC_PRKAR2A WIKI:PRKAR2A protein kinase cAMP-dependent regulatory type II beta HUGO:PRKAR2B HGNC:9392 ENTREZ:5577 UNIPROT:P31323 GENECARDS:PRKAR2B REACTOME:57843 KEGG:5577 ATLASONC:GC_PRKAR2B WIKI:PRKAR2B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PKA_R*"/> <bbox w="45.0" h="35.0" x="12896.0" y="3916.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s796_wca1_wca3_sa485"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: HUGO:PRKAA1 HGNC:9376 ENTREZ:5562 UNIPROT:Q13131 GENECARDS:PRKAA1 REACTOME:49380 KEGG:5562 ATLASONC:GC_PRKAA1 WIKI:PRKAA1 HUGO:PRKAA2 HGNC:9377 ENTREZ:5563 UNIPROT:P54646 GENECARDS:PRKAA2 REACTOME:49382 KEGG:5563 ATLASONC:GC_PRKAA2 WIKI:PRKAA2 HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 GENECARDS:PRKACG REACTOME:57849 KEGG:5568 ATLASONC:GC_PRKACG WIKI:PRKACG Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: HUGO:PRKAA1 HGNC:9376 ENTREZ:5562 UNIPROT:Q13131 GENECARDS:PRKAA1 REACTOME:49380 KEGG:5562 ATLASONC:GC_PRKAA1 WIKI:PRKAA1 HUGO:PRKAA2 HGNC:9377 ENTREZ:5563 UNIPROT:P54646 GENECARDS:PRKAA2 REACTOME:49382 KEGG:5563 ATLASONC:GC_PRKAA2 WIKI:PRKAA2 HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 GENECARDS:PRKACG REACTOME:57849 KEGG:5568 ATLASONC:GC_PRKACG WIKI:PRKACG Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PKA_C*"/> <bbox w="45.0" h="35.0" x="12896.0" y="3957.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s795_wca1_wca3_sa486"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: protein kinase AMP-activated beta 1 non-catalytic subunit HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478 GENECARDS:PRKAB1 REACTOME:49384 KEGG:5564 ATLASONC:PRKAB1ID44100ch12q24 WIKI:PRKAB1 protein kinase AMP-activated beta 2 non-catalytic subunit HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741 GENECARDS:PRKAB2 REACTOME:49386 ATLASONC:GC_PRKAB2 WIKI:PRKAB2 protein kinase AMP-activated gamma 1 non-catalytic subunit HUGO:PRKAG1 HGNC:9385 ENTREZ:5571 UNIPROT:P54619 GENECARDS:PRKAG1 REACTOME:49388 KEGG:5571 ATLASONC:GC_PRKAG1 WIKI:PRKAG1 protein kinase AMP-activated gamma 2 non-catalytic subunit HUGO:PRKAG2 HGNC:9386 ENTREZ:51422 UNIPROT:Q9UGJ0 GENECARDS:PRKAG2 REACTOME:49390 KEGG:51422 ATLASONC:GC_PRKAG2 WIKI:PRKAG2 HUGO:PRKAG3 HGNC:9387 ENTREZ:53632 UNIPROT:Q9UGI9 GENECARDS:PRKAG3 REACTOME:49392 KEGG:53632 ATLASONC:GC_PRKAG3 WIKI:PRKAG3 protein kinase cAMP-dependent regulatory type I alpha HUGO:PRKAR1A HGNC:9388 ENTREZ:5573 UNIPROT:P10644 GENECARDS:PRKAR1A REACTOME:57837 KEGG:5573 ATLASONC:PRKAR1AID387 WIKI:PRKAR1A protein kinase cAMP-dependent regulatory type I beta HUGO:PRKAR1B HGNC:9390 ENTREZ:5575 UNIPROT:P31321 GENECARDS:PRKAR1B REACTOME:57839 KEGG:5575 ATLASONC:GC_PRKAR1B WIKI:PRKAR1B protein kinase cAMP-dependent regulatory type II alpha HUGO:PRKAR2A HGNC:9391 ENTREZ:5576 UNIPROT:P13861 GENECARDS:PRKAR2A REACTOME:57841 KEGG:5576 ATLASONC:GC_PRKAR2A WIKI:PRKAR2A protein kinase cAMP-dependent regulatory type II beta HUGO:PRKAR2B HGNC:9392 ENTREZ:5577 UNIPROT:P31323 GENECARDS:PRKAR2B REACTOME:57843 KEGG:5577 ATLASONC:GC_PRKAR2B WIKI:PRKAR2B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: protein kinase AMP-activated beta 1 non-catalytic subunit HUGO:PRKAB1 HGNC:9378 ENTREZ:5564 UNIPROT:Q9Y478 GENECARDS:PRKAB1 REACTOME:49384 KEGG:5564 ATLASONC:PRKAB1ID44100ch12q24 WIKI:PRKAB1 protein kinase AMP-activated beta 2 non-catalytic subunit HUGO:PRKAB2 HGNC:9379 ENTREZ:5565 UNIPROT:O43741 GENECARDS:PRKAB2 REACTOME:49386 ATLASONC:GC_PRKAB2 WIKI:PRKAB2 protein kinase AMP-activated gamma 1 non-catalytic subunit HUGO:PRKAG1 HGNC:9385 ENTREZ:5571 UNIPROT:P54619 GENECARDS:PRKAG1 REACTOME:49388 KEGG:5571 ATLASONC:GC_PRKAG1 WIKI:PRKAG1 protein kinase AMP-activated gamma 2 non-catalytic subunit HUGO:PRKAG2 HGNC:9386 ENTREZ:51422 UNIPROT:Q9UGJ0 GENECARDS:PRKAG2 REACTOME:49390 KEGG:51422 ATLASONC:GC_PRKAG2 WIKI:PRKAG2 HUGO:PRKAG3 HGNC:9387 ENTREZ:53632 UNIPROT:Q9UGI9 GENECARDS:PRKAG3 REACTOME:49392 KEGG:53632 ATLASONC:GC_PRKAG3 WIKI:PRKAG3 protein kinase cAMP-dependent regulatory type I alpha HUGO:PRKAR1A HGNC:9388 ENTREZ:5573 UNIPROT:P10644 GENECARDS:PRKAR1A REACTOME:57837 KEGG:5573 ATLASONC:PRKAR1AID387 WIKI:PRKAR1A protein kinase cAMP-dependent regulatory type I beta HUGO:PRKAR1B HGNC:9390 ENTREZ:5575 UNIPROT:P31321 GENECARDS:PRKAR1B REACTOME:57839 KEGG:5575 ATLASONC:GC_PRKAR1B WIKI:PRKAR1B protein kinase cAMP-dependent regulatory type II alpha HUGO:PRKAR2A HGNC:9391 ENTREZ:5576 UNIPROT:P13861 GENECARDS:PRKAR2A REACTOME:57841 KEGG:5576 ATLASONC:GC_PRKAR2A WIKI:PRKAR2A protein kinase cAMP-dependent regulatory type II beta HUGO:PRKAR2B HGNC:9392 ENTREZ:5577 UNIPROT:P31323 GENECARDS:PRKAR2B REACTOME:57843 KEGG:5577 ATLASONC:GC_PRKAR2B WIKI:PRKAR2B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PKA_R*"/> <bbox w="45.0" h="35.0" x="12946.0" y="3916.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s796_wca1_wca3_sa487"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: HUGO:PRKAA1 HGNC:9376 ENTREZ:5562 UNIPROT:Q13131 GENECARDS:PRKAA1 REACTOME:49380 KEGG:5562 ATLASONC:GC_PRKAA1 WIKI:PRKAA1 HUGO:PRKAA2 HGNC:9377 ENTREZ:5563 UNIPROT:P54646 GENECARDS:PRKAA2 REACTOME:49382 KEGG:5563 ATLASONC:GC_PRKAA2 WIKI:PRKAA2 HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 GENECARDS:PRKACG REACTOME:57849 KEGG:5568 ATLASONC:GC_PRKACG WIKI:PRKACG Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: HUGO:PRKAA1 HGNC:9376 ENTREZ:5562 UNIPROT:Q13131 GENECARDS:PRKAA1 REACTOME:49380 KEGG:5562 ATLASONC:GC_PRKAA1 WIKI:PRKAA1 HUGO:PRKAA2 HGNC:9377 ENTREZ:5563 UNIPROT:P54646 GENECARDS:PRKAA2 REACTOME:49382 KEGG:5563 ATLASONC:GC_PRKAA2 WIKI:PRKAA2 HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB HUGO:PRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 GENECARDS:PRKACG REACTOME:57849 KEGG:5568 ATLASONC:GC_PRKACG WIKI:PRKACG Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PKA_C*"/> <bbox w="45.0" h="35.0" x="12946.0" y="3957.5"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s798_wca1_wca3_csa36" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC:_beta_-Catenin* Identifiers_end References_begin: s_wca3_re86:(MAP:survival) PMID:10980707 PMID:12606575 References_end</body> </html> </notes> <label text="APC:β-Catenin*"/> <bbox w="100.0" h="120.0" x="12892.0" y="4034.0"/> <glyph class="macromolecule" id="wca1_wca3_s321_wca1_wca3_sa246"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="12903.75" y="4041.0"/> <glyph class="state variable" id="_c3dd7d70-f584-4445-b2be-0e7c7a6991bb"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="12965.632" y="4076.0"/> </glyph> <glyph class="state variable" id="_743ce3a1-b472-4242-bb24-d745933042d2"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="12886.742" y="4036.0"/> </glyph> <glyph class="state variable" id="_ea304e95-9ccf-4ac7-a0ea-64f6117b5130"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="12966.25" y="4036.2148"/> </glyph> <glyph class="state variable" id="_e5479547-218d-4cbe-abda-24cb806af2d1"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="12926.154" y="4076.0"/> </glyph> <glyph class="state variable" id="_8e12e0d7-9864-4f1f-8a19-e17035220e37"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="12926.282" y="4036.0"/> </glyph> <glyph class="state variable" id="_6a6205d6-5379-4073-8e3e-ceb10a916e39"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="12886.25" y="4075.7224"/> </glyph> <glyph class="state variable" id="_7fc48b8e-504a-48e9-8d6d-5854111309c2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12978.75" y="4036.0"/> </glyph> <glyph class="state variable" id="_995d68d4-60f1-4752-a4a4-3887b146802a"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="12966.25" y="4075.1306"/> </glyph> <glyph class="state variable" id="_a31d16f4-263c-46a3-a953-c64e16ec458f"> <state value="P" variable="S2034"/> <bbox w="40.0" h="10.0" x="12883.75" y="4075.7224"/> </glyph> <glyph class="state variable" id="_0f5f0dec-82d8-46c8-811c-c5f0d73fbb18"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12891.742" y="4036.0"/> </glyph> <glyph class="state variable" id="_ebf3137e-2d85-45f0-9fe6-918ba295c47b"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="12886.742" y="4036.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s322_wca1_wca3_sa247"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="12903.75" y="4086.0"/> <glyph class="state variable" id="_b6170319-22ea-4889-96e7-a4aae9553e50"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="12931.154" y="4121.0"/> </glyph> <glyph class="state variable" id="_fa2e50bc-4a00-4b08-8b08-9fe000edd952"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="12970.632" y="4121.0"/> </glyph> <glyph class="state variable" id="_ab9a00d6-f72c-4bea-abd0-acf5fa1e23f2"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="12971.25" y="4081.2148"/> </glyph> <glyph class="state variable" id="_5a3c3cb2-d8a8-4216-99be-ea14af89a52e"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="12931.282" y="4081.0"/> </glyph> <glyph class="state variable" id="_c485f654-1eee-473f-b067-acf4c148fe4a"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="12891.742" y="4081.0"/> </glyph> <glyph class="state variable" id="_d399907e-c1d5-4680-ba22-2848a4b72b72"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="12891.25" y="4120.722"/> </glyph> <glyph class="state variable" id="_48dfbe9c-7056-482e-ad81-080495af79b9"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="12968.75" y="4081.2148"/> </glyph> <glyph class="state variable" id="_9d66844e-87a5-4fe1-aa81-de92b1879b90"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="12968.75" y="4081.2148"/> </glyph> <glyph class="state variable" id="_9b8c3958-9274-45f2-aeff-fd1271503878"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12898.75" y="4101.0"/> </glyph> <glyph class="state variable" id="_74a8db5a-a64a-4683-9c05-83b8e3d65116"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="12889.242" y="4081.0"/> </glyph> <glyph class="state variable" id="_aa76d22d-2e8e-4880-aed9-6f68bea0880e"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="12968.75" y="4081.2148"/> </glyph> <glyph class="state variable" id="_03d33773-999b-4011-9eef-3bb5334c4e5c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12898.75" y="4092.7158"/> </glyph> <glyph class="state variable" id="_ec9bea03-415f-43a1-8c97-cd00a46abe6d"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="12968.75" y="4081.2148"/> </glyph> <glyph class="state variable" id="_c1eb38f4-d924-448f-918c-1ed51f1bcdb0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12898.75" y="4101.0"/> </glyph> <glyph class="state variable" id="_6579756b-78da-4d0e-bf78-fc8dd9e63178"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="12968.132" y="4121.0"/> </glyph> <glyph class="state variable" id="_9bdc9f0d-647a-4a22-8ca6-ddd3b52b245a"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="12968.75" y="4081.2148"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s799_wca1_wca3_csa60" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CHD3_4*:GATAD2A_B*:HDAC1_2*:MBD2_3*:MTA1_2_3*:RBBP4_7* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: ATP-dependent chromatin-remodeling complex PMID:19923891 PMID:22290435 PMID:21734722 s_wca3_re44(MAP:survival): Mi-2/NuRD PMID:22290435 SWI/SNF s_wca3_re65(MAP:survival): PMID:22761862 Smad1 alone inhibits myc expression while b-catenin/TCF4 activates gene expression. Highest gene expression obtained when SMAD1/b-catenin/TCF4 complex is formed PMID:15576399 s_wca3_re116(MAP:survival): Swi/SNF complex NuRD complex: b-catenin/CTBP/Hipk2/LEF1 complex PMID:17666529 s_wca3_re133(MAP:survival): MTA1 HDAC2 were shown together with NuRD to bind to six3-promoter region. PMID:20682799 References_end</body> </html> </notes> <label text="(Mi-2/NuRD)"/> <bbox w="182.0" h="171.0" x="14182.0" y="4968.0"/> <glyph class="macromolecule" id="wca1_wca3_s505_wca1_wca3_sa370"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: metastasis associated 1 HUGO:MTA1 HGNC:7410 ENTREZ:9112 UNIPROT:Q13330 GENECARDS:MTA1 ATLASONC:MTA1ID41443ch14q32 WIKI:MTA1 metastasis associated 2 HUGO:MTA2 HGNC:7411 ENTREZ:9219 UNIPROT:O94776 GENECARDS:MTA2 KEGG:9219 ATLASONC:GC_MTA2 WIKI:MTA2 metastasis associated 3 HUGO:MTA3 HGNC:23784 ENTREZ:57504 UNIPROT:Q9BTC8 GENECARDS:MTA3 ATLASONC:MTA3ID41445ch2p21 WIKI:MTA3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: MTA1 and MTA3 have opposing roles in transcripton of SNAI1: MTA1 induces while MTA3 inhibits PMID:21734722 References_end</body> </html> </notes> <label text="MTA1_2_3*"/> <bbox w="80.0" h="40.0" x="14275.0" y="5026.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s506_wca1_wca3_sa371"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: chromodomain helicase DNA binding protein 3 HUGO:CHD3 HGNC:1918 ENTREZ:1107 UNIPROT:Q12873 GENECARDS:CHD3 KEGG:1107 ATLASONC:GC_CHD3 WIKI:CHD3 chromodomain helicase DNA binding protein 4 HUGO:CHD4 HGNC:1919 ENTREZ:1108 UNIPROT:Q14839 GENECARDS:CHD4 KEGG:1108 ATLASONC:GC_CHD4 WIKI:CHD4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CHD3_4*"/> <bbox w="80.0" h="40.0" x="14275.0" y="4983.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s511_wca1_wca3_sa372"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: histone deacetylase 1 HUGO:HDAC1 HGNC:4852 ENTREZ:3065 UNIPROT:Q13547 GENECARDS:HDAC1 REACTOME:56408 KEGG:3065 ATLASONC:GC_HDAC1 WIKI:HDAC1 HUGO:HDAC2 HGNC:4853 ENTREZ:3066 UNIPROT:Q92769 GENECARDS:HDAC2 REACTOME:56410 KEGG:3066 ATLASONC:HDAC2ID40803ch6q22 WIKI:HDAC2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HDAC1_2*"/> <bbox w="80.0" h="40.0" x="14192.0" y="4983.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s508_wca1_wca3_sa374"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: methyl-CpG binding domain protein 2 HUGO:MBD2 HGNC:6917 ENTREZ:8932 UNIPROT:Q9UBB5 GENECARDS:MBD2 REACTOME:150076 KEGG:8932 ATLASONC:MBD2ID41309ch18q21 WIKI:MBD2 methyl-CpG binding domain protein 3 HUGO:MBD3 HGNC:6918 ENTREZ:53615 UNIPROT:O95983 GENECARDS:MBD3 ATLASONC:GC_MBD3 WIKI:MBD3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MBD2_3*"/> <bbox w="80.0" h="40.0" x="14192.0" y="5026.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s509_wca1_wca3_sa375"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: retinoblastoma binding protein 4 HUGO:RBBP4 HGNC:9887 ENTREZ:5928 UNIPROT:Q09028 GENECARDS:RBBP4 REACTOME:62836 KEGG:5928 ATLASONC:GC_RBBP4 WIKI:RBBP4 retinoblastoma binding protein 7 HUGO:RBBP7 HGNC:9890 ENTREZ:5931 UNIPROT:Q16576 GENECARDS:RBBP7 REACTOME:62840 KEGG:5931 ATLASONC:RBBP7ID42065chXp22 WIKI:RBBP7 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RBBP4_7*"/> <bbox w="80.0" h="40.0" x="14192.0" y="5070.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s510_wca1_wca3_sa376"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: GATA zinc finger domain containing 2A HUGO:GATAD2A HGNC:29989 ENTREZ:54815 UNIPROT:Q86YP4 GENECARDS:GATAD2A KEGG:54815 WIKI:GATAD2A GATA zinc finger domain containing 2B HUGO:GATADB GENECARDS:GATADB WIKI:GATADB Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="GATAD2A_B*"/> <bbox w="80.0" h="40.0" x="14275.0" y="5070.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s800_wca1_wca3_csa7" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAF*:BAF155*:BAF180*:BAF250*:BAF45A*:BAF47*:BAF53A*:BAF57*:BAF60A*:BRD7:BRG1*:_beta_-actin* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: ATP-dependent chromatin-remodeling complex PMID:21358755 s_wca3_re44(MAP:survival): Mi-2/NuRD PMID:22290435 SWI/SNF s_wca3_re116(MAP:survival): PMID:22761862 Swi/SNF complex NuRD complex: b-catenin/CTBP/Hipk2/LEF1 complex PMID:17666529 References_end</body> </html> </notes> <label text="(SWI/SNF)"/> <bbox w="262.0" h="198.0" x="14386.0" y="4943.0"/> <glyph class="macromolecule" id="wca1_wca3_s60_wca1_wca3_sa53"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: barrier to autointegration factor 1 HUGO:BANF1 HGNC:17397 ENTREZ:8815 UNIPROT:O75531 GENECARDS:BANF1 REACTOME:50669 KEGG:8815 WIKI:BANF1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BAF*"/> <bbox w="80.0" h="40.0" x="14398.0" y="4948.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s61_wca1_wca3_sa54"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily a member 4 SNF2L4 HUGO:SMARCA4 HGNC:11100 ENTREZ:6597 UNIPROT:P51532 GENECARDS:SMARCA4 KEGG:6597 ATLASONC:SMARCA4ID42333ch19p13 WIKI:SMARCA4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BRG1*"/> <bbox w="80.0" h="40.0" x="14478.0" y="4948.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s62_wca1_wca3_sa55"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: AT rich interactive domain 1A (SWI-like) "AT rich interactive domain 1A (SWI- like)" C1orf4 SMARCF1 "SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily f member 1" HUGO:ARID1A HGNC:11110 ENTREZ:8289 UNIPROT:O14497 GENECARDS:ARID1A KEGG:8289 ATLASONC:GC_ARID1A WIKI:ARID1A Identifiers_end Maps_Modules_begin: MAP:cellcycle / MODULE:RB MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BAF250*"/> <bbox w="80.0" h="40.0" x="14559.0" y="4948.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s63_wca1_wca3_sa56"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polybromo 1 HUGO:PBRM1 HGNC:30064 ENTREZ:55193 UNIPROT:Q86U86 GENECARDS:PBRM1 KEGG:55193 ATLASONC:GC_PBRM1 WIKI:PBRM1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BAF180*"/> <bbox w="80.0" h="40.0" x="14398.0" y="4989.3335"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s64_wca1_wca3_sa57"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily c member 1 HUGO:SMARCC1 HGNC:11104 ENTREZ:6599 UNIPROT:Q92922 GENECARDS:SMARCC1 KEGG:6599 ATLASONC:GC_SMARCC1 WIKI:SMARCC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BAF155*"/> <bbox w="80.0" h="40.0" x="14478.0" y="4989.3335"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s65_wca1_wca3_sa58"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily d member 1 HUGO:SMARCD1 HGNC:11106 ENTREZ:6602 UNIPROT:Q96GM5 GENECARDS:SMARCD1 KEGG:6602 ATLASONC:GC_SMARCD1 WIKI:SMARCD1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BAF60A*"/> <bbox w="80.0" h="40.0" x="14559.0" y="4989.3335"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s66_wca1_wca3_sa59"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: actin-like 6A HUGO:ACTL6A HGNC:24124 ENTREZ:86 UNIPROT:O96019 GENECARDS:ACTL6A KEGG:86 ATLASONC:GC_ACTL6A WIKI:ACTL6A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BAF53A*"/> <bbox w="80.0" h="40.0" x="14398.0" y="5030.6665"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s67_wca1_wca3_sa60"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily b member 1 SNF5L1 HUGO:SMARCB1 HGNC:11103 ENTREZ:6598 UNIPROT:Q12824 GENECARDS:SMARCB1 KEGG:6598 ATLASONC:SMARCB1ID169 WIKI:SMARCB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BAF47*"/> <bbox w="80.0" h="40.0" x="14478.0" y="5030.6665"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s68_wca1_wca3_sa61"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: PHD finger protein 10 HUGO:PHF10 HGNC:18250 ENTREZ:55274 UNIPROT:Q8WUB8 GENECARDS:PHF10 KEGG:55274 ATLASONC:GC_PHF10 WIKI:PHF10 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BAF45A*"/> <bbox w="80.0" h="40.0" x="14559.0" y="5030.6665"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s69_wca1_wca3_sa62"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily e member 1 HUGO:SMARCE1 HGNC:11109 ENTREZ:6605 UNIPROT:Q969G3 GENECARDS:SMARCE1 KEGG:6605 ATLASONC:GC_SMARCE1 WIKI:SMARCE1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BAF57*"/> <bbox w="80.0" h="40.0" x="14398.0" y="5072.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s70_wca1_wca3_sa63"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: actin beta HUGO:ACTB HGNC:132 ENTREZ:60 UNIPROT:P60709 GENECARDS:ACTB REACTOME:49576 KEGG:60 ATLASONC:ACTBID42959ch7p22 WIKI:ACTB Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="β-actin*"/> <bbox w="80.0" h="40.0" x="14478.0" y="5072.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s71_wca1_wca3_sa64"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: bromodomain containing 7 "bromodomain-containing 7" HUGO:BRD7 HGNC:14310 ENTREZ:29117 UNIPROT:Q9NPI1 GENECARDS:BRD7 KEGG:29117 ATLASONC:GC_BRD7 WIKI:BRD7 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BRD7"/> <bbox w="80.0" h="40.0" x="14559.0" y="5072.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s801_wca1_wca3_csa67" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:APC1*:APC10*:APC11*:APC12*:APC13*:APC2*:APC3*:APC4*:APC5*:APC6*:APC7*:APC8*:CDC20 Identifiers_end References_begin: CDC20 targets AXIN2 PMID:22322943 Composition APC/C complex PMID:16896351 References_end</body> </html> </notes> <label text="(APC/C/CDC20)"/> <bbox w="351.0" h="216.0" x="14661.0" y="4896.0"/> <glyph class="macromolecule" id="wca1_wca3_s593_wca1_wca3_sa419"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 1 HUGO:ANAPC1 HGNC:19988 ENTREZ:64682 UNIPROT:Q9H1A4 GENECARDS:ANAPC1 REACTOME:84973 KEGG:64682 ATLASONC:GC_ANAPC1 WIKI:ANAPC1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="APC1*"/> <bbox w="80.0" h="40.0" x="14671.0" y="4913.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s594_wca1_wca3_sa420"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC2 HGNC:19989 ENTREZ:29882 UNIPROT:Q9UJX6 GENECARDS:ANAPC2 REACTOME:84976 KEGG:29882 ATLASONC:GC_ANAPC2 WIKI:ANAPC2 axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: anaphase promoting complex subunit 2 HUGO:ANAPC2 HGNC:19989 ENTREZ:29882 UNIPROT:Q9UJX6 GENECARDS:ANAPC2 REACTOME:84976 KEGG:29882 ATLASONC:GC_ANAPC2 WIKI:ANAPC2 axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="APC2*"/> <bbox w="80.0" h="40.0" x="14671.0" y="4957.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s595_wca1_wca3_sa421"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 27 "cell division cycle 27" "cell division cycle 27 homolog (S. cerevisiae)" D17S978E D0S1430E HUGO:CDC27 HGNC:1728 ENTREZ:996 UNIPROT:P30260 GENECARDS:CDC27 REACTOME:69811 KEGG:996 ATLASONC:GC_CDC27 WIKI:CDC27 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="APC3*"/> <bbox w="80.0" h="40.0" x="14671.0" y="5000.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s596_wca1_wca3_sa422"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 4 HUGO:ANAPC4 HGNC:19990 ENTREZ:29945 UNIPROT:Q9UJX5 GENECARDS:ANAPC4 REACTOME:84978 KEGG:29945 WIKI:ANAPC4 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="APC4*"/> <bbox w="80.0" h="40.0" x="14671.0" y="5044.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s597_wca1_wca3_sa423"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 16 "CDC16 (cell division cycle 16 S. cerevisiae homolog)" "CDC16 cell division cycle 16 homolog (S. cerevisiae)" "cell division cycle 16 homolog (S. cerevisiae)" HUGO:CDC16 HGNC:1720 ENTREZ:8881 UNIPROT:Q13042 GENECARDS:CDC16 REACTOME:86748 KEGG:8881 ATLASONC:GC_CDC16 WIKI:CDC16 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="APC6*"/> <bbox w="80.0" h="40.0" x="14755.0" y="4957.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s598_wca1_wca3_sa424"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 7 HUGO:ANAPC7 HGNC:17380 ENTREZ:51434 UNIPROT:Q9UJX3 GENECARDS:ANAPC7 REACTOME:84983 KEGG:51434 ATLASONC:GC_ANAPC7 WIKI:ANAPC7 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="APC7*"/> <bbox w="80.0" h="40.0" x="14755.0" y="5000.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s599_wca1_wca3_sa425"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 23 "CDC23 (cell division cycle 23 yeast homolog)" "cell division cycle 23 homolog (S. cerevisiae)" HUGO:CDC23 HGNC:1724 ENTREZ:8697 UNIPROT:Q9UJX2 GENECARDS:CDC23 REACTOME:86758 KEGG:8697 ATLASONC:GC_CDC23 WIKI:CDC23 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="APC8*"/> <bbox w="80.0" h="40.0" x="14755.0" y="5044.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s600_wca1_wca3_sa426"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 10 HUGO:ANAPC10 HGNC:24077 ENTREZ:10393 UNIPROT:Q9UM13 GENECARDS:ANAPC10 REACTOME:85074 KEGG:10393 WIKI:ANAPC10 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="APC10*"/> <bbox w="80.0" h="40.0" x="14839.0" y="4913.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s601_wca1_wca3_sa427"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 11 "anaphase promoting complex subunit 11 (yeast APC11 homolog)" HUGO:ANAPC11 HGNC:14452 ENTREZ:51529 UNIPROT:Q9NYG5 GENECARDS:ANAPC11 REACTOME:69640 KEGG:51529 WIKI:ANAPC11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="APC11*"/> <bbox w="80.0" h="40.0" x="14839.0" y="4957.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s602_wca1_wca3_sa428"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 26 C9orf17 "cell division cycle 26" "cell division cycle 26 homolog (S. cerevisiae)" "chromosome 9 open reading frame 17" HUGO:CDC26 HGNC:17839 ENTREZ:246184 UNIPROT:Q8NHZ8 GENECARDS:CDC26 REACTOME:177755 KEGG:246184 WIKI:CDC26 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="APC12*"/> <bbox w="80.0" h="40.0" x="14839.0" y="5000.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s603_wca1_wca3_sa429"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 13 HUGO:ANAPC13 HGNC:24540 ENTREZ:25847 UNIPROT:Q9BS18 GENECARDS:ANAPC13 REACTOME:218593 KEGG:25847 ATLASONC:GC_ANAPC13 WIKI:ANAPC13 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="APC13*"/> <bbox w="80.0" h="40.0" x="14839.0" y="5044.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s604_wca1_wca3_sa430"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: cell division cycle 20 "CDC20 (cell division cycle 20 S. cerevisiae homolog)" "CDC20 cell division cycle 20 homolog (S. cerevisiae)" "cell division cycle 20 homolog (S. cerevisiae)" HUGO:CDC20 HGNC:1723 ENTREZ:991 UNIPROT:Q12834 GENECARDS:CDC20 REACTOME:86754 KEGG:991 ATLASONC:CDC20ID40003ch1p34 WIKI:CDC20 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:M_CC_PHASE MAP:cellcycle / MODULE:APC MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CDC20"/> <bbox w="80.0" h="40.0" x="14923.0" y="5044.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s605_wca1_wca3_sa431"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: anaphase promoting complex subunit 5 HUGO:ANAPC5 HGNC:15713 ENTREZ:51433 UNIPROT:Q9UJX4 GENECARDS:ANAPC5 REACTOME:84980 KEGG:51433 ATLASONC:GC_ANAPC5 WIKI:ANAPC5 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:dnarepair / MODULE:M_CC_PHASE MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="APC5*"/> <bbox w="80.0" h="40.0" x="14755.0" y="4913.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s802_wca1_wca3_csa6" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ASH2L:DPY30:HCF2*:MLL2:Menin*:RBBP5:RPB2*:WDR5 Identifiers_end References_begin: PMID:17168535 References_end</body> </html> </notes> <label text="(MLL2)"/> <bbox w="184.0" h="190.0" x="14632.0" y="4688.0"/> <glyph class="macromolecule" id="wca1_wca3_s51_wca1_wca3_sa45"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: ash2 (absent small or homeotic)-like (Drosophila) "ash2 (absent small or homeotic Drosophila homolog)-like" ASH2L1 HUGO:ASH2L HGNC:744 ENTREZ:9070 UNIPROT:Q9UBL3 GENECARDS:ASH2L KEGG:9070 ATLASONC:ASH2LID44404ch8p11 WIKI:ASH2L Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ASH2L"/> <bbox w="80.0" h="40.0" x="14641.0" y="4691.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s52_wca1_wca3_sa46"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: retinoblastoma binding protein 5 "retinoblastoma-binding protein 5" HUGO:RBBP5 HGNC:9888 ENTREZ:5929 UNIPROT:Q15291 GENECARDS:RBBP5 KEGG:5929 ATLASONC:GC_RBBP5 WIKI:RBBP5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RBBP5"/> <bbox w="80.0" h="40.0" x="14724.0" y="4691.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s53_wca1_wca3_sa47"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: WD repeat domain 5 HUGO:WDR5 HGNC:12757 ENTREZ:11091 UNIPROT:P61964 GENECARDS:WDR5 KEGG:11091 ATLASONC:GC_WDR5 WIKI:WDR5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="WDR5"/> <bbox w="80.0" h="40.0" x="14641.0" y="4818.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s54_wca1_wca3_sa48"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: myeloid/lymphoid or mixed-lineage leukemia 2 TNRC21 "trinucleotide repeat containing 21" HUGO:MLL2 GENECARDS:MLL2 KEGG:9757 ATLASONC:GC_MLL2 WIKI:MLL2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MLL2"/> <bbox w="80.0" h="40.0" x="14641.0" y="4733.3335"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s55_wca1_wca3_sa49"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: polymerase (RNA) II (DNA directed) polypeptide B 140kDa "polymerase (RNA) II (DNA directed) polypeptide B (140kD)" HUGO:POLR2B HGNC:9188 ENTREZ:5431 UNIPROT:P30876 GENECARDS:POLR2B REACTOME:63505 KEGG:5431 ATLASONC:GC_POLR2B WIKI:POLR2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RPB2*"/> <bbox w="80.0" h="40.0" x="14724.0" y="4775.6665"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s56_wca1_wca3_sa50"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: host cell factor C2 HUGO:HCFC2 HGNC:24972 ENTREZ:29915 UNIPROT:Q9Y5Z7 GENECARDS:HCFC2 KEGG:29915 WIKI:HCFC2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HCF2*"/> <bbox w="80.0" h="40.0" x="14724.0" y="4818.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s57_wca1_wca3_sa51"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: dpy-30 homolog (C. elegans) HUGO:DPY30 HGNC:24590 ENTREZ:84661 UNIPROT:Q9C005 GENECARDS:DPY30 KEGG:84661 WIKI:DPY30 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="DPY30"/> <bbox w="80.0" h="40.0" x="14641.0" y="4775.6665"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s58_wca1_wca3_sa52"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: multiple endocrine neoplasia I HUGO:MEN1 HGNC:7010 ENTREZ:4221 UNIPROT:O00255 GENECARDS:MEN1 REACTOME:59151 KEGG:4221 ATLASONC:MEN1ID148 WIKI:MEN1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Menin*"/> <bbox w="80.0" h="40.0" x="14724.0" y="4733.3335"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s803_wca1_wca3_csa5" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Actin*:BAF53A*:BRD8:DMAP1:EAF6*:EPC1:GAS41*:H2AFX:H2AFZ:H2B*:ING3:MRG15*:MRGBP:Pontin*:Reptin*:TRRAP:YL1*:p400* Identifiers_end References_begin: PMID:17320397 References_end</body> </html> </notes> <label text="(Tip60)"/> <bbox w="264.0" h="276.0" x="14827.0" y="4600.0"/> <glyph class="macromolecule" id="wca1_wca3_s32_wca1_wca3_sa27"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transformation/transcription domain-associated protein HUGO:TRRAP HGNC:12347 ENTREZ:8295 UNIPROT:Q9Y4A5 GENECARDS:TRRAP KEGG:8295 ATLASONC:GC_TRRAP WIKI:TRRAP Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TRRAP"/> <bbox w="80.0" h="40.0" x="14999.0" y="4605.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s33_wca1_wca3_sa28"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: enhancer of polycomb homolog 1 (Drosophila) HUGO:EPC1 HGNC:19876 ENTREZ:80314 UNIPROT:Q9H2F5 GENECARDS:EPC1 KEGG:80314 ATLASONC:GC_EPC1 WIKI:EPC1 Identifiers_end Maps_Modules_begin: MAP:cellcycle / MODULE:E2F6 MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="EPC1"/> <bbox w="80.0" h="40.0" x="14918.0" y="4605.6"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s34_wca1_wca3_sa29"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: mortality factor 4 like 1 HUGO:MORF4L1 HGNC:16989 ENTREZ:10933 UNIPROT:Q9UBU8 GENECARDS:MORF4L1 KEGG:10933 ATLASONC:GC_MORF4L1 WIKI:MORF4L1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MRG15*"/> <bbox w="80.0" h="40.0" x="14921.0" y="4689.2"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s35_wca1_wca3_sa30"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MYST/Esa1-associated factor 6 C1orf149 "chromosome 1 open reading frame 149" HUGO:MEAF6 HGNC:25674 ENTREZ:64769 UNIPROT:Q9HAF1 GENECARDS:MEAF6 KEGG:64769 ATLASONC:GC_MEAF6 WIKI:MEAF6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="EAF6*"/> <bbox w="80.0" h="40.0" x="14921.0" y="4731.8"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s36_wca1_wca3_sa31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: inhibitor of growth family member 3 HUGO:ING3 HGNC:14587 ENTREZ:54556 UNIPROT:Q9NXR8 GENECARDS:ING3 KEGG:54556 ATLASONC:GC_ING3 WIKI:ING3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ING3"/> <bbox w="80.0" h="40.0" x="14921.0" y="4774.4"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s37_wca1_wca3_sa32"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: E1A binding protein p400 TNRC12 "trinucleotide repeat containing 12" HUGO:EP400 HGNC:11958 ENTREZ:57634 UNIPROT:Q96L91 GENECARDS:EP400 KEGG:57634 ATLASONC:EP400ID40457ch12q24 WIKI:EP400 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="p400*"/> <bbox w="80.0" h="40.0" x="15002.0" y="4646.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s38_wca1_wca3_sa33"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: bromodomain containing 8 HUGO:BRD8 HGNC:19874 ENTREZ:10902 UNIPROT:Q9H0E9 GENECARDS:BRD8 KEGG:10902 ATLASONC:GC_BRD8 WIKI:BRD8 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BRD8"/> <bbox w="80.0" h="40.0" x="14918.0" y="4647.6"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s39_wca1_wca3_sa34"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: MRG/MORF4L binding protein C20orf20 "chromosome 20 open reading frame 20" HUGO:MRGBP HGNC:15866 ENTREZ:55257 UNIPROT:Q9NV56 GENECARDS:MRGBP KEGG:55257 ATLASONC:GC_MRGBP WIKI:MRGBP Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MRGBP"/> <bbox w="80.0" h="40.0" x="15004.0" y="4689.2"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s40_wca1_wca3_sa35"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: actin alpha 1 skeletal muscle NEM3 "nemaline myopathy type 3" HUGO:ACTA1 HGNC:129 ENTREZ:58 UNIPROT:P68133 GENECARDS:ACTA1 REACTOME:49626 KEGG:58 ATLASONC:GC_ACTA1 WIKI:ACTA1 actin beta HUGO:ACTB HGNC:132 ENTREZ:60 UNIPROT:P60709 GENECARDS:ACTB REACTOME:49576 KEGG:60 ATLASONC:ACTBID42959ch7p22 WIKI:ACTB actin gamma 1 HUGO:ACTG1 HGNC:144 ENTREZ:71 UNIPROT:P63261 GENECARDS:ACTG1 REACTOME:49603 KEGG:71 ATLASONC:GC_ACTG1 WIKI:ACTG1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Actin*"/> <bbox w="80.0" h="40.0" x="15004.0" y="4731.8"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s41_wca1_wca3_sa36"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: H2A histone family member X HUGO:H2AFX HGNC:4739 ENTREZ:3014 UNIPROT:P16104 GENECARDS:H2AFX REACTOME:56152 KEGG:3014 ATLASONC:H2AFXID40783ch11q23 WIKI:H2AFX Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="H2AFX"/> <bbox w="80.0" h="40.0" x="15004.0" y="4774.4"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s42_wca1_wca3_sa37"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: vacuolar protein sorting 72 homolog (S. cerevisiae) TCFL1 "transcription factor-like 1" "vacuolar protein sorting 72 (yeast)" HUGO:VPS72 HGNC:11644 ENTREZ:6944 UNIPROT:Q15906 GENECARDS:VPS72 KEGG:6944 ATLASONC:GC_VPS72 WIKI:VPS72 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="YL1*"/> <bbox w="80.0" h="40.0" x="14837.0" y="4605.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s43_wca1_wca3_sa38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: H2A histone family member Z H2AZ HUGO:H2AFZ HGNC:4741 ENTREZ:3015 UNIPROT:P0C0S5 GENECARDS:H2AFZ REACTOME:231437 KEGG:3015 ATLASONC:GC_H2AFZ WIKI:H2AFZ Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="H2AFZ"/> <bbox w="80.0" h="40.0" x="14837.0" y="4646.6"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s44_wca1_wca3_sa39"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: DNA methyltransferase 1 associated protein 1 HUGO:DMAP1 HGNC:18291 ENTREZ:55929 UNIPROT:Q9NPF5 GENECARDS:DMAP1 KEGG:55929 ATLASONC:GC_DMAP1 WIKI:DMAP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="DMAP1"/> <bbox w="80.0" h="40.0" x="14837.0" y="4689.2"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s45_wca1_wca3_sa40"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: YEATS domain containing 4 HUGO:YEATS4 HGNC:24859 ENTREZ:8089 UNIPROT:O95619 GENECARDS:YEATS4 KEGG:8089 ATLASONC:GC_YEATS4 WIKI:YEATS4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="GAS41*"/> <bbox w="80.0" h="40.0" x="14837.0" y="4731.8"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s46_wca1_wca3_sa41"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: actin-like 6A HUGO:ACTL6A HGNC:24124 ENTREZ:86 UNIPROT:O96019 GENECARDS:ACTL6A KEGG:86 ATLASONC:GC_ACTL6A WIKI:ACTL6A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BAF53A*"/> <bbox w="80.0" h="40.0" x="14837.0" y="4774.4"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s47_wca1_wca3_sa42"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: histone cluster 2 H2be H2B "H2B histone family member Q" H2BFQ "histone 2 H2be" HUGO:HIST2H2BE HGNC:4760 ENTREZ:8349 UNIPROT:Q16778 GENECARDS:HIST2H2BE REACTOME:56186 KEGG:8349 ATLASONC:GC_HIST2H2BE WIKI:HIST2H2BE Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="H2B*"/> <bbox w="80.0" h="40.0" x="14921.0" y="4817.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s48_wca1_wca3_sa43"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RuvB-like 1 (E. coli) "RuvB (E coli homolog)-like 1" HUGO:RUVBL1 HGNC:10474 ENTREZ:8607 UNIPROT:Q9Y265 GENECARDS:RUVBL1 REACTOME:63862 KEGG:8607 ATLASONC:RUVBL1ID44415ch3q21 WIKI:RUVBL1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Pontin*"/> <bbox w="80.0" h="40.0" x="14837.0" y="4817.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s50_wca1_wca3_sa44"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: RuvB-like 2 (E. coli) "RuvB (E coli homolog)-like 2" HUGO:RUVBL2 HGNC:10475 ENTREZ:10856 UNIPROT:Q9Y230 GENECARDS:RUVBL2 REACTOME:63864 KEGG:10856 ATLASONC:RUVBL2ID42185ch19q13 WIKI:RUVBL2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Reptin*"/> <bbox w="80.0" h="40.0" x="15003.0" y="4817.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s804_wca1_wca3_csa22" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HDAC1_2*:LEF_TCF*:TLE*:WRE* Identifiers_end References_begin: PMID:11266540 s_wca3_re111:(MAP:survival) PMID:16510874 s_wca3_re147(MAP:survival): Phosphorylated TCF/LEF transcription factor dissociates and is replaced by another unphosphorylated one. For example TCF3 (repressor) is phosphorylated by HIPK2 and will dissociate from the complex and is replaced by TCF1. PMID:21285352 s_wca3_re7(MAP:survival): The transcription complex containing P300 initiates transcription of genes that are involved in differentiation. PMID:20920541 The repressor complex is is by default present on the enhancers of wnt-target genes PMID:16510874 s_wca3_re40(MAP:survival): Not sure if ubiquitination by XIAP is necessary for replacement of TLE by b-catenin upon canonical WNT signaling PMID:22304967 s_wca3_re125(MAP:survival): CBP-mediated transcription effects genes that are involved in stemm cell or progenitor cell maintenance and proliferation Repressor complex is default present on the enhance of wnt-target genes s_wca3_re146(MAP:survival): HIPK2 phosphorylates any TCF/LEF References_end</body> </html> </notes> <label text="(Repressor_complex)"/> <bbox w="101.0" h="187.0" x="14416.5" y="4261.5"/> <glyph class="nucleic acid feature" id="wca1_wca3_s131_wca1_wca3_sa162"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: WNT responsive element References_end</body> </html> </notes> <label text="WRE*"/> <bbox w="70.0" h="25.0" x="14431.5" y="4393.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s132_wca1_wca3_sa163"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>TCF family: tcf-1, lef-1, tcf-3, tcf-4 PMID:11266540 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 transcription factor 7-like 1 (T-cell specific HMG-box) TCF3 HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 transcription factor 7-like 2 (T-cell specific HMG-box) TCF4 HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end</body> </html> </notes> <label text="LEF_TCF*"/> <bbox w="80.0" h="40.0" x="14426.5" y="4352.5"/> <glyph class="state variable" id="_9c9e21c8-61da-4761-a124-137a2ac624b0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14501.5" y="4348.378"/> </glyph> <glyph class="state variable" id="_f41f7362-acc0-4ff6-97f0-4cc1c3371a4b"> <state value="" variable="S40"/> <bbox w="25.0" h="10.0" x="14494.0" y="4384.1143"/> </glyph> <glyph class="state variable" id="_934dc239-06b1-457f-9f4d-45e2f5a5ce7a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14501.5" y="4367.5"/> </glyph> <glyph class="state variable" id="_95684830-947b-47e6-a625-6082a0337b9c"> <state value="" variable="S166"/> <bbox w="30.0" h="10.0" x="14411.992" y="4347.5"/> </glyph> <glyph class="state variable" id="_24fd9c08-dcb3-45b9-8c7d-19540396ea4e"> <state value="" variable="T155"/> <bbox w="30.0" h="10.0" x="14411.5" y="4387.222"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s133_wca1_wca3_sa164"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transducin-like enhancer of split 1 (E(sp1) homolog Drosophila) "transducin-like enhancer of split 1 homolog of Drosophila E(sp1)" HUGO:TLE1 HGNC:11837 ENTREZ:7088 UNIPROT:Q04724 GENECARDS:TLE1 REACTOME:66083 KEGG:7088 ATLASONC:GC_TLE1 WIKI:TLE1 transducin-like enhancer of split 2 (E(sp1) homolog Drosophila) HUGO:TLE2 HGNC:11838 ENTREZ:7089 UNIPROT:Q04725 GENECARDS:TLE2 REACTOME:66085 KEGG:7089 WIKI:TLE2 transducin-like enhancer of split 3 (E(sp1) homolog Drosophila) HUGO:TLE3 HGNC:11839 ENTREZ:7090 UNIPROT:Q04726 GENECARDS:TLE3 REACTOME:405165 KEGG:7090 ATLASONC:GC_TLE3 WIKI:TLE3 transducin-like enhancer of split 4 (E(sp1) homolog Drosophila) HUGO:TLE4 HGNC:11840 ENTREZ:7091 UNIPROT:Q04727 GENECARDS:TLE4 REACTOME:66089 KEGG:7091 WIKI:TLE4 amino-terminal enhancer of split GRG5 TLE5 HUGO:AES HGNC:307 ENTREZ:166 UNIPROT:Q08117 GENECARDS:AES KEGG:166 ATLASONC:GC_AES WIKI:AES transducin-like enhancer of split 6 (E(sp1) homolog Drosophila) HUGO:TLE6 HGNC:30788 ENTREZ:79816 UNIPROT:Q9H808 GENECARDS:TLE6 KEGG:79816 ATLASONC:GC_TLE6 WIKI:TLE6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: References_begin non-DNA binding transcription factor PMID:20925119 References-end References_end</body> </html> </notes> <label text="TLE*"/> <bbox w="80.0" h="40.0" x="14426.5" y="4310.5"/> <glyph class="state variable" id="_34754ac0-6029-4682-907f-0f08f38b67e7"> <state value="" variable="S239"/> <bbox w="30.0" h="10.0" x="14411.992" y="4305.5"/> </glyph> <glyph class="state variable" id="_51aea6db-0831-4e6a-9072-1b827ac274bc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14501.5" y="4305.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s134_wca1_wca3_sa165"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: histone deacetylase 1 HUGO:HDAC1 HGNC:4852 ENTREZ:3065 UNIPROT:Q13547 GENECARDS:HDAC1 REACTOME:56408 KEGG:3065 ATLASONC:GC_HDAC1 WIKI:HDAC1 HUGO:HDAC2 HGNC:4853 ENTREZ:3066 UNIPROT:Q92769 GENECARDS:HDAC2 REACTOME:56410 KEGG:3066 ATLASONC:HDAC2ID40803ch6q22 WIKI:HDAC2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HDAC1_2*"/> <bbox w="80.0" h="40.0" x="14426.5" y="4269.5"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s805_wca1_wca3_csa1" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HDAC1_2*:LEF_TCF*:TLE*:WRE* Identifiers_end References_begin: PMID:11266540 s_wca3_re40(MAP:survival): Not sure if ubiquitination by XIAP is necessary for replacement of TLE by b-catenin upon canonical WNT signaling PMID:22304967 s_wca3_re6(MAP:survival): PMID:16169192 B-catenin competes with TLE for Lef-1 PMID:15768032 CBP-and P300-mediated transcription different cell fates PMID:20530697 (phosphorylated) C-JUN can bind to TCF4 PMID:18347071 PMID:16007074 References_end</body> </html> </notes> <label text="(Repressor_complex)"/> <bbox w="101.0" h="187.0" x="14223.4375" y="4326.125"/> <glyph class="nucleic acid feature" id="wca1_wca3_s209_wca1_wca3_sa6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: WNT responsive element References_end</body> </html> </notes> <label text="WRE*"/> <bbox w="70.0" h="25.0" x="14238.4375" y="4455.625"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s210_wca1_wca3_sa7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>TCF family: tcf-1, lef-1, tcf-3, tcf-4 PMID:11266540 ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 transcription factor 7-like 1 (T-cell specific HMG-box) TCF3 HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 transcription factor 7-like 2 (T-cell specific HMG-box) TCF4 HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end</body> </html> </notes> <label text="LEF_TCF*"/> <bbox w="80.0" h="40.0" x="14233.4375" y="4417.125"/> <glyph class="state variable" id="_99204226-0d4e-495c-a76a-c9c2b450c2e9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14308.4375" y="4413.003"/> </glyph> <glyph class="state variable" id="_9feb9cb0-43a6-4e0c-ba52-8500900d88a3"> <state value="" variable="S40"/> <bbox w="25.0" h="10.0" x="14300.9375" y="4448.7393"/> </glyph> <glyph class="state variable" id="_edfdeb22-b87d-4d69-bd74-22dea78a2a51"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14308.4375" y="4432.125"/> </glyph> <glyph class="state variable" id="_39b2b4fb-11c0-4964-9674-840a491d24bf"> <state value="" variable="S166"/> <bbox w="30.0" h="10.0" x="14218.93" y="4412.125"/> </glyph> <glyph class="state variable" id="_b25a85a7-ca0f-4bcb-900b-c31124a38898"> <state value="" variable="T155"/> <bbox w="30.0" h="10.0" x="14218.4375" y="4451.847"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s212_wca1_wca3_sa9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transducin-like enhancer of split 1 (E(sp1) homolog Drosophila) "transducin-like enhancer of split 1 homolog of Drosophila E(sp1)" HUGO:TLE1 HGNC:11837 ENTREZ:7088 UNIPROT:Q04724 GENECARDS:TLE1 REACTOME:66083 KEGG:7088 ATLASONC:GC_TLE1 WIKI:TLE1 transducin-like enhancer of split 2 (E(sp1) homolog Drosophila) HUGO:TLE2 HGNC:11838 ENTREZ:7089 UNIPROT:Q04725 GENECARDS:TLE2 REACTOME:66085 KEGG:7089 WIKI:TLE2 transducin-like enhancer of split 3 (E(sp1) homolog Drosophila) HUGO:TLE3 HGNC:11839 ENTREZ:7090 UNIPROT:Q04726 GENECARDS:TLE3 REACTOME:405165 KEGG:7090 ATLASONC:GC_TLE3 WIKI:TLE3 transducin-like enhancer of split 4 (E(sp1) homolog Drosophila) HUGO:TLE4 HGNC:11840 ENTREZ:7091 UNIPROT:Q04727 GENECARDS:TLE4 REACTOME:66089 KEGG:7091 WIKI:TLE4 amino-terminal enhancer of split GRG5 TLE5 HUGO:AES HGNC:307 ENTREZ:166 UNIPROT:Q08117 GENECARDS:AES KEGG:166 ATLASONC:GC_AES WIKI:AES transducin-like enhancer of split 6 (E(sp1) homolog Drosophila) HUGO:TLE6 HGNC:30788 ENTREZ:79816 UNIPROT:Q9H808 GENECARDS:TLE6 KEGG:79816 ATLASONC:GC_TLE6 WIKI:TLE6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: References_begin non-DNA binding transcription factor PMID:20925119 References-end References_end</body> </html> </notes> <label text="TLE*"/> <bbox w="80.0" h="40.0" x="14233.4375" y="4375.125"/> <glyph class="state variable" id="_41ae6bff-b88c-4b86-8558-220533b838bb"> <state value="" variable="S239"/> <bbox w="30.0" h="10.0" x="14218.93" y="4370.125"/> </glyph> <glyph class="state variable" id="_2c943290-8318-422a-8a2d-8bc0c709514a"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="14303.4375" y="4370.125"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s211_wca1_wca3_sa10"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: histone deacetylase 1 HUGO:HDAC1 HGNC:4852 ENTREZ:3065 UNIPROT:Q13547 GENECARDS:HDAC1 REACTOME:56408 KEGG:3065 ATLASONC:GC_HDAC1 WIKI:HDAC1 HUGO:HDAC2 HGNC:4853 ENTREZ:3066 UNIPROT:Q92769 GENECARDS:HDAC2 REACTOME:56410 KEGG:3066 ATLASONC:HDAC2ID40803ch6q22 WIKI:HDAC2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HDAC1_2*"/> <bbox w="80.0" h="40.0" x="14233.4375" y="4334.125"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s806_wca1_wca3_csa66" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HDAC1_2*:LEF_TCF*:TLE*:WRE* Identifiers_end References_begin: PMID:11266540 s_wca3_re146(MAP:survival): HIPK2 phosphorylates any TCF/LEF PMID:21285352 s_wca3_re147(MAP:survival): Phosphorylated TCF/LEF transcription factor dissociates and is replaced by another unphosphorylated one. For example TCF3 (repressor) is phosphorylated by HIPK2 and will dissociate from the complex and is replaced by TCF1. References_end</body> </html> </notes> <label text="(Repressor_complex)"/> <bbox w="101.0" h="187.0" x="14581.5" y="4076.5"/> <glyph class="nucleic acid feature" id="wca1_wca3_s578_wca1_wca3_sa405"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: WNT responsive element References_end</body> </html> </notes> <label text="WRE*"/> <bbox w="70.0" h="25.0" x="14596.5" y="4208.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s581_wca1_wca3_sa406"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 transcription factor 7-like 1 (T-cell specific HMG-box) TCF3 HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 transcription factor 7-like 2 (T-cell specific HMG-box) TCF4 HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end</body> </html> Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end</body> </html> </notes> <label text="LEF_TCF*"/> <bbox w="80.0" h="40.0" x="14591.5" y="4167.5"/> <glyph class="state variable" id="_28663f15-e5ca-42a8-b423-9ed6ab2c7a09"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14666.5" y="4163.378"/> </glyph> <glyph class="state variable" id="_d1ef9b63-d6f0-4e4e-b5d6-d87187df941a"> <state value="" variable="S40"/> <bbox w="25.0" h="10.0" x="14659.0" y="4199.1143"/> </glyph> <glyph class="state variable" id="_fcbe36db-7cf9-427c-aa01-4286b69e8bff"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14664.0" y="4182.5"/> </glyph> <glyph class="state variable" id="_aae3da03-576e-4ff4-a7d6-de16edf8b230"> <state value="" variable="S166"/> <bbox w="30.0" h="10.0" x="14576.992" y="4162.5"/> </glyph> <glyph class="state variable" id="_c4a9fcb0-852e-4800-82e2-018b786eab09"> <state value="" variable="T155"/> <bbox w="30.0" h="10.0" x="14576.5" y="4202.222"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s579_wca1_wca3_sa407"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transducin-like enhancer of split 1 (E(sp1) homolog Drosophila) "transducin-like enhancer of split 1 homolog of Drosophila E(sp1)" HUGO:TLE1 HGNC:11837 ENTREZ:7088 UNIPROT:Q04724 GENECARDS:TLE1 REACTOME:66083 KEGG:7088 ATLASONC:GC_TLE1 WIKI:TLE1 transducin-like enhancer of split 2 (E(sp1) homolog Drosophila) HUGO:TLE2 HGNC:11838 ENTREZ:7089 UNIPROT:Q04725 GENECARDS:TLE2 REACTOME:66085 KEGG:7089 WIKI:TLE2 transducin-like enhancer of split 3 (E(sp1) homolog Drosophila) HUGO:TLE3 HGNC:11839 ENTREZ:7090 UNIPROT:Q04726 GENECARDS:TLE3 REACTOME:405165 KEGG:7090 ATLASONC:GC_TLE3 WIKI:TLE3 transducin-like enhancer of split 4 (E(sp1) homolog Drosophila) HUGO:TLE4 HGNC:11840 ENTREZ:7091 UNIPROT:Q04727 GENECARDS:TLE4 REACTOME:66089 KEGG:7091 WIKI:TLE4 amino-terminal enhancer of split GRG5 TLE5 HUGO:AES HGNC:307 ENTREZ:166 UNIPROT:Q08117 GENECARDS:AES KEGG:166 ATLASONC:GC_AES WIKI:AES transducin-like enhancer of split 6 (E(sp1) homolog Drosophila) HUGO:TLE6 HGNC:30788 ENTREZ:79816 UNIPROT:Q9H808 GENECARDS:TLE6 KEGG:79816 ATLASONC:GC_TLE6 WIKI:TLE6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: References_begin non-DNA binding transcription factor PMID:20925119 References-end References_end</body> </html> </notes> <label text="TLE*"/> <bbox w="80.0" h="40.0" x="14591.5" y="4125.5"/> <glyph class="state variable" id="_b6a25c44-17b3-4569-bc52-5db4ed9c2089"> <state value="" variable="S239"/> <bbox w="30.0" h="10.0" x="14576.992" y="4120.5"/> </glyph> <glyph class="state variable" id="_9a042405-1f29-4970-b595-238bdbb4c757"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14666.5" y="4120.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca3_s580_wca1_wca3_sa408"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: histone deacetylase 1 HUGO:HDAC1 HGNC:4852 ENTREZ:3065 UNIPROT:Q13547 GENECARDS:HDAC1 REACTOME:56408 KEGG:3065 ATLASONC:GC_HDAC1 WIKI:HDAC1 HUGO:HDAC2 HGNC:4853 ENTREZ:3066 UNIPROT:Q92769 GENECARDS:HDAC2 REACTOME:56410 KEGG:3066 ATLASONC:HDAC2ID40803ch6q22 WIKI:HDAC2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HDAC1_2*"/> <bbox w="80.0" h="40.0" x="14591.5" y="4084.5"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca3_s807_wca1_wca3_csa43" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK2_alpha_:CK2_alpha_*:CK2_beta_* Identifiers_end References_begin: s_wca3_re35(MAP:survival): CK2 phosphorylates TLE PMID:15367661 References_end</body> </html> </notes> <label text="(CK2)"/> <bbox w="80.0" h="107.0" x="14278.0" y="4000.5"/> <glyph class="macromolecule" id="wca1_wca3_s355_wca1_wca3_sa269"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 alpha 1 polypeptide HUGO:CSNK2A1 HGNC:2457 ENTREZ:1457 UNIPROT:P68400 GENECARDS:CSNK2A1 REACTOME:201673 KEGG:1457 ATLASONC:GC_CSNK2A1 WIKI:CSNK2A1 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 alpha 1 polypeptide HUGO:CSNK2A1 HGNC:2457 ENTREZ:1457 UNIPROT:P68400 GENECARDS:CSNK2A1 REACTOME:201673 KEGG:1457 ATLASONC:GC_CSNK2A1 WIKI:CSNK2A1 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2α*"/> <bbox w="30.0" h="30.0" x="14285.0" y="4015.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s356_wca1_wca3_sa270"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 alpha prime polypeptide HUGO:CSNK2A2 HGNC:2459 ENTREZ:1459 UNIPROT:P19784 GENECARDS:CSNK2A2 REACTOME:57879 KEGG:1459 ATLASONC:GC_CSNK2A2 WIKI:CSNK2A2 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 alpha prime polypeptide HUGO:CSNK2A2 HGNC:2459 ENTREZ:1459 UNIPROT:P19784 GENECARDS:CSNK2A2 REACTOME:57879 KEGG:1459 ATLASONC:GC_CSNK2A2 WIKI:CSNK2A2 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2α'*"/> <bbox w="30.0" h="30.0" x="14318.0" y="4015.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s808_wca1_wca3_sa271"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2β*"/> <bbox w="30.0" h="30.0" x="14285.0" y="4050.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca3_s808_wca1_wca3_sa272"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2β*"/> <bbox w="30.0" h="30.0" x="14318.0" y="4050.5"/> </glyph> </glyph> <glyph class="source and sink" id="wca1_s_wca3_s189_wca1_wca3_sa149" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <label text="26S"/> <bbox w="30.0" h="30.0" x="13764.0" y="4053.0"/> </glyph> <glyph class="source and sink" id="wca1_s_wca3_s557_wca1_wca3_sa398" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>null_begin: PMID:15708980 References_end null_end</body> </html> </notes> <label text="degradation"/> <bbox w="30.0" h="30.0" x="13184.0" y="4163.0"/> </glyph> <glyph class="source and sink" id="wca1_s_wca3_s610_wca1_wca3_sa436" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <label text="26S proteosome"/> <bbox w="30.0" h="30.0" x="15002.0" y="5201.25"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s30_wca1_wca3_sa25" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re7(MAP:survival): The transcription complex containing P300 initiates transcription of genes that are involved in differentiation. PMID:20920541 The repressor complex is is by default present on the enhancers of wnt-target genes PMID:16510874 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Gene under control of P300-mediated transcription*"/> <bbox w="70.0" h="25.0" x="14120.0" y="4553.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s141_wca1_wca3_sa109" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re19:(MAP:survival) PMID:16491118 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dickkopf 1 homolog (Xenopus laevis) "dickkopf (Xenopus laevis) homolog 1" HUGO:DKK1 HGNC:2891 ENTREZ:22943 UNIPROT:O94907 GENECARDS:DKK1 KEGG:22943 ATLASONC:DKK1ID44007ch10q11 WIKI:DKK1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="DKK1"/> <bbox w="70.0" h="25.0" x="13160.0" y="5217.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s199_wca1_wca3_sa159" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re38:(MAP:survival) PMID:18519670 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: transducin-like enhancer of split 1 (E(sp1) homolog Drosophila) "transducin-like enhancer of split 1 homolog of Drosophila E(sp1)" HUGO:TLE1 HGNC:11837 ENTREZ:7088 UNIPROT:Q04724 GENECARDS:TLE1 REACTOME:66083 KEGG:7088 ATLASONC:GC_TLE1 WIKI:TLE1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TLE1"/> <bbox w="70.0" h="25.0" x="13160.0" y="5177.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s214_wca1_wca3_sa168" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re41:(MAP:survival) PMID:22045851 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 34a MIRN34A HUGO:MIR34A HGNC:31635 ENTREZ:407040 GENECARDS:MIR34A KEGG:407040 ATLASONC:GC_MIR34A WIKI:MIR34A Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR34A"/> <bbox w="70.0" h="25.0" x="13160.0" y="4768.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s216_wca1_wca3_sa170" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re42:(MAP:survival) PMID:22045851 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 34b MIRN34B HUGO:MIR34B HGNC:31636 ENTREZ:407041 GENECARDS:MIR34B KEGG:407041 ATLASONC:GC_MIR34B WIKI:MIR34B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR34B"/> <bbox w="70.0" h="25.0" x="13160.0" y="4802.2144"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s218_wca1_wca3_sa172" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re43:(MAP:survival) PMID:22045851 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 34c MIRN34C HUGO:MIR34C HGNC:31637 ENTREZ:407042 GENECARDS:MIR34C KEGG:407042 ATLASONC:GC_MIR34C WIKI:MIR34C Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR34C"/> <bbox w="70.0" h="25.0" x="13160.0" y="4835.9287"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s237_wca1_wca3_sa185" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re44(MAP:survival): Mi-2/NuRD PMID:22290435 SWI/SNF References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LEF1"/> <bbox w="70.0" h="25.0" x="13160.0" y="4869.6426"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s238_wca1_wca3_sa186" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re45:(MAP:survival) PMID:20710043 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 1 INT1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="WNT1"/> <bbox w="70.0" h="25.0" x="13160.0" y="4903.3574"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s239_wca1_wca3_sa187" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: wingless-type MMTV integration site family member 3 INT4 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="WNT3"/> <bbox w="70.0" h="25.0" x="13160.0" y="4937.0713"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s240_wca1_wca3_sa188" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LRP6"/> <bbox w="70.0" h="25.0" x="13160.0" y="4970.7856"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s241_wca1_wca3_sa189" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re22(MAP:survival): c-Raf; MEK1/2; ERK1/2;HRAS PMID:19906679 TGF-b1 in airway smooth muscle cells PMID:21908588 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: catenin (cadherin-associated protein) beta 1 HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: catenin (cadherin-associated protein) beta 1 HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="70.0" h="25.0" x="13160.0" y="5004.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s258_wca1_wca3_sa205" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) "v-myc avian myelocytomatosis viral oncogene homolog" HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) "v-myc avian myelocytomatosis viral oncogene homolog" HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 GENECARDS:MYC REACTOME:59773 KEGG:4609 ATLASONC:MYCID27 WIKI:MYC Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) "v-myc avian myelocytomatosis viral oncogene homolog" HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 GENECARDS:MYC REACTOME:59773 KEGG:4609 ATLASONC:MYCID27 WIKI:MYC Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MYC"/> <bbox w="70.0" h="25.0" x="14745.0" y="4396.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s266_wca1_wca3_sa211" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re69(MAP:survival): Synergistic effect on HES1 transcription PMID:19000719 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: hairy and enhancer of split 1 (Drosophila) "hairy homolog (Drosophila)" HRY HUGO:HES1 HGNC:5192 ENTREZ:3280 UNIPROT:Q14469 GENECARDS:HES1 REACTOME:56466 KEGG:3280 ATLASONC:GC_HES1 WIKI:HES1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HES1"/> <bbox w="70.0" h="25.0" x="14304.0" y="3755.0"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s272_wca1_wca3_sa216" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: nitric oxide synthase 2 inducible "nitric oxide synthase 2A (inducible hepatocytes)" NOS2A HUGO:NOS2 HGNC:7873 ENTREZ:4843 UNIPROT:P35228 GENECARDS:NOS2 REACTOME:60486 KEGG:4843 ATLASONC:GC_NOS2 WIKI:NOS2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="NOS2"/> <bbox w="70.0" h="25.0" x="14588.0" y="3807.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s387_wca1_wca3_sa292" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re127:(MAP:survival) PMID:19901072 PMID:19751731 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: WNT responsive element References_end</body> </html> </notes> <label text="WRE*"/> <bbox w="70.0" h="25.0" x="14176.5" y="4024.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s421_wca1_wca3_sa324" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re113:(MAP:survival) PMID:21416054 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Kruppel-like factor 4 (gut) HUGO:KLF4 HGNC:6348 ENTREZ:9314 UNIPROT:O43474 GENECARDS:KLF4 REACTOME:58119 KEGG:9314 ATLASONC:KLF4ID44316ch9q31 WIKI:KLF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="KLF4"/> <bbox w="70.0" h="25.0" x="13403.0" y="5184.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s448_wca1_wca3_sa337" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 "B-cell CLL/lymphoma 1" "G1/S-specific cyclin D1" "parathyroid adenomatosis 1" U21B31 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18414028 PMID:20673124 PMID:19887899 References_end Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 "B-cell CLL/lymphoma 1" "G1/S-specific cyclin D1" "parathyroid adenomatosis 1" U21B31 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18414028 PMID:20673124 PMID:19887899 References_end</body> </html> Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 "B-cell CLL/lymphoma 1" "G1/S-specific cyclin D1" "parathyroid adenomatosis 1" U21B31 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18414028 PMID:20673124 PMID:19887899 References_end</body> </html> </notes> <label text="CyclinD*"/> <bbox w="70.0" h="25.0" x="14745.0" y="4437.0"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s450_wca1_wca3_sa339" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re117:(MAP:survival) PMID:22761862 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="AXIN1"/> <bbox w="70.0" h="25.0" x="14745.0" y="4477.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s464_wca1_wca3_sa346" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re121:(MAP:survival) PMID:21416054 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) UVO HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="70.0" h="25.0" x="13403.0" y="5225.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s466_wca1_wca3_sa348" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re122(MAP:survival): Not sure if this mechanism is exact the same as for CYCLIND Myc and AXIN1 transcription. However it has been shown that KLF8 and b-catenin induces transcription of MMP9 gene. PMID:21151179 PMID:17306568 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: matrix metallopeptidase 9 (gelatinase B 92kDa gelatinase 92kDa type IV collagenase) CLG4B "matrix metalloproteinase 9 (gelatinase B 92kD gelatinase 92kD type IV collagenase)" "matrix metalloproteinase 9 (gelatinase B 92kDa gelatinase 92kDa type IV collagenase)" HUGO:MMP9 HGNC:7176 ENTREZ:4318 UNIPROT:P14780 GENECARDS:MMP9 REACTOME:59395 KEGG:4318 ATLASONC:MMP9ID41408ch20q11 WIKI:MMP9 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:ECM MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MMP9"/> <bbox w="70.0" h="25.0" x="14746.0" y="4516.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s478_wca1_wca3_sa358" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re125(MAP:survival): CBP-mediated transcription effects genes that are involved in stemm cell or progenitor cell maintenance and proliferation PMID:20920541 Repressor complex is default present on the enhance of wnt-target genes PMID:16510874 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Genes under control of CBP-mediated transcription*"/> <bbox w="70.0" h="25.0" x="14120.0" y="4622.75"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s520_wca1_wca3_sa377" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re131(MAP:survival): Mi-2/NuRD PMID:22290435 s_wca4_re4(MAP:survival): PMID:22699938 E2F1 PMID:15766563 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="AXIN2"/> <bbox w="70.0" h="25.0" x="13160.0" y="5041.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s534_wca1_wca3_sa382" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re133(MAP:survival): MTA1 HDAC2 were shown together with NuRD to bind to six3-promoter region. PMID:20682799 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: SIX homeobox 3 "holoprosencephaly 2 alobar or semilobar" HPE2 "sine oculis homeobox homolog 3 (Drosophila)" HUGO:SIX3 HGNC:10889 ENTREZ:6496 UNIPROT:O95343 GENECARDS:SIX3 KEGG:6496 ATLASONC:GC_SIX3 WIKI:SIX3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="SIX3"/> <bbox w="70.0" h="25.0" x="13402.0" y="5272.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s615_wca1_wca3_sa438" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re154(MAP:survival): SOX9 PMID:23306204 p300 transcription complex PMID:15806138 WNT-target gene: PMID:20122174 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TCF4"/> <bbox w="70.0" h="25.0" x="14010.0" y="5201.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s618_wca1_wca3_sa441" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re155(MAP:survival): Transcription complex containing b-catenin and P300 PMID:17050667 PMID:21767405 RAD6B is overexpressed in breast cancer PMID:11929833 RAD6B upregulated in invasive breast cancer PMID:22705350 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquitin-conjugating enzyme E2B "ubiquitin-conjugating enzyme E2B (RAD6 homolog)" HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RAD6B*"/> <bbox w="70.0" h="25.0" x="14010.0" y="5243.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s630_wca1_wca3_sa444" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re157(MAP:survival): BCL9 is a target gene of the wnt pathway. PMID:18627596 However not known which transcription complex is involved either with CBP or P300. I have chosen this complex randomly References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: B-cell CLL/lymphoma 9 HUGO:BCL9 HGNC:1008 ENTREZ:607 UNIPROT:O00512 GENECARDS:BCL9 KEGG:607 ATLASONC:BCL9ID466 WIKI:BCL9 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BCL9"/> <bbox w="70.0" h="25.0" x="14249.0" y="5158.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s644_wca1_wca3_sa446" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re159(MAP:survival): LEF1 has been identified to be involved in transcription of the MIR371-373 cluster. Only unknown if either P300 or CTBP is involved. PMID:22020335 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 372 MIRN372 HUGO:MIR372 HGNC:31786 ENTREZ:442917 GENECARDS:MIR372 KEGG:442917 ATLASONC:GC_MIR372 WIKI:MIR372 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR372"/> <bbox w="70.0" h="25.0" x="13160.0" y="5079.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s645_wca1_wca3_sa447" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re160(MAP:survival): LEF1 has been identified to be involved in transcription of the MIR371-373 cluster. Only unknown if either P300 or CTBP is involved. PMID:22020335 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 373 MIRN373 HUGO:MIR373 HGNC:31787 ENTREZ:442918 GENECARDS:MIR373 KEGG:442918 ATLASONC:GC_MIR373 WIKI:MIR373 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR373"/> <bbox w="70.0" h="25.0" x="13160.0" y="5116.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s659_wca1_wca3_sa454" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re163(MAP:survival): Though not known if this transcription is mediated by CBP in the transcripoition complex could be otherwise P300 PMID:23296977 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: insulin receptor substrate 2 HUGO:IRS2 HGNC:6126 ENTREZ:8660 UNIPROT:Q9Y4H2 GENECARDS:IRS2 REACTOME:57529 KEGG:8660 ATLASONC:GC_IRS2 WIKI:IRS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="IRS2"/> <bbox w="70.0" h="25.0" x="14249.0" y="5203.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s663_wca1_wca3_sa458" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re166(MAP:survival): Not known if P300 transcription complex mediates this trancription either it is CBP transcription complex PMID:17291450 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: teratocarcinoma-derived growth factor 1 HUGO:TDGF1 HGNC:11701 ENTREZ:6997 UNIPROT:P13385 GENECARDS:TDGF1 REACTOME:52798 KEGG:6997 ATLASONC:GC_TDGF1 WIKI:TDGF1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CRIPTO-1*"/> <bbox w="70.0" h="25.0" x="14249.0" y="5245.5"/> </glyph> <glyph class="phenotype" id="wca1_s_wca3_s271_wca1_wca3_sa215" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <label text="NF-κB pathway"/> <bbox w="80.0" h="30.0" x="14511.0" y="3467.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca3_s309_wca1_wca3_sa237" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18474248 s_wca3_re81:(MAP:survival) PMID:18744248 References_end</body> </html> </notes> <label text="DNA replication"/> <bbox w="80.0" h="30.0" x="13337.75" y="3695.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca3_s310_wca1_wca3_sa238" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re82(MAP:survival): High-cell density has positive influence on phosphorylation of APC by PKA thereby blocking nuclear import. PMID:11689703 References_end</body> </html> </notes> <label text="High cell density"/> <bbox w="80.0" h="30.0" x="13043.0" y="4016.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca3_s348_wca1_wca3_sa267" compartmentRef="wca1_wca3_c3_wca1_wca3_ca3"> <label text="Immune system"/> <bbox w="80.0" h="30.0" x="13531.0" y="3283.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca3_s477_wca1_wca3_sa357" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <label text="Differentiation"/> <bbox w="80.0" h="30.0" x="14481.0" y="4554.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca3_s558_wca1_wca3_sa399" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <label text="p53 pathway"/> <bbox w="80.0" h="30.0" x="13635.0" y="4160.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca3_s572_wca1_wca3_sa404" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re10:(MAP:survival) PMID:15526030 References_end</body> </html> </notes> <label text="Apoptosis"/> <bbox w="80.0" h="30.0" x="13685.0" y="4101.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca3_s583_wca1_wca3_sa417" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re148(MAP:survival): HIPK2 represses transcription of Vim and thus EMT PMID:22236966 References_end</body> </html> </notes> <label text="Metastasis"/> <bbox w="80.0" h="30.0" x="13581.0" y="3707.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca3_s282_wca1_wca3_sa221" compartmentRef="wca1_wca3_c3_wca1_wca3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re74:(MAP:survival) PMID:20508033 References_end</body> </html> </notes> <label text="Sonic hedgehog pathway"/> <bbox w="80.0" h="30.0" x="13824.0" y="3262.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca3_s349_wca1_wca3_sa268" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <label text="Degradation complex WNT canoncical pathway"/> <bbox w="80.0" h="30.0" x="13045.0" y="4137.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca3_s499_wca1_wca3_sa369" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <label text="Chromatin remodeling"/> <bbox w="80.0" h="30.0" x="14487.0" y="5231.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca3_s662_wca1_wca3_sa457" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <label text="PI3K AKT MTOR pathway"/> <bbox w="80.0" h="30.0" x="14396.0" y="5492.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca3_s213_wca1_wca3_sa167" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re40(MAP:survival): Not sure if ubiquitination by XIAP is necessary for replacement of TLE by b-catenin upon canonical WNT signaling PMID:22304967 s_wca3_re168(MAP:survival): contains NLS import higher when stimulated with wnt3 PMID:15720724 s_wca3_re169(MAP:survival): Upon WNT3a stimulation formation complex DVL with c-jun PMID:18347071 References_end</body> </html> </notes> <label text="Wnt canonical signaling"/> <bbox w="80.0" h="30.0" x="14302.0" y="4217.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca3_s260_wca1_wca3_sa207" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re143:(MAP:survival) PMID:15082531 References_end</body> </html> </notes> <label text="TGF-β pathway"/> <bbox w="80.0" h="30.0" x="14605.0" y="4015.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca3_s624_wca1_wca3_sa437" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Cell cycle or growth effect stimulate complex formation PMID:11972058 s_wca3_re76(MAP:survival): Complex formation of APC and CK2 is cell-cycle dependent References_end</body> </html> </notes> <label text="Cell cycle pathway"/> <bbox w="80.0" h="30.0" x="15170.0" y="4988.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca3_s143_wca1_wca3_sa111" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re19:(MAP:survival) PMID:16491118 s_wca3_re38:(MAP:survival) PMID:18519670 References_end</body> </html> </notes> <label text="CpG hyper-methylation"/> <bbox w="80.0" h="30.0" x="13297.0" y="5263.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca3_s342_wca1_wca3_sa261" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re95:(MAP:survival) PMID:22787431 References_end</body> </html> </notes> <label text="BER DNA Repair"/> <bbox w="80.0" h="30.0" x="13533.0" y="3632.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca3_s479_wca1_wca3_sa360" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <label text="Stem cell/progenitor cell maintenance and proliferation"/> <bbox w="80.0" h="30.0" x="14482.0" y="4620.25"/> </glyph> <glyph class="phenotype" id="wca1_s_wca3_s198_wca1_wca3_sa158" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <label text="Notch pathway"/> <bbox w="80.0" h="30.0" x="14602.0" y="3903.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca3_s625_wca1_wca3_sa443" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <label text="G2_M phase"/> <bbox w="80.0" h="30.0" x="15155.0" y="4903.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s1_wca1_wca3_sa1" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re2:(MAP:survival) PMID:18936100 s_wnc1_re91(MAP:survival): PMID:19701191 Dac1 primarly functions in beta-catenin-independent MODULEs PMID:21718540 s_wnc1_re93:(MAP:survival) PMID:21262972 s_wnc1_re95:(MAP:survival) PMID:16446366 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dapper antagonist of beta-catenin homolog 1 (Xenopus laevis) "dapper homolog 1 antagonist of beta-catenin (xenopus)" HUGO:DACT1 HGNC:17748 ENTREZ:51339 UNIPROT:Q9NYF0 GENECARDS:DACT1 KEGG:51339 ATLASONC:GC_DACT1 WIKI:DACT1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: dapper antagonist of beta-catenin homolog 1 (Xenopus laevis) "dapper homolog 1 antagonist of beta-catenin (xenopus)" HUGO:DACT1 HGNC:17748 ENTREZ:51339 UNIPROT:Q9NYF0 GENECARDS:DACT1 KEGG:51339 ATLASONC:GC_DACT1 WIKI:DACT1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="DACT1"/> <bbox w="80.0" h="40.0" x="13624.5" y="3517.0"/> <glyph class="state variable" id="_62a83993-4078-401e-afae-df80059a99a5"> <state value="" variable="S237"/> <bbox w="30.0" h="10.0" x="13609.992" y="3512.0"/> </glyph> <glyph class="state variable" id="_663668af-2019-4da0-ae98-e6257a82b613"> <state value="" variable="S827"/> <bbox w="30.0" h="10.0" x="13688.882" y="3552.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s2_wca1_wca3_sa2" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re1:(MAP:survival) PMID:18936100 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dapper antagonist of beta-catenin homolog 1 (Xenopus laevis) "dapper homolog 1 antagonist of beta-catenin (xenopus)" HUGO:DACT1 HGNC:17748 ENTREZ:51339 UNIPROT:Q9NYF0 GENECARDS:DACT1 KEGG:51339 ATLASONC:GC_DACT1 WIKI:DACT1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: dapper antagonist of beta-catenin homolog 1 (Xenopus laevis) "dapper homolog 1 antagonist of beta-catenin (xenopus)" HUGO:DACT1 HGNC:17748 ENTREZ:51339 UNIPROT:Q9NYF0 GENECARDS:DACT1 KEGG:51339 ATLASONC:GC_DACT1 WIKI:DACT1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="DACT1"/> <bbox w="80.0" h="40.0" x="13624.5" y="3656.0"/> <glyph class="state variable" id="_c3769491-7719-46ff-b002-8bcbdf48460e"> <state value="" variable="S237"/> <bbox w="30.0" h="10.0" x="13609.992" y="3651.0"/> </glyph> <glyph class="state variable" id="_56308667-e75e-4869-af98-3923dcf6e7f2"> <state value="" variable="S827"/> <bbox w="30.0" h="10.0" x="13688.882" y="3691.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s3_wca1_wca3_sa3" compartmentRef="wca1_wca3_c3_wca1_wca3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re2:(MAP:survival) PMID:18936100 s_wca3_re3(MAP:survival): Upon wnt signalling beta-catenin is not degraded and can enter the nucleus BCL9 and PYGO stimulate translocation of b-catenin. PMID:15208637 No active transport of b-catenin localisation of b-catenin by retention of the binding partners PMID:16554443 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 1 INT1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="WNT1"/> <bbox w="80.0" h="40.0" x="13718.0" y="3258.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s4_wca1_wca3_sa4" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="13826.75" y="3471.0"/> <glyph class="state variable" id="_3ec30ff5-32e9-430e-a042-3a6303a74975"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="13854.154" y="3506.0"/> </glyph> <glyph class="state variable" id="_6a8baf46-90a5-4229-89cd-1a9c64551d82"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="13893.632" y="3506.0"/> </glyph> <glyph class="state variable" id="_1aee3de0-fc4d-4f1d-8a25-9916fa2f58ad"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="13894.25" y="3466.2148"/> </glyph> <glyph class="state variable" id="_29e1cffb-f16b-4936-9669-f2b73914302c"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="13854.282" y="3466.0"/> </glyph> <glyph class="state variable" id="_fc888c03-f858-452e-880a-19e324d70ed9"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="13814.742" y="3466.0"/> </glyph> <glyph class="state variable" id="_5711bbb8-05ac-4c9c-829b-80e5c4160f2a"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="13814.25" y="3505.7224"/> </glyph> <glyph class="state variable" id="_d7558261-077a-4769-824a-42dbd5cec138"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="13891.75" y="3466.2148"/> </glyph> <glyph class="state variable" id="_301fbd84-71ed-4b31-bd92-1c80f53dc28d"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="13891.75" y="3466.2148"/> </glyph> <glyph class="state variable" id="_9c657c20-7587-4b00-8e1e-9b0d0e4d4b14"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13821.75" y="3486.0"/> </glyph> <glyph class="state variable" id="_1280bad6-1e55-43d3-a771-f9b01ec6b753"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="13812.242" y="3466.0"/> </glyph> <glyph class="state variable" id="_6774184d-9f97-4bfb-a8c0-a7341730ec4d"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="13891.75" y="3466.2148"/> </glyph> <glyph class="state variable" id="_947bf054-d7fb-4d43-a335-f10744941d8d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13821.75" y="3477.7158"/> </glyph> <glyph class="state variable" id="_7cad2b75-e25f-47d6-b73f-b78c59ab6046"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="13891.75" y="3466.2148"/> </glyph> <glyph class="state variable" id="_5447be8f-edab-4769-b12a-4a2aecd50ad9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13821.75" y="3486.0"/> </glyph> <glyph class="state variable" id="_1d0d4fc4-ed9c-4fcd-b43d-2cb3cef0ec98"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="13891.132" y="3506.0"/> </glyph> <glyph class="state variable" id="_48ef56c6-aeff-40a4-ba85-a6451c3ec73a"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="13891.75" y="3466.2148"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s5_wca1_wca3_sa5" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="13971.5" y="3657.0"/> <glyph class="state variable" id="_7cc14cde-c8e5-4b45-b386-be2a7edb8e98"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="13998.904" y="3692.0"/> </glyph> <glyph class="state variable" id="_c038f235-f832-4698-8a5f-5ac495c641aa"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="14038.382" y="3692.0"/> </glyph> <glyph class="state variable" id="_f9e9ea58-2c84-42f3-a065-3b5e71a9758b"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="14039.0" y="3652.2148"/> </glyph> <glyph class="state variable" id="_0807ad3c-4b2a-4d8c-95e3-7d1bbfb44c0c"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="13999.032" y="3652.0"/> </glyph> <glyph class="state variable" id="_c0688df6-45b6-4574-9d91-fdfe896b38a6"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="13959.492" y="3652.0"/> </glyph> <glyph class="state variable" id="_9df993fa-0292-4882-9f6a-687b6a5dc7d0"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="13959.0" y="3691.7224"/> </glyph> <glyph class="state variable" id="_a8b097c6-7679-4282-9727-5a7a27896a41"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="14036.5" y="3652.2148"/> </glyph> <glyph class="state variable" id="_f64887be-5e32-4904-9aa7-fb8429b9c5b4"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="14036.5" y="3652.2148"/> </glyph> <glyph class="state variable" id="_49b4bd1d-1cfe-4b16-992b-71180ddf97e0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13966.5" y="3672.0"/> </glyph> <glyph class="state variable" id="_ad2adb5c-503a-4d9f-b2c1-55ddca157392"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="13956.992" y="3652.0"/> </glyph> <glyph class="state variable" id="_52621935-98e0-4003-b818-122e80d6a0c5"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="14036.5" y="3652.2148"/> </glyph> <glyph class="state variable" id="_f8584108-877a-491f-85a0-85289fed7d39"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13966.5" y="3663.7158"/> </glyph> <glyph class="state variable" id="_cb21c0b1-ae52-4bf2-b6b9-c4cabf740159"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="14036.5" y="3652.2148"/> </glyph> <glyph class="state variable" id="_1c4d22b3-38f1-46dc-81c5-b04eaac26fb5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13966.5" y="3672.0"/> </glyph> <glyph class="state variable" id="_9b65ada4-a97c-4498-a37a-ef81276cc7b1"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="14035.882" y="3692.0"/> </glyph> <glyph class="state variable" id="_7055f835-11fd-4257-819b-f5c6a35c27f4"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="14036.5" y="3652.2148"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s12_wca1_wca3_sa11" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re3(MAP:survival): Upon wnt signalling beta-catenin is not degraded and can enter the nucleus BCL9 and PYGO stimulate translocation of b-catenin. PMID:15208637 No active transport of b-catenin localisation of b-catenin by retention of the binding partners PMID:16554443 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: pygopus homolog 1 (Drosophila) HUGO:PYGO1 HGNC:30256 ENTREZ:26108 UNIPROT:Q9Y3Y4 GENECARDS:PYGO1 WIKI:PYGO1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PYGO*"/> <bbox w="80.0" h="40.0" x="13847.0" y="3812.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s13_wca1_wca3_sa12" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re4:(MAP:survival) PMID:15208637 s_wca3_re3(MAP:survival): Upon wnt signalling beta-catenin is not degraded and can enter the nucleus BCL9 and PYGO stimulate translocation of b-catenin. PMID:15208637 No active transport of b-catenin localisation of b-catenin by retention of the binding partners PMID:16554443 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: B-cell CLL/lymphoma 9 HUGO:BCL9 HGNC:1008 ENTREZ:607 UNIPROT:O00512 GENECARDS:BCL9 KEGG:607 ATLASONC:BCL9ID466 WIKI:BCL9 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BCL9"/> <bbox w="80.0" h="40.0" x="13716.0" y="3650.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s14_wca1_wca3_sa13" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re4:(MAP:survival) PMID:15208637 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: B-cell CLL/lymphoma 9 HUGO:BCL9 HGNC:1008 ENTREZ:607 UNIPROT:O00512 GENECARDS:BCL9 KEGG:607 ATLASONC:BCL9ID466 WIKI:BCL9 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BCL9"/> <bbox w="80.0" h="40.0" x="13716.0" y="3518.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s73_wca1_wca3_sa65" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end</body> </html> Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end</body> </html> </notes> <label text="CBP*"/> <bbox w="80.0" h="40.0" x="15009.0" y="3656.0"/> <glyph class="state variable" id="_df4336c4-61d3-44f0-92e9-9217c84885c4"> <state value="" variable="S92"/> <bbox w="25.0" h="10.0" x="14996.992" y="3651.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s74_wca1_wca3_sa66" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re8(MAP:survival): MEK/ERK cascade activation is the upstream signal required for phosphorylation. PMID:21751375 s_wca3_re11(MAP:survival): CBP acetylates beta-catenin PMID:11973335 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end</body> </html> </notes> <label text="CBP*"/> <bbox w="80.0" h="40.0" x="14808.5" y="3656.0"/> <glyph class="state variable" id="_b9c8f62d-25c8-4418-93c7-2a6445a95e08"> <state value="P" variable="S92"/> <bbox w="30.0" h="10.0" x="14793.992" y="3651.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s81_wca1_wca3_sa71" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re10(MAP:survival): P300 acetylates beta-catenin PMID:15060161 s_wca3_re114(MAP:survival): KLF8 recruits P300 PMID:22761862 PMID:20107328 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: E1A binding protein p300 HUGO:EP300 HGNC:3373 ENTREZ:2033 UNIPROT:Q09472 GENECARDS:EP300 REACTOME:61164 KEGG:2033 ATLASONC:P300ID97 WIKI:EP300 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:HIF1 MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="p300*"/> <bbox w="80.0" h="40.0" x="13452.8125" y="3689.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s104_wca1_wca3_sa94" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re127:(MAP:survival) PMID:19901072 PMID:19751731 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Kruppel-like factor 4 (gut) HUGO:KLF4 HGNC:6348 ENTREZ:9314 UNIPROT:O43474 GENECARDS:KLF4 REACTOME:58119 KEGG:9314 ATLASONC:KLF4ID44316ch9q31 WIKI:KLF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="KLF4"/> <bbox w="80.0" h="40.0" x="13946.214" y="3757.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s114_wca1_wca3_sa101" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re15(MAP:survival): Acetylation of beta-catenin increases its stability PMID:18987336 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="14131.875" y="3656.0"/> <glyph class="state variable" id="_1193174a-39db-454d-88d5-bb739b853613"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="14159.279" y="3691.0"/> </glyph> <glyph class="state variable" id="_b00289ff-f48c-4669-bcb5-516ddbe8d1fb"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="14198.757" y="3691.0"/> </glyph> <glyph class="state variable" id="_0e5c43f8-c03a-4d72-bb0e-9a39b4ec9d81"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="14199.375" y="3651.2148"/> </glyph> <glyph class="state variable" id="_86beea93-6fc9-4fea-8bac-71b5f3d8f3a0"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="14159.407" y="3651.0"/> </glyph> <glyph class="state variable" id="_903fc85d-1e17-4153-aded-fc7485cef055"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="14119.867" y="3651.0"/> </glyph> <glyph class="state variable" id="_302d0ec6-87f0-4977-ba80-311452eed2d0"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="14119.375" y="3690.7224"/> </glyph> <glyph class="state variable" id="_09e3252f-9777-4948-ae89-6cf5ddb7f006"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="14196.875" y="3651.2148"/> </glyph> <glyph class="state variable" id="_5a8c13d7-347f-4867-9684-458b00dfaa42"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="14196.875" y="3651.2148"/> </glyph> <glyph class="state variable" id="_39241504-ec91-457a-b365-e4710313f072"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14126.875" y="3671.0"/> </glyph> <glyph class="state variable" id="_58371ea6-eaba-4845-bf7a-26a73df7168d"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="14117.367" y="3651.0"/> </glyph> <glyph class="state variable" id="_8971bf3d-b181-4407-8f11-4cd66ae8bd17"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="14196.875" y="3651.2148"/> </glyph> <glyph class="state variable" id="_81a04416-8ad6-41bc-a6db-ead6c0b45f0b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14126.875" y="3662.7158"/> </glyph> <glyph class="state variable" id="_fcce822b-f092-4406-8e51-2dfdb8964ee4"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="14196.875" y="3651.2148"/> </glyph> <glyph class="state variable" id="_c74f8115-f73b-435a-85b3-313135cb4099"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14126.875" y="3671.0"/> </glyph> <glyph class="state variable" id="_8c7f0a8c-7aba-4a83-aa57-f784684d6a5c"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="14196.257" y="3691.0"/> </glyph> <glyph class="state variable" id="_bca4b98e-7afc-47e6-9f73-fbc01ed3128f"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="14196.875" y="3651.2148"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s116_wca1_wca3_sa103" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re15(MAP:survival): Acetylation of beta-catenin increases its stability PMID:18987336 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: K(lysine) acetyltransferase 2B "p300/CBP-associated factor" PCAF HUGO:KAT2B HGNC:8638 ENTREZ:8850 UNIPROT:Q92831 GENECARDS:KAT2B REACTOME:61366 KEGG:8850 ATLASONC:GC_KAT2B WIKI:KAT2B Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="PCAF*"/> <bbox w="80.0" h="40.0" x="14051.0" y="3722.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s136_wca1_wca3_sa104" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re18(MAP:survival): The exact mechanism is depicted in the cytoplasmic fraction. Although the articles do not mention where exactly the reactions occurs TNKS are found in the cytoplasm and in the nucleus. PMID:17825467 PMID:19759537 PMID:21799911 s_wnc4_re8:(MAP:survival) PMID:15526030 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="14337.0" y="4772.0"/> <glyph class="state variable" id="_e7665d4e-3003-480a-9192-3428865ea176"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="14324.992" y="4767.0"/> </glyph> <glyph class="state variable" id="_99963bda-6fad-4f9c-8198-e95bcb7a1fab"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="14364.532" y="4767.0"/> </glyph> <glyph class="state variable" id="_41295b5f-dcab-409b-a0fa-b23da5b40398"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="14402.0" y="4767.215"/> </glyph> <glyph class="state variable" id="_9e998f7c-708d-4fd3-97a0-6b5d990ea949"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="14401.382" y="4807.0"/> </glyph> <glyph class="state variable" id="_601c2423-ab8f-4a48-af5a-1308cee70c26"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="14361.904" y="4807.0"/> </glyph> <glyph class="state variable" id="_4e9664cc-9217-421b-a4f6-db54c6e32538"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="14322.0" y="4806.722"/> </glyph> <glyph class="state variable" id="_41718018-2aed-4a31-8711-af4419b821e6"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="14364.404" y="4807.0"/> </glyph> <glyph class="state variable" id="_834cd3fd-861d-432e-a314-4f76ba5e5a5b"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="14403.882" y="4807.0"/> </glyph> <glyph class="state variable" id="_c7aea659-9b59-43aa-9939-880a0c07d341"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14409.5" y="4767.215"/> </glyph> <glyph class="state variable" id="_9526e637-ca0a-4fa8-819c-a2954b821c16"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="14324.5" y="4806.722"/> </glyph> <glyph class="state variable" id="_e21faecf-d28a-4236-beca-c4fdce40e950"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14329.992" y="4767.0"/> </glyph> <glyph class="state variable" id="_48f5bfca-93b0-4d3a-89d8-de172183af02"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14332.0" y="4767.0"/> </glyph> <glyph class="state variable" id="_ec109471-e6fa-46f1-9da4-f7f313d4954a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14412.0" y="4767.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s137_wca1_wca3_sa105" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re18(MAP:survival): The exact mechanism is depicted in the cytoplasmic fraction. Although the articles do not mention where exactly the reactions occurs TNKS are found in the cytoplasm and in the nucleus. PMID:17825467 PMID:19759537 PMID:21799911 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <label text="AXIN*"/> <bbox w="80.0" h="40.0" x="14525.5" y="4768.0"/> <glyph class="state variable" id="_da8ff94d-6f09-4f7e-8129-ceeceed53153"> <state value="" variable="S80"/> <bbox w="25.0" h="10.0" x="14513.492" y="4763.0"/> </glyph> <glyph class="state variable" id="_d728b810-52a0-4ae1-854f-5a5cb0c67c8e"> <state value="" variable="S82"/> <bbox w="25.0" h="10.0" x="14553.032" y="4763.0"/> </glyph> <glyph class="state variable" id="_122881a8-12b3-41c7-824b-6032e243ed3c"> <state value="" variable="S222"/> <bbox w="30.0" h="10.0" x="14590.5" y="4763.215"/> </glyph> <glyph class="state variable" id="_b67e75df-d18e-46d4-aff3-4cb54728974b"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="14589.882" y="4803.0"/> </glyph> <glyph class="state variable" id="_3e15f1fe-6d12-4b7e-8b19-5787df28f66c"> <state value="" variable="S614"/> <bbox w="30.0" h="10.0" x="14550.404" y="4803.0"/> </glyph> <glyph class="state variable" id="_086a026d-b422-4e84-b9c1-b2a2be000a9e"> <state value="" variable="S621"/> <bbox w="30.0" h="10.0" x="14510.5" y="4802.722"/> </glyph> <glyph class="state variable" id="_159b43aa-e43b-4b36-9a4a-5bf6d5f8c228"> <state value="" variable="K48"/> <bbox w="25.0" h="10.0" x="14552.904" y="4803.0"/> </glyph> <glyph class="state variable" id="_5ff8e868-4613-443b-92cb-e3c6de8c6b24"> <state value="" variable="K11"/> <bbox w="25.0" h="10.0" x="14592.382" y="4803.0"/> </glyph> <glyph class="state variable" id="_a2121063-9f0b-4eea-8431-abb01866df23"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14598.0" y="4763.215"/> </glyph> <glyph class="state variable" id="_bbf9ec44-cd9e-4ca3-aed1-76ef93abbd4b"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="14513.0" y="4802.722"/> </glyph> <glyph class="state variable" id="_0b75d2b1-a247-4624-9787-ba170e8cb67d"> <state value="" variable="E"/> <bbox w="15.0" h="10.0" x="14518.492" y="4763.0"/> </glyph> <glyph class="state variable" id="_ddc468c0-5c1c-42e8-bc73-a645d1e9f788"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="14515.5" y="4763.0"/> </glyph> <glyph class="state variable" id="_00799a5a-aa88-4924-b99a-0800d0d3e6c3"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="14595.5" y="4763.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s138_wca1_wca3_sa106" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:21383061 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquitin specific peptidase 34 "ubiquitin specific protease 34" HUGO:USP34 HGNC:20066 ENTREZ:9736 UNIPROT:Q70CQ2 GENECARDS:USP34 WIKI:USP34 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="USP34"/> <bbox w="80.0" h="40.0" x="14430.0" y="4881.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s139_wca1_wca3_sa107" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re18(MAP:survival): The exact mechanism is depicted in the cytoplasmic fraction. Although the articles do not mention where exactly the reactions occurs TNKS are found in the cytoplasm and in the nucleus. PMID:17825467 PMID:19759537 PMID:21799911 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tankyrase TRF1-interacting ankyrin-related ADP-ribose polymerase HUGO:TNKS HGNC:11941 ENTREZ:8658 UNIPROT:O95271 GENECARDS:TNKS KEGG:8658 ATLASONC:TNKSID43534ch8p23 WIKI:TNKS tankyrase TRF1-interacting ankyrin-related ADP-ribose polymerase 2 HUGO:TNKS2 HGNC:15677 ENTREZ:80351 UNIPROT:Q9H2K2 GENECARDS:TNKS2 KEGG:80351 ATLASONC:GC_TNKS2 WIKI:TNKS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TNKS1_2*"/> <bbox w="80.0" h="40.0" x="14361.0" y="4698.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s140_wca1_wca3_sa108" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re18(MAP:survival): The exact mechanism is depicted in the cytoplasmic fraction. Although the articles do not mention where exactly the reactions occurs TNKS are found in the cytoplasm and in the nucleus. PMID:17825467 PMID:19759537 PMID:21799911 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ring finger protein 146 HUGO:RNF146 HGNC:21336 ENTREZ:81847 UNIPROT:Q9NTX7 GENECARDS:RNF146 KEGG:81847 ATLASONC:GC_RNF146 WIKI:RNF146 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22274711 References_end</body> </html> </notes> <label text="RNF146"/> <bbox w="80.0" h="40.0" x="14486.0" y="4698.0"/> <glyph class="state variable" id="_3b6c1332-2ffc-48c1-90ca-729c3af28755"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14561.0" y="4733.0"/> </glyph> <glyph class="state variable" id="_404d93c4-c223-4a71-8073-6e6b0ba1beba"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14561.0" y="4693.0"/> </glyph> <glyph class="state variable" id="_4813a459-b616-49aa-a250-b7b33c6459e3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14481.0" y="4733.0"/> </glyph> <glyph class="state variable" id="_309e6b69-3446-4ef9-8b24-0c35eb4f6b35"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14481.0" y="4693.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s145_wca1_wca3_sa112" compartmentRef="wca1_wca3_c3_wca1_wca3_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: wingless-type MMTV integration site family member 1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 wingless-type MMTV integration site family member 3 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="WNT1_3*"/> <bbox w="50.0" h="25.0" x="13130.0" y="3278.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s146_wca1_wca3_sa113" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc1_re62(MAP:survival): Cthrc1 enhances formation of Wnt-Fzl-Ror2 complex PMID:12839624 PMID:18606138 Syndecan-4 binds to Fzl, Dvl and is required for PCP MODULE. PMID:16604063 PMID:21397842 Vangl-2 forms complex upon binding with Wnt-5 PMID:21316585 ROR2 is associated with Wnt, Fzl and CK1_epsilon PMID:20215527 PPR binds to Fzl in both canonical and non-canonical MODULE PMID:20093472 PMID:21380625 PMID:20579883 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: receptor tyrosine kinase-like orphan receptor 2 BDB BDB1 NTRKR2 HUGO:ROR2 HGNC:10257 ENTREZ:4920 UNIPROT:Q01974 GENECARDS:ROR2 KEGG:6095 ATLASONC:ROR2ID43476ch9q22 WIKI:ROR2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="ROR2"/> <bbox w="80.0" h="50.0" x="13208.0" y="3319.0"/> <glyph class="state variable" id="_2ef852e2-0015-49ce-89fb-9d11793691d0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13243.0" y="3364.0"/> </glyph> <glyph class="state variable" id="_7352a602-90f6-49d7-acfa-4a4284e27f39"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13203.0" y="3314.0"/> </glyph> <glyph class="state variable" id="_a77a510d-9bbe-4052-85b6-c73cbd3c2efd"> <state value="" variable="S864"/> <bbox w="30.0" h="10.0" x="13273.0" y="3314.2686"/> </glyph> <glyph class="state variable" id="_2ea98cfe-39fd-4aaa-9f24-6ffef9c170c5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13283.0" y="3364.0"/> </glyph> <glyph class="unit of information" id="_e04bcba0-0446-48c6-95f9-d96a97ac9e90"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="13225.5" y="3314.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s147_wca1_wca3_sa114" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end Identifiers_begin: frizzled family receptor 1 HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 frizzled family receptor 2 HUGO:FZD2 HGNC:4040 ENTREZ:2535 UNIPROT:Q14332 GENECARDS:FZD2 REACTOME:55168 KEGG:2535 ATLASONC:GC_FZD2 WIKI:FZD2 frizzled family receptor 3 HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 frizzled family receptor 4 HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 frizzled family receptor 5 HUGO:FZD5 HGNC:4043 ENTREZ:7855 UNIPROT:Q13467 GENECARDS:FZD5 REACTOME:55174 KEGG:7855 ATLASONC:GC_FZD5 WIKI:FZD5 frizzled family receptor 6 HUGO:FZD6 HGNC:4044 ENTREZ:8323 UNIPROT:O60353 GENECARDS:FZD6 REACTOME:55176 KEGG:8323 ATLASONC:GC_FZD6 WIKI:FZD6 frizzled family receptor 7 HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 frizzled family receptor 9 HUGO:FZD9 HGNC:4047 ENTREZ:8326 UNIPROT:O00144 GENECARDS:FZD9 REACTOME:55182 KEGG:8326 ATLASONC:GC_FZD9 WIKI:FZD9 frizzled family receptor 10 HUGOFZD10 HGNC:4039 ENTREZ:11211 UNIPROT:Q9ULW2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17884187 Activators: Fz1 Fz4 PMID:19020754 PMID:14704854 PMID:17127310 References_end</body> </html> </notes> <label text="FZD*"/> <bbox w="80.0" h="50.0" x="13110.0" y="3319.0"/> <glyph class="unit of information" id="_da2c4777-3822-4fb6-b97e-d4b43bd19598"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="13127.5" y="3314.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s153_wca1_wca3_sa135" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> Identifiers_begin: mitogen-activated protein kinase kinase kinase 7 TAK1 HUGO:MAP3K7 HGNC:6859 ENTREZ:6885 UNIPROT:O43318 GENECARDS:MAP3K7 REACTOME:168070 KEGG:6885 ATLASONC:MAP3K7ID454ch6q15 WIKI:MAP3K7 MEKK7 MEKK7 TAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. PMID:18855897 PMID:11274345 References_end</body> </html> </notes> <label text="TAK1*"/> <bbox w="80.0" h="40.0" x="13536.0" y="3375.5"/> <glyph class="state variable" id="_934dfa0f-93f6-466c-b79b-bbeb2883288d"> <state value="" variable="T187"/> <bbox w="30.0" h="10.0" x="13521.492" y="3370.5"/> </glyph> <glyph class="state variable" id="_c5b0d286-1ffa-4f01-98cf-3dc34441c5c0"> <state value="" variable="S192"/> <bbox w="30.0" h="10.0" x="13600.382" y="3410.5"/> </glyph> <glyph class="state variable" id="_534c32d0-1c6c-4a63-879b-2e4a2938920a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13531.0" y="3390.5"/> </glyph> <glyph class="state variable" id="_37ca3233-a8cf-4d55-baa1-557e67f10662"> <state value="" variable="T184"/> <bbox w="30.0" h="10.0" x="13521.492" y="3370.5"/> </glyph> <glyph class="state variable" id="_fef16009-9da1-489a-80d4-9e603537ae02"> <state value="" variable="T178"/> <bbox w="30.0" h="10.0" x="13521.0" y="3410.2224"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s160_wca1_wca3_sa152" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: TCF family: tcf-1 lef-1 tcf-3 tcf-4 PMID:11266540 TCF3 is repressor while others are activators of transcription PMID:21285352 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 transcription factor 7-like 1 (T-cell specific HMG-box) TCF3 HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 transcription factor 7-like 2 (T-cell specific HMG-box) TCF4 HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end</body> </html> </notes> <label text="LEF_TCF*"/> <bbox w="80.0" h="40.0" x="14018.417" y="4141.5"/> <glyph class="state variable" id="_a47457a3-30cd-452e-bbd3-321aa1e841e9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14093.417" y="4137.378"/> </glyph> <glyph class="state variable" id="_92ac3b83-7fd7-4301-918f-5988407b03b3"> <state value="" variable="S40"/> <bbox w="25.0" h="10.0" x="14085.917" y="4173.1143"/> </glyph> <glyph class="state variable" id="_d2d9ce1c-e69b-44b4-85b7-1d23214e034f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14093.417" y="4156.5"/> </glyph> <glyph class="state variable" id="_c76e4d7b-b060-42cd-bcd2-d0a56c5d4317"> <state value="" variable="S166"/> <bbox w="30.0" h="10.0" x="14003.909" y="4136.5"/> </glyph> <glyph class="state variable" id="_ada237d0-7127-42be-9509-20b9dd9ad42d"> <state value="" variable="T155"/> <bbox w="30.0" h="10.0" x="14003.417" y="4176.222"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s161_wca1_wca3_sa126" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: NLK also phosphorylates TCF4@T178 and T189 PMID:12556497 s_wca3_re26:(MAP:survival) PMID:14960582 s_wca3_re32:(MAP:survival) PMID:16714285 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 transcription factor 7-like 1 (T-cell specific HMG-box) TCF3 HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 transcription factor 7-like 2 (T-cell specific HMG-box) TCF4 HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end</body> </html> </notes> <label text="LEF_TCF*"/> <bbox w="80.0" h="40.0" x="13866.0" y="4141.5"/> <glyph class="state variable" id="_7e77776a-f969-45fa-8c70-5ec27f5181aa"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13941.0" y="4137.378"/> </glyph> <glyph class="state variable" id="_87748af9-4c81-4995-a100-2adf90122c87"> <state value="" variable="S40"/> <bbox w="25.0" h="10.0" x="13933.5" y="4173.1143"/> </glyph> <glyph class="state variable" id="_11b0b29a-0f0a-4bff-863f-96836c67174d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13941.0" y="4156.5"/> </glyph> <glyph class="state variable" id="_4009d61d-0a00-4a41-823d-4a1cbef59a45"> <state value="P" variable="S166"/> <bbox w="35.0" h="10.0" x="13848.992" y="4136.5"/> </glyph> <glyph class="state variable" id="_92a3e42a-8d83-4b6d-ad00-81a6403b0369"> <state value="P" variable="T155"/> <bbox w="35.0" h="10.0" x="13848.5" y="4176.222"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s162_wca1_wca3_sa128" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re27:(MAP:survival) PMID:21118996 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nemo-like kinase "nemo like kinase" HUGO:NLK HGNC:29858 ENTREZ:51701 UNIPROT:Q9UBE8 GENECARDS:NLK KEGG:2821 ATLASONC:GC_NLK WIKI:NLK Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="NLK"/> <bbox w="80.0" h="40.0" x="14013.0" y="3366.232"/> <glyph class="state variable" id="_01abaf9a-ac6c-409d-9cdc-f0b54a5b0d63"> <state value="" variable="T286"/> <bbox w="30.0" h="10.0" x="14078.0" y="3361.4468"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="wca1_s_wca3_s163_wca1_wca3_sa131" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re27:(MAP:survival) PMID:21118996 s_wca3_re28(MAP:survival): PMID:21118996 PMID:15082531 Auto-phosphorylation HIPK2 may induce autophoshorylationMaps_Modules_end References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nemo-like kinase "nemo like kinase" HUGO:NLK HGNC:29858 ENTREZ:51701 UNIPROT:Q9UBE8 GENECARDS:NLK KEGG:2821 ATLASONC:GC_NLK WIKI:NLK Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="NLK"/> <bbox w="86.0" h="46.0" x="13875.0" y="3366.232"/> <glyph class="unit of information" id="_29a3146e-3f0c-4f59-bc6c-5020ac649d93"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="13908.0" y="3361.232"/> </glyph> <glyph class="state variable" id="_554a71b1-54a6-4f4c-ac63-7478ce9a78fc"> <state value="" variable="T286"/> <bbox w="30.0" h="10.0" x="13946.0" y="3361.479"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="wca1_s_wca3_s164_wca1_wca3_sa132" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re28(MAP:survival): PMID:21118996 PMID:15082531 Auto-phosphorylation HIPK2 may induce autophoshorylationMaps_Modules_end References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nemo-like kinase "nemo like kinase" HUGO:NLK HGNC:29858 ENTREZ:51701 UNIPROT:Q9UBE8 GENECARDS:NLK KEGG:2821 ATLASONC:GC_NLK WIKI:NLK Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="NLK"/> <bbox w="86.0" h="46.0" x="13759.0" y="3366.232"/> <glyph class="unit of information" id="_da58494d-52f6-481b-b71c-07bb73ffefb8"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="13792.0" y="3361.232"/> </glyph> <glyph class="state variable" id="_6780b9ed-375c-4daf-90cf-44ce8adfc635"> <state value="P" variable="T286"/> <bbox w="35.0" h="10.0" x="13827.5" y="3361.479"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="wca1_s_wca3_s165_wca1_wca3_sa133" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re29:(MAP:survival) PMID:21118996 s_wca3_re25:(MAP:survival) PMID:20194509 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nemo-like kinase "nemo like kinase" HUGO:NLK HGNC:29858 ENTREZ:51701 UNIPROT:Q9UBE8 GENECARDS:NLK KEGG:2821 ATLASONC:GC_NLK WIKI:NLK Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="NLK"/> <bbox w="86.0" h="46.0" x="13760.25" y="3748.2947"/> <glyph class="unit of information" id="_24baf93b-4fac-4892-8987-e20066a3c72a"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="13793.25" y="3743.2947"/> </glyph> <glyph class="state variable" id="_69c9589e-30a3-4438-98b2-996ff63d38e7"> <state value="P" variable="T286"/> <bbox w="35.0" h="10.0" x="13828.75" y="3743.5417"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s166_wca1_wca3_sa134" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re30:(MAP:survival) PMID:20538596 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 1 MAP3K7IP1 "mitogen-activated protein kinase kinase kinase 7 interacting protein 1" HUGO:TAB1 HGNC:18157 ENTREZ:10454 UNIPROT:Q15750 GENECARDS:TAB1 REACTOME:65612 KEGG:10454 ATLASONC:GC_TAB1 WIKI:TAB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 1 MAP3K7IP1 "mitogen-activated protein kinase kinase kinase 7 interacting protein 1" HUGO:TAB1 HGNC:18157 ENTREZ:10454 UNIPROT:Q15750 GENECARDS:TAB1 REACTOME:65612 KEGG:10454 ATLASONC:GC_TAB1 WIKI:TAB1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TAB1"/> <bbox w="80.0" h="40.0" x="13540.0" y="3474.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s183_wca1_wca3_sa143" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re25:(MAP:survival) PMID:20194509 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 2 MAP3K7IP2 "mitogen-activated protein kinase kinase kinase 7 interacting protein 2" HUGO:TAB2 HGNC:17075 ENTREZ:23118 UNIPROT:Q9NYJ8 GENECARDS:TAB2 REACTOME:168084 KEGG:23118 ATLASONC:GC_TAB2 WIKI:TAB2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: TGF-beta activated kinase 1/MAP3K7 binding protein 2 MAP3K7IP2 "mitogen-activated protein kinase kinase kinase 7 interacting protein 2" HUGO:TAB2 HGNC:17075 ENTREZ:23118 UNIPROT:Q9NYJ8 GENECARDS:TAB2 REACTOME:168084 KEGG:23118 ATLASONC:GC_TAB2 WIKI:TAB2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TAB2"/> <bbox w="80.0" h="40.0" x="13661.0" y="3959.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s185_wca1_wca3_sa146" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re32:(MAP:survival) PMID:16714285 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: nuclear prelamin A recognition factor HUGO:NARF HGNC:29916 ENTREZ:26502 UNIPROT:Q9UHQ1 GENECARDS:NARF KEGG:51444 WIKI:NARF Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="NARF"/> <bbox w="80.0" h="40.0" x="13706.5" y="4208.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s187_wca1_wca3_sa148" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re151:(MAP:survival) PMID:22322943 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> </notes> <label text="E1*"/> <clone/> <bbox w="80.0" h="40.0" x="13902.5" y="4208.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s187_wca1_wca3_sa434" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re151:(MAP:survival) PMID:22322943 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> </notes> <label text="E1*"/> <clone/> <bbox w="80.0" h="40.0" x="14686.0" y="5119.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s188_wca1_wca3_sa145" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re32:(MAP:survival) PMID:16714285 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 transcription factor 7-like 1 (T-cell specific HMG-box) TCF3 HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 transcription factor 7-like 2 (T-cell specific HMG-box) TCF4 HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end</body> </html> </notes> <label text="LEF_TCF*"/> <bbox w="80.0" h="40.0" x="13741.25" y="4141.5"/> <glyph class="state variable" id="_9cbd641e-7ad5-481c-84cf-c264bb8b9b31"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="13811.25" y="4137.378"/> </glyph> <glyph class="state variable" id="_44d03eeb-8896-48e5-a1d6-55d360743df7"> <state value="" variable="S40"/> <bbox w="25.0" h="10.0" x="13808.75" y="4173.1143"/> </glyph> <glyph class="state variable" id="_ce86e9ee-d909-4b9e-9cac-9ad42a93dcd9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13816.25" y="4156.5"/> </glyph> <glyph class="state variable" id="_d6deb629-f7e7-40ce-96e8-d306444d2638"> <state value="P" variable="S166"/> <bbox w="35.0" h="10.0" x="13724.242" y="4136.5"/> </glyph> <glyph class="state variable" id="_e2f2669d-f096-44b7-88dd-b7eb65d583c9"> <state value="P" variable="T155"/> <bbox w="35.0" h="10.0" x="13723.75" y="4176.222"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s190_wca1_wca3_sa150" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re35(MAP:survival): CK2 phosphorylates TLE PMID:15367661 s_wca3_re39(MAP:survival): Its suggested that XIAP constitutively ubiquitinate TLE PMID:22304967 s_wca3_re111:(MAP:survival) PMID:16510874 s_wca3_re135:(MAP:survival) PMID:12050133 PPMID:12441302 s_wca3_re138:(MAP:survival) PMID:20925119 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: transducin-like enhancer of split 1 (E(sp1) homolog Drosophila) "transducin-like enhancer of split 1 homolog of Drosophila E(sp1)" HUGO:TLE1 HGNC:11837 ENTREZ:7088 UNIPROT:Q04724 GENECARDS:TLE1 REACTOME:66083 KEGG:7088 ATLASONC:GC_TLE1 WIKI:TLE1 transducin-like enhancer of split 2 (E(sp1) homolog Drosophila) HUGO:TLE2 HGNC:11838 ENTREZ:7089 UNIPROT:Q04725 GENECARDS:TLE2 REACTOME:66085 KEGG:7089 WIKI:TLE2 transducin-like enhancer of split 3 (E(sp1) homolog Drosophila) HUGO:TLE3 HGNC:11839 ENTREZ:7090 UNIPROT:Q04726 GENECARDS:TLE3 REACTOME:405165 KEGG:7090 ATLASONC:GC_TLE3 WIKI:TLE3 transducin-like enhancer of split 4 (E(sp1) homolog Drosophila) HUGO:TLE4 HGNC:11840 ENTREZ:7091 UNIPROT:Q04727 GENECARDS:TLE4 REACTOME:66089 KEGG:7091 WIKI:TLE4 amino-terminal enhancer of split GRG5 TLE5 HUGO:AES HGNC:307 ENTREZ:166 UNIPROT:Q08117 GENECARDS:AES KEGG:166 ATLASONC:GC_AES WIKI:AES transducin-like enhancer of split 6 (E(sp1) homolog Drosophila) HUGO:TLE6 HGNC:30788 ENTREZ:79816 UNIPROT:Q9H808 GENECARDS:TLE6 KEGG:79816 ATLASONC:GC_TLE6 WIKI:TLE6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: References_begin non-DNA binding transcription factor PMID:20925119 References-end References_end</body> </html> </notes> <label text="TLE*"/> <bbox w="80.0" h="40.0" x="14203.417" y="4141.5"/> <glyph class="state variable" id="_887eebe9-c894-41fd-80c0-22da2075e87f"> <state value="" variable="S239"/> <bbox w="30.0" h="10.0" x="14188.909" y="4136.5"/> </glyph> <glyph class="state variable" id="_a162125e-d773-4a43-9b3d-8ab6b363f091"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14278.417" y="4136.5"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s191_wca1_wca3_sa151" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re106:(MAP:survival) PMID:12681518 PMID:16510874 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: histone deacetylase 1 HUGO:HDAC1 HGNC:4852 ENTREZ:3065 UNIPROT:Q13547 GENECARDS:HDAC1 REACTOME:56408 KEGG:3065 ATLASONC:GC_HDAC1 WIKI:HDAC1 HUGO:HDAC2 HGNC:4853 ENTREZ:3066 UNIPROT:Q92769 GENECARDS:HDAC2 REACTOME:56410 KEGG:3066 ATLASONC:HDAC2ID40803ch6q22 WIKI:HDAC2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HDAC1_2*"/> <bbox w="80.0" h="40.0" x="14111.406" y="4141.5"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s192_wca1_wca3_sa153" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re35(MAP:survival): CK2 phosphorylates TLE PMID:15367661 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: transducin-like enhancer of split 1 (E(sp1) homolog Drosophila) "transducin-like enhancer of split 1 homolog of Drosophila E(sp1)" HUGO:TLE1 HGNC:11837 ENTREZ:7088 UNIPROT:Q04724 GENECARDS:TLE1 REACTOME:66083 KEGG:7088 ATLASONC:GC_TLE1 WIKI:TLE1 transducin-like enhancer of split 2 (E(sp1) homolog Drosophila) HUGO:TLE2 HGNC:11838 ENTREZ:7089 UNIPROT:Q04725 GENECARDS:TLE2 REACTOME:66085 KEGG:7089 WIKI:TLE2 transducin-like enhancer of split 3 (E(sp1) homolog Drosophila) HUGO:TLE3 HGNC:11839 ENTREZ:7090 UNIPROT:Q04726 GENECARDS:TLE3 REACTOME:405165 KEGG:7090 ATLASONC:GC_TLE3 WIKI:TLE3 transducin-like enhancer of split 4 (E(sp1) homolog Drosophila) HUGO:TLE4 HGNC:11840 ENTREZ:7091 UNIPROT:Q04727 GENECARDS:TLE4 REACTOME:66089 KEGG:7091 WIKI:TLE4 amino-terminal enhancer of split GRG5 TLE5 HUGO:AES HGNC:307 ENTREZ:166 UNIPROT:Q08117 GENECARDS:AES KEGG:166 ATLASONC:GC_AES WIKI:AES transducin-like enhancer of split 6 (E(sp1) homolog Drosophila) HUGO:TLE6 HGNC:30788 ENTREZ:79816 UNIPROT:Q9H808 GENECARDS:TLE6 KEGG:79816 ATLASONC:GC_TLE6 WIKI:TLE6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: References_begin non-DNA binding transcription factor PMID:20925119 References-end References_end</body> </html> </notes> <label text="TLE*"/> <bbox w="80.0" h="40.0" x="14353.666" y="4141.222"/> <glyph class="state variable" id="_0d4d072e-eb86-4aa4-aec0-38fcb47aa4b3"> <state value="P" variable="S239"/> <bbox w="35.0" h="10.0" x="14336.658" y="4136.222"/> </glyph> <glyph class="state variable" id="_87fe3ab5-bcfe-4dbd-854e-2d0cec992270"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14428.666" y="4136.222"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s194_wca1_wca3_sa155" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re37:(MAP:survival) PMID:15367661 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: hairy and enhancer of split 1 (Drosophila) "hairy homolog (Drosophila)" HRY HUGO:HES1 HGNC:5192 ENTREZ:3280 UNIPROT:Q14469 GENECARDS:HES1 REACTOME:56466 KEGG:3280 ATLASONC:GC_HES1 WIKI:HES1 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:FANCONI MAP:dnarepair / MODULE:TLS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HES1"/> <bbox w="80.0" h="40.0" x="14360.0" y="3933.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s201_wca1_wca3_sa161" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re39(MAP:survival): Its suggested that XIAP constitutively ubiquitinate TLE PMID:22304967 s_wca3_re40(MAP:survival): Not sure if ubiquitination by XIAP is necessary for replacement of TLE by b-catenin upon canonical WNT signaling References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: X-linked inhibitor of apoptosis API3 "baculoviral IAP repeat-containing 4" BIRC4 HUGO:XIAP HGNC:592 ENTREZ:331 UNIPROT:P98170 GENECARDS:XIAP REACTOME:50850 KEGG:331 ATLASONC:GC_XIAP WIKI:XIAP Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="XIAP"/> <bbox w="80.0" h="40.0" x="14028.0" y="4224.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s202_wca1_wca3_sa166" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re39(MAP:survival): Its suggested that XIAP constitutively ubiquitinate TLE PMID:22304967 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: transducin-like enhancer of split 1 (E(sp1) homolog Drosophila) "transducin-like enhancer of split 1 homolog of Drosophila E(sp1)" HUGO:TLE1 HGNC:11837 ENTREZ:7088 UNIPROT:Q04724 GENECARDS:TLE1 REACTOME:66083 KEGG:7088 ATLASONC:GC_TLE1 WIKI:TLE1 transducin-like enhancer of split 2 (E(sp1) homolog Drosophila) HUGO:TLE2 HGNC:11838 ENTREZ:7089 UNIPROT:Q04725 GENECARDS:TLE2 REACTOME:66085 KEGG:7089 WIKI:TLE2 transducin-like enhancer of split 3 (E(sp1) homolog Drosophila) HUGO:TLE3 HGNC:11839 ENTREZ:7090 UNIPROT:Q04726 GENECARDS:TLE3 REACTOME:405165 KEGG:7090 ATLASONC:GC_TLE3 WIKI:TLE3 transducin-like enhancer of split 4 (E(sp1) homolog Drosophila) HUGO:TLE4 HGNC:11840 ENTREZ:7091 UNIPROT:Q04727 GENECARDS:TLE4 REACTOME:66089 KEGG:7091 WIKI:TLE4 amino-terminal enhancer of split GRG5 TLE5 HUGO:AES HGNC:307 ENTREZ:166 UNIPROT:Q08117 GENECARDS:AES KEGG:166 ATLASONC:GC_AES WIKI:AES transducin-like enhancer of split 6 (E(sp1) homolog Drosophila) HUGO:TLE6 HGNC:30788 ENTREZ:79816 UNIPROT:Q9H808 GENECARDS:TLE6 KEGG:79816 ATLASONC:GC_TLE6 WIKI:TLE6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: References_begin non-DNA binding transcription factor PMID:20925119 References-end References_end</body> </html> </notes> <label text="TLE*"/> <bbox w="80.0" h="40.0" x="14203.25" y="4269.0"/> <glyph class="state variable" id="_c5eb661a-4bb1-48d7-a2b2-a37de0f8da12"> <state value="" variable="S239"/> <bbox w="30.0" h="10.0" x="14188.742" y="4264.0"/> </glyph> <glyph class="state variable" id="_5fc4da7c-bb0c-4132-87bb-9c29033d32f8"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="14273.25" y="4264.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s220_wca1_wca3_sa174" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 References_end Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end</body> </html> Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end</body> </html> Identifiers_begin: tumor protein P53 HUGO:TP53 HGNC:11998 ENTREZ:7157 UNIPROT:P04637 GENECARDS:TP53 REACTOME:69487 KEGG:7157 ATLASONC:P53ID88 WIKI:TP53 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: P53 is a nuclear P38 target. PMID:20506250 PMID:10721693 PMID:19459846 References_end</body> </html> </notes> <label text="p53*"/> <bbox w="80.0" h="40.0" x="13297.0" y="4692.0"/> <glyph class="state variable" id="_3cdee49a-9cfa-4669-9745-d2b19e11327c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13372.0" y="4727.0"/> </glyph> <glyph class="state variable" id="_2d9406c6-6f07-4a47-946a-93f227f29eb6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13292.0" y="4687.0"/> </glyph> <glyph class="state variable" id="_27c2f814-ab3f-40c8-aa77-52c9dc5c5136"> <state value="" variable="S46"/> <bbox w="25.0" h="10.0" x="13364.5" y="4687.215"/> </glyph> <glyph class="state variable" id="_80859aa8-ef4a-498b-a5e1-b525fbeee5b1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13292.0" y="4707.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s247_wca1_wca3_sa195" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re64(MAP:survival): Under pathological conditions this complex will be formed. This complex has synergistic positive effect on myc gene expression. PMID:15576399 s_wca3_re65(MAP:survival): PMID:22761862 Smad1 alone inhibits myc expression while b-catenin/TCF4 activates gene expression. Highest gene expression obtained when SMAD1/b-catenin/TCF4 complex is formed Mi-2/NuRD PMID:22290435 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: SMAD family member 1 "MAD mothers against decapentaplegic homolog 1 (Drosophila)" MADH1 "SMAD mothers against DPP homolog 1 (Drosophila)" HUGO:SMAD1 HGNC:6767 ENTREZ:4086 UNIPROT:Q15797 GENECARDS:SMAD1 REACTOME:64616 KEGG:4086 ATLASONC:GC_SMAD1 WIKI:SMAD1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="SMAD1"/> <bbox w="80.0" h="40.0" x="14704.0" y="3889.0"/> <glyph class="state variable" id="_4ee4c749-9244-4591-bf8b-ccf8ac322337"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14776.5" y="3884.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s262_wca1_wca3_sa208" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re67:(MAP:survival) PMID:19000719 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: notch 1 HUGO:NOTCH1 HGNC:7881 ENTREZ:4851 UNIPROT:P46531 GENECARDS:NOTCH1 REACTOME:60520 KEGG:4851 ATLASONC:NOTCH1ID30ch9q34 WIKI:NOTCH1 notch 2 HUGO:NOTCH2 HGNC:7882 ENTREZ:4853 UNIPROT:Q04721 GENECARDS:NOTCH2 REACTOME:60522 KEGG:4853 ATLASONC:NOTCH2ID41556ch1p12 WIKI:NOTCH2 notch 3 HUGO:NOTCH3 HGNC:7883 ENTREZ:4854 UNIPROT:Q9UM47 GENECARDS:NOTCH3 REACTOME:60524 KEGG:4854 ATLASONC:NOTCH3ID41557ch19p13 WIKI:NOTCH3 notch 4 HUGO:NOTCH4 HGNC:7884 ENTREZ:4855 UNIPROT:Q99466 GENECARDS:NOTCH4 REACTOME:60526 KEGG:4855 ATLASONC:GC_NOTCH4 WIKI:NOTCH4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="NICD*"/> <bbox w="80.0" h="40.0" x="14328.0" y="3624.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s289_wca1_wca3_sa226" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="12894.0" y="3624.0"/> <glyph class="state variable" id="_9f6b2bf2-71fd-48af-815b-3f6bd788cc30"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="12955.882" y="3659.0"/> </glyph> <glyph class="state variable" id="_c940b302-25de-48c9-8abe-4844b4429aa4"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="12876.992" y="3619.0"/> </glyph> <glyph class="state variable" id="_fe118957-f7f7-4da2-925e-c84a277ba181"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="12956.5" y="3619.2148"/> </glyph> <glyph class="state variable" id="_6ef4d177-7c46-4a70-b583-45b1017c2b06"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="12916.404" y="3659.0"/> </glyph> <glyph class="state variable" id="_295c02d7-28e4-4ac0-bf69-2799aa7eec7a"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="12916.532" y="3619.0"/> </glyph> <glyph class="state variable" id="_d62d1241-3662-452d-aa7b-a282077085ec"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="12876.5" y="3658.7224"/> </glyph> <glyph class="state variable" id="_133799e3-93b4-4600-915c-df7178287216"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12969.0" y="3619.0"/> </glyph> <glyph class="state variable" id="_d9197ec2-a6c5-449e-a94c-cadba43d602d"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="12956.5" y="3658.1306"/> </glyph> <glyph class="state variable" id="_e9232d89-4798-427c-b845-c32204b36661"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="12876.5" y="3658.7224"/> </glyph> <glyph class="state variable" id="_b39bd850-9d00-42af-b469-014bc18ff82c"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12881.992" y="3619.0"/> </glyph> <glyph class="state variable" id="_6f58ea4c-3aae-4b72-b36a-c6402cf94d94"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="12876.992" y="3619.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s304_wca1_wca3_sa233" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re78(MAP:survival): Site is adjacent to the NLS2 in APC PMID:11689703 s_wca3_re85:(MAP:survival) PMID:10984057 s_wca3_re91:(MAP:survival) PMID:11585828 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="12894.0" y="3763.0"/> <glyph class="state variable" id="_7b9cfc1d-8e78-444f-b5f1-8ed539237cec"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="12955.882" y="3798.0"/> </glyph> <glyph class="state variable" id="_282a04e0-8eb0-4dd3-8c16-62e7cd14ea71"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="12876.992" y="3758.0"/> </glyph> <glyph class="state variable" id="_0a35049b-6e7b-400d-885a-ef9c775ab87d"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="12956.5" y="3758.2148"/> </glyph> <glyph class="state variable" id="_260a5090-b898-4e75-a251-13f109b5972d"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="12916.404" y="3798.0"/> </glyph> <glyph class="state variable" id="_08245a7e-8af5-4bc4-a78e-691c97845333"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="12916.532" y="3758.0"/> </glyph> <glyph class="state variable" id="_69b34e1f-e20c-4786-ab97-9f59f776fdeb"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="12876.5" y="3797.7224"/> </glyph> <glyph class="state variable" id="_467ff72d-10a4-44df-9942-3a570132750f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12969.0" y="3758.0"/> </glyph> <glyph class="state variable" id="_3d9da501-94df-4c1d-bcf2-7669599c5532"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="12956.5" y="3797.1306"/> </glyph> <glyph class="state variable" id="_b2a075ed-75ae-4d9c-b5ab-20a2f871dbd4"> <state value="P" variable="S2034"/> <bbox w="40.0" h="10.0" x="12874.0" y="3797.7224"/> </glyph> <glyph class="state variable" id="_307e468d-a57b-4308-8f56-ca0230c55d30"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12881.992" y="3758.0"/> </glyph> <glyph class="state variable" id="_420ff282-65a2-4426-a6b2-6b8aae215013"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="12876.992" y="3758.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s305_wca1_wca3_sa234" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re93:(MAP:survival) Not known if this dissociation occurs (here or later) s_wca3_re85:(MAP:survival) PMID:10984057 s_wca3_re88:(MAP:survival) PMID:10984057 PMID:11263497 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="13406.375" y="3836.0"/> <glyph class="state variable" id="_0fd8b132-eed7-4abe-8f09-6beb4e988705"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="13468.257" y="3871.0"/> </glyph> <glyph class="state variable" id="_052bfe9d-5689-4591-b293-7478c2ba6fac"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="13389.367" y="3831.0"/> </glyph> <glyph class="state variable" id="_52199a84-f3f1-4070-8343-e2ad3291a6d1"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="13468.875" y="3831.2148"/> </glyph> <glyph class="state variable" id="_bfa44f79-6b79-4a7e-b257-0c380b2d9e22"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="13428.779" y="3871.0"/> </glyph> <glyph class="state variable" id="_02ea1099-6204-4db7-bd2b-c5d1e2588f5e"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="13428.907" y="3831.0"/> </glyph> <glyph class="state variable" id="_f337e00b-ff56-4209-89cc-0392cb39eb85"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="13388.875" y="3870.7224"/> </glyph> <glyph class="state variable" id="_2657d54c-7dd3-48c2-807c-ea363ca93da8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13481.375" y="3831.0"/> </glyph> <glyph class="state variable" id="_df6da948-d3d9-43c7-ba17-475c07b10a47"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="13468.875" y="3870.1306"/> </glyph> <glyph class="state variable" id="_d64ffa4e-078e-4cfd-9e84-cf0ac24f2f0e"> <state value="P" variable="S2034"/> <bbox w="40.0" h="10.0" x="13386.375" y="3870.7224"/> </glyph> <glyph class="state variable" id="_5f9c77cf-c68e-451b-94f0-6f4e495f027e"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13394.367" y="3831.0"/> </glyph> <glyph class="state variable" id="_39cba0b8-b83d-44a7-99ba-e0f89d375629"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="13389.367" y="3831.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s307_wca1_wca3_sa235" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re80:(MAP:survival) PMID:11689703 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="12893.75" y="3825.0"/> <glyph class="state variable" id="_6d8243e5-6ced-4ccb-b1df-ccdd92e3b536"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="12955.632" y="3860.0"/> </glyph> <glyph class="state variable" id="_d4cc9995-630b-45ad-aafc-a9e1b9ad1bdb"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="12876.742" y="3820.0"/> </glyph> <glyph class="state variable" id="_318928de-6cac-48a9-9a94-e7684867e365"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="12956.25" y="3820.2148"/> </glyph> <glyph class="state variable" id="_e26c4755-ef5c-41f1-95aa-c58cb1d72735"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="12916.154" y="3860.0"/> </glyph> <glyph class="state variable" id="_2f77190e-d133-4d26-b58b-2dd52fd8bcc1"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="12916.282" y="3820.0"/> </glyph> <glyph class="state variable" id="_ece4b9be-a8e1-4525-aff8-560d769f613c"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="12876.25" y="3859.7224"/> </glyph> <glyph class="state variable" id="_f111a856-897d-4314-a617-18781d742a4d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="12968.75" y="3820.0"/> </glyph> <glyph class="state variable" id="_6f573cc8-734c-4a5a-b63f-aece0bb3f619"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="12956.25" y="3859.1306"/> </glyph> <glyph class="state variable" id="_ae2f835e-a1f3-4306-ac1c-bd966c62f391"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="12876.25" y="3859.7224"/> </glyph> <glyph class="state variable" id="_6e7f6d08-abdd-4b9d-acc9-8c0fe5f1c743"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="12881.742" y="3820.0"/> </glyph> <glyph class="state variable" id="_68be4ba4-9b85-45b0-a005-a0dbfe7d3e6f"> <state value="P" variable="S2054"/> <bbox w="40.0" h="10.0" x="12874.242" y="3820.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s311_wca1_wca3_sa257" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re94:(MAP:survival) Not known if this dissociation occurs (here or later) s_wca3_re81:(MAP:survival) PMID:18744248 s_wca3_re84:(MAP:survival) PMID:10984057 s_wca3_re89:(MAP:survival) PMID:10984057 PMID:11263497 s_wca3_re95:(MAP:survival) PMID:22787431 s_wca3_re104:(MAP:survival) PMID:15525529 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: adenomatous polyposis coli HUGO:APC HGNC:583 ENTREZ:324 UNIPROT:P25054 GENECARDS:APC REACTOME:403429 KEGG:5624 ATLASONC:APC118 WIKI:APC "adenomatosis polyposis coli" Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="APC"/> <bbox w="80.0" h="40.0" x="13419.75" y="3627.0"/> <glyph class="state variable" id="_4e40a78a-2bc8-4bd1-9f09-bfd56672a0b4"> <state value="" variable="S1505"/> <bbox w="35.0" h="10.0" x="13481.632" y="3662.0"/> </glyph> <glyph class="state variable" id="_4dd1a0ce-30ac-4a9e-a35e-45a043d20a47"> <state value="" variable="S1501"/> <bbox w="35.0" h="10.0" x="13402.742" y="3622.0"/> </glyph> <glyph class="state variable" id="_9613df4d-d4f9-40e0-b5cd-0edee620a07e"> <state value="" variable="S1504"/> <bbox w="35.0" h="10.0" x="13482.25" y="3622.2148"/> </glyph> <glyph class="state variable" id="_699acb91-0673-4cf7-8afc-6654ea6a05f1"> <state value="" variable="S1507"/> <bbox w="35.0" h="10.0" x="13442.154" y="3662.0"/> </glyph> <glyph class="state variable" id="_03daa170-b254-48f8-bc27-82796d0fc08a"> <state value="" variable="S1503"/> <bbox w="35.0" h="10.0" x="13442.282" y="3622.0"/> </glyph> <glyph class="state variable" id="_5decc9c5-914e-4a67-adf8-fb1b39c71630"> <state value="" variable="S1510"/> <bbox w="35.0" h="10.0" x="13402.25" y="3661.7224"/> </glyph> <glyph class="state variable" id="_48ffe5d4-4016-4ad6-99ae-dbae57c738ca"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13494.75" y="3622.0"/> </glyph> <glyph class="state variable" id="_d8f24123-d667-4f37-a265-273cddf4705d"> <state value="" variable="T1487"/> <bbox w="35.0" h="10.0" x="13482.25" y="3661.1306"/> </glyph> <glyph class="state variable" id="_13379946-d095-4063-905c-4ce0b9f7515c"> <state value="" variable="S2034"/> <bbox w="35.0" h="10.0" x="13402.25" y="3661.7224"/> </glyph> <glyph class="state variable" id="_6b1e434e-e435-48e4-86de-bb404bafd85e"> <state value="" variable="K63"/> <bbox w="25.0" h="10.0" x="13407.742" y="3622.0"/> </glyph> <glyph class="state variable" id="_99b69813-936d-41a1-bffc-10b1657dfd1c"> <state value="" variable="S2054"/> <bbox w="35.0" h="10.0" x="13402.742" y="3622.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s312_wca1_wca3_sa240" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re79(MAP:survival): This transport is enhanced upon phosphorylation however it is not necessary for import of APC into nucleus PMID:11689703 PMID:15649893 PMID:11050185 PMID:12223464 s_wca3_re83(MAP:survival): Import of APC does not require phosphorylation of APC PMID:12223464 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: karyopherin alpha 2 (RAG cohort 1 importin alpha 1) Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="α-Importin*"/> <bbox w="80.0" h="40.0" x="13158.0" y="3724.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s313_wca1_wca3_sa241" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> </notes> <label text="CRM1*"/> <bbox w="80.0" h="40.0" x="13309.0" y="3742.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s326_wca1_wca3_sa250" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re90:(MAP:survival) PMID:11585828 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein phosphatase 2 regulatory subunit B' alpha HUGO:PPP2R5A HGNC:9309 ENTREZ:5525 UNIPROT:Q15172 GENECARDS:PPP2R5A REACTOME:49115 KEGG:5525 ATLASONC:GC_PPP2R5A WIKI:PPP2R5A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="B56α*"/> <bbox w="80.0" h="40.0" x="12931.0" y="3709.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s335_wca1_wca3_sa258" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re93:(MAP:survival) Not known if this dissociation occurs (here or later) References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: protein phosphatase 2 regulatory subunit B' alpha HUGO:PPP2R5A HGNC:9309 ENTREZ:5525 UNIPROT:Q15172 GENECARDS:PPP2R5A REACTOME:49115 KEGG:5525 ATLASONC:GC_PPP2R5A WIKI:PPP2R5A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="B56α*"/> <bbox w="80.0" h="40.0" x="13421.0" y="3772.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s347_wca1_wca3_sa266" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: mitogen-activated protein kinase 11 PRKM11 HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 mitogen-activated protein kinase 12 SAPK3 HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 mitogen-activated protein kinase 13 PRKM13 HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 mitogen-activated protein kinase 14 CSBP1 CSBP2 CSPB1 HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: mitogen-activated protein kinase 11 PRKM11 HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 GENECARDS:MAPK11 REACTOME:59299 KEGG:5600 ATLASONC:GC_MAPK11 WIKI:MAPK11 mitogen-activated protein kinase 12 SAPK3 HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 GENECARDS:MAPK12 REACTOME:69723 KEGG:6300 ATLASONC:MAPK12ID41290ch22q13 WIKI:MAPK12 mitogen-activated protein kinase 13 PRKM13 HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 GENECARDS:MAPK13 REACTOME:59303 KEGG:5603 ATLASONC:MAPK13ID41291ch6p21 WIKI:MAPK13 mitogen-activated protein kinase 14 CSBP1 CSBP2 CSPB1 HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 GENECARDS:MAPK14 REACTOME:405912 KEGG:1432 ATLASONC:MAPK14ID41292ch6p21 WIKI:MAPK14 Mxi2 P38 "P38 MAP kinase" PRKM14 PRKM15 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> Identifiers_begin: mitogen-activated protein kinase 11 PRKM11 HUGO:MAPK11 HGNC:6873 ENTREZ:5600 UNIPROT:Q15759 GENECARDS:MAPK11 REACTOME:59299 KEGG:5600 ATLASONC:GC_MAPK11 WIKI:MAPK11 mitogen-activated protein kinase 12 SAPK3 HUGO:MAPK12 HGNC:6874 ENTREZ:6300 UNIPROT:P53778 GENECARDS:MAPK12 REACTOME:69723 KEGG:6300 ATLASONC:MAPK12ID41290ch22q13 WIKI:MAPK12 mitogen-activated protein kinase 13 PRKM13 HUGO:MAPK13 HGNC:6875 ENTREZ:5603 UNIPROT:O15264 GENECARDS:MAPK13 REACTOME:59303 KEGG:5603 ATLASONC:MAPK13ID41291ch6p21 WIKI:MAPK13 mitogen-activated protein kinase 14 CSBP1 CSBP2 CSPB1 HUGO:MAPK14 HGNC:6876 ENTREZ:1432 UNIPROT:Q16539 GENECARDS:MAPK14 REACTOME:405912 KEGG:1432 ATLASONC:MAPK14ID41292ch6p21 WIKI:MAPK14 Mxi2 P38 "P38 MAP kinase" PRKM14 PRKM15 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="p38*"/> <bbox w="80.0" h="40.0" x="13085.0" y="3388.0"/> <glyph class="state variable" id="_1c5029b1-ebc5-4f4a-81b4-cc0363dce29c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13080.0" y="3410.4111"/> </glyph> <glyph class="state variable" id="_d680c414-1023-4204-a9be-f85d2bcc72c0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13080.0" y="3395.6816"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s362_wca1_wca3_sa276" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re103:(MAP:survival) PMID:15747065 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 transcription factor 7-like 1 (T-cell specific HMG-box) TCF3 HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 transcription factor 7-like 2 (T-cell specific HMG-box) TCF4 HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end</body> </html> </notes> <label text="LEF_TCF*"/> <bbox w="80.0" h="40.0" x="14017.75" y="4024.0"/> <glyph class="state variable" id="_c2a123ce-876d-4144-8e60-879036a7ed57"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14092.75" y="4019.878"/> </glyph> <glyph class="state variable" id="_9ccfd2b4-e516-47d0-a8a4-b523710573db"> <state value="P" variable="S40"/> <bbox w="30.0" h="10.0" x="14082.75" y="4055.614"/> </glyph> <glyph class="state variable" id="_8d5f4e65-0117-4137-bc76-b1234b44ef4b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14092.75" y="4039.0"/> </glyph> <glyph class="state variable" id="_25bcc694-b701-491b-99ba-c896f976a3dd"> <state value="" variable="S166"/> <bbox w="30.0" h="10.0" x="14003.242" y="4019.0"/> </glyph> <glyph class="state variable" id="_852a5500-0b5b-4342-b696-045668bf5a69"> <state value="" variable="T155"/> <bbox w="30.0" h="10.0" x="14002.75" y="4058.7224"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s363_wca1_wca3_sa277" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re103:(MAP:survival) PMID:15747065 s_wca3_re107:(MAP:survival) PMID:15327769 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CK1δ*"/> <bbox w="80.0" h="40.0" x="14117.0" y="4075.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s364_wca1_wca3_sa278" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re111:(MAP:survival) PMID:16510874 s_wca3_re105:(MAP:survival) PMID:15037661 s_wca3_re118:(MAP:survival) PMID:10756197 s_wca3_re127:(MAP:survival) PMID:19901072 PMID:19751731 s_wca3_re140:(MAP:survival) PMID:15708980 PMID:14567915 s_wca3_re144(MAP:survival): This complex does not contain HDAC but do contain LEF1 PMID:17666529 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: C-terminal binding protein 1 HUGO:CTBP1 HGNC:2494 ENTREZ:1487 UNIPROT:Q13363 GENECARDS:CTBP1 KEGG:1487 ATLASONC:GC_CTBP1 WIKI:CTBP1 C-terminal binding protein 2 HUGO:CTBP2 HGNC:2495 ENTREZ:1488 UNIPROT:P56545 GENECARDS:CTBP2 ATLASONC:GC_CTBP2 WIKI:CTBP2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTBP*"/> <bbox w="80.0" h="40.0" x="13159.0" y="4310.0"/> <glyph class="state variable" id="_2925edc0-e0a1-4b14-bb50-510eec2c7c8b"> <state value="" variable="S422"/> <bbox w="30.0" h="10.0" x="13224.0" y="4305.215"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="wca1_s_wca3_s368_wca1_wca3_sa281" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re105:(MAP:survival) PMID:15037661 s_wca3_re104:(MAP:survival) PMID:15525529 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: C-terminal binding protein 1 HUGO:CTBP1 HGNC:2494 ENTREZ:1487 UNIPROT:Q13363 GENECARDS:CTBP1 KEGG:1487 ATLASONC:GC_CTBP1 WIKI:CTBP1 C-terminal binding protein 2 HUGO:CTBP2 HGNC:2495 ENTREZ:1488 UNIPROT:P56545 GENECARDS:CTBP2 ATLASONC:GC_CTBP2 WIKI:CTBP2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTBP*"/> <bbox w="86.0" h="46.0" x="13282.0" y="4310.0"/> <glyph class="unit of information" id="_eb6e7dff-ff8e-4df1-b395-00024bbb9a96"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="13315.0" y="4305.0"/> </glyph> <glyph class="state variable" id="_a8707e89-b29d-4499-9daf-9173d687088d"> <state value="" variable="S422"/> <bbox w="30.0" h="10.0" x="13353.0" y="4305.247"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s369_wca1_wca3_sa282" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re105:(MAP:survival) PMID:15037661 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 6 14kDa "NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 6 (14kD B14)" HUGO:NDUFA6 HGNC:7690 ENTREZ:4700 UNIPROT:P56556 GENECARDS:NDUFA6 REACTOME:59933 KEGG:4700 WIKI:NDUFA6 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="NDUFA6"/> <bbox w="80.0" h="40.0" x="13220.0" y="4395.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s427_wca1_wca3_sa326" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re114(MAP:survival): KLF8 recruits P300 PMID:22761862 PMID:20107328 s_wca3_re118:(MAP:survival) PMID:10756197 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Kruppel-like factor 8 HUGO:KLF8 HGNC:6351 ENTREZ:11279 UNIPROT:O95600 GENECARDS:KLF8 KEGG:11279 ATLASONC:GC_KLF8 WIKI:KLF8 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="KLF8"/> <bbox w="80.0" h="40.0" x="13390.0" y="3907.0"/> <glyph class="state variable" id="_3b31210a-11e7-4051-b215-e3c89317a50c"> <state value="" variable="K95"/> <bbox w="25.0" h="10.0" x="13457.5" y="3940.379"/> </glyph> <glyph class="state variable" id="_75e432b4-f27e-4d1c-9618-ae3538d6f275"> <state value="" variable="K67"/> <bbox w="25.0" h="10.0" x="13377.5" y="3902.9302"/> </glyph> <glyph class="state variable" id="_253b9865-c5c1-444f-99ab-5962523ffca7"> <state value="" variable="K93"/> <bbox w="25.0" h="10.0" x="13456.349" y="3902.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s457_wca1_wca3_sa345" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc3_re16(MAP:survival): Sequential sumoylion of NFAT1, might also occur in NFAT3 and 4. There is no special character for sumoylation in CellDesigner, so this is indicated by a "?". Lys684 is targeted firstly, followed by Lys897. PMID:15117942 s_wnc3_re18(MAP:survival): Order of sumoylation is not important. PMID:19218564 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Protein inhibitor of activated STAT 1 HUGO:PIAS1 HGNC:2752 ENTREZ:8554 UNIPROT:O75925 GENECARDS:PIAS1 REACTOME:61690 KEGG:8554 ATLASONC:GC_PIAS1 WIKI:PIAS1 DDXBP1 "DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20711444 References_end Identifiers_begin: Protein inhibitor of activated STAT 1 HUGO:PIAS1 HGNC:2752 ENTREZ:8554 UNIPROT:O75925 GENECARDS:PIAS1 REACTOME:61690 KEGG:8554 ATLASONC:GC_PIAS1 WIKI:PIAS1 DDXBP1 "DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20711444 References_end Identifiers_begin: Protein inhibitor of activated STAT 1 HUGO:PIAS1 HGNC:2752 ENTREZ:8554 UNIPROT:O75925 GENECARDS:PIAS1 REACTOME:61690 KEGG:8554 ATLASONC:GC_PIAS1 WIKI:PIAS1 DDXBP1 "DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20711444 References_end</body> </html> </notes> <label text="PIAS1"/> <bbox w="80.0" h="40.0" x="13266.0" y="4582.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s535_wca1_wca3_sa383" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re135:(MAP:survival) PMID:12050133 PPMID:12441302 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: SIX homeobox 3 "holoprosencephaly 2 alobar or semilobar" HPE2 "sine oculis homeobox homolog 3 (Drosophila)" HUGO:SIX3 HGNC:10889 ENTREZ:6496 UNIPROT:O95343 GENECARDS:SIX3 KEGG:6496 ATLASONC:GC_SIX3 WIKI:SIX3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="SIX3"/> <bbox w="80.0" h="40.0" x="13712.0" y="5264.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s542_wca1_wca3_sa389" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re138:(MAP:survival) PMID:20925119 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: amino-terminal enhancer of split HUGO:AES HGNC:307 ENTREZ:166 UNIPROT:Q08117 GENECARDS:AES KEGG:166 ATLASONC:GC_AES WIKI:AES Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="AES"/> <bbox w="80.0" h="40.0" x="14326.0" y="3806.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s550_wca1_wca3_sa392" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re139:(MAP:survival) PMID:19183803 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: homeodomain interacting protein kinase 1 HUGO:HIPK1 HGNC:19006 ENTREZ:204851 UNIPROT:Q86Z02 GENECARDS:HIPK1 KEGG:204851 ATLASONC:GC_HIPK1 WIKI:HIPK1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HIPK1"/> <bbox w="80.0" h="40.0" x="14683.0" y="4238.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s551_wca1_wca3_sa393" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re168(MAP:survival): contains NLS import higher when stimulated with wnt3 PMID:15720724 s_wca3_re139:(MAP:survival) PMID:19183803 s_wca3_re167(MAP:survival): Contains a NES s_wca3_re169(MAP:survival): Upon WNT3a stimulation formation complex DVL with c-jun PMID:18347071 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="14685.0" y="4312.0"/> <glyph class="state variable" id="_6125b3b8-fe8d-4783-ad6e-30189cbaf9ae"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14760.0" y="4307.0"/> </glyph> <glyph class="state variable" id="_7490d294-ada1-40ca-b617-64cdb28f15f7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14680.0" y="4307.0"/> </glyph> <glyph class="state variable" id="_20a35498-2b87-4da5-8fd2-e540edd835b3"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="14749.382" y="4347.0"/> </glyph> <glyph class="state variable" id="_0c530836-8e04-4f3a-9b73-4a1aacb2128a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14680.0" y="4307.0"/> </glyph> <glyph class="state variable" id="_4080956b-5e25-4b73-b7b6-91cdd29db299"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14760.0" y="4307.0"/> </glyph> <glyph class="state variable" id="_c43616aa-ff3b-4fa0-9ca9-ba734640b801"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14759.634" y="4307.0"/> </glyph> <glyph class="state variable" id="_6aec6afe-44d3-4c59-9bf1-f936a9428eff"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14760.0" y="4347.0"/> </glyph> <glyph class="state variable" id="_6268df5a-f9d5-4a53-afa4-60a662d3d057"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="14670.0" y="4346.722"/> </glyph> <glyph class="state variable" id="_f2d34b67-792a-47a8-a7c4-d4052f38d363"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14680.0" y="4347.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s555_wca1_wca3_sa396" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re28(MAP:survival): PMID:21118996 PMID:15082531 Auto-phosphorylation HIPK2 may induce autophoshorylationMaps_Modules_end s_wca3_re140:(MAP:survival) PMID:15708980 PMID:14567915 s_wca3_re144(MAP:survival): This complex does not contain HDAC but do contain LEF1 PMID:17666529 s_wca3_re146(MAP:survival): HIPK2 phosphorylates any TCF/LEF PMID:21285352 s_wca3_re148(MAP:survival): HIPK2 represses transcription of Vim and thus EMT PMID:22236966 s_wca3_re149(MAP:survival): HIPK2 phosphorylates S33 and S37 residues as GSK3 without priming b-catenin first PMID:20307497 s_wnc4_re8:(MAP:survival) PMID:15526030 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: homeodomain interacting protein kinase 2 "homeodomain-interacting protein kinase 2" HUGO:HIPK2 HGNC:14402 ENTREZ:28996 UNIPROT:Q9H2X6 GENECARDS:HIPK2 KEGG:28996 ATLASONC:HIPK2ID40824ch7q34 WIKI:HIPK2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: HIPK2 is pre-dominantly present in the nucleus PMID:18974774 References_end Identifiers_begin: homeodomain interacting protein kinase 2 "homeodomain-interacting protein kinase 2" HUGO:HIPK2 HGNC:14402 ENTREZ:28996 UNIPROT:Q9H2X6 GENECARDS:HIPK2 KEGG:28996 ATLASONC:HIPK2ID40824ch7q34 WIKI:HIPK2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: HIPK2 is pre-dominantly present in the nucleus PMID:18974774 References_end</body> </html> </notes> <label text="HIPK2"/> <bbox w="80.0" h="40.0" x="13633.0" y="4040.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s556_wca1_wca3_sa397" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re140:(MAP:survival) PMID:15708980 PMID:14567915 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: C-terminal binding protein 1 HUGO:CTBP1 HGNC:2494 ENTREZ:1487 UNIPROT:Q13363 GENECARDS:CTBP1 KEGG:1487 ATLASONC:GC_CTBP1 WIKI:CTBP1 C-terminal binding protein 2 HUGO:CTBP2 HGNC:2495 ENTREZ:1488 UNIPROT:P56545 GENECARDS:CTBP2 ATLASONC:GC_CTBP2 WIKI:CTBP2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CTBP*"/> <bbox w="80.0" h="40.0" x="13159.0" y="4212.0"/> <glyph class="state variable" id="_c76f6a7f-8541-4297-b2b3-fcc4212cd4c5"> <state value="P" variable="S422"/> <bbox w="35.0" h="10.0" x="13221.5" y="4207.215"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s582_wca1_wca3_sa416" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re147(MAP:survival): Phosphorylated TCF/LEF transcription factor dissociates and is replaced by another unphosphorylated one. For example TCF3 (repressor) is phosphorylated by HIPK2 and will dissociate from the complex and is replaced by TCF1. PMID:21285352 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 transcription factor 7-like 1 (T-cell specific HMG-box) TCF3 HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 transcription factor 7-like 2 (T-cell specific HMG-box) TCF4 HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end</body> </html> </notes> <label text="LEF_TCF*"/> <bbox w="80.0" h="40.0" x="14442.75" y="4086.0"/> <glyph class="state variable" id="_5c22ab68-9d2e-4df9-9fd2-f60b82aba65a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14517.75" y="4081.878"/> </glyph> <glyph class="state variable" id="_791badcc-454d-4ea0-8908-fb3c1a20aa08"> <state value="" variable="S40"/> <bbox w="25.0" h="10.0" x="14510.25" y="4117.6143"/> </glyph> <glyph class="state variable" id="_b0fd1834-0a94-4548-8815-fa41dc7cc70f"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14515.25" y="4101.0"/> </glyph> <glyph class="state variable" id="_03d88f59-57aa-49cd-9051-ca70b489eea3"> <state value="" variable="S166"/> <bbox w="30.0" h="10.0" x="14428.242" y="4081.0"/> </glyph> <glyph class="state variable" id="_1c233eec-885d-4ad6-826b-c6c9f9e19c55"> <state value="" variable="T155"/> <bbox w="30.0" h="10.0" x="14427.75" y="4120.722"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s588_wca1_wca3_sa418" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re149(MAP:survival): HIPK2 phosphorylates S33 and S37 residues as GSK3 without priming b-catenin first PMID:20307497 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="13843.0" y="3656.0"/> <glyph class="state variable" id="_35f3d4d9-3276-43a4-a1a7-4c1fa56954a8"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="13870.404" y="3691.0"/> </glyph> <glyph class="state variable" id="_fb11f977-a669-432a-a76e-a8dba73a2567"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="13909.882" y="3691.0"/> </glyph> <glyph class="state variable" id="_3fefefde-297a-437c-a973-5e687a6a4008"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="13910.5" y="3651.2148"/> </glyph> <glyph class="state variable" id="_49a2742f-2d18-454f-aff5-971ccea43ecf"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="13870.532" y="3651.0"/> </glyph> <glyph class="state variable" id="_bca517f4-f2fb-46dc-a1c0-d1a781c5dc11"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="13830.992" y="3651.0"/> </glyph> <glyph class="state variable" id="_2b4a643a-f16a-4859-b6a0-d559d152a14a"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="13830.5" y="3690.7224"/> </glyph> <glyph class="state variable" id="_039e1a79-e040-4fcc-87db-1aff67d97250"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="13908.0" y="3651.2148"/> </glyph> <glyph class="state variable" id="_c379b984-4ca5-4ea3-8c6e-535d64dfde70"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="13908.0" y="3651.2148"/> </glyph> <glyph class="state variable" id="_0885119e-74de-4666-a1a8-2cc7b7cd5100"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="13838.0" y="3671.0"/> </glyph> <glyph class="state variable" id="_d584227f-7ba7-481e-9cb7-3928444faa40"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="13828.492" y="3651.0"/> </glyph> <glyph class="state variable" id="_cd6a4945-b34e-4132-8a44-65792732c714"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="13908.0" y="3651.2148"/> </glyph> <glyph class="state variable" id="_99e1d35c-ef94-4552-9d53-edd5c34c26c6"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="13835.5" y="3662.7158"/> </glyph> <glyph class="state variable" id="_1f6ca784-23bc-4581-85a6-ce521227c9c5"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="13908.0" y="3651.2148"/> </glyph> <glyph class="state variable" id="_f29d1887-3396-45c1-8aa5-80fd264d31a6"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="13835.5" y="3671.0"/> </glyph> <glyph class="state variable" id="_48e52cc4-b3b3-4dc7-923f-a55660a94fe4"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="13907.382" y="3691.0"/> </glyph> <glyph class="state variable" id="_8a88fa07-6242-453b-a598-f7cecd0152af"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="13908.0" y="3651.2148"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s607_wca1_wca3_sa432" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca4_re40:(MAP:survival) PMID:15611123 s_wca3_re151:(MAP:survival) PMID:22322943 s_wnc4_re20:(MAP:survival) PMID:22745173 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="AXIN2"/> <bbox w="80.0" h="40.0" x="14688.0" y="5197.25"/> <glyph class="state variable" id="_90472440-9aff-422d-97d4-3bdaf5f38e08"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14763.0" y="5192.25"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s608_wca1_wca3_sa147" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re151:(MAP:survival) PMID:22322943 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="UBCH10*"/> <clone/> <bbox w="80.0" h="40.0" x="13804.5" y="4208.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s608_wca1_wca3_sa435" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re151:(MAP:survival) PMID:22322943 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="UBCH10*"/> <clone/> <bbox w="80.0" h="40.0" x="14893.0" y="5122.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s609_wca1_wca3_sa433" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re151:(MAP:survival) PMID:22322943 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="AXIN2"/> <bbox w="80.0" h="40.0" x="14872.0" y="5197.0"/> <glyph class="state variable" id="_2b835616-35c9-45b1-a771-f78f0ed4ec42"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="14942.0" y="5192.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s617_wca1_wca3_sa440" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re154(MAP:survival): SOX9 PMID:23306204 p300 transcription complex PMID:15806138 WNT-target gene: PMID:20122174 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: SRY (sex determining region Y)-box 9 "campomelic dysplasia autosomal sex-reversal" CMD1 CMPD1 HUGO:SOX9 HGNC:11204 ENTREZ:6662 UNIPROT:P48436 GENECARDS:SOX9 KEGG:6662 ATLASONC:GC_SOX9 WIKI:SOX9 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="SOX9"/> <bbox w="80.0" h="40.0" x="13961.0" y="5061.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s661_wca1_wca3_sa456" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: insulin receptor substrate 2 HUGO:IRS2 HGNC:6126 ENTREZ:8660 UNIPROT:Q9Y4H2 GENECARDS:IRS2 REACTOME:57529 KEGG:8660 ATLASONC:GC_IRS2 WIKI:IRS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="IRS2"/> <bbox w="80.0" h="50.0" x="14218.0" y="5531.0"/> <glyph class="unit of information" id="_166b68bf-2ab1-45c3-acf3-9497d041ff1e"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="14235.5" y="5526.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s670_wca1_wca3_sa462" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 dishevelled dsh homolog 2 (Drosophila) HUGO:DVL2 HGNC:3086 ENTREZ:1856 UNIPROT:O14641 GENECARDS:DVL2 REACTOME:53996 ATLASONC:GC_DVL2 WIKI:DVL2 dishevelled dsh homolog 3 (Drosophila) HUGO:DVL3 HGNC:3087 ENTREZ:1857 UNIPROT:Q92997 GENECARDS:DVL3 ATLASONC:GC_DVL3 WIKI:DVL3 "dishevelled 1 (homologous to Drosophila dsh)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20006983 References_end</body> </html> </notes> <label text="DVL*"/> <bbox w="80.0" h="40.0" x="15172.0" y="4360.0"/> <glyph class="state variable" id="_70dfdd45-3cc8-483f-aadd-7a7582ab534f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15247.0" y="4355.0"/> </glyph> <glyph class="state variable" id="_a9d10b06-e210-401c-be24-46cff3de937f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15167.0" y="4355.0"/> </glyph> <glyph class="state variable" id="_53dbbcce-d982-450e-b325-cff645a57f8d"> <state value="" variable="S139"/> <bbox w="30.0" h="10.0" x="15236.382" y="4395.0"/> </glyph> <glyph class="state variable" id="_17fc5fba-8b1b-481a-9454-5a5208fc9a35"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15167.0" y="4355.0"/> </glyph> <glyph class="state variable" id="_3250428e-cafa-42ad-8581-bd63182d71bf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15247.0" y="4355.0"/> </glyph> <glyph class="state variable" id="_bb094b07-3577-4a5c-a5a7-58af5d34e97f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15246.634" y="4355.0"/> </glyph> <glyph class="state variable" id="_cbd6cd20-6119-4ea6-b98d-df65d7123387"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15247.0" y="4395.0"/> </glyph> <glyph class="state variable" id="_6915d3bf-d0d1-4b42-92d7-7514f09f6ce2"> <state value="" variable="S142"/> <bbox w="30.0" h="10.0" x="15157.0" y="4394.722"/> </glyph> <glyph class="state variable" id="_fd5503b7-b566-4a1f-95b3-21ea86f9778c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15167.0" y="4395.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca3_s675_wca1_wca3_sa463" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re169(MAP:survival): Upon WNT3a stimulation formation complex DVL with c-jun PMID:18347071 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> </notes> <label text="JUN"/> <bbox w="80.0" h="40.0" x="14553.0" y="4312.0"/> <glyph class="state variable" id="_a6c54a1f-bfe6-4f2c-b498-4cb3d2b382bd"> <state value="" variable="S63"/> <bbox w="25.0" h="10.0" x="14540.992" y="4307.0"/> </glyph> <glyph class="state variable" id="_43047f34-d07b-4d3c-b1f3-c0aaa50c960a"> <state value="" variable="S73"/> <bbox w="25.0" h="10.0" x="14580.532" y="4307.0"/> </glyph> <glyph class="state variable" id="_108ef2f8-0527-48e2-be2c-ed1b59b1f5c8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="14548.0" y="4327.0"/> </glyph> <glyph class="state variable" id="_d32c8fd6-4064-4651-9130-9739770a3ee7"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14545.5" y="4307.0"/> </glyph> <glyph class="state variable" id="_4de964dd-49c9-44b7-ab34-a00c37d19a1e"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="14545.5" y="4347.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s31_wca1_wca3_sa26" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re125(MAP:survival): CBP-mediated transcription effects genes that are involved in stemm cell or progenitor cell maintenance and proliferation PMID:20920541 Repressor complex is default present on the enhance of wnt-target genes PMID:16510874 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RNA"/> <clone/> <bbox w="90.0" h="25.0" x="14337.0" y="4555.5"/> <glyph class="unit of information" id="_0ac1b574-7221-4b8d-82ba-5de796fe3ac9"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="14372.0" y="4550.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s31_wca1_wca3_sa359" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re125(MAP:survival): CBP-mediated transcription effects genes that are involved in stemm cell or progenitor cell maintenance and proliferation PMID:20920541 Repressor complex is default present on the enhance of wnt-target genes PMID:16510874 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Maps_Modules_begin: MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RNA"/> <clone/> <bbox w="90.0" h="25.0" x="14323.0" y="4622.75"/> <glyph class="unit of information" id="_20ec8d96-2f08-4bf8-a34e-4a6e7e97ef4e"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="14358.0" y="4617.75"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s142_wca1_wca3_sa110" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re19:(MAP:survival) PMID:16491118 s_wca3_re161:(MAP:survival) PMID:22020335 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dickkopf 1 homolog (Xenopus laevis) "dickkopf (Xenopus laevis) homolog 1" HUGO:DKK1 HGNC:2891 ENTREZ:22943 UNIPROT:O94907 GENECARDS:DKK1 KEGG:22943 ATLASONC:DKK1ID44007ch10q11 WIKI:DKK1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="DKK1"/> <bbox w="90.0" h="25.0" x="13277.0" y="5217.5"/> <glyph class="unit of information" id="_499d5f15-e513-4c90-9b3a-c8e66301bcb6"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="13312.0" y="5212.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s200_wca1_wca3_sa160" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re38:(MAP:survival) PMID:18519670 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: transducin-like enhancer of split 1 (E(sp1) homolog Drosophila) "transducin-like enhancer of split 1 homolog of Drosophila E(sp1)" HUGO:TLE1 HGNC:11837 ENTREZ:7088 UNIPROT:Q04724 GENECARDS:TLE1 REACTOME:66083 KEGG:7088 ATLASONC:GC_TLE1 WIKI:TLE1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TLE1"/> <bbox w="90.0" h="25.0" x="13277.0" y="5177.5"/> <glyph class="unit of information" id="_58544949-5b2c-4bb8-aada-a14f735a40c6"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="13312.0" y="5172.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s242_wca1_wca3_sa190" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re44(MAP:survival): Mi-2/NuRD PMID:22290435 SWI/SNF s_wca3_re49:(MAP:survival) PMID:22045851 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LEF1"/> <bbox w="90.0" h="25.0" x="13260.5" y="4869.6426"/> <glyph class="unit of information" id="_1fc21910-2056-4903-bef9-fc3db95a6be0"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="13295.5" y="4864.6426"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s243_wca1_wca3_sa191" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re45:(MAP:survival) PMID:20710043 s_wca3_re52:(MAP:survival) PMID:22045851 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 1 INT1 HUGO:WNT1 HGNC:12774 ENTREZ:7471 UNIPROT:P04628 GENECARDS:WNT1 REACTOME:67376 KEGG:7471 ATLASONC:GC_WNT1 WIKI:WNT1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="WNT1"/> <bbox w="90.0" h="25.0" x="13260.5" y="4903.3574"/> <glyph class="unit of information" id="_25c943f8-2d7a-47aa-81cb-56d504f46ea6"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="13295.5" y="4898.3574"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s244_wca1_wca3_sa192" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re55:(MAP:survival) PMID:22045851 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 3 INT4 HUGO:WNT3 HGNC:12782 ENTREZ:7473 UNIPROT:P56703 GENECARDS:WNT3 REACTOME:67380 KEGG:7473 ATLASONC:GC_WNT3 WIKI:WNT3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="WNT3"/> <bbox w="90.0" h="25.0" x="13260.5" y="4937.0713"/> <glyph class="unit of information" id="_74888efd-3a2c-48dc-a17c-18d06ea3a1a8"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="13295.5" y="4932.0713"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s245_wca1_wca3_sa193" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re58:(MAP:survival) PMID:22045851 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: low density lipoprotein receptor-related protein 6 HUGO:LRP6 HGNC:6698 ENTREZ:4040 UNIPROT:O75581 GENECARDS:LRP6 KEGG:4040 ATLASONC:GC_LRP6 WIKI:LRP6 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="LRP6"/> <bbox w="90.0" h="25.0" x="13260.5" y="4970.7856"/> <glyph class="unit of information" id="_2a5f2fad-93f8-44c0-b328-1121151e9e9a"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="13295.5" y="4965.7856"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s246_wca1_wca3_sa194" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc4_re22(MAP:survival): c-Raf; MEK1/2; ERK1/2;HRAS PMID:19906679 TGF-b1 in airway smooth muscle cells PMID:21908588 s_wca3_re61:(MAP:survival) PMID:22045851 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 ; ; ; Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 ; ; ; Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="90.0" h="25.0" x="13260.5" y="5004.5"/> <glyph class="unit of information" id="_f50e7bbb-5893-47ea-afc8-07b8b70ba65d"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="13295.5" y="4999.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s259_wca1_wca3_sa206" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re65(MAP:survival): PMID:22761862 Smad1 alone inhibits myc expression while b-catenin/TCF4 activates gene expression. Highest gene expression obtained when SMAD1/b-catenin/TCF4 complex is formed PMID:15576399 Mi-2/NuRD PMID:22290435 s_wnc3_re2:(MAP:survival) PMID:20516082 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) "v-myc avian myelocytomatosis viral oncogene homolog" HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 GENECARDS:MYC REACTOME:59773 KEGG:4609 ATLASONC:MYCID27 WIKI:MYC Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: v-myc myelocytomatosis viral oncogene homolog (avian) "v-myc avian myelocytomatosis viral oncogene homolog" HUGO:MYC HGNC:7553 ENTREZ:4609 UNIPROT:P01106 GENECARDS:MYC REACTOME:59773 KEGG:4609 ATLASONC:MYCID27 WIKI:MYC Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MYC"/> <bbox w="90.0" h="25.0" x="14876.0" y="4396.5"/> <glyph class="unit of information" id="_5834eb5f-a2f1-419b-bc8b-7b55022287af"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="14911.0" y="4391.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s267_wca1_wca3_sa212" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re69(MAP:survival): Synergistic effect on HES1 transcription PMID:19000719 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: hairy and enhancer of split 1 (Drosophila) "hairy homolog (Drosophila)" HRY HUGO:HES1 HGNC:5192 ENTREZ:3280 UNIPROT:Q14469 GENECARDS:HES1 REACTOME:56466 KEGG:3280 ATLASONC:GC_HES1 WIKI:HES1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="HES1"/> <bbox w="90.0" h="25.0" x="14402.0" y="3755.0"/> <glyph class="unit of information" id="_73a9bd0e-a1df-470f-a519-b10a5f252a07"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="14437.0" y="3750.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s273_wca1_wca3_sa217" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: nitric oxide synthase 2 inducible "nitric oxide synthase 2A (inducible hepatocytes)" NOS2A HUGO:NOS2 HGNC:7873 ENTREZ:4843 UNIPROT:P35228 GENECARDS:NOS2 REACTOME:60486 KEGG:4843 ATLASONC:GC_NOS2 WIKI:NOS2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="NOS2"/> <bbox w="90.0" h="25.0" x="14686.0" y="3807.5"/> <glyph class="unit of information" id="_b4c62f3e-661a-493c-856e-bdc84abe6aa8"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="14721.0" y="3802.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s422_wca1_wca3_sa325" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re113:(MAP:survival) PMID:21416054 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Kruppel-like factor 4 (gut) HUGO:KLF4 HGNC:6348 ENTREZ:9314 UNIPROT:O43474 GENECARDS:KLF4 REACTOME:58119 KEGG:9314 ATLASONC:KLF4ID44316ch9q31 WIKI:KLF4 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="KLF4"/> <bbox w="90.0" h="25.0" x="13523.0" y="5183.5"/> <glyph class="unit of information" id="_93017650-f6b0-47fc-b335-ff91e84304b5"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="13558.0" y="5178.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s449_wca1_wca3_sa338" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 PMID:20673124 References_end Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 PMID:20673124 References_end</body> </html> Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 PMID:20673124 References_end</body> </html> </notes> <label text="CyclinD*"/> <bbox w="90.0" h="25.0" x="14876.0" y="4437.0"/> <glyph class="unit of information" id="_42fd47bc-51ce-4187-912a-e5ae3eee99dc"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="14911.0" y="4432.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s451_wca1_wca3_sa340" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re117:(MAP:survival) PMID:22761862 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: axin 1 HUGO:AXIN1 HGNC:903 ENTREZ:8312 UNIPROT:O15169 GENECARDS:AXIN1 REACTOME:50579 KEGG:8312 ATLASONC:AXIN1ID379ch16p13 WIKI:AXIN1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="AXIN1"/> <bbox w="90.0" h="25.0" x="14876.0" y="4477.5"/> <glyph class="unit of information" id="_0a326a78-2eef-4720-89b8-7a0a6cc5cc89"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="14911.0" y="4472.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s465_wca1_wca3_sa347" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re121:(MAP:survival) PMID:21416054 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cadherin 1 type 1 E-CADHERIN (epithelial) UVO HUGO:CDH1 HGNC:1748 ENTREZ:999 UNIPROT:P12830 GENECARDS:CDH1 REACTOME:51210 KEGG:999 ATLASONC:CDH1ID166ch16q22 WIKI:CDH1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="E-Cadherin*"/> <bbox w="90.0" h="25.0" x="13523.0" y="5224.5"/> <glyph class="unit of information" id="_8c5328fc-9696-4f1b-b435-d66a5c9e9631"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="13558.0" y="5219.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s467_wca1_wca3_sa349" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re122(MAP:survival): Not sure if this mechanism is exact the same as for CYCLIND Myc and AXIN1 transcription. However it has been shown that KLF8 and b-catenin induces transcription of MMP9 gene. PMID:21151179 PMID:17306568 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: matrix metallopeptidase 9 (gelatinase B 92kDa gelatinase 92kDa type IV collagenase) CLG4B "matrix metalloproteinase 9 (gelatinase B 92kD gelatinase 92kD type IV collagenase)" "matrix metalloproteinase 9 (gelatinase B 92kDa gelatinase 92kDa type IV collagenase)" HUGO:MMP9 HGNC:7176 ENTREZ:4318 UNIPROT:P14780 GENECARDS:MMP9 REACTOME:59395 KEGG:4318 ATLASONC:MMP9ID41408ch20q11 WIKI:MMP9 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:ECM MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MMP9"/> <bbox w="90.0" h="25.0" x="14876.0" y="4516.5"/> <glyph class="unit of information" id="_dd430d70-9366-46e6-a932-36bcddfac26f"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="14911.0" y="4511.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s521_wca1_wca3_sa378" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re131(MAP:survival): Mi-2/NuRD PMID:22290435 s_wca4_re4(MAP:survival): PMID:22699938 E2F1 PMID:15766563 s_wca3_re132(MAP:survival): Actually the whole MIR-34 family targets AXIN2 PMID:22421157 s_wca4_re40:(MAP:survival) PMID:15611123 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="AXIN2"/> <bbox w="90.0" h="25.0" x="13260.5" y="5041.5"/> <glyph class="unit of information" id="_8ff2e0c7-8985-415c-b1d0-1e0ebd4dfce4"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="13295.5" y="5036.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s533_wca1_wca3_sa381" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re133(MAP:survival): MTA1 HDAC2 were shown together with NuRD to bind to six3-promoter region. PMID:20682799 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: SIX homeobox 3 "holoprosencephaly 2 alobar or semilobar" HPE2 "sine oculis homeobox homolog 3 (Drosophila)" HUGO:SIX3 HGNC:10889 ENTREZ:6496 UNIPROT:O95343 GENECARDS:SIX3 KEGG:6496 ATLASONC:GC_SIX3 WIKI:SIX3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="SIX3"/> <bbox w="90.0" h="25.0" x="13523.0" y="5272.5"/> <glyph class="unit of information" id="_797ac411-6814-4a9a-bafb-d7a16704abc6"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="13558.0" y="5267.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s616_wca1_wca3_sa439" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re154(MAP:survival): SOX9 PMID:23306204 p300 transcription complex PMID:15806138 WNT-target gene: PMID:20122174 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TCF4"/> <bbox w="90.0" h="25.0" x="14131.0" y="5201.5"/> <glyph class="unit of information" id="_f33a585d-54fd-4177-bec5-695cb976496a"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="14166.0" y="5196.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s619_wca1_wca3_sa442" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re155(MAP:survival): Transcription complex containing b-catenin and P300 PMID:17050667 PMID:21767405 RAD6B is overexpressed in breast cancer PMID:11929833 RAD6B upregulated in invasive breast cancer PMID:22705350 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquitin-conjugating enzyme E2B "ubiquitin-conjugating enzyme E2B (RAD6 homolog)" HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="RAD6B*"/> <bbox w="90.0" h="25.0" x="14131.0" y="5243.5"/> <glyph class="unit of information" id="_68c2be1f-3049-47ed-9c0b-ff88c6b0764a"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="14166.0" y="5238.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s631_wca1_wca3_sa445" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re157(MAP:survival): BCL9 is a target gene of the wnt pathway. PMID:18627596 However not known which transcription complex is involved either with CBP or P300. I have chosen this complex randomly References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: B-cell CLL/lymphoma 9 HUGO:BCL9 HGNC:1008 ENTREZ:607 UNIPROT:O00512 GENECARDS:BCL9 KEGG:607 ATLASONC:BCL9ID466 WIKI:BCL9 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="BCL9"/> <bbox w="90.0" h="25.0" x="14358.0" y="5158.5"/> <glyph class="unit of information" id="_40ec45bb-402f-474d-90a6-de644d233a59"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="14393.0" y="5153.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s660_wca1_wca3_sa455" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re163(MAP:survival): Though not known if this transcription is mediated by CBP in the transcripoition complex could be otherwise P300 PMID:23296977 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: insulin receptor substrate 2 HUGO:IRS2 HGNC:6126 ENTREZ:8660 UNIPROT:Q9Y4H2 GENECARDS:IRS2 REACTOME:57529 KEGG:8660 ATLASONC:GC_IRS2 WIKI:IRS2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="IRS2"/> <bbox w="90.0" h="25.0" x="14358.0" y="5203.5"/> <glyph class="unit of information" id="_bd0b9a54-ab91-4929-a77c-5839eb7e6890"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="14393.0" y="5198.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca3_s664_wca1_wca3_sa459" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re166(MAP:survival): Not known if P300 transcription complex mediates this trancription either it is CBP transcription complex PMID:17291450 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: teratocarcinoma-derived growth factor 1 HUGO:TDGF1 HGNC:11701 ENTREZ:6997 UNIPROT:P13385 GENECARDS:TDGF1 REACTOME:52798 KEGG:6997 ATLASONC:GC_TDGF1 WIKI:TDGF1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="CRIPTO-1*"/> <bbox w="90.0" h="25.0" x="14358.0" y="5245.5"/> <glyph class="unit of information" id="_7aefd95c-b28b-43fd-abee-5e726abfa29c"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="14393.0" y="5240.5"/> </glyph> </glyph> <glyph class="unspecified entity" id="wca1_s_wca3_s75_wca1_wca3_sa67" compartmentRef="wca1_wca3_c2_wca1_wca3_ca2"> <label text="Unknown kinase"/> <bbox w="70.0" h="25.0" x="14915.0" y="3602.5"/> </glyph> <glyph class="phenotype" id="wca1_s_wca3_s302_wca1_wca3_sa232" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Cell cycle or growth effect stimulate complex formation PMID:11972058 References_end</body> </html> </notes> <label text="Cell cycle pathway"/> <bbox w="80.0" h="30.0" x="13000.0" y="3389.0"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s21_wca1_wca4_sa14" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="AXIN2"/> <bbox w="90.0" h="25.0" x="15996.0" y="3662.5"/> <glyph class="unit of information" id="_22cfffb5-ac01-469f-b9ed-4874c01ab0c1"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="16031.0" y="3657.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s25_wca1_wca4_sa18" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca4_re7:(MAP:survival) PMD:23396279 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="FZD8"/> <bbox w="90.0" h="25.0" x="16052.0" y="5228.5"/> <glyph class="unit of information" id="_ed302097-4037-4c6b-afdc-e0b0b7407d2f"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="16087.0" y="5223.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s30_wca1_wca4_sa22" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca4_re12:(MAP:survival) PMID:23321667 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="WNT5A"/> <bbox w="90.0" h="25.0" x="16052.0" y="5186.5"/> <glyph class="unit of information" id="_ee72291b-e495-41cf-bdae-684ef91d1a1f"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="16087.0" y="5181.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s37_wca1_wca4_sa28" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca4_re11:(MAP:survival) PMID:23321667 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: WNT inhibitory factor 1 HUGO:WIF1 HGNC:18081 ENTREZ:11197 UNIPROT:Q9Y5W5 GENECARDS:WIF1 KEGG:11197 ATLASONC:WIF1ID44085ch12q14 WIKI:WIF1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="WIF1"/> <bbox w="90.0" h="25.0" x="16052.0" y="5151.5"/> <glyph class="unit of information" id="_005d032c-2a99-4964-bb95-fe8573bd52da"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="16087.0" y="5146.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s43_wca1_wca4_sa33" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca4_re18:(MAP:survival) PMID:22833265 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 7 "frizzled (Drosophila) homolog 7" "frizzled 7 seven transmembrane spanning receptor" "frizzled homolog 7 (Drosophila)" HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="FZD7"/> <bbox w="90.0" h="25.0" x="15996.0" y="3710.5"/> <glyph class="unit of information" id="_d2d9e41a-2288-4464-ad97-ba611700758c"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="16031.0" y="3705.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s50_wca1_wca4_sa39" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca4_re21:(MAP:survival) PMID:22833265 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 1 "frizzled (Drosophila) homolog 1" "frizzled 1 seven transmembrane spanning receptor" "frizzled homolog 1 (Drosophila)" HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="FZD1"/> <bbox w="90.0" h="25.0" x="15996.0" y="3801.5"/> <glyph class="unit of information" id="_7acdf3a7-28e5-4331-918e-104553c0e49a"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="16031.0" y="3796.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s57_wca1_wca4_sa45" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca4_re24:(MAP:survival) PMID:22833265 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 3 "frizzled (Drosophila) homolog 3" "frizzled 3 seven transmembrane spanning receptor" "frizzled homolog 3 (Drosophila)" HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="FZD3"/> <bbox w="90.0" h="25.0" x="15996.0" y="3900.5"/> <glyph class="unit of information" id="_62970b27-6d09-4eef-8de0-224c214f7a41"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="16031.0" y="3895.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s64_wca1_wca4_sa51" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca4_re27:(MAP:survival) PMID:22833265 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: frizzled family receptor 4 EVR1 "exudative vitreoretinopathy 1" "frizzled (Drosophila) homolog 4" "frizzled 4 seven transmembrane spanning receptor" "frizzled homolog 4 (Drosophila)" HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="FZD4"/> <bbox w="90.0" h="25.0" x="15996.0" y="3998.5"/> <glyph class="unit of information" id="_1d236c6e-4e84-44be-a308-576cd945ff48"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="16031.0" y="3993.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s71_wca1_wca4_sa58" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca4_re33:(MAP:survival) PMID:20439735 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) "dishevelled 1 (homologous to Drosophila dsh)" HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="DVL1"/> <bbox w="90.0" h="25.0" x="15854.0" y="4115.5"/> <glyph class="unit of information" id="_7b4f30ab-b2b1-4282-a601-ad9b453a4818"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="15889.0" y="4110.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s79_wca1_wca4_sa67" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: wingless-type MMTV integration site family, member 2B HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="WNT2B"/> <bbox w="90.0" h="25.0" x="15806.5" y="4290.5"/> <glyph class="unit of information" id="_1814331c-7526-453b-98d1-802f1109d776"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="15841.5" y="4285.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s89_wca1_wca4_sa77" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca4_re41:(MAP:survival) PMID:18362162 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dickkopf 3 homolog (Xenopus laevis) "dickkopf (Xenopus laevis) homolog 3" HUGO:DKK3 HGNC:2893 ENTREZ:27122 UNIPROT:Q9UBP4 GENECARDS:DKK3 KEGG:27122 ATLASONC:GC_DKK3 WIKI:DKK3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="DKK3"/> <bbox w="90.0" h="25.0" x="15806.5" y="4340.25"/> <glyph class="unit of information" id="_c3620a1d-d6ff-4f53-a06e-4e0354c163c1"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="15841.5" y="4335.25"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca4_s1_wca1_wca4_sa1" compartmentRef="wca1_wca4_c1_wca1_wca4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca4_re1:(MAP:survival) PMID:22699938 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: fermitin family member 2 KIND2 "kindlin-2" mig-2 UNC112B HUGO:FERMT2 HGNC:15767 ENTREZ:10979 UNIPROT:Q96AC1 GENECARDS:FERMT2 REACTOME:98372 KEGG:10979 ATLASONC:GC_FERMT2 WIKI:FERMT2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Kindlin2*"/> <bbox w="80.0" h="40.0" x="15697.0" y="3154.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca4_s2_wca1_wca4_sa2" compartmentRef="wca1_wca4_c1_wca1_wca4_ca1"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="15572.0" y="3153.0"/> <glyph class="state variable" id="_f3722a5e-61b8-4251-987f-da727afd816c"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="15599.404" y="3188.0"/> </glyph> <glyph class="state variable" id="_504a2369-202d-4652-8274-006b1676eef8"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="15638.882" y="3188.0"/> </glyph> <glyph class="state variable" id="_d59684ba-7026-4f63-b28c-432a29f36d5e"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="15639.5" y="3148.2148"/> </glyph> <glyph class="state variable" id="_08eafce4-fa1b-4258-bb85-1c3eb2e84e3c"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="15599.532" y="3148.0"/> </glyph> <glyph class="state variable" id="_8fd1108e-4dfb-404c-9376-1a689634b3c5"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="15559.992" y="3148.0"/> </glyph> <glyph class="state variable" id="_a90d27b4-c08a-40de-b0de-e5c0bb8ecf32"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="15559.5" y="3187.7224"/> </glyph> <glyph class="state variable" id="_45e1005c-2182-499f-8711-3c9d13885d65"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="15637.0" y="3148.2148"/> </glyph> <glyph class="state variable" id="_67f497c5-4c70-4f2c-9eb2-851c1c9e03c9"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="15637.0" y="3148.2148"/> </glyph> <glyph class="state variable" id="_eb2fcec0-1017-4fdc-b65d-59e0f7d54859"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15567.0" y="3168.0"/> </glyph> <glyph class="state variable" id="_95d72618-bc41-4f30-8d54-8a8054776489"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="15557.492" y="3148.0"/> </glyph> <glyph class="state variable" id="_cf5a9d7f-e615-4631-acc9-ee04ee5e02ea"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="15637.0" y="3148.2148"/> </glyph> <glyph class="state variable" id="_adc11f2e-df6f-4a70-84b7-a413c3f04c52"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15567.0" y="3159.7158"/> </glyph> <glyph class="state variable" id="_62d76534-9a07-4bdf-8d9f-2a8e62b6bf63"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="15637.0" y="3148.2148"/> </glyph> <glyph class="state variable" id="_694727c2-ed30-4514-9664-f58f43165991"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15567.0" y="3168.0"/> </glyph> <glyph class="state variable" id="_515262af-a1f9-4855-bc0a-6505da895654"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="15636.382" y="3188.0"/> </glyph> <glyph class="state variable" id="_3bbb6e4e-aed9-4131-85e6-2cdc8a7eedc9"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="15637.0" y="3148.2148"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca4_s72_wca1_wca4_sa59" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca4_re33:(MAP:survival) PMID:20439735 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) "dishevelled 1 (homologous to Drosophila dsh)" HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="DVL1"/> <bbox w="80.0" h="40.0" x="15999.0" y="4108.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca4_s73_wca1_wca4_sa60" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca4_re33:(MAP:survival) PMID:20439735 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: sirtuin 1 "sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)" "sirtuin (silent mating type information regulation 2 S. cerevisiae homolog) 1" HUGO:SIRT1 HGNC:14929 ENTREZ:23411 UNIPROT:Q96EB6 GENECARDS:SIRT1 KEGG:23411 ATLASONC:SIRT1ID44006ch10q21 WIKI:SIRT1 sirtuin 2 SIR2L "sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)" "sirtuin (silent mating type information regulation 2 S.cerevisiae homolog) 2" HUGO:SIRT2 HGNC:10886 ENTREZ:22933 UNIPROT:Q8IXJ6 GENECARDS:SIRT2 KEGG:22933 ATLASONC:GC_SIRT2 WIKI:SIRT2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="SIRT1_2*"/> <bbox w="80.0" h="40.0" x="15926.0" y="4195.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca4_s80_wca1_wca4_sa68" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: wingless-type MMTV integration site family member 2B "wingless-type MMTV integration site family member 13" XWNT2 "XWNT2 Xenopus homolog of" HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="WNT2B"/> <bbox w="80.0" h="40.0" x="15956.0" y="4283.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca4_s85_wca1_wca4_sa73" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: E2F transcription factor 1 HUGO:E2F1 HGNC:3113 ENTREZ:1869 UNIPROT:Q01094 GENECARDS:E2F1 REACTOME:89561 KEGG:1869 ATLASONC:E2F1ID40382ch20q11 WIKI:E2F1 RBBP3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G1_CC_PHASE MAP:dnarepair / MODULE:S_CC_PHASE MAP:cellcycle / MODULE:E2F1 MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17218262 References_end Identifiers_begin: E2F transcription factor 1 HUGO:E2F1 HGNC:3113 ENTREZ:1869 UNIPROT:Q01094 GENECARDS:E2F1 REACTOME:89561 KEGG:1869 ATLASONC:E2F1ID40382ch20q11 WIKI:E2F1 RBBP3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:dnarepair / MODULE:G1_CC_PHASE MAP:dnarepair / MODULE:S_CC_PHASE MAP:cellcycle / MODULE:E2F1 MAP:cellcycle / MODULE:APOPTOSIS_ENTRY MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17218262 References_end</body> </html> </notes> <label text="E2F1"/> <bbox w="80.0" h="40.0" x="16065.0" y="3597.0"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca4_s87_wca1_wca4_sa75" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end Identifiers_begin: axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="AXIN2"/> <bbox w="80.0" h="40.0" x="16165.0" y="3654.0"/> <glyph class="state variable" id="_e33d42af-38cb-4900-8b5d-96d63aa0c8fb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="16240.0" y="3649.0"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_s_wca4_s90_wca1_wca4_sa78" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: dickkopf 3 homolog (Xenopus laevis) HUGO:DKK3 HGNC:2893 ENTREZ:27122 UNIPROT:Q9UBP4 GENECARDS:DKK3 KEGG:27122 ATLASONC:GC_DKK3 WIKI:DKK3 "dickkopf (Xenopus laevis) homolog 3" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="DKK3"/> <bbox w="80.0" h="40.0" x="15956.0" y="4332.75"/> </glyph> <glyph class="macromolecule" id="wca1_s_wca4_s91_wca1_wca4_sa79" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca4_re41:(MAP:survival) PMID:18362162 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: musashi RNA-binding protein 1 "Musashi (Drosophila) homolog 1" "musashi homolog 1 (Drosophila)" HUGO:MSI1 HGNC:7330 ENTREZ:4440 UNIPROT:O43347 GENECARDS:MSI1 ATLASONC:GC_MSI1 WIKI:MSI1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MSI1"/> <bbox w="80.0" h="40.0" x="15782.0" y="4211.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca4_s86_wca1_wca4_sa74" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <label text="Cell cycle pathway"/> <bbox w="80.0" h="30.0" x="16114.0" y="3504.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca4_s77_wca1_wca4_sa65" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca4_re35:(MAP:survival) PMID:20439735 References_end</body> </html> </notes> <label text="Transcription of WNT-target genes"/> <bbox w="80.0" h="30.0" x="16341.0" y="4158.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca4_s82_wca1_wca4_sa70" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <label text="Sonic hedgehog pathway"/> <bbox w="80.0" h="30.0" x="16149.0" y="4351.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca4_s83_wca1_wca4_sa71" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <label text="Notch pathway"/> <bbox w="80.0" h="30.0" x="16149.0" y="4400.0"/> </glyph> <glyph class="phenotype" id="wca1_s_wca4_s84_wca1_wca4_sa72" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <label text="BMP pathway"/> <bbox w="80.0" h="30.0" x="16149.0" y="4450.0"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s20_wca1_wca4_sa13" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: axin 2 HUGO:AXIN2 HGNC:904 ENTREZ:8313 UNIPROT:Q9Y2T1 GENECARDS:AXIN2 KEGG:8313 ATLASONC:AXIN2ID456ch17q24 WIKI:AXIN2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="AXIN2"/> <bbox w="70.0" h="25.0" x="15868.0" y="3662.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s22_wca1_wca4_sa15" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 375 MIRN375 HUGO:MIR375 HGNC:31868 ENTREZ:494324 GENECARDS:MIR375 KEGG:494324 ATLASONC:GC_MIR375 WIKI:MIR375 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR375"/> <bbox w="70.0" h="25.0" x="15706.0" y="5228.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s24_wca1_wca4_sa17" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="FZD8"/> <bbox w="70.0" h="25.0" x="15946.0" y="5228.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s29_wca1_wca4_sa21" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="WNT5A"/> <bbox w="70.0" h="25.0" x="15946.0" y="5186.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s31_wca1_wca4_sa23" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: FTX transcript XIST regulator (non-protein coding) "mir-374a-545 cluster host gene (non-protein coding)" MIR374AHG NCRNA00182 "non-protein coding RNA 182" HUGO:FTX HGNC:37190 ENTREZ:100302692 GENECARDS:FTX KEGG:100302692 WIKI:FTX Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR374A*"/> <bbox w="70.0" h="25.0" x="15706.0" y="5194.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s36_wca1_wca4_sa27" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: WNT inhibitory factor 1 HUGO:WIF1 HGNC:18081 ENTREZ:11197 UNIPROT:Q9Y5W5 GENECARDS:WIF1 KEGG:11197 ATLASONC:WIF1ID44085ch12q14 WIKI:WIF1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="WIF1"/> <bbox w="70.0" h="25.0" x="15946.0" y="5151.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s42_wca1_wca4_sa32" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: frizzled family receptor 7 "frizzled (Drosophila) homolog 7" "frizzled 7 seven transmembrane spanning receptor" "frizzled homolog 7 (Drosophila)" HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="FZD7"/> <bbox w="70.0" h="25.0" x="15868.0" y="3710.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s44_wca1_wca4_sa34" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 23b MIRN23B HUGO:MIR23B HGNC:31606 ENTREZ:407011 GENECARDS:MIR23B KEGG:407011 ATLASONC:GC_MIR23B WIKI:MIR23B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR23B"/> <bbox w="70.0" h="25.0" x="15868.0" y="3758.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s49_wca1_wca4_sa38" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: frizzled family receptor 1 "frizzled (Drosophila) homolog 1" "frizzled 1 seven transmembrane spanning receptor" "frizzled homolog 1 (Drosophila)" HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="FZD1"/> <bbox w="70.0" h="25.0" x="15868.0" y="3801.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s51_wca1_wca4_sa40" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 204 MIRN204 HUGO:MIR204 HGNC:31582 ENTREZ:406987 GENECARDS:MIR204 KEGG:406987 ATLASONC:GC_MIR204 WIKI:MIR204 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR204"/> <bbox w="70.0" h="25.0" x="15868.0" y="3841.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s56_wca1_wca4_sa44" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: frizzled family receptor 3 "frizzled (Drosophila) homolog 3" "frizzled 3 seven transmembrane spanning receptor" "frizzled homolog 3 (Drosophila)" HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="FZD3"/> <bbox w="70.0" h="25.0" x="15868.0" y="3900.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s58_wca1_wca4_sa46" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 31 MIRN31 HUGO:MIR31 HGNC:31630 ENTREZ:407035 GENECARDS:MIR31 KEGG:407035 ATLASONC:GC_MIR31 WIKI:MIR31 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR31"/> <bbox w="70.0" h="25.0" x="15868.0" y="3939.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s63_wca1_wca4_sa50" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: frizzled family receptor 4 EVR1 "exudative vitreoretinopathy 1" "frizzled (Drosophila) homolog 4" "frizzled 4 seven transmembrane spanning receptor" "frizzled homolog 4 (Drosophila)" HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="FZD4"/> <bbox w="70.0" h="25.0" x="15868.0" y="3998.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s65_wca1_wca4_sa52" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 493 MIRN493 HUGO:MIR493 HGNC:32082 ENTREZ:574450 GENECARDS:MIR493 KEGG:574450 ATLASONC:GC_MIR493 WIKI:MIR493 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR493"/> <bbox w="70.0" h="25.0" x="15868.0" y="4037.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s70_wca1_wca4_sa57" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) "dishevelled 1 (homologous to Drosophila dsh)" HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="DVL*"/> <bbox w="70.0" h="25.0" x="15736.0" y="4115.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s78_wca1_wca4_sa66" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: wingless-type MMTV integration site family member 2B "wingless-type MMTV integration site family member 13" XWNT2 "XWNT2 Xenopus homolog of" HUGO:WNT2B HGNC:12781 ENTREZ:7482 UNIPROT:Q93097 GENECARDS:WNT2B REACTOME:67360 KEGG:7482 ATLASONC:GC_WNT2B WIKI:WNT2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="WNT2B"/> <bbox w="70.0" h="25.0" x="15677.0" y="4290.5"/> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s88_wca1_wca4_sa76" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca4_re41:(MAP:survival) PMID:18362162 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dickkopf 3 homolog (Xenopus laevis) "dickkopf (Xenopus laevis) homolog 3" HUGO:DKK3 HGNC:2893 ENTREZ:27122 UNIPROT:Q9UBP4 GENECARDS:DKK3 KEGG:27122 ATLASONC:GC_DKK3 WIKI:DKK3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="DKK3"/> <bbox w="70.0" h="25.0" x="15677.0" y="4340.25"/> </glyph> <glyph class="source and sink" id="wca1_s_wca4_s41_wca1_wca4_sa31" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <label text="degradation"/> <clone/> <bbox w="30.0" h="30.0" x="16224.0" y="5213.0"/> </glyph> <glyph class="source and sink" id="wca1_s_wca4_s41_wca1_wca4_sa56" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <label text="degradation"/> <clone/> <bbox w="30.0" h="30.0" x="16335.0" y="3883.0"/> </glyph> <glyph class="complex" id="wca1_s_wca4_s5_wca1_wca4_csa1" compartmentRef="wca1_wca4_c1_wca1_wca4_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Kindlin2*:_beta_-Catenin* Identifiers_end References_begin: s_wca4_re1:(MAP:survival) PMID:22699938 s_wca4_re2(MAP:survival): NLS has been found in KINDLIN2 PMID:22699938 References_end</body> </html> </notes> <label text="Kindlin2*:β-Catenin*"/> <bbox w="100.0" h="120.0" x="15627.0" y="3254.0"/> <glyph class="macromolecule" id="wca1_wca4_s9_wca1_wca4_sa3"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="15636.0" y="3266.5"/> <glyph class="state variable" id="_a1d6870a-21ba-4ad6-8e38-ce68e214d14c"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="15663.404" y="3301.5"/> </glyph> <glyph class="state variable" id="_faa379d1-4a36-49f6-8650-7c4570a300f3"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="15702.882" y="3301.5"/> </glyph> <glyph class="state variable" id="_8c6141e8-73fe-4e2e-a68f-a0fa07f49d9a"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="15703.5" y="3261.7148"/> </glyph> <glyph class="state variable" id="_253f7956-54d1-431b-b503-c1d3e00568d2"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="15663.532" y="3261.5"/> </glyph> <glyph class="state variable" id="_55d2e1b2-67bf-45a7-b680-7fcdb6d4ee51"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="15623.992" y="3261.5"/> </glyph> <glyph class="state variable" id="_5f3aa3a0-4db3-41d3-a83a-f2912b1501d8"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="15623.5" y="3301.2224"/> </glyph> <glyph class="state variable" id="_904636b8-c695-423c-bb0a-8c8209066f90"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="15701.0" y="3261.7148"/> </glyph> <glyph class="state variable" id="_9dca8f11-dad6-48b3-bf65-513bfb79c116"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="15701.0" y="3261.7148"/> </glyph> <glyph class="state variable" id="_f912d4b3-8d2d-41af-ba5a-6609139c0fce"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15631.0" y="3281.5"/> </glyph> <glyph class="state variable" id="_6bce5c4b-7d78-4562-a3c0-039275c510f4"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="15621.492" y="3261.5"/> </glyph> <glyph class="state variable" id="_fd3651fb-7ff7-4ee9-87a1-3291968388f3"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="15701.0" y="3261.7148"/> </glyph> <glyph class="state variable" id="_a01b7a1d-f027-4c26-ba17-7915e3a49062"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15631.0" y="3273.2158"/> </glyph> <glyph class="state variable" id="_c8382918-6307-48e0-804d-f983b270a53f"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="15701.0" y="3261.7148"/> </glyph> <glyph class="state variable" id="_c2ece9da-6384-47c3-a33c-8f51513d0430"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15631.0" y="3281.5"/> </glyph> <glyph class="state variable" id="_c8d72bd3-5b29-4d10-a4d2-10e2440d69d4"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="15700.382" y="3301.5"/> </glyph> <glyph class="state variable" id="_cfb427b8-24a1-4f90-b856-123989c3b67e"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="15701.0" y="3261.7148"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca4_s10_wca1_wca4_sa4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: fermitin family member 2 KIND2 "kindlin-2" mig-2 UNC112B HUGO:FERMT2 HGNC:15767 ENTREZ:10979 UNIPROT:Q96AC1 GENECARDS:FERMT2 REACTOME:98372 KEGG:10979 ATLASONC:GC_FERMT2 WIKI:FERMT2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Kindlin2*"/> <bbox w="80.0" h="40.0" x="15636.0" y="3308.5"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca4_s8_wca1_wca4_csa2" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Kindlin2*:_beta_-Catenin* Identifiers_end References_begin: s_wca4_re2(MAP:survival): NLS has been found in KINDLIN2 PMID:22699938 References_end</body> </html> </notes> <label text="Kindlin2*:β-Catenin*"/> <bbox w="100.0" h="120.0" x="15681.0" y="3462.0"/> <glyph class="macromolecule" id="wca1_wca4_s7_wca1_wca4_sa5"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="15690.0" y="3474.5"/> <glyph class="state variable" id="_b5fa575a-f93f-49be-b5aa-4a7deb397683"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="15717.404" y="3509.5"/> </glyph> <glyph class="state variable" id="_b416b051-f07b-4881-9b64-c54b0b170255"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="15756.882" y="3509.5"/> </glyph> <glyph class="state variable" id="_2280854e-dfd2-4b42-8cae-8719beb0604c"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="15757.5" y="3469.7148"/> </glyph> <glyph class="state variable" id="_862311c3-002c-421b-8363-9f137eacea47"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="15717.532" y="3469.5"/> </glyph> <glyph class="state variable" id="_68fd4fe1-4cd1-4ff3-88e3-4e62941fb8ce"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="15677.992" y="3469.5"/> </glyph> <glyph class="state variable" id="_43523335-e785-4e8f-b35e-17e73e5c0aad"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="15677.5" y="3509.2224"/> </glyph> <glyph class="state variable" id="_7e44e569-a0ec-40ca-aa3a-93be1bcef4d0"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="15755.0" y="3469.7148"/> </glyph> <glyph class="state variable" id="_4ec38258-dcbf-4f19-ba6a-45a004aef1b8"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="15755.0" y="3469.7148"/> </glyph> <glyph class="state variable" id="_3db3cac9-37b3-4db7-917b-f73b2070e3f5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15685.0" y="3489.5"/> </glyph> <glyph class="state variable" id="_82986289-0291-4853-af97-aef85e69fca0"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="15675.492" y="3469.5"/> </glyph> <glyph class="state variable" id="_74c2d374-ca45-43e3-b62a-1e2ebfac1046"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="15755.0" y="3469.7148"/> </glyph> <glyph class="state variable" id="_413b3329-d6ff-48d1-9792-1f804593a2e0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15685.0" y="3481.2158"/> </glyph> <glyph class="state variable" id="_1e81db9e-0aac-4d3d-b52e-e8faa22ab7b2"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="15755.0" y="3469.7148"/> </glyph> <glyph class="state variable" id="_e447204c-29bc-4486-a31c-3c0462499866"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15685.0" y="3489.5"/> </glyph> <glyph class="state variable" id="_a5b319d2-1305-4d7b-b9fb-555ca7e4f915"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="15754.382" y="3509.5"/> </glyph> <glyph class="state variable" id="_eb698aca-d43f-4cb1-94d2-c62765684826"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="15755.0" y="3469.7148"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca4_s6_wca1_wca4_sa6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: fermitin family member 2 KIND2 "kindlin-2" mig-2 UNC112B HUGO:FERMT2 HGNC:15767 ENTREZ:10979 UNIPROT:Q96AC1 GENECARDS:FERMT2 REACTOME:98372 KEGG:10979 ATLASONC:GC_FERMT2 WIKI:FERMT2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Kindlin2*"/> <bbox w="80.0" h="40.0" x="15690.0" y="3516.5"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca4_s13_wca1_wca4_csa3" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TCF4:WRE* Identifiers_end References_begin: s_wca4_re3:(MAP:survival) PMID:22699938 References_end</body> </html> </notes> <label text="TCF4:WRE*"/> <bbox w="100.0" h="120.0" x="15681.0" y="3607.0"/> <glyph class="macromolecule" id="wca1_wca4_s11_wca1_wca4_sa7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TCF4"/> <bbox w="80.0" h="40.0" x="15694.0" y="3623.0"/> </glyph> <glyph class="nucleic acid feature" id="wca1_wca4_s12_wca1_wca4_sa8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: WNT responsive element References_end</body> </html> </notes> <label text="WRE*"/> <bbox w="70.0" h="25.0" x="15700.0" y="3666.5"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca4_s19_wca1_wca4_csa4" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Kindlin2*:TCF4:WRE*:_beta_-Catenin* Identifiers_end References_begin: s_wca4_re3:(MAP:survival) PMID:22699938 s_wca4_re4(MAP:survival): PMID:22699938 E2F1 PMID:15766563 References_end</body> </html> </notes> <label text="Kindlin2*:TCF4:WRE*:β-Catenin*"/> <bbox w="183.0" h="127.0" x="15882.0" y="3459.0"/> <glyph class="macromolecule" id="wca1_wca4_s14_wca1_wca4_sa9"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="15896.0" y="3470.0"/> <glyph class="state variable" id="_8160d343-fbb1-403c-8744-d2b23c6d7b49"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="15923.404" y="3505.0"/> </glyph> <glyph class="state variable" id="_24699eff-2f7a-4ddf-81d3-8332815b4ea3"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="15962.882" y="3505.0"/> </glyph> <glyph class="state variable" id="_0b97d1c4-e7a1-47e7-92f0-28061e016f8d"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="15963.5" y="3465.2148"/> </glyph> <glyph class="state variable" id="_b144f48c-36e7-49e6-89a7-c19579ea5464"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="15923.532" y="3465.0"/> </glyph> <glyph class="state variable" id="_938ab252-9aa6-4054-866a-49fefed9cc15"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="15883.992" y="3465.0"/> </glyph> <glyph class="state variable" id="_c77882ba-83dd-4bfe-bd9f-bd9d0500580b"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="15883.5" y="3504.7224"/> </glyph> <glyph class="state variable" id="_3da43114-f524-42d0-a6da-444a452a417c"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="15961.0" y="3465.2148"/> </glyph> <glyph class="state variable" id="_aaacb9be-5671-4f7e-8738-68b9fa4c5f8e"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="15961.0" y="3465.2148"/> </glyph> <glyph class="state variable" id="_95a796d3-bf27-4317-b419-0a0406101470"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15891.0" y="3485.0"/> </glyph> <glyph class="state variable" id="_0316c540-4c35-4f34-b2e3-9c6041ff9abc"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="15881.492" y="3465.0"/> </glyph> <glyph class="state variable" id="_b88e3570-ae2a-465d-8656-abe846571918"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="15961.0" y="3465.2148"/> </glyph> <glyph class="state variable" id="_ee7204f9-446e-4a0a-af87-698dc9d38bde"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15891.0" y="3476.7158"/> </glyph> <glyph class="state variable" id="_356eae29-a697-41de-9628-84f414b0a007"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="15961.0" y="3465.2148"/> </glyph> <glyph class="state variable" id="_0fca8d53-10e4-439f-a36b-c7134e9a2f82"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="15891.0" y="3485.0"/> </glyph> <glyph class="state variable" id="_e3eec4f8-b8a9-4653-9310-07ae482589dd"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="15960.382" y="3505.0"/> </glyph> <glyph class="state variable" id="_8d8932a8-a429-4bc5-8328-e29db95313ff"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="15961.0" y="3465.2148"/> </glyph> </glyph> <glyph class="macromolecule" id="wca1_wca4_s15_wca1_wca4_sa10"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: fermitin family member 2 KIND2 "kindlin-2" mig-2 UNC112B HUGO:FERMT2 HGNC:15767 ENTREZ:10979 UNIPROT:Q96AC1 GENECARDS:FERMT2 REACTOME:98372 KEGG:10979 ATLASONC:GC_FERMT2 WIKI:FERMT2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="Kindlin2*"/> <bbox w="80.0" h="40.0" x="15896.0" y="3512.0"/> </glyph> <glyph class="macromolecule" id="wca1_wca4_s17_wca1_wca4_sa11"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="TCF4"/> <bbox w="80.0" h="40.0" x="15978.0" y="3475.0"/> </glyph> <glyph class="nucleic acid feature" id="wca1_wca4_s18_wca1_wca4_sa12"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: WNT responsive element References_end</body> </html> </notes> <label text="WRE*"/> <bbox w="70.0" h="25.0" x="15984.0" y="3518.5"/> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca4_s26_wca1_wca4_csa5" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FZD8:MIR375 Identifiers_end References_begin: s_wca4_re7:(MAP:survival) PMD:23396279 References_end</body> </html> </notes> <label text="FZD8:MIR375"/> <bbox w="100.0" h="84.0" x="16188.0" y="5085.0"/> <glyph class="nucleic acid feature" id="wca1_wca4_s28_wca1_wca4_sa19"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 375 MIRN375 HUGO:MIR375 HGNC:31868 ENTREZ:494324 GENECARDS:MIR375 KEGG:494324 ATLASONC:GC_MIR375 WIKI:MIR375 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR375"/> <bbox w="90.0" h="25.0" x="16194.0" y="5094.0"/> <glyph class="unit of information" id="_b08ee569-dce6-4fbe-8ea9-91b69015e418"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="16224.0" y="5089.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_wca4_s27_wca1_wca4_sa20"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: frizzled family receptor 8 HUGO:FZD8 HGNC:4046 ENTREZ:8325 UNIPROT:Q9H461 GENECARDS:FZD8 REACTOME:55180 KEGG:8325 ATLASONC:GC_FZD8 WIKI:FZD8 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="FZD8"/> <bbox w="90.0" h="25.0" x="16194.0" y="5122.0"/> <glyph class="unit of information" id="_ed19ee48-1cde-449f-b047-e7df6f4db2d2"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="16229.0" y="5117.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca4_s33_wca1_wca4_csa6" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MIR374A:WNT5A Identifiers_end References_begin: s_wca4_re12:(MAP:survival) PMID:23321667 References_end</body> </html> </notes> <label text="MIR374A:WNT5A"/> <bbox w="100.0" h="84.0" x="16188.0" y="4991.0"/> <glyph class="nucleic acid feature" id="wca1_wca4_s35_wca1_wca4_sa25"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: FTX transcript XIST regulator (non-protein coding) "mir-374a-545 cluster host gene (non-protein coding)" MIR374AHG NCRNA00182 "non-protein coding RNA 182" HUGO:FTX HGNC:37190 ENTREZ:100302692 GENECARDS:FTX KEGG:100302692 WIKI:FTX Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR374A"/> <bbox w="90.0" h="25.0" x="16196.0" y="4998.0"/> <glyph class="unit of information" id="_f40973e8-1ee1-4d91-8314-1bf028f499d8"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="16226.0" y="4993.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_wca4_s34_wca1_wca4_sa26"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: wingless-type MMTV integration site family member 5A HUGO:WNT5A HGNC:12784 ENTREZ:7474 UNIPROT:P41221 GENECARDS:WNT5A REACTOME:67364 KEGG:7474 ATLASONC:WNT5AID42825ch3p14 WIKI:WNT5A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="WNT5A"/> <bbox w="90.0" h="25.0" x="16196.0" y="5026.0"/> <glyph class="unit of information" id="_dd4d985f-8c51-4355-89e2-0d4c19b4b3f9"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="16231.0" y="5021.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca4_s38_wca1_wca4_csa7" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MIR374A:WIF1 Identifiers_end References_begin: s_wca4_re11:(MAP:survival) PMID:23321667 References_end</body> </html> </notes> <label text="MIR374A:WIF1"/> <bbox w="101.0" h="85.0" x="16068.0" y="4992.0"/> <glyph class="nucleic acid feature" id="wca1_wca4_s40_wca1_wca4_sa29"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: FTX transcript XIST regulator (non-protein coding) "mir-374a-545 cluster host gene (non-protein coding)" MIR374AHG NCRNA00182 "non-protein coding RNA 182" HUGO:FTX HGNC:37190 ENTREZ:100302692 GENECARDS:FTX KEGG:100302692 WIKI:FTX Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR374A"/> <bbox w="90.0" h="25.0" x="16074.75" y="5000.5"/> <glyph class="unit of information" id="_96b393ae-1bc7-41d7-807d-a03f0572e89c"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="16104.75" y="4995.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_wca4_s39_wca1_wca4_sa30"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: WNT inhibitory factor 1 HUGO:WIF1 HGNC:18081 ENTREZ:11197 UNIPROT:Q9Y5W5 GENECARDS:WIF1 KEGG:11197 ATLASONC:WIF1ID44085ch12q14 WIKI:WIF1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="WIF1"/> <bbox w="90.0" h="25.0" x="16074.75" y="5029.5"/> <glyph class="unit of information" id="_c3e20d47-e7f2-4adb-a8dd-a94e77841aa8"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="16109.75" y="5024.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca4_s46_wca1_wca4_csa8" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FZD7:MIR23B Identifiers_end References_begin: s_wca4_re18:(MAP:survival) PMID:22833265 References_end</body> </html> </notes> <label text="FZD7:MIR23B"/> <bbox w="100.0" h="91.0" x="16158.0" y="3704.0"/> <glyph class="nucleic acid feature" id="wca1_wca4_s48_wca1_wca4_sa36"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: frizzled family receptor 7 "frizzled (Drosophila) homolog 7" "frizzled 7 seven transmembrane spanning receptor" "frizzled homolog 7 (Drosophila)" HUGO:FZD7 HGNC:4045 ENTREZ:8324 UNIPROT:O75084 GENECARDS:FZD7 REACTOME:55178 KEGG:8324 ATLASONC:GC_FZD7 WIKI:FZD7 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="FZD7"/> <bbox w="90.0" h="25.0" x="16161.0" y="3718.0"/> <glyph class="unit of information" id="_d6c95621-076c-45b4-a696-1e799bdc4639"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="16196.0" y="3713.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_wca4_s47_wca1_wca4_sa37"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 23b MIRN23B HUGO:MIR23B HGNC:31606 ENTREZ:407011 GENECARDS:MIR23B KEGG:407011 ATLASONC:GC_MIR23B WIKI:MIR23B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR23B"/> <bbox w="90.0" h="25.0" x="16161.0" y="3746.0"/> <glyph class="unit of information" id="_11468a9c-9fde-4af8-a51e-0d531e05a0ea"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="16191.0" y="3741.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca4_s53_wca1_wca4_csa9" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FZD1:MIR204 Identifiers_end References_begin: s_wca4_re21:(MAP:survival) PMID:22833265 References_end</body> </html> </notes> <label text="FZD1:MIR204"/> <bbox w="99.0" h="89.0" x="16159.0" y="3801.0"/> <glyph class="nucleic acid feature" id="wca1_wca4_s55_wca1_wca4_sa42"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: frizzled family receptor 1 "frizzled (Drosophila) homolog 1" "frizzled 1 seven transmembrane spanning receptor" "frizzled homolog 1 (Drosophila)" HUGO:FZD1 HGNC:4038 ENTREZ:8321 UNIPROT:Q9UP38 GENECARDS:FZD1 REACTOME:55166 ATLASONC:GC_FZD1 WIKI:FZD1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="FZD1"/> <bbox w="90.0" h="25.0" x="16163.0" y="3812.0"/> <glyph class="unit of information" id="_d43b82c9-6ef0-464a-a1a4-fbb5e2b74955"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="16198.0" y="3807.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_wca4_s54_wca1_wca4_sa43"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 204 MIRN204 HUGO:MIR204 HGNC:31582 ENTREZ:406987 GENECARDS:MIR204 KEGG:406987 ATLASONC:GC_MIR204 WIKI:MIR204 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR204"/> <bbox w="90.0" h="25.0" x="16163.0" y="3839.0"/> <glyph class="unit of information" id="_bdb4b36e-4642-4a72-8aef-d871936696c6"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="16193.0" y="3834.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca4_s60_wca1_wca4_csa10" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FZD3:MIR31 Identifiers_end References_begin: s_wca4_re24:(MAP:survival) PMID:22833265 References_end</body> </html> </notes> <label text="FZD3:MIR31"/> <bbox w="100.0" h="81.0" x="16159.0" y="3898.0"/> <glyph class="nucleic acid feature" id="wca1_wca4_s62_wca1_wca4_sa48"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: frizzled family receptor 3 "frizzled (Drosophila) homolog 3" "frizzled 3 seven transmembrane spanning receptor" "frizzled homolog 3 (Drosophila)" HUGO:FZD3 HGNC:4041 ENTREZ:7976 UNIPROT:Q9NPG1 GENECARDS:FZD3 REACTOME:55170 KEGG:7976 ATLASONC:GC_FZD3 WIKI:FZD3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="FZD3"/> <bbox w="90.0" h="25.0" x="16162.0" y="3908.5"/> <glyph class="unit of information" id="_d33ef99e-0d42-4fd3-9f05-a1823b623830"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="16197.0" y="3903.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_wca4_s61_wca1_wca4_sa49"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 31 MIRN31 HUGO:MIR31 HGNC:31630 ENTREZ:407035 GENECARDS:MIR31 KEGG:407035 ATLASONC:GC_MIR31 WIKI:MIR31 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR31"/> <bbox w="90.0" h="25.0" x="16162.0" y="3935.5"/> <glyph class="unit of information" id="_37bde054-9444-4a32-a3eb-6b2bb9b5c510"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="16192.0" y="3930.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca4_s67_wca1_wca4_csa11" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FZD4:MIR493 Identifiers_end References_begin: s_wca4_re27:(MAP:survival) PMID:22833265 References_end</body> </html> </notes> <label text="FZD4:MIR493"/> <bbox w="96.0" h="82.0" x="16162.0" y="3994.0"/> <glyph class="nucleic acid feature" id="wca1_wca4_s69_wca1_wca4_sa54"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: frizzled family receptor 4 EVR1 "exudative vitreoretinopathy 1" "frizzled (Drosophila) homolog 4" "frizzled 4 seven transmembrane spanning receptor" "frizzled homolog 4 (Drosophila)" HUGO:FZD4 HGNC:4042 ENTREZ:8322 UNIPROT:Q9ULV1 GENECARDS:FZD4 REACTOME:55172 KEGG:8322 ATLASONC:GC_FZD4 WIKI:FZD4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="FZD4"/> <bbox w="90.0" h="25.0" x="16164.0" y="4006.5"/> <glyph class="unit of information" id="_4aec3ca6-4765-44b3-beda-ffb985c12c5f"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="16199.0" y="4001.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_wca4_s68_wca1_wca4_sa55"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 493 MIRN493 HUGO:MIR493 HGNC:32082 ENTREZ:574450 GENECARDS:MIR493 KEGG:574450 ATLASONC:GC_MIR493 WIKI:MIR493 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR493"/> <bbox w="90.0" h="25.0" x="16164.0" y="4033.5"/> <glyph class="unit of information" id="_2777d097-c060-4c31-a509-66934874dc39"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="16194.0" y="4028.5"/> </glyph> </glyph> </glyph> <glyph class="complex" id="wca1_s_wca4_s74_wca1_wca4_csa12" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:DVL1:SIRT1_2* Identifiers_end References_begin: s_wca4_re34:(MAP:survival) PMID:20439735 References_end</body> </html> </notes> <label text="DVL1:SIRT1_2*"/> <bbox w="100.0" h="120.0" x="16161.0" y="4112.0"/> <glyph class="macromolecule" id="wca1_wca4_s76_wca1_wca4_sa63"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: dishevelled dsh homolog 1 (Drosophila) "dishevelled 1 (homologous to Drosophila dsh)" HUGO:DVL1 HGNC:3084 ENTREZ:1855 UNIPROT:O14640 GENECARDS:DVL1 KEGG:1855 ATLASONC:DVL1ID463ch1p36 WIKI:DVL1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="DVL1"/> <bbox w="80.0" h="40.0" x="16172.25" y="4126.5"/> </glyph> <glyph class="macromolecule" id="wca1_wca4_s75_wca1_wca4_sa64"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: sirtuin 1 "sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae)" "sirtuin (silent mating type information regulation 2 S. cerevisiae homolog) 1" HUGO:SIRT1 HGNC:14929 ENTREZ:23411 UNIPROT:Q96EB6 GENECARDS:SIRT1 KEGG:23411 ATLASONC:SIRT1ID44006ch10q21 WIKI:SIRT1 sirtuin 2 SIR2L "sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae)" "sirtuin (silent mating type information regulation 2 S.cerevisiae homolog) 2" HUGO:SIRT2 HGNC:10886 ENTREZ:22933 UNIPROT:Q8IXJ6 GENECARDS:SIRT2 KEGG:22933 ATLASONC:GC_SIRT2 WIKI:SIRT2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="SIRT1_2*"/> <bbox w="80.0" h="40.0" x="16172.25" y="4168.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s23_wca1_wca4_sa16" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca4_re7:(MAP:survival) PMD:23396279 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 375 MIRN375 HUGO:MIR375 HGNC:31868 ENTREZ:494324 GENECARDS:MIR375 KEGG:494324 ATLASONC:GC_MIR375 WIKI:MIR375 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR375"/> <bbox w="90.0" h="25.0" x="15830.0" y="5228.5"/> <glyph class="unit of information" id="_d88c4b8f-7248-427d-8409-3c1d3b2ebad5"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="15860.0" y="5223.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s32_wca1_wca4_sa24" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca4_re11:(MAP:survival) PMID:23321667 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: FTX transcript XIST regulator (non-protein coding) "mir-374a-545 cluster host gene (non-protein coding)" MIR374AHG NCRNA00182 "non-protein coding RNA 182" HUGO:FTX HGNC:37190 ENTREZ:100302692 GENECARDS:FTX KEGG:100302692 WIKI:FTX Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR374A"/> <bbox w="90.0" h="25.0" x="15830.0" y="5194.5"/> <glyph class="unit of information" id="_eda290e8-3c32-4d41-b6e3-d05988b26f8e"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="15860.0" y="5189.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s45_wca1_wca4_sa35" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca4_re18:(MAP:survival) PMID:22833265 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 23b MIRN23B HUGO:MIR23B HGNC:31606 ENTREZ:407011 GENECARDS:MIR23B KEGG:407011 ATLASONC:GC_MIR23B WIKI:MIR23B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR23B"/> <bbox w="90.0" h="25.0" x="15996.0" y="3758.5"/> <glyph class="unit of information" id="_e92abd0a-2867-40b9-ac6c-0f5dfeaa1acf"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="16026.0" y="3753.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s52_wca1_wca4_sa41" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca4_re21:(MAP:survival) PMID:22833265 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 204 MIRN204 HUGO:MIR204 HGNC:31582 ENTREZ:406987 GENECARDS:MIR204 KEGG:406987 ATLASONC:GC_MIR204 WIKI:MIR204 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR204"/> <bbox w="90.0" h="25.0" x="15996.0" y="3841.5"/> <glyph class="unit of information" id="_5240ea6d-314c-4217-9484-7c933abc10fe"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="16026.0" y="3836.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s59_wca1_wca4_sa47" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca4_re24:(MAP:survival) PMID:22833265 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 31 MIRN31 HUGO:MIR31 HGNC:31630 ENTREZ:407035 GENECARDS:MIR31 KEGG:407035 ATLASONC:GC_MIR31 WIKI:MIR31 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR31"/> <bbox w="90.0" h="25.0" x="15996.0" y="3939.5"/> <glyph class="unit of information" id="_d49c89d6-b9e9-4896-9f3c-fcc390a2efac"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="16026.0" y="3934.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="wca1_s_wca4_s66_wca1_wca4_sa53" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca4_re27:(MAP:survival) PMID:22833265 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 493 MIRN493 HUGO:MIR493 HGNC:32082 ENTREZ:574450 GENECARDS:MIR493 KEGG:574450 ATLASONC:GC_MIR493 WIKI:MIR493 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <label text="MIR493"/> <bbox w="90.0" h="25.0" x="15996.0" y="4037.5"/> <glyph class="unit of information" id="_2da55a6f-fa82-458d-a8aa-3e27e314d85b"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="16026.0" y="4032.5"/> </glyph> </glyph> <glyph class="phenotype" id="wca1_s_wca4_s81_wca1_wca4_sa69" compartmentRef="wca1_wca4_c2_wca1_wca4_ca2"> <label text="WNT canonical pathway"/> <bbox w="80.0" h="30.0" x="16149.0" y="4287.0"/> </glyph> <glyph class="complex" id="wca1_s1327_wca1_wca3_csa32" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK2_alpha_:CK2_alpha_*:CK2_beta_* Identifiers_end</body> </html> </notes> <label text="(CK2)"/> <clone/> <bbox w="95.0" h="108.0" x="12987.0" y="3450.0"/> <glyph class="macromolecule" id="wca1_s1328_wca1_wca3_sa222"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 alpha 1 polypeptide HUGO:CSNK2A1 HGNC:2457 ENTREZ:1457 UNIPROT:P68400 GENECARDS:CSNK2A1 REACTOME:201673 KEGG:1457 ATLASONC:GC_CSNK2A1 WIKI:CSNK2A1 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 alpha 1 polypeptide HUGO:CSNK2A1 HGNC:2457 ENTREZ:1457 UNIPROT:P68400 GENECARDS:CSNK2A1 REACTOME:201673 KEGG:1457 ATLASONC:GC_CSNK2A1 WIKI:CSNK2A1 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2α*"/> <clone/> <bbox w="40.0" h="30.0" x="12991.0" y="3465.0"/> </glyph> <glyph class="macromolecule" id="wca1_s1329_wca1_wca3_sa223"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 alpha prime polypeptide HUGO:CSNK2A2 HGNC:2459 ENTREZ:1459 UNIPROT:P19784 GENECARDS:CSNK2A2 REACTOME:57879 KEGG:1459 ATLASONC:GC_CSNK2A2 WIKI:CSNK2A2 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 alpha prime polypeptide HUGO:CSNK2A2 HGNC:2459 ENTREZ:1459 UNIPROT:P19784 GENECARDS:CSNK2A2 REACTOME:57879 KEGG:1459 ATLASONC:GC_CSNK2A2 WIKI:CSNK2A2 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2α'*"/> <clone/> <bbox w="40.0" h="30.0" x="13035.0" y="3465.0"/> </glyph> <glyph class="macromolecule" id="wca1_s1330_wca1_wca3_sa224"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2β*"/> <clone/> <bbox w="40.0" h="30.0" x="12991.0" y="3500.0"/> </glyph> <glyph class="macromolecule" id="wca1_s1330_wca1_wca3_sa225"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2β*"/> <clone/> <bbox w="40.0" h="30.0" x="13035.0" y="3500.0"/> </glyph> </glyph> <glyph class="complex" id="wca1_s1327_wca1_wca3_csa42" compartmentRef="wca1_wca3_c1_wca1_wca3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CK2_alpha_:CK2_alpha_*:CK2_beta_* Identifiers_end</body> </html> </notes> <label text="(CK2)"/> <clone/> <bbox w="93.0" h="107.0" x="13137.0" y="3449.5"/> <glyph class="macromolecule" id="wca1_s1328_wca1_wca3_sa262"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 alpha 1 polypeptide HUGO:CSNK2A1 HGNC:2457 ENTREZ:1457 UNIPROT:P68400 GENECARDS:CSNK2A1 REACTOME:201673 KEGG:1457 ATLASONC:GC_CSNK2A1 WIKI:CSNK2A1 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 alpha 1 polypeptide HUGO:CSNK2A1 HGNC:2457 ENTREZ:1457 UNIPROT:P68400 GENECARDS:CSNK2A1 REACTOME:201673 KEGG:1457 ATLASONC:GC_CSNK2A1 WIKI:CSNK2A1 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2α*"/> <clone/> <bbox w="40.0" h="30.0" x="13142.0" y="3464.5"/> </glyph> <glyph class="macromolecule" id="wca1_s1329_wca1_wca3_sa263"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 alpha prime polypeptide HUGO:CSNK2A2 HGNC:2459 ENTREZ:1459 UNIPROT:P19784 GENECARDS:CSNK2A2 REACTOME:57879 KEGG:1459 ATLASONC:GC_CSNK2A2 WIKI:CSNK2A2 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 alpha prime polypeptide HUGO:CSNK2A2 HGNC:2459 ENTREZ:1459 UNIPROT:P19784 GENECARDS:CSNK2A2 REACTOME:57879 KEGG:1459 ATLASONC:GC_CSNK2A2 WIKI:CSNK2A2 casein kinase 2 alpha 3 polypeptide HUGO:CSNK2A3 HGNC:2458 ENTREZ:283106 UNIPROT:Q8NEV1 GENECARDS:CSNK2A3 KEGG:283106 WIKI:CSNK2A3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2α'*"/> <clone/> <bbox w="40.0" h="30.0" x="13183.0" y="3464.5"/> </glyph> <glyph class="macromolecule" id="wca1_s1330_wca1_wca3_sa264"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2β*"/> <clone/> <bbox w="40.0" h="30.0" x="13142.0" y="3499.5"/> </glyph> <glyph class="macromolecule" id="wca1_s1330_wca1_wca3_sa265"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end Identifiers_begin: casein kinase 2 beta polypeptide HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B HUGO:CSKN2B GENECARDS:CSKN2B WIKI:CSKN2B HUGO:CSNK2B HGNC:2460 ENTREZ:1460 UNIPROT:P67870 GENECARDS:CSNK2B REACTOME:57881 KEGG:1460 ATLASONC:GC_CSNK2B WIKI:CSNK2B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20976471 PMID:20558317 References_end</body> </html> </notes> <label text="CK2β*"/> <clone/> <bbox w="40.0" h="30.0" x="13185.0" y="3499.5"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s368_shh1_shh1_csa28" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GLI3-190*:SUFU:ULK3 Identifiers_end</body> </html> </notes> <label text="GLI3-190_SUFU_ULK3"/> <bbox w="188.0" h="136.0" x="18901.0" y="1430.0"/> <glyph class="macromolecule" id="shh1_shh1_s242_shh1_shh1_sa116"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 3 HUGO:GLI3 HGNC:4319 ENTREZ:2737 UNIPROT:P10071 GENECARDS:GLI3 KEGG:2737 ATLASONC:GC_GLI3 WIKI:GLI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI3-190*"/> <bbox w="165.0" h="41.0" x="18915.824" y="1496.4706"/> <glyph class="state variable" id="_95a2b113-7f6f-4423-afc7-3c5ec2406a7f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18942.834" y="1491.4706"/> </glyph> <glyph class="state variable" id="_9827af94-2252-41e4-91e9-331403a86bd4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18962.346" y="1491.4706"/> </glyph> <glyph class="state variable" id="_c10c0356-99d0-4222-a479-e77457d8bf2a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18975.809" y="1491.4706"/> </glyph> <glyph class="state variable" id="_3f3fa345-951d-455d-b05c-4c62d7d83b58"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19014.18" y="1532.4706"/> </glyph> <glyph class="state variable" id="_366512c6-334e-4af1-96bf-a8fb2add8f74"> <state value="P" variable="S860"/> <bbox w="35.0" h="10.0" x="18998.477" y="1491.4706"/> </glyph> <glyph class="state variable" id="_7bceea2c-a47e-47a0-ba29-088326f6701c"> <state value="P" variable="S907"/> <bbox w="35.0" h="10.0" x="18945.71" y="1532.4706"/> </glyph> <glyph class="state variable" id="_f069eeec-3d0c-48b5-82de-e2a6cf45daf0"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="18937.834" y="1491.4706"/> </glyph> <glyph class="state variable" id="_1c134889-8123-4f5b-9e24-3d5a1840bc80"> <state value="P" variable="S873"/> <bbox w="35.0" h="10.0" x="19063.324" y="1512.0359"/> </glyph> <glyph class="state variable" id="_ef36b306-75ac-4a06-94f3-00e2e1af82e8"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="18957.346" y="1491.4706"/> </glyph> <glyph class="state variable" id="_cbd399de-f27f-4dbb-bf18-56d7499dbe15"> <state value="P" variable="S849"/> <bbox w="35.0" h="10.0" x="18899.34" y="1491.4706"/> </glyph> <glyph class="state variable" id="_50f4a2e0-4b16-4b6b-8b98-90ae9c1bdb8c"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="18970.809" y="1491.4706"/> </glyph> <glyph class="state variable" id="_140cb40d-19c1-40af-a03a-5f344d733fb5"> <state value="P" variable="S868"/> <bbox w="35.0" h="10.0" x="19056.275" y="1491.4706"/> </glyph> <glyph class="state variable" id="_9517c372-7623-4059-b620-1fbf5ef55a7d"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="19009.18" y="1532.4706"/> </glyph> <glyph class="state variable" id="_7b02870f-bc18-4b12-8a2b-155c0cb8c9e9"> <state value="P" variable="S877"/> <bbox w="35.0" h="10.0" x="19062.049" y="1532.4706"/> </glyph> <glyph class="state variable" id="_6f5ee9d8-f8c3-488f-9bf4-ef1ab7d416eb"> <state value="P" variable="S880"/> <bbox w="35.0" h="10.0" x="19019.424" y="1532.4706"/> </glyph> <glyph class="state variable" id="_0ff9d382-10a7-4bea-85f4-bb4443118633"> <state value="P" variable="S903"/> <bbox w="35.0" h="10.0" x="18982.277" y="1532.4706"/> </glyph> <glyph class="state variable" id="_66fb155e-a7ef-475d-aa01-0f4c08ac3822"> <state value="P" variable="S910"/> <bbox w="35.0" h="10.0" x="18898.818" y="1532.4706"/> </glyph> <glyph class="state variable" id="_74aab8a4-8a1e-48c0-9c13-0b57714be35e"> <state value="P" variable="S852"/> <bbox w="35.0" h="10.0" x="18979.24" y="1491.4706"/> </glyph> <glyph class="state variable" id="_e7b0bf07-d406-4d19-8787-bb47747e5b65"> <state value="P" variable="S1006"/> <bbox w="40.0" h="10.0" x="18895.824" y="1506.4822"/> </glyph> <glyph class="state variable" id="_35a4d549-3a08-41aa-b985-76e35844778f"> <state value="P" variable="S865"/> <bbox w="35.0" h="10.0" x="19015.781" y="1491.4706"/> </glyph> <glyph class="state variable" id="_e727a824-743b-41e7-99f7-8f4b1e43fa20"> <state value="P" variable="S980"/> <bbox w="35.0" h="10.0" x="18898.324" y="1514.2017"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s370_shh1_shh1_sa208"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <bbox w="80.0" h="40.0" x="18920.25" y="1450.0"/> <glyph class="state variable" id="_66049493-59e0-4e25-bca0-5157d04b26bc"> <state value="" variable="K257"/> <bbox w="30.0" h="10.0" x="18905.742" y="1445.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s371_shh1_shh1_sa209"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Unc-51-like kinase 3 HUGO:ULK3 HGNC:19703 ENTREZ:25989 UNIPROT:Q6PHR2 GENECARDS:ULK3 ATLASONC:GC_ULK3 WIKI:ULK3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Unc-51-like kinase PMID:20643644 PMID:19878745 References_end</body> </html> </notes> <label text="ULK3"/> <bbox w="80.0" h="40.0" x="19003.75" y="1452.0"/> <glyph class="state variable" id="_9970c3f3-be60-479c-ac1a-8b311136e2ce"> <state value="" variable="S384"/> <bbox w="30.0" h="10.0" x="19068.13" y="1487.0"/> </glyph> <glyph class="state variable" id="_e9c05698-eac9-47f4-a086-b92a7bcdb1ef"> <state value="" variable="S464"/> <bbox w="30.0" h="10.0" x="18988.75" y="1486.7223"/> </glyph> <glyph class="state variable" id="_438eb9a2-1576-4a1e-8e79-8b51a786090d"> <state value="" variable="S300"/> <bbox w="30.0" h="10.0" x="18989.242" y="1447.0"/> </glyph> <glyph class="state variable" id="_fdf36c44-37c8-42d5-8312-aae10d127760"> <state value="" variable="S350"/> <bbox w="30.0" h="10.0" x="19068.75" y="1447.2147"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s358_shh1_shh1_csa24" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AKAP*:PKA* Identifiers_end References_begin: s_shh1_re52:(MAP:survival) PMID:20016067 s_shh1_re49(MAP:survival): PMID:20016067 the PTC receptor itself does not trigger the activation of PKA but the withdrawal of the SHH ligand does PMID:16537363 References_end</body> </html> </notes> <label text="PKA_AKAP"/> <bbox w="100.0" h="120.0" x="19144.0" y="885.0"/> <glyph class="macromolecule" id="shh1_shh1_s359_shh1_shh1_sa190"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: A kinase (PRKA) anchor protein 1 HUGO:AKAP1 HGNC:367 ENTREZ:8165 UNIPROT:Q92667 GENECARDS:AKAP1 REACTOME:49858 KEGG:8165 ATLASONC:GC_AKAP1 WIKI:AKAP1 A kinase (PRKA) anchor protein 2 HUGO:AKAP2 HGNC:372 ENTREZ:11217 UNIPROT:Q9Y2D5 GENECARDS:AKAP2 KEGG:11217 WIKI:AKAP2 A kinase (PRKA) anchor protein 3 HUGO:AKAP3 HGNC:373 ENTREZ:10566 UNIPROT:O75969 GENECARDS:AKAP3 KEGG:10566 ATLASONC:GC_AKAP3 WIKI:AKAP3 A kinase (PRKA) anchor protein 4 HUGO:AKAP4 HGNC:374 ENTREZ:8852 UNIPROT:Q5JQC9 GENECARDS:AKAP4 KEGG:8852 ATLASONC:GC_AKAP4 WIKI:AKAP4 A kinase (PRKA) anchor protein 5 HUGO:AKAP5 HGNC:375 ENTREZ:9495 UNIPROT:P24588 GENECARDS:AKAP5 REACTOME:381620 KEGG:9495 ATLASONC:GC_AKAP5 WIKI:AKAP5 A kinase (PRKA) anchor protein 6 HUGO:AKAP6 HGNC:376 ENTREZ:9472 UNIPROT:Q13023 GENECARDS:AKAP6 KEGG:9472 ATLASONC:GC_AKAP6 WIKI:AKAP6 A kinase (PRKA) anchor protein 7 HUGO:AKAP7 HGNC:377 ENTREZ:9465 UNIPROT:O43687 GENECARDS:AKAP7 KEGG:9465 ATLASONC:GC_AKAP7 WIKI:AKAP7 A kinase (PRKA) anchor protein 8 HUGO:AKAP8 HGNC:378 ENTREZ:10270 UNIPROT:O43823 GENECARDS:AKAP8 KEGG:10270 ATLASONC:GC_AKAP8 WIKI:AKAP8 A kinase (PRKA) anchor protein 9 HUGO:AKAP9 HGNC:379 ENTREZ:10142 UNIPROT:Q99996 GENECARDS:AKAP9 REACTOME:49844 KEGG:10142 ATLASONC:AKAP9ID42999ch7q21 WIKI:AKAP9 A kinase (PRKA) anchor protein 10 HUGO:AKAP10 HGNC:368 ENTREZ:11216 UNIPROT:O43572 GENECARDS:AKAP10 REACTOME:49822 KEGG:11216 ATLASONC:GC_AKAP10 WIKI:AKAP10 A kinase (PRKA) anchor protein 11 HUGOAKAP11 HGNC:369 ENTREZ:11215 UNIPROT:Q9UKA4 A kinase (PRKA) anchor protein 12 HUGO:AKAP12 HGNC:370 ENTREZ:9590 UNIPROT:Q02952 GENECARDS:AKAP12 KEGG:9590 ATLASONC:AKAP12ID607ch6q25 WIKI:AKAP12 A kinase (PRKA) anchor protein 13 HUGO:AKA13 GENECARDS:AKA13 WIKI:AKA13 A kinase (PRKA) anchor protein 14 HUGO:AKAP14 HGNC:24061 ENTREZ:158798 UNIPROT:Q86UN6 GENECARDS:AKAP14 KEGG:158798 WIKI:AKAP14 A kinase (PRKA) anchor protein 17 HUGO:AKAP17A HGNC:18783 ENTREZ:8227 UNIPROT:Q02040 GENECARDS:AKAP17A KEGG:8227 WIKI:AKAP17A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20016067 A kinase (PRKA) anchor protein References_end</body> </html> </notes> <label text="AKAP*"/> <bbox w="80.0" h="40.0" x="19153.0" y="942.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s360_shh1_shh1_sa191"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Protein kinase cAMP-depenedent catalytic alpha HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA Protein kinase cAMP-depenedent catalytic beta HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB Protein kinase cAMP-depenedent catalytic gamma HUGOPRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20027184 References_end</body> </html> </notes> <label text="PKA*"/> <bbox w="80.0" h="40.0" x="19152.5" y="896.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s306_shh1_shh1_csa21" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GLI3-190*:KIF7:SUFU:ULK3 Identifiers_end References_begin: s_shh1_re37(MAP:survival): PMID:20956384 PMID:19592253 s_shh1_re39(MAP:survival): PMID:21209912 PMID:19549984 References_end</body> </html> </notes> <label text="SUFU_Gli3"/> <bbox w="206.0" h="178.0" x="18215.0" y="559.0"/> <glyph class="macromolecule" id="shh1_shh1_s340_shh1_shh1_sa161"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 3 HUGO:GLI3 HGNC:4319 ENTREZ:2737 UNIPROT:P10071 GENECARDS:GLI3 KEGG:2737 ATLASONC:GC_GLI3 WIKI:GLI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI3-190*"/> <bbox w="165.0" h="41.0" x="18237.75" y="617.0"/> <glyph class="state variable" id="_48b5e593-e18d-410d-aa45-fc3fdc268d70"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18264.76" y="612.0"/> </glyph> <glyph class="state variable" id="_b2d31d12-176e-45a7-a218-ef5761c6689f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18284.271" y="612.0"/> </glyph> <glyph class="state variable" id="_0a0b8f82-7b0d-4441-a798-8f999126f445"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18297.734" y="612.0"/> </glyph> <glyph class="state variable" id="_885a63f3-8c84-402c-9c63-c88c4b552fe0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18336.105" y="653.0"/> </glyph> <glyph class="state variable" id="_f6e3249f-f6d0-408e-966a-9e131b556efa"> <state value="" variable="S860"/> <bbox w="30.0" h="10.0" x="18322.902" y="612.0"/> </glyph> <glyph class="state variable" id="_85a46c7e-8e7d-4330-a19a-3ebdd74daffb"> <state value="" variable="S907"/> <bbox w="30.0" h="10.0" x="18270.137" y="653.0"/> </glyph> <glyph class="state variable" id="_41a97dc7-b18f-45be-a29d-3efdedfa1952"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18264.76" y="612.0"/> </glyph> <glyph class="state variable" id="_9c166b8b-18bd-4bcc-bc52-a8b198a52840"> <state value="" variable="S873"/> <bbox w="30.0" h="10.0" x="18387.75" y="632.5653"/> </glyph> <glyph class="state variable" id="_7defca4d-71ca-4605-8816-5fe8df5de94e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18284.271" y="612.0"/> </glyph> <glyph class="state variable" id="_50838be7-ac77-4c15-80d3-be90627fbecb"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="18223.766" y="612.0"/> </glyph> <glyph class="state variable" id="_bb07481a-285b-4458-b7d6-80c97df7ec38"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18297.734" y="612.0"/> </glyph> <glyph class="state variable" id="_142917fd-c7e4-4e73-a08f-ec40fe432d3f"> <state value="" variable="S868"/> <bbox w="30.0" h="10.0" x="18380.701" y="612.0"/> </glyph> <glyph class="state variable" id="_ec5913f7-3397-415a-812d-aeff80842290"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18336.105" y="653.0"/> </glyph> <glyph class="state variable" id="_46abb253-aeb8-4436-ba77-1c167e84f5e5"> <state value="" variable="S877"/> <bbox w="30.0" h="10.0" x="18386.475" y="653.0"/> </glyph> <glyph class="state variable" id="_08abf67c-109d-42eb-8f47-976f2ed0c55e"> <state value="" variable="S880"/> <bbox w="30.0" h="10.0" x="18343.85" y="653.0"/> </glyph> <glyph class="state variable" id="_ba1fae5a-ef67-4697-83eb-a7707278c62d"> <state value="" variable="S903"/> <bbox w="30.0" h="10.0" x="18306.703" y="653.0"/> </glyph> <glyph class="state variable" id="_88096aa4-2f3f-457a-9323-45c07883e7f9"> <state value="" variable="S910"/> <bbox w="30.0" h="10.0" x="18223.244" y="653.0"/> </glyph> <glyph class="state variable" id="_5e47c579-12cb-4d85-aeed-d79c642e5c16"> <state value="" variable="S852"/> <bbox w="30.0" h="10.0" x="18303.666" y="612.0"/> </glyph> <glyph class="state variable" id="_8cc2c550-569a-43ec-88c7-e5a9c38f8991"> <state value="" variable="S1006"/> <bbox w="35.0" h="10.0" x="18220.25" y="627.0116"/> </glyph> <glyph class="state variable" id="_8f01f0e5-60fb-447a-8dbe-743b2f9951f2"> <state value="" variable="S865"/> <bbox w="30.0" h="10.0" x="18340.207" y="612.0"/> </glyph> <glyph class="state variable" id="_f23c7900-463a-4fde-8efd-8881173c7246"> <state value="" variable="S980"/> <bbox w="30.0" h="10.0" x="18222.75" y="634.7311"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s341_shh1_shh1_sa162"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <bbox w="80.0" h="40.0" x="18238.5" y="569.0"/> <glyph class="state variable" id="_1960bc16-b0f6-438b-8c0e-905401ada106"> <state value="" variable="K257"/> <bbox w="30.0" h="10.0" x="18223.992" y="564.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s342_shh1_shh1_sa176"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Kinesin family member 7 HUGO:KIF7 HGNC:30497 ENTREZ:374654 UNIPROT:Q2M1P5 GENECARDS:KIF7 KEGG:374654 WIKI:KIF7 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19666503 PMID:19906571 PMID:19592253 PMID:19549984 References_end</body> </html> </notes> <label text="KIF7"/> <bbox w="80.0" h="40.0" x="18281.5" y="667.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s343_shh1_shh1_sa182"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Unc-51-like kinase 3 HUGO:ULK3 HGNC:19703 ENTREZ:25989 UNIPROT:Q6PHR2 GENECARDS:ULK3 ATLASONC:GC_ULK3 WIKI:ULK3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Unc-51-like kinase PMID:20643644 PMID:19878745 References_end</body> </html> </notes> <label text="ULK3"/> <bbox w="80.0" h="40.0" x="18322.5" y="570.0"/> <glyph class="state variable" id="_0532ec17-b469-47cc-b59d-ba756cde8d60"> <state value="" variable="S384"/> <bbox w="30.0" h="10.0" x="18386.88" y="605.0"/> </glyph> <glyph class="state variable" id="_360dbd51-3a65-4ea0-bd62-3495213b791e"> <state value="" variable="S464"/> <bbox w="30.0" h="10.0" x="18307.5" y="604.7223"/> </glyph> <glyph class="state variable" id="_d9e8724f-6269-428e-add0-a0ca74ead59b"> <state value="" variable="S300"/> <bbox w="30.0" h="10.0" x="18307.992" y="565.0"/> </glyph> <glyph class="state variable" id="_e7d1f40a-6c81-4efa-8776-f36f82d1035b"> <state value="" variable="S350"/> <bbox w="30.0" h="10.0" x="18387.5" y="565.2148"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s303_shh1_shh1_csa20" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GLI2-185*:KIF7:SUFU:ULK3 Identifiers_end References_begin: s_shh1_re36(MAP:survival): PMID:20956384 PMID:19592253 PMID:0643644 s_shh1_re38(MAP:survival): PMID:21209912 PMID:19549984 References_end</body> </html> </notes> <label text="SUFU_Gli2"/> <bbox w="210.0" h="170.0" x="18208.0" y="385.0"/> <glyph class="macromolecule" id="shh1_shh1_s311_shh1_shh1_sa159"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 2 HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Glioma-associated oncogene family zinc finger PMID:18497536 PMID:17845852 PMID:11001584 References_end</body> </html> </notes> <label text="GLI2-185*"/> <bbox w="165.0" h="39.0" x="18231.75" y="443.0"/> <glyph class="state variable" id="_1b146db1-91aa-49ea-87ef-007be2114058"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18281.982" y="438.0"/> </glyph> <glyph class="state variable" id="_e0a49a56-f5ea-4223-ac15-7b962e812faf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18323.479" y="438.0"/> </glyph> <glyph class="state variable" id="_ce7fa6c9-7352-4a9d-809c-8c677c0b8202"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18330.105" y="477.0"/> </glyph> <glyph class="state variable" id="_18ee472c-a163-4b85-80ff-424fac5e8a7f"> <state value="" variable="S801"/> <bbox w="30.0" h="10.0" x="18285.156" y="438.0"/> </glyph> <glyph class="state variable" id="_cd404b4a-b214-4e24-b1d8-95341303427f"> <state value="" variable="K757"/> <bbox w="30.0" h="10.0" x="18216.75" y="450.12466"/> </glyph> <glyph class="state variable" id="_2f07d9b4-0772-419a-b8b5-5ad7fc2f0384"> <state value="" variable="S956"/> <bbox w="30.0" h="10.0" x="18216.75" y="476.72925"/> </glyph> <glyph class="state variable" id="_3e47920f-1b11-476e-a3e6-77158bd53a15"> <state value="" variable="S817"/> <bbox w="30.0" h="10.0" x="18380.475" y="477.0"/> </glyph> <glyph class="state variable" id="_101d554b-1cde-4a83-85f8-851b1dae8db5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18309.25" y="438.0"/> </glyph> <glyph class="state variable" id="_d56724fb-020d-404d-8c80-fcb2c5a5dd33"> <state value="" variable="S847"/> <bbox w="30.0" h="10.0" x="18267.97" y="477.0"/> </glyph> <glyph class="state variable" id="_df7d07f4-41f3-46c8-923e-56096e388d0d"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="18216.75" y="457.46893"/> </glyph> <glyph class="state variable" id="_d675ed8c-e8cc-4f3e-bef2-ca68c2963e51"> <state value="" variable="S789"/> <bbox w="30.0" h="10.0" x="18216.75" y="449.6754"/> </glyph> <glyph class="state variable" id="_1059c593-67a7-42c1-b445-8c716fd12330"> <state value="" variable="S1011"/> <bbox w="35.0" h="10.0" x="18214.25" y="464.36295"/> </glyph> <glyph class="state variable" id="_8619c14c-cb9e-4050-b2d5-a6b37ad85bae"> <state value="" variable="S805"/> <bbox w="30.0" h="10.0" x="18320.385" y="438.0"/> </glyph> <glyph class="state variable" id="_35389a33-2f72-4d6b-9289-2e98eb22b8bc"> <state value="" variable="S820"/> <bbox w="30.0" h="10.0" x="18345.139" y="477.0"/> </glyph> <glyph class="state variable" id="_84b58877-fc3b-4f9e-a649-0895e3ba85c5"> <state value="" variable="S813"/> <bbox w="30.0" h="10.0" x="18381.75" y="457.5621"/> </glyph> <glyph class="state variable" id="_64ec156e-a30a-426d-a8c6-43ff807d6b98"> <state value="" variable="S850"/> <bbox w="30.0" h="10.0" x="18216.75" y="475.9748"/> </glyph> <glyph class="state variable" id="_882f03ad-b30d-4bcc-bb85-09962d00d8e6"> <state value="" variable="S844"/> <bbox w="30.0" h="10.0" x="18294.096" y="477.0"/> </glyph> <glyph class="state variable" id="_bda4c1f4-bdab-440a-aaed-e92bc9295b2e"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="18217.766" y="438.0"/> </glyph> <glyph class="state variable" id="_6f81b625-9c9b-4281-a245-fc9d0a4b6bd1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18330.105" y="477.0"/> </glyph> <glyph class="state variable" id="_44517517-b134-4895-b049-aed7353bb99e"> <state value="" variable="S808"/> <bbox w="30.0" h="10.0" x="18380.994" y="438.0"/> </glyph> <glyph class="state variable" id="_c0466101-9dcc-44b1-b82b-0d2f36d0309c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18270.49" y="438.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s312_shh1_shh1_sa160"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <bbox w="80.0" h="40.0" x="18230.5" y="397.0"/> <glyph class="state variable" id="_9504cfa2-39cc-47a0-b5ab-f229b191c82b"> <state value="" variable="K257"/> <bbox w="30.0" h="10.0" x="18215.992" y="392.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s323_shh1_shh1_sa175"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Kinesin family member 7 HUGO:KIF7 HGNC:30497 ENTREZ:374654 UNIPROT:Q2M1P5 GENECARDS:KIF7 KEGG:374654 WIKI:KIF7 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19666503 PMID:19906571 PMID:19592253 PMID:19549984 References_end</body> </html> </notes> <label text="KIF7"/> <bbox w="80.0" h="40.0" x="18268.5" y="489.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s328_shh1_shh1_sa181"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Unc-51-like kinase 3 HUGO:ULK3 HGNC:19703 ENTREZ:25989 UNIPROT:Q6PHR2 GENECARDS:ULK3 ATLASONC:GC_ULK3 WIKI:ULK3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Unc-51-like kinase PMID:20643644 PMID:19878745 References_end</body> </html> </notes> <label text="ULK3"/> <bbox w="80.0" h="40.0" x="18314.5" y="398.0"/> <glyph class="state variable" id="_62fef0bb-0326-4351-b96a-027b2d272749"> <state value="" variable="S384"/> <bbox w="30.0" h="10.0" x="18378.88" y="433.0"/> </glyph> <glyph class="state variable" id="_efbcf333-0b21-406c-a754-2795994dfd41"> <state value="" variable="S464"/> <bbox w="30.0" h="10.0" x="18299.5" y="432.7223"/> </glyph> <glyph class="state variable" id="_0d3d5dd6-6440-4ad2-aeb1-dc0396d5c8f3"> <state value="" variable="S300"/> <bbox w="30.0" h="10.0" x="18299.992" y="393.0"/> </glyph> <glyph class="state variable" id="_d4d0efd0-5789-42b1-b69d-ce2ce7a7a271"> <state value="" variable="S350"/> <bbox w="30.0" h="10.0" x="18379.5" y="393.21478"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s296_shh1_shh1_csa19" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:KIF3A:KIF3B:SMO:_beta_-Arrestin2* Identifiers_end References_begin: s_shh1_re35(MAP:survival): PMID:18497258 PMID:11449277 PMID:20375059 Rad23 negatively regulates SHH signaling but how exactly is unknown. Recently it was shown to be associated with Smo trafficing into cilium References_end</body> </html> </notes> <label text="b-arrestin_SMO_ KIF3A"/> <bbox w="115.0" h="234.0" x="19203.0" y="429.0"/> <glyph class="macromolecule" id="shh1_shh1_s292_shh1_shh1_sa154"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="19218.5" y="447.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s293_shh1_shh1_sa155"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Smoothened HUGO:SMO HGNC:11119 ENTREZ:6608 UNIPROT:Q99835 GENECARDS:SMO REACTOME:64670 KEGG:6608 ATLASONC:GC_SMO WIKI:SMO Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18820483 PMID:17641202 Smoothened homologue (Drosophila) References_end</body> </html> </notes> <label text="SMO"/> <bbox w="80.0" h="40.0" x="19218.5" y="497.0"/> <glyph class="state variable" id="_df676f7c-e508-4f2f-9365-6024fec24a04"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19293.5" y="492.0"/> </glyph> <glyph class="state variable" id="_885a4b5d-ce25-415b-a95e-450808c3c692"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="19291.0" y="492.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s295_shh1_shh1_sa156"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Kinesin family member 3A HUGO:KIF3A HGNC:6319 ENTREZ:11127 UNIPROT:Q9Y496 GENECARDS:KIF3A REACTOME:58019 KEGG:11127 WIKI:KIF3A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11208056 PMID:14603322 References_end Identifiers_begin: Kinesin family member 3A HUGO:KIF3A HGNC:6319 ENTREZ:11127 UNIPROT:Q9Y496 GENECARDS:KIF3A REACTOME:58019 KEGG:11127 WIKI:KIF3A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11208056 PMID:14603322 References_end</body> </html> </notes> <label text="KIF3A"/> <bbox w="80.0" h="40.0" x="19218.5" y="544.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s542_shh1_shh1_sa311"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Kinesin family member 3B HUGO:KIF3B HGNC:6320 ENTREZ:9371 UNIPROT:O15066 GENECARDS:KIF3B REACTOME:58021 KEGG:9371 ATLASONC:GC_KIF3B WIKI:KIF3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11208056 PMID:14603322 References_end Identifiers_begin: Kinesin family member 3B HUGO:KIF3B HGNC:6320 ENTREZ:9371 UNIPROT:O15066 GENECARDS:KIF3B REACTOME:58021 KEGG:9371 ATLASONC:GC_KIF3B WIKI:KIF3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11208056 PMID:14603322 References_end</body> </html> </notes> <label text="KIF3B"/> <bbox w="80.0" h="40.0" x="19222.5" y="588.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s291_shh1_shh1_csa18" compartmentRef="shh1_shh1_c5_shh1_shh1_ca5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:KIF3A:KIF3B:SMO:_beta_-Arrestin2* Identifiers_end References_begin: s_shh1_re33:(MAP:survival) PMID:18497258 s_shh1_re35(MAP:survival): PMID:18497258 PMID:11449277 PMID:20375059 Rad23 negatively regulates SHH signaling but how exactly is unknown. Recently it was shown to be associated with Smo trafficing into cilium References_end</body> </html> </notes> <label text="b-arrestin_SMO_ KIF3A"/> <bbox w="111.0" h="205.0" x="18859.0" y="223.0"/> <glyph class="macromolecule" id="shh1_shh1_s297_shh1_shh1_sa150"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="18874.5" y="231.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s298_shh1_shh1_sa151"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Smoothened HUGO:SMO HGNC:11119 ENTREZ:6608 UNIPROT:Q99835 GENECARDS:SMO REACTOME:64670 KEGG:6608 ATLASONC:GC_SMO WIKI:SMO Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18820483 PMID:17641202 Smoothened homologue (Drosophila) References_end</body> </html> </notes> <label text="SMO"/> <bbox w="80.0" h="40.0" x="18874.5" y="275.0"/> <glyph class="state variable" id="_946e8cad-da28-458f-9313-87b06294c1b2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18949.5" y="270.0"/> </glyph> <glyph class="state variable" id="_1460ed1b-c0fc-49cc-ae45-c4875e61f58e"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="18947.0" y="270.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s299_shh1_shh1_sa153"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Kinesin family member 3A HUGO:KIF3A HGNC:6319 ENTREZ:11127 UNIPROT:Q9Y496 GENECARDS:KIF3A REACTOME:58019 KEGG:11127 WIKI:KIF3A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11208056 PMID:14603322 References_end Identifiers_begin: Kinesin family member 3A HUGO:KIF3A HGNC:6319 ENTREZ:11127 UNIPROT:Q9Y496 GENECARDS:KIF3A REACTOME:58019 KEGG:11127 WIKI:KIF3A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11208056 PMID:14603322 References_end</body> </html> </notes> <label text="KIF3A"/> <bbox w="80.0" h="40.0" x="18876.5" y="320.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s543_shh1_shh1_sa312"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Kinesin family member 3B HUGO:KIF3B HGNC:6320 ENTREZ:9371 UNIPROT:O15066 GENECARDS:KIF3B REACTOME:58021 KEGG:9371 ATLASONC:GC_KIF3B WIKI:KIF3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11208056 PMID:14603322 References_end Identifiers_begin: Kinesin family member 3B HUGO:KIF3B HGNC:6320 ENTREZ:9371 UNIPROT:O15066 GENECARDS:KIF3B REACTOME:58021 KEGG:9371 ATLASONC:GC_KIF3B WIKI:KIF3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11208056 PMID:14603322 References_end</body> </html> </notes> <label text="KIF3B"/> <bbox w="80.0" h="40.0" x="18878.5" y="362.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s36_shh1_shh1_csa4" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CUL1:RBX1:SKP1:_beta_TRCP* Identifiers_end References_begin: s_shh1_re59(MAP:survival): PMID:16371461 PMID:16651270 Gli3 ubi by bTrCP1 PMID:18813803 s_shh1_re64(MAP:survival): PMID:16611981 Gli2 ubi by bTrCP2 s_akt1_re75:(MAP:survival) PMID:17053147 s_akt1_re158:(MAP:survival) PMID:19797085 References_end</body> </html> </notes> <label text="SCF"/> <bbox w="176.0" h="117.0" x="18656.0" y="1299.5"/> <glyph class="macromolecule" id="shh1_shh1_s70_shh1_shh1_sa27"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Beta-transducin repeat domain HUGO:BTRC HGNC:1144 ENTREZ:8945 UNIPROT:Q9Y297 GENECARDS:BTRC REACTOME:55056 KEGG:8945 ATLASONC:BTRCID451ch10q24 WIKI:BTRC F-box and WD repeat domain containing 11 BTRC2, BTRCP2, Fbw1b, Fbw11, Hos, KIAA0696 HUGO:FBXW11 HGNC:13607 ENTREZ:23291 UNIPROT:Q9UKB1 GENECARDS:FBXW11 REACTOME:55058 KEGG:23291 WIKI:FBXW11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 E3 Ligase subunit References_end Identifiers_begin: Beta-transducin repeat domain HUGO:BTRC HGNC:1144 ENTREZ:8945 UNIPROT:Q9Y297 GENECARDS:BTRC REACTOME:55056 KEGG:8945 ATLASONC:BTRCID451ch10q24 WIKI:BTRC F-box and WD repeat domain containing 11 BTRC2, BTRCP2, Fbw1b, Fbw11, Hos, KIAA0696 HUGO:FBXW11 HGNC:13607 ENTREZ:23291 UNIPROT:Q9UKB1 GENECARDS:FBXW11 REACTOME:55058 KEGG:23291 WIKI:FBXW11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 E3 Ligase subunit References_end</body> </html> Identifiers_begin: Beta-transducin repeat domain HUGO:BTRC HGNC:1144 ENTREZ:8945 UNIPROT:Q9Y297 GENECARDS:BTRC REACTOME:55056 KEGG:8945 ATLASONC:BTRCID451ch10q24 WIKI:BTRC F-box and WD repeat domain containing 11 BTRC2, BTRCP2, Fbw1b, Fbw11, Hos, KIAA0696 HUGO:FBXW11 HGNC:13607 ENTREZ:23291 UNIPROT:Q9UKB1 GENECARDS:FBXW11 REACTOME:55058 KEGG:23291 WIKI:FBXW11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 E3 Ligase subunit References_end</body> </html> </notes> <label text="βTRCP*"/> <bbox w="80.0" h="40.0" x="18662.0" y="1312.5"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s71_shh1_shh1_sa28"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 "S-phase kinase-associated protein 1A (p19A)", SKP1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 "S-phase kinase-associated protein 1A (p19A)", SKP1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> Identifiers_begin: S-phase kinase-associated protein 1 HUGO:SKP1 HGNC:10899 ENTREZ:6500 UNIPROT:P63208 GENECARDS:SKP1 REACTOME:101666 KEGG:6500 ATLASONC:GC_SKP1 WIKI:SKP1 "S-phase kinase-associated protein 1A (p19A)", SKP1A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> </notes> <label text="SKP1"/> <bbox w="80.0" h="40.0" x="18744.0" y="1311.5"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s72_shh1_shh1_sa29"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> Identifiers_begin: Cullin 1 HUGO:CUL1 HGNC:2551 ENTREZ:8454 UNIPROT:Q13616 GENECARDS:CUL1 REACTOME:69762 ATLASONC:GC_CUL1 WIKI:CUL1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:15071497 PMID:15688063 References_end</body> </html> </notes> <label text="CUL1"/> <bbox w="80.0" h="40.0" x="18664.0" y="1355.5"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s73_shh1_shh1_sa30"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> Identifiers_begin: ring-box 1 E3 ubiquitin protein ligase HUGO:RBX1 HGNC:9928 ENTREZ:9978 UNIPROT:P62877 GENECARDS:RBX1 REACTOME:99731 KEGG:9978 ATLASONC:RBX1ID42075ch22q13 WIKI:RBX1 "ring-box 1" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:HIF1 MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:S_PHASE_CHECKPOINT MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:dnarepair / MODULE:NER MAP:dnarepair / MODULE:FANCONI MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:15688063 References_end</body> </html> </notes> <label text="RBX1"/> <bbox w="80.0" h="40.0" x="18748.0" y="1354.5"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s260_shh1_shh1_csa14" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HH Ligand:PTCH* Identifiers_end References_begin: s_shh1_re111:(MAP:survival) PMID:16647304 s_shh1_re112:(MAP:survival) PMID:17848687 s_shh1_re25(MAP:survival): PMID:17641202 PMID:20889716 Tulp3 inhibits MODULE:HEDGEHOG signaling but how exactly is unknown s_shh1_re85:(MAP:survival) PMID:11331587 References_end</body> </html> </notes> <label text="PTC_HH_ligand"/> <bbox w="117.0" h="159.0" x="19082.0" y="102.5"/> <glyph class="macromolecule" id="shh1_shh1_s434_shh1_shh1_sa131"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Patched 1 HUGO:PTCH1 HGNC:9585 ENTREZ:5727 UNIPROT:Q13635 GENECARDS:PTCH1 REACTOME:62393 KEGG:5727 ATLASONC:PTCH100 WIKI:PTCH1 Patched 2 HUGO:PTCH2 HGNC:9586 ENTREZ:8643 UNIPROT:Q9Y6C5 GENECARDS:PTCH2 REACTOME:62395 KEGG:8643 ATLASONC:PTCH2ID41892ch1p34 WIKI:PTCH2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:10021362 PMID:17641202 References_end</body> </html> </notes> <label text="PTCH*"/> <bbox w="78.0" h="114.0" x="19101.0" y="128.0"/> <glyph class="unit of information" id="_bf615c28-ccfc-4a6a-85ac-b9d4071f8e53"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="19117.5" y="123.0"/> </glyph> </glyph> <glyph class="simple chemical" id="shh1_shh1_s435_shh1_shh1_sa132"> <label text="HH Ligand"/> <bbox w="70.0" h="25.0" x="19102.5" y="118.5"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s310_shh1_shh1_csa23" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GLI3-190*:KIF7:SUFU:ULK3 Identifiers_end References_begin: s_shh1_re39(MAP:survival): PMID:20956384 PMID:21209912 PMID:19549984 PMID:19592253 s_shh1_re41(MAP:survival): PMID:20643644 References_end</body> </html> </notes> <label text="SUFU_Gli3"/> <bbox w="206.0" h="168.0" x="19495.5" y="563.0"/> <glyph class="macromolecule" id="shh1_shh1_s436_shh1_shh1_sa165"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 3 HUGO:GLI3 HGNC:4319 ENTREZ:2737 UNIPROT:P10071 GENECARDS:GLI3 KEGG:2737 ATLASONC:GC_GLI3 WIKI:GLI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI3-190*"/> <bbox w="165.0" h="41.0" x="19518.25" y="621.0"/> <glyph class="state variable" id="_91eadf87-319d-432b-bcf7-850ec276fd0d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19545.26" y="616.0"/> </glyph> <glyph class="state variable" id="_44ccdea6-b1a4-44eb-b5e1-377739b9bc3c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19564.771" y="616.0"/> </glyph> <glyph class="state variable" id="_3fe1c9e1-9be8-493a-9ffb-190247f4da3f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19578.234" y="616.0"/> </glyph> <glyph class="state variable" id="_95752d6b-7188-43af-a1b9-37ef0901c581"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19616.605" y="657.0"/> </glyph> <glyph class="state variable" id="_88e31328-1728-4483-b1b7-98da0ad269bd"> <state value="" variable="S860"/> <bbox w="30.0" h="10.0" x="19603.402" y="616.0"/> </glyph> <glyph class="state variable" id="_47734c43-e787-4d99-852a-8a643a5c74ef"> <state value="" variable="S907"/> <bbox w="30.0" h="10.0" x="19550.637" y="657.0"/> </glyph> <glyph class="state variable" id="_e838c34e-f147-4f86-830c-c085c4b86952"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19545.26" y="616.0"/> </glyph> <glyph class="state variable" id="_a1ba39e0-2f7b-4a14-95d0-7668a7086605"> <state value="" variable="S873"/> <bbox w="30.0" h="10.0" x="19668.25" y="636.5653"/> </glyph> <glyph class="state variable" id="_8dfbeab9-7fb7-46ad-8b2c-109c2d6b65e1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19564.771" y="616.0"/> </glyph> <glyph class="state variable" id="_01e3ffae-3aaf-4ed7-b8b0-d7fb65247365"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="19504.266" y="616.0"/> </glyph> <glyph class="state variable" id="_0ab3e4ff-dce1-4851-828d-116d5fc38110"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19578.234" y="616.0"/> </glyph> <glyph class="state variable" id="_bf25cd7a-109b-4c8b-99cc-7f0dca0908a1"> <state value="" variable="S868"/> <bbox w="30.0" h="10.0" x="19661.201" y="616.0"/> </glyph> <glyph class="state variable" id="_a866c45a-e8e7-40a0-8bb0-37f9928e54a2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19616.605" y="657.0"/> </glyph> <glyph class="state variable" id="_eda5e638-b818-4d80-acb6-db8bfa5c6fa9"> <state value="" variable="S877"/> <bbox w="30.0" h="10.0" x="19666.975" y="657.0"/> </glyph> <glyph class="state variable" id="_1de55b90-dcef-4a32-bb90-5feaa806f601"> <state value="" variable="S880"/> <bbox w="30.0" h="10.0" x="19624.35" y="657.0"/> </glyph> <glyph class="state variable" id="_794d7c5b-1f34-4498-a215-81fe0a3d10ce"> <state value="" variable="S903"/> <bbox w="30.0" h="10.0" x="19587.203" y="657.0"/> </glyph> <glyph class="state variable" id="_f3814d7a-6050-428a-8588-e7b856a1fcb2"> <state value="" variable="S910"/> <bbox w="30.0" h="10.0" x="19503.744" y="657.0"/> </glyph> <glyph class="state variable" id="_d77a94cb-7be2-4285-bd01-dfbf8d7a1921"> <state value="" variable="S852"/> <bbox w="30.0" h="10.0" x="19584.166" y="616.0"/> </glyph> <glyph class="state variable" id="_52979aa9-9ebb-4394-92f1-4f8424a1e7ff"> <state value="" variable="S1006"/> <bbox w="35.0" h="10.0" x="19500.75" y="631.0116"/> </glyph> <glyph class="state variable" id="_83e3af09-068e-4eb1-8f97-b2aba07f7fe0"> <state value="" variable="S865"/> <bbox w="30.0" h="10.0" x="19620.707" y="616.0"/> </glyph> <glyph class="state variable" id="_a7dc762f-ea0f-4a7c-aa34-a32fbbfa5b90"> <state value="" variable="S980"/> <bbox w="30.0" h="10.0" x="19503.25" y="638.7311"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s437_shh1_shh1_sa166"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <bbox w="80.0" h="40.0" x="19512.0" y="571.0"/> <glyph class="state variable" id="_fbe231da-67c5-454a-a11e-e8170ebda423"> <state value="" variable="K257"/> <bbox w="30.0" h="10.0" x="19497.492" y="566.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s438_shh1_shh1_sa177"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Kinesin family member 7 HUGO:KIF7 HGNC:30497 ENTREZ:374654 UNIPROT:Q2M1P5 GENECARDS:KIF7 KEGG:374654 WIKI:KIF7 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19666503 PMID:19906571 PMID:19592253 PMID:19549984 References_end</body> </html> </notes> <label text="KIF7"/> <bbox w="80.0" h="40.0" x="19557.5" y="670.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s439_shh1_shh1_sa183"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Unc-51-like kinase 3 HUGO:ULK3 HGNC:19703 ENTREZ:25989 UNIPROT:Q6PHR2 GENECARDS:ULK3 ATLASONC:GC_ULK3 WIKI:ULK3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Unc-51-like kinase PMID:20643644 PMID:19878745 References_end</body> </html> </notes> <label text="ULK3"/> <bbox w="80.0" h="40.0" x="19601.5" y="570.0"/> <glyph class="state variable" id="_11a0a003-4a90-4f43-9895-108e71a38281"> <state value="" variable="S384"/> <bbox w="30.0" h="10.0" x="19665.88" y="605.0"/> </glyph> <glyph class="state variable" id="_3dae20b0-c04e-4c3d-bcf1-38faae43b066"> <state value="" variable="S464"/> <bbox w="30.0" h="10.0" x="19586.5" y="604.7223"/> </glyph> <glyph class="state variable" id="_ebfa01f2-f118-40a5-aa7c-cf34e2e01291"> <state value="" variable="S300"/> <bbox w="30.0" h="10.0" x="19586.992" y="565.0"/> </glyph> <glyph class="state variable" id="_cc97726a-9420-4788-a7e7-2df82819cc71"> <state value="" variable="S350"/> <bbox w="30.0" h="10.0" x="19666.5" y="565.2148"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s309_shh1_shh1_csa22" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GLI2-185*:KIF7:SUFU:ULK3 Identifiers_end References_begin: s_shh1_re38(MAP:survival): PMID:20956384 PMID:21209912 PMID:19549984 PMID:19592253 s_shh1_re40(MAP:survival): PMID:20643644 References_end</body> </html> </notes> <label text="SUFU_Gli2"/> <bbox w="205.0" h="175.0" x="19489.5" y="365.0"/> <glyph class="macromolecule" id="shh1_shh1_s440_shh1_shh1_sa163"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 2 HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Glioma-associated oncogene family zinc finger PMID:18497536 PMID:17845852 PMID:11001584 References_end</body> </html> </notes> <label text="GLI2-185*"/> <bbox w="165.0" h="39.0" x="19513.25" y="423.0"/> <glyph class="state variable" id="_60a7167b-561d-4de6-9185-8f381cbe3a52"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19563.482" y="418.0"/> </glyph> <glyph class="state variable" id="_ff3c3114-da5b-4f6b-aefa-6523693ce325"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19604.979" y="418.0"/> </glyph> <glyph class="state variable" id="_2b055310-fe08-47ad-80eb-28a24c4f1e10"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19611.605" y="457.0"/> </glyph> <glyph class="state variable" id="_4e439c3f-ef5d-41ef-8920-93a35daf8192"> <state value="" variable="S801"/> <bbox w="30.0" h="10.0" x="19566.656" y="418.0"/> </glyph> <glyph class="state variable" id="_838a62c0-1c7f-4f46-a205-9978f4cc515d"> <state value="" variable="K757"/> <bbox w="30.0" h="10.0" x="19498.25" y="430.12466"/> </glyph> <glyph class="state variable" id="_cb4a3a8f-93ef-4f01-b7c8-b9be88d59e65"> <state value="" variable="S956"/> <bbox w="30.0" h="10.0" x="19498.25" y="456.72925"/> </glyph> <glyph class="state variable" id="_7ada6da7-aca5-4e4d-acbc-92a8f52970a7"> <state value="" variable="S817"/> <bbox w="30.0" h="10.0" x="19661.975" y="457.0"/> </glyph> <glyph class="state variable" id="_d4247501-c53e-487b-bbc7-1500cd2fdcca"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19590.75" y="418.0"/> </glyph> <glyph class="state variable" id="_fd5be631-5ba3-4d45-b9bd-bfaab8acab3b"> <state value="" variable="S847"/> <bbox w="30.0" h="10.0" x="19549.47" y="457.0"/> </glyph> <glyph class="state variable" id="_223ffa0c-3de1-4ae6-93b7-9f265e46151a"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="19498.25" y="437.46893"/> </glyph> <glyph class="state variable" id="_e1a925f0-f306-489b-bada-7c74ea46d867"> <state value="" variable="S789"/> <bbox w="30.0" h="10.0" x="19498.25" y="429.6754"/> </glyph> <glyph class="state variable" id="_43c11ec8-6ef3-42e3-8040-e265d839250f"> <state value="" variable="S1011"/> <bbox w="35.0" h="10.0" x="19495.75" y="444.36295"/> </glyph> <glyph class="state variable" id="_2984f24b-fbce-4cff-8b9d-170356bfa195"> <state value="" variable="S805"/> <bbox w="30.0" h="10.0" x="19601.885" y="418.0"/> </glyph> <glyph class="state variable" id="_335ddf67-f9d9-4218-88d3-9809dd1ec42f"> <state value="" variable="S820"/> <bbox w="30.0" h="10.0" x="19626.639" y="457.0"/> </glyph> <glyph class="state variable" id="_2b317197-67d7-4c17-bd79-714b7ec730da"> <state value="" variable="S813"/> <bbox w="30.0" h="10.0" x="19663.25" y="437.5621"/> </glyph> <glyph class="state variable" id="_f3d2392f-ea2f-40a2-9d3e-118fa55f387f"> <state value="" variable="S850"/> <bbox w="30.0" h="10.0" x="19498.25" y="455.9748"/> </glyph> <glyph class="state variable" id="_e0223572-d535-46c4-ba95-bafd129ac7f8"> <state value="" variable="S844"/> <bbox w="30.0" h="10.0" x="19575.596" y="457.0"/> </glyph> <glyph class="state variable" id="_323661a0-e678-4d09-9256-b66e8caca4dd"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="19499.266" y="418.0"/> </glyph> <glyph class="state variable" id="_b430bf94-23ec-4a3d-aa89-0abcc39433af"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19611.605" y="457.0"/> </glyph> <glyph class="state variable" id="_f0790f39-24ec-461b-a692-a14ecc4a5f4e"> <state value="" variable="S808"/> <bbox w="30.0" h="10.0" x="19662.494" y="418.0"/> </glyph> <glyph class="state variable" id="_a1c417c2-0581-407a-a8d1-aa5b7b766cf6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19551.99" y="418.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s441_shh1_shh1_sa164"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <bbox w="80.0" h="40.0" x="19514.0" y="376.0"/> <glyph class="state variable" id="_c237ff0c-596d-4a99-b7f4-855edc570b98"> <state value="" variable="K257"/> <bbox w="30.0" h="10.0" x="19499.492" y="371.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s442_shh1_shh1_sa178"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Kinesin family member 7 HUGO:KIF7 HGNC:30497 ENTREZ:374654 UNIPROT:Q2M1P5 GENECARDS:KIF7 KEGG:374654 WIKI:KIF7 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19666503 PMID:19906571 PMID:19592253 PMID:19549984 References_end</body> </html> </notes> <label text="KIF7"/> <bbox w="80.0" h="40.0" x="19552.5" y="476.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s443_shh1_shh1_sa184"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Unc-51-like kinase 3 HUGO:ULK3 HGNC:19703 ENTREZ:25989 UNIPROT:Q6PHR2 GENECARDS:ULK3 ATLASONC:GC_ULK3 WIKI:ULK3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Unc-51-like kinase PMID:20643644 PMID:19878745 References_end</body> </html> </notes> <label text="ULK3"/> <bbox w="80.0" h="40.0" x="19598.5" y="376.0"/> <glyph class="state variable" id="_e67a96c2-e37e-4560-a60e-941ce3525b0c"> <state value="" variable="S384"/> <bbox w="30.0" h="10.0" x="19662.88" y="411.0"/> </glyph> <glyph class="state variable" id="_afefec80-bfa0-4f5a-8a80-89850d134770"> <state value="" variable="S464"/> <bbox w="30.0" h="10.0" x="19583.5" y="410.7223"/> </glyph> <glyph class="state variable" id="_6da40b78-b7b9-4051-ad21-c2566b84b35c"> <state value="" variable="S300"/> <bbox w="30.0" h="10.0" x="19583.992" y="371.0"/> </glyph> <glyph class="state variable" id="_7b905ba1-b6a7-4df4-944b-ece14f2de4a9"> <state value="" variable="S350"/> <bbox w="30.0" h="10.0" x="19663.5" y="371.21478"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s445_shh1_shh1_csa38" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AOS1*:UBA2 Identifiers_end References_begin: s_shh1_re76(MAP:survival): PMID:20711444 PTM=sumoylation N/A in CellDesigner. Sumoylation not detected on endogenous Gli proteins. PKA antagonise sumoylation due to the consequence of PKA phosphorylation on Gli proteins it is not a direct effect of PKA. Exact References_end</body> </html> </notes> <label text="UBA2_AOS1"/> <bbox w="100.0" h="120.0" x="20085.0" y="704.0"/> <glyph class="macromolecule" id="shh1_shh1_s446_shh1_shh1_sa248"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20711444 References_end</body> </html> </notes> <label text="UBA2"/> <bbox w="80.0" h="40.0" x="20096.5" y="708.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s447_shh1_shh1_sa249"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: AOS1 HUGO:SAE1 HGNC:30660 ENTREZ:10055 UNIPROT:Q9UBE0 GENECARDS:SAE1 KEGG:10055 ATLASONC:GC_SAE1 WIKI:SAE1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20711444 Sumo1 activating enzyme subunit 1 References_end</body> </html> </notes> <label text="AOS1*"/> <bbox w="80.0" h="40.0" x="20098.0" y="751.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s456_shh1_shh1_csa39" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HH Ligand:HHIP1 Identifiers_end References_begin: s_shh1_re79(MAP:survival): PMID:10050855 PMID:16571352 References_end</body> </html> </notes> <label text="HIP1_ligand"/> <bbox w="105.0" h="145.0" x="19969.0" y="98.0"/> <glyph class="macromolecule" id="shh1_shh1_s457_shh1_shh1_sa255"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Hedgehog interacting protein HUGO:HHIP HGNC:14866 ENTREZ:64399 UNIPROT:Q96QV1 GENECARDS:HHIP KEGG:64399 ATLASONC:GC_HHIP WIKI:HHIP Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16571352 PMID:10050855 References_end</body> </html> </notes> <label text="HHIP1"/> <bbox w="78.0" h="114.0" x="19981.5" y="107.0"/> <glyph class="unit of information" id="_7d953f2f-c5f1-46b2-a287-714a4b5c4216"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="19998.0" y="102.0"/> </glyph> </glyph> <glyph class="simple chemical" id="shh1_shh1_s455_shh1_shh1_sa256"> <label text="HH Ligand"/> <bbox w="70.0" h="25.0" x="19987.5" y="101.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s459_shh1_shh1_csa40" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GPC3:HH Ligand Identifiers_end References_begin: s_shh1_re80:(MAP:survival) PMID:18477453 References_end</body> </html> </notes> <label text="GPC3_ligand"/> <bbox w="103.0" h="151.0" x="20210.0" y="103.0"/> <glyph class="macromolecule" id="shh1_shh1_s461_shh1_shh1_sa258"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Glypican 1 HUGO:GPC1 HGNC:4449 ENTREZ:2817 UNIPROT:P35052 GENECARDS:GPC1 REACTOME:55866 KEGG:2817 ATLASONC:GC_GPC1 WIKI:GPC1 Glypican 2 HUGO:GPC2 HGNC:4450 ENTREZ:221914 UNIPROT:Q8N158 GENECARDS:GPC2 REACTOME:230962 WIKI:GPC2 Glypican 3 HUGO:GPC3 HGNC:4451 ENTREZ:2719 UNIPROT:P51654 GENECARDS:GPC3 REACTOME:55868 KEGG:2719 ATLASONC:GPC3ID156 WIKI:GPC3 Glypican 4 HUGO:GPC4 HGNC:4452 ENTREZ:2239 UNIPROT:O75487 GENECARDS:GPC4 REACTOME:55870 KEGG:2239 ATLASONC:GC_GPC4 WIKI:GPC4 Glypican 5 HUGO:GPC5 HGNC:4453 ENTREZ:2262 UNIPROT:P78333 GENECARDS:GPC5 REACTOME:55872 ATLASONC:GPC5ID45705ch13q31 WIKI:GPC5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21112773 PMID:18477453 Glypican References_end</body> </html> </notes> <label text="GPC3"/> <bbox w="78.0" h="114.0" x="20225.5" y="116.0"/> <glyph class="unit of information" id="_c658026b-b916-496f-8553-127f31c2de89"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="20242.0" y="111.0"/> </glyph> </glyph> <glyph class="simple chemical" id="shh1_shh1_s460_shh1_shh1_sa259"> <label text="HH Ligand"/> <bbox w="70.0" h="25.0" x="20229.5" y="106.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s462_shh1_shh1_csa41" compartmentRef="shh1_shh1_c7_shh1_shh1_ca7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GPC3:HH Ligand Identifiers_end References_begin: s_shh1_re81:(MAP:survival) PMID:18477453 References_end</body> </html> </notes> <label text="GPC3_ligand"/> <bbox w="103.0" h="151.0" x="20221.5" y="1940.5"/> <glyph class="macromolecule" id="shh1_shh1_s463_shh1_shh1_sa260"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Glypican 1 HUGO:GPC1 HGNC:4449 ENTREZ:2817 UNIPROT:P35052 GENECARDS:GPC1 REACTOME:55866 KEGG:2817 ATLASONC:GC_GPC1 WIKI:GPC1 Glypican 2 HUGO:GPC2 HGNC:4450 ENTREZ:221914 UNIPROT:Q8N158 GENECARDS:GPC2 REACTOME:230962 WIKI:GPC2 Glypican 3 HUGO:GPC3 HGNC:4451 ENTREZ:2719 UNIPROT:P51654 GENECARDS:GPC3 REACTOME:55868 KEGG:2719 ATLASONC:GPC3ID156 WIKI:GPC3 Glypican 4 HUGO:GPC4 HGNC:4452 ENTREZ:2239 UNIPROT:O75487 GENECARDS:GPC4 REACTOME:55870 KEGG:2239 ATLASONC:GC_GPC4 WIKI:GPC4 Glypican 5 HUGO:GPC5 HGNC:4453 ENTREZ:2262 UNIPROT:P78333 GENECARDS:GPC5 REACTOME:55872 ATLASONC:GPC5ID45705ch13q31 WIKI:GPC5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21112773 PMID:18477453 Glypican References_end</body> </html> </notes> <label text="GPC3"/> <bbox w="78.0" h="114.0" x="20237.0" y="1953.5"/> <glyph class="unit of information" id="_7c848433-2699-4b10-a90b-e6a52894971e"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="20253.5" y="1948.5"/> </glyph> </glyph> <glyph class="simple chemical" id="shh1_shh1_s464_shh1_shh1_sa261"> <label text="HH Ligand"/> <bbox w="70.0" h="25.0" x="20241.0" y="1943.5"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s473_shh1_shh1_csa42" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CyclinB*:PTCH* Identifiers_end References_begin: s_shh1_re83:(MAP:survival) PMID:11331587 References_end</body> </html> </notes> <label text="PTC_CYCLINB"/> <bbox w="122.0" h="190.0" x="19387.0" y="104.0"/> <glyph class="macromolecule" id="shh1_shh1_s474_shh1_shh1_sa263"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Patched 1 HUGO:PTCH1 HGNC:9585 ENTREZ:5727 UNIPROT:Q13635 GENECARDS:PTCH1 REACTOME:62393 KEGG:5727 ATLASONC:PTCH100 WIKI:PTCH1 Patched 2 HUGO:PTCH2 HGNC:9586 ENTREZ:8643 UNIPROT:Q9Y6C5 GENECARDS:PTCH2 REACTOME:62395 KEGG:8643 ATLASONC:PTCH2ID41892ch1p34 WIKI:PTCH2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:10021362 PMID:17641202 References_end</body> </html> </notes> <label text="PTCH*"/> <bbox w="78.0" h="114.0" x="19412.5" y="110.0"/> <glyph class="unit of information" id="_d5661bb6-932e-4d59-aa50-edc9d5a55d75"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="19429.0" y="105.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s476_shh1_shh1_sa265"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Cyclin B1 HUGO:CCNB1 HGNC:1579 ENTREZ:891 UNIPROT:P14635 GENECARDS:CCNB1 REACTOME:87210 KEGG:891 ATLASONC:CCNB1ID951ch5q13 WIKI:CCNB1 Identifiers_end Maps_Modules_begin: MAP:cellcycle / MODULE:CYCLINB MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11331587 PMID:16489008 References_end</body> </html> </notes> <label text="CyclinB*"/> <bbox w="80.0" h="40.0" x="19412.5" y="225.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s488_shh1_shh1_csa43" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ITCH:NUMB Identifiers_end References_begin: s_shh1_re89(MAP:survival): PMID:20818436 PMID:17115028 PMID:17312394 s_shh1_re90(MAP:survival): References-begin: References_end</body> </html> </notes> <label text="ITCH_NUMB"/> <bbox w="100.0" h="120.0" x="19064.0" y="2369.0"/> <glyph class="macromolecule" id="shh1_shh1_s490_shh1_shh1_sa273"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NUMB HUGO:NUMB HGNC:8060 ENTREZ:8650 UNIPROT:P49757 GENECARDS:NUMB REACTOME:60616 KEGG:8650 ATLASONC:NUMBID43702ch14q24 WIKI:NUMB Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20940030 References_end</body> </html> </notes> <label text="NUMB"/> <bbox w="80.0" h="40.0" x="19076.5" y="2425.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s491_shh1_shh1_sa274"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Itchy HUGO:ITCH HGNC:13890 ENTREZ:83737 UNIPROT:Q96J02 GENECARDS:ITCH REACTOME:93459 KEGG:83737 ATLASONC:GC_ITCH WIKI:ITCH Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18552861 E3 ubiquitin protein ligase homologue References_end</body> </html> </notes> <label text="ITCH"/> <bbox w="80.0" h="40.0" x="19076.5" y="2381.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s500_shh1_shh1_csa44" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GLI1:SUFU Identifiers_end References_begin: s_shh1_re95:(MAP:survival) PMID:10559945 References_end</body> </html> </notes> <label text="Gli_SUFU"/> <bbox w="100.0" h="120.0" x="19452.0" y="2224.0"/> <glyph class="macromolecule" id="shh1_shh1_s501_shh1_shh1_sa284"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 1 HUGO:GLI1 HGNC:4317 ENTREZ:2735 UNIPROT:P08151 GENECARDS:GLI1 KEGG:2735 ATLASONC:GLIID310ch12q13 WIKI:GLI1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI1"/> <bbox w="80.0" h="40.0" x="19461.5" y="2229.0"/> <glyph class="state variable" id="_c74a91e4-47b0-4f67-b7ef-2c3e6bc56199"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19456.5" y="2224.0"/> </glyph> <glyph class="state variable" id="_0c2d422a-9f03-4a98-8a9c-b0341262be8d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19456.5" y="2264.0"/> </glyph> <glyph class="state variable" id="_b7808d25-38cd-4b56-9251-69defa54e7a6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19536.5" y="2224.0"/> </glyph> <glyph class="state variable" id="_88d137f8-aa4b-40ba-aa5a-2867b9e2929d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19536.5" y="2264.0"/> </glyph> <glyph class="state variable" id="_35e79dae-316f-401d-98af-c18c17a7a531"> <state value="" variable="T374"/> <bbox w="30.0" h="10.0" x="19525.88" y="2264.0"/> </glyph> <glyph class="state variable" id="_1f95ef96-b0d0-4612-9d41-3af0b19365bf"> <state value="" variable="S640"/> <bbox w="30.0" h="10.0" x="19446.5" y="2263.7224"/> </glyph> <glyph class="state variable" id="_58894dc4-ce34-4e87-bedd-e1638ed6494f"> <state value="" variable="K518"/> <bbox w="30.0" h="10.0" x="19469.475" y="2264.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s502_shh1_shh1_sa285"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <bbox w="80.0" h="40.0" x="19460.25" y="2282.0"/> <glyph class="state variable" id="_2776c6b5-6e83-40cf-a5a3-385809bc1cfb"> <state value="" variable="K257"/> <bbox w="30.0" h="10.0" x="19445.742" y="2277.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s507_shh1_shh1_csa46" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:SIL*:SUFU Identifiers_end References_begin: s_shh1_re97:(MAP:survival) PMID:18829525 References_end</body> </html> </notes> <label text="SIL_SUFU"/> <bbox w="100.0" h="120.0" x="19629.0" y="2224.0"/> <glyph class="macromolecule" id="shh1_shh1_s512_shh1_shh1_sa290"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: SIL HUGO:STIL HGNC:10879 ENTREZ:6491 UNIPROT:Q15468 GENECARDS:STIL KEGG:6491 ATLASONC:SILID524ch1p32 WIKI:STIL Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:10385121 References_end</body> </html> </notes> <label text="SIL*"/> <bbox w="80.0" h="40.0" x="19635.5" y="2238.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s511_shh1_shh1_sa291"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <bbox w="80.0" h="40.0" x="19638.375" y="2282.0"/> <glyph class="state variable" id="_c6d4003e-b2ae-4f15-a642-6c2f7b27c12e"> <state value="" variable="K257"/> <bbox w="30.0" h="10.0" x="19623.867" y="2277.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s541_shh1_shh1_csa51" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:KIF3A:KIF3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11208056 s_shh1_re33:(MAP:survival) PMID:18497258 s_wca1_re55:(MAP:survival) PMID:15852005 s_wca1_re57(MAP:survival): PMID:19718039 PMID:21602792 In presence of WNT ligand References_end</body> </html> </notes> <label text="Kif3"/> <bbox w="100.0" h="120.0" x="18546.0" y="626.0"/> <glyph class="macromolecule" id="shh1_shh1_s294_shh1_shh1_sa152"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Kinesin family member 3A HUGO:KIF3A HGNC:6319 ENTREZ:11127 UNIPROT:Q9Y496 GENECARDS:KIF3A REACTOME:58019 KEGG:11127 WIKI:KIF3A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11208056 PMID:14603322 References_end Identifiers_begin: Kinesin family member 3A HUGO:KIF3A HGNC:6319 ENTREZ:11127 UNIPROT:Q9Y496 GENECARDS:KIF3A REACTOME:58019 KEGG:11127 WIKI:KIF3A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11208056 PMID:14603322 References_end</body> </html> </notes> <label text="KIF3A"/> <bbox w="80.0" h="40.0" x="18552.75" y="637.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s540_shh1_shh1_sa310"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Kinesin family member 3B HUGO:KIF3B HGNC:6320 ENTREZ:9371 UNIPROT:O15066 GENECARDS:KIF3B REACTOME:58021 KEGG:9371 ATLASONC:GC_KIF3B WIKI:KIF3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11208056 PMID:14603322 References_end Identifiers_begin: Kinesin family member 3B HUGO:KIF3B HGNC:6320 ENTREZ:9371 UNIPROT:O15066 GENECARDS:KIF3B REACTOME:58021 KEGG:9371 ATLASONC:GC_KIF3B WIKI:KIF3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11208056 PMID:14603322 References_end</body> </html> </notes> <label text="KIF3B"/> <bbox w="80.0" h="40.0" x="18552.75" y="679.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s545_shh1_shh1_csa52" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:KIF3A:KIF3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11208056 s_shh1_re40(MAP:survival): PMID:20956384 PMID:20643644 References_end</body> </html> </notes> <label text="Kif3"/> <bbox w="100.0" h="120.0" x="19361.0" y="563.0"/> <glyph class="macromolecule" id="shh1_shh1_s301_shh1_shh1_sa158"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Kinesin family member 3A HUGO:KIF3A HGNC:6319 ENTREZ:11127 UNIPROT:Q9Y496 GENECARDS:KIF3A REACTOME:58019 KEGG:11127 WIKI:KIF3A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11208056 PMID:14603322 References_end Identifiers_begin: Kinesin family member 3A HUGO:KIF3A HGNC:6319 ENTREZ:11127 UNIPROT:Q9Y496 GENECARDS:KIF3A REACTOME:58019 KEGG:11127 WIKI:KIF3A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11208056 PMID:14603322 References_end</body> </html> </notes> <label text="KIF3A"/> <bbox w="80.0" h="40.0" x="19372.125" y="570.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s544_shh1_shh1_sa313"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Kinesin family member 3B HUGO:KIF3B HGNC:6320 ENTREZ:9371 UNIPROT:O15066 GENECARDS:KIF3B REACTOME:58021 KEGG:9371 ATLASONC:GC_KIF3B WIKI:KIF3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11208056 PMID:14603322 References_end Identifiers_begin: Kinesin family member 3B HUGO:KIF3B HGNC:6320 ENTREZ:9371 UNIPROT:O15066 GENECARDS:KIF3B REACTOME:58021 KEGG:9371 ATLASONC:GC_KIF3B WIKI:KIF3B Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11208056 PMID:14603322 References_end</body> </html> </notes> <label text="KIF3B"/> <bbox w="80.0" h="40.0" x="19372.5" y="614.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s571_shh1_shh1_csa56" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GAS1:HH Ligand Identifiers_end References_begin: s_shh1_re112:(MAP:survival) PMID:17848687 References_end</body> </html> </notes> <label text="GAS1_ligand"/> <bbox w="87.0" h="121.0" x="19613.0" y="115.0"/> <glyph class="macromolecule" id="shh1_shh1_s567_shh1_shh1_sa328"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Growth arrest-specific 1 HUGO:GAS1 HGNC:4165 ENTREZ:2619 UNIPROT:P54826 GENECARDS:GAS1 ATLASONC:GC_GAS1 WIKI:GAS1 Growth arrest-specific 2 HUGO:GAS2 HGNC:4167 ENTREZ:2620 UNIPROT:O43903 GENECARDS:GAS2 REACTOME:55326 ATLASONC:GC_GAS2 WIKI:GAS2 Growth arrest-specific 5 HUGO:GAS5 HGNC:16355 ENTREZ:60674 GENECARDS:GAS5 KEGG:60674 ATLASONC:GAS5ID50217ch1q25 WIKI:GAS5 Growth arrest-specific 6 HUGO:GAS6 HGNC:4168 ENTREZ:2621 UNIPROT:Q14393 GENECARDS:GAS6 REACTOME:147759 KEGG:2621 ATLASONC:GC_GAS6 WIKI:GAS6 Growth arrest-specific 7 HUGO:GAS7 HGNC:4169 ENTREZ:8522 UNIPROT:O60861 GENECARDS:GAS7 KEGG:8522 ATLASONC:GAS7ID257 WIKI:GAS7 Growth arrest-specific 8 HUGO:GAS8 HGNC:4166 ENTREZ:2622 UNIPROT:O95995 GENECARDS:GAS8 KEGG:2622 ATLASONC:GC_GAS8 WIKI:GAS8 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17848687 References_end</body> </html> </notes> <label text="GAS1"/> <bbox w="80.0" h="50.0" x="19615.0" y="145.0"/> <glyph class="unit of information" id="_e69e75a6-4f05-475d-b891-525a16682172"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="19632.5" y="140.0"/> </glyph> </glyph> <glyph class="simple chemical" id="shh1_shh1_s572_shh1_shh1_sa331"> <label text="HH Ligand"/> <bbox w="70.0" h="25.0" x="19617.5" y="126.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s573_shh1_shh1_csa57" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDO*:HH Ligand Identifiers_end References_begin: s_shh1_re111:(MAP:survival) PMID:16647304 References_end</body> </html> </notes> <label text="CDO_ligand"/> <bbox w="88.0" h="116.0" x="19518.0" y="117.0"/> <glyph class="macromolecule" id="shh1_shh1_s568_shh1_shh1_sa329"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Cdo HUGO:CDON HGNC:17104 ENTREZ:50937 UNIPROT:Q4KMG0 GENECARDS:CDON REACTOME:197924 KEGG:50937 ATLASONC:GC_CDON WIKI:CDON Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16647304 References_end</body> </html> </notes> <label text="CDO*"/> <bbox w="80.0" h="50.0" x="19519.0" y="147.0"/> <glyph class="unit of information" id="_8f75bff9-5a7e-4d56-9089-e29e5e555045"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="19536.5" y="142.0"/> </glyph> </glyph> <glyph class="simple chemical" id="shh1_shh1_s569_shh1_shh1_sa330"> <label text="HH Ligand"/> <bbox w="70.0" h="25.0" x="19524.5" y="127.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s576_shh1_shh1_csa58" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BOC:HH Ligand Identifiers_end References_begin: s_shh1_re114:(MAP:survival) PMID:16647304 References_end</body> </html> </notes> <label text="BOC_ligand"/> <bbox w="84.0" h="120.0" x="19706.0" y="115.0"/> <glyph class="macromolecule" id="shh1_shh1_s574_shh1_shh1_sa332"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: brother of CDO HUGO:BOC HGNC:17173 ENTREZ:91653 UNIPROT:Q9BWV1 GENECARDS:BOC REACTOME:197762 KEGG:91653 ATLASONC:GC_BOC WIKI:BOC Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11782431 PMID:16647304 References_end</body> </html> </notes> <label text="BOC"/> <bbox w="80.0" h="50.0" x="19707.0" y="148.0"/> <glyph class="unit of information" id="_b747e24d-0e18-40c1-8976-7fd3c7dd1218"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="19724.5" y="143.0"/> </glyph> </glyph> <glyph class="simple chemical" id="shh1_shh1_s575_shh1_shh1_sa333"> <label text="HH Ligand"/> <bbox w="70.0" h="25.0" x="19710.5" y="127.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s581_shh1_shh1_csa59" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GDP:G_alpha__sub_i_endsub_*:G_beta__sub_i_endsub_*:G_gamma__sub_i_endsub_*:SMO Identifiers_end References_begin: s_shh1_re26(MAP:survival): PMID:10021362 PMID:18815277 PMID:17430994 References_end</body> </html> </notes> <label text="SMO_Gi_proteins"/> <bbox w="137.0" h="143.0" x="18530.0" y="133.0"/> <glyph class="macromolecule" id="shh1_shh1_s278_shh1_shh1_sa134"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Smoothened HUGO:SMO HGNC:11119 ENTREZ:6608 UNIPROT:Q99835 GENECARDS:SMO REACTOME:64670 KEGG:6608 ATLASONC:GC_SMO WIKI:SMO Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18820483 PMID:17641202 Smoothened homologue (Drosophila) References_end</body> </html> </notes> <label text="SMO"/> <bbox w="80.0" h="40.0" x="18558.5" y="144.5"/> <glyph class="state variable" id="_42002336-f0ec-408d-9adc-03405ba6bd6f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18633.5" y="139.5"/> </glyph> <glyph class="state variable" id="_9010a799-9f5a-4144-8fbd-9fec40a3ea42"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18633.5" y="139.5"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s578_shh1_shh1_sa334"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 Guanine nucleotide binding protein (G-protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 Guanine nucleotide binding protein (G-protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17430994 Guanine nucleotide binding protein (G-protein) References_end</body> </html> </notes> <label text="Gαi*"/> <bbox w="40.0" h="30.0" x="18538.0" y="201.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s579_shh1_shh1_sa335"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein) beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein) beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein) beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein) beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein) beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17430994 References_end</body> </html> </notes> <label text="Gβi*"/> <bbox w="40.0" h="30.0" x="18579.0" y="201.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s580_shh1_shh1_sa336"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein) gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein) gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein) gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein) gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein) gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein) gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein) gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein) gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein) gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein) gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17430994 References_end</body> </html> </notes> <label text="Gγi*"/> <bbox w="40.0" h="30.0" x="18620.0" y="201.0"/> </glyph> <glyph class="simple chemical" id="shh1_shh1_s582_shh1_shh1_sa337"> <label text="GDP"/> <bbox w="30.0" h="30.0" x="18546.0" y="224.5"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s589_shh1_shh1_csa60" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GTP:G_alpha__sub_i_endsub_* Identifiers_end References_begin: s_shh1_re27:(MAP:survival) PMID:17430994 References_end</body> </html> </notes> <label text="GαiGTP"/> <bbox w="57.0" h="90.0" x="18214.5" y="287.0"/> <glyph class="macromolecule" id="shh1_shh1_s588_shh1_shh1_sa345"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 Guanine nucleotide binding protein (G-protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 Guanine nucleotide binding protein (G-protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17430994 Guanine nucleotide binding protein (G-protein) References_end</body> </html> </notes> <label text="Gαi*"/> <bbox w="40.0" h="30.0" x="18221.5" y="295.0"/> </glyph> <glyph class="simple chemical" id="shh1_shh1_s590_shh1_shh1_sa346"> <label text="GTP"/> <bbox w="30.0" h="30.0" x="18226.75" y="325.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s593_shh1_shh1_csa61" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:G_beta__sub_i_endsub_*:G_gamma__sub_i_endsub_* Identifiers_end References_begin: s_shh1_re27:(MAP:survival) PMID:17430994 s_shh1_re115(MAP:survival): PMID:12764189 PMID:18815277 References_end</body> </html> </notes> <label text="Gβi_endsubγdimer"/> <bbox w="102.0" h="62.0" x="18282.0" y="299.0"/> <glyph class="macromolecule" id="shh1_shh1_s591_shh1_shh1_sa347"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein) beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein) beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein) beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein) beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein) beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17430994 References_end</body> </html> </notes> <label text="Gβi*"/> <bbox w="40.0" h="30.0" x="18291.5" y="307.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s592_shh1_shh1_sa348"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein) gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein) gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein) gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein) gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein) gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein) gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein) gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein) gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein) gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein) gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17430994 References_end</body> </html> </notes> <label text="Gγi*"/> <bbox w="40.0" h="30.0" x="18334.5" y="307.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s596_shh1_shh1_csa62" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GRK*:G_beta__sub_i_endsub_*:G_gamma__sub_i_endsub_* Identifiers_end References_begin: s_shh1_re115(MAP:survival): PMID:12764189 PMID:18815277 s_shh1_re28:(MAP:survival) PMID:15618519 References_end</body> </html> </notes> <label text="GRK_Gβi_endsubγdimer"/> <bbox w="105.0" h="109.0" x="18547.0" y="497.0"/> <glyph class="macromolecule" id="shh1_shh1_s597_shh1_shh1_sa144"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adrenergic beta receptor kinase 1 HUGO:ADRBK1 HGNC:289 ENTREZ:156 UNIPROT:P25098 adrenergic beta receptor kinase 2 HUGO:ADRBK2 HGNC:290 ENTREZ:157 UNIPROT:P35626 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN. PMID:11226259 References_end Identifiers_begin: G protein-coupled receptor kinase 1 HUGO:GRK1 HGNC:10013 ENTREZ:6011 UNIPROT:Q15835 GENECARDS:GRK1 KEGG:6011 ATLASONC:GC_GRK1 WIKI:GRK1 G protein-coupled receptor kinase 4 HUGO:GRK4 HGNC:4543 ENTREZ:2868 UNIPROT:P32298 GENECARDS:GRK4 KEGG:2868 ATLASONC:GC_GRK4 WIKI:GRK4 G protein-coupled receptor kinase 5 HUGO:GRK5 HGNC:4544 ENTREZ:2869 UNIPROT:P34947 GENECARDS:GRK5 REACTOME:55956 KEGG:2869 WIKI:GRK5 G protein-coupled receptor kinase 6 HUGO:GRK6 HGNC:4545 ENTREZ:2870 UNIPROT:P43250 GENECARDS:GRK6 KEGG:2870 ATLASONC:GC_GRK6 WIKI:GRK6 G protein-coupled receptor kinase 7 HUGO:GRK7 HGNC:17031 ENTREZ:131890 UNIPROT:Q8WTQ7 GENECARDS:GRK7 KEGG:131890 WIKI:GRK7 adrenergic beta receptor kinase 1 HUGO:ADRBK1 HGNC:289 ENTREZ:156 UNIPROT:P25098 GENECARDS:ADRBK1 REACTOME:50271 KEGG:156 ATLASONC:GC_ADRBK1 WIKI:ADRBK1 adrenergic beta receptor kinase 2 HUGO:ADRBK2 HGNC:290 ENTREZ:157 UNIPROT:P35626 GENECARDS:ADRBK2 KEGG:157 ATLASONC:GC_ADRBK2 WIKI:ADRBK2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK Maps_Modules_end References_begin: PMID:16525728 PMID:15618519 Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN. PMID:11226259 References_end</body> </html> </notes> <label text="GRK*"/> <bbox w="80.0" h="40.0" x="18559.0" y="505.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s598_shh1_shh1_sa351"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein) beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein) beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein) beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein) beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein) beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17430994 References_end</body> </html> </notes> <label text="Gβi*"/> <bbox w="40.0" h="30.0" x="18557.5" y="549.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s599_shh1_shh1_sa352"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein) gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein) gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein) gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein) gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein) gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein) gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein) gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein) gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein) gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein) gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17430994 References_end</body> </html> </notes> <label text="Gγi*"/> <bbox w="40.0" h="30.0" x="18600.5" y="548.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s600_shh1_shh1_csa48" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AKT*:PI3,4,5-P3 Identifiers_end References_begin: s_shh1_re101:(MAP:survival) PMID:17688959 References_end</body> </html> </notes> <label text="(PIP3_AKT)"/> <bbox w="100.0" h="120.0" x="18136.5" y="124.0"/> <glyph class="simple chemical" id="shh1_shh1_s522_shh1_shh1_sa299"> <label text="PI3,4,5-P3"/> <bbox w="70.0" h="25.0" x="18148.5" y="137.5"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s526_shh1_shh1_sa300"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 GENECARDS:AKT2 REACTOME:49860 KEGG:208 ATLASONC:AKT2ID517ch19q13 WIKI:AKT2 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:CDH2 HGNC:1759 ENTREZ:1000 UNIPROT:P19022 GENECARDS:CDH2 REACTOME:51212 KEGG:1000 ATLASONC:GC_CDH2 WIKI:CDH2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end</body> </html> Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 GENECARDS:AKT2 REACTOME:49860 KEGG:208 ATLASONC:AKT2ID517ch19q13 WIKI:AKT2 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:CDH2 HGNC:1759 ENTREZ:1000 UNIPROT:P19022 GENECARDS:CDH2 REACTOME:51212 KEGG:1000 ATLASONC:GC_CDH2 WIKI:CDH2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end</body> </html> Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 GENECARDS:AKT2 REACTOME:49860 KEGG:208 ATLASONC:AKT2ID517ch19q13 WIKI:AKT2 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:CDH2 HGNC:1759 ENTREZ:1000 UNIPROT:P19022 GENECARDS:CDH2 REACTOME:51212 KEGG:1000 ATLASONC:GC_CDH2 WIKI:CDH2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end</body> </html> </notes> <label text="AKT*"/> <bbox w="80.0" h="40.0" x="18146.5" y="176.0"/> <glyph class="state variable" id="_ea6cfbac-8a7d-46ff-ac57-7ef27053b1ae"> <state value="" variable="S129"/> <bbox w="30.0" h="10.0" x="18131.5" y="210.7223"/> </glyph> <glyph class="state variable" id="_8fd79ad8-5e8c-4afd-a2fb-c490be5268f0"> <state value="" variable="T450"/> <bbox w="30.0" h="10.0" x="18211.5" y="171.21477"/> </glyph> <glyph class="state variable" id="_e7f864b6-a7ab-4e93-9bed-6b408409dd2b"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="18210.88" y="211.0"/> </glyph> <glyph class="state variable" id="_0c92a5b9-e12c-4b44-9fa2-b551b7e31e10"> <state value="" variable="T308"/> <bbox w="30.0" h="10.0" x="18131.992" y="171.0"/> </glyph> <glyph class="state variable" id="_8046dcce-1995-4f36-9935-b110757ff230"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18221.5" y="171.0"/> </glyph> <glyph class="state variable" id="_3ae67f83-b3bc-4f17-a150-3b64385c0487"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18141.5" y="191.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s602_shh1_shh1_csa53" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:IFT122:IFT140:WDR19 Identifiers_end References_begin: s_shh1_re48(MAP:survival): PMID:20360384 PMID:19996169 PMID:18559511 s_shh1_re108:(MAP:survival) PMID:20889716 References_end</body> </html> </notes> <label text="(IFT-A complex)"/> <bbox w="251.0" h="89.0" x="19577.0" y="1439.0"/> <glyph class="macromolecule" id="shh1_shh1_s550_shh1_shh1_sa314"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Intraflagellar transport 122 homologue (Chlamydomonas) HUGO:IFT122 HGNC:13556 ENTREZ:55764 UNIPROT:Q9HBG6 GENECARDS:IFT122 KEGG:55764 WIKI:IFT122 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20889716 References_end</body> </html> </notes> <label text="IFT122"/> <bbox w="80.0" h="40.0" x="19662.0" y="1459.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s551_shh1_shh1_sa315"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Intraflagellar transport 140 homologue (Chlamydomonas) HUGO:IFT140 HGNC:29077 ENTREZ:9742 UNIPROT:Q96RY7 GENECARDS:IFT140 KEGG:9742 WIKI:IFT140 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20889716 References_end</body> </html> </notes> <label text="IFT140"/> <bbox w="80.0" h="40.0" x="19743.0" y="1459.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s552_shh1_shh1_sa316"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: WD repeat domain 19 HUGO:WDR19 HGNC:18340 ENTREZ:57728 UNIPROT:Q8NEZ3 GENECARDS:WDR19 KEGG:57728 ATLASONC:GC_WDR19 WIKI:WDR19 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:12906858 References_end</body> </html> </notes> <label text="WDR19"/> <bbox w="80.0" h="40.0" x="19581.0" y="1459.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s603_shh1_shh1_csa54" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:IFT122:IFT140:TULP3:WDR19 Identifiers_end References_begin: s_shh1_re108:(MAP:survival) PMID:20889716 References_end</body> </html> </notes> <label text="(IFT-A_TULP3)"/> <bbox w="184.0" h="126.0" x="19309.0" y="1511.0"/> <glyph class="macromolecule" id="shh1_shh1_s554_shh1_shh1_sa317"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Tubby like protein 3 HUGO:TULP3 HGNC:12425 ENTREZ:7289 UNIPROT:O75386 GENECARDS:TULP3 KEGG:7289 ATLASONC:GC_TULP3 WIKI:TULP3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20889716 PMID:19286674 PMID:19334287 References_end</body> </html> </notes> <label text="TULP3"/> <bbox w="80.0" h="40.0" x="19403.0" y="1569.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s555_shh1_shh1_sa318"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: WD repeat domain 19 HUGO:WDR19 HGNC:18340 ENTREZ:57728 UNIPROT:Q8NEZ3 GENECARDS:WDR19 KEGG:57728 ATLASONC:GC_WDR19 WIKI:WDR19 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:12906858 References_end</body> </html> </notes> <label text="WDR19"/> <bbox w="80.0" h="40.0" x="19402.5" y="1527.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s556_shh1_shh1_sa319"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Intraflagellar transport 122 homologue (Chlamydomonas) HUGO:IFT122 HGNC:13556 ENTREZ:55764 UNIPROT:Q9HBG6 GENECARDS:IFT122 KEGG:55764 WIKI:IFT122 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20889716 References_end</body> </html> </notes> <label text="IFT122"/> <bbox w="80.0" h="40.0" x="19319.5" y="1569.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s557_shh1_shh1_sa320"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Intraflagellar transport 140 homologue (Chlamydomonas) HUGO:IFT140 HGNC:29077 ENTREZ:9742 UNIPROT:Q96RY7 GENECARDS:IFT140 KEGG:9742 WIKI:IFT140 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20889716 References_end</body> </html> </notes> <label text="IFT140"/> <bbox w="80.0" h="40.0" x="19319.5" y="1527.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s604_shh1_shh1_csa45" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PP2A_A*:PP2A_B55_alpha_*:PP2A_C* Identifiers_end References_begin: s_shh1_re48(MAP:survival): PMID:20360384 PMID:19996169 PMID:18559511 s_akt1_re24:(MAP:survival) PMID:18042541 PMID:18077353 References_end</body> </html> </notes> <label text="(PP2A)"/> <bbox w="106.0" h="152.0" x="19920.0" y="1380.0"/> <glyph class="macromolecule" id="shh1_shh1_s504_shh1_shh1_sa286"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: protein phosphatase 2 regulatory subunit A alpha HUGO:PPP2R1A HGNC:9302 ENTREZ:5518 UNIPROT:P30153 GENECARDS:PPP2R1A REACTOME:49125 KEGG:5518 ATLASONC:GC_PPP2R1A WIKI:PPP2R1A protein phosphatase 2 regulatory subunit B beta HUGO:PPP2R1B HGNC:9303 ENTREZ:5519 UNIPROT:P30154 GENECARDS:PPP2R1B REACTOME:49127 KEGG:5519 ATLASONC:GC_PPP2R1B WIKI:PPP2R1B PP2A-Aalpha, PR65A, "protein phosphatase 2, 65kDa regulatory subunit A", "protein phosphatase 2A, regulatory subunit A, alpha isoform" protein phosphatase 2, regulatory subunit A, beta Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18559511 PMID:10026142 Structural sub-unit References_end Identifiers_begin: protein phosphatase 2 regulatory subunit A alpha HUGO:PPP2R1A HGNC:9302 ENTREZ:5518 UNIPROT:P30153 GENECARDS:PPP2R1A REACTOME:49125 KEGG:5518 ATLASONC:GC_PPP2R1A WIKI:PPP2R1A protein phosphatase 2 regulatory subunit B beta HUGO:PPP2R1B HGNC:9303 ENTREZ:5519 UNIPROT:P30154 GENECARDS:PPP2R1B REACTOME:49127 KEGG:5519 ATLASONC:GC_PPP2R1B WIKI:PPP2R1B PP2A-Aalpha, PR65A, "protein phosphatase 2, 65kDa regulatory subunit A", "protein phosphatase 2A, regulatory subunit A, alpha isoform" protein phosphatase 2, regulatory subunit A, beta Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18559511 PMID:10026142 Structural sub-unit References_end</body> </html> Identifiers_begin: protein phosphatase 2 regulatory subunit A alpha HUGO:PPP2R1A HGNC:9302 ENTREZ:5518 UNIPROT:P30153 GENECARDS:PPP2R1A REACTOME:49125 KEGG:5518 ATLASONC:GC_PPP2R1A WIKI:PPP2R1A protein phosphatase 2 regulatory subunit B beta HUGO:PPP2R1B HGNC:9303 ENTREZ:5519 UNIPROT:P30154 GENECARDS:PPP2R1B REACTOME:49127 KEGG:5519 ATLASONC:GC_PPP2R1B WIKI:PPP2R1B PP2A-Aalpha, PR65A, "protein phosphatase 2, 65kDa regulatory subunit A", "protein phosphatase 2A, regulatory subunit A, alpha isoform" protein phosphatase 2, regulatory subunit A, beta Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18559511 PMID:10026142 Structural sub-unit References_end</body> </html> </notes> <label text="PP2A_A*"/> <bbox w="80.0" h="40.0" x="19932.5" y="1390.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s505_shh1_shh1_sa287"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 References_end Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> Identifiers_begin: protein phosphatase 2 catalytic subunit alpha isozyme HUGO:PPP2CA HGNC:9299 ENTREZ:5515 UNIPROT:P67775 GENECARDS:PPP2CA REACTOME:61096 KEGG:5515 ATLASONC:GC_PPP2CA WIKI:PPP2CA P67775 protein phosphatase 2 catalytic subunit beta isozyme HUGO:PPP2CB HGNC:9300 ENTREZ:5516 UNIPROT:P62714 GENECARDS:PPP2CB REACTOME:61104 KEGG:5516 ATLASONC:GC_PPP2CB WIKI:PPP2CB P62714 "protein phosphatase 2 (formerly 2A) catalytic subunit alpha isoform" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18042541 PMID:10995457 PMID:16680151 MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 PMID:18588945 References_end</body> </html> </notes> <label text="PP2A_C*"/> <bbox w="80.0" h="40.0" x="19932.5" y="1428.0"/> <glyph class="state variable" id="_bb382a6c-53ed-4bda-9c65-9bc5acdfca7f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19927.5" y="1443.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s506_shh1_shh1_sa288"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: protein phosphatase 2 regulatory subunit B alpha isozyme HUGO:PPP2R2A HGNC:9304 ENTREZ:5520 UNIPROT:P63151 GENECARDS:PPP2R2A REACTOME:49129 KEGG:5520 ATLASONC:GC_PPP2R2A WIKI:PPP2R2A protein phosphatase 2 regulatory subunit B alpha P63151 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18042541 PMID:19556239 PMID:10995457 PMID:16680151 References_end Identifiers_begin: protein phosphatase 2 regulatory subunit B alpha isozyme HUGO:PPP2R2A HGNC:9304 ENTREZ:5520 UNIPROT:P63151 GENECARDS:PPP2R2A REACTOME:49129 KEGG:5520 ATLASONC:GC_PPP2R2A WIKI:PPP2R2A protein phosphatase 2 regulatory subunit B alpha P63151 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18042541 PMID:19556239 PMID:10995457 PMID:16680151 References_end</body> </html> </notes> <label text="PP2A_B55α*"/> <bbox w="80.0" h="40.0" x="19932.5" y="1468.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s605_shh1_shh1_csa55" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:IFT122:IFT140:TULP3:WDR19 Identifiers_end References_begin: s_shh1_re110:(MAP:survival) PMID:20889716 s_shh1_re25(MAP:survival): PMID:17641202 PMID:20889716 Tulp3 inhibits MODULE:HEDGEHOG signaling but how exactly is unknown References_end</body> </html> </notes> <label text="(IFT-A_TULP3)"/> <bbox w="184.0" h="126.0" x="19754.5" y="597.0"/> <glyph class="macromolecule" id="shh1_shh1_s561_shh1_shh1_sa322"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Tubby like protein 3 HUGO:TULP3 HGNC:12425 ENTREZ:7289 UNIPROT:O75386 GENECARDS:TULP3 KEGG:7289 ATLASONC:GC_TULP3 WIKI:TULP3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20889716 PMID:19286674 PMID:19334287 References_end</body> </html> </notes> <label text="TULP3"/> <bbox w="80.0" h="40.0" x="19848.5" y="655.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s562_shh1_shh1_sa323"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: WD repeat domain 19 HUGO:WDR19 HGNC:18340 ENTREZ:57728 UNIPROT:Q8NEZ3 GENECARDS:WDR19 KEGG:57728 ATLASONC:GC_WDR19 WIKI:WDR19 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:12906858 References_end</body> </html> </notes> <label text="WDR19"/> <bbox w="80.0" h="40.0" x="19848.0" y="613.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s563_shh1_shh1_sa324"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Intraflagellar transport 122 homologue (Chlamydomonas) HUGO:IFT122 HGNC:13556 ENTREZ:55764 UNIPROT:Q9HBG6 GENECARDS:IFT122 KEGG:55764 WIKI:IFT122 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20889716 References_end</body> </html> </notes> <label text="IFT122"/> <bbox w="80.0" h="40.0" x="19765.0" y="655.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s564_shh1_shh1_sa325"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Intraflagellar transport 140 homologue (Chlamydomonas) HUGO:IFT140 HGNC:29077 ENTREZ:9742 UNIPROT:Q96RY7 GENECARDS:IFT140 KEGG:9742 WIKI:IFT140 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20889716 References_end</body> </html> </notes> <label text="IFT140"/> <bbox w="80.0" h="40.0" x="19765.0" y="613.0"/> </glyph> </glyph> <glyph class="phenotype" id="shh1_s_shh1_s479_shh1_shh1_sa268" compartmentRef="shh1_shh1_c6_shh1_shh1_ca6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re86(MAP:survival): PMID:11331587 PMID:16489008 s_wnc1_re141(MAP:survival): Activated Daam1 is responisble for the inhibition PMID:20351293 References_end</body> </html> </notes> <label text="Proliferation"/> <bbox w="80.0" h="30.0" x="19433.0" y="1906.0"/> </glyph> <glyph class="phenotype" id="shh1_s_shh1_s517_shh1_shh1_sa296" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <label text="PI3K AKT MTOR pathway"/> <clone/> <bbox w="80.0" h="30.0" x="18716.0" y="679.0"/> </glyph> <glyph class="phenotype" id="shh1_s_shh1_s517_shh1_shh3_sa56" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <label text="PI3K AKT MTOR pathway"/> <clone/> <bbox w="80.0" h="30.0" x="18855.0" y="5602.0"/> </glyph> <glyph class="phenotype" id="shh1_s_shh1_s514_shh1_shh1_sa293" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re98:(MAP:survival) PMID:18829525 References_end</body> </html> </notes> <label text="RAS activation"/> <bbox w="80.0" h="30.0" x="19459.0" y="2478.0"/> </glyph> <glyph class="phenotype" id="shh1_s_shh1_s477_shh1_shh1_sa266" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re84:(MAP:survival) The association of CyclinB and PTC occurs when cell is in G2/M arrest References_end</body> </html> </notes> <label text="G2_M phase arrest"/> <bbox w="80.0" h="30.0" x="19099.0" y="311.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s381_shh1_shh1_sa212" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 3 HUGO:GLI3 HGNC:4319 ENTREZ:2737 UNIPROT:P10071 GENECARDS:GLI3 KEGG:2737 ATLASONC:GC_GLI3 WIKI:GLI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI3-190*"/> <bbox w="165.0" h="41.0" x="18668.75" y="1618.7703"/> <glyph class="state variable" id="_690900b6-5671-42e8-8f11-4f23c6e51e3f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18695.76" y="1613.7703"/> </glyph> <glyph class="state variable" id="_1c6fc746-9913-4112-9297-f271f21f185c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18715.271" y="1613.7703"/> </glyph> <glyph class="state variable" id="_5724f301-da24-4062-b7f9-6c999c448bc0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18728.734" y="1613.7703"/> </glyph> <glyph class="state variable" id="_2e1c012c-3f6d-4bd0-94fc-83ac9ade081f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18767.105" y="1654.7703"/> </glyph> <glyph class="state variable" id="_17b4db8e-9c44-4eb9-8dd6-4d8aa28eaeb1"> <state value="P" variable="S860"/> <bbox w="35.0" h="10.0" x="18751.402" y="1613.7703"/> </glyph> <glyph class="state variable" id="_9d49b8ef-96de-4155-ab10-2d07b4832fed"> <state value="P" variable="S907"/> <bbox w="35.0" h="10.0" x="18698.637" y="1654.7703"/> </glyph> <glyph class="state variable" id="_5536a6c5-47cf-4f56-81ec-91a9e3034360"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="18690.76" y="1613.7703"/> </glyph> <glyph class="state variable" id="_73278471-9964-487c-808f-4f870474033d"> <state value="P" variable="S873"/> <bbox w="35.0" h="10.0" x="18816.25" y="1634.3356"/> </glyph> <glyph class="state variable" id="_3682dae8-e506-4677-b146-7eac7ae9399e"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="18710.271" y="1613.7703"/> </glyph> <glyph class="state variable" id="_9a4de724-1ecf-4092-a973-d1522a40ffa2"> <state value="P" variable="S849"/> <bbox w="35.0" h="10.0" x="18652.266" y="1613.7703"/> </glyph> <glyph class="state variable" id="_4087c727-2fd2-4015-863d-8284808d5837"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="18723.734" y="1613.7703"/> </glyph> <glyph class="state variable" id="_22a67f19-0cff-46b8-8f7a-498130735cc0"> <state value="P" variable="S868"/> <bbox w="35.0" h="10.0" x="18809.201" y="1613.7703"/> </glyph> <glyph class="state variable" id="_ae4b1170-c875-496c-bca2-28218b6dcf35"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="18762.105" y="1654.7703"/> </glyph> <glyph class="state variable" id="_ce25cfe0-e2a3-46fd-b31e-1e70eb0a65fb"> <state value="P" variable="S877"/> <bbox w="35.0" h="10.0" x="18814.975" y="1654.7703"/> </glyph> <glyph class="state variable" id="_400492c0-833e-4898-84a1-6b268c2ac285"> <state value="P" variable="S880"/> <bbox w="35.0" h="10.0" x="18772.35" y="1654.7703"/> </glyph> <glyph class="state variable" id="_80d23719-f92f-4229-be40-f9a6af01b748"> <state value="P" variable="S903"/> <bbox w="35.0" h="10.0" x="18735.203" y="1654.7703"/> </glyph> <glyph class="state variable" id="_8c2a2b06-e86f-4ebd-96c0-d45b66175609"> <state value="P" variable="S910"/> <bbox w="35.0" h="10.0" x="18651.744" y="1654.7703"/> </glyph> <glyph class="state variable" id="_21b0febb-8d55-483d-97d1-cb5793fa37c6"> <state value="P" variable="S852"/> <bbox w="35.0" h="10.0" x="18732.166" y="1613.7703"/> </glyph> <glyph class="state variable" id="_dd86a337-91db-42d0-8621-61e906cb34ea"> <state value="P" variable="S1006"/> <bbox w="40.0" h="10.0" x="18648.75" y="1628.7819"/> </glyph> <glyph class="state variable" id="_7a5d05d0-09cd-4320-bb51-b5f2c4a06568"> <state value="P" variable="S865"/> <bbox w="35.0" h="10.0" x="18768.707" y="1613.7703"/> </glyph> <glyph class="state variable" id="_bf3efb13-804b-4e3c-a759-091b5ae411c0"> <state value="P" variable="S980"/> <bbox w="35.0" h="10.0" x="18651.25" y="1636.5013"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s366_shh1_shh1_sa197" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re48(MAP:survival): PMID:20360384 PMID:19996169 PMID:18559511 s_wca1_re58(MAP:survival): PMID:21602792 In presence of WNT ligand References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Dynein cytoplasmic 2 heavy chain 1 HUGO:DYNC2H1 HGNC:2962 ENTREZ:79659 UNIPROT:Q8NCM8 GENECARDS:DYNC2H1 REACTOME:227754 KEGG:79659 ATLASONC:GC_DYNC2H1 WIKI:DYNC2H1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21209331 References_end Identifiers_begin: Dynein cytoplasmic 2 heavy chain 1 HUGO:DYNC2H1 HGNC:2962 ENTREZ:79659 UNIPROT:Q8NCM8 GENECARDS:DYNC2H1 REACTOME:227754 KEGG:79659 ATLASONC:GC_DYNC2H1 WIKI:DYNC2H1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21209331 References_end</body> </html> </notes> <label text="DYNC2H1"/> <bbox w="80.0" h="40.0" x="19705.0" y="1108.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s363_shh1_shh1_sa194" compartmentRef="shh1_shh1_c6_shh1_shh1_ca6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re51:(MAP:survival) PMID:20016067 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Protein kinase cAMP-depenedent catalytic alpha HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA Protein kinase cAMP-depenedent catalytic beta HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB Protein kinase cAMP-depenedent catalytic gamma HUGOPRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20027184 References_end</body> </html> </notes> <label text="PKA*"/> <bbox w="165.0" h="45.0" x="19217.5" y="1771.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s361_shh1_shh1_sa192" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re49(MAP:survival): PMID:20016067 the PTC receptor itself does not trigger the activation of PKA but the withdrawal of the SHH ligand does PMID:16537363 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: A kinase (PRKA) anchor protein 1 HUGO:AKAP1 HGNC:367 ENTREZ:8165 UNIPROT:Q92667 GENECARDS:AKAP1 REACTOME:49858 KEGG:8165 ATLASONC:GC_AKAP1 WIKI:AKAP1 A kinase (PRKA) anchor protein 2 HUGO:AKAP2 HGNC:372 ENTREZ:11217 UNIPROT:Q9Y2D5 GENECARDS:AKAP2 KEGG:11217 WIKI:AKAP2 A kinase (PRKA) anchor protein 3 HUGO:AKAP3 HGNC:373 ENTREZ:10566 UNIPROT:O75969 GENECARDS:AKAP3 KEGG:10566 ATLASONC:GC_AKAP3 WIKI:AKAP3 A kinase (PRKA) anchor protein 4 HUGO:AKAP4 HGNC:374 ENTREZ:8852 UNIPROT:Q5JQC9 GENECARDS:AKAP4 KEGG:8852 ATLASONC:GC_AKAP4 WIKI:AKAP4 A kinase (PRKA) anchor protein 5 HUGO:AKAP5 HGNC:375 ENTREZ:9495 UNIPROT:P24588 GENECARDS:AKAP5 REACTOME:381620 KEGG:9495 ATLASONC:GC_AKAP5 WIKI:AKAP5 A kinase (PRKA) anchor protein 6 HUGO:AKAP6 HGNC:376 ENTREZ:9472 UNIPROT:Q13023 GENECARDS:AKAP6 KEGG:9472 ATLASONC:GC_AKAP6 WIKI:AKAP6 A kinase (PRKA) anchor protein 7 HUGO:AKAP7 HGNC:377 ENTREZ:9465 UNIPROT:O43687 GENECARDS:AKAP7 KEGG:9465 ATLASONC:GC_AKAP7 WIKI:AKAP7 A kinase (PRKA) anchor protein 8 HUGO:AKAP8 HGNC:378 ENTREZ:10270 UNIPROT:O43823 GENECARDS:AKAP8 KEGG:10270 ATLASONC:GC_AKAP8 WIKI:AKAP8 A kinase (PRKA) anchor protein 9 HUGO:AKAP9 HGNC:379 ENTREZ:10142 UNIPROT:Q99996 GENECARDS:AKAP9 REACTOME:49844 KEGG:10142 ATLASONC:AKAP9ID42999ch7q21 WIKI:AKAP9 A kinase (PRKA) anchor protein 10 HUGO:AKAP10 HGNC:368 ENTREZ:11216 UNIPROT:O43572 GENECARDS:AKAP10 REACTOME:49822 KEGG:11216 ATLASONC:GC_AKAP10 WIKI:AKAP10 A kinase (PRKA) anchor protein 11 HUGOAKAP11 HGNC:369 ENTREZ:11215 UNIPROT:Q9UKA4 A kinase (PRKA) anchor protein 12 HUGO:AKAP12 HGNC:370 ENTREZ:9590 UNIPROT:Q02952 GENECARDS:AKAP12 KEGG:9590 ATLASONC:AKAP12ID607ch6q25 WIKI:AKAP12 A kinase (PRKA) anchor protein 13 HUGO:AKA13 GENECARDS:AKA13 WIKI:AKA13 A kinase (PRKA) anchor protein 14 HUGO:AKAP14 HGNC:24061 ENTREZ:158798 UNIPROT:Q86UN6 GENECARDS:AKAP14 KEGG:158798 WIKI:AKAP14 A kinase (PRKA) anchor protein 17 HUGO:AKAP17A HGNC:18783 ENTREZ:8227 UNIPROT:Q02040 GENECARDS:AKAP17A KEGG:8227 WIKI:AKAP17A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20016067 A kinase (PRKA) anchor protein References_end</body> </html> </notes> <label text="AKAP*"/> <bbox w="80.0" h="40.0" x="19365.5" y="894.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s334_shh1_shh1_sa186" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re44:(MAP:survival) PMID:20643644 s_shh1_re45(MAP:survival): PMID:20643644 PMID:19878745 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Unc-51-like kinase 3 HUGO:ULK3 HGNC:19703 ENTREZ:25989 UNIPROT:Q6PHR2 GENECARDS:ULK3 ATLASONC:GC_ULK3 WIKI:ULK3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Unc-51-like kinase PMID:20643644 PMID:19878745 References_end</body> </html> </notes> <label text="ULK3"/> <bbox w="80.0" h="40.0" x="19440.916" y="795.668"/> <glyph class="state variable" id="_42fc0fe4-7658-4d1e-817e-744c911c0c68"> <state value="P" variable="S384"/> <bbox w="35.0" h="10.0" x="19502.797" y="830.668"/> </glyph> <glyph class="state variable" id="_17f420ef-c761-47f1-999f-640f313f4c26"> <state value="P" variable="S464"/> <bbox w="35.0" h="10.0" x="19423.416" y="830.3903"/> </glyph> <glyph class="state variable" id="_7f178a68-1335-45d6-8500-c018ded24776"> <state value="P" variable="S300"/> <bbox w="35.0" h="10.0" x="19423.908" y="790.668"/> </glyph> <glyph class="state variable" id="_d9d9dfa7-5a21-417c-a0c3-6500399bd0fd"> <state value="P" variable="S350"/> <bbox w="35.0" h="10.0" x="19503.416" y="790.8828"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s302_shh1_shh1_sa3" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re38(MAP:survival): PMID:20956384 PMID:21209912 PMID:19549984 PMID:19592253 s_shh1_re40(MAP:survival): PMID:20643644 s_shh1_re52:(MAP:survival) PMID:20016067 s_shh1_re92:(MAP:survival) PMID:18997815 s_shh1_re101:(MAP:survival) PMID:17688959 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Smoothened HUGO:SMO HGNC:11119 ENTREZ:6608 UNIPROT:Q99835 GENECARDS:SMO REACTOME:64670 KEGG:6608 ATLASONC:GC_SMO WIKI:SMO Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18820483 PMID:17641202 Smoothened homologue (Drosophila) References_end</body> </html> </notes> <label text="SMO"/> <bbox w="80.0" h="40.0" x="19793.0" y="150.75"/> <glyph class="state variable" id="_35895cdd-7212-472a-929b-7986686353a2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19868.0" y="145.75"/> </glyph> <glyph class="state variable" id="_56cfa844-0392-4d33-9338-7afed48e9b6f"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="19865.5" y="145.75"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s287_shh1_shh1_sa146" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re33:(MAP:survival) PMID:18497258 s_mpk1_re61(MAP:survival): Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN. PMID:11226259 s_wca1_re29(MAP:survival): PMID:19705439 PMID:17426148 Beta-ARRESTIN binds to phosphorylated DVL s_wca1_re45:(MAP:survival) PMID:20460648 PMID:18077588 PMID:19705439 PMID:17426148 s_wnc1_re70:(MAP:survival) PMID:12958364 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="18672.75" y="277.25"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s285_shh1_shh1_sa350" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re115(MAP:survival): PMID:12764189 PMID:18815277 s_mpk1_re85(MAP:survival): Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN. PMID:11226259 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: adrenergic beta receptor kinase 1 HUGO:ADRBK1 HGNC:289 ENTREZ:156 UNIPROT:P25098 adrenergic beta receptor kinase 2 HUGO:ADRBK2 HGNC:290 ENTREZ:157 UNIPROT:P35626 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN. PMID:11226259 References_end Identifiers_begin: G protein-coupled receptor kinase 1 HUGO:GRK1 HGNC:10013 ENTREZ:6011 UNIPROT:Q15835 GENECARDS:GRK1 KEGG:6011 ATLASONC:GC_GRK1 WIKI:GRK1 G protein-coupled receptor kinase 4 HUGO:GRK4 HGNC:4543 ENTREZ:2868 UNIPROT:P32298 GENECARDS:GRK4 KEGG:2868 ATLASONC:GC_GRK4 WIKI:GRK4 G protein-coupled receptor kinase 5 HUGO:GRK5 HGNC:4544 ENTREZ:2869 UNIPROT:P34947 GENECARDS:GRK5 REACTOME:55956 KEGG:2869 WIKI:GRK5 G protein-coupled receptor kinase 6 HUGO:GRK6 HGNC:4545 ENTREZ:2870 UNIPROT:P43250 GENECARDS:GRK6 KEGG:2870 ATLASONC:GC_GRK6 WIKI:GRK6 G protein-coupled receptor kinase 7 HUGO:GRK7 HGNC:17031 ENTREZ:131890 UNIPROT:Q8WTQ7 GENECARDS:GRK7 KEGG:131890 WIKI:GRK7 adrenergic beta receptor kinase 1 HUGO:ADRBK1 HGNC:289 ENTREZ:156 UNIPROT:P25098 GENECARDS:ADRBK1 REACTOME:50271 KEGG:156 ATLASONC:GC_ADRBK1 WIKI:ADRBK1 adrenergic beta receptor kinase 2 HUGO:ADRBK2 HGNC:290 ENTREZ:157 UNIPROT:P35626 GENECARDS:ADRBK2 KEGG:157 ATLASONC:GC_ADRBK2 WIKI:ADRBK2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK Maps_Modules_end References_begin: PMID:16525728 PMID:15618519 Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN. PMID:11226259 References_end</body> </html> </notes> <label text="GRK*"/> <clone/> <bbox w="80.0" h="40.0" x="18105.5" y="265.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s285_shh1_shh3_sa47" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re115(MAP:survival): PMID:12764189 PMID:18815277 s_mpk1_re85(MAP:survival): Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN. PMID:11226259 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: adrenergic beta receptor kinase 1 HUGO:ADRBK1 HGNC:289 ENTREZ:156 UNIPROT:P25098 adrenergic beta receptor kinase 2 HUGO:ADRBK2 HGNC:290 ENTREZ:157 UNIPROT:P35626 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN. PMID:11226259 References_end Identifiers_begin: G protein-coupled receptor kinase 1 HUGO:GRK1 HGNC:10013 ENTREZ:6011 UNIPROT:Q15835 GENECARDS:GRK1 KEGG:6011 ATLASONC:GC_GRK1 WIKI:GRK1 G protein-coupled receptor kinase 4 HUGO:GRK4 HGNC:4543 ENTREZ:2868 UNIPROT:P32298 GENECARDS:GRK4 KEGG:2868 ATLASONC:GC_GRK4 WIKI:GRK4 G protein-coupled receptor kinase 5 HUGO:GRK5 HGNC:4544 ENTREZ:2869 UNIPROT:P34947 GENECARDS:GRK5 REACTOME:55956 KEGG:2869 WIKI:GRK5 G protein-coupled receptor kinase 6 HUGO:GRK6 HGNC:4545 ENTREZ:2870 UNIPROT:P43250 GENECARDS:GRK6 KEGG:2870 ATLASONC:GC_GRK6 WIKI:GRK6 G protein-coupled receptor kinase 7 HUGO:GRK7 HGNC:17031 ENTREZ:131890 UNIPROT:Q8WTQ7 GENECARDS:GRK7 KEGG:131890 WIKI:GRK7 adrenergic beta receptor kinase 1 HUGO:ADRBK1 HGNC:289 ENTREZ:156 UNIPROT:P25098 GENECARDS:ADRBK1 REACTOME:50271 KEGG:156 ATLASONC:GC_ADRBK1 WIKI:ADRBK1 adrenergic beta receptor kinase 2 HUGO:ADRBK2 HGNC:290 ENTREZ:157 UNIPROT:P35626 GENECARDS:ADRBK2 KEGG:157 ATLASONC:GC_ADRBK2 WIKI:ADRBK2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK Maps_Modules_end References_begin: PMID:16525728 PMID:15618519 Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN. PMID:11226259 References_end</body> </html> </notes> <label text="GRK*"/> <clone/> <bbox w="80.0" h="40.0" x="18380.0" y="5420.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s284_shh1_shh1_sa143" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re28:(MAP:survival) PMID:15618519 s_shh3_re8(MAP:survival): PMID:18815277 PMID:16885213 s_shh1_re33:(MAP:survival) PMID:18497258 s_shh3_re13:(MAP:survival) PMID:12514186 PMID:18359851 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Smoothened HUGO:SMO HGNC:11119 ENTREZ:6608 UNIPROT:Q99835 GENECARDS:SMO REACTOME:64670 KEGG:6608 ATLASONC:GC_SMO WIKI:SMO Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18820483 PMID:17641202 Smoothened homologue (Drosophila) References_end</body> </html> </notes> <label text="SMO"/> <bbox w="80.0" h="40.0" x="18637.5" y="426.0"/> <glyph class="state variable" id="_6a9c882a-6f0c-4aa0-af92-8f2a3fbe92ed"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18712.5" y="421.0"/> </glyph> <glyph class="state variable" id="_fa9ce358-7205-475b-b9c6-68e83a87445b"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="18710.0" y="421.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s283_shh1_shh1_sa142" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re27:(MAP:survival) PMID:17430994 s_shh1_re28:(MAP:survival) PMID:15618519 s_shh2_re121(MAP:survival): PMID:20564213 ANNOTATION: Not clear how suprresion is regulated by Hedgehog s_shh2_re122:(MAP:survival) PMID:19351822 s_shh3_re8(MAP:survival): PMID:18815277 PMID:16885213 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Smoothened HUGO:SMO HGNC:11119 ENTREZ:6608 UNIPROT:Q99835 GENECARDS:SMO REACTOME:64670 KEGG:6608 ATLASONC:GC_SMO WIKI:SMO Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18820483 PMID:17641202 Smoothened homologue (Drosophila) References_end</body> </html> </notes> <label text="SMO"/> <clone/> <bbox w="80.0" h="40.0" x="18478.625" y="425.5"/> <glyph class="state variable" id="_3346096f-e4fa-40d7-8c5e-52d1a55e0b8b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18553.625" y="420.5"/> </glyph> <glyph class="state variable" id="_d82ec12e-b96f-46d1-bdec-f80483016cf8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18553.625" y="420.5"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s283_shh1_shh3_sa43" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re27:(MAP:survival) PMID:17430994 s_shh1_re28:(MAP:survival) PMID:15618519 s_shh2_re121(MAP:survival): PMID:20564213 ANNOTATION: Not clear how suprresion is regulated by Hedgehog s_shh2_re122:(MAP:survival) PMID:19351822 s_shh3_re8(MAP:survival): PMID:18815277 PMID:16885213 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Smoothened HUGO:SMO HGNC:11119 ENTREZ:6608 UNIPROT:Q99835 GENECARDS:SMO REACTOME:64670 KEGG:6608 ATLASONC:GC_SMO WIKI:SMO Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18820483 PMID:17641202 Smoothened homologue (Drosophila) References_end</body> </html> </notes> <label text="SMO"/> <clone/> <bbox w="80.0" h="40.0" x="18426.5" y="5221.0"/> <glyph class="state variable" id="_def4e4c4-9cb0-4f28-a305-86a88f838fd3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18501.5" y="5216.0"/> </glyph> <glyph class="state variable" id="_0fd52bd3-f085-4ee6-a541-aeb9bbce1cd9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18501.5" y="5216.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s259_shh1_shh1_sa130" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re36(MAP:survival): PMID:20956384 PMID:19592253 PMID:0643644 s_shh1_re68:(MAP:survival) PMID:18455992 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 2 HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Glioma-associated oncogene family zinc finger PMID:18497536 PMID:17845852 PMID:11001584 References_end</body> </html> </notes> <label text="GLI2-185*"/> <bbox w="165.0" h="39.0" x="18005.0" y="634.0"/> <glyph class="state variable" id="_da0c4dea-2e44-434c-8ab9-93804d460c76"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18055.232" y="629.0"/> </glyph> <glyph class="state variable" id="_ab44502d-4b88-4162-971a-c84fc2310c6b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18096.729" y="629.0"/> </glyph> <glyph class="state variable" id="_c7bf4ef9-5a82-4e67-b088-8f17b76cce14"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18103.355" y="668.0"/> </glyph> <glyph class="state variable" id="_6d9e51f2-1847-4336-a967-142f9c259c42"> <state value="" variable="S801"/> <bbox w="30.0" h="10.0" x="18058.406" y="629.0"/> </glyph> <glyph class="state variable" id="_0ba18695-3a7d-478f-838f-05d8ef8d95cf"> <state value="" variable="K757"/> <bbox w="30.0" h="10.0" x="17990.0" y="641.1247"/> </glyph> <glyph class="state variable" id="_16953eba-e53f-4a6b-bd14-b6c4fc5281e7"> <state value="" variable="S956"/> <bbox w="30.0" h="10.0" x="17990.0" y="667.72925"/> </glyph> <glyph class="state variable" id="_b3771977-5a6b-4a75-9dfb-3a02d5759b6c"> <state value="" variable="S817"/> <bbox w="30.0" h="10.0" x="18153.725" y="668.0"/> </glyph> <glyph class="state variable" id="_ef62c3b7-f8f2-4b47-9e03-6ea3a8a81ffc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18082.5" y="629.0"/> </glyph> <glyph class="state variable" id="_9c527abf-8754-4068-83fd-ff50debacc2a"> <state value="" variable="S847"/> <bbox w="30.0" h="10.0" x="18041.22" y="668.0"/> </glyph> <glyph class="state variable" id="_054af1ab-5918-4a8b-8e86-9b466af8259b"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="17990.0" y="648.46893"/> </glyph> <glyph class="state variable" id="_4f12f880-d69a-43e0-8bfb-fa0a509f4326"> <state value="" variable="S789"/> <bbox w="30.0" h="10.0" x="17990.0" y="640.6754"/> </glyph> <glyph class="state variable" id="_da98dc29-9a28-4f79-9c36-e4642c52fb27"> <state value="" variable="S1011"/> <bbox w="35.0" h="10.0" x="17987.5" y="655.363"/> </glyph> <glyph class="state variable" id="_2452bfb2-30fd-4d65-8421-8b1af84f1301"> <state value="" variable="S805"/> <bbox w="30.0" h="10.0" x="18093.635" y="629.0"/> </glyph> <glyph class="state variable" id="_1e7870bf-bf00-4bd5-bf00-b44ce88d7c29"> <state value="" variable="S820"/> <bbox w="30.0" h="10.0" x="18118.389" y="668.0"/> </glyph> <glyph class="state variable" id="_df3a6553-1184-4693-ad68-307b3385b4ce"> <state value="" variable="S813"/> <bbox w="30.0" h="10.0" x="18155.0" y="648.56213"/> </glyph> <glyph class="state variable" id="_5ad275e7-bd48-4f9e-9ef9-a277ce5007c0"> <state value="" variable="S850"/> <bbox w="30.0" h="10.0" x="17990.0" y="666.9748"/> </glyph> <glyph class="state variable" id="_b18c9320-c242-402c-90e5-739e19ce3267"> <state value="" variable="S844"/> <bbox w="30.0" h="10.0" x="18067.346" y="668.0"/> </glyph> <glyph class="state variable" id="_49fd902f-278f-4d53-a74b-d2a73e1fcec2"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="17991.016" y="629.0"/> </glyph> <glyph class="state variable" id="_358b577b-b5d9-44a1-a799-32fe0a8ae7d6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18103.355" y="668.0"/> </glyph> <glyph class="state variable" id="_944ff27f-36d4-4bda-bf2c-4ae4bf3aafac"> <state value="" variable="S808"/> <bbox w="30.0" h="10.0" x="18154.244" y="629.0"/> </glyph> <glyph class="state variable" id="_058b12c2-b555-49f5-beef-cb226258055b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18043.74" y="629.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s256_shh1_shh1_sa127" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re56:(MAP:survival) PMID:16371461 s_shh1_re61:(MAP:survival) PMID:16611981 s_shh1_re71(MAP:survival): PMID:18455992 PMID:16611981 s_akt1_re70:(MAP:survival) PMID:21233202 s_akt1_re159:(MAP:survival) PMID:19797085 s_wca2_re55:(MAP:survival) PMID:21536646 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end Identifiers_begin: casein kinase 1 alpha 1 HUGO:CSNK1A1 HGNC:2451 ENTREZ:1452 UNIPROT:P48729 GENECARDS:CSNK1A1 REACTOME:57867 KEGG:1452 ATLASONC:CSNK1A1ID40168ch5q32 WIKI:CSNK1A1 P48729 casein kinase 1 delta HUGO:CSNK1D HGNC:2452 ENTREZ:1453 UNIPROT:P48730 GENECARDS:CSNK1D REACTOME:57869 KEGG:1453 ATLASONC:GC_CSNK1D WIKI:CSNK1D P48730 casein kinase 1 epsilon HUGO:CSNK1E HGNC:2453 ENTREZ:1454 UNIPROT:P49674 GENECARDS:CSNK1E REACTOME:57871 KEGG:1454 ATLASONC:GC_CSNK1E WIKI:CSNK1E P49674 casein kinase 1 gamma 1 HUGO:CSNK1G1 HGNC:2454 ENTREZ:53944 UNIPROT:Q9HCP0 GENECARDS:CSNK1G1 KEGG:53944 ATLASONC:GC_CSNK1G1 WIKI:CSNK1G1 Q9HCP0 casein kinase 1 gamma 2 HUGO:CSNK1G2 HGNC:2455 ENTREZ:1455 UNIPROT:P78368 GENECARDS:CSNK1G2 REACTOME:57863 KEGG:1455 ATLASONC:GC_CSNK1G2 WIKI:CSNK1G2 P78368 casein kinase 1 gamma 3 HUGO:CSNK1G3 HGNC:2456 ENTREZ:1456 UNIPROT:Q9Y6M4 GENECARDS:CSNK1G3 KEGG:1456 ATLASONC:GC_CSNK1G3 WIKI:CSNK1G3 Q9Y6M4 casein kinase 1 epsiHUGO:CSNK1E HGNC:2453 ENTREZ:1454 P49674 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:7641885 casein kinase 1 PMID:21233202 References_end</body> </html> </notes> <label text="CK1*"/> <bbox w="80.0" h="40.0" x="18682.5" y="769.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s255_shh1_shh1_sa126" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re56:(MAP:survival) PMID:16371461 s_shh1_re61:(MAP:survival) PMID:16611981 s_shh1_re71(MAP:survival): PMID:18455992 PMID:16611981 s_shh1_re99(MAP:survival): PMID:19575820 PMID:17052453 s_mpk1_re105(MAP:survival): Phosphorylation of beta-catenin (CTNNB1) by GSK-3beta (GSK3B) causes its degradation PMID:16039586 s_mpk1_re109(MAP:survival): ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. s_mpk1_re110(MAP:survival): A small fraction of both ERK and GSK3 is constitutively found in a protease-protected mitochondrial compartment. How this fraction of ERK and GSK3 enters mitochondria is an open question. PMID:20080742 s_mpk1_re271(MAP:survival): Glycogen synthase kinase 3 (GSK3) is a target of Akt. This protein kinase is constitutively active in unstimulated cells and phosphorylates many proteins (including glycogen synthase C-MYC and cyclin D) to keep them in inactive states or promote their degradation. Phosphorylation of GSK3 (both alpha and beta isoforms) by Akt turns off the catalytic activity of this enzyme resulting in the activation of pathways that are normally repressed by GSK3. PMID:12040186 s_mpk1_re279(MAP:survival): MAX interacts with the transcription factor C-MYC enabling C-MYC to trans-activate at least a subset of its target genes. GSK3 is constitutively active in unstimulated cells and phosphorylates many proteins (including glycogen synthase C-MYC and cyclin D) to keep them in inactive states or promote their degradation. PMID:11274345 PMID:12040186 s_akt1_re82(MAP:survival): PMID:17444818 ANNOTATION:PTEN is destabilized by phosphorylation on T366 followed by phosphorylation on S370 by GSK3beta. s_akt1_re160:(MAP:survival) PMID:19797085 s_wca2_re54:(MAP:survival) PMID:10671551 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end</body> </html> </notes> <label text="GSK3β*"/> <bbox w="80.0" h="40.0" x="18790.5" y="770.0"/> <glyph class="state variable" id="_87c77edd-97e0-4502-b7f6-a28a9b082263"> <state value="" variable="S9"/> <bbox w="20.0" h="10.0" x="18780.992" y="765.0"/> </glyph> <glyph class="state variable" id="_ca987702-291a-44c7-a84d-e2c04ab0efb2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18785.5" y="785.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s158_shh1_shh1_sa69" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re20(MAP:survival): PMID17283082. A domain in the a.a. sequence favors the truncation of the protein References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 3 HUGO:GLI3 HGNC:4319 ENTREZ:2737 UNIPROT:P10071 GENECARDS:GLI3 KEGG:2737 ATLASONC:GC_GLI3 WIKI:GLI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI3-83TRUNC*"/> <bbox w="80.0" h="40.0" x="18431.0" y="1976.0"/> <glyph class="unit of information" id="_83f367b6-8792-44bc-9ead-f2998d13ffd5"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="18446.0" y="1971.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s153_shh1_shh1_sa67" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re11(MAP:survival): PMID:17283082 PMID:19147008 GLI2 ompletely degraded no truncated form present PMID:16611981 Truncated form of GLI2 is produced References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 2 HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Glioma-associated oncogene family zinc finger PMID:18497536 PMID:17845852 PMID:11001584 References_end</body> </html> </notes> <label text="GLI2-78TRUNC*"/> <bbox w="80.0" h="40.0" x="18002.0" y="1976.0"/> <glyph class="unit of information" id="_75a68336-2cfe-4ff2-8b9e-2af0b2db3667"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="18017.0" y="1971.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s96_shh1_shh1_sa51" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: E2 ENZYME s_shh1_re59(MAP:survival): PMID:16371461 PMID:16651270 Gli3 ubi by bTrCP1 PMID:18813803 s_shh1_re64(MAP:survival): PMID:16611981 Gli2 ubi by bTrCP2 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: CDC34 HUGO:CDC34 HGNC:1734 ENTREZ:997 UNIPROT:P49427 GENECARDS:CDC34 REACTOME:66737 KEGG:997 ATLASONC:GC_CDC34 WIKI:CDC34 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17329932 PMID:9367342 References_end Identifiers_begin: CDC34 HUGO:CDC34 HGNC:1734 ENTREZ:997 UNIPROT:P49427 GENECARDS:CDC34 REACTOME:66737 KEGG:997 ATLASONC:GC_CDC34 WIKI:CDC34 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17329932 PMID:9367342 References_end</body> </html> </notes> <label text="CDC34"/> <bbox w="80.0" h="40.0" x="18824.0" y="1123.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s1_shh1_shh1_sa1" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re85:(MAP:survival) PMID:11331587 s_shh1_re49(MAP:survival): PMID:20016067 the PTC receptor itself does not trigger the activation of PKA but the withdrawal of the SHH ligand does PMID:16537363 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Patched 1 HUGO:PTCH1 HGNC:9585 ENTREZ:5727 UNIPROT:Q13635 GENECARDS:PTCH1 REACTOME:62393 KEGG:5727 ATLASONC:PTCH100 WIKI:PTCH1 Patched 2 HUGO:PTCH2 HGNC:9586 ENTREZ:8643 UNIPROT:Q9Y6C5 GENECARDS:PTCH2 REACTOME:62395 KEGG:8643 ATLASONC:PTCH2ID41892ch1p34 WIKI:PTCH2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:10021362 PMID:17641202 References_end</body> </html> </notes> <label text="PTCH*"/> <bbox w="78.0" h="114.0" x="19256.0" y="115.0"/> <glyph class="unit of information" id="_6623b3ac-4692-4bd8-a49d-723dd0b4dcc9"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="19272.5" y="110.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s399_shh1_shh1_sa229" compartmentRef="shh1_shh1_c6_shh1_shh1_ca6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 3 HUGO:GLI3 HGNC:4319 ENTREZ:2737 UNIPROT:P10071 GENECARDS:GLI3 KEGG:2737 ATLASONC:GC_GLI3 WIKI:GLI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI3-83TRUNC*"/> <bbox w="80.0" h="40.0" x="19283.5" y="1981.0"/> <glyph class="unit of information" id="_108c8e1c-971c-47f0-ae1b-934a2879e7da"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="19298.5" y="1976.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s412_shh1_shh1_sa228" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re63(MAP:survival): PMID:16611981 Proteolytic degradation is very inefficient therefore more ful-length Gli2 present References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 2 HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Glioma-associated oncogene family zinc finger PMID:18497536 PMID:17845852 PMID:11001584 References_end</body> </html> </notes> <label text="GLI2-185*"/> <bbox w="162.0" h="38.0" x="18102.25" y="1368.0"/> <glyph class="state variable" id="_3f764d15-c924-4786-84c5-8ac34db0cbb2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18151.479" y="1363.0"/> </glyph> <glyph class="state variable" id="_891ef148-c0a9-4fd2-b422-e333f2426af6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18192.22" y="1363.0"/> </glyph> <glyph class="state variable" id="_7c3d1533-d4b0-404f-a39a-2ee76e1057f4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18198.727" y="1401.0"/> </glyph> <glyph class="state variable" id="_86e4380e-5231-4666-ad46-4a12d3630739"> <state value="P" variable="S801"/> <bbox w="35.0" h="10.0" x="18151.912" y="1363.0"/> </glyph> <glyph class="state variable" id="_06731f13-6b08-4659-abe5-4a9b4191b614"> <state value="" variable="K757"/> <bbox w="30.0" h="10.0" x="18087.25" y="1374.8137"/> </glyph> <glyph class="state variable" id="_269a385c-a4ee-4c99-b534-6154fb384d16"> <state value="" variable="S956"/> <bbox w="30.0" h="10.0" x="18087.25" y="1400.7362"/> </glyph> <glyph class="state variable" id="_c6277921-30a7-4360-8ea0-99ef9c2afe11"> <state value="P" variable="S817"/> <bbox w="35.0" h="10.0" x="18245.498" y="1401.0"/> </glyph> <glyph class="state variable" id="_2e9f2759-d499-46d0-ba33-fdb96ef6165e"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="18173.25" y="1363.0"/> </glyph> <glyph class="state variable" id="_10a06a06-40b8-45bb-bf03-974a69824333"> <state value="P" variable="S847"/> <bbox w="35.0" h="10.0" x="18135.041" y="1401.0"/> </glyph> <glyph class="state variable" id="_81272a74-6111-40e8-a2a3-be9f0e848c3b"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="18087.25" y="1381.9697"/> </glyph> <glyph class="state variable" id="_75ae577e-e43d-48f5-a62b-bede9c2948f6"> <state value="P" variable="S789"/> <bbox w="35.0" h="10.0" x="18084.75" y="1374.3761"/> </glyph> <glyph class="state variable" id="_0ac6c5d3-0740-4796-abee-8ad67deda6d7"> <state value="" variable="S1011"/> <bbox w="35.0" h="10.0" x="18084.75" y="1388.687"/> </glyph> <glyph class="state variable" id="_e810be5b-2169-4f39-b34b-57d7b5fdc352"> <state value="P" variable="S805"/> <bbox w="35.0" h="10.0" x="18186.502" y="1363.0"/> </glyph> <glyph class="state variable" id="_6b8ec6b7-9f8c-4d99-93a0-0a2a97ef8884"> <state value="P" variable="S820"/> <bbox w="35.0" h="10.0" x="18210.805" y="1401.0"/> </glyph> <glyph class="state variable" id="_443cadd0-7e1c-402a-ba16-76facd222c5a"> <state value="P" variable="S813"/> <bbox w="35.0" h="10.0" x="18246.75" y="1382.0605"/> </glyph> <glyph class="state variable" id="_f0d44c9a-834d-4812-b2d1-39cd034235ed"> <state value="P" variable="S850"/> <bbox w="35.0" h="10.0" x="18084.75" y="1400.0011"/> </glyph> <glyph class="state variable" id="_acc6cd13-4280-405d-8dbe-252307413e28"> <state value="P" variable="S844"/> <bbox w="35.0" h="10.0" x="18160.69" y="1401.0"/> </glyph> <glyph class="state variable" id="_ec46d32f-debf-4d01-8667-6128c3465bff"> <state value="P" variable="S792"/> <bbox w="35.0" h="10.0" x="18085.748" y="1363.0"/> </glyph> <glyph class="state variable" id="_0c8bb0b6-586e-4284-80c9-1638aa9ae2d9"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="18196.227" y="1401.0"/> </glyph> <glyph class="state variable" id="_43e31ffe-0bab-44c3-9264-739aa912dcbd"> <state value="P" variable="S808"/> <bbox w="35.0" h="10.0" x="18246.008" y="1363.0"/> </glyph> <glyph class="state variable" id="_c62577fe-6b5a-4cdc-9560-2527880959be"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="18135.195" y="1363.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s413_shh1_shh1_sa65" compartmentRef="shh1_shh1_c3_shh1_shh1_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re63(MAP:survival): PMID:16611981 Proteolytic degradation is very inefficient therefore more ful-length Gli2 present s_shh1_re11(MAP:survival): PMID:17283082 PMID:19147008 GLI2 ompletely degraded no truncated form present Truncated form of GLI2 is produced References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 2 HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Glioma-associated oncogene family zinc finger PMID:18497536 PMID:17845852 PMID:11001584 References_end</body> </html> </notes> <label text="GLI2-185*"/> <bbox w="165.0" h="41.0" x="18086.25" y="1619.0538"/> <glyph class="state variable" id="_8e93654b-abd6-4c72-a991-d8d8daf43475"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18136.482" y="1614.0538"/> </glyph> <glyph class="state variable" id="_2d2120bd-8a11-4be0-8b73-710ecc9e3688"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18177.979" y="1614.0538"/> </glyph> <glyph class="state variable" id="_fcc23beb-d5e7-408e-b8a9-61cad9d04275"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18184.605" y="1655.0538"/> </glyph> <glyph class="state variable" id="_9548b5cd-1630-44bd-9302-9b1f6dce412c"> <state value="P" variable="S801"/> <bbox w="35.0" h="10.0" x="18137.156" y="1614.0538"/> </glyph> <glyph class="state variable" id="_e53d091e-2a90-4ddc-9e0b-cadc060f2f33"> <state value="" variable="K757"/> <bbox w="30.0" h="10.0" x="18071.25" y="1626.8003"/> </glyph> <glyph class="state variable" id="_1992773a-f625-45ac-86c7-9c04f0d08456"> <state value="" variable="S956"/> <bbox w="30.0" h="10.0" x="18071.25" y="1654.7692"/> </glyph> <glyph class="state variable" id="_d6ed7ef5-79e5-4e81-b16a-9f8ebab6947a"> <state value="P" variable="S817"/> <bbox w="35.0" h="10.0" x="18232.475" y="1655.0538"/> </glyph> <glyph class="state variable" id="_d35dee4e-bea6-439d-aad7-106a41965e8d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18163.75" y="1614.0538"/> </glyph> <glyph class="state variable" id="_8179b257-01c9-4b80-a629-4b7e0ced16bd"> <state value="P" variable="S847"/> <bbox w="35.0" h="10.0" x="18119.97" y="1655.0538"/> </glyph> <glyph class="state variable" id="_de26efc0-190d-4b74-991e-907f5b30570c"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="18071.25" y="1634.5212"/> </glyph> <glyph class="state variable" id="_bf0df46a-7bf0-47b4-9c5b-2c62575fec50"> <state value="P" variable="S789"/> <bbox w="35.0" h="10.0" x="18068.75" y="1626.328"/> </glyph> <glyph class="state variable" id="_8f87266d-d085-42f2-9098-6dead1bf53ec"> <state value="" variable="S1011"/> <bbox w="35.0" h="10.0" x="18068.75" y="1641.7687"/> </glyph> <glyph class="state variable" id="_326404a5-b6ae-423c-8373-46d8c4ae2644"> <state value="P" variable="S805"/> <bbox w="35.0" h="10.0" x="18172.385" y="1614.0538"/> </glyph> <glyph class="state variable" id="_35956b89-03a2-42fc-a7e3-b0cd15a2974c"> <state value="P" variable="S820"/> <bbox w="35.0" h="10.0" x="18197.139" y="1655.0538"/> </glyph> <glyph class="state variable" id="_a9dc484d-ecc4-4569-983d-63f890edefd0"> <state value="P" variable="S813"/> <bbox w="35.0" h="10.0" x="18233.75" y="1634.6191"/> </glyph> <glyph class="state variable" id="_51990578-4a99-457f-b2b3-c3240823432c"> <state value="P" variable="S850"/> <bbox w="35.0" h="10.0" x="18068.75" y="1653.9761"/> </glyph> <glyph class="state variable" id="_afa932ca-f2e7-4e58-acff-c23b7160eef5"> <state value="P" variable="S844"/> <bbox w="35.0" h="10.0" x="18146.096" y="1655.0538"/> </glyph> <glyph class="state variable" id="_ebb017eb-eae3-4d0a-bcba-33f573b3d32d"> <state value="P" variable="S792"/> <bbox w="35.0" h="10.0" x="18069.766" y="1614.0538"/> </glyph> <glyph class="state variable" id="_013e3ad7-8fad-4ee5-8643-96b2bc1e557f"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="18182.105" y="1655.0538"/> </glyph> <glyph class="state variable" id="_7ea89234-c0bf-4d1d-a296-562e0323bda9"> <state value="P" variable="S808"/> <bbox w="35.0" h="10.0" x="18232.994" y="1614.0538"/> </glyph> <glyph class="state variable" id="_ab98b7d9-1391-4aa0-925d-1e0048d4d252"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="18119.99" y="1614.0538"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s430_shh1_shh1_sa242" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wnc2_re46(MAP:survival): Upon Ca2+ activation the NRON-NFAT complex dissociates. PMID:21709260 s_shh1_re70:(MAP:survival) PMID:18455992 s_wnc2_re61(MAP:survival): DYRK1A-mediated phosphorylation PMID:21965663 s_wnc2_re62:(MAP:survival) PMID:21965663, PMID:12063245 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A HUGO:DYRK1A HGNC:3091 ENTREZ:1859 UNIPROT:Q13627 GENECARDS:DYRK1A REACTOME:54046 KEGG:1859 ATLASONC:DYRK1AID43234ch21q22 WIKI:DYRK1A 1859 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B HUGO:DYRK1B HGNC:3092 ENTREZ:9149 UNIPROT:Q9Y463 GENECARDS:DYRK1B KEGG:9149 ATLASONC:DYRK1BID43235ch19q13 WIKI:DYRK1B 9149 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 HUGO:DYRK2 HGNC:3093 ENTREZ:8445 UNIPROT:Q92630 GENECARDS:DYRK2 ATLASONC:GC_DYRK2 WIKI:DYRK2 8445 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 HUGO:DYRK3 HGNC:3094 ENTREZ:8444 UNIPROT:O43781 GENECARDS:DYRK3 KEGG:8444 ATLASONC:GC_DYRK3 WIKI:DYRK3 8444 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 HUGO:DYRK4 HGNC:3095 ENTREZ:8798 UNIPROT:Q9NR20 GENECARDS:DYRK4 ATLASONC:GC_DYRK4 WIKI:DYRK4 8798 DYRK, DYRK1, MNBH Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:9932450 PMID:19685005 References_end Identifiers_begin: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A HUGO:DYRK1A HGNC:3091 ENTREZ:1859 UNIPROT:Q13627 GENECARDS:DYRK1A REACTOME:54046 KEGG:1859 ATLASONC:DYRK1AID43234ch21q22 WIKI:DYRK1A 1859 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B HUGO:DYRK1B HGNC:3092 ENTREZ:9149 UNIPROT:Q9Y463 GENECARDS:DYRK1B KEGG:9149 ATLASONC:DYRK1BID43235ch19q13 WIKI:DYRK1B 9149 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 HUGO:DYRK2 HGNC:3093 ENTREZ:8445 UNIPROT:Q92630 GENECARDS:DYRK2 ATLASONC:GC_DYRK2 WIKI:DYRK2 8445 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 HUGO:DYRK3 HGNC:3094 ENTREZ:8444 UNIPROT:O43781 GENECARDS:DYRK3 KEGG:8444 ATLASONC:GC_DYRK3 WIKI:DYRK3 8444 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 HUGO:DYRK4 HGNC:3095 ENTREZ:8798 UNIPROT:Q9NR20 GENECARDS:DYRK4 ATLASONC:GC_DYRK4 WIKI:DYRK4 8798 DYRK, DYRK1, MNBH Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:9932450 PMID:19685005 References_end</body> </html> </notes> <label text="DYRK*"/> <bbox w="80.0" h="40.0" x="18797.0" y="2174.0"/> <glyph class="state variable" id="_0e8e72a7-8788-4057-91fd-f0259de14701"> <state value="" variable="T308"/> <bbox w="30.0" h="10.0" x="18782.492" y="2169.0"/> </glyph> <glyph class="state variable" id="_3b2a4835-9102-41f5-864b-2e90e3188047"> <state value="" variable="T309"/> <bbox w="30.0" h="10.0" x="18822.031" y="2169.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s431_shh1_shh1_sa243" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 2 HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Glioma-associated oncogene family zinc finger PMID:18497536 PMID:17845852 PMID:11001584 References_end</body> </html> </notes> <label text="GLI2-185*"/> <bbox w="165.0" h="39.0" x="18396.0" y="2181.0"/> <glyph class="state variable" id="_820ea2c3-fc98-4d96-93d8-292ae66862b8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18446.232" y="2176.0"/> </glyph> <glyph class="state variable" id="_8103e659-5083-412c-b3dc-400df0b35230"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18487.729" y="2176.0"/> </glyph> <glyph class="state variable" id="_914a2140-6ae9-4dc3-b9dc-c7a70fd94753"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18494.355" y="2215.0"/> </glyph> <glyph class="state variable" id="_ea97fb23-b93c-451b-bdd6-5879046cf66e"> <state value="P" variable="S801"/> <bbox w="35.0" h="10.0" x="18446.906" y="2176.0"/> </glyph> <glyph class="state variable" id="_19eca086-a3ee-4e40-bafc-b06e18c8e661"> <state value="" variable="K757"/> <bbox w="30.0" h="10.0" x="18381.0" y="2188.1248"/> </glyph> <glyph class="state variable" id="_89466496-f44b-4659-8f66-e1476bd8071c"> <state value="" variable="S956"/> <bbox w="30.0" h="10.0" x="18381.0" y="2214.7292"/> </glyph> <glyph class="state variable" id="_7554bc9b-7f3d-480e-8870-015dc3f1b6df"> <state value="" variable="S817"/> <bbox w="30.0" h="10.0" x="18544.725" y="2215.0"/> </glyph> <glyph class="state variable" id="_eb4b8b5d-5c0d-4994-a315-f9e9801093a4"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="18468.5" y="2176.0"/> </glyph> <glyph class="state variable" id="_fa25d7bf-022a-4390-b832-d9d670826837"> <state value="" variable="S847"/> <bbox w="30.0" h="10.0" x="18432.22" y="2215.0"/> </glyph> <glyph class="state variable" id="_62bd360d-c81c-46e4-8822-4a7a9ed10ba5"> <state value="P" variable="S385"/> <bbox w="35.0" h="10.0" x="18378.5" y="2195.469"/> </glyph> <glyph class="state variable" id="_f5f163fc-7351-4e23-8a0e-25c59d4bb11b"> <state value="" variable="S789"/> <bbox w="30.0" h="10.0" x="18381.0" y="2187.6755"/> </glyph> <glyph class="state variable" id="_fbc6327d-251c-447b-bf2c-6b540cb0581d"> <state value="P" variable="S1011"/> <bbox w="40.0" h="10.0" x="18376.0" y="2202.363"/> </glyph> <glyph class="state variable" id="_2790c6c4-917a-4e10-a39f-1180c3606789"> <state value="" variable="S805"/> <bbox w="30.0" h="10.0" x="18484.635" y="2176.0"/> </glyph> <glyph class="state variable" id="_6ffd9852-9a06-4c4a-84c1-a641171a137f"> <state value="P" variable="S820"/> <bbox w="35.0" h="10.0" x="18506.889" y="2215.0"/> </glyph> <glyph class="state variable" id="_70c500f4-8b0f-4554-86f6-a5b4f104060a"> <state value="P" variable="S813"/> <bbox w="35.0" h="10.0" x="18543.5" y="2195.562"/> </glyph> <glyph class="state variable" id="_dbf750ef-a19a-4146-b12e-a3dfb9faaafc"> <state value="P" variable="S850"/> <bbox w="35.0" h="10.0" x="18378.5" y="2213.9749"/> </glyph> <glyph class="state variable" id="_14b937d2-6967-4f83-a8fd-8f5649782017"> <state value="P" variable="S844"/> <bbox w="35.0" h="10.0" x="18455.846" y="2215.0"/> </glyph> <glyph class="state variable" id="_c63afe5a-f2ad-4bfc-9cf1-616d7fee3800"> <state value="P" variable="S792"/> <bbox w="35.0" h="10.0" x="18379.516" y="2176.0"/> </glyph> <glyph class="state variable" id="_5a7a1dbd-a807-4225-b5c5-e096bab6b091"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="18491.855" y="2215.0"/> </glyph> <glyph class="state variable" id="_4fac31e2-1dbd-4b81-bca5-7e1ccee6b6eb"> <state value="P" variable="S808"/> <bbox w="35.0" h="10.0" x="18542.744" y="2176.0"/> </glyph> <glyph class="state variable" id="_454eafe3-8db1-4a0c-a1f6-42feb4dad12e"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="18429.74" y="2176.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s432_shh1_shh1_sa246" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re75:(MAP:survival) PMID:18455992 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A HUGO:DYRK1A HGNC:3091 ENTREZ:1859 UNIPROT:Q13627 GENECARDS:DYRK1A REACTOME:54046 KEGG:1859 ATLASONC:DYRK1AID43234ch21q22 WIKI:DYRK1A 1859 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B HUGO:DYRK1B HGNC:3092 ENTREZ:9149 UNIPROT:Q9Y463 GENECARDS:DYRK1B KEGG:9149 ATLASONC:DYRK1BID43235ch19q13 WIKI:DYRK1B 9149 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 HUGO:DYRK2 HGNC:3093 ENTREZ:8445 UNIPROT:Q92630 GENECARDS:DYRK2 ATLASONC:GC_DYRK2 WIKI:DYRK2 8445 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 HUGO:DYRK3 HGNC:3094 ENTREZ:8444 UNIPROT:O43781 GENECARDS:DYRK3 KEGG:8444 ATLASONC:GC_DYRK3 WIKI:DYRK3 8444 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 HUGO:DYRK4 HGNC:3095 ENTREZ:8798 UNIPROT:Q9NR20 GENECARDS:DYRK4 ATLASONC:GC_DYRK4 WIKI:DYRK4 8798 DYRK, DYRK1, MNBH Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:9932450 PMID:19685005 References_end Identifiers_begin: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A HUGO:DYRK1A HGNC:3091 ENTREZ:1859 UNIPROT:Q13627 GENECARDS:DYRK1A REACTOME:54046 KEGG:1859 ATLASONC:DYRK1AID43234ch21q22 WIKI:DYRK1A 1859 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B HUGO:DYRK1B HGNC:3092 ENTREZ:9149 UNIPROT:Q9Y463 GENECARDS:DYRK1B KEGG:9149 ATLASONC:DYRK1BID43235ch19q13 WIKI:DYRK1B 9149 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 HUGO:DYRK2 HGNC:3093 ENTREZ:8445 UNIPROT:Q92630 GENECARDS:DYRK2 ATLASONC:GC_DYRK2 WIKI:DYRK2 8445 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 HUGO:DYRK3 HGNC:3094 ENTREZ:8444 UNIPROT:O43781 GENECARDS:DYRK3 KEGG:8444 ATLASONC:GC_DYRK3 WIKI:DYRK3 8444 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 HUGO:DYRK4 HGNC:3095 ENTREZ:8798 UNIPROT:Q9NR20 GENECARDS:DYRK4 ATLASONC:GC_DYRK4 WIKI:DYRK4 8798 DYRK, DYRK1, MNBH Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:9932450 PMID:19685005 References_end</body> </html> </notes> <label text="DYRK*"/> <bbox w="80.0" h="40.0" x="18978.5" y="2174.0"/> <glyph class="state variable" id="_ee7e59a1-d4dc-49bf-adda-e5be42e0b90c"> <state value="P" variable="T308"/> <bbox w="35.0" h="10.0" x="18961.492" y="2169.0"/> </glyph> <glyph class="state variable" id="_af2c7a69-2331-4177-a838-6b329dab2fd3"> <state value="P" variable="T309"/> <bbox w="35.0" h="10.0" x="19001.031" y="2169.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s433_shh1_shh1_sa247" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re75:(MAP:survival) PMID:18455992 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Mitogen-activated protein kinase kinase kinase 10 HUGO:MAP3K10 HGNC:6849 ENTREZ:4294 UNIPROT:Q02779 GENECARDS:MAP3K10 KEGG:4294 ATLASONC:GC_MAP3K10 WIKI:MAP3K10 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11274345 References_end</body> </html> </notes> <label text="MAP3K10"/> <bbox w="80.0" h="40.0" x="18888.0" y="2287.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s300_shh1_shh1_sa157" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: arrestin beta 2 ARR2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> Identifiers_begin: Arrestin beta 1 HUGO:ARRB1 HGNC:711 ENTREZ:408 UNIPROT:P49407 GENECARDS:ARRB1 REACTOME:404181 KEGG:408 ATLASONC:GC_ARRB1 WIKI:ARRB1 Arrestin beta 2 HUGO:ARRB2 HGNC:712 ENTREZ:409 UNIPROT:P32121 GENECARDS:ARRB2 REACTOME:50317 KEGG:409 ATLASONC:GC_ARRB2 WIKI:ARRB2 ARR2 arrestin 3", BARR2, DKFZp686L0365 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19853559 PMID:18497258 PMID:15618519 Beta-ARRESTIN 2 bind to both GRK-phosphorylated receptor and to the component kinases of the ERK cascade resulting in assembly of an ERK activation complex that is targeted into endosomal vesicles. MEK1/2 and ERK1/2 were reported to be localised in early endosomes to which they are recruited mainly by beta-ARRESTIN. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <label text="β-Arrestin2*"/> <bbox w="80.0" h="40.0" x="19373.125" y="489.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s357_shh1_shh1_sa168" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re40(MAP:survival): PMID:20956384 PMID:20643644 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <bbox w="80.0" h="40.0" x="19860.0" y="290.0"/> <glyph class="state variable" id="_c8517beb-727c-4518-a508-d349ad21136b"> <state value="" variable="K257"/> <bbox w="30.0" h="10.0" x="19845.492" y="285.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s316_shh1_shh1_sa169" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re40(MAP:survival): PMID:20956384 PMID:20643644 s_shh1_re45(MAP:survival): PMID:19878745 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 2 HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Glioma-associated oncogene family zinc finger PMID:18497536 PMID:17845852 PMID:11001584 References_end</body> </html> </notes> <label text="GLI2-185*"/> <bbox w="165.0" h="39.0" x="19992.75" y="346.87875"/> <glyph class="state variable" id="_944a6bb1-a1af-4008-b897-85683e57e96e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20042.982" y="341.87875"/> </glyph> <glyph class="state variable" id="_33408592-ecb5-49a3-9bdf-11dbab086922"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20084.479" y="341.87875"/> </glyph> <glyph class="state variable" id="_e05f5c62-c2d0-4b11-b33a-289335d80b2b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20091.105" y="380.87875"/> </glyph> <glyph class="state variable" id="_f451e20e-dbab-4f75-a259-c12debaa2490"> <state value="" variable="S801"/> <bbox w="30.0" h="10.0" x="20046.156" y="341.87875"/> </glyph> <glyph class="state variable" id="_cb546f82-b239-4485-a44a-79792b00bcee"> <state value="" variable="K757"/> <bbox w="30.0" h="10.0" x="19977.75" y="354.00342"/> </glyph> <glyph class="state variable" id="_ed51d98e-15b6-4359-94b5-683423c1c69b"> <state value="" variable="S956"/> <bbox w="30.0" h="10.0" x="19977.75" y="380.608"/> </glyph> <glyph class="state variable" id="_6f2b3b3b-3154-426c-9b2a-e047493d7ac5"> <state value="" variable="S817"/> <bbox w="30.0" h="10.0" x="20141.475" y="380.87875"/> </glyph> <glyph class="state variable" id="_2b1bb09f-b69c-4577-a37e-58c46923713e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20070.25" y="341.87875"/> </glyph> <glyph class="state variable" id="_6d4e6cdd-92f5-4ed6-8478-785be6c9c815"> <state value="" variable="S847"/> <bbox w="30.0" h="10.0" x="20028.97" y="380.87875"/> </glyph> <glyph class="state variable" id="_e9a985e2-4ea9-4b63-83b3-43199ec47d5b"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="19977.75" y="361.3477"/> </glyph> <glyph class="state variable" id="_e322bf0a-76fc-48c1-83b5-41184c9ef3f6"> <state value="" variable="S789"/> <bbox w="30.0" h="10.0" x="19977.75" y="353.55417"/> </glyph> <glyph class="state variable" id="_58fc2ea0-7bda-4374-8109-3a2e5124fa5a"> <state value="" variable="S1011"/> <bbox w="35.0" h="10.0" x="19975.25" y="368.2417"/> </glyph> <glyph class="state variable" id="_d60e55f7-c9d8-4c6a-aec0-4729a8f4ddf1"> <state value="" variable="S805"/> <bbox w="30.0" h="10.0" x="20081.385" y="341.87875"/> </glyph> <glyph class="state variable" id="_ea342745-3491-4c34-8c9c-b781e38a2812"> <state value="" variable="S820"/> <bbox w="30.0" h="10.0" x="20106.139" y="380.87875"/> </glyph> <glyph class="state variable" id="_f0210d29-b0b7-49d7-8ee1-d5a62f0dc9a1"> <state value="" variable="S813"/> <bbox w="30.0" h="10.0" x="20142.75" y="361.44086"/> </glyph> <glyph class="state variable" id="_a5d60998-355f-418e-bbfd-586e4a8d882f"> <state value="" variable="S850"/> <bbox w="30.0" h="10.0" x="19977.75" y="379.85355"/> </glyph> <glyph class="state variable" id="_967f4ecd-39f7-439a-a17d-47609a460f92"> <state value="" variable="S844"/> <bbox w="30.0" h="10.0" x="20055.096" y="380.87875"/> </glyph> <glyph class="state variable" id="_133aed35-14f5-40ab-9145-a468330295d3"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="19978.766" y="341.87875"/> </glyph> <glyph class="state variable" id="_dcfa1d9a-fa73-4738-b57b-1f81c3e88fc9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20091.105" y="380.87875"/> </glyph> <glyph class="state variable" id="_d5d4bde6-10a4-4c8c-9315-bde8e6bbff48"> <state value="" variable="S808"/> <bbox w="30.0" h="10.0" x="20141.994" y="341.87875"/> </glyph> <glyph class="state variable" id="_5a15ad69-e024-491d-a670-79f80bebff1a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20031.49" y="341.87875"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s318_shh1_shh1_sa171" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re77(MAP:survival): PMID:20711444 PTM=sumoylation N/A in CellDesigner. Sumoylation not detected on endogenous Gli proteins References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 3 HUGO:GLI3 HGNC:4319 ENTREZ:2737 UNIPROT:P10071 GENECARDS:GLI3 KEGG:2737 ATLASONC:GC_GLI3 WIKI:GLI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI3-190*"/> <clone/> <bbox w="165.0" h="41.0" x="19992.75" y="448.0"/> <glyph class="state variable" id="_eca2479b-6e1a-44eb-86a0-10961fc5ede2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20019.76" y="443.0"/> </glyph> <glyph class="state variable" id="_1160f4fe-7654-4c1d-8499-c4862654bfc8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20039.271" y="443.0"/> </glyph> <glyph class="state variable" id="_2b585a0a-385c-494b-8228-fa10f9ccff4a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20052.734" y="443.0"/> </glyph> <glyph class="state variable" id="_d70a7f8c-4b1b-4333-aaf3-2f2ad2cc85fe"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20091.105" y="484.0"/> </glyph> <glyph class="state variable" id="_45217f62-c66a-4c13-8a6d-65445e4c8ee1"> <state value="" variable="S860"/> <bbox w="30.0" h="10.0" x="20077.902" y="443.0"/> </glyph> <glyph class="state variable" id="_5ccabc0e-5a9c-42bb-8007-bd9911fbf2b5"> <state value="" variable="S907"/> <bbox w="30.0" h="10.0" x="20025.137" y="484.0"/> </glyph> <glyph class="state variable" id="_fd70d932-6531-4aa7-a85a-b1b140786de0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20019.76" y="443.0"/> </glyph> <glyph class="state variable" id="_ece2069e-88ae-4192-98c6-d814d4f21bea"> <state value="" variable="S873"/> <bbox w="30.0" h="10.0" x="20142.75" y="463.5653"/> </glyph> <glyph class="state variable" id="_636ea141-f940-4295-ada8-1ebbaec7823b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20039.271" y="443.0"/> </glyph> <glyph class="state variable" id="_788daec5-97b9-4159-9b76-d4acc6016be9"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="19978.766" y="443.0"/> </glyph> <glyph class="state variable" id="_b1a72769-7035-40c6-bb7a-cb00796ea88e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20052.734" y="443.0"/> </glyph> <glyph class="state variable" id="_31c36013-d32f-4265-971e-4d3fc68aeb22"> <state value="" variable="S868"/> <bbox w="30.0" h="10.0" x="20135.701" y="443.0"/> </glyph> <glyph class="state variable" id="_f0de83bb-aef6-4fce-a94d-82673f3889f8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20091.105" y="484.0"/> </glyph> <glyph class="state variable" id="_ed032d51-3cd4-4793-989d-500e069af169"> <state value="" variable="S877"/> <bbox w="30.0" h="10.0" x="20141.475" y="484.0"/> </glyph> <glyph class="state variable" id="_73c2a102-4d89-4715-b80e-437091befa23"> <state value="" variable="S880"/> <bbox w="30.0" h="10.0" x="20098.85" y="484.0"/> </glyph> <glyph class="state variable" id="_aa574c62-eb20-4e17-b444-b8201a377095"> <state value="" variable="S903"/> <bbox w="30.0" h="10.0" x="20061.703" y="484.0"/> </glyph> <glyph class="state variable" id="_28d9d848-5d64-43c1-b4d2-6e06130bdf88"> <state value="" variable="S910"/> <bbox w="30.0" h="10.0" x="19978.244" y="484.0"/> </glyph> <glyph class="state variable" id="_2e5c51c4-951a-499f-a9e3-52f077e58130"> <state value="" variable="S852"/> <bbox w="30.0" h="10.0" x="20058.666" y="443.0"/> </glyph> <glyph class="state variable" id="_5c4f62f3-62ce-4792-855a-aeeef38831fd"> <state value="" variable="S1006"/> <bbox w="35.0" h="10.0" x="19975.25" y="458.0116"/> </glyph> <glyph class="state variable" id="_1e148a35-225f-4a15-ba80-ad6db6e97156"> <state value="" variable="S865"/> <bbox w="30.0" h="10.0" x="20095.207" y="443.0"/> </glyph> <glyph class="state variable" id="_77e60a09-4c2a-4d5b-a2f7-32bb5a9de5c0"> <state value="" variable="S980"/> <bbox w="30.0" h="10.0" x="19977.75" y="465.7311"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s318_shh1_shh1_sa189" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re77(MAP:survival): PMID:20711444 PTM=sumoylation N/A in CellDesigner. Sumoylation not detected on endogenous Gli proteins References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 3 HUGO:GLI3 HGNC:4319 ENTREZ:2737 UNIPROT:P10071 GENECARDS:GLI3 KEGG:2737 ATLASONC:GC_GLI3 WIKI:GLI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI3-190*"/> <clone/> <bbox w="165.0" h="41.0" x="19869.75" y="795.668"/> <glyph class="state variable" id="_95a3773c-1e05-416f-98c1-ba8478ee28e7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19896.76" y="790.668"/> </glyph> <glyph class="state variable" id="_7b76b55d-6eac-4e20-b690-7e5faa4f174d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19916.271" y="790.668"/> </glyph> <glyph class="state variable" id="_861afea2-bedc-43f6-b687-f5baa4d36661"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19929.734" y="790.668"/> </glyph> <glyph class="state variable" id="_23169a26-f3da-4d76-b2fb-1d787940da69"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19968.105" y="831.668"/> </glyph> <glyph class="state variable" id="_e1df47ba-392d-4295-8b64-4ac87a020eb0"> <state value="" variable="S860"/> <bbox w="30.0" h="10.0" x="19954.902" y="790.668"/> </glyph> <glyph class="state variable" id="_02dca212-51f4-4b3a-bde4-d021c068f2cd"> <state value="" variable="S907"/> <bbox w="30.0" h="10.0" x="19902.137" y="831.668"/> </glyph> <glyph class="state variable" id="_e7a81b9b-0136-4408-850d-0d91351a4795"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19896.76" y="790.668"/> </glyph> <glyph class="state variable" id="_bdde403a-95be-41f1-bd91-7b18e719e37d"> <state value="" variable="S873"/> <bbox w="30.0" h="10.0" x="20019.75" y="811.23334"/> </glyph> <glyph class="state variable" id="_bac45423-ebae-4cf0-ae69-fb9accd5cd1e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19916.271" y="790.668"/> </glyph> <glyph class="state variable" id="_4150d686-2071-4c29-ac5a-e2fc8a28539b"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="19855.766" y="790.668"/> </glyph> <glyph class="state variable" id="_4386d476-b73f-4dd5-92a3-707a63aaaf27"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19929.734" y="790.668"/> </glyph> <glyph class="state variable" id="_3c80c1de-08ea-482a-90d1-4a213e5913f4"> <state value="" variable="S868"/> <bbox w="30.0" h="10.0" x="20012.701" y="790.668"/> </glyph> <glyph class="state variable" id="_f83c7ff3-7f48-41d1-8588-7e849039013e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19968.105" y="831.668"/> </glyph> <glyph class="state variable" id="_d40c8451-aed0-467e-ac80-17a06493dda5"> <state value="" variable="S877"/> <bbox w="30.0" h="10.0" x="20018.475" y="831.668"/> </glyph> <glyph class="state variable" id="_f4739b89-ed70-47e5-b14a-8fbbcf0ec3c7"> <state value="" variable="S880"/> <bbox w="30.0" h="10.0" x="19975.85" y="831.668"/> </glyph> <glyph class="state variable" id="_b97f50db-f037-429e-894d-b690e5c2c04b"> <state value="" variable="S903"/> <bbox w="30.0" h="10.0" x="19938.703" y="831.668"/> </glyph> <glyph class="state variable" id="_f2d36493-78ee-4f42-86d4-792b0792969d"> <state value="" variable="S910"/> <bbox w="30.0" h="10.0" x="19855.244" y="831.668"/> </glyph> <glyph class="state variable" id="_6af444be-845a-4bed-bfb0-6f0c3907e68e"> <state value="" variable="S852"/> <bbox w="30.0" h="10.0" x="19935.666" y="790.668"/> </glyph> <glyph class="state variable" id="_138d988a-a7da-4a2d-b702-f9f2b2934291"> <state value="" variable="S1006"/> <bbox w="35.0" h="10.0" x="19852.25" y="805.6796"/> </glyph> <glyph class="state variable" id="_a8cdf395-fc59-43eb-8e2f-20964bcc4c4e"> <state value="" variable="S865"/> <bbox w="30.0" h="10.0" x="19972.207" y="790.668"/> </glyph> <glyph class="state variable" id="_41410858-e86d-4c47-ae13-30fca4e0703f"> <state value="" variable="S980"/> <bbox w="30.0" h="10.0" x="19854.75" y="813.3991"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s326_shh1_shh1_sa179" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re40(MAP:survival): PMID:20956384 PMID:20643644 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Kinesin family member 7 HUGO:KIF7 HGNC:30497 ENTREZ:374654 UNIPROT:Q2M1P5 GENECARDS:KIF7 KEGG:374654 WIKI:KIF7 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19666503 PMID:19906571 PMID:19592253 PMID:19549984 References_end</body> </html> </notes> <label text="KIF7"/> <bbox w="80.0" h="40.0" x="19892.0" y="503.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s332_shh1_shh1_sa185" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re40(MAP:survival): PMID:20956384 PMID:20643644 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Unc-51-like kinase 3 HUGO:ULK3 HGNC:19703 ENTREZ:25989 UNIPROT:Q6PHR2 GENECARDS:ULK3 ATLASONC:GC_ULK3 WIKI:ULK3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Unc-51-like kinase PMID:20643644 PMID:19878745 References_end</body> </html> </notes> <label text="ULK3"/> <bbox w="80.0" h="40.0" x="19281.5" y="795.668"/> <glyph class="state variable" id="_ab7558c3-b9bd-4f59-a311-f73d61f5bb83"> <state value="" variable="S384"/> <bbox w="30.0" h="10.0" x="19345.88" y="830.668"/> </glyph> <glyph class="state variable" id="_6d4b8bb6-6bfa-42f9-b3b2-63f8d6fe8243"> <state value="" variable="S464"/> <bbox w="30.0" h="10.0" x="19266.5" y="830.3903"/> </glyph> <glyph class="state variable" id="_481787c6-0ec9-4e95-9e28-ffea2b73b36e"> <state value="" variable="S300"/> <bbox w="30.0" h="10.0" x="19266.992" y="790.668"/> </glyph> <glyph class="state variable" id="_7642fe18-d78f-4429-954a-78eeef6e4163"> <state value="" variable="S350"/> <bbox w="30.0" h="10.0" x="19346.5" y="790.8828"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s362_shh1_shh1_sa193" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re52:(MAP:survival) PMID:20016067 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Protein kinase cAMP-depenedent catalytic alpha HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA Protein kinase cAMP-depenedent catalytic beta HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB Protein kinase cAMP-depenedent catalytic gamma HUGOPRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20027184 References_end</body> </html> </notes> <label text="PKA*"/> <clone/> <bbox w="80.0" h="40.0" x="19216.5" y="718.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s362_shh1_shh1_sa195" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re52:(MAP:survival) PMID:20016067 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Protein kinase cAMP-depenedent catalytic alpha HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA Protein kinase cAMP-depenedent catalytic beta HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB Protein kinase cAMP-depenedent catalytic gamma HUGOPRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20027184 References_end</body> </html> </notes> <label text="PKA*"/> <clone/> <bbox w="80.0" h="40.0" x="19365.5" y="949.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s336_shh1_shh1_sa187" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19878745 Ulk3 phosphorylates Gli2 but not know on which residue s_shh1_re45(MAP:survival): PMID:20643644 s_shh1_re76(MAP:survival): PMID:20711444 PTM=sumoylation N/A in CellDesigner. Sumoylation not detected on endogenous Gli proteins. PKA antagonise sumoylation due to the consequence of PKA phosphorylation on Gli proteins it is not a direct effect of PKA. Exact References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 2 HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Glioma-associated oncogene family zinc finger PMID:18497536 PMID:17845852 PMID:11001584 References_end</body> </html> </notes> <label text="GLI2-185*"/> <bbox w="165.0" h="39.0" x="19605.166" y="795.668"/> <glyph class="state variable" id="_f9b53e38-7878-491c-9846-30964fe929bc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19655.398" y="790.668"/> </glyph> <glyph class="state variable" id="_7972122d-a0c9-4466-ab74-c4e32d02e712"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19696.895" y="790.668"/> </glyph> <glyph class="state variable" id="_fa82b947-2b28-4474-b906-8b103e8f30c3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19703.521" y="829.668"/> </glyph> <glyph class="state variable" id="_5305110c-555b-47cb-a170-613c10dc19a2"> <state value="" variable="S801"/> <bbox w="30.0" h="10.0" x="19658.572" y="790.668"/> </glyph> <glyph class="state variable" id="_b5c23c29-b540-4880-b4d8-c8bcbbc38729"> <state value="" variable="K757"/> <bbox w="30.0" h="10.0" x="19590.166" y="802.7927"/> </glyph> <glyph class="state variable" id="_c8396865-a343-4179-997b-d4845a3bb9c8"> <state value="" variable="S956"/> <bbox w="30.0" h="10.0" x="19590.166" y="829.3973"/> </glyph> <glyph class="state variable" id="_62548235-4fce-4278-bda5-c4a4ccb0666a"> <state value="" variable="S817"/> <bbox w="30.0" h="10.0" x="19753.89" y="829.668"/> </glyph> <glyph class="state variable" id="_9e1c20f9-4aba-4a87-993a-30c5fa1fa0ee"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="19680.166" y="790.668"/> </glyph> <glyph class="state variable" id="_746a9d14-d700-4f41-b061-f24d734d439b"> <state value="" variable="S847"/> <bbox w="30.0" h="10.0" x="19641.387" y="829.668"/> </glyph> <glyph class="state variable" id="_c435dc71-9175-4afd-9fb8-a071c595967e"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="19590.166" y="810.13696"/> </glyph> <glyph class="state variable" id="_8abcded3-b254-4ba5-a281-029614fc0b32"> <state value="" variable="S789"/> <bbox w="30.0" h="10.0" x="19590.166" y="802.34344"/> </glyph> <glyph class="state variable" id="_5e878520-0f3c-4512-b04c-f2ab3b420d98"> <state value="" variable="S1011"/> <bbox w="35.0" h="10.0" x="19587.666" y="817.031"/> </glyph> <glyph class="state variable" id="_956c41f0-f1b0-49bd-9438-ac209cfdc992"> <state value="" variable="S805"/> <bbox w="30.0" h="10.0" x="19693.8" y="790.668"/> </glyph> <glyph class="state variable" id="_b74357ac-8f94-4197-9370-bac3e50e1d87"> <state value="" variable="S820"/> <bbox w="30.0" h="10.0" x="19718.555" y="829.668"/> </glyph> <glyph class="state variable" id="_144b2f09-a6f9-45c4-84f4-a3fc6a1d1b11"> <state value="" variable="S813"/> <bbox w="30.0" h="10.0" x="19755.166" y="810.23016"/> </glyph> <glyph class="state variable" id="_7ada2d75-de5d-403d-92fa-bf7758ba72ba"> <state value="" variable="S850"/> <bbox w="30.0" h="10.0" x="19590.166" y="828.6428"/> </glyph> <glyph class="state variable" id="_c71fc3a6-3d7f-47c5-ae73-62ee9d4d74be"> <state value="" variable="S844"/> <bbox w="30.0" h="10.0" x="19667.512" y="829.668"/> </glyph> <glyph class="state variable" id="_74eae5a2-fd80-4e2e-9cd4-26a21def7c2c"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="19591.182" y="790.668"/> </glyph> <glyph class="state variable" id="_a55e1c63-040b-470e-841d-e7b8b286c4bc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19703.521" y="829.668"/> </glyph> <glyph class="state variable" id="_d03b6836-d6a5-455b-acba-b84d1d8f7824"> <state value="" variable="S808"/> <bbox w="30.0" h="10.0" x="19754.41" y="790.668"/> </glyph> <glyph class="state variable" id="_a26699c6-845d-4316-adae-c1ab2fd63b8d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19643.906" y="790.668"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s448_shh1_shh1_sa250" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re76(MAP:survival): PMID:20711444 PTM=sumoylation N/A in CellDesigner. Sumoylation not detected on endogenous Gli proteins. PKA antagonise sumoylation due to the consequence of PKA phosphorylation on Gli proteins it is not a direct effect of PKA. Exact References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Ubiquitin-conjugating enzyme E2I HUGO:UBE21 GENECARDS:UBE21 WIKI:UBE21 HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I "ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9)", "ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)" HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I HUGO:MSH6 HGNC:7329 ENTREZ:2956 UNIPROT:P52701 GENECARDS:MSH6 KEGG:2956 ATLASONC:MSH6ID344ch2p16 WIKI:MSH6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20711444 References_end Identifiers_begin: Ubiquitin-conjugating enzyme E2I HUGO:UBE21 GENECARDS:UBE21 WIKI:UBE21 HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I "ubiquitin-conjugating enzyme E2I (homologous to yeast UBC9)", "ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)" HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I HUGO:MSH6 HGNC:7329 ENTREZ:2956 UNIPROT:P52701 GENECARDS:MSH6 KEGG:2956 ATLASONC:MSH6ID344ch2p16 WIKI:MSH6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20711444 References_end</body> </html> </notes> <label text="UBC9*"/> <bbox w="80.0" h="40.0" x="20095.0" y="864.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s449_shh1_shh1_sa251" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re76(MAP:survival): PMID:20711444 PTM=sumoylation N/A in CellDesigner. Sumoylation not detected on endogenous Gli proteins. PKA antagonise sumoylation due to the consequence of PKA phosphorylation on Gli proteins it is not a direct effect of PKA. Exact References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Protein inhibitor of activated STAT 1 HUGO:PIAS1 HGNC:2752 ENTREZ:8554 UNIPROT:O75925 GENECARDS:PIAS1 REACTOME:61690 KEGG:8554 ATLASONC:GC_PIAS1 WIKI:PIAS1 DDXBP1 "DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20711444 References_end Identifiers_begin: Protein inhibitor of activated STAT 1 HUGO:PIAS1 HGNC:2752 ENTREZ:8554 UNIPROT:O75925 GENECARDS:PIAS1 REACTOME:61690 KEGG:8554 ATLASONC:GC_PIAS1 WIKI:PIAS1 DDXBP1 "DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20711444 References_end Identifiers_begin: Protein inhibitor of activated STAT 1 HUGO:PIAS1 HGNC:2752 ENTREZ:8554 UNIPROT:O75925 GENECARDS:PIAS1 REACTOME:61690 KEGG:8554 ATLASONC:GC_PIAS1 WIKI:PIAS1 DDXBP1 "DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20711444 References_end</body> </html> </notes> <label text="PIAS1"/> <bbox w="80.0" h="40.0" x="20095.0" y="935.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s450_shh1_shh1_sa252" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re76(MAP:survival): PMID:20711444 PTM=sumoylation N/A in CellDesigner. Sumoylation not detected on endogenous Gli proteins. PKA antagonise sumoylation due to the consequence of PKA phosphorylation on Gli proteins it is not a direct effect of PKA. Exact s_shh1_re53:(MAP:survival) PMID:19996169 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 2 HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Glioma-associated oncogene family zinc finger PMID:18497536 PMID:17845852 PMID:11001584 References_end</body> </html> </notes> <label text="GLI2-185*"/> <bbox w="165.0" h="39.0" x="19605.166" y="908.0"/> <glyph class="state variable" id="_2f0ce75d-bc09-4846-86af-720fe2182fce"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19655.398" y="903.0"/> </glyph> <glyph class="state variable" id="_01bcff5a-0f81-4ac7-9ea7-4addebdc7a64"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19696.895" y="903.0"/> </glyph> <glyph class="state variable" id="_71e76d27-06b9-49d8-98f2-c3a6e0d5d893"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19703.521" y="942.0"/> </glyph> <glyph class="state variable" id="_68561d6b-d127-4da2-aca5-e4536e9353ce"> <state value="" variable="S801"/> <bbox w="30.0" h="10.0" x="19658.572" y="903.0"/> </glyph> <glyph class="state variable" id="_5e5b82d3-5b21-49d6-b266-6e309ec14877"> <state value="" variable="K757"/> <bbox w="30.0" h="10.0" x="19590.166" y="915.1247"/> </glyph> <glyph class="state variable" id="_0189abfa-78c0-46ee-aa27-5f4721f69de0"> <state value="" variable="S956"/> <bbox w="30.0" h="10.0" x="19590.166" y="941.72925"/> </glyph> <glyph class="state variable" id="_57272b82-1a66-4505-8b19-9e3ced5d533b"> <state value="" variable="S817"/> <bbox w="30.0" h="10.0" x="19753.89" y="942.0"/> </glyph> <glyph class="state variable" id="_51fb3b69-d2e4-4029-aa35-898cf9889263"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="19680.166" y="903.0"/> </glyph> <glyph class="state variable" id="_378f1c5a-460d-489e-9f0b-da4000fe4d24"> <state value="" variable="S847"/> <bbox w="30.0" h="10.0" x="19641.387" y="942.0"/> </glyph> <glyph class="state variable" id="_96a51ed3-14c8-4c69-917d-2adaccae29fd"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="19590.166" y="922.46893"/> </glyph> <glyph class="state variable" id="_fe51e57c-3061-47d2-a1af-5288de52143a"> <state value="" variable="S789"/> <bbox w="30.0" h="10.0" x="19590.166" y="914.6754"/> </glyph> <glyph class="state variable" id="_ea79c5ec-14d8-4fea-8cd5-c21ab5192cc9"> <state value="" variable="S1011"/> <bbox w="35.0" h="10.0" x="19587.666" y="929.363"/> </glyph> <glyph class="state variable" id="_e033cb14-65db-47ff-b8d0-b06e96d98c35"> <state value="?" variable="S805"/> <bbox w="35.0" h="10.0" x="19691.3" y="903.0"/> </glyph> <glyph class="state variable" id="_34bbbb67-4224-4a0a-aec9-a3c262f63009"> <state value="" variable="S820"/> <bbox w="30.0" h="10.0" x="19718.555" y="942.0"/> </glyph> <glyph class="state variable" id="_8e4aa1ba-6375-45aa-b48d-1de1b4f4001b"> <state value="" variable="S813"/> <bbox w="30.0" h="10.0" x="19755.166" y="922.56213"/> </glyph> <glyph class="state variable" id="_c102e65a-97b1-4854-ba5a-5d9b7ab6438a"> <state value="" variable="S850"/> <bbox w="30.0" h="10.0" x="19590.166" y="940.9748"/> </glyph> <glyph class="state variable" id="_bdbe3e0a-deca-4945-a0ea-1471b3f98c15"> <state value="" variable="S844"/> <bbox w="30.0" h="10.0" x="19667.512" y="942.0"/> </glyph> <glyph class="state variable" id="_4d0ca7d0-b3a1-459f-88e5-a7121acae3ba"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="19591.182" y="903.0"/> </glyph> <glyph class="state variable" id="_9fc1ce1f-c04d-4c89-bd51-2c22a9c46dad"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19703.521" y="942.0"/> </glyph> <glyph class="state variable" id="_e79d886e-6821-418c-8fce-b94e25845cf3"> <state value="" variable="S808"/> <bbox w="30.0" h="10.0" x="19754.41" y="903.0"/> </glyph> <glyph class="state variable" id="_424c0c9e-a31a-44ef-81fb-059e1cbd8e57"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19643.906" y="903.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s451_shh1_shh1_sa253" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20711444 PTM=sumoylation N/A in CellDesigner s_shh1_re77(MAP:survival): Sumoylation not detected on endogenous Gli proteins s_shh1_re48(MAP:survival): PMID:20360384 PMID:19996169 PMID:18559511 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 3 HUGO:GLI3 HGNC:4319 ENTREZ:2737 UNIPROT:P10071 GENECARDS:GLI3 KEGG:2737 ATLASONC:GC_GLI3 WIKI:GLI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI3-190*"/> <bbox w="165.0" h="41.0" x="19869.75" y="908.0"/> <glyph class="state variable" id="_674c0f2f-6c3e-4269-aa8a-067e160aee5d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19896.76" y="903.0"/> </glyph> <glyph class="state variable" id="_5a0f4067-88ae-4755-9b09-e1843dc3daf3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19916.271" y="903.0"/> </glyph> <glyph class="state variable" id="_25b196de-f847-4c81-a281-0a77ed5d9fea"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19929.734" y="903.0"/> </glyph> <glyph class="state variable" id="_cdca62f1-dd91-4786-8aaf-d8e636329d07"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19968.105" y="944.0"/> </glyph> <glyph class="state variable" id="_12fdd622-b8f4-4983-85ea-c92c1aa2676d"> <state value="" variable="S860"/> <bbox w="30.0" h="10.0" x="19954.902" y="903.0"/> </glyph> <glyph class="state variable" id="_e09c3697-e9a3-4d7c-939f-049f6a595429"> <state value="" variable="S907"/> <bbox w="30.0" h="10.0" x="19902.137" y="944.0"/> </glyph> <glyph class="state variable" id="_2b34167c-f209-4f49-a28a-53830bd672a4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19896.76" y="903.0"/> </glyph> <glyph class="state variable" id="_9c786c4c-4525-4851-8e47-68b9ac059bc1"> <state value="" variable="S873"/> <bbox w="30.0" h="10.0" x="20019.75" y="923.5653"/> </glyph> <glyph class="state variable" id="_0a3fc3f2-9976-43a0-82f6-255c0b87a49d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19916.271" y="903.0"/> </glyph> <glyph class="state variable" id="_db25a9dd-f793-4c08-a005-0d16921bafe6"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="19855.766" y="903.0"/> </glyph> <glyph class="state variable" id="_adaabe79-0d61-4ae3-b002-871c2b74c4da"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19929.734" y="903.0"/> </glyph> <glyph class="state variable" id="_989b0937-aa22-4993-a805-b62afbdf5262"> <state value="" variable="S868"/> <bbox w="30.0" h="10.0" x="20012.701" y="903.0"/> </glyph> <glyph class="state variable" id="_76b231ea-689f-4a01-99d8-aab8474caf7b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19968.105" y="944.0"/> </glyph> <glyph class="state variable" id="_b4d9d233-debc-415d-8734-67fe5d53792a"> <state value="" variable="S877"/> <bbox w="30.0" h="10.0" x="20018.475" y="944.0"/> </glyph> <glyph class="state variable" id="_247f9de6-0918-47e2-b6fd-b324868b352e"> <state value="?" variable="S880"/> <bbox w="35.0" h="10.0" x="19973.35" y="944.0"/> </glyph> <glyph class="state variable" id="_672d95fb-cb61-49d5-b6e1-0c988b93b6aa"> <state value="" variable="S903"/> <bbox w="30.0" h="10.0" x="19938.703" y="944.0"/> </glyph> <glyph class="state variable" id="_9f20ded8-500e-47a5-a193-3579b9a7b75f"> <state value="" variable="S910"/> <bbox w="30.0" h="10.0" x="19855.244" y="944.0"/> </glyph> <glyph class="state variable" id="_51275f61-38c6-4342-9ccb-a701c8ec481b"> <state value="" variable="S852"/> <bbox w="30.0" h="10.0" x="19935.666" y="903.0"/> </glyph> <glyph class="state variable" id="_11a66761-17a0-412c-87d7-2a91c7a51cd6"> <state value="" variable="S1006"/> <bbox w="35.0" h="10.0" x="19852.25" y="918.0116"/> </glyph> <glyph class="state variable" id="_b1702209-820b-4758-bf2b-541c28928532"> <state value="" variable="S865"/> <bbox w="30.0" h="10.0" x="19972.207" y="903.0"/> </glyph> <glyph class="state variable" id="_38f653ec-36e8-4721-ba91-adfdd307f07e"> <state value="" variable="S980"/> <bbox w="30.0" h="10.0" x="19854.75" y="925.7311"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s452_shh1_shh1_sa196" compartmentRef="shh1_shh1_c6_shh1_shh1_ca6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re53:(MAP:survival) PMID:19996169 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 2 HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Glioma-associated oncogene family zinc finger PMID:18497536 PMID:17845852 PMID:11001584 References_end</body> </html> </notes> <label text="GLI2-185*"/> <bbox w="165.0" h="45.0" x="19405.125" y="1771.0"/> <glyph class="state variable" id="_4fd64ed1-1303-4d83-9fd4-58bf51295920"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19455.357" y="1766.0"/> </glyph> <glyph class="state variable" id="_4ab56fad-a90d-4f21-ad10-003483326e17"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19496.854" y="1766.0"/> </glyph> <glyph class="state variable" id="_6e77dc6b-2d2b-48b0-9548-19bd32a576ec"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19503.48" y="1811.0"/> </glyph> <glyph class="state variable" id="_6578e304-5559-4483-964e-5480f50f8c94"> <state value="" variable="S801"/> <bbox w="30.0" h="10.0" x="19458.531" y="1766.0"/> </glyph> <glyph class="state variable" id="_37e8b731-4dc7-4650-857d-598673717727"> <state value="" variable="K757"/> <bbox w="30.0" h="10.0" x="19390.125" y="1779.99"/> </glyph> <glyph class="state variable" id="_69093d1b-581c-4e81-ab0f-2384946490ce"> <state value="" variable="S956"/> <bbox w="30.0" h="10.0" x="19390.125" y="1810.6876"/> </glyph> <glyph class="state variable" id="_39147e7a-d562-4ad8-a569-d10f4df7490c"> <state value="" variable="S817"/> <bbox w="30.0" h="10.0" x="19553.85" y="1811.0"/> </glyph> <glyph class="state variable" id="_efab3f5e-45e5-4ec4-8df4-00bcbcd273e0"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="19480.125" y="1766.0"/> </glyph> <glyph class="state variable" id="_0e9b76c4-192a-457e-9073-d9329eb18eb7"> <state value="" variable="S847"/> <bbox w="30.0" h="10.0" x="19441.346" y="1811.0"/> </glyph> <glyph class="state variable" id="_b164adc6-04fc-4a24-9cee-254e4ce0903e"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="19390.125" y="1788.4641"/> </glyph> <glyph class="state variable" id="_cf5ec759-a518-475e-bc2d-39a3f60d63e8"> <state value="" variable="S789"/> <bbox w="30.0" h="10.0" x="19390.125" y="1779.4717"/> </glyph> <glyph class="state variable" id="_d511c79c-c443-4d83-bd90-242de7867ffc"> <state value="" variable="S1011"/> <bbox w="35.0" h="10.0" x="19387.625" y="1796.4188"/> </glyph> <glyph class="state variable" id="_413b3041-2c88-4320-864b-3952bcfff2af"> <state value="?" variable="S805"/> <bbox w="35.0" h="10.0" x="19491.26" y="1766.0"/> </glyph> <glyph class="state variable" id="_fe347323-28b9-4283-abef-b3f49fb5b1aa"> <state value="" variable="S820"/> <bbox w="30.0" h="10.0" x="19518.514" y="1811.0"/> </glyph> <glyph class="state variable" id="_1db3d713-38de-4979-8329-0fb7b66aeb88"> <state value="" variable="S813"/> <bbox w="30.0" h="10.0" x="19555.125" y="1788.5717"/> </glyph> <glyph class="state variable" id="_108b408b-a402-40d4-a593-8cf232a2a466"> <state value="" variable="S850"/> <bbox w="30.0" h="10.0" x="19390.125" y="1809.817"/> </glyph> <glyph class="state variable" id="_9c80fba3-c115-46b2-87d9-4c19adebaf4a"> <state value="" variable="S844"/> <bbox w="30.0" h="10.0" x="19467.47" y="1811.0"/> </glyph> <glyph class="state variable" id="_2e4243d9-7970-4b05-af44-a8190c1283af"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="19391.14" y="1766.0"/> </glyph> <glyph class="state variable" id="_e5d7695c-e64d-45f3-bcdf-7984fed6dc71"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19503.48" y="1811.0"/> </glyph> <glyph class="state variable" id="_5e7f40d0-b0bb-4b0e-84e9-af3318b68ea9"> <state value="" variable="S808"/> <bbox w="30.0" h="10.0" x="19554.37" y="1766.0"/> </glyph> <glyph class="state variable" id="_92de5a50-0415-436d-8a05-a1355db878f5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19443.865" y="1766.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s453_shh1_shh1_sa188" compartmentRef="shh1_shh1_c6_shh1_shh1_ca6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re48(MAP:survival): PMID:20360384 PMID:19996169 PMID:18559511 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 3 HUGO:GLI3 HGNC:4319 ENTREZ:2737 UNIPROT:P10071 GENECARDS:GLI3 KEGG:2737 ATLASONC:GC_GLI3 WIKI:GLI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI3-190*"/> <bbox w="165.0" h="45.0" x="19686.75" y="1771.0"/> <glyph class="state variable" id="_e8ad14a5-7298-4956-a8f1-05f32ada97d2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19713.76" y="1766.0"/> </glyph> <glyph class="state variable" id="_9e8d7478-7983-445f-9f9a-265f0a4c3b1c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19733.271" y="1766.0"/> </glyph> <glyph class="state variable" id="_3f9f141b-b2ff-4f04-b4a1-33360a43d2ad"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19746.734" y="1766.0"/> </glyph> <glyph class="state variable" id="_41fb4b41-a51b-4008-8932-b5199dcc4b3d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19785.105" y="1811.0"/> </glyph> <glyph class="state variable" id="_b08b3130-488f-453f-8c04-ff6cf4989773"> <state value="" variable="S860"/> <bbox w="30.0" h="10.0" x="19771.902" y="1766.0"/> </glyph> <glyph class="state variable" id="_3c9f11dc-4043-4249-a57d-f46153032488"> <state value="" variable="S907"/> <bbox w="30.0" h="10.0" x="19719.137" y="1811.0"/> </glyph> <glyph class="state variable" id="_93b93137-4030-48d6-9941-7d772f95dd04"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19713.76" y="1766.0"/> </glyph> <glyph class="state variable" id="_b50cf763-3128-4cd6-9357-0ed40ab4fdfa"> <state value="" variable="S873"/> <bbox w="30.0" h="10.0" x="19836.75" y="1788.5717"/> </glyph> <glyph class="state variable" id="_cb90a7f6-8be6-4638-b058-5cd3fa709e78"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19733.271" y="1766.0"/> </glyph> <glyph class="state variable" id="_317401a0-ab96-49b9-89ec-e1e13acc304f"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="19672.766" y="1766.0"/> </glyph> <glyph class="state variable" id="_4a54bec4-8519-427e-bdd1-d6c1df19d047"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19746.734" y="1766.0"/> </glyph> <glyph class="state variable" id="_8061d18d-d55b-4027-b6e0-86fc8697ec74"> <state value="" variable="S868"/> <bbox w="30.0" h="10.0" x="19829.701" y="1766.0"/> </glyph> <glyph class="state variable" id="_819af649-1fda-4824-8300-c128125c50c6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19785.105" y="1811.0"/> </glyph> <glyph class="state variable" id="_c77674cd-4342-4acd-8d20-a465561ddd1a"> <state value="" variable="S877"/> <bbox w="30.0" h="10.0" x="19835.475" y="1811.0"/> </glyph> <glyph class="state variable" id="_0358e5b7-107e-4e67-b95d-d395823a6697"> <state value="?" variable="S880"/> <bbox w="35.0" h="10.0" x="19790.35" y="1811.0"/> </glyph> <glyph class="state variable" id="_7c520f4f-2c85-4d83-b645-6574fcbeaf96"> <state value="" variable="S903"/> <bbox w="30.0" h="10.0" x="19755.703" y="1811.0"/> </glyph> <glyph class="state variable" id="_96b3fdd4-405a-4ee3-9232-f7d822abbf08"> <state value="" variable="S910"/> <bbox w="30.0" h="10.0" x="19672.244" y="1811.0"/> </glyph> <glyph class="state variable" id="_768f430a-ce24-4351-b617-8559f8a9bd33"> <state value="" variable="S852"/> <bbox w="30.0" h="10.0" x="19752.666" y="1766.0"/> </glyph> <glyph class="state variable" id="_0c4fffc1-e311-4973-ba31-965ba77bf9d3"> <state value="" variable="S1006"/> <bbox w="35.0" h="10.0" x="19669.25" y="1782.4761"/> </glyph> <glyph class="state variable" id="_d0c0b715-b96f-489c-a68e-2226f75f5a14"> <state value="" variable="S865"/> <bbox w="30.0" h="10.0" x="19789.207" y="1766.0"/> </glyph> <glyph class="state variable" id="_6398521e-8674-462e-b971-63cdb5b69ec8"> <state value="" variable="S980"/> <bbox w="30.0" h="10.0" x="19671.75" y="1790.9487"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s454_shh1_shh1_sa254" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re79(MAP:survival): PMID:10050855 PMID:16571352 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Hedgehog interacting protein HUGO:HHIP HGNC:14866 ENTREZ:64399 UNIPROT:Q96QV1 GENECARDS:HHIP KEGG:64399 ATLASONC:GC_HHIP WIKI:HHIP Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16571352 PMID:10050855 References_end</body> </html> </notes> <label text="HHIP1"/> <bbox w="78.0" h="114.0" x="19877.0" y="111.0"/> <glyph class="unit of information" id="_2c98e73e-b9c1-4173-87d4-74bd7f9a5082"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="19893.5" y="106.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s458_shh1_shh1_sa257" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re80:(MAP:survival) PMID:18477453 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Glypican 1 HUGO:GPC1 HGNC:4449 ENTREZ:2817 UNIPROT:P35052 GENECARDS:GPC1 REACTOME:55866 KEGG:2817 ATLASONC:GC_GPC1 WIKI:GPC1 Glypican 2 HUGO:GPC2 HGNC:4450 ENTREZ:221914 UNIPROT:Q8N158 GENECARDS:GPC2 REACTOME:230962 WIKI:GPC2 Glypican 3 HUGO:GPC3 HGNC:4451 ENTREZ:2719 UNIPROT:P51654 GENECARDS:GPC3 REACTOME:55868 KEGG:2719 ATLASONC:GPC3ID156 WIKI:GPC3 Glypican 4 HUGO:GPC4 HGNC:4452 ENTREZ:2239 UNIPROT:O75487 GENECARDS:GPC4 REACTOME:55870 KEGG:2239 ATLASONC:GC_GPC4 WIKI:GPC4 Glypican 5 HUGO:GPC5 HGNC:4453 ENTREZ:2262 UNIPROT:P78333 GENECARDS:GPC5 REACTOME:55872 ATLASONC:GPC5ID45705ch13q31 WIKI:GPC5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21112773 PMID:18477453 Glypican References_end</body> </html> </notes> <label text="GPC3"/> <bbox w="78.0" h="114.0" x="20084.0" y="123.0"/> <glyph class="unit of information" id="_05d1880f-9e9e-467a-92ab-5de592eb4429"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="20100.5" y="118.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s470_shh1_shh1_sa123" compartmentRef="shh1_shh1_c3_shh1_shh1_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re20(MAP:survival): PMID17283082. A domain in the a.a. sequence favors the truncation of the protein References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 3 HUGO:GLI3 HGNC:4319 ENTREZ:2737 UNIPROT:P10071 GENECARDS:GLI3 KEGG:2737 ATLASONC:GC_GLI3 WIKI:GLI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI3-190*"/> <bbox w="165.0" h="41.0" x="18315.074" y="1618.7703"/> <glyph class="state variable" id="_3c27c835-5d44-4431-8743-006b8b5be1b4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18342.084" y="1613.7703"/> </glyph> <glyph class="state variable" id="_2c025025-fe7b-400a-b108-a44aadd139ca"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18361.596" y="1613.7703"/> </glyph> <glyph class="state variable" id="_51a008b7-7f05-4087-bb99-dba52cb4c1ae"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18375.059" y="1613.7703"/> </glyph> <glyph class="state variable" id="_021f2842-de9c-4374-b213-85de8240e28e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18413.43" y="1654.7703"/> </glyph> <glyph class="state variable" id="_c343b75c-2444-4100-8c9d-768c7d98164b"> <state value="P" variable="S860"/> <bbox w="35.0" h="10.0" x="18397.727" y="1613.7703"/> </glyph> <glyph class="state variable" id="_4540a6e0-18c2-4352-b419-886cf5b1f585"> <state value="P" variable="S907"/> <bbox w="35.0" h="10.0" x="18344.96" y="1654.7703"/> </glyph> <glyph class="state variable" id="_7a76f00e-a02b-4f41-b35c-576e4ccbb755"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="18337.084" y="1613.7703"/> </glyph> <glyph class="state variable" id="_fffef249-7dbb-4b02-af74-0d0b3d46f0e7"> <state value="P" variable="S873"/> <bbox w="35.0" h="10.0" x="18462.574" y="1634.3356"/> </glyph> <glyph class="state variable" id="_d46c783f-3a18-4f98-a08a-90716bd07302"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="18356.596" y="1613.7703"/> </glyph> <glyph class="state variable" id="_3b94422f-96d3-4d46-bb27-0f01ddd39dce"> <state value="P" variable="S849"/> <bbox w="35.0" h="10.0" x="18298.59" y="1613.7703"/> </glyph> <glyph class="state variable" id="_199c32e2-9fdb-4444-a10c-1127a19af764"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="18370.059" y="1613.7703"/> </glyph> <glyph class="state variable" id="_e0603e98-31e8-41d0-9d71-401d23e0fc80"> <state value="P" variable="S868"/> <bbox w="35.0" h="10.0" x="18455.525" y="1613.7703"/> </glyph> <glyph class="state variable" id="_6ebb02df-bdfe-4e37-bca8-48da3864f3fa"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="18408.43" y="1654.7703"/> </glyph> <glyph class="state variable" id="_0d119833-fbb4-402f-8959-af9eef2a6343"> <state value="P" variable="S877"/> <bbox w="35.0" h="10.0" x="18461.299" y="1654.7703"/> </glyph> <glyph class="state variable" id="_aa099c0a-17eb-4ed8-a218-b8f64999fbb5"> <state value="P" variable="S880"/> <bbox w="35.0" h="10.0" x="18418.674" y="1654.7703"/> </glyph> <glyph class="state variable" id="_f672da8d-312d-431d-8fd7-a19a3dc28e90"> <state value="P" variable="S903"/> <bbox w="35.0" h="10.0" x="18381.527" y="1654.7703"/> </glyph> <glyph class="state variable" id="_70f340ee-9d72-40d7-a933-3afa40fc0e60"> <state value="P" variable="S910"/> <bbox w="35.0" h="10.0" x="18298.068" y="1654.7703"/> </glyph> <glyph class="state variable" id="_523a3fbf-5cf9-4f41-90d5-4b501b5a7d2a"> <state value="P" variable="S852"/> <bbox w="35.0" h="10.0" x="18378.49" y="1613.7703"/> </glyph> <glyph class="state variable" id="_5236cc92-c1b5-4bd6-be8f-d39d3b688179"> <state value="P" variable="S1006"/> <bbox w="40.0" h="10.0" x="18295.074" y="1628.7819"/> </glyph> <glyph class="state variable" id="_c9610c0f-37d1-44ea-a2d7-d05f43f3670c"> <state value="P" variable="S865"/> <bbox w="35.0" h="10.0" x="18415.031" y="1613.7703"/> </glyph> <glyph class="state variable" id="_c31b6563-972b-4038-b9a6-bfbf7517837a"> <state value="P" variable="S980"/> <bbox w="35.0" h="10.0" x="18297.574" y="1636.5013"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s475_shh1_shh1_sa264" compartmentRef="shh1_shh1_c4_shh1_shh1_ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re84:(MAP:survival) The association of CyclinB and PTC occurs when cell is in G2/M arrest s_shh1_re85:(MAP:survival) PMID:11331587 s_shh1_re87(MAP:survival): PMID:11331587 PMID:16489008 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Cyclin B1 HUGO:CCNB1 HGNC:1579 ENTREZ:891 UNIPROT:P14635 GENECARDS:CCNB1 REACTOME:87210 KEGG:891 ATLASONC:CCNB1ID951ch5q13 WIKI:CCNB1 Identifiers_end Maps_Modules_begin: MAP:cellcycle / MODULE:CYCLINB MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11331587 PMID:16489008 References_end</body> </html> </notes> <label text="CyclinB*"/> <bbox w="80.0" h="40.0" x="19261.0" y="339.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s478_shh1_shh1_sa267" compartmentRef="shh1_shh1_c6_shh1_shh1_ca6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re87(MAP:survival): PMID:11331587 PMID:16489008 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Cyclin B1 HUGO:CCNB1 HGNC:1579 ENTREZ:891 UNIPROT:P14635 GENECARDS:CCNB1 REACTOME:87210 KEGG:891 ATLASONC:CCNB1ID951ch5q13 WIKI:CCNB1 Identifiers_end Maps_Modules_begin: MAP:cellcycle / MODULE:CYCLINB MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11331587 PMID:16489008 References_end</body> </html> </notes> <label text="CyclinB*"/> <bbox w="80.0" h="40.0" x="19267.5" y="1901.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s482_shh1_shh1_sa270" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re90(MAP:survival): References-begin: PMID:20818436 PMID:17115028 PMID:17312394 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 1 HUGO:GLI1 HGNC:4317 ENTREZ:2735 UNIPROT:P08151 GENECARDS:GLI1 KEGG:2735 ATLASONC:GLIID310ch12q13 WIKI:GLI1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI1"/> <bbox w="80.0" h="40.0" x="19256.25" y="2411.0"/> <glyph class="state variable" id="_8841c5b5-4ad3-4fb1-98f2-65259f2c76d2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19251.25" y="2406.0"/> </glyph> <glyph class="state variable" id="_3f823a70-e81c-419b-8077-5a29eeca1828"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="19246.25" y="2446.0"/> </glyph> <glyph class="state variable" id="_c2b124c1-9934-4de7-932c-612fea04bba5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19331.25" y="2406.0"/> </glyph> <glyph class="state variable" id="_a25a0936-620f-45bc-a8df-f5c2adbdc16c"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="19326.25" y="2446.0"/> </glyph> <glyph class="state variable" id="_e9e6fe3a-6fdc-4de0-9e29-1941f6d3bc9a"> <state value="" variable="T374"/> <bbox w="30.0" h="10.0" x="19320.63" y="2446.0"/> </glyph> <glyph class="state variable" id="_17c37734-da28-47f1-8499-ab1893aae569"> <state value="" variable="S640"/> <bbox w="30.0" h="10.0" x="19241.25" y="2445.7224"/> </glyph> <glyph class="state variable" id="_616fd413-0b9e-4d3f-a122-28b3f44ea42e"> <state value="" variable="K518"/> <bbox w="30.0" h="10.0" x="19264.225" y="2446.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s483_shh1_shh1_sa271" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re89(MAP:survival): PMID:20818436 PMID:17115028 PMID:17312394 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Itchy HUGO:ITCH HGNC:13890 ENTREZ:83737 UNIPROT:Q96J02 GENECARDS:ITCH REACTOME:93459 KEGG:83737 ATLASONC:GC_ITCH WIKI:ITCH Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18552861 E3 ubiquitin protein ligase homologue References_end</body> </html> </notes> <label text="ITCH"/> <bbox w="80.0" h="40.0" x="18866.0" y="2379.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s484_shh1_shh1_sa272" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re89(MAP:survival): PMID:20818436 PMID:17115028 PMID:17312394 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NUMB HUGO:NUMB HGNC:8060 ENTREZ:8650 UNIPROT:P49757 GENECARDS:NUMB REACTOME:60616 KEGG:8650 ATLASONC:NUMBID43702ch14q24 WIKI:NUMB Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20940030 References_end</body> </html> </notes> <label text="NUMB"/> <bbox w="80.0" h="40.0" x="18868.0" y="2445.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s497_shh1_shh1_sa279" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re92:(MAP:survival) PMID:18997815 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <bbox w="80.0" h="40.0" x="18008.5" y="2230.0"/> <glyph class="state variable" id="_c43702ab-fad9-408f-ad77-4970c76a1630"> <state value="Ub" variable="K257"/> <bbox w="40.0" h="10.0" x="17988.992" y="2225.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s498_shh1_shh1_sa282" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re92:(MAP:survival) PMID:18997815 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Ubiquitin protein ligase E3A HUGO:UBE3A HGNC:12496 ENTREZ:7337 UNIPROT:Q05086 GENECARDS:UBE3A REACTOME:66940 KEGG:7337 ATLASONC:UBE3AID42756ch15q11 WIKI:UBE3A ubiquitin protein ligase E3B HUGO:UBE3B HGNC:13478 ENTREZ:89910 UNIPROT:Q7Z3V4 GENECARDS:UBE3B REACTOME:253549 ATLASONC:GC_UBE3B WIKI:UBE3B ubiquitin protein ligase E3C HUGO:UBE3C HGNC:16803 ENTREZ:9690 UNIPROT:Q15386 GENECARDS:UBE3C REACTOME:253553 KEGG:9690 ATLASONC:GC_UBE3C WIKI:UBE3C ubiquitin protein ligase E3D HUGO:UBE3D HGNC:21381 ENTREZ:90025 UNIPROT:Q7Z6J8 GENECARDS:UBE3D KEGG:90025 WIKI:UBE3D Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16925947 Ubiquitin protein ligase PMID:18298802 References_end Identifiers_begin: Ubiquitin protein ligase E3A HUGO:UBE3A HGNC:12496 ENTREZ:7337 UNIPROT:Q05086 GENECARDS:UBE3A REACTOME:66940 KEGG:7337 ATLASONC:UBE3AID42756ch15q11 WIKI:UBE3A ubiquitin protein ligase E3B HUGO:UBE3B HGNC:13478 ENTREZ:89910 UNIPROT:Q7Z3V4 GENECARDS:UBE3B REACTOME:253549 ATLASONC:GC_UBE3B WIKI:UBE3B ubiquitin protein ligase E3C HUGO:UBE3C HGNC:16803 ENTREZ:9690 UNIPROT:Q15386 GENECARDS:UBE3C REACTOME:253553 KEGG:9690 ATLASONC:GC_UBE3C WIKI:UBE3C ubiquitin protein ligase E3D HUGO:UBE3D HGNC:21381 ENTREZ:90025 UNIPROT:Q7Z6J8 GENECARDS:UBE3D KEGG:90025 WIKI:UBE3D Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16925947 Ubiquitin protein ligase PMID:18298802 References_end</body> </html> </notes> <label text="E3*"/> <bbox w="80.0" h="40.0" x="18277.0" y="1155.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s499_shh1_shh1_sa283" compartmentRef="shh1_shh1_c6_shh1_shh1_ca6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 1 HUGO:GLI1 HGNC:4317 ENTREZ:2735 UNIPROT:P08151 GENECARDS:GLI1 KEGG:2735 ATLASONC:GLIID310ch12q13 WIKI:GLI1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI1"/> <bbox w="80.0" h="40.0" x="19256.5" y="2128.0"/> <glyph class="state variable" id="_4562368d-afe4-4abc-8682-adf9005a9bd5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19251.5" y="2123.0"/> </glyph> <glyph class="state variable" id="_7d4ec7ce-e6cf-422d-9534-330469eb7741"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19251.5" y="2163.0"/> </glyph> <glyph class="state variable" id="_98c67242-7f48-4811-a3a3-08807193e580"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19331.5" y="2123.0"/> </glyph> <glyph class="state variable" id="_b87aad69-2a94-4852-be78-9dff1c92ff9e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19331.5" y="2163.0"/> </glyph> <glyph class="state variable" id="_215d8a85-a1e7-4ad7-99be-51efa324ed9b"> <state value="" variable="T374"/> <bbox w="30.0" h="10.0" x="19320.88" y="2163.0"/> </glyph> <glyph class="state variable" id="_3ac7989e-f0f0-4a63-b55b-67916f8ff440"> <state value="" variable="S640"/> <bbox w="30.0" h="10.0" x="19241.5" y="2162.7224"/> </glyph> <glyph class="state variable" id="_8db03770-c334-411b-b191-9b796e7cf85a"> <state value="" variable="K518"/> <bbox w="30.0" h="10.0" x="19264.475" y="2163.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s508_shh1_shh1_sa289" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re97:(MAP:survival) PMID:18829525 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: SIL HUGO:STIL HGNC:10879 ENTREZ:6491 UNIPROT:Q15468 GENECARDS:STIL KEGG:6491 ATLASONC:SILID524ch1p32 WIKI:STIL Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:10385121 References_end</body> </html> </notes> <label text="SIL*"/> <bbox w="80.0" h="40.0" x="19383.0" y="2413.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s513_shh1_shh1_sa292" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re98:(MAP:survival) PMID:18829525 s_akt1_re6(MAP:survival): PMID:15534002 PMID:9779982 PMID:14585353 s_akt1_re11(MAP:survival): PMID:15584861 PMID:10648629 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end Identifiers_begin: RAS p21 protein activator (GTPase activating protein) 1 HUGO:RASA1 HGNC:9871 ENTREZ:5921 UNIPROT:P20936 GENECARDS:RASA1 REACTOME:63760 KEGG:5921 ATLASONC:GC_RASA1 WIKI:RASA1 RAS p21 protein activator 2 HUGO:RASA2 HGNC:9872 ENTREZ:5922 UNIPROT:Q15283 GENECARDS:RASA2 KEGG:5922 ATLASONC:GC_RASA2 WIKI:RASA2 RAS p21 protein activator 3 HUGO:RASA3 HGNC:20331 ENTREZ:22821 UNIPROT:Q14644 GENECARDS:RASA3 KEGG:22821 ATLASONC:GC_RASA3 WIKI:RASA3 RAS p21 protein activator 4 HUGO:RASA4 HGNC:23181 ENTREZ:10156 UNIPROT:O43374 GENECARDS:RASA4 KEGG:10156 WIKI:RASA4 v-Ha-ras Harvey rat sarcoma viral oncogene homolog HRAS1 HUGO:HRAS HGNC:5173 ENTREZ:3265 UNIPROT:P01112 GENECARDS:HRAS REACTOME:62718 KEGG:3265 ATLASONC:HRASID108 WIKI:HRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog KRAS2 "v-Ki-ras2 Kirsten rat sarcoma 2 viral oncogene homolog" HUGO:KRAS HGNC:6407 ENTREZ:3845 UNIPROT:P01116 GENECARDS:KRAS REACTOME:62720 KEGG:3845 ATLASONC:KRASID91 WIKI:KRAS neuroblastoma RAS viral (v-ras) oncogene homolog HUGO:NRAS HGNC:7989 ENTREZ:4893 UNIPROT:P01111 GENECARDS:NRAS REACTOME:62726 KEGG:4893 ATLASONC:NRASID92 WIKI:NRAS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21102635 RasGDP binds to Sos and RasGTP is generated. RasGTP keeps Sos inactive enhancing duration and amplitude of the output. RasGRP1 activates Golgi-associated Ras on this compartment. K-Ras is found exclusively at the PM. H- and N-Ras are also present in endomembrane compartments such as the endoplasmic reticulum and the Golgi apparatus. Processed K-Ras is confined primarily to the PM; however when its polybasic region is phosphorylated or targeted by Ca2+/calmodulin K-Ras relocalises to other endomembrane compartments including Golgi endoplasmic reticulum and mitochondria. In contrast H-Ras and N-Ras constantly shuttle between the Golgi and PM as a result of a constitutive depalmitoylation/repalmitoylation cycle. H-Ras but not K-Ras signalling was dependent on endocytosis. PMID:17496910 PMID:16488589 PMID:12782630 PMID:17496910 PMID:19615955 References_end</body> </html> </notes> <label text="RAS*"/> <bbox w="80.0" h="40.0" x="19514.0" y="2402.0"/> <glyph class="state variable" id="_76cd3507-d776-4ac8-9c00-14b73f969814"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19509.0" y="2417.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s516_shh1_shh1_sa294" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re99(MAP:survival): PMID:19575820 PMID:17052453 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end Identifiers_begin: glycogen synthase kinase 3 beta HUGO:GSK3B HGNC:4617 ENTREZ:2932 UNIPROT:P49841 GENECARDS:GSK3B REACTOME:404223 ATLASONC:GSK3BID40761ch3q13 WIKI:GSK3B Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:MOMP_REGULATION MAP:cellcycle / MODULE:CYCLIND MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12615961 PMID:20537194 glycogen synthase kinase 3 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end</body> </html> </notes> <label text="GSK3β*"/> <bbox w="80.0" h="40.0" x="18917.5" y="770.0"/> <glyph class="state variable" id="_53b6acca-126b-403a-b367-4b8505958b66"> <state value="" variable="S9"/> <bbox w="20.0" h="10.0" x="18907.992" y="765.0"/> </glyph> <glyph class="state variable" id="_e0544dbf-e2f7-425c-b6dc-21eb619d4dda"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18912.5" y="785.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s559_shh1_shh1_sa321" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re108:(MAP:survival) PMID:20889716 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Tubby like protein 3 HUGO:TULP3 HGNC:12425 ENTREZ:7289 UNIPROT:O75386 GENECARDS:TULP3 KEGG:7289 ATLASONC:GC_TULP3 WIKI:TULP3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20889716 PMID:19286674 PMID:19334287 References_end</body> </html> </notes> <label text="TULP3"/> <bbox w="80.0" h="40.0" x="19585.0" y="1597.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s565_shh1_shh1_sa326" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re110:(MAP:survival) PMID:20889716 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Dynein cytoplasmic 1 heavy chain 1 HUGO:DYNC1H1 HGNC:2961 ENTREZ:1778 UNIPROT:Q14204 GENECARDS:DYNC1H1 REACTOME:54006 KEGG:1778 WIKI:DYNC1H1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20889716 References_end</body> </html> </notes> <label text="DYN1*"/> <bbox w="80.0" h="40.0" x="19435.0" y="1108.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s566_shh1_shh1_sa327" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re35(MAP:survival): PMID:18497258 PMID:11449277 PMID:20375059 Rad23 negatively regulates SHH signaling but how exactly is unknown. Recently it was shown to be associated with Smo trafficing into cilium References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: RAB23 member of RAS oncogen family HUGO:RAB23 HGNC:14263 ENTREZ:51715 UNIPROT:Q9ULC3 GENECARDS:RAB23 KEGG:51715 ATLASONC:GC_RAB23 WIKI:RAB23 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20375059 PMID:11449277 References_end</body> </html> </notes> <label text="RAB23"/> <bbox w="80.0" h="40.0" x="18956.0" y="491.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s577_shh1_shh1_sa174" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re36(MAP:survival): PMID:20956384 PMID:19592253 PMID:0643644 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Kinesin family member 7 HUGO:KIF7 HGNC:30497 ENTREZ:374654 UNIPROT:Q2M1P5 GENECARDS:KIF7 KEGG:374654 WIKI:KIF7 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19666503 PMID:19906571 PMID:19592253 PMID:19549984 References_end</body> </html> </notes> <label text="KIF7"/> <bbox w="80.0" h="40.0" x="18001.0" y="322.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh1_s515_shh1_shh1_sa295" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19575820 s_shh1_re99(MAP:survival): PMID:17052453 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ribosomal protein S6 kinase 70kDa polypeptide 2 HUGO:RPS6KB2 HGNC:10437 ENTREZ:6199 UNIPROT:Q9UBS0 GENECARDS:RPS6KB2 REACTOME:57805 KEGG:6199 ATLASONC:GC_RPS6KB2 WIKI:RPS6KB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20932932 PMID:20647036 References_end Identifiers_begin: ribosomal protein S6 kinase 70kDa polypeptide 2 HUGO:RPS6KB2 HGNC:10437 ENTREZ:6199 UNIPROT:Q9UBS0 GENECARDS:RPS6KB2 REACTOME:57805 KEGG:6199 ATLASONC:GC_RPS6KB2 WIKI:RPS6KB2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20932932 PMID:20647036 References_end</body> </html> </notes> <label text="p70β*"/> <bbox w="80.0" h="40.0" x="18854.0" y="674.0"/> <glyph class="state variable" id="_75fe5246-e9b2-4b72-9b64-1fa5caa6e055"> <state value="" variable="T388"/> <bbox w="30.0" h="10.0" x="18918.38" y="709.0"/> </glyph> <glyph class="state variable" id="_731c93fa-35e0-4044-bf81-6eae3aca3e74"> <state value="" variable="T228"/> <bbox w="30.0" h="10.0" x="18839.492" y="669.0"/> </glyph> </glyph> <glyph class="simple chemical" id="shh1_s_shh1_s320_shh1_shh1_sa173" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Forskolin CAS:66575-29-9 PUBCHEM:47936 KEGGDRUG:DB02587 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh1_re43:(MAP:survival) PMID:21209912 References_end</body> </html> </notes> <label text="Forskolin"/> <bbox w="70.0" h="25.0" x="18799.0" y="627.5"/> </glyph> <glyph class="simple chemical" id="shh1_s_shh1_s2_shh1_shh1_sa2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Hedgehog ligand molecule s_shh1_re79(MAP:survival): PMID:10050855 PMID:16571352 s_shh1_re80:(MAP:survival) PMID:18477453 References_end</body> </html> </notes> <label text="HH Ligand"/> <bbox w="70.0" h="25.0" x="19541.0" y="51.5"/> </glyph> <glyph class="simple chemical" id="shh1_s_shh1_s583_shh1_shh1_sa338" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re26(MAP:survival): PMID:10021362 PMID:18815277 PMID:17430994 s_shh3_re5(MAP:survival): PMID:16885213 PMID:21474452 PMID:20081366 s_wnc1_re8:(MAP:survival) PMID:11694535 References_end</body> </html> </notes> <label text="GTP"/> <clone/> <bbox w="30.0" h="30.0" x="18617.0" y="330.5"/> </glyph> <glyph class="simple chemical" id="shh1_s_shh1_s583_shh1_shh3_sa35" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re26(MAP:survival): PMID:10021362 PMID:18815277 PMID:17430994 s_shh3_re5(MAP:survival): PMID:16885213 PMID:21474452 PMID:20081366 s_wnc1_re8:(MAP:survival) PMID:11694535 References_end</body> </html> </notes> <label text="GTP"/> <clone/> <bbox w="30.0" h="30.0" x="18549.0" y="5168.5"/> </glyph> <glyph class="simple chemical" id="shh1_s_shh1_s583_shh1_shh3_sa80" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re26(MAP:survival): PMID:10021362 PMID:18815277 PMID:17430994 s_shh3_re5(MAP:survival): PMID:16885213 PMID:21474452 PMID:20081366 s_wnc1_re8:(MAP:survival) PMID:11694535 References_end</body> </html> </notes> <label text="GTP"/> <clone/> <bbox w="30.0" h="30.0" x="20083.5" y="5317.0"/> </glyph> <glyph class="simple chemical" id="shh1_s_shh1_s584_shh1_shh1_sa339" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re26(MAP:survival): PMID:10021362 PMID:18815277 PMID:17430994 s_shh3_re5(MAP:survival): PMID:16885213 PMID:21474452 PMID:20081366 s_wnc1_re8:(MAP:survival) PMID:11694535 References_end</body> </html> </notes> <label text="GDP"/> <clone/> <bbox w="30.0" h="30.0" x="18540.5" y="348.0"/> </glyph> <glyph class="simple chemical" id="shh1_s_shh1_s584_shh1_shh3_sa36" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re26(MAP:survival): PMID:10021362 PMID:18815277 PMID:17430994 s_shh3_re5(MAP:survival): PMID:16885213 PMID:21474452 PMID:20081366 s_wnc1_re8:(MAP:survival) PMID:11694535 References_end</body> </html> </notes> <label text="GDP"/> <clone/> <bbox w="30.0" h="30.0" x="18444.0" y="5167.5"/> </glyph> <glyph class="simple chemical" id="shh1_s_shh1_s584_shh1_shh3_sa79" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re26(MAP:survival): PMID:10021362 PMID:18815277 PMID:17430994 s_shh3_re5(MAP:survival): PMID:16885213 PMID:21474452 PMID:20081366 s_wnc1_re8:(MAP:survival) PMID:11694535 References_end</body> </html> </notes> <label text="GDP"/> <clone/> <bbox w="30.0" h="30.0" x="20141.5" y="5317.0"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s290_shh1_shh2_sa253" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re143:(MAP:survival) PMID:19351822 s_shh2_re149(MAP:survival): PMID:16878133 PMID:18550634 Not known which miRNA of the miR-17-92 polycistron is reponsible for degradation of Tsp1 and CTGF not known which miRNA is responsible therefor miR-17-3p is shown in complex s_shh2_re150(MAP:survival): Not known which miRNA of the miR-17-92 polycistron is reponsible for degradation of Tsp1 and CTGF therefor only miR-17-3p shown in complex References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 17 HUGO:MIR17 HGNC:31547 ENTREZ:406952 GENECARDS:MIR17 KEGG:406952 ATLASONC:GC_MIR17 WIKI:MIR17 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20851997 References_end</body> </html> </notes> <label text="MIR17-3P*"/> <bbox w="90.0" h="25.0" x="19234.0" y="4495.5"/> <glyph class="unit of information" id="_815797b6-1797-424e-a5ee-676f030b5dfb"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="19264.0" y="4490.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s280_shh1_shh2_sa244" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re135:(MAP:survival) PMID:20851997 PMID:19351822 s_shh2_re144:(MAP:survival) PMID:15944709 s_shh2_re146:(MAP:survival) PMID18493594 s_shh2_re151(MAP:survival): PMID:18700987 The miR-17-5p drives the cell from G1 to S phase thereby regulating more than 20 genes s_shh2_re152:(MAP:survival) PMID:21383238 s_shh2_re154:(MAP:survival) PMID:18695042 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 17 HUGO:MIR17 HGNC:31547 ENTREZ:406952 GENECARDS:MIR17 KEGG:406952 ATLASONC:GC_MIR17 WIKI:MIR17 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20851997 References_end</body> </html> </notes> <label text="MIR17-5P*"/> <bbox w="90.0" h="25.0" x="19234.0" y="4532.0"/> <glyph class="unit of information" id="_02b7f19a-ffd4-4773-85a1-006ceb919db4"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="19264.0" y="4527.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s282_shh1_shh2_sa246" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re137:(MAP:survival) PMID:20851997 PMID:19351822 s_shh2_re157:(MAP:survival) PMID:19684618 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 18a HUGO:MIR18A HGNC:31548 ENTREZ:406953 GENECARDS:MIR18A KEGG:406953 ATLASONC:GC_MIR18A WIKI:MIR18A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20851997 References_end</body> </html> </notes> <label text="MIR18A"/> <bbox w="90.0" h="25.0" x="19234.0" y="4605.0"/> <glyph class="unit of information" id="_6664e49e-5b91-4e03-b71a-bfa3546d6fc1"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="19264.0" y="4600.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s283_shh1_shh2_sa247" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re138:(MAP:survival) PMID:20851997 PMID:19351822 s_shh2_re156:(MAP:survival) PMID:21271217 s_shh2_re158:(MAP:survival) PMID:18460397 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 19a HUGO:MIR19A HGNC:31574 ENTREZ:406979 GENECARDS:MIR19A KEGG:406979 ATLASONC:GC_MIR19A WIKI:MIR19A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20851997 References_end</body> </html> </notes> <label text="MIR19A"/> <bbox w="90.0" h="25.0" x="19234.0" y="4641.5"/> <glyph class="unit of information" id="_d67ca25e-6e3c-4633-b1e0-9558a217129d"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="19264.0" y="4636.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s284_shh1_shh2_sa248" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re139:(MAP:survival) PMID:20851997 PMID:19351822 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 19B1 HUGO:MIR19B1 HGNC:31575 ENTREZ:406980 GENECARDS:MIR19B1 KEGG:406980 ATLASONC:GC_MIR19B1 WIKI:MIR19B1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20851997 References_end</body> </html> </notes> <label text="MIR19B1"/> <bbox w="90.0" h="25.0" x="19234.0" y="4678.0"/> <glyph class="unit of information" id="_88666ba4-e870-4ef5-a61a-f78529c2f4c5"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="19264.0" y="4673.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s281_shh1_shh2_sa245" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re136:(MAP:survival) PMID:20851997 PMID:19351822 s_shh2_re153:(MAP:survival) PMID:21383238 s_shh2_re155:(MAP:survival) PMID:18695042 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 20a HUGO:MIR20A HGNC:31577 ENTREZ:406982 GENECARDS:MIR20A KEGG:406982 ATLASONC:GC_MIR20A WIKI:MIR20A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20851997 References_end</body> </html> </notes> <label text="MIR20A"/> <bbox w="90.0" h="25.0" x="19234.0" y="4568.5"/> <glyph class="unit of information" id="_f6148cdd-a0a6-442e-9444-c1e420e8b848"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="19264.0" y="4563.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s245_shh1_shh2_sa213" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re121(MAP:survival): PMID:20564213 ANNOTATION: Not clear how suprresion is regulated by Hedgehog s_shh2_re123:(MAP:survival) PMID:21359530 s_shh2_re130:(MAP:survival) PMID:21245165 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 29b-1 HUGO:MIR29B1 HGNC:31619 ENTREZ:407024 GENECARDS:MIR29B1 KEGG:407024 ATLASONC:GC_MIR29B1 WIKI:MIR29B1 HUGO:MIR29B*1 HGNC:31619 ENTREZ:407024 GENECARDS:MIR29B*1 WIKI:MIR29B*1 microRNA 29b-2 HUGO:MIR29B2 HGNC:31620 ENTREZ:407025 GENECARDS:MIR29B2 KEGG:407025 ATLASONC:GC_MIR29B2 WIKI:MIR29B2 HUGO:MIR29B*2 HGNC:31620 ENTREZ:407025 GENECARDS:MIR29B*2 WIKI:MIR29B*2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21359530 References_end</body> </html> </notes> <label text="MIR29B*"/> <bbox w="90.0" h="25.0" x="18842.0" y="4601.5"/> <glyph class="unit of information" id="_5eecf704-7158-4689-a4a2-6ef6ad1a90ae"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="18872.0" y="4596.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s198_shh1_shh2_sa177" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re122:(MAP:survival) PMID:19351822 s_shh2_re159:(MAP:survival) PMID:18077375 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 378 HUGO:MIR378 GENECARDS:MIR378 KEGG:494327 WIKI:MIR378 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19446450 PMID:18077375 References_end</body> </html> </notes> <label text="MIR378"/> <clone/> <bbox w="90.0" h="25.0" x="19915.0" y="3932.5"/> <glyph class="unit of information" id="_ad025a44-b849-4a2b-a197-82f5e1f997fd"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="19945.0" y="3927.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s198_shh1_shh2_sa217" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re122:(MAP:survival) PMID:19351822 s_shh2_re159:(MAP:survival) PMID:18077375 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 378 HUGO:MIR378 GENECARDS:MIR378 KEGG:494327 WIKI:MIR378 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19446450 PMID:18077375 References_end</body> </html> </notes> <label text="MIR378"/> <clone/> <bbox w="90.0" h="25.0" x="18842.0" y="4645.5"/> <glyph class="unit of information" id="_b7fd96f6-9c82-4953-9d3b-1d356f4da6d2"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="18872.0" y="4640.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s285_shh1_shh2_sa249" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re140:(MAP:survival) PMID:20851997 PMID:19351822 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 92 a1 HUGO:MIR92A1 HGNC:31643 ENTREZ:407048 GENECARDS:MIR92A1 KEGG:407048 ATLASONC:GC_MIR92A1 WIKI:MIR92A1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20851997 References_end</body> </html> </notes> <label text="MIR92A1"/> <bbox w="90.0" h="25.0" x="19234.0" y="4714.5"/> <glyph class="unit of information" id="_48d0ffc9-fa53-4d7a-a87d-54c210b42f98"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="19264.0" y="4709.5"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s337_shh1_shh2_csa5" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GLI1:promoter_region Identifiers_end References_begin: s_shh2_re12:(MAP:survival) PMID:12138125 s_shh2_re15:(MAP:survival) PMID:17035233 PMID:16328026 s_shh2_re22:(MAP:survival) PMID:18813803 PMID:16880536 PMID:19190345 s_shh2_re42:(MAP:survival) PMID:16396903 PMID:20107231 PMID:16054035 PMID:16406505 PMID:16880536 PMID:17000779 s_shh2_re45:(MAP:survival) PMID:15087129 s_shh2_re53:(MAP:survival) PMID:21059263 s_shh2_re57:(MAP:survival) PMID:19736394 s_shh2_re58:(MAP:survival) PMID:15520176 PMID:14555646 s_shh2_re73:(MAP:survival) PMID:16571352 s_shh2_re77:(MAP:survival) PMID:16158046 s_shh2_re81:(MAP:survival) PMID:11960000 s_shh2_re82:(MAP:survival) PMID:19219074 s_shh2_re86:(MAP:survival) PMID:19190345 PMID:16880536 s_shh2_re102(MAP:survival): PMID:21442356 Not sure if direct interaction of gli1 with gene References_end</body> </html> </notes> <label text="(GLI1_DNA_binding_site)"/> <bbox w="100.0" h="120.0" x="18466.0" y="3251.0"/> <glyph class="nucleic acid feature" id="shh1_shh2_s35_shh1_shh2_sa29"> <label text="promoter_region"/> <bbox w="70.0" h="25.0" x="18481.5" y="3308.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh2_s36_shh1_shh2_sa30"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 1 HUGO:GLI1 HGNC:4317 ENTREZ:2735 UNIPROT:P08151 GENECARDS:GLI1 KEGG:2735 ATLASONC:GLIID310ch12q13 WIKI:GLI1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI1"/> <bbox w="80.0" h="40.0" x="18476.5" y="3262.0"/> <glyph class="state variable" id="_1ab58255-7344-4637-997a-268c8e7ec757"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="18469.0" y="3257.0"/> </glyph> <glyph class="state variable" id="_69ff197f-bd2e-4feb-bcf1-b1b7fd846437"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18471.5" y="3297.0"/> </glyph> <glyph class="state variable" id="_04169772-e277-454f-8e95-283c51ea693a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="18549.0" y="3257.0"/> </glyph> <glyph class="state variable" id="_3eeafcfd-44d5-4d10-980d-fb0ef058d75f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18551.5" y="3297.0"/> </glyph> <glyph class="state variable" id="_b324b55a-00fb-4663-930c-93c280f3412a"> <state value="" variable="T374"/> <bbox w="30.0" h="10.0" x="18540.88" y="3297.0"/> </glyph> <glyph class="state variable" id="_47e6c2ec-f1b7-4293-996c-d10a23633efb"> <state value="" variable="S640"/> <bbox w="30.0" h="10.0" x="18461.5" y="3296.7224"/> </glyph> <glyph class="state variable" id="_0ef42859-258f-4607-99d3-4ffc941f2dc8"> <state value="" variable="K518"/> <bbox w="30.0" h="10.0" x="18484.475" y="3297.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s338_shh1_shh2_csa16" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GLI1:JUN:promoter_region Identifiers_end References_begin: s_shh2_re22:(MAP:survival) PMID:18813803 PMID:16880536 PMID:19190345 s_shh2_re36:(MAP:survival) PMID:16880536 PMID:18813803 PMID:19190345 s_shh2_re42:(MAP:survival) PMID:16396903 PMID:20107231 PMID:16054035 PMID:16406505 PMID:16880536 PMID:17000779 s_shh2_re82:(MAP:survival) PMID:19219074 s_shh2_re86:(MAP:survival) PMID:19190345 PMID:16880536 References_end</body> </html> </notes> <label text="(GLI1_JUN_DNA_binding_site)"/> <bbox w="100.0" h="163.0" x="18551.0" y="4123.0"/> <glyph class="macromolecule" id="shh1_shh2_s180_shh1_shh2_sa159"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 1 HUGO:GLI1 HGNC:4317 ENTREZ:2735 UNIPROT:P08151 GENECARDS:GLI1 KEGG:2735 ATLASONC:GLIID310ch12q13 WIKI:GLI1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI1"/> <bbox w="80.0" h="40.0" x="18559.0" y="4142.0"/> <glyph class="state variable" id="_1cc1433c-6e2c-401c-9f72-d5287761bfc0"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="18551.5" y="4137.0"/> </glyph> <glyph class="state variable" id="_13ad0709-c12b-445f-840d-1cf8e2cca8fe"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18554.0" y="4177.0"/> </glyph> <glyph class="state variable" id="_f1aa6f14-28f6-4b06-ab87-fa77b65aee85"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="18631.5" y="4137.0"/> </glyph> <glyph class="state variable" id="_0cbcc652-6438-461e-871d-4b49274c4663"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18634.0" y="4177.0"/> </glyph> <glyph class="state variable" id="_cb5dc21f-191b-49b6-94cd-4434ce3bcbf7"> <state value="" variable="T374"/> <bbox w="30.0" h="10.0" x="18623.38" y="4177.0"/> </glyph> <glyph class="state variable" id="_8c1bc9cb-6980-4cdc-90d4-727e6cbcca8c"> <state value="" variable="S640"/> <bbox w="30.0" h="10.0" x="18544.0" y="4176.722"/> </glyph> <glyph class="state variable" id="_e29ded2d-ead3-4d74-aa8b-cac1a589ee06"> <state value="" variable="K518"/> <bbox w="30.0" h="10.0" x="18566.975" y="4177.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_shh2_s178_shh1_shh2_sa160"> <label text="promoter_region"/> <bbox w="70.0" h="25.0" x="18564.0" y="4191.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh2_s179_shh1_shh2_sa161"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> </notes> <label text="JUN"/> <bbox w="80.0" h="40.0" x="18561.875" y="4222.0"/> <glyph class="state variable" id="_facaab23-d78c-433e-819e-48060dcc845c"> <state value="P" variable="S63"/> <bbox w="30.0" h="10.0" x="18547.367" y="4217.0"/> </glyph> <glyph class="state variable" id="_6e530603-fc24-4f1b-b964-d101b7b35bc2"> <state value="P" variable="S73"/> <bbox w="30.0" h="10.0" x="18586.906" y="4217.0"/> </glyph> <glyph class="state variable" id="_86e8c108-f5e8-4ab2-89fc-69e517882794"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18556.875" y="4237.0"/> </glyph> <glyph class="state variable" id="_1dd41b5e-1246-4e6a-854c-74474daaf471"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18556.875" y="4217.0"/> </glyph> <glyph class="state variable" id="_e919a6b5-74ea-49c7-a819-205d69b7743b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18556.875" y="4257.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s336_shh1_shh2_csa2" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GLI3-83_sub_TRUNC_endsub_*:HDAC3:SKI:promoter_region Identifiers_end References_begin: s_shh2_re3:(MAP:survival) PMID:12435627 PMID:19032343 s_shh2_re4:(MAP:survival) PMID:20562908 s_shh2_re42:(MAP:survival) PMID:16396903 PMID:20107231 PMID:16054035 PMID:16406505 PMID:16880536 PMID:17000779 s_shh2_re45:(MAP:survival) PMID:15087129 s_shh2_re51(MAP:survival): PMID:9216996 PMID:16413481 PMID:17000779 ANNOTATION: it was shown that Med12 binds to Gli1 promoter s_shh2_re104:(MAP:survival) PMID:19809516 s_shh2_re106:(MAP:survival) PMID:16169709 References_end</body> </html> </notes> <label text="(GLI3R_DNA_binding_site)"/> <bbox w="177.0" h="143.0" x="18422.0" y="3101.5"/> <glyph class="macromolecule" id="shh1_shh2_s17_shh1_shh2_sa12"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 3 HUGO:GLI3 HGNC:4319 ENTREZ:2737 UNIPROT:P10071 GENECARDS:GLI3 KEGG:2737 ATLASONC:GC_GLI3 WIKI:GLI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI3-83TRUNC*"/> <bbox w="80.0" h="40.0" x="18471.75" y="3111.25"/> <glyph class="unit of information" id="_0feea459-3c01-461e-a92a-ef26934ad258"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="18486.75" y="3106.25"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_shh2_s16_shh1_shh2_sa13"> <label text="promoter_region"/> <bbox w="70.0" h="25.0" x="18474.0" y="3155.75"/> </glyph> <glyph class="macromolecule" id="shh1_shh2_s228_shh1_shh2_sa202"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Ski HUGO:SKI HGNC:10896 ENTREZ:6497 UNIPROT:P12755 GENECARDS:SKI REACTOME:64528 KEGG:6497 ATLASONC:GC_SKI WIKI:SKI Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19114989 V-ski sarcoma viral oncogene homologue (avian) References_end</body> </html> </notes> <label text="SKI"/> <bbox w="80.0" h="40.0" x="18511.0" y="3185.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh2_s229_shh1_shh2_sa203"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Histone deacetylase 3 HUGO:HDAC3 HGNC:4854 ENTREZ:8841 UNIPROT:O15379 GENECARDS:HDAC3 REACTOME:401336 KEGG:8841 ATLASONC:HDAC3ID40804ch5q31 WIKI:HDAC3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21234400 Histone deacetylase References_end</body> </html> </notes> <label text="HDAC3"/> <bbox w="80.0" h="40.0" x="18429.0" y="3185.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s335_shh1_shh2_csa13" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:JUN:promoter_region Identifiers_end References_begin: s_shh2_re84:(MAP:survival) PMID:19219074 s_shh2_re22:(MAP:survival) PMID:18813803 PMID:16880536 PMID:19190345 s_shh2_re36:(MAP:survival) PMID:16880536 PMID:18813803 PMID:19190345 s_shh2_re42:(MAP:survival) PMID:16396903 PMID:20107231 PMID:16054035 PMID:16406505 PMID:16880536 PMID:17000779 s_shh2_re86:(MAP:survival) PMID:19190345 PMID:16880536 References_end</body> </html> </notes> <label text="(JUN_gene)"/> <bbox w="100.0" h="120.0" x="18466.0" y="2960.0"/> <glyph class="macromolecule" id="shh1_shh2_s147_shh1_shh2_sa133"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> </notes> <label text="JUN"/> <bbox w="80.0" h="40.0" x="18477.656" y="2981.0"/> <glyph class="state variable" id="_27853a5a-7702-47e5-b9fb-c4df713f384a"> <state value="P" variable="S63"/> <bbox w="30.0" h="10.0" x="18463.148" y="2976.0"/> </glyph> <glyph class="state variable" id="_e311de84-5e0c-4b05-8ad2-484b5a68ebc3"> <state value="P" variable="S73"/> <bbox w="30.0" h="10.0" x="18502.688" y="2976.0"/> </glyph> <glyph class="state variable" id="_20431e3e-1224-44c0-9268-963081c163fa"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18472.656" y="2996.0"/> </glyph> <glyph class="state variable" id="_1ff7357a-1b48-4965-8458-f25ea8e08251"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18472.656" y="2976.0"/> </glyph> <glyph class="state variable" id="_6477cb91-bfd6-4eca-b7db-3af514fcee96"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18472.656" y="3016.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_shh2_s148_shh1_shh2_sa134"> <label text="promoter_region"/> <bbox w="70.0" h="25.0" x="18483.938" y="3024.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s104_shh1_shh2_csa8" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:GLI1 Identifiers_end References_begin: s_shh2_re62:(MAP:survival) PMID:19996099 References_end</body> </html> </notes> <label text="GLI1_14-3-3"/> <bbox w="100.0" h="120.0" x="18469.0" y="3650.0"/> <glyph class="macromolecule" id="shh1_shh2_s105_shh1_shh2_sa94"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="18477.5" y="3656.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh2_s106_shh1_shh2_sa95"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 1 HUGO:GLI1 HGNC:4317 ENTREZ:2735 UNIPROT:P08151 GENECARDS:GLI1 KEGG:2735 ATLASONC:GLIID310ch12q13 WIKI:GLI1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI1"/> <bbox w="80.0" h="40.0" x="18476.75" y="3699.0"/> <glyph class="state variable" id="_cbbf25cc-7c8e-4155-8905-29b808d613ed"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18471.75" y="3694.0"/> </glyph> <glyph class="state variable" id="_18c5f999-b2ca-4f72-8599-1b83ed1e2574"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18471.75" y="3734.0"/> </glyph> <glyph class="state variable" id="_4e24f46c-272b-4f0b-a6df-edb6ad14d67c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18551.75" y="3694.0"/> </glyph> <glyph class="state variable" id="_4264d3da-a982-4cd9-bbad-23cc3a34ac69"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18551.75" y="3734.0"/> </glyph> <glyph class="state variable" id="_10043b70-d5c8-4a02-af96-6f1c38dfc372"> <state value="" variable="T374"/> <bbox w="30.0" h="10.0" x="18541.13" y="3734.0"/> </glyph> <glyph class="state variable" id="_e8d168be-dd59-4335-b82c-fc0c7bfe7404"> <state value="P" variable="S640"/> <bbox w="35.0" h="10.0" x="18459.25" y="3733.7224"/> </glyph> <glyph class="state variable" id="_be66a32a-5588-4bb0-9974-71b5edc58872"> <state value="" variable="K518"/> <bbox w="30.0" h="10.0" x="18484.725" y="3734.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s110_shh1_shh2_csa9" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:GLI2-185* Identifiers_end References_begin: s_shh2_re65:(MAP:survival) PMID:19996099 References_end</body> </html> </notes> <label text="GLI2-185_14-3-3"/> <bbox w="191.0" h="139.0" x="19580.0" y="3718.75"/> <glyph class="macromolecule" id="shh1_shh2_s111_shh1_shh2_sa99"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 2 HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Glioma-associated oncogene family zinc finger PMID:18497536 PMID:17845852 PMID:11001584 References_end</body> </html> </notes> <label text="GLI2-185*"/> <bbox w="165.0" h="45.0" x="19592.75" y="3781.75"/> <glyph class="state variable" id="_bfe47fb3-65e6-465b-961c-a71199a93e42"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19642.982" y="3776.75"/> </glyph> <glyph class="state variable" id="_4ebd5742-c41d-48f7-a3d3-a5d7b716a8af"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="19681.979" y="3776.75"/> </glyph> <glyph class="state variable" id="_f2420c96-c580-4db0-a8aa-ab00a82c2284"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19691.105" y="3821.75"/> </glyph> <glyph class="state variable" id="_1cc40e89-268e-446e-94be-e8c312855ab4"> <state value="" variable="S801"/> <bbox w="30.0" h="10.0" x="19646.156" y="3776.75"/> </glyph> <glyph class="state variable" id="_3d1dd46a-7001-41e1-ae4d-85bb3e451587"> <state value="" variable="K757"/> <bbox w="30.0" h="10.0" x="19577.75" y="3790.74"/> </glyph> <glyph class="state variable" id="_6269264e-6aad-47a8-901c-17176013b720"> <state value="P" variable="S956"/> <bbox w="35.0" h="10.0" x="19575.25" y="3821.4375"/> </glyph> <glyph class="state variable" id="_b072a914-f992-4b3a-8367-c0dc26606997"> <state value="" variable="S817"/> <bbox w="30.0" h="10.0" x="19741.475" y="3821.75"/> </glyph> <glyph class="state variable" id="_495f8412-03bf-4712-89b2-aa9b8f90c64c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19670.25" y="3776.75"/> </glyph> <glyph class="state variable" id="_01e075a4-cf82-4dd7-86d2-dc90a1a9a61d"> <state value="" variable="S847"/> <bbox w="30.0" h="10.0" x="19628.97" y="3821.75"/> </glyph> <glyph class="state variable" id="_8ae67119-d5e7-4550-b0c8-d77ff6faedd7"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="19577.75" y="3799.214"/> </glyph> <glyph class="state variable" id="_5e9e1b2d-bbfe-4daa-98cd-e247e722e995"> <state value="" variable="S789"/> <bbox w="30.0" h="10.0" x="19577.75" y="3790.2217"/> </glyph> <glyph class="state variable" id="_4bd762aa-0e57-4636-aae8-d72a76c20967"> <state value="" variable="S1011"/> <bbox w="35.0" h="10.0" x="19575.25" y="3807.1687"/> </glyph> <glyph class="state variable" id="_85d83f6c-d878-42a6-a107-7b9f1ef48b3b"> <state value="" variable="S805"/> <bbox w="30.0" h="10.0" x="19681.385" y="3776.75"/> </glyph> <glyph class="state variable" id="_57aacb6b-82fe-4d9a-ab1b-1b31e1bbdbbc"> <state value="" variable="S820"/> <bbox w="30.0" h="10.0" x="19706.139" y="3821.75"/> </glyph> <glyph class="state variable" id="_90251700-f99a-4f62-9868-e1ea514740ad"> <state value="" variable="S813"/> <bbox w="30.0" h="10.0" x="19742.75" y="3799.3218"/> </glyph> <glyph class="state variable" id="_eb5523a0-a6ee-464c-b6f9-2d70b09238e9"> <state value="" variable="S850"/> <bbox w="30.0" h="10.0" x="19577.75" y="3820.5671"/> </glyph> <glyph class="state variable" id="_c313903f-68e0-4f76-986e-1fc86b27af4e"> <state value="" variable="S844"/> <bbox w="30.0" h="10.0" x="19655.096" y="3821.75"/> </glyph> <glyph class="state variable" id="_31bf6295-4bf9-4e50-8989-95d821c9c724"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="19578.766" y="3776.75"/> </glyph> <glyph class="state variable" id="_a5de62d9-ad56-426d-b4c9-3256870493f2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19691.105" y="3821.75"/> </glyph> <glyph class="state variable" id="_8e6a0bbb-2bdd-4afc-936c-8be096adb0ba"> <state value="" variable="S808"/> <bbox w="30.0" h="10.0" x="19741.994" y="3776.75"/> </glyph> <glyph class="state variable" id="_c268b8aa-f630-4fe2-9ba9-9a821da549b0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19631.49" y="3776.75"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh2_s112_shh1_shh2_sa100"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="19637.5" y="3729.75"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s113_shh1_shh2_csa10" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:14-3-3*:GLI3-190* Identifiers_end References_begin: s_shh2_re66:(MAP:survival) PMID:19996099 References_end</body> </html> </notes> <label text="GLI3-190_14-3-3"/> <bbox w="195.0" h="147.0" x="20026.75" y="3714.75"/> <glyph class="macromolecule" id="shh1_shh2_s114_shh1_shh2_sa101"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <bbox w="80.0" h="40.0" x="20082.25" y="3722.75"/> </glyph> <glyph class="macromolecule" id="shh1_shh2_s115_shh1_shh2_sa102"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 3 HUGO:GLI3 HGNC:4319 ENTREZ:2737 UNIPROT:P10071 GENECARDS:GLI3 KEGG:2737 ATLASONC:GC_GLI3 WIKI:GLI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI3-190*"/> <bbox w="165.0" h="45.0" x="20039.5" y="3771.75"/> <glyph class="state variable" id="_34e030c7-a790-4765-a09f-00720e0b80af"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20066.51" y="3766.75"/> </glyph> <glyph class="state variable" id="_d6c2a628-79fa-429b-b73d-e2fbbe8e77da"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20086.021" y="3766.75"/> </glyph> <glyph class="state variable" id="_ea33077c-7906-4cbd-bd75-626919015042"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20099.484" y="3766.75"/> </glyph> <glyph class="state variable" id="_10be10b7-90f8-4f71-95b2-5cad3e5a3c35"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20137.855" y="3811.75"/> </glyph> <glyph class="state variable" id="_2c5e4bd4-a8c8-4958-86c4-1c9dee1e5be2"> <state value="" variable="S860"/> <bbox w="30.0" h="10.0" x="20124.652" y="3766.75"/> </glyph> <glyph class="state variable" id="_7858c607-c313-4d12-b057-02d854c57b3f"> <state value="" variable="S907"/> <bbox w="30.0" h="10.0" x="20071.887" y="3811.75"/> </glyph> <glyph class="state variable" id="_c966711e-56f3-4e33-adfc-d2f76a1c1da6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20066.51" y="3766.75"/> </glyph> <glyph class="state variable" id="_7a712eac-7e0c-4720-8d3f-17e6bc93d395"> <state value="" variable="S873"/> <bbox w="30.0" h="10.0" x="20189.5" y="3789.3218"/> </glyph> <glyph class="state variable" id="_ccd5ea67-41e7-431b-9fbe-afaa52b4bab8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20086.021" y="3766.75"/> </glyph> <glyph class="state variable" id="_76f298d7-398d-46f2-98bf-6a278df1bfe9"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="20025.516" y="3766.75"/> </glyph> <glyph class="state variable" id="_b74c252f-b391-42d6-8e5a-385b41a72c65"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20099.484" y="3766.75"/> </glyph> <glyph class="state variable" id="_70d12eab-2f82-4b7f-bf5e-2a5c96b8e4c7"> <state value="" variable="S868"/> <bbox w="30.0" h="10.0" x="20182.451" y="3766.75"/> </glyph> <glyph class="state variable" id="_98ebe570-c329-4c77-8361-dd34b7dbcaf5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20137.855" y="3811.75"/> </glyph> <glyph class="state variable" id="_f924b57c-1493-418d-b7b5-bf0a081a9b3b"> <state value="" variable="S877"/> <bbox w="30.0" h="10.0" x="20188.225" y="3811.75"/> </glyph> <glyph class="state variable" id="_97b3c494-b90d-47e2-805a-001a3f9a19f0"> <state value="" variable="S880"/> <bbox w="30.0" h="10.0" x="20145.6" y="3811.75"/> </glyph> <glyph class="state variable" id="_146c4c9b-9361-4026-b5d3-8a300d696c6f"> <state value="" variable="S903"/> <bbox w="30.0" h="10.0" x="20108.453" y="3811.75"/> </glyph> <glyph class="state variable" id="_6b9108a7-daef-453c-ba09-8b8fc8617cd5"> <state value="" variable="S910"/> <bbox w="30.0" h="10.0" x="20024.994" y="3811.75"/> </glyph> <glyph class="state variable" id="_021a20ef-cbf3-44fc-b4c8-96dcaa6be3d6"> <state value="" variable="S852"/> <bbox w="30.0" h="10.0" x="20105.416" y="3766.75"/> </glyph> <glyph class="state variable" id="_f904149e-e593-40d0-8459-182df416bca3"> <state value="" variable="S1006"/> <bbox w="35.0" h="10.0" x="20022.0" y="3783.226"/> </glyph> <glyph class="state variable" id="_e22a2c66-5dde-4e8b-a3d6-7fa9fb6572e2"> <state value="" variable="S865"/> <bbox w="30.0" h="10.0" x="20141.957" y="3766.75"/> </glyph> <glyph class="state variable" id="_4bbdfb7e-c177-4e3a-8ec6-c634adea6310"> <state value="" variable="S980"/> <bbox w="30.0" h="10.0" x="20024.5" y="3791.6987"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s274_shh1_shh2_csa30" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BAK1:MIR29B* Identifiers_end References_begin: s_shh2_re134:(MAP:survival) PMID:21245165 References_end</body> </html> </notes> <label text="miR-29b_N-BAK"/> <bbox w="100.0" h="120.0" x="19842.0" y="4322.0"/> <glyph class="nucleic acid feature" id="shh1_shh2_s276_shh1_shh2_sa240"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 29b-1 HUGO:MIR29B1 HGNC:31619 ENTREZ:407024 GENECARDS:MIR29B1 KEGG:407024 ATLASONC:GC_MIR29B1 WIKI:MIR29B1 HUGO:MIR29B*1 HGNC:31619 ENTREZ:407024 GENECARDS:MIR29B*1 WIKI:MIR29B*1 microRNA 29b-2 HUGO:MIR29B2 HGNC:31620 ENTREZ:407025 GENECARDS:MIR29B2 KEGG:407025 ATLASONC:GC_MIR29B2 WIKI:MIR29B2 HUGO:MIR29B*2 HGNC:31620 ENTREZ:407025 GENECARDS:MIR29B*2 WIKI:MIR29B*2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21359530 References_end</body> </html> </notes> <label text="MIR29B*"/> <bbox w="90.0" h="25.0" x="19847.5" y="4337.0"/> <glyph class="unit of information" id="_685d1de7-3247-4623-a557-a5909eb12560"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="19877.5" y="4332.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_shh2_s278_shh1_shh2_sa242"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Bak HUGO:BAK1 HGNC:949 ENTREZ:578 UNIPROT:Q16611 GENECARDS:BAK1 REACTOME:50691 KEGG:578 ATLASONC:BAK1ID752ch6p21 WIKI:BAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21195116 References_end</body> </html> </notes> <label text="BAK1"/> <bbox w="90.0" h="25.0" x="19851.5" y="4366.0"/> <glyph class="unit of information" id="_0efffde1-4e0d-416e-9b24-1ff23a26805d"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="19886.5" y="4361.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s273_shh1_shh2_csa29" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BBC3:MIR29B* Identifiers_end References_begin: s_shh2_re133:(MAP:survival) PMID:21245165 References_end</body> </html> </notes> <label text="miR-29b_PUMA"/> <bbox w="100.0" h="120.0" x="19691.0" y="4322.0"/> <glyph class="nucleic acid feature" id="shh1_shh2_s275_shh1_shh2_sa239"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 29b-1 HUGO:MIR29B1 HGNC:31619 ENTREZ:407024 GENECARDS:MIR29B1 KEGG:407024 ATLASONC:GC_MIR29B1 WIKI:MIR29B1 HUGO:MIR29B*1 HGNC:31619 ENTREZ:407024 GENECARDS:MIR29B*1 WIKI:MIR29B*1 microRNA 29b-2 HUGO:MIR29B2 HGNC:31620 ENTREZ:407025 GENECARDS:MIR29B2 KEGG:407025 ATLASONC:GC_MIR29B2 WIKI:MIR29B2 HUGO:MIR29B*2 HGNC:31620 ENTREZ:407025 GENECARDS:MIR29B*2 WIKI:MIR29B*2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21359530 References_end</body> </html> </notes> <label text="MIR29B*"/> <bbox w="90.0" h="25.0" x="19696.5" y="4335.0"/> <glyph class="unit of information" id="_e76fd439-5ea0-488b-84dc-648cffcba047"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="19726.5" y="4330.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_shh2_s277_shh1_shh2_sa241"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: BCL2 binding component 3 HUGO:BBC3 HGNC:17868 ENTREZ:27113 UNIPROT:Q96PG8 GENECARDS:BBC3 KEGG:27113 ATLASONC:BBC3ID759ch19q13 WIKI:BBC3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19652530 PMID:20673124 References_end Identifiers_begin: BCL2 binding component 3 HUGO:BBC3 HGNC:17868 ENTREZ:27113 UNIPROT:Q96PG8 GENECARDS:BBC3 KEGG:27113 ATLASONC:BBC3ID759ch19q13 WIKI:BBC3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19652530 PMID:20673124 References_end</body> </html> </notes> <label text="BBC3"/> <bbox w="90.0" h="25.0" x="19700.5" y="4363.0"/> <glyph class="unit of information" id="_962788f2-8c8d-49d2-a653-c1d0cee6bc0d"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="19735.5" y="4358.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s296_shh1_shh2_csa33" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL2L11:MIR17-5P* Identifiers_end References_begin: s_shh2_re146:(MAP:survival) PMID18493594 References_end</body> </html> </notes> <label text="miR-17-5p_BIM"/> <bbox w="100.0" h="120.0" x="19688.0" y="4464.0"/> <glyph class="nucleic acid feature" id="shh1_shh2_s297_shh1_shh2_sa258"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 GENECARDS:BCL2L11 REACTOME:401534 KEGG:10018 ATLASONC:BCL2L11ID772ch2q13 WIKI:BCL2L11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19934277 PMID:20673124 References_end Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 GENECARDS:BCL2L11 REACTOME:401534 KEGG:10018 ATLASONC:BCL2L11ID772ch2q13 WIKI:BCL2L11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19934277 PMID:20673124 References_end</body> </html> </notes> <label text="BCL2L11"/> <bbox w="90.0" h="25.0" x="19694.0" y="4507.0"/> <glyph class="unit of information" id="_b445041c-ee85-4870-b904-be46e8d1f51f"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="19729.0" y="4502.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_shh2_s298_shh1_shh2_sa259"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 17 HUGO:MIR17 HGNC:31547 ENTREZ:406952 GENECARDS:MIR17 KEGG:406952 ATLASONC:GC_MIR17 WIKI:MIR17 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20851997 References_end</body> </html> </notes> <label text="MIR17-5P*"/> <bbox w="90.0" h="25.0" x="19694.0" y="4480.0"/> <glyph class="unit of information" id="_63d3fdc8-9ae3-45df-9e63-4414663028d2"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="19724.0" y="4475.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s264_shh1_shh2_csa26" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BCL2L11:MIR29B* Identifiers_end References_begin: s_shh2_re130:(MAP:survival) PMID:21245165 References_end</body> </html> </notes> <label text="miR-29b_BIM"/> <bbox w="100.0" h="120.0" x="19691.0" y="4179.0"/> <glyph class="nucleic acid feature" id="shh1_shh2_s266_shh1_shh2_sa226"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 29b-1 HUGO:MIR29B1 HGNC:31619 ENTREZ:407024 GENECARDS:MIR29B1 KEGG:407024 ATLASONC:GC_MIR29B1 WIKI:MIR29B1 HUGO:MIR29B*1 HGNC:31619 ENTREZ:407024 GENECARDS:MIR29B*1 WIKI:MIR29B*1 microRNA 29b-2 HUGO:MIR29B2 HGNC:31620 ENTREZ:407025 GENECARDS:MIR29B2 KEGG:407025 ATLASONC:GC_MIR29B2 WIKI:MIR29B2 HUGO:MIR29B*2 HGNC:31620 ENTREZ:407025 GENECARDS:MIR29B*2 WIKI:MIR29B*2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21359530 References_end</body> </html> </notes> <label text="MIR29B*"/> <bbox w="90.0" h="25.0" x="19698.0" y="4196.5"/> <glyph class="unit of information" id="_053ba0a3-a4f2-4ac5-94fa-f0874c51b708"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="19728.0" y="4191.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_shh2_s265_shh1_shh2_sa235"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 GENECARDS:BCL2L11 REACTOME:401534 KEGG:10018 ATLASONC:BCL2L11ID772ch2q13 WIKI:BCL2L11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19934277 PMID:20673124 References_end Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 GENECARDS:BCL2L11 REACTOME:401534 KEGG:10018 ATLASONC:BCL2L11ID772ch2q13 WIKI:BCL2L11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19934277 PMID:20673124 References_end</body> </html> </notes> <label text="BCL2L11"/> <bbox w="90.0" h="25.0" x="19698.0" y="4226.0"/> <glyph class="unit of information" id="_56df45d2-18a6-4ffd-9ccc-5e2c02f41f12"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="19733.0" y="4221.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s267_shh1_shh2_csa27" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:BMF:MIR29B* Identifiers_end References_begin: s_shh2_re131:(MAP:survival) PMID:21245165 References_end</body> </html> </notes> <label text="miR-29b_BMF"/> <bbox w="100.0" h="120.0" x="19842.0" y="4179.0"/> <glyph class="nucleic acid feature" id="shh1_shh2_s269_shh1_shh2_sa233"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 29b-1 HUGO:MIR29B1 HGNC:31619 ENTREZ:407024 GENECARDS:MIR29B1 KEGG:407024 ATLASONC:GC_MIR29B1 WIKI:MIR29B1 HUGO:MIR29B*1 HGNC:31619 ENTREZ:407024 GENECARDS:MIR29B*1 WIKI:MIR29B*1 microRNA 29b-2 HUGO:MIR29B2 HGNC:31620 ENTREZ:407025 GENECARDS:MIR29B2 KEGG:407025 ATLASONC:GC_MIR29B2 WIKI:MIR29B2 HUGO:MIR29B*2 HGNC:31620 ENTREZ:407025 GENECARDS:MIR29B*2 WIKI:MIR29B*2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21359530 References_end</body> </html> </notes> <label text="MIR29B*"/> <bbox w="90.0" h="25.0" x="19849.5" y="4192.5"/> <glyph class="unit of information" id="_b9913efb-ae57-4418-a65a-bc43c70ca129"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="19879.5" y="4187.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_shh2_s268_shh1_shh2_sa237"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: BMF HUGO:BMF HGNC:24132 ENTREZ:90427 UNIPROT:Q96LC9 GENECARDS:BMF REACTOME:140208 ATLASONC:GC_BMF WIKI:BMF Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16243507 References_end</body> </html> </notes> <label text="BMF"/> <bbox w="90.0" h="25.0" x="19849.5" y="4222.0"/> <glyph class="unit of information" id="_fe7f321f-682e-4fd9-9536-bc0e38b0e72c"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="19884.5" y="4217.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s210_shh1_shh2_csa22" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK8:Core_promoter*:CyclinC*:MED12:MED13:Mediator* Identifiers_end References_begin: s_shh2_re51(MAP:survival): PMID:9216996 PMID:16413481 PMID:17000779 ANNOTATION: it was shown that Med12 binds to Gli1 promoter References_end</body> </html> </notes> <label text="MEDIATOR_MED_CYCLINC_CDK8"/> <bbox w="283.0" h="244.0" x="19248.5" y="3702.5"/> <glyph class="nucleic acid feature" id="shh1_shh2_s211_shh1_shh2_sa192"> <label text="Core_promoter*"/> <bbox w="70.0" h="25.0" x="19355.5" y="3814.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh2_s212_shh1_shh2_sa193"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21330129 ANNOTATION: Mediator consists of more than 20 subunits and can also excists as an holoenzyme. Therefore Mediator is depicted as one simple protein to reduce complexity. References_end</body> </html> </notes> <label text="Mediator*"/> <bbox w="80.0" h="40.0" x="19259.5" y="3760.5"/> </glyph> <glyph class="macromolecule" id="shh1_shh2_s213_shh1_shh2_sa194"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Cyclin C HUGO:CCNC HGNC:1581 ENTREZ:892 UNIPROT:P24863 GENECARDS:CCNC REACTOME:51936 KEGG:892 ATLASONC:GC_CCNC WIKI:CCNC Identifiers_end Maps_Modules_begin: MAP:cellcycle / MODULE:CYCLINC MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21330129 References_end</body> </html> </notes> <label text="CyclinC*"/> <bbox w="80.0" h="40.0" x="19427.5" y="3760.5"/> </glyph> <glyph class="macromolecule" id="shh1_shh2_s214_shh1_shh2_sa195"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Cyclin-dependent kinase 8 HUGO:CDK8 HGNC:1779 ENTREZ:1024 UNIPROT:P49336 GENECARDS:CDK8 REACTOME:69456 KEGG:1024 ATLASONC:GC_CDK8 WIKI:CDK8 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21327159 PMID:21330129 Cyclin-dependent kinase References_end</body> </html> </notes> <label text="CDK8"/> <bbox w="80.0" h="40.0" x="19427.5" y="3715.5"/> </glyph> <glyph class="macromolecule" id="shh1_shh2_s215_shh1_shh2_sa196"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Mediator complex subunit 12 HUGO:MED12 HGNC:11957 ENTREZ:9968 UNIPROT:Q93074 GENECARDS:MED12 REACTOME:65526 KEGG:9968 ATLASONC:GC_MED12 WIKI:MED12 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17000779 PMID:21330129 Mediator complex subunit References_end</body> </html> </notes> <label text="MED12"/> <bbox w="80.0" h="40.0" x="19343.5" y="3715.5"/> </glyph> <glyph class="macromolecule" id="shh1_shh2_s216_shh1_shh2_sa197"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Mediator complex subunit 13 HUGO:MED13 HGNC:22474 ENTREZ:9969 UNIPROT:Q9UHV7 GENECARDS:MED13 REACTOME:65530 KEGG:9969 WIKI:MED13 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17000779 PMID:21330129 Mediator complex subunit References_end</body> </html> </notes> <label text="MED13"/> <bbox w="80.0" h="40.0" x="19343.5" y="3760.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_shh2_s224_shh1_shh2_sa198"> <label text="promoter_region"/> <bbox w="70.0" h="25.0" x="19435.5" y="3814.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh2_s225_shh1_shh2_sa199"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 3 HUGO:GLI3 HGNC:4319 ENTREZ:2737 UNIPROT:P10071 GENECARDS:GLI3 KEGG:2737 ATLASONC:GC_GLI3 WIKI:GLI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI3-190*"/> <bbox w="165.0" h="41.0" x="19344.75" y="3850.0"/> <glyph class="state variable" id="_82c532e7-b89c-40a6-95e1-4769c1de10c9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19371.76" y="3845.0"/> </glyph> <glyph class="state variable" id="_b4964a8b-2882-4ea1-9fee-b55460df154c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19391.271" y="3845.0"/> </glyph> <glyph class="state variable" id="_a54e6bc0-c6cb-4789-b68b-b8ba9f380d7a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19404.734" y="3845.0"/> </glyph> <glyph class="state variable" id="_fe1dc2ce-e2a1-4adf-aa0d-061b00401e95"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19443.105" y="3886.0"/> </glyph> <glyph class="state variable" id="_d395b754-0530-4dac-8cb5-793069d248b8"> <state value="" variable="S860"/> <bbox w="30.0" h="10.0" x="19429.902" y="3845.0"/> </glyph> <glyph class="state variable" id="_1a7f3a98-44e2-4899-9932-45d4b25e1b87"> <state value="" variable="S907"/> <bbox w="30.0" h="10.0" x="19377.137" y="3886.0"/> </glyph> <glyph class="state variable" id="_435cd86d-2a0a-4922-aac7-695adbab4d2f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19371.76" y="3845.0"/> </glyph> <glyph class="state variable" id="_4d04b622-53e1-4807-90f1-9a187a156d24"> <state value="" variable="S873"/> <bbox w="30.0" h="10.0" x="19494.75" y="3865.5652"/> </glyph> <glyph class="state variable" id="_7277b496-5280-465d-b291-b1839ba8d8ba"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19391.271" y="3845.0"/> </glyph> <glyph class="state variable" id="_10a853a7-be3c-4230-96fd-a615e5f29cb3"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="19330.766" y="3845.0"/> </glyph> <glyph class="state variable" id="_16154ccf-7884-4017-9f5b-35d048db5e41"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19404.734" y="3845.0"/> </glyph> <glyph class="state variable" id="_4fec949a-ad1f-48a8-b872-2812e4d1c124"> <state value="" variable="S868"/> <bbox w="30.0" h="10.0" x="19487.701" y="3845.0"/> </glyph> <glyph class="state variable" id="_6eba9a7a-1a68-471d-b6f9-fe7f657280df"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19443.105" y="3886.0"/> </glyph> <glyph class="state variable" id="_f9ba1b63-1890-46e6-b4fc-92a306db5df2"> <state value="" variable="S877"/> <bbox w="30.0" h="10.0" x="19493.475" y="3886.0"/> </glyph> <glyph class="state variable" id="_3589a33a-8f21-405f-b4fe-63f4558729bd"> <state value="" variable="S880"/> <bbox w="30.0" h="10.0" x="19450.85" y="3886.0"/> </glyph> <glyph class="state variable" id="_85ae7e09-d0e6-4f28-b7cc-664f71542d2d"> <state value="" variable="S903"/> <bbox w="30.0" h="10.0" x="19413.703" y="3886.0"/> </glyph> <glyph class="state variable" id="_79d40e34-1bae-4eff-8a21-b53aa8c6811c"> <state value="" variable="S910"/> <bbox w="30.0" h="10.0" x="19330.244" y="3886.0"/> </glyph> <glyph class="state variable" id="_ce1b6f7c-fe99-48a6-875b-1cd54aa12c90"> <state value="" variable="S852"/> <bbox w="30.0" h="10.0" x="19410.666" y="3845.0"/> </glyph> <glyph class="state variable" id="_31e3f01a-43b2-4bff-ba3f-094213082498"> <state value="" variable="S1006"/> <bbox w="35.0" h="10.0" x="19327.25" y="3860.0115"/> </glyph> <glyph class="state variable" id="_a236b58a-7d3f-4c43-95e8-e3ed589e3779"> <state value="" variable="S865"/> <bbox w="30.0" h="10.0" x="19447.207" y="3845.0"/> </glyph> <glyph class="state variable" id="_db17d251-5863-48cc-8ea3-d54dd8d77896"> <state value="" variable="S980"/> <bbox w="30.0" h="10.0" x="19329.75" y="3867.7312"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh2_s227_shh1_shh2_sa201"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end</body> </html> Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end</body> </html> </notes> <label text="CBP*"/> <bbox w="80.0" h="40.0" x="19254.5" y="3853.0"/> <glyph class="state variable" id="_02d7a2c3-b33c-4116-a5a2-f5600955c91d"> <state value="" variable="S92"/> <bbox w="25.0" h="10.0" x="19242.492" y="3848.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s26_shh1_shh2_csa3" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CRM1*:GLI1 Identifiers_end References_begin: s_shh2_re8:(MAP:survival) PMID:12138125 References_end</body> </html> </notes> <label text="GLI1_CRM1*"/> <bbox w="100.0" h="120.0" x="18327.0" y="3650.0"/> <glyph class="macromolecule" id="shh1_shh2_s27_shh1_shh2_sa23"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 1 HUGO:GLI1 HGNC:4317 ENTREZ:2735 UNIPROT:P08151 GENECARDS:GLI1 KEGG:2735 ATLASONC:GLIID310ch12q13 WIKI:GLI1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI1"/> <bbox w="80.0" h="40.0" x="18337.5" y="3658.0"/> <glyph class="state variable" id="_777eb845-ddce-4ebd-be02-d949c43b2c99"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18332.5" y="3653.0"/> </glyph> <glyph class="state variable" id="_e8bf57bb-a03d-4cb4-81d8-19e79652e73d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18332.5" y="3693.0"/> </glyph> <glyph class="state variable" id="_2590020b-2351-43c5-b110-35b65aace5ad"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18412.5" y="3653.0"/> </glyph> <glyph class="state variable" id="_1adb3767-c984-4700-be1f-68b0434b1b9f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18412.5" y="3693.0"/> </glyph> <glyph class="state variable" id="_f67e5629-2fc6-4535-be65-16c9789dcd07"> <state value="" variable="T374"/> <bbox w="30.0" h="10.0" x="18401.88" y="3693.0"/> </glyph> <glyph class="state variable" id="_6d8b97f4-2419-468f-883f-9555523d0b53"> <state value="" variable="S640"/> <bbox w="30.0" h="10.0" x="18322.5" y="3692.7224"/> </glyph> <glyph class="state variable" id="_ca73e397-51db-4e5b-a283-65d86a9c1675"> <state value="" variable="K518"/> <bbox w="30.0" h="10.0" x="18345.475" y="3693.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh2_s28_shh1_shh2_sa24"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> </notes> <label text="CRM1*"/> <bbox w="80.0" h="40.0" x="18337.5" y="3702.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s29_shh1_shh2_csa4" compartmentRef="shh1_shh2_c3_shh1_shh2_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CRM1*:GLI1 Identifiers_end References_begin: s_shh2_re9:(MAP:survival) PMID:12138125 References_end</body> </html> </notes> <label text="GLI1_CRM1*"/> <bbox w="100.0" h="120.0" x="18040.5" y="3650.0"/> <glyph class="macromolecule" id="shh1_shh2_s30_shh1_shh2_sa25"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 1 HUGO:GLI1 HGNC:4317 ENTREZ:2735 UNIPROT:P08151 GENECARDS:GLI1 KEGG:2735 ATLASONC:GLIID310ch12q13 WIKI:GLI1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI1"/> <bbox w="80.0" h="40.0" x="18051.0" y="3658.0"/> <glyph class="state variable" id="_16197742-ce5b-4831-845b-79bfd87a8a79"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18046.0" y="3653.0"/> </glyph> <glyph class="state variable" id="_ef255b5b-1d97-4910-918a-a2cdcdc46675"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18046.0" y="3693.0"/> </glyph> <glyph class="state variable" id="_bec5cda9-c8f1-4e04-a959-1b052f8e3839"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18126.0" y="3653.0"/> </glyph> <glyph class="state variable" id="_fc4c3ceb-dced-489b-8271-ebf3a281ea71"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18126.0" y="3693.0"/> </glyph> <glyph class="state variable" id="_81224968-6a04-4685-8a46-2fc22e629e8b"> <state value="" variable="T374"/> <bbox w="30.0" h="10.0" x="18115.38" y="3693.0"/> </glyph> <glyph class="state variable" id="_d8318128-18b7-402e-a39f-29ca7f1b4f05"> <state value="" variable="S640"/> <bbox w="30.0" h="10.0" x="18036.0" y="3692.7224"/> </glyph> <glyph class="state variable" id="_728918b5-c862-4769-860d-92ccf20eec0a"> <state value="" variable="K518"/> <bbox w="30.0" h="10.0" x="18058.975" y="3693.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh2_s31_shh1_shh2_sa26"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> </notes> <label text="CRM1*"/> <bbox w="80.0" h="40.0" x="18051.0" y="3702.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s233_shh1_shh2_csa23" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CUL3:KCASH2* Identifiers_end</body> </html> </notes> <label text="CUL3_KCASH2"/> <bbox w="100.0" h="120.0" x="18225.0" y="4062.0"/> <glyph class="macromolecule" id="shh1_shh2_s238_shh1_shh2_sa206"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Cullin 3 HUGO:CUL3 HGNC:2553 ENTREZ:8452 UNIPROT:Q13618 GENECARDS:CUL3 REACTOME:53166 KEGG:8452 ATLASONC:GC_CUL3 WIKI:CUL3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17312394 PMID:15688063 References_end Identifiers_begin: Cullin 3 HUGO:CUL3 HGNC:2553 ENTREZ:8452 UNIPROT:Q13618 GENECARDS:CUL3 REACTOME:53166 KEGG:8452 ATLASONC:GC_CUL3 WIKI:CUL3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17312394 PMID:15688063 References_end</body> </html> </notes> <label text="CUL3"/> <bbox w="80.0" h="40.0" x="18234.0" y="4070.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh2_s236_shh1_shh2_sa208"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: KCASH2 HUGO:KCTD21 HGNC:27452 ENTREZ:283219 UNIPROT:Q4G0X4 GENECARDS:KCTD21 KEGG:283219 ATLASONC:GC_KCTD21 WIKI:KCTD21 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21472142 Potassium channel tetramerisation domain containing 21 References_end</body> </html> </notes> <label text="KCASH2*"/> <bbox w="80.0" h="40.0" x="18234.0" y="4113.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s239_shh1_shh2_csa24" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CUL3:KCASH3* Identifiers_end</body> </html> </notes> <label text="CUL3_KCASH3"/> <bbox w="100.0" h="120.0" x="18330.5" y="4062.0"/> <glyph class="macromolecule" id="shh1_shh2_s234_shh1_shh2_sa207"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Cullin 3 HUGO:CUL3 HGNC:2553 ENTREZ:8452 UNIPROT:Q13618 GENECARDS:CUL3 REACTOME:53166 KEGG:8452 ATLASONC:GC_CUL3 WIKI:CUL3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17312394 PMID:15688063 References_end Identifiers_begin: Cullin 3 HUGO:CUL3 HGNC:2553 ENTREZ:8452 UNIPROT:Q13618 GENECARDS:CUL3 REACTOME:53166 KEGG:8452 ATLASONC:GC_CUL3 WIKI:CUL3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17312394 PMID:15688063 References_end</body> </html> </notes> <label text="CUL3"/> <bbox w="80.0" h="40.0" x="18339.5" y="4075.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh2_s237_shh1_shh2_sa209"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: KCASH3 HUGO:KCTD6 HGNC:22235 ENTREZ:200845 UNIPROT:Q8NC69 GENECARDS:KCTD6 KEGG:200845 ATLASONC:GC_KCTD6 WIKI:KCTD6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21472142 Potassium channel tetramerisation domain containing 6 References_end</body> </html> </notes> <label text="KCASH3*"/> <bbox w="80.0" h="40.0" x="18339.5" y="4117.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s119_shh1_shh2_csa11" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CUL3:REN* Identifiers_end</body> </html> </notes> <label text="CUL3_REN"/> <bbox w="100.0" h="120.0" x="18436.0" y="4062.0"/> <glyph class="macromolecule" id="shh1_shh2_s120_shh1_shh2_sa109"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Cullin 3 HUGO:CUL3 HGNC:2553 ENTREZ:8452 UNIPROT:Q13618 GENECARDS:CUL3 REACTOME:53166 KEGG:8452 ATLASONC:GC_CUL3 WIKI:CUL3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17312394 PMID:15688063 References_end Identifiers_begin: Cullin 3 HUGO:CUL3 HGNC:2553 ENTREZ:8452 UNIPROT:Q13618 GENECARDS:CUL3 REACTOME:53166 KEGG:8452 ATLASONC:GC_CUL3 WIKI:CUL3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17312394 PMID:15688063 References_end</body> </html> </notes> <label text="CUL3"/> <bbox w="80.0" h="40.0" x="18444.5" y="4073.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh2_s121_shh1_shh2_sa110"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Potassium channel tetramerisation domain 11 HUGO:KCTD11 HGNC:21302 ENTREZ:147040 UNIPROT:Q693B1 GENECARDS:KCTD11 KEGG:147040 ATLASONC:GC_KCTD11 WIKI:KCTD11 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:15467454 References_end</body> </html> </notes> <label text="REN*"/> <bbox w="80.0" h="40.0" x="18444.5" y="4117.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s5_shh1_shh2_csa1" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CUL3:Spop Identifiers_end References_begin: s_shh2_re1:(MAP:survival) PMID:20360384 PMID:16740475 s_shh2_re115:(MAP:survival) PMID:20463034 References_end</body> </html> </notes> <label text="SPOP_CUL3_E3_ligase"/> <bbox w="100.0" h="120.0" x="19733.5" y="3316.0"/> <glyph class="macromolecule" id="shh1_shh2_s3_shh1_shh2_sa4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Speckle-type POZ protein HUGO:SPOP HGNC:11254 ENTREZ:8405 UNIPROT:O43791 GENECARDS:SPOP KEGG:8405 ATLASONC:GC_SPOP WIKI:SPOP Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19818708 References_end</body> </html> </notes> <label text="Spop"/> <bbox w="80.0" h="40.0" x="19743.0" y="3327.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh2_s4_shh1_shh2_sa5"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Cullin 3 HUGO:CUL3 HGNC:2553 ENTREZ:8452 UNIPROT:Q13618 GENECARDS:CUL3 REACTOME:53166 KEGG:8452 ATLASONC:GC_CUL3 WIKI:CUL3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17312394 PMID:15688063 References_end Identifiers_begin: Cullin 3 HUGO:CUL3 HGNC:2553 ENTREZ:8452 UNIPROT:Q13618 GENECARDS:CUL3 REACTOME:53166 KEGG:8452 ATLASONC:GC_CUL3 WIKI:CUL3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17312394 PMID:15688063 References_end</body> </html> </notes> <label text="CUL3"/> <bbox w="80.0" h="40.0" x="19743.0" y="3370.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s312_shh1_shh2_csa37" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CyclinD*:MIR17-5P* Identifiers_end References_begin: s_shh2_re154:(MAP:survival) PMID:18695042 References_end</body> </html> </notes> <label text="miR-17-5p_CYCLIND"/> <bbox w="100.0" h="120.0" x="19840.0" y="4616.0"/> <glyph class="nucleic acid feature" id="shh1_shh2_s314_shh1_shh2_sa269"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 PMID:20673124 References_end Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 PMID:20673124 References_end</body> </html> Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 PMID:20673124 References_end</body> </html> </notes> <label text="CyclinD*"/> <bbox w="90.0" h="25.0" x="19844.5" y="4654.0"/> <glyph class="unit of information" id="_b32ec902-a8ac-46b3-a879-11b450522d63"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="19879.5" y="4649.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_shh2_s315_shh1_shh2_sa270"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 17 HUGO:MIR17 HGNC:31547 ENTREZ:406952 GENECARDS:MIR17 KEGG:406952 ATLASONC:GC_MIR17 WIKI:MIR17 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20851997 References_end</body> </html> </notes> <label text="MIR17-5P*"/> <bbox w="90.0" h="25.0" x="19844.5" y="4627.0"/> <glyph class="unit of information" id="_d06224cd-dc3b-420b-9dba-5317c7d662ec"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="19874.5" y="4622.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s313_shh1_shh2_csa38" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CyclinD*:MIR20A Identifiers_end References_begin: s_shh2_re155:(MAP:survival) PMID:18695042 References_end</body> </html> </notes> <label text="miR-20a_CYCLIND"/> <bbox w="100.0" h="120.0" x="19984.0" y="4616.0"/> <glyph class="nucleic acid feature" id="shh1_shh2_s317_shh1_shh2_sa271"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 20a HUGO:MIR20A HGNC:31577 ENTREZ:406982 GENECARDS:MIR20A KEGG:406982 ATLASONC:GC_MIR20A WIKI:MIR20A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20851997 References_end</body> </html> </notes> <label text="MIR20A"/> <bbox w="90.0" h="25.0" x="19992.0" y="4620.0"/> <glyph class="unit of information" id="_6ac07a79-3886-4369-bbdc-008fc081f762"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="20022.0" y="4615.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_shh2_s316_shh1_shh2_sa272"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 PMID:20673124 References_end Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 PMID:20673124 References_end</body> </html> Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 PMID:20673124 References_end</body> </html> </notes> <label text="CyclinD*"/> <bbox w="90.0" h="25.0" x="19989.0" y="4646.0"/> <glyph class="unit of information" id="_e71c974e-d1d6-4e60-9120-b1c9fe5cd642"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="20024.0" y="4641.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s295_shh1_shh2_csa32" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:E2F1:MIR17-3P* Identifiers_end References_begin: s_shh2_re144:(MAP:survival) PMID:15944709 References_end</body> </html> </notes> <label text="miR-17-5p_E2F1"/> <bbox w="100.0" h="120.0" x="19984.0" y="4322.0"/> <glyph class="nucleic acid feature" id="shh1_shh2_s294_shh1_shh2_sa255"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 17 HUGO:MIR17 HGNC:31547 ENTREZ:406952 GENECARDS:MIR17 KEGG:406952 ATLASONC:GC_MIR17 WIKI:MIR17 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20851997 References_end</body> </html> </notes> <label text="MIR17-3P*"/> <bbox w="90.0" h="25.0" x="19992.0" y="4338.0"/> <glyph class="unit of information" id="_b7fef729-e997-4145-85eb-70a397af1b34"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="20022.0" y="4333.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_shh2_s293_shh1_shh2_sa256"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: E2F transcription factor 1 HUGO:E2F1 HGNC:3113 ENTREZ:1869 UNIPROT:Q01094 GENECARDS:E2F1 REACTOME:89561 KEGG:1869 ATLASONC:E2F1ID40382ch20q11 WIKI:E2F1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17218262 References_end</body> </html> </notes> <label text="E2F1"/> <bbox w="90.0" h="25.0" x="19992.0" y="4366.0"/> <glyph class="unit of information" id="_a013ca49-f735-483c-8868-1cbf20568d1a"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="20027.0" y="4361.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s323_shh1_shh2_csa40" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:ER_alpha_*:MIR18A Identifiers_end References_begin: s_shh2_re157:(MAP:survival) PMID:19684618 References_end</body> </html> </notes> <label text="miR-18a_ER"/> <bbox w="100.0" h="120.0" x="20119.0" y="4179.0"/> <glyph class="nucleic acid feature" id="shh1_shh2_s324_shh1_shh2_sa278"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: estrogen receptor 1 HUGO:ESR1 HGNC:3467 ENTREZ:2099 UNIPROT:P03372 GENECARDS:ESR1 REACTOME:69672 KEGG:2099 ATLASONC:GC_ESR1 WIKI:ESR1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21267694 References_end</body> </html> </notes> <label text="ERα*"/> <bbox w="90.0" h="25.0" x="20123.5" y="4220.0"/> <glyph class="unit of information" id="_b7ef6633-0bd3-4565-8ea1-a829c81f3bdd"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="20158.5" y="4215.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_shh2_s325_shh1_shh2_sa279"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 18a HUGO:MIR18A HGNC:31548 ENTREZ:406953 GENECARDS:MIR18A KEGG:406953 ATLASONC:GC_MIR18A WIKI:MIR18A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20851997 References_end</body> </html> </notes> <label text="MIR18A"/> <bbox w="90.0" h="25.0" x="20123.5" y="4193.0"/> <glyph class="unit of information" id="_deaaed01-afc0-4a21-8060-8220a6de5299"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="20153.5" y="4188.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s205_shh1_shh2_csa20" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FUS:MIR378 Identifiers_end References_begin: s_shh2_re159:(MAP:survival) PMID:18077375 References_end</body> </html> </notes> <label text="miR-378_Fus-1"/> <bbox w="100.0" h="120.0" x="19984.0" y="4036.0"/> <glyph class="nucleic acid feature" id="shh1_shh2_s207_shh1_shh2_sa183"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 378 HUGO:MIR378 GENECARDS:MIR378 KEGG:494327 WIKI:MIR378 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19446450 PMID:18077375 References_end</body> </html> </notes> <label text="MIR378"/> <bbox w="90.0" h="25.0" x="19990.75" y="4053.0"/> <glyph class="unit of information" id="_4a0a9994-97c3-42a8-a16d-d1e302e23601"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="20020.75" y="4048.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_shh2_s206_shh1_shh2_sa184"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: FUS1 HUGO:FUS HGNC:4010 ENTREZ:2521 UNIPROT:P35637 GENECARDS:FUS REACTOME:55036 KEGG:2521 ATLASONC:FUSID44 WIKI:FUS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17533367 References_end</body> </html> </notes> <label text="FUS"/> <bbox w="90.0" h="25.0" x="19990.75" y="4086.0"/> <glyph class="unit of information" id="_cd701a05-80c8-444c-8260-79fafb01d8b6"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="20025.75" y="4081.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s328_shh1_shh2_csa41" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:FUS:MIR378 Identifiers_end</body> </html> </notes> <label text="miR-378_FUS1"/> <bbox w="100.0" h="120.0" x="20121.0" y="4322.0"/> <glyph class="nucleic acid feature" id="shh1_shh2_s330_shh1_shh2_sa282"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: FUS1 HUGO:FUS HGNC:4010 ENTREZ:2521 UNIPROT:P35637 GENECARDS:FUS REACTOME:55036 KEGG:2521 ATLASONC:FUSID44 WIKI:FUS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17533367 References_end</body> </html> </notes> <label text="FUS"/> <bbox w="90.0" h="25.0" x="20126.0" y="4367.0"/> <glyph class="unit of information" id="_4b3f3b9d-60fc-4208-b804-f72f5bf6ed0d"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="20161.0" y="4362.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_shh2_s329_shh1_shh2_sa283"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 378 HUGO:MIR378 GENECARDS:MIR378 KEGG:494327 WIKI:MIR378 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19446450 PMID:18077375 References_end</body> </html> </notes> <label text="MIR378"/> <bbox w="90.0" h="25.0" x="20126.0" y="4340.0"/> <glyph class="unit of information" id="_7bb44e91-101b-48b6-8c7b-b5cc015bf65f"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="20156.0" y="4335.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s135_shh1_shh2_csa12" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GLI1:MSIN3*:SAP18:SUFU:promoter_region Identifiers_end References_begin: s_shh2_re81:(MAP:survival) PMID:11960000 References_end</body> </html> </notes> <label text="GLI1_gene_SUFU_SAP18_MSIN3"/> <bbox w="103.0" h="231.0" x="18422.5" y="4529.0"/> <glyph class="nucleic acid feature" id="shh1_shh2_s136_shh1_shh2_sa123"> <label text="promoter_region"/> <bbox w="70.0" h="25.0" x="18438.0" y="4586.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh2_s137_shh1_shh2_sa124"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 1 HUGO:GLI1 HGNC:4317 ENTREZ:2735 UNIPROT:P08151 GENECARDS:GLI1 KEGG:2735 ATLASONC:GLIID310ch12q13 WIKI:GLI1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI1"/> <bbox w="80.0" h="40.0" x="18433.0" y="4540.0"/> <glyph class="state variable" id="_36e8bde1-3736-45d7-857d-a44a43e6d986"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="18425.5" y="4535.0"/> </glyph> <glyph class="state variable" id="_d3f43776-8e75-47d8-bcd1-b1042b163f28"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18428.0" y="4575.0"/> </glyph> <glyph class="state variable" id="_c83dfc09-fdbc-4acd-9d37-bf9ac3ccac13"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="18505.5" y="4535.0"/> </glyph> <glyph class="state variable" id="_1c35277b-91eb-4fd5-b273-72cdc537cc04"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18508.0" y="4575.0"/> </glyph> <glyph class="state variable" id="_aa97d388-b6d0-470a-93f2-a4c2c96683d6"> <state value="" variable="T374"/> <bbox w="30.0" h="10.0" x="18497.38" y="4575.0"/> </glyph> <glyph class="state variable" id="_7bed53c5-b9f0-48ba-857a-e5530ffcd275"> <state value="" variable="S640"/> <bbox w="30.0" h="10.0" x="18418.0" y="4574.722"/> </glyph> <glyph class="state variable" id="_5ef2f85c-9d7a-41e2-a698-1d01a835d75f"> <state value="" variable="K518"/> <bbox w="30.0" h="10.0" x="18440.975" y="4575.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh2_s139_shh1_shh2_sa125"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <bbox w="80.0" h="40.0" x="18433.5" y="4612.5"/> <glyph class="state variable" id="_b4ff77ee-25d9-44d8-8601-d34e7aeced0d"> <state value="" variable="K257"/> <bbox w="30.0" h="10.0" x="18418.992" y="4607.5"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh2_s138_shh1_shh2_sa126"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Sin3A-associated protein 18 kDa HUGO:SAP18 HGNC:10530 ENTREZ:10284 UNIPROT:O00422 GENECARDS:SAP18 KEGG:10284 ATLASONC:GC_SAP18 WIKI:SAP18 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11960000 References_end</body> </html> </notes> <label text="SAP18"/> <bbox w="80.0" h="40.0" x="18433.25" y="4653.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh2_s140_shh1_shh2_sa127"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Sin3 homologue A transcription regulator HUGO:SIN3A HGNC:19353 ENTREZ:25942 UNIPROT:Q96ST3 GENECARDS:SIN3A REACTOME:101853 ATLASONC:GC_SIN3A WIKI:SIN3A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11960000 References_end</body> </html> </notes> <label text="MSIN3*"/> <bbox w="80.0" h="40.0" x="18433.25" y="4693.5"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s43_shh1_shh2_csa6" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GLI2-185*:promoter_region Identifiers_end References_begin: s_shh2_re19:(MAP:survival) PMID:19049965 s_shh2_re20(MAP:survival): PMID:19049965 PMID:11493558 s_shh2_re22:(MAP:survival) PMID:18813803 PMID:16880536 PMID:19190345 s_shh2_re36:(MAP:survival) PMID:16880536 PMID:18813803 PMID:19190345 s_shh2_re38:(MAP:survival) PMID:15140221 PMID:18813803 PMID:18698484 s_shh2_re40:(MAP:survival) PMID:20712011 s_shh2_re42:(MAP:survival) PMID:16396903 PMID:20107231 PMID:16054035 PMID:16406505 PMID:16880536 PMID:17000779 s_shh2_re43:(MAP:survival) PMID:9609833 PMID:16413481 s_shh2_re45:(MAP:survival) PMID:15087129 s_shh2_re49:(MAP:survival) PMID:20143239 PMID:16413481 s_shh2_re51(MAP:survival): PMID:9216996 PMID:16413481 PMID:17000779 ANNOTATION: it was shown that Med12 binds to Gli1 promoter s_shh2_re58:(MAP:survival) PMID:15520176 PMID:14555646 s_shh2_re73:(MAP:survival) PMID:16571352 References_end</body> </html> </notes> <label text="GLI2-185_gene"/> <bbox w="199.0" h="117.0" x="19381.0" y="3340.0"/> <glyph class="macromolecule" id="shh1_shh2_s98_shh1_shh2_sa38"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 2 HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Glioma-associated oncogene family zinc finger PMID:18497536 PMID:17845852 PMID:11001584 References_end</body> </html> </notes> <label text="GLI2-185*"/> <bbox w="165.0" h="45.0" x="19394.75" y="3351.0"/> <glyph class="state variable" id="_fad17fdf-cd03-420d-a374-cbb2d6b9c9e5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19444.982" y="3346.0"/> </glyph> <glyph class="state variable" id="_5b3224a7-d0c4-4353-ae2b-67a9da236d71"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="19483.979" y="3346.0"/> </glyph> <glyph class="state variable" id="_a7f53489-febf-42ad-a4e1-4a00ab4d62dd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19493.105" y="3391.0"/> </glyph> <glyph class="state variable" id="_116b6367-ad56-489c-8b6f-e1282b361e23"> <state value="" variable="S801"/> <bbox w="30.0" h="10.0" x="19448.156" y="3346.0"/> </glyph> <glyph class="state variable" id="_bdbe907a-18ff-48f4-86da-637806257202"> <state value="" variable="K757"/> <bbox w="30.0" h="10.0" x="19379.75" y="3359.99"/> </glyph> <glyph class="state variable" id="_b7b31355-d921-4471-9f26-2b81409d61d7"> <state value="" variable="S956"/> <bbox w="30.0" h="10.0" x="19379.75" y="3390.6875"/> </glyph> <glyph class="state variable" id="_f51aeb50-efa9-434b-841e-59c98a84791e"> <state value="" variable="S817"/> <bbox w="30.0" h="10.0" x="19543.475" y="3391.0"/> </glyph> <glyph class="state variable" id="_f36d3cc2-b2d4-4dfa-84e2-da9a60cc79b1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19472.25" y="3346.0"/> </glyph> <glyph class="state variable" id="_3c08f617-cf47-43af-b9a9-44c934741b3c"> <state value="" variable="S847"/> <bbox w="30.0" h="10.0" x="19430.97" y="3391.0"/> </glyph> <glyph class="state variable" id="_27f07300-e2bc-496f-9901-4fedb254eac8"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="19379.75" y="3368.464"/> </glyph> <glyph class="state variable" id="_d04553b0-efff-4751-9a63-6ccdc35ab54d"> <state value="" variable="S789"/> <bbox w="30.0" h="10.0" x="19379.75" y="3359.4717"/> </glyph> <glyph class="state variable" id="_aa1acac7-162e-475f-8acb-d02b8ff553ea"> <state value="" variable="S1011"/> <bbox w="35.0" h="10.0" x="19377.25" y="3376.4187"/> </glyph> <glyph class="state variable" id="_8d214c53-46ce-4282-b936-b9511ec398a0"> <state value="" variable="S805"/> <bbox w="30.0" h="10.0" x="19483.385" y="3346.0"/> </glyph> <glyph class="state variable" id="_3eb88844-7859-418d-87a6-c0b1ed22fd5c"> <state value="" variable="S820"/> <bbox w="30.0" h="10.0" x="19508.139" y="3391.0"/> </glyph> <glyph class="state variable" id="_5a87760c-0ada-4c1f-9df6-e42b77562b6f"> <state value="" variable="S813"/> <bbox w="30.0" h="10.0" x="19544.75" y="3368.5718"/> </glyph> <glyph class="state variable" id="_535a555b-81a4-4215-abfa-dfbc7896fc64"> <state value="" variable="S850"/> <bbox w="30.0" h="10.0" x="19379.75" y="3389.8171"/> </glyph> <glyph class="state variable" id="_7d0abe2f-a483-46bb-83cf-bc27a6bc0d3e"> <state value="" variable="S844"/> <bbox w="30.0" h="10.0" x="19457.096" y="3391.0"/> </glyph> <glyph class="state variable" id="_3037c756-5ea6-4a1b-9a17-66fcdbdaea21"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="19380.766" y="3346.0"/> </glyph> <glyph class="state variable" id="_0c69314f-e8f3-4f7a-818c-0d88312c53fa"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19493.105" y="3391.0"/> </glyph> <glyph class="state variable" id="_b8354e87-d84d-4415-86b9-5e350fa276b6"> <state value="" variable="S808"/> <bbox w="30.0" h="10.0" x="19543.994" y="3346.0"/> </glyph> <glyph class="state variable" id="_36a03d23-b35e-4708-a1f5-de96cdeafa1a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19433.49" y="3346.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_shh2_s45_shh1_shh2_sa39"> <label text="promoter_region"/> <bbox w="70.0" h="25.0" x="19453.5" y="3408.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s78_shh1_shh2_csa7" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GLI3-190*:promoter_region Identifiers_end References_begin: s_shh2_re42:(MAP:survival) PMID:16396903 PMID:20107231 PMID:16054035 PMID:16406505 PMID:16880536 PMID:17000779 References_end</body> </html> </notes> <label text="GLI3-190_gene"/> <bbox w="199.0" h="113.0" x="19551.0" y="3489.0"/> <glyph class="macromolecule" id="shh1_shh2_s79_shh1_shh2_sa73"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 3 HUGO:GLI3 HGNC:4319 ENTREZ:2737 UNIPROT:P10071 GENECARDS:GLI3 KEGG:2737 ATLASONC:GC_GLI3 WIKI:GLI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI3-190*"/> <bbox w="165.0" h="41.0" x="19565.75" y="3500.0"/> <glyph class="state variable" id="_238c85b8-52b3-4ccd-94b0-35ca5d2d6f49"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19592.76" y="3495.0"/> </glyph> <glyph class="state variable" id="_c9dde609-ac1a-47aa-ac43-d96ce3b6a4c7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19612.271" y="3495.0"/> </glyph> <glyph class="state variable" id="_275032b1-bb61-46f7-ad24-8f5294be8f3b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19625.734" y="3495.0"/> </glyph> <glyph class="state variable" id="_f65580d6-298d-46a3-bf42-8eac23ed810b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19664.105" y="3536.0"/> </glyph> <glyph class="state variable" id="_c0853705-8260-46aa-908d-e1bcee16cf3f"> <state value="" variable="S860"/> <bbox w="30.0" h="10.0" x="19650.902" y="3495.0"/> </glyph> <glyph class="state variable" id="_1132de6f-510b-4030-80e6-b98df15e3dc3"> <state value="" variable="S907"/> <bbox w="30.0" h="10.0" x="19598.137" y="3536.0"/> </glyph> <glyph class="state variable" id="_4fca6fdc-36a4-4ba6-ad00-35d89344e052"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19592.76" y="3495.0"/> </glyph> <glyph class="state variable" id="_280d6f32-a87b-4f40-a902-97e418e1e906"> <state value="" variable="S873"/> <bbox w="30.0" h="10.0" x="19715.75" y="3515.5652"/> </glyph> <glyph class="state variable" id="_6f82e75c-1551-4a7a-9d9c-996c7b7b68b5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19612.271" y="3495.0"/> </glyph> <glyph class="state variable" id="_b1400466-e5cb-486d-86b1-c060b4764005"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="19551.766" y="3495.0"/> </glyph> <glyph class="state variable" id="_aa763ef5-21d0-4274-bcbb-61a5de1af1f0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19625.734" y="3495.0"/> </glyph> <glyph class="state variable" id="_f3069db0-7c1b-42ee-bb2c-858d2bcebb2c"> <state value="" variable="S868"/> <bbox w="30.0" h="10.0" x="19708.701" y="3495.0"/> </glyph> <glyph class="state variable" id="_0bd68b69-a9f3-4bae-8617-a8cea68c01f9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19664.105" y="3536.0"/> </glyph> <glyph class="state variable" id="_dded6875-19a1-4fab-b441-3265d495c13d"> <state value="" variable="S877"/> <bbox w="30.0" h="10.0" x="19714.475" y="3536.0"/> </glyph> <glyph class="state variable" id="_3ed286b3-e320-43bc-983a-d34e887c57bf"> <state value="" variable="S880"/> <bbox w="30.0" h="10.0" x="19671.85" y="3536.0"/> </glyph> <glyph class="state variable" id="_54910192-d966-4731-b3be-a232526916b2"> <state value="" variable="S903"/> <bbox w="30.0" h="10.0" x="19634.703" y="3536.0"/> </glyph> <glyph class="state variable" id="_e0a51b57-93da-4533-866b-c6f765a6277f"> <state value="" variable="S910"/> <bbox w="30.0" h="10.0" x="19551.244" y="3536.0"/> </glyph> <glyph class="state variable" id="_8e979c1e-49e5-4b02-99d5-1cb0e23053ae"> <state value="" variable="S852"/> <bbox w="30.0" h="10.0" x="19631.666" y="3495.0"/> </glyph> <glyph class="state variable" id="_9a465278-6c41-488a-8933-59adca0cffdc"> <state value="" variable="S1006"/> <bbox w="35.0" h="10.0" x="19548.25" y="3510.0115"/> </glyph> <glyph class="state variable" id="_e23d4894-f1cc-4e0e-a5e8-168f70cd7efc"> <state value="" variable="S865"/> <bbox w="30.0" h="10.0" x="19668.207" y="3495.0"/> </glyph> <glyph class="state variable" id="_2f7a1291-a259-4b3e-b1b3-71a2ea7e01d1"> <state value="" variable="S980"/> <bbox w="30.0" h="10.0" x="19550.75" y="3517.7312"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_shh2_s80_shh1_shh2_sa74"> <label text="promoter_region"/> <bbox w="70.0" h="25.0" x="19614.5" y="3551.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s195_shh1_shh2_csa18" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GLI3-83_sub_TRUNC_endsub_*:_beta_-Catenin* Identifiers_end</body> </html> </notes> <label text="GLI3-83 _beta-catenin"/> <bbox w="100.0" h="120.0" x="19005.0" y="4420.0"/> <glyph class="macromolecule" id="shh1_shh2_s196_shh1_shh2_sa175"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="19015.5" y="4433.0"/> <glyph class="state variable" id="_1ad7da83-2cc1-4880-b784-329e30200f29"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="19042.904" y="4468.0"/> </glyph> <glyph class="state variable" id="_9cd277b0-6236-4993-a954-c8ac75a9d7aa"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="19082.38" y="4468.0"/> </glyph> <glyph class="state variable" id="_5eee4a24-ca3e-4288-a99d-ae9c80af615b"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="19083.0" y="4428.215"/> </glyph> <glyph class="state variable" id="_410b1cc9-a215-4b04-bba8-4094e3ccee45"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="19043.031" y="4428.0"/> </glyph> <glyph class="state variable" id="_96d29a7c-9ea6-4195-b647-1b8c7761acd7"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="19003.492" y="4428.0"/> </glyph> <glyph class="state variable" id="_46e20491-ee49-432c-9765-1a6abc8c15b5"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="19003.0" y="4467.722"/> </glyph> <glyph class="state variable" id="_7e2da388-ddc3-4872-80e0-962c0057ca5c"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="19080.5" y="4428.215"/> </glyph> <glyph class="state variable" id="_337b1517-62ea-4d9a-b4da-2c85316cbcc3"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="19080.5" y="4428.215"/> </glyph> <glyph class="state variable" id="_dbaf5c61-c0f8-4c06-81eb-598ce488f6da"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19010.5" y="4448.0"/> </glyph> <glyph class="state variable" id="_38e66826-095d-4b9c-99db-717106ef1e4b"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="19000.992" y="4428.0"/> </glyph> <glyph class="state variable" id="_1a003e1f-3ac7-45cb-bb12-1512b190fa1a"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="19080.5" y="4428.215"/> </glyph> <glyph class="state variable" id="_edd15186-194e-4d3f-8a45-43ce6ac5a187"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19010.5" y="4439.716"/> </glyph> <glyph class="state variable" id="_0dfd0aec-9b5c-472c-8c2f-9e642bc0fe0d"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="19080.5" y="4428.215"/> </glyph> <glyph class="state variable" id="_bbeb402a-b243-4d00-9f0f-f81aee17fb1c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19010.5" y="4448.0"/> </glyph> <glyph class="state variable" id="_7d5a67ac-446b-47f7-8754-69612259984f"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="19079.88" y="4468.0"/> </glyph> <glyph class="state variable" id="_2e918807-4559-4881-9302-486a2125c496"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="19080.5" y="4428.215"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh2_s197_shh1_shh2_sa176"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 3 HUGO:GLI3 HGNC:4319 ENTREZ:2737 UNIPROT:P10071 GENECARDS:GLI3 KEGG:2737 ATLASONC:GC_GLI3 WIKI:GLI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI3-83TRUNC*"/> <bbox w="80.0" h="40.0" x="19015.5" y="4476.0"/> <glyph class="unit of information" id="_be4deba1-68a2-4f7b-977c-01ed54be7c8c"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="19030.5" y="4471.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s270_shh1_shh2_csa28" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HRK:MIR29B* Identifiers_end References_begin: s_shh2_re132:(MAP:survival) PMID:21245165 References_end</body> </html> </notes> <label text="miR-29b_HRK"/> <bbox w="100.0" h="120.0" x="19984.0" y="4179.0"/> <glyph class="nucleic acid feature" id="shh1_shh2_s272_shh1_shh2_sa234"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 29b-1 HUGO:MIR29B1 HGNC:31619 ENTREZ:407024 GENECARDS:MIR29B1 KEGG:407024 ATLASONC:GC_MIR29B1 WIKI:MIR29B1 HUGO:MIR29B*1 HGNC:31619 ENTREZ:407024 GENECARDS:MIR29B*1 WIKI:MIR29B*1 microRNA 29b-2 HUGO:MIR29B2 HGNC:31620 ENTREZ:407025 GENECARDS:MIR29B2 KEGG:407025 ATLASONC:GC_MIR29B2 WIKI:MIR29B2 HUGO:MIR29B*2 HGNC:31620 ENTREZ:407025 GENECARDS:MIR29B*2 WIKI:MIR29B*2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21359530 References_end</body> </html> </notes> <label text="MIR29B*"/> <bbox w="90.0" h="25.0" x="19991.0" y="4193.5"/> <glyph class="unit of information" id="_103087fa-8732-4332-b101-af54a14e18e6"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="20021.0" y="4188.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_shh2_s271_shh1_shh2_sa238"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Harakiri Bcl2-interacting protein HUGO:HRK HGNC:5185 ENTREZ:8739 UNIPROT:O00198 GENECARDS:HRK KEGG:8739 ATLASONC:HRKID40865ch12q24 WIKI:HRK Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19641496 References_end</body> </html> </notes> <label text="HRK"/> <bbox w="90.0" h="25.0" x="19991.0" y="4223.0"/> <glyph class="unit of information" id="_a8079358-a98e-41bd-a9c0-0792dbbdc791"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="20026.0" y="4218.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s158_shh1_shh2_csa15" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:JUN:promoter_region Identifiers_end</body> </html> </notes> <label text="EGF_induced_TF_gene"/> <bbox w="100.0" h="120.0" x="18556.5" y="4327.0"/> <glyph class="macromolecule" id="shh1_shh2_s241_shh1_shh2_sa143"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> </notes> <label text="JUN"/> <bbox w="80.0" h="40.0" x="18567.5" y="4340.0"/> <glyph class="state variable" id="_35e15d4c-74c9-42c8-b2a1-d92bc427195d"> <state value="P" variable="S63"/> <bbox w="30.0" h="10.0" x="18552.992" y="4335.0"/> </glyph> <glyph class="state variable" id="_a8e1c506-51c9-4179-abf3-99ac4b6cdedc"> <state value="P" variable="S73"/> <bbox w="30.0" h="10.0" x="18592.531" y="4335.0"/> </glyph> <glyph class="state variable" id="_a804e832-e7d4-4933-bfac-8d4a29e37eb4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18562.5" y="4355.0"/> </glyph> <glyph class="state variable" id="_dbff0b72-ca9f-4d34-bf4c-c55d80b19407"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18562.5" y="4335.0"/> </glyph> <glyph class="state variable" id="_1ab33de2-c96b-4f8a-b134-5982cee3bb07"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18562.5" y="4375.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_shh2_s159_shh1_shh2_sa144"> <label text="promoter_region"/> <bbox w="70.0" h="25.0" x="18572.5" y="4384.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s183_shh1_shh2_csa17" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:LEF_TCF*:_beta_-Catenin*:promoter_region Identifiers_end References_begin: s_shh2_re101:(MAP:survival) PMID:18057099 References_end</body> </html> </notes> <label text="tcf_beta-catenin_gene"/> <bbox w="105.0" h="147.0" x="19000.0" y="4226.0"/> <glyph class="macromolecule" id="shh1_shh2_s181_shh1_shh2_sa162"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 transcription factor 7-like 1 (T-cell specific HMG-box) TCF3 HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 transcription factor 7-like 2 (T-cell specific HMG-box) TCF4 HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end</body> </html> Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end</body> </html> </notes> <label text="LEF_TCF*"/> <bbox w="80.0" h="40.0" x="19011.75" y="4231.0"/> <glyph class="state variable" id="_3f05533b-cf62-49f7-9a15-a4e1f166ff87"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19086.75" y="4226.878"/> </glyph> <glyph class="state variable" id="_e912d199-c25e-432d-94df-80ccae6c8324"> <state value="" variable="S40"/> <bbox w="25.0" h="10.0" x="19079.25" y="4262.6143"/> </glyph> <glyph class="state variable" id="_bb08f5bb-f50c-4802-84fe-754435f9735a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19086.75" y="4246.0"/> </glyph> <glyph class="state variable" id="_036b6425-dc8b-418a-bf67-08d84a7151f9"> <state value="" variable="S166"/> <bbox w="30.0" h="10.0" x="18997.242" y="4226.0"/> </glyph> <glyph class="state variable" id="_ee607f1e-33af-4f9d-a45a-4e55e6ee548b"> <state value="" variable="T155"/> <bbox w="30.0" h="10.0" x="18996.75" y="4265.722"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh2_s182_shh1_shh2_sa163"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="19011.75" y="4278.0"/> <glyph class="state variable" id="_4bdfd9a5-d601-4a52-ba34-1e7bc0e2acbb"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="19039.154" y="4313.0"/> </glyph> <glyph class="state variable" id="_d18e861a-0a82-4dc7-9f2a-7b21294871e4"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="19078.63" y="4313.0"/> </glyph> <glyph class="state variable" id="_940b3844-8ba8-41c3-8657-bc82fbd7c7f3"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="19079.25" y="4273.215"/> </glyph> <glyph class="state variable" id="_098459d6-b23f-4bfe-b5cd-9b6ce22c50ce"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="19039.281" y="4273.0"/> </glyph> <glyph class="state variable" id="_6d21304a-fb1d-41db-9a0c-c7e46d0bdee1"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="18999.742" y="4273.0"/> </glyph> <glyph class="state variable" id="_6415ba36-318f-416a-84d1-85ab5ccbfc45"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="18999.25" y="4312.722"/> </glyph> <glyph class="state variable" id="_d16d64fb-8f34-44ca-91f5-f4d8dd78307f"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="19076.75" y="4273.215"/> </glyph> <glyph class="state variable" id="_b9db02e9-fb05-4255-883b-35f128463e17"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="19076.75" y="4273.215"/> </glyph> <glyph class="state variable" id="_76e13fda-70e5-45eb-ae2b-a7b94283634a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19006.75" y="4293.0"/> </glyph> <glyph class="state variable" id="_e8b43109-4712-436d-a703-4fb8e341308d"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="18997.242" y="4273.0"/> </glyph> <glyph class="state variable" id="_8c923d9d-ad70-44a3-af72-f96d482a926b"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="19076.75" y="4273.215"/> </glyph> <glyph class="state variable" id="_6c6e8114-678f-45f1-a0d9-c8f35216295c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19006.75" y="4284.716"/> </glyph> <glyph class="state variable" id="_2509dbde-7abd-48df-b1fe-e0cfef206010"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="19076.75" y="4273.215"/> </glyph> <glyph class="state variable" id="_982d09f8-875b-4206-9767-7fdb84abf508"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19006.75" y="4293.0"/> </glyph> <glyph class="state variable" id="_ccbac8b4-6901-4f9e-95fb-9ed8d282f878"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="19076.13" y="4313.0"/> </glyph> <glyph class="state variable" id="_c6c7acde-91fc-4486-b5a1-89283cc54654"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="19076.75" y="4273.215"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_shh2_s184_shh1_shh2_sa164"> <label text="promoter_region"/> <bbox w="70.0" h="25.0" x="19016.75" y="4324.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s302_shh1_shh2_csa34" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MIR17-3P*:TSP1* Identifiers_end References_begin: s_shh2_re149(MAP:survival): PMID:16878133 PMID:18550634 Not known which miRNA of the miR-17-92 polycistron is reponsible for degradation of Tsp1 and CTGF not known which miRNA is responsible therefor miR-17-3p is shown in complex s_shh2_re150(MAP:survival): Not known which miRNA of the miR-17-92 polycistron is reponsible for degradation of Tsp1 and CTGF therefor only miR-17-3p shown in complex References_end</body> </html> </notes> <label text="MIR17-92_TSP1"/> <bbox w="100.0" h="120.0" x="19840.0" y="4464.0"/> <glyph class="nucleic acid feature" id="shh1_shh2_s303_shh1_shh2_sa262"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: thrombospondin 1 HUGO:THBS1 HGNC:11785 ENTREZ:7057 UNIPROT:P07996 GENECARDS:THBS1 REACTOME:66519 KEGG:7057 ATLASONC:THBS1ID42548ch15q15 WIKI:THBS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18193162 References_end</body> </html> </notes> <label text="TSP1*"/> <bbox w="90.0" h="25.0" x="19846.5" y="4504.0"/> <glyph class="unit of information" id="_ce4a9cc3-6b49-48ae-b9c1-9c47d0e96d91"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="19881.5" y="4499.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_shh2_s304_shh1_shh2_sa263"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 17 HUGO:MIR17 HGNC:31547 ENTREZ:406952 GENECARDS:MIR17 KEGG:406952 ATLASONC:GC_MIR17 WIKI:MIR17 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20851997 References_end</body> </html> </notes> <label text="MIR17-3P*"/> <bbox w="90.0" h="25.0" x="19846.5" y="4476.0"/> <glyph class="unit of information" id="_2b1678c0-b3e7-4121-b8a4-93ff3b3d1444"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="19876.5" y="4471.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s306_shh1_shh2_csa35" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MIR17-5P*:STAT3 Identifiers_end References_begin: s_shh2_re152:(MAP:survival) PMID:21383238 References_end</body> </html> </notes> <label text="miR-17-5p_STAT3"/> <bbox w="100.0" h="120.0" x="19984.0" y="4464.0"/> <glyph class="nucleic acid feature" id="shh1_shh2_s308_shh1_shh2_sa265"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 17 HUGO:MIR17 HGNC:31547 ENTREZ:406952 GENECARDS:MIR17 KEGG:406952 ATLASONC:GC_MIR17 WIKI:MIR17 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20851997 References_end</body> </html> </notes> <label text="MIR17-5P*"/> <bbox w="90.0" h="25.0" x="19990.5" y="4479.0"/> <glyph class="unit of information" id="_e9d40be9-9fd0-4317-b281-343338691482"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="20020.5" y="4474.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_shh2_s307_shh1_shh2_sa268"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: signal transducer and activator of transcription 3 HUGO:STAT3 HGNC:11364 ENTREZ:6774 UNIPROT:P40763 GENECARDS:STAT3 REACTOME:403956 KEGG:6774 ATLASONC:STAT3ID444 WIKI:STAT3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19424782 References_end</body> </html> </notes> <label text="STAT3"/> <bbox w="90.0" h="25.0" x="19990.5" y="4506.0"/> <glyph class="unit of information" id="_9612fce9-7347-425d-a3a0-5202419580bd"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="20025.5" y="4501.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s319_shh1_shh2_csa39" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MIR19A:TNF-_alpha_* Identifiers_end References_begin: s_shh2_re156:(MAP:survival) PMID:21271217 References_end</body> </html> </notes> <label text="miR-19a_TNF"/> <bbox w="100.0" h="120.0" x="20118.0" y="4037.0"/> <glyph class="nucleic acid feature" id="shh1_shh2_s320_shh1_shh2_sa275"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: TNF-alpha HUGO:TNF HGNC:11892 ENTREZ:7124 UNIPROT:P01375 GENECARDS:TNF REACTOME:66221 KEGG:7124 ATLASONC:TNFaID319 WIKI:TNF Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21555371 References_end</body> </html> </notes> <label text="TNF-α*"/> <bbox w="90.0" h="25.0" x="20123.0" y="4079.0"/> <glyph class="unit of information" id="_5efae325-2482-4032-a0d4-737c865c56dc"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="20158.0" y="4074.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_shh2_s321_shh1_shh2_sa276"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 19a HUGO:MIR19A HGNC:31574 ENTREZ:406979 GENECARDS:MIR19A KEGG:406979 ATLASONC:GC_MIR19A WIKI:MIR19A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20851997 References_end</body> </html> </notes> <label text="MIR19A"/> <bbox w="90.0" h="25.0" x="20123.0" y="4049.0"/> <glyph class="unit of information" id="_ae88d489-e97b-434c-ad64-b046d6fbd610"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="20153.0" y="4044.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s309_shh1_shh2_csa36" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MIR20A:STAT3 Identifiers_end References_begin: s_shh2_re153:(MAP:survival) PMID:21383238 References_end</body> </html> </notes> <label text="miR-20a_STAT3"/> <bbox w="100.0" h="120.0" x="19688.0" y="4616.0"/> <glyph class="nucleic acid feature" id="shh1_shh2_s311_shh1_shh2_sa266"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 20a HUGO:MIR20A HGNC:31577 ENTREZ:406982 GENECARDS:MIR20A KEGG:406982 ATLASONC:GC_MIR20A WIKI:MIR20A Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20851997 References_end</body> </html> </notes> <label text="MIR20A"/> <bbox w="90.0" h="25.0" x="19695.0" y="4630.0"/> <glyph class="unit of information" id="_a31810e4-268b-4334-ac90-d43b15764f3c"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="19725.0" y="4625.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_shh2_s310_shh1_shh2_sa267"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: signal transducer and activator of transcription 3 HUGO:STAT3 HGNC:11364 ENTREZ:6774 UNIPROT:P40763 GENECARDS:STAT3 REACTOME:403956 KEGG:6774 ATLASONC:STAT3ID444 WIKI:STAT3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19424782 References_end</body> </html> </notes> <label text="STAT3"/> <bbox w="90.0" h="25.0" x="19695.0" y="4657.0"/> <glyph class="unit of information" id="_1849880e-7c97-4bf4-ba5f-c9352b1b82db"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="19730.0" y="4652.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s250_shh1_shh2_csa25" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MIR29B*:PTEN Identifiers_end References_begin: s_shh2_re123:(MAP:survival) PMID:21359530 s_shh2_re158:(MAP:survival) PMID:18460397 References_end</body> </html> </notes> <label text="miR-29b_PTEN"/> <bbox w="100.0" h="120.0" x="19691.0" y="4036.0"/> <glyph class="nucleic acid feature" id="shh1_shh2_s251_shh1_shh2_sa218"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 29b-1 HUGO:MIR29B1 HGNC:31619 ENTREZ:407024 GENECARDS:MIR29B1 KEGG:407024 ATLASONC:GC_MIR29B1 WIKI:MIR29B1 HUGO:MIR29B*1 HGNC:31619 ENTREZ:407024 GENECARDS:MIR29B*1 WIKI:MIR29B*1 microRNA 29b-2 HUGO:MIR29B2 HGNC:31620 ENTREZ:407025 GENECARDS:MIR29B2 KEGG:407025 ATLASONC:GC_MIR29B2 WIKI:MIR29B2 HUGO:MIR29B*2 HGNC:31620 ENTREZ:407025 GENECARDS:MIR29B*2 WIKI:MIR29B*2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21359530 References_end</body> </html> </notes> <label text="MIR29B*"/> <bbox w="90.0" h="25.0" x="19698.5" y="4051.0"/> <glyph class="unit of information" id="_fe0867ea-232c-42d0-b99d-251fe36bbbba"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="19728.5" y="4046.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_shh2_s249_shh1_shh2_sa219"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homo Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homo Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end</body> </html> </notes> <label text="PTEN"/> <bbox w="90.0" h="25.0" x="19698.5" y="4084.0"/> <glyph class="unit of information" id="_eefdff37-ade1-4f21-8d34-91f93b672eef"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="19733.5" y="4079.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh2_s287_shh1_shh2_csa31" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MYCN:promoter_region Identifiers_end References_begin: s_shh2_re135:(MAP:survival) PMID:20851997 PMID:19351822 References_end</body> </html> </notes> <label text="N-MYC_miR-17-92 polycistron"/> <bbox w="102.0" h="100.0" x="19034.0" y="4662.0"/> <glyph class="macromolecule" id="shh1_shh2_s289_shh1_shh2_sa251"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: N-myc HUGO:MYCN HGNC:7559 ENTREZ:4613 UNIPROT:P04198 GENECARDS:MYCN KEGG:4613 ATLASONC:NMYC112 WIKI:MYCN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:15061133 References_end</body> </html> </notes> <label text="MYCN"/> <bbox w="80.0" h="40.0" x="19045.625" y="4670.0"/> </glyph> <glyph class="nucleic acid feature" id="shh1_shh2_s288_shh1_shh2_sa252"> <label text="promoter_region"/> <bbox w="70.0" h="25.0" x="19050.75" y="4712.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s170_shh1_shh2_sa152" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re97:(MAP:survival) PMID:19190345 PMID:16880536 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Activity-regulated cytoskeleton-associated protein HUGO:ARC HGNC:648 ENTREZ:23237 UNIPROT:Q7LC44 GENECARDS:ARC KEGG:8996 ATLASONC:GC_ARC WIKI:ARC Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16599904 References_end</body> </html> </notes> <label text="ARC"/> <bbox w="70.0" h="25.0" x="18688.0" y="4321.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s94_shh1_shh2_sa88" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re58:(MAP:survival) PMID:15520176 PMID:14555646 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: B-cell CLL/lymphoma 2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: Bcl-2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 GENECARDS:BCL2 REACTOME:50758 KEGG:596 ATLASONC:BCL2ID49 WIKI:BCL2 B-cell CLL/lymphoma 2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18097445 PMID:9735050 References_end Identifiers_begin: Bcl-2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 GENECARDS:BCL2 REACTOME:50758 KEGG:596 ATLASONC:BCL2ID49 WIKI:BCL2 B-cell CLL/lymphoma 2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18097445 PMID:9735050 References_end</body> </html> </notes> <label text="BCL2"/> <bbox w="70.0" h="25.0" x="18688.0" y="4015.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s70_shh1_shh2_sa64" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re42:(MAP:survival) PMID:16396903 PMID:20107231 PMID:16054035 PMID:16406505 PMID:16880536 PMID:17000779 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 "B-cell CLL/lymphoma 1" "G1/S-specific cyclin D1" "parathyroid adenomatosis 1" U21B31 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18414028 PMID:20673124 PMID:19887899 References_end Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 "B-cell CLL/lymphoma 1" "G1/S-specific cyclin D1" "parathyroid adenomatosis 1" U21B31 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18414028 PMID:20673124 PMID:19887899 References_end Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 "B-cell CLL/lymphoma 1" "G1/S-specific cyclin D1" "parathyroid adenomatosis 1" U21B31 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18414028 PMID:20673124 PMID:19887899 References_end</body> </html> </notes> <label text="CyclinD*"/> <bbox w="70.0" h="25.0" x="18688.0" y="3805.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s18_shh1_shh2_sa14" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re4:(MAP:survival) PMID:20562908 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Tumor necrosis factor receptor superfamily member 10a HUGO:TNFRSF10A HGNC:11904 ENTREZ:8797 UNIPROT:O00220 GENECARDS:TNFRSF10A KEGG:8797 ATLASONC:GC_TNFRSF10A WIKI:TNFRSF10A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20562908 References_end</body> </html> </notes> <label text="Death receptor4*"/> <bbox w="70.0" h="25.0" x="18687.0" y="3033.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s51_shh1_shh2_sa45" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re22:(MAP:survival) PMID:18813803 PMID:16880536 PMID:19190345 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Forkhead box A2 HUGO:FOXA2 HGNC:5022 ENTREZ:3170 UNIPROT:Q9Y261 GENECARDS:FOXA2 REACTOME:56610 KEGG:3170 ATLASONC:GC_FOXA2 WIKI:FOXA2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16909212 Forkhead box References_end</body> </html> </notes> <label text="FOXA2"/> <bbox w="70.0" h="25.0" x="18687.0" y="3216.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s54_shh1_shh2_sa48" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re25:(MAP:survival) PMID:18813803 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Forkhead box C2 HUGO:FOXC2 HGNC:3801 ENTREZ:2303 UNIPROT:Q99958 GENECARDS:FOXC2 KEGG:2303 ATLASONC:GC_FOXC2 WIKI:FOXC2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20713713 PMID:18539112 Forkhead box References_end</body> </html> </notes> <label text="FOXC2"/> <bbox w="70.0" h="25.0" x="18687.0" y="3264.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s66_shh1_shh2_sa60" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re38:(MAP:survival) PMID:15140221 PMID:18813803 PMID:18698484 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Forkhead box E1 HUGO:FOXE1 HGNC:3806 ENTREZ:2304 UNIPROT:O00358 GENECARDS:FOXE1 KEGG:2304 ATLASONC:FOXE1ID47197ch9q22 WIKI:FOXE1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:15140221 PMID:18698484 Forkhead box References_end</body> </html> </notes> <label text="FOXE1"/> <bbox w="70.0" h="25.0" x="18687.0" y="3312.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s46_shh1_shh2_sa40" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re20(MAP:survival): PMID:19049965 PMID:11493558 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Forkhead box F1 HUGO:FOXF1 HGNC:3809 ENTREZ:2294 UNIPROT:Q12946 GENECARDS:FOXF1 KEGG:2294 ATLASONC:FOXF1ID40628ch16q24 WIKI:FOXF1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19424602 PMID:20587515 PMID:19049965 PMID:11493558 PMID:20145151 Forkhead box References_end</body> </html> </notes> <label text="FOXF1"/> <bbox w="70.0" h="25.0" x="18687.0" y="3124.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s48_shh1_shh2_sa42" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re19:(MAP:survival) PMID:19049965 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Forkhead box L1 HUGO:FOXL1 HGNC:3817 ENTREZ:2300 UNIPROT:Q12952 GENECARDS:FOXL1 KEGG:2300 ATLASONC:GC_FOXL1 WIKI:FOXL1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20145151 Forkhead box References_end</body> </html> </notes> <label text="FOXL1"/> <bbox w="70.0" h="25.0" x="18687.0" y="3170.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s68_shh1_shh2_sa62" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re40:(MAP:survival) PMID:20712011 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Forkhead box M1 HUGO:FOXM1 HGNC:3818 ENTREZ:2305 UNIPROT:Q08050 GENECARDS:FOXM1 KEGG:2305 ATLASONC:FOXM1ID40631ch12p13 WIKI:FOXM1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20712011 PMID:21062979 Forkhead box References_end</body> </html> </notes> <label text="FOXM1"/> <bbox w="70.0" h="25.0" x="18687.0" y="3358.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s56_shh1_shh2_sa50" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re28:(MAP:survival) PMID:18813803 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Forkhead box P3 HUGO:FOXP3 HGNC:6106 ENTREZ:50943 UNIPROT:Q9BZS1 GENECARDS:FOXP3 KEGG:50943 ATLASONC:FOXP3ID44129chXp11 WIKI:FOXP3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20678582 PMID:21034673 Forkhead box References_end</body> </html> </notes> <label text="FOXP3"/> <bbox w="70.0" h="25.0" x="18688.0" y="3400.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s58_shh1_shh2_sa52" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re32:(MAP:survival) PMID:18813803 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Forkhead box Q1 HUGO:FOXQ1 HGNC:20951 ENTREZ:94234 UNIPROT:Q9C009 GENECARDS:FOXQ1 KEGG:94234 ATLASONC:GC_FOXQ1 WIKI:FOXQ1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21285253 PMID:21346143 Forkhead box References_end</body> </html> </notes> <label text="FOXQ1"/> <bbox w="70.0" h="25.0" x="18688.0" y="3445.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s83_shh1_shh2_sa77" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re51(MAP:survival): PMID:9216996 PMID:16413481 PMID:17000779 ANNOTATION: it was shown that Med12 binds to Gli1 promoter References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 1 HUGO:GLI1 HGNC:4317 ENTREZ:2735 UNIPROT:P08151 GENECARDS:GLI1 KEGG:2735 ATLASONC:GLIID310ch12q13 WIKI:GLI1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI1"/> <bbox w="70.0" h="25.0" x="18688.0" y="3717.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s85_shh1_shh2_sa79" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re52:(MAP:survival) PMID:16396903 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 2 HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18497536 PMID:17845852 PMID:11001584 References_end</body> </html> </notes> <label text="GLI2"/> <bbox w="70.0" h="25.0" x="18688.0" y="3759.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s185_shh1_shh2_sa165" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re101:(MAP:survival) PMID:18057099 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 3 HUGO:GLI3 HGNC:4319 ENTREZ:2737 UNIPROT:P10071 GENECARDS:GLI3 KEGG:2737 ATLASONC:GC_GLI3 WIKI:GLI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI3"/> <bbox w="70.0" h="25.0" x="18688.0" y="4391.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s125_shh1_shh2_sa113" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re73:(MAP:survival) PMID:16571352 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Hip1 HUGO:HIP1 HGNC:4913 ENTREZ:3092 UNIPROT:O00291 GENECARDS:HIP1 KEGG:3092 ATLASONC:HIP1ID138 WIKI:HIP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16571352 PMID:10050855 References_end</body> </html> </notes> <label text="HIP1*"/> <bbox w="70.0" h="25.0" x="18699.0" y="4059.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s92_shh1_shh2_sa86" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re57:(MAP:survival) PMID:19736394 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Insuline-like growth factor binding protein 6 HUGO:IGFBP6 HGNC:5475 ENTREZ:3489 UNIPROT:P24592 GENECARDS:IGFBP6 REACTOME:381521 KEGG:3489 ATLASONC:GC_IGFBP6 WIKI:IGFBP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19736394 References_end</body> </html> </notes> <label text="IGFBP6"/> <bbox w="70.0" h="25.0" x="18688.0" y="3971.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s149_shh1_shh2_sa135" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re86:(MAP:survival) PMID:19190345 PMID:16880536 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Interleukin 1 receptor type II HUGO:IL1R2 HGNC:5994 ENTREZ:7850 UNIPROT:P27930 GENECARDS:IL1R2 REACTOME:57242 KEGG:7850 ATLASONC:GC_IL1R2 WIKI:IL1R2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:12606705 References_end</body> </html> </notes> <label text="IL1R2"/> <bbox w="70.0" h="25.0" x="18688.0" y="4216.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s63_shh1_shh2_sa57" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re36:(MAP:survival) PMID:16880536 PMID:18813803 PMID:19190345 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Jagged 2 HUGO:JAG2 HGNC:6189 ENTREZ:3714 UNIPROT:Q9Y219 GENECARDS:JAG2 REACTOME:57643 KEGG:3714 ATLASONC:JAG2ID41030ch14q32 WIKI:JAG2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19398556 References_end</body> </html> </notes> <label text="JAG2"/> <bbox w="70.0" h="25.0" x="18688.0" y="3535.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s142_shh1_shh2_sa129" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re82:(MAP:survival) PMID:19219074 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 References_end</body> </html> </notes> <label text="JUN"/> <bbox w="70.0" h="25.0" x="18688.0" y="4180.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s279_shh1_shh2_sa243" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re135:(MAP:survival) PMID:20851997 PMID:19351822 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 17-92 cluster HUGO:MIR17HG HGNC:23564 ENTREZ:407975 UNIPROT:Q75NE6 GENECARDS:MIR17HG KEGG:407975 ATLASONC:GC_MIR17HG WIKI:MIR17HG Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20885820 PMID:17060945 References_end</body> </html> </notes> <label text="MIR17-92*"/> <bbox w="70.0" h="25.0" x="19045.0" y="4620.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s244_shh1_shh2_sa212" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re121(MAP:survival): PMID:20564213 ANNOTATION: Not clear how suprresion is regulated by Hedgehog References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 29b-1 HUGO:MIR29B1 HGNC:31619 ENTREZ:407024 GENECARDS:MIR29B1 KEGG:407024 ATLASONC:GC_MIR29B1 WIKI:MIR29B1 HUGO:MIR29B*1 HGNC:31619 ENTREZ:407024 GENECARDS:MIR29B*1 WIKI:MIR29B*1 microRNA 29b-2 HUGO:MIR29B2 HGNC:31620 ENTREZ:407025 GENECARDS:MIR29B2 KEGG:407025 ATLASONC:GC_MIR29B2 WIKI:MIR29B2 HUGO:MIR29B*2 HGNC:31620 ENTREZ:407025 GENECARDS:MIR29B*2 WIKI:MIR29B*2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21359530 References_end</body> </html> </notes> <label text="MIR29B*"/> <bbox w="70.0" h="25.0" x="18688.0" y="4601.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s248_shh1_shh2_sa216" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re122:(MAP:survival) PMID:19351822 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: microRNA 378 HUGO:MIR378 GENECARDS:MIR378 KEGG:494327 WIKI:MIR378 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19446450 PMID:18077375 References_end</body> </html> </notes> <label text="MIR378"/> <bbox w="70.0" h="25.0" x="18688.0" y="4645.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s187_shh1_shh2_sa167" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re102(MAP:survival): PMID:21442356 Not sure if direct interaction of gli1 with gene References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Matrix metallopeptidase 11 HUGO:MMP11 HGNC:7157 ENTREZ:4320 UNIPROT:P24347 GENECARDS:MMP11 REACTOME:59399 KEGG:4320 ATLASONC:ST3ID200 WIKI:MMP11 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16710861 PMID:15781316 References_end</body> </html> </notes> <label text="MMP11"/> <bbox w="70.0" h="25.0" x="18688.0" y="4425.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s127_shh1_shh2_sa115" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re74:(MAP:survival) PMID:16054035 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-myc myelocytomatosis viral related oncogene neuroblastoma derived HUGO:MYCN HGNC:7559 ENTREZ:4613 UNIPROT:P04198 GENECARDS:MYCN KEGG:4613 ATLASONC:NMYC112 WIKI:MYCN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:15061133 References_end</body> </html> </notes> <label text="MYCN"/> <bbox w="70.0" h="25.0" x="18688.0" y="4099.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s90_shh1_shh2_sa84" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re55:(MAP:survival) PMID:21059263 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NK2 Homeobox 2 HUGO:NKX2-2 HGNC:7835 ENTREZ:4821 UNIPROT:O95096 GENECARDS:NKX2-2 REACTOME:60235 KEGG:4821 ATLASONC:NKX22ID44177ch20p11 WIKI:NKX2-2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21169405 References_end</body> </html> </notes> <label text="NKX2-2"/> <bbox w="70.0" h="25.0" x="18688.0" y="3931.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s88_shh1_shh2_sa82" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re53:(MAP:survival) PMID:21059263 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Paired box 6 HUGO:PAX6 HGNC:8620 ENTREZ:5080 UNIPROT:P26367 GENECARDS:PAX6 REACTOME:403472 KEGG:5080 ATLASONC:PAX6ID211ch11p13 WIKI:PAX6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:12970747 PMID:19651775 References_end</body> </html> </notes> <label text="PAX6"/> <bbox w="70.0" h="25.0" x="18688.0" y="3850.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s191_shh1_shh2_sa171" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re106:(MAP:survival) PMID:16169709 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Paired box 9 HUGO:PAX9 HGNC:8623 ENTREZ:5083 UNIPROT:P55771 GENECARDS:PAX9 KEGG:5083 ATLASONC:PAX9ID41644ch14q12 WIKI:PAX9 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:12970747 PMID:18979497 References_end</body> </html> </notes> <label text="PAX9"/> <bbox w="70.0" h="25.0" x="18688.0" y="3891.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s74_shh1_shh2_sa68" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re45:(MAP:survival) PMID:15087129 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Patched 1 HUGO:PTCH1 HGNC:9585 ENTREZ:5727 UNIPROT:Q13635 GENECARDS:PTCH1 REACTOME:62393 KEGG:5727 ATLASONC:PTCH100 WIKI:PTCH1 Patched 2 HUGO:PTCH2 HGNC:9586 ENTREZ:8643 UNIPROT:Q9Y6C5 GENECARDS:PTCH2 REACTOME:62395 KEGG:8643 ATLASONC:PTCH2ID41892ch1p34 WIKI:PTCH2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:10021362 PMID:17641202 References_end</body> </html> </notes> <label text="PTCH1"/> <bbox w="70.0" h="25.0" x="18688.0" y="3634.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s60_shh1_shh2_sa54" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re34:(MAP:survival) PMID:18813803 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Runt-related transcription factor 2 HUGO:RUNX2 HGNC:10472 ENTREZ:860 UNIPROT:Q13950 GENECARDS:RUNX2 REACTOME:63858 KEGG:860 ATLASONC:RUNX2ID42183ch6p21 WIKI:RUNX2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20946121 PMID:20580290 References_end</body> </html> </notes> <label text="RUNX2"/> <bbox w="70.0" h="25.0" x="18688.0" y="3492.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s166_shh1_shh2_sa148" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re94:(MAP:survival) PMID:16880536 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: S100 calcium binding protein A7 HUGO:S100A7 HGNC:10497 ENTREZ:6278 UNIPROT:P31151 GENECARDS:S100A7 KEGG:6278 ATLASONC:S100A7ID42194ch1q21 WIKI:S100A7 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21228116 References_end</body> </html> </notes> <label text="S100A7"/> <bbox w="70.0" h="25.0" x="18688.0" y="4287.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s164_shh1_shh2_sa146" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re91:(MAP:survival) PMID:19190345 PMID:16880536 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: S100 calcium binding protein A9 HUGO:S100A9 HGNC:10499 ENTREZ:6280 UNIPROT:P06702 GENECARDS:S100A9 KEGG:6280 ATLASONC:S100A9ID45569ch1q21 WIKI:S100A9 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21228116 References_end</body> </html> </notes> <label text="S100A9"/> <bbox w="70.0" h="25.0" x="18688.0" y="4253.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s39_shh1_shh2_sa33" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re15:(MAP:survival) PMID:17035233 PMID:16328026 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Secreted frizzled-related protein 1 HUGO:SFRP1 HGNC:10776 ENTREZ:6422 UNIPROT:Q8N474 GENECARDS:SFRP1 KEGG:6422 ATLASONC:GC_SFRP1 WIKI:SFRP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20448436 References_end</body> </html> </notes> <label text="SFRP1"/> <bbox w="70.0" h="25.0" x="18687.0" y="3078.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s81_shh1_shh2_sa75" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re49:(MAP:survival) PMID:20143239 PMID:16413481 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Six homeobox 1 HUGO:SIX1 HGNC:10887 ENTREZ:6495 UNIPROT:Q15475 GENECARDS:SIX1 KEGG:6495 ATLASONC:SIX1ID42302ch14q23 WIKI:SIX1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11003839 References_end</body> </html> </notes> <label text="SIX1"/> <bbox w="70.0" h="25.0" x="18688.0" y="3674.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s129_shh1_shh2_sa117" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re77:(MAP:survival) PMID:16158046 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Snail homologue 1 HUGO:SNAI1 HGNC:11128 ENTREZ:6615 UNIPROT:O95863 GENECARDS:SNAI1 KEGG:6615 ATLASONC:SNAI1ID452ch20q13 WIKI:SNAI1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20713713 References_end</body> </html> </notes> <label text="SNAI1"/> <bbox w="70.0" h="25.0" x="18688.0" y="4141.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s72_shh1_shh2_sa66" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re43:(MAP:survival) PMID:9609833 PMID:16413481 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: T-box 2 HUGO:TBX2 HGNC:11597 ENTREZ:6909 UNIPROT:Q13207 GENECARDS:TBX2 ATLASONC:TBX2ID42485ch17q23 WIKI:TBX2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20567632 PMID:19960541 References_end</body> </html> </notes> <label text="TBX2"/> <bbox w="70.0" h="25.0" x="18688.0" y="3586.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s173_shh1_shh2_sa155" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re99:(MAP:survival) PMID:19190345 PMID:16880536 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Unc-51-like kinase 1 HUGO:ULK1 HGNC:12558 ENTREZ:8408 UNIPROT:O75385 GENECARDS:ULK1 KEGG:8408 ATLASONC:GC_ULK1 WIKI:ULK1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20056399 References_end</body> </html> </notes> <label text="ULK1"/> <bbox w="70.0" h="25.0" x="18688.0" y="4356.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s189_shh1_shh2_sa169" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re104:(MAP:survival) PMID:19809516 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21447091 References_end</body> </html> </notes> <label text="WNT11"/> <bbox w="70.0" h="25.0" x="18688.0" y="4463.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s14_shh1_shh2_sa11" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re118:(MAP:survival) PMID:17000779 References_end</body> </html> </notes> <label text="promoter_region"/> <clone/> <bbox w="70.0" h="25.0" x="18275.0" y="3209.5"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s14_shh1_shh2_sa37" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re118:(MAP:survival) PMID:17000779 References_end</body> </html> </notes> <label text="promoter_region"/> <clone/> <bbox w="70.0" h="25.0" x="19521.5" y="3008.6802"/> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s14_shh1_shh2_sa72" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re118:(MAP:survival) PMID:17000779 References_end</body> </html> </notes> <label text="promoter_region"/> <clone/> <bbox w="70.0" h="25.0" x="19826.5" y="3036.0"/> </glyph> <glyph class="phenotype" id="shh1_s_shh2_s299_shh1_shh2_sa145" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <label text="Angiogenesis"/> <bbox w="80.0" h="30.0" x="19135.0" y="3649.0"/> </glyph> <glyph class="phenotype" id="shh1_s_shh2_s21_shh1_shh2_sa17" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re114:(MAP:survival) PMID:18379348 References_end</body> </html> </notes> <label text="Apoptosis"/> <bbox w="80.0" h="30.0" x="19137.0" y="3074.0"/> </glyph> <glyph class="phenotype" id="shh1_s_shh2_s175_shh1_shh2_sa157" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re100:(MAP:survival) PMID:19211835 References_end</body> </html> </notes> <label text="Autophagy"/> <bbox w="80.0" h="30.0" x="19135.0" y="3818.0"/> </glyph> <glyph class="phenotype" id="shh1_s_shh2_s62_shh1_shh2_sa56" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re35:(MAP:survival) PMID:20946121 s_shh2_re54:(MAP:survival) PMID:19651775 References_end</body> </html> </notes> <label text="Cancer progression ER-neg"/> <bbox w="80.0" h="30.0" x="19135.0" y="3337.0"/> </glyph> <glyph class="phenotype" id="shh1_s_shh2_s96_shh1_shh2_sa90" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re60:(MAP:survival) PMID:19736394 s_shh2_re107:(MAP:survival) PMID:18979497 References_end</body> </html> </notes> <label text="Cell survival"/> <bbox w="80.0" h="30.0" x="19135.0" y="3464.0"/> </glyph> <glyph class="phenotype" id="shh1_s_shh2_s50_shh1_shh2_sa44" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re21:(MAP:survival) PMID:20145151 s_shh2_re27:(MAP:survival) PMID:18539112 s_shh2_re33:(MAP:survival) PMID:21285253 PMID:21346143 s_shh2_re78:(MAP:survival) PMID:16158046 s_shh2_re103:(MAP:survival) PMID:21442356 References_end</body> </html> </notes> <label text="EMT"/> <bbox w="80.0" h="30.0" x="19137.0" y="3205.0"/> </glyph> <glyph class="phenotype" id="shh1_s_shh2_s146_shh1_shh2_sa132" compartmentRef="shh1_shh2_c3_shh1_shh2_ca3"> <label text="JNK pathway"/> <bbox w="80.0" h="30.0" x="18085.0" y="2863.0"/> </glyph> <glyph class="phenotype" id="shh1_s_shh2_s151_shh1_shh2_sa137" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re87(MAP:survival): Maps_Modules_end Identifiers_end s_shh2_re93:(MAP:survival) PMID:21228116 References_end</body> </html> </notes> <label text="MAPK pathway"/> <bbox w="80.0" h="30.0" x="19135.0" y="3528.0"/> </glyph> <glyph class="phenotype" id="shh1_s_shh2_s232_shh1_shh2_sa205" compartmentRef="shh1_shh2_c3_shh1_shh2_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16880536 s_wnc3_re15:(MAP:survival) PMID:21376121 References_end</body> </html> </notes> <label text="MAPK pathway"/> <bbox w="80.0" h="30.0" x="18035.0" y="4232.0"/> </glyph> <glyph class="phenotype" id="shh1_s_shh2_s152_shh1_shh2_sa138" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re88:(MAP:survival) PMID:12606705 s_shh2_re92:(MAP:survival) PMID:21228116 References_end</body> </html> </notes> <label text="NF-κB pathway"/> <bbox w="80.0" h="30.0" x="19135.0" y="3590.0"/> </glyph> <glyph class="phenotype" id="shh1_s_shh2_s65_shh1_shh2_sa59" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re37:(MAP:survival) PMID:19398556 References_end</body> </html> </notes> <label text="Notch pathway"/> <bbox w="80.0" h="30.0" x="19135.0" y="3401.0"/> </glyph> <glyph class="phenotype" id="shh1_s_shh2_s169_shh1_shh2_sa151" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re96:(MAP:survival) PMID:15994944 References_end</body> </html> </notes> <label text="PI3K Akt MTOR pathway"/> <bbox w="80.0" h="30.0" x="19135.0" y="3711.0"/> </glyph> <glyph class="phenotype" id="shh1_s_shh2_s53_shh1_shh2_sa47" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re29:(MAP:survival) PMID:20678582 PMID:21034673 s_shh2_re41:(MAP:survival) PMID:20712011 s_shh2_re44:(MAP:survival) PMID:20348948 PMID:19960541 s_shh2_re50:(MAP:survival) PMID:19055944 s_shh2_re56:(MAP:survival) PMID:19581346 s_shh2_re59:(MAP:survival) PMID:19736394 s_shh2_re75:(MAP:survival) PMID:16054035 s_shh2_re76:(MAP:survival) PMID:19574535 s_shh2_re85:(MAP:survival) PMID:16977332 s_shh2_re151(MAP:survival): PMID:18700987 The miR-17-5p drives the cell from G1 to S phase thereby regulating more than 20 genes References_end</body> </html> </notes> <label text="Proliferation"/> <bbox w="80.0" h="30.0" x="19137.0" y="3272.0"/> </glyph> <glyph class="phenotype" id="shh1_s_shh2_s334_shh1_shh2_sa286" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re161:(MAP:survival) PMID:10050855 s_shh2_re162:(MAP:survival) PMID:10021362 s_shh2_re163:(MAP:survival) PMID:16434164 References_end</body> </html> </notes> <label text="Sonic hedgehog pathway"/> <bbox w="80.0" h="30.0" x="19135.0" y="3877.0"/> </glyph> <glyph class="phenotype" id="shh1_s_shh2_s172_shh1_shh2_sa154" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re98:(MAP:survival) PMID:17466953 References_end</body> </html> </notes> <label text="Transcription regulation"/> <bbox w="80.0" h="30.0" x="19135.0" y="3759.0"/> </glyph> <glyph class="phenotype" id="shh1_s_shh2_s41_shh1_shh2_sa35" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re16:(MAP:survival) PMID:16328026 PMID:17035233 s_shh2_re23:(MAP:survival) PMID:19424602 s_shh2_re26:(MAP:survival) PMID:18813803 References_end</body> </html> </notes> <label text="WNT canonical pathway"/> <bbox w="80.0" h="30.0" x="19137.0" y="3134.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s103_shh1_shh2_sa93" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re65:(MAP:survival) PMID:19996099 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <clone/> <bbox w="80.0" h="40.0" x="18411.0" y="3544.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s103_shh1_shh2_sa97" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re65:(MAP:survival) PMID:19996099 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end Identifiers_begin: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta polypeptide HUGO:YWHAB HGNC:12849 ENTREZ:7529 UNIPROT:P31946 GENECARDS:YWHAB REACTOME:48889 KEGG:7529 ATLASONC:GC_YWHAB WIKI:YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon polypeptide HUGO:YWHAE HGNC:12851 ENTREZ:7531 UNIPROT:P62258 GENECARDS:YWHAE REACTOME:48891 KEGG:7531 ATLASONC:GC_YWHAE WIKI:YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma polypeptide HUGO:YWHAG HGNC:12852 ENTREZ:7532 UNIPROT:P61981 GENECARDS:YWHAG REACTOME:48907 KEGG:7532 ATLASONC:GC_YWHAG WIKI:YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta polypeptide HUGO:YWHAH HGNC:12853 ENTREZ:7533 UNIPROT:Q04917 GENECARDS:YWHAH REACTOME:48905 KEGG:7533 ATLASONC:GC_YWHAH WIKI:YWHAH tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta polypeptide HUGO:YWHAQ HGNC:12854 ENTREZ:10971 UNIPROT:P27348 GENECARDS:YWHAQ REACTOME:48915 KEGG:10971 ATLASONC:GC_YWHAQ WIKI:YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta polypeptide HUGO:YWHAZ HGNC:12855 ENTREZ:7534 UNIPROT:P63104 GENECARDS:YWHAZ REACTOME:48917 KEGG:7534 ATLASONC:GC_YWHAZ WIKI:YWHAZ Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:apoptosis / MODULE:TNF_RESPONSE MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18481918 PMID:19027299 References_end</body> </html> </notes> <label text="14-3-3*"/> <clone/> <bbox w="80.0" h="40.0" x="19830.5" y="3764.25"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s226_shh1_shh2_sa200" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re118:(MAP:survival) PMID:17000779 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end Identifiers_begin: CREB binding protein HUGO:CREBBP HGNC:2348 ENTREZ:1387 UNIPROT:Q92793 GENECARDS:CREBBP REACTOME:51510 KEGG:1387 ATLASONC:CBPID42 WIKI:CREBBP cAMP responsive element binding protein 3 HUGO:CREB3 HGNC:2347 ENTREZ:10488 UNIPROT:O43889 GENECARDS:CREB3 KEGG:10488 ATLASONC:GC_CREB3 WIKI:CREB3 cAMP responsive element binding protein 5 HUGO:CREB5 HGNC:16844 ENTREZ:9586 UNIPROT:Q02930 GENECARDS:CREB5 KEGG:9586 WIKI:CREB5 CBP KAT3A RTS Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G2_M_CHECKPOINT MAP:cellcycle / MODULE:E2F1 MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17565603 PMID:15337521 CREB binding protein References_end</body> </html> </notes> <label text="CBP*"/> <bbox w="80.0" h="40.0" x="19597.0" y="3627.0"/> <glyph class="state variable" id="_9707ac8b-4621-4758-a8f1-1be793b729d3"> <state value="" variable="S92"/> <bbox w="25.0" h="10.0" x="19584.992" y="3622.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s23_shh1_shh2_sa20" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re8:(MAP:survival) PMID:12138125 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> </notes> <label text="CRM1*"/> <bbox w="80.0" h="40.0" x="18392.0" y="3452.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s33_shh1_shh2_sa28" compartmentRef="shh1_shh2_c3_shh1_shh2_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re10:(MAP:survival) PMID:12138125 s_akt2_re45:(MAP:survival) PMID:18636226 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end Identifiers_begin: exportin 1 (CRM1 homolog yeast) HUGO:XPO1 HGNC:12825 ENTREZ:7514 UNIPROT:O14980 GENECARDS:XPO1 REACTOME:165526 KEGG:7514 ATLASONC:XPO1ID44168ch2p15 WIKI:XPO1 exportin 1 CRM1 homo "exportin 1 (CRM1 yeast homolog)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18636226 PMID:12529437 References_end</body> </html> </notes> <label text="CRM1*"/> <bbox w="80.0" h="40.0" x="18102.0" y="3448.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s24_shh1_shh2_sa22" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re7:(MAP:survival) PMID:12138125 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A HUGO:DYRK1A HGNC:3091 ENTREZ:1859 UNIPROT:Q13627 GENECARDS:DYRK1A REACTOME:54046 KEGG:1859 ATLASONC:DYRK1AID43234ch21q22 WIKI:DYRK1A DYRK, DYRK1, MNBH Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:11980723 PMID:19685005 Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase References_end Identifiers_begin: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A HUGO:DYRK1A HGNC:3091 ENTREZ:1859 UNIPROT:Q13627 GENECARDS:DYRK1A REACTOME:54046 KEGG:1859 ATLASONC:DYRK1AID43234ch21q22 WIKI:DYRK1A DYRK, DYRK1, MNBH Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:11980723 PMID:19685005 Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase References_end Identifiers_begin: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A HUGO:DYRK1A HGNC:3091 ENTREZ:1859 UNIPROT:Q13627 GENECARDS:DYRK1A REACTOME:54046 KEGG:1859 ATLASONC:DYRK1AID43234ch21q22 WIKI:DYRK1A DYRK, DYRK1, MNBH Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:11980723 PMID:19685005 Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase References_end</body> </html> </notes> <label text="DYRK1A"/> <bbox w="80.0" h="40.0" x="18391.0" y="3397.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s10_shh1_shh2_sa7" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> </notes> <label text="E1*"/> <clone/> <bbox w="80.0" h="40.0" x="19743.5" y="3128.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s10_shh1_shh2_sa107" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> </notes> <label text="E1*"/> <clone/> <bbox w="80.0" h="40.0" x="18382.0" y="3907.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s11_shh1_shh2_sa8" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C ubiquitin-conjugating enzyme E2D 1 HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 ubiquitin-conjugating enzyme E2E 1 HUGO:UBE2E1 HGNC:12477 ENTREZ:7324 UNIPROT:P51965 GENECARDS:UBE2E1 REACTOME:66739 KEGG:7324 ATLASONC:GC_UBE2E1 WIKI:UBE2E1 ubiquitin-conjugating enzyme E2E 2 HUGO:UBE2E2 HGNC:12478 ENTREZ:7325 UNIPROT:Q96LR5 GENECARDS:UBE2E2 REACTOME:155471 KEGG:7325 ATLASONC:GC_UBE2E2 WIKI:UBE2E2 ubiquitin-conjugating enzyme E2G 1 HUGO:UBE2G1 HGNC:12482 ENTREZ:7326 UNIPROT:P62253 GENECARDS:UBE2G1 REACTOME:66753 KEGG:7326 ATLASONC:GC_UBE2G1 WIKI:UBE2G1 ubiquitin-conjugating enzyme E2G 2 HUGO:UBE2G2 HGNC:12483 ENTREZ:7327 UNIPROT:P60604 GENECARDS:UBE2G2 REACTOME:66773 KEGG:7327 ATLASONC:GC_UBE2G2 WIKI:UBE2G2 ubiquitin-conjugating enzyme E2H HUGO:UBE2H HGNC:12484 ENTREZ:7328 UNIPROT:P62256 GENECARDS:UBE2H REACTOME:66759 KEGG:7328 ATLASONC:GC_UBE2H WIKI:UBE2H ubiquitin-conjugating enzyme E2I HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I ubiquitin-conjugating enzyme E2 J1 HUGO:UBE2J1 HGNC:17598 ENTREZ:51465 UNIPROT:Q9Y385 GENECARDS:UBE2J1 REACTOME:155484 KEGG:51465 ATLASONC:GC_UBE2J1 WIKI:UBE2J1 ubiquitin-conjugating enzyme E2 J2 HUGO:UBE2J2 HGNC:19268 ENTREZ:118424 UNIPROT:Q8N2K1 GENECARDS:UBE2J2 REACTOME:155486 KEGG:118424 WIKI:UBE2J2 ubiquitin-conjugating enzyme E2K HUGO:UBE2K HGNC:4914 ENTREZ:3093 UNIPROT:P61086 GENECARDS:UBE2K REACTOME:66723 KEGG:3093 WIKI:UBE2K ubiquitin-conjugating enzyme E2L 3 HUGO:UBE2L3 HGNC:12488 ENTREZ:7332 UNIPROT:P68036 GENECARDS:UBE2L3 REACTOME:66741 KEGG:7332 ATLASONC:GC_UBE2L3 WIKI:UBE2L3 ubiquitin-conjugating enzyme E2L 4 HUGO:UBE2L4 HGNC:12489 ENTREZ:7333 GENECARDS:UBE2L4 WIKI:UBE2L4 ubiquitin-conjugating enzyme E2L 6 HUGO:UBE2L6 HGNC:12490 ENTREZ:9246 UNIPROT:O14933 GENECARDS:UBE2L6 REACTOME:66745 KEGG:9246 ATLASONC:GC_UBE2L6 WIKI:UBE2L6 ubiquitin-conjugating enzyme E2M HUGO:UBE2M HGNC:12491 ENTREZ:9040 UNIPROT:P61081 GENECARDS:UBE2M REACTOME:66777 KEGG:9040 ATLASONC:GC_UBE2M WIKI:UBE2M ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 GENECARDS:UBE2N REACTOME:66781 KEGG:7334 ATLASONC:GC_UBE2N WIKI:UBE2N ubiquitin-conjugating enzyme E2O HUGO:UBE2O HGNC:29554 ENTREZ:63893 UNIPROT:Q9C0C9 GENECARDS:UBE2O REACTOME:253534 KEGG:63893 ATLASONC:GC_UBE2O WIKI:UBE2O ubiquitin-conjugating enzyme E2Q family member 1 HUGO:UBE2Q1 HGNC:15698 ENTREZ:55585 UNIPROT:Q7Z7E8 GENECARDS:UBE2Q1 REACTOME:253474 KEGG:55585 ATLASONC:GC_UBE2Q1 WIKI:UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 2 HUGO:UBE2Q2 HGNC:19248 ENTREZ:92912 UNIPROT:Q8WVN8 GENECARDS:UBE2Q2 REACTOME:253479 ATLASONC:GC_UBE2Q2 WIKI:UBE2Q2 ubiquitin-conjugating enzyme E2R 2 HUGO:UBE2R2 HGNC:19907 ENTREZ:54926 UNIPROT:Q712K3 GENECARDS:UBE2R2 REACTOME:253483 KEGG:54926 ATLASONC:GC_UBE2R2 WIKI:UBE2R2 ubiquitin-conjugating enzyme E2S HUGO:UBE2S HGNC:17895 ENTREZ:27338 UNIPROT:Q16763 GENECARDS:UBE2S REACTOME:66751 KEGG:27338 ATLASONC:GC_UBE2S WIKI:UBE2S ubiquitin-conjugating enzyme E2Z HUGO:UBE2Z HGNC:25847 ENTREZ:65264 UNIPROT:Q9H832 GENECARDS:UBE2Z REACTOME:253545 KEGG:65264 WIKI:UBE2Z Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C ubiquitin-conjugating enzyme E2D 1 HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 ubiquitin-conjugating enzyme E2E 1 HUGO:UBE2E1 HGNC:12477 ENTREZ:7324 UNIPROT:P51965 GENECARDS:UBE2E1 REACTOME:66739 KEGG:7324 ATLASONC:GC_UBE2E1 WIKI:UBE2E1 ubiquitin-conjugating enzyme E2E 2 HUGO:UBE2E2 HGNC:12478 ENTREZ:7325 UNIPROT:Q96LR5 GENECARDS:UBE2E2 REACTOME:155471 KEGG:7325 ATLASONC:GC_UBE2E2 WIKI:UBE2E2 ubiquitin-conjugating enzyme E2G 1 HUGO:UBE2G1 HGNC:12482 ENTREZ:7326 UNIPROT:P62253 GENECARDS:UBE2G1 REACTOME:66753 KEGG:7326 ATLASONC:GC_UBE2G1 WIKI:UBE2G1 ubiquitin-conjugating enzyme E2G 2 HUGO:UBE2G2 HGNC:12483 ENTREZ:7327 UNIPROT:P60604 GENECARDS:UBE2G2 REACTOME:66773 KEGG:7327 ATLASONC:GC_UBE2G2 WIKI:UBE2G2 ubiquitin-conjugating enzyme E2H HUGO:UBE2H HGNC:12484 ENTREZ:7328 UNIPROT:P62256 GENECARDS:UBE2H REACTOME:66759 KEGG:7328 ATLASONC:GC_UBE2H WIKI:UBE2H ubiquitin-conjugating enzyme E2I HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I ubiquitin-conjugating enzyme E2 J1 HUGO:UBE2J1 HGNC:17598 ENTREZ:51465 UNIPROT:Q9Y385 GENECARDS:UBE2J1 REACTOME:155484 KEGG:51465 ATLASONC:GC_UBE2J1 WIKI:UBE2J1 ubiquitin-conjugating enzyme E2 J2 HUGO:UBE2J2 HGNC:19268 ENTREZ:118424 UNIPROT:Q8N2K1 GENECARDS:UBE2J2 REACTOME:155486 KEGG:118424 WIKI:UBE2J2 ubiquitin-conjugating enzyme E2K HUGO:UBE2K HGNC:4914 ENTREZ:3093 UNIPROT:P61086 GENECARDS:UBE2K REACTOME:66723 KEGG:3093 WIKI:UBE2K ubiquitin-conjugating enzyme E2L 3 HUGO:UBE2L3 HGNC:12488 ENTREZ:7332 UNIPROT:P68036 GENECARDS:UBE2L3 REACTOME:66741 KEGG:7332 ATLASONC:GC_UBE2L3 WIKI:UBE2L3 ubiquitin-conjugating enzyme E2L 4 HUGO:UBE2L4 HGNC:12489 ENTREZ:7333 GENECARDS:UBE2L4 WIKI:UBE2L4 ubiquitin-conjugating enzyme E2L 6 HUGO:UBE2L6 HGNC:12490 ENTREZ:9246 UNIPROT:O14933 GENECARDS:UBE2L6 REACTOME:66745 KEGG:9246 ATLASONC:GC_UBE2L6 WIKI:UBE2L6 ubiquitin-conjugating enzyme E2M HUGO:UBE2M HGNC:12491 ENTREZ:9040 UNIPROT:P61081 GENECARDS:UBE2M REACTOME:66777 KEGG:9040 ATLASONC:GC_UBE2M WIKI:UBE2M ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 GENECARDS:UBE2N REACTOME:66781 KEGG:7334 ATLASONC:GC_UBE2N WIKI:UBE2N ubiquitin-conjugating enzyme E2O HUGO:UBE2O HGNC:29554 ENTREZ:63893 UNIPROT:Q9C0C9 GENECARDS:UBE2O REACTOME:253534 KEGG:63893 ATLASONC:GC_UBE2O WIKI:UBE2O ubiquitin-conjugating enzyme E2Q family member 1 HUGO:UBE2Q1 HGNC:15698 ENTREZ:55585 UNIPROT:Q7Z7E8 GENECARDS:UBE2Q1 REACTOME:253474 KEGG:55585 ATLASONC:GC_UBE2Q1 WIKI:UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 2 HUGO:UBE2Q2 HGNC:19248 ENTREZ:92912 UNIPROT:Q8WVN8 GENECARDS:UBE2Q2 REACTOME:253479 ATLASONC:GC_UBE2Q2 WIKI:UBE2Q2 ubiquitin-conjugating enzyme E2R 2 HUGO:UBE2R2 HGNC:19907 ENTREZ:54926 UNIPROT:Q712K3 GENECARDS:UBE2R2 REACTOME:253483 KEGG:54926 ATLASONC:GC_UBE2R2 WIKI:UBE2R2 ubiquitin-conjugating enzyme E2S HUGO:UBE2S HGNC:17895 ENTREZ:27338 UNIPROT:Q16763 GENECARDS:UBE2S REACTOME:66751 KEGG:27338 ATLASONC:GC_UBE2S WIKI:UBE2S ubiquitin-conjugating enzyme E2Z HUGO:UBE2Z HGNC:25847 ENTREZ:65264 UNIPROT:Q9H832 GENECARDS:UBE2Z REACTOME:253545 KEGG:65264 WIKI:UBE2Z Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C ubiquitin-conjugating enzyme E2D 1 HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 ubiquitin-conjugating enzyme E2E 1 HUGO:UBE2E1 HGNC:12477 ENTREZ:7324 UNIPROT:P51965 GENECARDS:UBE2E1 REACTOME:66739 KEGG:7324 ATLASONC:GC_UBE2E1 WIKI:UBE2E1 ubiquitin-conjugating enzyme E2E 2 HUGO:UBE2E2 HGNC:12478 ENTREZ:7325 UNIPROT:Q96LR5 GENECARDS:UBE2E2 REACTOME:155471 KEGG:7325 ATLASONC:GC_UBE2E2 WIKI:UBE2E2 ubiquitin-conjugating enzyme E2G 1 HUGO:UBE2G1 HGNC:12482 ENTREZ:7326 UNIPROT:P62253 GENECARDS:UBE2G1 REACTOME:66753 KEGG:7326 ATLASONC:GC_UBE2G1 WIKI:UBE2G1 ubiquitin-conjugating enzyme E2G 2 HUGO:UBE2G2 HGNC:12483 ENTREZ:7327 UNIPROT:P60604 GENECARDS:UBE2G2 REACTOME:66773 KEGG:7327 ATLASONC:GC_UBE2G2 WIKI:UBE2G2 ubiquitin-conjugating enzyme E2H HUGO:UBE2H HGNC:12484 ENTREZ:7328 UNIPROT:P62256 GENECARDS:UBE2H REACTOME:66759 KEGG:7328 ATLASONC:GC_UBE2H WIKI:UBE2H ubiquitin-conjugating enzyme E2I HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I ubiquitin-conjugating enzyme E2 J1 HUGO:UBE2J1 HGNC:17598 ENTREZ:51465 UNIPROT:Q9Y385 GENECARDS:UBE2J1 REACTOME:155484 KEGG:51465 ATLASONC:GC_UBE2J1 WIKI:UBE2J1 ubiquitin-conjugating enzyme E2 J2 HUGO:UBE2J2 HGNC:19268 ENTREZ:118424 UNIPROT:Q8N2K1 GENECARDS:UBE2J2 REACTOME:155486 KEGG:118424 WIKI:UBE2J2 ubiquitin-conjugating enzyme E2K HUGO:UBE2K HGNC:4914 ENTREZ:3093 UNIPROT:P61086 GENECARDS:UBE2K REACTOME:66723 KEGG:3093 WIKI:UBE2K ubiquitin-conjugating enzyme E2L 3 HUGO:UBE2L3 HGNC:12488 ENTREZ:7332 UNIPROT:P68036 GENECARDS:UBE2L3 REACTOME:66741 KEGG:7332 ATLASONC:GC_UBE2L3 WIKI:UBE2L3 ubiquitin-conjugating enzyme E2L 4 HUGO:UBE2L4 HGNC:12489 ENTREZ:7333 GENECARDS:UBE2L4 WIKI:UBE2L4 ubiquitin-conjugating enzyme E2L 6 HUGO:UBE2L6 HGNC:12490 ENTREZ:9246 UNIPROT:O14933 GENECARDS:UBE2L6 REACTOME:66745 KEGG:9246 ATLASONC:GC_UBE2L6 WIKI:UBE2L6 ubiquitin-conjugating enzyme E2M HUGO:UBE2M HGNC:12491 ENTREZ:9040 UNIPROT:P61081 GENECARDS:UBE2M REACTOME:66777 KEGG:9040 ATLASONC:GC_UBE2M WIKI:UBE2M ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 GENECARDS:UBE2N REACTOME:66781 KEGG:7334 ATLASONC:GC_UBE2N WIKI:UBE2N ubiquitin-conjugating enzyme E2O HUGO:UBE2O HGNC:29554 ENTREZ:63893 UNIPROT:Q9C0C9 GENECARDS:UBE2O REACTOME:253534 KEGG:63893 ATLASONC:GC_UBE2O WIKI:UBE2O ubiquitin-conjugating enzyme E2Q family member 1 HUGO:UBE2Q1 HGNC:15698 ENTREZ:55585 UNIPROT:Q7Z7E8 GENECARDS:UBE2Q1 REACTOME:253474 KEGG:55585 ATLASONC:GC_UBE2Q1 WIKI:UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 2 HUGO:UBE2Q2 HGNC:19248 ENTREZ:92912 UNIPROT:Q8WVN8 GENECARDS:UBE2Q2 REACTOME:253479 ATLASONC:GC_UBE2Q2 WIKI:UBE2Q2 ubiquitin-conjugating enzyme E2R 2 HUGO:UBE2R2 HGNC:19907 ENTREZ:54926 UNIPROT:Q712K3 GENECARDS:UBE2R2 REACTOME:253483 KEGG:54926 ATLASONC:GC_UBE2R2 WIKI:UBE2R2 ubiquitin-conjugating enzyme E2S HUGO:UBE2S HGNC:17895 ENTREZ:27338 UNIPROT:Q16763 GENECARDS:UBE2S REACTOME:66751 KEGG:27338 ATLASONC:GC_UBE2S WIKI:UBE2S ubiquitin-conjugating enzyme E2Z HUGO:UBE2Z HGNC:25847 ENTREZ:65264 UNIPROT:Q9H832 GENECARDS:UBE2Z REACTOME:253545 KEGG:65264 WIKI:UBE2Z Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> </notes> <label text="E2*"/> <clone/> <bbox w="80.0" h="40.0" x="19743.5" y="3222.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s11_shh1_shh2_sa108" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C ubiquitin-conjugating enzyme E2D 1 HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 ubiquitin-conjugating enzyme E2E 1 HUGO:UBE2E1 HGNC:12477 ENTREZ:7324 UNIPROT:P51965 GENECARDS:UBE2E1 REACTOME:66739 KEGG:7324 ATLASONC:GC_UBE2E1 WIKI:UBE2E1 ubiquitin-conjugating enzyme E2E 2 HUGO:UBE2E2 HGNC:12478 ENTREZ:7325 UNIPROT:Q96LR5 GENECARDS:UBE2E2 REACTOME:155471 KEGG:7325 ATLASONC:GC_UBE2E2 WIKI:UBE2E2 ubiquitin-conjugating enzyme E2G 1 HUGO:UBE2G1 HGNC:12482 ENTREZ:7326 UNIPROT:P62253 GENECARDS:UBE2G1 REACTOME:66753 KEGG:7326 ATLASONC:GC_UBE2G1 WIKI:UBE2G1 ubiquitin-conjugating enzyme E2G 2 HUGO:UBE2G2 HGNC:12483 ENTREZ:7327 UNIPROT:P60604 GENECARDS:UBE2G2 REACTOME:66773 KEGG:7327 ATLASONC:GC_UBE2G2 WIKI:UBE2G2 ubiquitin-conjugating enzyme E2H HUGO:UBE2H HGNC:12484 ENTREZ:7328 UNIPROT:P62256 GENECARDS:UBE2H REACTOME:66759 KEGG:7328 ATLASONC:GC_UBE2H WIKI:UBE2H ubiquitin-conjugating enzyme E2I HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I ubiquitin-conjugating enzyme E2 J1 HUGO:UBE2J1 HGNC:17598 ENTREZ:51465 UNIPROT:Q9Y385 GENECARDS:UBE2J1 REACTOME:155484 KEGG:51465 ATLASONC:GC_UBE2J1 WIKI:UBE2J1 ubiquitin-conjugating enzyme E2 J2 HUGO:UBE2J2 HGNC:19268 ENTREZ:118424 UNIPROT:Q8N2K1 GENECARDS:UBE2J2 REACTOME:155486 KEGG:118424 WIKI:UBE2J2 ubiquitin-conjugating enzyme E2K HUGO:UBE2K HGNC:4914 ENTREZ:3093 UNIPROT:P61086 GENECARDS:UBE2K REACTOME:66723 KEGG:3093 WIKI:UBE2K ubiquitin-conjugating enzyme E2L 3 HUGO:UBE2L3 HGNC:12488 ENTREZ:7332 UNIPROT:P68036 GENECARDS:UBE2L3 REACTOME:66741 KEGG:7332 ATLASONC:GC_UBE2L3 WIKI:UBE2L3 ubiquitin-conjugating enzyme E2L 4 HUGO:UBE2L4 HGNC:12489 ENTREZ:7333 GENECARDS:UBE2L4 WIKI:UBE2L4 ubiquitin-conjugating enzyme E2L 6 HUGO:UBE2L6 HGNC:12490 ENTREZ:9246 UNIPROT:O14933 GENECARDS:UBE2L6 REACTOME:66745 KEGG:9246 ATLASONC:GC_UBE2L6 WIKI:UBE2L6 ubiquitin-conjugating enzyme E2M HUGO:UBE2M HGNC:12491 ENTREZ:9040 UNIPROT:P61081 GENECARDS:UBE2M REACTOME:66777 KEGG:9040 ATLASONC:GC_UBE2M WIKI:UBE2M ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 GENECARDS:UBE2N REACTOME:66781 KEGG:7334 ATLASONC:GC_UBE2N WIKI:UBE2N ubiquitin-conjugating enzyme E2O HUGO:UBE2O HGNC:29554 ENTREZ:63893 UNIPROT:Q9C0C9 GENECARDS:UBE2O REACTOME:253534 KEGG:63893 ATLASONC:GC_UBE2O WIKI:UBE2O ubiquitin-conjugating enzyme E2Q family member 1 HUGO:UBE2Q1 HGNC:15698 ENTREZ:55585 UNIPROT:Q7Z7E8 GENECARDS:UBE2Q1 REACTOME:253474 KEGG:55585 ATLASONC:GC_UBE2Q1 WIKI:UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 2 HUGO:UBE2Q2 HGNC:19248 ENTREZ:92912 UNIPROT:Q8WVN8 GENECARDS:UBE2Q2 REACTOME:253479 ATLASONC:GC_UBE2Q2 WIKI:UBE2Q2 ubiquitin-conjugating enzyme E2R 2 HUGO:UBE2R2 HGNC:19907 ENTREZ:54926 UNIPROT:Q712K3 GENECARDS:UBE2R2 REACTOME:253483 KEGG:54926 ATLASONC:GC_UBE2R2 WIKI:UBE2R2 ubiquitin-conjugating enzyme E2S HUGO:UBE2S HGNC:17895 ENTREZ:27338 UNIPROT:Q16763 GENECARDS:UBE2S REACTOME:66751 KEGG:27338 ATLASONC:GC_UBE2S WIKI:UBE2S ubiquitin-conjugating enzyme E2Z HUGO:UBE2Z HGNC:25847 ENTREZ:65264 UNIPROT:Q9H832 GENECARDS:UBE2Z REACTOME:253545 KEGG:65264 WIKI:UBE2Z Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C ubiquitin-conjugating enzyme E2D 1 HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 ubiquitin-conjugating enzyme E2E 1 HUGO:UBE2E1 HGNC:12477 ENTREZ:7324 UNIPROT:P51965 GENECARDS:UBE2E1 REACTOME:66739 KEGG:7324 ATLASONC:GC_UBE2E1 WIKI:UBE2E1 ubiquitin-conjugating enzyme E2E 2 HUGO:UBE2E2 HGNC:12478 ENTREZ:7325 UNIPROT:Q96LR5 GENECARDS:UBE2E2 REACTOME:155471 KEGG:7325 ATLASONC:GC_UBE2E2 WIKI:UBE2E2 ubiquitin-conjugating enzyme E2G 1 HUGO:UBE2G1 HGNC:12482 ENTREZ:7326 UNIPROT:P62253 GENECARDS:UBE2G1 REACTOME:66753 KEGG:7326 ATLASONC:GC_UBE2G1 WIKI:UBE2G1 ubiquitin-conjugating enzyme E2G 2 HUGO:UBE2G2 HGNC:12483 ENTREZ:7327 UNIPROT:P60604 GENECARDS:UBE2G2 REACTOME:66773 KEGG:7327 ATLASONC:GC_UBE2G2 WIKI:UBE2G2 ubiquitin-conjugating enzyme E2H HUGO:UBE2H HGNC:12484 ENTREZ:7328 UNIPROT:P62256 GENECARDS:UBE2H REACTOME:66759 KEGG:7328 ATLASONC:GC_UBE2H WIKI:UBE2H ubiquitin-conjugating enzyme E2I HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I ubiquitin-conjugating enzyme E2 J1 HUGO:UBE2J1 HGNC:17598 ENTREZ:51465 UNIPROT:Q9Y385 GENECARDS:UBE2J1 REACTOME:155484 KEGG:51465 ATLASONC:GC_UBE2J1 WIKI:UBE2J1 ubiquitin-conjugating enzyme E2 J2 HUGO:UBE2J2 HGNC:19268 ENTREZ:118424 UNIPROT:Q8N2K1 GENECARDS:UBE2J2 REACTOME:155486 KEGG:118424 WIKI:UBE2J2 ubiquitin-conjugating enzyme E2K HUGO:UBE2K HGNC:4914 ENTREZ:3093 UNIPROT:P61086 GENECARDS:UBE2K REACTOME:66723 KEGG:3093 WIKI:UBE2K ubiquitin-conjugating enzyme E2L 3 HUGO:UBE2L3 HGNC:12488 ENTREZ:7332 UNIPROT:P68036 GENECARDS:UBE2L3 REACTOME:66741 KEGG:7332 ATLASONC:GC_UBE2L3 WIKI:UBE2L3 ubiquitin-conjugating enzyme E2L 4 HUGO:UBE2L4 HGNC:12489 ENTREZ:7333 GENECARDS:UBE2L4 WIKI:UBE2L4 ubiquitin-conjugating enzyme E2L 6 HUGO:UBE2L6 HGNC:12490 ENTREZ:9246 UNIPROT:O14933 GENECARDS:UBE2L6 REACTOME:66745 KEGG:9246 ATLASONC:GC_UBE2L6 WIKI:UBE2L6 ubiquitin-conjugating enzyme E2M HUGO:UBE2M HGNC:12491 ENTREZ:9040 UNIPROT:P61081 GENECARDS:UBE2M REACTOME:66777 KEGG:9040 ATLASONC:GC_UBE2M WIKI:UBE2M ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 GENECARDS:UBE2N REACTOME:66781 KEGG:7334 ATLASONC:GC_UBE2N WIKI:UBE2N ubiquitin-conjugating enzyme E2O HUGO:UBE2O HGNC:29554 ENTREZ:63893 UNIPROT:Q9C0C9 GENECARDS:UBE2O REACTOME:253534 KEGG:63893 ATLASONC:GC_UBE2O WIKI:UBE2O ubiquitin-conjugating enzyme E2Q family member 1 HUGO:UBE2Q1 HGNC:15698 ENTREZ:55585 UNIPROT:Q7Z7E8 GENECARDS:UBE2Q1 REACTOME:253474 KEGG:55585 ATLASONC:GC_UBE2Q1 WIKI:UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 2 HUGO:UBE2Q2 HGNC:19248 ENTREZ:92912 UNIPROT:Q8WVN8 GENECARDS:UBE2Q2 REACTOME:253479 ATLASONC:GC_UBE2Q2 WIKI:UBE2Q2 ubiquitin-conjugating enzyme E2R 2 HUGO:UBE2R2 HGNC:19907 ENTREZ:54926 UNIPROT:Q712K3 GENECARDS:UBE2R2 REACTOME:253483 KEGG:54926 ATLASONC:GC_UBE2R2 WIKI:UBE2R2 ubiquitin-conjugating enzyme E2S HUGO:UBE2S HGNC:17895 ENTREZ:27338 UNIPROT:Q16763 GENECARDS:UBE2S REACTOME:66751 KEGG:27338 ATLASONC:GC_UBE2S WIKI:UBE2S ubiquitin-conjugating enzyme E2Z HUGO:UBE2Z HGNC:25847 ENTREZ:65264 UNIPROT:Q9H832 GENECARDS:UBE2Z REACTOME:253545 KEGG:65264 WIKI:UBE2Z Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C ubiquitin-conjugating enzyme E2D 1 HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 ubiquitin-conjugating enzyme E2E 1 HUGO:UBE2E1 HGNC:12477 ENTREZ:7324 UNIPROT:P51965 GENECARDS:UBE2E1 REACTOME:66739 KEGG:7324 ATLASONC:GC_UBE2E1 WIKI:UBE2E1 ubiquitin-conjugating enzyme E2E 2 HUGO:UBE2E2 HGNC:12478 ENTREZ:7325 UNIPROT:Q96LR5 GENECARDS:UBE2E2 REACTOME:155471 KEGG:7325 ATLASONC:GC_UBE2E2 WIKI:UBE2E2 ubiquitin-conjugating enzyme E2G 1 HUGO:UBE2G1 HGNC:12482 ENTREZ:7326 UNIPROT:P62253 GENECARDS:UBE2G1 REACTOME:66753 KEGG:7326 ATLASONC:GC_UBE2G1 WIKI:UBE2G1 ubiquitin-conjugating enzyme E2G 2 HUGO:UBE2G2 HGNC:12483 ENTREZ:7327 UNIPROT:P60604 GENECARDS:UBE2G2 REACTOME:66773 KEGG:7327 ATLASONC:GC_UBE2G2 WIKI:UBE2G2 ubiquitin-conjugating enzyme E2H HUGO:UBE2H HGNC:12484 ENTREZ:7328 UNIPROT:P62256 GENECARDS:UBE2H REACTOME:66759 KEGG:7328 ATLASONC:GC_UBE2H WIKI:UBE2H ubiquitin-conjugating enzyme E2I HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I ubiquitin-conjugating enzyme E2 J1 HUGO:UBE2J1 HGNC:17598 ENTREZ:51465 UNIPROT:Q9Y385 GENECARDS:UBE2J1 REACTOME:155484 KEGG:51465 ATLASONC:GC_UBE2J1 WIKI:UBE2J1 ubiquitin-conjugating enzyme E2 J2 HUGO:UBE2J2 HGNC:19268 ENTREZ:118424 UNIPROT:Q8N2K1 GENECARDS:UBE2J2 REACTOME:155486 KEGG:118424 WIKI:UBE2J2 ubiquitin-conjugating enzyme E2K HUGO:UBE2K HGNC:4914 ENTREZ:3093 UNIPROT:P61086 GENECARDS:UBE2K REACTOME:66723 KEGG:3093 WIKI:UBE2K ubiquitin-conjugating enzyme E2L 3 HUGO:UBE2L3 HGNC:12488 ENTREZ:7332 UNIPROT:P68036 GENECARDS:UBE2L3 REACTOME:66741 KEGG:7332 ATLASONC:GC_UBE2L3 WIKI:UBE2L3 ubiquitin-conjugating enzyme E2L 4 HUGO:UBE2L4 HGNC:12489 ENTREZ:7333 GENECARDS:UBE2L4 WIKI:UBE2L4 ubiquitin-conjugating enzyme E2L 6 HUGO:UBE2L6 HGNC:12490 ENTREZ:9246 UNIPROT:O14933 GENECARDS:UBE2L6 REACTOME:66745 KEGG:9246 ATLASONC:GC_UBE2L6 WIKI:UBE2L6 ubiquitin-conjugating enzyme E2M HUGO:UBE2M HGNC:12491 ENTREZ:9040 UNIPROT:P61081 GENECARDS:UBE2M REACTOME:66777 KEGG:9040 ATLASONC:GC_UBE2M WIKI:UBE2M ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 GENECARDS:UBE2N REACTOME:66781 KEGG:7334 ATLASONC:GC_UBE2N WIKI:UBE2N ubiquitin-conjugating enzyme E2O HUGO:UBE2O HGNC:29554 ENTREZ:63893 UNIPROT:Q9C0C9 GENECARDS:UBE2O REACTOME:253534 KEGG:63893 ATLASONC:GC_UBE2O WIKI:UBE2O ubiquitin-conjugating enzyme E2Q family member 1 HUGO:UBE2Q1 HGNC:15698 ENTREZ:55585 UNIPROT:Q7Z7E8 GENECARDS:UBE2Q1 REACTOME:253474 KEGG:55585 ATLASONC:GC_UBE2Q1 WIKI:UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 2 HUGO:UBE2Q2 HGNC:19248 ENTREZ:92912 UNIPROT:Q8WVN8 GENECARDS:UBE2Q2 REACTOME:253479 ATLASONC:GC_UBE2Q2 WIKI:UBE2Q2 ubiquitin-conjugating enzyme E2R 2 HUGO:UBE2R2 HGNC:19907 ENTREZ:54926 UNIPROT:Q712K3 GENECARDS:UBE2R2 REACTOME:253483 KEGG:54926 ATLASONC:GC_UBE2R2 WIKI:UBE2R2 ubiquitin-conjugating enzyme E2S HUGO:UBE2S HGNC:17895 ENTREZ:27338 UNIPROT:Q16763 GENECARDS:UBE2S REACTOME:66751 KEGG:27338 ATLASONC:GC_UBE2S WIKI:UBE2S ubiquitin-conjugating enzyme E2Z HUGO:UBE2Z HGNC:25847 ENTREZ:65264 UNIPROT:Q9H832 GENECARDS:UBE2Z REACTOME:253545 KEGG:65264 WIKI:UBE2Z Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> </notes> <label text="E2*"/> <clone/> <bbox w="80.0" h="40.0" x="18382.0" y="3955.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s141_shh1_shh2_sa128" compartmentRef="shh1_shh2_c3_shh1_shh2_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: HUGO:STK36 HGNC:17209 ENTREZ:27148 UNIPROT:Q9NRP7 GENECARDS:STK36 KEGG:27148 ATLASONC:GC_STK36 WIKI:STK36 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11960000 References_end</body> </html> </notes> <label text="FU*"/> <bbox w="80.0" h="40.0" x="18099.0" y="4415.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s22_shh1_shh2_sa21" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re7:(MAP:survival) PMID:12138125 s_shh2_re61:(MAP:survival) PMID:19996099 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 1 HUGO:GLI1 HGNC:4317 ENTREZ:2735 UNIPROT:P08151 GENECARDS:GLI1 KEGG:2735 ATLASONC:GLIID310ch12q13 WIKI:GLI1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI1"/> <bbox w="80.0" h="40.0" x="18275.375" y="3448.0"/> <glyph class="state variable" id="_c37fdc14-efaf-4852-8971-21323c45b53f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18270.375" y="3443.0"/> </glyph> <glyph class="state variable" id="_129ae526-74db-4be0-951d-1180ff2c37b9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18270.375" y="3483.0"/> </glyph> <glyph class="state variable" id="_396cfe32-86a6-44b5-854c-bf8f35c71810"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18350.375" y="3443.0"/> </glyph> <glyph class="state variable" id="_ca6a64fa-2775-43a1-a7ca-2e2e053e678a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18350.375" y="3483.0"/> </glyph> <glyph class="state variable" id="_0122fca7-4a8d-46b2-8294-3168f5aacc9e"> <state value="" variable="T374"/> <bbox w="30.0" h="10.0" x="18339.756" y="3483.0"/> </glyph> <glyph class="state variable" id="_07a0818f-b0b4-4e6a-bd65-80484c39ef90"> <state value="" variable="S640"/> <bbox w="30.0" h="10.0" x="18260.375" y="3482.7224"/> </glyph> <glyph class="state variable" id="_496b8e84-588f-4684-bb4d-c16ab07d38d1"> <state value="" variable="K518"/> <bbox w="30.0" h="10.0" x="18283.35" y="3483.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s25_shh1_shh2_sa18" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re7:(MAP:survival) PMID:12138125 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 1 HUGO:GLI1 HGNC:4317 ENTREZ:2735 UNIPROT:P08151 GENECARDS:GLI1 KEGG:2735 ATLASONC:GLIID310ch12q13 WIKI:GLI1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI1"/> <bbox w="80.0" h="40.0" x="18275.0" y="3346.0"/> <glyph class="state variable" id="_a86b145a-061e-4e60-8d4b-854566476ec7"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="18267.5" y="3341.0"/> </glyph> <glyph class="state variable" id="_b00267f1-f7f6-4b25-a551-15ac888e2747"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18270.0" y="3381.0"/> </glyph> <glyph class="state variable" id="_24c98c44-44bc-4d5a-9a91-b1a6a9df24d4"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="18347.5" y="3341.0"/> </glyph> <glyph class="state variable" id="_16e1a7eb-a344-4a2b-a84e-6afe35426357"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18350.0" y="3381.0"/> </glyph> <glyph class="state variable" id="_520bc38d-14aa-4df5-8cfc-1caf5cc075db"> <state value="" variable="T374"/> <bbox w="30.0" h="10.0" x="18339.38" y="3381.0"/> </glyph> <glyph class="state variable" id="_ecbe86dc-697b-48c8-9374-5c5184451725"> <state value="" variable="S640"/> <bbox w="30.0" h="10.0" x="18260.0" y="3380.7224"/> </glyph> <glyph class="state variable" id="_5caf44a9-fdb3-400d-8ab8-342d7a69cb0c"> <state value="" variable="K518"/> <bbox w="30.0" h="10.0" x="18282.975" y="3381.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s32_shh1_shh1_sa269" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 1 HUGO:GLI1 HGNC:4317 ENTREZ:2735 UNIPROT:P08151 GENECARDS:GLI1 KEGG:2735 ATLASONC:GLIID310ch12q13 WIKI:GLI1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI1"/> <bbox w="80.0" h="40.0" x="19256.5" y="2265.0"/> <glyph class="state variable" id="_1bc9db91-3bb0-49cb-b214-5bc96d0c6cab"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19251.5" y="2260.0"/> </glyph> <glyph class="state variable" id="_f90d0098-b4ae-4869-8597-314b0f8429d5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19251.5" y="2300.0"/> </glyph> <glyph class="state variable" id="_c21f0d69-93e6-47d8-8237-05fcd0bfcdd6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19331.5" y="2260.0"/> </glyph> <glyph class="state variable" id="_e109eef0-3782-49cf-92a6-699f2dd5ce52"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19331.5" y="2300.0"/> </glyph> <glyph class="state variable" id="_2f09c876-bba7-4f8d-98c2-ec5afc65d6f2"> <state value="" variable="T374"/> <bbox w="30.0" h="10.0" x="19320.88" y="2300.0"/> </glyph> <glyph class="state variable" id="_b9eef028-41fa-4156-8039-8eccb449ab57"> <state value="" variable="S640"/> <bbox w="30.0" h="10.0" x="19241.5" y="2299.7224"/> </glyph> <glyph class="state variable" id="_0200acfe-f9c9-486e-a5ea-771442236064"> <state value="" variable="K518"/> <bbox w="30.0" h="10.0" x="19264.475" y="2300.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s37_shh1_shh2_sa31" compartmentRef="shh1_shh2_c3_shh1_shh2_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re14:(MAP:survival) PMID:16293631 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 1 HUGO:GLI1 HGNC:4317 ENTREZ:2735 UNIPROT:P08151 GENECARDS:GLI1 KEGG:2735 ATLASONC:GLIID310ch12q13 WIKI:GLI1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI1"/> <bbox w="80.0" h="40.0" x="17987.5" y="3298.0"/> <glyph class="state variable" id="_54ee6f8a-7c01-44e4-a637-6f467f3f51f2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="17982.5" y="3293.0"/> </glyph> <glyph class="state variable" id="_734fc8bb-924f-4250-8c61-b674955b8738"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="17982.5" y="3333.0"/> </glyph> <glyph class="state variable" id="_cd0098b1-6c14-4934-b5c5-82c0855542e9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18062.5" y="3293.0"/> </glyph> <glyph class="state variable" id="_56162432-a401-41c8-9be0-c112524fbc9c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18062.5" y="3333.0"/> </glyph> <glyph class="state variable" id="_42724d78-53f2-4e90-b3f8-79c83cd81afa"> <state value="P" variable="T374"/> <bbox w="35.0" h="10.0" x="18049.38" y="3333.0"/> </glyph> <glyph class="state variable" id="_350eed90-5aab-4df0-9715-a71fb9ed4c2c"> <state value="" variable="S640"/> <bbox w="30.0" h="10.0" x="17972.5" y="3332.7224"/> </glyph> <glyph class="state variable" id="_f748690b-99a3-4929-93b6-aaa33e0e6ad3"> <state value="" variable="K518"/> <bbox w="30.0" h="10.0" x="17995.475" y="3333.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s101_shh1_shh2_sa91" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re61:(MAP:survival) PMID:19996099 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 1 HUGO:GLI1 HGNC:4317 ENTREZ:2735 UNIPROT:P08151 GENECARDS:GLI1 KEGG:2735 ATLASONC:GLIID310ch12q13 WIKI:GLI1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI1"/> <bbox w="80.0" h="40.0" x="18531.75" y="3544.0"/> <glyph class="state variable" id="_76815195-f313-47ec-b31f-e64963eb4ce6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18526.75" y="3539.0"/> </glyph> <glyph class="state variable" id="_1e08927a-58ac-4083-a734-d7f9206c9ead"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18526.75" y="3579.0"/> </glyph> <glyph class="state variable" id="_3aa56b40-4eef-4b50-a3a4-3f835e1697e2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18606.75" y="3539.0"/> </glyph> <glyph class="state variable" id="_dcff797c-eb56-4e83-9d37-25c71862b210"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18606.75" y="3579.0"/> </glyph> <glyph class="state variable" id="_d2c34f28-8602-48a3-bb8d-d8e1ec819980"> <state value="" variable="T374"/> <bbox w="30.0" h="10.0" x="18596.13" y="3579.0"/> </glyph> <glyph class="state variable" id="_e3d240af-82dd-4ddb-ae06-de640ebf0ed0"> <state value="P" variable="S640"/> <bbox w="35.0" h="10.0" x="18514.25" y="3578.7224"/> </glyph> <glyph class="state variable" id="_659a507f-bb91-40e4-9e50-e7e2d690f02c"> <state value="" variable="K518"/> <bbox w="30.0" h="10.0" x="18539.725" y="3579.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s116_shh1_shh2_sa103" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 1 HUGO:GLI1 HGNC:4317 ENTREZ:2735 UNIPROT:P08151 GENECARDS:GLI1 KEGG:2735 ATLASONC:GLIID310ch12q13 WIKI:GLI1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI1"/> <bbox w="80.0" h="40.0" x="18274.375" y="3877.5"/> <glyph class="state variable" id="_b8142052-365c-4477-8243-bd41c2f3553c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18269.375" y="3872.5"/> </glyph> <glyph class="state variable" id="_88c0f52c-2c72-413a-8e6f-dbfc414d5d6a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18269.375" y="3912.5"/> </glyph> <glyph class="state variable" id="_90fc419f-3a29-4977-8785-41d74c1d2774"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18349.375" y="3872.5"/> </glyph> <glyph class="state variable" id="_6df8cd7f-a9ad-42b9-9410-df3b6097b5e5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18349.375" y="3912.5"/> </glyph> <glyph class="state variable" id="_aa7f20fc-3efb-4ae2-bbda-28c58f605fcb"> <state value="" variable="T374"/> <bbox w="30.0" h="10.0" x="18338.756" y="3912.5"/> </glyph> <glyph class="state variable" id="_5b990e40-b211-43a4-a49c-13c3375468be"> <state value="" variable="S640"/> <bbox w="30.0" h="10.0" x="18259.375" y="3912.2224"/> </glyph> <glyph class="state variable" id="_9e64b08e-c90f-41de-998c-004f647e258f"> <state value="Ac" variable="K518"/> <bbox w="40.0" h="10.0" x="18277.35" y="3912.5"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s107_shh1_shh2_sa96" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re63:(MAP:survival) PMID:19996099 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 2 HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Glioma-associated oncogene family zinc finger PMID:18497536 PMID:17845852 PMID:11001584 References_end</body> </html> </notes> <label text="GLI2-185*"/> <bbox w="165.0" h="45.0" x="19486.0" y="3181.56"/> <glyph class="state variable" id="_b2cd1a04-8d17-4e7b-b003-81cff2a63083"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19536.232" y="3176.56"/> </glyph> <glyph class="state variable" id="_1610347c-04ca-4d90-b255-f96fac96ba22"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="19575.229" y="3176.56"/> </glyph> <glyph class="state variable" id="_c7898215-56e6-4f18-b49a-1bca1d614b13"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19584.355" y="3221.56"/> </glyph> <glyph class="state variable" id="_3203b681-51f8-4029-8037-9e64025ede4f"> <state value="" variable="S801"/> <bbox w="30.0" h="10.0" x="19539.406" y="3176.56"/> </glyph> <glyph class="state variable" id="_f1656826-d6a1-4f74-8fdd-fd127dfb003c"> <state value="" variable="K757"/> <bbox w="30.0" h="10.0" x="19471.0" y="3190.55"/> </glyph> <glyph class="state variable" id="_7ad41996-b9c5-4c62-86d5-dbdd02a36add"> <state value="P" variable="S956"/> <bbox w="35.0" h="10.0" x="19468.5" y="3221.2476"/> </glyph> <glyph class="state variable" id="_3564b2fb-3796-4647-9034-2c9c6a3a5f3a"> <state value="" variable="S817"/> <bbox w="30.0" h="10.0" x="19634.725" y="3221.56"/> </glyph> <glyph class="state variable" id="_72ef2139-088e-4795-ba68-d2ce05c43f27"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19563.5" y="3176.56"/> </glyph> <glyph class="state variable" id="_e9375de3-5f5d-4229-bb65-ddcda9bbd30b"> <state value="" variable="S847"/> <bbox w="30.0" h="10.0" x="19522.22" y="3221.56"/> </glyph> <glyph class="state variable" id="_62088454-d27e-491f-b682-5d64ddd96788"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="19471.0" y="3199.0242"/> </glyph> <glyph class="state variable" id="_e1eae496-4291-4630-8d47-d2a5193ccbcf"> <state value="" variable="S789"/> <bbox w="30.0" h="10.0" x="19471.0" y="3190.0317"/> </glyph> <glyph class="state variable" id="_237b58e2-8057-4e36-9464-329eeb007f66"> <state value="" variable="S1011"/> <bbox w="35.0" h="10.0" x="19468.5" y="3206.9788"/> </glyph> <glyph class="state variable" id="_c64e8dab-6bef-4c57-a3ff-19cd9d3b358f"> <state value="" variable="S805"/> <bbox w="30.0" h="10.0" x="19574.635" y="3176.56"/> </glyph> <glyph class="state variable" id="_a6ebfa08-46e6-4527-bbe6-cc738b4adb89"> <state value="" variable="S820"/> <bbox w="30.0" h="10.0" x="19599.389" y="3221.56"/> </glyph> <glyph class="state variable" id="_e912704b-e2ed-4fb8-9203-f303fb3ec32d"> <state value="" variable="S813"/> <bbox w="30.0" h="10.0" x="19636.0" y="3199.1318"/> </glyph> <glyph class="state variable" id="_e8a3a682-c429-413b-9bed-429c7fa424de"> <state value="" variable="S850"/> <bbox w="30.0" h="10.0" x="19471.0" y="3220.3772"/> </glyph> <glyph class="state variable" id="_a750505d-295d-4c47-bda6-21ce8f25c63e"> <state value="" variable="S844"/> <bbox w="30.0" h="10.0" x="19548.346" y="3221.56"/> </glyph> <glyph class="state variable" id="_066fbe91-9aea-46ef-93cd-f24ca74f3ea7"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="19472.016" y="3176.56"/> </glyph> <glyph class="state variable" id="_2e34914a-5b4b-4419-9294-60fbec0f41bb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19584.355" y="3221.56"/> </glyph> <glyph class="state variable" id="_9b97817c-b590-45b5-ad89-b4eaaa96e155"> <state value="" variable="S808"/> <bbox w="30.0" h="10.0" x="19635.244" y="3176.56"/> </glyph> <glyph class="state variable" id="_7e68c8a6-20e6-4d50-9f88-9c323a909067"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19524.74" y="3176.56"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s108_shh1_shh2_sa36" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re72:(MAP:survival) PMID:20081843 s_shh2_re63:(MAP:survival) PMID:19996099 s_shh2_re115:(MAP:survival) PMID:20463034 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 2 HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Glioma-associated oncogene family zinc finger PMID:18497536 PMID:17845852 PMID:11001584 References_end</body> </html> </notes> <label text="GLI2-185*"/> <bbox w="165.0" h="45.0" x="19293.0" y="3008.6802"/> <glyph class="state variable" id="_39118a5b-aa83-4a95-a25e-f14ddce3ff63"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19343.232" y="3003.6802"/> </glyph> <glyph class="state variable" id="_9b50b56d-3ef7-4106-b472-62003f65d353"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="19382.229" y="3003.6802"/> </glyph> <glyph class="state variable" id="_2fd27f13-a532-4d5e-bea6-1ea4ee6391ae"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19391.355" y="3048.6802"/> </glyph> <glyph class="state variable" id="_62dc22e4-5a1c-4b1c-aaaf-31245023f6d6"> <state value="" variable="S801"/> <bbox w="30.0" h="10.0" x="19346.406" y="3003.6802"/> </glyph> <glyph class="state variable" id="_bb941c17-0b22-45fa-b4f4-8d9512d7a7bd"> <state value="" variable="K757"/> <bbox w="30.0" h="10.0" x="19278.0" y="3017.6702"/> </glyph> <glyph class="state variable" id="_5855c80c-f39d-4a23-8762-4fe698a15b59"> <state value="" variable="S956"/> <bbox w="30.0" h="10.0" x="19278.0" y="3048.3677"/> </glyph> <glyph class="state variable" id="_c8236427-149b-4826-ad2d-025a27e63ef1"> <state value="" variable="S817"/> <bbox w="30.0" h="10.0" x="19441.725" y="3048.6802"/> </glyph> <glyph class="state variable" id="_6adde25f-959f-42bc-bbb8-09933688504b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19370.5" y="3003.6802"/> </glyph> <glyph class="state variable" id="_2042b64f-6318-41d6-ab9d-6cd34a014d5b"> <state value="" variable="S847"/> <bbox w="30.0" h="10.0" x="19329.22" y="3048.6802"/> </glyph> <glyph class="state variable" id="_b98cf012-20b8-48f9-a6a7-5e732a37f585"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="19278.0" y="3026.1443"/> </glyph> <glyph class="state variable" id="_4fc04e13-1450-4743-8a58-3671c4929931"> <state value="" variable="S789"/> <bbox w="30.0" h="10.0" x="19278.0" y="3017.1519"/> </glyph> <glyph class="state variable" id="_f9d5f645-6ea3-4704-b78d-1b1883f0139e"> <state value="" variable="S1011"/> <bbox w="35.0" h="10.0" x="19275.5" y="3034.0989"/> </glyph> <glyph class="state variable" id="_44b881f6-9d23-4405-bc59-3174f730a5f6"> <state value="" variable="S805"/> <bbox w="30.0" h="10.0" x="19381.635" y="3003.6802"/> </glyph> <glyph class="state variable" id="_df532f28-bda3-4698-b08d-eb411671c273"> <state value="" variable="S820"/> <bbox w="30.0" h="10.0" x="19406.389" y="3048.6802"/> </glyph> <glyph class="state variable" id="_bf138438-4cf0-450b-9c0d-e0448e866594"> <state value="" variable="S813"/> <bbox w="30.0" h="10.0" x="19443.0" y="3026.252"/> </glyph> <glyph class="state variable" id="_8c748bb3-e768-418e-8d7b-3df0bff79097"> <state value="" variable="S850"/> <bbox w="30.0" h="10.0" x="19278.0" y="3047.4973"/> </glyph> <glyph class="state variable" id="_24b6506e-43fe-4f40-8690-8c5743af7b34"> <state value="" variable="S844"/> <bbox w="30.0" h="10.0" x="19355.346" y="3048.6802"/> </glyph> <glyph class="state variable" id="_751a2e45-e9d3-4305-954e-682d57298265"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="19279.016" y="3003.6802"/> </glyph> <glyph class="state variable" id="_32bce452-1063-4c66-9ebb-5850bd34382c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19391.355" y="3048.6802"/> </glyph> <glyph class="state variable" id="_1da11cd1-b581-4d9e-9deb-5954229410cf"> <state value="" variable="S808"/> <bbox w="30.0" h="10.0" x="19442.244" y="3003.6802"/> </glyph> <glyph class="state variable" id="_9e64f8e9-02a9-4dbe-950b-db7d416d9dd8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19331.74" y="3003.6802"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s124_shh1_shh2_sa112" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re71:(MAP:survival) PMID:20081843 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 2 HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Glioma-associated oncogene family zinc finger PMID:18497536 PMID:17845852 PMID:11001584 References_end</body> </html> </notes> <label text="GLI2-185*"/> <bbox w="165.0" h="45.0" x="19293.75" y="3175.0"/> <glyph class="state variable" id="_82008c4f-44f0-4bdd-a1a9-a68feb5c2d1f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19343.982" y="3170.0"/> </glyph> <glyph class="state variable" id="_3b62cd12-19f3-40a0-873f-984c94ee3f94"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="19382.979" y="3170.0"/> </glyph> <glyph class="state variable" id="_672b3780-cacd-4c2e-b681-0fe595d347f4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19392.105" y="3215.0"/> </glyph> <glyph class="state variable" id="_a4879787-8943-47a2-b940-21446aa8e4f1"> <state value="" variable="S801"/> <bbox w="30.0" h="10.0" x="19347.156" y="3170.0"/> </glyph> <glyph class="state variable" id="_53f24681-3c7c-448a-aa9c-86567168ce17"> <state value="Ac" variable="K757"/> <bbox w="40.0" h="10.0" x="19273.75" y="3183.99"/> </glyph> <glyph class="state variable" id="_cc5cca0a-bc0e-441c-95b7-c43e3a7f2dec"> <state value="" variable="S956"/> <bbox w="30.0" h="10.0" x="19278.75" y="3214.6875"/> </glyph> <glyph class="state variable" id="_6328b6bf-082f-48a2-9b78-7624167f37d2"> <state value="" variable="S817"/> <bbox w="30.0" h="10.0" x="19442.475" y="3215.0"/> </glyph> <glyph class="state variable" id="_a5607944-1704-41a7-9a08-bbfa2d51ad4a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19371.25" y="3170.0"/> </glyph> <glyph class="state variable" id="_174a7f43-43b9-42a4-8423-aa9339d10849"> <state value="" variable="S847"/> <bbox w="30.0" h="10.0" x="19329.97" y="3215.0"/> </glyph> <glyph class="state variable" id="_a8e9527c-baeb-4da7-819b-15dc4d0df91d"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="19278.75" y="3192.464"/> </glyph> <glyph class="state variable" id="_747b32ef-92f7-4e5d-aaed-2e1b58a3a2f1"> <state value="" variable="S789"/> <bbox w="30.0" h="10.0" x="19278.75" y="3183.4717"/> </glyph> <glyph class="state variable" id="_0c5f2350-134f-49c5-9a82-0bfe63af6217"> <state value="" variable="S1011"/> <bbox w="35.0" h="10.0" x="19276.25" y="3200.4187"/> </glyph> <glyph class="state variable" id="_0099c356-7a5c-4355-9871-bb4527bd6429"> <state value="" variable="S805"/> <bbox w="30.0" h="10.0" x="19382.385" y="3170.0"/> </glyph> <glyph class="state variable" id="_d0027081-a71b-4fbb-a2b2-a2e66e92f829"> <state value="" variable="S820"/> <bbox w="30.0" h="10.0" x="19407.139" y="3215.0"/> </glyph> <glyph class="state variable" id="_c18e78c6-8c2f-4db4-9357-5058c7f55d61"> <state value="" variable="S813"/> <bbox w="30.0" h="10.0" x="19443.75" y="3192.5718"/> </glyph> <glyph class="state variable" id="_6b7c3445-c6ff-4732-b9b4-fe1af73554c3"> <state value="" variable="S850"/> <bbox w="30.0" h="10.0" x="19278.75" y="3213.8171"/> </glyph> <glyph class="state variable" id="_887db296-aea3-4a65-b6f5-e9e1203b64ce"> <state value="" variable="S844"/> <bbox w="30.0" h="10.0" x="19356.096" y="3215.0"/> </glyph> <glyph class="state variable" id="_1997ff95-8420-4a64-8b4f-8866285eb7fc"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="19279.766" y="3170.0"/> </glyph> <glyph class="state variable" id="_375dc045-4cbe-48ec-bffb-446d1517dd9d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19392.105" y="3215.0"/> </glyph> <glyph class="state variable" id="_25f8994c-bd50-4c3b-b36c-e63a5087cebc"> <state value="" variable="S808"/> <bbox w="30.0" h="10.0" x="19442.994" y="3170.0"/> </glyph> <glyph class="state variable" id="_c33340db-f869-4639-86df-9b5e2f6067a3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19332.49" y="3170.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s209_shh1_shh2_sa185" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re115:(MAP:survival) PMID:20463034 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 2 HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Glioma-associated oncogene family zinc finger PMID:18497536 PMID:17845852 PMID:11001584 References_end</body> </html> </notes> <label text="GLI2-185*"/> <bbox w="165.0" h="45.0" x="19530.75" y="3079.0"/> <glyph class="state variable" id="_ae4e59b7-d495-4b01-aef8-fc431309801e"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="19575.982" y="3074.0"/> </glyph> <glyph class="state variable" id="_c0d467a2-9b3e-4c6a-822c-7c8a3a993f3a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="19619.979" y="3074.0"/> </glyph> <glyph class="state variable" id="_ba2a039d-39f5-42b3-a981-f9970840269f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19629.105" y="3119.0"/> </glyph> <glyph class="state variable" id="_87ae139d-31e5-4061-a55b-ed4f115dac94"> <state value="" variable="S801"/> <bbox w="30.0" h="10.0" x="19584.156" y="3074.0"/> </glyph> <glyph class="state variable" id="_38dc5cf7-bcb2-43ef-9ab9-93a93bc9af8b"> <state value="" variable="K757"/> <bbox w="30.0" h="10.0" x="19515.75" y="3087.99"/> </glyph> <glyph class="state variable" id="_ea328824-435f-469c-8f67-c3c30a9577eb"> <state value="" variable="S956"/> <bbox w="30.0" h="10.0" x="19515.75" y="3118.6875"/> </glyph> <glyph class="state variable" id="_d1b2ce54-9002-4164-9eb0-c270737c7f39"> <state value="" variable="S817"/> <bbox w="30.0" h="10.0" x="19679.475" y="3119.0"/> </glyph> <glyph class="state variable" id="_4b1e8a33-be3d-4680-903e-607a12e4052c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19608.25" y="3074.0"/> </glyph> <glyph class="state variable" id="_d721545a-b25b-4a2a-912b-9f779db89c85"> <state value="" variable="S847"/> <bbox w="30.0" h="10.0" x="19566.97" y="3119.0"/> </glyph> <glyph class="state variable" id="_8fe42d88-14d4-449f-b348-4f0e4a908ad0"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="19515.75" y="3096.464"/> </glyph> <glyph class="state variable" id="_1d4560e0-396f-4068-a4ea-8961c7475388"> <state value="" variable="S789"/> <bbox w="30.0" h="10.0" x="19515.75" y="3087.4717"/> </glyph> <glyph class="state variable" id="_0d153762-be13-47e3-99c7-3fd5e1db8c42"> <state value="" variable="S1011"/> <bbox w="35.0" h="10.0" x="19513.25" y="3104.4187"/> </glyph> <glyph class="state variable" id="_f2e968e8-05ce-459b-8d89-2ab6db7d1a4b"> <state value="" variable="S805"/> <bbox w="30.0" h="10.0" x="19619.385" y="3074.0"/> </glyph> <glyph class="state variable" id="_8e4261af-f331-4328-b805-25806536ae21"> <state value="" variable="S820"/> <bbox w="30.0" h="10.0" x="19644.139" y="3119.0"/> </glyph> <glyph class="state variable" id="_ff929d99-ee9b-4a2f-b9f3-85bb9a1f4a57"> <state value="" variable="S813"/> <bbox w="30.0" h="10.0" x="19680.75" y="3096.5718"/> </glyph> <glyph class="state variable" id="_20282099-892a-410e-bc93-b2e3f0b676b9"> <state value="" variable="S850"/> <bbox w="30.0" h="10.0" x="19515.75" y="3117.8171"/> </glyph> <glyph class="state variable" id="_a549b784-5e8a-4fb5-b446-81e98c94a677"> <state value="" variable="S844"/> <bbox w="30.0" h="10.0" x="19593.096" y="3119.0"/> </glyph> <glyph class="state variable" id="_10a3b12f-6e76-44d3-bc4f-b747a6125831"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="19516.766" y="3074.0"/> </glyph> <glyph class="state variable" id="_5539dde1-9f66-402d-9835-783c3458e397"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19629.105" y="3119.0"/> </glyph> <glyph class="state variable" id="_b528e7e2-8228-4a85-89a6-44bed727132c"> <state value="" variable="S808"/> <bbox w="30.0" h="10.0" x="19679.994" y="3074.0"/> </glyph> <glyph class="state variable" id="_1ae6a1c5-f26f-4d7d-b3a2-460d5916a875"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19569.49" y="3074.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s9_shh1_shh2_sa6" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re1:(MAP:survival) PMID:20360384 PMID:16740475 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 3 HUGO:GLI3 HGNC:4319 ENTREZ:2737 UNIPROT:P10071 GENECARDS:GLI3 KEGG:2737 ATLASONC:GC_GLI3 WIKI:GLI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI3-190*"/> <bbox w="165.0" h="41.0" x="19926.875" y="3320.0"/> <glyph class="state variable" id="_b3a5004e-e413-4a6c-ab64-bd4280ae7e1b"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="19948.885" y="3315.0"/> </glyph> <glyph class="state variable" id="_07823b64-afc3-441e-8511-395423292f27"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="19968.396" y="3315.0"/> </glyph> <glyph class="state variable" id="_432280db-3c9f-45d4-b340-f9a0f95c7160"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="19981.86" y="3315.0"/> </glyph> <glyph class="state variable" id="_9f6c0270-0d77-49b7-b36b-f38da389c562"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="20020.23" y="3356.0"/> </glyph> <glyph class="state variable" id="_09144e63-5ff1-420a-9861-0e9d9257067d"> <state value="" variable="S860"/> <bbox w="30.0" h="10.0" x="20012.027" y="3315.0"/> </glyph> <glyph class="state variable" id="_ada96ad1-754e-490c-b32d-83c76da65d0c"> <state value="" variable="S907"/> <bbox w="30.0" h="10.0" x="19959.262" y="3356.0"/> </glyph> <glyph class="state variable" id="_da3df946-ab9f-4524-a8dc-e593c672e302"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19953.885" y="3315.0"/> </glyph> <glyph class="state variable" id="_11492bea-a8d8-4a8c-b70d-95b53c85f8ec"> <state value="" variable="S873"/> <bbox w="30.0" h="10.0" x="20076.875" y="3335.5652"/> </glyph> <glyph class="state variable" id="_331119c3-401c-4818-89e7-d1cd83023cc8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19973.396" y="3315.0"/> </glyph> <glyph class="state variable" id="_ef734a52-cd3f-49b7-940a-ef40361e3713"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="19912.89" y="3315.0"/> </glyph> <glyph class="state variable" id="_12f07d1c-fb68-4504-af64-41b6aababad5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19986.86" y="3315.0"/> </glyph> <glyph class="state variable" id="_dbfd0ea9-6ea9-460c-b6df-d9a3d88668f6"> <state value="" variable="S868"/> <bbox w="30.0" h="10.0" x="20069.826" y="3315.0"/> </glyph> <glyph class="state variable" id="_138d3f82-7960-46c6-a536-c5c0d1a2d4df"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20025.23" y="3356.0"/> </glyph> <glyph class="state variable" id="_c5522c7e-1e9d-448c-a697-8ce161c85b71"> <state value="" variable="S877"/> <bbox w="30.0" h="10.0" x="20075.6" y="3356.0"/> </glyph> <glyph class="state variable" id="_c39084f3-567d-4a33-a143-31f24658f822"> <state value="" variable="S880"/> <bbox w="30.0" h="10.0" x="20032.975" y="3356.0"/> </glyph> <glyph class="state variable" id="_27b538ae-08c9-441e-b1c7-63e51932e9f0"> <state value="" variable="S903"/> <bbox w="30.0" h="10.0" x="19995.828" y="3356.0"/> </glyph> <glyph class="state variable" id="_7f5a9ca6-cc39-4ec7-8c81-aa126041125f"> <state value="" variable="S910"/> <bbox w="30.0" h="10.0" x="19912.37" y="3356.0"/> </glyph> <glyph class="state variable" id="_27316eda-e437-403f-a8d7-a87ce3a0c87c"> <state value="" variable="S852"/> <bbox w="30.0" h="10.0" x="19992.791" y="3315.0"/> </glyph> <glyph class="state variable" id="_7e707e1f-1f7b-46fc-88a9-4696db5193d3"> <state value="" variable="S1006"/> <bbox w="35.0" h="10.0" x="19909.375" y="3330.0115"/> </glyph> <glyph class="state variable" id="_ac3435e5-07ab-49dc-b751-dae2f08e6764"> <state value="" variable="S865"/> <bbox w="30.0" h="10.0" x="20029.332" y="3315.0"/> </glyph> <glyph class="state variable" id="_9bcbef43-9e36-47fa-85eb-e9569377522b"> <state value="" variable="S980"/> <bbox w="30.0" h="10.0" x="19911.875" y="3337.7312"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s100_shh1_shh2_sa2" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re1:(MAP:survival) PMID:20360384 PMID:16740475 s_shh2_re64:(MAP:survival) PMID:19996099 s_shh2_re118:(MAP:survival) PMID:17000779 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 3 HUGO:GLI3 HGNC:4319 ENTREZ:2737 UNIPROT:P10071 GENECARDS:GLI3 KEGG:2737 ATLASONC:GC_GLI3 WIKI:GLI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI3-190*"/> <bbox w="165.0" h="41.0" x="19927.875" y="3028.0"/> <glyph class="state variable" id="_12a867ea-9302-4863-8571-8e285b5f23a1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19954.885" y="3023.0"/> </glyph> <glyph class="state variable" id="_e51117e8-339a-471c-b8d2-2236cee22173"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19974.396" y="3023.0"/> </glyph> <glyph class="state variable" id="_f928c2cc-ad12-436e-9238-09abd6a0b041"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19987.86" y="3023.0"/> </glyph> <glyph class="state variable" id="_c5937580-3a77-4c4f-abf6-7447138d715d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20026.23" y="3064.0"/> </glyph> <glyph class="state variable" id="_248c3f7f-3728-4d7d-8986-596f6bb2e8aa"> <state value="" variable="S860"/> <bbox w="30.0" h="10.0" x="20013.027" y="3023.0"/> </glyph> <glyph class="state variable" id="_1ab20101-8a1c-49a2-bf9a-7d56132d4738"> <state value="" variable="S907"/> <bbox w="30.0" h="10.0" x="19960.262" y="3064.0"/> </glyph> <glyph class="state variable" id="_c1abe0e1-e3e1-4ee0-aaae-b3fc07a6fc1e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19954.885" y="3023.0"/> </glyph> <glyph class="state variable" id="_2c23ed61-afc5-4405-8114-160de2d703fd"> <state value="" variable="S873"/> <bbox w="30.0" h="10.0" x="20077.875" y="3043.5652"/> </glyph> <glyph class="state variable" id="_bc114e2f-0d1d-4c5c-9866-b66d06eb4d8f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19974.396" y="3023.0"/> </glyph> <glyph class="state variable" id="_025b6b22-262d-43c4-b488-57d679498e9e"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="19913.89" y="3023.0"/> </glyph> <glyph class="state variable" id="_75684514-8b62-4dd4-97ee-50db4a389032"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19987.86" y="3023.0"/> </glyph> <glyph class="state variable" id="_7983cd02-4791-43da-a88a-6aad276cdca0"> <state value="" variable="S868"/> <bbox w="30.0" h="10.0" x="20070.826" y="3023.0"/> </glyph> <glyph class="state variable" id="_75bb5ad9-dbf1-47ce-a025-1512316a9e69"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20026.23" y="3064.0"/> </glyph> <glyph class="state variable" id="_2ba4f02e-b645-4f42-ac6c-e57844e0f3ea"> <state value="" variable="S877"/> <bbox w="30.0" h="10.0" x="20076.6" y="3064.0"/> </glyph> <glyph class="state variable" id="_9c42d632-0236-447e-9777-6cf6b65a8eab"> <state value="" variable="S880"/> <bbox w="30.0" h="10.0" x="20033.975" y="3064.0"/> </glyph> <glyph class="state variable" id="_1cd45f48-db18-495a-b79e-524dbb137f2a"> <state value="" variable="S903"/> <bbox w="30.0" h="10.0" x="19996.828" y="3064.0"/> </glyph> <glyph class="state variable" id="_0045ec47-7fca-4a94-a4d5-a58dd9b0ae9c"> <state value="" variable="S910"/> <bbox w="30.0" h="10.0" x="19913.37" y="3064.0"/> </glyph> <glyph class="state variable" id="_13067e62-102b-4476-bf80-5817b6e8164a"> <state value="" variable="S852"/> <bbox w="30.0" h="10.0" x="19993.791" y="3023.0"/> </glyph> <glyph class="state variable" id="_65001096-f6cc-43fc-89e1-c19dbc557a30"> <state value="" variable="S1006"/> <bbox w="35.0" h="10.0" x="19910.375" y="3038.0115"/> </glyph> <glyph class="state variable" id="_5c132b5c-05f4-4955-be5d-d7c19ea4280c"> <state value="" variable="S865"/> <bbox w="30.0" h="10.0" x="20030.332" y="3023.0"/> </glyph> <glyph class="state variable" id="_bfd42afe-c8a6-46e3-b2c7-a8cc0a92ff54"> <state value="" variable="S980"/> <bbox w="30.0" h="10.0" x="19912.875" y="3045.7312"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s109_shh1_shh2_sa98" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re64:(MAP:survival) PMID:19996099 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 3 HUGO:GLI3 HGNC:4319 ENTREZ:2737 UNIPROT:P10071 GENECARDS:GLI3 KEGG:2737 ATLASONC:GC_GLI3 WIKI:GLI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI3-190*"/> <bbox w="165.0" h="41.0" x="19835.75" y="3469.715"/> <glyph class="state variable" id="_7f0ea979-5e51-46c1-82d6-6a17d716c71e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19862.76" y="3464.715"/> </glyph> <glyph class="state variable" id="_d9d650d2-cbdc-41d5-9e79-077d04497507"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19882.271" y="3464.715"/> </glyph> <glyph class="state variable" id="_3156fa55-d424-45e4-a441-0c8fc8442cc4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19895.734" y="3464.715"/> </glyph> <glyph class="state variable" id="_455a2b51-2195-4024-b6f7-59af1d455f07"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19934.105" y="3505.715"/> </glyph> <glyph class="state variable" id="_f87a08b1-6a06-4e88-af0c-30eaf01c27bb"> <state value="" variable="S860"/> <bbox w="30.0" h="10.0" x="19920.902" y="3464.715"/> </glyph> <glyph class="state variable" id="_9064ee2d-5b66-4204-80ff-fc1b0e2b38f6"> <state value="" variable="S907"/> <bbox w="30.0" h="10.0" x="19868.137" y="3505.715"/> </glyph> <glyph class="state variable" id="_dd7c58dd-516f-43aa-b05d-47a698744795"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19862.76" y="3464.715"/> </glyph> <glyph class="state variable" id="_abae3313-8595-4bae-a3b1-208faf701fc3"> <state value="" variable="S873"/> <bbox w="30.0" h="10.0" x="19985.75" y="3485.2803"/> </glyph> <glyph class="state variable" id="_1948fd44-988b-4b91-9118-55af91522fee"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19882.271" y="3464.715"/> </glyph> <glyph class="state variable" id="_6c3cd00f-e7f0-49cd-91e9-b5347dbb040f"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="19821.766" y="3464.715"/> </glyph> <glyph class="state variable" id="_90a0344c-f93e-437e-8d21-135660c5d034"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19895.734" y="3464.715"/> </glyph> <glyph class="state variable" id="_3493066a-6ef6-4587-a9f4-076611a648b9"> <state value="" variable="S868"/> <bbox w="30.0" h="10.0" x="19978.701" y="3464.715"/> </glyph> <glyph class="state variable" id="_42f253da-634e-4a4a-8b16-1dd1a9b16867"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19934.105" y="3505.715"/> </glyph> <glyph class="state variable" id="_c7d71e60-518b-45c5-9355-6ea975b746ec"> <state value="" variable="S877"/> <bbox w="30.0" h="10.0" x="19984.475" y="3505.715"/> </glyph> <glyph class="state variable" id="_96d90a1d-3d58-4211-bf62-48b80de600a4"> <state value="" variable="S880"/> <bbox w="30.0" h="10.0" x="19941.85" y="3505.715"/> </glyph> <glyph class="state variable" id="_65d4360d-4b5b-4f15-9381-e0801bcb2d42"> <state value="" variable="S903"/> <bbox w="30.0" h="10.0" x="19904.703" y="3505.715"/> </glyph> <glyph class="state variable" id="_a81f8924-c3c1-4e92-ab74-cbb7e216d38f"> <state value="" variable="S910"/> <bbox w="30.0" h="10.0" x="19821.244" y="3505.715"/> </glyph> <glyph class="state variable" id="_ca7788a5-2fed-4e54-b3a2-17cb293e5e84"> <state value="" variable="S852"/> <bbox w="30.0" h="10.0" x="19901.666" y="3464.715"/> </glyph> <glyph class="state variable" id="_b2ad038f-a9a8-4d52-9931-69910c267bb6"> <state value="" variable="S1006"/> <bbox w="35.0" h="10.0" x="19818.25" y="3479.7266"/> </glyph> <glyph class="state variable" id="_83e3c579-56ba-4173-a0de-5a6d0072943f"> <state value="" variable="S865"/> <bbox w="30.0" h="10.0" x="19938.207" y="3464.715"/> </glyph> <glyph class="state variable" id="_0a7862f9-a925-4c1b-bf93-b3ba72ee648b"> <state value="" variable="S980"/> <bbox w="30.0" h="10.0" x="19820.75" y="3487.4463"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s13_shh1_shh2_sa10" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re3:(MAP:survival) PMID:12435627 PMID:19032343 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 3 HUGO:GLI3 HGNC:4319 ENTREZ:2737 UNIPROT:P10071 GENECARDS:GLI3 KEGG:2737 ATLASONC:GC_GLI3 WIKI:GLI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI3-83TRUNC*"/> <bbox w="80.0" h="40.0" x="18276.0" y="3146.75"/> <glyph class="unit of information" id="_7aae1835-76fc-4e6b-93d3-ae2915cecb74"> <label text="truncated"/> <bbox w="50.0" h="10.0" x="18291.0" y="3141.75"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s117_shh1_shh2_sa104" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re71:(MAP:survival) PMID:20081843 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Histone acetyl transferase 1 HUGO:HAT1 HGNC:4821 ENTREZ:8520 UNIPROT:O14929 GENECARDS:HAT1 KEGG:8520 ATLASONC:GC_HAT1 WIKI:HAT1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21234400 References_end</body> </html> </notes> <label text="HAT*"/> <bbox w="80.0" h="40.0" x="18394.0" y="3841.997"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s118_shh1_shh2_sa105" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re72:(MAP:survival) PMID:20081843 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Histone deacetylase 1 HUGO:HDAC1 HGNC:4852 ENTREZ:3065 UNIPROT:Q13547 GENECARDS:HDAC1 REACTOME:56408 KEGG:3065 ATLASONC:GC_HDAC1 WIKI:HDAC1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:cellcycle / MODULE:E2F1 MAP:cellcycle / MODULE:E2F4 MAP:cellcycle / MODULE:RB MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21234400 References_end</body> </html> </notes> <label text="HDAC1"/> <bbox w="80.0" h="40.0" x="18506.0" y="3841.997"/> <glyph class="state variable" id="_726cb8c5-5e4d-4a97-838c-10e9680c2d08"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18501.0" y="3876.997"/> </glyph> <glyph class="state variable" id="_0f322c68-a8de-4f74-ae0f-857e501f0ef6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18581.0" y="3876.997"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s122_shh1_shh2_sa106" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Histone deacetylase 1 HUGO:HDAC1 HGNC:4852 ENTREZ:3065 UNIPROT:Q13547 GENECARDS:HDAC1 REACTOME:56408 KEGG:3065 ATLASONC:GC_HDAC1 WIKI:HDAC1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:cellcycle / MODULE:E2F1 MAP:cellcycle / MODULE:E2F4 MAP:cellcycle / MODULE:RB MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21234400 References_end</body> </html> </notes> <label text="HDAC1"/> <bbox w="80.0" h="40.0" x="18505.5" y="4002.0"/> <glyph class="state variable" id="_41cdeec2-921c-40a3-9902-89e1a5a038f8"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="18495.5" y="4037.0"/> </glyph> <glyph class="state variable" id="_a0c4e9c3-6bab-4337-b0f5-295be5f6efdd"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="18575.5" y="4037.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s242_shh1_shh2_sa210" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re3:(MAP:survival) PMID:12435627 PMID:19032343 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Histone deacetylase 3 HUGO:HDAC3 HGNC:4854 ENTREZ:8841 UNIPROT:O15379 GENECARDS:HDAC3 REACTOME:401336 KEGG:8841 ATLASONC:HDAC3ID40804ch5q31 WIKI:HDAC3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21234400 Histone deacetylase References_end</body> </html> </notes> <label text="HDAC3"/> <bbox w="80.0" h="40.0" x="18231.0" y="3070.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s145_shh1_shh2_sa131" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> </notes> <label text="JUN"/> <clone/> <bbox w="80.0" h="40.0" x="18269.0" y="3000.0"/> <glyph class="state variable" id="_9105a0b5-6cae-4639-937c-0f4939ffcd64"> <state value="P" variable="S63"/> <bbox w="30.0" h="10.0" x="18254.492" y="2995.0"/> </glyph> <glyph class="state variable" id="_ae515ebe-9ce1-401f-9711-d3b030aa095a"> <state value="P" variable="S73"/> <bbox w="30.0" h="10.0" x="18294.031" y="2995.0"/> </glyph> <glyph class="state variable" id="_ec714641-5d7f-40aa-b0fb-26839cfab864"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18264.0" y="3015.0"/> </glyph> <glyph class="state variable" id="_30f887a2-638d-4643-a2dd-0aead52d09c4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18264.0" y="2995.0"/> </glyph> <glyph class="state variable" id="_7367b357-43f6-487d-ac09-9b947aaccad8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18264.0" y="3035.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s145_shh1_shh2_sa139" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN jun proto-oncogene "jun oncogene" "v-jun avian sarcoma virus 17 oncogene homolog" "v-jun sarcoma virus 17 oncogene homolog (avian)" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 Jun proto-oncogene AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> </notes> <label text="JUN"/> <clone/> <bbox w="80.0" h="40.0" x="18282.375" y="4227.0"/> <glyph class="state variable" id="_5cfefd44-fd07-46c2-91a7-7e9e72e40fea"> <state value="P" variable="S63"/> <bbox w="30.0" h="10.0" x="18267.867" y="4222.0"/> </glyph> <glyph class="state variable" id="_124f1496-3b27-4079-9afa-8bd62355dc97"> <state value="P" variable="S73"/> <bbox w="30.0" h="10.0" x="18307.406" y="4222.0"/> </glyph> <glyph class="state variable" id="_19f20e58-57d9-4433-aabf-486501998639"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18277.375" y="4242.0"/> </glyph> <glyph class="state variable" id="_93ca1f59-0c3c-4b94-8175-daabc95f243c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18277.375" y="4222.0"/> </glyph> <glyph class="state variable" id="_eb705978-38fe-431a-aa26-f8959501e7d8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18277.375" y="4262.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s193_shh1_shh2_sa173" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 transcription factor 7-like 1 (T-cell specific HMG-box) TCF3 HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 transcription factor 7-like 2 (T-cell specific HMG-box) TCF4 HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end</body> </html> Identifiers_begin: pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) HUGO:PCBD2 HGNC:24474 ENTREZ:84105 UNIPROT:Q9H0N5 GENECARDS:PCBD2 KEGG:84105 WIKI:PCBD2 HNF1 homeobox A MODY3 TCF1 "transcription factor 1 hepatic; LF-B1 hepatic nuclear factor (HNF1) albumin proximal factor" HUGO:HNF1A HGNC:11621 ENTREZ:6927 UNIPROT:P20823 GENECARDS:HNF1A REACTOME:403244 KEGG:6927 ATLASONC:GC_HNF1A WIKI:HNF1A HNF1 homeobox B TCF2 "transcription factor 2 hepatic; LF-B3; variant hepatic nuclear factor" HUGO:HNF1B HGNC:11630 ENTREZ:6928 UNIPROT:P35680 GENECARDS:HNF1B REACTOME:403844 KEGG:6928 ATLASONC:GC_HNF1B WIKI:HNF1B transcription factor 3 HUGO:TCF3 HGNC:11633 ENTREZ:6929 UNIPROT:P15923 GENECARDS:TCF3 REACTOME:65901 KEGG:6929 ATLASONC:E2A WIKI:TCF3 transcription factor 4 HUGO:TCF4 HGNC:11634 ENTREZ:6925 UNIPROT:P15884 GENECARDS:TCF4 REACTOME:57613 KEGG:6925 ATLASONC:GC_TCF4 WIKI:TCF4 CCAAT/enhancer binding protein (C/EBP) beta TCF5 HUGO:CEBPB HGNC:1834 ENTREZ:1051 UNIPROT:P17676 GENECARDS:CEBPB REACTOME:51866 KEGG:1051 ATLASONC:GC_CEBPB WIKI:CEBPB transcription factor-like 5 (basic helix-loop-helix) HUGO:TCFL5 HGNC:11646 ENTREZ:10732 UNIPROT:Q9UL49 GENECARDS:TCFL5 KEGG:10732 WIKI:TCFL5 info transcription factor A mitochondrial HUGO:TFAM HGNC:11741 ENTREZ:7019 UNIPROT:Q00059 GENECARDS:TFAM REACTOME:65899 KEGG:7019 ATLASONC:GC_TFAM WIKI:TFAM transcription factor 7 (T-cell specific HMG-box) HUGO:TCF7 HGNC:11639 ENTREZ:6932 UNIPROT:P36402 GENECARDS:TCF7 KEGG:6932 ATLASONC:GC_TCF7 WIKI:TCF7 transcription factor 7-like 1 (T-cell specific HMG-box) HUGO:TCF7L1 HGNC:11640 ENTREZ:83439 UNIPROT:Q9HCS4 GENECARDS:TCF7L1 KEGG:83439 ATLASONC:GC_TCF7L1 WIKI:TCF7L1 transcription factor 7-like 2 (T-cell specific HMG-box) HUGO:TCF7L2 HGNC:11641 ENTREZ:6934 UNIPROT:Q9NQB0 GENECARDS:TCF7L2 REACTOME:65596 KEGG:6934 ATLASONC:GC_TCF7L2 WIKI:TCF7L2 zinc finger E-box binding homeobox 1 TCF8 HUGO:ZEB1 HGNC:11642 ENTREZ:6935 UNIPROT:P37275 GENECARDS:ZEB1 KEGG:6935 ATLASONC:GC_ZEB1 WIKI:ZEB1 GC-rich sequence DNA-binding factor 2 PREVIOUS SYMBOLS/ C2orf3 "chromosome 2 open reading frame 3" TCF9 "transcription factor 9 (binds GC-rich sequences)" HUGO:GCFC2 HGNC:1317 ENTREZ:6936 UNIPROT:P16383 GENECARDS:GCFC2 KEGG:6936 WIKI:GCFC2 lymphoid enhancer-binding factor 1 HUGO:LEF1 HGNC:6551 ENTREZ:51176 UNIPROT:Q9UJU2 GENECARDS:LEF1 KEGG:51176 ATLASONC:GC_LEF1 WIKI:LEF1 nuclear factor (erythroid-derived 2)-like 1 TCF11 HUGO:NFE2L1 HGNC:7781 ENTREZ:4779 UNIPROT:Q14494 GENECARDS:NFE2L1 KEGG:4779 ATLASONC:GC_NFE2L1 WIKI:NFE2L1 transcription factor 12 HUGO:TCF12 HGNC:11623 ENTREZ:6938 UNIPROT:Q99081 GENECARDS:TCF12 REACTOME:56728 KEGG:6938 ATLASONC:TCF12ID406 WIKI:TCF12 TEA domain family member 1 (SV40 transcriptional enhancer factor) AA "atrophia areata peripapillary chorioretinal degeneration" TCF13 HUGO:TEAD1 HGNC:11714 ENTREZ:7003 UNIPROT:P28347 GENECARDS:TEAD1 REACTOME:65831 KEGG:7003 ATLASONC:GC_TEAD1 WIKI:TEAD1 TEA domain family member 4 TCF13L1 HUGO:TEAD4 HGNC:11717 ENTREZ:7004 UNIPROT:Q15561 GENECARDS:TEAD4 REACTOME:65837 KEGG:7004 WIKI:TEAD4 hepatocyte nuclear factor 4 alpha MODY MODY1 TCF14 HUGO:HNF4A HGNC:5024 ENTREZ:3172 UNIPROT:P41235 GENECARDS:HNF4A REACTOME:211473 KEGG:3172 ATLASONC:GC_HNF4A WIKI:HNF4A transcription factor 15 (basic helix-loop-helix) HUGO:TCF15 HGNC:11627 ENTREZ:6939 UNIPROT:Q12870 GENECARDS:TCF15 KEGG:6939 ATLASONC:GC_TCF15 WIKI:TCF15 conserved helix-loop-helix ubiquitous kinase TCF16 HUGO:CHUK HGNC:1974 ENTREZ:1147 UNIPROT:O15111 GENECARDS:CHUK REACTOME:57214 KEGG:1147 ATLASONC:GC_CHUK WIKI:CHUK zinc finger protein 354A TCF17 HUGO:ZNF354A HGNC:11628 ENTREZ:6940 UNIPROT:O60765 GENECARDS:ZNF354A REACTOME:65741 KEGG:6940 WIKI:ZNF354A transcription factor 19 HUGO:TCF19 HGNC:11629 ENTREZ:6941 UNIPROT:Q9Y242 GENECARDS:TCF19 KEGG:6941 WIKI:TCF19 transcription factor 20 HUGO:TCF20 HGNC:11631 ENTREZ:6942 UNIPROT:Q9UGU0 GENECARDS:TCF20 KEGG:6942 WIKI:TCF20 transcription factor 21 HUGO:TCF21 HGNC:11632 ENTREZ:6943 UNIPROT:O43680 GENECARDS:TCF21 KEGG:6943 ATLASONC:GC_TCF21 WIKI:TCF21 transcription factor 23 HUGO:TCF23 HGNC:18602 ENTREZ:150921 UNIPROT:Q7RTU1 GENECARDS:TCF23 KEGG:150921 WIKI:TCF23 transcription factor 24 HUGO:TCF24 HGNC:32275 ENTREZ:100129654 UNIPROT:Q7RTU0 GENECARDS:TCF24 KEGG:100129654 WIKI:TCF24 transcription factor 25 HUGO:TCF25 HGNC:29181 ENTREZ:22980 UNIPROT:Q9BQ70 GENECARDS:TCF25 KEGG:22980 ATLASONC:GC_TCF25 WIKI:TCF25 TCF3 TCF4 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19623618 PMID:19619488 HNF1 homeobox Phosphorylation sites specific for HIPK2 not known PMID:21285352 References_end</body> </html> </notes> <label text="LEF_TCF*"/> <bbox w="80.0" h="40.0" x="19217.5" y="4225.0"/> <glyph class="state variable" id="_4c9b9425-6c3f-42d9-ba33-642ab5cdc63b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19292.5" y="4220.878"/> </glyph> <glyph class="state variable" id="_f4c25d75-a741-49f2-ab8a-31e276fc9773"> <state value="" variable="S40"/> <bbox w="25.0" h="10.0" x="19285.0" y="4256.6143"/> </glyph> <glyph class="state variable" id="_345a28ed-b469-407b-b613-acb7b575b9c9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19292.5" y="4240.0"/> </glyph> <glyph class="state variable" id="_a71aa42a-7577-4f36-9b7c-55a5b4698e6e"> <state value="" variable="S166"/> <bbox w="30.0" h="10.0" x="19202.992" y="4220.0"/> </glyph> <glyph class="state variable" id="_bba080c2-9243-4761-adfc-187a20eae4ee"> <state value="" variable="T155"/> <bbox w="30.0" h="10.0" x="19202.5" y="4259.722"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s134_shh1_shh2_sa122" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re81:(MAP:survival) PMID:11960000 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Sin3 homologue A transcription regulator HUGO:SIN3A HGNC:19353 ENTREZ:25942 UNIPROT:Q96ST3 GENECARDS:SIN3A REACTOME:101853 ATLASONC:GC_SIN3A WIKI:SIN3A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11960000 References_end</body> </html> </notes> <label text="MSIN3*"/> <bbox w="80.0" h="40.0" x="18337.0" y="4491.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s286_shh1_shh2_sa250" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: N-myc HUGO:MYCN HGNC:7559 ENTREZ:4613 UNIPROT:P04198 GENECARDS:MYCN KEGG:4613 ATLASONC:NMYC112 WIKI:MYCN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:15061133 References_end</body> </html> </notes> <label text="MYCN"/> <bbox w="80.0" h="40.0" x="19077.0" y="4142.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s38_shh1_shh1_sa167" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Protein kinase cAMP-depenedent catalytic alpha HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA Protein kinase cAMP-depenedent catalytic beta HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB Protein kinase cAMP-depenedent catalytic gamma HUGOPRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20027184 References_end</body> </html> </notes> <label text="PKA*"/> <clone/> <bbox w="80.0" h="40.0" x="18887.5" y="546.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s38_shh1_shh1_sa172" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Protein kinase cAMP-depenedent catalytic alpha HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA Protein kinase cAMP-depenedent catalytic beta HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB Protein kinase cAMP-depenedent catalytic gamma HUGOPRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20027184 References_end</body> </html> </notes> <label text="PKA*"/> <clone/> <bbox w="80.0" h="40.0" x="18701.5" y="546.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s102_shh1_shh2_sa92" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re61:(MAP:survival) PMID:19996099 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Protein kinase cAMP-depenedent catalytic alpha HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA Protein kinase cAMP-depenedent catalytic beta HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB Protein kinase cAMP-depenedent catalytic gamma HUGOPRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20027184 References_end</body> </html> </notes> <label text="PKA*"/> <bbox w="80.0" h="40.0" x="18516.0" y="3452.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s133_shh1_shh2_sa121" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re81:(MAP:survival) PMID:11960000 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Sin3A-associated protein 18 kDa HUGO:SAP18 HGNC:10530 ENTREZ:10284 UNIPROT:O00422 GENECARDS:SAP18 KEGG:10284 ATLASONC:GC_SAP18 WIKI:SAP18 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11960000 References_end</body> </html> </notes> <label text="SAP18"/> <bbox w="80.0" h="40.0" x="18337.0" y="4408.5"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s243_shh1_shh2_sa211" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re3:(MAP:survival) PMID:12435627 PMID:19032343 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Ski HUGO:SKI HGNC:10896 ENTREZ:6497 UNIPROT:P12755 GENECARDS:SKI REACTOME:64528 KEGG:6497 ATLASONC:GC_SKI WIKI:SKI Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19114989 V-ski sarcoma viral oncogene homologue (avian) References_end</body> </html> </notes> <label text="SKI"/> <bbox w="80.0" h="40.0" x="18313.0" y="3070.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s247_shh1_shh2_sa215" compartmentRef="shh1_shh2_c3_shh1_shh2_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Smoothened HUGO:SMO HGNC:11119 ENTREZ:6608 UNIPROT:Q99835 GENECARDS:SMO REACTOME:64670 KEGG:6608 ATLASONC:GC_SMO WIKI:SMO Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18820483 PMID:17641202 Smoothened homologue (Drosophila) References_end</body> </html> </notes> <label text="SMO"/> <bbox w="80.0" h="40.0" x="18708.0" y="2643.0"/> <glyph class="state variable" id="_d5bb0aab-6bbb-4a70-a53b-617ce770e5e3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18783.0" y="2638.0"/> </glyph> <glyph class="state variable" id="_b10846ad-718b-43f7-ade1-0b335eab3970"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18783.0" y="2638.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s131_shh1_shh1_sa128" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <clone/> <bbox w="80.0" h="40.0" x="17996.0" y="466.0"/> <glyph class="state variable" id="_72cfa056-7e47-4117-9131-9e483452a782"> <state value="" variable="K257"/> <bbox w="30.0" h="10.0" x="17981.492" y="461.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s131_shh1_shh1_sa198" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <clone/> <bbox w="80.0" h="40.0" x="19983.25" y="1108.0"/> <glyph class="state variable" id="_e05cf157-a427-4a23-9e1e-7a1885531c78"> <state value="" variable="K257"/> <bbox w="30.0" h="10.0" x="19968.742" y="1103.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s131_shh1_shh1_sa210" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <clone/> <bbox w="80.0" h="40.0" x="19034.25" y="1618.7703"/> <glyph class="state variable" id="_20ae4584-229d-4688-a1d1-78392ec56cc1"> <state value="" variable="K257"/> <bbox w="30.0" h="10.0" x="19019.742" y="1613.7703"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s131_shh1_shh1_sa226" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <clone/> <bbox w="80.0" h="40.0" x="18128.25" y="1242.0"/> <glyph class="state variable" id="_cffc43a3-633d-4759-b956-09f08ce6fe59"> <state value="" variable="K257"/> <bbox w="30.0" h="10.0" x="18113.742" y="1237.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s131_shh1_shh1_sa244" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <clone/> <bbox w="80.0" h="40.0" x="18432.5" y="2050.0"/> <glyph class="state variable" id="_fb62b133-54cd-45b8-aa65-f5370f4612ef"> <state value="" variable="K257"/> <bbox w="30.0" h="10.0" x="18417.992" y="2045.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s132_shh1_shh2_sa120" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re81:(MAP:survival) PMID:11960000 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <bbox w="80.0" h="40.0" x="18336.5" y="4328.0"/> <glyph class="state variable" id="_8628ff8e-da44-4acf-a101-2e5528075b1a"> <state value="" variable="K257"/> <bbox w="30.0" h="10.0" x="18321.992" y="4323.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s194_shh1_shh2_sa174" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re119:(MAP:survival) PMID:17297467 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="19217.5" y="4306.0"/> <glyph class="state variable" id="_4b3b974f-1664-474a-85f0-01acb62cd820"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="19244.904" y="4341.0"/> </glyph> <glyph class="state variable" id="_8cc7edf3-8b6f-4044-bc91-0f410a7e503b"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="19284.38" y="4341.0"/> </glyph> <glyph class="state variable" id="_2b53cb9f-08e8-4785-b5b6-dea21772f2fb"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="19285.0" y="4301.215"/> </glyph> <glyph class="state variable" id="_e262ce81-a6d4-4202-9aac-2e9ad0eb0ef8"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="19245.031" y="4301.0"/> </glyph> <glyph class="state variable" id="_afc5af5d-d943-44c4-a300-a58c0a8c9fe7"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="19205.492" y="4301.0"/> </glyph> <glyph class="state variable" id="_edca9b99-7913-4f1b-8be6-90592beba63b"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="19205.0" y="4340.722"/> </glyph> <glyph class="state variable" id="_89a20a97-3fb4-4b81-ba2f-8fa9ff3b065e"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="19282.5" y="4301.215"/> </glyph> <glyph class="state variable" id="_ff6d3e71-a76a-4284-95e2-c8e93ef4f4e0"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="19282.5" y="4301.215"/> </glyph> <glyph class="state variable" id="_f8d03ebc-8790-4c6e-bcd3-2125fd58b042"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19212.5" y="4321.0"/> </glyph> <glyph class="state variable" id="_f4e0105c-5513-4142-bd86-34d5471a9947"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="19202.992" y="4301.0"/> </glyph> <glyph class="state variable" id="_78d0cac6-0436-4ca3-be6d-d19bcdd51ac7"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="19282.5" y="4301.215"/> </glyph> <glyph class="state variable" id="_ba312430-72ed-4209-9d7c-46acca3072b5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19212.5" y="4312.716"/> </glyph> <glyph class="state variable" id="_4c6d55bd-2502-470d-80b3-8c49fe46c6e4"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="19282.5" y="4301.215"/> </glyph> <glyph class="state variable" id="_662614ad-0ec6-4349-89bc-55af9cb6261f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19212.5" y="4321.0"/> </glyph> <glyph class="state variable" id="_05edfc2f-95d7-411b-b4f9-4d619053a653"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="19281.88" y="4341.0"/> </glyph> <glyph class="state variable" id="_1a13d059-c862-4e84-819f-88f5fdb35844"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="19282.5" y="4301.215"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh2_s230_shh1_shh2_sa204" compartmentRef="shh1_shh2_c3_shh1_shh2_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_wca3_re74:(MAP:survival) PMID:20508033 s_wnc4_re31(MAP:survival): binding of G-alpha12 toE-cadherin results of loss of binding of b-catenin from the adherence junction PMID:11136230 s_shh2_re119:(MAP:survival) PMID:17297467 s_mpk1_re105(MAP:survival): Phosphorylation of beta-catenin (CTNNB1) by GSK-3beta (GSK3B) causes its degradation PMID:16039586 s_mpk1_re106(MAP:survival): Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). s_wca1_re1:(MAP:survival) PMID:17143292 s_wca2_re1:(MAP:survival) PMID:21490931 s_wca2_re40:(MAP:survival) PMID:22203675 s_wca2_re51:(MAP:survival) PMID:21152425 PMID:19244247 s_wca2_re62:(MAP:survival) PMID:22705350 s_wca3_re3(MAP:survival): Upon wnt signalling beta-catenin is not degraded and can enter the nucleus BCL9 and PYGO stimulate translocation of b-catenin. PMID:15208637 No active transport of b-catenin localisation of b-catenin by retention of the binding partners PMID:16554443 s_wca4_re1:(MAP:survival) PMID:22699938 s_wnc1_re2(MAP:survival): PMID:21506126 Phosphorylation of beta-catenin is through an indirect mechanism which is unknown PMID:21303971 Path to phosphorylation of b-catenin is not completely depicted here. For full paths see AKT-MODULE s_wnc2_re4(MAP:survival): PMID:21506126, PMID:21303971 Path to phosphorylation of b-catenin is not completely depicted here. For full paths see AKT-pathway Activated CaSR inhibits phosphorylation of b-catenin, exact mechanism unknown PMID:22094462 s_wnc4_re24(MAP:survival): Complex of G-alpha12 and p120 stabilises binding of E-cadherin in Adhesion-complex. G-alpha12 is found back in complex with p120 and E-cadherin PMID:15240885 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: catenin (cadherin-associated protein) beta 1 88kDa "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end Identifiers_begin: Catenin (cadherin-associated protein) beta 1 88 kDa HUGO:CTNNB1 HGNC:2514 ENTREZ:1499 UNIPROT:P35222 GENECARDS:CTNNB1 REACTOME:53048 KEGG:1499 ATLASONC:CTNNB1ID71 WIKI:CTNNB1 "catenin (cadherin-associated protein) beta 1 (88kD)" CTNNB catenin (cadherin-associated protein) beta 1 armadillo, beta-catenin Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CELL_CELL_ADHESIONS MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19619488 ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 PMID:16039586 PMID:17143292 PMID:23343194 References_end</body> </html> </notes> <label text="β-Catenin*"/> <bbox w="80.0" h="40.0" x="18563.5" y="2641.0"/> <glyph class="state variable" id="_7f04522b-2487-4ff0-b8f7-157bb5087ba2"> <state value="" variable="S45"/> <bbox w="25.0" h="10.0" x="18590.904" y="2676.0"/> </glyph> <glyph class="state variable" id="_d4094c84-6215-4b7d-a8c6-8f021dbd99fa"> <state value="" variable="T41"/> <bbox w="25.0" h="10.0" x="18630.38" y="2676.0"/> </glyph> <glyph class="state variable" id="_10087ffe-20e3-469b-a837-0096f3d6798b"> <state value="" variable="S37"/> <bbox w="25.0" h="10.0" x="18631.0" y="2636.2148"/> </glyph> <glyph class="state variable" id="_38adc95f-f116-4425-8d2c-5535ec83f109"> <state value="" variable="S33"/> <bbox w="25.0" h="10.0" x="18591.031" y="2636.0"/> </glyph> <glyph class="state variable" id="_3ec323ec-cc14-484d-b013-788c8e15b1cd"> <state value="" variable="K19"/> <bbox w="25.0" h="10.0" x="18551.492" y="2636.0"/> </glyph> <glyph class="state variable" id="_e63bfaf8-e5b5-4d4b-bca4-5e8761990aaf"> <state value="" variable="K49"/> <bbox w="25.0" h="10.0" x="18551.0" y="2675.7224"/> </glyph> <glyph class="state variable" id="_6087d03a-318d-48cb-b884-edfac3131201"> <state value="" variable="Y142"/> <bbox w="30.0" h="10.0" x="18628.5" y="2636.2148"/> </glyph> <glyph class="state variable" id="_7982e252-8ce5-4715-9b42-0e3e2e257407"> <state value="" variable="S552"/> <bbox w="30.0" h="10.0" x="18628.5" y="2636.2148"/> </glyph> <glyph class="state variable" id="_453a9a59-519e-43da-9ec2-5a9bfd087159"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18558.5" y="2656.0"/> </glyph> <glyph class="state variable" id="_b47d0aa4-6c4a-428f-b952-95bb1b000bed"> <state value="" variable="K394"/> <bbox w="30.0" h="10.0" x="18548.992" y="2636.0"/> </glyph> <glyph class="state variable" id="_0d10c7ca-959c-482d-b2cc-90b7d77c8881"> <state value="" variable="Y654"/> <bbox w="30.0" h="10.0" x="18628.5" y="2636.2148"/> </glyph> <glyph class="state variable" id="_334fea7c-42c2-42e2-9b7e-a4b2b1eb0f81"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18558.5" y="2647.7158"/> </glyph> <glyph class="state variable" id="_ab9f84f2-133f-45d1-b222-bd609a9c9126"> <state value="" variable="S522"/> <bbox w="30.0" h="10.0" x="18628.5" y="2636.2148"/> </glyph> <glyph class="state variable" id="_f3751683-6e89-4c3d-af77-be506918b263"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18558.5" y="2656.0"/> </glyph> <glyph class="state variable" id="_18b72f07-587c-4139-a0e3-f1d7707448b2"> <state value="" variable="S675"/> <bbox w="30.0" h="10.0" x="18627.88" y="2676.0"/> </glyph> <glyph class="state variable" id="_cc6912a7-f8ac-488b-87b9-0e822b9c0726"> <state value="" variable="K345"/> <bbox w="30.0" h="10.0" x="18628.5" y="2636.2148"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s171_shh1_shh2_sa153" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re97:(MAP:survival) PMID:19190345 PMID:16880536 s_shh2_re98:(MAP:survival) PMID:17466953 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Activity-regulated cytoskeleton-associated protein HUGO:ARC HGNC:648 ENTREZ:23237 UNIPROT:Q7LC44 GENECARDS:ARC KEGG:8996 ATLASONC:GC_ARC WIKI:ARC Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16599904 References_end</body> </html> </notes> <label text="ARC"/> <bbox w="90.0" h="25.0" x="18841.0" y="4321.5"/> <glyph class="unit of information" id="_8edb2d55-22c4-48be-b65a-59a162b38c6e"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18876.0" y="4316.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s263_shh1_shh2_sa232" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re134:(MAP:survival) PMID:21245165 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Bak HUGO:BAK1 HGNC:949 ENTREZ:578 UNIPROT:Q16611 GENECARDS:BAK1 REACTOME:50691 KEGG:578 ATLASONC:BAK1ID752ch6p21 WIKI:BAK1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21195116 References_end</body> </html> </notes> <label text="BAK1"/> <bbox w="90.0" h="25.0" x="19557.0" y="4322.5"/> <glyph class="unit of information" id="_870edeb6-c6e1-465d-b34f-ce06a60ba55f"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="19592.0" y="4317.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s262_shh1_shh2_sa231" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re133:(MAP:survival) PMID:21245165 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2 binding component 3 HUGO:BBC3 HGNC:17868 ENTREZ:27113 UNIPROT:Q96PG8 GENECARDS:BBC3 KEGG:27113 ATLASONC:BBC3ID759ch19q13 WIKI:BBC3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19652530 PMID:20673124 References_end Identifiers_begin: BCL2 binding component 3 HUGO:BBC3 HGNC:17868 ENTREZ:27113 UNIPROT:Q96PG8 GENECARDS:BBC3 KEGG:27113 ATLASONC:BBC3ID759ch19q13 WIKI:BBC3 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19652530 PMID:20673124 References_end</body> </html> </notes> <label text="BBC3"/> <bbox w="90.0" h="25.0" x="19557.0" y="4288.5"/> <glyph class="unit of information" id="_70cf35ab-2900-417e-b39c-54bef88c633e"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="19592.0" y="4283.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s95_shh1_shh2_sa89" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re58:(MAP:survival) PMID:15520176 PMID:14555646 s_shh2_re60:(MAP:survival) PMID:19736394 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Bcl-2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 GENECARDS:BCL2 REACTOME:50758 KEGG:596 ATLASONC:BCL2ID49 WIKI:BCL2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18097445 PMID:9735050 References_end Identifiers_begin: Bcl-2 HUGO:BCL2 HGNC:990 ENTREZ:596 UNIPROT:P10415 GENECARDS:BCL2 REACTOME:50758 KEGG:596 ATLASONC:BCL2ID49 WIKI:BCL2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18097445 PMID:9735050 References_end</body> </html> </notes> <label text="BCL2"/> <bbox w="90.0" h="25.0" x="18841.0" y="4015.5"/> <glyph class="unit of information" id="_9eecd43a-c3cb-4da6-a2d0-38f1934e0b2a"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18876.0" y="4010.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s259_shh1_shh2_sa228" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re146:(MAP:survival) PMID18493594 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 GENECARDS:BCL2L11 REACTOME:401534 KEGG:10018 ATLASONC:BCL2L11ID772ch2q13 WIKI:BCL2L11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19934277 PMID:20673124 References_end Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 GENECARDS:BCL2L11 REACTOME:401534 KEGG:10018 ATLASONC:BCL2L11ID772ch2q13 WIKI:BCL2L11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19934277 PMID:20673124 References_end</body> </html> </notes> <label text="BCL2L11"/> <clone/> <bbox w="90.0" h="25.0" x="19557.0" y="4186.5"/> <glyph class="unit of information" id="_49ea7225-d73a-4dcc-956c-49a55b0f4724"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="19592.0" y="4181.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s259_shh1_shh2_sa257" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re146:(MAP:survival) PMID18493594 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 GENECARDS:BCL2L11 REACTOME:401534 KEGG:10018 ATLASONC:BCL2L11ID772ch2q13 WIKI:BCL2L11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19934277 PMID:20673124 References_end Identifiers_begin: BCL2-like 11 (apoptosis facilitator) HUGO:BCL2L11 HGNC:994 ENTREZ:10018 UNIPROT:O43521 GENECARDS:BCL2L11 REACTOME:401534 KEGG:10018 ATLASONC:BCL2L11ID772ch2q13 WIKI:BCL2L11 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19934277 PMID:20673124 References_end</body> </html> </notes> <label text="BCL2L11"/> <clone/> <bbox w="90.0" h="25.0" x="19552.0" y="4391.5"/> <glyph class="unit of information" id="_14e12fbb-113e-4d8a-9472-424276c2b648"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="19587.0" y="4386.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s260_shh1_shh2_sa229" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re131:(MAP:survival) PMID:21245165 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: BMF HUGO:BMF HGNC:24132 ENTREZ:90427 UNIPROT:Q96LC9 GENECARDS:BMF REACTOME:140208 ATLASONC:GC_BMF WIKI:BMF Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16243507 References_end</body> </html> </notes> <label text="BMF"/> <bbox w="90.0" h="25.0" x="19557.0" y="4220.5"/> <glyph class="unit of information" id="_25cdcca1-5133-4af1-b22a-93f7985749c7"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="19592.0" y="4215.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s301_shh1_shh2_sa261" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re150(MAP:survival): PMID:16878133 PMID:18550634 Not known which miRNA of the miR-17-92 polycistron is reponsible for degradation of Tsp1 and CTGF therefor only miR-17-3p shown in complex References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: connective tissue growth factor HUGO:CTGF HGNC:2500 ENTREZ:1490 UNIPROT:P29279 GENECARDS:CTGF REACTOME:53030 KEGG:1490 ATLASONC:CTGFID40192ch6q23 WIKI:CTGF Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19449449 References_end</body> </html> </notes> <label text="CTGF"/> <bbox w="90.0" h="25.0" x="19552.0" y="4472.5"/> <glyph class="unit of information" id="_60e8c6a5-9abb-4918-a858-75192d1aeb49"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="19587.0" y="4467.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s71_shh1_shh2_sa65" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re154:(MAP:survival) PMID:18695042 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 PMID:20673124 References_end Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 PMID:20673124 References_end Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 PMID:20673124 References_end</body> </html> </notes> <label text="CyclinD*"/> <clone/> <bbox w="90.0" h="25.0" x="18841.0" y="3805.5"/> <glyph class="unit of information" id="_e9e1880e-81dd-483c-bd98-de45cb28cd47"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18876.0" y="3800.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s71_shh1_shh2_sa273" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re154:(MAP:survival) PMID:18695042 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 PMID:20673124 References_end Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 PMID:20673124 References_end Identifiers_begin: cyclin D1 HUGO:CCND1 HGNC:1582 ENTREZ:595 UNIPROT:P24385 GENECARDS:CCND1 REACTOME:68327 KEGG:595 ATLASONC:BCL1 WIKI:CCND1 cyclin D2 HUGO:CCND2 HGNC:1583 ENTREZ:894 UNIPROT:P30279 GENECARDS:CCND2 REACTOME:68339 KEGG:894 ATLASONC:GC_CCND2 WIKI:CCND2 cyclin D3 HUGO:CCND3 HGNC:1585 ENTREZ:896 UNIPROT:P30281 GENECARDS:CCND3 REACTOME:68332 ATLASONC:GC_CCND3 WIKI:CCND3 Identifiers_end Maps_Modules_begin: MAP:dnarepair / MODULE:G1_CC_PHASE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18414028 PMID:19887899 PMID:20673124 References_end</body> </html> </notes> <label text="CyclinD*"/> <clone/> <bbox w="90.0" h="25.0" x="19552.0" y="4552.0"/> <glyph class="unit of information" id="_56677c72-9ea4-4b57-ad05-93dd6eb6e52d"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="19587.0" y="4547.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s19_shh1_shh2_sa15" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re4:(MAP:survival) PMID:20562908 s_shh2_re5:(MAP:survival) PMID:19736394 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Tumor necrosis factor receptor superfamily member 10a HUGO:TNFRSF10A HGNC:11904 ENTREZ:8797 UNIPROT:O00220 GENECARDS:TNFRSF10A KEGG:8797 ATLASONC:GC_TNFRSF10A WIKI:TNFRSF10A Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20562908 References_end</body> </html> </notes> <label text="Death receptor4*"/> <bbox w="90.0" h="25.0" x="18840.0" y="3033.5"/> <glyph class="unit of information" id="_8b1cbcdf-7307-42a2-a774-4401787d3fe9"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18875.0" y="3028.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s291_shh1_shh2_sa254" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re144:(MAP:survival) PMID:15944709 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: E2F transcription factor 1 HUGO:E2F1 HGNC:3113 ENTREZ:1869 UNIPROT:Q01094 GENECARDS:E2F1 REACTOME:89561 KEGG:1869 ATLASONC:E2F1ID40382ch20q11 WIKI:E2F1 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17218262 References_end</body> </html> </notes> <label text="E2F1"/> <bbox w="90.0" h="25.0" x="19557.0" y="4355.5"/> <glyph class="unit of information" id="_6c60a80e-32ad-49cc-8590-753c0a95f613"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="19592.0" y="4350.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s322_shh1_shh2_sa277" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re157:(MAP:survival) PMID:19684618 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: estrogen receptor 1 HUGO:ESR1 HGNC:3467 ENTREZ:2099 UNIPROT:P03372 GENECARDS:ESR1 REACTOME:69672 KEGG:2099 ATLASONC:GC_ESR1 WIKI:ESR1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21267694 References_end</body> </html> </notes> <label text="ERα*"/> <bbox w="90.0" h="25.0" x="19546.0" y="4628.5"/> <glyph class="unit of information" id="_67d21354-d5f6-4fff-95aa-4ca26c6cd3f9"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="19581.0" y="4623.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s52_shh1_shh2_sa46" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re22:(MAP:survival) PMID:18813803 PMID:16880536 PMID:19190345 s_shh2_re23:(MAP:survival) PMID:19424602 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Forkhead box A2 HUGO:FOXA2 HGNC:5022 ENTREZ:3170 UNIPROT:Q9Y261 GENECARDS:FOXA2 REACTOME:56610 KEGG:3170 ATLASONC:GC_FOXA2 WIKI:FOXA2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16909212 References_end</body> </html> </notes> <label text="FOXA2"/> <bbox w="90.0" h="25.0" x="18840.0" y="3216.5"/> <glyph class="unit of information" id="_dcb3c5a0-3d7e-4e4b-8e43-00d7f6ee76ea"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18875.0" y="3211.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s55_shh1_shh2_sa49" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re25:(MAP:survival) PMID:18813803 s_shh2_re27:(MAP:survival) PMID:18539112 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Forkhead box C2 HUGO:FOXC2 HGNC:3801 ENTREZ:2303 UNIPROT:Q99958 GENECARDS:FOXC2 KEGG:2303 ATLASONC:GC_FOXC2 WIKI:FOXC2 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20713713 PMID:18539112 References_end</body> </html> </notes> <label text="FOXC2"/> <bbox w="90.0" h="25.0" x="18840.0" y="3264.5"/> <glyph class="unit of information" id="_0c17abe4-8e0c-41bd-b2fe-7941458fc562"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18875.0" y="3259.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s67_shh1_shh2_sa61" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re38:(MAP:survival) PMID:15140221 PMID:18813803 PMID:18698484 s_shh2_re39:(MAP:survival) PMID:19424602 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Forkhead box E1 HUGO:FOXE1 HGNC:3806 ENTREZ:2304 UNIPROT:O00358 GENECARDS:FOXE1 KEGG:2304 ATLASONC:FOXE1ID47197ch9q22 WIKI:FOXE1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:15140221 PMID:18698484 References_end</body> </html> </notes> <label text="FOXE1"/> <bbox w="90.0" h="25.0" x="18840.0" y="3312.5"/> <glyph class="unit of information" id="_ec8fcdf7-a496-4824-8e6c-cb5aa0faaaee"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18875.0" y="3307.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s47_shh1_shh2_sa41" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re20(MAP:survival): PMID:19049965 PMID:11493558 s_shh2_re21:(MAP:survival) PMID:20145151 s_shh2_re31:(MAP:survival) PMID:19424602 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Forkhead box F1 HUGO:FOXF1 HGNC:3809 ENTREZ:2294 UNIPROT:Q12946 GENECARDS:FOXF1 KEGG:2294 ATLASONC:FOXF1ID40628ch16q24 WIKI:FOXF1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19424602 PMID:20587515 PMID:19049965 PMID:11493558 PMID:20145151 References_end</body> </html> </notes> <label text="FOXF1"/> <bbox w="90.0" h="25.0" x="18840.0" y="3124.5"/> <glyph class="unit of information" id="_0dedf0c9-4d04-4a90-9e26-a75d9c2b4d62"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18875.0" y="3119.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s49_shh1_shh2_sa43" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re19:(MAP:survival) PMID:19049965 s_shh2_re30:(MAP:survival) PMID:19424602 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Forkhead box L1 HUGO:FOXL1 HGNC:3817 ENTREZ:2300 UNIPROT:Q12952 GENECARDS:FOXL1 KEGG:2300 ATLASONC:GC_FOXL1 WIKI:FOXL1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20145151 References_end</body> </html> </notes> <label text="FOXL1"/> <bbox w="90.0" h="25.0" x="18840.0" y="3170.5"/> <glyph class="unit of information" id="_b5092445-80ae-41fd-a61a-3454191c0aef"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18875.0" y="3165.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s69_shh1_shh2_sa63" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re40:(MAP:survival) PMID:20712011 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Forkhead box M1 HUGO:FOXM1 HGNC:3818 ENTREZ:2305 UNIPROT:Q08050 GENECARDS:FOXM1 KEGG:2305 ATLASONC:FOXM1ID40631ch12p13 WIKI:FOXM1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20712011 PMID:21062979 References_end</body> </html> </notes> <label text="FOXM1"/> <bbox w="90.0" h="25.0" x="18840.0" y="3358.5"/> <glyph class="unit of information" id="_389c0f4c-da25-4b25-852a-7a3d5c222e82"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18875.0" y="3353.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s57_shh1_shh2_sa51" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re28:(MAP:survival) PMID:18813803 s_shh2_re29:(MAP:survival) PMID:20678582 PMID:21034673 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Forkhead box P3 HUGO:FOXP3 HGNC:6106 ENTREZ:50943 UNIPROT:Q9BZS1 GENECARDS:FOXP3 KEGG:50943 ATLASONC:FOXP3ID44129chXp11 WIKI:FOXP3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20678582 PMID:21034673 References_end</body> </html> </notes> <label text="FOXP3"/> <bbox w="90.0" h="25.0" x="18841.0" y="3399.5"/> <glyph class="unit of information" id="_08947ec8-3aec-47a5-9c2e-eafde911472b"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18876.0" y="3394.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s59_shh1_shh2_sa53" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re32:(MAP:survival) PMID:18813803 s_shh2_re33:(MAP:survival) PMID:21285253 PMID:21346143 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Forkhead box Q1 HUGO:FOXQ1 HGNC:20951 ENTREZ:94234 UNIPROT:Q9C009 GENECARDS:FOXQ1 KEGG:94234 ATLASONC:GC_FOXQ1 WIKI:FOXQ1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21285253 PMID:21346143 References_end</body> </html> </notes> <label text="FOXQ1"/> <bbox w="90.0" h="25.0" x="18841.0" y="3445.5"/> <glyph class="unit of information" id="_b0105d40-ffca-4fca-b697-f3d9bea27ccc"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18876.0" y="3440.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s326_shh1_shh2_sa179" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re159:(MAP:survival) PMID:18077375 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: FUS1 HUGO:FUS HGNC:4010 ENTREZ:2521 UNIPROT:P35637 GENECARDS:FUS REACTOME:55036 KEGG:2521 ATLASONC:FUSID44 WIKI:FUS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17533367 References_end</body> </html> </notes> <label text="FUS"/> <clone/> <bbox w="90.0" h="25.0" x="20047.0" y="3932.5"/> <glyph class="unit of information" id="_81335bcc-e17b-4c9d-b20d-04ee494643eb"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="20082.0" y="3927.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s326_shh1_shh2_sa280" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re159:(MAP:survival) PMID:18077375 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: FUS1 HUGO:FUS HGNC:4010 ENTREZ:2521 UNIPROT:P35637 GENECARDS:FUS REACTOME:55036 KEGG:2521 ATLASONC:FUSID44 WIKI:FUS Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17533367 References_end</body> </html> </notes> <label text="FUS"/> <clone/> <bbox w="90.0" h="25.0" x="19546.0" y="4668.5"/> <glyph class="unit of information" id="_af62b86d-7bf9-4c48-a6f4-383719088863"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="19581.0" y="4663.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s84_shh1_shh2_sa78" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re51(MAP:survival): PMID:9216996 PMID:16413481 PMID:17000779 ANNOTATION: it was shown that Med12 binds to Gli1 promoter s_shh2_re163:(MAP:survival) PMID:16434164 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 1 HUGO:GLI1 HGNC:4317 ENTREZ:2735 UNIPROT:P08151 GENECARDS:GLI1 KEGG:2735 ATLASONC:GLIID310ch12q13 WIKI:GLI1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI1"/> <bbox w="90.0" h="25.0" x="18841.0" y="3717.5"/> <glyph class="unit of information" id="_4a668129-313e-4854-8066-8090cf7bb8c2"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18876.0" y="3712.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s86_shh1_shh2_sa80" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re52:(MAP:survival) PMID:16396903 s_shh2_re164:(MAP:survival) PMID:16434164 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 2 HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18497536 PMID:17845852 PMID:11001584 References_end</body> </html> </notes> <label text="GLI2"/> <bbox w="90.0" h="25.0" x="18841.0" y="3759.5"/> <glyph class="unit of information" id="_14423cd8-1712-4450-95df-90541d4b7500"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18876.0" y="3754.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s186_shh1_shh2_sa166" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re101:(MAP:survival) PMID:18057099 s_shh2_re165:(MAP:survival) PMID:16434164 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Gli family zinc finger 3 HUGO:GLI3 HGNC:4319 ENTREZ:2737 UNIPROT:P10071 GENECARDS:GLI3 KEGG:2737 ATLASONC:GC_GLI3 WIKI:GLI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI3"/> <bbox w="90.0" h="25.0" x="18841.0" y="4391.5"/> <glyph class="unit of information" id="_6439065d-5407-49f7-a254-9572d195ccba"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18876.0" y="4386.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s126_shh1_shh2_sa114" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re73:(MAP:survival) PMID:16571352 s_shh2_re161:(MAP:survival) PMID:10050855 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Hip1 HUGO:HHIP HGNC:14866 ENTREZ:64399 UNIPROT:Q96QV1 GENECARDS:HHIP KEGG:64399 ATLASONC:GC_HHIP WIKI:HHIP Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16571352 PMID:10050855 References_end</body> </html> </notes> <label text="HIP1*"/> <bbox w="90.0" h="25.0" x="18841.0" y="4056.5"/> <glyph class="unit of information" id="_176a60ec-87ae-4eb9-971b-ce6c31ebfce0"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18876.0" y="4051.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s261_shh1_shh2_sa230" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re132:(MAP:survival) PMID:21245165 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Harakiri Bcl2-interacting protein HUGO:HRK HGNC:5185 ENTREZ:8739 UNIPROT:O00198 GENECARDS:HRK KEGG:8739 ATLASONC:HRKID40865ch12q24 WIKI:HRK Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19641496 References_end</body> </html> </notes> <label text="HRK"/> <bbox w="90.0" h="25.0" x="19557.0" y="4254.5"/> <glyph class="unit of information" id="_fd7d76eb-de6b-4811-a4bc-1bc2d9e4810d"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="19592.0" y="4249.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s93_shh1_shh2_sa87" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re57:(MAP:survival) PMID:19736394 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Insuline-like growth factor binding protein 6 HUGO:IGFBP6 HGNC:5475 ENTREZ:3489 UNIPROT:P24592 GENECARDS:IGFBP6 REACTOME:381521 KEGG:3489 ATLASONC:GC_IGFBP6 WIKI:IGFBP6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19736394 References_end</body> </html> </notes> <label text="IGFBP6"/> <bbox w="90.0" h="25.0" x="18841.0" y="3971.5"/> <glyph class="unit of information" id="_3a892e18-226b-4d47-b7f2-c1fc3577325a"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18876.0" y="3966.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s150_shh1_shh2_sa136" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re86:(MAP:survival) PMID:19190345 PMID:16880536 s_shh2_re87(MAP:survival): Maps_Modules_end Identifiers_end s_shh2_re88:(MAP:survival) PMID:12606705 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Interleukin 1 receptor type II HUGO:IL1R2 HGNC:5994 ENTREZ:7850 UNIPROT:P27930 GENECARDS:IL1R2 REACTOME:57242 KEGG:7850 ATLASONC:GC_IL1R2 WIKI:IL1R2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:12606705 References_end</body> </html> </notes> <label text="IL1R2"/> <bbox w="90.0" h="25.0" x="18841.0" y="4216.5"/> <glyph class="unit of information" id="_5b744938-4802-43a4-9453-e9e5fe3144fc"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18876.0" y="4211.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s64_shh1_shh2_sa58" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re36:(MAP:survival) PMID:16880536 PMID:18813803 PMID:19190345 s_shh2_re37:(MAP:survival) PMID:19398556 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Jagged 2 HUGO:JAG2 HGNC:6189 ENTREZ:3714 UNIPROT:Q9Y219 GENECARDS:JAG2 REACTOME:57643 KEGG:3714 ATLASONC:JAG2ID41030ch14q32 WIKI:JAG2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19398556 References_end</body> </html> </notes> <label text="JAG2"/> <bbox w="90.0" h="25.0" x="18841.0" y="3535.5"/> <glyph class="unit of information" id="_97327133-a898-40d0-bee3-7816dce1c5e7"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18876.0" y="3530.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s143_shh1_shh2_sa130" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re82:(MAP:survival) PMID:19219074 s_shh2_re85:(MAP:survival) PMID:16977332 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Jun HUGO:JUN HGNC:6204 ENTREZ:3725 UNIPROT:P05412 GENECARDS:JUN REACTOME:50080 KEGG:3725 ATLASONC:JUNID151 WIKI:JUN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17439715 PMID:8545107 References_end</body> </html> </notes> <label text="JUN"/> <bbox w="90.0" h="25.0" x="18841.0" y="4180.5"/> <glyph class="unit of information" id="_7b08f48c-f5da-420e-acb6-0b4e1c99eb31"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18876.0" y="4175.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s188_shh1_shh2_sa168" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re102(MAP:survival): PMID:21442356 Not sure if direct interaction of gli1 with gene References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Matrix metallopeptidase 11 HUGO:MMP11 HGNC:7157 ENTREZ:4320 UNIPROT:P24347 GENECARDS:MMP11 REACTOME:59399 KEGG:4320 ATLASONC:ST3ID200 WIKI:MMP11 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16710861 PMID:15781316 References_end</body> </html> </notes> <label text="MMP11"/> <bbox w="90.0" h="25.0" x="18841.0" y="4425.5"/> <glyph class="unit of information" id="_36574b9d-036e-4731-be91-2821261e6b1c"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18876.0" y="4420.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s128_shh1_shh2_sa116" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re74:(MAP:survival) PMID:16054035 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: v-myc myelocytomatosis viral related oncogene neuroblastoma derived HUGO:MYCN HGNC:7559 ENTREZ:4613 UNIPROT:P04198 GENECARDS:MYCN KEGG:4613 ATLASONC:NMYC112 WIKI:MYCN Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:15061133 References_end</body> </html> </notes> <label text="MYCN"/> <bbox w="90.0" h="25.0" x="18841.0" y="4099.5"/> <glyph class="unit of information" id="_cc6dd023-747c-47a4-a02e-cb412fbbde77"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18876.0" y="4094.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s91_shh1_shh2_sa85" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re55:(MAP:survival) PMID:21059263 s_shh2_re56:(MAP:survival) PMID:19581346 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: NK2 Homeobox 2 HUGO:NKX2-2 HGNC:7835 ENTREZ:4821 UNIPROT:O95096 GENECARDS:NKX2-2 REACTOME:60235 KEGG:4821 ATLASONC:NKX22ID44177ch20p11 WIKI:NKX2-2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21169405 References_end</body> </html> </notes> <label text="NKX2-2"/> <bbox w="90.0" h="25.0" x="18841.0" y="3931.5"/> <glyph class="unit of information" id="_da2550cf-0a53-4017-9f80-8cf14256f5b6"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18876.0" y="3926.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s89_shh1_shh2_sa83" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re53:(MAP:survival) PMID:21059263 s_shh2_re54:(MAP:survival) PMID:19651775 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Paired box 6 HUGO:PAX6 HGNC:8620 ENTREZ:5080 UNIPROT:P26367 GENECARDS:PAX6 REACTOME:403472 KEGG:5080 ATLASONC:PAX6ID211ch11p13 WIKI:PAX6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:12970747 PMID:19651775 References_end</body> </html> </notes> <label text="PAX6"/> <bbox w="90.0" h="25.0" x="18841.0" y="3850.5"/> <glyph class="unit of information" id="_bf3cd11f-bf66-4099-aca4-f3d439319fac"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18876.0" y="3845.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s192_shh1_shh2_sa172" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re106:(MAP:survival) PMID:16169709 s_shh2_re107:(MAP:survival) PMID:18979497 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Paired box 9 HUGO:PAX9 HGNC:8623 ENTREZ:5083 UNIPROT:P55771 GENECARDS:PAX9 KEGG:5083 ATLASONC:PAX9ID41644ch14q12 WIKI:PAX9 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:12970747 PMID:18979497 References_end</body> </html> </notes> <label text="PAX9"/> <bbox w="90.0" h="25.0" x="18841.0" y="3891.5"/> <glyph class="unit of information" id="_f33e67ed-3a22-475a-b28f-8666b09357af"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18876.0" y="3886.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s75_shh1_shh2_sa69" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re45:(MAP:survival) PMID:15087129 s_shh2_re162:(MAP:survival) PMID:10021362 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Patched 1 HUGO:PTCH1 HGNC:9585 ENTREZ:5727 UNIPROT:Q13635 GENECARDS:PTCH1 REACTOME:62393 KEGG:5727 ATLASONC:PTCH100 WIKI:PTCH1 Patched 2 HUGO:PTCH2 HGNC:9586 ENTREZ:8643 UNIPROT:Q9Y6C5 GENECARDS:PTCH2 REACTOME:62395 KEGG:8643 ATLASONC:PTCH2ID41892ch1p34 WIKI:PTCH2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:10021362 PMID:17641202 References_end</body> </html> </notes> <label text="PTCH1"/> <bbox w="90.0" h="25.0" x="18841.0" y="3634.5"/> <glyph class="unit of information" id="_c1457346-bac2-411f-ad1d-6ca7ccfba891"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18876.0" y="3629.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s258_shh1_shh2_sa227" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re123:(MAP:survival) PMID:21359530 s_shh2_re158:(MAP:survival) PMID:18460397 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homo Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end Identifiers_begin: phosphatase and tensin homolog HUGO:PTEN HGNC:9588 ENTREZ:5728 UNIPROT:P60484 GENECARDS:PTEN REACTOME:62405 KEGG:5728 ATLASONC:PTENID158 WIKI:PTEN phosphatase and tensin homo Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 PMID:17218262 References_end</body> </html> </notes> <label text="PTEN"/> <bbox w="90.0" h="25.0" x="19549.0" y="3982.5"/> <glyph class="unit of information" id="_ff74ccc1-964f-4afb-9abc-f18177a0e846"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="19584.0" y="3977.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s61_shh1_shh2_sa55" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re34:(MAP:survival) PMID:18813803 s_shh2_re35:(MAP:survival) PMID:20946121 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Runt-related transcription factor 2 HUGO:RUNX2 HGNC:10472 ENTREZ:860 UNIPROT:Q13950 GENECARDS:RUNX2 REACTOME:63858 KEGG:860 ATLASONC:RUNX2ID42183ch6p21 WIKI:RUNX2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20946121 PMID:20580290 References_end</body> </html> </notes> <label text="RUNX2"/> <bbox w="90.0" h="25.0" x="18841.0" y="3492.5"/> <glyph class="unit of information" id="_91f03f03-16ea-4f8b-bee6-94a686f672f3"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18876.0" y="3487.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s167_shh1_shh2_sa149" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re94:(MAP:survival) PMID:16880536 s_shh2_re96:(MAP:survival) PMID:15994944 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: S100 calcium binding protein A7 HUGO:S100A7 HGNC:10497 ENTREZ:6278 UNIPROT:P31151 GENECARDS:S100A7 KEGG:6278 ATLASONC:S100A7ID42194ch1q21 WIKI:S100A7 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21228116 References_end</body> </html> </notes> <label text="S100A7"/> <bbox w="90.0" h="25.0" x="18841.0" y="4287.5"/> <glyph class="unit of information" id="_22d3349e-4220-43aa-9a76-bae70335026c"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18876.0" y="4282.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s165_shh1_shh2_sa147" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re91:(MAP:survival) PMID:19190345 PMID:16880536 s_shh2_re92:(MAP:survival) PMID:21228116 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: S100 calcium binding protein A9 HUGO:S100A9 HGNC:10499 ENTREZ:6280 UNIPROT:P06702 GENECARDS:S100A9 KEGG:6280 ATLASONC:S100A9ID45569ch1q21 WIKI:S100A9 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21228116 References_end</body> </html> </notes> <label text="S100A9"/> <bbox w="90.0" h="25.0" x="18841.0" y="4253.5"/> <glyph class="unit of information" id="_c48afcdd-6d63-433c-9e30-862b83fcdc7b"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18876.0" y="4248.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s40_shh1_shh2_sa34" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re15:(MAP:survival) PMID:17035233 PMID:16328026 s_shh2_re16:(MAP:survival) PMID:16328026 PMID:17035233 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Secreted frizzled-related protein 1 HUGO:SFRP1 HGNC:10776 ENTREZ:6422 UNIPROT:Q8N474 GENECARDS:SFRP1 KEGG:6422 ATLASONC:GC_SFRP1 WIKI:SFRP1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20448436 References_end</body> </html> </notes> <label text="SFRP1"/> <bbox w="90.0" h="25.0" x="18840.0" y="3078.5"/> <glyph class="unit of information" id="_409d7e67-604c-40f2-b35c-1cba868b36b9"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18875.0" y="3073.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s82_shh1_shh2_sa76" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re49:(MAP:survival) PMID:20143239 PMID:16413481 s_shh2_re50:(MAP:survival) PMID:19055944 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Six homeobox 1 HUGO:SIX1 HGNC:10887 ENTREZ:6495 UNIPROT:Q15475 GENECARDS:SIX1 KEGG:6495 ATLASONC:SIX1ID42302ch14q23 WIKI:SIX1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11003839 References_end</body> </html> </notes> <label text="SIX1"/> <bbox w="90.0" h="25.0" x="18841.0" y="3674.5"/> <glyph class="unit of information" id="_ae6b87a7-c9fa-491a-8c11-2d672685f953"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18876.0" y="3669.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s130_shh1_shh2_sa118" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re77:(MAP:survival) PMID:16158046 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Snail homologue 1 HUGO:SNAI1 HGNC:11128 ENTREZ:6615 UNIPROT:O95863 GENECARDS:SNAI1 KEGG:6615 ATLASONC:SNAI1ID452ch20q13 WIKI:SNAI1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:EMT_REGULATORS MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20713713 References_end</body> </html> </notes> <label text="SNAI1"/> <bbox w="90.0" h="25.0" x="18841.0" y="4141.5"/> <glyph class="unit of information" id="_e470376c-5d42-48d3-a364-e94e586adea6"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18876.0" y="4136.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s305_shh1_shh2_sa264" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re152:(MAP:survival) PMID:21383238 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: signal transducer and activator of transcription 3 HUGO:STAT3 HGNC:11364 ENTREZ:6774 UNIPROT:P40763 GENECARDS:STAT3 REACTOME:403956 KEGG:6774 ATLASONC:STAT3ID444 WIKI:STAT3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19424782 References_end</body> </html> </notes> <label text="STAT3"/> <bbox w="90.0" h="25.0" x="19552.0" y="4511.5"/> <glyph class="unit of information" id="_c9f4bd46-9070-4992-82e8-1953dffe48dd"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="19587.0" y="4506.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s199_shh1_shh2_sa178" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re160:(MAP:survival) PMID:18077375 References_end</body> </html> </notes> <label text="SUFU"/> <bbox w="90.0" h="25.0" x="19783.0" y="3932.5"/> <glyph class="unit of information" id="_79177a92-483a-482a-80c4-f1f14aaf8f1c"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="19818.0" y="3927.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s327_shh1_shh2_sa281" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <label text="SUFU"/> <bbox w="90.0" h="25.0" x="19546.0" y="4706.5"/> <glyph class="unit of information" id="_75ed53a3-af3f-4180-a123-2549d62031f2"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="19581.0" y="4701.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s73_shh1_shh2_sa67" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re43:(MAP:survival) PMID:9609833 PMID:16413481 s_shh2_re44:(MAP:survival) PMID:20348948 PMID:19960541 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: T-box 2 HUGO:TBX2 HGNC:11597 ENTREZ:6909 UNIPROT:Q13207 GENECARDS:TBX2 ATLASONC:TBX2ID42485ch17q23 WIKI:TBX2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20567632 PMID:19960541 References_end</body> </html> </notes> <label text="TBX2"/> <bbox w="90.0" h="25.0" x="18841.0" y="3586.5"/> <glyph class="unit of information" id="_b3e887f9-2c12-4c7e-b72d-431a352c888f"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18876.0" y="3581.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s318_shh1_shh2_sa274" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re156:(MAP:survival) PMID:21271217 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: TNF-alpha HUGO:TNF HGNC:11892 ENTREZ:7124 UNIPROT:P01375 GENECARDS:TNF REACTOME:66221 KEGG:7124 ATLASONC:TNFaID319 WIKI:TNF Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21555371 References_end</body> </html> </notes> <label text="TNF-α*"/> <bbox w="90.0" h="25.0" x="19546.0" y="4595.5"/> <glyph class="unit of information" id="_f086e069-3c70-4d69-b95c-90ef20f243fc"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="19581.0" y="4590.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s300_shh1_shh2_sa260" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re149(MAP:survival): PMID:16878133 PMID:18550634 Not known which miRNA of the miR-17-92 polycistron is reponsible for degradation of Tsp1 and CTGF not known which miRNA is responsible therefor miR-17-3p is shown in complex References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: thrombospondin 1 HUGO:THBS1 HGNC:11785 ENTREZ:7057 UNIPROT:P07996 GENECARDS:THBS1 REACTOME:66519 KEGG:7057 ATLASONC:THBS1ID42548ch15q15 WIKI:THBS1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18193162 References_end</body> </html> </notes> <label text="TSP1*"/> <bbox w="90.0" h="25.0" x="19552.0" y="4436.5"/> <glyph class="unit of information" id="_3530f4ef-7d67-4672-8682-ec34dc854973"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="19587.0" y="4431.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s174_shh1_shh2_sa156" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re99:(MAP:survival) PMID:19190345 PMID:16880536 s_shh2_re100:(MAP:survival) PMID:19211835 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Unc-51-like kinase 1 HUGO:ULK1 HGNC:12558 ENTREZ:8408 UNIPROT:O75385 GENECARDS:ULK1 KEGG:8408 ATLASONC:GC_ULK1 WIKI:ULK1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20056399 References_end</body> </html> </notes> <label text="ULK1"/> <bbox w="90.0" h="25.0" x="18841.0" y="4356.5"/> <glyph class="unit of information" id="_010ab59f-6bd3-424f-9a98-9958807ddf0e"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18876.0" y="4351.5"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s_shh2_s190_shh1_shh2_sa170" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re104:(MAP:survival) PMID:19809516 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Wingless-type MMTV integration site family member 11 HUGO:WNT11 HGNC:12776 ENTREZ:7481 UNIPROT:O96014 GENECARDS:WNT11 REACTOME:67348 KEGG:7481 ATLASONC:GC_WNT11 WIKI:WNT11 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21447091 References_end</body> </html> </notes> <label text="WNT11"/> <bbox w="90.0" h="25.0" x="18841.0" y="4463.5"/> <glyph class="unit of information" id="_498ea0b4-5ec7-4867-b33f-77a82e2e7905"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="18876.0" y="4458.5"/> </glyph> </glyph> <glyph class="phenotype" id="shh1_s_shh2_s20_shh1_shh2_sa16" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh2_re5:(MAP:survival) PMID:19736394 References_end</body> </html> </notes> <label text="Trail pathway"/> <bbox w="80.0" h="30.0" x="19137.0" y="2997.0"/> </glyph> <glyph class="simple chemical" id="shh1_s_shh3_s3_shh1_shh3_sa3" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end</body> </html> </notes> <label text="Ligand"/> <bbox w="70.0" h="25.0" x="19449.0" y="4958.5"/> </glyph> <glyph class="simple chemical" id="shh1_s_shh3_s97_shh1_shh3_sa67" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end</body> </html> </notes> <label text="PI3,4,5-P3"/> <bbox w="70.0" h="25.0" x="19947.0" y="4953.5"/> </glyph> <glyph class="simple chemical" id="shh1_s_shh3_s112_shh1_shh3_sa81" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end</body> </html> </notes> <label text="PI3,4,5-P3"/> <bbox w="70.0" h="25.0" x="20309.5" y="4957.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh3_s73_shh1_shh3_sa48" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Smoothened HUGO:SMO HGNC:11119 ENTREZ:6608 UNIPROT:Q99835 GENECARDS:SMO REACTOME:64670 KEGG:6608 ATLASONC:GC_SMO WIKI:SMO Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18820483 PMID:17641202 Smoothened homologue (Drosophila) References_end</body> </html> </notes> <label text="SMO"/> <bbox w="80.0" h="40.0" x="18604.5" y="5221.0"/> <glyph class="state variable" id="_ebb6d1e4-d924-41a1-b417-5ccfbe348dd3"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="18677.0" y="5216.0"/> </glyph> <glyph class="state variable" id="_6e2b9d29-c771-42b0-8239-94b8a3bfed6a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18679.5" y="5216.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh3_s86_shh1_shh3_sa59" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re14:(MAP:survival) PMID:17549397 s_shh3_re12(MAP:survival): PMID:17549397 PMID:19082481 PMID:11801735 PMID:12514186 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Fes HUGO:FES HGNC:3657 ENTREZ:2242 UNIPROT:P07332 GENECARDS:FES REACTOME:54750 KEGG:2242 ATLASONC:GC_FES WIKI:FES Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17549397 PMID:19082481 PMID:11801735 PMID:12514186 References_end</body> </html> </notes> <label text="C-FES*"/> <bbox w="80.0" h="40.0" x="19279.5" y="5413.0"/> <glyph class="state variable" id="_04efdff8-89fa-428e-95eb-5c33f8854ace"> <state value="P" variable="Y713"/> <bbox w="35.0" h="10.0" x="19262.492" y="5408.0"/> </glyph> <glyph class="state variable" id="_bb027fbc-c645-42b1-bb55-c78791885783"> <state value="P" variable="Y811"/> <bbox w="35.0" h="10.0" x="19342.0" y="5408.215"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="shh1_s_shh3_s88_shh1_shh3_sa60" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re12(MAP:survival): PMID:17549397 PMID:19082481 PMID:11801735 PMID:12514186 s_shh3_re15(MAP:survival): References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Fes HUGO:FES HGNC:3657 ENTREZ:2242 UNIPROT:P07332 GENECARDS:FES REACTOME:54750 KEGG:2242 ATLASONC:GC_FES WIKI:FES Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17549397 PMID:19082481 PMID:11801735 PMID:12514186 References_end</body> </html> </notes> <label text="C-FES*"/> <bbox w="86.0" h="46.0" x="19429.5" y="5413.0"/> <glyph class="unit of information" id="_bd741339-05ca-457a-a4b2-c525f54d2913"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="19462.5" y="5408.0"/> </glyph> <glyph class="state variable" id="_d9043764-f652-4636-aba3-8bcfbdd3ba54"> <state value="P" variable="Y713"/> <bbox w="35.0" h="10.0" x="19412.53" y="5408.0"/> </glyph> <glyph class="state variable" id="_e154acb7-3498-4222-b884-e0dc224190fe"> <state value="P" variable="Y811"/> <bbox w="35.0" h="10.0" x="19498.0" y="5408.247"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh3_s98_shh1_shh3_sa68" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: T-cell lymphoma invasion and metastasis 1 HUGO:TIAM1 HGNC:11805 ENTREZ:7074 UNIPROT:Q13009 GENECARDS:TIAM1 REACTOME:195051 ATLASONC:TIAM1ID42557ch21q22 WIKI:TIAM1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:12829230 References_end</body> </html> </notes> <label text="TIAM1"/> <bbox w="80.0" h="40.0" x="19941.0" y="5006.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh3_s118_shh1_shh3_sa87" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_akt1_re44:(MAP:survival) PMID:16464865 s_shh3_re24:(MAP:survival) PMID:15611338 s_akt1_re45(MAP:survival): PMID:14551205 PMID:17693255 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 GENECARDS:TSC2 REACTOME:404219 KEGG:7249 ATLASONC:TSC2ID184 WIKI:TSC2 P49815 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 GENECARDS:TSC2 REACTOME:404219 KEGG:7249 ATLASONC:TSC2ID184 WIKI:TSC2 P49815 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end</body> </html> </notes> <label text="TSC2"/> <bbox w="80.0" h="40.0" x="19918.0" y="5459.0"/> <glyph class="state variable" id="_609be265-72bc-4de1-8cb5-fb71e93a4f27"> <state value="" variable="S1086"/> <bbox w="35.0" h="10.0" x="19980.5" y="5475.4663"/> </glyph> <glyph class="state variable" id="_0ccdab19-79ea-42a8-bda2-4dd2b4652230"> <state value="" variable="S981"/> <bbox w="30.0" h="10.0" x="19979.582" y="5454.0"/> </glyph> <glyph class="state variable" id="_240b39b4-1339-4426-8487-74968233f2e1"> <state value="" variable="S1130"/> <bbox w="35.0" h="10.0" x="19938.402" y="5494.0"/> </glyph> <glyph class="state variable" id="_811b8469-452c-4bb2-aa81-fee40c6562e2"> <state value="" variable="T1462"/> <bbox w="35.0" h="10.0" x="19900.992" y="5454.0"/> </glyph> <glyph class="state variable" id="_534054f5-81f2-4cbb-bcdb-50349087ca69"> <state value="" variable="S1132"/> <bbox w="35.0" h="10.0" x="19900.5" y="5492.9487"/> </glyph> <glyph class="state variable" id="_b76668c6-7838-4113-95ca-93078b90d46c"> <state value="" variable="S939"/> <bbox w="30.0" h="10.0" x="19941.03" y="5454.0"/> </glyph> <glyph class="state variable" id="_35cdf06a-28d7-4cf1-bae2-cf94b8b00b3e"> <state value="" variable="S1088"/> <bbox w="35.0" h="10.0" x="19979.88" y="5494.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh3_s119_shh1_shh3_sa88" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re19(MAP:survival): PMID:12829230 PMID:11955434 PMID:15967165 PMID:15611338 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: tuberous sclerosis 1 HUGO:TSC1 HGNC:12362 ENTREZ:7248 UNIPROT:Q92574 GENECARDS:TSC1 REACTOME:66499 KEGG:7248 ATLASONC:TSC1ID183 WIKI:TSC1 Q92574 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end Identifiers_begin: tuberous sclerosis 1 HUGO:TSC1 HGNC:12362 ENTREZ:7248 UNIPROT:Q92574 GENECARDS:TSC1 REACTOME:66499 KEGG:7248 ATLASONC:TSC1ID183 WIKI:TSC1 Q92574 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end</body> </html> </notes> <label text="TSC1"/> <bbox w="80.0" h="40.0" x="19918.0" y="5376.0"/> <glyph class="state variable" id="_06be6d07-2f85-4d26-8748-378c66a3617e"> <state value="" variable="T417"/> <bbox w="30.0" h="10.0" x="19903.492" y="5371.0"/> </glyph> <glyph class="state variable" id="_5ae17b5b-e586-4dec-8a2b-c73a8c804462"> <state value="" variable="S487"/> <bbox w="30.0" h="10.0" x="19983.0" y="5371.215"/> </glyph> <glyph class="state variable" id="_ec048af7-88a0-4557-b7fd-43977ad7db24"> <state value="" variable="S584"/> <bbox w="30.0" h="10.0" x="19980.086" y="5411.0"/> </glyph> <glyph class="state variable" id="_95d2a174-d141-46e3-a3a5-262661a1a1e7"> <state value="" variable="T1047"/> <bbox w="35.0" h="10.0" x="19900.5" y="5410.722"/> </glyph> <glyph class="state variable" id="_e5bc5398-aee1-4821-a036-065eba42e45f"> <state value="" variable="S511"/> <bbox w="30.0" h="10.0" x="19983.0" y="5391.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s_shh3_s125_shh1_shh3_sa96" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re26:(MAP:survival) PMID:19465923 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Four and half LIM domains 2, Dral HUGO:FHL2 HGNC:3703 ENTREZ:2274 UNIPROT:Q14192 GENECARDS:FHL2 REACTOME:64554 KEGG:2274 ATLASONC:FHL2ID44092ch2q12 WIKI:FHL2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19465923 References_end</body> </html> </notes> <label text="DRAL*"/> <bbox w="80.0" h="40.0" x="19543.5" y="5068.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh3_s126_shh1_shh3_sa97" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re26:(MAP:survival) PMID:19465923 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Caspase recruitment domain family 8 HUGO:CARD8 HGNC:17057 ENTREZ:22900 UNIPROT:Q9Y2G2 GENECARDS:CARD8 KEGG:22900 ATLASONC:CARD8ID913ch19q13 WIKI:CARD8 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19465923 References_end</body> </html> </notes> <label text="TUCAN*"/> <bbox w="80.0" h="40.0" x="19543.5" y="5109.0"/> </glyph> <glyph class="macromolecule" id="shh1_s_shh3_s127_shh1_shh3_sa98" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re26:(MAP:survival) PMID:19465923 s_mpk1_re32(MAP:survival): Caspase9 is phosphorylated on Thr125 in a MEK1/2-dependent manner in vivo. Furthermore caspase9 is efficiently phosphorylated on Thr125 by ERK in vitro suggesting that it is targeted directly by ERK in vivo. This is one of the ways ERK plays its anti-apoptotic role. PMID:12792650 s_mpk1_re34(MAP:survival): Activated caspase-9 cleaves and activates caspase-3 leading to apoptosis. PMID:9390557 s_akt1_re132(MAP:survival): PMID:19788417 PMID:16977332 s_akt1_re134:(MAP:survival) PMID:9812896 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: caspase 9 apoptosis-related cysteine peptidase "caspase 9 apoptosis-related cysteine protease" HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Caspase9 is phosphorylated on Thr125 in a MEK1/2-dependent manner in vivo. Furthermore caspase9 is efficiently phosphorylated on Thr125 by ERK in vitro suggesting that it is targeted directly by ERK in vivo. This is one of the ways ERK plays its anti-apoptotic role. PMID:12792650 References_end Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 GENECARDS:CASP9 REACTOME:57034 KEGG:842 ATLASONC:CASP9ID423ch1p36 WIKI:CASP9 "caspase 9 apoptosis-related cysteine protease" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19788417 PMID:16977332 Caspase9 is phosphorylated on Thr125 in a MEK1/2-dependent manner in vivo. Furthermore caspase9 is efficiently phosphorylated on Thr125 by ERK in vitro suggesting that it is targeted directly by ERK in vivo. This is one of the ways ERK plays its anti-apoptotic role. PMID:12792650 References_end Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 GENECARDS:CASP9 REACTOME:57034 KEGG:842 ATLASONC:CASP9ID423ch1p36 WIKI:CASP9 "caspase 9 apoptosis-related cysteine protease" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19788417 PMID:16977332 Caspase9 is phosphorylated on Thr125 in a MEK1/2-dependent manner in vivo. Furthermore caspase9 is efficiently phosphorylated on Thr125 by ERK in vitro suggesting that it is targeted directly by ERK in vivo. This is one of the ways ERK plays its anti-apoptotic role. PMID:12792650 References_end</body> </html> </notes> <label text="Caspase9*"/> <bbox w="80.0" h="40.0" x="19543.5" y="5150.0"/> <glyph class="state variable" id="_4e9d9ed1-8cec-401d-98fe-9380c674391c"> <state value="" variable="S196"/> <bbox w="30.0" h="10.0" x="19608.5" y="5145.991"/> </glyph> <glyph class="state variable" id="_31aca3af-7d9a-4300-bbd3-ad075677ddc2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19538.5" y="5165.0"/> </glyph> </glyph> <glyph class="phenotype" id="shh1_s_shh3_s117_shh1_shh3_sa86" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re23(MAP:survival): PMID:15901767 PMID:20595387 s_wnc1_re75:(MAP:survival) PMID:19577357 s_wnc2_re23(MAP:survival): Calpain might be involved in EMT as it can proteolyse many proteins that are involved in cell adhesion. PMID:16129881 References_end</body> </html> </notes> <label text="EMT"/> <bbox w="80.0" h="30.0" x="20198.0" y="5542.0"/> </glyph> <glyph class="phenotype" id="shh1_s_shh3_s77_shh1_shh3_sa51" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end</body> </html> </notes> <label text="Sonic hedgehog pathway"/> <bbox w="80.0" h="30.0" x="18788.0" y="5225.0"/> </glyph> <glyph class="complex" id="shh1_s_shh3_s6_shh1_shh3_csa1" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Ligand:PTCH* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re2(MAP:survival): PMID:16885213 PMID:18815277 References_end</body> </html> </notes> <label text="Ptc_HH_ligand"/> <bbox w="104.0" h="152.0" x="19328.0" y="4890.0"/> <glyph class="macromolecule" id="shh1_shh3_s10_shh1_shh3_sa4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Patched 1 HUGO:PTCH1 HGNC:9585 ENTREZ:5727 UNIPROT:Q13635 GENECARDS:PTCH1 REACTOME:62393 KEGG:5727 ATLASONC:PTCH100 WIKI:PTCH1 Patched 2 HUGO:PTCH2 HGNC:9586 ENTREZ:8643 UNIPROT:Q9Y6C5 GENECARDS:PTCH2 REACTOME:62395 KEGG:8643 ATLASONC:PTCH2ID41892ch1p34 WIKI:PTCH2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:10021362 PMID:17641202 References_end</body> </html> </notes> <label text="PTCH*"/> <bbox w="78.0" h="114.0" x="19343.5" y="4906.0"/> <glyph class="unit of information" id="_e4d7af0e-d36f-4747-9e97-0b09b95d2c31"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="19360.0" y="4901.0"/> </glyph> </glyph> <glyph class="simple chemical" id="shh1_shh3_s11_shh1_shh3_sa5"> <label text="Ligand"/> <bbox w="70.0" h="25.0" x="19346.5" y="4894.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh3_s16_shh1_shh3_csa5" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GDP:G_alpha__sub_i_endsub_*:G_beta_*:G_gamma_*:HH Ligand:PTCH*:SMO Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re2(MAP:survival): PMID:16885213 PMID:18815277 s_shh3_re5(MAP:survival): PMID:17430994 PMID:21474452 PMID:20081366 References_end</body> </html> </notes> <label text="Ptc_HH_ligand_Smo"/> <bbox w="340.0" h="179.0" x="18190.5" y="4918.5"/> <glyph class="macromolecule" id="shh1_shh3_s43_shh1_shh3_sa28"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Patched 1 HUGO:PTCH1 HGNC:9585 ENTREZ:5727 UNIPROT:Q13635 GENECARDS:PTCH1 REACTOME:62393 KEGG:5727 ATLASONC:PTCH100 WIKI:PTCH1 Patched 2 HUGO:PTCH2 HGNC:9586 ENTREZ:8643 UNIPROT:Q9Y6C5 GENECARDS:PTCH2 REACTOME:62395 KEGG:8643 ATLASONC:PTCH2ID41892ch1p34 WIKI:PTCH2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:10021362 PMID:17641202 References_end</body> </html> </notes> <label text="PTCH*"/> <bbox w="78.0" h="114.0" x="18442.0" y="4934.5"/> <glyph class="unit of information" id="_d29986d7-6d2c-4d0b-86e0-c691de5a831c"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="18458.5" y="4929.5"/> </glyph> </glyph> <glyph class="simple chemical" id="shh1_shh3_s54_shh1_shh3_sa29"> <label text="Ligand"/> <bbox w="70.0" h="25.0" x="18445.0" y="4922.5"/> </glyph> <glyph class="macromolecule" id="shh1_shh3_s45_shh1_shh3_sa30"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Smoothened HUGO:SMO HGNC:11119 ENTREZ:6608 UNIPROT:Q99835 GENECARDS:SMO REACTOME:64670 KEGG:6608 ATLASONC:GC_SMO WIKI:SMO Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18820483 PMID:17641202 Smoothened homologue (Drosophila) References_end</body> </html> </notes> <label text="SMO"/> <bbox w="80.0" h="40.0" x="18360.5" y="4963.5"/> <glyph class="state variable" id="_68eb4b3e-3d1b-4850-90e5-5088e5e6877d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18435.5" y="4958.5"/> </glyph> <glyph class="state variable" id="_82dee022-0848-4be9-9333-a59cd53ac980"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18435.5" y="4958.5"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh3_s46_shh1_shh3_sa31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 Guanine nucleotide binding protein (G-protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 Guanine nucleotide binding protein (G-protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17430994 Guanine nucleotide binding protein (G-protein) References_end</body> </html> </notes> <label text="Gαi*"/> <bbox w="80.0" h="40.0" x="18199.5" y="5010.5"/> </glyph> <glyph class="macromolecule" id="shh1_shh3_s47_shh1_shh3_sa32"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="80.0" h="40.0" x="18280.5" y="5009.5"/> </glyph> <glyph class="macromolecule" id="shh1_shh3_s48_shh1_shh3_sa33"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="80.0" h="40.0" x="18362.5" y="5009.5"/> </glyph> <glyph class="simple chemical" id="shh1_shh3_s107_shh1_shh3_sa75"> <label text="GTP"/> <bbox w="30.0" h="30.0" x="18224.5" y="5051.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh3_s60_shh1_shh3_csa6" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GTP:G_alpha__sub_i_endsub_* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end</body> </html> </notes> <label text="Gi_protein_GTP"/> <bbox w="100.0" h="120.0" x="18079.0" y="5182.0"/> <glyph class="macromolecule" id="shh1_shh3_s63_shh1_shh3_sa40"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 Guanine nucleotide binding protein (G-protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 Guanine nucleotide binding protein (G-protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17430994 Guanine nucleotide binding protein (G-protein) References_end</body> </html> </notes> <label text="Gαi*"/> <bbox w="80.0" h="40.0" x="18089.5" y="5192.0"/> </glyph> <glyph class="simple chemical" id="shh1_shh3_s108_shh1_shh3_sa76"> <label text="GTP"/> <bbox w="30.0" h="30.0" x="18114.5" y="5235.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh3_s61_shh1_shh3_csa7" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:G_beta_*:G_gamma_* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re6:(MAP:survival) PMID:17430994 s_wca1_re28(MAP:survival): PMID:20006983 PMID:16965538 PMID:210606194 PMID:20093472 PMID:21796133 Phosphorylation of DVL by CK1 epsilon. Activation of CK1 epsilon by unknown factor An acidic environment is required for phosphorylation of DVL and LRP5/6 s_wnc1_re50:(MAP:survival) PMID:20628572 s_wnc1_re64(MAP:survival): For the Fzl receptor, probably same mechanism as for the canonical MODULE. CK1 epsilon is activated upon Wnt-5 stimulation, however, the mechanism is unknown. PMID:17244647 PMID:20215527 s_shh3_re7(MAP:survival): PMID:12764189 PMID:18815277 s_shh3_re10(MAP:survival): PMID:12297047 PMID:16847462 s_wca1_re29(MAP:survival): PMID:19705439 PMID:17426148 Beta-ARRESTIN binds to phosphorylated DVL s_wca1_re33(MAP:survival): PMID:19561074 PMID:20460648 PMID:19581931 PMID:21304492 PMID:21498506 AMER1 recruits axin s_wnc1_re29:(MAP:survival) PMID:12747838 s_wnc1_re31:(MAP:survival) PMID:21736902 s_wnc1_re54:(MAP:survival) PMID:10999941 s_wnc1_re57(MAP:survival): PLC-beta_2 and 3 are activated by the beta-and gamma subunit of the G-protein class q PMID:20553968 References_end</body> </html> </notes> <label text="Giβgamma_dimer"/> <bbox w="100.0" h="120.0" x="18251.0" y="5182.0"/> <glyph class="macromolecule" id="shh1_shh3_s65_shh1_shh3_sa41"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="80.0" h="40.0" x="18263.0" y="5235.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh3_s66_shh1_shh3_sa42"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="80.0" h="40.0" x="18263.0" y="5193.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh3_s69_shh1_shh3_csa8" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GRK*:G_beta_*:G_gamma_* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re7(MAP:survival): PMID:12764189 PMID:18815277 s_shh3_re8(MAP:survival): PMID:16885213 References_end</body> </html> </notes> <label text="Grk_Giβgamma_dimer"/> <bbox w="103.0" h="163.0" x="18505.0" y="5342.0"/> <glyph class="macromolecule" id="shh1_shh3_s68_shh1_shh3_sa44"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: adrenergic beta receptor kinase 1 HUGO:ADRBK1 HGNC:289 ENTREZ:156 UNIPROT:P25098 adrenergic beta receptor kinase 2 HUGO:ADRBK2 HGNC:290 ENTREZ:157 UNIPROT:P35626 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN. PMID:11226259 References_end Identifiers_begin: G protein-coupled receptor kinase 1 HUGO:GRK1 HGNC:10013 ENTREZ:6011 UNIPROT:Q15835 GENECARDS:GRK1 KEGG:6011 ATLASONC:GC_GRK1 WIKI:GRK1 G protein-coupled receptor kinase 4 HUGO:GRK4 HGNC:4543 ENTREZ:2868 UNIPROT:P32298 GENECARDS:GRK4 KEGG:2868 ATLASONC:GC_GRK4 WIKI:GRK4 G protein-coupled receptor kinase 5 HUGO:GRK5 HGNC:4544 ENTREZ:2869 UNIPROT:P34947 GENECARDS:GRK5 REACTOME:55956 KEGG:2869 WIKI:GRK5 G protein-coupled receptor kinase 6 HUGO:GRK6 HGNC:4545 ENTREZ:2870 UNIPROT:P43250 GENECARDS:GRK6 KEGG:2870 ATLASONC:GC_GRK6 WIKI:GRK6 G protein-coupled receptor kinase 7 HUGO:GRK7 HGNC:17031 ENTREZ:131890 UNIPROT:Q8WTQ7 GENECARDS:GRK7 KEGG:131890 WIKI:GRK7 adrenergic beta receptor kinase 1 HUGO:ADRBK1 HGNC:289 ENTREZ:156 UNIPROT:P25098 GENECARDS:ADRBK1 REACTOME:50271 KEGG:156 ATLASONC:GC_ADRBK1 WIKI:ADRBK1 adrenergic beta receptor kinase 2 HUGO:ADRBK2 HGNC:290 ENTREZ:157 UNIPROT:P35626 GENECARDS:ADRBK2 KEGG:157 ATLASONC:GC_ADRBK2 WIKI:ADRBK2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK Maps_Modules_end References_begin: PMID:16525728 PMID:15618519 Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN. PMID:11226259 References_end</body> </html> </notes> <label text="GRK*"/> <bbox w="80.0" h="40.0" x="18517.5" y="5354.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh3_s70_shh1_shh3_sa45"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="80.0" h="40.0" x="18517.25" y="5397.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh3_s71_shh1_shh3_sa46"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="80.0" h="40.0" x="18517.25" y="5440.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh3_s94_shh1_shh3_csa12" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:C-FES*:p110*:p85* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re15(MAP:survival): PMID:11801735 PMID:19082481 References_end</body> </html> </notes> <label text="c-Fes_PI3K"/> <bbox w="103.0" h="159.0" x="19505.0" y="5603.0"/> <glyph class="macromolecule" id="shh1_shh3_s90_shh1_shh3_sa61"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: phosphoinositide-3-kinase, regulatory subunit 1 (alpha) HUGO:PIK3R1 HGNC:8979 ENTREZ:5295 UNIPROT:P27986 GENECARDS:PIK3R1 REACTOME:61192 KEGG:5295 ATLASONC:PIK3R1ID41717ch5q13 WIKI:PIK3R1 phosphoinositide-3-kinase, regulatory subunit 2 (beta) HUGO:PIK3R2 HGNC:8980 ENTREZ:5296 UNIPROT:O00459 GENECARDS:PIK3R2 REACTOME:61194 KEGG:5296 ATLASONC:GC_PIK3R2 WIKI:PIK3R2 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) HUGO:PIK3R3 HGNC:8981 ENTREZ:8503 UNIPROT:Q92569 GENECARDS:PIK3R3 REACTOME:61182 KEGG:8503 ATLASONC:GC_PIK3R3 WIKI:PIK3R3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 PMID:19568798 PMID:12040186 References_end Identifiers_begin: phosphoinositide-3-kinase, regulatory subunit 1 (alpha) HUGO:PIK3R1 HGNC:8979 ENTREZ:5295 UNIPROT:P27986 GENECARDS:PIK3R1 REACTOME:61192 KEGG:5295 ATLASONC:PIK3R1ID41717ch5q13 WIKI:PIK3R1 phosphoinositide-3-kinase, regulatory subunit 2 (beta) HUGO:PIK3R2 HGNC:8980 ENTREZ:5296 UNIPROT:O00459 GENECARDS:PIK3R2 REACTOME:61194 KEGG:5296 ATLASONC:GC_PIK3R2 WIKI:PIK3R2 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) HUGO:PIK3R3 HGNC:8981 ENTREZ:8503 UNIPROT:Q92569 GENECARDS:PIK3R3 REACTOME:61182 KEGG:8503 ATLASONC:GC_PIK3R3 WIKI:PIK3R3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 PMID:19568798 PMID:12040186 References_end</body> </html> </notes> <label text="p85*"/> <bbox w="80.0" h="40.0" x="19516.0" y="5611.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh3_s91_shh1_shh3_sa62"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: phosphoinositide-3-kinase, catalytic, alpha polypeptide HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 GENECARDS:PIK3CA REACTOME:61074 KEGG:5290 ATLASONC:PIK3CAID415ch3q26 WIKI:PIK3CA phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, delta polypeptide HUGO:PIK3CD HGNC:8977 ENTREZ:5293 UNIPROT:O00329 GENECARDS:PIK3CD REACTOME:61078 KEGG:5293 ATLASONC:PIK3CDID46261ch1p36 WIKI:PIK3CD phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 References_end</body> </html> Identifiers_begin: phosphoinositide-3-kinase, catalytic, alpha polypeptide HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 GENECARDS:PIK3CA REACTOME:61074 KEGG:5290 ATLASONC:PIK3CAID415ch3q26 WIKI:PIK3CA phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, delta polypeptide HUGO:PIK3CD HGNC:8977 ENTREZ:5293 UNIPROT:O00329 GENECARDS:PIK3CD REACTOME:61078 KEGG:5293 ATLASONC:PIK3CDID46261ch1p36 WIKI:PIK3CD phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 References_end</body> </html> </notes> <label text="p110*"/> <bbox w="80.0" h="40.0" x="19516.0" y="5653.0"/> <glyph class="state variable" id="_a4d86f8d-691e-4a1c-83d6-d11da29f5891"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19511.0" y="5668.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="shh1_shh3_s95_shh1_shh3_sa65"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Fes HUGO:FES HGNC:3657 ENTREZ:2242 UNIPROT:P07332 GENECARDS:FES REACTOME:54750 KEGG:2242 ATLASONC:GC_FES WIKI:FES Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17549397 PMID:19082481 PMID:11801735 PMID:12514186 References_end</body> </html> </notes> <label text="C-FES*"/> <bbox w="86.0" h="46.0" x="19515.047" y="5695.795"/> <glyph class="unit of information" id="_5126fb32-3f50-4722-8d01-92be43fe2342"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="19548.047" y="5690.795"/> </glyph> <glyph class="state variable" id="_9f70753a-0ef6-4121-b78a-4e1a7112de54"> <state value="P" variable="Y713"/> <bbox w="35.0" h="10.0" x="19498.076" y="5690.795"/> </glyph> <glyph class="state variable" id="_cce446ab-69b0-4d66-b37d-9dcfdffe1115"> <state value="P" variable="Y811"/> <bbox w="35.0" h="10.0" x="19583.547" y="5691.042"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh3_s99_shh1_shh3_csa13" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PI3,4,5-P3:TIAM1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re19(MAP:survival): PMID:12829230 PMID:11955434 PMID:15967165 PMID:15611338 References_end</body> </html> </notes> <label text="TIAM_PIP3"/> <bbox w="100.0" h="120.0" x="20046.0" y="4939.0"/> <glyph class="simple chemical" id="shh1_shh3_s100_shh1_shh3_sa69"> <label text="PI3,4,5-P3"/> <bbox w="70.0" h="25.0" x="20060.75" y="4957.75"/> </glyph> <glyph class="macromolecule" id="shh1_shh3_s101_shh1_shh3_sa70"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: T-cell lymphoma invasion and metastasis 1 HUGO:TIAM1 HGNC:11805 ENTREZ:7074 UNIPROT:Q13009 GENECARDS:TIAM1 REACTOME:195051 ATLASONC:TIAM1ID42557ch21q22 WIKI:TIAM1 Identifiers_end Maps_Modules_begin: MAP:emtcellmotility / MODULE:CYTOSKELETON_POLARITY MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:12829230 References_end</body> </html> </notes> <label text="TIAM1"/> <bbox w="80.0" h="40.0" x="20055.5" y="4984.25"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh3_s102_shh1_shh3_csa14" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GDP:RAC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re19(MAP:survival): PMID:12829230 PMID:11955434 PMID:15967165 PMID:15611338 References_end</body> </html> </notes> <label text="Rac1_GDP"/> <bbox w="100.0" h="120.0" x="19955.0" y="5188.0"/> <glyph class="macromolecule" id="shh1_shh3_s104_shh1_shh3_sa71"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <bbox w="80.0" h="40.0" x="19964.0" y="5201.0"/> <glyph class="state variable" id="_34cbb1e4-b6ac-4f01-a45f-614c3625227b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19959.0" y="5216.0"/> </glyph> </glyph> <glyph class="simple chemical" id="shh1_shh3_s111_shh1_shh3_sa78"> <label text="GDP"/> <bbox w="30.0" h="30.0" x="19989.0" y="5245.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh3_s114_shh1_shh3_csa16" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:PI3,4,5-P3:PREX* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re19(MAP:survival): PMID:12829230 PMID:11955434 PMID:15967165 PMID:15611338 References_end</body> </html> </notes> <label text="P-Rex_PIP"/> <bbox w="100.0" h="120.0" x="20180.0" y="4939.0"/> <glyph class="simple chemical" id="shh1_shh3_s115_shh1_shh3_sa83"> <label text="PI3,4,5-P3"/> <bbox w="70.0" h="25.0" x="20193.75" y="4952.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh3_s116_shh1_shh3_sa84"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 1 HUGO:PREX1 HGNC:32594 ENTREZ:57580 UNIPROT:Q8TCU6 GENECARDS:PREX1 KEGG:57580 ATLASONC:GC_PREX1 WIKI:PREX1 Phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 2 HUGO:PREX2 HGNC:22950 ENTREZ:80243 UNIPROT:Q70Z35 GENECARDS:PREX2 KEGG:80243 ATLASONC:GC_PREX2 WIKI:PREX2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11955434 PMID:21172654 References_end</body> </html> </notes> <label text="PREX*"/> <bbox w="80.0" h="40.0" x="20188.5" y="4980.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh3_s120_shh1_shh3_csa17" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:TSC1:TSC2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re24:(MAP:survival) PMID:15611338 References_end</body> </html> </notes> <label text="TSC1/2"/> <bbox w="100.0" h="120.0" x="19772.0" y="5388.0"/> <glyph class="macromolecule" id="shh1_shh3_s121_shh1_shh3_sa89"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: tuberous sclerosis 1 HUGO:TSC1 HGNC:12362 ENTREZ:7248 UNIPROT:Q92574 GENECARDS:TSC1 REACTOME:66499 KEGG:7248 ATLASONC:TSC1ID183 WIKI:TSC1 Q92574 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end Identifiers_begin: tuberous sclerosis 1 HUGO:TSC1 HGNC:12362 ENTREZ:7248 UNIPROT:Q92574 GENECARDS:TSC1 REACTOME:66499 KEGG:7248 ATLASONC:TSC1ID183 WIKI:TSC1 Q92574 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end</body> </html> </notes> <label text="TSC1"/> <bbox w="80.0" h="40.0" x="19780.5" y="5398.0"/> <glyph class="state variable" id="_1fd7871c-a7d3-4397-a40d-e80332a04e0f"> <state value="" variable="T417"/> <bbox w="30.0" h="10.0" x="19765.992" y="5393.0"/> </glyph> <glyph class="state variable" id="_a5547e6f-6e7a-40a9-8d30-d7d763b16b50"> <state value="" variable="S487"/> <bbox w="30.0" h="10.0" x="19845.5" y="5393.215"/> </glyph> <glyph class="state variable" id="_7aa9a05f-fbc9-45a2-929d-0333f7b5719e"> <state value="" variable="S584"/> <bbox w="30.0" h="10.0" x="19842.586" y="5433.0"/> </glyph> <glyph class="state variable" id="_3316b342-c184-4c8c-9157-9f3da6fefee9"> <state value="" variable="T1047"/> <bbox w="35.0" h="10.0" x="19763.0" y="5432.722"/> </glyph> <glyph class="state variable" id="_32054072-b5b4-4397-9de5-e16c06213feb"> <state value="" variable="S511"/> <bbox w="30.0" h="10.0" x="19845.5" y="5413.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh3_s122_shh1_shh3_sa90"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 GENECARDS:TSC2 REACTOME:404219 KEGG:7249 ATLASONC:TSC2ID184 WIKI:TSC2 P49815 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end Identifiers_begin: tuberous sclerosis 2 HUGO:TSC2 HGNC:12363 ENTREZ:7249 UNIPROT:P49815 GENECARDS:TSC2 REACTOME:404219 KEGG:7249 ATLASONC:TSC2ID184 WIKI:TSC2 P49815 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:APOPTOSIS_GENES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17680028 PMID:16636147 PMID:20146692 References_end</body> </html> </notes> <label text="TSC2"/> <bbox w="80.0" h="40.0" x="19780.5" y="5440.0"/> <glyph class="state variable" id="_fcf9fb97-1d09-481c-877a-c20a059a3184"> <state value="" variable="S1086"/> <bbox w="35.0" h="10.0" x="19843.0" y="5456.4663"/> </glyph> <glyph class="state variable" id="_d2b585e8-6d8d-42da-91fb-c71d656e342b"> <state value="" variable="S981"/> <bbox w="30.0" h="10.0" x="19842.082" y="5435.0"/> </glyph> <glyph class="state variable" id="_efeff0e5-0689-43d1-ad50-1d42ca17c54c"> <state value="" variable="S1130"/> <bbox w="35.0" h="10.0" x="19800.902" y="5475.0"/> </glyph> <glyph class="state variable" id="_79fa5617-5f26-4436-999d-bfd204b2d759"> <state value="" variable="T1462"/> <bbox w="35.0" h="10.0" x="19763.492" y="5435.0"/> </glyph> <glyph class="state variable" id="_673734b8-1f56-4637-8fc2-58fc3d0fe991"> <state value="" variable="S1132"/> <bbox w="35.0" h="10.0" x="19763.0" y="5473.9487"/> </glyph> <glyph class="state variable" id="_2184ebb5-feda-4369-8f75-a1c3c7b31c3c"> <state value="" variable="S939"/> <bbox w="30.0" h="10.0" x="19803.53" y="5435.0"/> </glyph> <glyph class="state variable" id="_97bb155a-5ae5-4593-83f1-4af6ccef1908"> <state value="" variable="S1088"/> <bbox w="35.0" h="10.0" x="19842.38" y="5475.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh3_s132_shh1_shh3_csa15" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GTP:RAC1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re19(MAP:survival): PMID:12829230 PMID:11955434 PMID:15967165 PMID:15611338 s_shh3_re23(MAP:survival): PMID:15901767 PMID:20595387 s_wnc1_re58(MAP:survival): PMID:16402909 PMID:12657629 References_end</body> </html> </notes> <label text="Rac1_GTP"/> <bbox w="100.0" h="120.0" x="20185.0" y="5188.0"/> <glyph class="macromolecule" id="shh1_shh3_s110_shh1_shh3_sa72"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> Identifiers_begin: Ras-related C3 botulin toxin substrate 1 (rho family, small GTP binding protein Rac1 HUGO:RAC1 HGNC:9801 ENTREZ:5879 UNIPROT:P63000 GENECARDS:RAC1 REACTOME:404635 KEGG:5879 ATLASONC:GC_RAC1 WIKI:RAC1 ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein RAC1) Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:TNF_RESPONSE MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18000759 PMID:19151919 Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <label text="RAC1"/> <bbox w="80.0" h="40.0" x="20193.5" y="5200.0"/> <glyph class="state variable" id="_9a23f3c7-5ae0-4024-937a-fda0e2541c76"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20188.5" y="5215.0"/> </glyph> </glyph> <glyph class="simple chemical" id="shh1_shh3_s109_shh1_shh3_sa77"> <label text="GTP"/> <bbox w="30.0" h="30.0" x="20218.75" y="5242.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh3_s134_shh1_shh3_csa10" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:G_beta_*:G_gamma_*:p101*:p110_beta__gamma_* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re10(MAP:survival): PMID:12297047 PMID:16847462 s_wnc1_re31:(MAP:survival) PMID:21736902 s_shh3_re21(MAP:survival): PMID:11955434 :Activation of P-Rex can be synergistically by PIP3 and Gi-proteins References_end</body> </html> </notes> <label text="(Giβgamma_dimer_PI3K)"/> <bbox w="184.0" h="123.0" x="18555.0" y="5555.0"/> <glyph class="macromolecule" id="shh1_shh3_s79_shh1_shh3_sa52"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Phosphoinositide-3-kinase, regulatory subunit 5, p101 HUGO:PIK3R5 HGNC:30035 ENTREZ:23533 UNIPROT:Q8WYR1 GENECARDS:PIK3R5 REACTOME:242723 KEGG:23533 ATLASONC:GC_PIK3R5 WIKI:PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:16847462 References_end Identifiers_begin: Phosphoinositide-3-kinase, regulatory subunit 5, p101 HUGO:PIK3R5 HGNC:30035 ENTREZ:23533 UNIPROT:Q8WYR1 GENECARDS:PIK3R5 REACTOME:242723 KEGG:23533 ATLASONC:GC_PIK3R5 WIKI:PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:16847462 References_end</body> </html> </notes> <label text="p101*"/> <bbox w="80.0" h="40.0" x="18566.5" y="5565.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh3_s80_shh1_shh3_sa53"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta "phosphoinositide-3-kinase, catalytic, beta polypeptide", PIK3C1 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma "phosphoinositide-3-kinase, catalytic, gamma polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:16847462 References_end Identifiers_begin: phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta "phosphoinositide-3-kinase, catalytic, beta polypeptide", PIK3C1 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma "phosphoinositide-3-kinase, catalytic, gamma polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:16847462 References_end</body> </html> </notes> <label text="p110βγ*"/> <bbox w="80.0" h="40.0" x="18566.5" y="5605.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh3_s81_shh1_shh3_sa54"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="80.0" h="40.0" x="18649.5" y="5565.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh3_s82_shh1_shh3_sa55"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="80.0" h="40.0" x="18649.5" y="5605.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh3_s135_shh1_shh3_csa11" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:p110*:p85* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re15(MAP:survival): PMID:11801735 PMID:19082481 s_akt1_re11(MAP:survival): PMID:15584861 PMID:10648629 References_end</body> </html> </notes> <label text="(Clas_IA_PI3K)"/> <bbox w="100.0" h="120.0" x="19625.0" y="5410.0"/> <glyph class="macromolecule" id="shh1_shh3_s93_shh1_shh3_sa63"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: phosphoinositide-3-kinase, regulatory subunit 1 (alpha) HUGO:PIK3R1 HGNC:8979 ENTREZ:5295 UNIPROT:P27986 GENECARDS:PIK3R1 REACTOME:61192 KEGG:5295 ATLASONC:PIK3R1ID41717ch5q13 WIKI:PIK3R1 phosphoinositide-3-kinase, regulatory subunit 2 (beta) HUGO:PIK3R2 HGNC:8980 ENTREZ:5296 UNIPROT:O00459 GENECARDS:PIK3R2 REACTOME:61194 KEGG:5296 ATLASONC:GC_PIK3R2 WIKI:PIK3R2 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) HUGO:PIK3R3 HGNC:8981 ENTREZ:8503 UNIPROT:Q92569 GENECARDS:PIK3R3 REACTOME:61182 KEGG:8503 ATLASONC:GC_PIK3R3 WIKI:PIK3R3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 PMID:19568798 PMID:12040186 References_end Identifiers_begin: phosphoinositide-3-kinase, regulatory subunit 1 (alpha) HUGO:PIK3R1 HGNC:8979 ENTREZ:5295 UNIPROT:P27986 GENECARDS:PIK3R1 REACTOME:61192 KEGG:5295 ATLASONC:PIK3R1ID41717ch5q13 WIKI:PIK3R1 phosphoinositide-3-kinase, regulatory subunit 2 (beta) HUGO:PIK3R2 HGNC:8980 ENTREZ:5296 UNIPROT:O00459 GENECARDS:PIK3R2 REACTOME:61194 KEGG:5296 ATLASONC:GC_PIK3R2 WIKI:PIK3R2 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) HUGO:PIK3R3 HGNC:8981 ENTREZ:8503 UNIPROT:Q92569 GENECARDS:PIK3R3 REACTOME:61182 KEGG:8503 ATLASONC:GC_PIK3R3 WIKI:PIK3R3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 PMID:19568798 PMID:12040186 References_end</body> </html> </notes> <label text="p85*"/> <bbox w="80.0" h="40.0" x="19634.5" y="5424.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh3_s92_shh1_shh3_sa64"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: phosphoinositide-3-kinase, catalytic, alpha polypeptide HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 GENECARDS:PIK3CA REACTOME:61074 KEGG:5290 ATLASONC:PIK3CAID415ch3q26 WIKI:PIK3CA phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, delta polypeptide HUGO:PIK3CD HGNC:8977 ENTREZ:5293 UNIPROT:O00329 GENECARDS:PIK3CD REACTOME:61078 KEGG:5293 ATLASONC:PIK3CDID46261ch1p36 WIKI:PIK3CD phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 References_end</body> </html> Identifiers_begin: phosphoinositide-3-kinase, catalytic, alpha polypeptide HUGO:PIK3CA HGNC:8975 ENTREZ:5290 UNIPROT:P42336 GENECARDS:PIK3CA REACTOME:61074 KEGG:5290 ATLASONC:PIK3CAID415ch3q26 WIKI:PIK3CA phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, delta polypeptide HUGO:PIK3CD HGNC:8977 ENTREZ:5293 UNIPROT:O00329 GENECARDS:PIK3CD REACTOME:61078 KEGG:5293 ATLASONC:PIK3CDID46261ch1p36 WIKI:PIK3CD phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha "phosphoinositide-3-kinase catalytic alpha polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16847462 References_end</body> </html> </notes> <label text="p110*"/> <bbox w="80.0" h="40.0" x="19634.5" y="5466.0"/> <glyph class="state variable" id="_ef04d1dc-3761-4118-9af1-6363d3b31ef1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19629.5" y="5481.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh3_s136_shh1_shh3_csa9" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:p101*:p110_beta__gamma_* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re10(MAP:survival): PMID:12297047 PMID:16847462 s_wnc1_re31:(MAP:survival) PMID:21736902 References_end</body> </html> </notes> <label text="(Class_IB_PI3K)"/> <bbox w="100.0" h="120.0" x="18297.0" y="5555.0"/> <glyph class="macromolecule" id="shh1_shh3_s75_shh1_shh3_sa49"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: Phosphoinositide-3-kinase, regulatory subunit 5, p101 HUGO:PIK3R5 HGNC:30035 ENTREZ:23533 UNIPROT:Q8WYR1 GENECARDS:PIK3R5 REACTOME:242723 KEGG:23533 ATLASONC:GC_PIK3R5 WIKI:PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:16847462 References_end Identifiers_begin: Phosphoinositide-3-kinase, regulatory subunit 5, p101 HUGO:PIK3R5 HGNC:30035 ENTREZ:23533 UNIPROT:Q8WYR1 GENECARDS:PIK3R5 REACTOME:242723 KEGG:23533 ATLASONC:GC_PIK3R5 WIKI:PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:16847462 References_end</body> </html> </notes> <label text="p101*"/> <bbox w="80.0" h="40.0" x="18304.5" y="5566.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh3_s76_shh1_shh3_sa50"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body>Identifiers_begin: phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta "phosphoinositide-3-kinase, catalytic, beta polypeptide", PIK3C1 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma "phosphoinositide-3-kinase, catalytic, gamma polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:16847462 References_end Identifiers_begin: phosphoinositide-3-kinase, catalytic, beta polypeptide HUGO:PIK3CB HGNC:8976 ENTREZ:5291 UNIPROT:P42338 GENECARDS:PIK3CB REACTOME:61076 KEGG:5291 ATLASONC:GC_PIK3CB WIKI:PIK3CB phosphoinositide-3-kinase, catalytic, gamma polypeptide HUGO:PIK3CG HGNC:8978 ENTREZ:5294 UNIPROT:P48736 GENECARDS:PIK3CG REACTOME:61080 KEGG:5294 ATLASONC:GC_PIK3CG WIKI:PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta "phosphoinositide-3-kinase, catalytic, beta polypeptide", PIK3C1 phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma "phosphoinositide-3-kinase, catalytic, gamma polypeptide" Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:16847462 References_end</body> </html> </notes> <label text="p110βγ*"/> <bbox w="80.0" h="40.0" x="18304.5" y="5609.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh3_s137_shh1_shh3_csa18" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:Caspase9*:DRAL*:PTCH*:TUCAN* Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re26:(MAP:survival) PMID:19465923 References_end</body> </html> </notes> <label text="(Caspase_activating_complex)"/> <bbox w="192.0" h="160.0" x="19694.0" y="4902.0"/> <glyph class="macromolecule" id="shh1_shh3_s129_shh1_shh3_sa92"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Four and half LIM domains 2, Dral HUGO:FHL2 HGNC:3703 ENTREZ:2274 UNIPROT:Q14192 GENECARDS:FHL2 REACTOME:64554 KEGG:2274 ATLASONC:FHL2ID44092ch2q12 WIKI:FHL2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19465923 References_end</body> </html> </notes> <label text="DRAL*"/> <bbox w="80.0" h="40.0" x="19793.0" y="4915.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh3_s130_shh1_shh3_sa93"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Caspase recruitment domain family 8 HUGO:CARD8 HGNC:17057 ENTREZ:22900 UNIPROT:Q9Y2G2 GENECARDS:CARD8 KEGG:22900 ATLASONC:CARD8ID913ch19q13 WIKI:CARD8 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19465923 References_end</body> </html> </notes> <label text="TUCAN*"/> <bbox w="80.0" h="40.0" x="19793.0" y="4956.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh3_s128_shh1_shh3_sa95"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Patched 1 HUGO:PTCH1 HGNC:9585 ENTREZ:5727 UNIPROT:Q13635 GENECARDS:PTCH1 REACTOME:62393 KEGG:5727 ATLASONC:PTCH100 WIKI:PTCH1 Patched 2 HUGO:PTCH2 HGNC:9586 ENTREZ:8643 UNIPROT:Q9Y6C5 GENECARDS:PTCH2 REACTOME:62395 KEGG:8643 ATLASONC:PTCH2ID41892ch1p34 WIKI:PTCH2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:10021362 PMID:17641202 References_end</body> </html> </notes> <label text="PTCH*"/> <bbox w="78.0" h="114.0" x="19706.5" y="4923.0"/> <glyph class="unit of information" id="_e695099a-8a16-4dc2-8ab3-7a7f1685e808"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="19723.0" y="4918.0"/> </glyph> </glyph> <glyph class="macromolecule multimer" id="shh1_shh3_s133_shh1_shh3_sa99"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: caspase 9 apoptosis-related cysteine peptidase "caspase 9 apoptosis-related cysteine protease" HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end References_begin: Caspase9 is phosphorylated on Thr125 in a MEK1/2-dependent manner in vivo. Furthermore caspase9 is efficiently phosphorylated on Thr125 by ERK in vitro suggesting that it is targeted directly by ERK in vivo. This is one of the ways ERK plays its anti-apoptotic role. PMID:12792650 References_end Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 GENECARDS:CASP9 REACTOME:57034 KEGG:842 ATLASONC:CASP9ID423ch1p36 WIKI:CASP9 "caspase 9 apoptosis-related cysteine protease" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19788417 PMID:16977332 Caspase9 is phosphorylated on Thr125 in a MEK1/2-dependent manner in vivo. Furthermore caspase9 is efficiently phosphorylated on Thr125 by ERK in vitro suggesting that it is targeted directly by ERK in vivo. This is one of the ways ERK plays its anti-apoptotic role. PMID:12792650 References_end</body> </html> Identifiers_begin: caspase 9, apoptosis-related cysteine peptidase HUGO:CASP9 HGNC:1511 ENTREZ:842 UNIPROT:P55211 GENECARDS:CASP9 REACTOME:57034 KEGG:842 ATLASONC:CASP9ID423ch1p36 WIKI:CASP9 "caspase 9 apoptosis-related cysteine protease" Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:CASPASES MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19788417 PMID:16977332 Caspase9 is phosphorylated on Thr125 in a MEK1/2-dependent manner in vivo. Furthermore caspase9 is efficiently phosphorylated on Thr125 by ERK in vitro suggesting that it is targeted directly by ERK in vivo. This is one of the ways ERK plays its anti-apoptotic role. PMID:12792650 References_end</body> </html> </notes> <label text="Caspase9*"/> <bbox w="86.0" h="46.0" x="19787.5" y="4996.0"/> <glyph class="unit of information" id="_dc5019c5-8ef0-4111-8415-a6312df29c49"> <label text="N:2"/> <bbox w="20.0" h="10.0" x="19820.5" y="4991.0"/> </glyph> <glyph class="state variable" id="_df8b5fe6-67d7-412b-b274-00f08d8ca88a"> <state value="" variable="S196"/> <bbox w="30.0" h="10.0" x="19858.5" y="4992.1396"/> </glyph> <glyph class="state variable" id="_47db32d8-74cd-42f8-9236-95343fafad1d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19782.5" y="5014.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh3_s138_shh1_shh3_csa4" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GDP:G_alpha__sub_i_endsub_*:G_beta_*:G_gamma_*:SMO Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re2(MAP:survival): PMID:16885213 PMID:18815277 References_end</body> </html> </notes> <label text="(Smo_Gi_protein)"/> <bbox w="258.0" h="135.0" x="19017.0" y="4913.0"/> <glyph class="macromolecule" id="shh1_shh3_s1_shh1_shh3_sa1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Smoothened HUGO:SMO HGNC:11119 ENTREZ:6608 UNIPROT:Q99835 GENECARDS:SMO REACTOME:64670 KEGG:6608 ATLASONC:GC_SMO WIKI:SMO Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18820483 PMID:17641202 Smoothened homologue (Drosophila) References_end</body> </html> </notes> <label text="SMO"/> <bbox w="80.0" h="40.0" x="19103.0" y="4920.0"/> <glyph class="state variable" id="_e060a2d5-c515-48f1-9eb2-37dd951c129a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19178.0" y="4915.0"/> </glyph> <glyph class="state variable" id="_35c9846c-ede9-450e-b2e6-e2e366331797"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19178.0" y="4915.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh3_s33_shh1_shh3_sa20"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 Guanine nucleotide binding protein (G-protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 Guanine nucleotide binding protein (G-protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17430994 Guanine nucleotide binding protein (G-protein) References_end</body> </html> </notes> <label text="Gαi*"/> <bbox w="80.0" h="40.0" x="19021.0" y="4964.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh3_s34_shh1_shh3_sa21"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="80.0" h="40.0" x="19103.0" y="4964.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh3_s35_shh1_shh3_sa22"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="80.0" h="40.0" x="19186.0" y="4964.0"/> </glyph> <glyph class="simple chemical" id="shh1_shh3_s106_shh1_shh3_sa73"> <label text="GDP"/> <bbox w="30.0" h="30.0" x="19047.5" y="5004.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s637_shh1_shh1_sa53" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re92:(MAP:survival) PMID:18997815 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> </notes> <label text="E1*"/> <clone/> <bbox w="80.0" h="40.0" x="18671.0" y="1149.0"/> </glyph> <glyph class="macromolecule" id="shh1_s637_shh1_shh1_sa277" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re92:(MAP:survival) PMID:18997815 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> </notes> <label text="E1*"/> <clone/> <bbox w="80.0" h="40.0" x="19074.0" y="2253.0"/> </glyph> <glyph class="macromolecule" id="shh1_s637_shh1_shh1_sa280" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re92:(MAP:survival) PMID:18997815 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end Identifiers_begin: ubiquitin-like modifier activating enzyme 1 HUGO:UBA1 HGNC:12469 ENTREZ:7317 UNIPROT:P22314 GENECARDS:UBA1 REACTOME:66719 KEGG:7317 ATLASONC:GC_UBA1 WIKI:UBA1 ubiquitin-like modifier activating enzyme 2 HUGO:UBA2 HGNC:30661 ENTREZ:10054 UNIPROT:Q9UBT2 GENECARDS:UBA2 KEGG:10054 ATLASONC:GC_UBA2 WIKI:UBA2 ubiquitin-like modifier activating enzyme 5 HUGO:UBA5 HGNC:23230 ENTREZ:79876 UNIPROT:Q9GZZ9 GENECARDS:UBA5 REACTOME:253490 KEGG:79876 ATLASONC:GC_UBA5 WIKI:UBA5 ubiquitin-like modifier activating enzyme 6 HUGO:UBA6 HGNC:25581 ENTREZ:55236 UNIPROT:A0AVT1 GENECARDS:UBA6 REACTOME:253493 KEGG:55236 WIKI:UBA6 ubiquitin-like modifier activating enzyme 7 HUGO:UBA7 HGNC:12471 ENTREZ:7318 UNIPROT:P41226 GENECARDS:UBA7 REACTOME:66721 KEGG:7318 ATLASONC:GC_UBA7 WIKI:UBA7 ubiquitin-like modifier activating enzyme 3 HUGO:UBA3 HGNC:12470 ENTREZ:9039 UNIPROT:Q8TBC4 GENECARDS:UBA3 REACTOME:155454 KEGG:9039 ATLASONC:GC_UBA3 WIKI:UBA3 ENREZ:79876 POC20 "POC20 centriolar protein homolog (Chlamydomonas)" "UBA1 ubiquitin-activating enzyme E1 homolog (yeast)" UBE1X Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 PMID:19352404 SAE1/SAE2 References_end</body> </html> </notes> <label text="E1*"/> <clone/> <bbox w="80.0" h="40.0" x="18065.0" y="1155.0"/> </glyph> <glyph class="macromolecule" id="shh1_s638_shh1_shh1_sa147" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 3 HUGO:GLI3 HGNC:4319 ENTREZ:2737 UNIPROT:P10071 GENECARDS:GLI3 KEGG:2737 ATLASONC:GC_GLI3 WIKI:GLI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI3-190*"/> <clone/> <bbox w="165.0" h="41.0" x="18005.0" y="767.0"/> <glyph class="state variable" id="_6ce71e07-04a2-42fd-a569-74e6c96882a1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18032.01" y="762.0"/> </glyph> <glyph class="state variable" id="_e9dd4952-9191-4182-9248-9c7848e057b8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18051.521" y="762.0"/> </glyph> <glyph class="state variable" id="_af575539-1605-4246-8e18-a2d212fded8c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18064.984" y="762.0"/> </glyph> <glyph class="state variable" id="_8b65a5c4-5d8a-435e-b1ed-62f675d48ce9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18103.355" y="803.0"/> </glyph> <glyph class="state variable" id="_27c5eb36-c215-4e1e-9c5a-45fd5938f062"> <state value="" variable="S860"/> <bbox w="30.0" h="10.0" x="18090.152" y="762.0"/> </glyph> <glyph class="state variable" id="_fc201827-7746-48ab-b3e6-ee76f71dbef6"> <state value="" variable="S907"/> <bbox w="30.0" h="10.0" x="18037.387" y="803.0"/> </glyph> <glyph class="state variable" id="_f4e2b9eb-1259-439e-9678-400b2f045f93"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18032.01" y="762.0"/> </glyph> <glyph class="state variable" id="_8157179e-aa98-4993-80b4-c3ad717adc99"> <state value="" variable="S873"/> <bbox w="30.0" h="10.0" x="18155.0" y="782.5653"/> </glyph> <glyph class="state variable" id="_17cd0d7b-033f-448a-954e-6d39c70ac051"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18051.521" y="762.0"/> </glyph> <glyph class="state variable" id="_8f3ca03e-7d38-47e4-b0eb-c295f7d1de06"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="17991.016" y="762.0"/> </glyph> <glyph class="state variable" id="_80c8f8a4-f143-4d3c-ab87-b5171cbc5234"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18064.984" y="762.0"/> </glyph> <glyph class="state variable" id="_4589e7f1-9603-4cae-a2be-6563526b6cad"> <state value="" variable="S868"/> <bbox w="30.0" h="10.0" x="18147.951" y="762.0"/> </glyph> <glyph class="state variable" id="_08c0a9f0-cff9-4252-a560-7dc6c2cd39f2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18103.355" y="803.0"/> </glyph> <glyph class="state variable" id="_e05f0b77-d91d-40f8-bdaa-c28f08107380"> <state value="" variable="S877"/> <bbox w="30.0" h="10.0" x="18153.725" y="803.0"/> </glyph> <glyph class="state variable" id="_f6590e15-b076-4f81-a198-234c88a54036"> <state value="" variable="S880"/> <bbox w="30.0" h="10.0" x="18111.1" y="803.0"/> </glyph> <glyph class="state variable" id="_5617aa0d-3b80-467d-b7ea-36d51f20cf07"> <state value="" variable="S903"/> <bbox w="30.0" h="10.0" x="18073.953" y="803.0"/> </glyph> <glyph class="state variable" id="_80eb1dba-f1a6-4f83-adaa-94e48935233b"> <state value="" variable="S910"/> <bbox w="30.0" h="10.0" x="17990.494" y="803.0"/> </glyph> <glyph class="state variable" id="_8d0cabdf-f3b1-4253-99c2-b979a0d003da"> <state value="" variable="S852"/> <bbox w="30.0" h="10.0" x="18070.916" y="762.0"/> </glyph> <glyph class="state variable" id="_ca46fd0f-9d32-44dd-9586-4226794db5f2"> <state value="" variable="S1006"/> <bbox w="35.0" h="10.0" x="17987.5" y="777.0116"/> </glyph> <glyph class="state variable" id="_03318767-8dec-4645-8f07-ddc5f63656f6"> <state value="" variable="S865"/> <bbox w="30.0" h="10.0" x="18107.457" y="762.0"/> </glyph> <glyph class="state variable" id="_e0bd9df0-555c-4692-869c-3138b73520d7"> <state value="" variable="S980"/> <bbox w="30.0" h="10.0" x="17990.0" y="784.7311"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s638_shh1_shh1_sa199" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 3 HUGO:GLI3 HGNC:4319 ENTREZ:2737 UNIPROT:P10071 GENECARDS:GLI3 KEGG:2737 ATLASONC:GC_GLI3 WIKI:GLI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI3-190*"/> <clone/> <bbox w="165.0" h="41.0" x="19942.75" y="1230.0"/> <glyph class="state variable" id="_f660495b-79e7-4e7d-8a08-5cda675a2d0b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19969.76" y="1225.0"/> </glyph> <glyph class="state variable" id="_d10efa53-6dc2-48cf-b6bd-9b894d0d7eab"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19989.271" y="1225.0"/> </glyph> <glyph class="state variable" id="_a6f51836-f464-4215-a4bc-f1622ce66d0a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20002.734" y="1225.0"/> </glyph> <glyph class="state variable" id="_b1e8ca48-1f79-4ad9-bca1-a1056b31d55c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20041.105" y="1266.0"/> </glyph> <glyph class="state variable" id="_dc661bdc-34de-4a1c-b5a9-16539752b70a"> <state value="" variable="S860"/> <bbox w="30.0" h="10.0" x="20027.902" y="1225.0"/> </glyph> <glyph class="state variable" id="_1f4ccf09-209e-4cfb-9351-fd407cf5d748"> <state value="" variable="S907"/> <bbox w="30.0" h="10.0" x="19975.137" y="1266.0"/> </glyph> <glyph class="state variable" id="_b66945b2-8fd1-4594-bdc4-f07ebd7d9886"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19969.76" y="1225.0"/> </glyph> <glyph class="state variable" id="_33d7ef12-03c5-4f57-9140-99bb2f20f42e"> <state value="" variable="S873"/> <bbox w="30.0" h="10.0" x="20092.75" y="1245.5653"/> </glyph> <glyph class="state variable" id="_a595f988-0429-48c2-bf8f-2f2eaafd5332"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19989.271" y="1225.0"/> </glyph> <glyph class="state variable" id="_e86ce14e-00d6-4036-a9de-1705817d7d51"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="19928.766" y="1225.0"/> </glyph> <glyph class="state variable" id="_79024608-8e2e-461b-b084-904c89fad815"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20002.734" y="1225.0"/> </glyph> <glyph class="state variable" id="_3253cee4-4f46-46f8-b620-8cffa8bfcb53"> <state value="" variable="S868"/> <bbox w="30.0" h="10.0" x="20085.701" y="1225.0"/> </glyph> <glyph class="state variable" id="_c090fed2-988a-4f7e-93e0-0a3205eb13bf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="20041.105" y="1266.0"/> </glyph> <glyph class="state variable" id="_ec5417a4-e002-4b8a-a84e-7736463ee5cf"> <state value="" variable="S877"/> <bbox w="30.0" h="10.0" x="20091.475" y="1266.0"/> </glyph> <glyph class="state variable" id="_40328dfe-87a7-4845-8ef9-c804552d64dc"> <state value="" variable="S880"/> <bbox w="30.0" h="10.0" x="20048.85" y="1266.0"/> </glyph> <glyph class="state variable" id="_b517cb18-686f-4acd-8707-b377d2eadbc8"> <state value="" variable="S903"/> <bbox w="30.0" h="10.0" x="20011.703" y="1266.0"/> </glyph> <glyph class="state variable" id="_aecf9d3a-770e-4e40-9bb0-d1a50366bb8b"> <state value="" variable="S910"/> <bbox w="30.0" h="10.0" x="19928.244" y="1266.0"/> </glyph> <glyph class="state variable" id="_56e60dad-95d3-408b-b757-257854271394"> <state value="" variable="S852"/> <bbox w="30.0" h="10.0" x="20008.666" y="1225.0"/> </glyph> <glyph class="state variable" id="_e18a2ab1-4fac-4599-8bff-833b1011c94f"> <state value="" variable="S1006"/> <bbox w="35.0" h="10.0" x="19925.25" y="1240.0116"/> </glyph> <glyph class="state variable" id="_a01d1bc5-e0a6-4530-be26-dc8356044a23"> <state value="" variable="S865"/> <bbox w="30.0" h="10.0" x="20045.207" y="1225.0"/> </glyph> <glyph class="state variable" id="_40015297-aa64-4fed-875c-2a2ec9ca65ae"> <state value="" variable="S980"/> <bbox w="30.0" h="10.0" x="19927.75" y="1247.7311"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s639_shh1_shh1_sa180" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Unc-51-like kinase 3 HUGO:ULK3 HGNC:19703 ENTREZ:25989 UNIPROT:Q6PHR2 GENECARDS:ULK3 ATLASONC:GC_ULK3 WIKI:ULK3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Unc-51-like kinase PMID:20643644 PMID:19878745 References_end</body> </html> </notes> <label text="ULK3"/> <clone/> <bbox w="80.0" h="40.0" x="18108.0" y="322.0"/> <glyph class="state variable" id="_6692d9d6-dfeb-4175-8ec6-2df13fd82d72"> <state value="" variable="S384"/> <bbox w="30.0" h="10.0" x="18172.38" y="357.0"/> </glyph> <glyph class="state variable" id="_b1bd5678-e388-4210-8879-0368dcbb3d3e"> <state value="" variable="S464"/> <bbox w="30.0" h="10.0" x="18093.0" y="356.7223"/> </glyph> <glyph class="state variable" id="_b8153551-1cc7-432a-abfe-e622415c3ae2"> <state value="" variable="S300"/> <bbox w="30.0" h="10.0" x="18093.492" y="317.0"/> </glyph> <glyph class="state variable" id="_4a50fb6a-0d3c-44eb-b655-289eeb669cc2"> <state value="" variable="S350"/> <bbox w="30.0" h="10.0" x="18173.0" y="317.21478"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s639_shh1_shh1_sa200" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Unc-51-like kinase 3 HUGO:ULK3 HGNC:19703 ENTREZ:25989 UNIPROT:Q6PHR2 GENECARDS:ULK3 ATLASONC:GC_ULK3 WIKI:ULK3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Unc-51-like kinase PMID:20643644 PMID:19878745 References_end</body> </html> </notes> <label text="ULK3"/> <clone/> <bbox w="80.0" h="40.0" x="19985.75" y="1323.0"/> <glyph class="state variable" id="_16153fce-2436-4370-8e71-9a859da18aea"> <state value="" variable="S384"/> <bbox w="30.0" h="10.0" x="20050.13" y="1358.0"/> </glyph> <glyph class="state variable" id="_9263c843-8145-4741-afae-ee310666c909"> <state value="" variable="S464"/> <bbox w="30.0" h="10.0" x="19970.75" y="1357.7223"/> </glyph> <glyph class="state variable" id="_9bc9b7fa-45e7-40f3-b102-a783a501a566"> <state value="" variable="S300"/> <bbox w="30.0" h="10.0" x="19971.242" y="1318.0"/> </glyph> <glyph class="state variable" id="_7bfcf0a4-034d-4bf7-be71-92ab1fd8d95e"> <state value="" variable="S350"/> <bbox w="30.0" h="10.0" x="20050.75" y="1318.2147"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s639_shh1_shh1_sa211" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Unc-51-like kinase 3 HUGO:ULK3 HGNC:19703 ENTREZ:25989 UNIPROT:Q6PHR2 GENECARDS:ULK3 ATLASONC:GC_ULK3 WIKI:ULK3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Unc-51-like kinase PMID:20643644 PMID:19878745 References_end</body> </html> </notes> <label text="ULK3"/> <clone/> <bbox w="80.0" h="40.0" x="18895.5" y="1618.7703"/> <glyph class="state variable" id="_7fc8d015-94b4-49b1-831d-ee21ae70c314"> <state value="" variable="S384"/> <bbox w="30.0" h="10.0" x="18959.88" y="1653.7703"/> </glyph> <glyph class="state variable" id="_67427b28-ce89-4538-9973-75287242a09c"> <state value="" variable="S464"/> <bbox w="30.0" h="10.0" x="18880.5" y="1653.4926"/> </glyph> <glyph class="state variable" id="_7a5e2a8e-bbcc-4e51-9a2e-9e7a36109396"> <state value="" variable="S300"/> <bbox w="30.0" h="10.0" x="18880.992" y="1613.7703"/> </glyph> <glyph class="state variable" id="_744af1c4-f879-44b1-9558-ba172d916b9a"> <state value="" variable="S350"/> <bbox w="30.0" h="10.0" x="18960.5" y="1613.985"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s639_shh1_shh1_sa227" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Unc-51-like kinase 3 HUGO:ULK3 HGNC:19703 ENTREZ:25989 UNIPROT:Q6PHR2 GENECARDS:ULK3 ATLASONC:GC_ULK3 WIKI:ULK3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Unc-51-like kinase PMID:20643644 PMID:19878745 References_end</body> </html> </notes> <label text="ULK3"/> <clone/> <bbox w="80.0" h="40.0" x="18128.75" y="1302.0"/> <glyph class="state variable" id="_a1ee5e71-64af-418e-8392-088178e8b1fe"> <state value="" variable="S384"/> <bbox w="30.0" h="10.0" x="18193.13" y="1337.0"/> </glyph> <glyph class="state variable" id="_0dbf2d46-6627-4221-aa5b-c834f61cf79e"> <state value="" variable="S464"/> <bbox w="30.0" h="10.0" x="18113.75" y="1336.7223"/> </glyph> <glyph class="state variable" id="_c410362c-9d65-42d0-bbfa-3d24efb63100"> <state value="" variable="S300"/> <bbox w="30.0" h="10.0" x="18114.242" y="1297.0"/> </glyph> <glyph class="state variable" id="_8cd9c084-fe38-4eaf-b290-2bd103b25746"> <state value="" variable="S350"/> <bbox w="30.0" h="10.0" x="18193.75" y="1297.2147"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s639_shh1_shh1_sa245" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Unc-51-like kinase 3 HUGO:ULK3 HGNC:19703 ENTREZ:25989 UNIPROT:Q6PHR2 GENECARDS:ULK3 ATLASONC:GC_ULK3 WIKI:ULK3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Unc-51-like kinase PMID:20643644 PMID:19878745 References_end</body> </html> </notes> <label text="ULK3"/> <clone/> <bbox w="80.0" h="40.0" x="18431.75" y="2114.0"/> <glyph class="state variable" id="_43bb2093-efa2-4ff2-a5f3-cc0885c6b5a4"> <state value="" variable="S384"/> <bbox w="30.0" h="10.0" x="18496.13" y="2149.0"/> </glyph> <glyph class="state variable" id="_c08a54a4-5691-470a-bf2a-8302bc2b4054"> <state value="" variable="S464"/> <bbox w="30.0" h="10.0" x="18416.75" y="2148.7224"/> </glyph> <glyph class="state variable" id="_abd58afb-86da-493d-b054-68e6c9c01829"> <state value="" variable="S300"/> <bbox w="30.0" h="10.0" x="18417.242" y="2109.0"/> </glyph> <glyph class="state variable" id="_591e554e-7c84-48a7-804e-4695446ea8bb"> <state value="" variable="S350"/> <bbox w="30.0" h="10.0" x="18496.75" y="2109.2148"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s640_shh1_shh1_sa278" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re92:(MAP:survival) PMID:18997815 s_akt2_re91:(MAP:survival) PMID:15668399 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C ubiquitin-conjugating enzyme E2D 1 HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 ubiquitin-conjugating enzyme E2E 1 HUGO:UBE2E1 HGNC:12477 ENTREZ:7324 UNIPROT:P51965 GENECARDS:UBE2E1 REACTOME:66739 KEGG:7324 ATLASONC:GC_UBE2E1 WIKI:UBE2E1 ubiquitin-conjugating enzyme E2E 2 HUGO:UBE2E2 HGNC:12478 ENTREZ:7325 UNIPROT:Q96LR5 GENECARDS:UBE2E2 REACTOME:155471 KEGG:7325 ATLASONC:GC_UBE2E2 WIKI:UBE2E2 ubiquitin-conjugating enzyme E2G 1 HUGO:UBE2G1 HGNC:12482 ENTREZ:7326 UNIPROT:P62253 GENECARDS:UBE2G1 REACTOME:66753 KEGG:7326 ATLASONC:GC_UBE2G1 WIKI:UBE2G1 ubiquitin-conjugating enzyme E2G 2 HUGO:UBE2G2 HGNC:12483 ENTREZ:7327 UNIPROT:P60604 GENECARDS:UBE2G2 REACTOME:66773 KEGG:7327 ATLASONC:GC_UBE2G2 WIKI:UBE2G2 ubiquitin-conjugating enzyme E2H HUGO:UBE2H HGNC:12484 ENTREZ:7328 UNIPROT:P62256 GENECARDS:UBE2H REACTOME:66759 KEGG:7328 ATLASONC:GC_UBE2H WIKI:UBE2H ubiquitin-conjugating enzyme E2I HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I ubiquitin-conjugating enzyme E2 J1 HUGO:UBE2J1 HGNC:17598 ENTREZ:51465 UNIPROT:Q9Y385 GENECARDS:UBE2J1 REACTOME:155484 KEGG:51465 ATLASONC:GC_UBE2J1 WIKI:UBE2J1 ubiquitin-conjugating enzyme E2 J2 HUGO:UBE2J2 HGNC:19268 ENTREZ:118424 UNIPROT:Q8N2K1 GENECARDS:UBE2J2 REACTOME:155486 KEGG:118424 WIKI:UBE2J2 ubiquitin-conjugating enzyme E2K HUGO:UBE2K HGNC:4914 ENTREZ:3093 UNIPROT:P61086 GENECARDS:UBE2K REACTOME:66723 KEGG:3093 WIKI:UBE2K ubiquitin-conjugating enzyme E2L 3 HUGO:UBE2L3 HGNC:12488 ENTREZ:7332 UNIPROT:P68036 GENECARDS:UBE2L3 REACTOME:66741 KEGG:7332 ATLASONC:GC_UBE2L3 WIKI:UBE2L3 ubiquitin-conjugating enzyme E2L 4 HUGO:UBE2L4 HGNC:12489 ENTREZ:7333 GENECARDS:UBE2L4 WIKI:UBE2L4 ubiquitin-conjugating enzyme E2L 6 HUGO:UBE2L6 HGNC:12490 ENTREZ:9246 UNIPROT:O14933 GENECARDS:UBE2L6 REACTOME:66745 KEGG:9246 ATLASONC:GC_UBE2L6 WIKI:UBE2L6 ubiquitin-conjugating enzyme E2M HUGO:UBE2M HGNC:12491 ENTREZ:9040 UNIPROT:P61081 GENECARDS:UBE2M REACTOME:66777 KEGG:9040 ATLASONC:GC_UBE2M WIKI:UBE2M ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 GENECARDS:UBE2N REACTOME:66781 KEGG:7334 ATLASONC:GC_UBE2N WIKI:UBE2N ubiquitin-conjugating enzyme E2O HUGO:UBE2O HGNC:29554 ENTREZ:63893 UNIPROT:Q9C0C9 GENECARDS:UBE2O REACTOME:253534 KEGG:63893 ATLASONC:GC_UBE2O WIKI:UBE2O ubiquitin-conjugating enzyme E2Q family member 1 HUGO:UBE2Q1 HGNC:15698 ENTREZ:55585 UNIPROT:Q7Z7E8 GENECARDS:UBE2Q1 REACTOME:253474 KEGG:55585 ATLASONC:GC_UBE2Q1 WIKI:UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 2 HUGO:UBE2Q2 HGNC:19248 ENTREZ:92912 UNIPROT:Q8WVN8 GENECARDS:UBE2Q2 REACTOME:253479 ATLASONC:GC_UBE2Q2 WIKI:UBE2Q2 ubiquitin-conjugating enzyme E2R 2 HUGO:UBE2R2 HGNC:19907 ENTREZ:54926 UNIPROT:Q712K3 GENECARDS:UBE2R2 REACTOME:253483 KEGG:54926 ATLASONC:GC_UBE2R2 WIKI:UBE2R2 ubiquitin-conjugating enzyme E2S HUGO:UBE2S HGNC:17895 ENTREZ:27338 UNIPROT:Q16763 GENECARDS:UBE2S REACTOME:66751 KEGG:27338 ATLASONC:GC_UBE2S WIKI:UBE2S ubiquitin-conjugating enzyme E2Z HUGO:UBE2Z HGNC:25847 ENTREZ:65264 UNIPROT:Q9H832 GENECARDS:UBE2Z REACTOME:253545 KEGG:65264 WIKI:UBE2Z Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C ubiquitin-conjugating enzyme E2D 1 HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 ubiquitin-conjugating enzyme E2E 1 HUGO:UBE2E1 HGNC:12477 ENTREZ:7324 UNIPROT:P51965 GENECARDS:UBE2E1 REACTOME:66739 KEGG:7324 ATLASONC:GC_UBE2E1 WIKI:UBE2E1 ubiquitin-conjugating enzyme E2E 2 HUGO:UBE2E2 HGNC:12478 ENTREZ:7325 UNIPROT:Q96LR5 GENECARDS:UBE2E2 REACTOME:155471 KEGG:7325 ATLASONC:GC_UBE2E2 WIKI:UBE2E2 ubiquitin-conjugating enzyme E2G 1 HUGO:UBE2G1 HGNC:12482 ENTREZ:7326 UNIPROT:P62253 GENECARDS:UBE2G1 REACTOME:66753 KEGG:7326 ATLASONC:GC_UBE2G1 WIKI:UBE2G1 ubiquitin-conjugating enzyme E2G 2 HUGO:UBE2G2 HGNC:12483 ENTREZ:7327 UNIPROT:P60604 GENECARDS:UBE2G2 REACTOME:66773 KEGG:7327 ATLASONC:GC_UBE2G2 WIKI:UBE2G2 ubiquitin-conjugating enzyme E2H HUGO:UBE2H HGNC:12484 ENTREZ:7328 UNIPROT:P62256 GENECARDS:UBE2H REACTOME:66759 KEGG:7328 ATLASONC:GC_UBE2H WIKI:UBE2H ubiquitin-conjugating enzyme E2I HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I ubiquitin-conjugating enzyme E2 J1 HUGO:UBE2J1 HGNC:17598 ENTREZ:51465 UNIPROT:Q9Y385 GENECARDS:UBE2J1 REACTOME:155484 KEGG:51465 ATLASONC:GC_UBE2J1 WIKI:UBE2J1 ubiquitin-conjugating enzyme E2 J2 HUGO:UBE2J2 HGNC:19268 ENTREZ:118424 UNIPROT:Q8N2K1 GENECARDS:UBE2J2 REACTOME:155486 KEGG:118424 WIKI:UBE2J2 ubiquitin-conjugating enzyme E2K HUGO:UBE2K HGNC:4914 ENTREZ:3093 UNIPROT:P61086 GENECARDS:UBE2K REACTOME:66723 KEGG:3093 WIKI:UBE2K ubiquitin-conjugating enzyme E2L 3 HUGO:UBE2L3 HGNC:12488 ENTREZ:7332 UNIPROT:P68036 GENECARDS:UBE2L3 REACTOME:66741 KEGG:7332 ATLASONC:GC_UBE2L3 WIKI:UBE2L3 ubiquitin-conjugating enzyme E2L 4 HUGO:UBE2L4 HGNC:12489 ENTREZ:7333 GENECARDS:UBE2L4 WIKI:UBE2L4 ubiquitin-conjugating enzyme E2L 6 HUGO:UBE2L6 HGNC:12490 ENTREZ:9246 UNIPROT:O14933 GENECARDS:UBE2L6 REACTOME:66745 KEGG:9246 ATLASONC:GC_UBE2L6 WIKI:UBE2L6 ubiquitin-conjugating enzyme E2M HUGO:UBE2M HGNC:12491 ENTREZ:9040 UNIPROT:P61081 GENECARDS:UBE2M REACTOME:66777 KEGG:9040 ATLASONC:GC_UBE2M WIKI:UBE2M ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 GENECARDS:UBE2N REACTOME:66781 KEGG:7334 ATLASONC:GC_UBE2N WIKI:UBE2N ubiquitin-conjugating enzyme E2O HUGO:UBE2O HGNC:29554 ENTREZ:63893 UNIPROT:Q9C0C9 GENECARDS:UBE2O REACTOME:253534 KEGG:63893 ATLASONC:GC_UBE2O WIKI:UBE2O ubiquitin-conjugating enzyme E2Q family member 1 HUGO:UBE2Q1 HGNC:15698 ENTREZ:55585 UNIPROT:Q7Z7E8 GENECARDS:UBE2Q1 REACTOME:253474 KEGG:55585 ATLASONC:GC_UBE2Q1 WIKI:UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 2 HUGO:UBE2Q2 HGNC:19248 ENTREZ:92912 UNIPROT:Q8WVN8 GENECARDS:UBE2Q2 REACTOME:253479 ATLASONC:GC_UBE2Q2 WIKI:UBE2Q2 ubiquitin-conjugating enzyme E2R 2 HUGO:UBE2R2 HGNC:19907 ENTREZ:54926 UNIPROT:Q712K3 GENECARDS:UBE2R2 REACTOME:253483 KEGG:54926 ATLASONC:GC_UBE2R2 WIKI:UBE2R2 ubiquitin-conjugating enzyme E2S HUGO:UBE2S HGNC:17895 ENTREZ:27338 UNIPROT:Q16763 GENECARDS:UBE2S REACTOME:66751 KEGG:27338 ATLASONC:GC_UBE2S WIKI:UBE2S ubiquitin-conjugating enzyme E2Z HUGO:UBE2Z HGNC:25847 ENTREZ:65264 UNIPROT:Q9H832 GENECARDS:UBE2Z REACTOME:253545 KEGG:65264 WIKI:UBE2Z Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C ubiquitin-conjugating enzyme E2D 1 HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 ubiquitin-conjugating enzyme E2E 1 HUGO:UBE2E1 HGNC:12477 ENTREZ:7324 UNIPROT:P51965 GENECARDS:UBE2E1 REACTOME:66739 KEGG:7324 ATLASONC:GC_UBE2E1 WIKI:UBE2E1 ubiquitin-conjugating enzyme E2E 2 HUGO:UBE2E2 HGNC:12478 ENTREZ:7325 UNIPROT:Q96LR5 GENECARDS:UBE2E2 REACTOME:155471 KEGG:7325 ATLASONC:GC_UBE2E2 WIKI:UBE2E2 ubiquitin-conjugating enzyme E2G 1 HUGO:UBE2G1 HGNC:12482 ENTREZ:7326 UNIPROT:P62253 GENECARDS:UBE2G1 REACTOME:66753 KEGG:7326 ATLASONC:GC_UBE2G1 WIKI:UBE2G1 ubiquitin-conjugating enzyme E2G 2 HUGO:UBE2G2 HGNC:12483 ENTREZ:7327 UNIPROT:P60604 GENECARDS:UBE2G2 REACTOME:66773 KEGG:7327 ATLASONC:GC_UBE2G2 WIKI:UBE2G2 ubiquitin-conjugating enzyme E2H HUGO:UBE2H HGNC:12484 ENTREZ:7328 UNIPROT:P62256 GENECARDS:UBE2H REACTOME:66759 KEGG:7328 ATLASONC:GC_UBE2H WIKI:UBE2H ubiquitin-conjugating enzyme E2I HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I ubiquitin-conjugating enzyme E2 J1 HUGO:UBE2J1 HGNC:17598 ENTREZ:51465 UNIPROT:Q9Y385 GENECARDS:UBE2J1 REACTOME:155484 KEGG:51465 ATLASONC:GC_UBE2J1 WIKI:UBE2J1 ubiquitin-conjugating enzyme E2 J2 HUGO:UBE2J2 HGNC:19268 ENTREZ:118424 UNIPROT:Q8N2K1 GENECARDS:UBE2J2 REACTOME:155486 KEGG:118424 WIKI:UBE2J2 ubiquitin-conjugating enzyme E2K HUGO:UBE2K HGNC:4914 ENTREZ:3093 UNIPROT:P61086 GENECARDS:UBE2K REACTOME:66723 KEGG:3093 WIKI:UBE2K ubiquitin-conjugating enzyme E2L 3 HUGO:UBE2L3 HGNC:12488 ENTREZ:7332 UNIPROT:P68036 GENECARDS:UBE2L3 REACTOME:66741 KEGG:7332 ATLASONC:GC_UBE2L3 WIKI:UBE2L3 ubiquitin-conjugating enzyme E2L 4 HUGO:UBE2L4 HGNC:12489 ENTREZ:7333 GENECARDS:UBE2L4 WIKI:UBE2L4 ubiquitin-conjugating enzyme E2L 6 HUGO:UBE2L6 HGNC:12490 ENTREZ:9246 UNIPROT:O14933 GENECARDS:UBE2L6 REACTOME:66745 KEGG:9246 ATLASONC:GC_UBE2L6 WIKI:UBE2L6 ubiquitin-conjugating enzyme E2M HUGO:UBE2M HGNC:12491 ENTREZ:9040 UNIPROT:P61081 GENECARDS:UBE2M REACTOME:66777 KEGG:9040 ATLASONC:GC_UBE2M WIKI:UBE2M ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 GENECARDS:UBE2N REACTOME:66781 KEGG:7334 ATLASONC:GC_UBE2N WIKI:UBE2N ubiquitin-conjugating enzyme E2O HUGO:UBE2O HGNC:29554 ENTREZ:63893 UNIPROT:Q9C0C9 GENECARDS:UBE2O REACTOME:253534 KEGG:63893 ATLASONC:GC_UBE2O WIKI:UBE2O ubiquitin-conjugating enzyme E2Q family member 1 HUGO:UBE2Q1 HGNC:15698 ENTREZ:55585 UNIPROT:Q7Z7E8 GENECARDS:UBE2Q1 REACTOME:253474 KEGG:55585 ATLASONC:GC_UBE2Q1 WIKI:UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 2 HUGO:UBE2Q2 HGNC:19248 ENTREZ:92912 UNIPROT:Q8WVN8 GENECARDS:UBE2Q2 REACTOME:253479 ATLASONC:GC_UBE2Q2 WIKI:UBE2Q2 ubiquitin-conjugating enzyme E2R 2 HUGO:UBE2R2 HGNC:19907 ENTREZ:54926 UNIPROT:Q712K3 GENECARDS:UBE2R2 REACTOME:253483 KEGG:54926 ATLASONC:GC_UBE2R2 WIKI:UBE2R2 ubiquitin-conjugating enzyme E2S HUGO:UBE2S HGNC:17895 ENTREZ:27338 UNIPROT:Q16763 GENECARDS:UBE2S REACTOME:66751 KEGG:27338 ATLASONC:GC_UBE2S WIKI:UBE2S ubiquitin-conjugating enzyme E2Z HUGO:UBE2Z HGNC:25847 ENTREZ:65264 UNIPROT:Q9H832 GENECARDS:UBE2Z REACTOME:253545 KEGG:65264 WIKI:UBE2Z Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> </notes> <label text="E2*"/> <clone/> <bbox w="80.0" h="40.0" x="19074.0" y="2315.0"/> </glyph> <glyph class="macromolecule" id="shh1_s640_shh1_shh1_sa281" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: s_shh1_re92:(MAP:survival) PMID:18997815 s_akt2_re91:(MAP:survival) PMID:15668399 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C ubiquitin-conjugating enzyme E2D 1 HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 ubiquitin-conjugating enzyme E2E 1 HUGO:UBE2E1 HGNC:12477 ENTREZ:7324 UNIPROT:P51965 GENECARDS:UBE2E1 REACTOME:66739 KEGG:7324 ATLASONC:GC_UBE2E1 WIKI:UBE2E1 ubiquitin-conjugating enzyme E2E 2 HUGO:UBE2E2 HGNC:12478 ENTREZ:7325 UNIPROT:Q96LR5 GENECARDS:UBE2E2 REACTOME:155471 KEGG:7325 ATLASONC:GC_UBE2E2 WIKI:UBE2E2 ubiquitin-conjugating enzyme E2G 1 HUGO:UBE2G1 HGNC:12482 ENTREZ:7326 UNIPROT:P62253 GENECARDS:UBE2G1 REACTOME:66753 KEGG:7326 ATLASONC:GC_UBE2G1 WIKI:UBE2G1 ubiquitin-conjugating enzyme E2G 2 HUGO:UBE2G2 HGNC:12483 ENTREZ:7327 UNIPROT:P60604 GENECARDS:UBE2G2 REACTOME:66773 KEGG:7327 ATLASONC:GC_UBE2G2 WIKI:UBE2G2 ubiquitin-conjugating enzyme E2H HUGO:UBE2H HGNC:12484 ENTREZ:7328 UNIPROT:P62256 GENECARDS:UBE2H REACTOME:66759 KEGG:7328 ATLASONC:GC_UBE2H WIKI:UBE2H ubiquitin-conjugating enzyme E2I HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I ubiquitin-conjugating enzyme E2 J1 HUGO:UBE2J1 HGNC:17598 ENTREZ:51465 UNIPROT:Q9Y385 GENECARDS:UBE2J1 REACTOME:155484 KEGG:51465 ATLASONC:GC_UBE2J1 WIKI:UBE2J1 ubiquitin-conjugating enzyme E2 J2 HUGO:UBE2J2 HGNC:19268 ENTREZ:118424 UNIPROT:Q8N2K1 GENECARDS:UBE2J2 REACTOME:155486 KEGG:118424 WIKI:UBE2J2 ubiquitin-conjugating enzyme E2K HUGO:UBE2K HGNC:4914 ENTREZ:3093 UNIPROT:P61086 GENECARDS:UBE2K REACTOME:66723 KEGG:3093 WIKI:UBE2K ubiquitin-conjugating enzyme E2L 3 HUGO:UBE2L3 HGNC:12488 ENTREZ:7332 UNIPROT:P68036 GENECARDS:UBE2L3 REACTOME:66741 KEGG:7332 ATLASONC:GC_UBE2L3 WIKI:UBE2L3 ubiquitin-conjugating enzyme E2L 4 HUGO:UBE2L4 HGNC:12489 ENTREZ:7333 GENECARDS:UBE2L4 WIKI:UBE2L4 ubiquitin-conjugating enzyme E2L 6 HUGO:UBE2L6 HGNC:12490 ENTREZ:9246 UNIPROT:O14933 GENECARDS:UBE2L6 REACTOME:66745 KEGG:9246 ATLASONC:GC_UBE2L6 WIKI:UBE2L6 ubiquitin-conjugating enzyme E2M HUGO:UBE2M HGNC:12491 ENTREZ:9040 UNIPROT:P61081 GENECARDS:UBE2M REACTOME:66777 KEGG:9040 ATLASONC:GC_UBE2M WIKI:UBE2M ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 GENECARDS:UBE2N REACTOME:66781 KEGG:7334 ATLASONC:GC_UBE2N WIKI:UBE2N ubiquitin-conjugating enzyme E2O HUGO:UBE2O HGNC:29554 ENTREZ:63893 UNIPROT:Q9C0C9 GENECARDS:UBE2O REACTOME:253534 KEGG:63893 ATLASONC:GC_UBE2O WIKI:UBE2O ubiquitin-conjugating enzyme E2Q family member 1 HUGO:UBE2Q1 HGNC:15698 ENTREZ:55585 UNIPROT:Q7Z7E8 GENECARDS:UBE2Q1 REACTOME:253474 KEGG:55585 ATLASONC:GC_UBE2Q1 WIKI:UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 2 HUGO:UBE2Q2 HGNC:19248 ENTREZ:92912 UNIPROT:Q8WVN8 GENECARDS:UBE2Q2 REACTOME:253479 ATLASONC:GC_UBE2Q2 WIKI:UBE2Q2 ubiquitin-conjugating enzyme E2R 2 HUGO:UBE2R2 HGNC:19907 ENTREZ:54926 UNIPROT:Q712K3 GENECARDS:UBE2R2 REACTOME:253483 KEGG:54926 ATLASONC:GC_UBE2R2 WIKI:UBE2R2 ubiquitin-conjugating enzyme E2S HUGO:UBE2S HGNC:17895 ENTREZ:27338 UNIPROT:Q16763 GENECARDS:UBE2S REACTOME:66751 KEGG:27338 ATLASONC:GC_UBE2S WIKI:UBE2S ubiquitin-conjugating enzyme E2Z HUGO:UBE2Z HGNC:25847 ENTREZ:65264 UNIPROT:Q9H832 GENECARDS:UBE2Z REACTOME:253545 KEGG:65264 WIKI:UBE2Z Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C ubiquitin-conjugating enzyme E2D 1 HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 ubiquitin-conjugating enzyme E2E 1 HUGO:UBE2E1 HGNC:12477 ENTREZ:7324 UNIPROT:P51965 GENECARDS:UBE2E1 REACTOME:66739 KEGG:7324 ATLASONC:GC_UBE2E1 WIKI:UBE2E1 ubiquitin-conjugating enzyme E2E 2 HUGO:UBE2E2 HGNC:12478 ENTREZ:7325 UNIPROT:Q96LR5 GENECARDS:UBE2E2 REACTOME:155471 KEGG:7325 ATLASONC:GC_UBE2E2 WIKI:UBE2E2 ubiquitin-conjugating enzyme E2G 1 HUGO:UBE2G1 HGNC:12482 ENTREZ:7326 UNIPROT:P62253 GENECARDS:UBE2G1 REACTOME:66753 KEGG:7326 ATLASONC:GC_UBE2G1 WIKI:UBE2G1 ubiquitin-conjugating enzyme E2G 2 HUGO:UBE2G2 HGNC:12483 ENTREZ:7327 UNIPROT:P60604 GENECARDS:UBE2G2 REACTOME:66773 KEGG:7327 ATLASONC:GC_UBE2G2 WIKI:UBE2G2 ubiquitin-conjugating enzyme E2H HUGO:UBE2H HGNC:12484 ENTREZ:7328 UNIPROT:P62256 GENECARDS:UBE2H REACTOME:66759 KEGG:7328 ATLASONC:GC_UBE2H WIKI:UBE2H ubiquitin-conjugating enzyme E2I HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I ubiquitin-conjugating enzyme E2 J1 HUGO:UBE2J1 HGNC:17598 ENTREZ:51465 UNIPROT:Q9Y385 GENECARDS:UBE2J1 REACTOME:155484 KEGG:51465 ATLASONC:GC_UBE2J1 WIKI:UBE2J1 ubiquitin-conjugating enzyme E2 J2 HUGO:UBE2J2 HGNC:19268 ENTREZ:118424 UNIPROT:Q8N2K1 GENECARDS:UBE2J2 REACTOME:155486 KEGG:118424 WIKI:UBE2J2 ubiquitin-conjugating enzyme E2K HUGO:UBE2K HGNC:4914 ENTREZ:3093 UNIPROT:P61086 GENECARDS:UBE2K REACTOME:66723 KEGG:3093 WIKI:UBE2K ubiquitin-conjugating enzyme E2L 3 HUGO:UBE2L3 HGNC:12488 ENTREZ:7332 UNIPROT:P68036 GENECARDS:UBE2L3 REACTOME:66741 KEGG:7332 ATLASONC:GC_UBE2L3 WIKI:UBE2L3 ubiquitin-conjugating enzyme E2L 4 HUGO:UBE2L4 HGNC:12489 ENTREZ:7333 GENECARDS:UBE2L4 WIKI:UBE2L4 ubiquitin-conjugating enzyme E2L 6 HUGO:UBE2L6 HGNC:12490 ENTREZ:9246 UNIPROT:O14933 GENECARDS:UBE2L6 REACTOME:66745 KEGG:9246 ATLASONC:GC_UBE2L6 WIKI:UBE2L6 ubiquitin-conjugating enzyme E2M HUGO:UBE2M HGNC:12491 ENTREZ:9040 UNIPROT:P61081 GENECARDS:UBE2M REACTOME:66777 KEGG:9040 ATLASONC:GC_UBE2M WIKI:UBE2M ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 GENECARDS:UBE2N REACTOME:66781 KEGG:7334 ATLASONC:GC_UBE2N WIKI:UBE2N ubiquitin-conjugating enzyme E2O HUGO:UBE2O HGNC:29554 ENTREZ:63893 UNIPROT:Q9C0C9 GENECARDS:UBE2O REACTOME:253534 KEGG:63893 ATLASONC:GC_UBE2O WIKI:UBE2O ubiquitin-conjugating enzyme E2Q family member 1 HUGO:UBE2Q1 HGNC:15698 ENTREZ:55585 UNIPROT:Q7Z7E8 GENECARDS:UBE2Q1 REACTOME:253474 KEGG:55585 ATLASONC:GC_UBE2Q1 WIKI:UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 2 HUGO:UBE2Q2 HGNC:19248 ENTREZ:92912 UNIPROT:Q8WVN8 GENECARDS:UBE2Q2 REACTOME:253479 ATLASONC:GC_UBE2Q2 WIKI:UBE2Q2 ubiquitin-conjugating enzyme E2R 2 HUGO:UBE2R2 HGNC:19907 ENTREZ:54926 UNIPROT:Q712K3 GENECARDS:UBE2R2 REACTOME:253483 KEGG:54926 ATLASONC:GC_UBE2R2 WIKI:UBE2R2 ubiquitin-conjugating enzyme E2S HUGO:UBE2S HGNC:17895 ENTREZ:27338 UNIPROT:Q16763 GENECARDS:UBE2S REACTOME:66751 KEGG:27338 ATLASONC:GC_UBE2S WIKI:UBE2S ubiquitin-conjugating enzyme E2Z HUGO:UBE2Z HGNC:25847 ENTREZ:65264 UNIPROT:Q9H832 GENECARDS:UBE2Z REACTOME:253545 KEGG:65264 WIKI:UBE2Z Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end Identifiers_begin: ubiquitin-conjugating enzyme E2A HUGO:UBE2A HGNC:12472 ENTREZ:7319 UNIPROT:P49459 GENECARDS:UBE2A REACTOME:66747 KEGG:7319 ATLASONC:GC_UBE2A WIKI:UBE2A ubiquitin-conjugating enzyme E2B HUGO:UBE2B HGNC:12473 ENTREZ:7320 UNIPROT:P63146 GENECARDS:UBE2B REACTOME:66729 KEGG:7320 ATLASONC:GC_UBE2B WIKI:UBE2B ubiquitin-conjugating enzyme E2C HUGO:UBE2C HGNC:15937 ENTREZ:11065 UNIPROT:O00762 GENECARDS:UBE2C REACTOME:69954 KEGG:11065 ATLASONC:UBE2CID44079ch20q13 WIKI:UBE2C ubiquitin-conjugating enzyme E2D 1 HUGO:UBE2D1 HGNC:12474 ENTREZ:7321 UNIPROT:P51668 GENECARDS:UBE2D1 REACTOME:66705 KEGG:7321 ATLASONC:GC_UBE2D1 WIKI:UBE2D1 ubiquitin-conjugating enzyme E2D 2 HUGO:UBE2D2 HGNC:12475 ENTREZ:7322 UNIPROT:P62837 GENECARDS:UBE2D2 REACTOME:66707 KEGG:7322 ATLASONC:GC_UBE2D2 WIKI:UBE2D2 ubiquitin-conjugating enzyme E2D 3 HUGO:UBE2D3 HGNC:12476 ENTREZ:7323 UNIPROT:P61077 GENECARDS:UBE2D3 REACTOME:66715 KEGG:7323 ATLASONC:GC_UBE2D3 WIKI:UBE2D3 ubiquitin-conjugating enzyme E2E 1 HUGO:UBE2E1 HGNC:12477 ENTREZ:7324 UNIPROT:P51965 GENECARDS:UBE2E1 REACTOME:66739 KEGG:7324 ATLASONC:GC_UBE2E1 WIKI:UBE2E1 ubiquitin-conjugating enzyme E2E 2 HUGO:UBE2E2 HGNC:12478 ENTREZ:7325 UNIPROT:Q96LR5 GENECARDS:UBE2E2 REACTOME:155471 KEGG:7325 ATLASONC:GC_UBE2E2 WIKI:UBE2E2 ubiquitin-conjugating enzyme E2G 1 HUGO:UBE2G1 HGNC:12482 ENTREZ:7326 UNIPROT:P62253 GENECARDS:UBE2G1 REACTOME:66753 KEGG:7326 ATLASONC:GC_UBE2G1 WIKI:UBE2G1 ubiquitin-conjugating enzyme E2G 2 HUGO:UBE2G2 HGNC:12483 ENTREZ:7327 UNIPROT:P60604 GENECARDS:UBE2G2 REACTOME:66773 KEGG:7327 ATLASONC:GC_UBE2G2 WIKI:UBE2G2 ubiquitin-conjugating enzyme E2H HUGO:UBE2H HGNC:12484 ENTREZ:7328 UNIPROT:P62256 GENECARDS:UBE2H REACTOME:66759 KEGG:7328 ATLASONC:GC_UBE2H WIKI:UBE2H ubiquitin-conjugating enzyme E2I HUGO:UBE2I HGNC:12485 ENTREZ:7329 UNIPROT:P63279 GENECARDS:UBE2I REACTOME:66763 KEGG:7329 ATLASONC:GC_UBE2I WIKI:UBE2I ubiquitin-conjugating enzyme E2 J1 HUGO:UBE2J1 HGNC:17598 ENTREZ:51465 UNIPROT:Q9Y385 GENECARDS:UBE2J1 REACTOME:155484 KEGG:51465 ATLASONC:GC_UBE2J1 WIKI:UBE2J1 ubiquitin-conjugating enzyme E2 J2 HUGO:UBE2J2 HGNC:19268 ENTREZ:118424 UNIPROT:Q8N2K1 GENECARDS:UBE2J2 REACTOME:155486 KEGG:118424 WIKI:UBE2J2 ubiquitin-conjugating enzyme E2K HUGO:UBE2K HGNC:4914 ENTREZ:3093 UNIPROT:P61086 GENECARDS:UBE2K REACTOME:66723 KEGG:3093 WIKI:UBE2K ubiquitin-conjugating enzyme E2L 3 HUGO:UBE2L3 HGNC:12488 ENTREZ:7332 UNIPROT:P68036 GENECARDS:UBE2L3 REACTOME:66741 KEGG:7332 ATLASONC:GC_UBE2L3 WIKI:UBE2L3 ubiquitin-conjugating enzyme E2L 4 HUGO:UBE2L4 HGNC:12489 ENTREZ:7333 GENECARDS:UBE2L4 WIKI:UBE2L4 ubiquitin-conjugating enzyme E2L 6 HUGO:UBE2L6 HGNC:12490 ENTREZ:9246 UNIPROT:O14933 GENECARDS:UBE2L6 REACTOME:66745 KEGG:9246 ATLASONC:GC_UBE2L6 WIKI:UBE2L6 ubiquitin-conjugating enzyme E2M HUGO:UBE2M HGNC:12491 ENTREZ:9040 UNIPROT:P61081 GENECARDS:UBE2M REACTOME:66777 KEGG:9040 ATLASONC:GC_UBE2M WIKI:UBE2M ubiquitin-conjugating enzyme E2N HUGO:UBE2N HGNC:12492 ENTREZ:7334 UNIPROT:P61088 GENECARDS:UBE2N REACTOME:66781 KEGG:7334 ATLASONC:GC_UBE2N WIKI:UBE2N ubiquitin-conjugating enzyme E2O HUGO:UBE2O HGNC:29554 ENTREZ:63893 UNIPROT:Q9C0C9 GENECARDS:UBE2O REACTOME:253534 KEGG:63893 ATLASONC:GC_UBE2O WIKI:UBE2O ubiquitin-conjugating enzyme E2Q family member 1 HUGO:UBE2Q1 HGNC:15698 ENTREZ:55585 UNIPROT:Q7Z7E8 GENECARDS:UBE2Q1 REACTOME:253474 KEGG:55585 ATLASONC:GC_UBE2Q1 WIKI:UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 2 HUGO:UBE2Q2 HGNC:19248 ENTREZ:92912 UNIPROT:Q8WVN8 GENECARDS:UBE2Q2 REACTOME:253479 ATLASONC:GC_UBE2Q2 WIKI:UBE2Q2 ubiquitin-conjugating enzyme E2R 2 HUGO:UBE2R2 HGNC:19907 ENTREZ:54926 UNIPROT:Q712K3 GENECARDS:UBE2R2 REACTOME:253483 KEGG:54926 ATLASONC:GC_UBE2R2 WIKI:UBE2R2 ubiquitin-conjugating enzyme E2S HUGO:UBE2S HGNC:17895 ENTREZ:27338 UNIPROT:Q16763 GENECARDS:UBE2S REACTOME:66751 KEGG:27338 ATLASONC:GC_UBE2S WIKI:UBE2S ubiquitin-conjugating enzyme E2Z HUGO:UBE2Z HGNC:25847 ENTREZ:65264 UNIPROT:Q9H832 GENECARDS:UBE2Z REACTOME:253545 KEGG:65264 WIKI:UBE2Z Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15340381 PMID:12820959 References_end</body> </html> </notes> <label text="E2*"/> <clone/> <bbox w="80.0" h="40.0" x="18175.5" y="1155.0"/> </glyph> <glyph class="macromolecule" id="shh1_s641_shh1_shh3_sa2" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re6:(MAP:survival) PMID:17430994 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Patched 1 HUGO:PTCH1 HGNC:9585 ENTREZ:5727 UNIPROT:Q13635 GENECARDS:PTCH1 REACTOME:62393 KEGG:5727 ATLASONC:PTCH100 WIKI:PTCH1 Patched 2 HUGO:PTCH2 HGNC:9586 ENTREZ:8643 UNIPROT:Q9Y6C5 GENECARDS:PTCH2 REACTOME:62395 KEGG:8643 ATLASONC:PTCH2ID41892ch1p34 WIKI:PTCH2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:10021362 PMID:17641202 References_end</body> </html> </notes> <label text="PTCH*"/> <clone/> <bbox w="78.0" h="114.0" x="19544.0" y="4925.0"/> <glyph class="unit of information" id="_014edcd1-b1ee-4a14-bc9b-b211ba6febca"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="19560.5" y="4920.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s641_shh1_shh3_sa38" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re6:(MAP:survival) PMID:17430994 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Patched 1 HUGO:PTCH1 HGNC:9585 ENTREZ:5727 UNIPROT:Q13635 GENECARDS:PTCH1 REACTOME:62393 KEGG:5727 ATLASONC:PTCH100 WIKI:PTCH1 Patched 2 HUGO:PTCH2 HGNC:9586 ENTREZ:8643 UNIPROT:Q9Y6C5 GENECARDS:PTCH2 REACTOME:62395 KEGG:8643 ATLASONC:PTCH2ID41892ch1p34 WIKI:PTCH2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:10021362 PMID:17641202 References_end</body> </html> </notes> <label text="PTCH*"/> <clone/> <bbox w="78.0" h="114.0" x="18021.5" y="4918.0"/> <glyph class="unit of information" id="_89e38639-a460-4562-8c65-6dc596d5b80b"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="18038.0" y="4913.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s642_shh1_shh3_sa57" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re13:(MAP:survival) PMID:12514186 PMID:18359851 s_shh3_re14:(MAP:survival) PMID:17549397 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Fes HUGO:FES HGNC:3657 ENTREZ:2242 UNIPROT:P07332 GENECARDS:FES REACTOME:54750 KEGG:2242 ATLASONC:GC_FES WIKI:FES Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17549397 PMID:19082481 PMID:11801735 PMID:12514186 References_end</body> </html> </notes> <label text="C-FES*"/> <clone/> <bbox w="80.0" h="40.0" x="18917.0" y="5413.0"/> <glyph class="state variable" id="_55d61734-c32c-4487-bccb-7171a756887d"> <state value="" variable="Y713"/> <bbox w="30.0" h="10.0" x="18902.492" y="5408.0"/> </glyph> <glyph class="state variable" id="_d1670982-b1f2-448c-821e-0ca1f9bc9c29"> <state value="" variable="Y811"/> <bbox w="30.0" h="10.0" x="18982.0" y="5408.215"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s642_shh1_shh3_sa58" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re13:(MAP:survival) PMID:12514186 PMID:18359851 s_shh3_re14:(MAP:survival) PMID:17549397 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Fes HUGO:FES HGNC:3657 ENTREZ:2242 UNIPROT:P07332 GENECARDS:FES REACTOME:54750 KEGG:2242 ATLASONC:GC_FES WIKI:FES Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17549397 PMID:19082481 PMID:11801735 PMID:12514186 References_end</body> </html> </notes> <label text="C-FES*"/> <clone/> <bbox w="80.0" h="40.0" x="19109.5" y="5413.0"/> <glyph class="state variable" id="_1b310824-ddb1-49bd-986d-270c159524b3"> <state value="" variable="Y713"/> <bbox w="30.0" h="10.0" x="19094.992" y="5408.0"/> </glyph> <glyph class="state variable" id="_a25c566a-d28c-440b-954d-e58335adb9b8"> <state value="" variable="Y811"/> <bbox w="30.0" h="10.0" x="19174.5" y="5408.215"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s644_shh1_shh3_sa82" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re21(MAP:survival): PMID:11955434 :Activation of P-Rex can be synergistically by PIP3 and Gi-proteins s_shh3_re19(MAP:survival): PMID:12829230 PMID:15967165 PMID:15611338 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 1 HUGO:PREX1 HGNC:32594 ENTREZ:57580 UNIPROT:Q8TCU6 GENECARDS:PREX1 KEGG:57580 ATLASONC:GC_PREX1 WIKI:PREX1 Phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 2 HUGO:PREX2 HGNC:22950 ENTREZ:80243 UNIPROT:Q70Z35 GENECARDS:PREX2 KEGG:80243 ATLASONC:GC_PREX2 WIKI:PREX2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11955434 PMID:21172654 References_end</body> </html> </notes> <label text="PREX*"/> <clone/> <bbox w="80.0" h="40.0" x="20305.5" y="5007.0"/> </glyph> <glyph class="macromolecule" id="shh1_s644_shh1_shh3_sa85" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re21(MAP:survival): PMID:11955434 :Activation of P-Rex can be synergistically by PIP3 and Gi-proteins s_shh3_re19(MAP:survival): PMID:12829230 PMID:15967165 PMID:15611338 References_end ----- content merged by Celldesigner to SBGN-ML translation ------ Identifiers_begin: Phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 1 HUGO:PREX1 HGNC:32594 ENTREZ:57580 UNIPROT:Q8TCU6 GENECARDS:PREX1 KEGG:57580 ATLASONC:GC_PREX1 WIKI:PREX1 Phosphatidylinositol-3,4,5-triphosphate-dependent Rac exchange factor 2 HUGO:PREX2 HGNC:22950 ENTREZ:80243 UNIPROT:Q70Z35 GENECARDS:PREX2 KEGG:80243 ATLASONC:GC_PREX2 WIKI:PREX2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11955434 PMID:21172654 References_end</body> </html> </notes> <label text="PREX*"/> <clone/> <bbox w="80.0" h="40.0" x="20305.5" y="5108.0"/> </glyph> <glyph class="macromolecule" id="shh1_s650_shh1_shh2_sa27" compartmentRef="shh1_shh2_c3_shh1_shh2_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 1 HUGO:GLI1 HGNC:4317 ENTREZ:2735 UNIPROT:P08151 GENECARDS:GLI1 KEGG:2735 ATLASONC:GLIID310ch12q13 WIKI:GLI1 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI1"/> <bbox w="80.0" h="40.0" x="17986.75" y="3448.0"/> <glyph class="state variable" id="_51fbcc6e-7cd1-452d-91eb-3df4ba8e0f75"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="17981.75" y="3443.0"/> </glyph> <glyph class="state variable" id="_04efdcba-3ceb-4593-8a75-11a5f5f8b7bc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="17981.75" y="3483.0"/> </glyph> <glyph class="state variable" id="_a80aacda-8364-41e8-a4ee-c46627f52ad5"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18061.75" y="3443.0"/> </glyph> <glyph class="state variable" id="_86616fa9-cbaa-41fe-9353-1fc9901a5cb8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18061.75" y="3483.0"/> </glyph> <glyph class="state variable" id="_c40684b7-62ee-469f-a524-7251e2ab624c"> <state value="" variable="T374"/> <bbox w="30.0" h="10.0" x="18051.13" y="3483.0"/> </glyph> <glyph class="state variable" id="_2ec3225a-14bd-484e-a3f8-f5ef6e44199e"> <state value="" variable="S640"/> <bbox w="30.0" h="10.0" x="17971.75" y="3482.7224"/> </glyph> <glyph class="state variable" id="_71548817-14d1-4bc8-887e-86b42f3213ad"> <state value="" variable="K518"/> <bbox w="30.0" h="10.0" x="17994.725" y="3483.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s651_shh1_shh2_sa32" compartmentRef="shh1_shh2_c3_shh1_shh2_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Protein kinase cAMP-depenedent catalytic alpha HUGO:PRKACA HGNC:9380 ENTREZ:5566 UNIPROT:P17612 GENECARDS:PRKACA REACTOME:57845 KEGG:5566 ATLASONC:GC_PRKACA WIKI:PRKACA Protein kinase cAMP-depenedent catalytic beta HUGO:PRKACB HGNC:9381 ENTREZ:5567 UNIPROT:P22694 GENECARDS:PRKACB REACTOME:57847 KEGG:5567 ATLASONC:GC_PRKACB WIKI:PRKACB Protein kinase cAMP-depenedent catalytic gamma HUGOPRKACG HGNC:9382 ENTREZ:5568 UNIPROT:P22612 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20027184 References_end</body> </html> </notes> <label text="PKA*"/> <bbox w="80.0" h="40.0" x="18102.0" y="3373.0"/> </glyph> <glyph class="macromolecule" id="shh1_s652_shh1_shh2_sa119" compartmentRef="shh1_shh2_c3_shh1_shh2_ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <bbox w="80.0" h="40.0" x="17988.0" y="4328.0"/> <glyph class="state variable" id="_27cb63a8-4f3b-4204-a839-709ca53610ea"> <state value="" variable="K257"/> <bbox w="30.0" h="10.0" x="17973.492" y="4323.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s656_shh1_shh1_csa16" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HH Ligand:PTCH* Identifiers_end References_begin: s_shh1_re27:(MAP:survival) PMID:17430994 References_end</body> </html> </notes> <label text="PTC_HH_ligand"/> <bbox w="126.0" h="281.0" x="18400.75" y="89.0"/> <glyph class="macromolecule" id="shh1_s657_shh1_shh1_sa137"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Patched 1 HUGO:PTCH1 HGNC:9585 ENTREZ:5727 UNIPROT:Q13635 GENECARDS:PTCH1 REACTOME:62393 KEGG:5727 ATLASONC:PTCH100 WIKI:PTCH1 Patched 2 HUGO:PTCH2 HGNC:9586 ENTREZ:8643 UNIPROT:Q9Y6C5 GENECARDS:PTCH2 REACTOME:62395 KEGG:8643 ATLASONC:PTCH2ID41892ch1p34 WIKI:PTCH2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:10021362 PMID:17641202 References_end</body> </html> </notes> <label text="PTCH*"/> <bbox w="78.0" h="114.0" x="18426.25" y="116.0"/> <glyph class="unit of information" id="_4d37ac21-279c-47d1-af4c-94cd6d092124"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="18442.75" y="111.0"/> </glyph> </glyph> <glyph class="simple chemical" id="shh1_s658_shh1_shh1_sa138"> <label text="HH Ligand"/> <bbox w="70.0" h="25.0" x="18429.25" y="105.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s282_shh1_shh1_sa139"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Smoothened HUGO:SMO HGNC:11119 ENTREZ:6608 UNIPROT:Q99835 GENECARDS:SMO REACTOME:64670 KEGG:6608 ATLASONC:GC_SMO WIKI:SMO Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18820483 PMID:17641202 Smoothened homologue (Drosophila) References_end</body> </html> </notes> <label text="SMO"/> <bbox w="80.0" h="40.0" x="18423.5" y="231.0"/> <glyph class="state variable" id="_91cbad92-6b0b-414d-b5c1-7c1e2ccda4e8"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18498.5" y="226.0"/> </glyph> <glyph class="state variable" id="_e747a631-a6e9-4acc-92b6-3f8ce0ab267a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18498.5" y="226.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s585_shh1_shh1_sa340"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 Guanine nucleotide binding protein (G-protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 Guanine nucleotide binding protein (G-protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17430994 Guanine nucleotide binding protein (G-protein) References_end</body> </html> </notes> <label text="Gαi*"/> <bbox w="40.0" h="30.0" x="18403.5" y="281.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s586_shh1_shh1_sa342"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein) beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein) beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein) beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein) beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein) beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17430994 References_end</body> </html> </notes> <label text="Gβi*"/> <bbox w="40.0" h="30.0" x="18443.0" y="281.0"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s587_shh1_shh1_sa344"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein) gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein) gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein) gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein) gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein) gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein) gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein) gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein) gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein) gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein) gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17430994 References_end</body> </html> </notes> <label text="Gγi*"/> <bbox w="40.0" h="30.0" x="18482.5" y="281.0"/> </glyph> <glyph class="simple chemical" id="shh1_shh1_s594_shh1_shh1_sa349"> <label text="GTP"/> <bbox w="30.0" h="30.0" x="18405.5" y="312.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s662_shh1_shh1_csa37" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GLI2-185*:SUFU:ULK3 Identifiers_end References_begin: s_shh1_re72:(MAP:survival) PMID:16611981 References_end</body> </html> </notes> <label text="Gli2-185_SUFU_ULK3"/> <bbox w="193.0" h="148.0" x="18592.875" y="1933.0"/> <glyph class="macromolecule" id="shh1_s663_shh1_shh1_sa239"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Unc-51-like kinase 3 HUGO:ULK3 HGNC:19703 ENTREZ:25989 UNIPROT:Q6PHR2 GENECARDS:ULK3 ATLASONC:GC_ULK3 WIKI:ULK3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Unc-51-like kinase PMID:20643644 PMID:19878745 References_end</body> </html> </notes> <label text="ULK3"/> <bbox w="80.0" h="40.0" x="18693.625" y="1956.0"/> <glyph class="state variable" id="_1df74460-fd75-4e62-b2be-346aed629be2"> <state value="" variable="S384"/> <bbox w="30.0" h="10.0" x="18758.006" y="1991.0"/> </glyph> <glyph class="state variable" id="_4f11e871-5de9-4580-aeca-b2dc3ee0fa0c"> <state value="" variable="S464"/> <bbox w="30.0" h="10.0" x="18678.625" y="1990.7223"/> </glyph> <glyph class="state variable" id="_1433d491-0a99-45da-ab1c-413923be5a35"> <state value="" variable="S300"/> <bbox w="30.0" h="10.0" x="18679.117" y="1951.0"/> </glyph> <glyph class="state variable" id="_1e76f1ce-afcb-4dee-9ea1-196d0546eb75"> <state value="" variable="S350"/> <bbox w="30.0" h="10.0" x="18758.625" y="1951.2147"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s664_shh1_shh1_sa240"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <bbox w="80.0" h="40.0" x="18605.125" y="1956.0"/> <glyph class="state variable" id="_f068a6fd-6330-43c8-8c06-73b3d1bd079b"> <state value="" variable="K257"/> <bbox w="30.0" h="10.0" x="18590.617" y="1951.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s429_shh1_shh1_sa241"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 2 HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Glioma-associated oncogene family zinc finger PMID:18497536 PMID:17845852 PMID:11001584 References_end</body> </html> </notes> <label text="GLI2-185*"/> <bbox w="165.0" h="45.0" x="18606.625" y="2010.0"/> <glyph class="state variable" id="_3e5674ba-66a8-4e1a-bc52-9e6df48ddde2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18656.857" y="2005.0"/> </glyph> <glyph class="state variable" id="_0d94f925-a360-42d7-aa9e-56ce3fdb5c98"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18698.354" y="2005.0"/> </glyph> <glyph class="state variable" id="_2e86ea3d-1fdc-4061-8474-1313becea3ea"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18704.98" y="2050.0"/> </glyph> <glyph class="state variable" id="_b6981777-77bc-49e2-9696-121713cab213"> <state value="P" variable="S801"/> <bbox w="35.0" h="10.0" x="18657.531" y="2005.0"/> </glyph> <glyph class="state variable" id="_7bc21df4-7585-4bb3-a3a0-e3ab05e3dff3"> <state value="" variable="K757"/> <bbox w="30.0" h="10.0" x="18591.625" y="2018.99"/> </glyph> <glyph class="state variable" id="_7f123ac4-fab7-426b-a163-34ab29803cca"> <state value="" variable="S956"/> <bbox w="30.0" h="10.0" x="18591.625" y="2049.6875"/> </glyph> <glyph class="state variable" id="_94b08686-9b9c-4a74-9b9b-4dadd58cf113"> <state value="" variable="S817"/> <bbox w="30.0" h="10.0" x="18755.35" y="2050.0"/> </glyph> <glyph class="state variable" id="_71541bc5-c5a9-4b32-a2ad-ed6a2688b74e"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="18679.125" y="2005.0"/> </glyph> <glyph class="state variable" id="_c9a20440-a7f1-41cd-b7dd-665eb7ff026e"> <state value="" variable="S847"/> <bbox w="30.0" h="10.0" x="18642.846" y="2050.0"/> </glyph> <glyph class="state variable" id="_f57a38b6-4b61-4c50-97e8-a7022ac34ce8"> <state value="P" variable="S385"/> <bbox w="35.0" h="10.0" x="18589.125" y="2027.4641"/> </glyph> <glyph class="state variable" id="_5d231b1d-4988-4a0b-a14f-00f044292706"> <state value="" variable="S789"/> <bbox w="30.0" h="10.0" x="18591.625" y="2018.4717"/> </glyph> <glyph class="state variable" id="_3c48d859-b895-4ded-a24c-fec4bac06121"> <state value="P" variable="S1011"/> <bbox w="40.0" h="10.0" x="18586.625" y="2035.4188"/> </glyph> <glyph class="state variable" id="_488e0b26-87b6-46b4-ab12-27b07a682b28"> <state value="" variable="S805"/> <bbox w="30.0" h="10.0" x="18695.26" y="2005.0"/> </glyph> <glyph class="state variable" id="_f5fa6122-41a3-4c60-bc84-f46377b8e2b8"> <state value="P" variable="S820"/> <bbox w="35.0" h="10.0" x="18717.514" y="2050.0"/> </glyph> <glyph class="state variable" id="_7f508480-ad15-468d-ba48-e2e7e9b2954f"> <state value="P" variable="S813"/> <bbox w="35.0" h="10.0" x="18754.125" y="2027.5717"/> </glyph> <glyph class="state variable" id="_b0f2a2cb-b3ed-4271-97e9-a1e339e7f399"> <state value="P" variable="S850"/> <bbox w="35.0" h="10.0" x="18589.125" y="2048.8171"/> </glyph> <glyph class="state variable" id="_0f42e616-a218-401a-95bb-a82e00fe6c44"> <state value="P" variable="S844"/> <bbox w="35.0" h="10.0" x="18666.47" y="2050.0"/> </glyph> <glyph class="state variable" id="_c1f7acd4-d4dd-41da-a598-2ca38bda634d"> <state value="P" variable="S792"/> <bbox w="35.0" h="10.0" x="18590.14" y="2005.0"/> </glyph> <glyph class="state variable" id="_ffc44ee7-28e2-4486-bf9f-f46b5293d006"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="18702.48" y="2050.0"/> </glyph> <glyph class="state variable" id="_9936f28e-98bc-47f2-9da5-64815f25a52a"> <state value="P" variable="S808"/> <bbox w="35.0" h="10.0" x="18753.37" y="2005.0"/> </glyph> <glyph class="state variable" id="_727898bb-6e61-4b8a-9140-54dea5ec6bb6"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="18640.365" y="2005.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s394_shh1_shh1_csa32" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GLI2-185*:SUFU:ULK3 Identifiers_end References_begin: s_shh1_re64(MAP:survival): PMID:16611981 PMID:16651270 Gli2 ubi by bTrCP2 References_end</body> </html> </notes> <label text="Gli2-185_SUFU_ULK3"/> <bbox w="196.0" h="150.0" x="18344.5" y="1249.0"/> <glyph class="macromolecule" id="shh1_shh1_s411_shh1_shh1_sa61"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 2 HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Glioma-associated oncogene family zinc finger PMID:18497536 PMID:17845852 PMID:11001584 References_end</body> </html> </notes> <label text="GLI2-185*"/> <bbox w="162.0" h="38.0" x="18358.75" y="1333.5"/> <glyph class="state variable" id="_9d74c8f2-486b-4515-8c31-67a586ae48e7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18407.979" y="1328.5"/> </glyph> <glyph class="state variable" id="_5b1cbd7f-4753-44c3-bfcb-d6e277d0ddff"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18448.72" y="1328.5"/> </glyph> <glyph class="state variable" id="_4a96aa53-1298-4e0f-a9dc-a62b6dc46988"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18455.227" y="1366.5"/> </glyph> <glyph class="state variable" id="_e7b254f9-8326-4edf-8be2-8fb728d62cf5"> <state value="P" variable="S801"/> <bbox w="35.0" h="10.0" x="18408.412" y="1328.5"/> </glyph> <glyph class="state variable" id="_b2d0daaa-c405-453f-adaa-6942dffbcd6a"> <state value="" variable="K757"/> <bbox w="30.0" h="10.0" x="18343.75" y="1340.3137"/> </glyph> <glyph class="state variable" id="_46a34003-f7bc-480f-8a20-04b1738006e0"> <state value="" variable="S956"/> <bbox w="30.0" h="10.0" x="18343.75" y="1366.2362"/> </glyph> <glyph class="state variable" id="_dca1c317-3563-4979-80f0-b0c6ac5a826c"> <state value="P" variable="S817"/> <bbox w="35.0" h="10.0" x="18501.998" y="1366.5"/> </glyph> <glyph class="state variable" id="_0a3f6b24-c6c4-4312-ac7d-d88640af4148"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="18429.75" y="1328.5"/> </glyph> <glyph class="state variable" id="_230c3039-44c6-4657-98cb-eb7dd9f47c15"> <state value="P" variable="S847"/> <bbox w="35.0" h="10.0" x="18391.541" y="1366.5"/> </glyph> <glyph class="state variable" id="_2c6f6cae-bc7c-41de-be81-351049616b1f"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="18343.75" y="1347.4697"/> </glyph> <glyph class="state variable" id="_4430bf6a-d0d9-401b-9a8d-0899dd74a040"> <state value="P" variable="S789"/> <bbox w="35.0" h="10.0" x="18341.25" y="1339.8761"/> </glyph> <glyph class="state variable" id="_ca527c5b-8775-4711-813f-bf43161a56dc"> <state value="" variable="S1011"/> <bbox w="35.0" h="10.0" x="18341.25" y="1354.187"/> </glyph> <glyph class="state variable" id="_5ef87923-f0cb-4b95-8a74-95065b0816f4"> <state value="P" variable="S805"/> <bbox w="35.0" h="10.0" x="18443.002" y="1328.5"/> </glyph> <glyph class="state variable" id="_27414883-c42c-4bf9-b32c-b627170990ec"> <state value="P" variable="S820"/> <bbox w="35.0" h="10.0" x="18467.305" y="1366.5"/> </glyph> <glyph class="state variable" id="_ab1df397-8643-44c0-b62f-9acf6c3c7144"> <state value="P" variable="S813"/> <bbox w="35.0" h="10.0" x="18503.25" y="1347.5605"/> </glyph> <glyph class="state variable" id="_ae373e07-335c-4408-9f4a-41b4da4cda6d"> <state value="P" variable="S850"/> <bbox w="35.0" h="10.0" x="18341.25" y="1365.5011"/> </glyph> <glyph class="state variable" id="_39430f88-09b7-43fb-9f31-171c9cc3d523"> <state value="P" variable="S844"/> <bbox w="35.0" h="10.0" x="18417.19" y="1366.5"/> </glyph> <glyph class="state variable" id="_de35adb7-6d7a-45a8-bb73-797283b0683e"> <state value="P" variable="S792"/> <bbox w="35.0" h="10.0" x="18342.248" y="1328.5"/> </glyph> <glyph class="state variable" id="_09b7fe98-e105-4820-a221-d41bbd5ae5d3"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="18452.727" y="1366.5"/> </glyph> <glyph class="state variable" id="_3014acfb-2bb8-4375-b467-199d308cc628"> <state value="P" variable="S808"/> <bbox w="35.0" h="10.0" x="18502.508" y="1328.5"/> </glyph> <glyph class="state variable" id="_b0657492-6daa-4da6-b2ca-aa2a065e5479"> <state value="Ub" variable=""/> <bbox w="20.0" h="10.0" x="18391.695" y="1328.5"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s395_shh1_shh1_sa224"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <bbox w="80.0" h="40.0" x="18356.75" y="1278.0"/> <glyph class="state variable" id="_e44d9526-6ecc-4b0c-a5fd-0c72a623331e"> <state value="" variable="K257"/> <bbox w="30.0" h="10.0" x="18342.242" y="1273.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s396_shh1_shh1_sa225"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Unc-51-like kinase 3 HUGO:ULK3 HGNC:19703 ENTREZ:25989 UNIPROT:Q6PHR2 GENECARDS:ULK3 ATLASONC:GC_ULK3 WIKI:ULK3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Unc-51-like kinase PMID:20643644 PMID:19878745 References_end</body> </html> </notes> <label text="ULK3"/> <bbox w="80.0" h="40.0" x="18445.25" y="1277.0"/> <glyph class="state variable" id="_1ca73f4d-a460-4dd7-9a4e-0f1e3bc3c79d"> <state value="" variable="S384"/> <bbox w="30.0" h="10.0" x="18509.63" y="1312.0"/> </glyph> <glyph class="state variable" id="_afecb7c3-74b8-4b9e-80a0-2fcecec9abf1"> <state value="" variable="S464"/> <bbox w="30.0" h="10.0" x="18430.25" y="1311.7223"/> </glyph> <glyph class="state variable" id="_bc35e5a7-5433-4ecf-b9bc-82bfa643610c"> <state value="" variable="S300"/> <bbox w="30.0" h="10.0" x="18430.742" y="1272.0"/> </glyph> <glyph class="state variable" id="_c34a7b57-1c3d-4fae-9e81-abacc20995fc"> <state value="" variable="S350"/> <bbox w="30.0" h="10.0" x="18510.25" y="1272.2147"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s636_shh1_shh1_csa29" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GLI2-185*:SUFU:ULK3 Identifiers_end References_begin: s_shh1_re68:(MAP:survival) PMID:18455992 References_end</body> </html> </notes> <label text="Gli2-185_SUFU_ULK3"/> <clone/> <bbox w="193.0" h="148.0" x="18003.0" y="984.0"/> <glyph class="macromolecule" id="shh1_s647_shh1_shh1_sa213"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 2 HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Glioma-associated oncogene family zinc finger PMID:18497536 PMID:17845852 PMID:11001584 References_end</body> </html> </notes> <label text="GLI2-185*"/> <clone/> <bbox w="165.0" h="45.0" x="18016.75" y="1061.0"/> <glyph class="state variable" id="_c5c52ec5-45cc-4499-a7de-1b5062eb3359"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18066.982" y="1056.0"/> </glyph> <glyph class="state variable" id="_5dc6db34-1a4d-45e2-8ae4-c35315624e03"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18108.479" y="1056.0"/> </glyph> <glyph class="state variable" id="_fc04b681-2a58-4cea-9d23-2b84bcd45d8e"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18115.105" y="1101.0"/> </glyph> <glyph class="state variable" id="_c25496b3-0ae8-434c-ade1-58cf1ae8e4f2"> <state value="" variable="S801"/> <bbox w="30.0" h="10.0" x="18070.156" y="1056.0"/> </glyph> <glyph class="state variable" id="_44902940-99e1-4a52-a413-f2a3bbe4e4c5"> <state value="" variable="K757"/> <bbox w="30.0" h="10.0" x="18001.75" y="1069.99"/> </glyph> <glyph class="state variable" id="_ab323ce7-f215-45c4-8621-48def532a557"> <state value="" variable="S956"/> <bbox w="30.0" h="10.0" x="18001.75" y="1100.6876"/> </glyph> <glyph class="state variable" id="_177595c5-97c4-4d17-9c31-9264ce4d8e6a"> <state value="" variable="S817"/> <bbox w="30.0" h="10.0" x="18165.475" y="1101.0"/> </glyph> <glyph class="state variable" id="_90488587-ea60-4977-b1f5-aa614a6c1986"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18094.25" y="1056.0"/> </glyph> <glyph class="state variable" id="_d004141c-fa39-4f82-8db4-f732a8de1c70"> <state value="" variable="S847"/> <bbox w="30.0" h="10.0" x="18052.97" y="1101.0"/> </glyph> <glyph class="state variable" id="_afcba4d7-7944-4fdc-b063-1f76459032e2"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="18001.75" y="1078.4641"/> </glyph> <glyph class="state variable" id="_fced2446-e011-4885-9aab-ca2fd1eacb37"> <state value="" variable="S789"/> <bbox w="30.0" h="10.0" x="18001.75" y="1069.4717"/> </glyph> <glyph class="state variable" id="_7361f9dd-f6eb-41f4-9402-9a58cace5029"> <state value="" variable="S1011"/> <bbox w="35.0" h="10.0" x="17999.25" y="1086.4188"/> </glyph> <glyph class="state variable" id="_faea357f-1fda-42ff-8134-4e7b3a36c321"> <state value="" variable="S805"/> <bbox w="30.0" h="10.0" x="18105.385" y="1056.0"/> </glyph> <glyph class="state variable" id="_c1a8879b-a9e8-4174-a713-917ae3b841af"> <state value="" variable="S820"/> <bbox w="30.0" h="10.0" x="18130.139" y="1101.0"/> </glyph> <glyph class="state variable" id="_e8f36051-1769-4310-bd94-1aa96d5a7076"> <state value="" variable="S813"/> <bbox w="30.0" h="10.0" x="18166.75" y="1078.5717"/> </glyph> <glyph class="state variable" id="_aeec4ea8-63cf-4611-892f-fe7da8479d3e"> <state value="" variable="S850"/> <bbox w="30.0" h="10.0" x="18001.75" y="1099.817"/> </glyph> <glyph class="state variable" id="_566acfa2-eb2c-4635-9ea4-8b5706cffaa4"> <state value="" variable="S844"/> <bbox w="30.0" h="10.0" x="18079.096" y="1101.0"/> </glyph> <glyph class="state variable" id="_bc3b600d-9e51-4882-a7e9-4f84432ab4c3"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="18002.766" y="1056.0"/> </glyph> <glyph class="state variable" id="_bb0ca4e9-4a59-44ab-9cbd-46f313ba7229"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18115.105" y="1101.0"/> </glyph> <glyph class="state variable" id="_e64151b5-da63-42a7-832f-63752ecb4adb"> <state value="" variable="S808"/> <bbox w="30.0" h="10.0" x="18165.994" y="1056.0"/> </glyph> <glyph class="state variable" id="_890f5bb4-a9e6-4702-869b-2e6238757fb0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18055.49" y="1056.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s648_shh1_shh1_sa214"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Unc-51-like kinase 3 HUGO:ULK3 HGNC:19703 ENTREZ:25989 UNIPROT:Q6PHR2 GENECARDS:ULK3 ATLASONC:GC_ULK3 WIKI:ULK3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Unc-51-like kinase PMID:20643644 PMID:19878745 References_end</body> </html> </notes> <label text="ULK3"/> <clone/> <bbox w="80.0" h="40.0" x="18103.75" y="1010.0"/> <glyph class="state variable" id="_ee5a45ee-e1f8-458e-8872-92ad7f71c04f"> <state value="" variable="S384"/> <bbox w="30.0" h="10.0" x="18168.13" y="1045.0"/> </glyph> <glyph class="state variable" id="_34b3a824-ab0d-4bdc-86de-ab5987fe40f8"> <state value="" variable="S464"/> <bbox w="30.0" h="10.0" x="18088.75" y="1044.7223"/> </glyph> <glyph class="state variable" id="_142fdafb-44aa-4a4c-9d24-0728ae7dd1fb"> <state value="" variable="S300"/> <bbox w="30.0" h="10.0" x="18089.242" y="1005.0"/> </glyph> <glyph class="state variable" id="_f44c92f8-674f-4c05-98b3-b01996e15dfb"> <state value="" variable="S350"/> <bbox w="30.0" h="10.0" x="18168.75" y="1005.2148"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s649_shh1_shh1_sa215"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <clone/> <bbox w="80.0" h="40.0" x="18018.25" y="1010.0"/> <glyph class="state variable" id="_7a81f099-d827-491e-84a8-657f4afa7824"> <state value="" variable="K257"/> <bbox w="30.0" h="10.0" x="18003.742" y="1005.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s636_shh1_shh1_csa34" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GLI2-185*:SUFU:ULK3 Identifiers_end References_begin: s_shh1_re68:(MAP:survival) PMID:18455992 References_end</body> </html> </notes> <label text="Gli2-185_SUFU_ULK3"/> <clone/> <bbox w="193.0" h="148.0" x="18588.5" y="1714.0"/> <glyph class="macromolecule" id="shh1_s647_shh1_shh1_sa230"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 2 HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Glioma-associated oncogene family zinc finger PMID:18497536 PMID:17845852 PMID:11001584 References_end</body> </html> </notes> <label text="GLI2-185*"/> <clone/> <bbox w="165.0" h="45.0" x="18602.25" y="1791.0"/> <glyph class="state variable" id="_c2882642-860f-4b43-b3d2-f247d78be4c2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18652.482" y="1786.0"/> </glyph> <glyph class="state variable" id="_ede5c2b0-c5b6-4a7e-9258-08a56ecb78a6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18693.979" y="1786.0"/> </glyph> <glyph class="state variable" id="_132707c1-bb0c-4d90-b87e-bfafc203760f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18700.605" y="1831.0"/> </glyph> <glyph class="state variable" id="_d4ec719a-7382-4bc1-a241-8ab855d60d48"> <state value="" variable="S801"/> <bbox w="30.0" h="10.0" x="18655.656" y="1786.0"/> </glyph> <glyph class="state variable" id="_60be2b1b-e109-40cc-a3b9-30a9a4d83827"> <state value="" variable="K757"/> <bbox w="30.0" h="10.0" x="18587.25" y="1799.99"/> </glyph> <glyph class="state variable" id="_ae7daea6-070c-4311-ac02-8eeab347f186"> <state value="" variable="S956"/> <bbox w="30.0" h="10.0" x="18587.25" y="1830.6876"/> </glyph> <glyph class="state variable" id="_97425dc3-f358-426b-aab4-5bf6c1598498"> <state value="" variable="S817"/> <bbox w="30.0" h="10.0" x="18750.975" y="1831.0"/> </glyph> <glyph class="state variable" id="_d407947f-59b9-4640-bfe5-62444f6d27f0"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18679.75" y="1786.0"/> </glyph> <glyph class="state variable" id="_8dd0d2ab-f771-4f96-b07d-5be2bf25cc01"> <state value="" variable="S847"/> <bbox w="30.0" h="10.0" x="18638.47" y="1831.0"/> </glyph> <glyph class="state variable" id="_09036c52-809e-41c9-8879-bd9577762528"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="18587.25" y="1808.4641"/> </glyph> <glyph class="state variable" id="_c0535464-9691-4041-bb49-8d877d012be2"> <state value="" variable="S789"/> <bbox w="30.0" h="10.0" x="18587.25" y="1799.4717"/> </glyph> <glyph class="state variable" id="_a26a01cd-380a-43ee-b693-7db46493343f"> <state value="" variable="S1011"/> <bbox w="35.0" h="10.0" x="18584.75" y="1816.4188"/> </glyph> <glyph class="state variable" id="_c003f9b1-ccbb-482a-b4d5-e480bf2c1a2d"> <state value="" variable="S805"/> <bbox w="30.0" h="10.0" x="18690.885" y="1786.0"/> </glyph> <glyph class="state variable" id="_d696d050-fad1-47aa-bde5-3655b1974a85"> <state value="" variable="S820"/> <bbox w="30.0" h="10.0" x="18715.639" y="1831.0"/> </glyph> <glyph class="state variable" id="_b4123d70-eb83-4c2f-86cf-4c093d9b8158"> <state value="" variable="S813"/> <bbox w="30.0" h="10.0" x="18752.25" y="1808.5717"/> </glyph> <glyph class="state variable" id="_23ff52e1-d874-4069-990f-b64c64d934a1"> <state value="" variable="S850"/> <bbox w="30.0" h="10.0" x="18587.25" y="1829.817"/> </glyph> <glyph class="state variable" id="_0561760c-a2ea-485b-ae85-97460157560e"> <state value="" variable="S844"/> <bbox w="30.0" h="10.0" x="18664.596" y="1831.0"/> </glyph> <glyph class="state variable" id="_ca785814-8cb4-4879-8c3c-b5465b19af32"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="18588.266" y="1786.0"/> </glyph> <glyph class="state variable" id="_248f9f60-8571-4c40-81a7-e179beffffec"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18700.605" y="1831.0"/> </glyph> <glyph class="state variable" id="_3625d21e-24cd-4779-bd21-6c3975a70d6b"> <state value="" variable="S808"/> <bbox w="30.0" h="10.0" x="18751.494" y="1786.0"/> </glyph> <glyph class="state variable" id="_9a719758-1cb3-4ef0-a715-a19d865f9ebe"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18640.99" y="1786.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s648_shh1_shh1_sa231"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Unc-51-like kinase 3 HUGO:ULK3 HGNC:19703 ENTREZ:25989 UNIPROT:Q6PHR2 GENECARDS:ULK3 ATLASONC:GC_ULK3 WIKI:ULK3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Unc-51-like kinase PMID:20643644 PMID:19878745 References_end</body> </html> </notes> <label text="ULK3"/> <clone/> <bbox w="80.0" h="40.0" x="18689.25" y="1740.0"/> <glyph class="state variable" id="_a0cba97f-7207-408e-b530-fead2edf1b7f"> <state value="" variable="S384"/> <bbox w="30.0" h="10.0" x="18753.63" y="1775.0"/> </glyph> <glyph class="state variable" id="_ca4ea8ce-7a18-47a7-815f-84a44fb5d031"> <state value="" variable="S464"/> <bbox w="30.0" h="10.0" x="18674.25" y="1774.7223"/> </glyph> <glyph class="state variable" id="_e35cc853-51f5-4f83-9dda-686b02000f37"> <state value="" variable="S300"/> <bbox w="30.0" h="10.0" x="18674.742" y="1735.0"/> </glyph> <glyph class="state variable" id="_bf872f7b-042a-4ecd-8602-753b588de479"> <state value="" variable="S350"/> <bbox w="30.0" h="10.0" x="18754.25" y="1735.2147"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s649_shh1_shh1_sa232"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <clone/> <bbox w="80.0" h="40.0" x="18603.75" y="1740.0"/> <glyph class="state variable" id="_4a32754d-6582-4211-8538-795d47c8373d"> <state value="" variable="K257"/> <bbox w="30.0" h="10.0" x="18589.242" y="1735.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s386_shh1_shh1_csa30" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GLI2-185*:SUFU:ULK3 Identifiers_end References_begin: s_shh1_re60:(MAP:survival) PMID:16611981 References_end</body> </html> </notes> <label text="Gli2-185_SUFU_ULK3"/> <bbox w="196.0" h="150.0" x="18282.75" y="983.0"/> <glyph class="macromolecule" id="shh1_shh1_s388_shh1_shh1_sa217"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <bbox w="80.0" h="40.0" x="18295.0" y="1012.0"/> <glyph class="state variable" id="_e4b83920-20f1-4f61-a543-39115ca79fc0"> <state value="" variable="K257"/> <bbox w="30.0" h="10.0" x="18280.492" y="1007.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s389_shh1_shh1_sa218"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Unc-51-like kinase 3 HUGO:ULK3 HGNC:19703 ENTREZ:25989 UNIPROT:Q6PHR2 GENECARDS:ULK3 ATLASONC:GC_ULK3 WIKI:ULK3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Unc-51-like kinase PMID:20643644 PMID:19878745 References_end</body> </html> </notes> <label text="ULK3"/> <bbox w="80.0" h="40.0" x="18383.5" y="1011.0"/> <glyph class="state variable" id="_1fb290dd-8597-438d-9218-4e8130cb1055"> <state value="" variable="S384"/> <bbox w="30.0" h="10.0" x="18447.88" y="1046.0"/> </glyph> <glyph class="state variable" id="_adc68774-2066-469e-a51c-9eff1327bee3"> <state value="" variable="S464"/> <bbox w="30.0" h="10.0" x="18368.5" y="1045.7223"/> </glyph> <glyph class="state variable" id="_daac0c39-bd3e-4c71-8a2e-3a22a8b958dd"> <state value="" variable="S300"/> <bbox w="30.0" h="10.0" x="18368.992" y="1006.0"/> </glyph> <glyph class="state variable" id="_e89219f7-5733-41e1-be31-30596b5f3b41"> <state value="" variable="S350"/> <bbox w="30.0" h="10.0" x="18448.5" y="1006.2148"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s390_shh1_shh1_sa219"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 2 HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Glioma-associated oncogene family zinc finger PMID:18497536 PMID:17845852 PMID:11001584 References_end</body> </html> </notes> <label text="GLI2-185*"/> <bbox w="167.0" h="53.0" x="18298.75" y="1058.0"/> <glyph class="state variable" id="_eca740ef-bb88-47ec-9a14-5c472e5b515a"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18349.652" y="1053.0"/> </glyph> <glyph class="state variable" id="_f3ec0d65-0131-4348-a2ab-a9daef291b43"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18391.652" y="1053.0"/> </glyph> <glyph class="state variable" id="_8f69f494-57b9-44be-a279-38204f480380"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18398.36" y="1106.0"/> </glyph> <glyph class="state variable" id="_d9b65001-e9d2-4e2d-8c45-6741ad547275"> <state value="" variable="S801"/> <bbox w="30.0" h="10.0" x="18352.984" y="1053.0"/> </glyph> <glyph class="state variable" id="_c40f9302-f99b-4d33-b9a7-ce1af3389df5"> <state value="" variable="K757"/> <bbox w="30.0" h="10.0" x="18283.75" y="1069.4772"/> </glyph> <glyph class="state variable" id="_0a4f95cc-28cf-4b6c-b344-e95e93e72f20"> <state value="" variable="S956"/> <bbox w="30.0" h="10.0" x="18283.75" y="1105.6321"/> </glyph> <glyph class="state variable" id="_cd48637d-c18f-4079-9197-a1c4db8a7eff"> <state value="P" variable="S817"/> <bbox w="35.0" h="10.0" x="18446.959" y="1106.0"/> </glyph> <glyph class="state variable" id="_b7a359ee-ec70-4b25-81c0-7345c3462993"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18377.25" y="1053.0"/> </glyph> <glyph class="state variable" id="_6edca6a6-988c-4dfe-a141-24dccedb1556"> <state value="P" variable="S847"/> <bbox w="35.0" h="10.0" x="18333.092" y="1106.0"/> </glyph> <glyph class="state variable" id="_a894a2f8-57d6-47ca-9909-8b753761bc2d"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="18283.75" y="1079.4578"/> </glyph> <glyph class="state variable" id="_c5f572b7-479f-4846-b999-54b47db71a4e"> <state value="P" variable="S789"/> <bbox w="35.0" h="10.0" x="18281.25" y="1068.8666"/> </glyph> <glyph class="state variable" id="_28d262f8-59f6-414a-9c86-efb319cd880d"> <state value="" variable="S1011"/> <bbox w="35.0" h="10.0" x="18281.25" y="1088.8265"/> </glyph> <glyph class="state variable" id="_8095ceb3-7dea-4f28-a48a-1dd8bef7aca3"> <state value="P" variable="S805"/> <bbox w="35.0" h="10.0" x="18386.143" y="1053.0"/> </glyph> <glyph class="state variable" id="_a768b828-655c-48b7-b7d2-22733a863896"> <state value="" variable="S820"/> <bbox w="30.0" h="10.0" x="18413.695" y="1106.0"/> </glyph> <glyph class="state variable" id="_a70d366e-93f7-4aea-8bfb-76a75d893468"> <state value="" variable="S813"/> <bbox w="30.0" h="10.0" x="18450.75" y="1079.5844"/> </glyph> <glyph class="state variable" id="_45ff9279-c2f4-4c11-a208-d2fe5af6ccd3"> <state value="" variable="S850"/> <bbox w="30.0" h="10.0" x="18283.75" y="1104.6068"/> </glyph> <glyph class="state variable" id="_2bb091af-96b9-449c-8e8f-9d4db1e09d00"> <state value="" variable="S844"/> <bbox w="30.0" h="10.0" x="18362.033" y="1106.0"/> </glyph> <glyph class="state variable" id="_44594e55-4ecb-495f-ba38-85550c50fb8f"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="18284.777" y="1053.0"/> </glyph> <glyph class="state variable" id="_885b9f49-7fda-4a87-8fb8-dbb4afcb6591"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18398.36" y="1106.0"/> </glyph> <glyph class="state variable" id="_e2bc2f07-d8b3-4551-bbda-9ff84fafc908"> <state value="" variable="S808"/> <bbox w="30.0" h="10.0" x="18449.984" y="1053.0"/> </glyph> <glyph class="state variable" id="_1f455ec8-caa7-4095-a66d-822d8e252e70"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18338.021" y="1053.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s391_shh1_shh1_csa31" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GLI2-185*:SUFU:ULK3 Identifiers_end References_begin: s_shh1_re61:(MAP:survival) PMID:16611981 s_shh1_re64(MAP:survival): PMID:16611981 PMID:16651270 Gli2 ubi by bTrCP2 References_end</body> </html> </notes> <label text="Gli2-185_SUFU_ULK3"/> <bbox w="196.0" h="150.0" x="18564.5" y="983.0"/> <glyph class="macromolecule" id="shh1_shh1_s410_shh1_shh1_sa26"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 2 HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Glioma-associated oncogene family zinc finger PMID:18497536 PMID:17845852 PMID:11001584 References_end</body> </html> </notes> <label text="GLI2-185*"/> <bbox w="163.0" h="39.0" x="18582.0" y="1063.5"/> <glyph class="state variable" id="_0c771795-cf83-488f-a54c-a19a964b9fbb"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18631.564" y="1058.5"/> </glyph> <glyph class="state variable" id="_359dfb4c-b03a-49d6-9de6-e780d3b27dfd"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18672.557" y="1058.5"/> </glyph> <glyph class="state variable" id="_f45b972c-b794-4979-be71-c285124e8456"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18679.104" y="1097.5"/> </glyph> <glyph class="state variable" id="_8a1b1487-6ad3-4305-929d-35dbaeaa3d40"> <state value="P" variable="S801"/> <bbox w="35.0" h="10.0" x="18632.076" y="1058.5"/> </glyph> <glyph class="state variable" id="_464d6490-7308-4182-8e03-9d58dc398a91"> <state value="" variable="K757"/> <bbox w="30.0" h="10.0" x="18567.0" y="1070.6246"/> </glyph> <glyph class="state variable" id="_b1262be9-517b-4c26-9f76-2b1985d4fef1"> <state value="" variable="S956"/> <bbox w="30.0" h="10.0" x="18567.0" y="1097.2292"/> </glyph> <glyph class="state variable" id="_e1aca965-9ff8-434d-8839-95e1b0d2cc9b"> <state value="P" variable="S817"/> <bbox w="35.0" h="10.0" x="18726.24" y="1097.5"/> </glyph> <glyph class="state variable" id="_8713882f-9ec5-4c7a-bd97-f727b0c87dec"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18658.5" y="1058.5"/> </glyph> <glyph class="state variable" id="_d620ffe6-7e73-4ada-b1bd-7fc6367b5181"> <state value="P" variable="S847"/> <bbox w="35.0" h="10.0" x="18615.102" y="1097.5"/> </glyph> <glyph class="state variable" id="_94ff8689-ba15-4931-8f08-6fa3454b2dc3"> <state value="" variable="S385"/> <bbox w="30.0" h="10.0" x="18567.0" y="1077.969"/> </glyph> <glyph class="state variable" id="_b7249086-7039-4310-907b-2447b55dc553"> <state value="P" variable="S789"/> <bbox w="35.0" h="10.0" x="18564.5" y="1070.1754"/> </glyph> <glyph class="state variable" id="_926b62b6-9de1-4935-97fd-de9d8f07c54f"> <state value="" variable="S1011"/> <bbox w="35.0" h="10.0" x="18564.5" y="1084.8629"/> </glyph> <glyph class="state variable" id="_ceee7d67-bc0b-4596-b79a-da9f39ff1d17"> <state value="P" variable="S805"/> <bbox w="35.0" h="10.0" x="18666.879" y="1058.5"/> </glyph> <glyph class="state variable" id="_6f2bbf3d-b20e-4eee-9ed4-0c52093ddc99"> <state value="P" variable="S820"/> <bbox w="35.0" h="10.0" x="18691.332" y="1097.5"/> </glyph> <glyph class="state variable" id="_93e5bb0e-d879-4ae8-8ddb-b1b217935e04"> <state value="P" variable="S813"/> <bbox w="35.0" h="10.0" x="18727.5" y="1078.0621"/> </glyph> <glyph class="state variable" id="_8c49259c-eef5-46ba-9deb-287b17d8ba31"> <state value="P" variable="S850"/> <bbox w="35.0" h="10.0" x="18564.5" y="1096.4747"/> </glyph> <glyph class="state variable" id="_6d2cf16c-c55f-4d63-b936-0638fe597b5f"> <state value="P" variable="S844"/> <bbox w="35.0" h="10.0" x="18640.908" y="1097.5"/> </glyph> <glyph class="state variable" id="_52508b43-55db-4454-9213-4a83aef25bb6"> <state value="P" variable="S792"/> <bbox w="35.0" h="10.0" x="18565.504" y="1058.5"/> </glyph> <glyph class="state variable" id="_53770da9-f562-4033-97c1-aceda04f2c31"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="18676.604" y="1097.5"/> </glyph> <glyph class="state variable" id="_3f7b78e3-a47c-41d6-afcb-4ae29927b09f"> <state value="P" variable="S808"/> <bbox w="35.0" h="10.0" x="18726.754" y="1058.5"/> </glyph> <glyph class="state variable" id="_9b9e953b-4092-42a1-ad10-4bec65c66acf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18620.21" y="1058.5"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s392_shh1_shh1_sa220"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <bbox w="80.0" h="40.0" x="18576.75" y="1012.0"/> <glyph class="state variable" id="_c73d7df9-321f-4f33-8652-8e18070ef712"> <state value="" variable="K257"/> <bbox w="30.0" h="10.0" x="18562.242" y="1007.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s393_shh1_shh1_sa221"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Unc-51-like kinase 3 HUGO:ULK3 HGNC:19703 ENTREZ:25989 UNIPROT:Q6PHR2 GENECARDS:ULK3 ATLASONC:GC_ULK3 WIKI:ULK3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Unc-51-like kinase PMID:20643644 PMID:19878745 References_end</body> </html> </notes> <label text="ULK3"/> <bbox w="80.0" h="40.0" x="18665.25" y="1011.0"/> <glyph class="state variable" id="_de347cee-bc35-45ea-997e-aab5806fef4b"> <state value="" variable="S384"/> <bbox w="30.0" h="10.0" x="18729.63" y="1046.0"/> </glyph> <glyph class="state variable" id="_cfef96d6-39b3-486c-9d27-28856aa062d1"> <state value="" variable="S464"/> <bbox w="30.0" h="10.0" x="18650.25" y="1045.7223"/> </glyph> <glyph class="state variable" id="_4d132eb2-3e6c-4c0c-822a-f733fb29c360"> <state value="" variable="S300"/> <bbox w="30.0" h="10.0" x="18650.742" y="1006.0"/> </glyph> <glyph class="state variable" id="_9dd947a6-b772-47b6-9530-a248e4052fe8"> <state value="" variable="S350"/> <bbox w="30.0" h="10.0" x="18730.25" y="1006.2148"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s414_shh1_shh1_csa36" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GLI2-185*:SUFU:ULK3 Identifiers_end References_begin: s_shh1_re71(MAP:survival): PMID:18455992 PMID:16611981 References_end</body> </html> </notes> <label text="Gli2-185_SUFU_ULK3"/> <bbox w="193.0" h="148.0" x="18892.75" y="1933.0"/> <glyph class="macromolecule" id="shh1_shh1_s487_shh1_shh1_sa236"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Unc-51-like kinase 3 HUGO:ULK3 HGNC:19703 ENTREZ:25989 UNIPROT:Q6PHR2 GENECARDS:ULK3 ATLASONC:GC_ULK3 WIKI:ULK3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Unc-51-like kinase PMID:20643644 PMID:19878745 References_end</body> </html> </notes> <label text="ULK3"/> <bbox w="80.0" h="40.0" x="18994.5" y="1951.0"/> <glyph class="state variable" id="_212d2e08-6a88-4cb3-9adf-ad61ab91094e"> <state value="" variable="S384"/> <bbox w="30.0" h="10.0" x="19058.88" y="1986.0"/> </glyph> <glyph class="state variable" id="_f5e4555f-38a5-4f63-b003-b1cd9a150ba8"> <state value="" variable="S464"/> <bbox w="30.0" h="10.0" x="18979.5" y="1985.7223"/> </glyph> <glyph class="state variable" id="_26b8a73d-d693-4cc3-b6ef-7b75e9305a3c"> <state value="" variable="S300"/> <bbox w="30.0" h="10.0" x="18979.992" y="1946.0"/> </glyph> <glyph class="state variable" id="_9ced0f6c-1d84-4632-a30e-d9014148d15f"> <state value="" variable="S350"/> <bbox w="30.0" h="10.0" x="19059.5" y="1946.2147"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s486_shh1_shh1_sa237"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <bbox w="80.0" h="40.0" x="18904.0" y="1949.0"/> <glyph class="state variable" id="_9abb4e10-4015-405b-a6a6-1a0182fe7ab4"> <state value="" variable="K257"/> <bbox w="30.0" h="10.0" x="18889.492" y="1944.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s424_shh1_shh1_sa238"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 2 HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Glioma-associated oncogene family zinc finger PMID:18497536 PMID:17845852 PMID:11001584 References_end</body> </html> </notes> <label text="GLI2-185*"/> <bbox w="165.0" h="45.0" x="18906.5" y="2010.0"/> <glyph class="state variable" id="_b81c6953-447f-4eb4-a9ca-ae49eb3853b3"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18956.732" y="2005.0"/> </glyph> <glyph class="state variable" id="_9eeb2903-6202-4495-ba1b-40d239ee1faf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18998.229" y="2005.0"/> </glyph> <glyph class="state variable" id="_747d95bb-3785-4ff5-8df0-dbd2de407242"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19004.855" y="2050.0"/> </glyph> <glyph class="state variable" id="_b4e84f3a-bc5d-4fb1-8eae-36ee9f31fcc5"> <state value="P" variable="S801"/> <bbox w="35.0" h="10.0" x="18957.406" y="2005.0"/> </glyph> <glyph class="state variable" id="_0ff0be36-42b6-4a48-b314-2767730f58ed"> <state value="" variable="K757"/> <bbox w="30.0" h="10.0" x="18891.5" y="2018.99"/> </glyph> <glyph class="state variable" id="_1038d972-054f-4869-a0da-3099a6a89817"> <state value="" variable="S956"/> <bbox w="30.0" h="10.0" x="18891.5" y="2049.6875"/> </glyph> <glyph class="state variable" id="_d3f27b78-f7c5-40a6-b330-ae61a2ee6dea"> <state value="" variable="S817"/> <bbox w="30.0" h="10.0" x="19055.225" y="2050.0"/> </glyph> <glyph class="state variable" id="_38acd085-a990-47f3-8bd0-db5029077c7c"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18984.0" y="2005.0"/> </glyph> <glyph class="state variable" id="_dd2dbeab-0742-48bd-b07a-89a1781ef5fa"> <state value="" variable="S847"/> <bbox w="30.0" h="10.0" x="18942.72" y="2050.0"/> </glyph> <glyph class="state variable" id="_df1118fb-3fea-4890-a7fd-6c6a37d3f180"> <state value="P" variable="S385"/> <bbox w="35.0" h="10.0" x="18889.0" y="2027.4641"/> </glyph> <glyph class="state variable" id="_0ddfbfb2-044f-4c90-b771-f17fb746064b"> <state value="" variable="S789"/> <bbox w="30.0" h="10.0" x="18891.5" y="2018.4717"/> </glyph> <glyph class="state variable" id="_a50c4cbc-c903-4af6-b611-f86defa2bd2a"> <state value="P" variable="S1011"/> <bbox w="40.0" h="10.0" x="18886.5" y="2035.4188"/> </glyph> <glyph class="state variable" id="_2efcf2d3-6608-4e9b-b869-6742922932f6"> <state value="" variable="S805"/> <bbox w="30.0" h="10.0" x="18995.135" y="2005.0"/> </glyph> <glyph class="state variable" id="_1eb0b7b7-dbf1-49e4-9c63-e388fcb28254"> <state value="P" variable="S820"/> <bbox w="35.0" h="10.0" x="19017.389" y="2050.0"/> </glyph> <glyph class="state variable" id="_a489f7d5-bf7f-4243-95ff-25d1d93863f9"> <state value="P" variable="S813"/> <bbox w="35.0" h="10.0" x="19054.0" y="2027.5717"/> </glyph> <glyph class="state variable" id="_3d22793b-dcb7-47b1-82af-178ca15ac7d8"> <state value="P" variable="S850"/> <bbox w="35.0" h="10.0" x="18889.0" y="2048.8171"/> </glyph> <glyph class="state variable" id="_1a4d19b3-c6fd-4c19-8a3c-1e0582a5c3fe"> <state value="P" variable="S844"/> <bbox w="35.0" h="10.0" x="18966.346" y="2050.0"/> </glyph> <glyph class="state variable" id="_450067bc-a1cc-4a8c-9e61-30718359eb4f"> <state value="P" variable="S792"/> <bbox w="35.0" h="10.0" x="18890.016" y="2005.0"/> </glyph> <glyph class="state variable" id="_037bd5aa-023c-4731-83b4-df3b61abcf6a"> <state value="P" variable=""/> <bbox w="15.0" h="10.0" x="19002.355" y="2050.0"/> </glyph> <glyph class="state variable" id="_d92803f5-136a-4334-a675-3b52f82a15e5"> <state value="P" variable="S808"/> <bbox w="35.0" h="10.0" x="19053.244" y="2005.0"/> </glyph> <glyph class="state variable" id="_43f28a25-1bb9-4d15-a5c6-6b0239338c40"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18945.24" y="2005.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s405_shh1_shh1_csa35" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GLI2-185*:SUFU:ULK3 Identifiers_end References_begin: s_shh1_re70:(MAP:survival) PMID:18455992 s_shh1_re71(MAP:survival): PMID:18455992 PMID:16611981 References_end</body> </html> </notes> <label text="Gli2-185_SUFU_ULK3"/> <bbox w="193.0" h="148.0" x="18892.5" y="1714.0"/> <glyph class="macromolecule" id="shh1_shh1_s409_shh1_shh1_sa233"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 2 HUGO:GLI2 HGNC:4318 ENTREZ:2736 UNIPROT:P10070 GENECARDS:GLI2 KEGG:2736 ATLASONC:GC_GLI2 WIKI:GLI2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Glioma-associated oncogene family zinc finger PMID:18497536 PMID:17845852 PMID:11001584 References_end</body> </html> </notes> <label text="GLI2-185*"/> <bbox w="165.0" h="45.0" x="18906.25" y="1791.0"/> <glyph class="state variable" id="_499cf1cc-b907-4e8a-9bcd-a4a68a2f8a42"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18956.482" y="1786.0"/> </glyph> <glyph class="state variable" id="_c4f42994-a003-4962-9db1-7f86c291cc55"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18997.979" y="1786.0"/> </glyph> <glyph class="state variable" id="_59c4e93e-4c03-4321-ba14-0dd7504d3a58"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19004.605" y="1831.0"/> </glyph> <glyph class="state variable" id="_cccd5f1b-de22-4919-91fa-0e095afbf8bf"> <state value="" variable="S801"/> <bbox w="30.0" h="10.0" x="18959.656" y="1786.0"/> </glyph> <glyph class="state variable" id="_58093e39-e0db-4f71-803b-cabd4876cfbc"> <state value="" variable="K757"/> <bbox w="30.0" h="10.0" x="18891.25" y="1799.99"/> </glyph> <glyph class="state variable" id="_798bb055-02e8-4f81-9e65-221d1a1d336e"> <state value="" variable="S956"/> <bbox w="30.0" h="10.0" x="18891.25" y="1830.6876"/> </glyph> <glyph class="state variable" id="_77d0c60c-3d9a-4762-8430-1489869941be"> <state value="" variable="S817"/> <bbox w="30.0" h="10.0" x="19054.975" y="1831.0"/> </glyph> <glyph class="state variable" id="_5a48fb86-6ab5-421e-abdc-74a66aff5ef2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18983.75" y="1786.0"/> </glyph> <glyph class="state variable" id="_5d9b2e0f-a847-40a8-9212-84471ec9ac6c"> <state value="" variable="S847"/> <bbox w="30.0" h="10.0" x="18942.47" y="1831.0"/> </glyph> <glyph class="state variable" id="_4474617c-b7db-46ee-a2e0-629ef4c8261f"> <state value="P" variable="S385"/> <bbox w="35.0" h="10.0" x="18888.75" y="1808.4641"/> </glyph> <glyph class="state variable" id="_a5413ca0-aa7f-415f-92fe-b440e9ff28eb"> <state value="" variable="S789"/> <bbox w="30.0" h="10.0" x="18891.25" y="1799.4717"/> </glyph> <glyph class="state variable" id="_6f18610f-b31e-4971-b534-f99827e7af0b"> <state value="P" variable="S1011"/> <bbox w="40.0" h="10.0" x="18886.25" y="1816.4188"/> </glyph> <glyph class="state variable" id="_3393b283-f4d5-43a2-aae1-b508610aa392"> <state value="" variable="S805"/> <bbox w="30.0" h="10.0" x="18994.885" y="1786.0"/> </glyph> <glyph class="state variable" id="_2b691d4b-9779-4120-afb7-79ba3c11e2dd"> <state value="" variable="S820"/> <bbox w="30.0" h="10.0" x="19019.639" y="1831.0"/> </glyph> <glyph class="state variable" id="_68b36619-6613-4cb4-a6e9-968cf331bc75"> <state value="" variable="S813"/> <bbox w="30.0" h="10.0" x="19056.25" y="1808.5717"/> </glyph> <glyph class="state variable" id="_83aed323-0454-404b-8a85-49f1ab541847"> <state value="" variable="S850"/> <bbox w="30.0" h="10.0" x="18891.25" y="1829.817"/> </glyph> <glyph class="state variable" id="_75a5abb6-43f6-4c4f-8a38-492b42af0c27"> <state value="" variable="S844"/> <bbox w="30.0" h="10.0" x="18968.596" y="1831.0"/> </glyph> <glyph class="state variable" id="_6704ebd3-78cf-409a-ab2b-7cc529cf4412"> <state value="" variable="S792"/> <bbox w="30.0" h="10.0" x="18892.266" y="1786.0"/> </glyph> <glyph class="state variable" id="_7dcdd9bb-42b4-4687-b2c7-2ef897a75fe2"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19004.605" y="1831.0"/> </glyph> <glyph class="state variable" id="_32c8a652-1129-4735-821e-bbc7215515c0"> <state value="" variable="S808"/> <bbox w="30.0" h="10.0" x="19055.494" y="1786.0"/> </glyph> <glyph class="state variable" id="_07747bd8-4c5a-46a8-80c5-0d2cde2256a7"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18944.99" y="1786.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s406_shh1_shh1_sa234"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Unc-51-like kinase 3 HUGO:ULK3 HGNC:19703 ENTREZ:25989 UNIPROT:Q6PHR2 GENECARDS:ULK3 ATLASONC:GC_ULK3 WIKI:ULK3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Unc-51-like kinase PMID:20643644 PMID:19878745 References_end</body> </html> </notes> <label text="ULK3"/> <bbox w="80.0" h="40.0" x="18993.25" y="1740.0"/> <glyph class="state variable" id="_24e10352-2bbf-420c-a530-87a4a01992d3"> <state value="" variable="S384"/> <bbox w="30.0" h="10.0" x="19057.63" y="1775.0"/> </glyph> <glyph class="state variable" id="_f76f5482-68dd-413d-ac3c-12147c37ab8e"> <state value="" variable="S464"/> <bbox w="30.0" h="10.0" x="18978.25" y="1774.7223"/> </glyph> <glyph class="state variable" id="_cc4da540-15a8-4df7-a6b1-a643cb04bc50"> <state value="" variable="S300"/> <bbox w="30.0" h="10.0" x="18978.742" y="1735.0"/> </glyph> <glyph class="state variable" id="_a219e452-aa52-42b3-8d53-fe4331edc61d"> <state value="" variable="S350"/> <bbox w="30.0" h="10.0" x="19058.25" y="1735.2147"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s407_shh1_shh1_sa235"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <bbox w="80.0" h="40.0" x="18907.75" y="1740.0"/> <glyph class="state variable" id="_f64e3abb-3d4f-4b38-8faf-65419faa6011"> <state value="" variable="K257"/> <bbox w="30.0" h="10.0" x="18893.242" y="1735.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s635_shh1_shh1_csa15" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HH Ligand:PTCH* Identifiers_end References_begin: s_shh1_re27:(MAP:survival) PMID:17430994 References_end</body> </html> </notes> <label text="PTC_HH_ligand"/> <clone/> <bbox w="117.0" h="159.0" x="18677.5" y="93.5"/> <glyph class="macromolecule" id="shh1_s645_shh1_shh1_sa135"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Patched 1 HUGO:PTCH1 HGNC:9585 ENTREZ:5727 UNIPROT:Q13635 GENECARDS:PTCH1 REACTOME:62393 KEGG:5727 ATLASONC:PTCH100 WIKI:PTCH1 Patched 2 HUGO:PTCH2 HGNC:9586 ENTREZ:8643 UNIPROT:Q9Y6C5 GENECARDS:PTCH2 REACTOME:62395 KEGG:8643 ATLASONC:PTCH2ID41892ch1p34 WIKI:PTCH2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:10021362 PMID:17641202 References_end</body> </html> </notes> <label text="PTCH*"/> <clone/> <bbox w="78.0" h="114.0" x="18695.0" y="120.5"/> <glyph class="unit of information" id="_602f9dbb-3d0d-4d7e-87db-578d2e8abc5e"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="18711.5" y="115.5"/> </glyph> </glyph> <glyph class="simple chemical" id="shh1_s646_shh1_shh1_sa136"> <label text="HH Ligand"/> <clone/> <bbox w="70.0" h="25.0" x="18698.0" y="109.5"/> </glyph> </glyph> <glyph class="complex" id="shh1_s635_shh1_shh1_csa17" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:HH Ligand:PTCH* Identifiers_end References_begin: s_shh1_re27:(MAP:survival) PMID:17430994 References_end</body> </html> </notes> <label text="PTC_HH_ligand"/> <clone/> <bbox w="105.0" h="173.0" x="18255.875" y="93.5"/> <glyph class="macromolecule" id="shh1_s645_shh1_shh1_sa140"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Patched 1 HUGO:PTCH1 HGNC:9585 ENTREZ:5727 UNIPROT:Q13635 GENECARDS:PTCH1 REACTOME:62393 KEGG:5727 ATLASONC:PTCH100 WIKI:PTCH1 Patched 2 HUGO:PTCH2 HGNC:9586 ENTREZ:8643 UNIPROT:Q9Y6C5 GENECARDS:PTCH2 REACTOME:62395 KEGG:8643 ATLASONC:PTCH2ID41892ch1p34 WIKI:PTCH2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:10021362 PMID:17641202 References_end</body> </html> </notes> <label text="PTCH*"/> <clone/> <bbox w="78.0" h="114.0" x="18268.375" y="120.5"/> <glyph class="unit of information" id="_e4a12055-e1c6-488f-b48a-cf13ac92ef1e"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="18284.875" y="115.5"/> </glyph> </glyph> <glyph class="simple chemical" id="shh1_s646_shh1_shh1_sa141"> <label text="HH Ligand"/> <clone/> <bbox w="70.0" h="25.0" x="18271.375" y="109.5"/> </glyph> </glyph> <glyph class="complex" id="shh1_s665_shh1_shh1_csa25" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GLI3-190*:SUFU:ULK3 Identifiers_end</body> </html> </notes> <label text="GLI3-190_SUFU_ULK3"/> <bbox w="200.0" h="140.0" x="19559.0" y="1239.0"/> <glyph class="macromolecule" id="shh1_shh1_s369_shh1_shh1_sa201"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 3 HUGO:GLI3 HGNC:4319 ENTREZ:2737 UNIPROT:P10071 GENECARDS:GLI3 KEGG:2737 ATLASONC:GC_GLI3 WIKI:GLI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI3-190*"/> <bbox w="165.0" h="41.0" x="19580.75" y="1310.0"/> <glyph class="state variable" id="_5ca3d52a-0e84-45e6-83b0-789a93724877"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19607.76" y="1305.0"/> </glyph> <glyph class="state variable" id="_7d33abbc-d787-42aa-a506-c0a63e594daf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19627.271" y="1305.0"/> </glyph> <glyph class="state variable" id="_6f5f1737-8f33-477b-8b0f-e44f79a1628d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19640.734" y="1305.0"/> </glyph> <glyph class="state variable" id="_6beb0a31-038d-411a-81cc-af5ea9694781"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19679.105" y="1346.0"/> </glyph> <glyph class="state variable" id="_83a364b2-aa69-43ea-8a6a-0e84cf856cab"> <state value="" variable="S860"/> <bbox w="30.0" h="10.0" x="19665.902" y="1305.0"/> </glyph> <glyph class="state variable" id="_a49d3136-97d7-4b61-9fde-8a5a45f24aea"> <state value="" variable="S907"/> <bbox w="30.0" h="10.0" x="19613.137" y="1346.0"/> </glyph> <glyph class="state variable" id="_5dd19027-8a49-4425-beff-bea49f088b1d"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19607.76" y="1305.0"/> </glyph> <glyph class="state variable" id="_55afafe7-fd36-457b-bc73-e95ba7327673"> <state value="" variable="S873"/> <bbox w="30.0" h="10.0" x="19730.75" y="1325.5653"/> </glyph> <glyph class="state variable" id="_f092166a-2182-4c2a-8371-e7352cfbdfa4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19627.271" y="1305.0"/> </glyph> <glyph class="state variable" id="_d386035f-1545-4547-940e-cfc0940b0be3"> <state value="" variable="S849"/> <bbox w="30.0" h="10.0" x="19566.766" y="1305.0"/> </glyph> <glyph class="state variable" id="_2bafb7ec-e405-470d-8bc3-e548b188221b"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19640.734" y="1305.0"/> </glyph> <glyph class="state variable" id="_9cacbc42-623a-4682-87e8-99cc7adcca26"> <state value="" variable="S868"/> <bbox w="30.0" h="10.0" x="19723.701" y="1305.0"/> </glyph> <glyph class="state variable" id="_346acfeb-cd14-4275-859f-b4d0d41655ba"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19679.105" y="1346.0"/> </glyph> <glyph class="state variable" id="_2dfc6ab7-06d4-4a63-a60a-e1cc34e893fb"> <state value="" variable="S877"/> <bbox w="30.0" h="10.0" x="19729.475" y="1346.0"/> </glyph> <glyph class="state variable" id="_a3599d7a-06cb-48d8-a6d1-8cdd94a1054e"> <state value="" variable="S880"/> <bbox w="30.0" h="10.0" x="19686.85" y="1346.0"/> </glyph> <glyph class="state variable" id="_087e10d0-40e7-44b7-9e91-2aa6b79e5f16"> <state value="" variable="S903"/> <bbox w="30.0" h="10.0" x="19649.703" y="1346.0"/> </glyph> <glyph class="state variable" id="_d4a9dacf-7fea-4236-9361-4158584723ce"> <state value="" variable="S910"/> <bbox w="30.0" h="10.0" x="19566.244" y="1346.0"/> </glyph> <glyph class="state variable" id="_e9d9b0e1-6c70-4927-b474-3a99e401a38d"> <state value="" variable="S852"/> <bbox w="30.0" h="10.0" x="19646.666" y="1305.0"/> </glyph> <glyph class="state variable" id="_9201c2c5-908f-4a9f-8a65-3a665ae3fdc2"> <state value="" variable="S1006"/> <bbox w="35.0" h="10.0" x="19563.25" y="1320.0116"/> </glyph> <glyph class="state variable" id="_40d796bc-7547-4488-a027-b858daef37d8"> <state value="" variable="S865"/> <bbox w="30.0" h="10.0" x="19683.207" y="1305.0"/> </glyph> <glyph class="state variable" id="_08bc6eae-cda0-42de-8387-5d55233ca3e6"> <state value="" variable="S980"/> <bbox w="30.0" h="10.0" x="19565.75" y="1327.7311"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s666_shh1_shh1_sa202"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <bbox w="80.0" h="40.0" x="19573.25" y="1257.0"/> <glyph class="state variable" id="_9f31c30c-2edb-45e9-99df-a1df90153836"> <state value="" variable="K257"/> <bbox w="30.0" h="10.0" x="19558.742" y="1252.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s667_shh1_shh1_sa203"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Unc-51-like kinase 3 HUGO:ULK3 HGNC:19703 ENTREZ:25989 UNIPROT:Q6PHR2 GENECARDS:ULK3 ATLASONC:GC_ULK3 WIKI:ULK3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Unc-51-like kinase PMID:20643644 PMID:19878745 References_end</body> </html> </notes> <label text="ULK3"/> <bbox w="80.0" h="40.0" x="19666.75" y="1256.0"/> <glyph class="state variable" id="_944c9dab-464b-4263-bb97-8ba19c5e5d3e"> <state value="" variable="S384"/> <bbox w="30.0" h="10.0" x="19731.13" y="1291.0"/> </glyph> <glyph class="state variable" id="_6f927925-d3a6-4fde-a407-12c89357e403"> <state value="" variable="S464"/> <bbox w="30.0" h="10.0" x="19651.75" y="1290.7223"/> </glyph> <glyph class="state variable" id="_9c629b70-a23a-45b5-9238-9c9db511a7c4"> <state value="" variable="S300"/> <bbox w="30.0" h="10.0" x="19652.242" y="1251.0"/> </glyph> <glyph class="state variable" id="_f556424c-1651-4aac-a130-5858c7e6c33b"> <state value="" variable="S350"/> <bbox w="30.0" h="10.0" x="19731.75" y="1251.2147"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s372_shh1_shh1_csa26" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GLI3-190*:SUFU:ULK3 Identifiers_end References_begin: s_shh1_re56:(MAP:survival) PMID:16371461 References_end</body> </html> </notes> <label text="GLI3-190_SUFU_ULK3"/> <bbox w="200.0" h="140.0" x="19227.0" y="1239.0"/> <glyph class="macromolecule" id="shh1_shh1_s185_shh1_shh1_sa68"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 3 HUGO:GLI3 HGNC:4319 ENTREZ:2737 UNIPROT:P10071 GENECARDS:GLI3 KEGG:2737 ATLASONC:GC_GLI3 WIKI:GLI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI3-190*"/> <bbox w="165.0" h="41.0" x="19248.75" y="1309.0"/> <glyph class="state variable" id="_39a4b986-a302-4bb4-89ea-ddfad1bb36d4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19275.76" y="1304.0"/> </glyph> <glyph class="state variable" id="_81466985-96b3-4665-8090-ca5e09607217"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19295.271" y="1304.0"/> </glyph> <glyph class="state variable" id="_8ae5bd76-d93b-401c-ae21-0dba77bae525"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19308.734" y="1304.0"/> </glyph> <glyph class="state variable" id="_bda8b602-374a-4660-811f-4096c33b1a1f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19347.105" y="1345.0"/> </glyph> <glyph class="state variable" id="_27367754-54e9-4978-8a47-160ee470cbc9"> <state value="" variable="S860"/> <bbox w="30.0" h="10.0" x="19333.902" y="1304.0"/> </glyph> <glyph class="state variable" id="_eabff2b4-eb07-4094-814f-78495c02a921"> <state value="P" variable="S907"/> <bbox w="35.0" h="10.0" x="19278.637" y="1345.0"/> </glyph> <glyph class="state variable" id="_1309b717-1ca8-42fe-864f-881a614266bc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19275.76" y="1304.0"/> </glyph> <glyph class="state variable" id="_1507bdf8-19f8-4063-96b1-e725063ed704"> <state value="" variable="S873"/> <bbox w="30.0" h="10.0" x="19398.75" y="1324.5653"/> </glyph> <glyph class="state variable" id="_6b2ac1f7-fff9-41c0-b728-4687353292a6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19295.271" y="1304.0"/> </glyph> <glyph class="state variable" id="_09431667-0835-402e-8083-ca675b505fdd"> <state value="P" variable="S849"/> <bbox w="35.0" h="10.0" x="19232.266" y="1304.0"/> </glyph> <glyph class="state variable" id="_2fc42aa9-cf40-45fd-83cc-12cda924adab"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19308.734" y="1304.0"/> </glyph> <glyph class="state variable" id="_e1ff2918-e231-40f8-9d0b-6ac7aec4fe83"> <state value="" variable="S868"/> <bbox w="30.0" h="10.0" x="19391.701" y="1304.0"/> </glyph> <glyph class="state variable" id="_8ff13da9-1e34-4a7c-baff-5c170b39aaad"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19347.105" y="1345.0"/> </glyph> <glyph class="state variable" id="_e3468a95-a386-490b-8636-0beb31a0f491"> <state value="P" variable="S877"/> <bbox w="35.0" h="10.0" x="19394.975" y="1345.0"/> </glyph> <glyph class="state variable" id="_34d07d69-9944-499d-b19f-c12fb6c663bc"> <state value="" variable="S880"/> <bbox w="30.0" h="10.0" x="19354.85" y="1345.0"/> </glyph> <glyph class="state variable" id="_315e6d05-4b4b-4312-99e4-a72e1615427e"> <state value="" variable="S903"/> <bbox w="30.0" h="10.0" x="19317.703" y="1345.0"/> </glyph> <glyph class="state variable" id="_ed5e957f-71bd-4280-a0ed-323a52f0a38a"> <state value="" variable="S910"/> <bbox w="30.0" h="10.0" x="19234.244" y="1345.0"/> </glyph> <glyph class="state variable" id="_f91b9066-14f6-4e22-abed-453ccd7867a0"> <state value="" variable="S852"/> <bbox w="30.0" h="10.0" x="19314.666" y="1304.0"/> </glyph> <glyph class="state variable" id="_2ab37eea-04b6-49f1-984b-4da8659a4229"> <state value="P" variable="S1006"/> <bbox w="40.0" h="10.0" x="19228.75" y="1319.0116"/> </glyph> <glyph class="state variable" id="_57cf43e5-1dae-4a27-8117-01d118c41204"> <state value="P" variable="S865"/> <bbox w="35.0" h="10.0" x="19348.707" y="1304.0"/> </glyph> <glyph class="state variable" id="_e3a42c33-b58e-4e0d-8846-6ec947e7c9a0"> <state value="P" variable="S980"/> <bbox w="35.0" h="10.0" x="19231.25" y="1326.7311"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s373_shh1_shh1_sa204"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <bbox w="80.0" h="40.0" x="19247.25" y="1254.0"/> <glyph class="state variable" id="_da626e96-7b48-4a1a-b730-f5565ccc9b6a"> <state value="" variable="K257"/> <bbox w="30.0" h="10.0" x="19232.742" y="1249.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s374_shh1_shh1_sa205"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Unc-51-like kinase 3 HUGO:ULK3 HGNC:19703 ENTREZ:25989 UNIPROT:Q6PHR2 GENECARDS:ULK3 ATLASONC:GC_ULK3 WIKI:ULK3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Unc-51-like kinase PMID:20643644 PMID:19878745 References_end</body> </html> </notes> <label text="ULK3"/> <bbox w="80.0" h="40.0" x="19334.75" y="1253.0"/> <glyph class="state variable" id="_07ea9567-7d54-45d8-9d44-cff2602d837a"> <state value="" variable="S384"/> <bbox w="30.0" h="10.0" x="19399.13" y="1288.0"/> </glyph> <glyph class="state variable" id="_5eb33813-5aa8-4672-a933-267db3ec954b"> <state value="" variable="S464"/> <bbox w="30.0" h="10.0" x="19319.75" y="1287.7223"/> </glyph> <glyph class="state variable" id="_2f428c68-9a99-4c0e-9975-17b9e8dca94d"> <state value="" variable="S300"/> <bbox w="30.0" h="10.0" x="19320.242" y="1248.0"/> </glyph> <glyph class="state variable" id="_995d8205-427b-4c8f-a205-5b16b319abba"> <state value="" variable="S350"/> <bbox w="30.0" h="10.0" x="19399.75" y="1248.2147"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s_shh1_s375_shh1_shh1_csa27" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GLI3-190*:SUFU:ULK3 Identifiers_end References_begin: s_shh1_re56:(MAP:survival) PMID:16371461 s_shh1_re59(MAP:survival): PMID:16371461 PMID:16651270 Gli3 ubi by bTrCP1 PMID:18813803 References_end</body> </html> </notes> <label text="GLI3-190_SUFU_ULK3"/> <bbox w="200.0" h="140.0" x="18895.0" y="1239.0"/> <glyph class="macromolecule" id="shh1_shh1_s205_shh1_shh1_sa84"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Gli family zinc finger 3 HUGO:GLI3 HGNC:4319 ENTREZ:2737 UNIPROT:P10071 GENECARDS:GLI3 KEGG:2737 ATLASONC:GC_GLI3 WIKI:GLI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11001584 References_end</body> </html> </notes> <label text="GLI3-190*"/> <bbox w="165.0" h="41.0" x="18909.0" y="1304.0"/> <glyph class="state variable" id="_4d4dced9-65c6-4243-9fed-ca299ada9ac4"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18936.01" y="1299.0"/> </glyph> <glyph class="state variable" id="_6038692c-af0b-4dd5-bf14-fa3619e075bc"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18955.521" y="1299.0"/> </glyph> <glyph class="state variable" id="_fa90033d-31e1-469a-9f2f-4b36a66ba97f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18968.984" y="1299.0"/> </glyph> <glyph class="state variable" id="_fe6eb0d7-8c80-48e4-be9b-483c94217812"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19007.355" y="1340.0"/> </glyph> <glyph class="state variable" id="_9d16e365-2fac-4dae-a321-7e07b3f8759e"> <state value="P" variable="S860"/> <bbox w="35.0" h="10.0" x="18991.652" y="1299.0"/> </glyph> <glyph class="state variable" id="_d75cf10e-0ba8-45c1-9fb9-7b7092f16bcf"> <state value="P" variable="S907"/> <bbox w="35.0" h="10.0" x="18938.887" y="1340.0"/> </glyph> <glyph class="state variable" id="_57977d5b-b9f8-4f46-a91a-698cfcdbd9c6"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18936.01" y="1299.0"/> </glyph> <glyph class="state variable" id="_008c8e29-1584-4e01-bc4f-e598f2165a3e"> <state value="P" variable="S873"/> <bbox w="35.0" h="10.0" x="19056.5" y="1319.5653"/> </glyph> <glyph class="state variable" id="_c1ab5a01-0ca4-4c4b-816b-90f9c55344cf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18955.521" y="1299.0"/> </glyph> <glyph class="state variable" id="_189aa4e9-f924-4b6d-a1ed-87b70a8f8fad"> <state value="P" variable="S849"/> <bbox w="35.0" h="10.0" x="18892.516" y="1299.0"/> </glyph> <glyph class="state variable" id="_78f6d2a5-55c9-4ccb-b3e5-db14c25f0fae"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18968.984" y="1299.0"/> </glyph> <glyph class="state variable" id="_1f965660-bd7f-473a-8762-4f38e29936af"> <state value="P" variable="S868"/> <bbox w="35.0" h="10.0" x="19049.451" y="1299.0"/> </glyph> <glyph class="state variable" id="_0a1be87d-63d5-40b7-9f9f-cf28543b199f"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="19007.355" y="1340.0"/> </glyph> <glyph class="state variable" id="_04735f41-0c0d-4425-8bc8-4be7de916969"> <state value="P" variable="S877"/> <bbox w="35.0" h="10.0" x="19055.225" y="1340.0"/> </glyph> <glyph class="state variable" id="_f643b1ae-45fe-4cdb-8dfe-f2f22650b216"> <state value="P" variable="S880"/> <bbox w="35.0" h="10.0" x="19012.6" y="1340.0"/> </glyph> <glyph class="state variable" id="_7b14beac-4f7e-4a13-8fd9-fca497c75fee"> <state value="P" variable="S903"/> <bbox w="35.0" h="10.0" x="18975.453" y="1340.0"/> </glyph> <glyph class="state variable" id="_fd54d837-0fbd-4157-b6bd-d40b1858621b"> <state value="P" variable="S910"/> <bbox w="35.0" h="10.0" x="18891.994" y="1340.0"/> </glyph> <glyph class="state variable" id="_4c112017-7376-4842-9540-ae4a49de29d9"> <state value="P" variable="S852"/> <bbox w="35.0" h="10.0" x="18972.416" y="1299.0"/> </glyph> <glyph class="state variable" id="_60688290-5ccb-4342-a12c-9b3a6180af17"> <state value="P" variable="S1006"/> <bbox w="40.0" h="10.0" x="18889.0" y="1314.0116"/> </glyph> <glyph class="state variable" id="_a8d75771-368c-4a88-9d7e-6dfdef13df85"> <state value="P" variable="S865"/> <bbox w="35.0" h="10.0" x="19008.957" y="1299.0"/> </glyph> <glyph class="state variable" id="_67d24b82-4b67-4d3d-86f5-b140782073e4"> <state value="P" variable="S980"/> <bbox w="35.0" h="10.0" x="18891.5" y="1321.7311"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s376_shh1_shh1_sa206"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Sufu HUGO:SUFU HGNC:16466 ENTREZ:51684 UNIPROT:Q9UMX1 GENECARDS:SUFU KEGG:51684 ATLASONC:GC_SUFU WIKI:SUFU Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055941 PMID:19684112 References_end</body> </html> </notes> <label text="SUFU"/> <bbox w="80.0" h="40.0" x="18907.25" y="1254.0"/> <glyph class="state variable" id="_b7c69756-3c6f-4891-83e2-2e488f0c2236"> <state value="" variable="K257"/> <bbox w="30.0" h="10.0" x="18892.742" y="1249.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_shh1_s377_shh1_shh1_sa207"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Unc-51-like kinase 3 HUGO:ULK3 HGNC:19703 ENTREZ:25989 UNIPROT:Q6PHR2 GENECARDS:ULK3 ATLASONC:GC_ULK3 WIKI:ULK3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: Unc-51-like kinase PMID:20643644 PMID:19878745 References_end</body> </html> </notes> <label text="ULK3"/> <bbox w="80.0" h="40.0" x="18994.75" y="1252.0"/> <glyph class="state variable" id="_802a8aa5-9808-46c8-bdf4-705416ab8e7e"> <state value="" variable="S384"/> <bbox w="30.0" h="10.0" x="19059.13" y="1287.0"/> </glyph> <glyph class="state variable" id="_5e8eabff-6b21-49af-b5f7-6a94ac3022d7"> <state value="" variable="S464"/> <bbox w="30.0" h="10.0" x="18979.75" y="1286.7223"/> </glyph> <glyph class="state variable" id="_a41f44c1-e150-4fea-a0b8-809824b10a55"> <state value="" variable="S300"/> <bbox w="30.0" h="10.0" x="18980.242" y="1247.0"/> </glyph> <glyph class="state variable" id="_7ae8f300-df86-4147-a45d-919922079bf5"> <state value="" variable="S350"/> <bbox w="30.0" h="10.0" x="19059.75" y="1247.2147"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s668_shh1_shh1_csa47" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:AKT*:PI3,4,5-P3 Identifiers_end References_begin: s_shh1_re101:(MAP:survival) PMID:17688959 References_end</body> </html> </notes> <label text="(PIP3_AKT)"/> <bbox w="100.0" h="120.0" x="17988.0" y="124.0"/> <glyph class="simple chemical" id="shh1_s669_shh1_shh1_sa297"> <label text="PI3,4,5-P3"/> <bbox w="70.0" h="25.0" x="18000.0" y="137.5"/> </glyph> <glyph class="macromolecule" id="shh1_shh1_s523_shh1_shh1_sa298"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body> <html> <body>Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 Identifiers_end Maps_Modules_begin: MAP:mpk1 / MODULE:MAPK Maps_Modules_end Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 GENECARDS:AKT2 REACTOME:49860 KEGG:208 ATLASONC:AKT2ID517ch19q13 WIKI:AKT2 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:CDH2 HGNC:1759 ENTREZ:1000 UNIPROT:P19022 GENECARDS:CDH2 REACTOME:51212 KEGG:1000 ATLASONC:GC_CDH2 WIKI:CDH2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end</body> </html> Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 GENECARDS:AKT2 REACTOME:49860 KEGG:208 ATLASONC:AKT2ID517ch19q13 WIKI:AKT2 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:CDH2 HGNC:1759 ENTREZ:1000 UNIPROT:P19022 GENECARDS:CDH2 REACTOME:51212 KEGG:1000 ATLASONC:GC_CDH2 WIKI:CDH2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end</body> </html> Identifiers_begin: v-akt murine thymoma viral oncogene homolog 1 HUGO:AKT1 HGNC:391 ENTREZ:207 UNIPROT:P31749 GENECARDS:AKT1 REACTOME:58253 KEGG:207 ATLASONC:AKT1ID355ch14q32 WIKI:AKT1 v-akt murine thymoma viral oncogene homolog 2 HUGO:AKT2 HGNC:392 ENTREZ:208 UNIPROT:P31751 GENECARDS:AKT2 REACTOME:49860 KEGG:208 ATLASONC:AKT2ID517ch19q13 WIKI:AKT2 v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:AKT3 HGNC:393 ENTREZ:10000 UNIPROT:Q9Y243 GENECARDS:AKT3 REACTOME:415917 KEGG:10000 ATLASONC:AKT3ID615ch1q44 WIKI:AKT3 HUGO:CDH2 HGNC:1759 ENTREZ:1000 UNIPROT:P19022 GENECARDS:CDH2 REACTOME:51212 KEGG:1000 ATLASONC:GC_CDH2 WIKI:CDH2 Identifiers_end Maps_Modules_begin: MAP:apoptosis / MODULE:AKT_MTOR MAP:apoptosis / MODULE:CASPASES MAP:apoptosis / MODULE:MITOCH_METABOLISM MAP:apoptosis / MODULE:MOMP_REGULATION MAP:dnarepair / MODULE:G1_S_CHECKPOINT MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:MAPK MAP:survival / MODULE:PI3K_AKT_MTOR MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20214616 PMID:17680028 PMID:20398329 References_end</body> </html> </notes> <label text="AKT*"/> <bbox w="80.0" h="40.0" x="17998.0" y="176.0"/> <glyph class="state variable" id="_66b24cc5-59f8-4dc6-9c49-1c97d14454eb"> <state value="" variable="S129"/> <bbox w="30.0" h="10.0" x="17983.0" y="210.7223"/> </glyph> <glyph class="state variable" id="_34269fbc-6988-4bf0-8f51-c9720637710c"> <state value="" variable="T450"/> <bbox w="30.0" h="10.0" x="18063.0" y="171.21477"/> </glyph> <glyph class="state variable" id="_43388261-a583-4dad-8baa-4da018e4fbe7"> <state value="" variable="S473"/> <bbox w="30.0" h="10.0" x="18062.38" y="211.0"/> </glyph> <glyph class="state variable" id="_331350ce-72b3-4dec-bb8d-edab5519f813"> <state value="" variable="T308"/> <bbox w="30.0" h="10.0" x="17983.492" y="171.0"/> </glyph> <glyph class="state variable" id="_bfefbd66-615f-442a-b7c7-0d244ce6d1e9"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18073.0" y="171.0"/> </glyph> <glyph class="state variable" id="_e3a208a2-4374-4419-9d5d-d4d9cb2582b1"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="17993.0" y="191.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s670_shh1_shh2_csa21" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:CDK8:Core_promoter*:CyclinC*:MED12:MED13:Mediator* Identifiers_end References_begin: s_shh2_re51(MAP:survival): PMID:9216996 PMID:16413481 PMID:17000779 ANNOTATION: it was shown that Med12 binds to Gli1 promoter References_end</body> </html> </notes> <label text="MEDIATOR_MED_CYCLINC_CDK8"/> <bbox w="280.0" h="159.0" x="19251.0" y="3472.0"/> <glyph class="nucleic acid feature" id="shh1_s671_shh1_shh2_sa186"> <label text="Core_promoter*"/> <bbox w="70.0" h="25.0" x="19358.0" y="3583.5"/> </glyph> <glyph class="macromolecule" id="shh1_s672_shh1_shh2_sa187"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21330129 ANNOTATION: Mediator consists of more than 20 subunits and can also excists as an holoenzyme. Therefore Mediator is depicted as one simple protein to reduce complexity. References_end</body> </html> </notes> <label text="Mediator*"/> <bbox w="80.0" h="40.0" x="19262.0" y="3530.0"/> </glyph> <glyph class="macromolecule" id="shh1_s673_shh1_shh2_sa188"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Cyclin C HUGO:CCNC HGNC:1581 ENTREZ:892 UNIPROT:P24863 GENECARDS:CCNC REACTOME:51936 KEGG:892 ATLASONC:GC_CCNC WIKI:CCNC Identifiers_end Maps_Modules_begin: MAP:cellcycle / MODULE:CYCLINC MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21330129 References_end</body> </html> </notes> <label text="CyclinC*"/> <bbox w="80.0" h="40.0" x="19430.0" y="3530.0"/> </glyph> <glyph class="macromolecule" id="shh1_s674_shh1_shh2_sa189"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Cyclin-dependent kinase 8 HUGO:CDK8 HGNC:1779 ENTREZ:1024 UNIPROT:P49336 GENECARDS:CDK8 REACTOME:69456 KEGG:1024 ATLASONC:GC_CDK8 WIKI:CDK8 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21327159 PMID:21330129 Cyclin-dependent kinase References_end</body> </html> </notes> <label text="CDK8"/> <bbox w="80.0" h="40.0" x="19430.0" y="3485.0"/> </glyph> <glyph class="macromolecule" id="shh1_s675_shh1_shh2_sa190"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Mediator complex subunit 12 HUGO:MED12 HGNC:11957 ENTREZ:9968 UNIPROT:Q93074 GENECARDS:MED12 REACTOME:65526 KEGG:9968 ATLASONC:GC_MED12 WIKI:MED12 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17000779 PMID:21330129 Mediator complex subunit References_end</body> </html> </notes> <label text="MED12"/> <bbox w="80.0" h="40.0" x="19346.0" y="3485.0"/> </glyph> <glyph class="macromolecule" id="shh1_s676_shh1_shh2_sa191"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Mediator complex subunit 13 HUGO:MED13 HGNC:22474 ENTREZ:9969 UNIPROT:Q9UHV7 GENECARDS:MED13 REACTOME:65530 KEGG:9969 WIKI:MED13 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17000779 PMID:21330129 Mediator complex subunit References_end</body> </html> </notes> <label text="MED13"/> <bbox w="80.0" h="40.0" x="19346.0" y="3530.0"/> </glyph> </glyph> <glyph class="complex" id="shh1_s677_shh1_shh2_csa19" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MIR378:SUFU Identifiers_end References_begin: s_shh2_re160:(MAP:survival) PMID:18077375 References_end</body> </html> </notes> <label text="miR-378_SUFU"/> <clone/> <bbox w="100.0" h="120.0" x="19842.0" y="4036.0"/> <glyph class="nucleic acid feature" id="shh1_s678_shh1_shh2_sa181"> <label text="SUFU"/> <clone/> <bbox w="90.0" h="25.0" x="19847.25" y="4086.0"/> <glyph class="unit of information" id="_8cbf789a-9876-489b-b76f-fec05f275e65"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="19882.25" y="4081.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s679_shh1_shh2_sa182"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 378 HUGO:MIR378 GENECARDS:MIR378 KEGG:494327 WIKI:MIR378 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19446450 PMID:18077375 References_end</body> </html> </notes> <label text="MIR378"/> <clone/> <bbox w="90.0" h="25.0" x="19847.25" y="4053.0"/> <glyph class="unit of information" id="_ce0cc58c-4b3d-4bba-95eb-b19170c5efb1"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="19877.25" y="4048.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s677_shh1_shh2_csa42" compartmentRef="shh1_shh2_c2_shh1_shh2_ca2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:MIR378:SUFU Identifiers_end References_begin: s_shh2_re160:(MAP:survival) PMID:18077375 References_end</body> </html> </notes> <label text="miR-378_SUFU"/> <clone/> <bbox w="100.0" h="120.0" x="20114.0" y="4464.0"/> <glyph class="nucleic acid feature" id="shh1_s679_shh1_shh2_sa284"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: microRNA 378 HUGO:MIR378 GENECARDS:MIR378 KEGG:494327 WIKI:MIR378 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19446450 PMID:18077375 References_end</body> </html> </notes> <label text="MIR378"/> <clone/> <bbox w="90.0" h="25.0" x="20122.5" y="4474.0"/> <glyph class="unit of information" id="_2c151b30-574b-4502-ac5d-6b767a5b3bab"> <label text="asRNA"/> <bbox w="30.0" h="10.0" x="20152.5" y="4469.0"/> </glyph> </glyph> <glyph class="nucleic acid feature" id="shh1_s678_shh1_shh2_sa285"> <label text="SUFU"/> <clone/> <bbox w="90.0" h="25.0" x="20122.5" y="4505.0"/> <glyph class="unit of information" id="_1ec64db9-477f-4171-b7b8-f445ba86a6ef"> <label text="RNA"/> <bbox w="20.0" h="10.0" x="20157.5" y="4500.0"/> </glyph> </glyph> </glyph> <glyph class="complex" id="shh1_s680_shh1_shh3_csa2" compartmentRef="shh1_shh2_c1_shh1_shh3_ca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: NAME:GDP:G_alpha__sub_i_endsub_*:G_beta_*:G_gamma_*:HH Ligand:PTCH*:SMO Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: s_shh3_re2(MAP:survival): PMID:16885213 PMID:18815277 s_shh3_re5(MAP:survival): PMID:17430994 PMID:21474452 PMID:20081366 References_end</body> </html> </notes> <label text="Ptc_HH_ligand_Smo"/> <bbox w="340.0" h="179.0" x="18636.5" y="4919.0"/> <glyph class="macromolecule" id="shh1_s681_shh1_shh3_sa6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Patched 1 HUGO:PTCH1 HGNC:9585 ENTREZ:5727 UNIPROT:Q13635 GENECARDS:PTCH1 REACTOME:62393 KEGG:5727 ATLASONC:PTCH100 WIKI:PTCH1 Patched 2 HUGO:PTCH2 HGNC:9586 ENTREZ:8643 UNIPROT:Q9Y6C5 GENECARDS:PTCH2 REACTOME:62395 KEGG:8643 ATLASONC:PTCH2ID41892ch1p34 WIKI:PTCH2 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:10021362 PMID:17641202 References_end</body> </html> </notes> <label text="PTCH*"/> <bbox w="78.0" h="114.0" x="18888.0" y="4935.0"/> <glyph class="unit of information" id="_c5ca5fab-dc15-4a2e-abeb-f74f805ebd13"> <label text="receptor"/> <bbox w="45.0" h="10.0" x="18904.5" y="4930.0"/> </glyph> </glyph> <glyph class="simple chemical" id="shh1_shh3_s44_shh1_shh3_sa7"> <label text="HH Ligand"/> <bbox w="70.0" h="25.0" x="18891.0" y="4923.0"/> </glyph> <glyph class="macromolecule" id="shh1_s682_shh1_shh3_sa8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Smoothened HUGO:SMO HGNC:11119 ENTREZ:6608 UNIPROT:Q99835 GENECARDS:SMO REACTOME:64670 KEGG:6608 ATLASONC:GC_SMO WIKI:SMO Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18820483 PMID:17641202 Smoothened homologue (Drosophila) References_end</body> </html> </notes> <label text="SMO"/> <bbox w="80.0" h="40.0" x="18806.5" y="4964.0"/> <glyph class="state variable" id="_8662da6f-5125-4ee2-90c4-49106f434bbf"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18881.5" y="4959.0"/> </glyph> <glyph class="state variable" id="_a05985d2-862a-4b61-b605-09e2c7d28872"> <state value="" variable=""/> <bbox w="10.0" h="10.0" x="18881.5" y="4959.0"/> </glyph> </glyph> <glyph class="macromolecule" id="shh1_s683_shh1_shh3_sa24"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein) alpha inhibiting activity polypeptide 1 HUGO:GNAI1 HGNC:4384 ENTREZ:2770 UNIPROT:P63096 GENECARDS:GNAI1 REACTOME:55432 KEGG:2770 ATLASONC:GC_GNAI1 WIKI:GNAI1 Guanine nucleotide binding protein (G-protein) alpha inhibiting activity polypeptide 2 HUGO:GNAI2 HGNC:4385 ENTREZ:2771 UNIPROT:P04899 GENECARDS:GNAI2 REACTOME:55436 KEGG:2771 ATLASONC:GC_GNAI2 WIKI:GNAI2 Guanine nucleotide binding protein (G-protein) alpha inhibiting activity polypeptide 3 HUGO:GNAI3 HGNC:4387 ENTREZ:2773 UNIPROT:P08754 GENECARDS:GNAI3 REACTOME:55366 KEGG:2773 ATLASONC:GC_GNAI3 WIKI:GNAI3 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17430994 Guanine nucleotide binding protein (G-protein) References_end</body> </html> </notes> <label text="Gαi*"/> <bbox w="80.0" h="40.0" x="18645.5" y="5011.0"/> </glyph> <glyph class="macromolecule" id="shh1_s684_shh1_shh3_sa25"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), beta polypeptide 1 HUGO:GNB1 HGNC:4396 ENTREZ:2782 UNIPROT:P62873 GENECARDS:GNB1 REACTOME:55374 ATLASONC:GC_GNB1 WIKI:GNB1 Guanine nucleotide binding protein (G-protein), beta polypeptide 2 HUGO:GNB2 HGNC:4398 ENTREZ:2783 UNIPROT:P62879 GENECARDS:GNB2 REACTOME:55382 ATLASONC:GC_GNB2 WIKI:GNB2 Guanine nucleotide binding protein (G-protein), beta polypeptide 3 HUGO:GNB3 HGNC:4400 ENTREZ:2784 UNIPROT:P16520 GENECARDS:GNB3 REACTOME:55386 ATLASONC:GC_GNB3 WIKI:GNB3 Guanine nucleotide binding protein (G-protein), beta polypeptide 4 HUGO:GNB4 HGNC:20731 ENTREZ:59345 UNIPROT:Q9HAV0 GENECARDS:GNB4 REACTOME:55388 ATLASONC:GC_GNB4 WIKI:GNB4 Guanine nucleotide binding protein (G-protein), beta polypeptide 5 HUGOGNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 guanine nucleotide binding protein (G protein) beta 5 HUGO:GNB GENECARDS:GNB WIKI:GNB HUGO:GNB5 HGNC:4401 ENTREZ:10681 UNIPROT:O14775 GENECARDS:GNB5 REACTOME:401258 KEGG:10681 ATLASONC:GC_GNB5 WIKI:GNB5 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gβ*"/> <bbox w="80.0" h="40.0" x="18726.5" y="5010.0"/> </glyph> <glyph class="macromolecule" id="shh1_s685_shh1_shh3_sa26"> <notes> <html xmlns="http://www.sbml.org/sbml/level2/version4" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <body> <html> <body>Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> Identifiers_begin: Guanine nucleotide binding protein (G-protein), gamma 2 HUGO:GNG2 HGNC:4404 ENTREZ:54331 UNIPROT:P59768 GENECARDS:GNG2 REACTOME:91080 ATLASONC:GC_GNG2 WIKI:GNG2 Guanine nucleotide binding protein (G-protein), gamma 3 HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 Guanine nucleotide binding protein (G-protein), gamma 4 HUGO:GNG4 HGNC:4407 ENTREZ:2786 UNIPROT:P50150 GENECARDS:GNG4 REACTOME:55404 ATLASONC:GC_GNG4 WIKI:GNG4 Guanine nucleotide binding protein (G-protein), gamma 5 HUGO:GNG5 HGNC:4408 ENTREZ:2787 UNIPROT:P63218 GENECARDS:GNG5 REACTOME:55406 ATLASONC:GC_GNG5 WIKI:GNG5 Guanine nucleotide binding protein (G-protein), gamma 7 HUGO:GNG7 HGNC:4410 ENTREZ:2788 UNIPROT:O60262 GENECARDS:GNG7 REACTOME:55414 ATLASONC:GC_GNG7 WIKI:GNG7 Guanine nucleotide binding protein (G-protein), gamma 8 HUGO:GNG8 HGNC:19664 ENTREZ:94235 UNIPROT:Q9UK08 GENECARDS:GNG8 REACTOME:55416 KEGG:2793 ATLASONC:GC_GNG8 WIKI:GNG8 Guanine nucleotide binding protein (G-protein), gamma 10 HUGO:GNG10 HGNC:4402 ENTREZ:2790 UNIPROT:P50151 GENECARDS:GNG10 REACTOME:55418 ATLASONC:GC_GNG10 WIKI:GNG10 Guanine nucleotide binding protein (G-protein), gamma 11 HUGO:GNG11 HGNC:4403 ENTREZ:2791 UNIPROT:P61952 GENECARDS:GNG11 REACTOME:55420 KEGG:2791 ATLASONC:GC_GNG11 WIKI:GNG11 Guanine nucleotide binding protein (G-protein), gamma 12 HUGO:GNG12 HGNC:19663 ENTREZ:55970 UNIPROT:Q9UBI6 GENECARDS:GNG12 REACTOME:55426 ATLASONC:GC_GNG12 WIKI:GNG12 Guanine nucleotide binding protein (G-protein), gamma 13 HUGO:GNG13 GENECARDS:GNG13 KEGG:51764 ATLASONC:GC_GNG13 WIKI:GNG13 HUGO:GNG GENECARDS:GNG WIKI:GNG HUGO:GNG3 HGNC:4405 ENTREZ:2785 UNIPROT:P63215 GENECARDS:GNG3 REACTOME:55398 ATLASONC:GC_GNG3 WIKI:GNG3 guanine nucleotide binding protein (G protein) gamma transducing activity polypeptide 1 HUGO:GNGT1 HGNC:4411 ENTREZ:2792 UNIPROT:P63211 GENECARDS:GNGT1 REACTOME:55394 KEGG:2792 ATLASONC:GC_GNGT1 WIKI:GNGT1 guanine nucleotide binding protein (G protein) gamma 6 Identifiers_end Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG MAP:survival / MODULE:WNT_CANONICAL MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17430994 PMID:21640127 References_end</body> </html> </notes> <label text="Gγ*"/> <bbox w="80.0" h="40.0" x="18808.5" y="5010.0"/> </glyph> <glyph class="simple chemical" id="shh1_shh3_s105_shh1_shh3_sa74"> <label text="GDP"/> <bbox w="30.0" h="30.0" x="18671.5" y="5048.0"/> </glyph> </glyph> <glyph class="process" orientation="vertical" id="pr_b1547231-fce3-4274-9a58-fcbd5a2982d9"> <bbox w="10.0" h="10.0" x="286.53998" y="427.0"/> <port id="pr_b1547231-fce3-4274-9a58-fcbd5a2982d9_p1" x="291.53998" y="417.0"/> <port id="pr_b1547231-fce3-4274-9a58-fcbd5a2982d9_p2" x="291.53998" y="447.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c96f806b-0b5a-48d0-83ee-da3aeaaf3a0d"> <bbox w="10.0" h="10.0" x="1345.5" y="471.3672"/> <port id="pr_c96f806b-0b5a-48d0-83ee-da3aeaaf3a0d_p1" x="1365.5" y="476.3672"/> <port id="pr_c96f806b-0b5a-48d0-83ee-da3aeaaf3a0d_p2" x="1335.5" y="476.3672"/> </glyph> <glyph class="process" orientation="vertical" id="pr_aa12101a-91b1-4ab5-9b2a-2edcadbf88f6"> <bbox w="10.0" h="10.0" x="705.46875" y="435.0"/> <port id="pr_aa12101a-91b1-4ab5-9b2a-2edcadbf88f6_p1" x="710.46875" y="425.0"/> <port id="pr_aa12101a-91b1-4ab5-9b2a-2edcadbf88f6_p2" x="710.46875" y="455.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_334da06b-e046-4bfb-a931-0c0f3b98182f"> <bbox w="10.0" h="10.0" x="2492.7" y="464.5"/> <port id="pr_334da06b-e046-4bfb-a931-0c0f3b98182f_p1" x="2497.7" y="454.5"/> <port id="pr_334da06b-e046-4bfb-a931-0c0f3b98182f_p2" x="2497.7" y="484.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_cece030c-bb45-45eb-bd06-2736d974edb8"> <bbox w="10.0" h="10.0" x="778.0" y="737.5"/> <port id="pr_cece030c-bb45-45eb-bd06-2736d974edb8_p1" x="783.0" y="727.5"/> <port id="pr_cece030c-bb45-45eb-bd06-2736d974edb8_p2" x="783.0" y="757.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_68519b01-8fa3-43a4-bac7-c65700e52336"> <bbox w="10.0" h="10.0" x="1987.5" y="722.5"/> <port id="pr_68519b01-8fa3-43a4-bac7-c65700e52336_p1" x="1992.5" y="712.5"/> <port id="pr_68519b01-8fa3-43a4-bac7-c65700e52336_p2" x="1992.5" y="742.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_41379f93-b45d-4554-8e52-7e8808f45813"> <bbox w="10.0" h="10.0" x="1887.5" y="442.5"/> <port id="pr_41379f93-b45d-4554-8e52-7e8808f45813_p1" x="1892.5" y="432.5"/> <port id="pr_41379f93-b45d-4554-8e52-7e8808f45813_p2" x="1892.5" y="462.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_be3fce50-7311-437e-9483-95299fbfeb49"> <bbox w="10.0" h="10.0" x="2133.3572" y="479.5"/> <port id="pr_be3fce50-7311-437e-9483-95299fbfeb49_p1" x="2138.3572" y="469.5"/> <port id="pr_be3fce50-7311-437e-9483-95299fbfeb49_p2" x="2138.3572" y="499.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c0d7c666-ea67-4f8b-9423-8ecafc878428"> <bbox w="10.0" h="10.0" x="2207.5" y="648.9706"/> <port id="pr_c0d7c666-ea67-4f8b-9423-8ecafc878428_p1" x="2197.5" y="653.9706"/> <port id="pr_c0d7c666-ea67-4f8b-9423-8ecafc878428_p2" x="2227.5" y="653.9706"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b1955777-59f9-4e0a-897e-ea41d90511af"> <bbox w="10.0" h="10.0" x="3344.147" y="459.5"/> <port id="pr_b1955777-59f9-4e0a-897e-ea41d90511af_p1" x="3349.147" y="449.5"/> <port id="pr_b1955777-59f9-4e0a-897e-ea41d90511af_p2" x="3349.147" y="479.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_6560ab4c-f401-4a34-96cb-0edcbcf4cb72"> <bbox w="10.0" h="10.0" x="3537.74" y="417.0"/> <port id="pr_6560ab4c-f401-4a34-96cb-0edcbcf4cb72_p1" x="3542.74" y="407.0"/> <port id="pr_6560ab4c-f401-4a34-96cb-0edcbcf4cb72_p2" x="3542.74" y="437.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6df32f2b-0b17-45bd-b8bb-61efe590fae4"> <bbox w="10.0" h="10.0" x="542.5" y="879.375"/> <port id="pr_6df32f2b-0b17-45bd-b8bb-61efe590fae4_p1" x="532.5" y="884.375"/> <port id="pr_6df32f2b-0b17-45bd-b8bb-61efe590fae4_p2" x="562.5" y="884.375"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_347f49c5-b5db-425d-9b3f-5fab35c7c184"> <bbox w="10.0" h="10.0" x="760.625" y="833.125"/> <port id="pr_347f49c5-b5db-425d-9b3f-5fab35c7c184_p1" x="750.625" y="838.125"/> <port id="pr_347f49c5-b5db-425d-9b3f-5fab35c7c184_p2" x="780.625" y="838.125"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_492f258e-7a2a-4be9-a510-e950a396170a"> <bbox w="10.0" h="10.0" x="1058.75" y="890.0"/> <port id="pr_492f258e-7a2a-4be9-a510-e950a396170a_p1" x="1048.75" y="895.0"/> <port id="pr_492f258e-7a2a-4be9-a510-e950a396170a_p2" x="1078.75" y="895.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_4ee3945b-69b0-4f83-a76c-14c81ba9ede9"> <bbox w="10.0" h="10.0" x="1404.375" y="860.0"/> <port id="pr_4ee3945b-69b0-4f83-a76c-14c81ba9ede9_p1" x="1394.375" y="865.0"/> <port id="pr_4ee3945b-69b0-4f83-a76c-14c81ba9ede9_p2" x="1424.375" y="865.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_4dca2d5b-0f94-460e-be11-c524da7202e7"> <bbox w="10.0" h="10.0" x="964.0625" y="835.625"/> <port id="pr_4dca2d5b-0f94-460e-be11-c524da7202e7_p1" x="954.0625" y="840.625"/> <port id="pr_4dca2d5b-0f94-460e-be11-c524da7202e7_p2" x="984.0625" y="840.625"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d8dca37c-7dd2-4444-926f-7a0fefad9556"> <bbox w="10.0" h="10.0" x="1319.5625" y="979.0845"/> <port id="pr_d8dca37c-7dd2-4444-926f-7a0fefad9556_p1" x="1309.5625" y="984.0845"/> <port id="pr_d8dca37c-7dd2-4444-926f-7a0fefad9556_p2" x="1339.5625" y="984.0845"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2f43b005-35a7-4929-9030-451716d6a09e"> <bbox w="10.0" h="10.0" x="1659.875" y="951.0989"/> <port id="pr_2f43b005-35a7-4929-9030-451716d6a09e_p1" x="1649.875" y="956.0989"/> <port id="pr_2f43b005-35a7-4929-9030-451716d6a09e_p2" x="1679.875" y="956.0989"/> </glyph> <glyph class="process" orientation="vertical" id="pr_82fc905a-73f4-48c4-b6cd-08768493e51b"> <bbox w="10.0" h="10.0" x="747.5" y="881.875"/> <port id="pr_82fc905a-73f4-48c4-b6cd-08768493e51b_p1" x="752.5" y="871.875"/> <port id="pr_82fc905a-73f4-48c4-b6cd-08768493e51b_p2" x="752.5" y="901.875"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d253e464-76dd-43ba-a860-761585bac1cf"> <bbox w="10.0" h="10.0" x="1870.3125" y="862.1875"/> <port id="pr_d253e464-76dd-43ba-a860-761585bac1cf_p1" x="1860.3125" y="867.1875"/> <port id="pr_d253e464-76dd-43ba-a860-761585bac1cf_p2" x="1890.3125" y="867.1875"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_02ed535d-c65e-4982-bf70-4ee7783aca41"> <bbox w="10.0" h="10.0" x="1499.375" y="892.5"/> <port id="pr_02ed535d-c65e-4982-bf70-4ee7783aca41_p1" x="1489.375" y="897.5"/> <port id="pr_02ed535d-c65e-4982-bf70-4ee7783aca41_p2" x="1519.375" y="897.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_81d1aff0-08b8-4115-8ecb-351cbbb78ce2"> <bbox w="10.0" h="10.0" x="1409.375" y="846.25"/> <port id="pr_81d1aff0-08b8-4115-8ecb-351cbbb78ce2_p1" x="1414.375" y="836.25"/> <port id="pr_81d1aff0-08b8-4115-8ecb-351cbbb78ce2_p2" x="1414.375" y="866.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_2b232a6d-aa7a-4932-ba33-54b66b6beeb5"> <bbox w="10.0" h="10.0" x="1098.125" y="892.5"/> <port id="pr_2b232a6d-aa7a-4932-ba33-54b66b6beeb5_p1" x="1103.125" y="882.5"/> <port id="pr_2b232a6d-aa7a-4932-ba33-54b66b6beeb5_p2" x="1103.125" y="912.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_528791d5-dc5e-4de6-8dd4-ca93f614a857"> <bbox w="10.0" h="10.0" x="1889.375" y="966.875"/> <port id="pr_528791d5-dc5e-4de6-8dd4-ca93f614a857_p1" x="1894.375" y="956.875"/> <port id="pr_528791d5-dc5e-4de6-8dd4-ca93f614a857_p2" x="1894.375" y="986.875"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_68f57928-fcfb-49d6-9171-6c3a8ea60f72"> <bbox w="10.0" h="10.0" x="2270.9287" y="824.0625"/> <port id="pr_68f57928-fcfb-49d6-9171-6c3a8ea60f72_p1" x="2260.9287" y="829.0625"/> <port id="pr_68f57928-fcfb-49d6-9171-6c3a8ea60f72_p2" x="2290.9287" y="829.0625"/> </glyph> <glyph class="process" orientation="vertical" id="pr_6ceccc9d-dbec-40d3-9a21-6749fca77dab"> <bbox w="10.0" h="10.0" x="2707.5" y="454.5"/> <port id="pr_6ceccc9d-dbec-40d3-9a21-6749fca77dab_p1" x="2712.5" y="444.5"/> <port id="pr_6ceccc9d-dbec-40d3-9a21-6749fca77dab_p2" x="2712.5" y="474.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_24aeb168-eaff-4e39-8950-a59e997c04ff"> <bbox w="10.0" h="10.0" x="2430.625" y="886.875"/> <port id="pr_24aeb168-eaff-4e39-8950-a59e997c04ff_p1" x="2435.625" y="876.875"/> <port id="pr_24aeb168-eaff-4e39-8950-a59e997c04ff_p2" x="2435.625" y="906.875"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1671a113-be10-4e99-bc29-8196bb96e826"> <bbox w="10.0" h="10.0" x="2651.4062" y="856.5625"/> <port id="pr_1671a113-be10-4e99-bc29-8196bb96e826_p1" x="2656.4062" y="846.5625"/> <port id="pr_1671a113-be10-4e99-bc29-8196bb96e826_p2" x="2656.4062" y="876.5625"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_3912d9bf-8c85-4c0b-9b12-5336ed9c962d"> <bbox w="10.0" h="10.0" x="2030.3125" y="846.5625"/> <port id="pr_3912d9bf-8c85-4c0b-9b12-5336ed9c962d_p1" x="2050.3125" y="851.5625"/> <port id="pr_3912d9bf-8c85-4c0b-9b12-5336ed9c962d_p2" x="2020.3125" y="851.5625"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_dab8448d-0065-425f-99a0-d8963bf75ae7"> <bbox w="10.0" h="10.0" x="2185.9375" y="886.875"/> <port id="pr_dab8448d-0065-425f-99a0-d8963bf75ae7_p1" x="2205.9375" y="891.875"/> <port id="pr_dab8448d-0065-425f-99a0-d8963bf75ae7_p2" x="2175.9375" y="891.875"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_29983cdf-c514-4b8c-8020-e87e0fd2e97b"> <bbox w="10.0" h="10.0" x="1738.125" y="886.875"/> <port id="pr_29983cdf-c514-4b8c-8020-e87e0fd2e97b_p1" x="1758.125" y="891.875"/> <port id="pr_29983cdf-c514-4b8c-8020-e87e0fd2e97b_p2" x="1728.125" y="891.875"/> </glyph> <glyph class="process" orientation="vertical" id="pr_873036bc-b838-4dbe-a89d-09dd96abc8ad"> <bbox w="10.0" h="10.0" x="2533.9062" y="856.5625"/> <port id="pr_873036bc-b838-4dbe-a89d-09dd96abc8ad_p1" x="2538.9062" y="846.5625"/> <port id="pr_873036bc-b838-4dbe-a89d-09dd96abc8ad_p2" x="2538.9062" y="876.5625"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ba11f720-ce63-4120-b662-be3526070477"> <bbox w="10.0" h="10.0" x="3091.9" y="464.5"/> <port id="pr_ba11f720-ce63-4120-b662-be3526070477_p1" x="3096.9" y="454.5"/> <port id="pr_ba11f720-ce63-4120-b662-be3526070477_p2" x="3096.9" y="484.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ab72fbee-303d-4bb9-aa50-e206e322c00f"> <bbox w="10.0" h="10.0" x="2628.125" y="886.875"/> <port id="pr_ab72fbee-303d-4bb9-aa50-e206e322c00f_p1" x="2648.125" y="891.875"/> <port id="pr_ab72fbee-303d-4bb9-aa50-e206e322c00f_p2" x="2618.125" y="891.875"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_4415261d-c985-4559-b463-bbdc2ebee03c"> <bbox w="10.0" h="10.0" x="2581.25" y="855.0"/> <port id="pr_4415261d-c985-4559-b463-bbdc2ebee03c_p1" x="2601.25" y="860.0"/> <port id="pr_4415261d-c985-4559-b463-bbdc2ebee03c_p2" x="2571.25" y="860.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_79e0b68d-fee6-4901-b6fa-de865faaaa09"> <bbox w="10.0" h="10.0" x="2883.125" y="889.375"/> <port id="pr_79e0b68d-fee6-4901-b6fa-de865faaaa09_p1" x="2903.125" y="894.375"/> <port id="pr_79e0b68d-fee6-4901-b6fa-de865faaaa09_p2" x="2873.125" y="894.375"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_fa249708-c916-42d3-8636-61f64a8fb9d1"> <bbox w="10.0" h="10.0" x="2745.625" y="886.875"/> <port id="pr_fa249708-c916-42d3-8636-61f64a8fb9d1_p1" x="2765.625" y="891.875"/> <port id="pr_fa249708-c916-42d3-8636-61f64a8fb9d1_p2" x="2735.625" y="891.875"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_78d1e500-892f-4aa7-8267-dc83372c2fed"> <bbox w="10.0" h="10.0" x="2456.25" y="852.5"/> <port id="pr_78d1e500-892f-4aa7-8267-dc83372c2fed_p1" x="2476.25" y="857.5"/> <port id="pr_78d1e500-892f-4aa7-8267-dc83372c2fed_p2" x="2446.25" y="857.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_bdcb1a48-bc9b-417f-adf9-2d5784874270"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Sos mediates Ras activation. Interaction of Sos with Ras induces the formation of RasGTP from RasGDP. Spry is induced by activated ERK through phosphorylation on Tyr55. It positively regulates EGFR signalling by sequestering Cbl whereas it negatively regulates FGFR signalling by sequestering Grb2 from FSR2. PMID:17496910 PMID:15173823 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="925.92725" y="1623.8438"/> <port id="pr_bdcb1a48-bc9b-417f-adf9-2d5784874270_p1" x="930.92725" y="1613.8438"/> <port id="pr_bdcb1a48-bc9b-417f-adf9-2d5784874270_p2" x="930.92725" y="1643.8438"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b6807c24-861f-468b-9c0c-d9cfac0f7bee"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: B-Raf is recruited on the plasma membrane by activated Ras. Activated Ras functions as an adapter that binds to Raf kinases with high a???nity and causes their translocation to the cell membrane where Raf activation takes place. RasGTP and Sur-8 allow dephosphorylation of N-ter 14-3-3 binding site of Raf (not modelled) and thus its recruitment. PMID:19541618 PMID:11023813 PMID:17496910 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1340.5" y="1546.0"/> <port id="pr_b6807c24-861f-468b-9c0c-d9cfac0f7bee_p1" x="1345.5" y="1566.0"/> <port id="pr_b6807c24-861f-468b-9c0c-d9cfac0f7bee_p2" x="1345.5" y="1536.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_4ac6d449-7ee7-4e41-80e8-2e854cfbaf5f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: After having translocated to the plasma membrane KSR1 is able to interact with activated B-Raf and ERK. PMID:17496910 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1765.0" y="1484.026"/> <port id="pr_4ac6d449-7ee7-4e41-80e8-2e854cfbaf5f_p1" x="1755.0" y="1489.026"/> <port id="pr_4ac6d449-7ee7-4e41-80e8-2e854cfbaf5f_p2" x="1785.0" y="1489.026"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ac505458-d7a8-4426-b175-dbd0bee9c4e0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: ERK recruitment is enhanced by KSR1. ERK is then phosphorylated by MEK. PMID:19541618 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1736.25" y="1636.1288"/> <port id="pr_ac505458-d7a8-4426-b175-dbd0bee9c4e0_p1" x="1756.25" y="1641.1288"/> <port id="pr_ac505458-d7a8-4426-b175-dbd0bee9c4e0_p2" x="1726.25" y="1641.1288"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_fa588ae4-b141-43bd-83d5-af97ce8c7036"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MP1 is localised on late endosomes by P14. PMID:17178906 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1302.0387" y="2221.0166"/> <port id="pr_fa588ae4-b141-43bd-83d5-af97ce8c7036_p1" x="1322.0387" y="2226.0166"/> <port id="pr_fa588ae4-b141-43bd-83d5-af97ce8c7036_p2" x="1292.0387" y="2226.0166"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_7c3ef998-77b6-4479-93c1-d204ceb7458c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Formation of P14/MP1/MEK1 complex is required to activate the ERK cascade (and other processes) on late endosomes. PMID:17178906 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1436.8447" y="2413.8438"/> <port id="pr_7c3ef998-77b6-4479-93c1-d204ceb7458c_p1" x="1456.8447" y="2418.8438"/> <port id="pr_7c3ef998-77b6-4479-93c1-d204ceb7458c_p2" x="1426.8447" y="2418.8438"/> </glyph> <glyph class="process" orientation="vertical" id="pr_8a6dd9ae-e5f9-4f7a-b0ba-d324ac90879e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Transfer of activated RTK/Grb2/Sos/RasGTP complex to late endosomes where it binds P14/MP1/MEK1 complex allowing the ERK cascade. Upon EGF stimulation EGFR in complex with Grb2 is endocytosed and transported to late endosomes with Grb2-binding proteins such as Sos resulting in the activation of KRas on late endosomes. PMID:17496910 PMID:19289794 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1141.0823" y="2203.3281"/> <port id="pr_8a6dd9ae-e5f9-4f7a-b0ba-d324ac90879e_p1" x="1146.0823" y="2193.3281"/> <port id="pr_8a6dd9ae-e5f9-4f7a-b0ba-d324ac90879e_p2" x="1146.0823" y="2223.3281"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9b587785-9ed7-493f-a9b7-ecb740f8ceb6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Active KRas (on late endosomes) recruits Raf1 (C-Raf) to elicit a MODULE:MAPK signalling pathway. RasGTP and Sur-8 allow dephosphorylation of N-ter 14-3-3 binding site of Raf (not modelled) and thus its recruitment. PMID:19289794 PMID:17496910 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="983.75745" y="2467.4214"/> <port id="pr_9b587785-9ed7-493f-a9b7-ecb740f8ceb6_p1" x="973.75745" y="2472.4214"/> <port id="pr_9b587785-9ed7-493f-a9b7-ecb740f8ceb6_p2" x="1003.75745" y="2472.4214"/> </glyph> <glyph class="process" orientation="vertical" id="pr_8b98083f-4ef3-4059-bd53-a6671244da68"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Recruitment and phosphorylation of ERK1 on late endosomes. PMID:17496910 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1391.5854" y="2707.5"/> <port id="pr_8b98083f-4ef3-4059-bd53-a6671244da68_p1" x="1396.5854" y="2727.5"/> <port id="pr_8b98083f-4ef3-4059-bd53-a6671244da68_p2" x="1396.5854" y="2697.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1067b7c3-4b1b-421c-98af-3ba4cfdce0d9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Grb2 is recruited to the plasma membrane by activated RTKs. Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity. FGF stimulation leads to phosphorylation of Shp2 on a tyrosine residue that forms a complex with an additional molecule of Grb2. Grb2/Sos complexes are thus recruited directly and indirectly via Shp2 upon tyrosine phosphorylation of FRS2a in response to growth factor stimulation. PKC may cause phosphorylation of EGFR leading to a decrease in its activity. PMID:17496910 PMID:15567848 PMID:11447289 PMID:6321473 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="738.2683" y="1558.25"/> <port id="pr_1067b7c3-4b1b-421c-98af-3ba4cfdce0d9_p1" x="743.2683" y="1578.25"/> <port id="pr_1067b7c3-4b1b-421c-98af-3ba4cfdce0d9_p2" x="743.2683" y="1548.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_63012166-6a56-4e61-8b41-a0aa5fb29fb0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Docking of activated ERK to the KSR1 scaffold negatively regulates the interaction between KSR1 and B-Raf. PMID:19541618 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1707.75" y="1718.1049"/> <port id="pr_63012166-6a56-4e61-8b41-a0aa5fb29fb0_p1" x="1697.75" y="1723.1049"/> <port id="pr_63012166-6a56-4e61-8b41-a0aa5fb29fb0_p2" x="1727.75" y="1723.1049"/> </glyph> <glyph class="process" orientation="vertical" id="pr_35bc06f0-6fdd-49de-891a-a2522ee2eeb9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: KSR1 is cleaved by CASPASE3 in two regions: the C-ter region which mediates MEK binding and the N-ter region which contains the ERK binding site and the C1 domain required for plasma membrane localisation PMID:17613518 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2114.4773" y="1558.9858"/> <port id="pr_35bc06f0-6fdd-49de-891a-a2522ee2eeb9_p1" x="2119.4773" y="1548.9858"/> <port id="pr_35bc06f0-6fdd-49de-891a-a2522ee2eeb9_p2" x="2119.4773" y="1578.9858"/> </glyph> <glyph class="process" orientation="vertical" id="pr_2a4d9abf-8f77-4f7f-896c-e734fe918d1b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Caspase9 is phosphorylated on Thr125 in a MEK1/2-dependent manner in vivo. Furthermore caspase9 is efficiently phosphorylated on Thr125 by ERK in vitro suggesting that it is targeted directly by ERK in vivo. This is one of the ways ERK plays its anti-apoptotic role. PMID:12792650 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1728.25" y="2375.0"/> <port id="pr_2a4d9abf-8f77-4f7f-896c-e734fe918d1b_p1" x="1733.25" y="2395.0"/> <port id="pr_2a4d9abf-8f77-4f7f-896c-e734fe918d1b_p2" x="1733.25" y="2365.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_8d239b12-39cc-4f5c-a3b6-391d7f887496"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Activated caspase-9 cleaves and activates caspase-3 leading to apoptosis. PMID:9390557 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1928.5" y="2329.0"/> <port id="pr_8d239b12-39cc-4f5c-a3b6-391d7f887496_p1" x="1933.5" y="2349.0"/> <port id="pr_8d239b12-39cc-4f5c-a3b6-391d7f887496_p2" x="1933.5" y="2319.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9611edec-06da-491e-bc2a-414a49e5642a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: RasGTP interacts with IMP cleaving it from KSR1. In this way KSR1 can play its role of scaffolding protein for ERK cascade. Ras activation causes the cleavage of 14-3-3 from KSR1 (not modelled) exposing the membrane-targeting C1 domain as well as the docking site for ERK1/2. PMID:14724641 PMID:17496910 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2056.3762" y="1982.5913"/> <port id="pr_9611edec-06da-491e-bc2a-414a49e5642a_p1" x="2076.3762" y="1987.5913"/> <port id="pr_9611edec-06da-491e-bc2a-414a49e5642a_p2" x="2046.3762" y="1987.5913"/> </glyph> <glyph class="process" orientation="vertical" id="pr_62ff45a0-f2e2-42de-9065-ae979a847099"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Activation of ERK pathway caused the dissociation of the MP1/ERK1 complex. MP1 constitutively binds MEK1 but releases ERK/MODULE:MAPK after activation. This turnover could provide an amplification mechanism that translates low MEK activity into sustained ERK/MODULE:MAPK activation in which MP1 continues to supply MEK1 with inactive ERK/MODULE:MAPK for phosphorylation. PMID:15547943 PMID:16227978 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1309.6228" y="2711.5283"/> <port id="pr_62ff45a0-f2e2-42de-9065-ae979a847099_p1" x="1314.6228" y="2701.5283"/> <port id="pr_62ff45a0-f2e2-42de-9065-ae979a847099_p2" x="1314.6228" y="2731.5283"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_0301db84-5896-442f-9a5e-09176a4f3b15"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: In addition to Grb2/SOS PLCG and SRC are also recruited to activated PTKRs at the PM. Activation of the TCR results in tyrosine phosphorylation of the ?? chain of the receptor by Src family kinases and the resulting phosphotyrosines serve to recruit ZAP-70 (not modelled) that in turn phosphorylates the scaffold protein LAT (not modelled) at multiple sites. Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity. PMID:19615955 PMID:16488589 PMID:15567848 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="159.0" y="1390.0139"/> <port id="pr_0301db84-5896-442f-9a5e-09176a4f3b15_p1" x="149.0" y="1395.0139"/> <port id="pr_0301db84-5896-442f-9a5e-09176a4f3b15_p2" x="179.0" y="1395.0139"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f95c985a-30fb-4ed4-8e47-2746a7c511f3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Among the signalling molecules recruited to phosphorylated LAT is PLCG. Shp-2 (not modelled) contributes to Ras signalling from the Golgi by stimulating the activation of Src family of kinases and in turn their substrate PLCG. PMID:16488589 PMID:17496910 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="174.0" y="1572.5"/> <port id="pr_f95c985a-30fb-4ed4-8e47-2746a7c511f3_p1" x="164.0" y="1577.5"/> <port id="pr_f95c985a-30fb-4ed4-8e47-2746a7c511f3_p2" x="194.0" y="1577.5"/> </glyph> <glyph class="uncertain process" orientation="horizontal" id="pr_dcea8094-ebf0-47b9-a11d-d941f02479be"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: IP3 diffuses through the cytosol and binds to receptors on the endoplasmic reticulum causing the release of calcium ions (Ca2+) into the cytosol. http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Second_messengers.html References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="309.55096" y="1967.7495"/> <port id="pr_dcea8094-ebf0-47b9-a11d-d941f02479be_p1" x="299.55096" y="1972.7495"/> <port id="pr_dcea8094-ebf0-47b9-a11d-d941f02479be_p2" x="329.55096" y="1972.7495"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f2efd951-dc0c-406e-893f-4ec816de8262"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PLCG acts on PIP2 in the PM to produce DAG and IP3. PMID:16488589 IP3 diffuses through the cytosol and binds to receptors on the endoplasmic reticulum causing the release of calcium ions (Ca2+) into the cytosol. http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Second_messengers.html References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="317.5" y="1721.7617"/> <port id="pr_f2efd951-dc0c-406e-893f-4ec816de8262_p1" x="307.5" y="1726.7617"/> <port id="pr_f2efd951-dc0c-406e-893f-4ec816de8262_p2" x="337.5" y="1726.7617"/> </glyph> <glyph class="process" orientation="vertical" id="pr_f5ab3ffa-770b-4333-b517-5a8eb2bd99c9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: RasGRP1 is a C1-domain containing protein that is activated by DAG and Ca2+ in a manner analogous to members of the PKC family. PMID:17496910 DAG remains in the inner layer of the plasma membrane. It recruits Protein Kinase C (PKC) ??? a calcium-dependent kinase that phosphorylates many other proteins that bring about the changes in the cell. http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Second_messengers.html References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="400.55585" y="1583.0"/> <port id="pr_f5ab3ffa-770b-4333-b517-5a8eb2bd99c9_p1" x="405.55585" y="1603.0"/> <port id="pr_f5ab3ffa-770b-4333-b517-5a8eb2bd99c9_p2" x="405.55585" y="1573.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1fc8c650-7d20-4bbd-9ee4-684a8c49be17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Calcium liberated from internal stores by IP3 acts on the calcium- and DAG-sensitive RasGRP1 and causes it to translocate to the Golgi. PMID:16488589 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="477.45612" y="1621.4248"/> <port id="pr_1fc8c650-7d20-4bbd-9ee4-684a8c49be17_p1" x="482.45612" y="1641.4248"/> <port id="pr_1fc8c650-7d20-4bbd-9ee4-684a8c49be17_p2" x="482.45612" y="1611.4248"/> </glyph> <glyph class="process" orientation="vertical" id="pr_675b73d8-9937-474f-b9b0-c631c83426bc"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Calcium liberated from internal stores by IP3 acts on the calcium- and DAG-sensitive RasGRP1 and causes it to translocate to the Golgi. PMID:16488589 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="488.0" y="1858.75"/> <port id="pr_675b73d8-9937-474f-b9b0-c631c83426bc_p1" x="493.0" y="1848.75"/> <port id="pr_675b73d8-9937-474f-b9b0-c631c83426bc_p2" x="493.0" y="1878.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_cac1927c-b71d-4c07-a4a9-ccef29691b8d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Calcium activates the Ras GAP CAPRI (RASA4) that translocates to the PM and downregulates any Ras that is activated on this compartment by the exchange factor SOS. PMID:16488589 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="545.0" y="1825.0"/> <port id="pr_cac1927c-b71d-4c07-a4a9-ccef29691b8d_p1" x="550.0" y="1845.0"/> <port id="pr_cac1927c-b71d-4c07-a4a9-ccef29691b8d_p2" x="550.0" y="1815.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9166f41f-4373-4820-ba02-77d878373af6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: RasGTP and Sur-8 allow dephosphorylation of N-ter 14-3-3 binding site of Raf and thus its recruitment. PMID:17496910 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="362.25" y="2460.642"/> <port id="pr_9166f41f-4373-4820-ba02-77d878373af6_p1" x="382.25" y="2465.642"/> <port id="pr_9166f41f-4373-4820-ba02-77d878373af6_p2" x="352.25" y="2465.642"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_35a53ddf-9cda-4049-a0e0-6c163e0c5783"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Sef1 which is a putative transmembrane protein of the Golgi apparatus seems to be a scaffold protein that recruits ERK1/2 and MEK1/2 to its vicinity and probably allows their activation by Golgi-localised Ras proteins. PMID:19565474 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="532.5" y="2391.0063"/> <port id="pr_35a53ddf-9cda-4049-a0e0-6c163e0c5783_p1" x="552.5" y="2396.0063"/> <port id="pr_35a53ddf-9cda-4049-a0e0-6c163e0c5783_p2" x="522.5" y="2396.0063"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5994abe0-7c17-4d1b-9599-5947c837a1a4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Sef1 which is a putative transmembrane protein of the Golgi apparatus seems to be a scaffold protein that recruits ERK1/2 and MEK1/2 to its vicinity and probably allows their activation by Golgi-localised Ras proteins. PMID:19565474 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="602.0" y="2496.5"/> <port id="pr_5994abe0-7c17-4d1b-9599-5947c837a1a4_p1" x="592.0" y="2501.5"/> <port id="pr_5994abe0-7c17-4d1b-9599-5947c837a1a4_p2" x="622.0" y="2501.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_bdddd665-fb97-4c90-9556-936a2acea9ca"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN. PMID:11226259 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2207.0" y="1633.8333"/> <port id="pr_bdddd665-fb97-4c90-9556-936a2acea9ca_p1" x="2197.0" y="1638.8333"/> <port id="pr_bdddd665-fb97-4c90-9556-936a2acea9ca_p2" x="2227.0" y="1638.8333"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_3876f6c1-a897-4f20-b0e4-d08dd4c4d06d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: The component kinases of the ERK cascade Raf-1 MEK and ERK assemble using beta-ARRESTIN as a scaffold and leading to activation of ERK. Endocytosis of these receptor/beta-ARRESTIN complexes by clathrin-coated pits results in the targeting of activated ERK to endosomal vesicles. The beta-ARRESTIN occupied receptor undergoes internalisation into early endosomes. At the early endosome stage beta-ARRESTIN recruits both MEK1/2 and ERK1/2 and is likely to facilitate their activation upon GPCR stimulation. PMID:11226259 PMID:19565474 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1674.5728" y="2167.7935"/> <port id="pr_3876f6c1-a897-4f20-b0e4-d08dd4c4d06d_p1" x="1664.5728" y="2172.7935"/> <port id="pr_3876f6c1-a897-4f20-b0e4-d08dd4c4d06d_p2" x="1694.5728" y="2172.7935"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b78dd64f-1288-4f58-bda7-94532787d94b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Mxi2 is a splicing isoform of P38. It directly interacts with ERK1/2. Mxi2 prolongs ERK activation (in the nucleus) by binding. Mxi2 could suffice to promote the transport of ERK1/2 to the nucleus in the absence of further stimulation. PMID:12697810 PMID:17255949 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2338.2668" y="2710.9272"/> <port id="pr_b78dd64f-1288-4f58-bda7-94532787d94b_p1" x="2343.2668" y="2700.9272"/> <port id="pr_b78dd64f-1288-4f58-bda7-94532787d94b_p2" x="2343.2668" y="2730.9272"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6c8548bd-0e37-4bb4-8177-ecf7e642c1c7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Calcium activates the Ras GAP CAPRI (RASA4) that translocates to the PM and downregulates any Ras that is activated on this compartment by the exchange factor SOS. PMID:16488589 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="857.375" y="1611.1545"/> <port id="pr_6c8548bd-0e37-4bb4-8177-ecf7e642c1c7_p1" x="877.375" y="1616.1545"/> <port id="pr_6c8548bd-0e37-4bb4-8177-ecf7e642c1c7_p2" x="847.375" y="1616.1545"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d6400353-6d10-445e-9867-52ccc980c632"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Docking of activated ERK to the KSR1 scaffold negatively regulates the interaction between KSR1 and B-Raf. PMID:19541618 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1683.25" y="1756.9314"/> <port id="pr_d6400353-6d10-445e-9867-52ccc980c632_p1" x="1673.25" y="1761.9314"/> <port id="pr_d6400353-6d10-445e-9867-52ccc980c632_p2" x="1703.25" y="1761.9314"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c1e31861-264b-4751-9ddd-4477a7916204"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Results supported the notion that KSR1 coupled activated ERK1/2 selectively to its substrate cPLA2 (PLA2G4A) in response to signals generated at lipid rafts. MAPKs activate cPLA2 (PLA2G4A) by phosphorylation. PMID:19114553 PMID:8381049 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2101.3335" y="2311.6667"/> <port id="pr_c1e31861-264b-4751-9ddd-4477a7916204_p1" x="2091.3335" y="2316.6667"/> <port id="pr_c1e31861-264b-4751-9ddd-4477a7916204_p2" x="2121.3335" y="2316.6667"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_3a7b1808-3305-484c-90ce-9066e7810c8d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Upon activation scaffold proteins serve as platforms in which ERK dimers are assembled forming complexes capable of interacting with and activating cognate cytoplasmic substrates. PMID:18775330 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1805.25" y="2137.0"/> <port id="pr_3a7b1808-3305-484c-90ce-9066e7810c8d_p1" x="1795.25" y="2142.0"/> <port id="pr_3a7b1808-3305-484c-90ce-9066e7810c8d_p2" x="1825.25" y="2142.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_3f582c0c-5232-4f38-b8ea-73a622240f2e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Upon activation scaffold proteins serve as platforms in which ERK dimers are assembled forming complexes capable of interacting with and activating cognate cytoplasmic substrates. Unlike many other scaffolds ERK1/2 do not dissociate from Sef1 upon stimulation and therefore nuclear translocation of the Sef1 anchored fraction of ERK1/2 molecules is blocked. PMID:18775330 PMID:19565474 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="849.5" y="2630.8936"/> <port id="pr_3f582c0c-5232-4f38-b8ea-73a622240f2e_p1" x="869.5" y="2635.8936"/> <port id="pr_3f582c0c-5232-4f38-b8ea-73a622240f2e_p2" x="839.5" y="2635.8936"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_0ff89576-b546-4d17-bd27-e58037f80c1b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Recruited GRKs (GRK2 and GRK3) phosphorylate GPCR and increase its affinity for binding beta-ARRESTIN. PMID:11226259 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2167.0" y="1449.2686"/> <port id="pr_0ff89576-b546-4d17-bd27-e58037f80c1b_p1" x="2157.0" y="1454.2686"/> <port id="pr_0ff89576-b546-4d17-bd27-e58037f80c1b_p2" x="2187.0" y="1454.2686"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f8548cf2-6680-4a86-b063-9d05ea3cc38c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: The internalised GPCR receptor will finally be recycled into the cell membrane or be sent to lysosome for degradation (not modelled). PMID:19565474 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2179.018" y="2196.3142"/> <port id="pr_f8548cf2-6680-4a86-b063-9d05ea3cc38c_p1" x="2199.018" y="2201.3142"/> <port id="pr_f8548cf2-6680-4a86-b063-9d05ea3cc38c_p2" x="2169.018" y="2201.3142"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9a4b50a0-ef64-41ed-aa22-2099d1400f3d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Upon activation scaffold proteins serve as platforms in which ERK dimers are assembled forming complexes capable of interacting with and activating cognate cytoplasmic substrates. Beta-ARRESTIN prevents the translocation of ERK into the nucleus thereby reducing phosphorylation of nuclear substrates and consequently MODULE:MAPK-dependent gene expression. PMID:18775330 PMID:19091303 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2415.974" y="2462.7678"/> <port id="pr_9a4b50a0-ef64-41ed-aa22-2099d1400f3d_p1" x="2405.974" y="2467.7678"/> <port id="pr_9a4b50a0-ef64-41ed-aa22-2099d1400f3d_p2" x="2435.974" y="2467.7678"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_e1098099-ccd8-4c49-b84d-47c3381e4f3f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: DUSP6 may capture activated ERK2 dephosphorylate it and anchor the inactive kinase in the cytoplasm. PMID:17052211 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2268.624" y="2529.755"/> <port id="pr_e1098099-ccd8-4c49-b84d-47c3381e4f3f_p1" x="2288.624" y="2534.755"/> <port id="pr_e1098099-ccd8-4c49-b84d-47c3381e4f3f_p2" x="2258.624" y="2534.755"/> </glyph> <glyph class="process" orientation="vertical" id="pr_d54bc8f1-7a88-462b-b10d-89cdaad7fdbe"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: The rapid and efficient phosphorylation of Elk1 by ERKs is enabled by a direct interaction between the two proteins. ELK1 is a nuclear P38 target. ELK1 is a nuclear JNK target. PMID:16393692 PMID:20506250 PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1398.25" y="2978.0"/> <port id="pr_d54bc8f1-7a88-462b-b10d-89cdaad7fdbe_p1" x="1403.25" y="2968.0"/> <port id="pr_d54bc8f1-7a88-462b-b10d-89cdaad7fdbe_p2" x="1403.25" y="2998.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b67ad3b7-1ad0-4736-96e4-f7d8ede3b199"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: DUSP5 represents an inducible ERK-specific MKP and it functions as both a nuclear anchor and inactivator of ERK MODULE:MAPK in mammalian cells. PMID:17052211 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="768.25586" y="3017.8125"/> <port id="pr_b67ad3b7-1ad0-4736-96e4-f7d8ede3b199_p1" x="773.25586" y="3007.8125"/> <port id="pr_b67ad3b7-1ad0-4736-96e4-f7d8ede3b199_p2" x="773.25586" y="3037.8125"/> </glyph> <glyph class="process" orientation="vertical" id="pr_97118bc7-1386-4ee6-8344-b91ad2383358"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: RSK2 is a well known ERK substrate in the cytoplasm and has been shown to undergo autophosphorylation after ERK phosphorylation. RSKs interact with ERK and dissociate upon activation. Results suggested that KSR1 was the scaffold utilised by ERK1/2 for activating cPLA2 but not RSK1. PMID:15239952 PMID:15187187 PMID:19114553 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1842.75" y="2676.8333"/> <port id="pr_97118bc7-1386-4ee6-8344-b91ad2383358_p1" x="1847.75" y="2666.8333"/> <port id="pr_97118bc7-1386-4ee6-8344-b91ad2383358_p2" x="1847.75" y="2696.8333"/> </glyph> <glyph class="process" orientation="vertical" id="pr_66078d37-0fd5-499b-badd-ff7bfb3d9924"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MSK1 and MSK2 are potently activated (by phosphorylation) in vivo by ERK1/2 and P38 but not JNK. They are localised in the nucleus of quiescent and activated cells which suggest that they may preferentially phosphorylate nuclear substrates. PMID:15187187 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="515.5833" y="2925.3333"/> <port id="pr_66078d37-0fd5-499b-badd-ff7bfb3d9924_p1" x="520.5833" y="2915.3333"/> <port id="pr_66078d37-0fd5-499b-badd-ff7bfb3d9924_p2" x="520.5833" y="2945.3333"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c0933e25-eae5-4cb1-ac44-a8dccedcab1f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MSK1 rather than RSK1 mediates the mitogen-stimulated phoshphorylation of CREB. PMID:15187187 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="565.6667" y="3082.0"/> <port id="pr_c0933e25-eae5-4cb1-ac44-a8dccedcab1f_p1" x="570.6667" y="3072.0"/> <port id="pr_c0933e25-eae5-4cb1-ac44-a8dccedcab1f_p2" x="570.6667" y="3102.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9f72dfec-2cf3-4f06-a9ab-9f4c012b19a8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: RSK2 is a well known ERK substrate in the cytoplasm. Activated RSK can be found in both nuclear and cytoplasmic compartments. PMID:15239952 PMID:15187187 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1569.4937" y="2829.6309"/> <port id="pr_9f72dfec-2cf3-4f06-a9ab-9f4c012b19a8_p1" x="1589.4937" y="2834.6309"/> <port id="pr_9f72dfec-2cf3-4f06-a9ab-9f4c012b19a8_p2" x="1559.4937" y="2834.6309"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c0840ce2-9fa7-41c8-84e2-68fd219337d3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: When Ras assumes an active conformation through binding of GTP a subpopulation of the Raf-1 (C-Raf) protein molecules in cells translocates from the cytosol to the plasma membrane via interaction with P21ras (not modelled). PMID:8929532 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="972.0" y="1775.9943"/> <port id="pr_c0840ce2-9fa7-41c8-84e2-68fd219337d3_p1" x="962.0" y="1780.9943"/> <port id="pr_c0840ce2-9fa7-41c8-84e2-68fd219337d3_p2" x="992.0" y="1780.9943"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1e0ff48d-bade-464c-9571-d1e91861621c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: BCL2 protein can target Raf-1 (C-Raf) to mitochondria. PMID:8929532 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1212.9167" y="1771.5"/> <port id="pr_1e0ff48d-bade-464c-9571-d1e91861621c_p1" x="1217.9167" y="1761.5"/> <port id="pr_1e0ff48d-bade-464c-9571-d1e91861621c_p2" x="1217.9167" y="1791.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9e4d78c3-6935-43c9-a776-f711045251e4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Phosphorylation of beta-catenin (CTNNB1) by GSK-3beta (GSK3B) causes its degradation PMID:16039586 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="377.75" y="2753.5"/> <port id="pr_9e4d78c3-6935-43c9-a776-f711045251e4_p1" x="397.75" y="2758.5"/> <port id="pr_9e4d78c3-6935-43c9-a776-f711045251e4_p2" x="367.75" y="2758.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d6e8e238-c3af-493f-8c8e-5d7bde360033"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Once GSK3B is inactivated beta-catenin (CTNNB1) is stabilised in the cytoplasm and translocate to the nucleus and then interacts with TCF/LEF and upregulates its downstream targets such as cyclin D1 and c-myc (not modelled). PMID:16039586 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="377.3846" y="2816.4614"/> <port id="pr_d6e8e238-c3af-493f-8c8e-5d7bde360033_p1" x="397.3846" y="2821.4614"/> <port id="pr_d6e8e238-c3af-493f-8c8e-5d7bde360033_p2" x="367.3846" y="2821.4614"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c335b9b9-fbc8-4dd1-bc8b-b66d46d88f00"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: In the presence of wnt signals (+wnt) the cytosolic amount of b-catenin increases and thus translocates to the nucleus where it associates with transcription factors of the TCF/ LEF family. Due to its transactivating ability the b-catenin-transcription-factor-co mplex binds to DNA and activates wnt target genes. http://www.gene-regulation.com/info/b-catenin.html References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="340.3846" y="2984.6323"/> <port id="pr_c335b9b9-fbc8-4dd1-bc8b-b66d46d88f00_p1" x="330.3846" y="2989.6323"/> <port id="pr_c335b9b9-fbc8-4dd1-bc8b-b66d46d88f00_p2" x="360.3846" y="2989.6323"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b5bf03dd-5905-4737-bd1e-cf27ac64d193"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: ERK phosphorylates GSK3B to facilitate phosphorylation of GSK3B by p90RSK (RSK) which leads to the inactivation of GSK3B. GSK3B docking to ERK and phosphorylation by ERK are required for inhibition of beta-catenin (CTNNB1) ubiquitination and therefore for its stabilisation. ERK GSK3B and p90RSK (RSK) are in the same complex. PMID:16039586 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1710.5315" y="2782.0908"/> <port id="pr_b5bf03dd-5905-4737-bd1e-cf27ac64d193_p1" x="1715.5315" y="2802.0908"/> <port id="pr_b5bf03dd-5905-4737-bd1e-cf27ac64d193_p2" x="1715.5315" y="2772.0908"/> </glyph> <glyph class="process" orientation="vertical" id="pr_70a66450-3759-4c3b-85c2-cedb150681ee"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: A small fraction of both ERK and GSK3 is constitutively found in a protease-protected mitochondrial compartment. How this fraction of ERK and GSK3 enters mitochondria is an open question. PMID:20080742 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="868.7289" y="2407.4766"/> <port id="pr_70a66450-3759-4c3b-85c2-cedb150681ee_p1" x="873.7289" y="2427.4766"/> <port id="pr_70a66450-3759-4c3b-85c2-cedb150681ee_p2" x="873.7289" y="2397.4766"/> </glyph> <glyph class="process" orientation="vertical" id="pr_4da07250-289c-4d3d-becf-d4dc1b7efa6c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: We postulate a model in which ERK activation inhibits GSK3 activity (by phosphorylation) its association to CYPD and CYPD phosphorylation (by GSK3) leading to PTP desensitisation. PMID:20080742 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1338.0" y="2060.0"/> <port id="pr_4da07250-289c-4d3d-becf-d4dc1b7efa6c_p1" x="1343.0" y="2080.0"/> <port id="pr_4da07250-289c-4d3d-becf-d4dc1b7efa6c_p2" x="1343.0" y="2050.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_318d87ed-7bca-46c6-bfbb-c18cbe551ec9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1283.0" y="1885.5"/> <port id="pr_318d87ed-7bca-46c6-bfbb-c18cbe551ec9_p1" x="1288.0" y="1905.5"/> <port id="pr_318d87ed-7bca-46c6-bfbb-c18cbe551ec9_p2" x="1288.0" y="1875.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a7c9ae95-6b38-4158-ae58-d101006bc6e3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: A small fraction of both ERK and GSK3 is constitutively found in a protease-protected mitochondrial compartment. How this fraction of ERK and GSK3 enters mitochondria is an open question. PMID:20080742 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1947.3282" y="2624.3445"/> <port id="pr_a7c9ae95-6b38-4158-ae58-d101006bc6e3_p1" x="1967.3282" y="2629.3445"/> <port id="pr_a7c9ae95-6b38-4158-ae58-d101006bc6e3_p2" x="1937.3282" y="2629.3445"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ef7c0fa4-a6c0-4559-87e9-2b1e0e9e9745"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: We postulate a model in which ERK activation inhibits GSK3 activity (by phosphorylation) its association to CYPD and CYPD phosphorylation (by GSK3) leading to PTP desensitisation. PMID:20080742 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1209.25" y="2048.75"/> <port id="pr_ef7c0fa4-a6c0-4559-87e9-2b1e0e9e9745_p1" x="1214.25" y="2038.75"/> <port id="pr_ef7c0fa4-a6c0-4559-87e9-2b1e0e9e9745_p2" x="1214.25" y="2068.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_83b04f62-8cd6-47a6-b313-6a00f206ab9a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins. PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2388.4963" y="1429.4344"/> <port id="pr_83b04f62-8cd6-47a6-b313-6a00f206ab9a_p1" x="2378.4963" y="1434.4344"/> <port id="pr_83b04f62-8cd6-47a6-b313-6a00f206ab9a_p2" x="2408.4963" y="1434.4344"/> </glyph> <glyph class="process" orientation="vertical" id="pr_fcac7d9a-7ae7-4508-9b4f-fd58527b2964"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: TRAF proteins are recruited to the TRADD-TNFR1 complex. TRADD couples TNFR1 to TRAF2. PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2419.1504" y="1523.25"/> <port id="pr_fcac7d9a-7ae7-4508-9b4f-fd58527b2964_p1" x="2424.1504" y="1513.25"/> <port id="pr_fcac7d9a-7ae7-4508-9b4f-fd58527b2964_p2" x="2424.1504" y="1543.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_64a89605-a916-41d0-9bc0-a73e8f32382c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: TNF treatment is thought to result in the formation of a TRADD-RIP-TRAF2 complex at the membrane. PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2426.4346" y="1664.25"/> <port id="pr_64a89605-a916-41d0-9bc0-a73e8f32382c_p1" x="2431.4346" y="1654.25"/> <port id="pr_64a89605-a916-41d0-9bc0-a73e8f32382c_p2" x="2431.4346" y="1684.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_52ea4924-bb13-4c4b-8dfc-01ec8a3d7f42"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Upon ligand-induced TNFR1 trimerisation (not modelled) the TNFR1 death domain binds the death domain of the platform adapter protein TRADD. In contrast TNFR2 does not possess a death domain and instead binds directly to TRAF proteins (TRAF2). PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2697.4963" y="1544.4607"/> <port id="pr_52ea4924-bb13-4c4b-8dfc-01ec8a3d7f42_p1" x="2687.4963" y="1549.4607"/> <port id="pr_52ea4924-bb13-4c4b-8dfc-01ec8a3d7f42_p2" x="2717.4963" y="1549.4607"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5690674e-cd92-4e4f-a6f7-d53244b02e2d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: ER stress lead to the oligomerisation and activation of mammalian Ire1p (ERN1). ERN1 activation is likely to trigger binding and activation of TRAF2. PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2908.4963" y="1468.3596"/> <port id="pr_5690674e-cd92-4e4f-a6f7-d53244b02e2d_p1" x="2898.4963" y="1473.3596"/> <port id="pr_5690674e-cd92-4e4f-a6f7-d53244b02e2d_p2" x="2928.4963" y="1473.3596"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_63a11d46-6d0c-4588-933b-6aa85b7c76f1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: The IL-1R/IL-1RAcP heterodimer recruits the death domain adapter protein MyD88. PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3029.4963" y="1445.2057"/> <port id="pr_63a11d46-6d0c-4588-933b-6aa85b7c76f1_p1" x="3019.4963" y="1450.2057"/> <port id="pr_63a11d46-6d0c-4588-933b-6aa85b7c76f1_p2" x="3049.4963" y="1450.2057"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_4c7645c2-0a23-4ce4-9647-a36e606b9ab6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Similar to RIP recruitment by TRADD the death domain of receptor-bound MyD88 binds IRAK1. PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3039.9963" y="1589.0"/> <port id="pr_4c7645c2-0a23-4ce4-9647-a36e606b9ab6_p1" x="3029.9963" y="1594.0"/> <port id="pr_4c7645c2-0a23-4ce4-9647-a36e606b9ab6_p2" x="3059.9963" y="1594.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_0499546c-9149-44fd-91d9-8c6be977f331"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Upon recruitment to the IL-1R complex IRAK1 binds TRAF6 forming a MyD88-IRAK1-TRAF6 complex analogous to the TNFR-associated complex of TRADD RIP and TRAF2. PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3232.0005" y="1623.5"/> <port id="pr_0499546c-9149-44fd-91d9-8c6be977f331_p1" x="3237.0005" y="1613.5"/> <port id="pr_0499546c-9149-44fd-91d9-8c6be977f331_p2" x="3237.0005" y="1643.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_4bf3b409-432b-46c2-b5fa-ea927d0c33e2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Activated TGFBR1/TGFBR2 complex attracts the TAB2/TAB3 proteins which promote activation of TAK1 (by phosphorylation). TAB1 is an essential cofactor required for activation of TAK1 by upstream stimuli. PMID:20060931 PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3447.7463" y="1654.5"/> <port id="pr_4bf3b409-432b-46c2-b5fa-ea927d0c33e2_p1" x="3467.7463" y="1659.5"/> <port id="pr_4bf3b409-432b-46c2-b5fa-ea927d0c33e2_p2" x="3437.7463" y="1659.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b43038b1-66b1-4ffa-b225-c5ccf641121f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Activated TGFBR1/TGFBR2 complex attracts the TAB2/TAB3 proteins which promote activation of TAK1 (by phosphorylation). TAB1 is an essential cofactor required for activation of TAK1 by upstream stimuli. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. PMID:20060931 PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3848.1978" y="2036.5752"/> <port id="pr_b43038b1-66b1-4ffa-b225-c5ccf641121f_p1" x="3853.1978" y="2026.5752"/> <port id="pr_b43038b1-66b1-4ffa-b225-c5ccf641121f_p2" x="3853.1978" y="2056.5752"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5f54347b-4566-4d8e-b200-8326294752ec"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3880.247" y="1924.7244"/> <port id="pr_5f54347b-4566-4d8e-b200-8326294752ec_p1" x="3885.247" y="1914.7244"/> <port id="pr_5f54347b-4566-4d8e-b200-8326294752ec_p2" x="3885.247" y="1944.7244"/> </glyph> <glyph class="process" orientation="vertical" id="pr_f0961a52-9c68-499f-b641-f7738a5307f0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3700.3188" y="1946.5"/> <port id="pr_f0961a52-9c68-499f-b641-f7738a5307f0_p1" x="3705.3188" y="1936.5"/> <port id="pr_f0961a52-9c68-499f-b641-f7738a5307f0_p2" x="3705.3188" y="1966.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1b8bb2a1-1d24-425f-8e3b-3e5fe1d0ee2b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3549.4668" y="1991.6699"/> <port id="pr_1b8bb2a1-1d24-425f-8e3b-3e5fe1d0ee2b_p1" x="3554.4668" y="1981.6699"/> <port id="pr_1b8bb2a1-1d24-425f-8e3b-3e5fe1d0ee2b_p2" x="3554.4668" y="2011.6699"/> </glyph> <glyph class="process" orientation="vertical" id="pr_2ddd57ba-551f-4f59-a912-d3545e587c0f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MEKK1 can interact with Ras in a GTP-dependent manner. The GTP-dependent coupling of MEKK1 to Ras indicates that MEKK1 may be an effector for those agonists that recruit JNK through Ras-dependent mechanisms. PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3413.849" y="1994.8076"/> <port id="pr_2ddd57ba-551f-4f59-a912-d3545e587c0f_p1" x="3418.849" y="1984.8076"/> <port id="pr_2ddd57ba-551f-4f59-a912-d3545e587c0f_p2" x="3418.849" y="2014.8076"/> </glyph> <glyph class="process" orientation="vertical" id="pr_55e4511c-c86e-490a-831c-6f11fff38ee3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MEKK1 is significantly activated by TNF. Oligomerisation of TRAFs is sufficient to trigger MEKK1 binding. MEKK1 associates selectively with oligomerised TRAF2 in vivo in a TNF-dependent manner. PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3112.4277" y="2027.0"/> <port id="pr_55e4511c-c86e-490a-831c-6f11fff38ee3_p1" x="3117.4277" y="2017.0"/> <port id="pr_55e4511c-c86e-490a-831c-6f11fff38ee3_p2" x="3117.4277" y="2047.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_884f5261-e651-44a8-9a38-0d3f9a65f92a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MEKK1 is significantly activated by TNF. Oligomerisation of TRAFs is sufficient to trigger MEKK1 binding. MEKK1 associates selectively with oligomerised TRAF2 in vivo in a TNF-dependent manner. PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2813.1116" y="2047.3118"/> <port id="pr_884f5261-e651-44a8-9a38-0d3f9a65f92a_p1" x="2818.1116" y="2037.3118"/> <port id="pr_884f5261-e651-44a8-9a38-0d3f9a65f92a_p2" x="2818.1116" y="2067.3118"/> </glyph> <glyph class="process" orientation="vertical" id="pr_3c64d572-7b3b-44b8-ad68-7168e2b5bd89"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Activation of MEKK2 and MEKK3 is assumed to follow the same mechanisms of MEKK1 activation References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3268.101" y="1930.3906"/> <port id="pr_3c64d572-7b3b-44b8-ad68-7168e2b5bd89_p1" x="3273.101" y="1920.3906"/> <port id="pr_3c64d572-7b3b-44b8-ad68-7168e2b5bd89_p2" x="3273.101" y="1950.3906"/> </glyph> <glyph class="process" orientation="vertical" id="pr_d75ab7bf-6593-4392-8cac-526300a509af"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Activation of MEKK2 and MEKK3 is assumed to follow the same mechanisms of MEKK1 activation References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3143.9077" y="1944.327"/> <port id="pr_d75ab7bf-6593-4392-8cac-526300a509af_p1" x="3148.9077" y="1934.327"/> <port id="pr_d75ab7bf-6593-4392-8cac-526300a509af_p2" x="3148.9077" y="1964.327"/> </glyph> <glyph class="process" orientation="vertical" id="pr_cadc6ebd-f4bd-47cc-8042-7f0db13f9127"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Activation of MEKK2 and MEKK3 is assumed to follow the same mechanisms of MEKK1 activation References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2830.9824" y="1972.0"/> <port id="pr_cadc6ebd-f4bd-47cc-8042-7f0db13f9127_p1" x="2835.9824" y="1962.0"/> <port id="pr_cadc6ebd-f4bd-47cc-8042-7f0db13f9127_p2" x="2835.9824" y="1992.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2b48d41c-0a3b-42c1-8a48-e59dec0b5c15"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Expression of GADD45 genes in mammalian cells strongly activates co-expressed MTK1 as well as P38 and JNK the MAPKs downstream of MTK1. GADD45alpha/beta are direct MEKK4 interactors. They are involved in genotoxin regulation of MEKK4 signalling to JNK and P38 PMID:21614932 PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4053.4146" y="2215.0256"/> <port id="pr_2b48d41c-0a3b-42c1-8a48-e59dec0b5c15_p1" x="4073.4146" y="2220.0256"/> <port id="pr_2b48d41c-0a3b-42c1-8a48-e59dec0b5c15_p2" x="4043.4146" y="2220.0256"/> </glyph> <glyph class="process" orientation="vertical" id="pr_329a3f0d-7846-47a3-82a9-5a1d75ba3ce0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: TNF-dependent production of ROS triggers the dissociation of Trx from ASK1. PMID:12655147 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4042.525" y="1938.1138"/> <port id="pr_329a3f0d-7846-47a3-82a9-5a1d75ba3ce0_p1" x="4047.525" y="1958.1138"/> <port id="pr_329a3f0d-7846-47a3-82a9-5a1d75ba3ce0_p2" x="4047.525" y="1928.1138"/> </glyph> <glyph class="process" orientation="vertical" id="pr_4eceb807-e373-4d03-a568-532c3ccd33aa"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: TRAF2 activation triggers a ROS pulse that causes the dissociation of Trx from ASK1. PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2753.3794" y="1670.7399"/> <port id="pr_4eceb807-e373-4d03-a568-532c3ccd33aa_p1" x="2758.3794" y="1660.7399"/> <port id="pr_4eceb807-e373-4d03-a568-532c3ccd33aa_p2" x="2758.3794" y="1690.7399"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_45c30aaa-bf5e-4711-a1e2-122bd3fbef14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: TRAF2 activation triggers a ROS pulse that causes the dissociation of Trx from ASK1. PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2762.924" y="1608.8262"/> <port id="pr_45c30aaa-bf5e-4711-a1e2-122bd3fbef14_p1" x="2752.924" y="1613.8262"/> <port id="pr_45c30aaa-bf5e-4711-a1e2-122bd3fbef14_p2" x="2782.924" y="1613.8262"/> </glyph> <glyph class="process" orientation="vertical" id="pr_f3a0ba02-b118-487c-ac31-46a5226b1813"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: TNF-dependent production of ROS triggers the dissociation of Trx from ASK1 and the consequently liberalised ASK1 binds to TRAF2. Finally TRAF2 appears to activate ASK1 (by phosphorylation) by enhancing and stabilising the oligomerisation of ASK1. PMID:12655147 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3967.3528" y="1904.5"/> <port id="pr_f3a0ba02-b118-487c-ac31-46a5226b1813_p1" x="3972.3528" y="1894.5"/> <port id="pr_f3a0ba02-b118-487c-ac31-46a5226b1813_p2" x="3972.3528" y="1924.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_bd6ede8e-3c7f-4c4b-a03e-bbd6ca182d36"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: TNF-dependent production of ROS triggers the dissociation of Trx from ASK1 and the consequently liberalised ASK1 binds to TRAF2. Finally TRAF2 appears to activate ASK1 (by phosphorylation) by enhancing and stabilising the oligomerisation of ASK1. PMID:12655147 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4182.4414" y="1987.3313"/> <port id="pr_bd6ede8e-3c7f-4c4b-a03e-bbd6ca182d36_p1" x="4187.4414" y="1977.3313"/> <port id="pr_bd6ede8e-3c7f-4c4b-a03e-bbd6ca182d36_p2" x="4187.4414" y="2007.3313"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_316438a2-094f-4b77-9692-b73515462cf6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1106.7465" y="1467.6355"/> <port id="pr_316438a2-094f-4b77-9692-b73515462cf6_p1" x="1096.7465" y="1472.6355"/> <port id="pr_316438a2-094f-4b77-9692-b73515462cf6_p2" x="1126.7465" y="1472.6355"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c829e85b-3dac-4679-a869-b01f48b513ae"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Several MAP3Ks upstream of JNK bind RAC1 in a GTP-dependent manner (involving Grb2). PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1075.3715" y="1409.4716"/> <port id="pr_c829e85b-3dac-4679-a869-b01f48b513ae_p1" x="1095.3715" y="1414.4716"/> <port id="pr_c829e85b-3dac-4679-a869-b01f48b513ae_p2" x="1065.3715" y="1414.4716"/> </glyph> <glyph class="process" orientation="vertical" id="pr_66eca9a6-1d17-431a-9d45-a2931e9f9528"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MLK3 and MLK2 two MAP3Ks of JNK pathway can interact with RAC1 in a GTP-dependent manner. PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2888.3667" y="1904.0"/> <port id="pr_66eca9a6-1d17-431a-9d45-a2931e9f9528_p1" x="2893.3667" y="1894.0"/> <port id="pr_66eca9a6-1d17-431a-9d45-a2931e9f9528_p2" x="2893.3667" y="1924.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_65758942-a880-41bf-953a-49707313d6a0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MLK3 and MLK2 two MAP3Ks of JNK pathway can interact with RAC1 in a GTP-dependent manner. MEKK2 and MEKK3 can activate JNK P38 and ERK pathways. TAO kinases are novel MAP3Ks that specifically regulate P38s. ASK1 is a MAP3K and can activate both JNK and P38 pathways. MEKK1 selectively activates the endogenous JNK pathway. MEKK1 can activate MEK4 and MEK7 in vivo. MEKK4 is a MAP3K and can activate both JNK and P38 pathways. TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. MLK3 has the potential to positively regulate the ERK/MODULE:MAPK pathway by directly phosphorylating and activating MEK. Expression of GADD45 genes in mammalian cells strongly activates co-expressed MTK1 as well as P38 and JNK the MAPKs downstream of MTK1. TAO kinases are MAP3Ks that function upstream of P38 and JNK. PMID:11274345 PMID:12738796 PMID:18855897 PMID:21614932 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2847.0308" y="2486.8496"/> <port id="pr_65758942-a880-41bf-953a-49707313d6a0_p1" x="2837.0308" y="2491.8496"/> <port id="pr_65758942-a880-41bf-953a-49707313d6a0_p2" x="2867.0308" y="2491.8496"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d7c65ba3-03a5-4250-8830-03fd07a7b435"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MLK3 and MLK2 two MAP3Ks of JNK pathway can interact with RAC1 in a GTP-dependent manner. MEKK2 and MEKK3 can activate JNK P38 and ERK pathways. TAO kinases are novel MAP3Ks that specifically regulate P38s. ASK1 is a MAP3K and can activate both JNK and P38 pathways. MEKK1 selectively activates the endogenous JNK pathway. MEKK1 can activate MEK4 and MEK7 in vivo. MEKK4 is a MAP3K and can activate both JNK and P38 pathways. TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. MLK3 has the potential to positively regulate the ERK/MODULE:MAPK pathway by directly phosphorylating and activating MEK. Expression of GADD45 genes in mammalian cells strongly activates co-expressed MTK1 as well as P38 and JNK the MAPKs downstream of MTK1. TAO kinases are MAP3Ks that function upstream of P38 and JNK. PMID:11274345 PMID:12738796 PMID:18855897 PMID:21614932 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3646.1782" y="2493.7727"/> <port id="pr_d7c65ba3-03a5-4250-8830-03fd07a7b435_p1" x="3636.1782" y="2498.7727"/> <port id="pr_d7c65ba3-03a5-4250-8830-03fd07a7b435_p2" x="3666.1782" y="2498.7727"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5e513f68-e7f1-439c-be3e-e1223a60ae84"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MEK3 and MEK6 are high selective for P38 activation (by phosphorylation). PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3750.3145" y="2629.5"/> <port id="pr_5e513f68-e7f1-439c-be3e-e1223a60ae84_p1" x="3770.3145" y="2634.5"/> <port id="pr_5e513f68-e7f1-439c-be3e-e1223a60ae84_p2" x="3740.3145" y="2634.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ac67f4bc-44c1-4b94-95f2-8e7cc8f83671"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MEK4 and MEK7 can activate all JNK isoforms (by phosphorylation). PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3036.3145" y="2588.75"/> <port id="pr_ac67f4bc-44c1-4b94-95f2-8e7cc8f83671_p1" x="3056.3145" y="2593.75"/> <port id="pr_ac67f4bc-44c1-4b94-95f2-8e7cc8f83671_p2" x="3026.3145" y="2593.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_1ada76cd-10ce-4378-8cfb-183178d949b2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MLK3 and MLK2 two MAP3Ks of JNK pathway can interact with RAC1 in a GTP-dependent manner. MEKK2 and MEKK3 can activate JNK P38 and ERK pathways. TAO kinases are novel MAP3Ks that specifically regulate P38s. ASK1 is a MAP3K and can activate both JNK and P38 pathways. MEKK1 selectively activates the endogenous JNK pathway. MEKK1 can activate MEK4 and MEK7 in vivo. MEKK4 is a MAP3K and can activate both JNK and P38 pathways. TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. MLK3 has the potential to positively regulate the ERK/MODULE:MAPK pathway by directly phosphorylating and activating MEK. Expression of GADD45 genes in mammalian cells strongly activates co-expressed MTK1 as well as P38 and JNK the MAPKs downstream of MTK1. TAO kinases are MAP3Ks that function upstream of P38 and JNK. PMID:11274345 PMID:12738796 PMID:18855897 PMID:21614932 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3248.2463" y="2491.6667"/> <port id="pr_1ada76cd-10ce-4378-8cfb-183178d949b2_p1" x="3238.2463" y="2496.6667"/> <port id="pr_1ada76cd-10ce-4378-8cfb-183178d949b2_p2" x="3268.2463" y="2496.6667"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2a54d312-2cde-4e92-9dcb-8bc7e9f2d7c7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MLK3 and MLK2 two MAP3Ks of JNK pathway can interact with RAC1 in a GTP-dependent manner. MEKK2 and MEKK3 can activate JNK P38 and ERK pathways. TAO kinases are novel MAP3Ks that specifically regulate P38s. ASK1 is a MAP3K and can activate both JNK and P38 pathways. MEKK1 selectively activates the endogenous JNK pathway. MEKK1 can activate MEK4 and MEK7 in vivo. MEKK4 is a MAP3K and can activate both JNK and P38 pathways. TAK1 is a MAP3K. It is able to activate both JNK and P38 pathways. Endogenous TAK1 is activated by TGF-beta IL-1 and TNF. TAK1 can phosphorylate and activate MEK4 MEK3 and MEK6. MLK3 has the potential to positively regulate the ERK/MODULE:MAPK pathway by directly phosphorylating and activating MEK. Expression of GADD45 genes in mammalian cells strongly activates co-expressed MTK1 as well as P38 and JNK the MAPKs downstream of MTK1. TAO kinases are MAP3Ks that function upstream of P38 and JNK. PMID:11274345 PMID:12738796 PMID:18855897 PMID:21614932 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4004.746" y="2491.6667"/> <port id="pr_2a54d312-2cde-4e92-9dcb-8bc7e9f2d7c7_p1" x="4024.746" y="2496.6667"/> <port id="pr_2a54d312-2cde-4e92-9dcb-8bc7e9f2d7c7_p2" x="3994.746" y="2496.6667"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_255b428c-6689-42bf-a272-70c52fa8f178"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Any other mechanism of ERK activation not explicitly modelled. References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2231.0835" y="2593.6667"/> <port id="pr_255b428c-6689-42bf-a272-70c52fa8f178_p1" x="2221.0835" y="2598.6667"/> <port id="pr_255b428c-6689-42bf-a272-70c52fa8f178_p2" x="2251.0835" y="2598.6667"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f04e9d60-45bf-4a6c-9290-9eb2a4050591"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MAPKAPK2 and MAPKAPK3 are phosphorylated and activated by P38alpha and P38 beta. PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3785.0796" y="2776.5"/> <port id="pr_f04e9d60-45bf-4a6c-9290-9eb2a4050591_p1" x="3805.0796" y="2781.5"/> <port id="pr_f04e9d60-45bf-4a6c-9290-9eb2a4050591_p2" x="3775.0796" y="2781.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_17122180-1232-4aa2-b0f9-6a47bdf97531"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MAPKAPK2 MAPKAPK3 and PRAK catalyse phosphorylation of HSP27. PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3965.5796" y="2988.5"/> <port id="pr_17122180-1232-4aa2-b0f9-6a47bdf97531_p1" x="3985.5796" y="2993.5"/> <port id="pr_17122180-1232-4aa2-b0f9-6a47bdf97531_p2" x="3955.5796" y="2993.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ac2d3ac4-dd71-4a3e-bbb2-d0fbf670a59f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MNKs are cytoplasmic targets of ERK and P38. PMID:15187187 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2188.0796" y="2721.1667"/> <port id="pr_ac2d3ac4-dd71-4a3e-bbb2-d0fbf670a59f_p1" x="2193.0796" y="2711.1667"/> <port id="pr_ac2d3ac4-dd71-4a3e-bbb2-d0fbf670a59f_p2" x="2193.0796" y="2741.1667"/> </glyph> <glyph class="process" orientation="vertical" id="pr_96184df0-cf1e-45c3-9428-700100b61dac"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MAX is phosphorylated by P38 through complex formation (not represented here). PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2948.5796" y="2742.1667"/> <port id="pr_96184df0-cf1e-45c3-9428-700100b61dac_p1" x="2953.5796" y="2732.1667"/> <port id="pr_96184df0-cf1e-45c3-9428-700100b61dac_p2" x="2953.5796" y="2762.1667"/> </glyph> <glyph class="process" orientation="vertical" id="pr_48d189ee-ff15-42d6-91aa-b30ede85a3d0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: P38 and not JNK or ERK can phosphorylate CHOP/GADD153 (DDIT3). PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3153.913" y="3008.1667"/> <port id="pr_48d189ee-ff15-42d6-91aa-b30ede85a3d0_p1" x="3158.913" y="2998.1667"/> <port id="pr_48d189ee-ff15-42d6-91aa-b30ede85a3d0_p2" x="3158.913" y="3028.1667"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_830995f4-455d-4580-8a8b-c2db177c1bb7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: JNK could phosphorylate NFAT4 and NFAT2 inhibiting their nuclear translocation. PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2564.5796" y="2760.5833"/> <port id="pr_830995f4-455d-4580-8a8b-c2db177c1bb7_p1" x="2554.5796" y="2765.5833"/> <port id="pr_830995f4-455d-4580-8a8b-c2db177c1bb7_p2" x="2584.5796" y="2765.5833"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9cf2535a-cff4-449d-a704-8c8477c625eb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: JNK could phosphorylate NFAT4 and NFAT2 inhibiting their nuclear translocation. PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2261.112" y="2824.1357"/> <port id="pr_9cf2535a-cff4-449d-a704-8c8477c625eb_p1" x="2281.112" y="2829.1357"/> <port id="pr_9cf2535a-cff4-449d-a704-8c8477c625eb_p2" x="2251.112" y="2829.1357"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8eb836e1-a7d3-4076-af91-6848bc19adee"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1973.9963" y="3124.0928"/> <port id="pr_8eb836e1-a7d3-4076-af91-6848bc19adee_p1" x="1993.9963" y="3129.0928"/> <port id="pr_8eb836e1-a7d3-4076-af91-6848bc19adee_p2" x="1963.9963" y="3129.0928"/> </glyph> <glyph class="process" orientation="vertical" id="pr_2e2b64dd-ddf5-4312-921c-95910e772b30"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1712.5522" y="2999.4858"/> <port id="pr_2e2b64dd-ddf5-4312-921c-95910e772b30_p1" x="1717.5522" y="3019.4858"/> <port id="pr_2e2b64dd-ddf5-4312-921c-95910e772b30_p2" x="1717.5522" y="2989.4858"/> </glyph> <glyph class="process" orientation="vertical" id="pr_44de867b-5ce8-48e2-8d0c-9b7c32301371"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: AP-1 is a heterodimer comprised of bZIP transcription factors typically C-JUN and JUND along with members of the fos (usually c-FOS) and ATF (usually ATF2) families. All bZIP transcription factors contain leucine zippers that enable homo- and heterodimerisation and AP-1 components are organised into JUN-JUN JUN-FOS or JUN-ATF dimers. PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1565.2021" y="3104.5005"/> <port id="pr_44de867b-5ce8-48e2-8d0c-9b7c32301371_p1" x="1570.2021" y="3124.5005"/> <port id="pr_44de867b-5ce8-48e2-8d0c-9b7c32301371_p2" x="1570.2021" y="3094.5005"/> </glyph> <glyph class="process" orientation="vertical" id="pr_71e59444-3209-491b-a704-4dce0228933e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: ATF2 is a nuclear P38 target. ATF2 is a nuclear JNK target. PMID:20506250 PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2475.0" y="3020.0"/> <port id="pr_71e59444-3209-491b-a704-4dce0228933e_p1" x="2480.0" y="3010.0"/> <port id="pr_71e59444-3209-491b-a704-4dce0228933e_p2" x="2480.0" y="3040.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5640f81d-296c-48e9-ae43-ab06cb092284"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Phosphorylation by both ERKs and their downstream RSKs can stabilise the c-FOS protein for several hours. The combination of these phosphorylations allows c-FOS sustained activity. PMID:16393692 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1146.5815" y="2962.6667"/> <port id="pr_5640f81d-296c-48e9-ae43-ab06cb092284_p1" x="1151.5815" y="2952.6667"/> <port id="pr_5640f81d-296c-48e9-ae43-ab06cb092284_p2" x="1151.5815" y="2982.6667"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ef7777db-9aa7-491a-97a7-4c4ebc5d164b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: JNKs are the dominant kinases responsible for stress- and TNF-activated C-JUN phosphorylation. PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2137.5796" y="2990.1667"/> <port id="pr_ef7777db-9aa7-491a-97a7-4c4ebc5d164b_p1" x="2142.5796" y="2980.1667"/> <port id="pr_ef7777db-9aa7-491a-97a7-4c4ebc5d164b_p2" x="2142.5796" y="3010.1667"/> </glyph> <glyph class="process" orientation="vertical" id="pr_9c3f1a12-52f8-446d-8052-7e4658308dbe"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: P53 is a nuclear P38 target. Activated P38 phosphorylates P53 at several residues including Ser33 and thereby increases the transcriptional activity of P53. ATM phosphorylates P53 at ser15 and stabilize it. PMID:20506250 PMID:21614932 PMID:15140942 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3350.8572" y="2997.4287"/> <port id="pr_9c3f1a12-52f8-446d-8052-7e4658308dbe_p1" x="3355.8572" y="2987.4287"/> <port id="pr_9c3f1a12-52f8-446d-8052-7e4658308dbe_p2" x="3355.8572" y="3017.4287"/> </glyph> <glyph class="process" orientation="vertical" id="pr_0e42e6eb-cbd5-425c-a99a-399be747ccc3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MKP-1 (DUSP1) preferentially inactivates JNK and P38. PMID:19436832 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2370.2007" y="2991.5"/> <port id="pr_0e42e6eb-cbd5-425c-a99a-399be747ccc3_p1" x="2375.2007" y="2981.5"/> <port id="pr_0e42e6eb-cbd5-425c-a99a-399be747ccc3_p2" x="2375.2007" y="3011.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ee245b53-2430-427d-9961-87cced843c8e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MKP-1 (DUSP1) preferentially inactivates JNK and P38. PMID:19436832 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2914.2856" y="3023.5"/> <port id="pr_ee245b53-2430-427d-9961-87cced843c8e_p1" x="2919.2856" y="3013.5"/> <port id="pr_ee245b53-2430-427d-9961-87cced843c8e_p2" x="2919.2856" y="3043.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_94799ed5-2282-4597-afbb-241280c3a64e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Nuclear shuttling of activated P38 is assumed similarly to ERK. References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3281.516" y="2830.5918"/> <port id="pr_94799ed5-2282-4597-afbb-241280c3a64e_p1" x="3301.516" y="2835.5918"/> <port id="pr_94799ed5-2282-4597-afbb-241280c3a64e_p2" x="3271.516" y="2835.5918"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8f4ac7af-bce3-4482-af6f-87a66e3605e2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Nuclear shuttling of activated JNK is assumed similarly to ERK. References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2634.565" y="2829.611"/> <port id="pr_8f4ac7af-bce3-4482-af6f-87a66e3605e2_p1" x="2654.565" y="2834.611"/> <port id="pr_8f4ac7af-bce3-4482-af6f-87a66e3605e2_p2" x="2624.565" y="2834.611"/> </glyph> <glyph class="process" orientation="vertical" id="pr_021d72a8-e7c4-4eb8-b71f-284dd0b69aa9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: TNF-induced ROS cause oxidation and inhibition of DUSP1 and DUSP5. PMID:15766528 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2716.6428" y="2973.0713"/> <port id="pr_021d72a8-e7c4-4eb8-b71f-284dd0b69aa9_p1" x="2721.6428" y="2963.0713"/> <port id="pr_021d72a8-e7c4-4eb8-b71f-284dd0b69aa9_p2" x="2721.6428" y="2993.0713"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a74ed071-feba-472c-aee5-656ab88fd256"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: TNF-induced ROS cause oxidation and inhibition of DUSP1 and DUSP5. PMID:15766528 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="945.5357" y="3044.0713"/> <port id="pr_a74ed071-feba-472c-aee5-656ab88fd256_p1" x="950.5357" y="3034.0713"/> <port id="pr_a74ed071-feba-472c-aee5-656ab88fd256_p2" x="950.5357" y="3064.0713"/> </glyph> <glyph class="process" orientation="vertical" id="pr_6ba68a64-1134-404d-8d06-ee02e19ff715"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MLK3 and MLK2 two MAP3Ks of JNK pathway can interact with RAC1 in a GTP-dependent manner. MEKK2 and MEKK3 can activate JNK P38 and ERK pathways MLK3 has the potential to positively regulate the ERK/MODULE:MAPK pathway by directly phosphorylating and activating MEK. PMID:11274345 PMID:12738796 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2017.4702" y="2597.8452"/> <port id="pr_6ba68a64-1134-404d-8d06-ee02e19ff715_p1" x="2022.4702" y="2587.8452"/> <port id="pr_6ba68a64-1134-404d-8d06-ee02e19ff715_p2" x="2022.4702" y="2617.8452"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_08ace191-fcf5-4f26-aeeb-64ed25349fc1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: JNK pathway negatively regulates ERK pathway by uncoupling ERK activation from MEK via activation of JUN transcriptional activity. A direct interaction between P38 and ERK has been proposed as a mechanism to inhibit ERK phosphorylation. AP-1 mediated gene expression inhibits ERK phosphorylation. PMID:12738796 PMID:18039929 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2231.0835" y="2612.4167"/> <port id="pr_08ace191-fcf5-4f26-aeeb-64ed25349fc1_p1" x="2251.0835" y="2617.4167"/> <port id="pr_08ace191-fcf5-4f26-aeeb-64ed25349fc1_p2" x="2221.0835" y="2617.4167"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8463a6cb-6bef-43f3-9404-699dc297e124"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: P38 is able to suppress RAS-dependent JNK activation (probably through PRAK and MK2). PMID:10978313 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3036.3145" y="2601.25"/> <port id="pr_8463a6cb-6bef-43f3-9404-699dc297e124_p1" x="3026.3145" y="2606.25"/> <port id="pr_8463a6cb-6bef-43f3-9404-699dc297e124_p2" x="3056.3145" y="2606.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_dd980677-8218-495b-82da-e89b54a13d96"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. A direct interaction between P38 and ERK has been proposed as a mechanism to inhibit ERK phosphorylation. AP-1 mediated gene expression inhibits ERK phosphorylation. PMID:18039929 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1785.5939" y="2243.5"/> <port id="pr_dd980677-8218-495b-82da-e89b54a13d96_p1" x="1790.5939" y="2233.5"/> <port id="pr_dd980677-8218-495b-82da-e89b54a13d96_p2" x="1790.5939" y="2263.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_55ef6a66-a47f-47d2-9d2d-b696bc7622b8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1992.4702" y="2597.8452"/> <port id="pr_55ef6a66-a47f-47d2-9d2d-b696bc7622b8_p1" x="1997.4702" y="2617.8452"/> <port id="pr_55ef6a66-a47f-47d2-9d2d-b696bc7622b8_p2" x="1997.4702" y="2587.8452"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_88748569-6f64-48ab-a0bc-21655fe13129"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. A direct interaction between P38 and ERK has been proposed as a mechanism to inhibit ERK phosphorylation. AP-1 mediated gene expression inhibits ERK phosphorylation. PMID:18039929 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1231.5" y="2474.5967"/> <port id="pr_88748569-6f64-48ab-a0bc-21655fe13129_p1" x="1221.5" y="2479.5967"/> <port id="pr_88748569-6f64-48ab-a0bc-21655fe13129_p2" x="1251.5" y="2479.5967"/> </glyph> <glyph class="process" orientation="vertical" id="pr_08a83097-3e0e-4650-8835-728c3a1d0ba3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. A direct interaction between P38 and ERK has been proposed as a mechanism to inhibit ERK phosphorylation. AP-1 mediated gene expression inhibits ERK phosphorylation. PMID:18039929 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2291.8203" y="2074.5"/> <port id="pr_08a83097-3e0e-4650-8835-728c3a1d0ba3_p1" x="2296.8203" y="2094.5"/> <port id="pr_08a83097-3e0e-4650-8835-728c3a1d0ba3_p2" x="2296.8203" y="2064.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6d4ad592-5f40-435d-a117-9ae10ef2dd1f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. A direct interaction between P38 and ERK has been proposed as a mechanism to inhibit ERK phosphorylation. AP-1 mediated gene expression inhibits ERK phosphorylation. PMID:18039929 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1626.8928" y="2507.7065"/> <port id="pr_6d4ad592-5f40-435d-a117-9ae10ef2dd1f_p1" x="1616.8928" y="2512.7065"/> <port id="pr_6d4ad592-5f40-435d-a117-9ae10ef2dd1f_p2" x="1646.8928" y="2512.7065"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_7977c20b-b94f-430f-97e7-cd55dfe2cf0a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MEK is continuously dephosphorylated by PP2A (PPP2CA) whose activity is stimulated by P38: P38 activity increases the physical association between PP2A and MEK/ERK complex. PMID:18039929 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2161.25" y="2381.3333"/> <port id="pr_7977c20b-b94f-430f-97e7-cd55dfe2cf0a_p1" x="2181.25" y="2386.3333"/> <port id="pr_7977c20b-b94f-430f-97e7-cd55dfe2cf0a_p2" x="2151.25" y="2386.3333"/> </glyph> <glyph class="process" orientation="vertical" id="pr_0220a191-25d0-4a58-b658-af352a7084d0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: CREB target genes (c-FOS EGR-1 MKP1 BCL2 MMP13). PMID:19815709 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="518.78815" y="3215.8713"/> <port id="pr_0220a191-25d0-4a58-b658-af352a7084d0_p1" x="523.78815" y="3205.8713"/> <port id="pr_0220a191-25d0-4a58-b658-af352a7084d0_p2" x="523.78815" y="3235.8713"/> </glyph> <glyph class="process" orientation="vertical" id="pr_64dfe150-c5f2-4556-9284-7b490af1cb77"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: CREB target genes (c-FOS EGR-1 MKP1 BCL2 MMP13). PMID:19815709 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="519.29846" y="3215.8071"/> <port id="pr_64dfe150-c5f2-4556-9284-7b490af1cb77_p1" x="524.29846" y="3205.8071"/> <port id="pr_64dfe150-c5f2-4556-9284-7b490af1cb77_p2" x="524.29846" y="3235.8071"/> </glyph> <glyph class="process" orientation="vertical" id="pr_62bc7a63-b1d7-40bf-9379-82e0c29b7769"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: CREB target genes (c-FOS EGR-1 MKP1 BCL2 MMP13). PMID:19815709 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="518.69684" y="3215.621"/> <port id="pr_62bc7a63-b1d7-40bf-9379-82e0c29b7769_p1" x="523.69684" y="3205.621"/> <port id="pr_62bc7a63-b1d7-40bf-9379-82e0c29b7769_p2" x="523.69684" y="3235.621"/> </glyph> <glyph class="process" orientation="vertical" id="pr_584789cc-c021-4fad-adf9-eec0a99f6799"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: CREB target genes (c-FOS EGR-1 MKP1 BCL2 MMP13). PMID:19815709 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="518.8235" y="3215.3984"/> <port id="pr_584789cc-c021-4fad-adf9-eec0a99f6799_p1" x="523.8235" y="3205.3984"/> <port id="pr_584789cc-c021-4fad-adf9-eec0a99f6799_p2" x="523.8235" y="3235.3984"/> </glyph> <glyph class="process" orientation="vertical" id="pr_4847a669-2f38-4a5e-80fb-7a81261f0d90"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: CREB target genes (c-FOS EGR-1 MKP1 BCL2 MMP13). PMID:19815709 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="518.53687" y="3215.6372"/> <port id="pr_4847a669-2f38-4a5e-80fb-7a81261f0d90_p1" x="523.53687" y="3205.6372"/> <port id="pr_4847a669-2f38-4a5e-80fb-7a81261f0d90_p2" x="523.53687" y="3235.6372"/> </glyph> <glyph class="process" orientation="vertical" id="pr_134dba57-7387-4556-a607-7ad229e01257"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Expression of GADD45 is the culmination of a signaling pathway that requires prior expression of the tumor suppressor protein P53 which trans-activates the GADD45 gene. PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3364.9927" y="3183.2764"/> <port id="pr_134dba57-7387-4556-a607-7ad229e01257_p1" x="3369.9927" y="3173.2764"/> <port id="pr_134dba57-7387-4556-a607-7ad229e01257_p2" x="3369.9927" y="3203.2764"/> </glyph> <glyph class="process" orientation="vertical" id="pr_42470d2f-ca19-4c9f-8bdd-f9c45449747e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: P53 target genes: P21WAF1 MDM2 PERP NOXA GADD45 DDB2. PMID:15856024 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3364.685" y="3182.9062"/> <port id="pr_42470d2f-ca19-4c9f-8bdd-f9c45449747e_p1" x="3369.685" y="3172.9062"/> <port id="pr_42470d2f-ca19-4c9f-8bdd-f9c45449747e_p2" x="3369.685" y="3202.9062"/> </glyph> <glyph class="process" orientation="vertical" id="pr_e55c1ed4-1347-46ff-8fcc-0ed74b811415"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: P53 target genes: P21WAF1 MDM2 PERP NOXA GADD45 DDB2. PMID:15856024 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3365.1777" y="3183.1506"/> <port id="pr_e55c1ed4-1347-46ff-8fcc-0ed74b811415_p1" x="3370.1777" y="3173.1506"/> <port id="pr_e55c1ed4-1347-46ff-8fcc-0ed74b811415_p2" x="3370.1777" y="3203.1506"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ef378d8a-1d6e-42ac-a9d8-53e5c8134c42"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: P53 target genes: P21WAF1 MDM2 PERP NOXA GADD45 DDB2. The MDM2 gene is transcriptionally inhibited by P14. PMID:15856024 PMID:17158541 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3353.1072" y="3132.4287"/> <port id="pr_ef378d8a-1d6e-42ac-a9d8-53e5c8134c42_p1" x="3358.1072" y="3122.4287"/> <port id="pr_ef378d8a-1d6e-42ac-a9d8-53e5c8134c42_p2" x="3358.1072" y="3152.4287"/> </glyph> <glyph class="process" orientation="vertical" id="pr_bd6be792-25b7-48b9-bff8-47113ff5fb61"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: P53 target genes: P21WAF1 MDM2 PERP NOXA GADD45 DDB2. PMID:15856024 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3365.0552" y="3183.1108"/> <port id="pr_bd6be792-25b7-48b9-bff8-47113ff5fb61_p1" x="3370.0552" y="3173.1108"/> <port id="pr_bd6be792-25b7-48b9-bff8-47113ff5fb61_p2" x="3370.0552" y="3203.1108"/> </glyph> <glyph class="process" orientation="vertical" id="pr_915325a5-01be-40a9-a4f0-68b897b55699"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: P53 target genes: P21WAF1 MDM2 PERP NOXA GADD45 DDB2. PMID:15856024 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3364.4858" y="3183.1323"/> <port id="pr_915325a5-01be-40a9-a4f0-68b897b55699_p1" x="3369.4858" y="3173.1323"/> <port id="pr_915325a5-01be-40a9-a4f0-68b897b55699_p2" x="3369.4858" y="3203.1323"/> </glyph> <glyph class="process" orientation="vertical" id="pr_bb6dd601-83cc-4c40-a8f7-a9e9fb7921ce"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: ELK1 induces c-fos expression. PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1397.7256" y="3185.829"/> <port id="pr_bb6dd601-83cc-4c40-a8f7-a9e9fb7921ce_p1" x="1402.7256" y="3175.829"/> <port id="pr_bb6dd601-83cc-4c40-a8f7-a9e9fb7921ce_p2" x="1402.7256" y="3205.829"/> </glyph> <glyph class="process" orientation="vertical" id="pr_0129b9e1-3c60-4d02-b171-7a4cfd9a0fbd"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: A mitochondrial pool of Raf-1 (C-RAF) molecules which do not activate MEK reportedly exert their prosurvival effects upstream of cytochrome c release by phosphorylating the pro-apoptotic Bcl-2 family member BAD. Phosphorylation of BAD results in its translocation to the cytosol and ultimately in the inhibition of cytochrome c release. PMID:12107820 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="80.75599" y="2813.0413"/> <port id="pr_0129b9e1-3c60-4d02-b171-7a4cfd9a0fbd_p1" x="85.75599" y="2803.0413"/> <port id="pr_0129b9e1-3c60-4d02-b171-7a4cfd9a0fbd_p2" x="85.75599" y="2833.0413"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a2297de9-004a-4ad4-b356-90130f300289"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Translation References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="73.85504" y="2674.448"/> <port id="pr_a2297de9-004a-4ad4-b356-90130f300289_p1" x="78.85504" y="2694.448"/> <port id="pr_a2297de9-004a-4ad4-b356-90130f300289_p2" x="78.85504" y="2664.448"/> </glyph> <glyph class="process" orientation="vertical" id="pr_52aadc53-483d-4240-ad10-ac273f6fb796"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Translation References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1080.754" y="3080.232"/> <port id="pr_52aadc53-483d-4240-ad10-ac273f6fb796_p1" x="1085.754" y="3100.232"/> <port id="pr_52aadc53-483d-4240-ad10-ac273f6fb796_p2" x="1085.754" y="3070.232"/> </glyph> <glyph class="omitted process" orientation="vertical" id="pr_28581313-4736-4681-9927-3c0b0671d6b2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Translation References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4263.467" y="3054.9402"/> <port id="pr_28581313-4736-4681-9927-3c0b0671d6b2_p1" x="4268.467" y="3074.9402"/> <port id="pr_28581313-4736-4681-9927-3c0b0671d6b2_p2" x="4268.467" y="3044.9402"/> </glyph> <glyph class="process" orientation="vertical" id="pr_196dd1d4-a66e-45dc-8074-f86791927957"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: The Mdm2 protein is involved in an autoregulatory feedback loop with P53 thus controlling its activity. Increased P53 levels transactivate the MDM2 promoter causing its upregulation. The translated protein then binds to P53 and transports it to the proteasome for ubiquitin-mediated degradation. PMID:17158541 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3375.8572" y="2997.4287"/> <port id="pr_196dd1d4-a66e-45dc-8074-f86791927957_p1" x="3380.8572" y="3017.4287"/> <port id="pr_196dd1d4-a66e-45dc-8074-f86791927957_p2" x="3380.8572" y="2987.4287"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_08eb4d2d-86ce-4a9b-b252-efb20fb53c57"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Translation References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2539.463" y="3307.4739"/> <port id="pr_08eb4d2d-86ce-4a9b-b252-efb20fb53c57_p1" x="2529.463" y="3312.4739"/> <port id="pr_08eb4d2d-86ce-4a9b-b252-efb20fb53c57_p2" x="2559.463" y="3312.4739"/> </glyph> <glyph class="process" orientation="vertical" id="pr_bb6eddc1-d5fa-4f89-b8e1-18b5b561073d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Activated caspase-9 cleaves and activates caspase-3 leading to apoptosis. PMID:9390557 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="81.132866" y="2812.6309"/> <port id="pr_bb6eddc1-d5fa-4f89-b8e1-18b5b561073d_p1" x="86.132866" y="2802.6309"/> <port id="pr_bb6eddc1-d5fa-4f89-b8e1-18b5b561073d_p2" x="86.132866" y="2832.6309"/> </glyph> <glyph class="process" orientation="vertical" id="pr_84c1ee2f-7f43-4c6e-abc4-ecbb0dc042a1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: CHOP/GADD153 (DDIT3) mediates in part cell cycle arrest at G1/S an important consequence of DNA damage. It is phosphorylated by P38. PMID:11274345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2769.0144" y="3316.7737"/> <port id="pr_84c1ee2f-7f43-4c6e-abc4-ecbb0dc042a1_p1" x="2774.0144" y="3306.7737"/> <port id="pr_84c1ee2f-7f43-4c6e-abc4-ecbb0dc042a1_p2" x="2774.0144" y="3336.7737"/> </glyph> <glyph class="process" orientation="vertical" id="pr_dddf86e2-a133-439b-9420-5d9f05fd9251"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: TGF-?? exerts its biological effects by binding to a cell surface receptor complex composed of type I (TbRI) and type II (TbRII) receptor serine/threonine kinases. Upon ligand binding TbRII phosphorylates and activates TbRI which subsequently phosphorylates the cytoplasmic Smad2 and Smad3 proteins. Phosphorylated Smad proteins form stable complexes with a common partner Smad4. The activated Smad2/4 and Smad3/4 complexes translocate into the nucleus where the Smad oligomers induce transcriptional activation (or inhibition) of specific target genes. PMID:21614932 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4045.0" y="2802.0"/> <port id="pr_dddf86e2-a133-439b-9420-5d9f05fd9251_p1" x="4050.0" y="2792.0"/> <port id="pr_dddf86e2-a133-439b-9420-5d9f05fd9251_p2" x="4050.0" y="2822.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_d78ef261-5c3b-4248-8ecf-5b134d092184"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: TGF-?? exerts its biological effects by binding to a cell surface receptor complex composed of type I (TbRI) and type II (TbRII) receptor serine/threonine kinases. Upon ligand binding TbRII phosphorylates and activates TbRI which subsequently phosphorylates the cytoplasmic Smad2 and Smad3 proteins. Phosphorylated Smad proteins form stable complexes with a common partner Smad4. The activated Smad2/4 and Smad3/4 complexes translocate into the nucleus where the Smad oligomers induce transcriptional activation (or inhibition) of specific target genes. PMID:21614932 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4125.0" y="2792.0"/> <port id="pr_d78ef261-5c3b-4248-8ecf-5b134d092184_p1" x="4130.0" y="2782.0"/> <port id="pr_d78ef261-5c3b-4248-8ecf-5b134d092184_p2" x="4130.0" y="2812.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9b371664-78f8-4499-be9e-e36c8a573deb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Activation of P38 by TGF-?? is mediated mainly by Smad-dependent GADD45?? expression and by its subsequent activation of MTK1. PMID:21614932 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3631.75" y="3163.75"/> <port id="pr_9b371664-78f8-4499-be9e-e36c8a573deb_p1" x="3651.75" y="3168.75"/> <port id="pr_9b371664-78f8-4499-be9e-e36c8a573deb_p2" x="3621.75" y="3168.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_aeee12fa-f65c-4124-9ba0-bf5f68e2226e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Activation of P38 by TGF-?? is mediated mainly by Smad-dependent GADD45?? expression and by its subsequent activation of MTK1. PMID:21614932 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3691.75" y="3163.75"/> <port id="pr_aeee12fa-f65c-4124-9ba0-bf5f68e2226e_p1" x="3711.75" y="3168.75"/> <port id="pr_aeee12fa-f65c-4124-9ba0-bf5f68e2226e_p2" x="3681.75" y="3168.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1a939095-7138-4ca2-93a4-1a1cf053f5ad"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Ataxia telangiectasia mutated (ATM) is activated in response to DNA damage and directly phosphorylates TAOK. PMID:18855897 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4071.5" y="2294.75"/> <port id="pr_1a939095-7138-4ca2-93a4-1a1cf053f5ad_p1" x="4076.5" y="2284.75"/> <port id="pr_1a939095-7138-4ca2-93a4-1a1cf053f5ad_p2" x="4076.5" y="2314.75"/> </glyph> <glyph class="omitted process" orientation="vertical" id="pr_b3040e65-85a4-4dee-84c8-644554e3ab17"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Translation References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3233.25" y="3182.5"/> <port id="pr_b3040e65-85a4-4dee-84c8-644554e3ab17_p1" x="3238.25" y="3202.5"/> <port id="pr_b3040e65-85a4-4dee-84c8-644554e3ab17_p2" x="3238.25" y="3172.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_3ad4fb14-cbf9-4ed9-b539-05c835d08eee"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MYC activates P14 PMID:17158541 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3241.8315" y="3225.0"/> <port id="pr_3ad4fb14-cbf9-4ed9-b539-05c835d08eee_p1" x="3261.8315" y="3230.0"/> <port id="pr_3ad4fb14-cbf9-4ed9-b539-05c835d08eee_p2" x="3231.8315" y="3230.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_7857762c-ca8f-42b6-b21e-b5afa672e905"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Translation References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3003.75" y="3195.0"/> <port id="pr_7857762c-ca8f-42b6-b21e-b5afa672e905_p1" x="2993.75" y="3200.0"/> <port id="pr_7857762c-ca8f-42b6-b21e-b5afa672e905_p2" x="3023.75" y="3200.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_8bb6403c-b505-4d39-8be2-f00fc998bfb1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Translation References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3194.3315" y="3385.0"/> <port id="pr_8bb6403c-b505-4d39-8be2-f00fc998bfb1_p1" x="3184.3315" y="3390.0"/> <port id="pr_8bb6403c-b505-4d39-8be2-f00fc998bfb1_p2" x="3214.3315" y="3390.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_3ff9adf9-75e1-4995-bac2-71548b48c102"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Translocation of ERK into the nucleus activates the mitogen activated and stress-activated protein kinase 1 (MSK1) a histone H3 kinase that can relax chromatin thus making it more transcriptionally accessible. This alteration in the chromatin state induces MYC a gene that encodes the C-MYC protein a transcription factor that controls the cell cycle. PMID:17158541 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="684.99994" y="3158.583"/> <port id="pr_3ff9adf9-75e1-4995-bac2-71548b48c102_p1" x="689.99994" y="3148.583"/> <port id="pr_3ff9adf9-75e1-4995-bac2-71548b48c102_p2" x="689.99994" y="3178.583"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1d70829e-8e46-4909-b0f4-76cbe1b98e60"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: JNK phosphorylates MST1 at serine 82 which leads to the enhancement of MST1 activation. The activation of MST1 phosphorylates FOXO3 at serine 207 and promotes cell death. PMID:20028971 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2535.0" y="3010.0"/> <port id="pr_1d70829e-8e46-4909-b0f4-76cbe1b98e60_p1" x="2540.0" y="3030.0"/> <port id="pr_1d70829e-8e46-4909-b0f4-76cbe1b98e60_p2" x="2540.0" y="3000.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_005c5f1b-22ef-4698-9480-e268151ad9a9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: JNK phosphorylates MST1 at serine 82 which leads to the enhancement of MST1 activation. The activation of MST1 phosphorylates FOXO3 at serine 207 and promotes cell death. Phosphorylation of FOXO3 by Akt creates a binding site for the 14-3-3 family of proteins. The complex of FOXO3 and 14-3-3 is retained in the cytosol blocking transcription of genes normally stimulated by FOXO3. PMID:20028971 PMID:12040186 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2623.75" y="3085.0"/> <port id="pr_005c5f1b-22ef-4698-9480-e268151ad9a9_p1" x="2628.75" y="3105.0"/> <port id="pr_005c5f1b-22ef-4698-9480-e268151ad9a9_p2" x="2628.75" y="3075.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1bbb9807-f258-4609-8139-f12f2e3216b5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Recruitment to the membrane and tyrosine phosphorylation enhance the enzymatic activity of PLC-g leading to the formation of two second messengers diacylglycerol (DAG) and inositol 145-trisphosphate (IP3). IP3 releases Ca2+ from internal stores which in turn acts in concert with DAG to translocate protein kinase C (PKC) to the cell membrane and stimulate its enzymatic activity. PMID:15567848 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="614.23193" y="1552.125"/> <port id="pr_1bbb9807-f258-4609-8139-f12f2e3216b5_p1" x="619.23193" y="1572.125"/> <port id="pr_1bbb9807-f258-4609-8139-f12f2e3216b5_p2" x="619.23193" y="1542.125"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8daa4012-066f-4e66-8c38-e6d80b25ed4a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PDK1 is a PI3K target leading to activation of P70 (through phosphorylation) and subsequent cell growth. P70 activation requires both ERK cascade and PI3K/AKT cascade at least in some cell types. PMID:12040186 PMID:11940578 PMID:10601235 PMID:11431469 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="599.5" y="2806.25"/> <port id="pr_8daa4012-066f-4e66-8c38-e6d80b25ed4a_p1" x="589.5" y="2811.25"/> <port id="pr_8daa4012-066f-4e66-8c38-e6d80b25ed4a_p2" x="619.5" y="2811.25"/> </glyph> <glyph class="and" orientation="vertical" id="logicglyph_7da737ee-a796-4358-83f8-6614e50bb0e9"> <bbox w="20.0" h="20.0" x="596.5985" y="2790.3218"/> <port id="logicglyph_7da737ee-a796-4358-83f8-6614e50bb0e9_p1" x="606.5985" y="2780.3218"/> <port id="logicglyph_7da737ee-a796-4358-83f8-6614e50bb0e9_p2" x="606.5985" y="2820.3218"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8ceebcf1-7fc9-422d-9525-253c6fe7bb54"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Grb2 recruits the docking protein Gab1 which is tyrosine phosphorylated by FGFR leading to recruitment and activation of the PI3K-Akt cell survival pathway. PMID:15567848 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1003.5" y="1960.0"/> <port id="pr_8ceebcf1-7fc9-422d-9525-253c6fe7bb54_p1" x="1023.5" y="1965.0"/> <port id="pr_8ceebcf1-7fc9-422d-9525-253c6fe7bb54_p2" x="993.5" y="1965.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_576c034e-e2fe-4cc4-9bab-0d83e21d5f96"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PDK1 is a PI3K target leading to activation of P70 and subsequent cell growth. Signaling proteins with pleckstrin-homology (PH) domains accumulate at sites of PI3K activation by directly binding to PI(345)P3. Of particular interest are the protein serine-threonine kinases Akt and phosphoinositide-dependent kinase 1 (PDK1). Association with PI(345)P3 at the membrane brings these proteins into proximity and facilitates phosphorylation of Akt by PDK1. This phosphorylation stimulates the catalytic activity of Akt resulting in the phosphorylation of a host of other proteins that affect cell growth cell cycle entry and cell survival. PMID:12040186 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="908.0" y="2055.0"/> <port id="pr_576c034e-e2fe-4cc4-9bab-0d83e21d5f96_p1" x="898.0" y="2060.0"/> <port id="pr_576c034e-e2fe-4cc4-9bab-0d83e21d5f96_p2" x="928.0" y="2060.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_80722c41-3f99-4362-b38d-fbda7b489f86"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PDK1 is a PI3K target leading to activation of P70 and subsequent cell growth. Signaling proteins with pleckstrin-homology (PH) domains accumulate at sites of PI3K activation by directly binding to PI(345)P3. Of particular interest are the protein serine-threonine kinases Akt and phosphoinositide-dependent kinase 1 (PDK1). Association with PI(345)P3 at the membrane brings these proteins into proximity and facilitates phosphorylation of Akt by PDK1. This phosphorylation stimulates the catalytic activity of Akt resulting in the phosphorylation of a host of other proteins that affect cell growth cell cycle entry and cell survival. PMID:12040186 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="655.0" y="2604.75"/> <port id="pr_80722c41-3f99-4362-b38d-fbda7b489f86_p1" x="660.0" y="2594.75"/> <port id="pr_80722c41-3f99-4362-b38d-fbda7b489f86_p2" x="660.0" y="2624.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5d8ca5b3-0f3e-4ba8-9320-cb53908e7c09"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: P21 is a direct substrate of AKT and this may regulate the subcellular localisation of P21. Phosphorylation of P21 by AKT correlated with its exit from the nucleus and with increased cell cycle progression. PMID:11882383 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="175.0" y="2825.0"/> <port id="pr_5d8ca5b3-0f3e-4ba8-9320-cb53908e7c09_p1" x="180.0" y="2845.0"/> <port id="pr_5d8ca5b3-0f3e-4ba8-9320-cb53908e7c09_p2" x="180.0" y="2815.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_863779c2-2b88-4404-8426-8932f4d03aa1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Akt phosphorylation of the apoptosis-inducing protein BAD creates a binding site for 14-3-3 proteins and prevents BAD from binding to Bcl-2 family members Bcl-2 and Bcl-XL thus releasing them for a cell survival response. PMID:12040186 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1232.0" y="1971.125"/> <port id="pr_863779c2-2b88-4404-8426-8932f4d03aa1_p1" x="1237.0" y="1961.125"/> <port id="pr_863779c2-2b88-4404-8426-8932f4d03aa1_p2" x="1237.0" y="1991.125"/> </glyph> <glyph class="process" orientation="vertical" id="pr_458541e7-ccfa-42ab-9a9e-5dd8054a8564"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Glycogen synthase kinase 3 (GSK3) is a target of Akt. This protein kinase is constitutively active in unstimulated cells and phosphorylates many proteins (including glycogen synthase C-MYC and cyclin D) to keep them in inactive states or promote their degradation. Phosphorylation of GSK3 (both alpha and beta isoforms) by Akt turns off the catalytic activity of this enzyme resulting in the activation of pathways that are normally repressed by GSK3. PMID:12040186 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="759.75" y="2723.625"/> <port id="pr_458541e7-ccfa-42ab-9a9e-5dd8054a8564_p1" x="764.75" y="2713.625"/> <port id="pr_458541e7-ccfa-42ab-9a9e-5dd8054a8564_p2" x="764.75" y="2743.625"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b3ba95c0-776b-481f-b3f8-8db040e7bf71"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: EGF and FGF can induce cell cycle arrest through activation of STAT1 transcription factor. PMID:15567848 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="284.0" y="3117.75"/> <port id="pr_b3ba95c0-776b-481f-b3f8-8db040e7bf71_p1" x="289.0" y="3137.75"/> <port id="pr_b3ba95c0-776b-481f-b3f8-8db040e7bf71_p2" x="289.0" y="3107.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_69333014-0db8-490e-9fb0-fcfbb54dd0e0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: FGF stimulation leads to phosphorylation of Shp2 on a tyrosine residue that forms a complex with an additional molecule of Grb2. Grb2/Sos complexes are thus recruited directly and indirectly via Shp2 upon tyrosine phosphorylation of FRS2a in response to growth factor stimulation. FGF-induced tyrosine phosphorylation of FRS2 results in complex formation with the adaptor protein Grb2 bound to Cbl by means of its SH3 domains. FGF-induced ternary complex formation among FRS2 Grb2 and Cbl results in ubiquitination and degradation of FRS2 and FGF receptor (FGFR). Spry is induced by activated ERK through phosphorylation on Tyr55. It positively regulates EGFR signalling by sequestering Cbl whereas it negatively regulates FGFR signalling by sequestering Grb2 from FSR2. PMID:11447289 PMID:11997436 PMID:15173823 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="955.0" y="1425.0"/> <port id="pr_69333014-0db8-490e-9fb0-fcfbb54dd0e0_p1" x="960.0" y="1445.0"/> <port id="pr_69333014-0db8-490e-9fb0-fcfbb54dd0e0_p2" x="960.0" y="1415.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_0e79bb98-fc33-49fc-a1e7-67222ad7756d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Sprouty is induced by activated ERK through phosphorylation on Tyr55. It positively regulates EGFR signalling by sequestering Cbl whereas it negatively regulates FGFR signalling by sequestering Grb2 from FSR2. PMID:15173823 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2670.0" y="2625.0"/> <port id="pr_0e79bb98-fc33-49fc-a1e7-67222ad7756d_p1" x="2675.0" y="2615.0"/> <port id="pr_0e79bb98-fc33-49fc-a1e7-67222ad7756d_p2" x="2675.0" y="2645.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d0dd53fc-6a16-4b85-b828-b02db7a28c98"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: In response to genotoxic stress such as DNA damage PUMA is transactivated by P53 (leading to apoptosis). PMID:19641508 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2212.9102" y="3545.6768"/> <port id="pr_d0dd53fc-6a16-4b85-b828-b02db7a28c98_p1" x="2232.9102" y="3550.6768"/> <port id="pr_d0dd53fc-6a16-4b85-b828-b02db7a28c98_p2" x="2202.9102" y="3550.6768"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_41b8bafb-e98a-4441-a3fc-013dc5ea2783"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: FOXO3a promotes apoptosis through activation of PUMA. PMID:20978166 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1841.3147" y="3527.0908"/> <port id="pr_41b8bafb-e98a-4441-a3fc-013dc5ea2783_p1" x="1861.3147" y="3532.0908"/> <port id="pr_41b8bafb-e98a-4441-a3fc-013dc5ea2783_p2" x="1831.3147" y="3532.0908"/> </glyph> <glyph class="process" orientation="vertical" id="pr_096791e9-9248-4efb-81a7-226c5af30fa6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Cell growth arrest is induced by STAT1 through cyclin-dependent kinase inhibitor P21 WAF1/CIP1. PMID:8614832 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="94.121155" y="3226.8574"/> <port id="pr_096791e9-9248-4efb-81a7-226c5af30fa6_p1" x="99.121155" y="3216.8574"/> <port id="pr_096791e9-9248-4efb-81a7-226c5af30fa6_p2" x="99.121155" y="3246.8574"/> </glyph> <glyph class="process" orientation="vertical" id="pr_537cfb81-aebd-41d9-bbbe-49669def01a8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MAX interacts with the transcription factor C-MYC enabling C-MYC to trans-activate at least a subset of its target genes. GSK3 is constitutively active in unstimulated cells and phosphorylates many proteins (including glycogen synthase C-MYC and cyclin D) to keep them in inactive states or promote their degradation. PMID:11274345 PMID:12040186 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="3557.7812" y="3164.167"/> <port id="pr_537cfb81-aebd-41d9-bbbe-49669def01a8_p1" x="3562.7812" y="3154.167"/> <port id="pr_537cfb81-aebd-41d9-bbbe-49669def01a8_p2" x="3562.7812" y="3184.167"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_051b5b13-d6ed-4813-9685-9fadf488b08a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PDK1 is a PI3K target leading to activation of P70 and subsequent cell growth. PMID:12040186 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1536.8989" y="3557.181"/> <port id="pr_051b5b13-d6ed-4813-9685-9fadf488b08a_p1" x="1526.8989" y="3562.181"/> <port id="pr_051b5b13-d6ed-4813-9685-9fadf488b08a_p2" x="1556.8989" y="3562.181"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_17f384e5-c968-4a93-89a8-3e91f300d087"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Translation References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="108.00008" y="2898.625"/> <port id="pr_17f384e5-c968-4a93-89a8-3e91f300d087_p1" x="98.00008" y="2903.625"/> <port id="pr_17f384e5-c968-4a93-89a8-3e91f300d087_p2" x="128.00008" y="2903.625"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_4c48e96c-f4e7-433e-aeae-7319cc736076"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Cell growth arrest is induced by STAT1 through cyclin-dependent kinase inhibitor P21 WAF1/CIP1. PMID:8614832 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1753.9026" y="3244.0679"/> <port id="pr_4c48e96c-f4e7-433e-aeae-7319cc736076_p1" x="1743.9026" y="3249.0679"/> <port id="pr_4c48e96c-f4e7-433e-aeae-7319cc736076_p2" x="1773.9026" y="3249.0679"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_976c1b88-b1ef-4274-ac31-f265b7a95f3c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PKCalpha directly phosphorylates and activates Raf-1. PMID:8321321 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="1129.0105" y="2172.617"/> <port id="pr_976c1b88-b1ef-4274-ac31-f265b7a95f3c_p1" x="1119.0105" y="2177.617"/> <port id="pr_976c1b88-b1ef-4274-ac31-f265b7a95f3c_p2" x="1149.0105" y="2177.617"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_aa8bf623-7705-47b3-af08-05cdef9a7f09"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Grb2 recruits the docking protein Gab1 which is tyrosine phosphorylated by EGFR or FGFR leading to recruitment and activation of the PI3K-Akt cell survival pathway. Recruitment of PI 3-kinase by Gab1 results in a positive-feedback loop mediated by binding of the PH domain of Gab1 to the product of PI3-kinase activation phosphatidylinositol-345-triphosphate. PMID:15567848 PMID:15199124 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="836.75" y="1951.5"/> <port id="pr_aa8bf623-7705-47b3-af08-05cdef9a7f09_p1" x="856.75" y="1956.5"/> <port id="pr_aa8bf623-7705-47b3-af08-05cdef9a7f09_p2" x="826.75" y="1956.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b5a2f428-32e5-470e-8c96-126813b9d233"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: RasGRP1 activates Golgi-associated Ras on this compartment. PMID:16488589 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="315.2446" y="2226.25"/> <port id="pr_b5a2f428-32e5-470e-8c96-126813b9d233_p1" x="320.2446" y="2216.25"/> <port id="pr_b5a2f428-32e5-470e-8c96-126813b9d233_p2" x="320.2446" y="2246.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_824852b1-b6ad-4101-bb0c-ce4816c95466"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Sos is recruited from the cytosol to the plasma membrane as a result of its constitutive interaction with Grb2. It is in an autoinhibited state. PMID:17496910 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="592.7656" y="1909.0"/> <port id="pr_824852b1-b6ad-4101-bb0c-ce4816c95466_p1" x="597.7656" y="1929.0"/> <port id="pr_824852b1-b6ad-4101-bb0c-ce4816c95466_p2" x="597.7656" y="1899.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_4b0a4a13-45c7-4cb7-a712-307bd90d5f5c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Grb2 recruits the docking protein Gab1 which is tyrosine phosphorylated by EGFR or FGFR leading to recruitment and activation of the PI3K-Akt cell survival pathway. PMID:15567848 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="752.875" y="1906.9543"/> <port id="pr_4b0a4a13-45c7-4cb7-a712-307bd90d5f5c_p1" x="742.875" y="1911.9543"/> <port id="pr_4b0a4a13-45c7-4cb7-a712-307bd90d5f5c_p2" x="772.875" y="1911.9543"/> </glyph> <glyph class="process" orientation="vertical" id="pr_de87ba62-3ef9-4add-9332-97099e7ad92a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Sprouty is induced by activated ERK through phosphorylation on Tyr55. It positively regulates EGFR signalling by sequestering Cbl whereas it negatively regulates FGFR signalling by sequestering Grb2 from FSR2. PMID:15173823 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="2566.25" y="2622.0"/> <port id="pr_de87ba62-3ef9-4add-9332-97099e7ad92a_p1" x="2571.25" y="2612.0"/> <port id="pr_de87ba62-3ef9-4add-9332-97099e7ad92a_p2" x="2571.25" y="2642.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_8c1b9b4b-2582-415d-af6f-3a057abeb5d9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12040186 PMID:19568798 PMID:14585353 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4605.0" y="170.85"/> <port id="pr_8c1b9b4b-2582-415d-af6f-3a057abeb5d9_p1" x="4610.0" y="160.85"/> <port id="pr_8c1b9b4b-2582-415d-af6f-3a057abeb5d9_p2" x="4610.0" y="190.85"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_77ea9d00-0f89-497e-b15f-839e9feebda0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12040186 PMID:19568798 PMID:14585353 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4758.9414" y="267.97244"/> <port id="pr_77ea9d00-0f89-497e-b15f-839e9feebda0_p1" x="4748.9414" y="272.97244"/> <port id="pr_77ea9d00-0f89-497e-b15f-839e9feebda0_p2" x="4778.9414" y="272.97244"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2481197f-bc53-4e69-b7cb-45cd51714d03"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15534002 PMID:9779982 PMID:14585353 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5332.5" y="147.16116"/> <port id="pr_2481197f-bc53-4e69-b7cb-45cd51714d03_p1" x="5322.5" y="152.16116"/> <port id="pr_2481197f-bc53-4e69-b7cb-45cd51714d03_p2" x="5352.5" y="152.16116"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_b1900332-0df7-496a-97ad-b3b2ef1c3c88"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12040186 PMID:16288286 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5332.5" y="164.83884"/> <port id="pr_b1900332-0df7-496a-97ad-b3b2ef1c3c88_p1" x="5352.5" y="169.83884"/> <port id="pr_b1900332-0df7-496a-97ad-b3b2ef1c3c88_p2" x="5322.5" y="169.83884"/> </glyph> <glyph class="process" orientation="vertical" id="pr_258e6d83-6b96-40f8-8b9c-a237941673d5"> <bbox w="10.0" h="10.0" x="4516.4688" y="229.75"/> <port id="pr_258e6d83-6b96-40f8-8b9c-a237941673d5_p1" x="4521.4688" y="219.75"/> <port id="pr_258e6d83-6b96-40f8-8b9c-a237941673d5_p2" x="4521.4688" y="249.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1e4d6fab-daff-4b91-9fd2-a391b91a2062"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15534002 PMID:9779982 PMID:14585353 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4747.0205" y="303.8775"/> <port id="pr_1e4d6fab-daff-4b91-9fd2-a391b91a2062_p1" x="4752.0205" y="323.8775"/> <port id="pr_1e4d6fab-daff-4b91-9fd2-a391b91a2062_p2" x="4752.0205" y="293.8775"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b2e36f73-b72a-4054-ac3a-788563354f53"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18802401 PMID:17680028 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5334.452" y="228.25"/> <port id="pr_b2e36f73-b72a-4054-ac3a-788563354f53_p1" x="5339.452" y="218.25"/> <port id="pr_b2e36f73-b72a-4054-ac3a-788563354f53_p2" x="5339.452" y="248.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_83671e5c-23cc-4807-94c4-99e6935ba8e5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15584861 PMID:10648629 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6007.25" y="342.236"/> <port id="pr_83671e5c-23cc-4807-94c4-99e6935ba8e5_p1" x="6027.25" y="347.236"/> <port id="pr_83671e5c-23cc-4807-94c4-99e6935ba8e5_p2" x="5997.25" y="347.236"/> </glyph> <glyph class="process" orientation="vertical" id="pr_91564ba6-7cc9-430c-829a-a5fcdecfd1a3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19652529 PMID:19597351 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5262.25" y="698.5"/> <port id="pr_91564ba6-7cc9-430c-829a-a5fcdecfd1a3_p1" x="5267.25" y="718.5"/> <port id="pr_91564ba6-7cc9-430c-829a-a5fcdecfd1a3_p2" x="5267.25" y="688.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_553b537d-2810-420a-a25d-1f54bb3a1d88"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17218261 PMID:17218260 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5144.7812" y="836.5"/> <port id="pr_553b537d-2810-420a-a25d-1f54bb3a1d88_p1" x="5164.7812" y="841.5"/> <port id="pr_553b537d-2810-420a-a25d-1f54bb3a1d88_p2" x="5134.7812" y="841.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_738cffe1-0424-424b-8860-4150351b5144"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17218261 PMID:17218260 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4985.6562" y="991.5"/> <port id="pr_738cffe1-0424-424b-8860-4150351b5144_p1" x="4990.6562" y="981.5"/> <port id="pr_738cffe1-0424-424b-8860-4150351b5144_p2" x="4990.6562" y="1011.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_61fb46a1-4bd9-4d7a-a67c-580ead565a19"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17218261 PMID:17218260 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5237.3125" y="836.5"/> <port id="pr_61fb46a1-4bd9-4d7a-a67c-580ead565a19_p1" x="5242.3125" y="826.5"/> <port id="pr_61fb46a1-4bd9-4d7a-a67c-580ead565a19_p2" x="5242.3125" y="856.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_03a498f8-7e50-4949-ac70-8f02dd4167e7"> <bbox w="10.0" h="10.0" x="5479.0" y="239.26724"/> <port id="pr_03a498f8-7e50-4949-ac70-8f02dd4167e7_p1" x="5469.0" y="244.26724"/> <port id="pr_03a498f8-7e50-4949-ac70-8f02dd4167e7_p2" x="5499.0" y="244.26724"/> </glyph> <glyph class="process" orientation="vertical" id="pr_82d8b5cd-b92b-45a8-b74b-e5680315a8f5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:10722653 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5582.5" y="374.75"/> <port id="pr_82d8b5cd-b92b-45a8-b74b-e5680315a8f5_p1" x="5587.5" y="364.75"/> <port id="pr_82d8b5cd-b92b-45a8-b74b-e5680315a8f5_p2" x="5587.5" y="394.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c715f489-71f9-4e75-b6ee-463949308795"> <bbox w="10.0" h="10.0" x="5999.75" y="538.25"/> <port id="pr_c715f489-71f9-4e75-b6ee-463949308795_p1" x="6004.75" y="558.25"/> <port id="pr_c715f489-71f9-4e75-b6ee-463949308795_p2" x="6004.75" y="528.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_b58c079c-988c-4821-a4d2-d66e25d52ec0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18042541 PMID:18077353 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5765.375" y="389.75"/> <port id="pr_b58c079c-988c-4821-a4d2-d66e25d52ec0_p1" x="5755.375" y="394.75"/> <port id="pr_b58c079c-988c-4821-a4d2-d66e25d52ec0_p2" x="5785.375" y="394.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6804a811-c088-4d28-ae4f-f6febd7f3552"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17218261 PMID:17218260 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5207.75" y="836.5"/> <port id="pr_6804a811-c088-4d28-ae4f-f6febd7f3552_p1" x="5227.75" y="841.5"/> <port id="pr_6804a811-c088-4d28-ae4f-f6febd7f3552_p2" x="5197.75" y="841.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_0b65741c-95ad-4a69-aaa2-ef1025824be3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17218261 PMID:17218260 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5091.125" y="991.0"/> <port id="pr_0b65741c-95ad-4a69-aaa2-ef1025824be3_p1" x="5096.125" y="981.0"/> <port id="pr_0b65741c-95ad-4a69-aaa2-ef1025824be3_p2" x="5096.125" y="1011.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_79be36f1-8fe7-4ae0-ad51-da4eebe2d3d6"> <bbox w="10.0" h="10.0" x="6404.625" y="1369.25"/> <port id="pr_79be36f1-8fe7-4ae0-ad51-da4eebe2d3d6_p1" x="6394.625" y="1374.25"/> <port id="pr_79be36f1-8fe7-4ae0-ad51-da4eebe2d3d6_p2" x="6424.625" y="1374.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_cacdda45-3a5a-4730-8746-5ed81ba681a4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16636147 ANNOTATION:THE PHOSPHORYLATION STATE OF TSC2 IS NOT OFF INFLUENCE ON THE GTPase ACTIVITY OF THE PROTEIN References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6404.625" y="1349.25"/> <port id="pr_cacdda45-3a5a-4730-8746-5ed81ba681a4_p1" x="6424.625" y="1354.25"/> <port id="pr_cacdda45-3a5a-4730-8746-5ed81ba681a4_p2" x="6394.625" y="1354.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_e8f7970a-a681-4d8f-9b5d-8def3761b7ce"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19662498 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5999.125" y="607.25"/> <port id="pr_e8f7970a-a681-4d8f-9b5d-8def3761b7ce_p1" x="6004.125" y="597.25"/> <port id="pr_e8f7970a-a681-4d8f-9b5d-8def3761b7ce_p2" x="6004.125" y="627.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a902891e-099c-49db-9922-4e3aa3d50750"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19662498 PMID:19387550 PMID:18566586 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6167.0024" y="360.5"/> <port id="pr_a902891e-099c-49db-9922-4e3aa3d50750_p1" x="6172.0024" y="380.5"/> <port id="pr_a902891e-099c-49db-9922-4e3aa3d50750_p2" x="6172.0024" y="350.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_61788941-cd42-48e5-a783-6eef74021614"> <bbox w="10.0" h="10.0" x="6404.222" y="1220.0354"/> <port id="pr_61788941-cd42-48e5-a783-6eef74021614_p1" x="6394.222" y="1225.0354"/> <port id="pr_61788941-cd42-48e5-a783-6eef74021614_p2" x="6424.222" y="1225.0354"/> </glyph> <glyph class="uncertain process" orientation="horizontal" id="pr_e37b0752-bedb-4cdf-9316-cda47edd79c6"> <bbox w="10.0" h="10.0" x="5906.75" y="369.0"/> <port id="pr_e37b0752-bedb-4cdf-9316-cda47edd79c6_p1" x="5926.75" y="374.0"/> <port id="pr_e37b0752-bedb-4cdf-9316-cda47edd79c6_p2" x="5896.75" y="374.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_76dfff84-8190-423d-8f6b-92fbb4d451a0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16464865 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5771.0" y="1180.422"/> <port id="pr_76dfff84-8190-423d-8f6b-92fbb4d451a0_p1" x="5761.0" y="1185.422"/> <port id="pr_76dfff84-8190-423d-8f6b-92fbb4d451a0_p2" x="5791.0" y="1185.422"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_7f8231d3-77c6-4716-b742-d4da813b6974"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:14551205 PMID:17693255 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6243.6665" y="1205.053"/> <port id="pr_7f8231d3-77c6-4716-b742-d4da813b6974_p1" x="6233.6665" y="1210.053"/> <port id="pr_7f8231d3-77c6-4716-b742-d4da813b6974_p2" x="6263.6665" y="1210.053"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_fa963ae6-ff8f-492d-bc7b-5271b8415d23"> <bbox w="10.0" h="10.0" x="6538.222" y="1221.5511"/> <port id="pr_fa963ae6-ff8f-492d-bc7b-5271b8415d23_p1" x="6528.222" y="1226.5511"/> <port id="pr_fa963ae6-ff8f-492d-bc7b-5271b8415d23_p2" x="6558.222" y="1226.5511"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_570ca9b0-2292-4b53-98c7-31dd837b488a"> <bbox w="10.0" h="10.0" x="6230.2393" y="1717.75"/> <port id="pr_570ca9b0-2292-4b53-98c7-31dd837b488a_p1" x="6220.2393" y="1722.75"/> <port id="pr_570ca9b0-2292-4b53-98c7-31dd837b488a_p2" x="6250.2393" y="1722.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_7b389596-1a01-473e-bf43-15a7c908b158"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:10702316 PMID:19244117 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6426.08" y="1714.5"/> <port id="pr_7b389596-1a01-473e-bf43-15a7c908b158_p1" x="6416.08" y="1719.5"/> <port id="pr_7b389596-1a01-473e-bf43-15a7c908b158_p2" x="6446.08" y="1719.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_130d04ed-48cf-4569-b59b-5d9651e1f393"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19864431 PMID:12150925 PMID:15755954 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6614.42" y="1712.25"/> <port id="pr_130d04ed-48cf-4569-b59b-5d9651e1f393_p1" x="6604.42" y="1717.25"/> <port id="pr_130d04ed-48cf-4569-b59b-5d9651e1f393_p2" x="6634.42" y="1717.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_cc4449ee-76a8-41e0-96b6-1fc1e6736c7e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19864431 PMID:12150925 PMID:15755954 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6712.125" y="1860.5"/> <port id="pr_cc4449ee-76a8-41e0-96b6-1fc1e6736c7e_p1" x="6717.125" y="1850.5"/> <port id="pr_cc4449ee-76a8-41e0-96b6-1fc1e6736c7e_p2" x="6717.125" y="1880.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_b3312447-2c52-45b6-8e87-88fb2103d001"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18372248 PMID:20138985 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6583.1943" y="2011.5"/> <port id="pr_b3312447-2c52-45b6-8e87-88fb2103d001_p1" x="6603.1943" y="2016.5"/> <port id="pr_b3312447-2c52-45b6-8e87-88fb2103d001_p2" x="6573.1943" y="2016.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_bf9be23e-8fb8-4bfd-b273-781c63ca2057"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19446321 ANNOTATION:complex formation with DEPTOR antagonize/inhibits MTOR kinase activity PMID:19706736 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6339.3193" y="2011.5989"/> <port id="pr_bf9be23e-8fb8-4bfd-b273-781c63ca2057_p1" x="6359.3193" y="2016.5989"/> <port id="pr_bf9be23e-8fb8-4bfd-b273-781c63ca2057_p2" x="6329.3193" y="2016.5989"/> </glyph> <glyph class="process" orientation="vertical" id="pr_7087eaa7-068e-44d2-9c8a-7cd6745c0e05"> <bbox w="10.0" h="10.0" x="6067.854" y="2148.25"/> <port id="pr_7087eaa7-068e-44d2-9c8a-7cd6745c0e05_p1" x="6072.854" y="2168.25"/> <port id="pr_7087eaa7-068e-44d2-9c8a-7cd6745c0e05_p2" x="6072.854" y="2138.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_7013a741-0f66-45d7-a63b-ef88ce4695dd"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17604271 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6134.0" y="2183.3906"/> <port id="pr_7013a741-0f66-45d7-a63b-ef88ce4695dd_p1" x="6154.0" y="2188.3906"/> <port id="pr_7013a741-0f66-45d7-a63b-ef88ce4695dd_p2" x="6124.0" y="2188.3906"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9dd36598-c1b0-423b-ad85-0da2ebc82b93"> <bbox w="10.0" h="10.0" x="5472.144" y="1567.75"/> <port id="pr_9dd36598-c1b0-423b-ad85-0da2ebc82b93_p1" x="5492.144" y="1572.75"/> <port id="pr_9dd36598-c1b0-423b-ad85-0da2ebc82b93_p2" x="5462.144" y="1572.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a7cc3574-fdee-42ce-a4b6-b70e08f1ef5c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16286006 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4649.6445" y="1218.5859"/> <port id="pr_a7cc3574-fdee-42ce-a4b6-b70e08f1ef5c_p1" x="4654.6445" y="1208.5859"/> <port id="pr_a7cc3574-fdee-42ce-a4b6-b70e08f1ef5c_p2" x="4654.6445" y="1238.5859"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1998b608-119d-486c-b426-d163f4091e48"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16286006 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4646.34" y="1508.5"/> <port id="pr_1998b608-119d-486c-b426-d163f4091e48_p1" x="4651.34" y="1498.5"/> <port id="pr_1998b608-119d-486c-b426-d163f4091e48_p2" x="4651.34" y="1528.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5aff70c5-0f71-4a57-b027-fdb503a6eb98"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16286006 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5099.75" y="1632.5"/> <port id="pr_5aff70c5-0f71-4a57-b027-fdb503a6eb98_p1" x="5104.75" y="1622.5"/> <port id="pr_5aff70c5-0f71-4a57-b027-fdb503a6eb98_p2" x="5104.75" y="1652.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1dadef62-12bf-410d-a5f7-da3276e58cce"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16286006 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4934.75" y="1683.75"/> <port id="pr_1dadef62-12bf-410d-a5f7-da3276e58cce_p1" x="4939.75" y="1673.75"/> <port id="pr_1dadef62-12bf-410d-a5f7-da3276e58cce_p2" x="4939.75" y="1703.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_e731fac3-c7d2-46a2-a860-4d2a6ffc00bf"> <bbox w="10.0" h="10.0" x="5257.75" y="1635.5"/> <port id="pr_e731fac3-c7d2-46a2-a860-4d2a6ffc00bf_p1" x="5262.75" y="1625.5"/> <port id="pr_e731fac3-c7d2-46a2-a860-4d2a6ffc00bf_p2" x="5262.75" y="1655.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c621aa31-0224-4c58-ba7d-5f551e7e8904"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21233202 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5265.25" y="1798.0"/> <port id="pr_c621aa31-0224-4c58-ba7d-5f551e7e8904_p1" x="5270.25" y="1788.0"/> <port id="pr_c621aa31-0224-4c58-ba7d-5f551e7e8904_p2" x="5270.25" y="1818.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_17677eeb-d39a-4878-be53-e64f3dc67202"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21233202 PMID:12713446 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5108.875" y="1848.0"/> <port id="pr_17677eeb-d39a-4878-be53-e64f3dc67202_p1" x="5128.875" y="1853.0"/> <port id="pr_17677eeb-d39a-4878-be53-e64f3dc67202_p2" x="5098.875" y="1853.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_80dc5877-a9df-4341-8dfa-eb15844271e1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17053147 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5259.75" y="2057.5"/> <port id="pr_80dc5877-a9df-4341-8dfa-eb15844271e1_p1" x="5249.75" y="2062.5"/> <port id="pr_80dc5877-a9df-4341-8dfa-eb15844271e1_p2" x="5279.75" y="2062.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_237f86ca-16aa-4a14-b777-65bdfe8420b5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17053147 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5358.7812" y="2164.0"/> <port id="pr_237f86ca-16aa-4a14-b777-65bdfe8420b5_p1" x="5363.7812" y="2154.0"/> <port id="pr_237f86ca-16aa-4a14-b777-65bdfe8420b5_p2" x="5363.7812" y="2184.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a614b87b-407f-46f2-a94d-9340b01a5725"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17053147 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5485.0" y="2132.75"/> <port id="pr_a614b87b-407f-46f2-a94d-9340b01a5725_p1" x="5490.0" y="2152.75"/> <port id="pr_a614b87b-407f-46f2-a94d-9340b01a5725_p2" x="5490.0" y="2122.75"/> </glyph> <glyph class="and" orientation="vertical" id="logicglyph_49c9e617-3cb5-41f0-adb2-6b8f188c6ffd"> <bbox w="20.0" h="20.0" x="5622.0225" y="1366.2623"/> <port id="logicglyph_49c9e617-3cb5-41f0-adb2-6b8f188c6ffd_p1" x="5632.0225" y="1356.2623"/> <port id="logicglyph_49c9e617-3cb5-41f0-adb2-6b8f188c6ffd_p2" x="5632.0225" y="1396.2623"/> </glyph> <glyph class="process" orientation="vertical" id="pr_6dfaa30b-4e4e-48c8-9c07-8573e69ab3a8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16286006 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4641.7197" y="1910.5"/> <port id="pr_6dfaa30b-4e4e-48c8-9c07-8573e69ab3a8_p1" x="4646.7197" y="1900.5"/> <port id="pr_6dfaa30b-4e4e-48c8-9c07-8573e69ab3a8_p2" x="4646.7197" y="1930.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_cbe73549-d7e7-4819-9810-9b74db6ad39f"> <bbox w="10.0" h="10.0" x="4638.25" y="2291.75"/> <port id="pr_cbe73549-d7e7-4819-9810-9b74db6ad39f_p1" x="4643.25" y="2281.75"/> <port id="pr_cbe73549-d7e7-4819-9810-9b74db6ad39f_p2" x="4643.25" y="2311.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6c2068c6-426c-4116-8fc5-f173846e567b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18423201 PMID:19339977 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5062.25" y="2295.0"/> <port id="pr_6c2068c6-426c-4116-8fc5-f173846e567b_p1" x="5082.25" y="2300.0"/> <port id="pr_6c2068c6-426c-4116-8fc5-f173846e567b_p2" x="5052.25" y="2300.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_52eabbb7-e000-4be9-8492-89d0e4c93257"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18423201 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4757.5" y="2319.0"/> <port id="pr_52eabbb7-e000-4be9-8492-89d0e4c93257_p1" x="4777.5" y="2324.0"/> <port id="pr_52eabbb7-e000-4be9-8492-89d0e4c93257_p2" x="4747.5" y="2324.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a2b224be-d446-4abb-b90b-61afa117b8a6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17444818 ANNOTATION:PTEN is destabilized by phosphorylation on T366 followed by phosphorylation on S370 by GSK3beta. References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5358.75" y="757.0"/> <port id="pr_a2b224be-d446-4abb-b90b-61afa117b8a6_p1" x="5348.75" y="762.0"/> <port id="pr_a2b224be-d446-4abb-b90b-61afa117b8a6_p2" x="5378.75" y="762.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_05bed02e-1abf-451c-9e0f-314179812cb0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17444818 ANNOTATION:PTEN is destabilized by phosphorylation on T366 followed by phosphorylation on S370 by GSK3beta. References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5529.25" y="757.0"/> <port id="pr_05bed02e-1abf-451c-9e0f-314179812cb0_p1" x="5519.25" y="762.0"/> <port id="pr_05bed02e-1abf-451c-9e0f-314179812cb0_p2" x="5549.25" y="762.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_b3f46093-b859-4d23-8b96-62e06bdd6c63"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20338997 PMID:18570873 PMID:18925875 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4712.8125" y="917.0"/> <port id="pr_b3f46093-b859-4d23-8b96-62e06bdd6c63_p1" x="4702.8125" y="922.0"/> <port id="pr_b3f46093-b859-4d23-8b96-62e06bdd6c63_p2" x="4732.8125" y="922.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_bfa8694a-5e9c-4d8b-b65a-93351c02a69a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11500365 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4841.375" y="917.0"/> <port id="pr_bfa8694a-5e9c-4d8b-b65a-93351c02a69a_p1" x="4831.375" y="922.0"/> <port id="pr_bfa8694a-5e9c-4d8b-b65a-93351c02a69a_p2" x="4861.375" y="922.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9368ecca-fc17-4f61-93ce-aadce0c2cef2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19720745 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5080.0" y="493.875"/> <port id="pr_9368ecca-fc17-4f61-93ce-aadce0c2cef2_p1" x="5100.0" y="498.875"/> <port id="pr_9368ecca-fc17-4f61-93ce-aadce0c2cef2_p2" x="5070.0" y="498.875"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_389940de-9e6e-4e0d-a52b-299312c1b817"> <bbox w="10.0" h="10.0" x="4860.9375" y="491.22107"/> <port id="pr_389940de-9e6e-4e0d-a52b-299312c1b817_p1" x="4880.9375" y="496.22107"/> <port id="pr_389940de-9e6e-4e0d-a52b-299312c1b817_p2" x="4850.9375" y="496.22107"/> </glyph> <glyph class="process" orientation="vertical" id="pr_cfb860ce-b5e8-4ea3-885d-a957797df07a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18570873 PMID:18636226 p27 is phosphorylated by Akt RSK1 and RSK2 in early G1 phase References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5593.0" y="981.8069"/> <port id="pr_cfb860ce-b5e8-4ea3-885d-a957797df07a_p1" x="5598.0" y="971.8069"/> <port id="pr_cfb860ce-b5e8-4ea3-885d-a957797df07a_p2" x="5598.0" y="1001.8069"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b97f11e4-200a-48f8-bbfc-ddefde05fd7a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19887899 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5523.7407" y="1089.0"/> <port id="pr_b97f11e4-200a-48f8-bbfc-ddefde05fd7a_p1" x="5528.7407" y="1079.0"/> <port id="pr_b97f11e4-200a-48f8-bbfc-ddefde05fd7a_p2" x="5528.7407" y="1109.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_296706c7-5a20-40f3-87eb-826469701e53"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19887899 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5611.591" y="1199.5"/> <port id="pr_296706c7-5a20-40f3-87eb-826469701e53_p1" x="5616.591" y="1189.5"/> <port id="pr_296706c7-5a20-40f3-87eb-826469701e53_p2" x="5616.591" y="1219.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_70063ad8-47ff-41da-9ee0-2c40eb1803f4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11154281 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5095.0" y="1175.0"/> <port id="pr_70063ad8-47ff-41da-9ee0-2c40eb1803f4_p1" x="5100.0" y="1195.0"/> <port id="pr_70063ad8-47ff-41da-9ee0-2c40eb1803f4_p2" x="5100.0" y="1165.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_dd65b2ed-4124-4f9b-83b4-cb110c379e0b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11154281 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5041.3125" y="1062.0"/> <port id="pr_dd65b2ed-4124-4f9b-83b4-cb110c379e0b_p1" x="5031.3125" y="1067.0"/> <port id="pr_dd65b2ed-4124-4f9b-83b4-cb110c379e0b_p2" x="5061.3125" y="1067.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_af0a9bed-5788-46a6-9978-def06b67560b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11154281 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5101.0" y="1102.5"/> <port id="pr_af0a9bed-5788-46a6-9978-def06b67560b_p1" x="5106.0" y="1122.5"/> <port id="pr_af0a9bed-5788-46a6-9978-def06b67560b_p2" x="5106.0" y="1092.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_29696afa-e793-4b7f-88a2-a720de07cad1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11154281 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5199.0" y="1131.7693"/> <port id="pr_29696afa-e793-4b7f-88a2-a720de07cad1_p1" x="5189.0" y="1136.7693"/> <port id="pr_29696afa-e793-4b7f-88a2-a720de07cad1_p2" x="5219.0" y="1136.7693"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c6342a74-ceef-4bea-a68a-3b250a8a5d58"> <bbox w="10.0" h="10.0" x="5373.75" y="994.0"/> <port id="pr_c6342a74-ceef-4bea-a68a-3b250a8a5d58_p1" x="5363.75" y="999.0"/> <port id="pr_c6342a74-ceef-4bea-a68a-3b250a8a5d58_p2" x="5393.75" y="999.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_94f75e88-b38e-4e31-9efe-b45d69024262"> <bbox w="10.0" h="10.0" x="5460.75" y="824.5"/> <port id="pr_94f75e88-b38e-4e31-9efe-b45d69024262_p1" x="5465.75" y="814.5"/> <port id="pr_94f75e88-b38e-4e31-9efe-b45d69024262_p2" x="5465.75" y="844.5"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_62123742-f386-42ae-9dbf-a6a3a722b7f0"> <bbox w="10.0" h="10.0" x="5089.0" y="1272.0"/> <port id="pr_62123742-f386-42ae-9dbf-a6a3a722b7f0_p1" x="5079.0" y="1277.0"/> <port id="pr_62123742-f386-42ae-9dbf-a6a3a722b7f0_p2" x="5109.0" y="1277.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_5f861ffe-999a-4377-8f9e-fcfacb9c3ab7"> <bbox w="10.0" h="10.0" x="5357.75" y="1272.0"/> <port id="pr_5f861ffe-999a-4377-8f9e-fcfacb9c3ab7_p1" x="5347.75" y="1277.0"/> <port id="pr_5f861ffe-999a-4377-8f9e-fcfacb9c3ab7_p2" x="5377.75" y="1277.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_b968dc20-6c64-45a4-aa56-28c1cf673b6c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15905173 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5655.5312" y="1705.5781"/> <port id="pr_b968dc20-6c64-45a4-aa56-28c1cf673b6c_p1" x="5645.5312" y="1710.5781"/> <port id="pr_b968dc20-6c64-45a4-aa56-28c1cf673b6c_p2" x="5675.5312" y="1710.5781"/> </glyph> <glyph class="process" orientation="vertical" id="pr_497c0619-a7f0-4646-bc48-b86314fb9dc8"> <bbox w="10.0" h="10.0" x="5767.3735" y="1691.5"/> <port id="pr_497c0619-a7f0-4646-bc48-b86314fb9dc8_p1" x="5772.3735" y="1681.5"/> <port id="pr_497c0619-a7f0-4646-bc48-b86314fb9dc8_p2" x="5772.3735" y="1711.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_bf98526d-d4ba-40b9-9a34-893bb816b50d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21474067 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5473.875" y="1698.2566"/> <port id="pr_bf98526d-d4ba-40b9-9a34-893bb816b50d_p1" x="5493.875" y="1703.2566"/> <port id="pr_bf98526d-d4ba-40b9-9a34-893bb816b50d_p2" x="5463.875" y="1703.2566"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_06701cc3-0232-493c-b2de-f3f030594177"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17052453 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6065.75" y="376.0"/> <port id="pr_06701cc3-0232-493c-b2de-f3f030594177_p1" x="6055.75" y="381.0"/> <port id="pr_06701cc3-0232-493c-b2de-f3f030594177_p2" x="6085.75" y="381.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ec44a390-e815-400c-bf85-321c8dfc619d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:12791379 PMID:10582334 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5524.5" y="156.0"/> <port id="pr_ec44a390-e815-400c-bf85-321c8dfc619d_p1" x="5514.5" y="161.0"/> <port id="pr_ec44a390-e815-400c-bf85-321c8dfc619d_p2" x="5544.5" y="161.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c9dd76b6-010e-4cdd-84e5-892e95d03723"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15808505 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5532.5" y="374.75"/> <port id="pr_c9dd76b6-010e-4cdd-84e5-892e95d03723_p1" x="5537.5" y="394.75"/> <port id="pr_c9dd76b6-010e-4cdd-84e5-892e95d03723_p2" x="5537.5" y="364.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_f8a1a8e5-7aff-4ddc-b18a-a23fc34826ae"> <bbox w="10.0" h="10.0" x="5303.508" y="480.9375"/> <port id="pr_f8a1a8e5-7aff-4ddc-b18a-a23fc34826ae_p1" x="5308.508" y="500.9375"/> <port id="pr_f8a1a8e5-7aff-4ddc-b18a-a23fc34826ae_p2" x="5308.508" y="470.9375"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_81d266b9-ba66-4a50-a86d-373a509a39e3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15169778 PMID:11923280 PMID:11715018 PMID:16697215 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4956.5" y="980.0"/> <port id="pr_81d266b9-ba66-4a50-a86d-373a509a39e3_p1" x="4976.5" y="985.0"/> <port id="pr_81d266b9-ba66-4a50-a86d-373a509a39e3_p2" x="4946.5" y="985.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_e5776425-d273-492d-b86d-aafc5e87ab65"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15169778 PMID:11923280 PMID:11715018 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5224.5" y="1420.0"/> <port id="pr_e5776425-d273-492d-b86d-aafc5e87ab65_p1" x="5229.5" y="1410.0"/> <port id="pr_e5776425-d273-492d-b86d-aafc5e87ab65_p2" x="5229.5" y="1440.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_8ef3b96a-d40e-4667-a605-8b7661dd839e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:15169778 PMID:11923280 PMID:11715018 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5056.25" y="1179.5"/> <port id="pr_8ef3b96a-d40e-4667-a605-8b7661dd839e_p1" x="5061.25" y="1169.5"/> <port id="pr_8ef3b96a-d40e-4667-a605-8b7661dd839e_p2" x="5061.25" y="1199.5"/> </glyph> <glyph class="omitted process" orientation="vertical" id="pr_dca281c7-28fb-403c-af28-e0320a56a2da"> <bbox w="10.0" h="10.0" x="6601.0" y="835.5"/> <port id="pr_dca281c7-28fb-403c-af28-e0320a56a2da_p1" x="6606.0" y="825.5"/> <port id="pr_dca281c7-28fb-403c-af28-e0320a56a2da_p2" x="6606.0" y="855.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_b20cb6c2-c0f9-4c4a-a96a-cf73b89dae30"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:10949026 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6659.25" y="762.0"/> <port id="pr_b20cb6c2-c0f9-4c4a-a96a-cf73b89dae30_p1" x="6649.25" y="767.0"/> <port id="pr_b20cb6c2-c0f9-4c4a-a96a-cf73b89dae30_p2" x="6679.25" y="767.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_379a6f52-f432-449f-a3b5-79b0e18b8463"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:10949026 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6568.5" y="755.0"/> <port id="pr_379a6f52-f432-449f-a3b5-79b0e18b8463_p1" x="6558.5" y="760.0"/> <port id="pr_379a6f52-f432-449f-a3b5-79b0e18b8463_p2" x="6588.5" y="760.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_fa8b1b5f-b50e-4ebf-9a96-cded37732192"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:10949026 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6674.658" y="873.1875"/> <port id="pr_fa8b1b5f-b50e-4ebf-9a96-cded37732192_p1" x="6679.658" y="863.1875"/> <port id="pr_fa8b1b5f-b50e-4ebf-9a96-cded37732192_p2" x="6679.658" y="893.1875"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_572ea306-b98d-452c-b420-6f8ef21c3021"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:10949026 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6643.75" y="974.25"/> <port id="pr_572ea306-b98d-452c-b420-6f8ef21c3021_p1" x="6663.75" y="979.25"/> <port id="pr_572ea306-b98d-452c-b420-6f8ef21c3021_p2" x="6633.75" y="979.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_52e548a2-ab70-4d63-9709-b8a64c9067ea"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:10949026 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6510.75" y="880.96606"/> <port id="pr_52e548a2-ab70-4d63-9709-b8a64c9067ea_p1" x="6530.75" y="885.96606"/> <port id="pr_52e548a2-ab70-4d63-9709-b8a64c9067ea_p2" x="6500.75" y="885.96606"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_578d072e-d740-4634-a235-9b0d4c6ef9ba"> <bbox w="10.0" h="10.0" x="6397.25" y="914.0"/> <port id="pr_578d072e-d740-4634-a235-9b0d4c6ef9ba_p1" x="6417.25" y="919.0"/> <port id="pr_578d072e-d740-4634-a235-9b0d4c6ef9ba_p2" x="6387.25" y="919.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_9e451660-3b20-418d-8827-ad8497f817a5"> <bbox w="10.0" h="10.0" x="6218.0" y="438.0"/> <port id="pr_9e451660-3b20-418d-8827-ad8497f817a5_p1" x="6223.0" y="428.0"/> <port id="pr_9e451660-3b20-418d-8827-ad8497f817a5_p2" x="6223.0" y="458.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_88c0c3e0-d499-49fb-9aa7-5c5dbbbbd74c"> <bbox w="10.0" h="10.0" x="6299.0" y="477.625"/> <port id="pr_88c0c3e0-d499-49fb-9aa7-5c5dbbbbd74c_p1" x="6289.0" y="482.625"/> <port id="pr_88c0c3e0-d499-49fb-9aa7-5c5dbbbbd74c_p2" x="6319.0" y="482.625"/> </glyph> <glyph class="omitted process" orientation="vertical" id="pr_9d0ba892-1c84-444a-98af-9f189925b340"> <bbox w="10.0" h="10.0" x="6473.25" y="752.0"/> <port id="pr_9d0ba892-1c84-444a-98af-9f189925b340_p1" x="6478.25" y="772.0"/> <port id="pr_9d0ba892-1c84-444a-98af-9f189925b340_p2" x="6478.25" y="742.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_fa5e165d-912d-4c75-adb9-c692253b8206"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19788417 PMID:16977332 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6172.5" y="842.0"/> <port id="pr_fa5e165d-912d-4c75-adb9-c692253b8206_p1" x="6162.5" y="847.0"/> <port id="pr_fa5e165d-912d-4c75-adb9-c692253b8206_p2" x="6192.5" y="847.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ba9253ca-21c1-4a54-9c37-865dca0e2c7e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:9812896 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6195.75" y="782.5"/> <port id="pr_ba9253ca-21c1-4a54-9c37-865dca0e2c7e_p1" x="6185.75" y="787.5"/> <port id="pr_ba9253ca-21c1-4a54-9c37-865dca0e2c7e_p2" x="6215.75" y="787.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5d8e40bc-911b-4c5d-af10-7089fc436beb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:10514377 PMID:17635922 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6483.75" y="677.0"/> <port id="pr_5d8e40bc-911b-4c5d-af10-7089fc436beb_p1" x="6503.75" y="682.0"/> <port id="pr_5d8e40bc-911b-4c5d-af10-7089fc436beb_p2" x="6473.75" y="682.0"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_37b44088-a37b-418e-ab66-c167262475c3"> <bbox w="20.0" h="20.0" x="6160.75" y="725.5"/> <port id="logicglyph_37b44088-a37b-418e-ab66-c167262475c3_p1" x="6150.75" y="735.5"/> <port id="logicglyph_37b44088-a37b-418e-ab66-c167262475c3_p2" x="6190.75" y="735.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_d8f60db8-9000-4464-a5fc-25687f8d261a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:10514377 PMID:17635922 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6439.625" y="553.75"/> <port id="pr_d8f60db8-9000-4464-a5fc-25687f8d261a_p1" x="6444.625" y="543.75"/> <port id="pr_d8f60db8-9000-4464-a5fc-25687f8d261a_p2" x="6444.625" y="573.75"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_a0d2c798-b869-4f13-b1f8-bfe1dae0542a"> <bbox w="20.0" h="20.0" x="6031.0" y="701.75"/> <port id="logicglyph_a0d2c798-b869-4f13-b1f8-bfe1dae0542a_p1" x="6021.0" y="711.75"/> <port id="logicglyph_a0d2c798-b869-4f13-b1f8-bfe1dae0542a_p2" x="6061.0" y="711.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_e7f2d0cb-2827-440c-8f69-964845a4eae6"> <bbox w="10.0" h="10.0" x="5632.375" y="281.0"/> <port id="pr_e7f2d0cb-2827-440c-8f69-964845a4eae6_p1" x="5622.375" y="286.0"/> <port id="pr_e7f2d0cb-2827-440c-8f69-964845a4eae6_p2" x="5652.375" y="286.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2e041e5c-d761-4d91-b289-f4c9959ffdd7"> <bbox w="10.0" h="10.0" x="6195.75" y="363.0"/> <port id="pr_2e041e5c-d761-4d91-b289-f4c9959ffdd7_p1" x="6185.75" y="368.0"/> <port id="pr_2e041e5c-d761-4d91-b289-f4c9959ffdd7_p2" x="6215.75" y="368.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_680f3ad9-da89-45ef-99c7-a570bb1d30ca"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11313945 PMID:11940581 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6302.75" y="544.5"/> <port id="pr_680f3ad9-da89-45ef-99c7-a570bb1d30ca_p1" x="6292.75" y="549.5"/> <port id="pr_680f3ad9-da89-45ef-99c7-a570bb1d30ca_p2" x="6322.75" y="549.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_61785acd-8f0f-4330-9bf9-51b870ffc063"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11707428 phospho- rylation of the PTEN tail negatively regulates PTEN activity PMID:11035045 phosphorylation of PTEN by CK2 is important for PTEN protein stability to proteasome-mediated degradation References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5312.125" y="836.5"/> <port id="pr_61785acd-8f0f-4330-9bf9-51b870ffc063_p1" x="5317.125" y="826.5"/> <port id="pr_61785acd-8f0f-4330-9bf9-51b870ffc063_p2" x="5317.125" y="856.5"/> </glyph> <glyph class="omitted process" orientation="vertical" id="pr_4b55ef54-be05-405e-8ec4-42af90d36ea7"> <bbox w="10.0" h="10.0" x="4962.5137" y="1137.6111"/> <port id="pr_4b55ef54-be05-405e-8ec4-42af90d36ea7_p1" x="4967.5137" y="1127.6111"/> <port id="pr_4b55ef54-be05-405e-8ec4-42af90d36ea7_p2" x="4967.5137" y="1157.6111"/> </glyph> <glyph class="omitted process" orientation="vertical" id="pr_a1ccd50d-fc88-4dad-b49f-8e081fd86951"> <bbox w="10.0" h="10.0" x="5015.0137" y="1137.1111"/> <port id="pr_a1ccd50d-fc88-4dad-b49f-8e081fd86951_p1" x="5020.0137" y="1127.1111"/> <port id="pr_a1ccd50d-fc88-4dad-b49f-8e081fd86951_p2" x="5020.0137" y="1157.1111"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a741082e-2bdc-4014-ad53-769c03f1b3d1"> <bbox w="10.0" h="10.0" x="4892.0137" y="1361.1111"/> <port id="pr_a741082e-2bdc-4014-ad53-769c03f1b3d1_p1" x="4897.0137" y="1351.1111"/> <port id="pr_a741082e-2bdc-4014-ad53-769c03f1b3d1_p2" x="4897.0137" y="1381.1111"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2d7c674e-f0a7-446e-8809-2f21fb10c12f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19797085 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6075.0" y="749.0"/> <port id="pr_2d7c674e-f0a7-446e-8809-2f21fb10c12f_p1" x="6065.0" y="754.0"/> <port id="pr_2d7c674e-f0a7-446e-8809-2f21fb10c12f_p2" x="6095.0" y="754.0"/> </glyph> <glyph class="and" orientation="vertical" id="logicglyph_6d6cb4a6-997b-4bb7-bf33-6a611457d8fe"> <bbox w="20.0" h="20.0" x="5980.25" y="620.005"/> <port id="logicglyph_6d6cb4a6-997b-4bb7-bf33-6a611457d8fe_p1" x="5990.25" y="610.005"/> <port id="logicglyph_6d6cb4a6-997b-4bb7-bf33-6a611457d8fe_p2" x="5990.25" y="650.005"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d22f47af-5195-47d3-8c8d-25176953c476"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19797085 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5777.875" y="749.0"/> <port id="pr_d22f47af-5195-47d3-8c8d-25176953c476_p1" x="5767.875" y="754.0"/> <port id="pr_d22f47af-5195-47d3-8c8d-25176953c476_p2" x="5797.875" y="754.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9e474693-08a8-46b4-a736-98e6c3ce4ed2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19797085 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5915.125" y="749.0"/> <port id="pr_9e474693-08a8-46b4-a736-98e6c3ce4ed2_p1" x="5905.125" y="754.0"/> <port id="pr_9e474693-08a8-46b4-a736-98e6c3ce4ed2_p2" x="5935.125" y="754.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_a3e542d9-b1e3-44d8-96e3-87da65d8f90d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21177869 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5013.0" y="1434.0"/> <port id="pr_a3e542d9-b1e3-44d8-96e3-87da65d8f90d_p1" x="5003.0" y="1439.0"/> <port id="pr_a3e542d9-b1e3-44d8-96e3-87da65d8f90d_p2" x="5033.0" y="1439.0"/> </glyph> <glyph class="omitted process" orientation="vertical" id="pr_8d246134-d47b-439c-9cea-441097b079a5"> <bbox w="10.0" h="10.0" x="5412.7153" y="1095.25"/> <port id="pr_8d246134-d47b-439c-9cea-441097b079a5_p1" x="5417.7153" y="1115.25"/> <port id="pr_8d246134-d47b-439c-9cea-441097b079a5_p2" x="5417.7153" y="1085.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_fc0e36ac-036c-40fe-9864-89cad55ea0b0"> <bbox w="10.0" h="10.0" x="5972.25" y="2293.75"/> <port id="pr_fc0e36ac-036c-40fe-9864-89cad55ea0b0_p1" x="5977.25" y="2283.75"/> <port id="pr_fc0e36ac-036c-40fe-9864-89cad55ea0b0_p2" x="5977.25" y="2313.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6faba24b-d620-48e3-a426-ceae4fdce7c2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16636147 Phosphorylation of S939 and S981 by Akt initiates binding of 14-3-3 protein to TSC2 leading to trans References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6680.0" y="1394.0"/> <port id="pr_6faba24b-d620-48e3-a426-ceae4fdce7c2_p1" x="6670.0" y="1399.0"/> <port id="pr_6faba24b-d620-48e3-a426-ceae4fdce7c2_p2" x="6700.0" y="1399.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_09bded0f-76c2-444d-bf0d-35baf07eae56"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16636147 Phosphorylation of S939 and S981 by Akt initiates binding of 14-3-3 protein to TSC2 leading to trans References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6617.1113" y="1319.3668"/> <port id="pr_09bded0f-76c2-444d-bf0d-35baf07eae56_p1" x="6637.1113" y="1324.3668"/> <port id="pr_09bded0f-76c2-444d-bf0d-35baf07eae56_p2" x="6607.1113" y="1324.3668"/> </glyph> <glyph class="process" orientation="vertical" id="pr_86e61fa7-af9c-4b94-b3f7-c3f71d48b13a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:14551205 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6152.5522" y="1260.9148"/> <port id="pr_86e61fa7-af9c-4b94-b3f7-c3f71d48b13a_p1" x="6157.5522" y="1280.9148"/> <port id="pr_86e61fa7-af9c-4b94-b3f7-c3f71d48b13a_p2" x="6157.5522" y="1250.9148"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6f32f130-225a-4776-a429-7d5b7b102927"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17693255 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6151.5522" y="1297.2677"/> <port id="pr_6f32f130-225a-4776-a429-7d5b7b102927_p1" x="6171.5522" y="1302.2677"/> <port id="pr_6f32f130-225a-4776-a429-7d5b7b102927_p2" x="6141.5522" y="1302.2677"/> </glyph> <glyph class="process" orientation="vertical" id="pr_846b0ca2-b6b2-4c5e-81d6-05951e09407f"> <bbox w="10.0" h="10.0" x="5070.0" y="489.25"/> <port id="pr_846b0ca2-b6b2-4c5e-81d6-05951e09407f_p1" x="5075.0" y="509.25"/> <port id="pr_846b0ca2-b6b2-4c5e-81d6-05951e09407f_p2" x="5075.0" y="479.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_226643fb-64ed-48f4-81fa-fc20b6caa3ca"> <bbox w="10.0" h="10.0" x="4633.0" y="481.6875"/> <port id="pr_226643fb-64ed-48f4-81fa-fc20b6caa3ca_p1" x="4653.0" y="486.6875"/> <port id="pr_226643fb-64ed-48f4-81fa-fc20b6caa3ca_p2" x="4623.0" y="486.6875"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_1118b70b-00c0-42da-80e6-a887a66c3b74"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20027184 PMID:21474067 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4847.667" y="608.9375"/> <port id="pr_1118b70b-00c0-42da-80e6-a887a66c3b74_p1" x="4837.667" y="613.9375"/> <port id="pr_1118b70b-00c0-42da-80e6-a887a66c3b74_p2" x="4867.667" y="613.9375"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_87fc2750-cb1a-4976-b58e-dbf034b2a38b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18851840 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4714.75" y="348.5"/> <port id="pr_87fc2750-cb1a-4976-b58e-dbf034b2a38b_p1" x="4704.75" y="353.5"/> <port id="pr_87fc2750-cb1a-4976-b58e-dbf034b2a38b_p2" x="4734.75" y="353.5"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_82402bcd-6806-4031-bd62-573bbb8299da"> <bbox w="10.0" h="10.0" x="6412.5" y="847.5"/> <port id="pr_82402bcd-6806-4031-bd62-573bbb8299da_p1" x="6402.5" y="852.5"/> <port id="pr_82402bcd-6806-4031-bd62-573bbb8299da_p2" x="6432.5" y="852.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2fcc6320-b2e7-48cb-83c6-6d1bc7768826"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20709625 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6257.0" y="1064.0"/> <port id="pr_2fcc6320-b2e7-48cb-83c6-6d1bc7768826_p1" x="6277.0" y="1069.0"/> <port id="pr_2fcc6320-b2e7-48cb-83c6-6d1bc7768826_p2" x="6247.0" y="1069.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ed573d86-5ddc-47ab-b66e-4f319542e1ef"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19788417 PMID:16977332 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6061.1597" y="938.0"/> <port id="pr_ed573d86-5ddc-47ab-b66e-4f319542e1ef_p1" x="6066.1597" y="928.0"/> <port id="pr_ed573d86-5ddc-47ab-b66e-4f319542e1ef_p2" x="6066.1597" y="958.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_008aa880-1103-497b-8ca5-a15fc55f12c4"> <bbox w="10.0" h="10.0" x="6025.5" y="953.5"/> <port id="pr_008aa880-1103-497b-8ca5-a15fc55f12c4_p1" x="6015.5" y="958.5"/> <port id="pr_008aa880-1103-497b-8ca5-a15fc55f12c4_p2" x="6045.5" y="958.5"/> </glyph> <glyph class="and" orientation="vertical" id="logicglyph_ca4d9fd6-14b2-4456-87d5-904718ee152c"> <bbox w="20.0" h="20.0" x="5947.0" y="1030.3333"/> <port id="logicglyph_ca4d9fd6-14b2-4456-87d5-904718ee152c_p1" x="5957.0" y="1060.3333"/> <port id="logicglyph_ca4d9fd6-14b2-4456-87d5-904718ee152c_p2" x="5957.0" y="1020.33325"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8a5c5102-8585-42f1-8aa8-a285a7a6c0d4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18308511 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6030.25" y="1020.5"/> <port id="pr_8a5c5102-8585-42f1-8aa8-a285a7a6c0d4_p1" x="6020.25" y="1025.5"/> <port id="pr_8a5c5102-8585-42f1-8aa8-a285a7a6c0d4_p2" x="6050.25" y="1025.5"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_f742ebf3-0c35-46c6-9e22-1c64873b8622"> <bbox w="20.0" h="20.0" x="5944.3335" y="1048.3333"/> <port id="logicglyph_f742ebf3-0c35-46c6-9e22-1c64873b8622_p1" x="5934.3335" y="1058.3333"/> <port id="logicglyph_f742ebf3-0c35-46c6-9e22-1c64873b8622_p2" x="5974.3335" y="1058.3333"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ff4b854a-5c9d-4a21-944a-afab5c8866cb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18298802 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6036.5" y="1085.5"/> <port id="pr_ff4b854a-5c9d-4a21-944a-afab5c8866cb_p1" x="6026.5" y="1090.5"/> <port id="pr_ff4b854a-5c9d-4a21-944a-afab5c8866cb_p2" x="6056.5" y="1090.5"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_52ad000e-fd1f-4d92-90d3-752ca0d1df89"> <bbox w="20.0" h="20.0" x="5946.3335" y="1071.0"/> <port id="logicglyph_52ad000e-fd1f-4d92-90d3-752ca0d1df89_p1" x="5936.3335" y="1081.0"/> <port id="logicglyph_52ad000e-fd1f-4d92-90d3-752ca0d1df89_p2" x="5976.3335" y="1081.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ae437c92-1aac-4587-8621-9087cb4eb946"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18381890 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6120.25" y="1050.5"/> <port id="pr_ae437c92-1aac-4587-8621-9087cb4eb946_p1" x="6125.25" y="1070.5"/> <port id="pr_ae437c92-1aac-4587-8621-9087cb4eb946_p2" x="6125.25" y="1040.5"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_90d22503-34d6-46ed-baca-38337a0b26d5"> <bbox w="20.0" h="20.0" x="5971.6665" y="1066.6666"/> <port id="logicglyph_90d22503-34d6-46ed-baca-38337a0b26d5_p1" x="5961.6665" y="1076.6666"/> <port id="logicglyph_90d22503-34d6-46ed-baca-38337a0b26d5_p2" x="6001.6665" y="1076.6666"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_050df34d-f972-447f-9939-8585fced7949"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18414028 PMID:9106657 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5479.75" y="1384.25"/> <port id="pr_050df34d-f972-447f-9939-8585fced7949_p1" x="5499.75" y="1389.25"/> <port id="pr_050df34d-f972-447f-9939-8585fced7949_p2" x="5469.75" y="1389.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_466b8c77-2e93-42d2-ada7-5171e99290fc"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18787170 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5522.4375" y="1641.1561"/> <port id="pr_466b8c77-2e93-42d2-ada7-5171e99290fc_p1" x="5542.4375" y="1646.1561"/> <port id="pr_466b8c77-2e93-42d2-ada7-5171e99290fc_p2" x="5512.4375" y="1646.1561"/> </glyph> <glyph class="and" orientation="vertical" id="logicglyph_0cb5dc34-9b7b-45b6-929e-6ea4bb87afc9"> <bbox w="20.0" h="20.0" x="5574.2188" y="1730.083"/> <port id="logicglyph_0cb5dc34-9b7b-45b6-929e-6ea4bb87afc9_p1" x="5584.2188" y="1760.083"/> <port id="logicglyph_0cb5dc34-9b7b-45b6-929e-6ea4bb87afc9_p2" x="5584.2188" y="1720.083"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_996a596b-866f-4993-b015-06f9749c9b81"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11756412 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5377.75" y="2405.0"/> <port id="pr_996a596b-866f-4993-b015-06f9749c9b81_p1" x="5367.75" y="2410.0"/> <port id="pr_996a596b-866f-4993-b015-06f9749c9b81_p2" x="5397.75" y="2410.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_fc53303c-53d8-4748-a948-586907d539ff"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:9765224 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5654.0" y="2152.0"/> <port id="pr_fc53303c-53d8-4748-a948-586907d539ff_p1" x="5659.0" y="2172.0"/> <port id="pr_fc53303c-53d8-4748-a948-586907d539ff_p2" x="5659.0" y="2142.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_543b693f-ecfd-4b84-ac92-2480fa7ae619"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11756412 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5450.5" y="2372.0"/> <port id="pr_543b693f-ecfd-4b84-ac92-2480fa7ae619_p1" x="5455.5" y="2392.0"/> <port id="pr_543b693f-ecfd-4b84-ac92-2480fa7ae619_p2" x="5455.5" y="2362.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_40713f5d-0c01-47eb-a990-8e96ca00a9f6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19440234 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5621.25" y="2347.9387"/> <port id="pr_40713f5d-0c01-47eb-a990-8e96ca00a9f6_p1" x="5611.25" y="2352.9387"/> <port id="pr_40713f5d-0c01-47eb-a990-8e96ca00a9f6_p2" x="5641.25" y="2352.9387"/> </glyph> <glyph class="process" orientation="vertical" id="pr_e804445c-5545-4841-ac8e-9061dd0519ce"> <bbox w="10.0" h="10.0" x="6121.625" y="1475.0"/> <port id="pr_e804445c-5545-4841-ac8e-9061dd0519ce_p1" x="6126.625" y="1495.0"/> <port id="pr_e804445c-5545-4841-ac8e-9061dd0519ce_p2" x="6126.625" y="1465.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_29448f71-4853-49d4-8404-719ef48e5a8b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20932932 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4542.25" y="2461.0"/> <port id="pr_29448f71-4853-49d4-8404-719ef48e5a8b_p1" x="4532.25" y="2466.0"/> <port id="pr_29448f71-4853-49d4-8404-719ef48e5a8b_p2" x="4562.25" y="2466.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_4e7d84a3-1d61-42ce-9352-7103ab2755d5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20932932 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4711.5" y="2461.0"/> <port id="pr_4e7d84a3-1d61-42ce-9352-7103ab2755d5_p1" x="4701.5" y="2466.0"/> <port id="pr_4e7d84a3-1d61-42ce-9352-7103ab2755d5_p2" x="4731.5" y="2466.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5419a8ef-4eab-4083-968b-cea109188c72"> <bbox w="10.0" h="10.0" x="5789.08" y="1788.0"/> <port id="pr_5419a8ef-4eab-4083-968b-cea109188c72_p1" x="5779.08" y="1793.0"/> <port id="pr_5419a8ef-4eab-4083-968b-cea109188c72_p2" x="5809.08" y="1793.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_3a962dc6-724b-4085-b972-e6026ccca2cd"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20832730 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4585.5" y="917.0"/> <port id="pr_3a962dc6-724b-4085-b972-e6026ccca2cd_p1" x="4605.5" y="922.0"/> <port id="pr_3a962dc6-724b-4085-b972-e6026ccca2cd_p2" x="4575.5" y="922.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_cec1b7c0-ad1c-414d-baee-497bb0a791f2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20832730 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4856.25" y="665.5"/> <port id="pr_cec1b7c0-ad1c-414d-baee-497bb0a791f2_p1" x="4846.25" y="670.5"/> <port id="pr_cec1b7c0-ad1c-414d-baee-497bb0a791f2_p2" x="4876.25" y="670.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_9e847226-3539-4565-bd47-75feeb32f440"> <bbox w="10.0" h="10.0" x="4987.2676" y="754.1328"/> <port id="pr_9e847226-3539-4565-bd47-75feeb32f440_p1" x="4992.2676" y="744.1328"/> <port id="pr_9e847226-3539-4565-bd47-75feeb32f440_p2" x="4992.2676" y="774.1328"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_0318bc57-ca8d-4495-a889-372ca431b93b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20832730 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4706.4688" y="802.0"/> <port id="pr_0318bc57-ca8d-4495-a889-372ca431b93b_p1" x="4726.4688" y="807.0"/> <port id="pr_0318bc57-ca8d-4495-a889-372ca431b93b_p2" x="4696.4688" y="807.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_57b84356-ef19-492e-a332-ad7c09cbaa2c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19225151 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6523.3125" y="2328.0"/> <port id="pr_57b84356-ef19-492e-a332-ad7c09cbaa2c_p1" x="6528.3125" y="2318.0"/> <port id="pr_57b84356-ef19-492e-a332-ad7c09cbaa2c_p2" x="6528.3125" y="2348.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_84a73900-2be8-42e7-bcb6-7ce820308797"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19225151 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6619.1074" y="2418.5"/> <port id="pr_84a73900-2be8-42e7-bcb6-7ce820308797_p1" x="6609.1074" y="2423.5"/> <port id="pr_84a73900-2be8-42e7-bcb6-7ce820308797_p2" x="6639.1074" y="2423.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_665ce212-36c4-4d76-bd3d-076f0e952ce5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:19225151 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6437.6074" y="2418.5"/> <port id="pr_665ce212-36c4-4d76-bd3d-076f0e952ce5_p1" x="6457.6074" y="2423.5"/> <port id="pr_665ce212-36c4-4d76-bd3d-076f0e952ce5_p2" x="6427.6074" y="2423.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f37e5f65-a626-4373-8538-40147aca4fa3"> <bbox w="10.0" h="10.0" x="6241.9287" y="2418.25"/> <port id="pr_f37e5f65-a626-4373-8538-40147aca4fa3_p1" x="6261.9287" y="2423.25"/> <port id="pr_f37e5f65-a626-4373-8538-40147aca4fa3_p2" x="6231.9287" y="2423.25"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_ac575e0a-e701-49ad-b37c-12bea6d56af4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10783894 PMID:20673124 PMID:11094066 PMID:11994454 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5224.25" y="3032.413"/> <port id="pr_ac575e0a-e701-49ad-b37c-12bea6d56af4_p1" x="5214.25" y="3037.413"/> <port id="pr_ac575e0a-e701-49ad-b37c-12bea6d56af4_p2" x="5244.25" y="3037.413"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_26155b9f-65be-45a4-944e-6768b8e46622"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11154281 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4991.375" y="3019.25"/> <port id="pr_26155b9f-65be-45a4-944e-6768b8e46622_p1" x="5011.375" y="3024.25"/> <port id="pr_26155b9f-65be-45a4-944e-6768b8e46622_p2" x="4981.375" y="3024.25"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_7a5f5c70-7baa-45e7-ac5b-1e1af8f00334"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20673124 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5224.25" y="3105.0"/> <port id="pr_7a5f5c70-7baa-45e7-ac5b-1e1af8f00334_p1" x="5214.25" y="3110.0"/> <port id="pr_7a5f5c70-7baa-45e7-ac5b-1e1af8f00334_p2" x="5244.25" y="3110.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_01ab7f87-8f9f-40a8-89a7-6b6a5671d88e"> <bbox w="10.0" h="10.0" x="4850.125" y="3019.25"/> <port id="pr_01ab7f87-8f9f-40a8-89a7-6b6a5671d88e_p1" x="4870.125" y="3024.25"/> <port id="pr_01ab7f87-8f9f-40a8-89a7-6b6a5671d88e_p2" x="4840.125" y="3024.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_896a8213-5439-48cd-a94c-4686fd1404e4"> <bbox w="10.0" h="10.0" x="4804.4443" y="3091.125"/> <port id="pr_896a8213-5439-48cd-a94c-4686fd1404e4_p1" x="4809.4443" y="3081.125"/> <port id="pr_896a8213-5439-48cd-a94c-4686fd1404e4_p2" x="4809.4443" y="3111.125"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_486bdbf6-58d9-480c-9f81-c0b378a0a8fd"> <bbox w="10.0" h="10.0" x="4602.25" y="3120.75"/> <port id="pr_486bdbf6-58d9-480c-9f81-c0b378a0a8fd_p1" x="4592.25" y="3125.75"/> <port id="pr_486bdbf6-58d9-480c-9f81-c0b378a0a8fd_p2" x="4622.25" y="3125.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_cc3dd208-aa16-49a0-919a-be501b586af9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11864996 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4796.0" y="3223.25"/> <port id="pr_cc3dd208-aa16-49a0-919a-be501b586af9_p1" x="4801.0" y="3213.25"/> <port id="pr_cc3dd208-aa16-49a0-919a-be501b586af9_p2" x="4801.0" y="3243.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_96d712bb-78ea-4e12-aa56-aa2b1e1f8846"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11864996 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4630.75" y="3252.5"/> <port id="pr_96d712bb-78ea-4e12-aa56-aa2b1e1f8846_p1" x="4650.75" y="3257.5"/> <port id="pr_96d712bb-78ea-4e12-aa56-aa2b1e1f8846_p2" x="4620.75" y="3257.5"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_506e4d3d-b5a7-4286-ad68-268821fd6f35"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20673124 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5224.25" y="3177.0"/> <port id="pr_506e4d3d-b5a7-4286-ad68-268821fd6f35_p1" x="5214.25" y="3182.0"/> <port id="pr_506e4d3d-b5a7-4286-ad68-268821fd6f35_p2" x="5244.25" y="3182.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_a3b370c8-9218-4b28-8bf7-5ad5f9d36f1a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20673124 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5224.25" y="3248.0"/> <port id="pr_a3b370c8-9218-4b28-8bf7-5ad5f9d36f1a_p1" x="5214.25" y="3253.0"/> <port id="pr_a3b370c8-9218-4b28-8bf7-5ad5f9d36f1a_p2" x="5244.25" y="3253.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_e260afaf-67ff-4407-9ff8-a303909ded9e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20673124 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5224.25" y="3318.0"/> <port id="pr_e260afaf-67ff-4407-9ff8-a303909ded9e_p1" x="5214.25" y="3323.0"/> <port id="pr_e260afaf-67ff-4407-9ff8-a303909ded9e_p2" x="5244.25" y="3323.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_8e0bf40f-ecee-4814-93f0-50bfabeb4bbe"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18716620 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5566.375" y="3983.5"/> <port id="pr_8e0bf40f-ecee-4814-93f0-50bfabeb4bbe_p1" x="5571.375" y="3973.5"/> <port id="pr_8e0bf40f-ecee-4814-93f0-50bfabeb4bbe_p2" x="5571.375" y="4003.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b7ffa04a-c620-4d59-aedd-b03f78d5f63d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18716620 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5652.125" y="3984.5"/> <port id="pr_b7ffa04a-c620-4d59-aedd-b03f78d5f63d_p1" x="5657.125" y="3974.5"/> <port id="pr_b7ffa04a-c620-4d59-aedd-b03f78d5f63d_p2" x="5657.125" y="4004.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_163be7f3-dc7f-4da2-b68e-f17ba70af52c"> <bbox w="10.0" h="10.0" x="6201.125" y="4003.0"/> <port id="pr_163be7f3-dc7f-4da2-b68e-f17ba70af52c_p1" x="6191.125" y="4008.0"/> <port id="pr_163be7f3-dc7f-4da2-b68e-f17ba70af52c_p2" x="6221.125" y="4008.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_96fad95f-e8bb-4962-8fe4-b5289d2359e0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18716620 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5787.25" y="4018.0"/> <port id="pr_96fad95f-e8bb-4962-8fe4-b5289d2359e0_p1" x="5792.25" y="4038.0"/> <port id="pr_96fad95f-e8bb-4962-8fe4-b5289d2359e0_p2" x="5792.25" y="4008.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ea82951a-649f-4cab-9b5c-cae6dd134e3c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17218262 PMID:17218252 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5564.625" y="3872.0"/> <port id="pr_ea82951a-649f-4cab-9b5c-cae6dd134e3c_p1" x="5554.625" y="3877.0"/> <port id="pr_ea82951a-649f-4cab-9b5c-cae6dd134e3c_p2" x="5584.625" y="3877.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_17a224a0-a29a-436e-8bd3-a817aeea7847"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17218262 PMID:17218252 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5650.375" y="3873.0"/> <port id="pr_17a224a0-a29a-436e-8bd3-a817aeea7847_p1" x="5670.375" y="3878.0"/> <port id="pr_17a224a0-a29a-436e-8bd3-a817aeea7847_p2" x="5640.375" y="3878.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_5e60e04e-939f-455e-8ac6-d46e7ace29e5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17218262 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5224.25" y="3416.0"/> <port id="pr_5e60e04e-939f-455e-8ac6-d46e7ace29e5_p1" x="5214.25" y="3421.0"/> <port id="pr_5e60e04e-939f-455e-8ac6-d46e7ace29e5_p2" x="5244.25" y="3421.0"/> </glyph> <glyph class="and" orientation="vertical" id="logicglyph_c7786e53-0142-41bc-aa1c-fbdf2937080a"> <bbox w="20.0" h="20.0" x="5230.2676" y="3441.38"/> <port id="logicglyph_c7786e53-0142-41bc-aa1c-fbdf2937080a_p1" x="5240.2676" y="3471.38"/> <port id="logicglyph_c7786e53-0142-41bc-aa1c-fbdf2937080a_p2" x="5240.2676" y="3431.38"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6d174000-ec1c-4d77-a67b-8687ecc8cc31"> <bbox w="10.0" h="10.0" x="5544.625" y="3782.5"/> <port id="pr_6d174000-ec1c-4d77-a67b-8687ecc8cc31_p1" x="5534.625" y="3787.5"/> <port id="pr_6d174000-ec1c-4d77-a67b-8687ecc8cc31_p2" x="5564.625" y="3787.5"/> </glyph> <glyph class="omitted process" orientation="vertical" id="pr_3fb53989-4bcd-47e2-a5f1-139e6270e606"> <bbox w="10.0" h="10.0" x="5383.25" y="3565.75"/> <port id="pr_3fb53989-4bcd-47e2-a5f1-139e6270e606_p1" x="5388.25" y="3555.75"/> <port id="pr_3fb53989-4bcd-47e2-a5f1-139e6270e606_p2" x="5388.25" y="3585.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_4866aa7c-546b-406e-a99a-1f0d05ffe8fe"> <bbox w="10.0" h="10.0" x="6240.5" y="3892.0"/> <port id="pr_4866aa7c-546b-406e-a99a-1f0d05ffe8fe_p1" x="6260.5" y="3897.0"/> <port id="pr_4866aa7c-546b-406e-a99a-1f0d05ffe8fe_p2" x="6230.5" y="3897.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a3534a04-0e64-4d24-a4a6-984d3cbddc96"> <bbox w="10.0" h="10.0" x="6154.75" y="3859.0"/> <port id="pr_a3534a04-0e64-4d24-a4a6-984d3cbddc96_p1" x="6174.75" y="3864.0"/> <port id="pr_a3534a04-0e64-4d24-a4a6-984d3cbddc96_p2" x="6144.75" y="3864.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5d17953d-84d2-460d-ab22-4d3cbc27fc69"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16680151 PMID:20452955 PMID:19216069 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5470.75" y="4298.25"/> <port id="pr_5d17953d-84d2-460d-ab22-4d3cbc27fc69_p1" x="5475.75" y="4288.25"/> <port id="pr_5d17953d-84d2-460d-ab22-4d3cbc27fc69_p2" x="5475.75" y="4318.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_7d2bbee4-bdba-427e-ad3b-1af874437b72"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16680151 PMID:20452955 PMID:19216069 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5029.0" y="3042.5"/> <port id="pr_7d2bbee4-bdba-427e-ad3b-1af874437b72_p1" x="5019.0" y="3047.5"/> <port id="pr_7d2bbee4-bdba-427e-ad3b-1af874437b72_p2" x="5049.0" y="3047.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5cd3d29a-ce8c-43c4-a271-32e35b3e97ec"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:16680151 PMID:20452955 PMID:19216069 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5661.4473" y="4311.0"/> <port id="pr_5cd3d29a-ce8c-43c4-a271-32e35b3e97ec_p1" x="5666.4473" y="4301.0"/> <port id="pr_5cd3d29a-ce8c-43c4-a271-32e35b3e97ec_p2" x="5666.4473" y="4331.0"/> </glyph> <glyph class="omitted process" orientation="vertical" id="pr_f596602f-567d-40b6-bb3d-5fe3be64a9fe"> <bbox w="10.0" h="10.0" x="5364.25" y="2855.75"/> <port id="pr_f596602f-567d-40b6-bb3d-5fe3be64a9fe_p1" x="5369.25" y="2875.75"/> <port id="pr_f596602f-567d-40b6-bb3d-5fe3be64a9fe_p2" x="5369.25" y="2845.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_956cb6c9-5de9-4a73-a835-f9e78ec8fc9d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:19887899 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5595.5" y="3031.25"/> <port id="pr_956cb6c9-5de9-4a73-a835-f9e78ec8fc9d_p1" x="5600.5" y="3021.25"/> <port id="pr_956cb6c9-5de9-4a73-a835-f9e78ec8fc9d_p2" x="5600.5" y="3051.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_54ebf32d-248c-4908-9e99-4444c76825dd"> <bbox w="10.0" h="10.0" x="5711.0" y="2994.0"/> <port id="pr_54ebf32d-248c-4908-9e99-4444c76825dd_p1" x="5716.0" y="2984.0"/> <port id="pr_54ebf32d-248c-4908-9e99-4444c76825dd_p2" x="5716.0" y="3014.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_e04cd600-1d51-40ec-a890-f5cbcaf97df2"> <bbox w="10.0" h="10.0" x="5595.5" y="3121.75"/> <port id="pr_e04cd600-1d51-40ec-a890-f5cbcaf97df2_p1" x="5600.5" y="3111.75"/> <port id="pr_e04cd600-1d51-40ec-a890-f5cbcaf97df2_p2" x="5600.5" y="3141.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_28ef33e6-abd8-47cc-96a0-56d41f525311"> <bbox w="10.0" h="10.0" x="5652.75" y="3064.5"/> <port id="pr_28ef33e6-abd8-47cc-96a0-56d41f525311_p1" x="5657.75" y="3084.5"/> <port id="pr_28ef33e6-abd8-47cc-96a0-56d41f525311_p2" x="5657.75" y="3054.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_4e3ce083-1b63-4a5f-a4f6-772f492d3e66"> <bbox w="10.0" h="10.0" x="5432.0" y="2994.5"/> <port id="pr_4e3ce083-1b63-4a5f-a4f6-772f492d3e66_p1" x="5437.0" y="2984.5"/> <port id="pr_4e3ce083-1b63-4a5f-a4f6-772f492d3e66_p2" x="5437.0" y="3014.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_65cb2e66-0ec9-4d84-8ca2-bf73820748ef"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:15147722 PMID:14536078 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5473.358" y="3204.5"/> <port id="pr_65cb2e66-0ec9-4d84-8ca2-bf73820748ef_p1" x="5478.358" y="3194.5"/> <port id="pr_65cb2e66-0ec9-4d84-8ca2-bf73820748ef_p2" x="5478.358" y="3224.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_b23934af-3305-4693-8b7a-5d7f118fd43b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18636226 PMID:15147722 PMID:14536078 PMID:12459251 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5616.0" y="3273.7253"/> <port id="pr_b23934af-3305-4693-8b7a-5d7f118fd43b_p1" x="5606.0" y="3278.7253"/> <port id="pr_b23934af-3305-4693-8b7a-5d7f118fd43b_p2" x="5636.0" y="3278.7253"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a64fbe3e-61ba-4027-ba5a-93101dcfa59d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15147722 PMID:18006823 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5976.5" y="3270.0"/> <port id="pr_a64fbe3e-61ba-4027-ba5a-93101dcfa59d_p1" x="5966.5" y="3275.0"/> <port id="pr_a64fbe3e-61ba-4027-ba5a-93101dcfa59d_p2" x="5996.5" y="3275.0"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_1409d098-4075-4455-b903-e424964311d1"> <bbox w="20.0" h="20.0" x="5881.4014" y="3234.2107"/> <port id="logicglyph_1409d098-4075-4455-b903-e424964311d1_p1" x="5871.4014" y="3244.2107"/> <port id="logicglyph_1409d098-4075-4455-b903-e424964311d1_p2" x="5911.4014" y="3244.2107"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_fd6b3e13-b8f8-4819-b813-30fcdc573fe9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18636226 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6408.5" y="3331.9612"/> <port id="pr_fd6b3e13-b8f8-4819-b813-30fcdc573fe9_p1" x="6398.5" y="3336.9612"/> <port id="pr_fd6b3e13-b8f8-4819-b813-30fcdc573fe9_p2" x="6428.5" y="3336.9612"/> </glyph> <glyph class="process" orientation="vertical" id="pr_7979eebb-e4e3-4a04-b152-74415cf2e664"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18636226 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6626.25" y="3253.0"/> <port id="pr_7979eebb-e4e3-4a04-b152-74415cf2e664_p1" x="6631.25" y="3273.0"/> <port id="pr_7979eebb-e4e3-4a04-b152-74415cf2e664_p2" x="6631.25" y="3243.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_3a95126f-a440-43c6-86e4-d399f4459c1b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18636226 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6744.2734" y="3254.375"/> <port id="pr_3a95126f-a440-43c6-86e4-d399f4459c1b_p1" x="6749.2734" y="3244.375"/> <port id="pr_3a95126f-a440-43c6-86e4-d399f4459c1b_p2" x="6749.2734" y="3274.375"/> </glyph> <glyph class="process" orientation="vertical" id="pr_8d3f762b-e61f-48ec-96d8-ed9b5121d7a9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15531880 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6799.5" y="3361.0"/> <port id="pr_8d3f762b-e61f-48ec-96d8-ed9b5121d7a9_p1" x="6804.5" y="3351.0"/> <port id="pr_8d3f762b-e61f-48ec-96d8-ed9b5121d7a9_p2" x="6804.5" y="3381.0"/> </glyph> <glyph class="and" orientation="vertical" id="logicglyph_2cadcc14-0f84-4968-8da0-abc2b7e68a02"> <bbox w="20.0" h="20.0" x="6744.2456" y="3405.4404"/> <port id="logicglyph_2cadcc14-0f84-4968-8da0-abc2b7e68a02_p1" x="6754.2456" y="3435.4404"/> <port id="logicglyph_2cadcc14-0f84-4968-8da0-abc2b7e68a02_p2" x="6754.2456" y="3395.4404"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d47e4ea6-0163-434a-b6e4-94372a3a0f78"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15147722 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6480.0" y="3106.0"/> <port id="pr_d47e4ea6-0163-434a-b6e4-94372a3a0f78_p1" x="6470.0" y="3111.0"/> <port id="pr_d47e4ea6-0163-434a-b6e4-94372a3a0f78_p2" x="6500.0" y="3111.0"/> </glyph> <glyph class="omitted process" orientation="vertical" id="pr_1c1c3db3-e93f-4c89-abe5-f9a73f0955c9"> <bbox w="10.0" h="10.0" x="5797.0" y="3095.5"/> <port id="pr_1c1c3db3-e93f-4c89-abe5-f9a73f0955c9_p1" x="5802.0" y="3115.5"/> <port id="pr_1c1c3db3-e93f-4c89-abe5-f9a73f0955c9_p2" x="5802.0" y="3085.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1e8330ca-251d-43da-870b-ab7ebba743ed"> <bbox w="10.0" h="10.0" x="5506.25" y="2828.5"/> <port id="pr_1e8330ca-251d-43da-870b-ab7ebba743ed_p1" x="5511.25" y="2818.5"/> <port id="pr_1e8330ca-251d-43da-870b-ab7ebba743ed_p2" x="5511.25" y="2848.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b1cd7436-960e-48f0-8ae3-9121c41925c7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:18414028 PMID:9106657 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5581.0" y="3083.25"/> <port id="pr_b1cd7436-960e-48f0-8ae3-9121c41925c7_p1" x="5586.0" y="3073.25"/> <port id="pr_b1cd7436-960e-48f0-8ae3-9121c41925c7_p2" x="5586.0" y="3103.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_25448616-c37d-4764-b0dd-14927a76cc35"> <bbox w="10.0" h="10.0" x="5417.75" y="3160.5"/> <port id="pr_25448616-c37d-4764-b0dd-14927a76cc35_p1" x="5422.75" y="3180.5"/> <port id="pr_25448616-c37d-4764-b0dd-14927a76cc35_p2" x="5422.75" y="3150.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_4cb4b152-9094-40d0-9056-a892acf677ce"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:14536078 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5511.75" y="3266.0"/> <port id="pr_4cb4b152-9094-40d0-9056-a892acf677ce_p1" x="5516.75" y="3256.0"/> <port id="pr_4cb4b152-9094-40d0-9056-a892acf677ce_p2" x="5516.75" y="3286.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f5f0d204-51fc-40ae-a2fa-9617383613f7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:14536078 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5624.5" y="3450.0"/> <port id="pr_f5f0d204-51fc-40ae-a2fa-9617383613f7_p1" x="5614.5" y="3455.0"/> <port id="pr_f5f0d204-51fc-40ae-a2fa-9617383613f7_p2" x="5644.5" y="3455.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9e8e4d89-dfd3-468a-b743-e3738ff32e71"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:14536078 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5899.25" y="3394.75"/> <port id="pr_9e8e4d89-dfd3-468a-b743-e3738ff32e71_p1" x="5889.25" y="3399.75"/> <port id="pr_9e8e4d89-dfd3-468a-b743-e3738ff32e71_p2" x="5919.25" y="3399.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5ea936ca-e549-454f-b372-23fcf31b75e9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:14536078 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6088.25" y="3515.5"/> <port id="pr_5ea936ca-e549-454f-b372-23fcf31b75e9_p1" x="6078.25" y="3520.5"/> <port id="pr_5ea936ca-e549-454f-b372-23fcf31b75e9_p2" x="6108.25" y="3520.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_211c91a7-f773-4e6f-a95e-c2a27e42cb4f"> <bbox w="10.0" h="10.0" x="5761.0" y="3450.0"/> <port id="pr_211c91a7-f773-4e6f-a95e-c2a27e42cb4f_p1" x="5751.0" y="3455.0"/> <port id="pr_211c91a7-f773-4e6f-a95e-c2a27e42cb4f_p2" x="5781.0" y="3455.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5aaed425-7759-4f17-a23e-195fa62219e6"> <bbox w="10.0" h="10.0" x="6223.75" y="3515.5"/> <port id="pr_5aaed425-7759-4f17-a23e-195fa62219e6_p1" x="6213.75" y="3520.5"/> <port id="pr_5aaed425-7759-4f17-a23e-195fa62219e6_p2" x="6243.75" y="3520.5"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_27c7fa11-241b-4aa8-96cf-af6cf4d70a1a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID15509806 PMID20673124 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5224.25" y="3564.0"/> <port id="pr_27c7fa11-241b-4aa8-96cf-af6cf4d70a1a_p1" x="5214.25" y="3569.0"/> <port id="pr_27c7fa11-241b-4aa8-96cf-af6cf4d70a1a_p2" x="5244.25" y="3569.0"/> </glyph> <glyph class="omitted process" orientation="vertical" id="pr_c1532be4-dfa3-4d33-8a65-f4d1561f8b76"> <bbox w="10.0" h="10.0" x="5505.5" y="3140.25"/> <port id="pr_c1532be4-dfa3-4d33-8a65-f4d1561f8b76_p1" x="5510.5" y="3160.25"/> <port id="pr_c1532be4-dfa3-4d33-8a65-f4d1561f8b76_p2" x="5510.5" y="3130.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_d057a24f-b40d-425e-8ad8-9649dac904b9"> <bbox w="10.0" h="10.0" x="5849.5" y="2991.0"/> <port id="pr_d057a24f-b40d-425e-8ad8-9649dac904b9_p1" x="5854.5" y="2981.0"/> <port id="pr_d057a24f-b40d-425e-8ad8-9649dac904b9_p2" x="5854.5" y="3011.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a0df1046-7946-45bb-84b5-743fba0c7188"> <bbox w="10.0" h="10.0" x="6203.0" y="3216.0"/> <port id="pr_a0df1046-7946-45bb-84b5-743fba0c7188_p1" x="6193.0" y="3221.0"/> <port id="pr_a0df1046-7946-45bb-84b5-743fba0c7188_p2" x="6223.0" y="3221.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ab72c698-b138-481f-8bce-4b635613c579"> <bbox w="10.0" h="10.0" x="5655.0" y="3053.5"/> <port id="pr_ab72c698-b138-481f-8bce-4b635613c579_p1" x="5645.0" y="3058.5"/> <port id="pr_ab72c698-b138-481f-8bce-4b635613c579_p2" x="5675.0" y="3058.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_91c155c0-d69d-4786-97e6-5610b8850da2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID15169778 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5937.0" y="4402.0"/> <port id="pr_91c155c0-d69d-4786-97e6-5610b8850da2_p1" x="5942.0" y="4392.0"/> <port id="pr_91c155c0-d69d-4786-97e6-5610b8850da2_p2" x="5942.0" y="4422.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_43c4abe3-400b-49ba-a5a7-935fa9597709"> <bbox w="10.0" h="10.0" x="5222.25" y="3721.587"/> <port id="pr_43c4abe3-400b-49ba-a5a7-935fa9597709_p1" x="5212.25" y="3726.587"/> <port id="pr_43c4abe3-400b-49ba-a5a7-935fa9597709_p2" x="5242.25" y="3726.587"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f219548c-7ad0-4cbe-bd7d-8bcaa664d3bc"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15169778 PMID:10722742 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5882.0" y="4352.0"/> <port id="pr_f219548c-7ad0-4cbe-bd7d-8bcaa664d3bc_p1" x="5902.0" y="4357.0"/> <port id="pr_f219548c-7ad0-4cbe-bd7d-8bcaa664d3bc_p2" x="5872.0" y="4357.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_72db6525-506e-4990-ba2e-ad7710adfe49"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:10721693 PMID:19459846 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6040.25" y="4222.0"/> <port id="pr_72db6525-506e-4990-ba2e-ad7710adfe49_p1" x="6030.25" y="4227.0"/> <port id="pr_72db6525-506e-4990-ba2e-ad7710adfe49_p2" x="6060.25" y="4227.0"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_95a46d48-c9a8-43a1-9c6d-cb2e2f4cae24"> <bbox w="20.0" h="20.0" x="5422.75" y="3768.25"/> <port id="logicglyph_95a46d48-c9a8-43a1-9c6d-cb2e2f4cae24_p1" x="5412.75" y="3778.25"/> <port id="logicglyph_95a46d48-c9a8-43a1-9c6d-cb2e2f4cae24_p2" x="5452.75" y="3778.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_0dd6e553-f305-46be-89e6-d057535f4bd4"> <bbox w="10.0" h="10.0" x="6126.0" y="4533.5"/> <port id="pr_0dd6e553-f305-46be-89e6-d057535f4bd4_p1" x="6131.0" y="4523.5"/> <port id="pr_0dd6e553-f305-46be-89e6-d057535f4bd4_p2" x="6131.0" y="4553.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1b481012-b648-434e-922e-f30a503158c9"> <bbox w="10.0" h="10.0" x="4438.492" y="3097.0"/> <port id="pr_1b481012-b648-434e-922e-f30a503158c9_p1" x="4443.492" y="3117.0"/> <port id="pr_1b481012-b648-434e-922e-f30a503158c9_p2" x="4443.492" y="3087.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_eca13609-2a0b-44b8-bc94-3750ff336bfe"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19321440 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4467.25" y="2892.5"/> <port id="pr_eca13609-2a0b-44b8-bc94-3750ff336bfe_p1" x="4472.25" y="2912.5"/> <port id="pr_eca13609-2a0b-44b8-bc94-3750ff336bfe_p2" x="4472.25" y="2882.5"/> </glyph> <glyph class="and" orientation="vertical" id="logicglyph_0dd96445-25b7-4e98-a82b-33fa5f87c696"> <bbox w="20.0" h="20.0" x="4555.0" y="2705.75"/> <port id="logicglyph_0dd96445-25b7-4e98-a82b-33fa5f87c696_p1" x="4565.0" y="2695.75"/> <port id="logicglyph_0dd96445-25b7-4e98-a82b-33fa5f87c696_p2" x="4565.0" y="2735.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f458ef84-2ea4-442a-8d91-b3a4d770d1e6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:10721693 PMID:19459846 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6040.25" y="4251.0"/> <port id="pr_f458ef84-2ea4-442a-8d91-b3a4d770d1e6_p1" x="6030.25" y="4256.0"/> <port id="pr_f458ef84-2ea4-442a-8d91-b3a4d770d1e6_p2" x="6060.25" y="4256.0"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_f2da88e6-9af4-470d-85bf-5b652bf93120"> <bbox w="20.0" h="20.0" x="5420.0" y="3776.0"/> <port id="logicglyph_f2da88e6-9af4-470d-85bf-5b652bf93120_p1" x="5410.0" y="3786.0"/> <port id="logicglyph_f2da88e6-9af4-470d-85bf-5b652bf93120_p2" x="5450.0" y="3786.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_be90498e-71af-41b1-b37f-bcf7e7475703"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:17646672 PMID20673124 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5224.25" y="3367.0"/> <port id="pr_be90498e-71af-41b1-b37f-bcf7e7475703_p1" x="5214.25" y="3372.0"/> <port id="pr_be90498e-71af-41b1-b37f-bcf7e7475703_p2" x="5244.25" y="3372.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_8e8a26cb-cccd-4a0a-8b88-db6f775be476"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID15084260 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5062.0" y="3116.625"/> <port id="pr_8e8a26cb-cccd-4a0a-8b88-db6f775be476_p1" x="5067.0" y="3106.625"/> <port id="pr_8e8a26cb-cccd-4a0a-8b88-db6f775be476_p2" x="5067.0" y="3136.625"/> </glyph> <glyph class="process" orientation="vertical" id="pr_2e4fc40c-0c72-4e29-8a10-b9146acecd49"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID15084260 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5007.625" y="3214.0"/> <port id="pr_2e4fc40c-0c72-4e29-8a10-b9146acecd49_p1" x="5012.625" y="3234.0"/> <port id="pr_2e4fc40c-0c72-4e29-8a10-b9146acecd49_p2" x="5012.625" y="3204.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_26c6e6d5-89de-4d30-bd83-ab0f4e80e4a8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15084260 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4975.25" y="2998.837"/> <port id="pr_26c6e6d5-89de-4d30-bd83-ab0f4e80e4a8_p1" x="4980.25" y="3018.837"/> <port id="pr_26c6e6d5-89de-4d30-bd83-ab0f4e80e4a8_p2" x="4980.25" y="2988.837"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_6b5254d1-0922-451b-ab28-e5033bb8b64d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15509806 PMID:20673124 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5222.25" y="3772.0"/> <port id="pr_6b5254d1-0922-451b-ab28-e5033bb8b64d_p1" x="5212.25" y="3777.0"/> <port id="pr_6b5254d1-0922-451b-ab28-e5033bb8b64d_p2" x="5242.25" y="3777.0"/> </glyph> <glyph class="omitted process" orientation="vertical" id="pr_b4d81246-45a8-463b-a261-0868614e94c0"> <bbox w="10.0" h="10.0" x="5275.162" y="3705.25"/> <port id="pr_b4d81246-45a8-463b-a261-0868614e94c0_p1" x="5280.162" y="3725.25"/> <port id="pr_b4d81246-45a8-463b-a261-0868614e94c0_p2" x="5280.162" y="3695.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a53112d6-94bb-44a7-b6bb-f4e8cad8fbef"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17646672 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4996.125" y="3680.0"/> <port id="pr_a53112d6-94bb-44a7-b6bb-f4e8cad8fbef_p1" x="5001.125" y="3670.0"/> <port id="pr_a53112d6-94bb-44a7-b6bb-f4e8cad8fbef_p2" x="5001.125" y="3700.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c6e99245-2aee-4704-996a-dcf0be16a006"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15668399 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4470.25" y="4943.0"/> <port id="pr_c6e99245-2aee-4704-996a-dcf0be16a006_p1" x="4475.25" y="4933.0"/> <port id="pr_c6e99245-2aee-4704-996a-dcf0be16a006_p2" x="4475.25" y="4963.0"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_31366f66-983d-42b2-a41d-39301f7a884b"> <bbox w="20.0" h="20.0" x="4711.0" y="4959.25"/> <port id="logicglyph_31366f66-983d-42b2-a41d-39301f7a884b_p1" x="4741.0" y="4969.25"/> <port id="logicglyph_31366f66-983d-42b2-a41d-39301f7a884b_p2" x="4701.0" y="4969.25"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_b59caffe-c894-4530-9a4c-692d243c2c40"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID19244250 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5223.25" y="3821.0"/> <port id="pr_b59caffe-c894-4530-9a4c-692d243c2c40_p1" x="5213.25" y="3826.0"/> <port id="pr_b59caffe-c894-4530-9a4c-692d243c2c40_p2" x="5243.25" y="3826.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_fc4e3fbc-8949-486f-bd89-f81db37ee5df"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20673124 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5223.25" y="3939.0"/> <port id="pr_fc4e3fbc-8949-486f-bd89-f81db37ee5df_p1" x="5213.25" y="3944.0"/> <port id="pr_fc4e3fbc-8949-486f-bd89-f81db37ee5df_p2" x="5243.25" y="3944.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_1d5660d5-2543-4708-a736-24b088ba6b30"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20673124 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5223.25" y="3988.0"/> <port id="pr_1d5660d5-2543-4708-a736-24b088ba6b30_p1" x="5213.25" y="3993.0"/> <port id="pr_1d5660d5-2543-4708-a736-24b088ba6b30_p2" x="5243.25" y="3993.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_f3b78f3a-ffc8-457f-ac47-cab4a56afadd"> <bbox w="10.0" h="10.0" x="5222.25" y="3680.0"/> <port id="pr_f3b78f3a-ffc8-457f-ac47-cab4a56afadd_p1" x="5212.25" y="3685.0"/> <port id="pr_f3b78f3a-ffc8-457f-ac47-cab4a56afadd_p2" x="5242.25" y="3685.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_55db037f-3036-4b8a-b7c1-439be817743b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20673124 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5223.25" y="4031.0"/> <port id="pr_55db037f-3036-4b8a-b7c1-439be817743b_p1" x="5213.25" y="4036.0"/> <port id="pr_55db037f-3036-4b8a-b7c1-439be817743b_p2" x="5243.25" y="4036.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_8185f9a4-c7b7-4efc-a3bd-5ac9b73e242c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20673124 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5223.25" y="4077.0"/> <port id="pr_8185f9a4-c7b7-4efc-a3bd-5ac9b73e242c_p1" x="5213.25" y="4082.0"/> <port id="pr_8185f9a4-c7b7-4efc-a3bd-5ac9b73e242c_p2" x="5243.25" y="4082.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_2fba6278-3d28-4d30-8f92-9e8441655c41"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20673124 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5223.25" y="3862.0"/> <port id="pr_2fba6278-3d28-4d30-8f92-9e8441655c41_p1" x="5213.25" y="3867.0"/> <port id="pr_2fba6278-3d28-4d30-8f92-9e8441655c41_p2" x="5243.25" y="3867.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_eede5ef1-327a-4e3f-8660-8faf023ce0a7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20673124 PMID:18644865 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5223.25" y="4122.0"/> <port id="pr_eede5ef1-327a-4e3f-8660-8faf023ce0a7_p1" x="5213.25" y="4127.0"/> <port id="pr_eede5ef1-327a-4e3f-8660-8faf023ce0a7_p2" x="5243.25" y="4127.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_1e40b5ba-e8b2-4d76-a39f-04cb89c62471"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15668399 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4946.5" y="4003.6665"/> <port id="pr_1e40b5ba-e8b2-4d76-a39f-04cb89c62471_p1" x="4966.5" y="4008.6665"/> <port id="pr_1e40b5ba-e8b2-4d76-a39f-04cb89c62471_p2" x="4936.5" y="4008.6665"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_fe752971-edb0-456a-bfef-a83561e0a7c9"> <bbox w="10.0" h="10.0" x="4905.25" y="3539.5"/> <port id="pr_fe752971-edb0-456a-bfef-a83561e0a7c9_p1" x="4895.25" y="3544.5"/> <port id="pr_fe752971-edb0-456a-bfef-a83561e0a7c9_p2" x="4925.25" y="3544.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5aa17192-c89b-4aeb-9f34-323a4132608d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11313479 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4814.5" y="3796.1692"/> <port id="pr_5aa17192-c89b-4aeb-9f34-323a4132608d_p1" x="4834.5" y="3801.1692"/> <port id="pr_5aa17192-c89b-4aeb-9f34-323a4132608d_p2" x="4804.5" y="3801.1692"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c86d6ea8-8877-49be-bb33-a7918c95629a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11313479 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4591.75" y="3814.5"/> <port id="pr_c86d6ea8-8877-49be-bb33-a7918c95629a_p1" x="4611.75" y="3819.5"/> <port id="pr_c86d6ea8-8877-49be-bb33-a7918c95629a_p2" x="4581.75" y="3819.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_36686a78-af1b-4e48-9ab1-0a27fd3e03db"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11313479 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4448.5454" y="3713.0"/> <port id="pr_36686a78-af1b-4e48-9ab1-0a27fd3e03db_p1" x="4453.5454" y="3733.0"/> <port id="pr_36686a78-af1b-4e48-9ab1-0a27fd3e03db_p2" x="4453.5454" y="3703.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ca075c04-b9ba-44fe-85cc-6c233827e677"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11313479 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4587.75" y="3404.5"/> <port id="pr_ca075c04-b9ba-44fe-85cc-6c233827e677_p1" x="4577.75" y="3409.5"/> <port id="pr_ca075c04-b9ba-44fe-85cc-6c233827e677_p2" x="4607.75" y="3409.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_78bfce87-17b5-417b-91ed-2412f018cc88"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11313479 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4727.8037" y="3555.0"/> <port id="pr_78bfce87-17b5-417b-91ed-2412f018cc88_p1" x="4732.8037" y="3545.0"/> <port id="pr_78bfce87-17b5-417b-91ed-2412f018cc88_p2" x="4732.8037" y="3575.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_6cd72e2f-37e9-44a7-a431-5140f8478036"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10217147 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4912.5" y="3735.0"/> <port id="pr_6cd72e2f-37e9-44a7-a431-5140f8478036_p1" x="4917.5" y="3725.0"/> <port id="pr_6cd72e2f-37e9-44a7-a431-5140f8478036_p2" x="4917.5" y="3755.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_031db9ce-5bef-437e-8174-422412d28be3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11313479 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4446.5273" y="3434.5"/> <port id="pr_031db9ce-5bef-437e-8174-422412d28be3_p1" x="4451.5273" y="3454.5"/> <port id="pr_031db9ce-5bef-437e-8174-422412d28be3_p2" x="4451.5273" y="3424.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5f98e666-df45-42dc-ad54-10d9f1056e44"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11313479 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4822.75" y="3919.0952"/> <port id="pr_5f98e666-df45-42dc-ad54-10d9f1056e44_p1" x="4842.75" y="3924.0952"/> <port id="pr_5f98e666-df45-42dc-ad54-10d9f1056e44_p2" x="4812.75" y="3924.0952"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c75d669b-90be-4275-a4b0-d6fc87ab5599"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11313479 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4592.25" y="3951.5"/> <port id="pr_c75d669b-90be-4275-a4b0-d6fc87ab5599_p1" x="4612.25" y="3956.5"/> <port id="pr_c75d669b-90be-4275-a4b0-d6fc87ab5599_p2" x="4582.25" y="3956.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c32f9e31-53fb-4fc0-962d-9803eb0f644c"> <bbox w="10.0" h="10.0" x="4449.5713" y="4039.0"/> <port id="pr_c32f9e31-53fb-4fc0-962d-9803eb0f644c_p1" x="4454.5713" y="4029.0"/> <port id="pr_c32f9e31-53fb-4fc0-962d-9803eb0f644c_p2" x="4454.5713" y="4059.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_642f9321-2d5f-4240-ab9e-5287d4599772"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:14664696 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4794.75" y="4121.25"/> <port id="pr_642f9321-2d5f-4240-ab9e-5287d4599772_p1" x="4799.75" y="4111.25"/> <port id="pr_642f9321-2d5f-4240-ab9e-5287d4599772_p2" x="4799.75" y="4141.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_dd7ff721-c0ba-4035-819b-70dc62d46150"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:14664696 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4601.25" y="4329.0"/> <port id="pr_dd7ff721-c0ba-4035-819b-70dc62d46150_p1" x="4606.25" y="4319.0"/> <port id="pr_dd7ff721-c0ba-4035-819b-70dc62d46150_p2" x="4606.25" y="4349.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_d612a249-be29-42b8-af60-1f656689d34c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:14664696 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4461.666" y="4536.5"/> <port id="pr_d612a249-be29-42b8-af60-1f656689d34c_p1" x="4466.666" y="4526.5"/> <port id="pr_d612a249-be29-42b8-af60-1f656689d34c_p2" x="4466.666" y="4556.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1277e090-219c-45fe-ba40-dd0e165a3d83"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11980723 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4866.25" y="4091.5"/> <port id="pr_1277e090-219c-45fe-ba40-dd0e165a3d83_p1" x="4871.25" y="4081.5"/> <port id="pr_1277e090-219c-45fe-ba40-dd0e165a3d83_p2" x="4871.25" y="4111.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_85aeeedf-50a5-4d84-ab76-13c8b7139914"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11980723 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4866.25" y="4209.5"/> <port id="pr_85aeeedf-50a5-4d84-ab76-13c8b7139914_p1" x="4871.25" y="4199.5"/> <port id="pr_85aeeedf-50a5-4d84-ab76-13c8b7139914_p2" x="4871.25" y="4229.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_84fe8c53-e347-44bc-b62b-4a5d598ad551"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11980723 PMID:14664696 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4772.554" y="4376.0"/> <port id="pr_84fe8c53-e347-44bc-b62b-4a5d598ad551_p1" x="4777.554" y="4366.0"/> <port id="pr_84fe8c53-e347-44bc-b62b-4a5d598ad551_p2" x="4777.554" y="4396.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_4223d82a-3aa5-477c-ac7c-40720e7eb89a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11980723 PMID:14664696 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4936.0" y="4692.5"/> <port id="pr_4223d82a-3aa5-477c-ac7c-40720e7eb89a_p1" x="4926.0" y="4697.5"/> <port id="pr_4223d82a-3aa5-477c-ac7c-40720e7eb89a_p2" x="4956.0" y="4697.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8336b9de-3329-460c-86a4-ca67586ddea1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11980723 PMID:14664696 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4856.625" y="4830.259"/> <port id="pr_8336b9de-3329-460c-86a4-ca67586ddea1_p1" x="4876.625" y="4835.259"/> <port id="pr_8336b9de-3329-460c-86a4-ca67586ddea1_p2" x="4846.625" y="4835.259"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_0e4c37a1-c1ce-4e70-9893-293ddeb31c3c"> <bbox w="10.0" h="10.0" x="4543.5" y="4254.248"/> <port id="pr_0e4c37a1-c1ce-4e70-9893-293ddeb31c3c_p1" x="4563.5" y="4259.248"/> <port id="pr_0e4c37a1-c1ce-4e70-9893-293ddeb31c3c_p2" x="4533.5" y="4259.248"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f60c0a90-773a-4efb-adc3-e8528a06861d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15084260 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5116.4375" y="2742.6736"/> <port id="pr_f60c0a90-773a-4efb-adc3-e8528a06861d_p1" x="5106.4375" y="2747.6736"/> <port id="pr_f60c0a90-773a-4efb-adc3-e8528a06861d_p2" x="5136.4375" y="2747.6736"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_cbb877db-85a6-4288-9bcd-48ac2803d49f"> <bbox w="20.0" h="20.0" x="4656.25" y="2673.25"/> <port id="logicglyph_cbb877db-85a6-4288-9bcd-48ac2803d49f_p1" x="4646.25" y="2683.25"/> <port id="logicglyph_cbb877db-85a6-4288-9bcd-48ac2803d49f_p2" x="4686.25" y="2683.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_7a641519-1b5e-4889-9d27-344a9b1677a6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19574223 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5119.3594" y="4317.75"/> <port id="pr_7a641519-1b5e-4889-9d27-344a9b1677a6_p1" x="5124.3594" y="4307.75"/> <port id="pr_7a641519-1b5e-4889-9d27-344a9b1677a6_p2" x="5124.3594" y="4337.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_e6f035e7-9cd6-4eb1-ad55-f2e3d43ba1f1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19574223 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5228.2207" y="4314.75"/> <port id="pr_e6f035e7-9cd6-4eb1-ad55-f2e3d43ba1f1_p1" x="5233.2207" y="4304.75"/> <port id="pr_e6f035e7-9cd6-4eb1-ad55-f2e3d43ba1f1_p2" x="5233.2207" y="4334.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_61e3d195-0a13-46e4-9280-702c8d0064d8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19574223 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5339.8936" y="4313.25"/> <port id="pr_61e3d195-0a13-46e4-9280-702c8d0064d8_p1" x="5344.8936" y="4303.25"/> <port id="pr_61e3d195-0a13-46e4-9280-702c8d0064d8_p2" x="5344.8936" y="4333.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8052db6a-b534-4645-8712-2c64ba46bd7a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11124803 PMID:12459251 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5870.0" y="3220.75"/> <port id="pr_8052db6a-b534-4645-8712-2c64ba46bd7a_p1" x="5860.0" y="3225.75"/> <port id="pr_8052db6a-b534-4645-8712-2c64ba46bd7a_p2" x="5890.0" y="3225.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_eabb9137-f780-43a4-90e4-a41c32354037"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11124803 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6216.75" y="3088.475"/> <port id="pr_eabb9137-f780-43a4-90e4-a41c32354037_p1" x="6236.75" y="3093.475"/> <port id="pr_eabb9137-f780-43a4-90e4-a41c32354037_p2" x="6206.75" y="3093.475"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_aecca330-c69c-4f63-b573-41185d99753c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11124803 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6440.5" y="3136.1533"/> <port id="pr_aecca330-c69c-4f63-b573-41185d99753c_p1" x="6430.5" y="3141.1533"/> <port id="pr_aecca330-c69c-4f63-b573-41185d99753c_p2" x="6460.5" y="3141.1533"/> </glyph> <glyph class="process" orientation="vertical" id="pr_dc281118-a699-4028-979a-7f821ab4878c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11124803 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6659.25" y="3040.5"/> <port id="pr_dc281118-a699-4028-979a-7f821ab4878c_p1" x="6664.25" y="3060.5"/> <port id="pr_dc281118-a699-4028-979a-7f821ab4878c_p2" x="6664.25" y="3030.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_e820509f-ee5d-4f42-b400-4dda064cade0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18006823 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6122.0" y="3307.5"/> <port id="pr_e820509f-ee5d-4f42-b400-4dda064cade0_p1" x="6112.0" y="3312.5"/> <port id="pr_e820509f-ee5d-4f42-b400-4dda064cade0_p2" x="6142.0" y="3312.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9aaf5d69-a16d-4cdc-81ec-5b38691b1b43"> <bbox w="10.0" h="10.0" x="6021.5" y="3845.0"/> <port id="pr_9aaf5d69-a16d-4cdc-81ec-5b38691b1b43_p1" x="6041.5" y="3850.0"/> <port id="pr_9aaf5d69-a16d-4cdc-81ec-5b38691b1b43_p2" x="6011.5" y="3850.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_28ba469a-39f3-45d2-b86c-87d17fa051a4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:11756412 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6167.2563" y="3968.5"/> <port id="pr_28ba469a-39f3-45d2-b86c-87d17fa051a4_p1" x="6172.2563" y="3958.5"/> <port id="pr_28ba469a-39f3-45d2-b86c-87d17fa051a4_p2" x="6172.2563" y="3988.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_fd22c8f3-ae9b-4f82-bd64-c556f8b0eca1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11463845 PMID:11756412 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6299.75" y="3799.0"/> <port id="pr_fd22c8f3-ae9b-4f82-bd64-c556f8b0eca1_p1" x="6304.75" y="3819.0"/> <port id="pr_fd22c8f3-ae9b-4f82-bd64-c556f8b0eca1_p2" x="6304.75" y="3789.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f6be19dd-f2df-45db-8fdc-1812331f21b1"> <bbox w="10.0" h="10.0" x="6541.25" y="3779.5"/> <port id="pr_f6be19dd-f2df-45db-8fdc-1812331f21b1_p1" x="6561.25" y="3784.5"/> <port id="pr_f6be19dd-f2df-45db-8fdc-1812331f21b1_p2" x="6531.25" y="3784.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5c22f74a-c6d4-48fa-a12a-403ff2845b12"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11756412 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6300.0" y="3697.0"/> <port id="pr_5c22f74a-c6d4-48fa-a12a-403ff2845b12_p1" x="6305.0" y="3717.0"/> <port id="pr_5c22f74a-c6d4-48fa-a12a-403ff2845b12_p2" x="6305.0" y="3687.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d22e38e3-d79a-4018-9567-bd1240851976"> <bbox w="10.0" h="10.0" x="6435.5" y="3514.5842"/> <port id="pr_d22e38e3-d79a-4018-9567-bd1240851976_p1" x="6425.5" y="3519.5842"/> <port id="pr_d22e38e3-d79a-4018-9567-bd1240851976_p2" x="6455.5" y="3519.5842"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5b94627f-3925-488b-ab73-6aacb8b4302c"> <bbox w="10.0" h="10.0" x="5950.25" y="3206.5"/> <port id="pr_5b94627f-3925-488b-ab73-6aacb8b4302c_p1" x="5970.25" y="3211.5"/> <port id="pr_5b94627f-3925-488b-ab73-6aacb8b4302c_p2" x="5940.25" y="3211.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d0db1419-b30f-4d94-9374-100521b166a1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19440234 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6082.75" y="4046.0"/> <port id="pr_d0db1419-b30f-4d94-9374-100521b166a1_p1" x="6102.75" y="4051.0"/> <port id="pr_d0db1419-b30f-4d94-9374-100521b166a1_p2" x="6072.75" y="4051.0"/> </glyph> <glyph class="and" orientation="vertical" id="logicglyph_f83782e3-900e-4ed9-91d4-208f5c780533"> <bbox w="20.0" h="20.0" x="5940.5" y="3720.25"/> <port id="logicglyph_f83782e3-900e-4ed9-91d4-208f5c780533_p1" x="5950.5" y="3710.25"/> <port id="logicglyph_f83782e3-900e-4ed9-91d4-208f5c780533_p2" x="5950.5" y="3750.25"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_586de639-3bc3-4bed-9f8e-76d779d8def2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10753867 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6476.0" y="4522.0"/> <port id="pr_586de639-3bc3-4bed-9f8e-76d779d8def2_p1" x="6466.0" y="4527.0"/> <port id="pr_586de639-3bc3-4bed-9f8e-76d779d8def2_p2" x="6496.0" y="4527.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_fb6234b2-ca48-4ff2-96c4-bba08f4b6fc4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:9829964 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6107.125" y="4500.0"/> <port id="pr_fb6234b2-ca48-4ff2-96c4-bba08f4b6fc4_p1" x="6097.125" y="4505.0"/> <port id="pr_fb6234b2-ca48-4ff2-96c4-bba08f4b6fc4_p2" x="6127.125" y="4505.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5fdc7856-43d3-402b-a5ee-1db4ee74b22a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:9829964 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6239.5" y="4489.5"/> <port id="pr_5fdc7856-43d3-402b-a5ee-1db4ee74b22a_p1" x="6244.5" y="4509.5"/> <port id="pr_5fdc7856-43d3-402b-a5ee-1db4ee74b22a_p2" x="6244.5" y="4479.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_402dbc17-afe2-4d47-8399-635d4c8446bd"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10454566 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6476.0" y="4473.0"/> <port id="pr_402dbc17-afe2-4d47-8399-635d4c8446bd_p1" x="6466.0" y="4478.0"/> <port id="pr_402dbc17-afe2-4d47-8399-635d4c8446bd_p2" x="6496.0" y="4478.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_3e4c7823-57f4-407d-b489-f7bec3f605ec"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18199536 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="4921.5" y="4390.0"/> <port id="pr_3e4c7823-57f4-407d-b489-f7bec3f605ec_p1" x="4911.5" y="4395.0"/> <port id="pr_3e4c7823-57f4-407d-b489-f7bec3f605ec_p2" x="4941.5" y="4395.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_71eb81d0-2120-4ced-956a-43efd4f58234"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:20580290 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6475.949" y="4084.25"/> <port id="pr_71eb81d0-2120-4ced-956a-43efd4f58234_p1" x="6480.949" y="4104.25"/> <port id="pr_71eb81d0-2120-4ced-956a-43efd4f58234_p2" x="6480.949" y="4074.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ee8711f4-903c-47d0-97ca-657433f37ae3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:21505104 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="6334.2676" y="4082.4062"/> <port id="pr_ee8711f4-903c-47d0-97ca-657433f37ae3_p1" x="6339.2676" y="4102.4062"/> <port id="pr_ee8711f4-903c-47d0-97ca-657433f37ae3_p2" x="6339.2676" y="4072.4062"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ded0aaa4-bafe-4e79-8191-25fa132e0be3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:PI3K_AKT_MTOR Maps_Modules_end References_begin: PMID:17646672 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="5570.75" y="4108.5"/> <port id="pr_ded0aaa4-bafe-4e79-8191-25fa132e0be3_p1" x="5590.75" y="4113.5"/> <port id="pr_ded0aaa4-bafe-4e79-8191-25fa132e0be3_p2" x="5560.75" y="4113.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_581426cc-480d-47fe-960b-c1916a757908"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:21506126 PAR1 can induce AKT phosphorylation; exact mechanism unknown also wich residues are unknown PMID:17374729 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7992.25" y="528.0"/> <port id="pr_581426cc-480d-47fe-960b-c1916a757908_p1" x="7982.25" y="533.0"/> <port id="pr_581426cc-480d-47fe-960b-c1916a757908_p2" x="8012.25" y="533.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_25882ea0-cfac-4cf9-87a5-38f5f84db37a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:21506126 Phosphorylation of beta-catenin is through an indirect mechanism which is unknown PMID:21303971 Path to phosphorylation of b-catenin is not completely depicted here. For full paths see AKT-MODULE References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8167.0" y="528.0"/> <port id="pr_25882ea0-cfac-4cf9-87a5-38f5f84db37a_p1" x="8172.0" y="518.0"/> <port id="pr_25882ea0-cfac-4cf9-87a5-38f5f84db37a_p2" x="8172.0" y="548.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_33ede13b-c54a-45e6-9601-b2b3229b2ab3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:21506126 This phosphorylated of b-catenin bypasses the canonical wnt-MODULE and enters directly the nucleus where it is transcriptionally active PMID:16476742 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8167.0" y="826.54895"/> <port id="pr_33ede13b-c54a-45e6-9601-b2b3229b2ab3_p1" x="8172.0" y="816.54895"/> <port id="pr_33ede13b-c54a-45e6-9601-b2b3229b2ab3_p2" x="8172.0" y="846.54895"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_0df6b883-d534-49e1-8ea5-a6dcd8d0e32a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PAR1 is activated by cleavage of exodomain at Arg41-Ser42 PMID:14652070 PAR1 can be activated by MMP1 PMID:15707890 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7379.5" y="293.5"/> <port id="pr_0df6b883-d534-49e1-8ea5-a6dcd8d0e32a_p1" x="7369.5" y="298.5"/> <port id="pr_0df6b883-d534-49e1-8ea5-a6dcd8d0e32a_p2" x="7399.5" y="298.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9e2c43e1-972f-483d-b4ae-5b4181ef5b6b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11694535 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7594.75" y="293.5"/> <port id="pr_9e2c43e1-972f-483d-b4ae-5b4181ef5b6b_p1" x="7584.75" y="298.5"/> <port id="pr_9e2c43e1-972f-483d-b4ae-5b4181ef5b6b_p2" x="7614.75" y="298.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_aea07624-514c-40f0-b697-cde3d4a8cc2a"> <bbox w="10.0" h="10.0" x="7797.625" y="293.57617"/> <port id="pr_aea07624-514c-40f0-b697-cde3d4a8cc2a_p1" x="7787.625" y="298.57617"/> <port id="pr_aea07624-514c-40f0-b697-cde3d4a8cc2a_p2" x="7817.625" y="298.57617"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a26866ec-1c9c-4350-a159-47fec14f8dbb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20223821 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7629.1875" y="549.02374"/> <port id="pr_a26866ec-1c9c-4350-a159-47fec14f8dbb_p1" x="7649.1875" y="554.02374"/> <port id="pr_a26866ec-1c9c-4350-a159-47fec14f8dbb_p2" x="7619.1875" y="554.02374"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ff79e8ea-ca90-4b74-a002-59423a8fb396"> <bbox w="10.0" h="10.0" x="7333.75" y="560.0"/> <port id="pr_ff79e8ea-ca90-4b74-a002-59423a8fb396_p1" x="7353.75" y="565.0"/> <port id="pr_ff79e8ea-ca90-4b74-a002-59423a8fb396_p2" x="7323.75" y="565.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_fd50b087-3c9d-42d2-addc-56c234e4bdeb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20223821 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7807.75" y="640.0"/> <port id="pr_fd50b087-3c9d-42d2-addc-56c234e4bdeb_p1" x="7812.75" y="660.0"/> <port id="pr_fd50b087-3c9d-42d2-addc-56c234e4bdeb_p2" x="7812.75" y="630.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_915ba5d5-dc4a-4361-8484-738621b9e170"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:21303971 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8167.0" y="668.5"/> <port id="pr_915ba5d5-dc4a-4361-8484-738621b9e170_p1" x="8172.0" y="658.5"/> <port id="pr_915ba5d5-dc4a-4361-8484-738621b9e170_p2" x="8172.0" y="688.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_728d061c-27ff-4f80-84e9-fe3dce2f166d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:21693646 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8144.75" y="281.0"/> <port id="pr_728d061c-27ff-4f80-84e9-fe3dce2f166d_p1" x="8134.75" y="286.0"/> <port id="pr_728d061c-27ff-4f80-84e9-fe3dce2f166d_p2" x="8164.75" y="286.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_32342526-98b0-4d5d-b4c4-741c482e0c99"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:21727895 PMID:21909076 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8430.017" y="395.00098"/> <port id="pr_32342526-98b0-4d5d-b4c4-741c482e0c99_p1" x="8435.017" y="415.00098"/> <port id="pr_32342526-98b0-4d5d-b4c4-741c482e0c99_p2" x="8435.017" y="385.00098"/> </glyph> <glyph class="omitted process" orientation="vertical" id="pr_12d345af-1941-49c3-9f82-6dc25005d4f0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Association of LGR5 w/ Wnt-receptors leads to synergistic TOPFLASH reporter activity PMID:21727895 LGR5 antagonises Wnt signalling PMID:21829496 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8736.5" y="439.25"/> <port id="pr_12d345af-1941-49c3-9f82-6dc25005d4f0_p1" x="8741.5" y="429.25"/> <port id="pr_12d345af-1941-49c3-9f82-6dc25005d4f0_p2" x="8741.5" y="459.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_af37ddf2-dcc6-4d6d-83a2-992243eaf42c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Only the Galpha_q subunit can activate PLC-beta PMID:11395409 PMID:19359428 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7332.5" y="715.0514"/> <port id="pr_af37ddf2-dcc6-4d6d-83a2-992243eaf42c_p1" x="7352.5" y="720.0514"/> <port id="pr_af37ddf2-dcc6-4d6d-83a2-992243eaf42c_p2" x="7322.5" y="720.0514"/> </glyph> <glyph class="process" orientation="vertical" id="pr_d2ddea26-2a08-4d75-9ac6-804a7182afcb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:9859994 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7913.0" y="661.5"/> <port id="pr_d2ddea26-2a08-4d75-9ac6-804a7182afcb_p1" x="7918.0" y="651.5"/> <port id="pr_d2ddea26-2a08-4d75-9ac6-804a7182afcb_p2" x="7918.0" y="681.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1f6cc78a-a7c8-4944-976c-6aad890a3121"> <bbox w="10.0" h="10.0" x="7913.5" y="849.0"/> <port id="pr_1f6cc78a-a7c8-4944-976c-6aad890a3121_p1" x="7918.5" y="839.0"/> <port id="pr_1f6cc78a-a7c8-4944-976c-6aad890a3121_p2" x="7918.5" y="869.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_b21af477-9737-4d7c-9b87-7b51d9098d12"> <bbox w="10.0" h="10.0" x="7688.875" y="782.11646"/> <port id="pr_b21af477-9737-4d7c-9b87-7b51d9098d12_p1" x="7678.875" y="787.11646"/> <port id="pr_b21af477-9737-4d7c-9b87-7b51d9098d12_p2" x="7708.875" y="787.11646"/> </glyph> <glyph class="process" orientation="vertical" id="pr_134aa9ce-0abb-4ade-a655-88cf010ca847"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16054198 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7389.0" y="780.71875"/> <port id="pr_134aa9ce-0abb-4ade-a655-88cf010ca847_p1" x="7394.0" y="770.71875"/> <port id="pr_134aa9ce-0abb-4ade-a655-88cf010ca847_p2" x="7394.0" y="800.71875"/> </glyph> <glyph class="process" orientation="vertical" id="pr_2a539c7d-3b14-44d6-8c1a-742b003fbeb7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12747838 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7584.0" y="916.25"/> <port id="pr_2a539c7d-3b14-44d6-8c1a-742b003fbeb7_p1" x="7589.0" y="936.25"/> <port id="pr_2a539c7d-3b14-44d6-8c1a-742b003fbeb7_p2" x="7589.0" y="906.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1d4896f9-4e4d-4d0a-98e3-e0f839ab068a"> <bbox w="10.0" h="10.0" x="7412.5" y="944.3269"/> <port id="pr_1d4896f9-4e4d-4d0a-98e3-e0f839ab068a_p1" x="7417.5" y="964.3269"/> <port id="pr_1d4896f9-4e4d-4d0a-98e3-e0f839ab068a_p2" x="7417.5" y="934.3269"/> </glyph> <glyph class="process" orientation="vertical" id="pr_4d789028-e74a-440f-a2d5-3e78e521d7d5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12747838 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7465.5" y="1035.2031"/> <port id="pr_4d789028-e74a-440f-a2d5-3e78e521d7d5_p1" x="7470.5" y="1025.2031"/> <port id="pr_4d789028-e74a-440f-a2d5-3e78e521d7d5_p2" x="7470.5" y="1055.2031"/> </glyph> <glyph class="process" orientation="vertical" id="pr_67e2ce6a-f110-4925-b78c-cef67b15b5dc"> <bbox w="10.0" h="10.0" x="7784.75" y="900.5"/> <port id="pr_67e2ce6a-f110-4925-b78c-cef67b15b5dc_p1" x="7789.75" y="890.5"/> <port id="pr_67e2ce6a-f110-4925-b78c-cef67b15b5dc_p2" x="7789.75" y="920.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_01c1c2c2-747f-4d65-8650-2dcdb42e9b46"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:21736902 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7822.625" y="1025.3889"/> <port id="pr_01c1c2c2-747f-4d65-8650-2dcdb42e9b46_p1" x="7812.625" y="1030.3889"/> <port id="pr_01c1c2c2-747f-4d65-8650-2dcdb42e9b46_p2" x="7842.625" y="1030.3889"/> </glyph> <glyph class="process" orientation="vertical" id="pr_92994762-12fe-430a-9aac-a0ec54ccdee1"> <bbox w="10.0" h="10.0" x="7897.009" y="934.5"/> <port id="pr_92994762-12fe-430a-9aac-a0ec54ccdee1_p1" x="7902.009" y="954.5"/> <port id="pr_92994762-12fe-430a-9aac-a0ec54ccdee1_p2" x="7902.009" y="924.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_14016a51-9638-430c-9151-724452c8974f"> <bbox w="10.0" h="10.0" x="7197.0" y="1205.0"/> <port id="pr_14016a51-9638-430c-9151-724452c8974f_p1" x="7202.0" y="1195.0"/> <port id="pr_14016a51-9638-430c-9151-724452c8974f_p2" x="7202.0" y="1225.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_102094c1-7b1b-40a3-adc4-1833766a00cc"> <bbox w="10.0" h="10.0" x="7432.0" y="1205.0"/> <port id="pr_102094c1-7b1b-40a3-adc4-1833766a00cc_p1" x="7452.0" y="1210.0"/> <port id="pr_102094c1-7b1b-40a3-adc4-1833766a00cc_p2" x="7422.0" y="1210.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_634b2783-3226-464f-9ea8-18a834c38d39"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16054021 PMID:18372913 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7137.0" y="1337.0"/> <port id="pr_634b2783-3226-464f-9ea8-18a834c38d39_p1" x="7157.0" y="1342.0"/> <port id="pr_634b2783-3226-464f-9ea8-18a834c38d39_p2" x="7127.0" y="1342.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_cbae4977-d67e-4b01-9cd4-1a2169daf25d"> <bbox w="10.0" h="10.0" x="7574.4956" y="1249.0"/> <port id="pr_cbae4977-d67e-4b01-9cd4-1a2169daf25d_p1" x="7579.4956" y="1269.0"/> <port id="pr_cbae4977-d67e-4b01-9cd4-1a2169daf25d_p2" x="7579.4956" y="1239.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_cd7fb350-582b-4518-ac2d-20100a92e85c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18372913 PAR1 activates EGFR PMID:16525676 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7140.333" y="1469.5739"/> <port id="pr_cd7fb350-582b-4518-ac2d-20100a92e85c_p1" x="7130.333" y="1474.5739"/> <port id="pr_cd7fb350-582b-4518-ac2d-20100a92e85c_p2" x="7160.333" y="1474.5739"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1f58e1d3-69b2-45a8-af49-c7119dd5a44d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:21406690 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9295.105" y="402.92188"/> <port id="pr_1f58e1d3-69b2-45a8-af49-c7119dd5a44d_p1" x="9300.105" y="422.92188"/> <port id="pr_1f58e1d3-69b2-45a8-af49-c7119dd5a44d_p2" x="9300.105" y="392.92188"/> </glyph> <glyph class="process" orientation="vertical" id="pr_05aee189-ba29-4a6c-b8b3-bfb1e26bc258"> <bbox w="10.0" h="10.0" x="9081.443" y="205.07812"/> <port id="pr_05aee189-ba29-4a6c-b8b3-bfb1e26bc258_p1" x="9086.443" y="195.07812"/> <port id="pr_05aee189-ba29-4a6c-b8b3-bfb1e26bc258_p2" x="9086.443" y="225.07812"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_89d20e6e-755f-4c0b-8a68-35baf0e31c00"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:9228084 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9412.5" y="657.5"/> <port id="pr_89d20e6e-755f-4c0b-8a68-35baf0e31c00_p1" x="9432.5" y="662.5"/> <port id="pr_89d20e6e-755f-4c0b-8a68-35baf0e31c00_p2" x="9402.5" y="662.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_0fc603b2-f2b2-4282-be1c-bb959ef2c42a"> <bbox w="10.0" h="10.0" x="9091.59" y="383.34375"/> <port id="pr_0fc603b2-f2b2-4282-be1c-bb959ef2c42a_p1" x="9096.59" y="373.34375"/> <port id="pr_0fc603b2-f2b2-4282-be1c-bb959ef2c42a_p2" x="9096.59" y="403.34375"/> </glyph> <glyph class="omitted process" orientation="vertical" id="pr_e5b2e874-c62d-43bf-b739-701544741530"> <bbox w="10.0" h="10.0" x="9137.0" y="655.0"/> <port id="pr_e5b2e874-c62d-43bf-b739-701544741530_p1" x="9142.0" y="645.0"/> <port id="pr_e5b2e874-c62d-43bf-b739-701544741530_p2" x="9142.0" y="675.0"/> </glyph> <glyph class="omitted process" orientation="vertical" id="pr_3e9841d1-e84a-4924-90b7-cbc15acb8578"> <bbox w="10.0" h="10.0" x="8953.0" y="737.5"/> <port id="pr_3e9841d1-e84a-4924-90b7-cbc15acb8578_p1" x="8958.0" y="757.5"/> <port id="pr_3e9841d1-e84a-4924-90b7-cbc15acb8578_p2" x="8958.0" y="727.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_418f4656-efc5-4138-bd45-1cc6899fd9a4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PKA phosphorylates first Thr1548? followed by GSK3 at S1544 PMID:21406690 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9568.369" y="449.0"/> <port id="pr_418f4656-efc5-4138-bd45-1cc6899fd9a4_p1" x="9573.369" y="439.0"/> <port id="pr_418f4656-efc5-4138-bd45-1cc6899fd9a4_p2" x="9573.369" y="469.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_7c34e562-bee4-41cb-b3c6-977c50a31392"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:21406690 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9386.75" y="545.25885"/> <port id="pr_7c34e562-bee4-41cb-b3c6-977c50a31392_p1" x="9376.75" y="550.25885"/> <port id="pr_7c34e562-bee4-41cb-b3c6-977c50a31392_p2" x="9406.75" y="550.25885"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_7181f536-9a4b-430b-a836-f925544fcb9c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:21406690 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9350.75" y="535.1945"/> <port id="pr_7181f536-9a4b-430b-a836-f925544fcb9c_p1" x="9370.75" y="540.1945"/> <port id="pr_7181f536-9a4b-430b-a836-f925544fcb9c_p2" x="9340.75" y="540.1945"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d51ef16b-cd68-484d-b7f2-cd00e1c15604"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:21237163 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9510.625" y="758.50604"/> <port id="pr_d51ef16b-cd68-484d-b7f2-cd00e1c15604_p1" x="9500.625" y="763.50604"/> <port id="pr_d51ef16b-cd68-484d-b7f2-cd00e1c15604_p2" x="9530.625" y="763.50604"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_b6653469-c1b8-4cba-a8ca-303d9848c5e5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:21237163 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9141.848" y="674.5"/> <port id="pr_b6653469-c1b8-4cba-a8ca-303d9848c5e5_p1" x="9161.848" y="679.5"/> <port id="pr_b6653469-c1b8-4cba-a8ca-303d9848c5e5_p2" x="9131.848" y="679.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ec672bd5-35af-46b0-9176-13cf29178a2c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20628572 PMID:12839624 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9556.797" y="1054.5"/> <port id="pr_ec672bd5-35af-46b0-9176-13cf29178a2c_p1" x="9561.797" y="1044.5"/> <port id="pr_ec672bd5-35af-46b0-9176-13cf29178a2c_p2" x="9561.797" y="1074.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_02ee599f-4c20-490d-90d2-6ae9c4dadc92"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20628572 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9430.5" y="1121.6895"/> <port id="pr_02ee599f-4c20-490d-90d2-6ae9c4dadc92_p1" x="9450.5" y="1126.6895"/> <port id="pr_02ee599f-4c20-490d-90d2-6ae9c4dadc92_p2" x="9420.5" y="1126.6895"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1f8aaf0f-abcd-403d-8c50-b7757f63b6e4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20628572 RGS3 and RGS14 are GTP-ase activating proteins for Gi_alpha and Gq_alpha. PMID:10999941 PMID:12534294 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9197.0" y="1106.25"/> <port id="pr_1f8aaf0f-abcd-403d-8c50-b7757f63b6e4_p1" x="9202.0" y="1126.25"/> <port id="pr_1f8aaf0f-abcd-403d-8c50-b7757f63b6e4_p2" x="9202.0" y="1096.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ce0fde21-eaa2-4612-8e48-eae58dff7f75"> <bbox w="10.0" h="10.0" x="8510.5" y="814.0"/> <port id="pr_ce0fde21-eaa2-4612-8e48-eae58dff7f75_p1" x="8530.5" y="819.0"/> <port id="pr_ce0fde21-eaa2-4612-8e48-eae58dff7f75_p2" x="8500.5" y="819.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f45080f4-3bfc-48cb-be34-59a32b0c7a8b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10999941 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8969.594" y="445.0"/> <port id="pr_f45080f4-3bfc-48cb-be34-59a32b0c7a8b_p1" x="8959.594" y="450.0"/> <port id="pr_f45080f4-3bfc-48cb-be34-59a32b0c7a8b_p2" x="8989.594" y="450.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a2c796dc-e73f-4efe-8701-0722350ee0e4"> <bbox w="10.0" h="10.0" x="9096.0" y="1060.5"/> <port id="pr_a2c796dc-e73f-4efe-8701-0722350ee0e4_p1" x="9101.0" y="1080.5"/> <port id="pr_a2c796dc-e73f-4efe-8701-0722350ee0e4_p2" x="9101.0" y="1050.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_cf3ee625-8b29-4af0-8965-3ba525256afd"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20347994 PMID:10862767 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9097.0" y="920.5"/> <port id="pr_cf3ee625-8b29-4af0-8965-3ba525256afd_p1" x="9102.0" y="940.5"/> <port id="pr_cf3ee625-8b29-4af0-8965-3ba525256afd_p2" x="9102.0" y="910.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a126cfa1-1eeb-4087-89f8-5d36119c70c6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PLC-beta_2 and 3 are activated by the beta-and gamma subunit of the G-protein class q PMID:20553968 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7402.5" y="788.36804"/> <port id="pr_a126cfa1-1eeb-4087-89f8-5d36119c70c6_p1" x="7422.5" y="793.36804"/> <port id="pr_a126cfa1-1eeb-4087-89f8-5d36119c70c6_p2" x="7392.5" y="793.36804"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1e0d86e5-91ac-4da3-9436-051f568c3f77"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16402909 PMID:12657629 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7291.5117" y="865.25"/> <port id="pr_1e0d86e5-91ac-4da3-9436-051f568c3f77_p1" x="7296.5117" y="855.25"/> <port id="pr_1e0d86e5-91ac-4da3-9436-051f568c3f77_p2" x="7296.5117" y="885.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_eab79457-d8ad-4a1c-9299-9c65af664f8a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Cthrc1 enhances formation of Wnt-Fzl-Ror2 complex PMID:12839624 PMID:18606138 Syndecan-4 binds to Fzl, Dvl and is required for PCP MODULE. PMID:16604063 PMID:21397842 Vangl-2 forms complex upon binding with Wnt-5 PMID:21316585 ROR2 is associated with Wnt, Fzl and CK1_epsilon PMID:20215527 PPR binds to Fzl in both canonical and non-canonical MODULE PMID:20093472 PMID:21380625 PMID:20579883 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9474.133" y="1547.0"/> <port id="pr_eab79457-d8ad-4a1c-9299-9c65af664f8a_p1" x="9479.133" y="1537.0"/> <port id="pr_eab79457-d8ad-4a1c-9299-9c65af664f8a_p2" x="9479.133" y="1567.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_fcc832e6-ffde-4e25-80f1-93820e806f67"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: For the Fzl receptor, probably same mechanism as for the canonical MODULE. CK1 epsilon is activated upon Wnt-5 stimulation, however, the mechanism is unknown. PMID:17244647 PMID:20215527 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9466.959" y="1762.5"/> <port id="pr_fcc832e6-ffde-4e25-80f1-93820e806f67_p1" x="9471.959" y="1752.5"/> <port id="pr_fcc832e6-ffde-4e25-80f1-93820e806f67_p2" x="9471.959" y="1782.5"/> </glyph> <glyph class="omitted process" orientation="vertical" id="pr_014b210f-de8c-45b3-a695-94ffd545951c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Active PKC phosphorylates Dvl, just not enough to achieve the PS-form. PMID:12958364 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9213.0" y="1905.0"/> <port id="pr_014b210f-de8c-45b3-a695-94ffd545951c_p1" x="9218.0" y="1895.0"/> <port id="pr_014b210f-de8c-45b3-a695-94ffd545951c_p2" x="9218.0" y="1925.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_3002034b-55e7-4355-beee-96dbaaf003c1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Polymerisation of Dvl-proteins is not associated with endosomes or other vesicles. Polymerization of Dvl acts as scaffold for recruiting Rac1 PMID:20457807 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9467.272" y="2046.6631"/> <port id="pr_3002034b-55e7-4355-beee-96dbaaf003c1_p1" x="9472.272" y="2036.6631"/> <port id="pr_3002034b-55e7-4355-beee-96dbaaf003c1_p2" x="9472.272" y="2066.663"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a178de00-1d7f-4779-bfc8-7794defe12e5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:12958364 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9148.0" y="2008.8724"/> <port id="pr_a178de00-1d7f-4779-bfc8-7794defe12e5_p1" x="9153.0" y="1998.8724"/> <port id="pr_a178de00-1d7f-4779-bfc8-7794defe12e5_p2" x="9153.0" y="2028.8724"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5d085f47-5842-45d4-8177-b55c27a7ab32"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19966784 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8300.0" y="1191.0"/> <port id="pr_5d085f47-5842-45d4-8177-b55c27a7ab32_p1" x="8290.0" y="1196.0"/> <port id="pr_5d085f47-5842-45d4-8177-b55c27a7ab32_p2" x="8320.0" y="1196.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_3819ccd2-dff9-4b60-8740-cbda7edf990e"> <bbox w="10.0" h="10.0" x="8670.25" y="1262.5"/> <port id="pr_3819ccd2-dff9-4b60-8740-cbda7edf990e_p1" x="8660.25" y="1267.5"/> <port id="pr_3819ccd2-dff9-4b60-8740-cbda7edf990e_p2" x="8690.25" y="1267.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d1ec1bf8-9193-4b6c-801e-da4437e42a0f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:21078818 PMID:15375164 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7706.125" y="2489.75"/> <port id="pr_d1ec1bf8-9193-4b6c-801e-da4437e42a0f_p1" x="7726.125" y="2494.75"/> <port id="pr_d1ec1bf8-9193-4b6c-801e-da4437e42a0f_p2" x="7696.125" y="2494.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_e376a36a-a7e3-43ea-9363-bd3c6d48827b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: CK1 delta phosphorylates residues in cluster I: S84, S82, S79, T71 and in cluster II: S5, S8, S11, S14, S17, S20. Note: Experiments were performed in Xenopus PMID:21316585 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7493.25" y="2361.0"/> <port id="pr_e376a36a-a7e3-43ea-9363-bd3c6d48827b_p1" x="7498.25" y="2381.0"/> <port id="pr_e376a36a-a7e3-43ea-9363-bd3c6d48827b_p2" x="7498.25" y="2351.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_f69e3856-e73a-4676-b8ae-f576e110c535"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:22037766 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9039.25" y="1443.5"/> <port id="pr_f69e3856-e73a-4676-b8ae-f576e110c535_p1" x="9044.25" y="1433.5"/> <port id="pr_f69e3856-e73a-4676-b8ae-f576e110c535_p2" x="9044.25" y="1463.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_3445c5e2-3e66-46c2-bd49-5d116a04435e"> <bbox w="10.0" h="10.0" x="8858.413" y="2015.0"/> <port id="pr_3445c5e2-3e66-46c2-bd49-5d116a04435e_p1" x="8863.413" y="2035.0"/> <port id="pr_3445c5e2-3e66-46c2-bd49-5d116a04435e_p2" x="8863.413" y="2005.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_df7b667c-a532-4336-991d-6ae0bc80393b"> <bbox w="10.0" h="10.0" x="8647.875" y="1971.7096"/> <port id="pr_df7b667c-a532-4336-991d-6ae0bc80393b_p1" x="8667.875" y="1976.7096"/> <port id="pr_df7b667c-a532-4336-991d-6ae0bc80393b_p2" x="8637.875" y="1976.7096"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_03c530fa-db0f-4fe0-8f4e-f2e9d580f0bc"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Prickle interacts physically with Vangl PMID:22037766 PMID:12941693 Par6 is constitutively associated with Dvl PMID:19379695 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9178.0" y="1290.9004"/> <port id="pr_03c530fa-db0f-4fe0-8f4e-f2e9d580f0bc_p1" x="9168.0" y="1295.9004"/> <port id="pr_03c530fa-db0f-4fe0-8f4e-f2e9d580f0bc_p2" x="9198.0" y="1295.9004"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a6c60ea8-25f3-4758-b6de-06134f3d30b9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17030191 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9173.0" y="2153.75"/> <port id="pr_a6c60ea8-25f3-4758-b6de-06134f3d30b9_p1" x="9193.0" y="2158.75"/> <port id="pr_a6c60ea8-25f3-4758-b6de-06134f3d30b9_p2" x="9163.0" y="2158.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_0248f657-bdd9-4ad8-bc07-e2f991fde4c8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Smurf associates upon binding of Wnt5 to frizzled PMID:19379695 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9463.138" y="2321.25"/> <port id="pr_0248f657-bdd9-4ad8-bc07-e2f991fde4c8_p1" x="9468.138" y="2311.25"/> <port id="pr_0248f657-bdd9-4ad8-bc07-e2f991fde4c8_p2" x="9468.138" y="2341.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_630c462a-bd88-4437-8388-1824f027c515"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Ubiquitination of Prickle by Smurf PMID:19379695 PMID:20930545 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9434.25" y="2608.75"/> <port id="pr_630c462a-bd88-4437-8388-1824f027c515_p1" x="9439.25" y="2598.75"/> <port id="pr_630c462a-bd88-4437-8388-1824f027c515_p2" x="9439.25" y="2628.75"/> </glyph> <glyph class="omitted process" orientation="vertical" id="pr_1dea90e5-343b-43ad-9f49-cfb1f7e6d158"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19379695 PMID:20930545 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8593.266" y="2090.0"/> <port id="pr_1dea90e5-343b-43ad-9f49-cfb1f7e6d158_p1" x="8598.266" y="2110.0"/> <port id="pr_1dea90e5-343b-43ad-9f49-cfb1f7e6d158_p2" x="8598.266" y="2080.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_010656ec-b365-4c73-8d5e-b6b9d6f3526b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19701191 Dac1 primarly functions in beta-catenin-independent MODULEs PMID:21718540 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8811.0" y="1093.0"/> <port id="pr_010656ec-b365-4c73-8d5e-b6b9d6f3526b_p1" x="8816.0" y="1113.0"/> <port id="pr_010656ec-b365-4c73-8d5e-b6b9d6f3526b_p2" x="8816.0" y="1083.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_cdd536ff-eaa7-421a-ae9c-9d513038286e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:21262972 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8842.25" y="1166.0"/> <port id="pr_cdd536ff-eaa7-421a-ae9c-9d513038286e_p1" x="8847.25" y="1156.0"/> <port id="pr_cdd536ff-eaa7-421a-ae9c-9d513038286e_p2" x="8847.25" y="1186.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_102a3b1f-a05f-4fb6-ae82-6ef2ebe41185"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:21262972 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8718.0" y="1291.8438"/> <port id="pr_102a3b1f-a05f-4fb6-ae82-6ef2ebe41185_p1" x="8723.0" y="1281.8438"/> <port id="pr_102a3b1f-a05f-4fb6-ae82-6ef2ebe41185_p2" x="8723.0" y="1311.8438"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_557587fc-0186-4d9d-a7a8-bb2fd8ca66a6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:16446366 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8881.0" y="1608.0"/> <port id="pr_557587fc-0186-4d9d-a7a8-bb2fd8ca66a6_p1" x="8901.0" y="1613.0"/> <port id="pr_557587fc-0186-4d9d-a7a8-bb2fd8ca66a6_p2" x="8871.0" y="1613.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_22466b7c-e26a-4cf8-871b-8f2e2ef8852a"> <bbox w="10.0" h="10.0" x="8807.154" y="1523.0"/> <port id="pr_22466b7c-e26a-4cf8-871b-8f2e2ef8852a_p1" x="8812.154" y="1543.0"/> <port id="pr_22466b7c-e26a-4cf8-871b-8f2e2ef8852a_p2" x="8812.154" y="1513.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8e153155-d94a-4a00-ba9c-b4e229d526ca"> <bbox w="10.0" h="10.0" x="8952.25" y="2368.5"/> <port id="pr_8e153155-d94a-4a00-ba9c-b4e229d526ca_p1" x="8972.25" y="2373.5"/> <port id="pr_8e153155-d94a-4a00-ba9c-b4e229d526ca_p2" x="8942.25" y="2373.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2bac3b25-8a15-445c-9192-290450a9e82f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Acidification of the endosome is required for transducing the signal. The exact mechanism is unknown except that v-ATPase is involved in the process. PMID:20699474 PMID:21380625 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7891.0" y="1895.0"/> <port id="pr_2bac3b25-8a15-445c-9192-290450a9e82f_p1" x="7881.0" y="1900.0"/> <port id="pr_2bac3b25-8a15-445c-9192-290450a9e82f_p2" x="7911.0" y="1900.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1f0d36f6-19b8-4330-9504-080c888f0274"> <bbox w="10.0" h="10.0" x="7983.0" y="1902.0"/> <port id="pr_1f0d36f6-19b8-4330-9504-080c888f0274_p1" x="7988.0" y="1892.0"/> <port id="pr_1f0d36f6-19b8-4330-9504-080c888f0274_p2" x="7988.0" y="1922.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_9575931d-1120-45b2-8641-ff4745bdf036"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Rac1 found to be associated with polymerised Dvl. PMID:20215527 PMID:18953287 DEP domain in Dvl is enough to activate Rac PMID:12533515 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8340.892" y="1844.25"/> <port id="pr_9575931d-1120-45b2-8641-ff4745bdf036_p1" x="8345.892" y="1864.25"/> <port id="pr_9575931d-1120-45b2-8641-ff4745bdf036_p2" x="8345.892" y="1834.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d0be9214-c2e4-46c4-a75b-4ef6f66ca646"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Polymerised Dvl act as scaffold for recruiting axin. PMID:21078818 GSK3 phosphorylates ROR2 PMID:17986005 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8112.9287" y="2486.4543"/> <port id="pr_d0be9214-c2e4-46c4-a75b-4ef6f66ca646_p1" x="8132.9287" y="2491.4543"/> <port id="pr_d0be9214-c2e4-46c4-a75b-4ef6f66ca646_p2" x="8102.9287" y="2491.4543"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_721a7755-f016-4138-9fcd-11e7291a9afa"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Rspo is required for clathrin-mediated endocytosis PMID:21397842 It has been shown that Dvl polymers are not associated with vesicles, therefore endocytosis of the complex is likely to be after Dvl polymerisation. PMID:16263762 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9023.25" y="2666.6602"/> <port id="pr_721a7755-f016-4138-9fcd-11e7291a9afa_p1" x="9043.25" y="2671.6602"/> <port id="pr_721a7755-f016-4138-9fcd-11e7291a9afa_p2" x="9013.25" y="2671.6602"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a8188b79-cb75-48c9-b212-91b19672f0d4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Clathrin-mediated endocytosis PMID:21397842 PMID:20947020 PMID:19910923 PCP MODULE splits in Rac1 branch when Dvl is not hyper-phosphorylated PMID:18953287 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8449.375" y="2334.25"/> <port id="pr_a8188b79-cb75-48c9-b212-91b19672f0d4_p1" x="8454.375" y="2354.25"/> <port id="pr_a8188b79-cb75-48c9-b212-91b19672f0d4_p2" x="8454.375" y="2324.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_983063ad-581a-4018-b0af-dde727c33012"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Rspo induces clathrin-mediated endocytosis PMID:21397842 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9091.5" y="2473.0"/> <port id="pr_983063ad-581a-4018-b0af-dde727c33012_p1" x="9111.5" y="2478.0"/> <port id="pr_983063ad-581a-4018-b0af-dde727c33012_p2" x="9081.5" y="2478.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_58736388-29de-48bd-bb6c-47b876aaffbb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Clathrin-mediated endocytosis PMID:21397842 PMID:20947020 PMID:19910923 RhoA branch of the PCP -MODULE when Dvl is hyper-phosphorylated by CK_epsilon PMID:18953287 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8537.125" y="2578.25"/> <port id="pr_58736388-29de-48bd-bb6c-47b876aaffbb_p1" x="8542.125" y="2598.25"/> <port id="pr_58736388-29de-48bd-bb6c-47b876aaffbb_p2" x="8542.125" y="2568.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_85dbb3ea-a52a-44c5-8b23-cb71219879ae"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to subunits ATP6V0C/D of the ATPase to lower the pH in the endosome. The reason for this is unknown but it is speculated that a lower pH is required for remodeling of the actin skeleton. However, v-ATPase is necessary for signaling PMID:21796133 PMID:21380625 PMID:20093472 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7800.75" y="2010.25"/> <port id="pr_85dbb3ea-a52a-44c5-8b23-cb71219879ae_p1" x="7805.75" y="2030.25"/> <port id="pr_85dbb3ea-a52a-44c5-8b23-cb71219879ae_p2" x="7805.75" y="2000.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_99a83938-fd48-4430-b3d4-153f6fb8235d"> <bbox w="10.0" h="10.0" x="8156.5" y="1709.2144"/> <port id="pr_99a83938-fd48-4430-b3d4-153f6fb8235d_p1" x="8176.5" y="1714.2144"/> <port id="pr_99a83938-fd48-4430-b3d4-153f6fb8235d_p2" x="8146.5" y="1714.2144"/> </glyph> <glyph class="process" orientation="vertical" id="pr_05bf8b64-4356-48e6-8509-da73ebf66a5e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12514131 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8039.0" y="1471.875"/> <port id="pr_05bf8b64-4356-48e6-8509-da73ebf66a5e_p1" x="8044.0" y="1491.875"/> <port id="pr_05bf8b64-4356-48e6-8509-da73ebf66a5e_p2" x="8044.0" y="1461.875"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_003fef40-38df-4fd0-bc1a-801a10732ed7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Akt phosphorylates POSH in the Rac1 binding domain, preventing binding of Rac1 w/ POSH PMID:17535800 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8176.25" y="1527.5"/> <port id="pr_003fef40-38df-4fd0-bc1a-801a10732ed7_p1" x="8166.25" y="1532.5"/> <port id="pr_003fef40-38df-4fd0-bc1a-801a10732ed7_p2" x="8196.25" y="1532.5"/> </glyph> <glyph class="omitted process" orientation="vertical" id="pr_8ccdda1b-ea41-4b8b-a463-3c7444289779"> <bbox w="10.0" h="10.0" x="8158.7993" y="1209.5"/> <port id="pr_8ccdda1b-ea41-4b8b-a463-3c7444289779_p1" x="8163.7993" y="1229.5"/> <port id="pr_8ccdda1b-ea41-4b8b-a463-3c7444289779_p2" x="8163.7993" y="1199.5"/> </glyph> <glyph class="omitted process" orientation="vertical" id="pr_fa97a298-712a-4414-b6f5-7702252acb7c"> <bbox w="10.0" h="10.0" x="8186.0405" y="1209.5"/> <port id="pr_fa97a298-712a-4414-b6f5-7702252acb7c_p1" x="8191.0405" y="1229.5"/> <port id="pr_fa97a298-712a-4414-b6f5-7702252acb7c_p2" x="8191.0405" y="1199.5"/> </glyph> <glyph class="omitted process" orientation="vertical" id="pr_cf874fed-0b52-4478-aa0b-2424c9ff63f6"> <bbox w="10.0" h="10.0" x="8212.133" y="1209.5"/> <port id="pr_cf874fed-0b52-4478-aa0b-2424c9ff63f6_p1" x="8217.133" y="1229.5"/> <port id="pr_cf874fed-0b52-4478-aa0b-2424c9ff63f6_p2" x="8217.133" y="1199.5"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_dcd36732-2702-40f7-a8bc-d9bb922060c2"> <bbox w="10.0" h="10.0" x="8202.634" y="978.70746"/> <port id="pr_dcd36732-2702-40f7-a8bc-d9bb922060c2_p1" x="8192.634" y="983.70746"/> <port id="pr_dcd36732-2702-40f7-a8bc-d9bb922060c2_p2" x="8222.634" y="983.70746"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_97532967-2155-415d-a08e-0d5fde74010b"> <bbox w="10.0" h="10.0" x="8229.73" y="978.70746"/> <port id="pr_97532967-2155-415d-a08e-0d5fde74010b_p1" x="8219.73" y="983.70746"/> <port id="pr_97532967-2155-415d-a08e-0d5fde74010b_p2" x="8249.73" y="983.70746"/> </glyph> <glyph class="omitted process" orientation="vertical" id="pr_32619d5e-2283-4ef5-aa73-4b20ccb76059"> <bbox w="10.0" h="10.0" x="8256.828" y="978.70746"/> <port id="pr_32619d5e-2283-4ef5-aa73-4b20ccb76059_p1" x="8261.828" y="998.70746"/> <port id="pr_32619d5e-2283-4ef5-aa73-4b20ccb76059_p2" x="8261.828" y="968.70746"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d57a12e3-f4db-476a-88cf-05d46ab165d8"> <bbox w="10.0" h="10.0" x="8261.0" y="974.954"/> <port id="pr_d57a12e3-f4db-476a-88cf-05d46ab165d8_p1" x="8251.0" y="979.954"/> <port id="pr_d57a12e3-f4db-476a-88cf-05d46ab165d8_p2" x="8281.0" y="979.954"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_3b54bf2b-a71d-473d-9317-f173da4571f8"> <bbox w="10.0" h="10.0" x="8261.0" y="993.6381"/> <port id="pr_3b54bf2b-a71d-473d-9317-f173da4571f8_p1" x="8251.0" y="998.6381"/> <port id="pr_3b54bf2b-a71d-473d-9317-f173da4571f8_p2" x="8281.0" y="998.6381"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_b4579f80-1bab-4673-ab29-9e0cab405270"> <bbox w="10.0" h="10.0" x="8260.5" y="1016.528"/> <port id="pr_b4579f80-1bab-4673-ab29-9e0cab405270_p1" x="8250.5" y="1021.528"/> <port id="pr_b4579f80-1bab-4673-ab29-9e0cab405270_p2" x="8280.5" y="1021.528"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a9ddf0f7-d574-4153-9b03-fe093eab4881"> <bbox w="10.0" h="10.0" x="8317.715" y="974.0"/> <port id="pr_a9ddf0f7-d574-4153-9b03-fe093eab4881_p1" x="8307.715" y="979.0"/> <port id="pr_a9ddf0f7-d574-4153-9b03-fe093eab4881_p2" x="8337.715" y="979.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_b7316c25-1757-4f0f-b82d-3e9df901f3d7"> <bbox w="10.0" h="10.0" x="8318.599" y="953.0"/> <port id="pr_b7316c25-1757-4f0f-b82d-3e9df901f3d7_p1" x="8308.599" y="958.0"/> <port id="pr_b7316c25-1757-4f0f-b82d-3e9df901f3d7_p2" x="8338.599" y="958.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d3818d7c-6c4a-40fc-bac8-fb57008594f5"> <bbox w="10.0" h="10.0" x="8265.041" y="953.14856"/> <port id="pr_d3818d7c-6c4a-40fc-bac8-fb57008594f5_p1" x="8255.041" y="958.14856"/> <port id="pr_d3818d7c-6c4a-40fc-bac8-fb57008594f5_p2" x="8285.041" y="958.14856"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_60a58242-f8a9-40f5-9c00-b43be33e3ed5"> <bbox w="10.0" h="10.0" x="8312.0" y="1016.80005"/> <port id="pr_60a58242-f8a9-40f5-9c00-b43be33e3ed5_p1" x="8302.0" y="1021.80005"/> <port id="pr_60a58242-f8a9-40f5-9c00-b43be33e3ed5_p2" x="8332.0" y="1021.80005"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_44a2dde0-7f2b-4e5c-b2d7-6e9fadc8f704"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Acidification of the endosome is required for transducing the signal. The exact mechanism is unknown except that v-ATPase is involved in the process. PMID:20699474 PMID:21380625 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8212.75" y="2266.5"/> <port id="pr_44a2dde0-7f2b-4e5c-b2d7-6e9fadc8f704_p1" x="8202.75" y="2271.5"/> <port id="pr_44a2dde0-7f2b-4e5c-b2d7-6e9fadc8f704_p2" x="8232.75" y="2271.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_8c9e2c54-1649-470a-93df-a0e900096336"> <bbox w="10.0" h="10.0" x="8304.25" y="2273.5"/> <port id="pr_8c9e2c54-1649-470a-93df-a0e900096336_p1" x="8309.25" y="2263.5"/> <port id="pr_8c9e2c54-1649-470a-93df-a0e900096336_p2" x="8309.25" y="2293.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1e764b71-7bab-4b14-97ef-dcf86e17415b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:11779461 PMID:18256687 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7497.838" y="2032.0"/> <port id="pr_1e764b71-7bab-4b14-97ef-dcf86e17415b_p1" x="7502.838" y="2052.0"/> <port id="pr_1e764b71-7bab-4b14-97ef-dcf86e17415b_p2" x="7502.838" y="2022.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_525c63b0-c10c-4d9d-a3bd-43466c76003c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Not sure if Rho dissociates when active References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7496.899" y="1726.5"/> <port id="pr_525c63b0-c10c-4d9d-a3bd-43466c76003c_p1" x="7501.899" y="1746.5"/> <port id="pr_525c63b0-c10c-4d9d-a3bd-43466c76003c_p2" x="7501.899" y="1716.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_9909c492-1076-4715-9790-87d66a38dd71"> <bbox w="10.0" h="10.0" x="7779.827" y="1482.875"/> <port id="pr_9909c492-1076-4715-9790-87d66a38dd71_p1" x="7784.827" y="1502.875"/> <port id="pr_9909c492-1076-4715-9790-87d66a38dd71_p2" x="7784.827" y="1472.875"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9743da82-d41e-44dd-bc70-ee09860a53db"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Binding of beta-arrestin to PTEN increases the lipid phosphatase activity of PTEN which converts PIP3 to PIP2. Active ROCK stimulates this complex formation PMID:21642958 ROCK phosphorylates PTEN which is than activated. Activated PTEN reduces the concentration of PIP3 PMID:15793569 PMID:20008297 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7762.0" y="1242.98"/> <port id="pr_9743da82-d41e-44dd-bc70-ee09860a53db_p1" x="7782.0" y="1247.98"/> <port id="pr_9743da82-d41e-44dd-bc70-ee09860a53db_p2" x="7752.0" y="1247.98"/> </glyph> <glyph class="process" orientation="vertical" id="pr_fb51c3e9-8223-4a32-a9f8-3a233f69eef9"> <bbox w="10.0" h="10.0" x="8247.867" y="1186.7075"/> <port id="pr_fb51c3e9-8223-4a32-a9f8-3a233f69eef9_p1" x="8252.867" y="1206.7075"/> <port id="pr_fb51c3e9-8223-4a32-a9f8-3a233f69eef9_p2" x="8252.867" y="1176.7075"/> </glyph> <glyph class="process" orientation="vertical" id="pr_bf09ce24-0555-4fa7-b301-50fbd711bd66"> <bbox w="10.0" h="10.0" x="8662.0" y="827.5"/> <port id="pr_bf09ce24-0555-4fa7-b301-50fbd711bd66_p1" x="8667.0" y="847.5"/> <port id="pr_bf09ce24-0555-4fa7-b301-50fbd711bd66_p2" x="8667.0" y="817.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_94010c88-deef-47a4-868c-016c7b7bb7cd"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Mechanism is unknown, it is speculate that translocalisation occurs through calpain-sensitive proteins. PMID:21266584 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8622.0" y="827.5"/> <port id="pr_94010c88-deef-47a4-868c-016c7b7bb7cd_p1" x="8627.0" y="817.5"/> <port id="pr_94010c88-deef-47a4-868c-016c7b7bb7cd_p2" x="8627.0" y="847.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c338ee46-52fe-4643-9dcb-03acc296750c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:21670566 PMID:17593948 There are more mechanisms to activate Calpain PMID:16129881 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8347.5" y="731.0"/> <port id="pr_c338ee46-52fe-4643-9dcb-03acc296750c_p1" x="8352.5" y="721.0"/> <port id="pr_c338ee46-52fe-4643-9dcb-03acc296750c_p2" x="8352.5" y="751.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_38b48307-2756-4de0-889d-231da019cf8c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19725819 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7618.034" y="713.0"/> <port id="pr_38b48307-2756-4de0-889d-231da019cf8c_p1" x="7623.034" y="733.0"/> <port id="pr_38b48307-2756-4de0-889d-231da019cf8c_p2" x="7623.034" y="703.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_eae1a0b9-01ae-45a0-8318-aafb9885b907"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PRR binds to subunits ATP6V0C/D of the ATPase to lower the pH in the endosome. The reason for this is unknown but it is speculated that a lower pH is required for remodeling of the actin skeleton. However, v-ATPase is necessary for signaling PMID:21796133 PMID:21380625 PMID:20093472 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7961.625" y="2196.0"/> <port id="pr_eae1a0b9-01ae-45a0-8318-aafb9885b907_p1" x="7951.625" y="2201.0"/> <port id="pr_eae1a0b9-01ae-45a0-8318-aafb9885b907_p2" x="7981.625" y="2201.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_978e4121-6123-4664-9dd5-ba60e414d056"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Wnt5 can binds to LRP5/6 and in this way, physiologically inhibits non-canonical pathway. In Xenopus and mice. PMID:19056682 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9943.5" y="433.0"/> <port id="pr_978e4121-6123-4664-9dd5-ba60e414d056_p1" x="9933.5" y="438.0"/> <port id="pr_978e4121-6123-4664-9dd5-ba60e414d056_p2" x="9963.5" y="438.0"/> </glyph> <glyph class="uncertain process" orientation="horizontal" id="pr_6c78efb0-729b-4b78-9816-c5e8a24a2f10"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Binding of Wnt5 and LRP5/6 leads to phosphorylation of Dvl. Most likely the same residues as picture shows same speed of migration on gel compared to Wnt3 stimulation. No phosphorylation of LRP5/6 by Wnt5. This complex formation sequesters away Wnt5 from the non-canonical pathway receptors PMID:19056682 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10101.4375" y="433.625"/> <port id="pr_6c78efb0-729b-4b78-9816-c5e8a24a2f10_p1" x="10091.4375" y="438.625"/> <port id="pr_6c78efb0-729b-4b78-9816-c5e8a24a2f10_p2" x="10121.4375" y="438.625"/> </glyph> <glyph class="process" orientation="vertical" id="pr_8e5f7182-3430-4b2e-8354-b6848ca3134c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:21506126, PMID:21303971 Path to phosphorylation of b-catenin is not completely depicted here. For full paths see AKT-pathway Activated CaSR inhibits phosphorylation of b-catenin, exact mechanism unknown PMID:22094462 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="11272.783" y="523.5"/> <port id="pr_8e5f7182-3430-4b2e-8354-b6848ca3134c_p1" x="11277.783" y="513.5"/> <port id="pr_8e5f7182-3430-4b2e-8354-b6848ca3134c_p2" x="11277.783" y="543.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_0f56bf94-b37f-45f8-a154-a943c5dcea5a"> <bbox w="10.0" h="10.0" x="11046.625" y="455.0"/> <port id="pr_0f56bf94-b37f-45f8-a154-a943c5dcea5a_p1" x="11036.625" y="460.0"/> <port id="pr_0f56bf94-b37f-45f8-a154-a943c5dcea5a_p2" x="11066.625" y="460.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5daaaf06-0060-444d-af53-f6a5b958af06"> <bbox w="10.0" h="10.0" x="11272.783" y="689.0"/> <port id="pr_5daaaf06-0060-444d-af53-f6a5b958af06_p1" x="11277.783" y="679.0"/> <port id="pr_5daaaf06-0060-444d-af53-f6a5b958af06_p2" x="11277.783" y="709.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_aabcc39b-d0bc-4832-906f-94aa7130af75"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17593948 PMID:18235236 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10462.0" y="669.65625"/> <port id="pr_aabcc39b-d0bc-4832-906f-94aa7130af75_p1" x="10467.0" y="659.65625"/> <port id="pr_aabcc39b-d0bc-4832-906f-94aa7130af75_p2" x="10467.0" y="689.65625"/> </glyph> <glyph class="process" orientation="vertical" id="pr_e6905997-bbf6-4ae2-a774-636b8d9a9d18"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Calcineurin can be proteolysed which results in a truncated form of the catalytic subunit A. The truncated form is constitutively active and irreversible and does not require calcium and calmodulin for activation. PMID:17593948, PMID:14627704 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10338.0" y="660.0"/> <port id="pr_e6905997-bbf6-4ae2-a774-636b8d9a9d18_p1" x="10343.0" y="650.0"/> <port id="pr_e6905997-bbf6-4ae2-a774-636b8d9a9d18_p2" x="10343.0" y="680.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_406dd083-e08a-4114-a789-caee926f1482"> <bbox w="10.0" h="10.0" x="10067.311" y="655.75"/> <port id="pr_406dd083-e08a-4114-a789-caee926f1482_p1" x="10072.311" y="645.75"/> <port id="pr_406dd083-e08a-4114-a789-caee926f1482_p2" x="10072.311" y="675.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_19ff749f-12dc-4b8a-8971-0658eb5e6832"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20514436 PMID:12114545 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9930.0" y="668.5"/> <port id="pr_19ff749f-12dc-4b8a-8971-0658eb5e6832_p1" x="9935.0" y="658.5"/> <port id="pr_19ff749f-12dc-4b8a-8971-0658eb5e6832_p2" x="9935.0" y="688.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_dd4ac5bc-58a6-4502-8411-c4cdd38d070b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:21738214, PMID:20709625 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10157.0" y="952.0"/> <port id="pr_dd4ac5bc-58a6-4502-8411-c4cdd38d070b_p1" x="10147.0" y="957.0"/> <port id="pr_dd4ac5bc-58a6-4502-8411-c4cdd38d070b_p2" x="10177.0" y="957.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_9ae8f5db-a0b2-4a6d-a607-80774b75c061"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20008353, PMID:20709625, PMID:21738214 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10265.36" y="1100.5"/> <port id="pr_9ae8f5db-a0b2-4a6d-a607-80774b75c061_p1" x="10270.36" y="1090.5"/> <port id="pr_9ae8f5db-a0b2-4a6d-a607-80774b75c061_p2" x="10270.36" y="1120.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a6a61149-39e4-48fd-8fa8-362c9553a1bf"> <bbox w="10.0" h="10.0" x="10196.0" y="1301.5"/> <port id="pr_a6a61149-39e4-48fd-8fa8-362c9553a1bf_p1" x="10216.0" y="1306.5"/> <port id="pr_a6a61149-39e4-48fd-8fa8-362c9553a1bf_p2" x="10186.0" y="1306.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ec6079d5-f280-4d87-a4b5-9cd6515c3fce"> <bbox w="10.0" h="10.0" x="10051.0" y="1350.5"/> <port id="pr_ec6079d5-f280-4d87-a4b5-9cd6515c3fce_p1" x="10071.0" y="1355.5"/> <port id="pr_ec6079d5-f280-4d87-a4b5-9cd6515c3fce_p2" x="10041.0" y="1355.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_0ac121f0-a34c-4c55-99f7-d31cc3236cb4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:21738214 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10051.0" y="1385.0"/> <port id="pr_0ac121f0-a34c-4c55-99f7-d31cc3236cb4_p1" x="10071.0" y="1390.0"/> <port id="pr_0ac121f0-a34c-4c55-99f7-d31cc3236cb4_p2" x="10041.0" y="1390.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_fc391cd6-2b42-4b14-aa76-f0632ee9f254"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20709625, PMID:14612448, PMID:21414921 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10080.5" y="1049.0"/> <port id="pr_fc391cd6-2b42-4b14-aa76-f0632ee9f254_p1" x="10100.5" y="1054.0"/> <port id="pr_fc391cd6-2b42-4b14-aa76-f0632ee9f254_p2" x="10070.5" y="1054.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_878c751a-98eb-4469-bd7c-31ad54527d46"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:21486225 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10145.0" y="1128.0"/> <port id="pr_878c751a-98eb-4469-bd7c-31ad54527d46_p1" x="10150.0" y="1118.0"/> <port id="pr_878c751a-98eb-4469-bd7c-31ad54527d46_p2" x="10150.0" y="1148.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6f88cc8f-72ff-49ce-b9da-cb912c2bb0fd"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:14681224, PMID:14612448 However, the mechanism in which truncated Bax increases apoptosis remains controversial. PMID:20008353 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10057.5" y="1206.0"/> <port id="pr_6f88cc8f-72ff-49ce-b9da-cb912c2bb0fd_p1" x="10077.5" y="1211.0"/> <port id="pr_6f88cc8f-72ff-49ce-b9da-cb912c2bb0fd_p2" x="10047.5" y="1211.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_98c90e95-9f70-4883-927c-4f974f6f75a3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Calpain might be involved in EMT as it can proteolyse many proteins that are involved in cell adhesion. PMID:16129881 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10201.801" y="683.0"/> <port id="pr_98c90e95-9f70-4883-927c-4f974f6f75a3_p1" x="10206.801" y="673.0"/> <port id="pr_98c90e95-9f70-4883-927c-4f974f6f75a3_p2" x="10206.801" y="703.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d523b005-6a3a-4852-908f-bc77d902cfc9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:10350048 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10715.25" y="659.0"/> <port id="pr_d523b005-6a3a-4852-908f-bc77d902cfc9_p1" x="10735.25" y="664.0"/> <port id="pr_d523b005-6a3a-4852-908f-bc77d902cfc9_p2" x="10705.25" y="664.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_23439b1a-766b-4f76-852f-bdf9c4c1387a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Formation is dependent of Ca2+ concentration. It is believed that Ca2+ concentration regulates activity of Calpastatin. PMID:12684003 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10639.795" y="734.0"/> <port id="pr_23439b1a-766b-4f76-852f-bdf9c4c1387a_p1" x="10644.795" y="724.0"/> <port id="pr_23439b1a-766b-4f76-852f-bdf9c4c1387a_p2" x="10644.795" y="754.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_0488411d-6a10-48f9-a485-7212e6e487a6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15036616, PMID:14741051 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10310.0" y="1613.0"/> <port id="pr_0488411d-6a10-48f9-a485-7212e6e487a6_p1" x="10330.0" y="1618.0"/> <port id="pr_0488411d-6a10-48f9-a485-7212e6e487a6_p2" x="10300.0" y="1618.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ca026cc0-847e-4603-b6ed-9fd78306e84a"> <bbox w="10.0" h="10.0" x="10397.455" y="1298.5"/> <port id="pr_ca026cc0-847e-4603-b6ed-9fd78306e84a_p1" x="10402.455" y="1318.5"/> <port id="pr_ca026cc0-847e-4603-b6ed-9fd78306e84a_p2" x="10402.455" y="1288.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_2cee8481-a9be-42a3-b30b-770742f36a6f"> <bbox w="10.0" h="10.0" x="10086.756" y="1407.5"/> <port id="pr_2cee8481-a9be-42a3-b30b-770742f36a6f_p1" x="10091.756" y="1427.5"/> <port id="pr_2cee8481-a9be-42a3-b30b-770742f36a6f_p2" x="10091.756" y="1397.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_8719ef05-f4c7-4091-975d-80fd5bc9014e"> <bbox w="10.0" h="10.0" x="10399.25" y="1499.5"/> <port id="pr_8719ef05-f4c7-4091-975d-80fd5bc9014e_p1" x="10404.25" y="1489.5"/> <port id="pr_8719ef05-f4c7-4091-975d-80fd5bc9014e_p2" x="10404.25" y="1519.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_bab6ac76-d214-4eba-84f7-0cd575df3f2f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:22088220 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10152.375" y="1613.0"/> <port id="pr_bab6ac76-d214-4eba-84f7-0cd575df3f2f_p1" x="10172.375" y="1618.0"/> <port id="pr_bab6ac76-d214-4eba-84f7-0cd575df3f2f_p2" x="10142.375" y="1618.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_45bce482-4902-4a13-90dd-2d9351862a47"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:22088220 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10057.75" y="1520.0"/> <port id="pr_45bce482-4902-4a13-90dd-2d9351862a47_p1" x="10062.75" y="1540.0"/> <port id="pr_45bce482-4902-4a13-90dd-2d9351862a47_p2" x="10062.75" y="1510.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_cb250aef-f35a-40b2-8186-1003ea413db7"> <bbox w="10.0" h="10.0" x="10500.0" y="1386.0"/> <port id="pr_cb250aef-f35a-40b2-8186-1003ea413db7_p1" x="10520.0" y="1391.0"/> <port id="pr_cb250aef-f35a-40b2-8186-1003ea413db7_p2" x="10490.0" y="1391.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c7039f4c-d559-426d-bfae-98dd166d10f7"> <bbox w="10.0" h="10.0" x="10593.0" y="1302.5"/> <port id="pr_c7039f4c-d559-426d-bfae-98dd166d10f7_p1" x="10598.0" y="1322.5"/> <port id="pr_c7039f4c-d559-426d-bfae-98dd166d10f7_p2" x="10598.0" y="1292.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_7c2fc10d-ae0b-45ac-96b0-2d86059143dc"> <bbox w="10.0" h="10.0" x="10593.0" y="1155.5"/> <port id="pr_7c2fc10d-ae0b-45ac-96b0-2d86059143dc_p1" x="10598.0" y="1175.5"/> <port id="pr_7c2fc10d-ae0b-45ac-96b0-2d86059143dc_p2" x="10598.0" y="1145.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_edf74730-364b-4dcf-bc89-489af4d4ab52"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17662023 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10703.25" y="1074.5"/> <port id="pr_edf74730-364b-4dcf-bc89-489af4d4ab52_p1" x="10693.25" y="1079.5"/> <port id="pr_edf74730-364b-4dcf-bc89-489af4d4ab52_p2" x="10723.25" y="1079.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_65b2408e-aecc-4b37-beb3-935e4a10bf54"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17662023 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10797.625" y="1448.25"/> <port id="pr_65b2408e-aecc-4b37-beb3-935e4a10bf54_p1" x="10802.625" y="1438.25"/> <port id="pr_65b2408e-aecc-4b37-beb3-935e4a10bf54_p2" x="10802.625" y="1468.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8fb59f4e-39c2-43b7-9309-2fda64fa8e5c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17662023 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10873.0" y="721.2597"/> <port id="pr_8fb59f4e-39c2-43b7-9309-2fda64fa8e5c_p1" x="10863.0" y="726.2597"/> <port id="pr_8fb59f4e-39c2-43b7-9309-2fda64fa8e5c_p2" x="10893.0" y="726.2597"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5abac755-a3d5-430b-b291-a9f57f4002ae"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17662023 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10999.75" y="865.0"/> <port id="pr_5abac755-a3d5-430b-b291-a9f57f4002ae_p1" x="11004.75" y="855.0"/> <port id="pr_5abac755-a3d5-430b-b291-a9f57f4002ae_p2" x="11004.75" y="885.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_9d8333d2-b3b1-4ed5-95a1-3854c64cfbc4"> <bbox w="10.0" h="10.0" x="10945.875" y="1628.0"/> <port id="pr_9d8333d2-b3b1-4ed5-95a1-3854c64cfbc4_p1" x="10950.875" y="1618.0"/> <port id="pr_9d8333d2-b3b1-4ed5-95a1-3854c64cfbc4_p2" x="10950.875" y="1648.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_1abf1b85-6c15-42a2-aa07-b0fe1ecfc0dc"> <bbox w="10.0" h="10.0" x="10952.25" y="704.7465"/> <port id="pr_1abf1b85-6c15-42a2-aa07-b0fe1ecfc0dc_p1" x="10942.25" y="709.7465"/> <port id="pr_1abf1b85-6c15-42a2-aa07-b0fe1ecfc0dc_p2" x="10972.25" y="709.7465"/> </glyph> <glyph class="process" orientation="vertical" id="pr_865f4271-2a00-4437-a861-6782a11b3fbe"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:21115349 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="11147.5" y="878.0"/> <port id="pr_865f4271-2a00-4437-a861-6782a11b3fbe_p1" x="11152.5" y="868.0"/> <port id="pr_865f4271-2a00-4437-a861-6782a11b3fbe_p2" x="11152.5" y="898.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_762dc50e-0cfe-4f04-bb52-681512ff6499"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19136967 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="11146.875" y="1660.75"/> <port id="pr_762dc50e-0cfe-4f04-bb52-681512ff6499_p1" x="11151.875" y="1650.75"/> <port id="pr_762dc50e-0cfe-4f04-bb52-681512ff6499_p2" x="11151.875" y="1680.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1156657d-639b-4bb3-9906-66b8ffa995be"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Tubulin-alpha binds both NFAT and KPNB1 after dephosphorylation of NFAT. PMID:21278340 TNPO1 is a transport protein that helps in the import of proteins into the nucleus. Although it has been described with associated with NRON, it is most likely that it binds first to NFAT complex, making this complex ready for import, then NRON can bind to this complex to hinder the import of the complex PMID:21709260 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="11146.742" y="1265.5"/> <port id="pr_1156657d-639b-4bb3-9906-66b8ffa995be_p1" x="11151.742" y="1255.5"/> <port id="pr_1156657d-639b-4bb3-9906-66b8ffa995be_p2" x="11151.742" y="1285.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_8f17f8ed-19d0-4123-8c9c-d1433a9b9283"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Tubulin-alpha binds both NFAT and KPNB1 after dephosphorylation of NFAT. PMID:21278340 TNPO1 is a transport protein that helps in the import of proteins into the nucleus. Although it has been described with associated with NRON, it is most likely that it binds first to NFAT complex, making this complex ready for import, then NRON can bind to this complex to hinder the import of the complex PMID:21709260 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10947.8125" y="1267.25"/> <port id="pr_8f17f8ed-19d0-4123-8c9c-d1433a9b9283_p1" x="10952.8125" y="1257.25"/> <port id="pr_8f17f8ed-19d0-4123-8c9c-d1433a9b9283_p2" x="10952.8125" y="1287.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f4dc6ed9-35c1-4f47-8b11-e4fabb2b73cf"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Upon Ca2+ activation the NRON-NFAT complex dissociates. PMID:21709260 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="11518.125" y="689.7859"/> <port id="pr_f4dc6ed9-35c1-4f47-8b11-e4fabb2b73cf_p1" x="11538.125" y="694.7859"/> <port id="pr_f4dc6ed9-35c1-4f47-8b11-e4fabb2b73cf_p2" x="11508.125" y="694.7859"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6c39ed46-363d-4219-be53-b685959b4f66"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: LRKK2 mediates binding of NFAT to NRON and other components, but this is independent of its kinase activity and independent of the phosphorylation status of NFAT PMID:21983832 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="11532.25" y="1065.3895"/> <port id="pr_6c39ed46-363d-4219-be53-b685959b4f66_p1" x="11522.25" y="1070.3895"/> <port id="pr_6c39ed46-363d-4219-be53-b685959b4f66_p2" x="11552.25" y="1070.3895"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_383e13cc-e781-4252-925b-9914ca5a7b9b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:21709260 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="11494.4375" y="1398.5"/> <port id="pr_383e13cc-e781-4252-925b-9914ca5a7b9b_p1" x="11484.4375" y="1403.5"/> <port id="pr_383e13cc-e781-4252-925b-9914ca5a7b9b_p2" x="11514.4375" y="1403.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_70819c4b-db5a-4399-9e05-2edbe28ea597"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:2550447, PMID:19608982 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10462.25" y="946.5"/> <port id="pr_70819c4b-db5a-4399-9e05-2edbe28ea597_p1" x="10467.25" y="936.5"/> <port id="pr_70819c4b-db5a-4399-9e05-2edbe28ea597_p2" x="10467.25" y="966.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_92bd776a-d263-4608-a0ff-4d48991cf718"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:16131541 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10757.25" y="549.5"/> <port id="pr_92bd776a-d263-4608-a0ff-4d48991cf718_p1" x="10747.25" y="554.5"/> <port id="pr_92bd776a-d263-4608-a0ff-4d48991cf718_p2" x="10777.25" y="554.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_166d688f-e7bd-4476-9cc2-463395c0efb0"> <bbox w="10.0" h="10.0" x="11798.389" y="839.25"/> <port id="pr_166d688f-e7bd-4476-9cc2-463395c0efb0_p1" x="11818.389" y="844.25"/> <port id="pr_166d688f-e7bd-4476-9cc2-463395c0efb0_p2" x="11788.389" y="844.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_01c69968-4537-4eca-af60-fb9fafb6a68a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19136967 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="11565.549" y="1006.75"/> <port id="pr_01c69968-4537-4eca-af60-fb9fafb6a68a_p1" x="11570.549" y="996.75"/> <port id="pr_01c69968-4537-4eca-af60-fb9fafb6a68a_p2" x="11570.549" y="1026.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f9cb0cfe-dd7b-4692-b5c2-2e499c0417c9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19136967 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="11446.4375" y="893.75"/> <port id="pr_f9cb0cfe-dd7b-4692-b5c2-2e499c0417c9_p1" x="11466.4375" y="898.75"/> <port id="pr_f9cb0cfe-dd7b-4692-b5c2-2e499c0417c9_p2" x="11436.4375" y="898.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9c41e23c-0453-47e9-8b01-5bd54b0c0cca"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:18218901 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9985.25" y="1766.0"/> <port id="pr_9c41e23c-0453-47e9-8b01-5bd54b0c0cca_p1" x="10005.25" y="1771.0"/> <port id="pr_9c41e23c-0453-47e9-8b01-5bd54b0c0cca_p2" x="9975.25" y="1771.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c1f8116d-e294-4392-bf06-4b3d02268d81"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Homer1 binds only NFATc4/NFAT3, whereas NFATc3/NFAT4 does not bind to any Homer protein. PMID:18218901 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10199.726" y="1783.5"/> <port id="pr_c1f8116d-e294-4392-bf06-4b3d02268d81_p1" x="10204.726" y="1773.5"/> <port id="pr_c1f8116d-e294-4392-bf06-4b3d02268d81_p2" x="10204.726" y="1803.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c6946c48-62c5-4e84-99a0-97377bf8ecb2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: DYRK1A/B primes NFAT in the nucleus, DYRK2 in the cytosol PMID:16511445 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="11203.25" y="2083.0"/> <port id="pr_c6946c48-62c5-4e84-99a0-97377bf8ecb2_p1" x="11193.25" y="2088.0"/> <port id="pr_c6946c48-62c5-4e84-99a0-97377bf8ecb2_p2" x="11223.25" y="2088.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f49c13d5-b26c-44b7-822f-46b0d8bde359"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:16511445, PMID:15121840 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="11384.0" y="2083.0"/> <port id="pr_f49c13d5-b26c-44b7-822f-46b0d8bde359_p1" x="11374.0" y="2088.0"/> <port id="pr_f49c13d5-b26c-44b7-822f-46b0d8bde359_p2" x="11404.0" y="2088.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1d972708-4b4b-49a0-b8a5-dcce4b19bbf7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:10788511, PMID:10094050, PMID:9585406 For a more detailed mechanism see CRM1 in map Nucleus_MTOR References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="11497.0" y="1833.5"/> <port id="pr_1d972708-4b4b-49a0-b8a5-dcce4b19bbf7_p1" x="11502.0" y="1853.5"/> <port id="pr_1d972708-4b4b-49a0-b8a5-dcce4b19bbf7_p2" x="11502.0" y="1823.5"/> </glyph> <glyph class="uncertain process" orientation="vertical" id="pr_58e1f1f7-ee4f-4b4d-b687-120ef47ede2d"> <bbox w="10.0" h="10.0" x="11563.25" y="1116.0"/> <port id="pr_58e1f1f7-ee4f-4b4d-b687-120ef47ede2d_p1" x="11568.25" y="1136.0"/> <port id="pr_58e1f1f7-ee4f-4b4d-b687-120ef47ede2d_p2" x="11568.25" y="1106.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c6c11c15-c70e-4258-807f-b9e1b0302df4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: DYRK1A-mediated phosphorylation PMID:21965663 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10627.0" y="1028.5"/> <port id="pr_c6c11c15-c70e-4258-807f-b9e1b0302df4_p1" x="10632.0" y="1048.5"/> <port id="pr_c6c11c15-c70e-4258-807f-b9e1b0302df4_p2" x="10632.0" y="1018.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_9efef8bc-8af7-4884-bc0a-80b3f4c092e7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:21965663, PMID:12063245 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10564.0" y="1631.0"/> <port id="pr_9efef8bc-8af7-4884-bc0a-80b3f4c092e7_p1" x="10569.0" y="1621.0"/> <port id="pr_9efef8bc-8af7-4884-bc0a-80b3f4c092e7_p2" x="10569.0" y="1651.0"/> </glyph> <glyph class="or" orientation="horizontal" id="logicglyph_64fb4fd2-7ea7-45b7-81cc-7b9479533ead"> <bbox w="20.0" h="20.0" x="10928.666" y="1334.3334"/> <port id="logicglyph_64fb4fd2-7ea7-45b7-81cc-7b9479533ead_p1" x="10958.666" y="1344.3334"/> <port id="logicglyph_64fb4fd2-7ea7-45b7-81cc-7b9479533ead_p2" x="10918.666" y="1344.3334"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ddcc210f-fb33-4314-8f7e-eca7a4283a4a"> <bbox w="10.0" h="10.0" x="10564.0" y="1739.5"/> <port id="pr_ddcc210f-fb33-4314-8f7e-eca7a4283a4a_p1" x="10569.0" y="1729.5"/> <port id="pr_ddcc210f-fb33-4314-8f7e-eca7a4283a4a_p2" x="10569.0" y="1759.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_3708a75d-c5fc-4c10-9ce5-d3e88c1423ec"> <bbox w="10.0" h="10.0" x="10718.5" y="1508.0"/> <port id="pr_3708a75d-c5fc-4c10-9ce5-d3e88c1423ec_p1" x="10723.5" y="1498.0"/> <port id="pr_3708a75d-c5fc-4c10-9ce5-d3e88c1423ec_p2" x="10723.5" y="1528.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_bfe04d09-db0e-4aa1-b97b-df5609318b37"> <bbox w="10.0" h="10.0" x="11139.088" y="2015.5"/> <port id="pr_bfe04d09-db0e-4aa1-b97b-df5609318b37_p1" x="11144.088" y="2005.5"/> <port id="pr_bfe04d09-db0e-4aa1-b97b-df5609318b37_p2" x="11144.088" y="2035.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8291c9af-4ba0-412d-afc8-a08ca4363bcf"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:11796223 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10500.75" y="1963.0"/> <port id="pr_8291c9af-4ba0-412d-afc8-a08ca4363bcf_p1" x="10490.75" y="1968.0"/> <port id="pr_8291c9af-4ba0-412d-afc8-a08ca4363bcf_p2" x="10520.75" y="1968.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_56c2974b-7a66-47f8-b9f8-077bcc1244a7"> <bbox w="10.0" h="10.0" x="10685.5" y="1963.0"/> <port id="pr_56c2974b-7a66-47f8-b9f8-077bcc1244a7_p1" x="10675.5" y="1968.0"/> <port id="pr_56c2974b-7a66-47f8-b9f8-077bcc1244a7_p2" x="10705.5" y="1968.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_f31eee29-4467-4a0a-9672-bdea45ad33d1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15489953 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10284.75" y="1301.5"/> <port id="pr_f31eee29-4467-4a0a-9672-bdea45ad33d1_p1" x="10289.75" y="1291.5"/> <port id="pr_f31eee29-4467-4a0a-9672-bdea45ad33d1_p2" x="10289.75" y="1321.5"/> </glyph> <glyph class="and" orientation="vertical" id="logicglyph_1579d8a2-095e-4d09-8f9a-9eeefec54991"> <bbox w="20.0" h="20.0" x="10089.0" y="1954.0"/> <port id="logicglyph_1579d8a2-095e-4d09-8f9a-9eeefec54991_p1" x="10099.0" y="1984.0"/> <port id="logicglyph_1579d8a2-095e-4d09-8f9a-9eeefec54991_p2" x="10099.0" y="1944.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_e0ee62f2-3218-4d2a-8353-7ba4fb104c72"> <bbox w="10.0" h="10.0" x="10271.75" y="2053.0"/> <port id="pr_e0ee62f2-3218-4d2a-8353-7ba4fb104c72_p1" x="10261.75" y="2058.0"/> <port id="pr_e0ee62f2-3218-4d2a-8353-7ba4fb104c72_p2" x="10291.75" y="2058.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a980bfc9-53bd-44d4-82b7-e46c3e51053b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Only NFAT1 is sensitive to cleavage by caspase-3 at consensus sites: DELD and/or DVLD. PMID:16455648 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10754.5" y="1041.0"/> <port id="pr_a980bfc9-53bd-44d4-82b7-e46c3e51053b_p1" x="10759.5" y="1031.0"/> <port id="pr_a980bfc9-53bd-44d4-82b7-e46c3e51053b_p2" x="10759.5" y="1061.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_fc2d995c-8f32-4092-b504-c052a8da4131"> <bbox w="10.0" h="10.0" x="10364.25" y="2054.7515"/> <port id="pr_fc2d995c-8f32-4092-b504-c052a8da4131_p1" x="10384.25" y="2059.7515"/> <port id="pr_fc2d995c-8f32-4092-b504-c052a8da4131_p2" x="10354.25" y="2059.7515"/> </glyph> <glyph class="process" orientation="vertical" id="pr_8fbea444-f1ba-4783-890b-e27f8120fa5a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Where exactly MDM2 ubiquitinates NFAT is not known and also not known if it is in the cytosol or nucleus. PMID:16307918 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10629.25" y="1426.0"/> <port id="pr_8fbea444-f1ba-4783-890b-e27f8120fa5a_p1" x="10634.25" y="1416.0"/> <port id="pr_8fbea444-f1ba-4783-890b-e27f8120fa5a_p2" x="10634.25" y="1446.0"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_2cc685f1-511d-452d-a757-bc8224a7e671"> <bbox w="20.0" h="20.0" x="10231.75" y="1786.5"/> <port id="logicglyph_2cc685f1-511d-452d-a757-bc8224a7e671_p1" x="10221.75" y="1796.5"/> <port id="logicglyph_2cc685f1-511d-452d-a757-bc8224a7e671_p2" x="10261.75" y="1796.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_8b054de9-b847-4636-a2f9-35ae05ad715f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18762249 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9826.0" y="2213.0"/> <port id="pr_8b054de9-b847-4636-a2f9-35ae05ad715f_p1" x="9831.0" y="2203.0"/> <port id="pr_8b054de9-b847-4636-a2f9-35ae05ad715f_p2" x="9831.0" y="2233.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_3e47296b-f0df-4975-9f7c-2e39589bfe60"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18762249 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9838.922" y="2445.75"/> <port id="pr_3e47296b-f0df-4975-9f7c-2e39589bfe60_p1" x="9843.922" y="2435.75"/> <port id="pr_3e47296b-f0df-4975-9f7c-2e39589bfe60_p2" x="9843.922" y="2465.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ba10ee94-176c-453a-9d7a-78cbb86a3dfa"> <bbox w="10.0" h="10.0" x="9798.25" y="2032.0757"/> <port id="pr_ba10ee94-176c-453a-9d7a-78cbb86a3dfa_p1" x="9788.25" y="2037.0757"/> <port id="pr_ba10ee94-176c-453a-9d7a-78cbb86a3dfa_p2" x="9818.25" y="2037.0757"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b2f92522-dc9e-4a21-b68b-84758db0263a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:16648474 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9925.0" y="1053.0"/> <port id="pr_b2f92522-dc9e-4a21-b68b-84758db0263a_p1" x="9930.0" y="1073.0"/> <port id="pr_b2f92522-dc9e-4a21-b68b-84758db0263a_p2" x="9930.0" y="1043.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_df20e3ca-ea79-4fd8-8fc4-682c5c2bd1f8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Most likely, the complex will dissociates PMID:16648474 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10948.25" y="865.0"/> <port id="pr_df20e3ca-ea79-4fd8-8fc4-682c5c2bd1f8_p1" x="10953.25" y="885.0"/> <port id="pr_df20e3ca-ea79-4fd8-8fc4-682c5c2bd1f8_p2" x="10953.25" y="855.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c26fadb0-f859-402f-ae69-ff1110cfe1b7"> <bbox w="10.0" h="10.0" x="10366.046" y="1175.0"/> <port id="pr_c26fadb0-f859-402f-ae69-ff1110cfe1b7_p1" x="10356.046" y="1180.0"/> <port id="pr_c26fadb0-f859-402f-ae69-ff1110cfe1b7_p2" x="10386.046" y="1180.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a6fe4db4-fc95-42fe-9dc0-de528724d2f6"> <bbox w="10.0" h="10.0" x="10306.32" y="1185.0"/> <port id="pr_a6fe4db4-fc95-42fe-9dc0-de528724d2f6_p1" x="10296.32" y="1190.0"/> <port id="pr_a6fe4db4-fc95-42fe-9dc0-de528724d2f6_p2" x="10326.32" y="1190.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_40b9a772-95ec-496b-9a70-a035d98d5b6b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: S272 and S89 are PKA sites in NFAT3 PMID:10611249 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="11046.0" y="2083.0"/> <port id="pr_40b9a772-95ec-496b-9a70-a035d98d5b6b_p1" x="11066.0" y="2088.0"/> <port id="pr_40b9a772-95ec-496b-9a70-a035d98d5b6b_p2" x="11036.0" y="2088.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_55e66882-a975-40d8-b493-879f06dad557"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:10611249 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10883.25" y="2123.5"/> <port id="pr_55e66882-a975-40d8-b493-879f06dad557_p1" x="10903.25" y="2128.5"/> <port id="pr_55e66882-a975-40d8-b493-879f06dad557_p2" x="10873.25" y="2128.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_4e08bd19-b83f-4da6-87c2-b9e4a6524bc2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:10611249 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10702.5" y="2123.75"/> <port id="pr_4e08bd19-b83f-4da6-87c2-b9e4a6524bc2_p1" x="10722.5" y="2128.75"/> <port id="pr_4e08bd19-b83f-4da6-87c2-b9e4a6524bc2_p2" x="10692.5" y="2128.75"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_f447db86-d8cf-4163-9656-a954cfed100c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: TGF-beta upregelates gene expression of NFAT1 and NFAT2 via Ca2+/Calcineurin pathway PMID:20516082 P38 MAPK activates NFATc/NFAT2 promoter PMID:12944472 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7782.5" y="3241.3984"/> <port id="pr_f447db86-d8cf-4163-9656-a954cfed100c_p1" x="7772.5" y="3246.3984"/> <port id="pr_f447db86-d8cf-4163-9656-a954cfed100c_p2" x="7802.5" y="3246.3984"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_5978e9d2-4a15-4c1f-8bd9-b41b6c968734"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:20516082 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7886.5" y="3319.0"/> <port id="pr_5978e9d2-4a15-4c1f-8bd9-b41b6c968734_p1" x="7876.5" y="3324.0"/> <port id="pr_5978e9d2-4a15-4c1f-8bd9-b41b6c968734_p2" x="7906.5" y="3324.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_312f8c4a-5773-4e88-be7b-230d9e0637b4"> <bbox w="10.0" h="10.0" x="7788.0" y="3098.0"/> <port id="pr_312f8c4a-5773-4e88-be7b-230d9e0637b4_p1" x="7793.0" y="3088.0"/> <port id="pr_312f8c4a-5773-4e88-be7b-230d9e0637b4_p2" x="7793.0" y="3118.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_cda90329-e770-4849-87bc-fb85f9ad9543"> <bbox w="10.0" h="10.0" x="7871.868" y="3098.5"/> <port id="pr_cda90329-e770-4849-87bc-fb85f9ad9543_p1" x="7876.868" y="3088.5"/> <port id="pr_cda90329-e770-4849-87bc-fb85f9ad9543_p2" x="7876.868" y="3118.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_0e55e112-191f-49ab-b1a4-54c5448aa8be"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15657420 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7751.5" y="3518.3513"/> <port id="pr_0e55e112-191f-49ab-b1a4-54c5448aa8be_p1" x="7741.5" y="3523.3513"/> <port id="pr_0e55e112-191f-49ab-b1a4-54c5448aa8be_p2" x="7771.5" y="3523.3513"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d29bd802-805a-4972-8c48-086083611b6f"> <bbox w="10.0" h="10.0" x="7802.875" y="3663.0"/> <port id="pr_d29bd802-805a-4972-8c48-086083611b6f_p1" x="7792.875" y="3668.0"/> <port id="pr_d29bd802-805a-4972-8c48-086083611b6f_p2" x="7822.875" y="3668.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_02e334e5-d056-4d5c-9c33-bb3adc579762"> <bbox w="10.0" h="10.0" x="7783.0" y="3776.5713"/> <port id="pr_02e334e5-d056-4d5c-9c33-bb3adc579762_p1" x="7773.0" y="3781.5713"/> <port id="pr_02e334e5-d056-4d5c-9c33-bb3adc579762_p2" x="7803.0" y="3781.5713"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_73601109-7ca4-4c87-abb2-5bb73252d828"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:11796223 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7779.5" y="3902.4517"/> <port id="pr_73601109-7ca4-4c87-abb2-5bb73252d828_p1" x="7769.5" y="3907.4517"/> <port id="pr_73601109-7ca4-4c87-abb2-5bb73252d828_p2" x="7799.5" y="3907.4517"/> </glyph> <glyph class="process" orientation="vertical" id="pr_602b5ef0-ce57-492a-8893-408371c88c9d"> <bbox w="10.0" h="10.0" x="8300.0" y="3019.75"/> <port id="pr_602b5ef0-ce57-492a-8893-408371c88c9d_p1" x="8305.0" y="3009.75"/> <port id="pr_602b5ef0-ce57-492a-8893-408371c88c9d_p2" x="8305.0" y="3039.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_60a02bff-2cc6-4252-beda-10b68281b5dd"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:22275375, PMID:15657064, PMID:16396959, PMID:16998587 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8197.141" y="3316.5"/> <port id="pr_60a02bff-2cc6-4252-beda-10b68281b5dd_p1" x="8202.141" y="3306.5"/> <port id="pr_60a02bff-2cc6-4252-beda-10b68281b5dd_p2" x="8202.141" y="3336.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_703e6834-325f-4464-848f-f2f8e87c8e0f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15657420 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8368.25" y="3467.0"/> <port id="pr_703e6834-325f-4464-848f-f2f8e87c8e0f_p1" x="8388.25" y="3472.0"/> <port id="pr_703e6834-325f-4464-848f-f2f8e87c8e0f_p2" x="8358.25" y="3472.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d324f7b0-0be0-4283-8112-ecdba422c54b"> <bbox w="10.0" h="10.0" x="8145.5" y="3200.5"/> <port id="pr_d324f7b0-0be0-4283-8112-ecdba422c54b_p1" x="8135.5" y="3205.5"/> <port id="pr_d324f7b0-0be0-4283-8112-ecdba422c54b_p2" x="8165.5" y="3205.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_36f22322-c241-4755-8f2c-73630cf0dd47"> <bbox w="10.0" h="10.0" x="7763.25" y="3288.75"/> <port id="pr_36f22322-c241-4755-8f2c-73630cf0dd47_p1" x="7768.25" y="3278.75"/> <port id="pr_36f22322-c241-4755-8f2c-73630cf0dd47_p2" x="7768.25" y="3308.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_429e9282-3bed-4844-a7a3-8126727994fe"> <bbox w="10.0" h="10.0" x="7806.75" y="3288.75"/> <port id="pr_429e9282-3bed-4844-a7a3-8126727994fe_p1" x="7811.75" y="3278.75"/> <port id="pr_429e9282-3bed-4844-a7a3-8126727994fe_p2" x="7811.75" y="3308.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_01491629-6461-4c6b-9f8c-3793480ca53c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:21376121 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7754.75" y="3381.5"/> <port id="pr_01491629-6461-4c6b-9f8c-3793480ca53c_p1" x="7759.75" y="3371.5"/> <port id="pr_01491629-6461-4c6b-9f8c-3793480ca53c_p2" x="7759.75" y="3401.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_7132383d-e6a5-417b-8b4d-c1bc98fed2a7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Sequential sumoylion of NFAT1, might also occur in NFAT3 and 4. There is no special character for sumoylation in CellDesigner, so this is indicated by a "?". Lys684 is targeted firstly, followed by Lys897. PMID:15117942 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8600.0" y="3242.5"/> <port id="pr_7132383d-e6a5-417b-8b4d-c1bc98fed2a7_p1" x="8605.0" y="3232.5"/> <port id="pr_7132383d-e6a5-417b-8b4d-c1bc98fed2a7_p2" x="8605.0" y="3262.5"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_7e446db4-65de-4f8c-80da-b637e3b5ef57"> <bbox w="20.0" h="20.0" x="8705.75" y="3274.75"/> <port id="logicglyph_7e446db4-65de-4f8c-80da-b637e3b5ef57_p1" x="8735.75" y="3284.75"/> <port id="logicglyph_7e446db4-65de-4f8c-80da-b637e3b5ef57_p2" x="8695.75" y="3284.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_8eeb0360-9a17-4127-b91f-de9932e56f57"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Sequential sumoylion of NFAT1, might also occur in NFAT3 and 4. There is no special character for sumoylation in CellDesigner, so this is indicated by a "?". Lys684 is targeted firstly, followed by Lys897. PMID:15117942 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8600.0" y="3341.0"/> <port id="pr_8eeb0360-9a17-4127-b91f-de9932e56f57_p1" x="8605.0" y="3331.0"/> <port id="pr_8eeb0360-9a17-4127-b91f-de9932e56f57_p2" x="8605.0" y="3361.0"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_3d6fde74-f4f1-49fa-9e3a-64c96aeba2e2"> <bbox w="20.0" h="20.0" x="8707.0" y="3300.0"/> <port id="logicglyph_3d6fde74-f4f1-49fa-9e3a-64c96aeba2e2_p1" x="8737.0" y="3310.0"/> <port id="logicglyph_3d6fde74-f4f1-49fa-9e3a-64c96aeba2e2_p2" x="8697.0" y="3310.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1ad15184-2144-4e43-bc49-38d02034c655"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Order of sumoylation is not important. PMID:19218564 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8969.5" y="3242.5"/> <port id="pr_1ad15184-2144-4e43-bc49-38d02034c655_p1" x="8974.5" y="3232.5"/> <port id="pr_1ad15184-2144-4e43-bc49-38d02034c655_p2" x="8974.5" y="3262.5"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_708489ac-2f51-44b7-b610-84fe512ed114"> <bbox w="20.0" h="20.0" x="8852.5" y="3273.5"/> <port id="logicglyph_708489ac-2f51-44b7-b610-84fe512ed114_p1" x="8842.5" y="3283.5"/> <port id="logicglyph_708489ac-2f51-44b7-b610-84fe512ed114_p2" x="8882.5" y="3283.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_855643d9-5a01-4452-ad5e-c4be2e5ac1be"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19218564, PMID:17928811 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9192.261" y="3440.25"/> <port id="pr_855643d9-5a01-4452-ad5e-c4be2e5ac1be_p1" x="9197.261" y="3430.25"/> <port id="pr_855643d9-5a01-4452-ad5e-c4be2e5ac1be_p2" x="9197.261" y="3460.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_4db67226-4636-4e45-b365-d268357c7bff"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19218564 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8182.5" y="3576.0"/> <port id="pr_4db67226-4636-4e45-b365-d268357c7bff_p1" x="8172.5" y="3581.0"/> <port id="pr_4db67226-4636-4e45-b365-d268357c7bff_p2" x="8202.5" y="3581.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_e10f09c2-92cc-46a4-a487-2c24d2269159"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: This arrow is to indicate that phosphorylated NFAT3 is also involved in complex formation of NFAT/AP-1 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="7975.5" y="3534.25"/> <port id="pr_e10f09c2-92cc-46a4-a487-2c24d2269159_p1" x="7995.5" y="3539.25"/> <port id="pr_e10f09c2-92cc-46a4-a487-2c24d2269159_p2" x="7965.5" y="3539.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_e2aa6502-ac13-42cd-a66a-7dd496672c84"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: To indicate that sumoylated NFAT1 forms as well NFAT/AP comlexes. References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8147.5" y="3506.25"/> <port id="pr_e2aa6502-ac13-42cd-a66a-7dd496672c84_p1" x="8167.5" y="3511.25"/> <port id="pr_e2aa6502-ac13-42cd-a66a-7dd496672c84_p2" x="8137.5" y="3511.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1114265a-e92f-4288-9eaf-44562657d5f2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFATs are ADP-ribosylated. Also NFAT2 @E427, NFAT3 @E418, NFAT4@E432 There is not special character to indicated this PTM, I have used glycosylation instead. PMID:18299389, PMID:18078995 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8687.75" y="3333.0"/> <port id="pr_1114265a-e92f-4288-9eaf-44562657d5f2_p1" x="8692.75" y="3323.0"/> <port id="pr_1114265a-e92f-4288-9eaf-44562657d5f2_p2" x="8692.75" y="3353.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2b1531d3-b0f6-4c93-a453-f84dba4560e6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: This isoform of NFAT1 forms also NFAT/AP-1 complexes. References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8215.25" y="3536.75"/> <port id="pr_2b1531d3-b0f6-4c93-a453-f84dba4560e6_p1" x="8235.25" y="3541.75"/> <port id="pr_2b1531d3-b0f6-4c93-a453-f84dba4560e6_p2" x="8205.25" y="3541.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d476b01d-f760-4b65-8eec-9f35c3d0094e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12453415 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8177.0" y="3624.0"/> <port id="pr_d476b01d-f760-4b65-8eec-9f35c3d0094e_p1" x="8167.0" y="3629.0"/> <port id="pr_d476b01d-f760-4b65-8eec-9f35c3d0094e_p2" x="8197.0" y="3629.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_d869e93f-dce4-4a6c-88e3-e96267f0bb34"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:12453415 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8970.119" y="3485.5"/> <port id="pr_d869e93f-dce4-4a6c-88e3-e96267f0bb34_p1" x="8975.119" y="3475.5"/> <port id="pr_d869e93f-dce4-4a6c-88e3-e96267f0bb34_p2" x="8975.119" y="3505.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f83b20be-aaaa-4ac3-a8b6-236b28d8b66d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: NFAT1 together with JUN/FOS=AP-1 activates the promoter of GPC6 PMID:21871017 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8177.0" y="3660.0"/> <port id="pr_f83b20be-aaaa-4ac3-a8b6-236b28d8b66d_p1" x="8167.0" y="3665.0"/> <port id="pr_f83b20be-aaaa-4ac3-a8b6-236b28d8b66d_p2" x="8197.0" y="3665.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_d0c404b0-1464-44f4-925f-61111d090230"> <bbox w="10.0" h="10.0" x="8128.577" y="3874.0"/> <port id="pr_d0c404b0-1464-44f4-925f-61111d090230_p1" x="8133.577" y="3864.0"/> <port id="pr_d0c404b0-1464-44f4-925f-61111d090230_p2" x="8133.577" y="3894.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_23a3e8c5-6b1a-45fb-9348-6c335b9eb8c4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID15657416 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8276.5" y="3778.7722"/> <port id="pr_23a3e8c5-6b1a-45fb-9348-6c335b9eb8c4_p1" x="8266.5" y="3783.7722"/> <port id="pr_23a3e8c5-6b1a-45fb-9348-6c335b9eb8c4_p2" x="8296.5" y="3783.7722"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_bcf0a047-7127-43e7-a27f-b5917163cbee"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: CnA binds to MEK1, MEK1 binds to ERK2 and ERK2 phosphorylates NFAT PMID15657416 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8525.0" y="3779.0"/> <port id="pr_bcf0a047-7127-43e7-a27f-b5917163cbee_p1" x="8515.0" y="3784.0"/> <port id="pr_bcf0a047-7127-43e7-a27f-b5917163cbee_p2" x="8545.0" y="3784.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_3c696801-c935-4a67-856d-208091d9afb2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Phosphorylation of NFAT leads to increased DNA binding of NFAT -> increased gene transcription PMID15657416 Not sure if dissociation of calcineurin and ERK/MEK occurs References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="8661.25" y="3677.0"/> <port id="pr_3c696801-c935-4a67-856d-208091d9afb2_p1" x="8666.25" y="3697.0"/> <port id="pr_3c696801-c935-4a67-856d-208091d9afb2_p2" x="8666.25" y="3667.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_285a3894-614d-42d0-aab0-d0fdf09e611f"> <bbox w="10.0" h="10.0" x="8058.178" y="3477.5"/> <port id="pr_285a3894-614d-42d0-aab0-d0fdf09e611f_p1" x="8063.178" y="3467.5"/> <port id="pr_285a3894-614d-42d0-aab0-d0fdf09e611f_p2" x="8063.178" y="3497.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_cb31c810-775c-4f3d-9534-2cfb852f593d"> <bbox w="10.0" h="10.0" x="8104.1064" y="3477.5"/> <port id="pr_cb31c810-775c-4f3d-9534-2cfb852f593d_p1" x="8109.1064" y="3467.5"/> <port id="pr_cb31c810-775c-4f3d-9534-2cfb852f593d_p2" x="8109.1064" y="3497.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d6b3244d-5126-4edf-9b3b-6fa3d18b2fa5"> <bbox w="10.0" h="10.0" x="10317.0" y="3000.0"/> <port id="pr_d6b3244d-5126-4edf-9b3b-6fa3d18b2fa5_p1" x="10307.0" y="3005.0"/> <port id="pr_d6b3244d-5126-4edf-9b3b-6fa3d18b2fa5_p2" x="10337.0" y="3005.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d76b06bb-2184-485d-ba74-24931ba06f1e"> <bbox w="10.0" h="10.0" x="9952.5" y="2998.0"/> <port id="pr_d76b06bb-2184-485d-ba74-24931ba06f1e_p1" x="9942.5" y="3003.0"/> <port id="pr_d76b06bb-2184-485d-ba74-24931ba06f1e_p2" x="9972.5" y="3003.0"/> </glyph> <glyph class="omitted process" orientation="vertical" id="pr_8728fa11-4ed3-4232-8dbd-91d4023cfcd5"> <bbox w="10.0" h="10.0" x="10110.961" y="3100.0"/> <port id="pr_8728fa11-4ed3-4232-8dbd-91d4023cfcd5_p1" x="10115.961" y="3090.0"/> <port id="pr_8728fa11-4ed3-4232-8dbd-91d4023cfcd5_p2" x="10115.961" y="3120.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_55011c9c-aac9-479b-930a-5770b543cdfb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22558232 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9915.5" y="3343.25"/> <port id="pr_55011c9c-aac9-479b-930a-5770b543cdfb_p1" x="9920.5" y="3333.25"/> <port id="pr_55011c9c-aac9-479b-930a-5770b543cdfb_p2" x="9920.5" y="3363.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_d00358e7-6b90-4178-9117-48a55f3a9060"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:16099633 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="9915.5" y="3554.5"/> <port id="pr_d00358e7-6b90-4178-9117-48a55f3a9060_p1" x="9920.5" y="3544.5"/> <port id="pr_d00358e7-6b90-4178-9117-48a55f3a9060_p2" x="9920.5" y="3574.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_654fb044-2326-4371-bc31-0320c665af86"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Phosphorylation of LRP6 by ERKk and simultanious activation by Wnt3 gives a higher activation rate of the canoncical wnt pathway (synergetic effect) PMID:22558232 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10463.5" y="2999.6653"/> <port id="pr_654fb044-2326-4371-bc31-0320c665af86_p1" x="10453.5" y="3004.6653"/> <port id="pr_654fb044-2326-4371-bc31-0320c665af86_p2" x="10483.5" y="3004.6653"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_87673f18-4066-4d87-8074-d49341f73746"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: B-catenin phosphorylated at this residues shows increased binding with Bcl9 (mouse homologue Bcl9-2) PMID:15371335 Apperently Bcl9 binds b-catenin independently of Y142 PMID:17113272 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10231.0" y="3577.3462"/> <port id="pr_87673f18-4066-4d87-8074-d49341f73746_p1" x="10221.0" y="3582.3462"/> <port id="pr_87673f18-4066-4d87-8074-d49341f73746_p2" x="10251.0" y="3582.3462"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_63ae3207-0b27-479b-bfde-0cee90bad359"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15526030 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10869.5" y="4060.5266"/> <port id="pr_63ae3207-0b27-479b-bfde-0cee90bad359_p1" x="10859.5" y="4065.5266"/> <port id="pr_63ae3207-0b27-479b-bfde-0cee90bad359_p2" x="10889.5" y="4065.5266"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_201ada39-bbdd-48af-8164-b44de56fb55f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15526030 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="11044.5" y="4060.5"/> <port id="pr_201ada39-bbdd-48af-8164-b44de56fb55f_p1" x="11034.5" y="4065.5"/> <port id="pr_201ada39-bbdd-48af-8164-b44de56fb55f_p2" x="11064.5" y="4065.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_cc8c6a5d-75e5-4fd6-93f6-6775aa75bf9c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19131971 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10988.5" y="4225.444"/> <port id="pr_cc8c6a5d-75e5-4fd6-93f6-6775aa75bf9c_p1" x="10978.5" y="4230.444"/> <port id="pr_cc8c6a5d-75e5-4fd6-93f6-6775aa75bf9c_p2" x="11008.5" y="4230.444"/> </glyph> <glyph class="process" orientation="vertical" id="pr_7f3c58cd-1427-44e3-98b1-618df10c1de5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19131971 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="11170.5" y="4341.5"/> <port id="pr_7f3c58cd-1427-44e3-98b1-618df10c1de5_p1" x="11175.5" y="4331.5"/> <port id="pr_7f3c58cd-1427-44e3-98b1-618df10c1de5_p2" x="11175.5" y="4361.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c475cc37-af32-46b8-8c3f-9dfe2d51f61f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19131971 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="11008.0" y="4457.0"/> <port id="pr_c475cc37-af32-46b8-8c3f-9dfe2d51f61f_p1" x="11028.0" y="4462.0"/> <port id="pr_c475cc37-af32-46b8-8c3f-9dfe2d51f61f_p2" x="10998.0" y="4462.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a9e5c390-07fe-4d0c-bedc-5e54e3d566f4"> <bbox w="10.0" h="10.0" x="10816.5" y="4527.2695"/> <port id="pr_a9e5c390-07fe-4d0c-bedc-5e54e3d566f4_p1" x="10836.5" y="4532.2695"/> <port id="pr_a9e5c390-07fe-4d0c-bedc-5e54e3d566f4_p2" x="10806.5" y="4532.2695"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_cc9e9a00-3053-4901-971c-d32a1b377fc1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:16969074 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10841.25" y="4584.0"/> <port id="pr_cc9e9a00-3053-4901-971c-d32a1b377fc1_p1" x="10831.25" y="4589.0"/> <port id="pr_cc9e9a00-3053-4901-971c-d32a1b377fc1_p2" x="10861.25" y="4589.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_025ec615-073b-41ca-bf88-98426f218123"> <bbox w="10.0" h="10.0" x="11000.625" y="4583.5874"/> <port id="pr_025ec615-073b-41ca-bf88-98426f218123_p1" x="10990.625" y="4588.5874"/> <port id="pr_025ec615-073b-41ca-bf88-98426f218123_p2" x="11020.625" y="4588.5874"/> </glyph> <glyph class="process" orientation="vertical" id="pr_7a6cb276-db2a-4efc-a4e0-523b3fd99ab2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:22745173 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="11099.0" y="4681.0"/> <port id="pr_7a6cb276-db2a-4efc-a4e0-523b3fd99ab2_p1" x="11104.0" y="4671.0"/> <port id="pr_7a6cb276-db2a-4efc-a4e0-523b3fd99ab2_p2" x="11104.0" y="4701.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ff292172-d956-49fb-b961-7ab7ce39a259"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:22745173 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10973.0" y="4734.5"/> <port id="pr_ff292172-d956-49fb-b961-7ab7ce39a259_p1" x="10978.0" y="4724.5"/> <port id="pr_ff292172-d956-49fb-b961-7ab7ce39a259_p2" x="10978.0" y="4754.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a5e26f23-be11-42f5-8cf2-a8839911a8af"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: c-Raf; MEK1/2; ERK1/2;HRAS PMID:19906679 TGF-b1 in airway smooth muscle cells PMID:21908588 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="11572.0" y="4009.0"/> <port id="pr_a5e26f23-be11-42f5-8cf2-a8839911a8af_p1" x="11562.0" y="4014.0"/> <port id="pr_a5e26f23-be11-42f5-8cf2-a8839911a8af_p2" x="11592.0" y="4014.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_582f3579-501c-4bf9-a229-2106f2e8c74e"> <bbox w="10.0" h="10.0" x="10933.113" y="3661.0"/> <port id="pr_582f3579-501c-4bf9-a229-2106f2e8c74e_p1" x="10953.113" y="3666.0"/> <port id="pr_582f3579-501c-4bf9-a229-2106f2e8c74e_p2" x="10923.113" y="3666.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_afd4cb8c-fd68-4303-9149-48e3f7e6ad95"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Complex of G-alpha12 and p120 stabilises binding of E-cadherin in Adhesion-complex. G-alpha12 is found back in complex with p120 and E-cadherin PMID:15240885 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10079.375" y="3230.5"/> <port id="pr_afd4cb8c-fd68-4303-9149-48e3f7e6ad95_p1" x="10099.375" y="3235.5"/> <port id="pr_afd4cb8c-fd68-4303-9149-48e3f7e6ad95_p2" x="10069.375" y="3235.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d1b90036-e011-4b39-8d59-96fc56fcf24f"> <bbox w="10.0" h="10.0" x="10359.25" y="3179.75"/> <port id="pr_d1b90036-e011-4b39-8d59-96fc56fcf24f_p1" x="10349.25" y="3184.75"/> <port id="pr_d1b90036-e011-4b39-8d59-96fc56fcf24f_p2" x="10379.25" y="3184.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5cba62cf-5972-42eb-aa49-76b2f35fa006"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: In airway smooth muscle cells PMID:21908588 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="11572.0" y="4058.0"/> <port id="pr_5cba62cf-5972-42eb-aa49-76b2f35fa006_p1" x="11562.0" y="4063.0"/> <port id="pr_5cba62cf-5972-42eb-aa49-76b2f35fa006_p2" x="11592.0" y="4063.0"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_d777375b-d6e7-4b9e-8b6a-4d430394eee2"> <bbox w="20.0" h="20.0" x="11151.666" y="3819.3335"/> <port id="logicglyph_d777375b-d6e7-4b9e-8b6a-4d430394eee2_p1" x="11141.666" y="3829.3335"/> <port id="logicglyph_d777375b-d6e7-4b9e-8b6a-4d430394eee2_p2" x="11181.666" y="3829.3335"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d8797906-6e63-4d4c-b2c7-852a727a0b5a"> <bbox w="10.0" h="10.0" x="11709.5" y="4058.0"/> <port id="pr_d8797906-6e63-4d4c-b2c7-852a727a0b5a_p1" x="11699.5" y="4063.0"/> <port id="pr_d8797906-6e63-4d4c-b2c7-852a727a0b5a_p2" x="11729.5" y="4063.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_b0fe125a-e04c-4bb1-98e0-1369f48dc933"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:21908588 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="11930.5" y="4057.5"/> <port id="pr_b0fe125a-e04c-4bb1-98e0-1369f48dc933_p1" x="11920.5" y="4062.5"/> <port id="pr_b0fe125a-e04c-4bb1-98e0-1369f48dc933_p2" x="11950.5" y="4062.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a4938bc8-4d64-4479-b644-df09a096596d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:15240885 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10377.22" y="3251.5"/> <port id="pr_a4938bc8-4d64-4479-b644-df09a096596d_p1" x="10382.22" y="3271.5"/> <port id="pr_a4938bc8-4d64-4479-b644-df09a096596d_p2" x="10382.22" y="3241.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ad6ff6b6-22e4-4ee0-a004-10d10e46c477"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:11136230 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10391.5" y="3339.5"/> <port id="pr_ad6ff6b6-22e4-4ee0-a004-10d10e46c477_p1" x="10381.5" y="3344.5"/> <port id="pr_ad6ff6b6-22e4-4ee0-a004-10d10e46c477_p2" x="10411.5" y="3344.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_0ff83e43-3ff4-4035-8165-75fa346974bc"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: binding of G-alpha12 toE-cadherin results of loss of binding of b-catenin from the adherence junction PMID:11136230 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10087.75" y="3270.25"/> <port id="pr_0ff83e43-3ff4-4035-8165-75fa346974bc_p1" x="10077.75" y="3275.25"/> <port id="pr_0ff83e43-3ff4-4035-8165-75fa346974bc_p2" x="10107.75" y="3275.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8e2710dc-c2cf-4d72-9a49-4ff83846d273"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:16868183 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10396.0" y="3493.6228"/> <port id="pr_8e2710dc-c2cf-4d72-9a49-4ff83846d273_p1" x="10386.0" y="3498.6228"/> <port id="pr_8e2710dc-c2cf-4d72-9a49-4ff83846d273_p2" x="10416.0" y="3498.6228"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a2cbb75e-12c3-4d76-acbf-ec20eff25c7d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Unknown which amino acid residue PMID:22399895 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10568.0" y="3130.5"/> <port id="pr_a2cbb75e-12c3-4d76-acbf-ec20eff25c7d_p1" x="10573.0" y="3150.5"/> <port id="pr_a2cbb75e-12c3-4d76-acbf-ec20eff25c7d_p2" x="10573.0" y="3120.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d539a053-8eb9-459c-9b37-5878a5fd7893"> <bbox w="10.0" h="10.0" x="10270.5" y="3064.0"/> <port id="pr_d539a053-8eb9-459c-9b37-5878a5fd7893_p1" x="10290.5" y="3069.0"/> <port id="pr_d539a053-8eb9-459c-9b37-5878a5fd7893_p2" x="10260.5" y="3069.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8a07a0f9-1025-4a35-9754-45641fe8bc5d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:22898821, References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10841.5" y="3043.8254"/> <port id="pr_8a07a0f9-1025-4a35-9754-45641fe8bc5d_p1" x="10831.5" y="3048.8254"/> <port id="pr_8a07a0f9-1025-4a35-9754-45641fe8bc5d_p2" x="10861.5" y="3048.8254"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b0a60752-d4d6-4395-9def-39340f1bf7d0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: Positive modulaion PMID:15755874, PMID:23308069 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10667.0" y="3303.0"/> <port id="pr_b0a60752-d4d6-4395-9def-39340f1bf7d0_p1" x="10672.0" y="3293.0"/> <port id="pr_b0a60752-d4d6-4395-9def-39340f1bf7d0_p2" x="10672.0" y="3323.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_fca2e6ce-0755-4f9d-a65b-7bb8c5fceb02"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:19900451 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10674.5" y="3184.5"/> <port id="pr_fca2e6ce-0755-4f9d-a65b-7bb8c5fceb02_p1" x="10664.5" y="3189.5"/> <port id="pr_fca2e6ce-0755-4f9d-a65b-7bb8c5fceb02_p2" x="10694.5" y="3189.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_787b4ee7-da40-487e-9a3d-66551accb1e1"> <bbox w="10.0" h="10.0" x="10730.0" y="3444.0"/> <port id="pr_787b4ee7-da40-487e-9a3d-66551accb1e1_p1" x="10720.0" y="3449.0"/> <port id="pr_787b4ee7-da40-487e-9a3d-66551accb1e1_p2" x="10750.0" y="3449.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a8733c95-581b-4c69-95a6-2fe759dcc9e5"> <bbox w="10.0" h="10.0" x="10889.0" y="3393.5"/> <port id="pr_a8733c95-581b-4c69-95a6-2fe759dcc9e5_p1" x="10894.0" y="3383.5"/> <port id="pr_a8733c95-581b-4c69-95a6-2fe759dcc9e5_p2" x="10894.0" y="3413.5"/> </glyph> <glyph class="uncertain process" orientation="horizontal" id="pr_7456d169-04b0-4dec-9a5a-de29c6213bb8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: transcription-independent apc-mediated apoptosis PMID:19900451, PMID:17297457 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10813.5" y="3531.0"/> <port id="pr_7456d169-04b0-4dec-9a5a-de29c6213bb8_p1" x="10833.5" y="3536.0"/> <port id="pr_7456d169-04b0-4dec-9a5a-de29c6213bb8_p2" x="10803.5" y="3536.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5f6ad765-50a9-4756-a63f-8e53afb0c695"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: The 40 kDa isoform has high affinity for cleaved APC, this results in decreased apoptsis PMID:19900451 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10907.354" y="3639.0"/> <port id="pr_5f6ad765-50a9-4756-a63f-8e53afb0c695_p1" x="10912.354" y="3629.0"/> <port id="pr_5f6ad765-50a9-4756-a63f-8e53afb0c695_p2" x="10912.354" y="3659.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_40ab64f9-97f4-4529-8538-d5c230c81333"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_NON_CANONICAL Maps_Modules_end References_begin: PMID:17588722 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="10423.104" y="3669.5"/> <port id="pr_40ab64f9-97f4-4529-8538-d5c230c81333_p1" x="10428.104" y="3659.5"/> <port id="pr_40ab64f9-97f4-4529-8538-d5c230c81333_p2" x="10428.104" y="3689.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1758ef67-a3ea-4384-9023-c8bdce59ed34"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17143292 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="12457.797" y="720.5"/> <port id="pr_1758ef67-a3ea-4384-9023-c8bdce59ed34_p1" x="12462.797" y="710.5"/> <port id="pr_1758ef67-a3ea-4384-9023-c8bdce59ed34_p2" x="12462.797" y="740.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c639c461-92bd-408a-99e4-0844e47d0f43"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12000790 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="12448.25" y="952.8125"/> <port id="pr_c639c461-92bd-408a-99e4-0844e47d0f43_p1" x="12453.25" y="942.8125"/> <port id="pr_c639c461-92bd-408a-99e4-0844e47d0f43_p2" x="12453.25" y="972.8125"/> </glyph> <glyph class="process" orientation="vertical" id="pr_6902a6a3-24c7-4c4f-ba1d-5c976fd9e55a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11955436 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="12448.0" y="1176.2812"/> <port id="pr_6902a6a3-24c7-4c4f-ba1d-5c976fd9e55a_p1" x="12453.0" y="1166.2812"/> <port id="pr_6902a6a3-24c7-4c4f-ba1d-5c976fd9e55a_p2" x="12453.0" y="1196.2812"/> </glyph> <glyph class="process" orientation="vertical" id="pr_943cb431-4ed0-45ac-b997-04c2af662a4a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11955436 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="12448.25" y="1395.0938"/> <port id="pr_943cb431-4ed0-45ac-b997-04c2af662a4a_p1" x="12453.25" y="1385.0938"/> <port id="pr_943cb431-4ed0-45ac-b997-04c2af662a4a_p2" x="12453.25" y="1415.0938"/> </glyph> <glyph class="process" orientation="vertical" id="pr_447beb0f-0656-48f2-aad9-316a6deab6d2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11955436 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="12448.25" y="1612.4062"/> <port id="pr_447beb0f-0656-48f2-aad9-316a6deab6d2_p1" x="12453.25" y="1602.4062"/> <port id="pr_447beb0f-0656-48f2-aad9-316a6deab6d2_p2" x="12453.25" y="1632.4062"/> </glyph> <glyph class="process" orientation="vertical" id="pr_375b3849-b62b-4e2b-8c86-7d821f497b0f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17910481 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="12448.0" y="1835.2188"/> <port id="pr_375b3849-b62b-4e2b-8c86-7d821f497b0f_p1" x="12453.0" y="1825.2188"/> <port id="pr_375b3849-b62b-4e2b-8c86-7d821f497b0f_p2" x="12453.0" y="1855.2188"/> </glyph> <glyph class="process" orientation="vertical" id="pr_62298677-32da-4155-8b43-33bc1f9df0a1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17910481 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="12447.5" y="2065.5312"/> <port id="pr_62298677-32da-4155-8b43-33bc1f9df0a1_p1" x="12452.5" y="2055.5312"/> <port id="pr_62298677-32da-4155-8b43-33bc1f9df0a1_p2" x="12452.5" y="2085.5312"/> </glyph> <glyph class="process" orientation="vertical" id="pr_0838dddf-244f-46d1-a9eb-498e12ec2018"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17910481 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="12447.5" y="2291.8438"/> <port id="pr_0838dddf-244f-46d1-a9eb-498e12ec2018_p1" x="12452.5" y="2281.8438"/> <port id="pr_0838dddf-244f-46d1-a9eb-498e12ec2018_p2" x="12452.5" y="2311.8438"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f438d5cf-c705-41aa-9a0b-08b9c45992b9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17910481 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="12644.416" y="2404.0"/> <port id="pr_f438d5cf-c705-41aa-9a0b-08b9c45992b9_p1" x="12634.416" y="2409.0"/> <port id="pr_f438d5cf-c705-41aa-9a0b-08b9c45992b9_p2" x="12664.416" y="2409.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8711dbf9-9f40-4730-aad0-44d1b425ce45"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17910481 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="12985.75" y="2404.0"/> <port id="pr_8711dbf9-9f40-4730-aad0-44d1b425ce45_p1" x="12975.75" y="2409.0"/> <port id="pr_8711dbf9-9f40-4730-aad0-44d1b425ce45_p2" x="13005.75" y="2409.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_4e9dffb5-f258-48ab-8914-23a3c3a0d707"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:10581160 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="12569.625" y="337.5"/> <port id="pr_4e9dffb5-f258-48ab-8914-23a3c3a0d707_p1" x="12574.625" y="327.5"/> <port id="pr_4e9dffb5-f258-48ab-8914-23a3c3a0d707_p2" x="12574.625" y="357.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_65e0684b-8497-4f3c-a447-3beb708b8cc1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:10581160 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="12448.0" y="483.0"/> <port id="pr_65e0684b-8497-4f3c-a447-3beb708b8cc1_p1" x="12453.0" y="473.0"/> <port id="pr_65e0684b-8497-4f3c-a447-3beb708b8cc1_p2" x="12453.0" y="503.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ab8033f4-574a-47ff-8eeb-b0531c69ae27"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17318175 PMID:19581931 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="12949.0" y="590.6538"/> <port id="pr_ab8033f4-574a-47ff-8eeb-b0531c69ae27_p1" x="12939.0" y="595.6538"/> <port id="pr_ab8033f4-574a-47ff-8eeb-b0531c69ae27_p2" x="12969.0" y="595.6538"/> </glyph> <glyph class="process" orientation="vertical" id="pr_52863cd9-e859-46dc-995d-97dddbac80a9"> <bbox w="10.0" h="10.0" x="13086.25" y="706.25"/> <port id="pr_52863cd9-e859-46dc-995d-97dddbac80a9_p1" x="13091.25" y="696.25"/> <port id="pr_52863cd9-e859-46dc-995d-97dddbac80a9_p2" x="13091.25" y="726.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_9f5f3687-a094-4599-99e9-14d3e2879e78"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17318175 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="12960.777" y="802.8633"/> <port id="pr_9f5f3687-a094-4599-99e9-14d3e2879e78_p1" x="12965.777" y="822.8633"/> <port id="pr_9f5f3687-a094-4599-99e9-14d3e2879e78_p2" x="12965.777" y="792.8633"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_966018ce-0c9e-4ffd-b39b-e8efab1c895d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19556239 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="12795.0" y="1712.761"/> <port id="pr_966018ce-0c9e-4ffd-b39b-e8efab1c895d_p1" x="12785.0" y="1717.761"/> <port id="pr_966018ce-0c9e-4ffd-b39b-e8efab1c895d_p2" x="12815.0" y="1717.761"/> </glyph> <glyph class="process" orientation="vertical" id="pr_f8c6c2f4-7dc2-4262-b488-c1a55006048f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19556239 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="12976.5" y="1597.5"/> <port id="pr_f8c6c2f4-7dc2-4262-b488-c1a55006048f_p1" x="12981.5" y="1617.5"/> <port id="pr_f8c6c2f4-7dc2-4262-b488-c1a55006048f_p2" x="12981.5" y="1587.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c51fa054-ec19-4d4d-b469-2476cbd7b684"> <bbox w="10.0" h="10.0" x="12955.854" y="1332.0"/> <port id="pr_c51fa054-ec19-4d4d-b469-2476cbd7b684_p1" x="12960.854" y="1352.0"/> <port id="pr_c51fa054-ec19-4d4d-b469-2476cbd7b684_p2" x="12960.854" y="1322.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_81b06769-fe5f-48d0-8ec0-63ebd5e7ab0e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21606194 PMID:19705439 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13503.598" y="212.53708"/> <port id="pr_81b06769-fe5f-48d0-8ec0-63ebd5e7ab0e_p1" x="13493.598" y="217.53708"/> <port id="pr_81b06769-fe5f-48d0-8ec0-63ebd5e7ab0e_p2" x="13523.598" y="217.53708"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_da22cb5c-c100-4b07-919b-3b906e29b95e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:16707567 PMID:21285348 DVL is primed by CK2 and/or MARK2 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13377.375" y="576.0"/> <port id="pr_da22cb5c-c100-4b07-919b-3b906e29b95e_p1" x="13367.375" y="581.0"/> <port id="pr_da22cb5c-c100-4b07-919b-3b906e29b95e_p2" x="13397.375" y="581.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_7c3de2dd-aa06-456d-90eb-411efa413df8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20006983 PMID:16965538 PMID:210606194 PMID:20093472 PMID:21796133 Phosphorylation of DVL by CK1 epsilon. Activation of CK1 epsilon by unknown factor An acidic environment is required for phosphorylation of DVL and LRP5/6 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14241.25" y="217.02548"/> <port id="pr_7c3de2dd-aa06-456d-90eb-411efa413df8_p1" x="14231.25" y="222.02548"/> <port id="pr_7c3de2dd-aa06-456d-90eb-411efa413df8_p2" x="14261.25" y="222.02548"/> </glyph> <glyph class="process" orientation="vertical" id="pr_946da9d8-90ed-44ff-ab9d-d7c78799a782"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19705439 PMID:17426148 Beta-ARRESTIN binds to phosphorylated DVL References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13601.525" y="612.5"/> <port id="pr_946da9d8-90ed-44ff-ab9d-d7c78799a782_p1" x="13606.525" y="602.5"/> <port id="pr_946da9d8-90ed-44ff-ab9d-d7c78799a782_p2" x="13606.525" y="632.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_2ddc6798-62d0-40fd-beea-da4b6ce657e7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19561074 PI4KIIalpha and PIP5KIbeta are in complex together with DVL. To keep complex clear the enzymes are left outside of this complex References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15058.0" y="541.5"/> <port id="pr_2ddc6798-62d0-40fd-beea-da4b6ce657e7_p1" x="15063.0" y="531.5"/> <port id="pr_2ddc6798-62d0-40fd-beea-da4b6ce657e7_p2" x="15063.0" y="561.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_bb709b51-c7be-451a-b8a6-5302f66699f1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19561074 PI4KIIalpha and PIP5KIbeta are in complex together with DVL. To keep complex clear the enzymes are left outside of this complex References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15062.0" y="649.0"/> <port id="pr_bb709b51-c7be-451a-b8a6-5302f66699f1_p1" x="15067.0" y="639.0"/> <port id="pr_bb709b51-c7be-451a-b8a6-5302f66699f1_p2" x="15067.0" y="669.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_7c3ee7b4-c87e-4b64-83db-0c0d5b77aef0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17569865 PMID:20229235 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14632.25" y="217.25"/> <port id="pr_7c3ee7b4-c87e-4b64-83db-0c0d5b77aef0_p1" x="14622.25" y="222.25"/> <port id="pr_7c3ee7b4-c87e-4b64-83db-0c0d5b77aef0_p2" x="14652.25" y="222.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_16eadab6-1b1e-4210-9d02-e4ca08d5048f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19561074 PMID:20460648 PMID:19581931 PMID:21304492 PMID:21498506 AMER1 recruits axin References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14455.0" y="487.5"/> <port id="pr_16eadab6-1b1e-4210-9d02-e4ca08d5048f_p1" x="14475.0" y="492.5"/> <port id="pr_16eadab6-1b1e-4210-9d02-e4ca08d5048f_p2" x="14445.0" y="492.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_319e970c-086e-423f-b630-e2e71af4b5a1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21498506 Membrane-bound AMER1 acts as scaffold and brings APC to the membrane References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13096.577" y="590.25"/> <port id="pr_319e970c-086e-423f-b630-e2e71af4b5a1_p1" x="13101.577" y="610.25"/> <port id="pr_319e970c-086e-423f-b630-e2e71af4b5a1_p2" x="13101.577" y="580.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_25eb4521-af1f-4669-8775-11b9f7fe4268"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20229235 PMID:18077588 PMID:20059949 PMID:20627573 ANNOTATION:GSK3 phosphorylates first LRP @ S1490 followed by CK1 in the repeat PPSP A ANNOTATION:CYCLINY/PFTK complex is able to phosphorylate s1490 on LRP6 which primes the receptor for CK1 phosphorylisation. The complex is present during G2/M phase and stimulates wnt signalling it has synergetic effect together with the wnt ligand WNT/b-catenin signalling oscillates durring cell cycle and peaks at G2/M References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14343.0" y="796.0"/> <port id="pr_25eb4521-af1f-4669-8775-11b9f7fe4268_p1" x="14333.0" y="801.0"/> <port id="pr_25eb4521-af1f-4669-8775-11b9f7fe4268_p2" x="14363.0" y="801.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_de6c1d53-e695-4b61-a3ce-d86a6015a332"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20229235 PMID:18077588 PMID:21304492 PMID:21498506 Phosphorylation of the repeat PPSP A allows recruitment of additional GSK/AXIN which phosphorylates LRP5/6 on other PPSP repeats resulting of sequestering of GSK3 and AXIN away from the destruction complex AMER1 recruits axin and GSk3 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14599.25" y="972.25"/> <port id="pr_de6c1d53-e695-4b61-a3ce-d86a6015a332_p1" x="14604.25" y="962.25"/> <port id="pr_de6c1d53-e695-4b61-a3ce-d86a6015a332_p2" x="14604.25" y="992.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c93e1397-17c9-4262-8af9-c37b058c5048"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20229235 PMID:18077588 ANNOTATION:GSK3 phosphorylates first @ S1490 followed by CK1 in the repeat PPSP A References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14328.5" y="1167.75"/> <port id="pr_c93e1397-17c9-4262-8af9-c37b058c5048_p1" x="14348.5" y="1172.75"/> <port id="pr_c93e1397-17c9-4262-8af9-c37b058c5048_p2" x="14318.5" y="1172.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_d9ba20da-1465-4480-ac60-2c33a8da943c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21606194 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13430.576" y="1053.625"/> <port id="pr_d9ba20da-1465-4480-ac60-2c33a8da943c_p1" x="13435.576" y="1073.625"/> <port id="pr_d9ba20da-1465-4480-ac60-2c33a8da943c_p2" x="13435.576" y="1043.625"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c934cad9-0557-4913-bfde-6379325a0154"> <bbox w="10.0" h="10.0" x="14077.0" y="1462.0"/> <port id="pr_c934cad9-0557-4913-bfde-6379325a0154_p1" x="14082.0" y="1452.0"/> <port id="pr_c934cad9-0557-4913-bfde-6379325a0154_p2" x="14082.0" y="1482.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_376c2f21-6219-4994-abaf-a58829b76e4b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21606194 ANNOTATION:CK1alpha phosphorylates E-CADHERIN on unkown residue and p-120 catenin References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14366.5" y="1759.75"/> <port id="pr_376c2f21-6219-4994-abaf-a58829b76e4b_p1" x="14356.5" y="1764.75"/> <port id="pr_376c2f21-6219-4994-abaf-a58829b76e4b_p2" x="14386.5" y="1764.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b4b35622-3b80-413c-b73f-f087b66b9450"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21606194 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14652.174" y="1994.75"/> <port id="pr_b4b35622-3b80-413c-b73f-f087b66b9450_p1" x="14657.174" y="1984.75"/> <port id="pr_b4b35622-3b80-413c-b73f-f087b66b9450_p2" x="14657.174" y="2014.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_adea9836-ac39-4c0e-a32d-20821e626a05"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21606194 PMID:21285348 DVL is again phosphorylated to form PS-DVL. This isoform of DVL leads to depolimerisation of DVL and even distribution in the cell. Which CK1 isoform catalyses this reaction is unknown References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14285.132" y="2277.25"/> <port id="pr_adea9836-ac39-4c0e-a32d-20821e626a05_p1" x="14290.132" y="2267.25"/> <port id="pr_adea9836-ac39-4c0e-a32d-20821e626a05_p2" x="14290.132" y="2297.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_53ea2870-09b3-4780-8dce-34711301735d"> <bbox w="10.0" h="10.0" x="12801.875" y="303.5"/> <port id="pr_53ea2870-09b3-4780-8dce-34711301735d_p1" x="12821.875" y="308.5"/> <port id="pr_53ea2870-09b3-4780-8dce-34711301735d_p2" x="12791.875" y="308.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_4d4241f8-eec1-48ee-9a8c-f594c5e74b33"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20460648 PMID:18077588 PMID:19705439 PMID:17426148 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13560.75" y="963.7259"/> <port id="pr_4d4241f8-eec1-48ee-9a8c-f594c5e74b33_p1" x="13550.75" y="968.7259"/> <port id="pr_4d4241f8-eec1-48ee-9a8c-f594c5e74b33_p2" x="13580.75" y="968.7259"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_590515a1-77d7-47ec-9fc7-01c044ec89db"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15688063 PMID:22730322 FAF1 acts as scaffold protein References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="12959.969" y="2173.6284"/> <port id="pr_590515a1-77d7-47ec-9fc7-01c044ec89db_p1" x="12949.969" y="2178.6284"/> <port id="pr_590515a1-77d7-47ec-9fc7-01c044ec89db_p2" x="12979.969" y="2178.6284"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_1d3fff2d-b8e1-41f9-8d51-8997174ef9ee"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19576224 PMID:17143292 PMID:10023660 PMID:21411632 PMID:22730322 PMID:22682247 FAF1 enhances poly-ubiquitination of beta-catenin by acting as scaffold protein Intact destruction complex in the proteosome complex References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13291.541" y="2196.8257"/> <port id="pr_1d3fff2d-b8e1-41f9-8d51-8997174ef9ee_p1" x="13281.541" y="2201.8257"/> <port id="pr_1d3fff2d-b8e1-41f9-8d51-8997174ef9ee_p2" x="13311.541" y="2201.8257"/> </glyph> <glyph class="process" orientation="vertical" id="pr_0d71267c-98c8-415c-afcd-b432c2f31362"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19576224 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13407.638" y="1866.25"/> <port id="pr_0d71267c-98c8-415c-afcd-b432c2f31362_p1" x="13412.638" y="1886.25"/> <port id="pr_0d71267c-98c8-415c-afcd-b432c2f31362_p2" x="13412.638" y="1856.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_7f88b79c-9cd5-4adf-8a26-ec816ecbba18"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:16547521 In the presence of WNT3a DVL-3 forms complex with KLHL12/CUL3/RBX1-complex References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="12862.754" y="904.75"/> <port id="pr_7f88b79c-9cd5-4adf-8a26-ec816ecbba18_p1" x="12867.754" y="894.75"/> <port id="pr_7f88b79c-9cd5-4adf-8a26-ec816ecbba18_p2" x="12867.754" y="924.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a6b36ad8-67c0-413d-9e1f-edcb93a60a5c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15852005 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="12754.643" y="1247.0"/> <port id="pr_a6b36ad8-67c0-413d-9e1f-edcb93a60a5c_p1" x="12759.643" y="1237.0"/> <port id="pr_a6b36ad8-67c0-413d-9e1f-edcb93a60a5c_p2" x="12759.643" y="1267.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_053cc335-7aac-452f-a054-ff714683dca8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15852005 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="12933.25" y="735.0"/> <port id="pr_053cc335-7aac-452f-a054-ff714683dca8_p1" x="12938.25" y="755.0"/> <port id="pr_053cc335-7aac-452f-a054-ff714683dca8_p2" x="12938.25" y="725.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_22d3a885-7a9f-45d2-bba4-099c37660441"> <bbox w="10.0" h="10.0" x="13125.5" y="1033.0"/> <port id="pr_22d3a885-7a9f-45d2-bba4-099c37660441_p1" x="13115.5" y="1038.0"/> <port id="pr_22d3a885-7a9f-45d2-bba4-099c37660441_p2" x="13145.5" y="1038.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_9c92ceb4-27c4-4fe7-be0c-3d234e0fc889"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19718039 PMID:21602792 In presence of WNT ligand References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13181.25" y="596.0"/> <port id="pr_9c92ceb4-27c4-4fe7-be0c-3d234e0fc889_p1" x="13186.25" y="616.0"/> <port id="pr_9c92ceb4-27c4-4fe7-be0c-3d234e0fc889_p2" x="13186.25" y="586.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_75d2edfe-2070-4a4a-9170-a637657e11c0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21602792 In presence of WNT ligand References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13140.25" y="698.0"/> <port id="pr_75d2edfe-2070-4a4a-9170-a637657e11c0_p1" x="13145.25" y="688.0"/> <port id="pr_75d2edfe-2070-4a4a-9170-a637657e11c0_p2" x="13145.25" y="718.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_0794e9b6-9527-4a59-949e-eb4f53a0c34c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21304492 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15062.558" y="758.0"/> <port id="pr_0794e9b6-9527-4a59-949e-eb4f53a0c34c_p1" x="15067.558" y="748.0"/> <port id="pr_0794e9b6-9527-4a59-949e-eb4f53a0c34c_p2" x="15067.558" y="778.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_3271cbef-f78a-43a6-b83b-7cf71f77363a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21304492 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15063.3" y="898.5"/> <port id="pr_3271cbef-f78a-43a6-b83b-7cf71f77363a_p1" x="15068.3" y="888.5"/> <port id="pr_3271cbef-f78a-43a6-b83b-7cf71f77363a_p2" x="15068.3" y="918.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_66398852-d58b-4856-8545-ab9953ba9684"> <bbox w="10.0" h="10.0" x="14051.709" y="2651.75"/> <port id="pr_66398852-d58b-4856-8545-ab9953ba9684_p1" x="14056.709" y="2641.75"/> <port id="pr_66398852-d58b-4856-8545-ab9953ba9684_p2" x="14056.709" y="2671.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_dcd6f625-e402-43bf-bf04-da0f87a64d6d"> <bbox w="10.0" h="10.0" x="14098.291" y="2651.75"/> <port id="pr_dcd6f625-e402-43bf-bf04-da0f87a64d6d_p1" x="14088.291" y="2656.75"/> <port id="pr_dcd6f625-e402-43bf-bf04-da0f87a64d6d_p2" x="14118.291" y="2656.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2f22eba9-085a-431b-a4b9-981646823964"> <bbox w="10.0" h="10.0" x="14438.637" y="2658.5"/> <port id="pr_2f22eba9-085a-431b-a4b9-981646823964_p1" x="14458.637" y="2663.5"/> <port id="pr_2f22eba9-085a-431b-a4b9-981646823964_p2" x="14428.637" y="2663.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f74d9907-5595-44ce-be64-bbd1af28eb4d"> <bbox w="10.0" h="10.0" x="14484.996" y="2658.5"/> <port id="pr_f74d9907-5595-44ce-be64-bbd1af28eb4d_p1" x="14504.996" y="2663.5"/> <port id="pr_f74d9907-5595-44ce-be64-bbd1af28eb4d_p2" x="14474.996" y="2663.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6e6cdde9-186a-40a2-a25b-e3ca4caef0e6"> <bbox w="10.0" h="10.0" x="14539.0" y="2652.989"/> <port id="pr_6e6cdde9-186a-40a2-a25b-e3ca4caef0e6_p1" x="14559.0" y="2657.989"/> <port id="pr_6e6cdde9-186a-40a2-a25b-e3ca4caef0e6_p2" x="14529.0" y="2657.989"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_500c5892-57b5-4da1-a765-1ffa732365af"> <bbox w="10.0" h="10.0" x="14589.0" y="2652.038"/> <port id="pr_500c5892-57b5-4da1-a765-1ffa732365af_p1" x="14609.0" y="2657.038"/> <port id="pr_500c5892-57b5-4da1-a765-1ffa732365af_p2" x="14579.0" y="2657.038"/> </glyph> <glyph class="process" orientation="vertical" id="pr_0473c986-ee98-41a0-9514-54d3688fec8e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20562099 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13733.0" y="776.5"/> <port id="pr_0473c986-ee98-41a0-9514-54d3688fec8e_p1" x="13738.0" y="766.5"/> <port id="pr_0473c986-ee98-41a0-9514-54d3688fec8e_p2" x="13738.0" y="796.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_17f1f7ed-8a8b-47ec-a5e5-a7540591054a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20093472 PRR binds to subunits ATP6V0C and D those are subunits of the V-ATPase. References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14001.5" y="443.0"/> <port id="pr_17f1f7ed-8a8b-47ec-a5e5-a7540591054a_p1" x="13991.5" y="448.0"/> <port id="pr_17f1f7ed-8a8b-47ec-a5e5-a7540591054a_p2" x="14021.5" y="448.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_2ad8ce53-f7f7-4a0c-adb4-ee86320e1bfa"> <bbox w="10.0" h="10.0" x="14099.5" y="443.0"/> <port id="pr_2ad8ce53-f7f7-4a0c-adb4-ee86320e1bfa_p1" x="14104.5" y="463.0"/> <port id="pr_2ad8ce53-f7f7-4a0c-adb4-ee86320e1bfa_p2" x="14104.5" y="433.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_bd2b32ed-81c1-4f59-8059-0a2343065c6c"> <bbox w="10.0" h="10.0" x="14145.805" y="2451.0205"/> <port id="pr_bd2b32ed-81c1-4f59-8059-0a2343065c6c_p1" x="14135.805" y="2456.0205"/> <port id="pr_bd2b32ed-81c1-4f59-8059-0a2343065c6c_p2" x="14165.805" y="2456.0205"/> </glyph> <glyph class="process" orientation="vertical" id="pr_20df6b23-8e37-4f02-880c-72cc833abfd7"> <bbox w="10.0" h="10.0" x="13484.671" y="450.5"/> <port id="pr_20df6b23-8e37-4f02-880c-72cc833abfd7_p1" x="13489.671" y="440.5"/> <port id="pr_20df6b23-8e37-4f02-880c-72cc833abfd7_p2" x="13489.671" y="470.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_fb95432b-cc3a-4d33-b2d6-8192f63d22bc"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21498506 PMID:17925382 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13279.0" y="1256.0"/> <port id="pr_fb95432b-cc3a-4d33-b2d6-8192f63d22bc_p1" x="13299.0" y="1261.0"/> <port id="pr_fb95432b-cc3a-4d33-b2d6-8192f63d22bc_p2" x="13269.0" y="1261.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_08478277-d748-4084-b204-13edb01da731"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22100263 5T4 forms complex with LRP6 resulting in inhibition of the canonical wnt References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15065.022" y="1270.536"/> <port id="pr_08478277-d748-4084-b204-13edb01da731_p1" x="15070.022" y="1260.536"/> <port id="pr_08478277-d748-4084-b204-13edb01da731_p2" x="15070.022" y="1290.536"/> </glyph> <glyph class="process" orientation="vertical" id="pr_6325609a-96a5-430a-8e57-86d04374a906"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11113207 PMID:18931698 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13321.27" y="472.0"/> <port id="pr_6325609a-96a5-430a-8e57-86d04374a906_p1" x="13326.27" y="492.0"/> <port id="pr_6325609a-96a5-430a-8e57-86d04374a906_p2" x="13326.27" y="462.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_90dfc642-fc16-4ab6-9f03-9be49b2190a4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21490931 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15683.5" y="806.0"/> <port id="pr_90dfc642-fc16-4ab6-9f03-9be49b2190a4_p1" x="15703.5" y="811.0"/> <port id="pr_90dfc642-fc16-4ab6-9f03-9be49b2190a4_p2" x="15673.5" y="811.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_e71f108c-6624-478a-b45a-eb028bad4299"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21490931 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15835.25" y="806.0"/> <port id="pr_e71f108c-6624-478a-b45a-eb028bad4299_p1" x="15825.25" y="811.0"/> <port id="pr_e71f108c-6624-478a-b45a-eb028bad4299_p2" x="15855.25" y="811.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_831c5040-3920-439b-b595-7a511c4a8bb6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: The protein is Parsylated but cannot be depicted as such in the program. Glutamic acids are parsylated. PMID:17825467 Both TNKS are required for parsylation of AXIN1/2 PMID:19759537 PMID:21799911 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="17038.0" y="1222.0"/> <port id="pr_831c5040-3920-439b-b595-7a511c4a8bb6_p1" x="17028.0" y="1227.0"/> <port id="pr_831c5040-3920-439b-b595-7a511c4a8bb6_p2" x="17058.0" y="1227.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_5216a645-ca8c-41c5-bb90-24f9986cd171"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19759537 PMID:21799911 PMID:21478859 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="17225.5" y="1222.0"/> <port id="pr_5216a645-ca8c-41c5-bb90-24f9986cd171_p1" x="17215.5" y="1227.0"/> <port id="pr_5216a645-ca8c-41c5-bb90-24f9986cd171_p2" x="17245.5" y="1227.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_ac6121be-42c8-44b4-95b2-a3b9b5b2a23b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19759537 PMID:21799911 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="17409.0" y="1223.2936"/> <port id="pr_ac6121be-42c8-44b4-95b2-a3b9b5b2a23b_p1" x="17399.0" y="1228.2936"/> <port id="pr_ac6121be-42c8-44b4-95b2-a3b9b5b2a23b_p2" x="17429.0" y="1228.2936"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_403fe015-da00-4ad8-afb4-3167269ba8b3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19759537 PMID:21799911 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="16963.25" y="1105.0"/> <port id="pr_403fe015-da00-4ad8-afb4-3167269ba8b3_p1" x="16983.25" y="1110.0"/> <port id="pr_403fe015-da00-4ad8-afb4-3167269ba8b3_p2" x="16953.25" y="1110.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_7e6a7e18-c78d-4645-afa0-6895ccc17d59"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19759537 PMID:21799911 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="16964.75" y="1345.5"/> <port id="pr_7e6a7e18-c78d-4645-afa0-6895ccc17d59_p1" x="16984.75" y="1350.5"/> <port id="pr_7e6a7e18-c78d-4645-afa0-6895ccc17d59_p2" x="16954.75" y="1350.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_e3aff89b-6b96-4cce-bc75-b2f77f3d91ec"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19759537 PMID:21799911 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="17224.5" y="1091.0"/> <port id="pr_e3aff89b-6b96-4cce-bc75-b2f77f3d91ec_p1" x="17229.5" y="1111.0"/> <port id="pr_e3aff89b-6b96-4cce-bc75-b2f77f3d91ec_p2" x="17229.5" y="1081.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_98e803ba-14b6-4879-b13e-19a59dbb8652"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19759537 PMID:21799911 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="17005.0" y="1060.0"/> <port id="pr_98e803ba-14b6-4879-b13e-19a59dbb8652_p1" x="16995.0" y="1065.0"/> <port id="pr_98e803ba-14b6-4879-b13e-19a59dbb8652_p2" x="17025.0" y="1065.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_6211af37-0c7c-44a7-87f0-08436a3253f8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19759537 PMID:21799911 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="17024.0" y="1393.0"/> <port id="pr_6211af37-0c7c-44a7-87f0-08436a3253f8_p1" x="17014.0" y="1398.0"/> <port id="pr_6211af37-0c7c-44a7-87f0-08436a3253f8_p2" x="17044.0" y="1398.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_827cf4a9-9a11-49a3-bc83-5b050ddaf712"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19759537 PMID:21799911 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="17293.5" y="1052.0"/> <port id="pr_827cf4a9-9a11-49a3-bc83-5b050ddaf712_p1" x="17283.5" y="1057.0"/> <port id="pr_827cf4a9-9a11-49a3-bc83-5b050ddaf712_p2" x="17313.5" y="1057.0"/> </glyph> <glyph class="omitted process" orientation="vertical" id="pr_f7df33da-f809-4786-84ab-93bae9675e0d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19759537 PMID:21799911 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="17433.781" y="1131.0"/> <port id="pr_f7df33da-f809-4786-84ab-93bae9675e0d_p1" x="17438.781" y="1121.0"/> <port id="pr_f7df33da-f809-4786-84ab-93bae9675e0d_p2" x="17438.781" y="1151.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_26307717-0271-4095-9595-0821de8b9e5a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19759537 PMID:21799911 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="17288.75" y="1138.9592"/> <port id="pr_26307717-0271-4095-9595-0821de8b9e5a_p1" x="17278.75" y="1143.9592"/> <port id="pr_26307717-0271-4095-9595-0821de8b9e5a_p2" x="17308.75" y="1143.9592"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_70f4a23c-a7e9-4ca7-a1f4-cc4e3fc72401"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19759537 PMID:21799911 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="17306.25" y="1313.0063"/> <port id="pr_70f4a23c-a7e9-4ca7-a1f4-cc4e3fc72401_p1" x="17296.25" y="1318.0063"/> <port id="pr_70f4a23c-a7e9-4ca7-a1f4-cc4e3fc72401_p2" x="17326.25" y="1318.0063"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_3fc73ec2-68fe-4b9b-92fb-edff69266393"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11433302 PMID:11448771 PMID:12050670 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="16229.5" y="762.5763"/> <port id="pr_3fc73ec2-68fe-4b9b-92fb-edff69266393_p1" x="16219.5" y="767.5763"/> <port id="pr_3fc73ec2-68fe-4b9b-92fb-edff69266393_p2" x="16249.5" y="767.5763"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_35cd871b-a2b0-4300-910b-2fc06b1ef218"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: DKK1 can disrupt binding of Fz/LRP6/WNT complex PMID:11448771 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="16682.5" y="773.89685"/> <port id="pr_35cd871b-a2b0-4300-910b-2fc06b1ef218_p1" x="16672.5" y="778.89685"/> <port id="pr_35cd871b-a2b0-4300-910b-2fc06b1ef218_p2" x="16702.5" y="778.89685"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b86afff9-8918-42dc-9117-9fffaffa2ce0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20543981 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="16333.0" y="886.5"/> <port id="pr_b86afff9-8918-42dc-9117-9fffaffa2ce0_p1" x="16338.0" y="876.5"/> <port id="pr_b86afff9-8918-42dc-9117-9fffaffa2ce0_p2" x="16338.0" y="906.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_27b7c911-a2f3-4f76-a3f6-0d8e646b83c5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:17804805 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="16868.5" y="691.85803"/> <port id="pr_27b7c911-a2f3-4f76-a3f6-0d8e646b83c5_p1" x="16858.5" y="696.85803"/> <port id="pr_27b7c911-a2f3-4f76-a3f6-0d8e646b83c5_p2" x="16888.5" y="696.85803"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_a7b0e7ad-5849-4885-b6aa-3dc0d16ed301"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Kremen interacts w/ RSPO1 thereby releasing LRP5/6 which can is used for canonical wnt signalling PMID:12050670 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="16903.0" y="788.75"/> <port id="pr_a7b0e7ad-5849-4885-b6aa-3dc0d16ed301_p1" x="16923.0" y="793.75"/> <port id="pr_a7b0e7ad-5849-4885-b6aa-3dc0d16ed301_p2" x="16893.0" y="793.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_f930ebfe-eeac-43a2-b375-b54bcaf812dc"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20370576 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="16061.444" y="739.0"/> <port id="pr_f930ebfe-eeac-43a2-b375-b54bcaf812dc_p1" x="16066.444" y="729.0"/> <port id="pr_f930ebfe-eeac-43a2-b375-b54bcaf812dc_p2" x="16066.444" y="759.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b33bd06a-67d3-420d-9551-e1e82eb7cdd1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20370576 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="16090.5" y="886.5"/> <port id="pr_b33bd06a-67d3-420d-9551-e1e82eb7cdd1_p1" x="16095.5" y="876.5"/> <port id="pr_b33bd06a-67d3-420d-9551-e1e82eb7cdd1_p2" x="16095.5" y="906.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6b225572-fa26-4837-8865-0d6ac83856a1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12734397 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="17007.0" y="892.84454"/> <port id="pr_6b225572-fa26-4837-8865-0d6ac83856a1_p1" x="17027.0" y="897.84454"/> <port id="pr_6b225572-fa26-4837-8865-0d6ac83856a1_p2" x="16997.0" y="897.84454"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8c5ae994-f3a2-4569-80cd-8cdc1ed8e3d8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Shown in Xenopus embryos that dimerisation of XFZ3 correlates with activation. This phenomenon is described once in: PMID:12734397 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="17353.25" y="778.0"/> <port id="pr_8c5ae994-f3a2-4569-80cd-8cdc1ed8e3d8_p1" x="17343.25" y="783.0"/> <port id="pr_8c5ae994-f3a2-4569-80cd-8cdc1ed8e3d8_p2" x="17373.25" y="783.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_3b3f88fe-e4f0-46da-a52e-cac40d147cbb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: XFZ7 is normally a monomer howerver upon forced dimerisation the receptor gets activated. This phenomenom is described once in: PMID:12734397 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="17683.0" y="827.5"/> <port id="pr_3b3f88fe-e4f0-46da-a52e-cac40d147cbb_p1" x="17688.0" y="817.5"/> <port id="pr_3b3f88fe-e4f0-46da-a52e-cac40d147cbb_p2" x="17688.0" y="847.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8cf2d23f-fdeb-4bc9-b263-2868f1edaf1f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12734397 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="17117.0" y="923.03973"/> <port id="pr_8cf2d23f-fdeb-4bc9-b263-2868f1edaf1f_p1" x="17137.0" y="928.03973"/> <port id="pr_8cf2d23f-fdeb-4bc9-b263-2868f1edaf1f_p2" x="17107.0" y="928.03973"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ba96da80-510e-4cb8-8156-16e8504ea82a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19171760 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15541.378" y="1339.5"/> <port id="pr_ba96da80-510e-4cb8-8156-16e8504ea82a_p1" x="15546.378" y="1329.5"/> <port id="pr_ba96da80-510e-4cb8-8156-16e8504ea82a_p2" x="15546.378" y="1359.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_676b23f0-2437-4cc8-b88d-cd12b6d1eaa1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19171760 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15796.5" y="1495.75"/> <port id="pr_676b23f0-2437-4cc8-b88d-cd12b6d1eaa1_p1" x="15786.5" y="1500.75"/> <port id="pr_676b23f0-2437-4cc8-b88d-cd12b6d1eaa1_p2" x="15816.5" y="1500.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_61ba244c-96cf-4fc2-aaf5-494edf0f84ae"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Integrin alphaIII beta1 can activate Src PMID:22203675 Other integrin family member activates as well Src PMID:19734908 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="16079.0" y="1733.0"/> <port id="pr_61ba244c-96cf-4fc2-aaf5-494edf0f84ae_p1" x="16069.0" y="1738.0"/> <port id="pr_61ba244c-96cf-4fc2-aaf5-494edf0f84ae_p2" x="16099.0" y="1738.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_174f3144-cd33-4872-8fb1-3bb14dbaa163"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22203675 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15769.0" y="1346.933"/> <port id="pr_174f3144-cd33-4872-8fb1-3bb14dbaa163_p1" x="15774.0" y="1336.933"/> <port id="pr_174f3144-cd33-4872-8fb1-3bb14dbaa163_p2" x="15774.0" y="1366.933"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c405c812-3eb4-4ce0-93ff-a11627180eae"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Degradation by GSK3/AXIN (destruction complex) is the same as for the canonical-isoform of beta-catenin (no PTM) PMID:22203675 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15880.5" y="1816.75"/> <port id="pr_c405c812-3eb4-4ce0-93ff-a11627180eae_p1" x="15870.5" y="1821.75"/> <port id="pr_c405c812-3eb4-4ce0-93ff-a11627180eae_p2" x="15900.5" y="1821.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_0d4d8857-3504-4456-826c-71d4d9c48cdb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Src phosphorylates Y654 residue on b-catenin PMID:16099633 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="16219.5" y="1486.5"/> <port id="pr_0d4d8857-3504-4456-826c-71d4d9c48cdb_p1" x="16209.5" y="1491.5"/> <port id="pr_0d4d8857-3504-4456-826c-71d4d9c48cdb_p2" x="16239.5" y="1491.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5cd10411-0076-4bf6-967b-5da2bd4f97fa"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22203675 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="16486.0" y="1485.5741"/> <port id="pr_5cd10411-0076-4bf6-967b-5da2bd4f97fa_p1" x="16476.0" y="1490.5741"/> <port id="pr_5cd10411-0076-4bf6-967b-5da2bd4f97fa_p2" x="16506.0" y="1490.5741"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9b2a6463-d5eb-4e91-a52a-a093b52d2be0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19104148 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="16106.5" y="1885.0"/> <port id="pr_9b2a6463-d5eb-4e91-a52a-a093b52d2be0_p1" x="16096.5" y="1890.0"/> <port id="pr_9b2a6463-d5eb-4e91-a52a-a093b52d2be0_p2" x="16126.5" y="1890.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_a2e06142-216a-4fa0-9525-f8ad0149b9bd"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: part of canonical TGF pathway References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15780.5" y="1825.5"/> <port id="pr_a2e06142-216a-4fa0-9525-f8ad0149b9bd_p1" x="15770.5" y="1830.5"/> <port id="pr_a2e06142-216a-4fa0-9525-f8ad0149b9bd_p2" x="15800.5" y="1830.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_71ad9266-e1b4-41b8-b199-650b202590d3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22659456 PMID:22007144 PMID:19171760 PMID:10931041 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15537.584" y="1065.0"/> <port id="pr_71ad9266-e1b4-41b8-b199-650b202590d3_p1" x="15542.584" y="1055.0"/> <port id="pr_71ad9266-e1b4-41b8-b199-650b202590d3_p2" x="15542.584" y="1085.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_77635fd7-d7f8-4501-b03c-d42c6494ec5b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21152425 PMID:19244247 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15704.0" y="934.86597"/> <port id="pr_77635fd7-d7f8-4501-b03c-d42c6494ec5b_p1" x="15724.0" y="939.86597"/> <port id="pr_77635fd7-d7f8-4501-b03c-d42c6494ec5b_p2" x="15694.0" y="939.86597"/> </glyph> <glyph class="process" orientation="vertical" id="pr_fcafc466-6ab2-4d88-b262-bf8884fff44e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19244247 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15856.0" y="1075.0"/> <port id="pr_fcafc466-6ab2-4d88-b262-bf8884fff44e_p1" x="15861.0" y="1095.0"/> <port id="pr_fcafc466-6ab2-4d88-b262-bf8884fff44e_p2" x="15861.0" y="1065.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_e84028fd-c198-4f9f-af88-c98b2cec2c50"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:10671551 PMID:10837139 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15742.0" y="1330.0"/> <port id="pr_e84028fd-c198-4f9f-af88-c98b2cec2c50_p1" x="15747.0" y="1350.0"/> <port id="pr_e84028fd-c198-4f9f-af88-c98b2cec2c50_p2" x="15747.0" y="1320.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a64fb212-a590-493a-8930-aed880119a00"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:10671551 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15742.0" y="1244.0"/> <port id="pr_a64fb212-a590-493a-8930-aed880119a00_p1" x="15747.0" y="1264.0"/> <port id="pr_a64fb212-a590-493a-8930-aed880119a00_p2" x="15747.0" y="1234.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1bb020cf-309d-41bf-8090-3ef6592cdb31"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21536646 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15527.0" y="2015.5"/> <port id="pr_1bb020cf-309d-41bf-8090-3ef6592cdb31_p1" x="15532.0" y="2005.5"/> <port id="pr_1bb020cf-309d-41bf-8090-3ef6592cdb31_p2" x="15532.0" y="2035.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c23f2882-4c36-4920-a10e-70f731615c49"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15527.0" y="2336.5"/> <port id="pr_c23f2882-4c36-4920-a10e-70f731615c49_p1" x="15532.0" y="2326.5"/> <port id="pr_c23f2882-4c36-4920-a10e-70f731615c49_p2" x="15532.0" y="2356.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5ef9c70c-ca5f-43a5-8097-0748607030e6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: This complex is able to activate target genes of the canonical wnt pathway PMID:21536646 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="16063.247" y="1741.5"/> <port id="pr_5ef9c70c-ca5f-43a5-8097-0748607030e6_p1" x="16068.247" y="1761.5"/> <port id="pr_5ef9c70c-ca5f-43a5-8097-0748607030e6_p2" x="16068.247" y="1731.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_4c8d4fbe-990a-4873-8d34-cebea16e7cbb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: DVL and RIPK4 form constitutively a complex PMID:23371553 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="17302.5" y="1498.0"/> <port id="pr_4c8d4fbe-990a-4873-8d34-cebea16e7cbb_p1" x="17292.5" y="1503.0"/> <port id="pr_4c8d4fbe-990a-4873-8d34-cebea16e7cbb_p2" x="17322.5" y="1503.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_44d3ae61-d93a-40bc-a2af-91f3ebc8792d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:23371553 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="17450.0" y="1498.5"/> <port id="pr_44d3ae61-d93a-40bc-a2af-91f3ebc8792d_p1" x="17440.0" y="1503.5"/> <port id="pr_44d3ae61-d93a-40bc-a2af-91f3ebc8792d_p2" x="17470.0" y="1503.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a8ade626-40f3-43b3-b9b3-1985ef86a42c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Without RIPK4 upon wnt3 stimulation 25% of HeLa cells show DVL2 in puncta. Co-transfection of RIPK4 increases this number to more than 75% PMID:23371553 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="17657.5" y="1427.0"/> <port id="pr_a8ade626-40f3-43b3-b9b3-1985ef86a42c_p1" x="17662.5" y="1447.0"/> <port id="pr_a8ade626-40f3-43b3-b9b3-1985ef86a42c_p2" x="17662.5" y="1417.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d739d4fb-8b7e-47f6-a436-70f5a8d3b323"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: continue with dvl puncta formation References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="17102.0" y="1094.7909"/> <port id="pr_d739d4fb-8b7e-47f6-a436-70f5a8d3b323_p1" x="17122.0" y="1099.7909"/> <port id="pr_d739d4fb-8b7e-47f6-a436-70f5a8d3b323_p2" x="17092.0" y="1099.7909"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_286cb0f3-3fc6-4678-b3c2-0a48560a75ec"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22705350 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15934.5" y="1043.933"/> <port id="pr_286cb0f3-3fc6-4678-b3c2-0a48560a75ec_p1" x="15924.5" y="1048.933"/> <port id="pr_286cb0f3-3fc6-4678-b3c2-0a48560a75ec_p2" x="15954.5" y="1048.933"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_bdd7dd16-e73d-4cf4-99c3-8f750a2a7b86"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: HECTD1 KO disrupts APC-AXIN interaction and augments WNT3a-induced signaling PMID:23277359 PMID:22761442 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="16229.5" y="1270.5"/> <port id="pr_bdd7dd16-e73d-4cf4-99c3-8f750a2a7b86_p1" x="16219.5" y="1275.5"/> <port id="pr_bdd7dd16-e73d-4cf4-99c3-8f750a2a7b86_p2" x="16249.5" y="1275.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c8486698-5109-4fed-ad6b-a69e40e8aff2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Ubiquitination increases binding of APC with AXIN. PMID:23277359 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="16429.84" y="1196.625"/> <port id="pr_c8486698-5109-4fed-ad6b-a69e40e8aff2_p1" x="16434.84" y="1216.625"/> <port id="pr_c8486698-5109-4fed-ad6b-a69e40e8aff2_p2" x="16434.84" y="1186.625"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1a8bd154-d98e-42a8-9051-5082a4f163b4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22370635 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15715.958" y="2603.25"/> <port id="pr_1a8bd154-d98e-42a8-9051-5082a4f163b4_p1" x="15720.958" y="2623.25"/> <port id="pr_1a8bd154-d98e-42a8-9051-5082a4f163b4_p2" x="15720.958" y="2593.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_d46b4dc1-2700-4b77-9b9c-410d2969ddfb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22370635 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15873.0" y="2365.75"/> <port id="pr_d46b4dc1-2700-4b77-9b9c-410d2969ddfb_p1" x="15878.0" y="2385.75"/> <port id="pr_d46b4dc1-2700-4b77-9b9c-410d2969ddfb_p2" x="15878.0" y="2355.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1d187c47-7905-4f7c-b144-cc40fa25d62c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22370635 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15873.5" y="2101.5"/> <port id="pr_1d187c47-7905-4f7c-b144-cc40fa25d62c_p1" x="15878.5" y="2121.5"/> <port id="pr_1d187c47-7905-4f7c-b144-cc40fa25d62c_p2" x="15878.5" y="2091.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a107e8c6-7ab0-4496-86d4-2d9aec989c28"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:23022962 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="17564.0" y="1612.0"/> <port id="pr_a107e8c6-7ab0-4496-86d4-2d9aec989c28_p1" x="17554.0" y="1617.0"/> <port id="pr_a107e8c6-7ab0-4496-86d4-2d9aec989c28_p2" x="17584.0" y="1617.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_585b60c2-d734-4c37-a34d-c35fc4e7432a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Upon WNT3a CRIPTO-1 binds to LRP5/6 this binding is competing with DKK binding PMID:23022962 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="17542.5" y="1674.5"/> <port id="pr_585b60c2-d734-4c37-a34d-c35fc4e7432a_p1" x="17547.5" y="1664.5"/> <port id="pr_585b60c2-d734-4c37-a34d-c35fc4e7432a_p2" x="17547.5" y="1694.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ac06cfa1-1a43-4a2e-b780-8954ad0b9e3b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="16656.25" y="1483.469"/> <port id="pr_ac06cfa1-1a43-4a2e-b780-8954ad0b9e3b_p1" x="16676.25" y="1488.469"/> <port id="pr_ac06cfa1-1a43-4a2e-b780-8954ad0b9e3b_p2" x="16646.25" y="1488.469"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ba99c462-2e56-4aa5-98dc-dfe37661cfa9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="17683.0" y="1979.0"/> <port id="pr_ba99c462-2e56-4aa5-98dc-dfe37661cfa9_p1" x="17688.0" y="1969.0"/> <port id="pr_ba99c462-2e56-4aa5-98dc-dfe37661cfa9_p2" x="17688.0" y="1999.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8414d632-d39e-4c8d-8572-015bb4137476"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="17618.0" y="2027.5"/> <port id="pr_8414d632-d39e-4c8d-8572-015bb4137476_p1" x="17638.0" y="2032.5"/> <port id="pr_8414d632-d39e-4c8d-8572-015bb4137476_p2" x="17608.0" y="2032.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_1014e72d-b120-475f-a138-8170f64923b4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="17476.0" y="2028.0"/> <port id="pr_1014e72d-b120-475f-a138-8170f64923b4_p1" x="17496.0" y="2033.0"/> <port id="pr_1014e72d-b120-475f-a138-8170f64923b4_p2" x="17466.0" y="2033.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_3ca4e06a-76b7-4550-978b-00e745a924aa"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="17541.0" y="1964.5"/> <port id="pr_3ca4e06a-76b7-4550-978b-00e745a924aa_p1" x="17531.0" y="1969.5"/> <port id="pr_3ca4e06a-76b7-4550-978b-00e745a924aa_p2" x="17561.0" y="1969.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b0e20ecf-83ee-4629-8b39-dee8057c7a5a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20606702 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="17554.674" y="2096.5"/> <port id="pr_b0e20ecf-83ee-4629-8b39-dee8057c7a5a_p1" x="17559.674" y="2086.5"/> <port id="pr_b0e20ecf-83ee-4629-8b39-dee8057c7a5a_p2" x="17559.674" y="2116.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_cc67526a-bb5c-4f40-8d2b-81fc44700324"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18936100 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13639.5" y="3601.5"/> <port id="pr_cc67526a-bb5c-4f40-8d2b-81fc44700324_p1" x="13644.5" y="3591.5"/> <port id="pr_cc67526a-bb5c-4f40-8d2b-81fc44700324_p2" x="13644.5" y="3621.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_07f31a1d-98b9-4200-87ea-ea5e1cb1b91c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18936100 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13679.5" y="3601.5"/> <port id="pr_07f31a1d-98b9-4200-87ea-ea5e1cb1b91c_p1" x="13684.5" y="3621.5"/> <port id="pr_07f31a1d-98b9-4200-87ea-ea5e1cb1b91c_p2" x="13684.5" y="3591.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_0ef7eb0a-bc85-47d0-84b9-007da4a66f57"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Upon wnt signalling beta-catenin is not degraded and can enter the nucleus BCL9 and PYGO stimulate translocation of b-catenin. PMID:15208637 No active transport of b-catenin localisation of b-catenin by retention of the binding partners PMID:16554443 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13934.125" y="3579.0"/> <port id="pr_0ef7eb0a-bc85-47d0-84b9-007da4a66f57_p1" x="13939.125" y="3569.0"/> <port id="pr_0ef7eb0a-bc85-47d0-84b9-007da4a66f57_p2" x="13939.125" y="3599.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_955da436-4b9b-48c3-90a9-d96a6b6d9f83"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15208637 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13751.0" y="3599.0"/> <port id="pr_955da436-4b9b-48c3-90a9-d96a6b6d9f83_p1" x="13756.0" y="3589.0"/> <port id="pr_955da436-4b9b-48c3-90a9-d96a6b6d9f83_p2" x="13756.0" y="3619.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_00778628-edca-4d4f-815b-662104a7ba8e"> <bbox w="10.0" h="10.0" x="14213.715" y="3785.8848"/> <port id="pr_00778628-edca-4d4f-815b-662104a7ba8e_p1" x="14203.715" y="3790.8848"/> <port id="pr_00778628-edca-4d4f-815b-662104a7ba8e_p2" x="14233.715" y="3790.8848"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_01307c54-d634-4c00-bbd0-7f72914e500e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16169192 B-catenin competes with TLE for Lef-1 PMID:15768032 CBP-and P300-mediated transcription different cell fates PMID:20530697 (phosphorylated) C-JUN can bind to TCF4 PMID:18347071 PMID:16007074 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14140.469" y="4454.875"/> <port id="pr_01307c54-d634-4c00-bbd0-7f72914e500e_p1" x="14160.469" y="4459.875"/> <port id="pr_01307c54-d634-4c00-bbd0-7f72914e500e_p2" x="14130.469" y="4459.875"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_219bb787-8e5d-4f7c-98bd-07c5a7261c25"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: The transcription complex containing P300 initiates transcription of genes that are involved in differentiation. PMID:20920541 The repressor complex is is by default present on the enhancers of wnt-target genes PMID:16510874 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14258.5" y="4561.922"/> <port id="pr_219bb787-8e5d-4f7c-98bd-07c5a7261c25_p1" x="14248.5" y="4566.922"/> <port id="pr_219bb787-8e5d-4f7c-98bd-07c5a7261c25_p2" x="14278.5" y="4566.922"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a6c63204-1637-44e1-996d-088e7575a883"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: MEK/ERK cascade activation is the upstream signal required for phosphorylation. PMID:21751375 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14943.75" y="3671.0"/> <port id="pr_a6c63204-1637-44e1-996d-088e7575a883_p1" x="14963.75" y="3676.0"/> <port id="pr_a6c63204-1637-44e1-996d-088e7575a883_p2" x="14933.75" y="3676.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5765f480-91ba-41ee-bdde-8daf4c0d0e3f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: P300 acetylates beta-catenin PMID:15060161 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13555.42" y="3774.5"/> <port id="pr_5765f480-91ba-41ee-bdde-8daf4c0d0e3f_p1" x="13560.42" y="3764.5"/> <port id="pr_5765f480-91ba-41ee-bdde-8daf4c0d0e3f_p2" x="13560.42" y="3794.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2470ebb0-d90c-4dec-bfaa-8d8423e1ad9f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: CBP acetylates beta-catenin PMID:11973335 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14896.92" y="3763.318"/> <port id="pr_2470ebb0-d90c-4dec-bfaa-8d8423e1ad9f_p1" x="14886.92" y="3768.318"/> <port id="pr_2470ebb0-d90c-4dec-bfaa-8d8423e1ad9f_p2" x="14916.92" y="3768.318"/> </glyph> <glyph class="process" orientation="vertical" id="pr_e2ff787a-d263-40c3-8550-2a63446169ac"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: CBP-and P300-mediated transcription different cell fates PMID:20530697 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14229.906" y="4603.125"/> <port id="pr_e2ff787a-d263-40c3-8550-2a63446169ac_p1" x="14234.906" y="4593.125"/> <port id="pr_e2ff787a-d263-40c3-8550-2a63446169ac_p2" x="14234.906" y="4623.125"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9b82b950-a463-49c5-b6bd-4c4eba5610dd"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Acetylation of beta-catenin increases its stability PMID:18987336 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14086.6875" y="3671.5"/> <port id="pr_9b82b950-a463-49c5-b6bd-4c4eba5610dd_p1" x="14076.6875" y="3676.5"/> <port id="pr_9b82b950-a463-49c5-b6bd-4c4eba5610dd_p2" x="14106.6875" y="3676.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_048190c0-e39b-4a47-b8b0-1e65216e5541"> <bbox w="10.0" h="10.0" x="14466.25" y="4795.0"/> <port id="pr_048190c0-e39b-4a47-b8b0-1e65216e5541_p1" x="14486.25" y="4800.0"/> <port id="pr_048190c0-e39b-4a47-b8b0-1e65216e5541_p2" x="14456.25" y="4800.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_ca18e887-f1c1-4d82-8223-298a1e897638"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: The exact mechanism is depicted in the cytoplasmic fraction. Although the articles do not mention where exactly the reactions occurs TNKS are found in the cytoplasm and in the nucleus. PMID:17825467 PMID:19759537 PMID:21799911 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14466.25" y="4775.0"/> <port id="pr_ca18e887-f1c1-4d82-8223-298a1e897638_p1" x="14456.25" y="4780.0"/> <port id="pr_ca18e887-f1c1-4d82-8223-298a1e897638_p2" x="14486.25" y="4780.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ae61565d-f3a8-4daa-ad7a-9d0a1c8b40f3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16491118 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13248.5" y="5225.0"/> <port id="pr_ae61565d-f3a8-4daa-ad7a-9d0a1c8b40f3_p1" x="13238.5" y="5230.0"/> <port id="pr_ae61565d-f3a8-4daa-ad7a-9d0a1c8b40f3_p2" x="13268.5" y="5230.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f93015ee-f81e-4eba-96cb-83244c8a549c"> <bbox w="10.0" h="10.0" x="13275.5" y="3275.0"/> <port id="pr_f93015ee-f81e-4eba-96cb-83244c8a549c_p1" x="13265.5" y="3280.0"/> <port id="pr_f93015ee-f81e-4eba-96cb-83244c8a549c_p2" x="13295.5" y="3280.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_043b5a24-d0ad-4ca2-95f3-66ba4b35c857"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20194509 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13813.0625" y="3923.5"/> <port id="pr_043b5a24-d0ad-4ca2-95f3-66ba4b35c857_p1" x="13818.0625" y="3913.5"/> <port id="pr_043b5a24-d0ad-4ca2-95f3-66ba4b35c857_p2" x="13818.0625" y="3943.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c7b788b5-e136-40ee-b417-867e6d827042"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:14960582 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13977.209" y="4156.5"/> <port id="pr_c7b788b5-e136-40ee-b417-867e6d827042_p1" x="13997.209" y="4161.5"/> <port id="pr_c7b788b5-e136-40ee-b417-867e6d827042_p2" x="13967.209" y="4161.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_1eb3f718-9f4d-409b-8124-76d85422e9a8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:21118996 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13982.0" y="3382.732"/> <port id="pr_1eb3f718-9f4d-409b-8124-76d85422e9a8_p1" x="14002.0" y="3387.732"/> <port id="pr_1eb3f718-9f4d-409b-8124-76d85422e9a8_p2" x="13972.0" y="3387.732"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_4b942c5d-a6a2-4eaf-899b-2acaebaac16d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:21118996 PMID:15082531 Auto-phosphorylation HIPK2 may induce autophoshorylationMaps_Modules_end References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13855.0" y="3384.232"/> <port id="pr_4b942c5d-a6a2-4eaf-899b-2acaebaac16d_p1" x="13875.0" y="3389.232"/> <port id="pr_4b942c5d-a6a2-4eaf-899b-2acaebaac16d_p2" x="13845.0" y="3389.232"/> </glyph> <glyph class="process" orientation="vertical" id="pr_72b4dc66-2696-47ab-ab2b-e5d1d9956d14"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:21118996 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13797.625" y="3575.2632"/> <port id="pr_72b4dc66-2696-47ab-ab2b-e5d1d9956d14_p1" x="13802.625" y="3565.2632"/> <port id="pr_72b4dc66-2696-47ab-ab2b-e5d1d9956d14_p2" x="13802.625" y="3595.2632"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ae2c242f-2da6-4b78-a59f-a2ada73a9c94"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20538596 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13514.0" y="3459.3618"/> <port id="pr_ae2c242f-2da6-4b78-a59f-a2ada73a9c94_p1" x="13534.0" y="3464.3618"/> <port id="pr_ae2c242f-2da6-4b78-a59f-a2ada73a9c94_p2" x="13504.0" y="3464.3618"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_64a568a5-0810-4fac-bfc3-3b12456b4e1d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Autophosphorylation sequential order: S192 T178 T187 T184 PMID:20538596 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13367.0" y="3472.25"/> <port id="pr_64a568a5-0810-4fac-bfc3-3b12456b4e1d_p1" x="13387.0" y="3477.25"/> <port id="pr_64a568a5-0810-4fac-bfc3-3b12456b4e1d_p2" x="13357.0" y="3477.25"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_860ee03f-ecb3-4e4f-b329-8f7e3326c45e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16714285 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13838.625" y="4156.5"/> <port id="pr_860ee03f-ecb3-4e4f-b329-8f7e3326c45e_p1" x="13858.625" y="4161.5"/> <port id="pr_860ee03f-ecb3-4e4f-b329-8f7e3326c45e_p2" x="13828.625" y="4161.5"/> </glyph> <glyph class="omitted process" orientation="vertical" id="pr_f1c07362-77d4-4ec4-b3e8-c833fa69b7e3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16714285 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13775.3545" y="4107.25"/> <port id="pr_f1c07362-77d4-4ec4-b3e8-c833fa69b7e3_p1" x="13780.3545" y="4127.25"/> <port id="pr_f1c07362-77d4-4ec4-b3e8-c833fa69b7e3_p2" x="13780.3545" y="4097.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_7718752b-9a45-427a-aa34-9cee41122e52"> <bbox w="10.0" h="10.0" x="14306.203" y="4241.048"/> <port id="pr_7718752b-9a45-427a-aa34-9cee41122e52_p1" x="14296.203" y="4246.048"/> <port id="pr_7718752b-9a45-427a-aa34-9cee41122e52_p2" x="14326.203" y="4246.048"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a3b3195c-d400-4e6a-9114-c038d93fc252"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: CK2 phosphorylates TLE PMID:15367661 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14313.541" y="4156.3613"/> <port id="pr_a3b3195c-d400-4e6a-9114-c038d93fc252_p1" x="14303.541" y="4161.3613"/> <port id="pr_a3b3195c-d400-4e6a-9114-c038d93fc252_p2" x="14333.541" y="4161.3613"/> </glyph> <glyph class="process" orientation="vertical" id="pr_203746b7-22d8-4627-8134-1140b8e5141d"> <bbox w="10.0" h="10.0" x="14597.631" y="3968.0"/> <port id="pr_203746b7-22d8-4627-8134-1140b8e5141d_p1" x="14602.631" y="3988.0"/> <port id="pr_203746b7-22d8-4627-8134-1140b8e5141d_p2" x="14602.631" y="3958.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c00f5402-28fd-4b6a-8297-b86ffacdaf20"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15367661 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14437.5" y="4008.4702"/> <port id="pr_c00f5402-28fd-4b6a-8297-b86ffacdaf20_p1" x="14427.5" y="4013.4702"/> <port id="pr_c00f5402-28fd-4b6a-8297-b86ffacdaf20_p2" x="14457.5" y="4013.4702"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6a908394-b34a-49eb-a902-2a3c2f54cc1a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18519670 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13248.5" y="5185.0"/> <port id="pr_6a908394-b34a-49eb-a902-2a3c2f54cc1a_p1" x="13238.5" y="5190.0"/> <port id="pr_6a908394-b34a-49eb-a902-2a3c2f54cc1a_p2" x="13268.5" y="5190.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_94934c41-c78b-41c5-ace9-b1262dafd82d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Its suggested that XIAP constitutively ubiquitinate TLE PMID:22304967 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14238.334" y="4220.25"/> <port id="pr_94934c41-c78b-41c5-ace9-b1262dafd82d_p1" x="14243.334" y="4210.25"/> <port id="pr_94934c41-c78b-41c5-ace9-b1262dafd82d_p2" x="14243.334" y="4240.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_32787b06-4358-4304-bd28-62e9021e1d6e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Not sure if ubiquitination by XIAP is necessary for replacement of TLE by b-catenin upon canonical WNT signaling PMID:22304967 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14365.469" y="4382.3125"/> <port id="pr_32787b06-4358-4304-bd28-62e9021e1d6e_p1" x="14385.469" y="4387.3125"/> <port id="pr_32787b06-4358-4304-bd28-62e9021e1d6e_p2" x="14355.469" y="4387.3125"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_2f0ecc5f-48c4-4a07-936a-11359edcaab0"> <bbox w="20.0" h="20.0" x="14124.933" y="4333.246"/> <port id="logicglyph_2f0ecc5f-48c4-4a07-936a-11359edcaab0_p1" x="14114.933" y="4343.246"/> <port id="logicglyph_2f0ecc5f-48c4-4a07-936a-11359edcaab0_p2" x="14154.933" y="4343.246"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_277e1574-72fb-42c7-9a1a-7757e32cab30"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22045851 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13238.0" y="4776.0"/> <port id="pr_277e1574-72fb-42c7-9a1a-7757e32cab30_p1" x="13228.0" y="4781.0"/> <port id="pr_277e1574-72fb-42c7-9a1a-7757e32cab30_p2" x="13258.0" y="4781.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_b657dc65-fbaa-491b-829f-60e1eed514ec"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22045851 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13238.0" y="4809.642"/> <port id="pr_b657dc65-fbaa-491b-829f-60e1eed514ec_p1" x="13228.0" y="4814.642"/> <port id="pr_b657dc65-fbaa-491b-829f-60e1eed514ec_p2" x="13258.0" y="4814.642"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_3c14cd2f-d5d1-4a88-b82b-31972276061b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22045851 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13240.25" y="4843.2764"/> <port id="pr_3c14cd2f-d5d1-4a88-b82b-31972276061b_p1" x="13230.25" y="4848.2764"/> <port id="pr_3c14cd2f-d5d1-4a88-b82b-31972276061b_p2" x="13260.25" y="4848.2764"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_89dc7727-ae3b-476e-90c0-bb814ea3b060"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Mi-2/NuRD PMID:22290435 SWI/SNF References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13240.25" y="4877.1426"/> <port id="pr_89dc7727-ae3b-476e-90c0-bb814ea3b060_p1" x="13230.25" y="4882.1426"/> <port id="pr_89dc7727-ae3b-476e-90c0-bb814ea3b060_p2" x="13260.25" y="4882.1426"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_654996f9-76a3-45a3-b7ae-914a0b181510"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20710043 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13240.25" y="4910.8574"/> <port id="pr_654996f9-76a3-45a3-b7ae-914a0b181510_p1" x="13230.25" y="4915.8574"/> <port id="pr_654996f9-76a3-45a3-b7ae-914a0b181510_p2" x="13260.25" y="4915.8574"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_be06013c-b7b0-4227-914c-9ec6e7e591b0"> <bbox w="10.0" h="10.0" x="13240.25" y="4944.5713"/> <port id="pr_be06013c-b7b0-4227-914c-9ec6e7e591b0_p1" x="13230.25" y="4949.5713"/> <port id="pr_be06013c-b7b0-4227-914c-9ec6e7e591b0_p2" x="13260.25" y="4949.5713"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_bc81ae53-0798-415e-af19-3d0c2b73f15d"> <bbox w="10.0" h="10.0" x="13240.25" y="4978.2856"/> <port id="pr_bc81ae53-0798-415e-af19-3d0c2b73f15d_p1" x="13230.25" y="4983.2856"/> <port id="pr_bc81ae53-0798-415e-af19-3d0c2b73f15d_p2" x="13260.25" y="4983.2856"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d13280d9-b142-42ba-b620-313d2d51a186"> <bbox w="10.0" h="10.0" x="13240.25" y="5012.0"/> <port id="pr_d13280d9-b142-42ba-b620-313d2d51a186_p1" x="13230.25" y="5017.0"/> <port id="pr_d13280d9-b142-42ba-b620-313d2d51a186_p2" x="13260.25" y="5017.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_800ceaca-7667-4011-b096-ece849ac9101"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22045851 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13368.94" y="4745.25"/> <port id="pr_800ceaca-7667-4011-b096-ece849ac9101_p1" x="13373.94" y="4765.25"/> <port id="pr_800ceaca-7667-4011-b096-ece849ac9101_p2" x="13373.94" y="4735.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_95d82af5-08df-4e05-b145-979a842bc38a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22045851 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13368.682" y="4762.25"/> <port id="pr_95d82af5-08df-4e05-b145-979a842bc38a_p1" x="13373.682" y="4782.25"/> <port id="pr_95d82af5-08df-4e05-b145-979a842bc38a_p2" x="13373.682" y="4752.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_6b61a04b-4d56-46f4-b5c5-c43ac2caa6ff"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22045851 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13368.783" y="4784.25"/> <port id="pr_6b61a04b-4d56-46f4-b5c5-c43ac2caa6ff_p1" x="13373.783" y="4804.25"/> <port id="pr_6b61a04b-4d56-46f4-b5c5-c43ac2caa6ff_p2" x="13373.783" y="4774.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_663779fe-f2e8-4e13-b506-747159456abd"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22045851 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13428.5" y="4746.4814"/> <port id="pr_663779fe-f2e8-4e13-b506-747159456abd_p1" x="13418.5" y="4751.4814"/> <port id="pr_663779fe-f2e8-4e13-b506-747159456abd_p2" x="13448.5" y="4751.4814"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5671497e-9189-44b4-afab-7ef7e7af2d86"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22045851 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13428.5" y="4763.0186"/> <port id="pr_5671497e-9189-44b4-afab-7ef7e7af2d86_p1" x="13418.5" y="4768.0186"/> <port id="pr_5671497e-9189-44b4-afab-7ef7e7af2d86_p2" x="13448.5" y="4768.0186"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c5ba55df-a604-4fcd-a058-c653db033ee7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22045851 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13429.5" y="4779.047"/> <port id="pr_c5ba55df-a604-4fcd-a058-c653db033ee7_p1" x="13419.5" y="4784.047"/> <port id="pr_c5ba55df-a604-4fcd-a058-c653db033ee7_p2" x="13449.5" y="4784.047"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_1109e70e-223a-4c4e-9c40-b7a917793aae"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22045851 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13461.25" y="4859.0503"/> <port id="pr_1109e70e-223a-4c4e-9c40-b7a917793aae_p1" x="13451.25" y="4864.0503"/> <port id="pr_1109e70e-223a-4c4e-9c40-b7a917793aae_p2" x="13481.25" y="4864.0503"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_3c25bff3-e37a-4229-a5ab-31f8f12877ee"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22045851 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13461.25" y="4859.0503"/> <port id="pr_3c25bff3-e37a-4229-a5ab-31f8f12877ee_p1" x="13451.25" y="4864.0503"/> <port id="pr_3c25bff3-e37a-4229-a5ab-31f8f12877ee_p2" x="13481.25" y="4864.0503"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_35d3e7f7-7c6d-4e2b-96a7-b7ea82590e43"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22045851 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13440.25" y="4859.033"/> <port id="pr_35d3e7f7-7c6d-4e2b-96a7-b7ea82590e43_p1" x="13430.25" y="4864.033"/> <port id="pr_35d3e7f7-7c6d-4e2b-96a7-b7ea82590e43_p2" x="13460.25" y="4864.033"/> </glyph> <glyph class="process" orientation="vertical" id="pr_0f256917-0a63-48e7-bf27-b4b431fee32b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22045851 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13372.992" y="4987.25"/> <port id="pr_0f256917-0a63-48e7-bf27-b4b431fee32b_p1" x="13377.992" y="4977.25"/> <port id="pr_0f256917-0a63-48e7-bf27-b4b431fee32b_p2" x="13377.992" y="5007.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_cbc333fd-1209-46a1-b348-f70634d3a15e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22045851 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13372.25" y="4987.25"/> <port id="pr_cbc333fd-1209-46a1-b348-f70634d3a15e_p1" x="13377.25" y="4977.25"/> <port id="pr_cbc333fd-1209-46a1-b348-f70634d3a15e_p2" x="13377.25" y="5007.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_bb782d5b-58d5-4ae0-9ed4-3bbe97aa9606"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22045851 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13372.25" y="4987.25"/> <port id="pr_bb782d5b-58d5-4ae0-9ed4-3bbe97aa9606_p1" x="13377.25" y="4977.25"/> <port id="pr_bb782d5b-58d5-4ae0-9ed4-3bbe97aa9606_p2" x="13377.25" y="5007.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ac2d9d1d-aff7-4c07-9e1e-847f25cb148f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22045851 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13370.25" y="4858.0"/> <port id="pr_ac2d9d1d-aff7-4c07-9e1e-847f25cb148f_p1" x="13360.25" y="4863.0"/> <port id="pr_ac2d9d1d-aff7-4c07-9e1e-847f25cb148f_p2" x="13390.25" y="4863.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_111deaf0-2dfe-4cb6-814a-eac46e8b16f4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22045851 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13370.25" y="4858.0"/> <port id="pr_111deaf0-2dfe-4cb6-814a-eac46e8b16f4_p1" x="13360.25" y="4863.0"/> <port id="pr_111deaf0-2dfe-4cb6-814a-eac46e8b16f4_p2" x="13390.25" y="4863.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_0ea61d60-9802-40e7-9f93-49934ad1b7fc"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:22045851 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13370.5" y="4858.0"/> <port id="pr_0ea61d60-9802-40e7-9f93-49934ad1b7fc_p1" x="13360.5" y="4863.0"/> <port id="pr_0ea61d60-9802-40e7-9f93-49934ad1b7fc_p2" x="13390.5" y="4863.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_e42ab99b-810a-4f78-8d14-fb0b713d74d7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Under pathological conditions this complex will be formed. This complex has synergistic positive effect on myc gene expression. PMID:15576399 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14746.279" y="4010.5"/> <port id="pr_e42ab99b-810a-4f78-8d14-fb0b713d74d7_p1" x="14751.279" y="4000.5"/> <port id="pr_e42ab99b-810a-4f78-8d14-fb0b713d74d7_p2" x="14751.279" y="4030.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_bdd7f8b7-6e70-456c-8157-5d4bd140b9f6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22761862 Smad1 alone inhibits myc expression while b-catenin/TCF4 activates gene expression. Highest gene expression obtained when SMAD1/b-catenin/TCF4 complex is formed PMID:15576399 Mi-2/NuRD PMID:22290435 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14840.5" y="4404.0"/> <port id="pr_bdd7f8b7-6e70-456c-8157-5d4bd140b9f6_p1" x="14830.5" y="4409.0"/> <port id="pr_bdd7f8b7-6e70-456c-8157-5d4bd140b9f6_p2" x="14860.5" y="4409.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c7abb1f4-b911-4ec5-98fb-51a43901919a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19000719 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14416.5" y="3683.0"/> <port id="pr_c7abb1f4-b911-4ec5-98fb-51a43901919a_p1" x="14406.5" y="3688.0"/> <port id="pr_c7abb1f4-b911-4ec5-98fb-51a43901919a_p2" x="14436.5" y="3688.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_904cdde7-e5ad-4227-be8d-c4252efcfab0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Synergistic effect on HES1 transcription PMID:19000719 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14383.0" y="3762.5"/> <port id="pr_904cdde7-e5ad-4227-be8d-c4252efcfab0_p1" x="14373.0" y="3767.5"/> <port id="pr_904cdde7-e5ad-4227-be8d-c4252efcfab0_p2" x="14403.0" y="3767.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_34c9fce3-f35f-4eec-a1f4-2a8620c32d82"> <bbox w="10.0" h="10.0" x="14420.375" y="3851.5"/> <port id="pr_34c9fce3-f35f-4eec-a1f4-2a8620c32d82_p1" x="14425.375" y="3841.5"/> <port id="pr_34c9fce3-f35f-4eec-a1f4-2a8620c32d82_p2" x="14425.375" y="3871.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_05eceebf-be10-48d1-9fee-19f4e0ae3a89"> <bbox w="10.0" h="10.0" x="14667.0" y="3815.0"/> <port id="pr_05eceebf-be10-48d1-9fee-19f4e0ae3a89_p1" x="14657.0" y="3820.0"/> <port id="pr_05eceebf-be10-48d1-9fee-19f4e0ae3a89_p2" x="14687.0" y="3820.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f43d2d93-d481-4549-b55f-1c7b66314afa"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19383900 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14801.75" y="3782.187"/> <port id="pr_f43d2d93-d481-4549-b55f-1c7b66314afa_p1" x="14791.75" y="3787.187"/> <port id="pr_f43d2d93-d481-4549-b55f-1c7b66314afa_p2" x="14821.75" y="3787.187"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ac320066-5ea2-4b3e-aa2f-e8b530a60497"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:11972058 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="12923.976" y="3546.5625"/> <port id="pr_ac320066-5ea2-4b3e-aa2f-e8b530a60497_p1" x="12928.976" y="3566.5625"/> <port id="pr_ac320066-5ea2-4b3e-aa2f-e8b530a60497_p2" x="12928.976" y="3536.5625"/> </glyph> <glyph class="process" orientation="vertical" id="pr_937ca5a6-ce27-4d35-bcae-c385cddc0bea"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Site is adjacent to the NLS2 in APC PMID:11689703 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="12929.0" y="3708.5"/> <port id="pr_937ca5a6-ce27-4d35-bcae-c385cddc0bea_p1" x="12934.0" y="3698.5"/> <port id="pr_937ca5a6-ce27-4d35-bcae-c385cddc0bea_p2" x="12934.0" y="3728.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d4b14322-59f2-484b-9087-69a52035bbff"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: This transport is enhanced upon phosphorylation however it is not necessary for import of APC into nucleus PMID:11689703 PMID:15649893 PMID:11050185 PMID:12223464 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13148.0" y="3857.5"/> <port id="pr_d4b14322-59f2-484b-9087-69a52035bbff_p1" x="13138.0" y="3862.5"/> <port id="pr_d4b14322-59f2-484b-9087-69a52035bbff_p2" x="13168.0" y="3862.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1bc49d78-a396-46d5-acaf-272dce8a5414"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11689703 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="12908.875" y="3739.5"/> <port id="pr_1bc49d78-a396-46d5-acaf-272dce8a5414_p1" x="12913.875" y="3729.5"/> <port id="pr_1bc49d78-a396-46d5-acaf-272dce8a5414_p2" x="12913.875" y="3759.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_cb1bf223-0e52-4d5c-9052-b3646ef047b1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Import of APC does not require phosphorylation of APC PMID:12223464 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13167.5" y="3619.0"/> <port id="pr_cb1bf223-0e52-4d5c-9052-b3646ef047b1_p1" x="13157.5" y="3624.0"/> <port id="pr_cb1bf223-0e52-4d5c-9052-b3646ef047b1_p2" x="13187.5" y="3624.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_df9f9121-3466-484a-9db9-37da3f212fd2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:10984057 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13191.875" y="3645.5"/> <port id="pr_df9f9121-3466-484a-9db9-37da3f212fd2_p1" x="13211.875" y="3650.5"/> <port id="pr_df9f9121-3466-484a-9db9-37da3f212fd2_p2" x="13181.875" y="3650.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_75a7f7e2-e230-42e9-a521-af43eab08718"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:10984057 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13185.1875" y="3819.5"/> <port id="pr_75a7f7e2-e230-42e9-a521-af43eab08718_p1" x="13205.1875" y="3824.5"/> <port id="pr_75a7f7e2-e230-42e9-a521-af43eab08718_p2" x="13175.1875" y="3824.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a119e6c6-8d30-4117-a032-b119d0044c82"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:10980707 PMID:12606575 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13106.0" y="4089.0"/> <port id="pr_a119e6c6-8d30-4117-a032-b119d0044c82_p1" x="13126.0" y="4094.0"/> <port id="pr_a119e6c6-8d30-4117-a032-b119d0044c82_p2" x="13096.0" y="4094.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f5df4524-7003-430b-8a3a-8a1dafe8c0ef"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:10980707 PMID:12606575 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13116.0" y="4225.0"/> <port id="pr_f5df4524-7003-430b-8a3a-8a1dafe8c0ef_p1" x="13136.0" y="4230.0"/> <port id="pr_f5df4524-7003-430b-8a3a-8a1dafe8c0ef_p2" x="13106.0" y="4230.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_b735c1ed-cf6c-49bb-8378-918f3ea3f46d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:10984057 PMID:11263497 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13355.875" y="3992.0762"/> <port id="pr_b735c1ed-cf6c-49bb-8378-918f3ea3f46d_p1" x="13375.875" y="3997.0762"/> <port id="pr_b735c1ed-cf6c-49bb-8378-918f3ea3f46d_p2" x="13345.875" y="3997.0762"/> </glyph> <glyph class="process" orientation="vertical" id="pr_9cd3a5b4-46d7-49ce-a907-3bda15436484"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:10984057 PMID:11263497 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13352.709" y="4171.8926"/> <port id="pr_9cd3a5b4-46d7-49ce-a907-3bda15436484_p1" x="13357.709" y="4161.8926"/> <port id="pr_9cd3a5b4-46d7-49ce-a907-3bda15436484_p2" x="13357.709" y="4191.8926"/> </glyph> <glyph class="process" orientation="vertical" id="pr_df320ebc-7b11-4836-8174-f76592d37cd1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11585828 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13003.77" y="3659.0815"/> <port id="pr_df320ebc-7b11-4836-8174-f76592d37cd1_p1" x="13008.77" y="3679.0815"/> <port id="pr_df320ebc-7b11-4836-8174-f76592d37cd1_p2" x="13008.77" y="3649.0815"/> </glyph> <glyph class="process" orientation="vertical" id="pr_92bb8103-f736-4c5a-b6e4-747c081e87b0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:11585828 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13004.951" y="3800.5"/> <port id="pr_92bb8103-f736-4c5a-b6e4-747c081e87b0_p1" x="13009.951" y="3790.5"/> <port id="pr_92bb8103-f736-4c5a-b6e4-747c081e87b0_p2" x="13009.951" y="3820.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_834b562a-3e00-4179-99a5-41e7b5c4a71d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Not known if this dissociation occurs (here or later) References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13323.6875" y="3831.0"/> <port id="pr_834b562a-3e00-4179-99a5-41e7b5c4a71d_p1" x="13313.6875" y="3836.0"/> <port id="pr_834b562a-3e00-4179-99a5-41e7b5c4a71d_p2" x="13343.6875" y="3836.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_3f96525c-a5e5-46b3-bb15-5e4758768a76"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Not known if this dissociation occurs (here or later) References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13351.875" y="3655.0"/> <port id="pr_3f96525c-a5e5-46b3-bb15-5e4758768a76_p1" x="13341.875" y="3660.0"/> <port id="pr_3f96525c-a5e5-46b3-bb15-5e4758768a76_p2" x="13371.875" y="3660.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_bd0178a7-693e-43db-92a8-70702c81fa4b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Allosteric effect PMID:10747897 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13104.5" y="3498.5"/> <port id="pr_bd0178a7-693e-43db-92a8-70702c81fa4b_p1" x="13124.5" y="3503.5"/> <port id="pr_bd0178a7-693e-43db-92a8-70702c81fa4b_p2" x="13094.5" y="3503.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_51fff31f-7096-43d5-b81f-e810713c1022"> <bbox w="10.0" h="10.0" x="13568.984" y="3339.25"/> <port id="pr_51fff31f-7096-43d5-b81f-e810713c1022_p1" x="13573.984" y="3359.25"/> <port id="pr_51fff31f-7096-43d5-b81f-e810713c1022_p2" x="13573.984" y="3329.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_31f07733-dffe-47a1-81b0-52a86003075f"> <bbox w="10.0" h="10.0" x="13492.0" y="3671.5"/> <port id="pr_31f07733-dffe-47a1-81b0-52a86003075f_p1" x="13482.0" y="3676.5"/> <port id="pr_31f07733-dffe-47a1-81b0-52a86003075f_p2" x="13512.0" y="3676.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_76c1058d-a6bf-4293-bed0-df2e5c4e8591"> <bbox w="10.0" h="10.0" x="13013.5" y="4126.9785"/> <port id="pr_76c1058d-a6bf-4293-bed0-df2e5c4e8591_p1" x="13003.5" y="4131.9785"/> <port id="pr_76c1058d-a6bf-4293-bed0-df2e5c4e8591_p2" x="13033.5" y="4131.9785"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_83bf662e-931a-4795-9c8a-177d84ed00a0"> <bbox w="10.0" h="10.0" x="13018.969" y="4178.5"/> <port id="pr_83bf662e-931a-4795-9c8a-177d84ed00a0_p1" x="13008.969" y="4183.5"/> <port id="pr_83bf662e-931a-4795-9c8a-177d84ed00a0_p2" x="13038.969" y="4183.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_4dd47f3d-6906-44f8-80fc-d8a610e5d3c1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15747065 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14053.084" y="4097.75"/> <port id="pr_4dd47f3d-6906-44f8-80fc-d8a610e5d3c1_p1" x="14058.084" y="4117.75"/> <port id="pr_4dd47f3d-6906-44f8-80fc-d8a610e5d3c1_p2" x="14058.084" y="4087.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_1fbc37b4-b071-4f2f-adb5-6df17ec588e2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15525529 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13576.5" y="4333.831"/> <port id="pr_1fbc37b4-b071-4f2f-adb5-6df17ec588e2_p1" x="13566.5" y="4338.831"/> <port id="pr_1fbc37b4-b071-4f2f-adb5-6df17ec588e2_p2" x="13596.5" y="4338.831"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_78c53d24-2f9d-433e-86aa-667372824fd8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15037661 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13255.5" y="4326.5"/> <port id="pr_78c53d24-2f9d-433e-86aa-667372824fd8_p1" x="13245.5" y="4331.5"/> <port id="pr_78c53d24-2f9d-433e-86aa-667372824fd8_p2" x="13275.5" y="4331.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f4c90392-98ba-4f38-8694-9c2695ff940c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12681518 PMID:16510874 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13784.203" y="4331.166"/> <port id="pr_f4c90392-98ba-4f38-8694-9c2695ff940c_p1" x="13774.203" y="4336.166"/> <port id="pr_f4c90392-98ba-4f38-8694-9c2695ff940c_p2" x="13804.203" y="4336.166"/> </glyph> <glyph class="process" orientation="vertical" id="pr_913b9e2e-84fc-4d1f-9c7a-b8d1466ff73f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15327769 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13850.75" y="4440.0"/> <port id="pr_913b9e2e-84fc-4d1f-9c7a-b8d1466ff73f_p1" x="13855.75" y="4430.0"/> <port id="pr_913b9e2e-84fc-4d1f-9c7a-b8d1466ff73f_p2" x="13855.75" y="4460.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9a804ea5-9c18-497a-a056-acd9f1da92db"> <bbox w="10.0" h="10.0" x="13706.375" y="4650.008"/> <port id="pr_9a804ea5-9c18-497a-a056-acd9f1da92db_p1" x="13726.375" y="4655.008"/> <port id="pr_9a804ea5-9c18-497a-a056-acd9f1da92db_p2" x="13696.375" y="4655.008"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9c7fc6e1-f486-4ad8-90c4-d7f6f3db82e7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12711682 PMID:15834423 PMID:16510874 PMID:15327769 PMID:16547505 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13764.875" y="4918.4004"/> <port id="pr_9c7fc6e1-f486-4ad8-90c4-d7f6f3db82e7_p1" x="13754.875" y="4923.4004"/> <port id="pr_9c7fc6e1-f486-4ad8-90c4-d7f6f3db82e7_p2" x="13784.875" y="4923.4004"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f1effaa2-6aca-4542-a18f-349ec9ce5869"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:16510874 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13398.0" y="4581.5"/> <port id="pr_f1effaa2-6aca-4542-a18f-349ec9ce5869_p1" x="13418.0" y="4586.5"/> <port id="pr_f1effaa2-6aca-4542-a18f-349ec9ce5869_p2" x="13388.0" y="4586.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_3068d477-891d-46c5-9ec9-f6a16aa4a8eb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:16510874 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13931.568" y="5002.0"/> <port id="pr_3068d477-891d-46c5-9ec9-f6a16aa4a8eb_p1" x="13936.568" y="5022.0"/> <port id="pr_3068d477-891d-46c5-9ec9-f6a16aa4a8eb_p2" x="13936.568" y="4992.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a13a43d5-5dcb-4d80-bdf8-1b2f2d592e7a"> <bbox w="10.0" h="10.0" x="13028.107" y="4247.0"/> <port id="pr_a13a43d5-5dcb-4d80-bdf8-1b2f2d592e7a_p1" x="13033.107" y="4267.0"/> <port id="pr_a13a43d5-5dcb-4d80-bdf8-1b2f2d592e7a_p2" x="13033.107" y="4237.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a84100c2-3167-4b72-8fe1-b76d3d66f152"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21416054 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13493.0" y="5191.6"/> <port id="pr_a84100c2-3167-4b72-8fe1-b76d3d66f152_p1" x="13483.0" y="5196.6"/> <port id="pr_a84100c2-3167-4b72-8fe1-b76d3d66f152_p2" x="13513.0" y="5196.6"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8c33808d-d659-4b7f-8c6e-baaafd39fdbc"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: KLF8 recruits P300 PMID:22761862 PMID:20107328 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13457.482" y="4000.1646"/> <port id="pr_8c33808d-d659-4b7f-8c6e-baaafd39fdbc_p1" x="13477.482" y="4005.1646"/> <port id="pr_8c33808d-d659-4b7f-8c6e-baaafd39fdbc_p2" x="13447.482" y="4005.1646"/> </glyph> <glyph class="process" orientation="vertical" id="pr_687b570f-49fc-45a5-8caa-0e79c7820123"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21416054 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13420.9375" y="4333.5"/> <port id="pr_687b570f-49fc-45a5-8caa-0e79c7820123_p1" x="13425.9375" y="4323.5"/> <port id="pr_687b570f-49fc-45a5-8caa-0e79c7820123_p2" x="13425.9375" y="4353.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2c27c462-21ef-4762-9e6d-bba756a83ecd"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22761862 Swi/SNF complex PMID:22290435 NuRD complex: b-catenin/CTBP/Hipk2/LEF1 complex PMID:17666529 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14840.5" y="4444.5"/> <port id="pr_2c27c462-21ef-4762-9e6d-bba756a83ecd_p1" x="14830.5" y="4449.5"/> <port id="pr_2c27c462-21ef-4762-9e6d-bba756a83ecd_p2" x="14860.5" y="4449.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_60ca46c4-c95d-4600-8017-e91cddfb7b93"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22761862 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14840.5" y="4485.0"/> <port id="pr_60ca46c4-c95d-4600-8017-e91cddfb7b93_p1" x="14830.5" y="4490.0"/> <port id="pr_60ca46c4-c95d-4600-8017-e91cddfb7b93_p2" x="14860.5" y="4490.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_d9c7123f-3c1c-491d-927f-6a0b2847cba3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:10756197 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13237.162" y="4406.1562"/> <port id="pr_d9c7123f-3c1c-491d-927f-6a0b2847cba3_p1" x="13242.162" y="4396.1562"/> <port id="pr_d9c7123f-3c1c-491d-927f-6a0b2847cba3_p2" x="13242.162" y="4426.1562"/> </glyph> <glyph class="omitted process" orientation="vertical" id="pr_d8733126-47b2-4a86-b85d-662158b0900b"> <bbox w="10.0" h="10.0" x="13210.0" y="4597.0"/> <port id="pr_d8733126-47b2-4a86-b85d-662158b0900b_p1" x="13215.0" y="4587.0"/> <port id="pr_d8733126-47b2-4a86-b85d-662158b0900b_p2" x="13215.0" y="4617.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_2056537c-8401-40b9-a716-0fdcd5cd7915"> <bbox w="10.0" h="10.0" x="13790.08" y="4485.25"/> <port id="pr_2056537c-8401-40b9-a716-0fdcd5cd7915_p1" x="13795.08" y="4505.25"/> <port id="pr_2056537c-8401-40b9-a716-0fdcd5cd7915_p2" x="13795.08" y="4475.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_493d3b7d-0f15-426d-9b45-eb3db1e35fd8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:21416054 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13493.0" y="5232.6"/> <port id="pr_493d3b7d-0f15-426d-9b45-eb3db1e35fd8_p1" x="13483.0" y="5237.6"/> <port id="pr_493d3b7d-0f15-426d-9b45-eb3db1e35fd8_p2" x="13513.0" y="5237.6"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8dd00720-9dbb-4d44-a644-12e41d45bfb4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Not sure if this mechanism is exact the same as for CYCLIND Myc and AXIN1 transcription. However it has been shown that KLF8 and b-catenin induces transcription of MMP9 gene. PMID:21151179 PMID:17306568 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14841.0" y="4524.0"/> <port id="pr_8dd00720-9dbb-4d44-a644-12e41d45bfb4_p1" x="14831.0" y="4529.0"/> <port id="pr_8dd00720-9dbb-4d44-a644-12e41d45bfb4_p2" x="14861.0" y="4529.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a086f036-39c3-4a17-8dac-6974aac2f7a7"> <bbox w="10.0" h="10.0" x="13522.906" y="4520.321"/> <port id="pr_a086f036-39c3-4a17-8dac-6974aac2f7a7_p1" x="13512.906" y="4525.321"/> <port id="pr_a086f036-39c3-4a17-8dac-6974aac2f7a7_p2" x="13542.906" y="4525.321"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_fbb2d30a-fe29-47bd-ab7c-2d810e2f0adf"> <bbox w="10.0" h="10.0" x="14449.0" y="4563.371"/> <port id="pr_fbb2d30a-fe29-47bd-ab7c-2d810e2f0adf_p1" x="14439.0" y="4568.371"/> <port id="pr_fbb2d30a-fe29-47bd-ab7c-2d810e2f0adf_p2" x="14469.0" y="4568.371"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_4802b935-9c25-4ae1-b968-36ad15f6a3d5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: CBP-mediated transcription effects genes that are involved in stemm cell or progenitor cell maintenance and proliferation PMID:20920541 Repressor complex is default present on the enhance of wnt-target genes PMID:16510874 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14251.5" y="4630.25"/> <port id="pr_4802b935-9c25-4ae1-b968-36ad15f6a3d5_p1" x="14241.5" y="4635.25"/> <port id="pr_4802b935-9c25-4ae1-b968-36ad15f6a3d5_p2" x="14271.5" y="4635.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_7013f16e-f75b-4ce1-bb23-f20cf54de1a7"> <bbox w="10.0" h="10.0" x="14442.5" y="4630.25"/> <port id="pr_7013f16e-f75b-4ce1-bb23-f20cf54de1a7_p1" x="14432.5" y="4635.25"/> <port id="pr_7013f16e-f75b-4ce1-bb23-f20cf54de1a7_p2" x="14462.5" y="4635.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6b719eb7-5781-4fc5-a7fc-3f93941a8fc6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19901072 PMID:19751731 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14172.107" y="3913.608"/> <port id="pr_6b719eb7-5781-4fc5-a7fc-3f93941a8fc6_p1" x="14192.107" y="3918.608"/> <port id="pr_6b719eb7-5781-4fc5-a7fc-3f93941a8fc6_p2" x="14162.107" y="3918.608"/> </glyph> <glyph class="process" orientation="vertical" id="pr_d7d10680-f3f5-4655-828e-c14b7d0e7d9f"> <bbox w="10.0" h="10.0" x="14516.285" y="5181.0"/> <port id="pr_d7d10680-f3f5-4655-828e-c14b7d0e7d9f_p1" x="14521.285" y="5171.0"/> <port id="pr_d7d10680-f3f5-4655-828e-c14b7d0e7d9f_p2" x="14521.285" y="5201.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_78d864de-0dc8-4cb5-8149-6febd17732d9"> <bbox w="10.0" h="10.0" x="14434.149" y="5137.25"/> <port id="pr_78d864de-0dc8-4cb5-8149-6febd17732d9_p1" x="14439.149" y="5127.25"/> <port id="pr_78d864de-0dc8-4cb5-8149-6febd17732d9_p2" x="14439.149" y="5157.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_19d51851-9e3b-4922-95ed-1cadc0316dc9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Mi-2/NuRD PMID:22290435 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13240.25" y="5049.0"/> <port id="pr_19d51851-9e3b-4922-95ed-1cadc0316dc9_p1" x="13230.25" y="5054.0"/> <port id="pr_19d51851-9e3b-4922-95ed-1cadc0316dc9_p2" x="13260.25" y="5054.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8209de09-98e1-415e-95bb-0d0a9ff31c4b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Actually the whole MIR-34 family targets AXIN2 PMID:22421157 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13464.0" y="4992.0"/> <port id="pr_8209de09-98e1-415e-95bb-0d0a9ff31c4b_p1" x="13454.0" y="4997.0"/> <port id="pr_8209de09-98e1-415e-95bb-0d0a9ff31c4b_p2" x="13484.0" y="4997.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_29aa3ebe-016d-44df-8919-c71acdb77815"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: MTA1 HDAC2 were shown together with NuRD to bind to six3-promoter region. PMID:20682799 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13492.5" y="5280.0"/> <port id="pr_29aa3ebe-016d-44df-8919-c71acdb77815_p1" x="13482.5" y="5285.0"/> <port id="pr_29aa3ebe-016d-44df-8919-c71acdb77815_p2" x="13512.5" y="5285.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5406fe28-0f29-46a1-b875-2ca02a766f51"> <bbox w="10.0" h="10.0" x="13657.5" y="5279.444"/> <port id="pr_5406fe28-0f29-46a1-b875-2ca02a766f51_p1" x="13647.5" y="5284.444"/> <port id="pr_5406fe28-0f29-46a1-b875-2ca02a766f51_p2" x="13677.5" y="5284.444"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_528cc5a8-1350-40e4-8939-d9ab8a6a8cae"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:12050133 PPMID:12441302 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13864.5" y="5237.0"/> <port id="pr_528cc5a8-1350-40e4-8939-d9ab8a6a8cae_p1" x="13854.5" y="5242.0"/> <port id="pr_528cc5a8-1350-40e4-8939-d9ab8a6a8cae_p2" x="13884.5" y="5242.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_512b7e32-f78a-44c7-8825-fbb54a81cb4f"> <bbox w="10.0" h="10.0" x="14491.91" y="3778.5"/> <port id="pr_512b7e32-f78a-44c7-8825-fbb54a81cb4f_p1" x="14481.91" y="3783.5"/> <port id="pr_512b7e32-f78a-44c7-8825-fbb54a81cb4f_p2" x="14511.91" y="3783.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2e4259f7-65e0-4f87-8e70-d7e76a47f942"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20925119 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14453.0" y="3859.206"/> <port id="pr_2e4259f7-65e0-4f87-8e70-d7e76a47f942_p1" x="14443.0" y="3864.206"/> <port id="pr_2e4259f7-65e0-4f87-8e70-d7e76a47f942_p2" x="14473.0" y="3864.206"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_02b35021-f7ed-453e-ac83-54c59a3a61ad"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:19183803 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14823.25" y="4293.0"/> <port id="pr_02b35021-f7ed-453e-ac83-54c59a3a61ad_p1" x="14813.25" y="4298.0"/> <port id="pr_02b35021-f7ed-453e-ac83-54c59a3a61ad_p2" x="14843.25" y="4298.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_e06ae214-f0f9-43a7-9a42-d3be9cdba67c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15708980 PMID:14567915 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13194.0" y="4276.0"/> <port id="pr_e06ae214-f0f9-43a7-9a42-d3be9cdba67c_p1" x="13199.0" y="4296.0"/> <port id="pr_e06ae214-f0f9-43a7-9a42-d3be9cdba67c_p2" x="13199.0" y="4266.0"/> </glyph> <glyph class="uncertain process" orientation="vertical" id="pr_88465643-55a3-4cf2-a150-30f55ad09ba7"> <bbox w="10.0" h="10.0" x="13194.0" y="4197.5"/> <port id="pr_88465643-55a3-4cf2-a150-30f55ad09ba7_p1" x="13199.0" y="4217.5"/> <port id="pr_88465643-55a3-4cf2-a150-30f55ad09ba7_p2" x="13199.0" y="4187.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_898e034e-ae86-4c8c-893e-56079252a17c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15082531 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14092.453" y="3710.25"/> <port id="pr_898e034e-ae86-4c8c-893e-56079252a17c_p1" x="14082.453" y="3715.25"/> <port id="pr_898e034e-ae86-4c8c-893e-56079252a17c_p2" x="14112.453" y="3715.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_68b9f99a-0a1b-42d0-8f49-ce8094d45e03"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: This complex does not contain HDAC but do contain LEF1 PMID:17666529 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13489.5" y="3961.0"/> <port id="pr_68b9f99a-0a1b-42d0-8f49-ce8094d45e03_p1" x="13509.5" y="3966.0"/> <port id="pr_68b9f99a-0a1b-42d0-8f49-ce8094d45e03_p2" x="13479.5" y="3966.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_dd03c7e3-9185-43f8-8730-850f2db489cc"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: HIPK2 phosphorylates any TCF/LEF PMID:21285352 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14544.5" y="4257.5"/> <port id="pr_dd03c7e3-9185-43f8-8730-850f2db489cc_p1" x="14549.5" y="4277.5"/> <port id="pr_dd03c7e3-9185-43f8-8730-850f2db489cc_p2" x="14549.5" y="4247.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_cd4fcb0e-dfce-43e3-9465-064b6ef48c37"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Phosphorylated TCF/LEF transcription factor dissociates and is replaced by another unphosphorylated one. For example TCF3 (repressor) is phosphorylated by HIPK2 and will dissociate from the complex and is replaced by TCF1. PMID:21285352 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14531.875" y="4187.375"/> <port id="pr_cd4fcb0e-dfce-43e3-9465-064b6ef48c37_p1" x="14536.875" y="4177.375"/> <port id="pr_cd4fcb0e-dfce-43e3-9465-064b6ef48c37_p2" x="14536.875" y="4207.375"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a17c7b93-7bbf-4a1d-b726-b3e5635b094e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: HIPK2 phosphorylates S33 and S37 residues as GSK3 without priming b-catenin first PMID:20307497 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13942.25" y="3671.5"/> <port id="pr_a17c7b93-7bbf-4a1d-b726-b3e5635b094e_p1" x="13962.25" y="3676.5"/> <port id="pr_a17c7b93-7bbf-4a1d-b726-b3e5635b094e_p2" x="13932.25" y="3676.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c49e08d6-8e12-45bf-94bc-89cba1e94f3c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20307497 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13828.097" y="3869.5"/> <port id="pr_c49e08d6-8e12-45bf-94bc-89cba1e94f3c_p1" x="13833.097" y="3859.5"/> <port id="pr_c49e08d6-8e12-45bf-94bc-89cba1e94f3c_p2" x="13833.097" y="3889.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8e0853b8-a486-43e1-a723-75d715c1c74f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22322943 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14815.0" y="5212.125"/> <port id="pr_8e0853b8-a486-43e1-a723-75d715c1c74f_p1" x="14805.0" y="5217.125"/> <port id="pr_8e0853b8-a486-43e1-a723-75d715c1c74f_p2" x="14835.0" y="5217.125"/> </glyph> <glyph class="and" orientation="vertical" id="logicglyph_e85e24b2-b34c-4175-bf80-70eadd8bce61"> <bbox w="20.0" h="20.0" x="14809.043" y="5157.245"/> <port id="logicglyph_e85e24b2-b34c-4175-bf80-70eadd8bce61_p1" x="14819.043" y="5147.245"/> <port id="logicglyph_e85e24b2-b34c-4175-bf80-70eadd8bce61_p2" x="14819.043" y="5187.245"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_3c159b35-5461-4a6d-80e7-f0f4daf46d11"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22322943 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14972.0" y="5211.7114"/> <port id="pr_3c159b35-5461-4a6d-80e7-f0f4daf46d11_p1" x="14962.0" y="5216.7114"/> <port id="pr_3c159b35-5461-4a6d-80e7-f0f4daf46d11_p2" x="14992.0" y="5216.7114"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ee98f11a-2f45-47e0-b97b-9bd5812d521d"> <bbox w="10.0" h="10.0" x="15086.0" y="4998.601"/> <port id="pr_ee98f11a-2f45-47e0-b97b-9bd5812d521d_p1" x="15076.0" y="5003.601"/> <port id="pr_ee98f11a-2f45-47e0-b97b-9bd5812d521d_p2" x="15106.0" y="5003.601"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_100d36b3-cf89-419c-98e8-0fa19edef1b9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: SOX9 PMID:23306204 p300 transcription complex PMID:15806138 WNT-target gene: PMID:20122174 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14100.5" y="5209.0"/> <port id="pr_100d36b3-cf89-419c-98e8-0fa19edef1b9_p1" x="14090.5" y="5214.0"/> <port id="pr_100d36b3-cf89-419c-98e8-0fa19edef1b9_p2" x="14120.5" y="5214.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_52f9210c-9e09-4ff8-8db9-bb8c09b94772"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Transcription complex containing b-catenin and P300 PMID:17050667 PMID:21767405 RAD6B is overexpressed in breast cancer PMID:11929833 RAD6B upregulated in invasive breast cancer PMID:22705350 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14100.5" y="5251.0"/> <port id="pr_52f9210c-9e09-4ff8-8db9-bb8c09b94772_p1" x="14090.5" y="5256.0"/> <port id="pr_52f9210c-9e09-4ff8-8db9-bb8c09b94772_p2" x="14120.5" y="5256.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a513fbac-1128-48b3-99c4-a1369fb4b16c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: BCL9 is a target gene of the wnt pathway. PMID:18627596 However not known which transcription complex is involved either with CBP or P300. I have chosen this complex randomly References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14333.5" y="5166.0"/> <port id="pr_a513fbac-1128-48b3-99c4-a1369fb4b16c_p1" x="14323.5" y="5171.0"/> <port id="pr_a513fbac-1128-48b3-99c4-a1369fb4b16c_p2" x="14353.5" y="5171.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d09c660b-4e04-48a2-83e2-f4fc7fda65e2"> <bbox w="10.0" h="10.0" x="14014.25" y="5131.381"/> <port id="pr_d09c660b-4e04-48a2-83e2-f4fc7fda65e2_p1" x="14004.25" y="5136.381"/> <port id="pr_d09c660b-4e04-48a2-83e2-f4fc7fda65e2_p2" x="14034.25" y="5136.381"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5fb8ba47-ba94-4343-b732-26cc2a1277eb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: LEF1 has been identified to be involved in transcription of the MIR371-373 cluster. Only unknown if either P300 or CTBP is involved. PMID:22020335 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13240.25" y="5087.0"/> <port id="pr_5fb8ba47-ba94-4343-b732-26cc2a1277eb_p1" x="13230.25" y="5092.0"/> <port id="pr_5fb8ba47-ba94-4343-b732-26cc2a1277eb_p2" x="13260.25" y="5092.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_fb67ae16-c59c-4c91-893f-fe693a7b9693"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: LEF1 has been identified to be involved in transcription of the MIR371-373 cluster. Only unknown if either P300 or CTBP is involved. PMID:22020335 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13240.25" y="5124.0"/> <port id="pr_fb67ae16-c59c-4c91-893f-fe693a7b9693_p1" x="13230.25" y="5129.0"/> <port id="pr_fb67ae16-c59c-4c91-893f-fe693a7b9693_p2" x="13260.25" y="5129.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f6aa8f26-651c-403f-97ec-32ee18353260"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22020335 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13376.5" y="5111.0"/> <port id="pr_f6aa8f26-651c-403f-97ec-32ee18353260_p1" x="13366.5" y="5116.0"/> <port id="pr_f6aa8f26-651c-403f-97ec-32ee18353260_p2" x="13396.5" y="5116.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_e2ae200b-28db-4c19-8012-cadeb9731603"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22020335 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13447.0" y="5116.0303"/> <port id="pr_e2ae200b-28db-4c19-8012-cadeb9731603_p1" x="13437.0" y="5121.0303"/> <port id="pr_e2ae200b-28db-4c19-8012-cadeb9731603_p2" x="13467.0" y="5121.0303"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_86017df2-c98e-424f-b205-cd05a38ff4c7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Though not known if this transcription is mediated by CBP in the transcripoition complex could be otherwise P300 PMID:23296977 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14333.5" y="5211.0"/> <port id="pr_86017df2-c98e-424f-b205-cd05a38ff4c7_p1" x="14323.5" y="5216.0"/> <port id="pr_86017df2-c98e-424f-b205-cd05a38ff4c7_p2" x="14353.5" y="5216.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_0029f063-287e-4adf-8cb9-91fc7f3e532c"> <bbox w="10.0" h="10.0" x="14321.37" y="5374.75"/> <port id="pr_0029f063-287e-4adf-8cb9-91fc7f3e532c_p1" x="14326.37" y="5364.75"/> <port id="pr_0029f063-287e-4adf-8cb9-91fc7f3e532c_p2" x="14326.37" y="5394.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_1cf8c549-8968-4f65-b4c5-775bbded12cf"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Not known if P300 transcription complex mediates this trancription either it is CBP transcription complex PMID:17291450 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14333.5" y="5253.0"/> <port id="pr_1cf8c549-8968-4f65-b4c5-775bbded12cf_p1" x="14323.5" y="5258.0"/> <port id="pr_1cf8c549-8968-4f65-b4c5-775bbded12cf_p2" x="14353.5" y="5258.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6ad19127-d4c3-411e-9236-236fd4ebd13d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: Contains a NES PMID:15720724 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14963.5" y="4361.0"/> <port id="pr_6ad19127-d4c3-411e-9236-236fd4ebd13d_p1" x="14953.5" y="4366.0"/> <port id="pr_6ad19127-d4c3-411e-9236-236fd4ebd13d_p2" x="14983.5" y="4366.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ca2f1a48-5836-4e47-8d98-b211492b1370"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: contains NLS import higher when stimulated with wnt3 PMID:15720724 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14963.5" y="4341.0"/> <port id="pr_ca2f1a48-5836-4e47-8d98-b211492b1370_p1" x="14983.5" y="4346.0"/> <port id="pr_ca2f1a48-5836-4e47-8d98-b211492b1370_p2" x="14953.5" y="4346.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_e6018a0b-4a36-48b7-abf1-5adb88ab5d3c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Upon WNT3a stimulation formation complex DVL with c-jun PMID:18347071 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="14658.0" y="4388.375"/> <port id="pr_e6018a0b-4a36-48b7-abf1-5adb88ab5d3c_p1" x="14663.0" y="4378.375"/> <port id="pr_e6018a0b-4a36-48b7-abf1-5adb88ab5d3c_p2" x="14663.0" y="4408.375"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a0ca0dc7-87c4-492c-8562-c0b39f398ebe"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18347071 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="13551.452" y="4097.0"/> <port id="pr_a0ca0dc7-87c4-492c-8562-c0b39f398ebe_p1" x="13556.452" y="4087.0"/> <port id="pr_a0ca0dc7-87c4-492c-8562-c0b39f398ebe_p2" x="13556.452" y="4117.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_2b3852f8-4c4f-4f18-8981-5dc524b661cc"> <bbox w="10.0" h="10.0" x="15035.348" y="4012.0"/> <port id="pr_2b3852f8-4c4f-4f18-8981-5dc524b661cc_p1" x="15040.348" y="4002.0"/> <port id="pr_2b3852f8-4c4f-4f18-8981-5dc524b661cc_p2" x="15040.348" y="4032.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_fe7d2a25-9a29-4f22-97b7-dbe04ec2e7a1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22699938 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15672.0" y="3229.3438"/> <port id="pr_fe7d2a25-9a29-4f22-97b7-dbe04ec2e7a1_p1" x="15677.0" y="3219.3438"/> <port id="pr_fe7d2a25-9a29-4f22-97b7-dbe04ec2e7a1_p2" x="15677.0" y="3249.3438"/> </glyph> <glyph class="process" orientation="vertical" id="pr_760dfbaa-421f-4b2f-b989-9229f573aa1f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: NLS has been found in KINDLIN2 PMID:22699938 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15699.0" y="3413.0"/> <port id="pr_760dfbaa-421f-4b2f-b989-9229f573aa1f_p1" x="15704.0" y="3403.0"/> <port id="pr_760dfbaa-421f-4b2f-b989-9229f573aa1f_p2" x="15704.0" y="3433.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_15a4fd3c-299a-4319-b171-52fcd6aca398"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22699938 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15837.0" y="3517.262"/> <port id="pr_15a4fd3c-299a-4319-b171-52fcd6aca398_p1" x="15827.0" y="3522.262"/> <port id="pr_15a4fd3c-299a-4319-b171-52fcd6aca398_p2" x="15857.0" y="3522.262"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_91ba47fe-9895-4468-9be6-d260b8ab4a9c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22699938 E2F1 PMID:15766563 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15962.0" y="3670.0"/> <port id="pr_91ba47fe-9895-4468-9be6-d260b8ab4a9c_p1" x="15952.0" y="3675.0"/> <port id="pr_91ba47fe-9895-4468-9be6-d260b8ab4a9c_p2" x="15982.0" y="3675.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2aa71bf8-fb17-4568-969d-2667eae17ed6"> <bbox w="10.0" h="10.0" x="15798.0" y="5236.0"/> <port id="pr_2aa71bf8-fb17-4568-969d-2667eae17ed6_p1" x="15788.0" y="5241.0"/> <port id="pr_2aa71bf8-fb17-4568-969d-2667eae17ed6_p2" x="15818.0" y="5241.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ff6afae8-4ec4-4b9b-ab0d-b95f85eb3ef3"> <bbox w="10.0" h="10.0" x="16029.0" y="5236.0"/> <port id="pr_ff6afae8-4ec4-4b9b-ab0d-b95f85eb3ef3_p1" x="16019.0" y="5241.0"/> <port id="pr_ff6afae8-4ec4-4b9b-ab0d-b95f85eb3ef3_p2" x="16049.0" y="5241.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_b3201b8f-c708-4ee2-8398-d93c4bb094be"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMD:23396279 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="16145.5" y="5121.7627"/> <port id="pr_b3201b8f-c708-4ee2-8398-d93c4bb094be_p1" x="16135.5" y="5126.7627"/> <port id="pr_b3201b8f-c708-4ee2-8398-d93c4bb094be_p2" x="16165.5" y="5126.7627"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_e1d993bb-9848-4089-a1b1-866faf763e5e"> <bbox w="10.0" h="10.0" x="16029.0" y="5194.0"/> <port id="pr_e1d993bb-9848-4089-a1b1-866faf763e5e_p1" x="16019.0" y="5199.0"/> <port id="pr_e1d993bb-9848-4089-a1b1-866faf763e5e_p2" x="16049.0" y="5199.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_85270fc8-bffb-4848-8e95-53cbdd46f804"> <bbox w="10.0" h="10.0" x="15798.0" y="5202.0"/> <port id="pr_85270fc8-bffb-4848-8e95-53cbdd46f804_p1" x="15788.0" y="5207.0"/> <port id="pr_85270fc8-bffb-4848-8e95-53cbdd46f804_p2" x="15818.0" y="5207.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_36ae4928-8b49-43c1-8985-69db19d269e0"> <bbox w="10.0" h="10.0" x="16029.0" y="5159.0"/> <port id="pr_36ae4928-8b49-43c1-8985-69db19d269e0_p1" x="16019.0" y="5164.0"/> <port id="pr_36ae4928-8b49-43c1-8985-69db19d269e0_p2" x="16049.0" y="5164.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_983433a5-5f87-4a71-9ae4-671fa352786c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:23321667 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="16113.275" y="5089.246"/> <port id="pr_983433a5-5f87-4a71-9ae4-671fa352786c_p1" x="16118.275" y="5109.246"/> <port id="pr_983433a5-5f87-4a71-9ae4-671fa352786c_p2" x="16118.275" y="5079.246"/> </glyph> <glyph class="process" orientation="vertical" id="pr_3af11b5f-47ab-41b7-902e-e73e83409ce3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:23321667 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="16171.171" y="5063.25"/> <port id="pr_3af11b5f-47ab-41b7-902e-e73e83409ce3_p1" x="16176.171" y="5083.25"/> <port id="pr_3af11b5f-47ab-41b7-902e-e73e83409ce3_p2" x="16176.171" y="5053.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_cda32f18-7c46-4147-9c42-92dc23241980"> <bbox w="10.0" h="10.0" x="16181.645" y="5140.0"/> <port id="pr_cda32f18-7c46-4147-9c42-92dc23241980_p1" x="16186.645" y="5130.0"/> <port id="pr_cda32f18-7c46-4147-9c42-92dc23241980_p2" x="16186.645" y="5160.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b570fb1a-47e4-4f7c-a324-97a7a58f55b0"> <bbox w="10.0" h="10.0" x="16233.451" y="5139.0"/> <port id="pr_b570fb1a-47e4-4f7c-a324-97a7a58f55b0_p1" x="16238.451" y="5129.0"/> <port id="pr_b570fb1a-47e4-4f7c-a324-97a7a58f55b0_p2" x="16238.451" y="5159.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_8659e415-3b9c-4cd5-bc77-4352ce385619"> <bbox w="10.0" h="10.0" x="16233.373" y="5186.0"/> <port id="pr_8659e415-3b9c-4cd5-bc77-4352ce385619_p1" x="16238.373" y="5176.0"/> <port id="pr_8659e415-3b9c-4cd5-bc77-4352ce385619_p2" x="16238.373" y="5206.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6e23d096-f3e8-4731-9d9d-a896ea3d4557"> <bbox w="10.0" h="10.0" x="15962.0" y="3718.0"/> <port id="pr_6e23d096-f3e8-4731-9d9d-a896ea3d4557_p1" x="15952.0" y="3723.0"/> <port id="pr_6e23d096-f3e8-4731-9d9d-a896ea3d4557_p2" x="15982.0" y="3723.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_28649d46-84a7-4aad-9d0f-c3ef1755dc0c"> <bbox w="10.0" h="10.0" x="15962.0" y="3766.0"/> <port id="pr_28649d46-84a7-4aad-9d0f-c3ef1755dc0c_p1" x="15952.0" y="3771.0"/> <port id="pr_28649d46-84a7-4aad-9d0f-c3ef1755dc0c_p2" x="15982.0" y="3771.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_11eb87da-6558-4485-b87a-350b2bd45d18"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22833265 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="16136.5" y="3744.5"/> <port id="pr_11eb87da-6558-4485-b87a-350b2bd45d18_p1" x="16126.5" y="3749.5"/> <port id="pr_11eb87da-6558-4485-b87a-350b2bd45d18_p2" x="16156.5" y="3749.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_289d44cc-8adb-4359-be05-1ca40be40a69"> <bbox w="10.0" h="10.0" x="15962.0" y="3809.0"/> <port id="pr_289d44cc-8adb-4359-be05-1ca40be40a69_p1" x="15952.0" y="3814.0"/> <port id="pr_289d44cc-8adb-4359-be05-1ca40be40a69_p2" x="15982.0" y="3814.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_4c9ffea4-e486-4a24-ac7e-1966d1122756"> <bbox w="10.0" h="10.0" x="15962.0" y="3849.0"/> <port id="pr_4c9ffea4-e486-4a24-ac7e-1966d1122756_p1" x="15952.0" y="3854.0"/> <port id="pr_4c9ffea4-e486-4a24-ac7e-1966d1122756_p2" x="15982.0" y="3854.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_75cb8072-ff4f-4306-bdf0-c1e17f54fe83"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22833265 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="16137.25" y="3840.5"/> <port id="pr_75cb8072-ff4f-4306-bdf0-c1e17f54fe83_p1" x="16127.25" y="3845.5"/> <port id="pr_75cb8072-ff4f-4306-bdf0-c1e17f54fe83_p2" x="16157.25" y="3845.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_810ce438-4ade-435b-82af-39c80d39e4db"> <bbox w="10.0" h="10.0" x="15962.0" y="3908.0"/> <port id="pr_810ce438-4ade-435b-82af-39c80d39e4db_p1" x="15952.0" y="3913.0"/> <port id="pr_810ce438-4ade-435b-82af-39c80d39e4db_p2" x="15982.0" y="3913.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_cd23b71a-7ba5-4efb-9f9e-e6b761a542d1"> <bbox w="10.0" h="10.0" x="15962.0" y="3947.0"/> <port id="pr_cd23b71a-7ba5-4efb-9f9e-e6b761a542d1_p1" x="15952.0" y="3952.0"/> <port id="pr_cd23b71a-7ba5-4efb-9f9e-e6b761a542d1_p2" x="15982.0" y="3952.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_caa31c37-5fe7-48bc-a824-d3c1e00a952d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22833265 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="16137.25" y="3933.5"/> <port id="pr_caa31c37-5fe7-48bc-a824-d3c1e00a952d_p1" x="16127.25" y="3938.5"/> <port id="pr_caa31c37-5fe7-48bc-a824-d3c1e00a952d_p2" x="16157.25" y="3938.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_fa5b16db-863d-420f-90e1-dbf9c14f9bc1"> <bbox w="10.0" h="10.0" x="15962.0" y="4006.0"/> <port id="pr_fa5b16db-863d-420f-90e1-dbf9c14f9bc1_p1" x="15952.0" y="4011.0"/> <port id="pr_fa5b16db-863d-420f-90e1-dbf9c14f9bc1_p2" x="15982.0" y="4011.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_10243df0-e7cd-4e2e-823b-28a7802676d6"> <bbox w="10.0" h="10.0" x="15962.0" y="4045.0"/> <port id="pr_10243df0-e7cd-4e2e-823b-28a7802676d6_p1" x="15952.0" y="4050.0"/> <port id="pr_10243df0-e7cd-4e2e-823b-28a7802676d6_p2" x="15982.0" y="4050.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_68776cb0-90c7-4b99-8e41-db1b841cc93f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:22833265 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="16139.5" y="4030.0"/> <port id="pr_68776cb0-90c7-4b99-8e41-db1b841cc93f_p1" x="16129.5" y="4035.0"/> <port id="pr_68776cb0-90c7-4b99-8e41-db1b841cc93f_p2" x="16159.5" y="4035.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1d533c75-dc8d-4bf8-b605-ca6c5dca2c59"> <bbox w="10.0" h="10.0" x="16294.354" y="3811.25"/> <port id="pr_1d533c75-dc8d-4bf8-b605-ca6c5dca2c59_p1" x="16299.354" y="3801.25"/> <port id="pr_1d533c75-dc8d-4bf8-b605-ca6c5dca2c59_p2" x="16299.354" y="3831.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_794bf603-f11b-49c4-b550-e344638daffa"> <bbox w="10.0" h="10.0" x="16291.5" y="3862.4702"/> <port id="pr_794bf603-f11b-49c4-b550-e344638daffa_p1" x="16281.5" y="3867.4702"/> <port id="pr_794bf603-f11b-49c4-b550-e344638daffa_p2" x="16311.5" y="3867.4702"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_eb518e12-6e0c-4ea1-8bfe-f43a461f306e"> <bbox w="10.0" h="10.0" x="16292.0" y="3916.588"/> <port id="pr_eb518e12-6e0c-4ea1-8bfe-f43a461f306e_p1" x="16282.0" y="3921.588"/> <port id="pr_eb518e12-6e0c-4ea1-8bfe-f43a461f306e_p2" x="16312.0" y="3921.588"/> </glyph> <glyph class="process" orientation="vertical" id="pr_60d09990-44eb-4527-b489-89a13a581d73"> <bbox w="10.0" h="10.0" x="16293.963" y="3969.0"/> <port id="pr_60d09990-44eb-4527-b489-89a13a581d73_p1" x="16298.963" y="3989.0"/> <port id="pr_60d09990-44eb-4527-b489-89a13a581d73_p2" x="16298.963" y="3959.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5710862c-357f-485a-95a3-ce86bac63554"> <bbox w="10.0" h="10.0" x="15825.0" y="4123.0"/> <port id="pr_5710862c-357f-485a-95a3-ce86bac63554_p1" x="15815.0" y="4128.0"/> <port id="pr_5710862c-357f-485a-95a3-ce86bac63554_p2" x="15845.0" y="4128.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6c497478-2338-429a-a517-a843b539df57"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:20439735 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15966.5" y="4123.0"/> <port id="pr_6c497478-2338-429a-a517-a843b539df57_p1" x="15956.5" y="4128.0"/> <port id="pr_6c497478-2338-429a-a517-a843b539df57_p2" x="15986.5" y="4128.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ccaf5231-f099-4c0f-8954-39dc837bfb96"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:20439735 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="16125.5" y="4167.0"/> <port id="pr_ccaf5231-f099-4c0f-8954-39dc837bfb96_p1" x="16115.5" y="4172.0"/> <port id="pr_ccaf5231-f099-4c0f-8954-39dc837bfb96_p2" x="16145.5" y="4172.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f4ff347c-a7c0-4489-b3a8-d4d5ee91b443"> <bbox w="10.0" h="10.0" x="15771.75" y="4298.0"/> <port id="pr_f4ff347c-a7c0-4489-b3a8-d4d5ee91b443_p1" x="15761.75" y="4303.0"/> <port id="pr_f4ff347c-a7c0-4489-b3a8-d4d5ee91b443_p2" x="15791.75" y="4303.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_59e8b15d-3af3-468c-b5d1-edd8fa492f48"> <bbox w="10.0" h="10.0" x="15921.25" y="4298.0"/> <port id="pr_59e8b15d-3af3-468c-b5d1-edd8fa492f48_p1" x="15911.25" y="4303.0"/> <port id="pr_59e8b15d-3af3-468c-b5d1-edd8fa492f48_p2" x="15941.25" y="4303.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_8d7206f5-407c-4ffc-af61-7c9285f9528c"> <bbox w="10.0" h="10.0" x="16124.5" y="3560.5"/> <port id="pr_8d7206f5-407c-4ffc-af61-7c9285f9528c_p1" x="16129.5" y="3580.5"/> <port id="pr_8d7206f5-407c-4ffc-af61-7c9285f9528c_p2" x="16129.5" y="3550.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8d46b514-aac9-4ef1-b3ff-02c031608a74"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:15611123 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="16120.5" y="3669.4316"/> <port id="pr_8d46b514-aac9-4ef1-b3ff-02c031608a74_p1" x="16110.5" y="3674.4316"/> <port id="pr_8d46b514-aac9-4ef1-b3ff-02c031608a74_p2" x="16140.5" y="3674.4316"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_e961f312-8802-4c2b-b51a-328526a68c7a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:WNT_CANONICAL Maps_Modules_end References_begin: PMID:18362162 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="15771.75" y="4347.75"/> <port id="pr_e961f312-8802-4c2b-b51a-328526a68c7a_p1" x="15761.75" y="4352.75"/> <port id="pr_e961f312-8802-4c2b-b51a-328526a68c7a_p2" x="15791.75" y="4352.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_0c822aab-e049-4242-b2f7-d9ea8e8ff82d"> <bbox w="10.0" h="10.0" x="15921.25" y="4347.75"/> <port id="pr_0c822aab-e049-4242-b2f7-d9ea8e8ff82d_p1" x="15911.25" y="4352.75"/> <port id="pr_0c822aab-e049-4242-b2f7-d9ea8e8ff82d_p2" x="15941.25" y="4352.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a86ace11-07af-483f-8b99-d77eefb5d1ce"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17283082 PMID:19147008 GLI2 ompletely degraded no truncated form present PMID:16611981 Truncated form of GLI2 is produced References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18100.375" y="1813.0269"/> <port id="pr_a86ace11-07af-483f-8b99-d77eefb5d1ce_p1" x="18105.375" y="1803.0269"/> <port id="pr_a86ace11-07af-483f-8b99-d77eefb5d1ce_p2" x="18105.375" y="1833.0269"/> </glyph> <glyph class="process" orientation="vertical" id="pr_67d02ef9-15cd-4005-8561-7b6c49e7c238"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID17283082. A domain in the a.a. sequence favors the truncation of the protein References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18429.287" y="1812.8851"/> <port id="pr_67d02ef9-15cd-4005-8561-7b6c49e7c238_p1" x="18434.287" y="1802.8851"/> <port id="pr_67d02ef9-15cd-4005-8561-7b6c49e7c238_p2" x="18434.287" y="1832.8851"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_e328af47-7edc-420f-b568-4f82a72c0a77"> <bbox w="10.0" h="10.0" x="19208.414" y="176.82388"/> <port id="pr_e328af47-7edc-420f-b568-4f82a72c0a77_p1" x="19228.414" y="181.82388"/> <port id="pr_e328af47-7edc-420f-b568-4f82a72c0a77_p2" x="19198.414" y="181.82388"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d161d8a4-31d5-41d8-afc1-f4b1a735a370"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17641202 PMID:20889716 Tulp3 inhibits MODULE:HEDGEHOG signaling but how exactly is unknown References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18933.25" y="172.5"/> <port id="pr_d161d8a4-31d5-41d8-afc1-f4b1a735a370_p1" x="18953.25" y="177.5"/> <port id="pr_d161d8a4-31d5-41d8-afc1-f4b1a735a370_p2" x="18923.25" y="177.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_971ebf0c-bf1a-4d5b-9a65-1613bc294af6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:10021362 PMID:18815277 PMID:17430994 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18556.184" y="294.77512"/> <port id="pr_971ebf0c-bf1a-4d5b-9a65-1613bc294af6_p1" x="18576.184" y="299.77512"/> <port id="pr_971ebf0c-bf1a-4d5b-9a65-1613bc294af6_p2" x="18546.184" y="299.77512"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_3c41b30a-558b-43f3-91e8-89f9f4765756"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17430994 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18383.375" y="225.14566"/> <port id="pr_3c41b30a-558b-43f3-91e8-89f9f4765756_p1" x="18403.375" y="230.14566"/> <port id="pr_3c41b30a-558b-43f3-91e8-89f9f4765756_p2" x="18373.375" y="230.14566"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2d4ba223-641b-4290-b82b-31c6390f3edf"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:15618519 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18593.062" y="440.75"/> <port id="pr_2d4ba223-641b-4290-b82b-31c6390f3edf_p1" x="18583.062" y="445.75"/> <port id="pr_2d4ba223-641b-4290-b82b-31c6390f3edf_p2" x="18613.062" y="445.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_0d8e354b-fe7b-4ced-b3d6-9903b0257b7a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18497258 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18814.441" y="321.49475"/> <port id="pr_0d8e354b-fe7b-4ced-b3d6-9903b0257b7a_p1" x="18804.441" y="326.49475"/> <port id="pr_0d8e354b-fe7b-4ced-b3d6-9903b0257b7a_p2" x="18834.441" y="326.49475"/> </glyph> <glyph class="process" orientation="vertical" id="pr_7649fe89-c6c0-4b84-a85b-0d3aa6d5191b"> <bbox w="10.0" h="10.0" x="19326.074" y="521.375"/> <port id="pr_7649fe89-c6c0-4b84-a85b-0d3aa6d5191b_p1" x="19331.074" y="541.375"/> <port id="pr_7649fe89-c6c0-4b84-a85b-0d3aa6d5191b_p2" x="19331.074" y="511.375"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_83f6a107-4df1-4c17-a8bc-3cd60d7754f6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18497258 PMID:11449277 PMID:20375059 Rad23 negatively regulates SHH signaling but how exactly is unknown. Recently it was shown to be associated with Smo trafficing into cilium References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19081.5" y="430.75"/> <port id="pr_83f6a107-4df1-4c17-a8bc-3cd60d7754f6_p1" x="19071.5" y="435.75"/> <port id="pr_83f6a107-4df1-4c17-a8bc-3cd60d7754f6_p2" x="19101.5" y="435.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_eff265b1-555d-4385-8ce0-6907ed6f4c41"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20956384 PMID:19592253 PMID:0643644 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18155.625" y="466.919"/> <port id="pr_eff265b1-555d-4385-8ce0-6907ed6f4c41_p1" x="18145.625" y="471.919"/> <port id="pr_eff265b1-555d-4385-8ce0-6907ed6f4c41_p2" x="18175.625" y="471.919"/> </glyph> <glyph class="process" orientation="vertical" id="pr_78bccc99-37f2-4909-bd33-bc2188450f7e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20956384 PMID:19592253 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18186.137" y="674.5625"/> <port id="pr_78bccc99-37f2-4909-bd33-bc2188450f7e_p1" x="18191.137" y="694.5625"/> <port id="pr_78bccc99-37f2-4909-bd33-bc2188450f7e_p2" x="18191.137" y="664.5625"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_28c3c282-e1cc-4c57-8e3a-ff48953bea6c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20956384 PMID:21209912 PMID:19549984 PMID:19592253 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18948.75" y="456.25"/> <port id="pr_28c3c282-e1cc-4c57-8e3a-ff48953bea6c_p1" x="18938.75" y="461.25"/> <port id="pr_28c3c282-e1cc-4c57-8e3a-ff48953bea6c_p2" x="18968.75" y="461.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9670f83b-b04f-42bc-9dd3-f2efd97be439"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20956384 PMID:21209912 PMID:19549984 PMID:19592253 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18953.25" y="642.5"/> <port id="pr_9670f83b-b04f-42bc-9dd3-f2efd97be439_p1" x="18943.25" y="647.5"/> <port id="pr_9670f83b-b04f-42bc-9dd3-f2efd97be439_p2" x="18973.25" y="647.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_29d712f1-20ea-4cb0-8567-03e14ac24281"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20956384 PMID:20643644 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19752.688" y="402.18433"/> <port id="pr_29d712f1-20ea-4cb0-8567-03e14ac24281_p1" x="19742.688" y="407.18433"/> <port id="pr_29d712f1-20ea-4cb0-8567-03e14ac24281_p2" x="19772.688" y="407.18433"/> </glyph> <glyph class="and" orientation="vertical" id="logicglyph_7a4a2f04-220c-44e5-a4b7-6b4592db790b"> <bbox w="20.0" h="20.0" x="19613.473" y="230.70186"/> <port id="logicglyph_7a4a2f04-220c-44e5-a4b7-6b4592db790b_p1" x="19623.473" y="220.70186"/> <port id="logicglyph_7a4a2f04-220c-44e5-a4b7-6b4592db790b_p2" x="19623.473" y="260.70184"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_92ec7fac-b93a-487b-a231-5da2f81c54cf"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20956384 PMID:20643644 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19803.688" y="544.8134"/> <port id="pr_92ec7fac-b93a-487b-a231-5da2f81c54cf_p1" x="19793.688" y="549.8134"/> <port id="pr_92ec7fac-b93a-487b-a231-5da2f81c54cf_p2" x="19823.688" y="549.8134"/> </glyph> <glyph class="and" orientation="vertical" id="logicglyph_b77300a0-9d75-4c81-b8cf-5fd209ac7acf"> <bbox w="20.0" h="20.0" x="19613.441" y="318.90414"/> <port id="logicglyph_b77300a0-9d75-4c81-b8cf-5fd209ac7acf_p1" x="19623.441" y="308.90414"/> <port id="logicglyph_b77300a0-9d75-4c81-b8cf-5fd209ac7acf_p2" x="19623.441" y="348.90414"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_7faaa3c0-7351-4dd0-9846-fa571f186008"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20956384 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18963.0" y="393.0"/> <port id="pr_7faaa3c0-7351-4dd0-9846-fa571f186008_p1" x="18983.0" y="398.0"/> <port id="pr_7faaa3c0-7351-4dd0-9846-fa571f186008_p2" x="18953.0" y="398.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_17d42cab-90fb-462c-bfaa-be4926b1a4d6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21209912 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18829.5" y="561.0"/> <port id="pr_17d42cab-90fb-462c-bfaa-be4926b1a4d6_p1" x="18819.5" y="566.0"/> <port id="pr_17d42cab-90fb-462c-bfaa-be4926b1a4d6_p2" x="18849.5" y="566.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_61b4babe-2bce-4f26-bbbb-977ee4904d30"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20643644 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19396.207" y="810.668"/> <port id="pr_61b4babe-2bce-4f26-bbbb-977ee4904d30_p1" x="19386.207" y="815.668"/> <port id="pr_61b4babe-2bce-4f26-bbbb-977ee4904d30_p2" x="19416.207" y="815.668"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ee4f912c-31e0-4a96-9ebf-1e6efb310950"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20643644 PMID:19878745 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19876.457" y="585.7734"/> <port id="pr_ee4f912c-31e0-4a96-9ebf-1e6efb310950_p1" x="19881.457" y="575.7734"/> <port id="pr_ee4f912c-31e0-4a96-9ebf-1e6efb310950_p2" x="19881.457" y="605.7734"/> </glyph> <glyph class="uncertain process" orientation="vertical" id="pr_a36db2d6-53d7-43a9-bc39-b3028563f9e7"> <bbox w="10.0" h="10.0" x="20008.75" y="637.334"/> <port id="pr_a36db2d6-53d7-43a9-bc39-b3028563f9e7_p1" x="20013.75" y="627.334"/> <port id="pr_a36db2d6-53d7-43a9-bc39-b3028563f9e7_p2" x="20013.75" y="657.334"/> </glyph> <glyph class="process" orientation="vertical" id="pr_23275ffb-152c-4f8c-a9e8-fc57683403c4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20360384 PMID:19996169 PMID:18559511 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19855.96" y="1355.0"/> <port id="pr_23275ffb-152c-4f8c-a9e8-fc57683403c4_p1" x="19860.96" y="1345.0"/> <port id="pr_23275ffb-152c-4f8c-a9e8-fc57683403c4_p2" x="19860.96" y="1375.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_dcf1412f-bdb3-4c57-bbaa-30977feadfbc"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20016067 the PTC receptor itself does not trigger the activation of PKA but the withdrawal of the SHH ligand does PMID:16537363 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19260.375" y="868.8135"/> <port id="pr_dcf1412f-bdb3-4c57-bbaa-30977feadfbc_p1" x="19250.375" y="873.8135"/> <port id="pr_dcf1412f-bdb3-4c57-bbaa-30977feadfbc_p2" x="19280.375" y="873.8135"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_409c9697-3e3f-44aa-bc14-bdfc8e340ddb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20016067 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19087.0" y="647.0"/> <port id="pr_409c9697-3e3f-44aa-bc14-bdfc8e340ddb_p1" x="19107.0" y="652.0"/> <port id="pr_409c9697-3e3f-44aa-bc14-bdfc8e340ddb_p2" x="19077.0" y="652.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ed5c5b4b-e42f-4fa4-8240-343a8bf2a386"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20016067 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19273.2" y="1259.5"/> <port id="pr_ed5c5b4b-e42f-4fa4-8240-343a8bf2a386_p1" x="19278.2" y="1249.5"/> <port id="pr_ed5c5b4b-e42f-4fa4-8240-343a8bf2a386_p2" x="19278.2" y="1279.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2d28e4fc-7af4-4e22-abfc-d67fe58bff94"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20016067 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19288.375" y="938.0779"/> <port id="pr_2d28e4fc-7af4-4e22-abfc-d67fe58bff94_p1" x="19308.375" y="943.0779"/> <port id="pr_2d28e4fc-7af4-4e22-abfc-d67fe58bff94_p2" x="19278.375" y="943.0779"/> </glyph> <glyph class="process" orientation="vertical" id="pr_0be9ad5c-df28-4031-875a-76b838497d7f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19996169 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19582.645" y="1354.0"/> <port id="pr_0be9ad5c-df28-4031-875a-76b838497d7f_p1" x="19587.645" y="1344.0"/> <port id="pr_0be9ad5c-df28-4031-875a-76b838497d7f_p2" x="19587.645" y="1374.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6460c20a-d923-42d7-9d26-8bc53f8bc7fb"> <bbox w="10.0" h="10.0" x="19815.5" y="1281.9666"/> <port id="pr_6460c20a-d923-42d7-9d26-8bc53f8bc7fb_p1" x="19835.5" y="1286.9666"/> <port id="pr_6460c20a-d923-42d7-9d26-8bc53f8bc7fb_p2" x="19805.5" y="1286.9666"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_95503dc1-3f2b-496a-86bb-61ccbb9a773b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19488.0" y="1304.0"/> <port id="pr_95503dc1-3f2b-496a-86bb-61ccbb9a773b_p1" x="19508.0" y="1309.0"/> <port id="pr_95503dc1-3f2b-496a-86bb-61ccbb9a773b_p2" x="19478.0" y="1309.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c711f0b9-eb42-4fa2-8ac7-197342496ca3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16371461 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19156.0" y="1304.0"/> <port id="pr_c711f0b9-eb42-4fa2-8ac7-197342496ca3_p1" x="19176.0" y="1309.0"/> <port id="pr_c711f0b9-eb42-4fa2-8ac7-197342496ca3_p2" x="19146.0" y="1309.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c1bef285-82d5-4927-ae55-198305d821be"> <bbox w="10.0" h="10.0" x="18990.0" y="1571.2378"/> <port id="pr_c1bef285-82d5-4927-ae55-198305d821be_p1" x="18995.0" y="1561.2378"/> <port id="pr_c1bef285-82d5-4927-ae55-198305d821be_p2" x="18995.0" y="1591.2378"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_49050b0c-8b4d-4def-9601-e4e05fcb0e17"> <bbox w="10.0" h="10.0" x="18569.412" y="1634.2703"/> <port id="pr_49050b0c-8b4d-4def-9601-e4e05fcb0e17_p1" x="18589.412" y="1639.2703"/> <port id="pr_49050b0c-8b4d-4def-9601-e4e05fcb0e17_p2" x="18559.412" y="1639.2703"/> </glyph> <glyph class="process" orientation="vertical" id="pr_3fb998b1-898d-4220-9ba8-a7408cb9f7d8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16371461 PMID:16651270 Gli3 ubi by bTrCP1 PMID:18813803 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18990.0" y="1399.5"/> <port id="pr_3fb998b1-898d-4220-9ba8-a7408cb9f7d8_p1" x="18995.0" y="1389.5"/> <port id="pr_3fb998b1-898d-4220-9ba8-a7408cb9f7d8_p2" x="18995.0" y="1419.5"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_905bc4d5-6341-4a0f-9dc6-9a978b2b5e35"> <bbox w="20.0" h="20.0" x="18834.5" y="1300.25"/> <port id="logicglyph_905bc4d5-6341-4a0f-9dc6-9a978b2b5e35_p1" x="18824.5" y="1310.25"/> <port id="logicglyph_905bc4d5-6341-4a0f-9dc6-9a978b2b5e35_p2" x="18864.5" y="1310.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_7649a5da-2bc1-4b23-9c89-107b230136f4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16611981 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18234.375" y="1053.0"/> <port id="pr_7649a5da-2bc1-4b23-9c89-107b230136f4_p1" x="18224.375" y="1058.0"/> <port id="pr_7649a5da-2bc1-4b23-9c89-107b230136f4_p2" x="18254.375" y="1058.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_54b3d117-c816-40f8-9b83-619c9d80cbc6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16611981 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18516.625" y="1053.0"/> <port id="pr_54b3d117-c816-40f8-9b83-619c9d80cbc6_p1" x="18506.625" y="1058.0"/> <port id="pr_54b3d117-c816-40f8-9b83-619c9d80cbc6_p2" x="18536.625" y="1058.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_e037e5d4-152a-44de-965e-0c23fe3ed54d"> <bbox w="10.0" h="10.0" x="18283.375" y="1318.0344"/> <port id="pr_e037e5d4-152a-44de-965e-0c23fe3ed54d_p1" x="18303.375" y="1323.0344"/> <port id="pr_e037e5d4-152a-44de-965e-0c23fe3ed54d_p2" x="18273.375" y="1323.0344"/> </glyph> <glyph class="process" orientation="vertical" id="pr_2a2c493f-b3b5-47f0-a2e2-f78f0808567c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16611981 Proteolytic degradation is very inefficient therefore more ful-length Gli2 present References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18171.0" y="1507.5269"/> <port id="pr_2a2c493f-b3b5-47f0-a2e2-f78f0808567c_p1" x="18176.0" y="1497.5269"/> <port id="pr_2a2c493f-b3b5-47f0-a2e2-f78f0808567c_p2" x="18176.0" y="1527.5269"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2531f352-2816-45be-828d-6af7c1bd5d75"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16611981 PMID:16651270 Gli2 ubi by bTrCP2 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18498.5" y="1186.0"/> <port id="pr_2531f352-2816-45be-828d-6af7c1bd5d75_p1" x="18518.5" y="1191.0"/> <port id="pr_2531f352-2816-45be-828d-6af7c1bd5d75_p2" x="18488.5" y="1191.0"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_165c9709-4cb5-4e68-a79b-80d889995937"> <bbox w="20.0" h="20.0" x="18630.25" y="1245.0"/> <port id="logicglyph_165c9709-4cb5-4e68-a79b-80d889995937_p1" x="18660.25" y="1255.0"/> <port id="logicglyph_165c9709-4cb5-4e68-a79b-80d889995937_p2" x="18620.25" y="1255.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_3eb5e192-53ca-4374-b3d3-629d840beb22"> <bbox w="10.0" h="10.0" x="18057.531" y="614.1632"/> <port id="pr_3eb5e192-53ca-4374-b3d3-629d840beb22_p1" x="18062.531" y="604.1632"/> <port id="pr_3eb5e192-53ca-4374-b3d3-629d840beb22_p2" x="18062.531" y="634.1632"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c1035c50-48b6-49a1-a147-27f5041cab27"> <bbox w="10.0" h="10.0" x="18892.25" y="1993.5"/> <port id="pr_c1035c50-48b6-49a1-a147-27f5041cab27_p1" x="18882.25" y="1998.5"/> <port id="pr_c1035c50-48b6-49a1-a147-27f5041cab27_p2" x="18912.25" y="1998.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_f831cd9f-162d-41fb-9a21-fee5a27a2e48"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18455992 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18374.945" y="1183.75"/> <port id="pr_f831cd9f-162d-41fb-9a21-fee5a27a2e48_p1" x="18379.945" y="1173.75"/> <port id="pr_f831cd9f-162d-41fb-9a21-fee5a27a2e48_p2" x="18379.945" y="1203.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d87ec747-3811-4b41-8457-a15db6c2196e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18455992 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18832.0" y="1783.0"/> <port id="pr_d87ec747-3811-4b41-8457-a15db6c2196e_p1" x="18822.0" y="1788.0"/> <port id="pr_d87ec747-3811-4b41-8457-a15db6c2196e_p2" x="18852.0" y="1788.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_30fe98c3-8cdb-4949-ba10-c95dd27c4ec3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18455992 PMID:16611981 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18984.125" y="1892.5"/> <port id="pr_30fe98c3-8cdb-4949-ba10-c95dd27c4ec3_p1" x="18989.125" y="1882.5"/> <port id="pr_30fe98c3-8cdb-4949-ba10-c95dd27c4ec3_p2" x="18989.125" y="1912.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6775f863-edfd-4876-988c-7be731ce4b1c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16611981 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18834.312" y="2002.0"/> <port id="pr_6775f863-edfd-4876-988c-7be731ce4b1c_p1" x="18854.312" y="2007.0"/> <port id="pr_6775f863-edfd-4876-988c-7be731ce4b1c_p2" x="18824.312" y="2007.0"/> </glyph> <glyph class="and" orientation="vertical" id="logicglyph_5e7ee1ae-bcce-4235-8745-127bad15bdeb"> <bbox w="20.0" h="20.0" x="18714.5" y="1448.0"/> <port id="logicglyph_5e7ee1ae-bcce-4235-8745-127bad15bdeb_p1" x="18724.5" y="1438.0"/> <port id="logicglyph_5e7ee1ae-bcce-4235-8745-127bad15bdeb_p2" x="18724.5" y="1478.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_f3e1b1dd-f79e-4e2d-9748-e09276b027c9"> <bbox w="10.0" h="10.0" x="18318.902" y="1915.5269"/> <port id="pr_f3e1b1dd-f79e-4e2d-9748-e09276b027c9_p1" x="18323.902" y="1935.5269"/> <port id="pr_f3e1b1dd-f79e-4e2d-9748-e09276b027c9_p2" x="18323.902" y="1905.5269"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_e41b410c-96f1-4fdb-a747-4e359be92129"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18455992 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18922.75" y="2189.0"/> <port id="pr_e41b410c-96f1-4fdb-a747-4e359be92129_p1" x="18912.75" y="2194.0"/> <port id="pr_e41b410c-96f1-4fdb-a747-4e359be92129_p2" x="18942.75" y="2194.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_8f209eed-3e48-4766-b999-cd330026d83e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20711444 PTM=sumoylation N/A in CellDesigner. Sumoylation not detected on endogenous Gli proteins. PKA antagonise sumoylation due to the consequence of PKA phosphorylation on Gli proteins it is not a direct effect of PKA. Exact References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19682.666" y="866.334"/> <port id="pr_8f209eed-3e48-4766-b999-cd330026d83e_p1" x="19687.666" y="856.334"/> <port id="pr_8f209eed-3e48-4766-b999-cd330026d83e_p2" x="19687.666" y="886.334"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_fe5a9169-157a-41d5-88a6-d61a33179bb0"> <bbox w="20.0" h="20.0" x="19981.5" y="859.5"/> <port id="logicglyph_fe5a9169-157a-41d5-88a6-d61a33179bb0_p1" x="20011.5" y="869.5"/> <port id="logicglyph_fe5a9169-157a-41d5-88a6-d61a33179bb0_p2" x="19971.5" y="869.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a280c2e9-7200-435c-ab49-d22a3eae08dc"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20711444 PTM=sumoylation N/A in CellDesigner. Sumoylation not detected on endogenous Gli proteins References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19947.25" y="867.334"/> <port id="pr_a280c2e9-7200-435c-ab49-d22a3eae08dc_p1" x="19952.25" y="857.334"/> <port id="pr_a280c2e9-7200-435c-ab49-d22a3eae08dc_p2" x="19952.25" y="887.334"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_b250bede-15dc-4162-a1f8-bb8538838816"> <bbox w="20.0" h="20.0" x="20050.5" y="861.0"/> <port id="logicglyph_b250bede-15dc-4162-a1f8-bb8538838816_p1" x="20080.5" y="871.0"/> <port id="logicglyph_b250bede-15dc-4162-a1f8-bb8538838816_p2" x="20040.5" y="871.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_4ffae97b-0f41-4e77-878a-43a3558d5c52"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:10050855 PMID:16571352 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19963.0" y="165.95001"/> <port id="pr_4ffae97b-0f41-4e77-878a-43a3558d5c52_p1" x="19968.0" y="185.95001"/> <port id="pr_4ffae97b-0f41-4e77-878a-43a3558d5c52_p2" x="19968.0" y="155.95001"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_0d4c3c09-b449-4b0a-83bd-3aba72ae526e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18477453 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="20190.0" y="173.54411"/> <port id="pr_0d4c3c09-b449-4b0a-83bd-3aba72ae526e_p1" x="20180.0" y="178.54411"/> <port id="pr_0d4c3c09-b449-4b0a-83bd-3aba72ae526e_p2" x="20210.0" y="178.54411"/> </glyph> <glyph class="process" orientation="vertical" id="pr_4d1f724d-6239-4793-be82-bc656f82d8c7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18477453 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="20262.25" y="1092.25"/> <port id="pr_4d1f724d-6239-4793-be82-bc656f82d8c7_p1" x="20267.25" y="1082.25"/> <port id="pr_4d1f724d-6239-4793-be82-bc656f82d8c7_p2" x="20267.25" y="1112.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_9a01eae0-6149-4575-855a-fdf6d653d246"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11331587 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19367.328" y="229.5"/> <port id="pr_9a01eae0-6149-4575-855a-fdf6d653d246_p1" x="19372.328" y="249.5"/> <port id="pr_9a01eae0-6149-4575-855a-fdf6d653d246_p2" x="19372.328" y="219.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5877f74d-ed66-4ad4-8800-0d04e390553f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: The association of CyclinB and PTC occurs when cell is in G2/M arrest References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19215.0" y="342.90985"/> <port id="pr_5877f74d-ed66-4ad4-8800-0d04e390553f_p1" x="19205.0" y="347.90985"/> <port id="pr_5877f74d-ed66-4ad4-8800-0d04e390553f_p2" x="19235.0" y="347.90985"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c87e4333-21a2-44c2-bdde-b66d4d18ca18"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11331587 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19364.5" y="197.58975"/> <port id="pr_c87e4333-21a2-44c2-bdde-b66d4d18ca18_p1" x="19384.5" y="202.58975"/> <port id="pr_c87e4333-21a2-44c2-bdde-b66d4d18ca18_p2" x="19354.5" y="202.58975"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_e69a7686-852e-4342-a7eb-0a7f3e377eb9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11331587 PMID:16489008 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19385.25" y="1916.0"/> <port id="pr_e69a7686-852e-4342-a7eb-0a7f3e377eb9_p1" x="19375.25" y="1921.0"/> <port id="pr_e69a7686-852e-4342-a7eb-0a7f3e377eb9_p2" x="19405.25" y="1921.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_08ace704-ec2b-46a4-8d70-9d15b56a312c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11331587 PMID:16489008 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19299.25" y="1135.0"/> <port id="pr_08ace704-ec2b-46a4-8d70-9d15b56a312c_p1" x="19304.25" y="1125.0"/> <port id="pr_08ace704-ec2b-46a4-8d70-9d15b56a312c_p2" x="19304.25" y="1155.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5d2c6ca2-d9ee-4e3d-a397-396413997261"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20818436 PMID:17115028 PMID:17312394 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19020.25" y="2424.0"/> <port id="pr_5d2c6ca2-d9ee-4e3d-a397-396413997261_p1" x="19010.25" y="2429.0"/> <port id="pr_5d2c6ca2-d9ee-4e3d-a397-396413997261_p2" x="19040.25" y="2429.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ab664bfc-c274-43ca-9112-d50e90ded6d4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: References-begin: PMID:20818436 PMID:17115028 PMID:17312394 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19291.375" y="2353.0"/> <port id="pr_ab664bfc-c274-43ca-9112-d50e90ded6d4_p1" x="19296.375" y="2343.0"/> <port id="pr_ab664bfc-c274-43ca-9112-d50e90ded6d4_p2" x="19296.375" y="2373.0"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_38642b0f-7995-4c0c-882b-4f18933e89b3"> <bbox w="20.0" h="20.0" x="19181.5" y="2341.25"/> <port id="logicglyph_38642b0f-7995-4c0c-882b-4f18933e89b3_p1" x="19171.5" y="2351.25"/> <port id="logicglyph_38642b0f-7995-4c0c-882b-4f18933e89b3_p2" x="19211.5" y="2351.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_fbe53401-96f1-487f-a2b4-0de202f62c9c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18997815 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18037.25" y="1363.0"/> <port id="pr_fbe53401-96f1-487f-a2b4-0de202f62c9c_p1" x="18042.25" y="1353.0"/> <port id="pr_fbe53401-96f1-487f-a2b4-0de202f62c9c_p2" x="18042.25" y="1383.0"/> </glyph> <glyph class="and" orientation="vertical" id="logicglyph_597a554d-7f77-40bb-baa3-a48765cdbb92"> <bbox w="20.0" h="20.0" x="18167.5" y="1190.75"/> <port id="logicglyph_597a554d-7f77-40bb-baa3-a48765cdbb92_p1" x="18177.5" y="1180.75"/> <port id="logicglyph_597a554d-7f77-40bb-baa3-a48765cdbb92_p2" x="18177.5" y="1220.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_bb282f58-a3cb-4171-a9fe-4e5152513097"> <bbox w="10.0" h="10.0" x="19291.5" y="2211.5"/> <port id="pr_bb282f58-a3cb-4171-a9fe-4e5152513097_p1" x="19296.5" y="2231.5"/> <port id="pr_bb282f58-a3cb-4171-a9fe-4e5152513097_p2" x="19296.5" y="2201.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9bc572a1-a3d3-46cd-bc40-ab8a0f8c6419"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:10559945 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19408.75" y="2255.6523"/> <port id="pr_9bc572a1-a3d3-46cd-bc40-ab8a0f8c6419_p1" x="19398.75" y="2260.6523"/> <port id="pr_9bc572a1-a3d3-46cd-bc40-ab8a0f8c6419_p2" x="19428.75" y="2260.6523"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ae04e48e-8012-4d92-b9c7-88d1fdbbc7b8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19403.25" y="2299.9153"/> <port id="pr_ae04e48e-8012-4d92-b9c7-88d1fdbbc7b8_p1" x="19423.25" y="2304.9153"/> <port id="pr_ae04e48e-8012-4d92-b9c7-88d1fdbbc7b8_p2" x="19393.25" y="2304.9153"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_4524e0c9-b66e-402c-94ac-d50bc78286d2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18829525 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19551.5" y="2279.0"/> <port id="pr_4524e0c9-b66e-402c-94ac-d50bc78286d2_p1" x="19541.5" y="2284.0"/> <port id="pr_4524e0c9-b66e-402c-94ac-d50bc78286d2_p2" x="19571.5" y="2284.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_364f21cf-482a-4942-83bc-f906b6f22fbc"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18829525 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19519.562" y="2455.0"/> <port id="pr_364f21cf-482a-4942-83bc-f906b6f22fbc_p1" x="19524.562" y="2475.0"/> <port id="pr_364f21cf-482a-4942-83bc-f906b6f22fbc_p2" x="19524.562" y="2445.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_16b7d880-e6af-4139-9482-cde2cb85574d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19575820 PMID:17052453 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18889.0" y="785.0"/> <port id="pr_16b7d880-e6af-4139-9482-cde2cb85574d_p1" x="18879.0" y="790.0"/> <port id="pr_16b7d880-e6af-4139-9482-cde2cb85574d_p2" x="18909.0" y="790.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_3a24f09b-48fa-4dfd-b949-7871006952b3"> <bbox w="10.0" h="10.0" x="18820.0" y="689.0"/> <port id="pr_3a24f09b-48fa-4dfd-b949-7871006952b3_p1" x="18810.0" y="694.0"/> <port id="pr_3a24f09b-48fa-4dfd-b949-7871006952b3_p2" x="18840.0" y="694.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_e43b63cc-e3d7-49a0-a1ff-c83a3dc88b89"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17688959 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18107.25" y="179.0"/> <port id="pr_e43b63cc-e3d7-49a0-a1ff-c83a3dc88b89_p1" x="18097.25" y="184.0"/> <port id="pr_e43b63cc-e3d7-49a0-a1ff-c83a3dc88b89_p2" x="18127.25" y="184.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c296338e-2b20-4504-939b-94583aa19190"> <bbox w="10.0" h="10.0" x="18380.033" y="456.5"/> <port id="pr_c296338e-2b20-4504-939b-94583aa19190_p1" x="18400.033" y="461.5"/> <port id="pr_c296338e-2b20-4504-939b-94583aa19190_p2" x="18370.033" y="461.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_41ded531-331d-4681-825c-5ed9d7114e8e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20889716 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19518.5" y="1569.0"/> <port id="pr_41ded531-331d-4681-825c-5ed9d7114e8e_p1" x="19538.5" y="1574.0"/> <port id="pr_41ded531-331d-4681-825c-5ed9d7114e8e_p2" x="19508.5" y="1574.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_62bed115-22a8-41ab-9608-9d3622c64dab"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19664.75" y="1112.0"/> <port id="pr_62bed115-22a8-41ab-9608-9d3622c64dab_p1" x="19669.75" y="1102.0"/> <port id="pr_62bed115-22a8-41ab-9608-9d3622c64dab_p2" x="19669.75" y="1132.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_3dcea67b-9f59-40c5-80bf-c24cf106c745"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20889716 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19572.75" y="1112.0"/> <port id="pr_3dcea67b-9f59-40c5-80bf-c24cf106c745_p1" x="19577.75" y="1132.0"/> <port id="pr_3dcea67b-9f59-40c5-80bf-c24cf106c745_p2" x="19577.75" y="1102.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_2f15a9a4-f8a0-438f-a6ee-a847f5ad4c22"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16647304 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19353.5" y="207.875"/> <port id="pr_2f15a9a4-f8a0-438f-a6ee-a847f5ad4c22_p1" x="19373.5" y="212.875"/> <port id="pr_2f15a9a4-f8a0-438f-a6ee-a847f5ad4c22_p2" x="19343.5" y="212.875"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_77a5f3bf-d915-4730-a660-6bee248a4f7b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17848687 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19401.0" y="228.625"/> <port id="pr_77a5f3bf-d915-4730-a660-6bee248a4f7b_p1" x="19421.0" y="233.625"/> <port id="pr_77a5f3bf-d915-4730-a660-6bee248a4f7b_p2" x="19391.0" y="233.625"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_a434b0f3-22a7-44bf-8a9b-f56d890501ca"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16647304 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19447.5" y="228.25"/> <port id="pr_a434b0f3-22a7-44bf-8a9b-f56d890501ca_p1" x="19467.5" y="233.25"/> <port id="pr_a434b0f3-22a7-44bf-8a9b-f56d890501ca_p2" x="19437.5" y="233.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_bfcb33c8-1c99-42d4-9d0d-7071c353660a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:12764189 PMID:18815277 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18499.438" y="546.7388"/> <port id="pr_bfcb33c8-1c99-42d4-9d0d-7071c353660a_p1" x="18489.438" y="551.7388"/> <port id="pr_bfcb33c8-1c99-42d4-9d0d-7071c353660a_p2" x="18519.438" y="551.7388"/> </glyph> <glyph class="process" orientation="vertical" id="pr_0076cecd-3efd-45ec-8e62-eb6ca2b0b745"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20360384 PMID:16740475 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="20004.875" y="3189.5"/> <port id="pr_0076cecd-3efd-45ec-8e62-eb6ca2b0b745_p1" x="20009.875" y="3179.5"/> <port id="pr_0076cecd-3efd-45ec-8e62-eb6ca2b0b745_p2" x="20009.875" y="3209.5"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_04731d10-ae18-4380-8add-f3cb46a2c495"> <bbox w="20.0" h="20.0" x="19856.25" y="3246.25"/> <port id="logicglyph_04731d10-ae18-4380-8add-f3cb46a2c495_p1" x="19846.25" y="3256.25"/> <port id="logicglyph_04731d10-ae18-4380-8add-f3cb46a2c495_p2" x="19886.25" y="3256.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_defea2b7-007b-4676-851e-b646c3b9ca4b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:12435627 PMID:19032343 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18403.25" y="3167.127"/> <port id="pr_defea2b7-007b-4676-851e-b646c3b9ca4b_p1" x="18393.25" y="3172.127"/> <port id="pr_defea2b7-007b-4676-851e-b646c3b9ca4b_p2" x="18423.25" y="3172.127"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_c6271bd1-7c2e-483e-bc7a-46a54fc0cfec"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20562908 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18793.5" y="3041.0"/> <port id="pr_c6271bd1-7c2e-483e-bc7a-46a54fc0cfec_p1" x="18783.5" y="3046.0"/> <port id="pr_c6271bd1-7c2e-483e-bc7a-46a54fc0cfec_p2" x="18813.5" y="3046.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_b9a82f4f-4bee-4405-b013-bf761eb83ea9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19736394 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19028.5" y="3025.8018"/> <port id="pr_b9a82f4f-4bee-4405-b013-bf761eb83ea9_p1" x="19018.5" y="3030.8018"/> <port id="pr_b9a82f4f-4bee-4405-b013-bf761eb83ea9_p2" x="19048.5" y="3030.8018"/> </glyph> <glyph class="process" orientation="vertical" id="pr_14dba99a-e124-462a-9b83-4c31d56c7093"> <bbox w="10.0" h="10.0" x="19172.0" y="3045.5"/> <port id="pr_14dba99a-e124-462a-9b83-4c31d56c7093_p1" x="19177.0" y="3035.5"/> <port id="pr_14dba99a-e124-462a-9b83-4c31d56c7093_p2" x="19177.0" y="3065.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_6a271784-4e61-41bf-9d13-b454e849fc0c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:12138125 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18310.188" y="3412.0"/> <port id="pr_6a271784-4e61-41bf-9d13-b454e849fc0c_p1" x="18315.188" y="3432.0"/> <port id="pr_6a271784-4e61-41bf-9d13-b454e849fc0c_p2" x="18315.188" y="3402.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_8ac65c06-cb6c-4ffd-a06d-216090702a62"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:12138125 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18372.0" y="3577.5"/> <port id="pr_8ac65c06-cb6c-4ffd-a06d-216090702a62_p1" x="18377.0" y="3567.5"/> <port id="pr_8ac65c06-cb6c-4ffd-a06d-216090702a62_p2" x="18377.0" y="3597.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_e7c96d87-44b9-419b-bff7-0130c8a629f6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:12138125 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18228.75" y="3705.0"/> <port id="pr_e7c96d87-44b9-419b-bff7-0130c8a629f6_p1" x="18248.75" y="3710.0"/> <port id="pr_e7c96d87-44b9-419b-bff7-0130c8a629f6_p2" x="18218.75" y="3710.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_9929247c-6813-468e-a4b1-cdc7db483632"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:12138125 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18085.258" y="3590.5156"/> <port id="pr_9929247c-6813-468e-a4b1-cdc7db483632_p1" x="18090.258" y="3610.5156"/> <port id="pr_9929247c-6813-468e-a4b1-cdc7db483632_p2" x="18090.258" y="3580.5156"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a8d3ab4d-4c80-4ba7-9af2-a32b4e35fa8b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:12138125 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18427.5" y="3306.0"/> <port id="pr_a8d3ab4d-4c80-4ba7-9af2-a32b4e35fa8b_p1" x="18417.5" y="3311.0"/> <port id="pr_a8d3ab4d-4c80-4ba7-9af2-a32b4e35fa8b_p2" x="18447.5" y="3311.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c70de91a-8496-4b28-a13b-f7be77e318df"> <bbox w="10.0" h="10.0" x="18166.062" y="3463.0"/> <port id="pr_c70de91a-8496-4b28-a13b-f7be77e318df_p1" x="18156.062" y="3468.0"/> <port id="pr_c70de91a-8496-4b28-a13b-f7be77e318df_p2" x="18186.062" y="3468.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_77ac5163-643c-4188-a95c-97aefd42aaf8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16293631 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18022.125" y="3388.0"/> <port id="pr_77ac5163-643c-4188-a95c-97aefd42aaf8_p1" x="18027.125" y="3408.0"/> <port id="pr_77ac5163-643c-4188-a95c-97aefd42aaf8_p2" x="18027.125" y="3378.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_cb4731f5-06d3-4ec9-aa89-022cc0d722eb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17035233 PMID:16328026 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18793.5" y="3086.0"/> <port id="pr_cb4731f5-06d3-4ec9-aa89-022cc0d722eb_p1" x="18783.5" y="3091.0"/> <port id="pr_cb4731f5-06d3-4ec9-aa89-022cc0d722eb_p2" x="18813.5" y="3091.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_585c7cc4-a4ff-49c7-b711-3429c796d5a3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16328026 PMID:17035233 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19028.5" y="3111.9268"/> <port id="pr_585c7cc4-a4ff-49c7-b711-3429c796d5a3_p1" x="19018.5" y="3116.9268"/> <port id="pr_585c7cc4-a4ff-49c7-b711-3429c796d5a3_p2" x="19048.5" y="3116.9268"/> </glyph> <glyph class="process" orientation="vertical" id="pr_d7c2657c-f269-453d-974b-3159e744b854"> <bbox w="10.0" h="10.0" x="19476.488" y="3181.75"/> <port id="pr_d7c2657c-f269-453d-974b-3159e744b854_p1" x="19481.488" y="3171.75"/> <port id="pr_d7c2657c-f269-453d-974b-3159e744b854_p2" x="19481.488" y="3201.75"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_5721ab0b-316a-404b-8473-5c2679686acd"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19049965 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18793.5" y="3178.0"/> <port id="pr_5721ab0b-316a-404b-8473-5c2679686acd_p1" x="18783.5" y="3183.0"/> <port id="pr_5721ab0b-316a-404b-8473-5c2679686acd_p2" x="18813.5" y="3183.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_3fb9deed-ec0f-4ada-a0a3-2aa8d42b4e6c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19049965 PMID:11493558 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18793.5" y="3132.0"/> <port id="pr_3fb9deed-ec0f-4ada-a0a3-2aa8d42b4e6c_p1" x="18783.5" y="3137.0"/> <port id="pr_3fb9deed-ec0f-4ada-a0a3-2aa8d42b4e6c_p2" x="18813.5" y="3137.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_dd534be1-7fb8-4022-8ffb-e5e0d073b0e8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20145151 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19028.5" y="3169.102"/> <port id="pr_dd534be1-7fb8-4022-8ffb-e5e0d073b0e8_p1" x="19018.5" y="3174.102"/> <port id="pr_dd534be1-7fb8-4022-8ffb-e5e0d073b0e8_p2" x="19048.5" y="3174.102"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_17fcf11f-0c70-44f7-90d7-bfcd07c19854"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18813803 PMID:16880536 PMID:19190345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18793.5" y="3224.0"/> <port id="pr_17fcf11f-0c70-44f7-90d7-bfcd07c19854_p1" x="18783.5" y="3229.0"/> <port id="pr_17fcf11f-0c70-44f7-90d7-bfcd07c19854_p2" x="18813.5" y="3229.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_cd348cee-932a-4ddd-9a52-b79fd575ce04"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19424602 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19028.5" y="3188.2388"/> <port id="pr_cd348cee-932a-4ddd-9a52-b79fd575ce04_p1" x="19018.5" y="3193.2388"/> <port id="pr_cd348cee-932a-4ddd-9a52-b79fd575ce04_p2" x="19048.5" y="3193.2388"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_3ffff867-b419-4712-8d86-0a8bb2aa363e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19029.785" y="3225.005"/> <port id="pr_3ffff867-b419-4712-8d86-0a8bb2aa363e_p1" x="19019.785" y="3230.005"/> <port id="pr_3ffff867-b419-4712-8d86-0a8bb2aa363e_p2" x="19049.785" y="3230.005"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_fc51d563-79bd-4007-a686-bd032dcf7ca4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18813803 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18793.5" y="3272.0"/> <port id="pr_fc51d563-79bd-4007-a686-bd032dcf7ca4_p1" x="18783.5" y="3277.0"/> <port id="pr_fc51d563-79bd-4007-a686-bd032dcf7ca4_p2" x="18813.5" y="3277.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_12a16bae-bbc3-420f-bc95-68815c0c8a2f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:18813803 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19033.295" y="3212.417"/> <port id="pr_12a16bae-bbc3-420f-bc95-68815c0c8a2f_p1" x="19023.295" y="3217.417"/> <port id="pr_12a16bae-bbc3-420f-bc95-68815c0c8a2f_p2" x="19053.295" y="3217.417"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ef21a96d-f408-4fb6-b2f6-fe1e8529fd07"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18539112 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19028.5" y="3246.5203"/> <port id="pr_ef21a96d-f408-4fb6-b2f6-fe1e8529fd07_p1" x="19018.5" y="3251.5203"/> <port id="pr_ef21a96d-f408-4fb6-b2f6-fe1e8529fd07_p2" x="19048.5" y="3251.5203"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_4d05b5b3-d0ca-46e5-b3fb-f2c90a3c5723"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18813803 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18794.5" y="3407.5654"/> <port id="pr_4d05b5b3-d0ca-46e5-b3fb-f2c90a3c5723_p1" x="18784.5" y="3412.5654"/> <port id="pr_4d05b5b3-d0ca-46e5-b3fb-f2c90a3c5723_p2" x="18814.5" y="3412.5654"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_ceaaa377-bec4-42e2-963b-21aae0efc1f3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20678582 PMID:21034673 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19033.49" y="3348.9778"/> <port id="pr_ceaaa377-bec4-42e2-963b-21aae0efc1f3_p1" x="19023.49" y="3353.9778"/> <port id="pr_ceaaa377-bec4-42e2-963b-21aae0efc1f3_p2" x="19053.49" y="3353.9778"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_79cccc99-38ee-4489-966b-e53dd9ba275c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19424602 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19028.5" y="3162.8018"/> <port id="pr_79cccc99-38ee-4489-966b-e53dd9ba275c_p1" x="19018.5" y="3167.8018"/> <port id="pr_79cccc99-38ee-4489-966b-e53dd9ba275c_p2" x="19048.5" y="3167.8018"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9a424a26-f971-4dcd-8e58-63a1ecd1efcb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19424602 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19028.5" y="3137.3643"/> <port id="pr_9a424a26-f971-4dcd-8e58-63a1ecd1efcb_p1" x="19018.5" y="3142.3643"/> <port id="pr_9a424a26-f971-4dcd-8e58-63a1ecd1efcb_p2" x="19048.5" y="3142.3643"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_3939a690-1ab0-4a59-8257-7b9c67a8cbd0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18813803 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18794.5" y="3453.0"/> <port id="pr_3939a690-1ab0-4a59-8257-7b9c67a8cbd0_p1" x="18784.5" y="3458.0"/> <port id="pr_3939a690-1ab0-4a59-8257-7b9c67a8cbd0_p2" x="18814.5" y="3458.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a54623af-1a1f-4b76-84cf-f88976da710f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:21285253 PMID:21346143 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19040.854" y="3335.7456"/> <port id="pr_a54623af-1a1f-4b76-84cf-f88976da710f_p1" x="19030.854" y="3340.7456"/> <port id="pr_a54623af-1a1f-4b76-84cf-f88976da710f_p2" x="19060.854" y="3340.7456"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_a241f06c-aab3-40d8-a890-2fc29f3a3a6d"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18813803 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18794.5" y="3500.0"/> <port id="pr_a241f06c-aab3-40d8-a890-2fc29f3a3a6d_p1" x="18784.5" y="3505.0"/> <port id="pr_a241f06c-aab3-40d8-a890-2fc29f3a3a6d_p2" x="18814.5" y="3505.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_1b9ceaa8-50b9-4785-9c40-fbbb685a1cc1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20946121 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19035.426" y="3427.272"/> <port id="pr_1b9ceaa8-50b9-4785-9c40-fbbb685a1cc1_p1" x="19025.426" y="3432.272"/> <port id="pr_1b9ceaa8-50b9-4785-9c40-fbbb685a1cc1_p2" x="19055.426" y="3432.272"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_be6d1820-c91a-48e8-8c65-bf3edd03f080"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16880536 PMID:18813803 PMID:19190345 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18794.5" y="3543.0"/> <port id="pr_be6d1820-c91a-48e8-8c65-bf3edd03f080_p1" x="18784.5" y="3548.0"/> <port id="pr_be6d1820-c91a-48e8-8c65-bf3edd03f080_p2" x="18814.5" y="3548.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_cf669126-88b7-4831-81f3-332c8fad4566"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19398556 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19033.426" y="3481.2837"/> <port id="pr_cf669126-88b7-4831-81f3-332c8fad4566_p1" x="19023.426" y="3486.2837"/> <port id="pr_cf669126-88b7-4831-81f3-332c8fad4566_p2" x="19053.426" y="3486.2837"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_fa6376fb-4cc0-4aa7-b720-54d754bd0d09"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:15140221 PMID:18813803 PMID:18698484 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18793.5" y="3320.0"/> <port id="pr_fa6376fb-4cc0-4aa7-b720-54d754bd0d09_p1" x="18783.5" y="3325.0"/> <port id="pr_fa6376fb-4cc0-4aa7-b720-54d754bd0d09_p2" x="18813.5" y="3325.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_bd9b448e-3ba3-4154-87f1-2742f16d68b2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:19424602 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19037.441" y="3235.2612"/> <port id="pr_bd9b448e-3ba3-4154-87f1-2742f16d68b2_p1" x="19027.441" y="3240.2612"/> <port id="pr_bd9b448e-3ba3-4154-87f1-2742f16d68b2_p2" x="19057.441" y="3240.2612"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_1c1091a4-8dea-4994-92ea-63f49837e189"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20712011 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18793.5" y="3366.0"/> <port id="pr_1c1091a4-8dea-4994-92ea-63f49837e189_p1" x="18783.5" y="3371.0"/> <port id="pr_1c1091a4-8dea-4994-92ea-63f49837e189_p2" x="18813.5" y="3371.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_3983bca4-18b5-44f9-9652-92ff0d8c04e7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20712011 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19028.5" y="3328.451"/> <port id="pr_3983bca4-18b5-44f9-9652-92ff0d8c04e7_p1" x="19018.5" y="3333.451"/> <port id="pr_3983bca4-18b5-44f9-9652-92ff0d8c04e7_p2" x="19048.5" y="3333.451"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_ed225e70-e6d7-4cc5-bcd3-40cb73407cd1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16396903 PMID:20107231 PMID:16054035 PMID:16406505 PMID:16880536 PMID:17000779 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18794.5" y="3813.0"/> <port id="pr_ed225e70-e6d7-4cc5-bcd3-40cb73407cd1_p1" x="18784.5" y="3818.0"/> <port id="pr_ed225e70-e6d7-4cc5-bcd3-40cb73407cd1_p2" x="18814.5" y="3818.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_b37917f4-209d-42f0-82c1-dba836d58c56"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:9609833 PMID:16413481 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18794.5" y="3594.0"/> <port id="pr_b37917f4-209d-42f0-82c1-dba836d58c56_p1" x="18784.5" y="3599.0"/> <port id="pr_b37917f4-209d-42f0-82c1-dba836d58c56_p2" x="18814.5" y="3599.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_00629119-cc70-4930-8532-1f542a9c6623"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20348948 PMID:19960541 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19041.715" y="3439.25"/> <port id="pr_00629119-cc70-4930-8532-1f542a9c6623_p1" x="19046.715" y="3459.25"/> <port id="pr_00629119-cc70-4930-8532-1f542a9c6623_p2" x="19046.715" y="3429.25"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_fc788cec-4f68-4b24-9e5b-4701337d1463"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:15087129 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18794.5" y="3642.0"/> <port id="pr_fc788cec-4f68-4b24-9e5b-4701337d1463_p1" x="18784.5" y="3647.0"/> <port id="pr_fc788cec-4f68-4b24-9e5b-4701337d1463_p2" x="18814.5" y="3647.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ca0901ab-8a5f-4192-9afd-7cd73258a186"> <bbox w="10.0" h="10.0" x="19800.254" y="3317.1401"/> <port id="pr_ca0901ab-8a5f-4192-9afd-7cd73258a186_p1" x="19805.254" y="3307.1401"/> <port id="pr_ca0901ab-8a5f-4192-9afd-7cd73258a186_p2" x="19805.254" y="3337.1401"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_3a50749e-5657-461a-b808-d63376260265"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20143239 PMID:16413481 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18794.5" y="3682.0"/> <port id="pr_3a50749e-5657-461a-b808-d63376260265_p1" x="18784.5" y="3687.0"/> <port id="pr_3a50749e-5657-461a-b808-d63376260265_p2" x="18814.5" y="3687.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_54cf600b-00a0-4d52-99d2-2e2c984fc914"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19055944 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19041.941" y="3483.25"/> <port id="pr_54cf600b-00a0-4d52-99d2-2e2c984fc914_p1" x="19046.941" y="3503.25"/> <port id="pr_54cf600b-00a0-4d52-99d2-2e2c984fc914_p2" x="19046.941" y="3473.25"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_22f9a157-79f2-4086-8952-ca8c8613bfc4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:9216996 PMID:16413481 PMID:17000779 ANNOTATION: it was shown that Med12 binds to Gli1 promoter References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18794.5" y="3725.0"/> <port id="pr_22f9a157-79f2-4086-8952-ca8c8613bfc4_p1" x="18784.5" y="3730.0"/> <port id="pr_22f9a157-79f2-4086-8952-ca8c8613bfc4_p2" x="18814.5" y="3730.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_fa135382-5def-44f9-9c8a-6dafb9c88aba"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16396903 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18794.5" y="3767.0"/> <port id="pr_fa135382-5def-44f9-9c8a-6dafb9c88aba_p1" x="18784.5" y="3772.0"/> <port id="pr_fa135382-5def-44f9-9c8a-6dafb9c88aba_p2" x="18814.5" y="3772.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_00e4552d-14ae-4835-ac7b-8685d7cae2a2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21059263 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18794.5" y="3858.0"/> <port id="pr_00e4552d-14ae-4835-ac7b-8685d7cae2a2_p1" x="18784.5" y="3863.0"/> <port id="pr_00e4552d-14ae-4835-ac7b-8685d7cae2a2_p2" x="18814.5" y="3863.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_66fc2ac7-3e30-475f-b807-35f60f8fbd5b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19651775 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19041.123" y="3603.75"/> <port id="pr_66fc2ac7-3e30-475f-b807-35f60f8fbd5b_p1" x="19046.123" y="3623.75"/> <port id="pr_66fc2ac7-3e30-475f-b807-35f60f8fbd5b_p2" x="19046.123" y="3593.75"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_e684bd6f-3151-450a-83cd-d6e98b5498eb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21059263 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18794.5" y="3939.0"/> <port id="pr_e684bd6f-3151-450a-83cd-d6e98b5498eb_p1" x="18784.5" y="3944.0"/> <port id="pr_e684bd6f-3151-450a-83cd-d6e98b5498eb_p2" x="18814.5" y="3944.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_30bc61c4-9547-47b8-909f-fc22a66b0d03"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19581346 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19042.258" y="3611.75"/> <port id="pr_30bc61c4-9547-47b8-909f-fc22a66b0d03_p1" x="19047.258" y="3631.75"/> <port id="pr_30bc61c4-9547-47b8-909f-fc22a66b0d03_p2" x="19047.258" y="3601.75"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_f02bc800-3687-49e0-a5d4-5bd9c1731b58"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19736394 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18794.5" y="3979.0"/> <port id="pr_f02bc800-3687-49e0-a5d4-5bd9c1731b58_p1" x="18784.5" y="3984.0"/> <port id="pr_f02bc800-3687-49e0-a5d4-5bd9c1731b58_p2" x="18814.5" y="3984.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_57864db1-a469-4b72-85f4-cba8e1f6a144"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:15520176 PMID:14555646 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18794.5" y="4023.0"/> <port id="pr_57864db1-a469-4b72-85f4-cba8e1f6a144_p1" x="18784.5" y="4028.0"/> <port id="pr_57864db1-a469-4b72-85f4-cba8e1f6a144_p2" x="18814.5" y="4028.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_cbe3b30f-89be-4b12-a7b1-82b1d632f211"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19736394 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19042.287" y="3631.75"/> <port id="pr_cbe3b30f-89be-4b12-a7b1-82b1d632f211_p1" x="19047.287" y="3651.75"/> <port id="pr_cbe3b30f-89be-4b12-a7b1-82b1d632f211_p2" x="19047.287" y="3621.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_eeabdae2-2aaa-413a-86a6-9937cd5596c2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19736394 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19041.166" y="3749.75"/> <port id="pr_eeabdae2-2aaa-413a-86a6-9937cd5596c2_p1" x="19046.166" y="3769.75"/> <port id="pr_eeabdae2-2aaa-413a-86a6-9937cd5596c2_p2" x="19046.166" y="3739.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_2f791b08-d7a1-4958-9378-1084bb238ca6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19996099 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18438.562" y="3511.0"/> <port id="pr_2f791b08-d7a1-4958-9378-1084bb238ca6_p1" x="18428.562" y="3516.0"/> <port id="pr_2f791b08-d7a1-4958-9378-1084bb238ca6_p2" x="18458.562" y="3516.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_37bbeab5-77ef-4039-b190-b930f27e6573"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19996099 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18514.0" y="3626.0"/> <port id="pr_37bbeab5-77ef-4039-b190-b930f27e6573_p1" x="18519.0" y="3616.0"/> <port id="pr_37bbeab5-77ef-4039-b190-b930f27e6573_p2" x="18519.0" y="3646.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5bb3e7d5-ed23-486f-90cb-72c51488fd88"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19996099 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19481.438" y="3112.62"/> <port id="pr_5bb3e7d5-ed23-486f-90cb-72c51488fd88_p1" x="19471.438" y="3117.62"/> <port id="pr_5bb3e7d5-ed23-486f-90cb-72c51488fd88_p2" x="19501.438" y="3117.62"/> </glyph> <glyph class="process" orientation="vertical" id="pr_7bd44eb4-9972-4ecb-a33a-5daf916a2850"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19996099 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19959.312" y="3264.3574"/> <port id="pr_7bd44eb4-9972-4ecb-a33a-5daf916a2850_p1" x="19964.312" y="3254.3574"/> <port id="pr_7bd44eb4-9972-4ecb-a33a-5daf916a2850_p2" x="19964.312" y="3284.3574"/> </glyph> <glyph class="process" orientation="vertical" id="pr_2f3ce3ad-edd5-4ea9-82db-e4afa1a32bc6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19996099 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19775.332" y="3738.7292"/> <port id="pr_2f3ce3ad-edd5-4ea9-82db-e4afa1a32bc6_p1" x="19780.332" y="3728.7292"/> <port id="pr_2f3ce3ad-edd5-4ea9-82db-e4afa1a32bc6_p2" x="19780.332" y="3758.7292"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d2f5e71e-4661-49db-b700-b146093ae2ed"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19996099 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19979.5" y="3746.489"/> <port id="pr_d2f5e71e-4661-49db-b700-b146093ae2ed_p1" x="19969.5" y="3751.489"/> <port id="pr_d2f5e71e-4661-49db-b700-b146093ae2ed_p2" x="19999.5" y="3751.489"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ebf43d24-9089-4b78-a675-0c298f842877"> <bbox w="10.0" h="10.0" x="18289.875" y="3677.75"/> <port id="pr_ebf43d24-9089-4b78-a675-0c298f842877_p1" x="18294.875" y="3667.75"/> <port id="pr_ebf43d24-9089-4b78-a675-0c298f842877_p2" x="18294.875" y="3697.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_2ecafbbc-3f16-42d6-bc5a-371c463d5def"> <bbox w="10.0" h="10.0" x="18329.875" y="3677.75"/> <port id="pr_2ecafbbc-3f16-42d6-bc5a-371c463d5def_p1" x="18334.875" y="3697.75"/> <port id="pr_2ecafbbc-3f16-42d6-bc5a-371c463d5def_p2" x="18334.875" y="3667.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_fe8fb01b-fed7-4b89-ad5b-bc6a8546cd28"> <bbox w="10.0" h="10.0" x="18540.75" y="3936.9985"/> <port id="pr_fe8fb01b-fed7-4b89-ad5b-bc6a8546cd28_p1" x="18545.75" y="3926.9985"/> <port id="pr_fe8fb01b-fed7-4b89-ad5b-bc6a8546cd28_p2" x="18545.75" y="3956.9985"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_35447194-2c1c-43ae-a985-5ac04d3e9277"> <bbox w="20.0" h="20.0" x="18476.334" y="3937.0"/> <port id="logicglyph_35447194-2c1c-43ae-a985-5ac04d3e9277_p1" x="18466.334" y="3947.0"/> <port id="logicglyph_35447194-2c1c-43ae-a985-5ac04d3e9277_p2" x="18506.334" y="3947.0"/> </glyph> <glyph class="or" orientation="horizontal" id="logicglyph_1a25e3f4-9c59-4cd4-840b-ef9a60f8a60c"> <bbox w="20.0" h="20.0" x="18410.5" y="4026.25"/> <port id="logicglyph_1a25e3f4-9c59-4cd4-840b-ef9a60f8a60c_p1" x="18400.5" y="4036.25"/> <port id="logicglyph_1a25e3f4-9c59-4cd4-840b-ef9a60f8a60c_p2" x="18440.5" y="4036.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ccd988c1-c3df-4fa7-8dd8-27b79e20fb59"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20081843 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19329.625" y="3109.34"/> <port id="pr_ccd988c1-c3df-4fa7-8dd8-27b79e20fb59_p1" x="19334.625" y="3099.34"/> <port id="pr_ccd988c1-c3df-4fa7-8dd8-27b79e20fb59_p2" x="19334.625" y="3129.34"/> </glyph> <glyph class="process" orientation="vertical" id="pr_7fbd4b08-90dc-49e8-894c-e19b60ee7842"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20081843 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19370.875" y="3109.34"/> <port id="pr_7fbd4b08-90dc-49e8-894c-e19b60ee7842_p1" x="19375.875" y="3129.34"/> <port id="pr_7fbd4b08-90dc-49e8-894c-e19b60ee7842_p2" x="19375.875" y="3099.34"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_9e014253-19c0-4e54-8474-5b81dca59c45"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16571352 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18800.0" y="4065.722"/> <port id="pr_9e014253-19c0-4e54-8474-5b81dca59c45_p1" x="18790.0" y="4070.722"/> <port id="pr_9e014253-19c0-4e54-8474-5b81dca59c45_p2" x="18820.0" y="4070.722"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_bebdb41f-0bdd-4bc3-b187-39f39497b11b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16054035 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18794.5" y="4107.0"/> <port id="pr_bebdb41f-0bdd-4bc3-b187-39f39497b11b_p1" x="18784.5" y="4112.0"/> <port id="pr_bebdb41f-0bdd-4bc3-b187-39f39497b11b_p2" x="18814.5" y="4112.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_7ec0575b-865d-438c-8adc-9225ee0ac34e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16054035 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19042.36" y="3695.75"/> <port id="pr_7ec0575b-865d-438c-8adc-9225ee0ac34e_p1" x="19047.36" y="3715.75"/> <port id="pr_7ec0575b-865d-438c-8adc-9225ee0ac34e_p2" x="19047.36" y="3685.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_0eeb9b4c-99be-4840-9a18-12a4e665d7ee"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19574535 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19042.14" y="3548.75"/> <port id="pr_0eeb9b4c-99be-4840-9a18-12a4e665d7ee_p1" x="19047.14" y="3568.75"/> <port id="pr_0eeb9b4c-99be-4840-9a18-12a4e665d7ee_p2" x="19047.14" y="3538.75"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_3603d869-fc6e-4bed-8bc1-2839f8c00950"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16158046 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18794.5" y="4149.0"/> <port id="pr_3603d869-fc6e-4bed-8bc1-2839f8c00950_p1" x="18784.5" y="4154.0"/> <port id="pr_3603d869-fc6e-4bed-8bc1-2839f8c00950_p2" x="18814.5" y="4154.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_0999d5c4-adb8-4923-910a-dd9e3b9feef4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16158046 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19042.402" y="3683.25"/> <port id="pr_0999d5c4-adb8-4923-910a-dd9e3b9feef4_p1" x="19047.402" y="3703.25"/> <port id="pr_0999d5c4-adb8-4923-910a-dd9e3b9feef4_p2" x="19047.402" y="3673.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f390c60b-631e-4bdd-8e26-c876ab1069b5"> <bbox w="10.0" h="10.0" x="18197.25" y="4343.0"/> <port id="pr_f390c60b-631e-4bdd-8e26-c876ab1069b5_p1" x="18187.25" y="4348.0"/> <port id="pr_f390c60b-631e-4bdd-8e26-c876ab1069b5_p2" x="18217.25" y="4348.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_5f2974ef-96d4-408f-9ba0-502c3c2044cc"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11960000 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18490.514" y="4435.5"/> <port id="pr_5f2974ef-96d4-408f-9ba0-502c3c2044cc_p1" x="18495.514" y="4425.5"/> <port id="pr_5f2974ef-96d4-408f-9ba0-502c3c2044cc_p2" x="18495.514" y="4455.5"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_0ee0b8b1-0404-40b0-bbd2-b7bba54a371c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19219074 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18794.5" y="4188.0"/> <port id="pr_0ee0b8b1-0404-40b0-bbd2-b7bba54a371c_p1" x="18784.5" y="4193.0"/> <port id="pr_0ee0b8b1-0404-40b0-bbd2-b7bba54a371c_p2" x="18814.5" y="4193.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9c1e5fdc-8120-472a-9ae2-1f1df120d2b5"> <bbox w="10.0" h="10.0" x="18208.762" y="2941.5"/> <port id="pr_9c1e5fdc-8120-472a-9ae2-1f1df120d2b5_p1" x="18198.762" y="2946.5"/> <port id="pr_9c1e5fdc-8120-472a-9ae2-1f1df120d2b5_p2" x="18228.762" y="2946.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_e88ac042-687e-4ef4-9af6-58d8161a8afb"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19219074 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18418.375" y="3015.0"/> <port id="pr_e88ac042-687e-4ef4-9af6-58d8161a8afb_p1" x="18408.375" y="3020.0"/> <port id="pr_e88ac042-687e-4ef4-9af6-58d8161a8afb_p2" x="18438.375" y="3020.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c1dead5c-a3d5-4d72-801a-852cb7d36dd8"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16977332 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19042.395" y="3736.25"/> <port id="pr_c1dead5c-a3d5-4d72-801a-852cb7d36dd8_p1" x="19047.395" y="3756.25"/> <port id="pr_c1dead5c-a3d5-4d72-801a-852cb7d36dd8_p2" x="19047.395" y="3726.25"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_07b32288-b72e-45a0-9701-39b82f54f443"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19190345 PMID:16880536 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18794.5" y="4224.0"/> <port id="pr_07b32288-b72e-45a0-9701-39b82f54f443_p1" x="18784.5" y="4229.0"/> <port id="pr_07b32288-b72e-45a0-9701-39b82f54f443_p2" x="18814.5" y="4229.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c0b6e1c2-032a-4a55-920f-a0657e9a97f6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: Maps_Modules_end Identifiers_end References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19041.281" y="3882.25"/> <port id="pr_c0b6e1c2-032a-4a55-920f-a0657e9a97f6_p1" x="19046.281" y="3902.25"/> <port id="pr_c0b6e1c2-032a-4a55-920f-a0657e9a97f6_p2" x="19046.281" y="3872.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_e9efaf54-afb4-41ed-9833-c19f59d613d4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:12606705 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19041.236" y="3913.25"/> <port id="pr_e9efaf54-afb4-41ed-9833-c19f59d613d4_p1" x="19046.236" y="3933.25"/> <port id="pr_e9efaf54-afb4-41ed-9833-c19f59d613d4_p2" x="19046.236" y="3903.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_35bd7a65-a313-4720-998f-7dc862393628"> <bbox w="10.0" h="10.0" x="18537.75" y="4202.5186"/> <port id="pr_35bd7a65-a313-4720-998f-7dc862393628_p1" x="18527.75" y="4207.5186"/> <port id="pr_35bd7a65-a313-4720-998f-7dc862393628_p2" x="18557.75" y="4207.5186"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_3595e939-4a9c-479b-ba89-3f82f67b0d27"> <bbox w="10.0" h="10.0" x="18468.438" y="4312.6694"/> <port id="pr_3595e939-4a9c-479b-ba89-3f82f67b0d27_p1" x="18458.438" y="4317.6694"/> <port id="pr_3595e939-4a9c-479b-ba89-3f82f67b0d27_p2" x="18488.438" y="4317.6694"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_32865b81-3107-4ec1-89f8-3824d20187ab"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19190345 PMID:16880536 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18794.5" y="4261.0"/> <port id="pr_32865b81-3107-4ec1-89f8-3824d20187ab_p1" x="18784.5" y="4266.0"/> <port id="pr_32865b81-3107-4ec1-89f8-3824d20187ab_p2" x="18814.5" y="4266.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_bf58b5bc-c510-452b-9362-9f50be2bfb05"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21228116 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19041.266" y="3931.75"/> <port id="pr_bf58b5bc-c510-452b-9362-9f50be2bfb05_p1" x="19046.266" y="3951.75"/> <port id="pr_bf58b5bc-c510-452b-9362-9f50be2bfb05_p2" x="19046.266" y="3921.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_59971b74-aa37-4898-bbdd-b0a792bcfd56"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:21228116 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19041.307" y="3900.75"/> <port id="pr_59971b74-aa37-4898-bbdd-b0a792bcfd56_p1" x="19046.307" y="3920.75"/> <port id="pr_59971b74-aa37-4898-bbdd-b0a792bcfd56_p2" x="19046.307" y="3890.75"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_7498586a-0451-4ede-851e-8e319cb96682"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16880536 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18794.5" y="4295.0"/> <port id="pr_7498586a-0451-4ede-851e-8e319cb96682_p1" x="18784.5" y="4300.0"/> <port id="pr_7498586a-0451-4ede-851e-8e319cb96682_p2" x="18814.5" y="4300.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_564cb5d3-1488-4376-9e5b-5d02e5da8ba1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:15994944 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19041.191" y="4009.25"/> <port id="pr_564cb5d3-1488-4376-9e5b-5d02e5da8ba1_p1" x="19046.191" y="4029.25"/> <port id="pr_564cb5d3-1488-4376-9e5b-5d02e5da8ba1_p2" x="19046.191" y="3999.25"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_b469cdeb-15de-4f82-85b2-f7296bbd5c5c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19190345 PMID:16880536 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18794.5" y="4329.0"/> <port id="pr_b469cdeb-15de-4f82-85b2-f7296bbd5c5c_p1" x="18784.5" y="4334.0"/> <port id="pr_b469cdeb-15de-4f82-85b2-f7296bbd5c5c_p2" x="18814.5" y="4334.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_01f414e2-24f8-4ae3-b0ae-c9fc4cbdd80e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17466953 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19041.176" y="4050.25"/> <port id="pr_01f414e2-24f8-4ae3-b0ae-c9fc4cbdd80e_p1" x="19046.176" y="4070.25"/> <port id="pr_01f414e2-24f8-4ae3-b0ae-c9fc4cbdd80e_p2" x="19046.176" y="4040.25"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_d8fb312d-167f-442d-b7e6-930ff566ba73"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19190345 PMID:16880536 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18794.5" y="4364.0"/> <port id="pr_d8fb312d-167f-442d-b7e6-930ff566ba73_p1" x="18784.5" y="4369.0"/> <port id="pr_d8fb312d-167f-442d-b7e6-930ff566ba73_p2" x="18814.5" y="4369.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ee5a4ed0-5a15-448b-b9ac-992b38a1a34c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19211835 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19041.152" y="4097.25"/> <port id="pr_ee5a4ed0-5a15-448b-b9ac-992b38a1a34c_p1" x="19046.152" y="4117.25"/> <port id="pr_ee5a4ed0-5a15-448b-b9ac-992b38a1a34c_p2" x="19046.152" y="4087.25"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_5ac63c08-8413-4d3b-bec1-528b4e4fd7a1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18057099 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18794.5" y="4399.0"/> <port id="pr_5ac63c08-8413-4d3b-bec1-528b4e4fd7a1_p1" x="18784.5" y="4404.0"/> <port id="pr_5ac63c08-8413-4d3b-bec1-528b4e4fd7a1_p2" x="18814.5" y="4404.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_97899350-a41b-485b-b650-7f81aecd1578"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21442356 Not sure if direct interaction of gli1 with gene References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18794.5" y="4433.0"/> <port id="pr_97899350-a41b-485b-b650-7f81aecd1578_p1" x="18784.5" y="4438.0"/> <port id="pr_97899350-a41b-485b-b650-7f81aecd1578_p2" x="18814.5" y="4438.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_277cbb57-57d3-4cea-8d28-7f995aca0686"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21442356 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19042.484" y="3825.25"/> <port id="pr_277cbb57-57d3-4cea-8d28-7f995aca0686_p1" x="19047.484" y="3845.25"/> <port id="pr_277cbb57-57d3-4cea-8d28-7f995aca0686_p2" x="19047.484" y="3815.25"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_c9fd73d1-cd84-4cad-909d-46e358208c04"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19809516 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18794.5" y="4471.0"/> <port id="pr_c9fd73d1-cd84-4cad-909d-46e358208c04_p1" x="18784.5" y="4476.0"/> <port id="pr_c9fd73d1-cd84-4cad-909d-46e358208c04_p2" x="18814.5" y="4476.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_a0cec72f-1a32-4317-bc42-b4ebd9463dbf"> <bbox w="10.0" h="10.0" x="19042.508" y="3808.75"/> <port id="pr_a0cec72f-1a32-4317-bc42-b4ebd9463dbf_p1" x="19047.508" y="3828.75"/> <port id="pr_a0cec72f-1a32-4317-bc42-b4ebd9463dbf_p2" x="19047.508" y="3798.75"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_db05e29e-bc52-4311-9601-66b67f3eb21a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16169709 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18794.5" y="3899.0"/> <port id="pr_db05e29e-bc52-4311-9601-66b67f3eb21a_p1" x="18784.5" y="3904.0"/> <port id="pr_db05e29e-bc52-4311-9601-66b67f3eb21a_p2" x="18814.5" y="3904.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c0c077e4-30bf-45a9-8d91-aaa4bc48b501"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18979497 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19040.996" y="3687.75"/> <port id="pr_c0c077e4-30bf-45a9-8d91-aaa4bc48b501_p1" x="19045.996" y="3707.75"/> <port id="pr_c0c077e4-30bf-45a9-8d91-aaa4bc48b501_p2" x="19045.996" y="3677.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_1e7d33ce-b26a-49bd-9fa7-cf245ab22c9e"> <bbox w="10.0" h="10.0" x="19141.25" y="4293.7847"/> <port id="pr_1e7d33ce-b26a-49bd-9fa7-cf245ab22c9e_p1" x="19161.25" y="4298.7847"/> <port id="pr_1e7d33ce-b26a-49bd-9fa7-cf245ab22c9e_p2" x="19131.25" y="4298.7847"/> </glyph> <glyph class="process" orientation="vertical" id="pr_8296cd0d-3997-4cab-9663-dac852ab434d"> <bbox w="10.0" h="10.0" x="19131.291" y="4400.0"/> <port id="pr_8296cd0d-3997-4cab-9663-dac852ab434d_p1" x="19136.291" y="4390.0"/> <port id="pr_8296cd0d-3997-4cab-9663-dac852ab434d_p2" x="19136.291" y="4420.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_cce4136c-040b-415c-ae81-61738d07f529"> <bbox w="10.0" h="10.0" x="19887.0" y="4010.25"/> <port id="pr_cce4136c-040b-415c-ae81-61738d07f529_p1" x="19892.0" y="4000.25"/> <port id="pr_cce4136c-040b-415c-ae81-61738d07f529_p2" x="19892.0" y="4030.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_cbb13cce-344c-473d-aa5a-8761865551ba"> <bbox w="10.0" h="10.0" x="20029.0" y="4010.25"/> <port id="pr_cbb13cce-344c-473d-aa5a-8761865551ba_p1" x="20034.0" y="4000.25"/> <port id="pr_cbb13cce-344c-473d-aa5a-8761865551ba_p2" x="20034.0" y="4030.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_214e5705-9da8-45f6-bfa1-69a612eb2fa7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18379348 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19643.996" y="3513.25"/> <port id="pr_214e5705-9da8-45f6-bfa1-69a612eb2fa7_p1" x="19663.996" y="3518.25"/> <port id="pr_214e5705-9da8-45f6-bfa1-69a612eb2fa7_p2" x="19633.996" y="3518.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_7126fe72-0edc-4e14-bbe7-c8022264ed70"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20463034 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19489.375" y="3061.34"/> <port id="pr_7126fe72-0edc-4e14-bbe7-c8022264ed70_p1" x="19479.375" y="3066.34"/> <port id="pr_7126fe72-0edc-4e14-bbe7-c8022264ed70_p2" x="19509.375" y="3066.34"/> </glyph> <glyph class="and" orientation="horizontal" id="logicglyph_077f9b36-590c-4f89-8e84-714cd393a395"> <bbox w="20.0" h="20.0" x="19667.0" y="3241.75"/> <port id="logicglyph_077f9b36-590c-4f89-8e84-714cd393a395_p1" x="19697.0" y="3251.75"/> <port id="logicglyph_077f9b36-590c-4f89-8e84-714cd393a395_p2" x="19657.0" y="3251.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_b38378e0-5b8c-4a90-a598-d8014f275969"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17000779 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19385.465" y="3671.75"/> <port id="pr_b38378e0-5b8c-4a90-a598-d8014f275969_p1" x="19390.465" y="3661.75"/> <port id="pr_b38378e0-5b8c-4a90-a598-d8014f275969_p2" x="19390.465" y="3691.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_82cccb67-eeed-4acf-bba9-f4209ecf8db9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17297467 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18925.5" y="3488.5"/> <port id="pr_82cccb67-eeed-4acf-bba9-f4209ecf8db9_p1" x="18930.5" y="3478.5"/> <port id="pr_82cccb67-eeed-4acf-bba9-f4209ecf8db9_p2" x="18930.5" y="3508.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_739cf038-db7f-40cf-a91a-413a16c0eda2"> <bbox w="10.0" h="10.0" x="18193.688" y="4242.0"/> <port id="pr_739cf038-db7f-40cf-a91a-413a16c0eda2_p1" x="18183.688" y="4247.0"/> <port id="pr_739cf038-db7f-40cf-a91a-413a16c0eda2_p2" x="18213.688" y="4247.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_eb478e8c-d43f-4cd0-9d23-ea79c85c7abc"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20564213 ANNOTATION: Not clear how suprresion is regulated by Hedgehog References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18795.0" y="4609.0"/> <port id="pr_eb478e8c-d43f-4cd0-9d23-ea79c85c7abc_p1" x="18785.0" y="4614.0"/> <port id="pr_eb478e8c-d43f-4cd0-9d23-ea79c85c7abc_p2" x="18815.0" y="4614.0"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_c2503add-a375-446c-b421-6dd8a337a03e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19351822 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18795.0" y="4653.0"/> <port id="pr_c2503add-a375-446c-b421-6dd8a337a03e_p1" x="18785.0" y="4658.0"/> <port id="pr_c2503add-a375-446c-b421-6dd8a337a03e_p2" x="18815.0" y="4658.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9b219236-458e-41bb-88a5-a705fb12db89"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21359530 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19668.5" y="4099.5254"/> <port id="pr_9b219236-458e-41bb-88a5-a705fb12db89_p1" x="19658.5" y="4104.5254"/> <port id="pr_9b219236-458e-41bb-88a5-a705fb12db89_p2" x="19688.5" y="4104.5254"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_8c209c94-2fb8-480e-94f9-d44770ec8298"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21245165 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19673.5" y="4225.3794"/> <port id="pr_8c209c94-2fb8-480e-94f9-d44770ec8298_p1" x="19663.5" y="4230.3794"/> <port id="pr_8c209c94-2fb8-480e-94f9-d44770ec8298_p2" x="19693.5" y="4230.3794"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c89facb9-6c26-4afe-96b8-6eaf8ad19796"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21245165 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19754.0" y="4236.4414"/> <port id="pr_c89facb9-6c26-4afe-96b8-6eaf8ad19796_p1" x="19744.0" y="4241.4414"/> <port id="pr_c89facb9-6c26-4afe-96b8-6eaf8ad19796_p2" x="19774.0" y="4241.4414"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_80b1155d-7ba4-42f4-9fcb-8c30862bd647"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21245165 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19823.0" y="4256.956"/> <port id="pr_80b1155d-7ba4-42f4-9fcb-8c30862bd647_p1" x="19813.0" y="4261.956"/> <port id="pr_80b1155d-7ba4-42f4-9fcb-8c30862bd647_p2" x="19843.0" y="4261.956"/> </glyph> <glyph class="process" orientation="vertical" id="pr_305e9da7-9599-4135-ab4f-dc399c0ce0a3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21245165 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19677.96" y="4366.0"/> <port id="pr_305e9da7-9599-4135-ab4f-dc399c0ce0a3_p1" x="19682.96" y="4356.0"/> <port id="pr_305e9da7-9599-4135-ab4f-dc399c0ce0a3_p2" x="19682.96" y="4386.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_3504923d-fadb-4719-a447-3d4c62d1a560"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21245165 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19755.5" y="4405.7935"/> <port id="pr_3504923d-fadb-4719-a447-3d4c62d1a560_p1" x="19745.5" y="4410.7935"/> <port id="pr_3504923d-fadb-4719-a447-3d4c62d1a560_p2" x="19775.5" y="4410.7935"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_d713f6de-2e9f-4c58-94ad-5de6d4a4cbaa"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20851997 PMID:19351822 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19169.5" y="4587.956"/> <port id="pr_d713f6de-2e9f-4c58-94ad-5de6d4a4cbaa_p1" x="19159.5" y="4592.956"/> <port id="pr_d713f6de-2e9f-4c58-94ad-5de6d4a4cbaa_p2" x="19189.5" y="4592.956"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_78787fb8-149f-4afa-b4a1-a954454bc20a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20851997 PMID:19351822 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19169.5" y="4604.4717"/> <port id="pr_78787fb8-149f-4afa-b4a1-a954454bc20a_p1" x="19159.5" y="4609.4717"/> <port id="pr_78787fb8-149f-4afa-b4a1-a954454bc20a_p2" x="19189.5" y="4609.4717"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_6aec4a6a-bd13-4287-a44e-da7ffb0d7002"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20851997 PMID:19351822 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19169.5" y="4620.9863"/> <port id="pr_6aec4a6a-bd13-4287-a44e-da7ffb0d7002_p1" x="19159.5" y="4625.9863"/> <port id="pr_6aec4a6a-bd13-4287-a44e-da7ffb0d7002_p2" x="19189.5" y="4625.9863"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_482d1a53-1550-45f2-8c2e-96b6052037c1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20851997 PMID:19351822 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19169.5" y="4637.502"/> <port id="pr_482d1a53-1550-45f2-8c2e-96b6052037c1_p1" x="19159.5" y="4642.502"/> <port id="pr_482d1a53-1550-45f2-8c2e-96b6052037c1_p2" x="19189.5" y="4642.502"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_14aded83-025e-47cd-8c2d-74d8b5694e85"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20851997 PMID:19351822 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19169.5" y="4654.017"/> <port id="pr_14aded83-025e-47cd-8c2d-74d8b5694e85_p1" x="19159.5" y="4659.017"/> <port id="pr_14aded83-025e-47cd-8c2d-74d8b5694e85_p2" x="19189.5" y="4659.017"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_346754b9-3c38-47da-aad4-1729147a7eb7"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:20851997 PMID:19351822 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19169.5" y="4670.532"/> <port id="pr_346754b9-3c38-47da-aad4-1729147a7eb7_p1" x="19159.5" y="4675.532"/> <port id="pr_346754b9-3c38-47da-aad4-1729147a7eb7_p2" x="19189.5" y="4675.532"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_e34591b1-e771-4699-88b6-67dd12c29b26"> <bbox w="10.0" h="10.0" x="18999.0" y="4133.9717"/> <port id="pr_e34591b1-e771-4699-88b6-67dd12c29b26_p1" x="18989.0" y="4138.9717"/> <port id="pr_e34591b1-e771-4699-88b6-67dd12c29b26_p2" x="19019.0" y="4138.9717"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_a75e1010-834d-4dee-93ed-886036bce118"> <bbox w="10.0" h="10.0" x="19001.25" y="4707.9326"/> <port id="pr_a75e1010-834d-4dee-93ed-886036bce118_p1" x="18991.25" y="4712.9326"/> <port id="pr_a75e1010-834d-4dee-93ed-886036bce118_p2" x="19021.25" y="4712.9326"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_eb9c7747-8f52-4ca1-b4f7-f8d7c1a9d715"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19351822 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19169.5" y="4571.4414"/> <port id="pr_eb9c7747-8f52-4ca1-b4f7-f8d7c1a9d715_p1" x="19159.5" y="4576.4414"/> <port id="pr_eb9c7747-8f52-4ca1-b4f7-f8d7c1a9d715_p2" x="19189.5" y="4576.4414"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5d1f28cb-53b3-47a2-9c7e-8a94182a8cf6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:15944709 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19898.25" y="4375.292"/> <port id="pr_5d1f28cb-53b3-47a2-9c7e-8a94182a8cf6_p1" x="19888.25" y="4380.292"/> <port id="pr_5d1f28cb-53b3-47a2-9c7e-8a94182a8cf6_p2" x="19918.25" y="4380.292"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_13d1cb77-7dad-4398-827f-09acd1ec9102"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID18493594 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19672.5" y="4510.1797"/> <port id="pr_13d1cb77-7dad-4398-827f-09acd1ec9102_p1" x="19662.5" y="4515.1797"/> <port id="pr_13d1cb77-7dad-4398-827f-09acd1ec9102_p2" x="19692.5" y="4515.1797"/> </glyph> <glyph class="process" orientation="vertical" id="pr_47a901ad-b5f1-4bb4-af06-45dd1da63412"> <bbox w="10.0" h="10.0" x="19391.281" y="4070.75"/> <port id="pr_47a901ad-b5f1-4bb4-af06-45dd1da63412_p1" x="19396.281" y="4090.75"/> <port id="pr_47a901ad-b5f1-4bb4-af06-45dd1da63412_p2" x="19396.281" y="4060.75"/> </glyph> <glyph class="process" orientation="vertical" id="pr_634e426b-bf41-4646-b7a8-f1f328b6f2ac"> <bbox w="10.0" h="10.0" x="19391.469" y="4052.75"/> <port id="pr_634e426b-bf41-4646-b7a8-f1f328b6f2ac_p1" x="19396.469" y="4072.75"/> <port id="pr_634e426b-bf41-4646-b7a8-f1f328b6f2ac_p2" x="19396.469" y="4042.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5a529b96-19d9-4e79-a617-24d2f3c5ba4c"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16878133 PMID:18550634 Not known which miRNA of the miR-17-92 polycistron is reponsible for degradation of Tsp1 and CTGF not known which miRNA is responsible therefor miR-17-3p is shown in complex References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19751.0" y="4498.0"/> <port id="pr_5a529b96-19d9-4e79-a617-24d2f3c5ba4c_p1" x="19741.0" y="4503.0"/> <port id="pr_5a529b96-19d9-4e79-a617-24d2f3c5ba4c_p2" x="19771.0" y="4503.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_689ca8f0-3a90-4b84-9e85-1708dd393712"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18700987 The miR-17-5p drives the cell from G1 to S phase thereby regulating more than 20 genes References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19239.383" y="3912.0"/> <port id="pr_689ca8f0-3a90-4b84-9e85-1708dd393712_p1" x="19244.383" y="3932.0"/> <port id="pr_689ca8f0-3a90-4b84-9e85-1708dd393712_p2" x="19244.383" y="3902.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_305b3b2b-fc40-47a8-a931-5cad5e89d1ad"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21383238 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19756.0" y="4536.0967"/> <port id="pr_305b3b2b-fc40-47a8-a931-5cad5e89d1ad_p1" x="19746.0" y="4541.0967"/> <port id="pr_305b3b2b-fc40-47a8-a931-5cad5e89d1ad_p2" x="19776.0" y="4541.0967"/> </glyph> <glyph class="process" orientation="vertical" id="pr_ac9b15e4-6def-4034-9c73-f402054efe90"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:21383238 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19671.49" y="4647.75"/> <port id="pr_ac9b15e4-6def-4034-9c73-f402054efe90_p1" x="19676.49" y="4637.75"/> <port id="pr_ac9b15e4-6def-4034-9c73-f402054efe90_p2" x="19676.49" y="4667.75"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_9e7a91c8-9395-4c72-98f3-08ed75048192"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18695042 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19770.5" y="4635.3555"/> <port id="pr_9e7a91c8-9395-4c72-98f3-08ed75048192_p1" x="19760.5" y="4640.3555"/> <port id="pr_9e7a91c8-9395-4c72-98f3-08ed75048192_p2" x="19790.5" y="4640.3555"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_011f1e98-aca5-4ef0-8ad7-ea73a6f3afb2"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18695042 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19725.5" y="4623.624"/> <port id="pr_011f1e98-aca5-4ef0-8ad7-ea73a6f3afb2_p1" x="19715.5" y="4628.624"/> <port id="pr_011f1e98-aca5-4ef0-8ad7-ea73a6f3afb2_p2" x="19745.5" y="4628.624"/> </glyph> <glyph class="process" orientation="vertical" id="pr_372fdf91-86df-42d4-aea8-341ef2b1397e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:21271217 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19882.32" y="4345.25"/> <port id="pr_372fdf91-86df-42d4-aea8-341ef2b1397e_p1" x="19887.32" y="4365.25"/> <port id="pr_372fdf91-86df-42d4-aea8-341ef2b1397e_p2" x="19887.32" y="4335.25"/> </glyph> <glyph class="process" orientation="vertical" id="pr_2a043391-0db5-4616-853a-fa4f7f008c9a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19684618 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="20034.6" y="4333.25"/> <port id="pr_2a043391-0db5-4616-853a-fa4f7f008c9a_p1" x="20039.6" y="4353.25"/> <port id="pr_2a043391-0db5-4616-853a-fa4f7f008c9a_p2" x="20039.6" y="4323.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_5f089ed4-f56e-4711-81cd-050936cf0702"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18460397 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19633.25" y="4091.0"/> <port id="pr_5f089ed4-f56e-4711-81cd-050936cf0702_p1" x="19623.25" y="4096.0"/> <port id="pr_5f089ed4-f56e-4711-81cd-050936cf0702_p2" x="19653.25" y="4096.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c383ed1e-d4d9-4005-8a89-fe7def6798b5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18077375 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19884.0" y="4513.5728"/> <port id="pr_c383ed1e-d4d9-4005-8a89-fe7def6798b5_p1" x="19874.0" y="4518.5728"/> <port id="pr_c383ed1e-d4d9-4005-8a89-fe7def6798b5_p2" x="19904.0" y="4518.5728"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_b90f09d7-3045-4023-9160-005859356332"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18077375 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19880.5" y="4585.171"/> <port id="pr_b90f09d7-3045-4023-9160-005859356332_p1" x="19870.5" y="4590.171"/> <port id="pr_b90f09d7-3045-4023-9160-005859356332_p2" x="19900.5" y="4590.171"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_cdde13bd-7e3e-479d-9672-540fe71f9ac0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10050855 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19037.133" y="3978.687"/> <port id="pr_cdde13bd-7e3e-479d-9672-540fe71f9ac0_p1" x="19027.133" y="3983.687"/> <port id="pr_cdde13bd-7e3e-479d-9672-540fe71f9ac0_p2" x="19057.133" y="3983.687"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_f90fa37e-0f98-469c-b624-10dc89223257"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:10021362 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19040.148" y="3762.9697"/> <port id="pr_f90fa37e-0f98-469c-b624-10dc89223257_p1" x="19030.148" y="3767.9697"/> <port id="pr_f90fa37e-0f98-469c-b624-10dc89223257_p2" x="19060.148" y="3767.9697"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_7f99bb79-35f9-46eb-b4c7-0af30bd9508a"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16434164 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19036.125" y="3802.4473"/> <port id="pr_7f99bb79-35f9-46eb-b4c7-0af30bd9508a_p1" x="19026.125" y="3807.4473"/> <port id="pr_7f99bb79-35f9-46eb-b4c7-0af30bd9508a_p2" x="19056.125" y="3807.4473"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_874ef7ca-84da-4c76-a242-f307439e54c5"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16434164 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19031.969" y="3822.4238"/> <port id="pr_874ef7ca-84da-4c76-a242-f307439e54c5_p1" x="19021.969" y="3827.4238"/> <port id="pr_874ef7ca-84da-4c76-a242-f307439e54c5_p2" x="19051.969" y="3827.4238"/> </glyph> <glyph class="process" orientation="vertical" id="pr_749ee755-f5ab-48f5-ae72-064c0b482a4f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>References_begin: PMID:16434164 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19041.123" y="4144.25"/> <port id="pr_749ee755-f5ab-48f5-ae72-064c0b482a4f_p1" x="19046.123" y="4164.25"/> <port id="pr_749ee755-f5ab-48f5-ae72-064c0b482a4f_p2" x="19046.123" y="4134.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_23977a41-6725-485a-9361-1ad3ebf6e130"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19464.324" y="4965.7754"/> <port id="pr_23977a41-6725-485a-9361-1ad3ebf6e130_p1" x="19484.324" y="4970.7754"/> <port id="pr_23977a41-6725-485a-9361-1ad3ebf6e130_p2" x="19454.324" y="4970.7754"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d01d05a2-c685-4ed9-a042-57da38f258de"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16885213 PMID:18815277 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19054.375" y="5070.586"/> <port id="pr_d01d05a2-c685-4ed9-a042-57da38f258de_p1" x="19074.375" y="5075.586"/> <port id="pr_d01d05a2-c685-4ed9-a042-57da38f258de_p2" x="19044.375" y="5075.586"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_b93e1f1d-7a92-424d-a1ad-1cd2a064fbc3"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:16885213 PMID:17430994 PMID:21474452 PMID:20081366 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18559.75" y="5002.7637"/> <port id="pr_b93e1f1d-7a92-424d-a1ad-1cd2a064fbc3_p1" x="18579.75" y="5007.7637"/> <port id="pr_b93e1f1d-7a92-424d-a1ad-1cd2a064fbc3_p2" x="18549.75" y="5007.7637"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_c083e9de-8457-4150-9d04-77a23204d79e"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17430994 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18168.0" y="5002.327"/> <port id="pr_c083e9de-8457-4150-9d04-77a23204d79e_p1" x="18188.0" y="5007.327"/> <port id="pr_c083e9de-8457-4150-9d04-77a23204d79e_p2" x="18158.0" y="5007.327"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_313e7707-5411-4756-8f16-3f876baa1a13"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:12764189 PMID:18815277 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18467.625" y="5398.957"/> <port id="pr_313e7707-5411-4756-8f16-3f876baa1a13_p1" x="18457.625" y="5403.957"/> <port id="pr_313e7707-5411-4756-8f16-3f876baa1a13_p2" x="18487.625" y="5403.957"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_3f59d7a6-88ef-4660-905c-3d790687e25f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:18815277 PMID:16885213 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18550.5" y="5236.0"/> <port id="pr_3f59d7a6-88ef-4660-905c-3d790687e25f_p1" x="18540.5" y="5241.0"/> <port id="pr_3f59d7a6-88ef-4660-905c-3d790687e25f_p2" x="18570.5" y="5241.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6b809c2e-f202-4353-9b25-3b32be7f7d35"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18731.25" y="5235.6396"/> <port id="pr_6b809c2e-f202-4353-9b25-3b32be7f7d35_p1" x="18721.25" y="5240.6396"/> <port id="pr_6b809c2e-f202-4353-9b25-3b32be7f7d35_p2" x="18751.25" y="5240.6396"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_744eae91-b45a-4a6c-8678-29614c41e3b0"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:12297047 PMID:16847462 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18442.5" y="5552.3506"/> <port id="pr_744eae91-b45a-4a6c-8678-29614c41e3b0_p1" x="18432.5" y="5557.3506"/> <port id="pr_744eae91-b45a-4a6c-8678-29614c41e3b0_p2" x="18462.5" y="5557.3506"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d6de48b8-dc45-4687-9157-a9e1c5520cb1"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="18792.0" y="5611.6855"/> <port id="pr_d6de48b8-dc45-4687-9157-a9e1c5520cb1_p1" x="18782.0" y="5616.6855"/> <port id="pr_d6de48b8-dc45-4687-9157-a9e1c5520cb1_p2" x="18812.0" y="5616.6855"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_44bba7c2-08b3-42c1-8f47-90f396484ab6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17549397 PMID:19082481 PMID:11801735 PMID:12514186 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19389.5" y="5429.5"/> <port id="pr_44bba7c2-08b3-42c1-8f47-90f396484ab6_p1" x="19379.5" y="5434.5"/> <port id="pr_44bba7c2-08b3-42c1-8f47-90f396484ab6_p2" x="19409.5" y="5434.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_082b59d3-afc7-4786-bf66-6fa14e5103d9"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:12514186 PMID:18359851 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19048.25" y="5428.0"/> <port id="pr_082b59d3-afc7-4786-bf66-6fa14e5103d9_p1" x="19038.25" y="5433.0"/> <port id="pr_082b59d3-afc7-4786-bf66-6fa14e5103d9_p2" x="19068.25" y="5433.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_6c4a9b18-f1da-46a3-b05d-dc20d5bf2f89"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:17549397 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19229.5" y="5428.0"/> <port id="pr_6c4a9b18-f1da-46a3-b05d-dc20d5bf2f89_p1" x="19219.5" y="5433.0"/> <port id="pr_6c4a9b18-f1da-46a3-b05d-dc20d5bf2f89_p2" x="19249.5" y="5433.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_00e118bb-5cfc-4e9b-b16f-b68c72c8becd"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11801735 PMID:19082481 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19551.5" y="5538.5"/> <port id="pr_00e118bb-5cfc-4e9b-b16f-b68c72c8becd_p1" x="19556.5" y="5528.5"/> <port id="pr_00e118bb-5cfc-4e9b-b16f-b68c72c8becd_p2" x="19556.5" y="5558.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_3d91d1d6-77ee-439e-9767-0e8e71fe8e9f"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19215.0" y="5646.8975"/> <port id="pr_3d91d1d6-77ee-439e-9767-0e8e71fe8e9f_p1" x="19235.0" y="5651.8975"/> <port id="pr_3d91d1d6-77ee-439e-9767-0e8e71fe8e9f_p2" x="19205.0" y="5651.8975"/> </glyph> <glyph class="omitted process" orientation="horizontal" id="pr_37e34648-d84c-4bc5-8519-02b2e491ecbd"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19435.588" y="5285.25"/> <port id="pr_37e34648-d84c-4bc5-8519-02b2e491ecbd_p1" x="19425.588" y="5290.25"/> <port id="pr_37e34648-d84c-4bc5-8519-02b2e491ecbd_p2" x="19455.588" y="5290.25"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_18ce24d3-0c52-48f3-ab87-e598e7fbfc6b"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="20010.0" y="4994.0"/> <port id="pr_18ce24d3-0c52-48f3-ab87-e598e7fbfc6b_p1" x="20000.0" y="4999.0"/> <port id="pr_18ce24d3-0c52-48f3-ab87-e598e7fbfc6b_p2" x="20030.0" y="4999.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_80cedba2-d5ee-4347-a66f-5154e91ba2aa"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:12829230 PMID:11955434 PMID:15967165 PMID:15611338 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="20115.0" y="5243.0"/> <port id="pr_80cedba2-d5ee-4347-a66f-5154e91ba2aa_p1" x="20105.0" y="5248.0"/> <port id="pr_80cedba2-d5ee-4347-a66f-5154e91ba2aa_p2" x="20135.0" y="5248.0"/> </glyph> <glyph class="or" orientation="vertical" id="logicglyph_7b7aada7-d30d-4bd2-820e-9739ccac78a3"> <bbox w="20.0" h="20.0" x="20098.0" y="5140.995"/> <port id="logicglyph_7b7aada7-d30d-4bd2-820e-9739ccac78a3_p1" x="20108.0" y="5130.995"/> <port id="logicglyph_7b7aada7-d30d-4bd2-820e-9739ccac78a3_p2" x="20108.0" y="5170.995"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_39e3a870-ea5b-4024-874b-b18b73cf62b4"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="20305.25" y="4994.0"/> <port id="pr_39e3a870-ea5b-4024-874b-b18b73cf62b4_p1" x="20325.25" y="4999.0"/> <port id="pr_39e3a870-ea5b-4024-874b-b18b73cf62b4_p2" x="20295.25" y="4999.0"/> </glyph> <glyph class="process" orientation="vertical" id="pr_c7b3db79-55a8-40b3-9101-dd2bc9c8acf6"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:11955434 :Activation of P-Rex can be synergistically by PIP3 and Gi-proteins References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="20340.5" y="5072.5"/> <port id="pr_c7b3db79-55a8-40b3-9101-dd2bc9c8acf6_p1" x="20345.5" y="5062.5"/> <port id="pr_c7b3db79-55a8-40b3-9101-dd2bc9c8acf6_p2" x="20345.5" y="5092.5"/> </glyph> <glyph class="process" orientation="vertical" id="pr_1422d72d-f63d-46e4-9fd0-8f970732d245"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:15901767 PMID:20595387 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="20231.41" y="5420.0"/> <port id="pr_1422d72d-f63d-46e4-9fd0-8f970732d245_p1" x="20236.41" y="5410.0"/> <port id="pr_1422d72d-f63d-46e4-9fd0-8f970732d245_p2" x="20236.41" y="5440.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_816af77c-d0c9-4146-8938-1ae195ecf885"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:15611338 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19908.0" y="5443.0"/> <port id="pr_816af77c-d0c9-4146-8938-1ae195ecf885_p1" x="19928.0" y="5448.0"/> <port id="pr_816af77c-d0c9-4146-8938-1ae195ecf885_p2" x="19898.0" y="5448.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_68f92fa3-b9a4-4b99-9789-085b7b739c91"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19373.5" y="5557.5"/> <port id="pr_68f92fa3-b9a4-4b99-9789-085b7b739c91_p1" x="19393.5" y="5562.5"/> <port id="pr_68f92fa3-b9a4-4b99-9789-085b7b739c91_p2" x="19363.5" y="5562.5"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_d88f74b1-0a1f-4438-8e06-b9408a213559"> <notes> <html xmlns="http://www.w3.org/1999/xhtml" xmlns:celldesigner="http://www.sbml.org/2001/ns/celldesigner" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"> <head> <title/> </head> <body>Maps_Modules_begin: MAP:survival / MODULE:HEDGEHOG Maps_Modules_end References_begin: PMID:19465923 References_end</body> </html> </notes> <bbox w="10.0" h="10.0" x="19671.75" y="4977.0"/> <port id="pr_d88f74b1-0a1f-4438-8e06-b9408a213559_p1" x="19661.75" y="4982.0"/> <port id="pr_d88f74b1-0a1f-4438-8e06-b9408a213559_p2" x="19691.75" y="4982.0"/> </glyph> <glyph class="process" orientation="horizontal" id="pr_1d04d210-6b94-4672-a379-f2dfa2351348"> <bbox w="10.0" h="10.0" x="18569.906" y="2048.8984"/> <port id="pr_1d04d210-6b94-4672-a379-f2dfa2351348_p1" x="18589.906" y="2053.8984"/> <port id="pr_1d04d210-6b94-4672-a379-f2dfa2351348_p2" x="18559.906" y="2053.8984"/> </glyph> <arc class="consumption" id="cons_49fa5c77-ee04-4274-b763-90dda8fbc2a3" source="gf1_s14_gf1_sa30" target="pr_b1547231-fce3-4274-9a58-fcbd5a2982d9_p1"> <start x="313.5" y="167.5"/> <next x="322.5" y="367.5"/> <end x="291.53998" y="417.0"/> </arc> <arc class="consumption" id="cons_06f15937-a61d-45d4-a10a-606395e3de09" source="gf1_s423_gf1_sa35" target="pr_b1547231-fce3-4274-9a58-fcbd5a2982d9_p1"> <start x="442.5" y="347.5"/> <next x="322.5" y="367.5"/> <end x="291.53998" y="417.0"/> </arc> <arc class="production" id="prod_384e1273-4742-4a07-b613-84b4d15eac86" source="pr_b1547231-fce3-4274-9a58-fcbd5a2982d9_p2" target="gf1_s417_gf1_csa8"> <start x="291.53998" y="447.0"/> <end x="262.5" y="492.5"/> </arc> <arc class="consumption" id="cons_8c4f436c-8ef2-4ee2-b48d-17fcb0fc74ab" source="gf1_s415_gf1_sa48" target="pr_c96f806b-0b5a-48d0-83ee-da3aeaaf3a0d_p1"> <start x="1502.5" y="457.5"/> <next x="1432.5" y="407.5"/> <end x="1365.5" y="476.3672"/> </arc> <arc class="consumption" id="cons_198b17b9-be9a-4418-92e3-18f1c46bbafc" source="gf1_s416_gf1_sa45" target="pr_c96f806b-0b5a-48d0-83ee-da3aeaaf3a0d_p1"> <start x="1562.5" y="347.5"/> <next x="1432.5" y="407.5"/> <end x="1365.5" y="476.3672"/> </arc> <arc class="production" id="prod_d1e526bc-9653-4429-a217-8bd6cc033057" source="pr_c96f806b-0b5a-48d0-83ee-da3aeaaf3a0d_p2" target="gf1_s419_gf1_csa10"> <start x="1335.5" y="476.3672"/> <end x="1272.5" y="541.875"/> </arc> <arc class="catalysis" id="modif_35d58745-369b-48da-b1aa-fa0cb7a96367" source="gf1_s102_gf1_sa46" target="pr_c96f806b-0b5a-48d0-83ee-da3aeaaf3a0d"> <start x="1512.3535" y="167.5"/> <end x="1353.7156" y="480.196"/> </arc> <arc class="catalysis" id="modif_591d4a9b-2fee-4122-a552-f9f7e354cf5d" source="gf1_s4506_gf1_sa44" target="pr_c96f806b-0b5a-48d0-83ee-da3aeaaf3a0d"> <start x="1240.0905" y="167.5"/> <end x="1357.5444" y="476.9804"/> </arc> <arc class="catalysis" id="modif_81581203-4ee8-4f2e-b209-e2bcf1e4057a" source="gf1_s5_gf1_sa134" target="pr_c96f806b-0b5a-48d0-83ee-da3aeaaf3a0d"> <start x="966.7556" y="167.5"/> <end x="1349.8868" y="483.41162"/> </arc> <arc class="catalysis" id="modif_342be852-a3be-4924-a54a-9ee6c5417612" source="gf1_s3_gf1_sa132" target="pr_c96f806b-0b5a-48d0-83ee-da3aeaaf3a0d"> <start x="1061.6791" y="167.5"/> <end x="1351.1132" y="469.32275"/> </arc> <arc class="catalysis" id="modif_f9f748dd-1b6a-48fc-8810-1142ccbd4cba" source="gf1_s1_gf1_sa130" target="pr_c96f806b-0b5a-48d0-83ee-da3aeaaf3a0d"> <start x="1155.5536" y="167.5"/> <end x="1357.5444" y="476.9804"/> </arc> <arc class="catalysis" id="modif_1dac787c-5f2d-436d-8241-ab1625c502ad" source="gf1_s6_gf1_sa135" target="pr_c96f806b-0b5a-48d0-83ee-da3aeaaf3a0d"> <start x="1418.0636" y="167.5"/> <end x="1351.1132" y="469.32275"/> </arc> <arc class="catalysis" id="modif_4116fc60-f36f-4b1d-95a4-dc1926be5865" source="gf1_s4_gf1_sa133" target="pr_c96f806b-0b5a-48d0-83ee-da3aeaaf3a0d"> <start x="1633.77" y="167.5"/> <end x="1351.1132" y="469.32275"/> </arc> <arc class="catalysis" id="modif_e1a92b59-6a50-444b-b08b-863c1065762a" source="gf1_s2_gf1_sa131" target="pr_c96f806b-0b5a-48d0-83ee-da3aeaaf3a0d"> <start x="1324.6272" y="167.5"/> <end x="1357.5444" y="476.9804"/> </arc> <arc class="consumption" id="cons_7acdf588-ba39-44f2-b8f8-880cb604e010" source="gf1_s4735_gf1_sa42" target="pr_aa12101a-91b1-4ab5-9b2a-2edcadbf88f6_p1"> <start x="748.4375" y="372.5"/> <end x="710.46875" y="425.0"/> </arc> <arc class="production" id="prod_ac974734-e88f-410b-b8fe-bca0a8d40a9f" source="pr_aa12101a-91b1-4ab5-9b2a-2edcadbf88f6_p2" target="gf1_s5200_gf1_csa22"> <start x="710.46875" y="455.0"/> <end x="672.5" y="507.5"/> </arc> <arc class="catalysis" id="modif_140ebd95-69fa-450d-9ef7-0f987460ea86" source="gf1_s5197_gf1_sa151" target="pr_aa12101a-91b1-4ab5-9b2a-2edcadbf88f6"> <start x="906.11884" y="547.5"/> <end x="706.1109" y="437.5487"/> </arc> <arc class="catalysis" id="modif_0528b6f5-6b85-4031-9d67-53b43f62b9cf" source="gf1_s5198_gf1_sa152" target="pr_aa12101a-91b1-4ab5-9b2a-2edcadbf88f6"> <start x="902.5" y="478.72528"/> <end x="717.27795" y="438.0934"/> </arc> <arc class="catalysis" id="modif_75a90233-7c6f-46a7-826a-95014c929234" source="gf1_s5199_gf1_sa153" target="pr_aa12101a-91b1-4ab5-9b2a-2edcadbf88f6"> <start x="907.5" y="411.34366"/> <end x="708.5622" y="433.19083"/> </arc> <arc class="consumption" id="addreact_424dfd00-20f7-4423-a942-a89d6e73254a" source="gf1_s4526_gf1_sa32" target="pr_aa12101a-91b1-4ab5-9b2a-2edcadbf88f6_p1"> <start x="657.1998" y="167.5"/> <end x="710.46875" y="425.0"/> </arc> <arc class="consumption" id="cons_3faf312c-0759-4378-acdb-e70b8ecc8294" source="gf1_s4468_gf1_sa66" target="pr_334da06b-e046-4bfb-a931-0c0f3b98182f_p1"> <start x="2502.5" y="147.5"/> <next x="2492.5" y="417.5"/> <end x="2497.7" y="454.5"/> </arc> <arc class="consumption" id="cons_b1105937-8221-498f-9ec3-64cc6f427e16" source="gf1_s4529_gf1_sa65" target="pr_334da06b-e046-4bfb-a931-0c0f3b98182f_p1"> <start x="2412.5" y="347.5"/> <next x="2492.5" y="417.5"/> <end x="2497.7" y="454.5"/> </arc> <arc class="production" id="prod_892c7d85-194e-4b74-88de-0ee1d851d378" source="pr_334da06b-e046-4bfb-a931-0c0f3b98182f_p2" target="gf1_s4530_gf1_csa15"> <start x="2497.7" y="484.5"/> <end x="2502.5" y="517.5"/> </arc> <arc class="consumption" id="cons_ed2e066b-fa99-4720-9dc3-930801f67b48" source="gf1_s4547_gf1_sa38" target="pr_cece030c-bb45-45eb-bd06-2736d974edb8_p1"> <start x="782.6818" y="707.5"/> <end x="783.0" y="727.5"/> </arc> <arc class="production" id="prod_17833a1f-1fea-40eb-a822-5a5828275c59" source="pr_cece030c-bb45-45eb-bd06-2736d974edb8_p2" target="gf1_s4554_gf1_sa37"> <start x="783.0" y="757.5"/> <end x="783.3182" y="777.5"/> </arc> <arc class="catalysis" id="modif_94129814-d644-4fa9-8882-a76a932cbe81" source="gf1_s5200_gf1_csa22" target="pr_cece030c-bb45-45eb-bd06-2736d974edb8"> <start x="672.5" y="627.5"/> <end x="787.95435" y="737.4548"/> </arc> <arc class="consumption" id="cons_76214d93-d57e-4785-ae55-eb95612b9912" source="gf1_s4563_gf1_sa56" target="pr_68519b01-8fa3-43a4-bac7-c65700e52336_p1"> <start x="1992.5" y="697.5"/> <end x="1992.5" y="712.5"/> </arc> <arc class="production" id="prod_da92e27e-9f57-4953-bc79-66468c15a80c" source="pr_68519b01-8fa3-43a4-bac7-c65700e52336_p2" target="gf1_s4564_gf1_sa55"> <start x="1992.5" y="742.5"/> <end x="1992.5" y="757.5"/> </arc> <arc class="catalysis" id="modif_f843f8e8-89ea-4f94-a2c1-68b67c809282" source="gf1_s4565_gf1_sa57" target="pr_68519b01-8fa3-43a4-bac7-c65700e52336"> <start x="1907.0834" y="572.5"/> <end x="1997.5" y="727.5"/> </arc> <arc class="consumption" id="cons_885449d4-bd1c-47dc-a470-086077c57de8" source="gf1_s4515_gf1_sa58" target="pr_41379f93-b45d-4554-8e52-7e8808f45813_p1"> <start x="1892.5" y="372.5"/> <end x="1892.5" y="432.5"/> </arc> <arc class="production" id="prod_2b02ac15-e4d5-4ff3-a4c4-a96c03461912" source="pr_41379f93-b45d-4554-8e52-7e8808f45813_p2" target="gf1_s4565_gf1_sa57"> <start x="1892.5" y="462.5"/> <end x="1892.5" y="522.5"/> </arc> <arc class="catalysis" id="modif_9c4b70af-0acc-468c-9791-4c45766e3357" source="gf1_s4508_gf1_sa53" target="pr_41379f93-b45d-4554-8e52-7e8808f45813"> <start x="1958.1666" y="167.5"/> <end x="1897.5" y="447.5"/> </arc> <arc class="catalysis" id="modif_379093dc-0b80-4d5b-94e0-c206ccf5c235" source="gf1_s4519_gf1_sa59" target="pr_41379f93-b45d-4554-8e52-7e8808f45813"> <start x="2098.4016" y="167.5"/> <end x="1897.5" y="452.5"/> </arc> <arc class="consumption" id="cons_b31b9f41-df1f-4897-a5eb-b4f5ebf4dd99" source="gf1_s4508_gf1_sa53" target="pr_be3fce50-7311-437e-9483-95299fbfeb49_p1"> <start x="1962.5" y="147.5"/> <next x="2122.5" y="447.5"/> <end x="2138.3572" y="469.5"/> </arc> <arc class="consumption" id="cons_1c2019d2-c31d-4ae6-a4e6-695ccb09cbbd" source="gf1_s4593_gf1_sa52" target="pr_be3fce50-7311-437e-9483-95299fbfeb49_p1"> <start x="2212.5" y="347.5"/> <next x="2122.5" y="447.5"/> <end x="2138.3572" y="469.5"/> </arc> <arc class="production" id="prod_a36c0f81-b452-481c-b3f4-e04dc53164d0" source="pr_be3fce50-7311-437e-9483-95299fbfeb49_p2" target="gf1_s4594_gf1_csa13"> <start x="2138.3572" y="499.5"/> <end x="2152.5" y="517.5"/> </arc> <arc class="consumption" id="cons_b962f6fc-58c2-4d49-a1d5-465b908a538a" source="gf1_s4594_gf1_csa13" target="pr_c0d7c666-ea67-4f8b-9423-8ecafc878428_p1"> <start x="2177.5" y="637.5"/> <end x="2197.5" y="653.9706"/> </arc> <arc class="production" id="prod_db90e86b-bf5b-4e41-8753-97ee06b57f7a" source="pr_c0d7c666-ea67-4f8b-9423-8ecafc878428_p2" target="gf1_s4597_gf1_sa63"> <start x="2227.5" y="653.9706"/> <end x="2247.5" y="670.44116"/> </arc> <arc class="consumption" id="cons_8c299f44-7a31-451d-be1e-eb2590552c5c" source="gf1_s3866_gf1_sa137" target="pr_b1955777-59f9-4e0a-897e-ea41d90511af_p1"> <start x="3292.5" y="347.5"/> <next x="3352.5" y="407.5"/> <end x="3349.147" y="449.5"/> </arc> <arc class="consumption" id="cons_66415498-5983-4a07-a910-a8e5349eabee" source="gf1_s5191_gf1_sa136" target="pr_b1955777-59f9-4e0a-897e-ea41d90511af_p1"> <start x="3302.5" y="147.5"/> <next x="3352.5" y="407.5"/> <end x="3349.147" y="449.5"/> </arc> <arc class="production" id="prod_8da9758b-ef8f-4f9c-a44c-b0ca6b0d1329" source="pr_b1955777-59f9-4e0a-897e-ea41d90511af_p2" target="gf1_s5209_gf1_csa20"> <start x="3349.147" y="479.5"/> <end x="3346.0293" y="517.5"/> </arc> <arc class="consumption" id="cons_17b936d5-ed82-41a5-9a6e-41aaa8060587" source="gf1_s5191_gf1_sa136" target="pr_6560ab4c-f401-4a34-96cb-0edcbcf4cb72_p1"> <start x="3302.5" y="147.5"/> <next x="3512.5" y="327.5"/> <end x="3542.74" y="407.0"/> </arc> <arc class="consumption" id="cons_fd77fab5-6b4c-4188-9b04-3dd6707ff3b3" source="gf1_s3913_gf1_sa138" target="pr_6560ab4c-f401-4a34-96cb-0edcbcf4cb72_p1"> <start x="3642.5" y="347.5"/> <next x="3512.5" y="327.5"/> <end x="3542.74" y="407.0"/> </arc> <arc class="production" id="prod_9c50bd09-1e29-41ec-a7de-ef70012e6627" source="pr_6560ab4c-f401-4a34-96cb-0edcbcf4cb72_p2" target="gf1_s5210_gf1_csa21"> <start x="3542.74" y="437.0"/> <end x="3571.7" y="512.5"/> </arc> <arc class="consumption" id="cons_70426575-fa60-4db2-950e-977b6fa5e22e" source="gf1_s417_gf1_csa8" target="pr_6df32f2b-0b17-45bd-b8bb-61efe590fae4_p1"> <start x="212.5" y="622.5"/> <end x="532.5" y="884.375"/> </arc> <arc class="production" id="prod_cd1c2017-9ba4-48fc-9ead-a6e3007aefe3" source="pr_6df32f2b-0b17-45bd-b8bb-61efe590fae4_p2" target="gf1_s5196_gf1_sa150"> <start x="562.5" y="884.375"/> <end x="882.5" y="1146.25"/> </arc> <arc class="consumption" id="cons_da6e040a-fc64-4772-85ef-f3f311a6be75" source="gf1_s417_gf1_csa8" target="pr_347f49c5-b5db-425d-9b3f-5fab35c7c184_p1"> <start x="312.5" y="622.5"/> <end x="750.625" y="838.125"/> </arc> <arc class="production" id="prod_2f639710-5930-49ca-ba7a-18aaf244cd7d" source="pr_347f49c5-b5db-425d-9b3f-5fab35c7c184_p2" target="gf1_s5193_gf1_sa147"> <start x="780.625" y="838.125"/> <end x="1218.75" y="1053.75"/> </arc> <arc class="consumption" id="cons_323f12af-3df1-4cc3-b4ff-cda6466c5b4b" source="gf1_s417_gf1_csa8" target="pr_492f258e-7a2a-4be9-a510-e950a396170a_p1"> <start x="312.5" y="622.5"/> <end x="1048.75" y="895.0"/> </arc> <arc class="production" id="prod_c00cfd63-d8d8-4753-8d79-617ace80ddad" source="pr_492f258e-7a2a-4be9-a510-e950a396170a_p2" target="gf1_s5194_gf1_sa148"> <start x="1078.75" y="895.0"/> <end x="1815.0" y="1167.5"/> </arc> <arc class="consumption" id="cons_ebe3f884-b697-41ba-bb61-16b87743f00e" source="gf1_s417_gf1_csa8" target="pr_4ee3945b-69b0-4f83-a76c-14c81ba9ede9_p1"> <start x="312.5" y="622.5"/> <end x="1394.375" y="865.0"/> </arc> <arc class="production" id="prod_9a7e921d-6db8-49d5-ac48-0a0422e74476" source="pr_4ee3945b-69b0-4f83-a76c-14c81ba9ede9_p2" target="gf1_s5192_gf1_sa146"> <start x="1424.375" y="865.0"/> <end x="2506.25" y="1107.5"/> </arc> <arc class="consumption" id="cons_c011d573-f67e-446b-8a62-f81c976ecc16" source="gf1_s5200_gf1_csa22" target="pr_4dca2d5b-0f94-460e-be11-c524da7202e7_p1"> <start x="622.5" y="627.5"/> <end x="954.0625" y="840.625"/> </arc> <arc class="production" id="prod_b83e8ffe-f71a-4eee-885b-0bea5d96548b" source="pr_4dca2d5b-0f94-460e-be11-c524da7202e7_p2" target="gf1_s5193_gf1_sa147"> <start x="984.0625" y="840.625"/> <end x="1315.625" y="1053.75"/> </arc> <arc class="consumption" id="cons_887b58eb-345f-4919-874e-235ae99e4412" source="gf1_s4554_gf1_sa37" target="pr_d8dca37c-7dd2-4444-926f-7a0fefad9556_p1"> <start x="823.5" y="811.29395"/> <end x="1309.5625" y="984.0845"/> </arc> <arc class="production" id="prod_e01adb68-7dc7-4cc0-9ea0-9aab675c4289" source="pr_d8dca37c-7dd2-4444-926f-7a0fefad9556_p2" target="gf1_s5194_gf1_sa148"> <start x="1339.5625" y="984.0845"/> <end x="1825.625" y="1156.875"/> </arc> <arc class="consumption" id="cons_f98d6b37-15cb-4290-af2f-af48cfee8c23" source="gf1_s4554_gf1_sa37" target="pr_2f43b005-35a7-4929-9030-451716d6a09e_p1"> <start x="823.5" y="804.6978"/> <end x="1649.875" y="956.0989"/> </arc> <arc class="production" id="prod_c0010143-2f3a-43a5-997f-a7c83eb23f56" source="pr_2f43b005-35a7-4929-9030-451716d6a09e_p2" target="gf1_s5192_gf1_sa146"> <start x="1679.875" y="956.0989"/> <end x="2506.25" y="1107.5"/> </arc> <arc class="consumption" id="cons_aceacf9f-71e8-4e9a-acc8-d83b99a1a03c" source="gf1_s5200_gf1_csa22" target="pr_82fc905a-73f4-48c4-b6cd-08768493e51b_p1"> <start x="622.5" y="627.5"/> <end x="752.5" y="871.875"/> </arc> <arc class="production" id="prod_57674411-28f9-4ce2-bc2d-ef7130bf6123" source="pr_82fc905a-73f4-48c4-b6cd-08768493e51b_p2" target="gf1_s5196_gf1_sa150"> <start x="752.5" y="901.875"/> <end x="882.5" y="1146.25"/> </arc> <arc class="consumption" id="cons_a895e047-e11d-4345-8bc1-b38e5e3aa509" source="gf1_s419_gf1_csa10" target="pr_d253e464-76dd-43ba-a860-761585bac1cf_p1"> <start x="1222.5" y="648.75"/> <end x="1860.3125" y="867.1875"/> </arc> <arc class="production" id="prod_846d02cc-091d-491c-9107-c33a01f359e4" source="pr_d253e464-76dd-43ba-a860-761585bac1cf_p2" target="gf1_s5192_gf1_sa146"> <start x="1890.3125" y="867.1875"/> <end x="2528.125" y="1085.625"/> </arc> <arc class="consumption" id="cons_b3873c18-6ee2-4e35-9a50-a4717ddd22a2" source="gf1_s419_gf1_csa10" target="pr_02ed535d-c65e-4982-bf70-4ee7783aca41_p1"> <start x="1172.5" y="648.75"/> <end x="1489.375" y="897.5"/> </arc> <arc class="production" id="prod_783be785-3027-4897-b04f-cc8bd1e03c63" source="pr_02ed535d-c65e-4982-bf70-4ee7783aca41_p2" target="gf1_s5194_gf1_sa148"> <start x="1519.375" y="897.5"/> <end x="1836.25" y="1146.25"/> </arc> <arc class="consumption" id="cons_35de45b7-102b-4894-ab3a-c91f78406108" source="gf1_s419_gf1_csa10" target="pr_81d1aff0-08b8-4115-8ecb-351cbbb78ce2_p1"> <start x="1222.5" y="648.75"/> <end x="1414.375" y="836.25"/> </arc> <arc class="production" id="prod_121ebe6a-7a03-421d-9325-792a0c92bdd1" source="pr_81d1aff0-08b8-4115-8ecb-351cbbb78ce2_p2" target="gf1_s5193_gf1_sa147"> <start x="1414.375" y="866.25"/> <end x="1606.25" y="1053.75"/> </arc> <arc class="consumption" id="cons_a704d459-0d8e-429b-b45b-dc14b54cefb7" source="gf1_s419_gf1_csa10" target="pr_2b232a6d-aa7a-4932-ba33-54b66b6beeb5_p1"> <start x="1172.5" y="648.75"/> <end x="1103.125" y="882.5"/> </arc> <arc class="production" id="prod_d2d55e57-52dd-4c4d-9d84-f8ab16dd79f7" source="pr_2b232a6d-aa7a-4932-ba33-54b66b6beeb5_p2" target="gf1_s5196_gf1_sa150"> <start x="1103.125" y="912.5"/> <end x="1033.75" y="1146.25"/> </arc> <arc class="consumption" id="cons_76d07993-fb0c-4346-8587-169bd9817b48" source="gf1_s4564_gf1_sa55" target="pr_528791d5-dc5e-4de6-8dd4-ca93f614a857_p1"> <start x="1952.5" y="797.5"/> <end x="1894.375" y="956.875"/> </arc> <arc class="production" id="prod_fc47edd6-5a34-429a-a66b-1a83c7bc4ed5" source="pr_528791d5-dc5e-4de6-8dd4-ca93f614a857_p2" target="gf1_s5194_gf1_sa148"> <start x="1894.375" y="986.875"/> <end x="1836.25" y="1146.25"/> </arc> <arc class="consumption" id="cons_8e999a02-b097-4f8e-80f8-a36aaa5427f1" source="gf1_s4565_gf1_sa57" target="pr_68f57928-fcfb-49d6-9171-6c3a8ea60f72_p1"> <start x="1926.5447" y="572.5"/> <end x="2260.9287" y="829.0625"/> </arc> <arc class="production" id="prod_0e769bdf-d322-4bb4-b719-ce19e65e592a" source="pr_68f57928-fcfb-49d6-9171-6c3a8ea60f72_p2" target="gf1_s5192_gf1_sa146"> <start x="2290.9287" y="829.0625"/> <end x="2625.3125" y="1085.625"/> </arc> <arc class="consumption" id="cons_7e12caa4-2b97-436e-8c38-14d24c1295a0" source="gf1_s8_gf1_sa144" target="pr_6ceccc9d-dbec-40d3-9a21-6749fca77dab_p1"> <start x="2712.5" y="147.5"/> <next x="2712.5" y="397.5"/> <end x="2712.5" y="444.5"/> </arc> <arc class="consumption" id="cons_a296726c-a4b9-4703-88a8-ca033716788f" source="gf1_s9_gf1_sa145" target="pr_6ceccc9d-dbec-40d3-9a21-6749fca77dab_p1"> <start x="2842.5" y="347.5"/> <next x="2712.5" y="397.5"/> <end x="2712.5" y="444.5"/> </arc> <arc class="production" id="prod_83bddf88-06a7-40b3-a3c6-7f3f4477b73d" source="pr_6ceccc9d-dbec-40d3-9a21-6749fca77dab_p2" target="gf1_s5203_gf1_csa23"> <start x="2712.5" y="474.5"/> <end x="2712.5" y="517.5"/> </arc> <arc class="consumption" id="cons_1b804b9b-8aee-4802-a2f8-8c8f990fdf09" source="gf1_s5203_gf1_csa23" target="pr_24aeb168-eaff-4e39-8950-a59e997c04ff_p1"> <start x="2662.5" y="637.5"/> <end x="2435.625" y="876.875"/> </arc> <arc class="production" id="prod_39111953-ab9f-4081-9c64-8b6295481234" source="pr_24aeb168-eaff-4e39-8950-a59e997c04ff_p2" target="gf1_s5194_gf1_sa148"> <start x="2435.625" y="906.875"/> <end x="2208.75" y="1146.25"/> </arc> <arc class="consumption" id="cons_188b8acc-15ea-4cba-9ae8-91e73cc27fa5" source="gf1_s5203_gf1_csa23" target="pr_1671a113-be10-4e99-bc29-8196bb96e826_p1"> <start x="2687.5" y="637.5"/> <end x="2656.4062" y="846.5625"/> </arc> <arc class="production" id="prod_ee45955e-bebc-4c29-bc1b-9b8039b18522" source="pr_1671a113-be10-4e99-bc29-8196bb96e826_p2" target="gf1_s5192_gf1_sa146"> <start x="2656.4062" y="876.5625"/> <end x="2625.3125" y="1085.625"/> </arc> <arc class="consumption" id="cons_e80f6179-74f6-4ca3-84ff-99876cb80296" source="gf1_s4530_gf1_csa15" target="pr_3912d9bf-8c85-4c0b-9b12-5336ed9c962d_p1"> <start x="2452.5" y="637.5"/> <end x="2050.3125" y="851.5625"/> </arc> <arc class="production" id="prod_959da660-0e84-4b4f-b660-4b10595b5287" source="pr_3912d9bf-8c85-4c0b-9b12-5336ed9c962d_p2" target="gf1_s5193_gf1_sa147"> <start x="2020.3125" y="851.5625"/> <end x="1618.125" y="1065.625"/> </arc> <arc class="consumption" id="cons_cd01a212-0649-46ac-869a-49d51542c190" source="gf1_s4530_gf1_csa15" target="pr_dab8448d-0065-425f-99a0-d8963bf75ae7_p1"> <start x="2452.5" y="637.5"/> <end x="2205.9375" y="891.875"/> </arc> <arc class="production" id="prod_46991b26-741b-47e9-a12d-3f54dd339cae" source="pr_dab8448d-0065-425f-99a0-d8963bf75ae7_p2" target="gf1_s5194_gf1_sa148"> <start x="2175.9375" y="891.875"/> <end x="1929.375" y="1146.25"/> </arc> <arc class="consumption" id="cons_f2a2e32c-f817-4cf2-9216-ac816786055b" source="gf1_s4530_gf1_csa15" target="pr_29983cdf-c514-4b8c-8020-e87e0fd2e97b_p1"> <start x="2452.5" y="637.5"/> <end x="1758.125" y="891.875"/> </arc> <arc class="production" id="prod_86bd5381-e339-461e-bb85-bd3fa49746e3" source="pr_29983cdf-c514-4b8c-8020-e87e0fd2e97b_p2" target="gf1_s5196_gf1_sa150"> <start x="1728.125" y="891.875"/> <end x="1033.75" y="1146.25"/> </arc> <arc class="consumption" id="cons_d4edaeca-238d-43aa-a5d7-c482eb959675" source="gf1_s4530_gf1_csa15" target="pr_873036bc-b838-4dbe-a89d-09dd96abc8ad_p1"> <start x="2452.5" y="637.5"/> <end x="2538.9062" y="846.5625"/> </arc> <arc class="production" id="prod_91e0028d-1af2-4b40-98a5-874669eeeb19" source="pr_873036bc-b838-4dbe-a89d-09dd96abc8ad_p2" target="gf1_s5192_gf1_sa146"> <start x="2538.9062" y="876.5625"/> <end x="2625.3125" y="1085.625"/> </arc> <arc class="consumption" id="cons_a0a62a93-ad58-4160-af86-9233a28c8cc6" source="gf1_s5191_gf1_sa136" target="pr_ba11f720-ce63-4120-b662-be3526070477_p1"> <start x="3302.5" y="147.5"/> <next x="3112.5" y="417.5"/> <end x="3096.9" y="454.5"/> </arc> <arc class="consumption" id="cons_c416e846-b691-4d8c-9b36-5da8c55cef3e" source="gf1_s7_gf1_sa143" target="pr_ba11f720-ce63-4120-b662-be3526070477_p1"> <start x="3022.5" y="347.5"/> <next x="3112.5" y="417.5"/> <end x="3096.9" y="454.5"/> </arc> <arc class="production" id="prod_2a3d9100-7f28-4f83-8e0a-b8f969b2c713" source="pr_ba11f720-ce63-4120-b662-be3526070477_p2" target="gf1_s5206_gf1_csa24"> <start x="3096.9" y="484.5"/> <end x="3082.5" y="517.5"/> </arc> <arc class="consumption" id="cons_fb6ea4d0-1664-4603-830f-0375120fb86d" source="gf1_s5206_gf1_csa24" target="pr_ab72fbee-303d-4bb9-aa50-e206e322c00f_p1"> <start x="3057.5" y="637.5"/> <end x="2648.125" y="891.875"/> </arc> <arc class="production" id="prod_1f665b09-6b1c-46a1-9588-e4da2256f05f" source="pr_ab72fbee-303d-4bb9-aa50-e206e322c00f_p2" target="gf1_s5194_gf1_sa148"> <start x="2618.125" y="891.875"/> <end x="2208.75" y="1146.25"/> </arc> <arc class="consumption" id="cons_6018566b-b3d6-4a76-b7fd-1357055318ba" source="gf1_s5210_gf1_csa21" target="pr_4415261d-c985-4559-b463-bbdc2ebee03c_p1"> <start x="3542.5" y="642.5"/> <end x="2601.25" y="860.0"/> </arc> <arc class="production" id="prod_2e599fb8-a2b1-4a9d-bd37-4cb54c8a8ed6" source="pr_4415261d-c985-4559-b463-bbdc2ebee03c_p2" target="gf1_s5193_gf1_sa147"> <start x="2571.25" y="860.0"/> <end x="1630.0" y="1077.5"/> </arc> <arc class="consumption" id="cons_8e17ba4a-ff09-4f44-b0c2-4197cefa2e8c" source="gf1_s5210_gf1_csa21" target="pr_79e0b68d-fee6-4901-b6fa-de865faaaa09_p1"> <start x="3567.5" y="642.5"/> <end x="2903.125" y="894.375"/> </arc> <arc class="production" id="prod_e32dbdd7-8e33-43b5-824c-04955d5fb6fc" source="pr_79e0b68d-fee6-4901-b6fa-de865faaaa09_p2" target="gf1_s5194_gf1_sa148"> <start x="2873.125" y="894.375"/> <end x="2208.75" y="1146.25"/> </arc> <arc class="consumption" id="cons_72a5ba80-78b9-4293-bd41-0838833449a3" source="gf1_s5209_gf1_csa20" target="pr_fa249708-c916-42d3-8636-61f64a8fb9d1_p1"> <start x="3292.5" y="637.5"/> <end x="2765.625" y="891.875"/> </arc> <arc class="production" id="prod_fecb4af6-5c2c-465d-93c7-02ea61ccd169" source="pr_fa249708-c916-42d3-8636-61f64a8fb9d1_p2" target="gf1_s5194_gf1_sa148"> <start x="2735.625" y="891.875"/> <end x="2208.75" y="1146.25"/> </arc> <arc class="consumption" id="cons_e102c51b-8759-4629-9422-efb57c2ca651" source="gf1_s5209_gf1_csa20" target="pr_78d1e500-892f-4aa7-8267-dc83372c2fed_p1"> <start x="3292.5" y="637.5"/> <end x="2476.25" y="857.5"/> </arc> <arc class="production" id="prod_704ef155-7806-44ab-9b70-e36a2ac22c88" source="pr_78d1e500-892f-4aa7-8267-dc83372c2fed_p2" target="gf1_s5193_gf1_sa147"> <start x="2446.25" y="857.5"/> <end x="1630.0" y="1077.5"/> </arc> <arc class="consumption" id="cons_ca9bd2fb-7b6c-4af7-9fa3-146029f4cc4c" source="mpk1_mpk1_s25_mpk1_mpk1_sa28" target="pr_bdcb1a48-bc9b-417f-adf9-2d5784874270_p1"> <start x="762.5" y="1734.0"/> <next x="912.0" y="1596.6875"/> <end x="930.92725" y="1613.8438"/> </arc> <arc class="consumption" id="cons_6a83a2be-b756-4594-bf43-54724fcae542" source="mpk1_mpk1_s989_mpk1_mpk1_csa6" target="pr_bdcb1a48-bc9b-417f-adf9-2d5784874270_p1"> <start x="872.75" y="1491.0"/> <next x="912.0" y="1596.6875"/> <end x="930.92725" y="1613.8438"/> </arc> <arc class="production" id="prod_1bc1c1e0-b9e1-4644-9a68-b5909ef4c35e" source="pr_bdcb1a48-bc9b-417f-adf9-2d5784874270_p2" target="mpk1_mpk1_s991_mpk1_mpk1_csa3"> <start x="930.92725" y="1643.8438"/> <end x="947.5" y="1657.0"/> </arc> <arc class="catalysis" id="modif_b97d6144-49c6-478b-b4a6-e783ee2eb4f1" source="mpk1_mpk1_s963_mpk1_mpk1_sa711" target="pr_bdcb1a48-bc9b-417f-adf9-2d5784874270"> <start x="2637.5" y="2657.5"/> <next x="2631.79" y="2270.3997"/> <next x="2010.4266" y="2270.7456"/> <next x="2010.1484" y="1771.2574"/> <next x="1061.1207" y="1771.7859"/> <next x="1061.0374" y="1621.9395"/> <end x="935.2362" y="1626.3075"/> </arc> <arc class="catalysis" id="modif_25c948dc-006a-4016-a051-af8daa96caf0" source="mpk1_mpk1_s977_mpk1_mpk1_sa720" target="pr_bdcb1a48-bc9b-417f-adf9-2d5784874270"> <start x="2545.0" y="2655.0"/> <next x="2544.9058" y="2273.5928"/> <next x="2009.8735" y="2270.4136"/> <next x="2012.805" y="1772.4037"/> <next x="1062.9438" y="1771.5892"/> <next x="1062.6312" y="1623.9967"/> <end x="937.7725" y="1630.6165"/> </arc> <arc class="consumption" id="cons_c698550f-9af2-4741-ae8a-0c9e52f42264" source="mpk1_mpk1_s991_mpk1_mpk1_csa3" target="pr_b6807c24-861f-468b-9c0c-d9cfac0f7bee_p1"> <start x="1019.0" y="1708.5"/> <next x="1186.75" y="1617.5"/> <next x="1345.5" y="1617.5"/> <end x="1345.5" y="1566.0"/> </arc> <arc class="consumption" id="cons_e6799f29-3813-4bb1-bf61-e4f940e0d12c" source="mpk1_mpk1_s142_mpk1_mpk1_sa48" target="pr_b6807c24-861f-468b-9c0c-d9cfac0f7bee_p1"> <start x="1345.5" y="1809.5"/> <next x="1345.5" y="1781.0"/> <next x="1345.5" y="1781.0"/> <next x="1345.5" y="1617.5"/> <end x="1345.5" y="1566.0"/> </arc> <arc class="production" id="prod_d85160e4-3374-4157-90af-c700868e6a48" source="pr_b6807c24-861f-468b-9c0c-d9cfac0f7bee_p2" target="mpk1_mpk1_s993_mpk1_mpk1_csa4"> <start x="1345.5" y="1536.0"/> <next x="1345.5" y="1488.5"/> <end x="1430.0" y="1488.5"/> </arc> <arc class="catalysis" id="modif_84b332de-12b3-4d85-a305-f120d47398eb" source="mpk1_mpk1_s230_mpk1_mpk1_sa144" target="pr_b6807c24-861f-468b-9c0c-d9cfac0f7bee"> <start x="1690.0" y="2212.25"/> <next x="1608.9626" y="2204.7954"/> <next x="1599.5083" y="2011.9382"/> <next x="1525.6628" y="2011.8456"/> <next x="1520.786" y="1872.0729"/> <next x="1393.2819" y="1873.5017"/> <next x="1378.7491" y="1550.8982"/> <end x="1350.5" y="1551.0"/> </arc> <arc class="consumption" id="cons_a7094aa7-6f84-4dfb-ab7e-c2ca7272e34d" source="mpk1_mpk1_s993_mpk1_mpk1_csa4" target="pr_4ac6d449-7ee7-4e41-80e8-2e854cfbaf5f_p1"> <start x="1619.0" y="1488.5"/> <next x="1729.5" y="1488.5"/> <end x="1755.0" y="1489.026"/> </arc> <arc class="consumption" id="cons_1c594e62-fa71-4830-a7bf-004972d025c3" source="mpk1_mpk1_s1030_mpk1_mpk1_csa27" target="pr_4ac6d449-7ee7-4e41-80e8-2e854cfbaf5f_p1"> <start x="1743.0" y="1838.0"/> <next x="1729.5" y="1488.5"/> <end x="1755.0" y="1489.026"/> </arc> <arc class="production" id="prod_adc8e7fb-110c-4687-bdeb-5d164da71f6d" source="pr_4ac6d449-7ee7-4e41-80e8-2e854cfbaf5f_p2" target="mpk1_mpk1_s995_mpk1_mpk1_csa11"> <start x="1785.0" y="1489.026"/> <end x="1806.5" y="1489.5"/> </arc> <arc class="consumption" id="cons_ba9e0589-f827-4007-846e-9412f0779d44" source="mpk1_mpk1_s995_mpk1_mpk1_csa11" target="pr_ac505458-d7a8-4426-b175-dbd0bee9c4e0_p1"> <start x="1806.5" y="1573.5"/> <next x="1809.0" y="1641.0"/> <end x="1756.25" y="1641.1288"/> </arc> <arc class="consumption" id="cons_fa532eed-ff8f-4795-98ef-62ffc5c876df" source="mpk1_mpk1_s174_mpk1_mpk1_sa64" target="pr_ac505458-d7a8-4426-b175-dbd0bee9c4e0_p1"> <start x="2115.0" y="2604.5"/> <next x="1818.5017" y="2607.182"/> <next x="1809.0" y="1641.0"/> <end x="1756.25" y="1641.1288"/> </arc> <arc class="production" id="prod_bbb52ab6-9646-4052-82fd-43a1d5d26821" source="pr_ac505458-d7a8-4426-b175-dbd0bee9c4e0_p2" target="mpk1_mpk1_s994_mpk1_mpk1_csa12"> <start x="1726.25" y="1641.1288"/> <end x="1677.5" y="1641.25"/> </arc> <arc class="consumption" id="cons_f6aa89f7-1533-40be-9d02-9ebcc02a1e08" source="mpk1_mpk1_s114_mpk1_mpk1_sa76" target="pr_fa588ae4-b141-43bd-83d5-af97ce8c7036_p1"> <start x="1394.5" y="2230.625"/> <next x="1344.0" y="2227.0"/> <end x="1322.0387" y="2226.0166"/> </arc> <arc class="consumption" id="cons_4dfae759-1ed6-4752-9df2-20f1bf9a94a9" source="mpk1_mpk1_s113_mpk1_mpk1_sa75" target="pr_fa588ae4-b141-43bd-83d5-af97ce8c7036_p1"> <start x="1562.5" y="2091.0"/> <next x="1344.0366" y="2204.1733"/> <next x="1344.0" y="2227.0"/> <end x="1322.0387" y="2226.0166"/> </arc> <arc class="production" id="prod_10e33516-5524-4975-8c2c-f668a7c9ab87" source="pr_fa588ae4-b141-43bd-83d5-af97ce8c7036_p2" target="mpk1_mpk1_s1011_mpk1_mpk1_csa14"> <start x="1292.0387" y="2226.0166"/> <next x="1274.0774" y="2225.1396"/> <end x="1282.5" y="2254.0"/> </arc> <arc class="consumption" id="cons_18d8020b-9768-4fd7-afdc-a948da13943c" source="mpk1_mpk1_s327_mpk1_mpk1_sa264" target="pr_7c3ef998-77b6-4479-93c1-d204ceb7458c_p1"> <start x="1985.0" y="2530.0"/> <next x="1653.7991" y="2530.326"/> <next x="1649.9498" y="2299.0388"/> <next x="1517.0001" y="2298.0"/> <next x="1518.6893" y="2417.1877"/> <end x="1456.8447" y="2418.8438"/> </arc> <arc class="consumption" id="cons_51af2fca-a2ad-4ec3-baef-3f49004c3869" source="mpk1_mpk1_s1011_mpk1_mpk1_csa14" target="pr_7c3ef998-77b6-4479-93c1-d204ceb7458c_p1"> <start x="1342.0" y="2303.0"/> <next x="1517.0001" y="2298.0"/> <next x="1518.6893" y="2417.1877"/> <end x="1456.8447" y="2418.8438"/> </arc> <arc class="production" id="prod_be8e9c05-1399-479c-9a7b-6ff45d066aef" source="pr_7c3ef998-77b6-4479-93c1-d204ceb7458c_p2" target="mpk1_mpk1_s1012_mpk1_mpk1_csa15"> <start x="1426.8447" y="2418.8438"/> <end x="1365.0" y="2420.5"/> </arc> <arc class="consumption" id="cons_418eab44-2168-480d-b76e-6778d3bf6d43" source="mpk1_mpk1_s991_mpk1_mpk1_csa3" target="pr_8a6dd9ae-e5f9-4f7a-b0ba-d324ac90879e_p1"> <start x="876.0" y="1708.5"/> <next x="810.0" y="1820.0"/> <next x="820.0" y="2160.0"/> <next x="1182.5" y="2164.6562"/> <end x="1146.0823" y="2193.3281"/> </arc> <arc class="consumption" id="cons_0d0c96ae-dd1d-4702-9dfd-7d221567b120" source="mpk1_mpk1_s1012_mpk1_mpk1_csa15" target="pr_8a6dd9ae-e5f9-4f7a-b0ba-d324ac90879e_p1"> <start x="1207.0" y="2420.5"/> <next x="1188.7948" y="2417.0745"/> <next x="1182.5" y="2164.6562"/> <end x="1146.0823" y="2193.3281"/> </arc> <arc class="production" id="prod_5cc1843b-e676-4f97-9f70-636a7d6ce81f" source="pr_8a6dd9ae-e5f9-4f7a-b0ba-d324ac90879e_p2" target="mpk1_mpk1_s1013_mpk1_mpk1_csa16"> <start x="1146.0823" y="2223.3281"/> <end x="1113.0" y="2248.0"/> </arc> <arc class="consumption" id="cons_0465afa6-1f31-4911-94b5-580759aab34e" source="mpk1_mpk1_s358_mpk1_mpk1_sa240" target="pr_9b587785-9ed7-493f-a9b7-ecb740f8ceb6_p1"> <start x="826.5" y="2215.0"/> <next x="832.0" y="2324.5"/> <next x="917.0149" y="2407.343"/> <end x="973.75745" y="2472.4214"/> </arc> <arc class="consumption" id="cons_c7fb0d30-0ca6-44db-ab82-2a8689da2a35" source="mpk1_mpk1_s1013_mpk1_mpk1_csa16" target="pr_9b587785-9ed7-493f-a9b7-ecb740f8ceb6_p1"> <start x="906.0" y="2324.0"/> <next x="832.0" y="2324.5"/> <next x="917.0149" y="2407.343"/> <end x="973.75745" y="2472.4214"/> </arc> <arc class="production" id="prod_cfd6cd13-ccab-4a22-a411-fe3edb6f0f5a" source="pr_9b587785-9ed7-493f-a9b7-ecb740f8ceb6_p2" target="mpk1_mpk1_s1014_mpk1_mpk1_csa18"> <start x="1003.75745" y="2472.4214"/> <end x="1060.5" y="2537.5"/> </arc> <arc class="catalysis" id="modif_80c14640-790b-4e7d-b14d-1f7f551bbb5a" source="mpk1_mpk1_s230_mpk1_mpk1_sa144" target="pr_9b587785-9ed7-493f-a9b7-ecb740f8ceb6"> <start x="1690.0" y="2224.75"/> <next x="904.20905" y="2205.4854"/> <next x="950.60236" y="2424.1907"/> <end x="988.41345" y="2465.3586"/> </arc> <arc class="consumption" id="cons_7495025a-18c6-4eff-a43b-3a5ed8f41c49" source="mpk1_mpk1_s174_mpk1_mpk1_sa64" target="pr_8b98083f-4ef3-4059-bd53-a6671244da68_p1"> <start x="2152.5" y="2617.0"/> <next x="2155.7122" y="2742.2488"/> <next x="1389.5078" y="2743.5"/> <end x="1396.5854" y="2727.5"/> </arc> <arc class="consumption" id="cons_eb0b9c8c-a680-4354-8914-07c8d416f2e2" source="mpk1_mpk1_s1014_mpk1_mpk1_csa18" target="pr_8b98083f-4ef3-4059-bd53-a6671244da68_p1"> <start x="1138.5" y="2683.5"/> <next x="1113.6093" y="2739.5503"/> <next x="1389.5078" y="2743.5"/> <end x="1396.5854" y="2727.5"/> </arc> <arc class="production" id="prod_ba179bc4-05fc-4806-8b71-da13e70aee21" source="pr_8b98083f-4ef3-4059-bd53-a6671244da68_p2" target="mpk1_mpk1_s1015_mpk1_mpk1_csa19"> <start x="1396.5854" y="2697.5"/> <end x="1402.75" y="2685.5"/> </arc> <arc class="consumption" id="cons_5fd013be-0ab5-4244-98dd-1aaef1debd1b" source="mpk1_mpk1_s1009_mpk1_mpk1_csa21" target="pr_1067b7c3-4b1b-421c-98af-3ba4cfdce0d9_p1"> <start x="695.5" y="1842.0"/> <next x="694.0" y="1691.5"/> <end x="743.2683" y="1578.25"/> </arc> <arc class="consumption" id="cons_83c0f9c0-c5c0-4953-847b-f06d5cce124a" source="mpk1_mpk1_s384_mpk1_mpk1_sa22" target="pr_1067b7c3-4b1b-421c-98af-3ba4cfdce0d9_p1"> <start x="690.0" y="1342.5"/> <next x="694.0" y="1691.5"/> <end x="743.2683" y="1578.25"/> </arc> <arc class="production" id="prod_1e55ad17-8d5d-4652-b668-0048e7d617e6" source="pr_1067b7c3-4b1b-421c-98af-3ba4cfdce0d9_p2" target="mpk1_mpk1_s989_mpk1_mpk1_csa6"> <start x="743.2683" y="1548.25"/> <end x="791.0" y="1439.0"/> </arc> <arc class="inhibition" id="modif_7c6e61d1-1494-46b8-a9e6-cff8fb332eb6" source="mpk1_mpk1_s983_mpk1_mpk1_csa110" target="pr_1067b7c3-4b1b-421c-98af-3ba4cfdce0d9"> <start x="677.0" y="1430.5"/> <next x="737.2025" y="1429.8602"/> <end x="738.6009" y="1561.4569"/> </arc> <arc class="catalysis" id="modif_46096b9b-9533-4c10-9df3-1c07a8704577" source="mpk1_mpk1_s961_mpk1_mpk1_sa709" target="pr_1067b7c3-4b1b-421c-98af-3ba4cfdce0d9"> <start x="960.0" y="1532.5"/> <next x="959.84937" y="1549.9131"/> <next x="770.7924" y="1548.2776"/> <end x="747.9357" y="1565.0431"/> </arc> <arc class="consumption" id="cons_23a581aa-73f5-4f15-9b48-df63449fb244" source="mpk1_mpk1_s994_mpk1_mpk1_csa12" target="pr_63012166-6a56-4e61-8b41-a0aa5fb29fb0_p1"> <start x="1677.5" y="1722.75"/> <end x="1697.75" y="1723.1049"/> </arc> <arc class="production" id="prod_175fa07b-7755-491f-8c68-8bf7403a9641" source="pr_63012166-6a56-4e61-8b41-a0aa5fb29fb0_p2" target="mpk1_mpk1_s1030_mpk1_mpk1_csa27"> <start x="1727.75" y="1723.1049"/> <next x="1748.0" y="1723.4597"/> <end x="1771.0" y="1838.0"/> </arc> <arc class="production" id="prod_f441c557-eac1-42aa-bb8f-fbb284c813d3" source="pr_63012166-6a56-4e61-8b41-a0aa5fb29fb0_p2" target="mpk1_mpk1_s993_mpk1_mpk1_csa4"> <start x="1727.75" y="1723.1049"/> <next x="1748.0" y="1723.4597"/> <next x="1749.5718" y="1515.001"/> <end x="1619.0" y="1514.25"/> </arc> <arc class="production" id="addprod_1005772f-5807-475a-8006-c1149c0ed2e9" source="pr_63012166-6a56-4e61-8b41-a0aa5fb29fb0_p2" target="mpk1_mpk1_s603_mpk1_mpk1_sa259"> <start x="1727.75" y="1723.1049"/> <end x="2332.1667" y="2592.8335"/> </arc> <arc class="consumption" id="cons_064527d3-1c52-4e1b-b3eb-15b4a6a63603" source="mpk1_mpk1_s995_mpk1_mpk1_csa11" target="pr_35bc06f0-6fdd-49de-891a-a2522ee2eeb9_p1"> <start x="2065.5" y="1447.5"/> <next x="2114.1418" y="1449.9718"/> <end x="2119.4773" y="1548.9858"/> </arc> <arc class="production" id="prod_d627b583-8719-415a-9f95-a16f938f824e" source="pr_35bc06f0-6fdd-49de-891a-a2522ee2eeb9_p2" target="mpk1_mpk1_s996_mpk1_mpk1_csa24"> <start x="2119.4773" y="1578.9858"/> <next x="2124.8127" y="1678.0"/> <end x="2087.0" y="1681.5"/> </arc> <arc class="production" id="prod_1a60deaf-d9a6-4fd5-9341-166ae6ab1f63" source="pr_35bc06f0-6fdd-49de-891a-a2522ee2eeb9_p2" target="mpk1_mpk1_s1031_mpk1_mpk1_csa26"> <start x="2119.4773" y="1578.9858"/> <next x="2124.8127" y="1678.0"/> <end x="2116.5" y="1871.0"/> </arc> <arc class="catalysis" id="modif_de6d461f-8dd5-4004-b814-6954ec36aeb6" source="mpk1_mpk1_s183_mpk1_mpk1_sa278" target="pr_35bc06f0-6fdd-49de-891a-a2522ee2eeb9"> <start x="1958.0" y="2267.25"/> <next x="1992.6262" y="2267.0566"/> <next x="1996.0566" y="1788.8524"/> <next x="2100.1545" y="1788.8127"/> <end x="2114.4827" y="1564.2196"/> </arc> <arc class="consumption" id="cons_70e858fc-b160-4b0c-af91-3f4f48699c01" source="mpk1_mpk1_s221_mpk1_mpk1_sa136" target="pr_2a4d9abf-8f77-4f7f-896c-e734fe918d1b_p1"> <start x="1734.5" y="2409.0"/> <end x="1733.25" y="2395.0"/> </arc> <arc class="production" id="prod_3bf5b767-f47e-4b92-8f88-5fa1e96191c4" source="pr_2a4d9abf-8f77-4f7f-896c-e734fe918d1b_p2" target="mpk1_mpk1_s228_mpk1_mpk1_sa137"> <start x="1733.25" y="2365.0"/> <end x="1732.0" y="2351.0"/> </arc> <arc class="catalysis" id="modif_3606fd5f-d726-4d43-9a55-fac3e46ade34" source="mpk1_mpk1_s603_mpk1_mpk1_sa259" target="pr_2a4d9abf-8f77-4f7f-896c-e734fe918d1b"> <start x="2357.1667" y="2605.3335"/> <next x="2370.8848" y="2605.4387"/> <next x="2372.3945" y="2380.275"/> <end x="1738.2454" y="2379.7847"/> </arc> <arc class="consumption" id="cons_d74e961d-ba35-4dca-8241-8dc3216f9c86" source="mpk1_mpk1_s491_mpk1_mpk1_sa279" target="pr_8d239b12-39cc-4f5c-a3b6-391d7f887496_p1"> <start x="1934.0" y="2382.0"/> <end x="1933.5" y="2349.0"/> </arc> <arc class="production" id="prod_cc384598-7f37-40d1-ae9b-321c8a15eb96" source="pr_8d239b12-39cc-4f5c-a3b6-391d7f887496_p2" target="mpk1_mpk1_s183_mpk1_mpk1_sa278"> <start x="1933.5" y="2319.0"/> <end x="1933.0" y="2286.0"/> </arc> <arc class="catalysis" id="modif_76413b08-e579-4932-8845-ddea1ef0875f" source="mpk1_mpk1_s221_mpk1_mpk1_sa136" target="pr_8d239b12-39cc-4f5c-a3b6-391d7f887496"> <start x="1765.0" y="2415.0"/> <next x="1846.18" y="2415.4065"/> <next x="1842.5051" y="2333.3125"/> <end x="1928.5002" y="2334.052"/> </arc> <arc class="consumption" id="cons_d11c6dff-3a41-4d6e-b04d-649ead6c8067" source="mpk1_mpk1_s1032_mpk1_mpk1_csa10" target="pr_9611edec-06da-491e-bc2a-414a49e5642a_p1"> <start x="2246.5" y="1977.75"/> <end x="2076.3762" y="1987.5913"/> </arc> <arc class="production" id="prod_61b8f6f6-e1d9-41ce-93c8-0ab0831971a6" source="pr_9611edec-06da-491e-bc2a-414a49e5642a_p2" target="mpk1_mpk1_s235_mpk1_mpk1_sa147"> <start x="2046.3762" y="1987.5913"/> <next x="1876.2526" y="1997.4325"/> <end x="1908.5" y="1895.5"/> </arc> <arc class="production" id="prod_ac1f6a32-b46d-4d4d-bc70-0b35628194d0" source="pr_9611edec-06da-491e-bc2a-414a49e5642a_p2" target="mpk1_mpk1_s1030_mpk1_mpk1_csa27"> <start x="2046.3762" y="1987.5913"/> <next x="1876.2526" y="1997.4325"/> <end x="1799.0" y="1892.0"/> </arc> <arc class="catalysis" id="modif_02240d40-5159-450a-8f46-03ea19bf6d8e" source="mpk1_mpk1_s991_mpk1_mpk1_csa3" target="pr_9611edec-06da-491e-bc2a-414a49e5642a"> <start x="947.5" y="1760.0"/> <next x="947.13983" y="1782.5615"/> <next x="1523.1033" y="1784.8853"/> <next x="1532.797" y="1976.6917"/> <end x="2056.118" y="1982.8638"/> </arc> <arc class="consumption" id="cons_27ae14b6-52cb-4372-aaed-38b8be1c0525" source="mpk1_mpk1_s1015_mpk1_mpk1_csa19" target="pr_62ff45a0-f2e2-42de-9065-ae979a847099_p1"> <start x="1316.25" y="2685.5"/> <end x="1314.6228" y="2701.5283"/> </arc> <arc class="production" id="prod_ff52dffd-6e27-4fa5-8f8d-ec8e5511b6de" source="pr_62ff45a0-f2e2-42de-9065-ae979a847099_p2" target="mpk1_mpk1_s1014_mpk1_mpk1_csa18"> <start x="1314.6228" y="2731.5283"/> <next x="1312.9955" y="2747.557"/> <next x="1046.6216" y="2750.319"/> <end x="1060.5" y="2683.5"/> </arc> <arc class="production" id="prod_0344063c-552b-410d-adee-3861bdecd84c" source="pr_62ff45a0-f2e2-42de-9065-ae979a847099_p2" target="mpk1_mpk1_s603_mpk1_mpk1_sa259"> <start x="1314.6228" y="2731.5283"/> <next x="1312.9955" y="2747.557"/> <next x="2354.7546" y="2753.3054"/> <end x="2357.1667" y="2617.8335"/> </arc> <arc class="consumption" id="cons_e9755f39-04b9-4d71-a588-f86afcc889b1" source="mpk1_mpk1_s384_mpk1_mpk1_sa22" target="pr_0301db84-5896-442f-9a5e-09176a4f3b15_p1"> <start x="677.5" y="1340.0"/> <next x="669.98175" y="1360.4924"/> <next x="126.0" y="1361.5"/> <end x="149.0" y="1395.0139"/> </arc> <arc class="consumption" id="cons_66191546-04ca-4129-a5c5-b68e099848c9" source="mpk1_mpk1_s274_mpk1_mpk1_sa171" target="pr_0301db84-5896-442f-9a5e-09176a4f3b15_p1"> <start x="236.0" y="1888.0"/> <next x="132.73251" y="1759.8469"/> <next x="126.0" y="1361.5"/> <end x="149.0" y="1395.0139"/> </arc> <arc class="production" id="prod_b5560db8-b257-479c-acb1-dd2055b0bbce" source="pr_0301db84-5896-442f-9a5e-09176a4f3b15_p2" target="mpk1_mpk1_s981_mpk1_mpk1_csa31"> <start x="179.0" y="1395.0139"/> <end x="198.0" y="1425.0"/> </arc> <arc class="inhibition" id="modif_a4bd6c9a-8f0b-480a-a809-58fa7587af39" source="mpk1_mpk1_s983_mpk1_mpk1_csa110" target="pr_0301db84-5896-442f-9a5e-09176a4f3b15"> <start x="560.0" y="1385.0"/> <end x="167.30725" y="1391.2639"/> </arc> <arc class="consumption" id="cons_f2ed85e1-4a6b-40bd-8243-11750f907b5f" source="mpk1_mpk1_s981_mpk1_mpk1_csa31" target="pr_f95c985a-30fb-4ed4-8e47-2746a7c511f3_p1"> <start x="198.0" y="1447.0"/> <next x="148.0" y="1447.0"/> <next x="148.0" y="1530.75"/> <next x="148.0" y="1530.75"/> <next x="148.0" y="1577.5"/> <end x="164.0" y="1577.5"/> </arc> <arc class="consumption" id="cons_a87fd763-cffb-404e-b28e-038627bf07da" source="mpk1_mpk1_s275_mpk1_mpk1_sa166" target="pr_f95c985a-30fb-4ed4-8e47-2746a7c511f3_p1"> <start x="255.0" y="1845.5"/> <next x="151.0" y="1761.25"/> <next x="148.0" y="1577.5"/> <end x="164.0" y="1577.5"/> </arc> <arc class="production" id="prod_6a15c65b-b3a5-4d12-b8f4-d7e32b3b673c" source="pr_f95c985a-30fb-4ed4-8e47-2746a7c511f3_p2" target="mpk1_mpk1_s987_mpk1_mpk1_csa32"> <start x="194.0" y="1577.5"/> <next x="206.0" y="1577.5"/> <next x="206.0" y="1578.5"/> <end x="215.0" y="1578.5"/> </arc> <arc class="consumption" id="cons_d1420ed2-df24-4a34-8518-fb50b59785a3" source="mpk1_mpk1_s279_mpk1_mpk1_sa170" target="pr_dcea8094-ebf0-47b9-a11d-d941f02479be_p1"> <start x="269.3358" y="2001.7836"/> <end x="299.55096" y="1972.7495"/> </arc> <arc class="production" id="prod_c51ef0cf-d0b9-41c1-8afb-6ac9d91804cd" source="pr_dcea8094-ebf0-47b9-a11d-d941f02479be_p2" target="mpk1_mpk1_s488_mpk1_mpk1_sa275"> <start x="329.55096" y="1972.7495"/> <end x="359.76614" y="1943.7155"/> </arc> <arc class="consumption" id="cons_1f7378a0-0b21-473a-8db9-14990bc6d8b1" source="mpk1_mpk1_s276_mpk1_mpk1_sa167" target="pr_f2efd951-dc0c-406e-893f-4ec816de8262_p1"> <start x="282.0" y="1727.0"/> <end x="307.5" y="1726.7617"/> </arc> <arc class="production" id="prod_c9cca12b-2296-49c8-8426-345f68955135" source="pr_f2efd951-dc0c-406e-893f-4ec816de8262_p2" target="mpk1_mpk1_s279_mpk1_mpk1_sa170"> <start x="337.5" y="1726.7617"/> <next x="363.0" y="1726.5236"/> <end x="250.39392" y="1985.4515"/> </arc> <arc class="production" id="prod_361f6c90-9a82-419b-96c1-b9f08bbbd40e" source="pr_f2efd951-dc0c-406e-893f-4ec816de8262_p2" target="mpk1_mpk1_s278_mpk1_mpk1_sa169"> <start x="337.5" y="1726.7617"/> <next x="363.0" y="1726.5236"/> <end x="365.0" y="1678.5"/> </arc> <arc class="catalysis" id="modif_7f1dd522-6962-4318-8d76-d19ba349574a" source="mpk1_mpk1_s987_mpk1_mpk1_csa32" target="pr_f2efd951-dc0c-406e-893f-4ec816de8262"> <start x="271.5" y="1636.0"/> <end x="327.47052" y="1721.7324"/> </arc> <arc class="consumption" id="cons_7352007f-19d9-4bb1-b97f-e8e15ab115d4" source="mpk1_mpk1_s278_mpk1_mpk1_sa169" target="pr_f5ab3ffa-770b-4333-b517-5a8eb2bd99c9_p1"> <start x="389.74875" y="1674.8389"/> <next x="406.39392" y="1692.0"/> <end x="405.55585" y="1603.0"/> </arc> <arc class="consumption" id="cons_07371ad6-4f38-44f8-857d-4950f8a38a70" source="mpk1_mpk1_s257_mpk1_mpk1_sa158" target="pr_f5ab3ffa-770b-4333-b517-5a8eb2bd99c9_p1"> <start x="359.0" y="1852.0"/> <next x="406.39392" y="1692.0"/> <end x="405.55585" y="1603.0"/> </arc> <arc class="production" id="prod_f6794f51-6b64-4728-a94d-9351f5cbfe4b" source="pr_f5ab3ffa-770b-4333-b517-5a8eb2bd99c9_p2" target="mpk1_mpk1_s982_mpk1_mpk1_csa33"> <start x="405.55585" y="1573.0"/> <end x="404.75" y="1488.0"/> </arc> <arc class="consumption" id="cons_afa3ea57-ba1a-4f81-a964-39a5a615d6c6" source="mpk1_mpk1_s982_mpk1_mpk1_csa33" target="pr_1fc8c650-7d20-4bbd-9ee4-684a8c49be17_p1"> <start x="430.5" y="1488.0"/> <next x="430.0" y="1710.5"/> <next x="480.16223" y="1660.3497"/> <end x="482.45612" y="1641.4248"/> </arc> <arc class="consumption" id="cons_fcac4d13-29da-4e45-9b15-83dbcacc1bb7" source="mpk1_mpk1_s488_mpk1_mpk1_sa275" target="pr_1fc8c650-7d20-4bbd-9ee4-684a8c49be17_p1"> <start x="399.6163" y="1918.8907"/> <next x="430.0" y="1710.5"/> <next x="480.16223" y="1660.3497"/> <end x="482.45612" y="1641.4248"/> </arc> <arc class="production" id="prod_32cedcf1-31c4-41b6-82c1-e701eabb9830" source="pr_1fc8c650-7d20-4bbd-9ee4-684a8c49be17_p2" target="mpk1_mpk1_s988_mpk1_mpk1_csa34"> <start x="482.45612" y="1611.4248"/> <end x="484.75" y="1592.5"/> </arc> <arc class="consumption" id="cons_a9678beb-0029-4fa6-82db-8200ee140316" source="mpk1_mpk1_s988_mpk1_mpk1_csa34" target="pr_675b73d8-9937-474f-b9b0-c631c83426bc_p1"> <start x="520.0" y="1592.5"/> <end x="493.0" y="1848.75"/> </arc> <arc class="production" id="prod_87c3be2f-e366-4a47-a13d-34b32f40c594" source="pr_675b73d8-9937-474f-b9b0-c631c83426bc_p2" target="mpk1_mpk1_s1001_mpk1_mpk1_csa35"> <start x="493.0" y="1878.75"/> <end x="466.0" y="2135.0"/> </arc> <arc class="consumption" id="cons_6755eff5-2c08-45e4-a805-2c04a73f6c29" source="mpk1_mpk1_s302_mpk1_mpk1_sa186" target="pr_cac1927c-b71d-4c07-a4a9-ccef29691b8d_p1"> <start x="550.0" y="1907.5"/> <end x="550.0" y="1845.0"/> </arc> <arc class="production" id="prod_f2bbadb6-206c-4720-9775-62a9bbb1c566" source="pr_cac1927c-b71d-4c07-a4a9-ccef29691b8d_p2" target="mpk1_mpk1_s303_mpk1_mpk1_sa188"> <start x="550.0" y="1815.0"/> <end x="550.0" y="1752.5"/> </arc> <arc class="catalysis" id="modif_ede26a38-7f60-46cd-af6b-d0ce7720bb27" source="mpk1_mpk1_s488_mpk1_mpk1_sa275" target="pr_cac1927c-b71d-4c07-a4a9-ccef29691b8d"> <start x="416.12277" y="1929.1735"/> <next x="483.29495" y="1832.3354"/> <end x="545.0" y="1830.0"/> </arc> <arc class="consumption" id="cons_5e189921-022f-45de-a339-a8f9d2beba9d" source="mpk1_mpk1_s358_mpk1_mpk1_sa240" target="pr_9166f41f-4373-4820-ba02-77d878373af6_p1"> <start x="793.5" y="2215.0"/> <next x="797.77185" y="2407.5764"/> <next x="449.5" y="2403.25"/> <end x="382.25" y="2465.642"/> </arc> <arc class="consumption" id="cons_9772fcb4-8923-4a6b-b36a-9d0d478221c4" source="mpk1_mpk1_s1002_mpk1_mpk1_csa37" target="pr_9166f41f-4373-4820-ba02-77d878373af6_p1"> <start x="278.0" y="2391.5"/> <next x="274.54318" y="2402.4338"/> <next x="449.5" y="2403.25"/> <end x="382.25" y="2465.642"/> </arc> <arc class="production" id="prod_3533576f-616c-4276-bc63-3affe01d3318" source="pr_9166f41f-4373-4820-ba02-77d878373af6_p2" target="mpk1_mpk1_s1003_mpk1_mpk1_csa38"> <start x="352.25" y="2465.642"/> <end x="289.0" y="2525.0"/> </arc> <arc class="catalysis" id="modif_9f79e1c5-cff9-41bd-af9a-5953627f8293" source="mpk1_mpk1_s230_mpk1_mpk1_sa144" target="pr_9166f41f-4373-4820-ba02-77d878373af6"> <start x="1690.0" y="2218.5"/> <next x="860.5363" y="2204.3328"/> <next x="864.3481" y="2419.2063"/> <next x="368.83215" y="2417.1028"/> <end x="368.21176" y="2458.6367"/> </arc> <arc class="consumption" id="cons_d72f1dd1-a2c2-4624-b659-d9ff9fb1c4a3" source="mpk1_mpk1_s327_mpk1_mpk1_sa264" target="pr_35a53ddf-9cda-4049-a0e0-6c163e0c5783_p1"> <start x="1997.5" y="2542.5"/> <next x="1955.9254" y="2767.5935"/> <next x="600.3092" y="2767.2659"/> <next x="598.0" y="2353.1816"/> <end x="552.5" y="2396.0063"/> </arc> <arc class="consumption" id="cons_4a8c4f65-0f19-472f-a9e0-f5dbf25f3ecd" source="mpk1_mpk1_s174_mpk1_mpk1_sa64" target="pr_35a53ddf-9cda-4049-a0e0-6c163e0c5783_p1"> <start x="2127.5" y="2617.0"/> <next x="2125.85" y="2767.9673"/> <next x="599.0172" y="2765.936"/> <next x="598.0" y="2353.1816"/> <end x="552.5" y="2396.0063"/> </arc> <arc class="production" id="prod_7d104876-3eb1-4cdc-abff-4a50547a8df0" source="pr_35a53ddf-9cda-4049-a0e0-6c163e0c5783_p2" target="mpk1_mpk1_s1004_mpk1_mpk1_csa41"> <start x="522.5" y="2396.0063"/> <end x="481.0" y="2436.0"/> </arc> <arc class="consumption" id="addreact_06c3cc02-ef6a-41e1-a9f2-95a69d0835cd" source="mpk1_mpk1_s609_mpk1_mpk1_sa214" target="pr_35a53ddf-9cda-4049-a0e0-6c163e0c5783_p1"> <start x="522.0" y="2317.75"/> <end x="552.5" y="2396.0063"/> </arc> <arc class="consumption" id="cons_696c4718-7f31-413c-a273-50c1e241061b" source="mpk1_mpk1_s1004_mpk1_mpk1_csa41" target="pr_5994abe0-7c17-4d1b-9599-5947c837a1a4_p1"> <start x="537.0" y="2501.25"/> <end x="592.0" y="2501.5"/> </arc> <arc class="production" id="prod_553ded76-e0a0-4586-a207-50e611985350" source="pr_5994abe0-7c17-4d1b-9599-5947c837a1a4_p2" target="mpk1_mpk1_s1005_mpk1_mpk1_csa43"> <start x="622.0" y="2501.5"/> <end x="677.0" y="2501.75"/> </arc> <arc class="catalysis" id="modif_21b9eaa3-a0c9-4d81-9dd9-705d5efc283e" source="mpk1_mpk1_s1003_mpk1_mpk1_csa38" target="pr_5994abe0-7c17-4d1b-9599-5947c837a1a4"> <start x="402.0" y="2570.0"/> <next x="609.9144" y="2570.2168"/> <end x="606.9821" y="2506.5"/> </arc> <arc class="consumption" id="cons_4a8cc5ea-bc98-4bea-9762-8649afbb7b5b" source="mpk1_mpk1_s997_mpk1_mpk1_csa64" target="pr_bdddd665-fb97-4c90-9556-936a2acea9ca_p1"> <start x="2197.0" y="1495.0"/> <next x="2192.0" y="1638.0"/> <end x="2197.0" y="1638.8333"/> </arc> <arc class="consumption" id="cons_40069496-9e0b-497f-a880-e459cb6577ea" source="mpk1_mpk1_s360_mpk1_mpk1_sa236" target="pr_bdddd665-fb97-4c90-9556-936a2acea9ca_p1"> <start x="2539.5" y="1918.0"/> <next x="2538.8413" y="1886.0802"/> <next x="2208.1704" y="1884.3544"/> <next x="2192.0" y="1638.0"/> <end x="2197.0" y="1638.8333"/> </arc> <arc class="production" id="prod_594145c7-e0da-434b-ad99-8d468f5b1557" source="pr_bdddd665-fb97-4c90-9556-936a2acea9ca_p2" target="mpk1_mpk1_s998_mpk1_mpk1_csa46"> <start x="2227.0" y="1638.8333"/> <end x="2228.0" y="1639.5"/> </arc> <arc class="consumption" id="cons_f43dad33-676d-49b1-8410-12eb9724d72f" source="mpk1_mpk1_s998_mpk1_mpk1_csa46" target="pr_3876f6c1-a897-4f20-b0e4-d08dd4c4d06d_p1"> <start x="2292.5" y="1719.0"/> <next x="2293.3286" y="1809.0677"/> <next x="1553.7039" y="1807.6332"/> <next x="1555.0391" y="2054.0837"/> <next x="1329.0" y="2169.7046"/> <end x="1664.5728" y="2172.7935"/> </arc> <arc class="consumption" id="cons_d4aaa6de-b87b-4d27-8a3b-b8d68c5803be" source="mpk1_mpk1_s358_mpk1_mpk1_sa240" target="pr_3876f6c1-a897-4f20-b0e4-d08dd4c4d06d_p1"> <start x="826.5" y="2189.0"/> <next x="827.0115" y="2172.3972"/> <next x="1329.0" y="2169.7046"/> <end x="1664.5728" y="2172.7935"/> </arc> <arc class="production" id="prod_866710c4-922d-43d7-b333-d13022c7b109" source="pr_3876f6c1-a897-4f20-b0e4-d08dd4c4d06d_p2" target="mpk1_mpk1_s1018_mpk1_mpk1_csa44"> <start x="1694.5728" y="2172.7935"/> <next x="2026.1456" y="2175.8472"/> <next x="2022.056" y="2050.579"/> <next x="2586.01" y="2048.141"/> <end x="2585.0" y="2080.0"/> </arc> <arc class="catalysis" id="modif_c9ce4cbd-cbcb-46ab-b3f2-234bf6b788f2" source="mpk1_mpk1_s230_mpk1_mpk1_sa144" target="pr_3876f6c1-a897-4f20-b0e4-d08dd4c4d06d"> <start x="1715.0" y="2206.0"/> <end x="1679.5287" y="2177.7932"/> </arc> <arc class="consumption" id="addreact_7e78b1f5-9d96-4957-8a36-f47bbd4795b6" source="mpk1_mpk1_s174_mpk1_mpk1_sa64" target="pr_3876f6c1-a897-4f20-b0e4-d08dd4c4d06d_p1"> <start x="2140.0" y="2592.0"/> <end x="1664.5728" y="2172.7935"/> </arc> <arc class="consumption" id="addreact_fdd73b43-c400-4667-807e-0a6e3904a705" source="mpk1_mpk1_s327_mpk1_mpk1_sa264" target="pr_3876f6c1-a897-4f20-b0e4-d08dd4c4d06d_p1"> <start x="1997.5" y="2517.5"/> <end x="1664.5728" y="2172.7935"/> </arc> <arc class="consumption" id="cons_ec0cb64e-c8ff-4b11-8616-01801c96d539" source="mpk1_mpk1_s603_mpk1_mpk1_sa259" target="pr_b78dd64f-1288-4f58-bda7-94532787d94b_p1"> <start x="2344.6667" y="2617.8335"/> <end x="2343.2668" y="2700.9272"/> </arc> <arc class="production" id="prod_51565e0b-9da1-4baa-a5a0-d0288e10fd08" source="pr_b78dd64f-1288-4f58-bda7-94532787d94b_p2" target="mpk1_mpk1_s387_mpk1_mpk1_sa260"> <start x="2343.2668" y="2730.9272"/> <next x="2341.867" y="2814.0208"/> <next x="782.6688" y="2827.0903"/> <end x="792.1667" y="2884.5"/> </arc> <arc class="catalysis" id="modif_7c4c575e-55cb-412b-af60-e35f122f9560" source="mpk1_mpk1_s665_mpk1_mpk1_sa396" target="pr_b78dd64f-1288-4f58-bda7-94532787d94b"> <start x="3927.4963" y="2649.0"/> <next x="3929.911" y="2693.8792"/> <end x="2348.2664" y="2715.9985"/> </arc> <arc class="consumption" id="cons_8d5bef44-dbcf-4fea-9f0b-e157cb1709c2" source="mpk1_mpk1_s991_mpk1_mpk1_csa3" target="pr_6c8548bd-0e37-4bb4-8177-ecf7e642c1c7_p1"> <start x="911.75" y="1657.0"/> <end x="877.375" y="1616.1545"/> </arc> <arc class="production" id="prod_02f16c2d-0adb-46bc-b771-da562f946305" source="pr_6c8548bd-0e37-4bb4-8177-ecf7e642c1c7_p2" target="mpk1_mpk1_s25_mpk1_mpk1_sa28"> <start x="847.375" y="1616.1545"/> <next x="813.0" y="1575.309"/> <end x="737.5" y="1734.0"/> </arc> <arc class="production" id="prod_aa4f7ae5-b53b-43a3-b081-27f42fd74c54" source="pr_6c8548bd-0e37-4bb4-8177-ecf7e642c1c7_p2" target="mpk1_mpk1_s989_mpk1_mpk1_csa6"> <start x="847.375" y="1616.1545"/> <next x="813.0" y="1575.309"/> <end x="818.25" y="1491.0"/> </arc> <arc class="catalysis" id="modif_284d9dca-2852-4a39-90d3-da39373a6692" source="mpk1_mpk1_s303_mpk1_mpk1_sa188" target="pr_6c8548bd-0e37-4bb4-8177-ecf7e642c1c7"> <start x="575.0" y="1727.5"/> <next x="654.8776" y="1610.9158"/> <end x="855.3353" y="1616.8201"/> </arc> <arc class="consumption" id="cons_f5f8e26b-f090-4c32-996b-ff43f8913b4b" source="mpk1_mpk1_s994_mpk1_mpk1_csa12" target="pr_d6400353-6d10-445e-9867-52ccc980c632_p1"> <start x="1677.5" y="1763.5"/> <end x="1673.25" y="1761.9314"/> </arc> <arc class="production" id="prod_7fde3630-3fd9-4e69-8ecd-3f1732342dbb" source="pr_d6400353-6d10-445e-9867-52ccc980c632_p2" target="mpk1_mpk1_s1033_mpk1_mpk1_csa61"> <start x="1703.25" y="1761.9314"/> <next x="1699.0" y="1760.3629"/> <next x="1703.7678" y="1785.9916"/> <next x="1650.4207" y="1785.0183"/> <end x="1657.0" y="2034.0"/> </arc> <arc class="production" id="prod_2a7f810a-87d5-47f5-b899-a50f6aa76de9" source="pr_d6400353-6d10-445e-9867-52ccc980c632_p2" target="mpk1_mpk1_s993_mpk1_mpk1_csa4"> <start x="1703.25" y="1761.9314"/> <next x="1699.0" y="1760.3629"/> <next x="1700.0929" y="1541.0942"/> <end x="1619.0" y="1540.0"/> </arc> <arc class="consumption" id="cons_67ebbc04-a5e0-4fd6-871a-34938c6076d0" source="mpk1_mpk1_s522_mpk1_mpk1_sa301" target="pr_c1e31861-264b-4751-9ddd-4477a7916204_p1"> <start x="2047.0" y="2313.0"/> <end x="2091.3335" y="2316.6667"/> </arc> <arc class="production" id="prod_3702459c-916f-4be0-9b85-72da4fd1a428" source="pr_c1e31861-264b-4751-9ddd-4477a7916204_p2" target="mpk1_mpk1_s523_mpk1_mpk1_sa302"> <start x="2121.3335" y="2316.6667"/> <end x="2165.6667" y="2320.3335"/> </arc> <arc class="catalysis" id="modif_b1a0bee6-acc2-43b0-96ac-44d9272008ce" source="mpk1_mpk1_s1034_mpk1_mpk1_csa62" target="pr_c1e31861-264b-4751-9ddd-4477a7916204"> <start x="1969.0" y="2114.0"/> <next x="2103.9285" y="2115.606"/> <end x="2106.6418" y="2311.6763"/> </arc> <arc class="consumption" id="cons_63fd6fe3-4bcd-40b4-9ca0-496b00bed106" source="mpk1_mpk1_s1033_mpk1_mpk1_csa61" target="pr_3a7b1808-3305-484c-90ce-9066e7810c8d_p1"> <start x="1759.0" y="2144.0"/> <next x="1781.5" y="2142.0"/> <end x="1795.25" y="2142.0"/> </arc> <arc class="consumption" id="cons_e41d6d73-8236-4ad7-9f3d-e5751195aa44" source="mpk1_mpk1_s603_mpk1_mpk1_sa259" target="pr_3a7b1808-3305-484c-90ce-9066e7810c8d_p1"> <start x="2344.6667" y="2592.8335"/> <next x="2344.078" y="2550.8315"/> <next x="1775.0214" y="2557.9749"/> <next x="1781.5" y="2142.0"/> <end x="1795.25" y="2142.0"/> </arc> <arc class="production" id="prod_5cd54910-5912-4616-abbb-8e9b0006d056" source="pr_3a7b1808-3305-484c-90ce-9066e7810c8d_p2" target="mpk1_mpk1_s1034_mpk1_mpk1_csa62"> <start x="1825.25" y="2142.0"/> <end x="1835.0" y="2142.0"/> </arc> <arc class="consumption" id="cons_8c25edbc-dc0b-49e3-8ac4-83ad27c9390b" source="mpk1_mpk1_s1005_mpk1_mpk1_csa43" target="pr_3f582c0c-5232-4f38-b8ea-73a622240f2e_p1"> <start x="803.0" y="2480.0"/> <next x="889.79346" y="2482.1384"/> <next x="890.0" y="2640.0"/> <end x="869.5" y="2635.8936"/> </arc> <arc class="consumption" id="cons_980f5283-1ceb-4a03-be92-3f698fbf255e" source="mpk1_mpk1_s603_mpk1_mpk1_sa259" target="pr_3f582c0c-5232-4f38-b8ea-73a622240f2e_p1"> <start x="2332.1667" y="2617.8335"/> <next x="2329.6006" y="2839.5935"/> <next x="890.0" y="2840.0"/> <next x="890.0" y="2640.0"/> <end x="869.5" y="2635.8936"/> </arc> <arc class="production" id="prod_787d4631-f453-48c7-aa32-a2dff76557b6" source="pr_3f582c0c-5232-4f38-b8ea-73a622240f2e_p2" target="mpk1_mpk1_s1006_mpk1_mpk1_csa63"> <start x="839.5" y="2635.8936"/> <end x="823.0" y="2632.25"/> </arc> <arc class="consumption" id="cons_5ebe91d8-fcf0-4b2c-80d6-32ff179d1638" source="mpk1_mpk1_s347_mpk1_mpk1_sa225" target="pr_0ff89576-b546-4d17-bd27-e58037f80c1b_p1"> <start x="2147.0" y="1340.0"/> <next x="2143.0" y="1454.0"/> <end x="2157.0" y="1454.2686"/> </arc> <arc class="consumption" id="cons_31cfbc62-25c9-4d7b-abe0-b911e9e1229e" source="mpk1_mpk1_s536_mpk1_mpk1_sa311" target="pr_0ff89576-b546-4d17-bd27-e58037f80c1b_p1"> <start x="2156.0" y="1837.0"/> <next x="2143.0" y="1454.0"/> <end x="2157.0" y="1454.2686"/> </arc> <arc class="production" id="prod_7bfe8509-2671-43c3-a8e5-0d01d43dabf9" source="pr_0ff89576-b546-4d17-bd27-e58037f80c1b_p2" target="mpk1_mpk1_s997_mpk1_mpk1_csa64"> <start x="2187.0" y="1454.2686"/> <end x="2197.0" y="1454.5"/> </arc> <arc class="consumption" id="cons_48435bb7-9e54-4d55-bfb9-96c1ad55ef17" source="mpk1_mpk1_s1018_mpk1_mpk1_csa44" target="pr_f8548cf2-6680-4a86-b063-9d05ea3cc38c_p1"> <start x="2526.5" y="2240.0"/> <next x="2526.8274" y="2252.4553"/> <next x="2206.8843" y="2253.0103"/> <next x="2207.5364" y="2190.4724"/> <end x="2199.018" y="2201.3142"/> </arc> <arc class="production" id="prod_23cad3b5-9dd6-48f7-a627-c1341150a310" source="pr_f8548cf2-6680-4a86-b063-9d05ea3cc38c_p2" target="mpk1_mpk1_s1029_mpk1_mpk1_csa65"> <start x="2169.018" y="2201.3142"/> <next x="2160.5" y="2212.156"/> <end x="2156.0" y="2185.0"/> </arc> <arc class="production" id="prod_f2b98ce9-ceb8-4142-8ef2-334badf4324b" source="pr_f8548cf2-6680-4a86-b063-9d05ea3cc38c_p2" target="mpk1_mpk1_s984_mpk1_mpk1_csa66"> <start x="2169.018" y="2201.3142"/> <next x="2160.5" y="2212.156"/> <next x="2153.907" y="2266.3901"/> <next x="2371.9573" y="2265.3403"/> <end x="2372.0" y="2241.0"/> </arc> <arc class="production" id="addprod_626babc9-3a4f-484e-91c4-6b1a3f63d459" source="pr_f8548cf2-6680-4a86-b063-9d05ea3cc38c_p2" target="mpk1_mpk1_s358_mpk1_mpk1_sa240"> <start x="2169.018" y="2201.3142"/> <end x="843.0" y="2195.5"/> </arc> <arc class="consumption" id="cons_a73cd522-5771-4dbe-99a2-af1023068a29" source="mpk1_mpk1_s984_mpk1_mpk1_csa66" target="pr_9a4b50a0-ef64-41ed-aa22-2099d1400f3d_p1"> <start x="2408.5" y="2241.0"/> <next x="2409.187" y="2292.2368"/> <next x="2379.208" y="2292.7974"/> <next x="2380.0" y="2466.5"/> <end x="2405.974" y="2467.7678"/> </arc> <arc class="consumption" id="cons_7c29c489-87a5-4bc7-bcf4-a9290e8386f4" source="mpk1_mpk1_s603_mpk1_mpk1_sa259" target="pr_9a4b50a0-ef64-41ed-aa22-2099d1400f3d_p1"> <start x="2357.1667" y="2599.0835"/> <next x="2379.4954" y="2599.212"/> <next x="2380.0" y="2466.5"/> <end x="2405.974" y="2467.7678"/> </arc> <arc class="production" id="prod_f39e6240-9869-475d-ac7b-e04c82fa669f" source="pr_9a4b50a0-ef64-41ed-aa22-2099d1400f3d_p2" target="mpk1_mpk1_s985_mpk1_mpk1_csa67"> <start x="2435.974" y="2467.7678"/> <next x="2457.9482" y="2468.9119"/> <end x="2459.0" y="2422.0"/> </arc> <arc class="consumption" id="cons_a0891169-a027-4678-af67-57f7991470b9" source="mpk1_mpk1_s603_mpk1_mpk1_sa259" target="pr_e1098099-ccd8-4c49-b84d-47c3381e4f3f_p1"> <start x="2332.1667" y="2592.8335"/> <next x="2335.0" y="2534.0"/> <end x="2288.624" y="2534.755"/> </arc> <arc class="consumption" id="cons_6ae61b44-30a3-4f12-b963-52847c5d68f9" source="mpk1_mpk1_s367_mpk1_mpk1_sa245" target="pr_e1098099-ccd8-4c49-b84d-47c3381e4f3f_p1"> <start x="2333.0" y="2502.0"/> <next x="2335.0" y="2534.0"/> <end x="2288.624" y="2534.755"/> </arc> <arc class="production" id="prod_36a5e726-ef78-4209-9fcf-605112a53f10" source="pr_e1098099-ccd8-4c49-b84d-47c3381e4f3f_p2" target="mpk1_mpk1_s1017_mpk1_mpk1_csa49"> <start x="2258.624" y="2534.755"/> <next x="2216.2483" y="2535.4607"/> <end x="2183.0" y="2503.5"/> </arc> <arc class="consumption" id="cons_9129ce4c-8946-4376-929d-77f66163e144" source="mpk1_mpk1_s239_mpk1_mpk1_sa150" target="pr_d54bc8f1-7a88-462b-b10d-89cdaad7fdbe_p1"> <start x="1403.5" y="2900.0"/> <end x="1403.25" y="2968.0"/> </arc> <arc class="production" id="prod_3c8bf6e4-8660-4cba-9ab6-a29471c7dc44" source="pr_d54bc8f1-7a88-462b-b10d-89cdaad7fdbe_p2" target="mpk1_mpk1_s377_mpk1_mpk1_sa251"> <start x="1403.25" y="2998.0"/> <end x="1403.0" y="3066.0"/> </arc> <arc class="catalysis" id="modif_d83e6633-0e68-4706-b87d-f4e10a80c686" source="mpk1_mpk1_s387_mpk1_mpk1_sa260" target="pr_d54bc8f1-7a88-462b-b10d-89cdaad7fdbe"> <start x="825.1667" y="2897.5"/> <end x="1398.25" y="2982.9849"/> </arc> <arc class="catalysis" id="modif_e0f58b83-232b-40bb-87e4-91862fdf755a" source="mpk1_mpk1_s795_mpk1_mpk1_sa550" target="pr_d54bc8f1-7a88-462b-b10d-89cdaad7fdbe"> <start x="2950.2144" y="2938.2856"/> <next x="2728.9524" y="3184.6167"/> <next x="1493.8926" y="3183.6416"/> <end x="1408.2349" y="2988.0151"/> </arc> <arc class="catalysis" id="modif_0fb7b1bd-3fd3-4779-828e-faa303853c59" source="mpk1_mpk1_s796_mpk1_mpk1_sa551" target="pr_d54bc8f1-7a88-462b-b10d-89cdaad7fdbe"> <start x="2348.5715" y="2906.6428"/> <next x="2307.234" y="2907.2073"/> <next x="2302.9326" y="3178.7937"/> <next x="1511.9944" y="3180.0283"/> <end x="1408.265" y="2978.0151"/> </arc> <arc class="consumption" id="cons_39969669-e23a-486c-add5-e88e87756839" source="mpk1_mpk1_s387_mpk1_mpk1_sa260" target="pr_b67ad3b7-1ad0-4736-96e4-f7d8ede3b199_p1"> <start x="775.6667" y="2910.5"/> <next x="799.5" y="2980.625"/> <end x="773.25586" y="3007.8125"/> </arc> <arc class="consumption" id="cons_b539449c-f892-4c3b-a9d3-03803a59b0b7" source="mpk1_mpk1_s371_mpk1_mpk1_sa248" target="pr_b67ad3b7-1ad0-4736-96e4-f7d8ede3b199_p1"> <start x="918.5" y="2993.0"/> <next x="799.5" y="2980.625"/> <end x="773.25586" y="3007.8125"/> </arc> <arc class="production" id="prod_452ab886-b805-4b5a-8e56-9d3b659901df" source="pr_b67ad3b7-1ad0-4736-96e4-f7d8ede3b199_p2" target="mpk1_mpk1_s1020_mpk1_mpk1_csa48"> <start x="773.25586" y="3037.8125"/> <end x="749.5" y="3061.0"/> </arc> <arc class="consumption" id="cons_0789592e-8727-497b-a5e0-a1189c0903a0" source="mpk1_mpk1_s516_mpk1_mpk1_sa295" target="pr_97118bc7-1386-4ee6-8344-b91ad2383358_p1"> <start x="1848.0" y="2655.0"/> <end x="1847.75" y="2666.8333"/> </arc> <arc class="production" id="prod_abf17857-8c7c-407f-a942-45cf070b5464" source="pr_97118bc7-1386-4ee6-8344-b91ad2383358_p2" target="mpk1_mpk1_s604_mpk1_mpk1_sa326"> <start x="1847.75" y="2696.8333"/> <end x="1847.5" y="2708.6665"/> </arc> <arc class="catalysis" id="modif_a56bef3c-b706-4c49-9e93-ef6dbba378b5" source="mpk1_mpk1_s1006_mpk1_mpk1_csa63" target="pr_97118bc7-1386-4ee6-8344-b91ad2383358"> <start x="823.0" y="2587.75"/> <next x="862.1745" y="2589.429"/> <next x="863.076" y="2756.5034"/> <next x="1903.2147" y="2760.4744"/> <next x="1904.841" y="2681.71"/> <end x="1852.7498" y="2681.88"/> </arc> <arc class="catalysis" id="modif_47b0bce9-d621-4a45-a62c-d284d0745762" source="mpk1_mpk1_s985_mpk1_mpk1_csa67" target="pr_97118bc7-1386-4ee6-8344-b91ad2383358"> <start x="2494.0" y="2422.0"/> <next x="2498.4062" y="2705.0212"/> <next x="1943.9546" y="2703.714"/> <next x="1943.8754" y="2675.6755"/> <end x="1852.7964" y="2676.8801"/> </arc> <arc class="consumption" id="cons_205fae10-fc9c-4add-9c95-a05c6b943338" source="mpk1_mpk1_s560_mpk1_mpk1_sa327" target="pr_66078d37-0fd5-499b-badd-ff7bfb3d9924_p1"> <start x="519.0" y="2896.0"/> <end x="520.5833" y="2915.3333"/> </arc> <arc class="production" id="prod_0fa0fd4f-db30-4a7e-8d59-713f19aa6749" source="pr_66078d37-0fd5-499b-badd-ff7bfb3d9924_p2" target="mpk1_mpk1_s561_mpk1_mpk1_sa328"> <start x="520.5833" y="2945.3333"/> <end x="522.1666" y="2964.6665"/> </arc> <arc class="catalysis" id="modif_c1c55167-7ade-402b-bbf5-12d06b3e5a2e" source="mpk1_mpk1_s387_mpk1_mpk1_sa260" target="pr_66078d37-0fd5-499b-badd-ff7bfb3d9924"> <start x="759.1667" y="2897.5"/> <end x="525.578" y="2930.103"/> </arc> <arc class="catalysis" id="modif_078d189b-01d2-484f-97e0-37ccff82dc50" source="mpk1_mpk1_s795_mpk1_mpk1_sa550" target="pr_66078d37-0fd5-499b-badd-ff7bfb3d9924"> <start x="2975.2144" y="2938.2856"/> <next x="2977.0574" y="3174.5012"/> <next x="673.97705" y="3177.579"/> <next x="673.9887" y="2933.8196"/> <end x="525.80835" y="2935.0977"/> </arc> <arc class="consumption" id="cons_5b2e354b-c458-4a11-80fd-7b19371d18d8" source="mpk1_mpk1_s562_mpk1_mpk1_sa329" target="pr_c0933e25-eae5-4cb1-ac44-a8dccedcab1f_p1"> <start x="604.0" y="3045.0"/> <end x="570.6667" y="3072.0"/> </arc> <arc class="production" id="prod_3d0f723e-a493-4084-8162-61b23a15cb89" source="pr_c0933e25-eae5-4cb1-ac44-a8dccedcab1f_p2" target="mpk1_mpk1_s563_mpk1_mpk1_sa330"> <start x="570.6667" y="3102.0"/> <end x="537.3334" y="3129.0"/> </arc> <arc class="catalysis" id="modif_b33f269c-26d3-436b-abe7-84b69fa36c12" source="mpk1_mpk1_s561_mpk1_mpk1_sa328" target="pr_c0933e25-eae5-4cb1-ac44-a8dccedcab1f"> <start x="522.1666" y="2989.6665"/> <end x="566.75024" y="3083.8916"/> </arc> <arc class="consumption" id="cons_b61db16b-66c5-4875-b2ec-3544585c60b1" source="mpk1_mpk1_s604_mpk1_mpk1_sa326" target="pr_9f72dfec-2cf3-4f06-a9ab-9f4c012b19a8_p1"> <start x="1847.5" y="2733.6665"/> <next x="1846.0828" y="2833.808"/> <end x="1589.4937" y="2834.6309"/> </arc> <arc class="production" id="prod_fdc53b0e-df76-42a3-9de5-f5108479d75c" source="pr_9f72dfec-2cf3-4f06-a9ab-9f4c012b19a8_p2" target="mpk1_mpk1_s558_mpk1_mpk1_sa325"> <start x="1559.4937" y="2834.6309"/> <next x="1302.9045" y="2835.4534"/> <end x="1303.1666" y="2873.3335"/> </arc> <arc class="consumption" id="cons_f2b746ea-5e7a-4968-a4a3-358bac6a44cd" source="mpk1_mpk1_s358_mpk1_mpk1_sa240" target="pr_c0840ce2-9fa7-41c8-84e2-68fd219337d3_p1"> <start x="810.0" y="2189.0"/> <next x="800.0" y="1870.0"/> <end x="962.0" y="1780.9943"/> </arc> <arc class="consumption" id="cons_bd4389b5-5218-4a3c-94b1-25dcf13d6e27" source="mpk1_mpk1_s991_mpk1_mpk1_csa3" target="pr_c0840ce2-9fa7-41c8-84e2-68fd219337d3_p1"> <start x="911.75" y="1760.0"/> <next x="800.0" y="1870.0"/> <end x="962.0" y="1780.9943"/> </arc> <arc class="production" id="prod_53ed5517-cb87-44ec-bb30-9867772b29f3" source="pr_c0840ce2-9fa7-41c8-84e2-68fd219337d3_p2" target="mpk1_mpk1_s992_mpk1_mpk1_csa68"> <start x="992.0" y="1780.9943"/> <end x="1150.0" y="1694.0"/> </arc> <arc class="consumption" id="cons_cd48343a-9210-460b-acdd-6c8b204d73cb" source="mpk1_mpk1_s992_mpk1_mpk1_csa68" target="pr_1e0ff48d-bade-464c-9571-d1e91861621c_p1"> <start x="1242.5" y="1747.0"/> <end x="1217.9167" y="1761.5"/> </arc> <arc class="production" id="prod_4999da02-acc2-4315-bb2f-1cd2346af02e" source="pr_1e0ff48d-bade-464c-9571-d1e91861621c_p2" target="mpk1_mpk1_s991_mpk1_mpk1_csa3"> <start x="1217.9167" y="1791.5"/> <next x="1193.3334" y="1806.0"/> <end x="983.25" y="1760.0"/> </arc> <arc class="production" id="prod_df9c6d3a-4c66-48b2-b844-7e2f3a2cb75f" source="pr_1e0ff48d-bade-464c-9571-d1e91861621c_p2" target="mpk1_mpk1_s573_mpk1_mpk1_sa338"> <start x="1217.9167" y="1791.5"/> <next x="1193.3334" y="1806.0"/> <end x="1380.0" y="1927.0"/> </arc> <arc class="catalysis" id="modif_98369eae-43a0-4031-88df-ed9188126d31" source="mpk1_mpk1_s574_mpk1_mpk1_sa339" target="pr_1e0ff48d-bade-464c-9571-d1e91861621c"> <start x="1144.5" y="1974.5"/> <next x="1146.91" y="1772.7059"/> <end x="1214.0757" y="1773.2991"/> </arc> <arc class="consumption" id="cons_3fd81148-2ce2-4dde-8305-fc4f7c7be7ae" source="mpk1_mpk1_s613_mpk1_mpk1_sa344" target="pr_9e4d78c3-6935-43c9-a776-f711045251e4_p1"> <start x="429.0" y="2758.0"/> <end x="397.75" y="2758.5"/> </arc> <arc class="production" id="prod_1d45f453-d21c-448f-b136-3db41757f406" source="pr_9e4d78c3-6935-43c9-a776-f711045251e4_p2" target="mpk1_mpk1_s614_mpk1_mpk1_sa363"> <start x="367.75" y="2758.5"/> <end x="336.5" y="2759.0"/> </arc> <arc class="catalysis" id="modif_8046e574-4e69-4f36-b95f-a4288a4c7364" source="mpk1_mpk1_s578_mpk1_mpk1_sa343" target="pr_9e4d78c3-6935-43c9-a776-f711045251e4"> <start x="749.0" y="2700.5"/> <next x="382.9442" y="2701.5667"/> <end x="382.69595" y="2753.5002"/> </arc> <arc class="consumption" id="cons_4790d532-861d-4ad9-90d3-44f7c4412104" source="mpk1_mpk1_s613_mpk1_mpk1_sa344" target="pr_d6e8e238-c3af-493f-8c8e-5d7bde360033_p1"> <start x="465.0" y="2771.0"/> <end x="397.3846" y="2821.4614"/> </arc> <arc class="production" id="prod_75292d63-71dc-4fda-a158-2862627a5e70" source="pr_d6e8e238-c3af-493f-8c8e-5d7bde360033_p2" target="mpk1_mpk1_s585_mpk1_mpk1_sa349"> <start x="367.3846" y="2821.4614"/> <end x="299.76923" y="2871.923"/> </arc> <arc class="consumption" id="cons_48cb9faf-5b61-4b1e-b043-90d9129ddbd5" source="mpk1_mpk1_s585_mpk1_mpk1_sa349" target="pr_c335b9b9-fbc8-4dd1-bc8b-b66d46d88f00_p1"> <start x="299.76923" y="2897.923"/> <next x="299.76923" y="2951.9614"/> <end x="330.3846" y="2989.6323"/> </arc> <arc class="consumption" id="cons_2b8821c6-5b86-42a6-aafc-9966c57baa55" source="mpk1_mpk1_s577_mpk1_mpk1_sa342" target="pr_c335b9b9-fbc8-4dd1-bc8b-b66d46d88f00_p1"> <start x="239.75" y="2977.0"/> <next x="299.76923" y="2951.9614"/> <end x="330.3846" y="2989.6323"/> </arc> <arc class="production" id="prod_97b39579-c44d-49e0-bfd6-f3aad8495b0f" source="pr_c335b9b9-fbc8-4dd1-bc8b-b66d46d88f00_p2" target="mpk1_mpk1_s1019_mpk1_mpk1_csa70"> <start x="360.3846" y="2989.6323"/> <end x="387.0" y="3024.0"/> </arc> <arc class="consumption" id="cons_1e71fe08-5e16-469d-aa4c-89dd593dc7cf" source="mpk1_mpk1_s603_mpk1_mpk1_sa259" target="pr_b5bf03dd-5905-4737-bd1e-cf27ac64d193_p1"> <start x="2319.6667" y="2617.8335"/> <next x="2319.9685" y="2807.9111"/> <next x="1719.9998" y="2809.9998"/> <next x="1718.063" y="2800.182"/> <end x="1715.5315" y="2802.0908"/> </arc> <arc class="consumption" id="cons_e1b0c965-f0c8-4a5a-9f15-2ed938aab4dc" source="mpk1_mpk1_s578_mpk1_mpk1_sa343" target="pr_b5bf03dd-5905-4737-bd1e-cf27ac64d193_p1"> <start x="780.5" y="2714.0"/> <next x="779.96906" y="2816.2166"/> <next x="1719.9998" y="2809.9998"/> <next x="1718.063" y="2800.182"/> <end x="1715.5315" y="2802.0908"/> </arc> <arc class="production" id="prod_36af3926-08a7-409a-93ea-76084e1cc15c" source="pr_b5bf03dd-5905-4737-bd1e-cf27ac64d193_p2" target="mpk1_mpk1_s1016_mpk1_mpk1_csa71"> <start x="1715.5315" y="2772.0908"/> <next x="1712.9999" y="2773.9998"/> <end x="1714.5" y="2737.0"/> </arc> <arc class="consumption" id="addreact_30cb162b-30d7-49c9-a6a8-a85d87a97951" source="mpk1_mpk1_s604_mpk1_mpk1_sa326" target="pr_b5bf03dd-5905-4737-bd1e-cf27ac64d193_p1"> <start x="1822.5" y="2733.6665"/> <end x="1715.5315" y="2802.0908"/> </arc> <arc class="consumption" id="cons_e8056534-cd6c-42dc-b948-3ffcfa28b9e7" source="mpk1_mpk1_s578_mpk1_mpk1_sa343" target="pr_70a66450-3759-4c3b-85c2-cedb150681ee_p1"> <start x="812.0" y="2700.5"/> <next x="872.907" y="2702.2"/> <end x="873.7289" y="2427.4766"/> </arc> <arc class="production" id="prod_b28fa775-0dd4-4c85-8e5f-e212e0a7c90c" source="pr_70a66450-3759-4c3b-85c2-cedb150681ee_p2" target="mpk1_mpk1_s595_mpk1_mpk1_sa357"> <start x="873.7289" y="2397.4766"/> <next x="874.55084" y="2122.7534"/> <end x="1311.5" y="2128.0"/> </arc> <arc class="consumption" id="cons_55c8fd82-1b93-453b-8fe7-2624dc41f9aa" source="mpk1_mpk1_s595_mpk1_mpk1_sa357" target="pr_4da07250-289c-4d3d-becf-d4dc1b7efa6c_p1"> <start x="1343.0" y="2101.0"/> <end x="1343.0" y="2080.0"/> </arc> <arc class="production" id="prod_1d55e75c-b28c-4f0c-8c21-eb64396a9794" source="pr_4da07250-289c-4d3d-becf-d4dc1b7efa6c_p2" target="mpk1_mpk1_s599_mpk1_mpk1_sa361"> <start x="1343.0" y="2050.0"/> <end x="1343.0" y="2029.0"/> </arc> <arc class="catalysis" id="modif_c293e994-ce98-40d4-8a24-1fcbac73ba2f" source="mpk1_mpk1_s594_mpk1_mpk1_sa356" target="pr_4da07250-289c-4d3d-becf-d4dc1b7efa6c"> <start x="1400.5" y="2064.5"/> <end x="1348.0" y="2065.0"/> </arc> <arc class="consumption" id="cons_19e1f93f-a141-4949-90c0-56abdb4136d2" source="mpk1_mpk1_s575_mpk1_mpk1_sa340" target="pr_318d87ed-7bca-46c6-bfbb-c18cbe551ec9_p1"> <start x="1307.0" y="1945.5"/> <end x="1288.0" y="1905.5"/> </arc> <arc class="production" id="prod_ba7907b4-4262-4126-b2b6-420f29bf8c42" source="pr_318d87ed-7bca-46c6-bfbb-c18cbe551ec9_p2" target="mpk1_mpk1_s576_mpk1_mpk1_sa341"> <start x="1288.0" y="1875.5"/> <end x="1269.0" y="1835.5"/> </arc> <arc class="catalysis" id="modif_782ec1d2-a364-4533-aceb-a652209983cf" source="mpk1_mpk1_s573_mpk1_mpk1_sa338" target="pr_318d87ed-7bca-46c6-bfbb-c18cbe551ec9"> <start x="1347.0" y="1940.0"/> <end x="1294.3585" y="1893.5934"/> </arc> <arc class="consumption" id="cons_bb24500e-3597-4e1f-a248-2496c037adbb" source="mpk1_mpk1_s603_mpk1_mpk1_sa259" target="pr_a7c9ae95-6b38-4158-ae58-d101006bc6e3_p1"> <start x="2307.1667" y="2617.8335"/> <next x="2305.9133" y="2630.9043"/> <end x="1967.3282" y="2629.3445"/> </arc> <arc class="production" id="prod_fb135cdb-9aa9-4a90-a76d-f002006cc90b" source="pr_a7c9ae95-6b38-4158-ae58-d101006bc6e3_p2" target="mpk1_mpk1_s594_mpk1_mpk1_sa356"> <start x="1937.3282" y="2629.3445"/> <next x="1598.7432" y="2627.7847"/> <next x="1598.1199" y="2157.3376"/> <next x="1424.6996" y="2154.8723"/> <end x="1425.5" y="2077.0"/> </arc> <arc class="consumption" id="cons_24420b21-7dda-4737-afba-843726fad4d0" source="mpk1_mpk1_s596_mpk1_mpk1_sa360" target="pr_ef7c0fa4-a6c0-4559-87e9-2b1e0e9e9745_p1"> <start x="1219.5" y="2028.0"/> <end x="1214.25" y="2038.75"/> </arc> <arc class="production" id="prod_2e6ef8d6-95e8-445f-8e71-68698caf75bb" source="pr_ef7c0fa4-a6c0-4559-87e9-2b1e0e9e9745_p2" target="mpk1_mpk1_s598_mpk1_mpk1_sa358"> <start x="1214.25" y="2068.75"/> <end x="1209.0" y="2079.5"/> </arc> <arc class="catalysis" id="modif_57a22b73-4bbc-41e9-b8f2-38a37464cf60" source="mpk1_mpk1_s595_mpk1_mpk1_sa357" target="pr_ef7c0fa4-a6c0-4559-87e9-2b1e0e9e9745"> <start x="1311.5" y="2101.0"/> <end x="1219.1492" y="2054.7488"/> </arc> <arc class="consumption" id="cons_cccce36a-bb15-40c4-8f02-2f2fcd5cc7c0" source="mpk1_mpk1_s9_mpk1_mpk1_sa369" target="pr_83b04f62-8cd6-47a6-b313-6a00f206ab9a_p1"> <start x="2360.4963" y="1340.0"/> <next x="2360.9963" y="1435.5"/> <end x="2378.4963" y="1434.4344"/> </arc> <arc class="consumption" id="cons_c7c8569a-a8ef-4982-ad22-5dcb35d4e813" source="mpk1_mpk1_s10_mpk1_mpk1_sa370" target="pr_83b04f62-8cd6-47a6-b313-6a00f206ab9a_p1"> <start x="2369.4963" y="1823.0"/> <next x="2360.9963" y="1435.5"/> <end x="2378.4963" y="1434.4344"/> </arc> <arc class="production" id="prod_930e30fc-5148-4f63-9638-6b54c69bd41f" source="pr_83b04f62-8cd6-47a6-b313-6a00f206ab9a_p2" target="mpk1_mpk1_s16_mpk1_mpk1_csa73"> <start x="2408.4963" y="1434.4344"/> <end x="2421.9963" y="1433.5"/> </arc> <arc class="consumption" id="cons_a1eefe54-cd07-4746-a6e0-3b2116a4eba8" source="mpk1_mpk1_s8_mpk1_mpk1_sa368" target="pr_fcac7d9a-7ae7-4508-9b4f-fd58527b2964_p1"> <start x="2604.9963" y="1871.0"/> <next x="2407.1924" y="1769.7379"/> <next x="2392.4963" y="1495.0"/> <end x="2424.1504" y="1513.25"/> </arc> <arc class="consumption" id="cons_e54e6544-276c-47b7-bb88-55bf831aed1c" source="mpk1_mpk1_s16_mpk1_mpk1_csa73" target="pr_fcac7d9a-7ae7-4508-9b4f-fd58527b2964_p1"> <start x="2421.9963" y="1475.0"/> <next x="2392.4963" y="1495.0"/> <end x="2424.1504" y="1513.25"/> </arc> <arc class="production" id="prod_11f7a6fd-e896-456b-a842-f0cbf573aa60" source="pr_fcac7d9a-7ae7-4508-9b4f-fd58527b2964_p2" target="mpk1_mpk1_s15_mpk1_mpk1_csa72"> <start x="2424.1504" y="1543.25"/> <end x="2451.9963" y="1557.5"/> </arc> <arc class="consumption" id="cons_8ca5727b-5a0b-47a1-b4ae-9755f19a3d6f" source="mpk1_mpk1_s13_mpk1_mpk1_sa372" target="pr_64a89605-a916-41d0-9bc0-a73e8f32382c_p1"> <start x="2492.9963" y="1856.5"/> <next x="2424.2773" y="1856.3392"/> <next x="2413.9963" y="1645.0001"/> <end x="2431.4346" y="1654.25"/> </arc> <arc class="consumption" id="cons_0c5b99b3-3b83-4dee-906a-73277295a742" source="mpk1_mpk1_s15_mpk1_mpk1_csa72" target="pr_64a89605-a916-41d0-9bc0-a73e8f32382c_p1"> <start x="2451.9963" y="1614.0"/> <next x="2413.9963" y="1645.0001"/> <end x="2431.4346" y="1654.25"/> </arc> <arc class="production" id="prod_205ed231-bead-4af1-905a-c42bed4ae0d8" source="pr_64a89605-a916-41d0-9bc0-a73e8f32382c_p2" target="mpk1_mpk1_s14_mpk1_mpk1_csa74"> <start x="2431.4346" y="1684.25"/> <end x="2445.9963" y="1689.5"/> </arc> <arc class="consumption" id="cons_b5bb26d2-e43a-4091-bfe4-4ab5e870b900" source="mpk1_mpk1_s8_mpk1_mpk1_sa368" target="pr_52ea4924-bb13-4c4b-8dfc-01ec8a3d7f42_p1"> <start x="2617.4963" y="1871.0"/> <next x="2683.3152" y="1728.217"/> <next x="2674.9963" y="1550.0"/> <end x="2687.4963" y="1549.4607"/> </arc> <arc class="consumption" id="cons_e49c1401-0c98-4316-a533-6f3887031073" source="mpk1_mpk1_s22_mpk1_mpk1_sa374" target="pr_52ea4924-bb13-4c4b-8dfc-01ec8a3d7f42_p1"> <start x="2671.9963" y="1341.0"/> <next x="2674.9963" y="1550.0"/> <end x="2687.4963" y="1549.4607"/> </arc> <arc class="production" id="prod_98ce675c-55cd-4868-aa9d-43cedd5dab9b" source="pr_52ea4924-bb13-4c4b-8dfc-01ec8a3d7f42_p2" target="mpk1_mpk1_s23_mpk1_mpk1_csa75"> <start x="2717.4963" y="1549.4607"/> <end x="2725.9963" y="1549.0"/> </arc> <arc class="consumption" id="cons_6eda36c3-461e-4fa3-99cb-1581686ec5b5" source="mpk1_mpk1_s8_mpk1_mpk1_sa368" target="pr_5690674e-cd92-4e4f-a6f7-d53244b02e2d_p1"> <start x="2642.4963" y="1883.5"/> <next x="2885.529" y="1652.8514"/> <next x="2882.9963" y="1445.0"/> <end x="2898.4963" y="1473.3596"/> </arc> <arc class="consumption" id="cons_2861758d-3d60-4f7b-a061-05009edf9abf" source="mpk1_mpk1_s21_mpk1_mpk1_sa373" target="pr_5690674e-cd92-4e4f-a6f7-d53244b02e2d_p1"> <start x="2900.9963" y="1389.0"/> <next x="2882.9963" y="1445.0"/> <end x="2898.4963" y="1473.3596"/> </arc> <arc class="production" id="prod_b96ba4b2-86fb-462f-bd33-fc54816a76b6" source="pr_5690674e-cd92-4e4f-a6f7-d53244b02e2d_p2" target="mpk1_mpk1_s26_mpk1_mpk1_csa81"> <start x="2928.4963" y="1473.3596"/> <end x="2939.9963" y="1498.0"/> </arc> <arc class="consumption" id="cons_d84e02c3-ddf5-4099-8f61-f07d0b6a8d83" source="mpk1_mpk1_s30_mpk1_mpk1_sa376" target="pr_63a11d46-6d0c-4588-933b-6aa85b7c76f1_p1"> <start x="2987.2463" y="1852.0"/> <next x="2992.9963" y="1420.0"/> <end x="3019.4963" y="1450.2057"/> </arc> <arc class="consumption" id="cons_2dc7d028-921b-4816-bffc-280b304965c2" source="mpk1_mpk1_s31_mpk1_mpk1_sa377" target="pr_63a11d46-6d0c-4588-933b-6aa85b7c76f1_p1"> <start x="3062.9963" y="1338.0"/> <next x="2992.9963" y="1420.0"/> <end x="3019.4963" y="1450.2057"/> </arc> <arc class="production" id="prod_caafd224-0a56-47ee-a389-d689b5258498" source="pr_63a11d46-6d0c-4588-933b-6aa85b7c76f1_p2" target="mpk1_mpk1_s32_mpk1_mpk1_csa77"> <start x="3049.4963" y="1450.2057"/> <end x="3071.9963" y="1477.5"/> </arc> <arc class="consumption" id="cons_5019bc12-199d-45f1-877b-fe409f6299ce" source="mpk1_mpk1_s29_mpk1_mpk1_sa375" target="pr_4c7645c2-0a23-4ce4-9647-a36e606b9ab6_p1"> <start x="3025.4963" y="1851.0"/> <next x="3016.9963" y="1594.0"/> <end x="3029.9963" y="1594.0"/> </arc> <arc class="consumption" id="cons_84c725c8-f1ce-4405-b60b-54658fac6af6" source="mpk1_mpk1_s32_mpk1_mpk1_csa77" target="pr_4c7645c2-0a23-4ce4-9647-a36e606b9ab6_p1"> <start x="3071.9963" y="1518.0"/> <next x="3016.9963" y="1594.0"/> <end x="3029.9963" y="1594.0"/> </arc> <arc class="production" id="prod_d0dd7004-b89b-457d-9bd1-2a80d023854f" source="pr_4c7645c2-0a23-4ce4-9647-a36e606b9ab6_p2" target="mpk1_mpk1_s999_mpk1_mpk1_csa79"> <start x="3059.9963" y="1594.0"/> <end x="3068.9963" y="1594.0"/> </arc> <arc class="consumption" id="cons_6eba53bd-2c85-46dc-af1d-6698f8919384" source="mpk1_mpk1_s11_mpk1_mpk1_sa371" target="pr_0499546c-9149-44fd-91d9-8c6be977f331_p1"> <start x="3252.4963" y="1840.0"/> <next x="3249.4963" y="1595.0"/> <end x="3237.0005" y="1613.5"/> </arc> <arc class="consumption" id="cons_239532a6-67a6-4712-9d2b-98c8c6a2374a" source="mpk1_mpk1_s999_mpk1_mpk1_csa79" target="pr_0499546c-9149-44fd-91d9-8c6be977f331_p1"> <start x="3213.9963" y="1594.0"/> <next x="3249.4963" y="1595.0"/> <end x="3237.0005" y="1613.5"/> </arc> <arc class="production" id="prod_7e8d3af2-306f-44b7-8a60-12af5a651f79" source="pr_0499546c-9149-44fd-91d9-8c6be977f331_p2" target="mpk1_mpk1_s705_mpk1_mpk1_csa78"> <start x="3237.0005" y="1643.5"/> <end x="3225.9963" y="1658.0"/> </arc> <arc class="consumption" id="cons_2ce6a751-dee4-49f6-8f29-050630bef740" source="mpk1_mpk1_s49_mpk1_mpk1_csa80" target="pr_4bf3b409-432b-46c2-b5fa-ea927d0c33e2_p1"> <start x="3484.9963" y="1378.0"/> <next x="3480.4963" y="1659.5"/> <end x="3467.7463" y="1659.5"/> </arc> <arc class="consumption" id="cons_3b437803-d5bc-4826-9580-1b44a6ceb69f" source="mpk1_mpk1_s666_mpk1_mpk1_sa379" target="pr_4bf3b409-432b-46c2-b5fa-ea927d0c33e2_p1"> <start x="3480.9963" y="1845.0"/> <next x="3480.4963" y="1659.5"/> <end x="3467.7463" y="1659.5"/> </arc> <arc class="production" id="prod_e912cfbc-05ff-495e-a246-3ac72c505075" source="pr_4bf3b409-432b-46c2-b5fa-ea927d0c33e2_p2" target="mpk1_mpk1_s1000_mpk1_mpk1_csa76"> <start x="3437.7463" y="1659.5"/> <end x="3428.9963" y="1659.5"/> </arc> <arc class="consumption" id="cons_da47c936-6995-4678-be7e-b1fa7f43ead4" source="mpk1_mpk1_s45_mpk1_mpk1_sa378" target="pr_b43038b1-66b1-4ffa-b225-c5ccf641121f_p1"> <start x="3642.7463" y="1902.0"/> <next x="3854.9963" y="1799.0"/> <end x="3853.1978" y="2026.5752"/> </arc> <arc class="consumption" id="cons_d3c1c941-db26-4e62-81e3-40ee77945147" source="mpk1_mpk1_s1000_mpk1_mpk1_csa76" target="pr_b43038b1-66b1-4ffa-b225-c5ccf641121f_p1"> <start x="3428.9963" y="1700.0"/> <next x="3429.5325" y="1802.2985"/> <next x="3854.9963" y="1799.0"/> <end x="3853.1978" y="2026.5752"/> </arc> <arc class="production" id="prod_11b0aa06-9f2e-44c0-8291-5f933515be68" source="pr_b43038b1-66b1-4ffa-b225-c5ccf641121f_p2" target="mpk1_mpk1_s1036_mpk1_mpk1_csa82"> <start x="3853.1978" y="2056.5752"/> <next x="3851.4287" y="2280.1504"/> <end x="3825.9963" y="2280.5"/> </arc> <arc class="consumption" id="cons_742c2ed5-4e82-43f0-b4d5-c33bea42ec4b" source="mpk1_mpk1_s45_mpk1_mpk1_sa378" target="pr_5f54347b-4566-4d8e-b200-8326294752ec_p1"> <start x="3623.4963" y="1902.0"/> <next x="3624.4963" y="1759.0"/> <next x="3884.4978" y="1761.4487"/> <end x="3885.247" y="1914.7244"/> </arc> <arc class="consumption" id="cons_e8347962-8cdf-460c-b906-79f8e8ef4278" source="mpk1_mpk1_s705_mpk1_mpk1_csa78" target="pr_5f54347b-4566-4d8e-b200-8326294752ec_p1"> <start x="3130.9963" y="1743.0"/> <next x="3130.7878" y="1758.8793"/> <next x="3624.4963" y="1759.0"/> <next x="3884.4978" y="1761.4487"/> <end x="3885.247" y="1914.7244"/> </arc> <arc class="production" id="prod_b5bd6f82-e8cb-43f2-898e-74913ac4f2ce" source="pr_5f54347b-4566-4d8e-b200-8326294752ec_p2" target="mpk1_mpk1_s1038_mpk1_mpk1_csa83"> <start x="3885.247" y="1944.7244"/> <end x="3885.9963" y="2098.0"/> </arc> <arc class="consumption" id="cons_1a0f9d01-13b2-4871-8a79-81b794444b73" source="mpk1_mpk1_s14_mpk1_mpk1_csa74" target="pr_f0961a52-9c68-499f-b641-f7738a5307f0_p1"> <start x="2607.9963" y="1732.0"/> <next x="2607.6616" y="1819.2473"/> <next x="3704.8523" y="1821.1644"/> <next x="3703.996" y="1915.0"/> <end x="3705.3188" y="1936.5"/> </arc> <arc class="consumption" id="cons_d796f21d-2f35-4ae0-9a4d-b4671cf96937" source="mpk1_mpk1_s45_mpk1_mpk1_sa378" target="pr_f0961a52-9c68-499f-b641-f7738a5307f0_p1"> <start x="3661.9963" y="1914.5"/> <next x="3703.996" y="1915.0"/> <end x="3705.3188" y="1936.5"/> </arc> <arc class="production" id="prod_84ef6e27-ee79-48d9-9a18-7a1576bbb63c" source="pr_f0961a52-9c68-499f-b641-f7738a5307f0_p2" target="mpk1_mpk1_s1047_mpk1_mpk1_csa93"> <start x="3705.3188" y="1966.5"/> <end x="3706.4963" y="1984.0"/> </arc> <arc class="consumption" id="cons_0941b861-724e-4efa-98b6-94cb114769ea" source="mpk1_mpk1_s23_mpk1_mpk1_csa75" target="pr_1b8bb2a1-1d24-425f-8e3b-3e5fe1d0ee2b_p1"> <start x="2791.9963" y="1589.0"/> <next x="2796.7163" y="1797.2583"/> <next x="3605.9963" y="1796.0"/> <next x="3590.225" y="1890.2683"/> <next x="3556.0305" y="1899.5902"/> <end x="3554.4668" y="1981.6699"/> </arc> <arc class="consumption" id="cons_f556cb15-0b75-4093-8959-e4c5cf3bd185" source="mpk1_mpk1_s45_mpk1_mpk1_sa378" target="pr_1b8bb2a1-1d24-425f-8e3b-3e5fe1d0ee2b_p1"> <start x="3604.2463" y="1902.0"/> <next x="3605.9963" y="1796.0"/> <next x="3590.225" y="1890.2683"/> <next x="3556.0305" y="1899.5902"/> <end x="3554.4668" y="1981.6699"/> </arc> <arc class="production" id="prod_59fda571-af60-40ab-b1f4-7393e2d25420" source="pr_1b8bb2a1-1d24-425f-8e3b-3e5fe1d0ee2b_p2" target="mpk1_mpk1_s1044_mpk1_mpk1_csa85"> <start x="3554.4668" y="2011.6699"/> <next x="3552.9033" y="2093.7495"/> <end x="3624.9963" y="2096.0"/> </arc> <arc class="consumption" id="cons_4958ab51-93a7-4ab1-9550-3c9a2e65c46c" source="mpk1_mpk1_s991_mpk1_mpk1_csa3" target="pr_2ddd57ba-551f-4f59-a912-d3545e587c0f_p1"> <start x="1019.0" y="1734.25"/> <next x="1102.7268" y="1733.038"/> <next x="1097.9014" y="1293.0421"/> <next x="3273.199" y="1290.2991"/> <next x="3276.4001" y="1886.4615"/> <next x="3418.2979" y="1885.1539"/> <end x="3418.849" y="1984.8076"/> </arc> <arc class="consumption" id="cons_c4a41afb-806a-4b3e-b756-01f8476ace57" source="mpk1_mpk1_s76_mpk1_mpk1_sa380" target="pr_2ddd57ba-551f-4f59-a912-d3545e587c0f_p1"> <start x="3256.9963" y="1884.25"/> <next x="3276.4001" y="1886.4615"/> <next x="3418.2979" y="1885.1539"/> <end x="3418.849" y="1984.8076"/> </arc> <arc class="production" id="prod_f31bf9c6-a46b-441b-bbbb-7efb3523b2f0" source="pr_2ddd57ba-551f-4f59-a912-d3545e587c0f_p2" target="mpk1_mpk1_s1041_mpk1_mpk1_csa89"> <start x="3418.849" y="2014.8076"/> <end x="3419.4004" y="2114.4614"/> </arc> <arc class="consumption" id="cons_4fabbb82-e06f-43f8-945a-2c71abdbe52f" source="mpk1_mpk1_s76_mpk1_mpk1_sa380" target="pr_55e4511c-c86e-490a-831c-6f11fff38ee3_p1"> <start x="3218.4963" y="1903.0"/> <next x="3217.1665" y="1944.5033"/> <next x="3114.9963" y="1946.0"/> <end x="3117.4277" y="2017.0"/> </arc> <arc class="consumption" id="cons_a5a17941-4185-4527-80ae-7d485ccfa2df" source="mpk1_mpk1_s14_mpk1_mpk1_csa74" target="pr_55e4511c-c86e-490a-831c-6f11fff38ee3_p1"> <start x="2553.9963" y="1732.0"/> <next x="2555.8313" y="1770.057"/> <next x="2928.2502" y="1779.1573"/> <next x="2930.1304" y="1945.3026"/> <next x="3114.9963" y="1946.0"/> <end x="3117.4277" y="2017.0"/> </arc> <arc class="production" id="prod_584df2d3-6265-4a29-aafb-396d6d077a68" source="pr_55e4511c-c86e-490a-831c-6f11fff38ee3_p2" target="mpk1_mpk1_s1046_mpk1_mpk1_csa90"> <start x="3117.4277" y="2047.0"/> <end x="3119.7463" y="2114.0"/> </arc> <arc class="consumption" id="cons_9cbe8241-8351-4f68-9127-3e8e5547e393" source="mpk1_mpk1_s76_mpk1_mpk1_sa380" target="pr_884f5261-e651-44a8-9a38-0d3f9a65f92a_p1"> <start x="3179.9963" y="1884.25"/> <next x="2855.9963" y="1884.5"/> <next x="2816.3418" y="1883.567"/> <end x="2818.1116" y="2037.3118"/> </arc> <arc class="consumption" id="cons_d252ec8d-7172-4909-89d2-5b49c3164984" source="mpk1_mpk1_s23_mpk1_mpk1_csa75" target="pr_884f5261-e651-44a8-9a38-0d3f9a65f92a_p1"> <start x="2857.9963" y="1589.0"/> <next x="2855.9963" y="1884.5"/> <next x="2816.3418" y="1883.567"/> <end x="2818.1116" y="2037.3118"/> </arc> <arc class="production" id="prod_bef5e6ff-da39-45f0-b180-4c87b2ddfed0" source="pr_884f5261-e651-44a8-9a38-0d3f9a65f92a_p2" target="mpk1_mpk1_s1042_mpk1_mpk1_csa97"> <start x="2818.1116" y="2067.3118"/> <next x="2819.8813" y="2221.0566"/> <next x="3257.9617" y="2218.1433"/> <end x="3257.9963" y="2240.0"/> </arc> <arc class="consumption" id="cons_8ea57934-0338-4ae8-a3c4-3d99816f0f94" source="mpk1_mpk1_s991_mpk1_mpk1_csa3" target="pr_3c64d572-7b3b-44b8-ad68-7168e2b5bd89_p1"> <start x="1019.0" y="1657.0"/> <next x="1098.9565" y="1654.8962"/> <next x="1097.5789" y="1294.2528"/> <next x="3268.4614" y="1295.6858"/> <next x="3271.4963" y="1904.7812"/> <end x="3273.101" y="1920.3906"/> </arc> <arc class="consumption" id="cons_391bae87-a105-49ad-9f33-ea0f37570f5f" source="mpk1_mpk1_s669_mpk1_mpk1_sa383" target="pr_3c64d572-7b3b-44b8-ad68-7168e2b5bd89_p1"> <start x="3376.4963" y="1875.0"/> <next x="3382.687" y="1905.0804"/> <next x="3271.4963" y="1904.7812"/> <end x="3273.101" y="1920.3906"/> </arc> <arc class="production" id="prod_31b062d1-c5c4-4eef-881e-a8b475ddf944" source="pr_3c64d572-7b3b-44b8-ad68-7168e2b5bd89_p2" target="mpk1_mpk1_s1040_mpk1_mpk1_csa100"> <start x="3273.101" y="1950.3906"/> <end x="3274.4963" y="1962.0"/> </arc> <arc class="consumption" id="cons_1836d9e4-ef68-48de-b094-c310f2f9b256" source="mpk1_mpk1_s669_mpk1_mpk1_sa383" target="pr_d75ab7bf-6593-4392-8cac-526300a509af_p1"> <start x="3395.7463" y="1850.0"/> <next x="3404.54" y="1809.1719"/> <next x="3146.9963" y="1809.0"/> <end x="3148.9077" y="1934.327"/> </arc> <arc class="consumption" id="cons_ce81a0b4-1914-4e0b-ba01-9effe6622de0" source="mpk1_mpk1_s14_mpk1_mpk1_csa74" target="pr_d75ab7bf-6593-4392-8cac-526300a509af_p1"> <start x="2661.9963" y="1732.0"/> <next x="2667.4153" y="1812.4694"/> <next x="3146.9963" y="1809.0"/> <end x="3148.9077" y="1934.327"/> </arc> <arc class="production" id="prod_d06dfa6e-5a72-416b-8de5-cad4918a014f" source="pr_d75ab7bf-6593-4392-8cac-526300a509af_p2" target="mpk1_mpk1_s1049_mpk1_mpk1_csa92"> <start x="3148.9077" y="1964.327"/> <next x="3150.765" y="2085.654"/> <next x="3040.2832" y="2086.7542"/> <next x="3041.536" y="2211.0042"/> <end x="3063.9963" y="2243.0"/> </arc> <arc class="consumption" id="cons_631c3146-0ace-4f7d-a5da-bf97db528dc7" source="mpk1_mpk1_s669_mpk1_mpk1_sa383" target="pr_cadc6ebd-f4bd-47cc-8042-7f0db13f9127_p1"> <start x="3357.2463" y="1850.0"/> <next x="3359.0383" y="1830.8164"/> <next x="2836.9963" y="1830.0"/> <end x="2835.9824" y="1962.0"/> </arc> <arc class="consumption" id="cons_c26eb9d2-06cd-4479-928b-56f2d95fb5bf" source="mpk1_mpk1_s23_mpk1_mpk1_csa75" target="pr_cadc6ebd-f4bd-47cc-8042-7f0db13f9127_p1"> <start x="2824.9963" y="1589.0"/> <next x="2836.9963" y="1830.0"/> <end x="2835.9824" y="1962.0"/> </arc> <arc class="production" id="prod_c6fdc785-d8e0-440b-865b-42d8849d21ed" source="pr_cadc6ebd-f4bd-47cc-8042-7f0db13f9127_p2" target="mpk1_mpk1_s1045_mpk1_mpk1_csa94"> <start x="2835.9824" y="1992.0"/> <end x="2834.9963" y="2120.0"/> </arc> <arc class="consumption" id="cons_3d3a4191-092b-424f-a8fb-0f1de7b79ad3" source="mpk1_mpk1_s670_mpk1_mpk1_sa384" target="pr_2b48d41c-0a3b-42c1-8a48-e59dec0b5c15_p1"> <start x="4090.0" y="2577.5"/> <next x="4090.0" y="2520.0"/> <next x="4210.0" y="2520.0"/> <next x="4210.0" y="2220.0"/> <next x="4150.0" y="2220.0"/> <end x="4073.4146" y="2220.0256"/> </arc> <arc class="consumption" id="cons_3e13a1dc-ccdf-4dbb-97ed-8a02fc240e6d" source="mpk1_mpk1_s671_mpk1_mpk1_sa385" target="pr_2b48d41c-0a3b-42c1-8a48-e59dec0b5c15_p1"> <start x="4141.0" y="2257.5"/> <next x="4150.0" y="2220.0"/> <end x="4073.4146" y="2220.0256"/> </arc> <arc class="production" id="prod_17abae8d-ed37-4753-a564-1b200cb3f983" source="pr_2b48d41c-0a3b-42c1-8a48-e59dec0b5c15_p2" target="mpk1_mpk1_s1035_mpk1_mpk1_csa95"> <start x="4043.4146" y="2220.0256"/> <next x="3970.829" y="2220.05"/> <end x="3935.4963" y="2233.0"/> </arc> <arc class="consumption" id="cons_4dc537a1-952f-4596-9faa-f448c373a2a1" source="mpk1_mpk1_s1037_mpk1_mpk1_csa96" target="pr_329a3f0d-7846-47a3-82a9-5a1d75ba3ce0_p1"> <start x="3488.4963" y="1977.0"/> <next x="3489.0515" y="1958.5431"/> <next x="4047.1536" y="1958.0089"/> <end x="4047.525" y="1958.1138"/> </arc> <arc class="production" id="prod_b97e523d-a3f9-4bb9-9b1a-fa1e5f85b6be" source="pr_329a3f0d-7846-47a3-82a9-5a1d75ba3ce0_p2" target="mpk1_mpk1_s672_mpk1_mpk1_sa386"> <start x="4047.525" y="1928.1138"/> <next x="4047.8962" y="1928.2188"/> <end x="4047.0" y="1852.5"/> </arc> <arc class="production" id="prod_ed6c560e-d63f-47d9-9356-d123bf3dcff2" source="pr_329a3f0d-7846-47a3-82a9-5a1d75ba3ce0_p2" target="mpk1_mpk1_s673_mpk1_mpk1_sa387"> <start x="4047.525" y="1928.1138"/> <next x="4047.8962" y="1928.2188"/> <end x="4112.996" y="1923.5"/> </arc> <arc class="catalysis" id="modif_b9c8ae94-8ea6-4f9a-b289-a662d17a909b" source="mpk1_mpk1_s600_mpk1_mpk1_sa388" target="pr_329a3f0d-7846-47a3-82a9-5a1d75ba3ce0"> <start x="3133.9963" y="1923.0"/> <end x="4042.4019" y="1947.9875"/> </arc> <arc class="consumption" id="cons_93e91371-d5e9-49d4-b298-8fe19fa65630" source="mpk1_mpk1_s23_mpk1_mpk1_csa75" target="pr_4eceb807-e373-4d03-a568-532c3ccd33aa_p1"> <start x="2758.9963" y="1589.0"/> <end x="2758.3794" y="1660.7399"/> </arc> <arc class="production" id="prod_6a4cfd27-bec2-4c66-936d-f67b12cedc90" source="pr_4eceb807-e373-4d03-a568-532c3ccd33aa_p2" target="mpk1_mpk1_s600_mpk1_mpk1_sa388"> <start x="2758.3794" y="1690.7399"/> <next x="2757.7627" y="1762.4797"/> <next x="3080.4373" y="1763.0233"/> <end x="3085.6025" y="1911.4515"/> </arc> <arc class="consumption" id="cons_d1347217-731f-4f9a-9993-079949db5fe0" source="mpk1_mpk1_s15_mpk1_mpk1_csa72" target="pr_45c30aaa-bf5e-4711-a1e2-122bd3fbef14_p1"> <start x="2631.9963" y="1614.0"/> <end x="2752.924" y="1613.8262"/> </arc> <arc class="production" id="prod_6522d8a5-0e5d-4bd9-8996-9d15c4a8e57e" source="pr_45c30aaa-bf5e-4711-a1e2-122bd3fbef14_p2" target="mpk1_mpk1_s600_mpk1_mpk1_sa388"> <start x="2782.924" y="1613.8262"/> <next x="2903.8518" y="1613.6525"/> <next x="2905.843" y="1910.915"/> <end x="3074.2476" y="1914.1611"/> </arc> <arc class="consumption" id="cons_f68fe3d4-4fd4-4409-9fd9-c7f697baa950" source="mpk1_mpk1_s14_mpk1_mpk1_csa74" target="pr_f3a0ba02-b118-487c-ac31-46a5226b1813_p1"> <start x="2661.9963" y="1710.75"/> <next x="2674.877" y="1825.5892"/> <next x="3973.9192" y="1823.2618"/> <next x="3972.9963" y="1840.0"/> <end x="3972.3528" y="1894.5"/> </arc> <arc class="consumption" id="cons_0691bcf2-680f-4a98-935a-ddf41f6553b5" source="mpk1_mpk1_s672_mpk1_mpk1_sa386" target="pr_f3a0ba02-b118-487c-ac31-46a5226b1813_p1"> <start x="4008.5" y="1840.0"/> <next x="3972.9963" y="1840.0"/> <end x="3972.3528" y="1894.5"/> </arc> <arc class="production" id="prod_143c238c-8184-4ed3-9872-e8a433214906" source="pr_f3a0ba02-b118-487c-ac31-46a5226b1813_p2" target="mpk1_mpk1_s1048_mpk1_mpk1_csa91"> <start x="3972.3528" y="1924.5"/> <end x="3971.7463" y="1975.0"/> </arc> <arc class="consumption" id="cons_a69b1a6a-4e3a-48d9-bec8-3fa6c00daf1f" source="mpk1_mpk1_s23_mpk1_mpk1_csa75" target="pr_bd6ede8e-3c7f-4c4b-a03e-bbd6ca182d36_p1"> <start x="2791.9963" y="1509.0"/> <next x="2793.5815" y="1286.1412"/> <next x="3594.4702" y="1286.9363"/> <next x="3594.4248" y="1764.559"/> <next x="4047.4963" y="1774.0"/> <next x="4187.238" y="1774.5267"/> <end x="4187.4414" y="1977.3313"/> </arc> <arc class="consumption" id="cons_cc834823-972d-49c5-aeff-242079e9d6a8" source="mpk1_mpk1_s672_mpk1_mpk1_sa386" target="pr_bd6ede8e-3c7f-4c4b-a03e-bbd6ca182d36_p1"> <start x="4047.0" y="1827.5"/> <next x="4047.4963" y="1774.0"/> <next x="4187.238" y="1774.5267"/> <end x="4187.4414" y="1977.3313"/> </arc> <arc class="production" id="prod_e2555798-cb33-4e11-a514-a30cdc678746" source="pr_bd6ede8e-3c7f-4c4b-a03e-bbd6ca182d36_p2" target="mpk1_mpk1_s1043_mpk1_mpk1_csa98"> <start x="4187.4414" y="2007.3313"/> <next x="4187.6455" y="2210.136"/> <next x="3612.3364" y="2209.759"/> <end x="3577.9963" y="2242.0"/> </arc> <arc class="consumption" id="cons_e3188267-1094-4c49-b514-d107730f87e5" source="mpk1_mpk1_s989_mpk1_mpk1_csa6" target="pr_316438a2-094f-4b77-9692-b73515462cf6_p1"> <start x="900.0" y="1465.0"/> <next x="1050.4965" y="1475.1875"/> <end x="1096.7465" y="1472.6355"/> </arc> <arc class="consumption" id="cons_8bb25496-1af3-4fec-b4a7-dc51bd338b65" source="mpk1_mpk1_s618_mpk1_mpk1_sa389" target="pr_316438a2-094f-4b77-9692-b73515462cf6_p1"> <start x="1035.0" y="1577.5"/> <next x="1050.4965" y="1475.1875"/> <end x="1096.7465" y="1472.6355"/> </arc> <arc class="production" id="prod_ee1a6eff-1cf3-4e08-92c1-97f4e634b29b" source="pr_316438a2-094f-4b77-9692-b73515462cf6_p2" target="mpk1_mpk1_s990_mpk1_mpk1_csa99"> <start x="1126.7465" y="1472.6355"/> <end x="1168.9965" y="1470.25"/> </arc> <arc class="consumption" id="cons_089fd6b2-92c9-42ed-9b90-b71334241184" source="mpk1_mpk1_s990_mpk1_mpk1_csa99" target="pr_c829e85b-3dac-4679-a869-b01f48b513ae_p1"> <start x="1168.9965" y="1418.75"/> <end x="1095.3715" y="1414.4716"/> </arc> <arc class="production" id="prod_619eeb74-1cdb-4d75-83d9-d8c7a98eb41c" source="pr_c829e85b-3dac-4679-a869-b01f48b513ae_p2" target="mpk1_mpk1_s618_mpk1_mpk1_sa389"> <start x="1065.3715" y="1414.4716"/> <next x="991.74646" y="1410.1931"/> <end x="1005.0" y="1577.5"/> </arc> <arc class="production" id="prod_6bbb4666-3381-4050-9f22-917f53005bb9" source="pr_c829e85b-3dac-4679-a869-b01f48b513ae_p2" target="mpk1_mpk1_s989_mpk1_mpk1_csa6"> <start x="1065.3715" y="1414.4716"/> <next x="991.74646" y="1410.1931"/> <end x="900.0" y="1413.0"/> </arc> <arc class="consumption" id="cons_88ab194a-d5e5-497b-8a3c-296f25c2f7f1" source="mpk1_mpk1_s990_mpk1_mpk1_csa99" target="pr_66eca9a6-1d17-431a-9d45-a2931e9f9528_p1"> <start x="1244.9965" y="1393.0"/> <next x="1249.5809" y="1286.0183"/> <next x="2860.125" y="1283.2391"/> <next x="2868.996" y="1853.0"/> <end x="2893.3667" y="1894.0"/> </arc> <arc class="consumption" id="cons_117561dd-70f9-41ef-8323-f8d1b4f8c6f4" source="mpk1_mpk1_s626_mpk1_mpk1_sa390" target="pr_66eca9a6-1d17-431a-9d45-a2931e9f9528_p1"> <start x="2770.9963" y="1850.5"/> <next x="2868.996" y="1853.0"/> <end x="2893.3667" y="1894.0"/> </arc> <arc class="production" id="prod_55d5e95b-358f-4b33-b321-a8071198b785" source="pr_66eca9a6-1d17-431a-9d45-a2931e9f9528_p2" target="mpk1_mpk1_s1039_mpk1_mpk1_csa84"> <start x="2893.3667" y="1924.0"/> <end x="2915.9963" y="1961.0"/> </arc> <arc class="consumption" id="cons_5289902a-50a1-4651-8a4d-9ab0d26803af" source="mpk1_mpk1_s642_mpk1_mpk1_sa393" target="pr_65758942-a880-41bf-953a-49707313d6a0_p1"> <start x="2715.9963" y="2491.5"/> <next x="2775.7925" y="2491.6536"/> <end x="2837.0308" y="2491.8496"/> </arc> <arc class="production" id="prod_6b126848-35a0-4594-bd6f-bb6f7a793dfe" source="pr_65758942-a880-41bf-953a-49707313d6a0_p2" target="mpk1_mpk1_s663_mpk1_mpk1_sa394"> <start x="2867.0308" y="2491.8496"/> <end x="2928.269" y="2492.0454"/> </arc> <arc class="catalysis" id="modif_3ae52ce9-22c3-4a90-8c43-45daa4dc8541" source="mpk1_mpk1_s1041_mpk1_mpk1_csa89" target="pr_65758942-a880-41bf-953a-49707313d6a0"> <start x="3368.1504" y="2217.4614"/> <next x="3367.003" y="2362.0093"/> <next x="2876.2153" y="2366.143"/> <end x="2852.0437" y="2486.8496"/> </arc> <arc class="catalysis" id="modif_ced076e2-36d4-4edd-a017-41c454a8aee9" source="mpk1_mpk1_s1040_mpk1_mpk1_csa100" target="pr_65758942-a880-41bf-953a-49707313d6a0"> <start x="3217.7463" y="2065.0"/> <next x="3216.4124" y="2093.4111"/> <next x="2790.4685" y="2090.5803"/> <next x="2790.6985" y="2366.487"/> <next x="2835.703" y="2368.8708"/> <end x="2852.0437" y="2486.8496"/> </arc> <arc class="catalysis" id="modif_50845410-4c4d-4196-8dee-0419b3b05b6b" source="mpk1_mpk1_s1039_mpk1_mpk1_csa84" target="pr_65758942-a880-41bf-953a-49707313d6a0"> <start x="2855.9963" y="2042.0"/> <next x="2796.5674" y="2041.8801"/> <next x="2794.1133" y="2362.017"/> <next x="2839.687" y="2361.8264"/> <end x="2852.0437" y="2486.8496"/> </arc> <arc class="catalysis" id="modif_71760f48-0140-4d4f-872c-5fa99becbc63" source="mpk1_mpk1_s1048_mpk1_mpk1_csa91" target="pr_65758942-a880-41bf-953a-49707313d6a0"> <start x="3903.9963" y="2018.5"/> <next x="3863.5266" y="2018.6201"/> <next x="3861.8562" y="2358.0913"/> <next x="2882.2664" y="2369.8389"/> <end x="2852.0437" y="2486.8496"/> </arc> <arc class="catalysis" id="modif_0bc1020d-9bac-4308-ad0d-1171cebff39c" source="mpk1_mpk1_s1043_mpk1_mpk1_csa98" target="pr_65758942-a880-41bf-953a-49707313d6a0"> <start x="3397.9963" y="2325.0"/> <next x="3397.2053" y="2369.9917"/> <next x="2887.1475" y="2375.2144"/> <end x="2857.0437" y="2486.8625"/> </arc> <arc class="catalysis" id="modif_a724ad01-3112-43c7-a077-c681ac44e6d6" source="mpk1_mpk1_s1036_mpk1_mpk1_csa82" target="pr_65758942-a880-41bf-953a-49707313d6a0"> <start x="3676.7463" y="2323.0"/> <next x="3677.115" y="2382.6992"/> <next x="2899.7744" y="2385.4802"/> <end x="2857.0437" y="2486.8625"/> </arc> <arc class="catalysis" id="modif_d3c81f37-e5f5-4ed6-9c29-982a639cbca0" source="mpk1_mpk1_s1035_mpk1_mpk1_csa95" target="pr_65758942-a880-41bf-953a-49707313d6a0"> <start x="3903.7463" y="2317.0"/> <next x="3901.1611" y="2367.8882"/> <next x="2893.1982" y="2378.8804"/> <end x="2857.0437" y="2486.8625"/> </arc> <arc class="catalysis" id="modif_a9690135-0cb2-445d-ab0e-fc206c33f1be" source="mpk1_mpk1_s635_mpk1_mpk1_sa530" target="pr_65758942-a880-41bf-953a-49707313d6a0"> <start x="4051.5" y="2371.5"/> <next x="4048.9285" y="2470.9087"/> <next x="2879.9893" y="2460.0513"/> <end x="2857.0437" y="2486.8625"/> </arc> <arc class="consumption" id="cons_763f97b5-e880-476e-be01-f4132de12f44" source="mpk1_mpk1_s639_mpk1_mpk1_sa392" target="pr_d7c65ba3-03a5-4250-8830-03fd07a7b435_p1"> <start x="3594.9963" y="2497.5"/> <end x="3636.1782" y="2498.7727"/> </arc> <arc class="production" id="prod_a3f7774b-4e91-40ff-8a5e-40004d2c8d06" source="pr_d7c65ba3-03a5-4250-8830-03fd07a7b435_p2" target="mpk1_mpk1_s664_mpk1_mpk1_sa395"> <start x="3666.1782" y="2498.7727"/> <end x="3707.36" y="2500.0454"/> </arc> <arc class="catalysis" id="modif_20e55cff-bcfc-48ce-9308-4fcff5fb11c1" source="mpk1_mpk1_s1048_mpk1_mpk1_csa91" target="pr_d7c65ba3-03a5-4250-8830-03fd07a7b435"> <start x="4174.996" y="2040.25"/> <next x="4196.421" y="2040.6438"/> <next x="4198.219" y="2466.2053"/> <next x="3692.1785" y="2459.8184"/> <end x="3651.2915" y="2493.774"/> </arc> <arc class="catalysis" id="modif_c8c845d8-7bf7-4ab7-a8cd-88c6459cdb0e" source="mpk1_mpk1_s1043_mpk1_mpk1_csa98" target="pr_d7c65ba3-03a5-4250-8830-03fd07a7b435"> <start x="3577.9963" y="2325.0"/> <end x="3646.2927" y="2493.6606"/> </arc> <arc class="catalysis" id="modif_929edb61-006a-4299-bb03-c74794225bd5" source="mpk1_mpk1_s635_mpk1_mpk1_sa530" target="pr_d7c65ba3-03a5-4250-8830-03fd07a7b435"> <start x="4083.0" y="2371.5"/> <next x="4070.0017" y="2460.0007"/> <next x="3683.3464" y="2456.777"/> <end x="3651.2915" y="2493.774"/> </arc> <arc class="catalysis" id="modif_f0ea52d0-4797-4980-b06f-d901ede20576" source="mpk1_mpk1_s1035_mpk1_mpk1_csa95" target="pr_d7c65ba3-03a5-4250-8830-03fd07a7b435"> <start x="3935.4963" y="2317.0"/> <next x="3934.01" y="2453.1008"/> <next x="3674.7136" y="2449.768"/> <end x="3646.2927" y="2493.6606"/> </arc> <arc class="consumption" id="cons_2b9516ff-c4c8-425a-b8dd-bbd69d34785d" source="mpk1_mpk1_s665_mpk1_mpk1_sa396" target="pr_5e513f68-e7f1-439c-be3e-e1223a60ae84_p1"> <start x="3889.9963" y="2636.5"/> <end x="3770.3145" y="2634.5"/> </arc> <arc class="production" id="prod_674d06c9-d8f6-4df2-80af-469d9e91f031" source="pr_5e513f68-e7f1-439c-be3e-e1223a60ae84_p2" target="mpk1_mpk1_s675_mpk1_mpk1_sa397"> <start x="3740.3145" y="2634.5"/> <end x="3620.6328" y="2632.5"/> </arc> <arc class="catalysis" id="modif_47cc237e-0fa2-4a7b-87a8-048c04ba6885" source="mpk1_mpk1_s664_mpk1_mpk1_sa395" target="pr_5e513f68-e7f1-439c-be3e-e1223a60ae84"> <start x="3748.86" y="2512.5454"/> <end x="3750.3892" y="2629.4263"/> </arc> <arc class="catalysis" id="modif_f0760797-e69b-4fe1-ae04-0f0f6ab68d92" source="mpk1_mpk1_s681_mpk1_mpk1_sa403" target="pr_5e513f68-e7f1-439c-be3e-e1223a60ae84"> <start x="3909.9963" y="2509.3335"/> <next x="3759.8855" y="2576.393"/> <end x="3760.3882" y="2629.5747"/> </arc> <arc class="consumption" id="cons_e409aaa7-8060-4ce6-a920-39588658bb63" source="mpk1_mpk1_s676_mpk1_mpk1_sa398" target="pr_ac67f4bc-44c1-4b94-95f2-8e7cc8f83671_p1"> <start x="3156.9963" y="2593.25"/> <end x="3056.3145" y="2593.75"/> </arc> <arc class="production" id="prod_0296d242-fea8-4d92-a038-91bd0070bad3" source="pr_ac67f4bc-44c1-4b94-95f2-8e7cc8f83671_p2" target="mpk1_mpk1_s677_mpk1_mpk1_sa399"> <start x="3026.3145" y="2593.75"/> <end x="2925.6328" y="2594.25"/> </arc> <arc class="catalysis" id="modif_eccf77b7-5026-437d-ab90-0359d47acd96" source="mpk1_mpk1_s663_mpk1_mpk1_sa394" target="pr_ac67f4bc-44c1-4b94-95f2-8e7cc8f83671"> <start x="2959.269" y="2504.5454"/> <next x="3036.7473" y="2555.8464"/> <end x="3036.293" y="2588.7717"/> </arc> <arc class="catalysis" id="modif_8f800b70-b3d0-4f73-9b16-d21b43f7e637" source="mpk1_mpk1_s679_mpk1_mpk1_sa401" target="pr_ac67f4bc-44c1-4b94-95f2-8e7cc8f83671"> <start x="3369.9963" y="2511.3335"/> <next x="3371.8174" y="2561.2827"/> <next x="3045.0767" y="2553.048"/> <end x="3046.2927" y="2588.7285"/> </arc> <arc class="consumption" id="cons_e32e6838-6cfd-473f-901c-169760602733" source="mpk1_mpk1_s678_mpk1_mpk1_sa400" target="pr_1ada76cd-10ce-4378-8cfb-183178d949b2_p1"> <start x="3177.9963" y="2494.5"/> <end x="3238.2463" y="2496.6667"/> </arc> <arc class="production" id="prod_91c9d727-9796-463e-8149-4be20ec8e33e" source="pr_1ada76cd-10ce-4378-8cfb-183178d949b2_p2" target="mpk1_mpk1_s679_mpk1_mpk1_sa401"> <start x="3268.2463" y="2496.6667"/> <end x="3328.4963" y="2498.8335"/> </arc> <arc class="catalysis" id="modif_1bd25380-944c-41c9-b2f3-557077127386" source="mpk1_mpk1_s1041_mpk1_mpk1_csa89" target="pr_1ada76cd-10ce-4378-8cfb-183178d949b2"> <start x="3419.4004" y="2217.4614"/> <next x="3386.3901" y="2236.5518"/> <next x="3380.1653" y="2438.7134"/> <next x="3301.8538" y="2439.7937"/> <end x="3253.3901" y="2491.6687"/> </arc> <arc class="catalysis" id="modif_badd840d-d818-4703-9e12-f310462c3abd" source="mpk1_mpk1_s1046_mpk1_mpk1_csa90" target="pr_1ada76cd-10ce-4378-8cfb-183178d949b2"> <start x="3187.4963" y="2200.0"/> <next x="3153.5215" y="2222.2434"/> <next x="3153.58" y="2430.7585"/> <next x="3238.6316" y="2431.0955"/> <end x="3253.3901" y="2491.6687"/> </arc> <arc class="catalysis" id="modif_6ffe6341-c71c-46e5-8e6a-a66c4503bb03" source="mpk1_mpk1_s1040_mpk1_mpk1_csa100" target="pr_1ada76cd-10ce-4378-8cfb-183178d949b2"> <start x="3331.2463" y="2065.0"/> <next x="3354.5972" y="2096.3054"/> <next x="3351.3013" y="2446.454"/> <next x="3307.4917" y="2446.9832"/> <end x="3258.3882" y="2491.8127"/> </arc> <arc class="catalysis" id="modif_7513448a-0df7-47f6-843e-715b6d7dc26a" source="mpk1_mpk1_s1049_mpk1_mpk1_csa92" target="pr_1ada76cd-10ce-4378-8cfb-183178d949b2"> <start x="2990.9963" y="2329.0"/> <next x="2993.493" y="2438.3635"/> <next x="3232.5613" y="2441.1067"/> <end x="3258.3882" y="2491.8127"/> </arc> <arc class="catalysis" id="modif_57cacfef-475b-4f61-bc67-d75cd312caf7" source="mpk1_mpk1_s1042_mpk1_mpk1_csa97" target="pr_1ada76cd-10ce-4378-8cfb-183178d949b2"> <start x="3257.9963" y="2326.0"/> <end x="3253.3901" y="2491.6687"/> </arc> <arc class="catalysis" id="modif_749cca0f-f535-49f3-ad8b-00f21bdd287a" source="mpk1_mpk1_s1039_mpk1_mpk1_csa84" target="pr_1ada76cd-10ce-4378-8cfb-183178d949b2"> <start x="2855.9963" y="2015.0"/> <next x="2770.5615" y="2012.4495"/> <next x="2767.3572" y="2424.5835"/> <next x="3243.8684" y="2428.5286"/> <end x="3253.3901" y="2491.6687"/> </arc> <arc class="catalysis" id="modif_54fb5934-bdaf-4abb-85fe-7f46ab99ae57" source="mpk1_mpk1_s1045_mpk1_mpk1_csa94" target="pr_1ada76cd-10ce-4378-8cfb-183178d949b2"> <start x="2834.9963" y="2140.75"/> <next x="2761.6035" y="2140.513"/> <next x="2762.265" y="2430.7842"/> <next x="3236.1162" y="2435.8484"/> <end x="3253.3901" y="2491.6687"/> </arc> <arc class="catalysis" id="modif_fd412d0b-9f14-4868-a611-79c40530ae44" source="mpk1_mpk1_s1048_mpk1_mpk1_csa91" target="pr_1ada76cd-10ce-4378-8cfb-183178d949b2"> <start x="3971.7463" y="2062.0"/> <next x="3971.1555" y="2082.3333"/> <next x="3837.8523" y="2085.0508"/> <next x="3837.5364" y="2436.2375"/> <next x="3297.2605" y="2432.267"/> <end x="3253.3901" y="2491.6687"/> </arc> <arc class="catalysis" id="modif_0eac580f-516d-4310-9b7a-a33cd7f271ef" source="mpk1_mpk1_s1043_mpk1_mpk1_csa98" target="pr_1ada76cd-10ce-4378-8cfb-183178d949b2"> <start x="3442.9963" y="2325.0"/> <next x="3444.8577" y="2428.9673"/> <next x="3292.3298" y="2426.9656"/> <end x="3253.3901" y="2491.6687"/> </arc> <arc class="catalysis" id="modif_af5ebc22-1601-4d05-83d1-43f0b4109f52" source="mpk1_mpk1_s635_mpk1_mpk1_sa530" target="pr_1ada76cd-10ce-4378-8cfb-183178d949b2"> <start x="4067.25" y="2371.5"/> <next x="4060.0005" y="2440.001"/> <next x="3399.9912" y="2440.0076"/> <end x="3258.3882" y="2491.8127"/> </arc> <arc class="consumption" id="cons_dc3f99a3-a262-49e8-8138-3576f0a26e5a" source="mpk1_mpk1_s680_mpk1_mpk1_sa402" target="pr_2a54d312-2cde-4e92-9dcb-8bc7e9f2d7c7_p1"> <start x="4067.996" y="2496.5"/> <end x="4024.746" y="2496.6667"/> </arc> <arc class="production" id="prod_a0a0b0cd-0eda-4b61-adcf-c7c32549c6f6" source="pr_2a54d312-2cde-4e92-9dcb-8bc7e9f2d7c7_p2" target="mpk1_mpk1_s681_mpk1_mpk1_sa403"> <start x="3994.746" y="2496.6667"/> <end x="3951.4963" y="2496.8335"/> </arc> <arc class="catalysis" id="modif_7fe0675e-0e3e-4859-9caa-0477024b90c3" source="mpk1_mpk1_s1040_mpk1_mpk1_csa100" target="pr_2a54d312-2cde-4e92-9dcb-8bc7e9f2d7c7"> <start x="3387.9963" y="2065.0"/> <next x="3362.765" y="2095.7173"/> <next x="3362.2441" y="2413.2017"/> <next x="3950.4705" y="2420.271"/> <end x="4004.7317" y="2491.6812"/> </arc> <arc class="catalysis" id="modif_2e9c55fd-2bb1-4e94-b59d-40ff9fd3344a" source="mpk1_mpk1_s1049_mpk1_mpk1_csa92" target="pr_2a54d312-2cde-4e92-9dcb-8bc7e9f2d7c7"> <start x="3063.9963" y="2329.0"/> <next x="3061.7463" y="2401.5737"/> <next x="3963.3972" y="2410.2869"/> <end x="4004.7317" y="2491.6812"/> </arc> <arc class="catalysis" id="modif_9df85631-e088-469e-bfe4-d29f3d370aa0" source="mpk1_mpk1_s1047_mpk1_mpk1_csa93" target="pr_2a54d312-2cde-4e92-9dcb-8bc7e9f2d7c7"> <start x="3775.2463" y="1984.0"/> <next x="3774.3718" y="1970.2988"/> <next x="4237.24" y="1968.0907"/> <next x="4232.4546" y="2416.2063"/> <next x="4036.123" y="2418.1628"/> <end x="4004.7317" y="2491.6812"/> </arc> <arc class="catalysis" id="modif_92a7f20c-380e-4859-a0a6-6fb88f0429f2" source="mpk1_mpk1_s1045_mpk1_mpk1_csa94" target="pr_2a54d312-2cde-4e92-9dcb-8bc7e9f2d7c7"> <start x="2834.9963" y="2182.25"/> <next x="2805.9634" y="2180.2822"/> <next x="2803.5552" y="2396.8877"/> <next x="3912.9946" y="2403.4211"/> <end x="4014.7317" y="2491.6523"/> </arc> <arc class="catalysis" id="modif_7a07332b-c183-44c2-80aa-fbc0d8609c3e" source="mpk1_mpk1_s1044_mpk1_mpk1_csa85" target="pr_2a54d312-2cde-4e92-9dcb-8bc7e9f2d7c7"> <start x="3714.4963" y="2181.0"/> <next x="3713.9888" y="2207.2627"/> <next x="4237.358" y="2208.316"/> <next x="4237.812" y="2420.8306"/> <next x="4043.5186" y="2421.769"/> <end x="4009.7317" y="2491.6667"/> </arc> <arc class="catalysis" id="modif_03f5f594-2475-45d2-bc12-b16491dc574a" source="mpk1_mpk1_s1048_mpk1_mpk1_csa91" target="pr_2a54d312-2cde-4e92-9dcb-8bc7e9f2d7c7"> <start x="4174.996" y="2018.5"/> <next x="4220.4756" y="2019.0332"/> <next x="4219.5176" y="2408.6047"/> <next x="4019.1016" y="2407.685"/> <end x="4009.7317" y="2491.6667"/> </arc> <arc class="catalysis" id="modif_40587a77-03d9-4bc0-aa7e-65d79882a8ac" source="mpk1_mpk1_s1043_mpk1_mpk1_csa98" target="pr_2a54d312-2cde-4e92-9dcb-8bc7e9f2d7c7"> <start x="3487.9963" y="2325.0"/> <next x="3488.772" y="2410.3982"/> <next x="3956.7861" y="2414.3481"/> <end x="4009.7317" y="2491.6667"/> </arc> <arc class="catalysis" id="modif_d3a60927-5002-445b-8ba1-3bf8472a320b" source="mpk1_mpk1_s1038_mpk1_mpk1_csa83" target="pr_2a54d312-2cde-4e92-9dcb-8bc7e9f2d7c7"> <start x="4141.996" y="2142.0"/> <next x="4227.1133" y="2142.331"/> <next x="4227.6567" y="2412.227"/> <next x="4027.307" y="2413.2146"/> <end x="4004.7317" y="2491.6812"/> </arc> <arc class="catalysis" id="modif_77912a0b-9c2a-4ec1-b9d9-ad1956ec7e25" source="mpk1_mpk1_s1036_mpk1_mpk1_csa82" target="pr_2a54d312-2cde-4e92-9dcb-8bc7e9f2d7c7"> <start x="3726.4963" y="2323.0"/> <next x="3728.2012" y="2423.5398"/> <next x="3946.6663" y="2424.9902"/> <end x="4009.7317" y="2491.6667"/> </arc> <arc class="catalysis" id="modif_16a576c4-936e-4252-b18c-febed9e001c3" source="mpk1_mpk1_s1035_mpk1_mpk1_csa95" target="pr_2a54d312-2cde-4e92-9dcb-8bc7e9f2d7c7"> <start x="3967.2463" y="2317.0"/> <end x="4004.7317" y="2491.6812"/> </arc> <arc class="catalysis" id="modif_cae10805-fb0d-4a30-a6c5-53026e259fd0" source="mpk1_mpk1_s635_mpk1_mpk1_sa530" target="pr_2a54d312-2cde-4e92-9dcb-8bc7e9f2d7c7"> <start x="4098.75" y="2371.5"/> <next x="4089.998" y="2430.0054"/> <next x="4049.9941" y="2430.0046"/> <end x="4014.7317" y="2491.6523"/> </arc> <arc class="consumption" id="cons_4fe6bce6-9326-41ea-a44a-1f940ae0636a" source="mpk1_mpk1_s174_mpk1_mpk1_sa64" target="pr_255b428c-6689-42bf-a272-70c52fa8f178_p1"> <start x="2165.0" y="2598.25"/> <end x="2221.0835" y="2598.6667"/> </arc> <arc class="production" id="prod_a345ad40-f3ab-4bf0-ba8d-194974d4cafb" source="pr_255b428c-6689-42bf-a272-70c52fa8f178_p2" target="mpk1_mpk1_s603_mpk1_mpk1_sa259"> <start x="2251.0835" y="2598.6667"/> <end x="2307.1667" y="2599.0835"/> </arc> <arc class="catalysis" id="modif_01afd176-9e6c-4806-80b2-e613af9814e8" source="mpk1_mpk1_s799_mpk1_mpk1_sa554" target="pr_255b428c-6689-42bf-a272-70c52fa8f178"> <start x="2034.9404" y="2675.6904"/> <next x="2063.1785" y="2680.0017"/> <next x="2062.3242" y="2634.8372"/> <next x="2207.6863" y="2634.987"/> <end x="2231.1128" y="2593.6375"/> </arc> <arc class="consumption" id="cons_6f886df6-da71-497e-9c83-956ead88ed8b" source="mpk1_mpk1_s688_mpk1_mpk1_sa412" target="pr_f04e9d60-45bf-4a6c-9290-9eb2a4050591_p1"> <start x="3846.9963" y="2747.5"/> <end x="3805.0796" y="2781.5"/> </arc> <arc class="production" id="prod_78b34da9-4297-45b3-9816-878a24429066" source="pr_f04e9d60-45bf-4a6c-9290-9eb2a4050591_p2" target="mpk1_mpk1_s689_mpk1_mpk1_sa413"> <start x="3775.0796" y="2781.5"/> <end x="3733.163" y="2815.5"/> </arc> <arc class="catalysis" id="modif_e8ae7c76-9e9b-4195-89b6-be768475a7b9" source="mpk1_mpk1_s675_mpk1_mpk1_sa397" target="pr_f04e9d60-45bf-4a6c-9290-9eb2a4050591"> <start x="3620.6328" y="2638.75"/> <end x="3787.5154" y="2777.2075"/> </arc> <arc class="consumption" id="cons_d7652702-d2e8-49d0-b63e-8a79cc36c799" source="mpk1_mpk1_s690_mpk1_mpk1_sa414" target="pr_17122180-1232-4aa2-b0f9-6a47bdf97531_p1"> <start x="4047.9963" y="2955.0"/> <end x="3985.5796" y="2993.5"/> </arc> <arc class="production" id="prod_54619576-5eec-44a2-b25a-cdc51daa403b" source="pr_17122180-1232-4aa2-b0f9-6a47bdf97531_p2" target="mpk1_mpk1_s691_mpk1_mpk1_sa415"> <start x="3955.5796" y="2993.5"/> <end x="3893.163" y="3032.0"/> </arc> <arc class="catalysis" id="modif_3c46db1e-e7b7-400b-9393-1649282b91a7" source="mpk1_mpk1_s689_mpk1_mpk1_sa413" target="pr_17122180-1232-4aa2-b0f9-6a47bdf97531"> <start x="3690.663" y="2828.0"/> <next x="3689.975" y="2839.9924"/> <next x="3969.8286" y="2840.583"/> <end x="3968.3533" y="2989.023"/> </arc> <arc class="consumption" id="cons_0c8d33b5-2632-4ba4-9dba-4ee2a6b4cb38" source="mpk1_mpk1_s692_mpk1_mpk1_sa416" target="pr_ac2d3ac4-dd71-4a3e-bbb2-d0fbf670a59f_p1"> <start x="2193.9963" y="2682.0"/> <end x="2193.0796" y="2711.1667"/> </arc> <arc class="production" id="prod_3bb7f2d3-38c9-42b0-9c64-a0ba40e7c99e" source="pr_ac2d3ac4-dd71-4a3e-bbb2-d0fbf670a59f_p2" target="mpk1_mpk1_s693_mpk1_mpk1_sa417"> <start x="2193.0796" y="2741.1667"/> <end x="2192.163" y="2770.3335"/> </arc> <arc class="catalysis" id="modif_8b5da278-e335-4491-82ba-41c0cbf8d330" source="mpk1_mpk1_s675_mpk1_mpk1_sa397" target="pr_ac2d3ac4-dd71-4a3e-bbb2-d0fbf670a59f"> <start x="3583.1328" y="2645.0"/> <next x="3582.0493" y="2726.7524"/> <end x="2197.9749" y="2731.2693"/> </arc> <arc class="catalysis" id="modif_eee6d74a-df51-4811-82c0-fabf3107d02d" source="mpk1_mpk1_s603_mpk1_mpk1_sa259" target="pr_ac2d3ac4-dd71-4a3e-bbb2-d0fbf670a59f"> <start x="2319.6667" y="2617.8335"/> <next x="2310.8318" y="2721.8518"/> <end x="2198.0786" y="2726.2705"/> </arc> <arc class="consumption" id="cons_4106b3a1-cf00-4fee-b5c5-0b3089ca84dd" source="mpk1_mpk1_s694_mpk1_mpk1_sa418" target="pr_96184df0-cf1e-45c3-9428-700100b61dac_p1"> <start x="2952.9963" y="2692.0"/> <end x="2953.5796" y="2732.1667"/> </arc> <arc class="production" id="prod_879a905a-9591-481d-9d5d-b549fc847a5a" source="pr_96184df0-cf1e-45c3-9428-700100b61dac_p2" target="mpk1_mpk1_s695_mpk1_mpk1_sa419"> <start x="2953.5796" y="2762.1667"/> <end x="2954.163" y="2802.3335"/> </arc> <arc class="catalysis" id="modif_f3294017-450e-40f7-895e-d1fd8c174901" source="mpk1_mpk1_s675_mpk1_mpk1_sa397" target="pr_96184df0-cf1e-45c3-9428-700100b61dac"> <start x="3608.1328" y="2645.0"/> <next x="3608.045" y="2692.5881"/> <next x="3005.9858" y="2698.9775"/> <next x="3006.0374" y="2746.2327"/> <end x="2958.5793" y="2747.1138"/> </arc> <arc class="consumption" id="cons_3e8c3b9b-8fe6-4c51-824e-23cd4624d3be" source="mpk1_mpk1_s697_mpk1_mpk1_sa421" target="pr_48d189ee-ff15-42d6-91aa-b30ede85a3d0_p1"> <start x="3159.4963" y="2932.0"/> <end x="3158.913" y="2998.1667"/> </arc> <arc class="production" id="prod_2b28d566-30d2-4ca0-bfad-e90b4a76c4dc" source="pr_48d189ee-ff15-42d6-91aa-b30ede85a3d0_p2" target="mpk1_mpk1_s698_mpk1_mpk1_sa422"> <start x="3158.913" y="3028.1667"/> <end x="3158.3298" y="3094.3335"/> </arc> <arc class="catalysis" id="modif_cc8165a8-6468-48d4-b609-f6139d01fa0c" source="mpk1_mpk1_s795_mpk1_mpk1_sa550" target="pr_48d189ee-ff15-42d6-91aa-b30ede85a3d0"> <start x="2987.7144" y="2938.2856"/> <next x="2990.536" y="3004.6772"/> <end x="3153.8772" y="3018.1306"/> </arc> <arc class="consumption" id="cons_bb145977-62d3-42c9-a217-536d4dd1f35e" source="mpk1_mpk1_s781_mpk1_mpk1_sa423" target="pr_830995f4-455d-4580-8a8b-c2db177c1bb7_p1"> <start x="2527.9963" y="2765.0"/> <end x="2554.5796" y="2765.5833"/> </arc> <arc class="production" id="prod_8a950ce8-aa75-4f6e-9c10-fcb6616aac34" source="pr_830995f4-455d-4580-8a8b-c2db177c1bb7_p2" target="mpk1_mpk1_s700_mpk1_mpk1_sa424"> <start x="2584.5796" y="2765.5833"/> <end x="2611.163" y="2766.1665"/> </arc> <arc class="catalysis" id="modif_e7ed3ff5-7d78-48bc-a35f-311868334863" source="mpk1_mpk1_s677_mpk1_mpk1_sa399" target="pr_830995f4-455d-4580-8a8b-c2db177c1bb7"> <start x="2875.6328" y="2600.5"/> <end x="2574.6492" y="2760.6538"/> </arc> <arc class="consumption" id="cons_b7569eff-f3b3-4fe5-bbc9-1e995c287049" source="mpk1_mpk1_s781_mpk1_mpk1_sa423" target="pr_9cf2535a-cff4-449d-a704-8c8477c625eb_p1"> <start x="2497.4963" y="2777.0"/> <next x="2497.68" y="2823.5505"/> <end x="2281.112" y="2829.1357"/> </arc> <arc class="production" id="prod_d5146125-2fd4-44a5-b654-6ac2bb75f46b" source="pr_9cf2535a-cff4-449d-a704-8c8477c625eb_p2" target="mpk1_mpk1_s780_mpk1_mpk1_sa425"> <start x="2251.112" y="2829.1357"/> <next x="2034.5441" y="2834.7212"/> <end x="2035.6631" y="2923.0"/> </arc> <arc class="consumption" id="cons_e53c66ee-f852-4229-914d-fde1f87ab6c7" source="mpk1_mpk1_s725_mpk1_mpk1_sa537" target="pr_8eb836e1-a7d3-4076-af91-6848bc19adee_p1"> <start x="2152.663" y="3076.3335"/> <next x="2152.9963" y="3127.1406"/> <end x="1993.9963" y="3129.0928"/> </arc> <arc class="consumption" id="cons_a27bacd2-89dc-45bc-a6d1-ad038f52ea6d" source="mpk1_mpk1_s726_mpk1_mpk1_sa538" target="pr_8eb836e1-a7d3-4076-af91-6848bc19adee_p1"> <start x="2455.0" y="3130.0"/> <next x="2152.9963" y="3127.1406"/> <end x="1993.9963" y="3129.0928"/> </arc> <arc class="production" id="prod_5ff6c481-2756-42ac-a5be-da51889a3f71" source="pr_8eb836e1-a7d3-4076-af91-6848bc19adee_p2" target="mpk1_mpk1_s1050_mpk1_mpk1_csa105"> <start x="1963.9963" y="3129.0928"/> <end x="1808.9965" y="3131.0"/> </arc> <arc class="consumption" id="cons_55e16210-34b7-4389-8eed-bc53d00fe959" source="mpk1_mpk1_s725_mpk1_mpk1_sa537" target="pr_2e2b64dd-ddf5-4312-921c-95910e772b30_p1"> <start x="2115.163" y="3063.8335"/> <next x="1717.6079" y="3053.9714"/> <end x="1717.5522" y="3019.4858"/> </arc> <arc class="production" id="prod_c9eb6f72-a877-4fda-8632-ca169144a810" source="pr_2e2b64dd-ddf5-4312-921c-95910e772b30_p2" target="mpk1_mpk1_s1051_mpk1_mpk1_csa103"> <start x="1717.5522" y="2989.4858"/> <end x="1717.4965" y="2955.0"/> </arc> <arc class="consumption" id="cons_34fdd97d-725f-40fa-ba4d-85835e377b98" source="mpk1_mpk1_s725_mpk1_mpk1_sa537" target="pr_44de867b-5ce8-48e2-8d0c-9b7c32301371_p1"> <start x="2127.663" y="3076.3335"/> <next x="2125.905" y="3166.418"/> <next x="1571.498" y="3167.0007"/> <end x="1570.2021" y="3124.5005"/> </arc> <arc class="consumption" id="cons_df1ce631-001e-4fd1-bc5a-28cb729ab44b" source="mpk1_mpk1_s723_mpk1_mpk1_sa536" target="pr_44de867b-5ce8-48e2-8d0c-9b7c32301371_p1"> <start x="1152.1631" y="3054.3335"/> <next x="1152.5775" y="3166.85"/> <next x="1571.498" y="3167.0007"/> <end x="1570.2021" y="3124.5005"/> </arc> <arc class="production" id="prod_fc145308-2de3-43c9-8e57-a21d5ac5fae6" source="pr_44de867b-5ce8-48e2-8d0c-9b7c32301371_p2" target="mpk1_mpk1_s1052_mpk1_mpk1_csa104"> <start x="1570.2021" y="3094.5005"/> <end x="1568.9965" y="3056.0"/> </arc> <arc class="consumption" id="cons_a3d1742e-a4db-4e76-a007-c6ba1643c6a4" source="mpk1_mpk1_s702_mpk1_mpk1_sa427" target="pr_71e59444-3209-491b-a704-4dce0228933e_p1"> <start x="2480.0" y="2932.5"/> <end x="2480.0" y="3010.0"/> </arc> <arc class="production" id="prod_11c52cb0-d61f-460e-be4d-77373aa4decc" source="pr_71e59444-3209-491b-a704-4dce0228933e_p2" target="mpk1_mpk1_s726_mpk1_mpk1_sa538"> <start x="2480.0" y="3040.0"/> <end x="2480.0" y="3117.5"/> </arc> <arc class="catalysis" id="modif_79f8b3d5-224b-4744-a49a-d04a9d4f1c5d" source="mpk1_mpk1_s795_mpk1_mpk1_sa550" target="pr_71e59444-3209-491b-a704-4dce0228933e"> <start x="2937.7144" y="2932.0356"/> <next x="2840.1592" y="3021.9492"/> <end x="2485.0" y="3025.0"/> </arc> <arc class="catalysis" id="modif_22363dfb-23ff-4b32-815f-f48c5071c58d" source="mpk1_mpk1_s796_mpk1_mpk1_sa551" target="pr_71e59444-3209-491b-a704-4dce0228933e"> <start x="2398.5715" y="2919.1428"/> <end x="2475.0" y="3020.0"/> </arc> <arc class="consumption" id="cons_bf86db73-87fc-4109-95f2-79e3c0b9f3da" source="mpk1_mpk1_s379_mpk1_mpk1_sa254" target="pr_5640f81d-296c-48e9-ae43-ab06cb092284_p1"> <start x="1151.0" y="2906.0"/> <end x="1151.5815" y="2952.6667"/> </arc> <arc class="production" id="prod_0f3103ed-934e-47e9-a55d-2093321ed86e" source="pr_5640f81d-296c-48e9-ae43-ab06cb092284_p2" target="mpk1_mpk1_s723_mpk1_mpk1_sa536"> <start x="1151.5815" y="2982.6667"/> <end x="1152.1631" y="3029.3335"/> </arc> <arc class="catalysis" id="modif_eb71f4d8-d764-48b4-a877-fda0f45861d9" source="mpk1_mpk1_s558_mpk1_mpk1_sa325" target="pr_5640f81d-296c-48e9-ae43-ab06cb092284"> <start x="1278.1666" y="2892.0835"/> <end x="1156.5813" y="2967.6196"/> </arc> <arc class="catalysis" id="modif_1a725d98-dac7-4c04-a530-e2d45c08b1ac" source="mpk1_mpk1_s387_mpk1_mpk1_sa260" target="pr_5640f81d-296c-48e9-ae43-ab06cb092284"> <start x="808.6667" y="2910.5"/> <next x="814.0501" y="2958.7344"/> <end x="1146.5818" y="2967.7139"/> </arc> <arc class="consumption" id="cons_19219f23-d5e3-497a-9a0f-73838efe4190" source="mpk1_mpk1_s701_mpk1_mpk1_sa426" target="pr_ef7777db-9aa7-491a-97a7-4c4ebc5d164b_p1"> <start x="2144.9963" y="2939.0"/> <end x="2142.5796" y="2980.1667"/> </arc> <arc class="production" id="prod_fd951156-acfd-4086-94b3-37484a842d4c" source="pr_ef7777db-9aa7-491a-97a7-4c4ebc5d164b_p2" target="mpk1_mpk1_s725_mpk1_mpk1_sa537"> <start x="2142.5796" y="3010.1667"/> <end x="2140.163" y="3051.3335"/> </arc> <arc class="catalysis" id="modif_21625d11-432e-4851-ba38-1d6a6e00165b" source="mpk1_mpk1_s796_mpk1_mpk1_sa551" target="pr_ef7777db-9aa7-491a-97a7-4c4ebc5d164b"> <start x="2361.0715" y="2919.1428"/> <next x="2361.7292" y="2991.72"/> <end x="2147.575" y="2995.3816"/> </arc> <arc class="consumption" id="cons_7be7c2bf-2dca-41e8-b3de-6282aa987807" source="mpk1_mpk1_s786_mpk1_mpk1_sa543" target="pr_9c3f1a12-52f8-446d-8052-7e4658308dbe_p1"> <start x="3353.5" y="2925.0"/> <end x="3355.8572" y="2987.4287"/> </arc> <arc class="production" id="prod_b365c845-2601-42f1-9d21-4567755693ce" source="pr_9c3f1a12-52f8-446d-8052-7e4658308dbe_p2" target="mpk1_mpk1_s787_mpk1_mpk1_sa544"> <start x="3355.8572" y="3017.4287"/> <end x="3358.2144" y="3079.8572"/> </arc> <arc class="catalysis" id="modif_e7cc51ae-28f3-4e14-acf7-6513beac8469" source="mpk1_mpk1_s795_mpk1_mpk1_sa550" target="pr_9c3f1a12-52f8-446d-8052-7e4658308dbe"> <start x="2987.7144" y="2925.7856"/> <next x="3092.8926" y="2987.5422"/> <end x="3350.8594" y="3002.5808"/> </arc> <arc class="catalysis" id="modif_4983e429-bf14-4199-bc18-f4ff774c8b37" source="mpk1_mpk1_s922_mpk1_mpk1_sa678" target="pr_9c3f1a12-52f8-446d-8052-7e4658308dbe"> <start x="4215.0" y="2571.0"/> <next x="4230.0" y="2569.9998"/> <next x="4230.0044" y="2889.9983"/> <next x="3310.009" y="2890.011"/> <next x="3310.0103" y="2990.0105"/> <end x="3350.7073" y="2997.5833"/> </arc> <arc class="consumption" id="cons_582fc0b6-12d2-4587-aff6-aef349027f01" source="mpk1_mpk1_s797_mpk1_mpk1_sa552" target="pr_0e42e6eb-cbd5-425c-a99a-399be747ccc3_p1"> <start x="2674.2856" y="2887.6428"/> <next x="2477.8303" y="2889.1643"/> <next x="2376.0" y="2964.0"/> <end x="2375.2007" y="2981.5"/> </arc> <arc class="consumption" id="cons_c440d072-9751-4c7f-894c-3abb1fac5e3a" source="mpk1_mpk1_s796_mpk1_mpk1_sa551" target="pr_0e42e6eb-cbd5-425c-a99a-399be747ccc3_p1"> <start x="2373.5715" y="2919.1428"/> <next x="2376.0" y="2964.0"/> <end x="2375.2007" y="2981.5"/> </arc> <arc class="production" id="prod_f25e5688-515c-4ce3-b0c1-bb51186b50d4" source="pr_0e42e6eb-cbd5-425c-a99a-399be747ccc3_p2" target="mpk1_mpk1_s1024_mpk1_mpk1_csa106"> <start x="2375.2007" y="3011.5"/> <end x="2374.5" y="3025.0"/> </arc> <arc class="consumption" id="cons_161fbbc0-1409-49be-9f09-5945726dec0f" source="mpk1_mpk1_s797_mpk1_mpk1_sa552" target="pr_ee245b53-2430-427d-9961-87cced843c8e_p1"> <start x="2711.7856" y="2900.1428"/> <next x="2929.6328" y="3002.0"/> <end x="2919.2856" y="3013.5"/> </arc> <arc class="consumption" id="cons_9e2a5896-5dad-4753-b21f-67b71da2a76a" source="mpk1_mpk1_s795_mpk1_mpk1_sa550" target="pr_ee245b53-2430-427d-9961-87cced843c8e_p1"> <start x="2962.7144" y="2938.2856"/> <next x="2929.6328" y="3002.0"/> <end x="2919.2856" y="3013.5"/> </arc> <arc class="production" id="prod_ee3b8389-bb04-434c-ad12-cf2be6bdf2e1" source="pr_ee245b53-2430-427d-9961-87cced843c8e_p2" target="mpk1_mpk1_s1025_mpk1_mpk1_csa107"> <start x="2919.2856" y="3043.5"/> <end x="2910.5" y="3051.0"/> </arc> <arc class="consumption" id="cons_098d541c-ca06-4691-9fc1-194b618ede55" source="mpk1_mpk1_s675_mpk1_mpk1_sa397" target="pr_94799ed5-2282-4597-afbb-241280c3a64e_p1"> <start x="3595.6328" y="2645.0"/> <next x="3597.1016" y="2835.3525"/> <end x="3301.516" y="2835.5918"/> </arc> <arc class="production" id="prod_4235c358-a03a-484b-a624-2e6d1c3f6490" source="pr_94799ed5-2282-4597-afbb-241280c3a64e_p2" target="mpk1_mpk1_s795_mpk1_mpk1_sa550"> <start x="3271.516" y="2835.5918"/> <next x="2975.9304" y="2835.831"/> <end x="2975.2144" y="2913.2856"/> </arc> <arc class="consumption" id="cons_bf3f784d-88d7-437a-8e96-3d2c1393bd8a" source="mpk1_mpk1_s677_mpk1_mpk1_sa399" target="pr_8f4ac7af-bce3-4482-af6f-87a66e3605e2_p1"> <start x="2900.6328" y="2613.0"/> <next x="2903.9045" y="2834.7393"/> <end x="2654.565" y="2834.611"/> </arc> <arc class="production" id="prod_e5d1b705-f858-4c6e-a84a-d7c10deeb206" source="pr_8f4ac7af-bce3-4482-af6f-87a66e3605e2_p2" target="mpk1_mpk1_s796_mpk1_mpk1_sa551"> <start x="2624.565" y="2834.611"/> <next x="2375.225" y="2834.483"/> <end x="2373.5715" y="2894.1428"/> </arc> <arc class="consumption" id="cons_23d74376-fab0-493e-a065-575a2cec4417" source="mpk1_mpk1_s797_mpk1_mpk1_sa552" target="pr_021d72a8-e7c4-4eb8-b71f-284dd0b69aa9_p1"> <start x="2699.2856" y="2900.1428"/> <end x="2721.6428" y="2963.0713"/> </arc> <arc class="production" id="prod_01eb38ea-dee9-491c-ade6-be006d423d23" source="pr_021d72a8-e7c4-4eb8-b71f-284dd0b69aa9_p2" target="mpk1_mpk1_s788_mpk1_mpk1_sa545"> <start x="2721.6428" y="2993.0713"/> <end x="2744.0" y="3056.0"/> </arc> <arc class="catalysis" id="modif_f34f09ee-7d59-43ed-8c41-3997f635ffc4" source="mpk1_mpk1_s600_mpk1_mpk1_sa388" target="pr_021d72a8-e7c4-4eb8-b71f-284dd0b69aa9"> <start x="3063.9963" y="1923.0"/> <next x="2824.6836" y="1919.8826"/> <next x="2828.4895" y="2979.1694"/> <end x="2726.449" y="2976.6924"/> </arc> <arc class="consumption" id="cons_c700a417-4397-4aa8-8a3c-a8eac154744a" source="mpk1_mpk1_s371_mpk1_mpk1_sa248" target="pr_a74ed071-feba-472c-aee5-656ab88fd256_p1"> <start x="951.5" y="3006.0"/> <end x="950.5357" y="3034.0713"/> </arc> <arc class="production" id="prod_478aa645-b48b-46b1-8921-335fb78520b6" source="pr_a74ed071-feba-472c-aee5-656ab88fd256_p2" target="mpk1_mpk1_s798_mpk1_mpk1_sa553"> <start x="950.5357" y="3064.0713"/> <end x="949.5714" y="3092.1428"/> </arc> <arc class="catalysis" id="modif_b8ee1b94-dfec-4f96-9dc9-230b9bdbf833" source="mpk1_mpk1_s600_mpk1_mpk1_sa388" target="pr_a74ed071-feba-472c-aee5-656ab88fd256"> <start x="3112.3901" y="1911.4515"/> <next x="3115.889" y="1782.0148"/> <next x="4247.034" y="1787.0618"/> <next x="4247.256" y="2535.0037"/> <next x="3401.4258" y="2536.314"/> <next x="3407.7727" y="3211.2185"/> <next x="1043.1252" y="3212.3833"/> <next x="1042.7185" y="3048.6213"/> <end x="955.5344" y="3049.183"/> </arc> <arc class="consumption" id="cons_3c8da5a3-6fdc-4ad3-8da0-7c37f2aff550" source="mpk1_mpk1_s327_mpk1_mpk1_sa264" target="pr_6ba68a64-1134-404d-8d06-ee02e19ff715_p1"> <start x="2022.5" y="2542.5"/> <end x="2022.4702" y="2587.8452"/> </arc> <arc class="production" id="prod_822269bc-cfc8-4ed4-bcb3-f5396dfdd265" source="pr_6ba68a64-1134-404d-8d06-ee02e19ff715_p2" target="mpk1_mpk1_s799_mpk1_mpk1_sa554"> <start x="2022.4702" y="2617.8452"/> <end x="2022.4404" y="2663.1904"/> </arc> <arc class="catalysis" id="modif_34bf56d0-2e51-4f24-8b3c-8660188fefb7" source="mpk1_mpk1_s1039_mpk1_mpk1_csa84" target="pr_6ba68a64-1134-404d-8d06-ee02e19ff715"> <start x="2855.9963" y="2069.0"/> <next x="2738.3188" y="2068.5737"/> <next x="2736.4849" y="2295.4143"/> <next x="2610.326" y="2298.7053"/> <next x="2613.6147" y="2638.143"/> <next x="2040.8785" y="2644.1025"/> <end x="2027.4702" y="2602.8477"/> </arc> <arc class="catalysis" id="modif_ee759f3f-c355-4ffd-87f6-8abeb55c41ed" source="mpk1_mpk1_s1049_mpk1_mpk1_csa92" target="pr_6ba68a64-1134-404d-8d06-ee02e19ff715"> <start x="2844.9963" y="2307.5"/> <next x="2778.8916" y="2306.9634"/> <next x="2776.6277" y="2561.6353"/> <next x="2030.6119" y="2567.8416"/> <end x="2027.4727" y="2597.8477"/> </arc> <arc class="catalysis" id="modif_90c7fdd6-dc25-4146-b793-27b1c6974928" source="mpk1_mpk1_s1045_mpk1_mpk1_csa94" target="pr_6ba68a64-1134-404d-8d06-ee02e19ff715"> <start x="2834.9963" y="2161.5"/> <next x="2751.384" y="2160.8438"/> <next x="2749.3875" y="2554.6812"/> <next x="2027.2258" y="2560.4924"/> <end x="2027.4727" y="2597.8477"/> </arc> <arc class="catalysis" id="modif_a4fa1b4c-a082-4d1a-a9f9-de58e99a7d70" source="mpk1_mpk1_s1040_mpk1_mpk1_csa100" target="pr_6ba68a64-1134-404d-8d06-ee02e19ff715"> <start x="3274.4963" y="2065.0"/> <next x="3274.7402" y="2076.406"/> <next x="2748.047" y="2076.435"/> <next x="2745.0361" y="2551.5347"/> <next x="2025.0078" y="2557.1187"/> <end x="2027.4727" y="2597.8477"/> </arc> <arc class="catalysis" id="modif_a8e83d5d-e0ff-4d0c-a7f6-692079c22c1b" source="mpk1_mpk1_s965_mpk1_mpk1_sa712" target="pr_6ba68a64-1134-404d-8d06-ee02e19ff715"> <start x="1948.5" y="2235.0"/> <next x="1878.3011" y="2259.0576"/> <next x="1883.3464" y="2591.1216"/> <end x="2017.4727" y="2597.8428"/> </arc> <arc class="consumption" id="cons_0e1aab47-18bc-4993-afa6-d36f29a75765" source="mpk1_mpk1_s603_mpk1_mpk1_sa259" target="pr_08ace191-fcf5-4f26-aeeb-64ed25349fc1_p1"> <start x="2307.1667" y="2617.8335"/> <end x="2251.0835" y="2617.4167"/> </arc> <arc class="production" id="prod_7e5507ca-d1b9-4510-9a61-767907c66932" source="pr_08ace191-fcf5-4f26-aeeb-64ed25349fc1_p2" target="mpk1_mpk1_s174_mpk1_mpk1_sa64"> <start x="2221.0835" y="2617.4167"/> <end x="2165.0" y="2617.0"/> </arc> <arc class="catalysis" id="modif_c00ae00b-b373-4aed-860f-663d5049ea43" source="mpk1_mpk1_s725_mpk1_mpk1_sa537" target="pr_08ace191-fcf5-4f26-aeeb-64ed25349fc1"> <start x="2165.163" y="3063.8335"/> <next x="2222.5208" y="3061.9424"/> <end x="2241.0542" y="2622.446"/> </arc> <arc class="catalysis" id="modif_ff94c296-d48a-47ad-be22-9ea375e7e8d7" source="mpk1_mpk1_s675_mpk1_mpk1_sa397" target="pr_08ace191-fcf5-4f26-aeeb-64ed25349fc1"> <start x="3620.6328" y="2645.0"/> <next x="3621.0374" y="2862.3857"/> <next x="2235.9866" y="2864.267"/> <end x="2241.0542" y="2622.446"/> </arc> <arc class="catalysis" id="modif_faed0681-75fd-46ef-85b0-96802a2c48d6" source="mpk1_mpk1_s1052_mpk1_mpk1_csa104" target="pr_08ace191-fcf5-4f26-aeeb-64ed25349fc1"> <start x="1622.9965" y="3034.0"/> <next x="2216.736" y="3033.9453"/> <end x="2241.0542" y="2622.446"/> </arc> <arc class="catalysis" id="modif_8881aa37-d082-4b19-8eec-2e30b0950f01" source="mpk1_mpk1_s1051_mpk1_mpk1_csa103" target="pr_08ace191-fcf5-4f26-aeeb-64ed25349fc1"> <start x="1768.9965" y="2911.5"/> <next x="2226.4646" y="2905.6943"/> <end x="2241.0542" y="2622.446"/> </arc> <arc class="catalysis" id="modif_514240f5-264f-4a59-82fb-39bb29ebf003" source="mpk1_mpk1_s1050_mpk1_mpk1_csa105" target="pr_08ace191-fcf5-4f26-aeeb-64ed25349fc1"> <start x="1808.9965" y="3110.0"/> <next x="2230.4026" y="3111.2024"/> <end x="2241.0542" y="2622.446"/> </arc> <arc class="consumption" id="cons_25ed8c83-d610-4bb0-aea7-e37da4e2dbc0" source="mpk1_mpk1_s677_mpk1_mpk1_sa399" target="pr_8463a6cb-6bef-43f3-9404-699dc297e124_p1"> <start x="2925.6328" y="2606.75"/> <end x="3026.3145" y="2606.25"/> </arc> <arc class="production" id="prod_6379ef0d-203e-46c6-a3e9-07430a6732a4" source="pr_8463a6cb-6bef-43f3-9404-699dc297e124_p2" target="mpk1_mpk1_s676_mpk1_mpk1_sa398"> <start x="3056.3145" y="2606.25"/> <end x="3156.9963" y="2605.75"/> </arc> <arc class="catalysis" id="modif_de6ee1ab-02fc-4d9c-a554-8ae67e59fb9b" source="mpk1_mpk1_s689_mpk1_mpk1_sa413" target="pr_8463a6cb-6bef-43f3-9404-699dc297e124"> <start x="3690.663" y="2803.0"/> <next x="3692.9624" y="2739.8528"/> <next x="3045.1897" y="2742.3584"/> <end x="3041.3362" y="2611.25"/> </arc> <arc class="consumption" id="cons_97d240b2-528b-402b-b03e-eb4cfed4f443" source="mpk1_mpk1_s1033_mpk1_mpk1_csa61" target="pr_dd980677-8218-495b-82da-e89b54a13d96_p1"> <start x="1691.0" y="2144.0"/> <end x="1790.5939" y="2233.5"/> </arc> <arc class="production" id="prod_56750305-6f36-4088-bc08-13aafe6e566c" source="pr_dd980677-8218-495b-82da-e89b54a13d96_p2" target="mpk1_mpk1_s1030_mpk1_mpk1_csa27"> <start x="1790.5939" y="2263.5"/> <next x="1890.1877" y="2353.0"/> <next x="1891.974" y="2213.4478"/> <next x="1791.1366" y="2212.6646"/> <end x="1799.0" y="1946.0"/> </arc> <arc class="production" id="prod_3a0dedd2-1da9-41ff-bf66-e87632848724" source="pr_dd980677-8218-495b-82da-e89b54a13d96_p2" target="mpk1_mpk1_s174_mpk1_mpk1_sa64"> <start x="1790.5939" y="2263.5"/> <next x="1890.1877" y="2353.0"/> <next x="1893.3041" y="2563.685"/> <next x="2128.0393" y="2563.6755"/> <end x="2127.5" y="2592.0"/> </arc> <arc class="catalysis" id="modif_0ce86800-3ccc-4b91-89c0-e9c40ef5d1ff" source="mpk1_mpk1_s800_mpk1_mpk1_sa555" target="pr_dd980677-8218-495b-82da-e89b54a13d96"> <start x="2109.0" y="2400.0"/> <next x="2122.735" y="2243.4285"/> <end x="1794.2134" y="2245.0505"/> </arc> <arc class="catalysis" id="modif_ddc644ed-322f-47ca-aba4-95cd1c62292b" source="mpk1_mpk1_s675_mpk1_mpk1_sa397" target="pr_dd980677-8218-495b-82da-e89b54a13d96"> <start x="3620.6328" y="2645.0"/> <next x="3627.9893" y="2873.521"/> <next x="1792.3534" y="2871.9944"/> <end x="1790.424" y="2255.569"/> </arc> <arc class="catalysis" id="modif_4f01d227-0f66-49c3-92ce-3c41244dbf6b" source="mpk1_mpk1_s1052_mpk1_mpk1_csa104" target="pr_dd980677-8218-495b-82da-e89b54a13d96"> <start x="1622.9965" y="3012.0"/> <next x="1789.7483" y="3010.4011"/> <end x="1790.424" y="2255.569"/> </arc> <arc class="catalysis" id="modif_cafe993d-493a-49af-99f5-b2ccebc05ae2" source="mpk1_mpk1_s1051_mpk1_mpk1_csa103" target="pr_dd980677-8218-495b-82da-e89b54a13d96"> <start x="1768.9965" y="2926.0"/> <next x="1780.9855" y="2926.058"/> <end x="1790.424" y="2255.569"/> </arc> <arc class="catalysis" id="modif_09c9dadc-823f-4cb7-9b08-9b02b189cc63" source="mpk1_mpk1_s1050_mpk1_mpk1_csa105" target="pr_dd980677-8218-495b-82da-e89b54a13d96"> <start x="1783.7465" y="3068.0"/> <end x="1790.424" y="2255.569"/> </arc> <arc class="consumption" id="cons_0b0be0f3-df85-40d1-9e42-337fdf9cc9b4" source="mpk1_mpk1_s799_mpk1_mpk1_sa554" target="pr_55ef6a66-a47f-47d2-9d2d-b696bc7622b8_p1"> <start x="1997.4404" y="2663.1904"/> <end x="1997.4702" y="2617.8452"/> </arc> <arc class="production" id="prod_223bd7d2-4520-4b96-8469-e0757ebed17b" source="pr_55ef6a66-a47f-47d2-9d2d-b696bc7622b8_p2" target="mpk1_mpk1_s327_mpk1_mpk1_sa264"> <start x="1997.4702" y="2587.8452"/> <end x="1997.5" y="2542.5"/> </arc> <arc class="catalysis" id="modif_d9d7c38e-7ccb-4fce-bd99-d37eba883c86" source="mpk1_mpk1_s800_mpk1_mpk1_sa555" target="pr_55ef6a66-a47f-47d2-9d2d-b696bc7622b8"> <start x="2096.5" y="2425.0"/> <end x="2002.4727" y="2597.8477"/> </arc> <arc class="consumption" id="cons_dbbb9beb-b3da-4f09-93f5-f5d8fe7f09bb" source="mpk1_mpk1_s1005_mpk1_mpk1_csa43" target="pr_88748569-6f64-48ab-a0bc-21655fe13129_p1"> <start x="803.0" y="2458.25"/> <end x="1221.5" y="2479.5967"/> </arc> <arc class="production" id="prod_d839a118-7ce9-498d-9655-ff0236785718" source="pr_88748569-6f64-48ab-a0bc-21655fe13129_p2" target="mpk1_mpk1_s1007_mpk1_mpk1_csa58"> <start x="1251.5" y="2479.5967"/> <next x="1670.0" y="2500.9436"/> <next x="1668.2781" y="2187.251"/> <end x="737.0" y="2180.25"/> </arc> <arc class="production" id="prod_0ce13030-3c46-4175-ada9-51e832c69e1a" source="pr_88748569-6f64-48ab-a0bc-21655fe13129_p2" target="mpk1_mpk1_s174_mpk1_mpk1_sa64"> <start x="1251.5" y="2479.5967"/> <next x="1670.0" y="2500.9436"/> <next x="1873.2551" y="2503.5498"/> <next x="1878.2638" y="2616.939"/> <end x="2115.0" y="2610.75"/> </arc> <arc class="catalysis" id="modif_4ef2241f-550c-4a0e-a90c-feaa0f142871" source="mpk1_mpk1_s800_mpk1_mpk1_sa555" target="pr_88748569-6f64-48ab-a0bc-21655fe13129"> <start x="2084.0" y="2425.0"/> <next x="2080.0977" y="2482.3926"/> <end x="1241.7399" y="2474.8486"/> </arc> <arc class="catalysis" id="modif_c21a080b-a791-44e5-8dd7-d06fc725b7ef" source="mpk1_mpk1_s675_mpk1_mpk1_sa397" target="pr_88748569-6f64-48ab-a0bc-21655fe13129"> <start x="3620.6328" y="2645.0"/> <next x="3619.1096" y="2859.18"/> <next x="1211.7731" y="2860.0144"/> <end x="1241.248" y="2484.8364"/> </arc> <arc class="catalysis" id="modif_91f0b5e5-9cb8-45f2-9398-f79e9631d3ed" source="mpk1_mpk1_s1052_mpk1_mpk1_csa104" target="pr_88748569-6f64-48ab-a0bc-21655fe13129"> <start x="1514.9965" y="3012.0"/> <next x="1197.7014" y="3009.6138"/> <end x="1236.254" y="2484.5906"/> </arc> <arc class="catalysis" id="modif_7a669185-edf7-4287-bf95-f46281cdc7b8" source="mpk1_mpk1_s1051_mpk1_mpk1_csa103" target="pr_88748569-6f64-48ab-a0bc-21655fe13129"> <start x="1665.9965" y="2926.0"/> <next x="1202.5236" y="2930.6982"/> <end x="1236.254" y="2484.5906"/> </arc> <arc class="catalysis" id="modif_e407b4e8-602c-4c5e-b36b-3aa2af0fdf06" source="mpk1_mpk1_s1050_mpk1_mpk1_csa105" target="pr_88748569-6f64-48ab-a0bc-21655fe13129"> <start x="1707.9965" y="3110.0"/> <next x="1192.9916" y="3104.7793"/> <end x="1236.254" y="2484.5906"/> </arc> <arc class="consumption" id="cons_c6828d49-2819-414a-a0b3-8f8cf8edabc3" source="mpk1_mpk1_s984_mpk1_mpk1_csa66" target="pr_08a83097-3e0e-4650-8835-728c3a1d0ba3_p1"> <start x="2335.5" y="2122.0"/> <end x="2296.8203" y="2094.5"/> </arc> <arc class="production" id="prod_6568edc7-aeae-41c8-9f81-a38ef10b7fa3" source="pr_08a83097-3e0e-4650-8835-728c3a1d0ba3_p2" target="mpk1_mpk1_s978_mpk1_mpk1_csa60"> <start x="2296.8203" y="2064.5"/> <next x="2258.1404" y="2037.0"/> <next x="2683.3901" y="2029.9585"/> <end x="2683.0" y="2000.0"/> </arc> <arc class="production" id="prod_8e92014f-5809-4779-81f6-11b44ec84a5d" source="pr_08a83097-3e0e-4650-8835-728c3a1d0ba3_p2" target="mpk1_mpk1_s174_mpk1_mpk1_sa64"> <start x="2296.8203" y="2064.5"/> <next x="2258.1404" y="2037.0"/> <next x="2264.2683" y="2569.466"/> <next x="2165.2732" y="2568.7253"/> <end x="2165.0" y="2592.0"/> </arc> <arc class="catalysis" id="modif_b26b5638-e226-40f2-830e-27e2f83c7225" source="mpk1_mpk1_s800_mpk1_mpk1_sa555" target="pr_08a83097-3e0e-4650-8835-728c3a1d0ba3"> <start x="2134.0" y="2412.5"/> <next x="2278.6663" y="2420.0146"/> <end x="2293.1226" y="2082.8655"/> </arc> <arc class="catalysis" id="modif_5fca1679-04a5-41d7-98e5-21abcf20837b" source="mpk1_mpk1_s675_mpk1_mpk1_sa397" target="pr_08a83097-3e0e-4650-8835-728c3a1d0ba3"> <start x="3620.6328" y="2645.0"/> <next x="3631.0042" y="2869.343"/> <next x="2282.9785" y="2870.811"/> <end x="2293.1226" y="2082.8655"/> </arc> <arc class="catalysis" id="modif_6ea31917-f4c5-4ccb-9c83-e4283b8e560f" source="mpk1_mpk1_s1052_mpk1_mpk1_csa104" target="pr_08a83097-3e0e-4650-8835-728c3a1d0ba3"> <start x="1622.9965" y="2990.0"/> <next x="2283.059" y="2984.863"/> <end x="2296.488" y="2086.5632"/> </arc> <arc class="catalysis" id="modif_98c00d9d-75c2-44b0-9e8e-5769ee19aa1f" source="mpk1_mpk1_s1051_mpk1_mpk1_csa103" target="pr_08a83097-3e0e-4650-8835-728c3a1d0ba3"> <start x="1717.4965" y="2897.0"/> <next x="1719.0363" y="2881.52"/> <next x="2362.591" y="2880.7336"/> <next x="2366.7847" y="2284.2812"/> <next x="2461.581" y="2281.5383"/> <next x="2457.8823" y="2079.0352"/> <end x="2303.8835" y="2079.8323"/> </arc> <arc class="catalysis" id="modif_ff12fb68-de1c-403e-b60c-b848222ba5d3" source="mpk1_mpk1_s1050_mpk1_mpk1_csa105" target="pr_08a83097-3e0e-4650-8835-728c3a1d0ba3"> <start x="1808.9965" y="3089.0"/> <next x="2285.8894" y="3090.962"/> <end x="2296.488" y="2086.5632"/> </arc> <arc class="consumption" id="cons_40dfdeb2-6efe-47ba-a046-7c9c682080f7" source="mpk1_mpk1_s1015_mpk1_mpk1_csa19" target="pr_6d4ad592-5f40-435d-a117-9ae10ef2dd1f_p1"> <start x="1489.25" y="2532.5"/> <next x="1466.7855" y="2511.1025"/> <end x="1616.8928" y="2512.7065"/> </arc> <arc class="production" id="prod_07ee035d-39d5-4542-90de-834acb31b4b9" source="pr_6d4ad592-5f40-435d-a117-9ae10ef2dd1f_p2" target="mpk1_mpk1_s1013_mpk1_mpk1_csa16"> <start x="1646.8928" y="2512.7065"/> <next x="1797.0" y="2514.3108"/> <next x="1803.7367" y="2370.118"/> <end x="1182.0" y="2362.0"/> </arc> <arc class="production" id="prod_b3038d82-5262-496f-b778-d44a54fc96f0" source="pr_6d4ad592-5f40-435d-a117-9ae10ef2dd1f_p2" target="mpk1_mpk1_s174_mpk1_mpk1_sa64"> <start x="1646.8928" y="2512.7065"/> <next x="1797.0" y="2514.3108"/> <next x="1802.4868" y="2602.3489"/> <end x="2115.0" y="2598.25"/> </arc> <arc class="catalysis" id="modif_b3fcb7fb-436b-4260-92db-0197eeccb832" source="mpk1_mpk1_s800_mpk1_mpk1_sa555" target="pr_6d4ad592-5f40-435d-a117-9ae10ef2dd1f"> <start x="2121.5" y="2425.0"/> <next x="2134.1611" y="2443.6611"/> <next x="1618.7759" y="2441.6624"/> <end x="1626.9417" y="2507.6582"/> </arc> <arc class="catalysis" id="modif_95ea5a62-57c1-4194-a02e-6e4ba1a5f0a5" source="mpk1_mpk1_s675_mpk1_mpk1_sa397" target="pr_6d4ad592-5f40-435d-a117-9ae10ef2dd1f"> <start x="3620.6328" y="2638.75"/> <next x="3623.14" y="2864.9744"/> <next x="1641.3391" y="2867.7927"/> <end x="1631.8442" y="2517.7063"/> </arc> <arc class="catalysis" id="modif_51d0bbc6-6459-4814-b4b1-187dee323ee9" source="mpk1_mpk1_s1052_mpk1_mpk1_csa104" target="pr_6d4ad592-5f40-435d-a117-9ae10ef2dd1f"> <start x="1595.9965" y="2968.0"/> <end x="1626.8445" y="2517.6577"/> </arc> <arc class="catalysis" id="modif_3a74218f-e3cf-4b7a-9cc6-9dabed9ee0e4" source="mpk1_mpk1_s1051_mpk1_mpk1_csa103" target="pr_6d4ad592-5f40-435d-a117-9ae10ef2dd1f"> <start x="1665.9965" y="2897.0"/> <end x="1631.8442" y="2517.7063"/> </arc> <arc class="catalysis" id="modif_92cb371c-2bba-48db-a6e1-5f8ada27e672" source="mpk1_mpk1_s1050_mpk1_mpk1_csa105" target="pr_6d4ad592-5f40-435d-a117-9ae10ef2dd1f"> <start x="1707.9965" y="3089.0"/> <next x="1636.0653" y="3090.3206"/> <end x="1631.8442" y="2517.7063"/> </arc> <arc class="production" id="addprod_a5ebe9cc-44e2-4c5c-9c29-91dfeb29c531" source="pr_6d4ad592-5f40-435d-a117-9ae10ef2dd1f_p2" target="mpk1_mpk1_s358_mpk1_mpk1_sa240"> <start x="1646.8928" y="2512.7065"/> <end x="843.0" y="2215.0"/> </arc> <arc class="consumption" id="cons_2541e546-8859-4d08-9d77-e48b04e4be67" source="mpk1_mpk1_s801_mpk1_mpk1_sa556" target="pr_7977c20b-b94f-430f-97e7-cd55dfe2cf0a_p1"> <start x="2198.5" y="2372.6665"/> <end x="2181.25" y="2386.3333"/> </arc> <arc class="production" id="prod_935104f7-05e5-4ee4-a302-d7a4a1c3f210" source="pr_7977c20b-b94f-430f-97e7-cd55dfe2cf0a_p2" target="mpk1_mpk1_s800_mpk1_mpk1_sa555"> <start x="2151.25" y="2386.3333"/> <end x="2134.0" y="2400.0"/> </arc> <arc class="catalysis" id="modif_d6acdc3f-a5f8-48be-9d1f-266c11a03896" source="mpk1_mpk1_s675_mpk1_mpk1_sa397" target="pr_7977c20b-b94f-430f-97e7-cd55dfe2cf0a"> <start x="3570.6328" y="2632.5"/> <next x="2838.782" y="2640.2642"/> <next x="2837.4514" y="2444.5286"/> <next x="2299.2666" y="2443.2861"/> <next x="2298.232" y="2393.006"/> <end x="2168.201" y="2390.937"/> </arc> <arc class="consumption" id="cons_75d3ed40-92cd-46b9-91b4-96f9931b50d2" source="mpk1_mpk1_s563_mpk1_mpk1_sa330" target="pr_0220a191-25d0-4a58-b658-af352a7084d0_p1"> <start x="524.8334" y="3154.0"/> <end x="523.78815" y="3205.8713"/> </arc> <arc class="production" id="prod_bc5283da-e0f1-46ba-a3a1-6d16094d8412" source="pr_0220a191-25d0-4a58-b658-af352a7084d0_p2" target="mpk1_mpk1_s894_mpk1_mpk1_sa652"> <start x="523.78815" y="3235.8713"/> <next x="522.7429" y="3287.7427"/> <end x="286.0" y="3287.0"/> </arc> <arc class="consumption" id="cons_73696016-538d-4642-890d-53e1c6330f14" source="mpk1_mpk1_s563_mpk1_mpk1_sa330" target="pr_64dfe150-c5f2-4556-9284-7b490af1cb77_p1"> <start x="524.8334" y="3154.0"/> <end x="524.29846" y="3205.8071"/> </arc> <arc class="production" id="prod_ebcf7d4c-afab-422f-8058-d593421acd7f" source="pr_64dfe150-c5f2-4556-9284-7b490af1cb77_p2" target="mpk1_mpk1_s896_mpk1_mpk1_sa654"> <start x="524.29846" y="3235.8071"/> <next x="523.76355" y="3287.6143"/> <next x="612.98126" y="3289.041"/> <end x="613.0" y="3328.5"/> </arc> <arc class="consumption" id="cons_4626977f-8aef-47d5-924a-7b75e7909b30" source="mpk1_mpk1_s563_mpk1_mpk1_sa330" target="pr_62bc7a63-b1d7-40bf-9379-82e0c29b7769_p1"> <start x="524.8334" y="3154.0"/> <end x="523.69684" y="3205.621"/> </arc> <arc class="production" id="prod_effdac31-7e1d-4bf6-8e4c-e6d66c7f7e80" source="pr_62bc7a63-b1d7-40bf-9379-82e0c29b7769_p2" target="mpk1_mpk1_s895_mpk1_mpk1_sa653"> <start x="523.69684" y="3235.621"/> <next x="522.5603" y="3287.2422"/> <end x="1051.0" y="3291.0"/> </arc> <arc class="consumption" id="cons_2a8c1e8b-1e98-410d-b7dc-92ef25f151f5" source="mpk1_mpk1_s563_mpk1_mpk1_sa330" target="pr_584789cc-c021-4fad-adf9-eec0a99f6799_p1"> <start x="524.8334" y="3154.0"/> <end x="523.8235" y="3205.3984"/> </arc> <arc class="production" id="prod_03524d64-35b9-44c4-bd7f-292fe708d5ac" source="pr_584789cc-c021-4fad-adf9-eec0a99f6799_p2" target="mpk1_mpk1_s898_mpk1_mpk1_sa656"> <start x="523.8235" y="3235.3984"/> <next x="522.8136" y="3286.797"/> <next x="495.08173" y="3288.3875"/> <end x="495.0" y="3328.5"/> </arc> <arc class="consumption" id="cons_d4645adc-0ba5-415f-b91f-78f31634135a" source="mpk1_mpk1_s563_mpk1_mpk1_sa330" target="pr_4847a669-2f38-4a5e-80fb-7a81261f0d90_p1"> <start x="524.8334" y="3154.0"/> <end x="523.53687" y="3205.6372"/> </arc> <arc class="production" id="prod_39d3716a-999f-46a0-902c-5ce58797bd8c" source="pr_4847a669-2f38-4a5e-80fb-7a81261f0d90_p2" target="mpk1_mpk1_s897_mpk1_mpk1_sa655"> <start x="523.53687" y="3235.6372"/> <next x="522.2404" y="3287.2742"/> <next x="851.0239" y="3289.3237"/> <next x="851.01776" y="3311.8936"/> <end x="2328.0" y="3313.0"/> </arc> <arc class="consumption" id="cons_9db838e1-26c4-436f-9021-5b1cce097133" source="mpk1_mpk1_s787_mpk1_mpk1_sa544" target="pr_134dba57-7387-4556-a607-7ad229e01257_p1"> <start x="3370.7144" y="3104.8572"/> <end x="3369.9927" y="3173.2764"/> </arc> <arc class="production" id="prod_92b24359-e864-4b5f-981a-8bd184d8c034" source="pr_134dba57-7387-4556-a607-7ad229e01257_p2" target="mpk1_mpk1_s899_mpk1_mpk1_sa657"> <start x="3369.9927" y="3203.2764"/> <next x="3369.2712" y="3271.6956"/> <next x="3595.0264" y="3270.8232"/> <end x="3596.0" y="3305.5"/> </arc> <arc class="consumption" id="cons_3d6e1289-0649-4a73-b803-48a2fc497241" source="mpk1_mpk1_s787_mpk1_mpk1_sa544" target="pr_42470d2f-ca19-4c9f-8bdd-f9c45449747e_p1"> <start x="3370.7144" y="3104.8572"/> <end x="3369.685" y="3172.9062"/> </arc> <arc class="production" id="prod_9a5a7d48-3d42-464e-b32a-8db1978af060" source="pr_42470d2f-ca19-4c9f-8bdd-f9c45449747e_p2" target="mpk1_mpk1_s900_mpk1_mpk1_sa658"> <start x="3369.685" y="3202.9062"/> <next x="3368.6558" y="3270.955"/> <next x="3345.7979" y="3272.3923"/> <end x="3345.0" y="3301.5"/> </arc> <arc class="consumption" id="cons_9102f525-4ef2-40c3-81f7-7039f1f1e223" source="mpk1_mpk1_s787_mpk1_mpk1_sa544" target="pr_e55c1ed4-1347-46ff-8fcc-0ed74b811415_p1"> <start x="3370.7144" y="3104.8572"/> <end x="3370.1777" y="3173.1506"/> </arc> <arc class="production" id="prod_909f93d3-12aa-49a9-97c8-6c13e78ca883" source="pr_e55c1ed4-1347-46ff-8fcc-0ed74b811415_p2" target="mpk1_mpk1_s902_mpk1_mpk1_sa660"> <start x="3370.1777" y="3203.1506"/> <next x="3369.6414" y="3271.444"/> <next x="3437.582" y="3271.8914"/> <end x="3438.0" y="3303.5"/> </arc> <arc class="consumption" id="cons_e0b0e81b-d093-4280-abdd-93d4b9315cc0" source="mpk1_mpk1_s787_mpk1_mpk1_sa544" target="pr_ef378d8a-1d6e-42ac-a9d8-53e5c8134c42_p1"> <start x="3358.2144" y="3104.8572"/> <end x="3358.1072" y="3122.4287"/> </arc> <arc class="production" id="prod_7a50e340-dfd7-4b46-a204-d717177285df" source="pr_ef378d8a-1d6e-42ac-a9d8-53e5c8134c42_p2" target="mpk1_mpk1_s901_mpk1_mpk1_sa659"> <start x="3358.1072" y="3152.4287"/> <next x="3358.0" y="3170.0"/> <next x="3272.0" y="3170.0"/> <end x="3271.5" y="3302.5"/> </arc> <arc class="inhibition" id="modif_cc9e4ace-fdbf-427e-aeec-d4792c14e838" source="mpk1_mpk1_s926_mpk1_mpk1_sa681" target="pr_ef378d8a-1d6e-42ac-a9d8-53e5c8134c42"> <start x="3065.0" y="3150.0"/> <next x="3210.5544" y="3150.0002"/> <next x="3210.5547" y="3137.412"/> <end x="3353.1072" y="3137.4124"/> </arc> <arc class="consumption" id="cons_2cfe5e44-4fff-442a-ad3f-f1f97291c85c" source="mpk1_mpk1_s787_mpk1_mpk1_sa544" target="pr_bd6be792-25b7-48b9-bff8-47113ff5fb61_p1"> <start x="3370.7144" y="3104.8572"/> <end x="3370.0552" y="3173.1108"/> </arc> <arc class="production" id="prod_12fe0552-ec2d-482c-a2fd-fffbf4287051" source="pr_bd6be792-25b7-48b9-bff8-47113ff5fb61_p2" target="mpk1_mpk1_s903_mpk1_mpk1_sa661"> <start x="3370.0552" y="3203.1108"/> <next x="3369.3958" y="3271.3647"/> <next x="3164.0237" y="3274.1606"/> <end x="3164.0" y="3301.5"/> </arc> <arc class="consumption" id="cons_8cef5ac4-0d15-46cd-bdb0-f4484f498480" source="mpk1_mpk1_s787_mpk1_mpk1_sa544" target="pr_915325a5-01be-40a9-a4f0-68b897b55699_p1"> <start x="3370.7144" y="3104.8572"/> <end x="3369.4858" y="3173.1323"/> </arc> <arc class="production" id="prod_39089c47-74cc-40f2-bbd4-db8445d2a3e7" source="pr_915325a5-01be-40a9-a4f0-68b897b55699_p2" target="mpk1_mpk1_s904_mpk1_mpk1_sa662"> <start x="3369.4858" y="3203.1323"/> <next x="3368.2576" y="3271.4075"/> <next x="3056.9656" y="3274.6565"/> <end x="3058.0" y="3302.5"/> </arc> <arc class="consumption" id="cons_a6118a7d-2884-4a24-961f-3e52ccf2bc59" source="mpk1_mpk1_s377_mpk1_mpk1_sa251" target="pr_bb6dd601-83cc-4c40-a8f7-a9e9fb7921ce_p1"> <start x="1403.0" y="3091.0"/> <end x="1402.7256" y="3175.829"/> </arc> <arc class="production" id="prod_7414ae33-5041-4ef1-8283-47a480bbd495" source="pr_bb6dd601-83cc-4c40-a8f7-a9e9fb7921ce_p2" target="mpk1_mpk1_s895_mpk1_mpk1_sa653"> <start x="1402.7256" y="3205.829"/> <next x="1402.451" y="3290.658"/> <end x="1121.0" y="3291.0"/> </arc> <arc class="consumption" id="cons_b5d18d4a-422b-482c-ba53-28d055bed45c" source="mpk1_mpk1_s575_mpk1_mpk1_sa340" target="pr_0129b9e1-3c60-4d02-b171-7a4cfd9a0fbd_p1"> <start x="1282.0" y="1958.0"/> <next x="433.05676" y="1959.9985"/> <next x="429.73572" y="2064.1084"/> <next x="87.29923" y="2064.871"/> <end x="85.75599" y="2803.0413"/> </arc> <arc class="production" id="prod_a0f42373-c1d0-439d-b92d-d0cf24e85806" source="pr_0129b9e1-3c60-4d02-b171-7a4cfd9a0fbd_p2" target="mpk1_mpk1_s910_mpk1_mpk1_sa668"> <start x="85.75599" y="2833.0413"/> <next x="84.212746" y="3571.2114"/> <next x="1046.9784" y="3571.0435"/> <end x="1040.0" y="3488.5"/> </arc> <arc class="consumption" id="cons_15ca5dab-c061-482e-a2b9-c25de740bc6b" source="mpk1_mpk1_s894_mpk1_mpk1_sa652" target="pr_a2297de9-004a-4ad4-b356-90130f300289_p1"> <start x="216.0" y="3287.0"/> <next x="78.196655" y="3287.9756"/> <end x="78.85504" y="2694.448"/> </arc> <arc class="production" id="prod_e041dd10-0950-4101-994a-c6ee0dc29dfb" source="pr_a2297de9-004a-4ad4-b356-90130f300289_p2" target="mpk1_mpk1_s574_mpk1_mpk1_sa339"> <start x="78.85504" y="2664.448"/> <next x="79.51343" y="2070.9204"/> <next x="436.2594" y="2071.0398"/> <next x="436.96295" y="1970.4829"/> <end x="1132.0" y="1980.75"/> </arc> <arc class="consumption" id="cons_dfd78cad-cd2b-42d1-bd57-558fb103ad19" source="mpk1_mpk1_s895_mpk1_mpk1_sa653" target="pr_52aadc53-483d-4240-ad10-ac273f6fb796_p1"> <start x="1086.0" y="3278.5"/> <end x="1085.754" y="3100.232"/> </arc> <arc class="production" id="prod_3e987a87-096e-4715-9827-126fa3502558" source="pr_52aadc53-483d-4240-ad10-ac273f6fb796_p2" target="mpk1_mpk1_s379_mpk1_mpk1_sa254"> <start x="1085.754" y="3070.232"/> <next x="1085.508" y="2891.9636"/> <end x="1126.0" y="2893.5"/> </arc> <arc class="consumption" id="cons_12c05747-d0d7-4c0b-8489-bbca52e01689" source="mpk1_mpk1_s899_mpk1_mpk1_sa657" target="pr_28581313-4736-4681-9927-3c0b0671d6b2_p1"> <start x="3613.5" y="3330.5"/> <next x="3612.4583" y="3569.9785"/> <next x="4266.9336" y="3569.8804"/> <end x="4268.467" y="3074.9402"/> </arc> <arc class="production" id="prod_1957c226-43ad-4a46-a90a-c0707ecf8449" source="pr_28581313-4736-4681-9927-3c0b0671d6b2_p2" target="mpk1_mpk1_s670_mpk1_mpk1_sa384"> <start x="4268.467" y="3044.9402"/> <next x="4270.0" y="2550.0"/> <next x="4110.0" y="2550.0"/> <end x="4108.75" y="2577.5"/> </arc> <arc class="consumption" id="cons_4041f4a3-0a59-4c1c-9046-fd0080812f9d" source="mpk1_mpk1_s787_mpk1_mpk1_sa544" target="pr_196dd1d4-a66e-45dc-8074-f86791927957_p1"> <start x="3383.2144" y="3079.8572"/> <end x="3380.8572" y="3017.4287"/> </arc> <arc class="production" id="prod_858ccbe6-c0b7-410c-be1c-59230ff41ef4" source="pr_196dd1d4-a66e-45dc-8074-f86791927957_p2" target="mpk1_mpk1_s786_mpk1_mpk1_sa543"> <start x="3380.8572" y="2987.4287"/> <end x="3378.5" y="2925.0"/> </arc> <arc class="catalysis" id="modif_79017406-6446-481e-8bb0-60fac2463b50" source="mpk1_mpk1_s924_mpk1_mpk1_sa679" target="pr_196dd1d4-a66e-45dc-8074-f86791927957"> <start x="3265.0" y="3060.0"/> <end x="3376.0117" y="3007.5786"/> </arc> <arc class="consumption" id="cons_59823de5-0624-4452-99a8-3a4b36973e2d" source="mpk1_mpk1_s897_mpk1_mpk1_sa655" target="pr_08eb4d2d-86ce-4a9b-b252-efb20fb53c57_p1"> <start x="2398.0" y="3313.0"/> <end x="2529.463" y="3312.4739"/> </arc> <arc class="production" id="prod_5b93315f-cc21-47dc-a944-6abb3b48fa93" source="pr_08eb4d2d-86ce-4a9b-b252-efb20fb53c57_p2" target="mpk1_mpk1_s797_mpk1_mpk1_sa552"> <start x="2559.463" y="3312.4739"/> <next x="2690.926" y="3311.9478"/> <end x="2686.7856" y="2900.1428"/> </arc> <arc class="consumption" id="cons_56f429e3-7879-4e55-a96a-9dfd9a3f7e2a" source="mpk1_mpk1_s183_mpk1_mpk1_sa278" target="pr_bb6eddc1-d5fa-4f89-b8e1-18b5b561073d_p1"> <start x="1908.0" y="2273.5"/> <next x="1758.4958" y="2272.1074"/> <next x="1759.6943" y="2163.0437"/> <next x="700.00183" y="2152.0"/> <next x="700.0019" y="1962.0002"/> <next x="431.2057" y="1958.9646"/> <next x="430.74557" y="2064.0986"/> <next x="86.640816" y="2064.3252"/> <end x="86.132866" y="2802.6309"/> </arc> <arc class="production" id="prod_ea97a049-3d0e-4efc-8a8d-549950a46d61" source="pr_bb6eddc1-d5fa-4f89-b8e1-18b5b561073d_p2" target="mpk1_mpk1_s910_mpk1_mpk1_sa668"> <start x="86.132866" y="2832.6309"/> <next x="85.624916" y="3570.9368"/> <next x="1045.9927" y="3571.904"/> <end x="1040.0" y="3488.5"/> </arc> <arc class="consumption" id="cons_02c1fddd-66d4-4158-9c29-2e6848f06579" source="mpk1_mpk1_s698_mpk1_mpk1_sa422" target="pr_84c1ee2f-7f43-4c6e-abc4-ecbb0dc042a1_p1"> <start x="3158.3298" y="3118.3335"/> <next x="3157.643" y="3183.5906"/> <next x="2776.0288" y="3183.0474"/> <end x="2774.0144" y="3306.7737"/> </arc> <arc class="production" id="prod_01f472f6-a807-4c10-8235-880f6341de28" source="pr_84c1ee2f-7f43-4c6e-abc4-ecbb0dc042a1_p2" target="mpk1_mpk1_s909_mpk1_mpk1_sa667"> <start x="2774.0144" y="3336.7737"/> <end x="2772.0" y="3460.5"/> </arc> <arc class="consumption" id="cons_ed7e72fc-279c-4ba1-a315-3b0bc23a00bf" source="mpk1_mpk1_s913_mpk1_mpk1_sa671" target="pr_dddf86e2-a133-439b-9420-5d9f05fd9251_p1"> <start x="4050.0" y="2662.5"/> <next x="4050.0" y="2681.25"/> <next x="4050.0" y="2681.25"/> <next x="4050.0" y="2740.0"/> <end x="4050.0" y="2792.0"/> </arc> <arc class="consumption" id="cons_7b37ccd6-1003-4a12-81bf-85f291700ae0" source="mpk1_mpk1_s921_mpk1_mpk1_sa677" target="pr_dddf86e2-a133-439b-9420-5d9f05fd9251_p1"> <start x="4155.0" y="2740.0"/> <next x="4102.5" y="2740.0"/> <next x="4102.5" y="2740.0"/> <next x="4050.0" y="2740.0"/> <end x="4050.0" y="2792.0"/> </arc> <arc class="production" id="prod_3191e8e8-80de-4fce-b7aa-8de975268073" source="pr_dddf86e2-a133-439b-9420-5d9f05fd9251_p2" target="mpk1_mpk1_s1028_mpk1_mpk1_csa108"> <start x="4050.0" y="2822.0"/> <next x="4050.0" y="2870.0"/> <next x="3660.0" y="2870.0"/> <end x="3660.0" y="2950.0"/> </arc> <arc class="catalysis" id="modif_adbd1bef-5055-4b6d-a5b9-0b1148aaeca0" source="mpk1_mpk1_s49_mpk1_mpk1_csa80" target="pr_dddf86e2-a133-439b-9420-5d9f05fd9251"> <start x="3549.9963" y="1330.0"/> <next x="4291.74" y="1330.7607"/> <next x="4290.226" y="2807.2412"/> <end x="4055.0" y="2807.0"/> </arc> <arc class="consumption" id="cons_95e664af-f793-4f3e-b612-fe3ce31bfc62" source="mpk1_mpk1_s914_mpk1_mpk1_sa672" target="pr_d78ef261-5c3b-4248-8ecf-5b134d092184_p1"> <start x="4130.0" y="2662.5"/> <next x="4130.0" y="2667.5"/> <next x="4130.0" y="2667.5"/> <next x="4130.0" y="2690.0"/> <end x="4130.0" y="2782.0"/> </arc> <arc class="consumption" id="cons_cb554411-f172-4b7f-8c47-462acd874d7b" source="mpk1_mpk1_s921_mpk1_mpk1_sa677" target="pr_d78ef261-5c3b-4248-8ecf-5b134d092184_p1"> <start x="4180.0" y="2727.5"/> <next x="4180.0" y="2690.0"/> <next x="4130.0" y="2690.0"/> <end x="4130.0" y="2782.0"/> </arc> <arc class="production" id="prod_0d7afa28-9006-4349-85a0-99a4bf31a00b" source="pr_d78ef261-5c3b-4248-8ecf-5b134d092184_p2" target="mpk1_mpk1_s1027_mpk1_mpk1_csa109"> <start x="4130.0" y="2812.0"/> <next x="4130.0" y="2900.0"/> <next x="3780.0" y="2900.0"/> <end x="3780.0" y="2950.0"/> </arc> <arc class="catalysis" id="modif_84cb7003-a58c-45be-95eb-1a132a9d511d" source="mpk1_mpk1_s49_mpk1_mpk1_csa80" target="pr_d78ef261-5c3b-4248-8ecf-5b134d092184"> <start x="3549.9963" y="1362.0"/> <next x="4281.6904" y="1362.7972"/> <next x="4280.128" y="2797.1582"/> <end x="4135.0" y="2797.0"/> </arc> <arc class="consumption" id="cons_3d47a035-0519-4acf-9abe-bcedf1fc2e40" source="mpk1_mpk1_s1028_mpk1_mpk1_csa108" target="pr_9b371664-78f8-4499-be9e-e36c8a573deb_p1"> <start x="3660.0" y="3030.0"/> <next x="3660.0" y="3168.75"/> <end x="3651.75" y="3168.75"/> </arc> <arc class="production" id="prod_9a17a31b-f8ba-4e1b-a2e2-71dbf123903b" source="pr_9b371664-78f8-4499-be9e-e36c8a573deb_p2" target="mpk1_mpk1_s899_mpk1_mpk1_sa657"> <start x="3621.75" y="3168.75"/> <next x="3613.5" y="3168.75"/> <end x="3613.5" y="3305.5"/> </arc> <arc class="consumption" id="cons_f88072f4-fa8d-403d-9d50-416a7174439f" source="mpk1_mpk1_s1027_mpk1_mpk1_csa109" target="pr_aeee12fa-f65c-4124-9ba0-bf5f68e2226e_p1"> <start x="3780.0" y="3030.0"/> <next x="3780.0" y="3168.75"/> <end x="3711.75" y="3168.75"/> </arc> <arc class="production" id="prod_28ec8699-6347-435e-80cd-67694a384b87" source="pr_aeee12fa-f65c-4124-9ba0-bf5f68e2226e_p2" target="mpk1_mpk1_s899_mpk1_mpk1_sa657"> <start x="3681.75" y="3168.75"/> <next x="3613.5" y="3168.75"/> <end x="3613.5" y="3305.5"/> </arc> <arc class="consumption" id="cons_50d49791-e6d4-4a0c-821c-3c82c5210421" source="mpk1_mpk1_s634_mpk1_mpk1_sa391" target="pr_1a939095-7138-4ca2-93a4-1a1cf053f5ad_p1"> <start x="4070.0" y="2252.0"/> <end x="4076.5" y="2284.75"/> </arc> <arc class="production" id="prod_33bcd610-8f22-44dd-9a82-233eca1c14cb" source="pr_1a939095-7138-4ca2-93a4-1a1cf053f5ad_p2" target="mpk1_mpk1_s635_mpk1_mpk1_sa530"> <start x="4076.5" y="2314.75"/> <end x="4083.0" y="2347.5"/> </arc> <arc class="catalysis" id="modif_2f30d35b-8411-48f3-8bf6-6ba10807fc33" source="mpk1_mpk1_s922_mpk1_mpk1_sa678" target="pr_1a939095-7138-4ca2-93a4-1a1cf053f5ad"> <start x="4190.0" y="2558.5"/> <next x="4189.991" y="2299.072"/> <end x="4081.4543" y="2299.0757"/> </arc> <arc class="consumption" id="cons_f4dfa5e6-7e52-44f5-9c5b-9863de0fd5cc" source="mpk1_mpk1_s901_mpk1_mpk1_sa659" target="pr_b3040e65-85a4-4dee-84c8-644554e3ab17_p1"> <start x="3236.5" y="3302.5"/> <end x="3238.25" y="3202.5"/> </arc> <arc class="production" id="prod_ab91d6dc-e734-408d-87d8-856020405684" source="pr_b3040e65-85a4-4dee-84c8-644554e3ab17_p2" target="mpk1_mpk1_s924_mpk1_mpk1_sa679"> <start x="3238.25" y="3172.5"/> <end x="3240.0" y="3072.5"/> </arc> <arc class="consumption" id="cons_a1b32560-d0a5-4158-9540-b59314ebbe7b" source="mpk1_mpk1_s696_mpk1_mpk1_sa420" target="pr_3ad4fb14-cbf9-4ed9-b539-05c835d08eee_p1"> <start x="3551.163" y="2975.3335"/> <next x="3551.163" y="3230.0002"/> <end x="3261.8315" y="3230.0"/> </arc> <arc class="production" id="prod_0ca25c7b-7281-433e-a203-de2f1fe5b489" source="pr_3ad4fb14-cbf9-4ed9-b539-05c835d08eee_p2" target="mpk1_mpk1_s925_mpk1_mpk1_sa680"> <start x="3231.8315" y="3230.0"/> <next x="2942.5" y="3230.0"/> <end x="2942.5" y="3301.5"/> </arc> <arc class="consumption" id="cons_753adc73-9d54-4429-a920-6673bd1239a8" source="mpk1_mpk1_s925_mpk1_mpk1_sa680" target="pr_7857762c-ca8f-42b6-b21e-b5afa672e905_p1"> <start x="2977.5" y="3301.5"/> <next x="2977.5" y="3200.0"/> <end x="2993.75" y="3200.0"/> </arc> <arc class="production" id="prod_7699591b-3b6d-4b03-8021-c895adc90f53" source="pr_7857762c-ca8f-42b6-b21e-b5afa672e905_p2" target="mpk1_mpk1_s926_mpk1_mpk1_sa681"> <start x="3023.75" y="3200.0"/> <next x="3040.0" y="3200.0"/> <end x="3040.0" y="3162.5"/> </arc> <arc class="consumption" id="cons_f915ff0d-873c-4f0f-be5e-fd4eb754b989" source="mpk1_mpk1_s927_mpk1_mpk1_sa682" target="pr_8bb6403c-b505-4d39-8be2-f00fc998bfb1_p1"> <start x="2860.0" y="3362.5"/> <next x="2860.0" y="3390.0"/> <end x="3184.3315" y="3390.0"/> </arc> <arc class="production" id="prod_e24ed7f5-18b3-4d34-99db-13c24cb4ecfb" source="pr_8bb6403c-b505-4d39-8be2-f00fc998bfb1_p2" target="mpk1_mpk1_s696_mpk1_mpk1_sa420"> <start x="3214.3315" y="3390.0"/> <next x="3538.663" y="3390.0"/> <end x="3538.663" y="2975.3335"/> </arc> <arc class="consumption" id="cons_4d102756-de12-4b2f-beba-8e572abbae29" source="mpk1_mpk1_s561_mpk1_mpk1_sa328" target="pr_3ff9adf9-75e1-4995-bac2-71548b48c102_p1"> <start x="547.1666" y="2977.1665"/> <next x="689.99994" y="2977.1665"/> <end x="689.99994" y="3148.583"/> </arc> <arc class="production" id="prod_0940e7a2-6a05-49e8-9f3f-4d9d4f46865e" source="pr_3ff9adf9-75e1-4995-bac2-71548b48c102_p2" target="mpk1_mpk1_s927_mpk1_mpk1_sa682"> <start x="689.99994" y="3178.583"/> <next x="689.99994" y="3349.9998"/> <end x="2825.0" y="3350.0"/> </arc> <arc class="consumption" id="cons_c7c22e87-811e-49df-a184-cecb9b7476d4" source="mpk1_mpk1_s928_mpk1_mpk1_sa683" target="pr_1d70829e-8e46-4909-b0f4-76cbe1b98e60_p1"> <start x="2540.0" y="2972.5"/> <next x="2540.0" y="3015.0"/> <end x="2540.0" y="3030.0"/> </arc> <arc class="production" id="prod_42961ded-2d13-4752-a3c0-ea4003ee97df" source="pr_1d70829e-8e46-4909-b0f4-76cbe1b98e60_p2" target="mpk1_mpk1_s929_mpk1_mpk1_sa684"> <start x="2540.0" y="3000.0"/> <next x="2540.0" y="3015.0"/> <end x="2540.0" y="3077.5"/> </arc> <arc class="catalysis" id="modif_a8ea1dd3-46c5-4c6e-a987-8d931ebf298e" source="mpk1_mpk1_s796_mpk1_mpk1_sa551" target="pr_1d70829e-8e46-4909-b0f4-76cbe1b98e60"> <start x="2398.5715" y="2906.6428"/> <end x="2540.0" y="3020.0"/> </arc> <arc class="consumption" id="cons_c9f33c18-c712-41a5-af23-5db76a7bec69" source="mpk1_mpk1_s930_mpk1_mpk1_sa685" target="pr_005c5f1b-22ef-4698-9480-e268151ad9a9_p1"> <start x="2630.0" y="2811.25"/> <next x="2630.0" y="3090.0"/> <end x="2628.75" y="3105.0"/> </arc> <arc class="production" id="prod_88e1a171-d7a1-4699-9b36-9e0361b06069" source="pr_005c5f1b-22ef-4698-9480-e268151ad9a9_p2" target="mpk1_mpk1_s931_mpk1_mpk1_sa686"> <start x="2628.75" y="3075.0"/> <next x="2627.5" y="3090.0"/> <end x="2627.5" y="3130.0"/> </arc> <arc class="catalysis" id="modif_5b71334d-3785-425d-a238-243f6cd1c7f4" source="mpk1_mpk1_s929_mpk1_mpk1_sa684" target="pr_005c5f1b-22ef-4698-9480-e268151ad9a9"> <start x="2565.0" y="3090.0"/> <end x="2623.75" y="3095.0"/> </arc> <arc class="inhibition" id="modif_a4a60ba5-59c6-4951-80f0-f3efd366f6ac" source="mpk1_mpk1_s950_mpk1_mpk1_sa700" target="pr_005c5f1b-22ef-4698-9480-e268151ad9a9"> <start x="635.0" y="2683.5"/> <next x="639.0573" y="2781.0347"/> <next x="729.09155" y="2780.9834"/> <next x="729.1316" y="2851.01"/> <next x="2649.8618" y="2849.9114"/> <next x="2649.9875" y="3069.9949"/> <end x="2633.75" y="3085.0"/> </arc> <arc class="consumption" id="cons_576d82cc-99f1-4fb7-9b22-37a5857da3f4" source="mpk1_mpk1_s932_mpk1_mpk1_sa687" target="pr_1bbb9807-f258-4609-8139-f12f2e3216b5_p1"> <start x="620.0" y="1807.5"/> <next x="620.0" y="1724.875"/> <next x="620.0" y="1724.875"/> <next x="620.0" y="1642.25"/> <end x="619.23193" y="1572.125"/> </arc> <arc class="consumption" id="cons_3fbf6b0c-9bc1-481d-a472-f04cfbf109ba" source="mpk1_mpk1_s278_mpk1_mpk1_sa169" target="pr_1bbb9807-f258-4609-8139-f12f2e3216b5_p1"> <start x="389.74875" y="1657.1611"/> <next x="389.74875" y="1642.25"/> <next x="620.0" y="1642.25"/> <end x="619.23193" y="1572.125"/> </arc> <arc class="production" id="prod_d5202ffd-2d87-4a93-9e81-a024208a1255" source="pr_1bbb9807-f258-4609-8139-f12f2e3216b5_p2" target="mpk1_mpk1_s983_mpk1_mpk1_csa110"> <start x="619.23193" y="1542.125"/> <end x="618.5" y="1476.0"/> </arc> <arc class="consumption" id="addreact_a21847c8-6667-49ea-a24a-883e15d370d4" source="mpk1_mpk1_s488_mpk1_mpk1_sa275" target="pr_1bbb9807-f258-4609-8139-f12f2e3216b5_p1"> <start x="409.51123" y="1923.0094"/> <end x="619.23193" y="1572.125"/> </arc> <arc class="consumption" id="cons_d978c0a9-2673-49d3-b863-500ff350a07d" source="mpk1_mpk1_s937_mpk1_mpk1_sa691" target="pr_8daa4012-066f-4e66-8c38-e6d80b25ed4a_p1"> <start x="554.0" y="2810.0"/> <end x="589.5" y="2811.25"/> </arc> <arc class="production" id="prod_4dbb4dd9-bd09-4db4-8676-6fad991cca58" source="pr_8daa4012-066f-4e66-8c38-e6d80b25ed4a_p2" target="mpk1_mpk1_s938_mpk1_mpk1_sa692"> <start x="619.5" y="2811.25"/> <end x="655.0" y="2812.5"/> </arc> <arc class="catalysis" id="logicarc_e7685fb6-aef2-4dac-9da4-a4b7271a9543" source="logicglyph_7da737ee-a796-4358-83f8-6614e50bb0e9_p2" target="pr_8daa4012-066f-4e66-8c38-e6d80b25ed4a"> <start x="606.5985" y="2820.3218"/> <end x="609.6222" y="2806.3752"/> </arc> <arc class="logic arc" id="modif_421400d7-d6c9-4eb9-a82e-6093da619f91" source="mpk1_mpk1_s603_mpk1_mpk1_sa259" target="logicglyph_7da737ee-a796-4358-83f8-6614e50bb0e9_p1"> <start x="2332.1667" y="2617.8335"/> <next x="2330.0786" y="2799.7793"/> <next x="606.6022" y="2780.0005"/> <end x="606.5985" y="2780.3218"/> </arc> <arc class="logic arc" id="modif_237751e3-a780-419b-85b4-071717136361" source="mpk1_mpk1_s945_mpk1_mpk1_sa698" target="logicglyph_7da737ee-a796-4358-83f8-6614e50bb0e9_p1"> <start x="983.0" y="2102.5"/> <next x="888.5021" y="2392.2815"/> <next x="624.4964" y="2389.048"/> <next x="620.4248" y="2721.4998"/> <end x="606.5985" y="2780.3218"/> </arc> <arc class="consumption" id="cons_1a30f4d9-059f-4b82-940d-d9901d88d998" source="mpk1_mpk1_s942_mpk1_mpk1_sa695" target="pr_8ceebcf1-7fc9-422d-9525-253c6fe7bb54_p1"> <start x="1055.0" y="1901.5"/> <next x="1055.0" y="1965.0"/> <end x="1023.5" y="1965.0"/> </arc> <arc class="production" id="prod_82013201-4b80-415d-8233-700000d88ce7" source="pr_8ceebcf1-7fc9-422d-9525-253c6fe7bb54_p2" target="mpk1_mpk1_s944_mpk1_mpk1_sa696"> <start x="993.5" y="1965.0"/> <next x="962.0" y="1965.0"/> <end x="962.0" y="2005.5"/> </arc> <arc class="catalysis" id="modif_2a1e5649-e430-4f7f-8af3-3472a87f84e8" source="mpk1_mpk1_s1008_mpk1_mpk1_csa113" target="pr_8ceebcf1-7fc9-422d-9525-253c6fe7bb54"> <start x="786.5" y="2039.0"/> <end x="1008.5" y="1970.0"/> </arc> <arc class="consumption" id="cons_cb102f51-a27a-4c47-8ecb-9d9c8998b8e0" source="mpk1_mpk1_s947_mpk1_mpk1_sa697" target="pr_576c034e-e2fe-4cc4-9bab-0d83e21d5f96_p1"> <start x="843.0" y="2082.5"/> <next x="843.0" y="2060.0"/> <end x="898.0" y="2060.0"/> </arc> <arc class="production" id="prod_e111b188-88e8-4ab0-951c-7a9ea69547f1" source="pr_576c034e-e2fe-4cc4-9bab-0d83e21d5f96_p2" target="mpk1_mpk1_s945_mpk1_mpk1_sa698"> <start x="928.0" y="2060.0"/> <next x="983.0" y="2060.0"/> <end x="983.0" y="2077.5"/> </arc> <arc class="catalysis" id="modif_b4c929ab-558b-4afc-8a46-ecf8237344ab" source="mpk1_mpk1_s944_mpk1_mpk1_sa696" target="pr_576c034e-e2fe-4cc4-9bab-0d83e21d5f96"> <start x="962.0" y="2030.5"/> <end x="913.0" y="2055.0"/> </arc> <arc class="consumption" id="cons_ec49cdfa-4b04-49be-b841-39b456319e47" source="mpk1_mpk1_s948_mpk1_mpk1_sa699" target="pr_80722c41-3f99-4362-b38d-fbda7b489f86_p1"> <start x="660.0" y="2593.5"/> <end x="660.0" y="2594.75"/> </arc> <arc class="production" id="prod_9606b03a-ae9f-4507-afbd-5ec0deb08abd" source="pr_80722c41-3f99-4362-b38d-fbda7b489f86_p2" target="mpk1_mpk1_s950_mpk1_mpk1_sa700"> <start x="660.0" y="2624.75"/> <next x="660.0" y="2626.0"/> <next x="660.0" y="2626.0"/> <end x="660.0" y="2658.5"/> </arc> <arc class="catalysis" id="modif_14b4cff4-7b9e-4e68-9db3-1d808d411051" source="mpk1_mpk1_s945_mpk1_mpk1_sa698" target="pr_80722c41-3f99-4362-b38d-fbda7b489f86"> <start x="983.0" y="2102.5"/> <next x="890.00494" y="2399.9985"/> <next x="620.0074" y="2400.0024"/> <next x="620.0103" y="2610.0005"/> <end x="655.0" y="2609.75"/> </arc> <arc class="consumption" id="cons_fa6d38e4-a826-4b53-b73a-d52bc9881d81" source="mpk1_mpk1_s952_mpk1_mpk1_sa702" target="pr_5d8ca5b3-0f3e-4ba8-9320-cb53908e7c09_p1"> <start x="180.0" y="2897.5"/> <next x="180.0" y="2830.0"/> <end x="180.0" y="2845.0"/> </arc> <arc class="production" id="prod_44ffe3fc-958e-4c24-9c75-3df2f9de34d6" source="pr_5d8ca5b3-0f3e-4ba8-9320-cb53908e7c09_p2" target="mpk1_mpk1_s951_mpk1_mpk1_sa701"> <start x="180.0" y="2815.0"/> <next x="180.0" y="2830.0"/> <end x="180.0" y="2762.5"/> </arc> <arc class="catalysis" id="modif_47ad045b-1ebd-4be1-906f-ead7e1b3df36" source="mpk1_mpk1_s950_mpk1_mpk1_sa700" target="pr_5d8ca5b3-0f3e-4ba8-9320-cb53908e7c09"> <start x="660.0" y="2683.5"/> <next x="660.7063" y="2720.2112"/> <next x="235.2785" y="2729.4023"/> <next x="236.54292" y="2834.1157"/> <end x="185.0" y="2835.0"/> </arc> <arc class="consumption" id="cons_420232f2-2616-4e3c-a66e-56fa0ae7153b" source="mpk1_mpk1_s953_mpk1_mpk1_csa112" target="pr_863779c2-2b88-4404-8426-8932f4d03aa1_p1"> <start x="1217.0" y="1952.0"/> <next x="1217.0" y="1969.25"/> <next x="1237.0" y="1969.25"/> <end x="1237.0" y="1961.125"/> </arc> <arc class="production" id="prod_fce83e6f-d9cf-4dd6-acde-73459962c4e1" source="pr_863779c2-2b88-4404-8426-8932f4d03aa1_p2" target="mpk1_mpk1_s574_mpk1_mpk1_sa339"> <start x="1237.0" y="1991.125"/> <next x="1237.0" y="1983.0"/> <next x="1200.5" y="1987.0"/> <next x="1200.5" y="1987.0"/> <end x="1182.0" y="1987.0"/> </arc> <arc class="production" id="prod_c784a771-7104-4b9a-ac94-1117cd616dd7" source="pr_863779c2-2b88-4404-8426-8932f4d03aa1_p2" target="mpk1_mpk1_s575_mpk1_mpk1_sa340"> <start x="1237.0" y="1991.125"/> <next x="1237.0" y="1983.0"/> <next x="1307.0" y="1987.0"/> <end x="1307.0" y="1970.5"/> </arc> <arc class="inhibition" id="modif_66dd5cad-c96c-4646-814a-20b5a1edb9e5" source="mpk1_mpk1_s950_mpk1_mpk1_sa700" target="pr_863779c2-2b88-4404-8426-8932f4d03aa1"> <start x="685.0" y="2671.0"/> <next x="900.3716" y="2669.6975"/> <next x="899.75604" y="2228.934"/> <next x="1070.0509" y="2228.6963"/> <next x="1069.6873" y="1968.2452"/> <end x="1242.0" y="1971.125"/> </arc> <arc class="consumption" id="cons_326c1a60-6624-49d9-acfc-274567cc919b" source="mpk1_mpk1_s578_mpk1_mpk1_sa343" target="pr_458541e7-ccfa-42ab-9a9e-5dd8054a8564_p1"> <start x="764.75" y="2714.0"/> <end x="764.75" y="2713.625"/> </arc> <arc class="production" id="prod_2fc21a37-14d8-4abd-b922-8191f8297029" source="pr_458541e7-ccfa-42ab-9a9e-5dd8054a8564_p2" target="mpk1_mpk1_s957_mpk1_mpk1_sa705"> <start x="764.75" y="2743.625"/> <next x="764.75" y="2743.25"/> <end x="721.5" y="2743.25"/> </arc> <arc class="catalysis" id="modif_3260fe67-33be-4175-b3cd-d939b9747a25" source="mpk1_mpk1_s950_mpk1_mpk1_sa700" target="pr_458541e7-ccfa-42ab-9a9e-5dd8054a8564"> <start x="672.5" y="2683.5"/> <next x="672.50214" y="2728.6292"/> <end x="759.75" y="2728.625"/> </arc> <arc class="consumption" id="cons_43631ec2-55f4-4658-a9a5-cb8b5e553f0e" source="mpk1_mpk1_s958_mpk1_mpk1_sa706" target="pr_b3ba95c0-776b-481f-b3f8-8db040e7bf71_p1"> <start x="289.0" y="3145.5"/> <end x="289.0" y="3137.75"/> </arc> <arc class="production" id="prod_98c3a7fb-15cb-4a14-a23c-adcaac1debe1" source="pr_b3ba95c0-776b-481f-b3f8-8db040e7bf71_p2" target="mpk1_mpk1_s959_mpk1_mpk1_sa707"> <start x="289.0" y="3107.75"/> <next x="289.0" y="3100.0"/> <end x="205.0" y="3100.0"/> </arc> <arc class="catalysis" id="modif_ab83d252-bee7-4f20-8c0a-737e3017abfd" source="mpk1_mpk1_s384_mpk1_mpk1_sa22" target="pr_b3ba95c0-776b-481f-b3f8-8db040e7bf71"> <start x="665.0" y="1327.5"/> <next x="110.14888" y="1320.4735"/> <next x="110.05669" y="3119.992"/> <end x="284.0" y="3122.75"/> </arc> <arc class="consumption" id="cons_a11225eb-ad91-4179-b57d-b632d791a9bf" source="mpk1_mpk1_s960_mpk1_mpk1_sa708" target="pr_69333014-0db8-490e-9fb0-fcfbb54dd0e0_p1"> <start x="960.0" y="1352.5"/> <next x="960.0" y="1430.0"/> <end x="960.0" y="1445.0"/> </arc> <arc class="production" id="prod_62469962-c5fa-4235-9951-6f669a026897" source="pr_69333014-0db8-490e-9fb0-fcfbb54dd0e0_p2" target="mpk1_mpk1_s961_mpk1_mpk1_sa709"> <start x="960.0" y="1415.0"/> <next x="960.0" y="1430.0"/> <end x="960.0" y="1507.5"/> </arc> <arc class="catalysis" id="modif_1c224e96-5203-48a3-9ff5-33e9028b7756" source="mpk1_mpk1_s384_mpk1_mpk1_sa22" target="pr_69333014-0db8-490e-9fb0-fcfbb54dd0e0"> <start x="715.0" y="1327.5"/> <next x="919.86615" y="1330.1362"/> <next x="929.0312" y="1427.0544"/> <end x="955.0" y="1425.0"/> </arc> <arc class="inhibition" id="modif_69e17041-4d38-4002-807a-e3112633f00e" source="mpk1_mpk1_s989_mpk1_mpk1_csa6" target="pr_69333014-0db8-490e-9fb0-fcfbb54dd0e0"> <start x="900.0" y="1439.0"/> <end x="955.0" y="1435.0"/> </arc> <arc class="inhibition" id="modif_ce012b25-6cd6-47a5-8164-6dfc8b8b8586" source="mpk1_mpk1_s963_mpk1_mpk1_sa711" target="pr_69333014-0db8-490e-9fb0-fcfbb54dd0e0"> <start x="2637.5" y="2657.5"/> <next x="2632.0005" y="2270.9973"/> <next x="2009.9962" y="2269.9968"/> <next x="2009.9967" y="1769.9934"/> <next x="1059.9902" y="1769.9923"/> <next x="1059.9906" y="1439.9901"/> <end x="965.0" y="1435.0"/> </arc> <arc class="inhibition" id="modif_f00ff623-ccb1-4fb2-a833-22e112691c01" source="mpk1_mpk1_s977_mpk1_mpk1_sa720" target="pr_69333014-0db8-490e-9fb0-fcfbb54dd0e0"> <start x="2545.0" y="2655.0"/> <next x="2545.3887" y="2272.4556"/> <next x="2011.1255" y="2270.9255"/> <next x="2013.2263" y="1769.6143"/> <next x="1061.1198" y="1770.6307"/> <next x="1059.2039" y="1440.3041"/> <end x="965.0" y="1425.0"/> </arc> <arc class="consumption" id="cons_e6888ecf-7aaf-4606-a031-4df5dca35ae7" source="mpk1_mpk1_s962_mpk1_mpk1_sa710" target="pr_0e79bb98-fc33-49fc-a1e7-67222ad7756d_p1"> <start x="2700.0" y="2602.5"/> <end x="2675.0" y="2615.0"/> </arc> <arc class="production" id="prod_cbc165d3-025b-4b78-b73d-07ce8c813609" source="pr_0e79bb98-fc33-49fc-a1e7-67222ad7756d_p2" target="mpk1_mpk1_s963_mpk1_mpk1_sa711"> <start x="2675.0" y="2645.0"/> <end x="2650.0" y="2657.5"/> </arc> <arc class="catalysis" id="modif_1ad1ed3a-bafe-446f-9cb9-93c432dc6fb0" source="mpk1_mpk1_s603_mpk1_mpk1_sa259" target="pr_0e79bb98-fc33-49fc-a1e7-67222ad7756d"> <start x="2357.1667" y="2605.3335"/> <next x="2671.3008" y="2605.3396"/> <end x="2671.3003" y="2626.6367"/> </arc> <arc class="consumption" id="cons_5c3350f9-c6ad-4073-a391-e0899f6ac1a0" source="mpk1_mpk1_s787_mpk1_mpk1_sa544" target="pr_d0dd53fc-6a16-4b85-b828-b02db7a28c98_p1"> <start x="3383.2144" y="3104.8572"/> <next x="3383.3074" y="3550.2844"/> <end x="2232.9102" y="3550.6768"/> </arc> <arc class="production" id="prod_5e01f37f-e680-48cb-871d-013581d6fe33" source="pr_d0dd53fc-6a16-4b85-b828-b02db7a28c98_p2" target="mpk1_mpk1_s910_mpk1_mpk1_sa668"> <start x="2202.9102" y="3550.6768"/> <next x="1052.513" y="3551.0693"/> <end x="1052.5" y="3488.5"/> </arc> <arc class="consumption" id="cons_ffb128fa-4a51-4919-ae93-d30a6e0a8ab2" source="mpk1_mpk1_s931_mpk1_mpk1_sa686" target="pr_41b8bafb-e98a-4441-a3fc-013dc5ea2783_p1"> <start x="2627.5" y="3152.5"/> <next x="2627.6155" y="3530.2021"/> <end x="1861.3147" y="3532.0908"/> </arc> <arc class="production" id="prod_9377eb30-fc10-483a-a7cf-3789933df140" source="pr_41b8bafb-e98a-4441-a3fc-013dc5ea2783_p2" target="mpk1_mpk1_s910_mpk1_mpk1_sa668"> <start x="1831.3147" y="3532.0908"/> <next x="1065.0139" y="3533.9797"/> <end x="1065.0" y="3488.5"/> </arc> <arc class="consumption" id="cons_2c94c8e3-b854-4467-a668-b33c26c8a969" source="mpk1_mpk1_s952_mpk1_mpk1_sa702" target="pr_096791e9-9248-4efb-81a7-226c5af30fa6_p1"> <start x="155.0" y="2922.5"/> <next x="98.98409" y="2922.5146"/> <end x="99.121155" y="3216.8574"/> </arc> <arc class="production" id="prod_e471210a-916e-4737-b051-11ab45ff99ac" source="pr_096791e9-9248-4efb-81a7-226c5af30fa6_p2" target="mpk1_mpk1_s909_mpk1_mpk1_sa667"> <start x="99.121155" y="3246.8574"/> <next x="99.25822" y="3541.2004"/> <next x="2772.013" y="3540.0151"/> <end x="2772.0" y="3490.5"/> </arc> <arc class="consumption" id="cons_2e7a8b60-cc38-47d7-a5ef-1a3574c09b39" source="mpk1_mpk1_s696_mpk1_mpk1_sa420" target="pr_537cfb81-aebd-41d9-bbbe-49669def01a8_p1"> <start x="3563.663" y="2975.3335"/> <end x="3562.7812" y="3154.167"/> </arc> <arc class="production" id="prod_35ecc5dc-8649-4f08-8df3-98c96828ce62" source="pr_537cfb81-aebd-41d9-bbbe-49669def01a8_p2" target="mpk1_mpk1_s912_mpk1_mpk1_sa670"> <start x="3562.7812" y="3184.167"/> <next x="3561.8992" y="3363.0007"/> <next x="3561.003" y="3559.9949"/> <next x="2440.013" y="3560.0005"/> <end x="2429.0" y="3490.5"/> </arc> <arc class="catalysis" id="modif_6ae873ce-9ef3-4c09-b256-e62bf561a027" source="mpk1_mpk1_s695_mpk1_mpk1_sa419" target="pr_537cfb81-aebd-41d9-bbbe-49669def01a8"> <start x="2979.163" y="2814.8335"/> <next x="3477.9426" y="2814.0889"/> <next x="3480.131" y="3155.4343"/> <end x="3557.7812" y="3169.1443"/> </arc> <arc class="inhibition" id="modif_2b16f39d-bc53-4656-9f95-b680ed43af9d" source="mpk1_mpk1_s578_mpk1_mpk1_sa343" target="pr_537cfb81-aebd-41d9-bbbe-49669def01a8"> <start x="796.25" y="2714.0"/> <next x="799.84735" y="2844.9714"/> <next x="3453.649" y="2845.0647"/> <next x="3460.167" y="3176.051"/> <end x="3557.7585" y="3174.1443"/> </arc> <arc class="consumption" id="cons_e7d4d7ea-82cf-4158-a70f-4caca0fc7845" source="mpk1_mpk1_s938_mpk1_mpk1_sa692" target="pr_051b5b13-d6ed-4813-9685-9fadf488b08a_p1"> <start x="680.0" y="2837.5"/> <next x="679.81665" y="3560.2437"/> <end x="1526.8989" y="3562.181"/> </arc> <arc class="production" id="prod_b30ec06c-93c2-42f1-a837-1fb1bd7a42b8" source="pr_051b5b13-d6ed-4813-9685-9fadf488b08a_p2" target="mpk1_mpk1_s912_mpk1_mpk1_sa670"> <start x="1556.8989" y="3562.181"/> <next x="2403.9812" y="3564.1182"/> <end x="2404.0" y="3490.5"/> </arc> <arc class="consumption" id="cons_4f460978-562f-4118-81f2-5279c6bf4559" source="mpk1_mpk1_s900_mpk1_mpk1_sa658" target="pr_17f384e5-c968-4a93-89a8-3e91f300d087_p1"> <start x="3345.0" y="3326.5"/> <next x="3345.0" y="3427.5"/> <next x="71.16563" y="3427.75"/> <next x="71.00016" y="2903.5"/> <end x="98.00008" y="2903.625"/> </arc> <arc class="production" id="prod_f396ec6f-82eb-4b74-bb34-74fcce097a29" source="pr_17f384e5-c968-4a93-89a8-3e91f300d087_p2" target="mpk1_mpk1_s952_mpk1_mpk1_sa702"> <start x="128.00008" y="2903.625"/> <end x="155.0" y="2903.75"/> </arc> <arc class="consumption" id="cons_4d6457bf-ad71-42d0-8d39-3371c6b51424" source="mpk1_mpk1_s959_mpk1_mpk1_sa707" target="pr_4c48e96c-f4e7-433e-aeae-7319cc736076_p1"> <start x="192.5" y="3112.5"/> <next x="191.85721" y="3248.2703"/> <end x="1743.9026" y="3249.0679"/> </arc> <arc class="production" id="prod_f54678cb-8092-4715-a47d-eb1f508dabab" source="pr_4c48e96c-f4e7-433e-aeae-7319cc736076_p2" target="mpk1_mpk1_s900_mpk1_mpk1_sa658"> <start x="1773.9026" y="3249.0679"/> <next x="3325.948" y="3249.8657"/> <end x="3327.5" y="3301.5"/> </arc> <arc class="consumption" id="cons_4bb33111-621a-424d-97e1-39ece91b3476" source="mpk1_mpk1_s358_mpk1_mpk1_sa240" target="pr_976c1b88-b1ef-4274-ac31-f265b7a95f3c_p1"> <start x="843.0" y="2195.5"/> <next x="844.0082" y="2177.967"/> <end x="1119.0105" y="2177.617"/> </arc> <arc class="production" id="prod_ac0acea9-8836-4d31-8b8b-2c3c0ce7391f" source="pr_976c1b88-b1ef-4274-ac31-f265b7a95f3c_p2" target="mpk1_mpk1_s965_mpk1_mpk1_sa712"> <start x="1149.0105" y="2177.617"/> <next x="1424.0128" y="2177.2668"/> <next x="1948.0226" y="2186.1516"/> <end x="1948.5" y="2209.0"/> </arc> <arc class="catalysis" id="modif_a2852c46-3a91-48bb-844d-7445d795a95c" source="mpk1_mpk1_s983_mpk1_mpk1_csa110" target="pr_976c1b88-b1ef-4274-ac31-f265b7a95f3c"> <start x="677.0" y="1453.25"/> <next x="778.0634" y="1451.686"/> <next x="799.2591" y="2133.3845"/> <next x="1135.7009" y="2135.5637"/> <end x="1134.0045" y="2172.617"/> </arc> <arc class="consumption" id="cons_4d13a112-d563-4d14-a223-6f9a6a8f1d56" source="mpk1_mpk1_s1010_mpk1_mpk1_csa111" target="pr_aa8bf623-7705-47b3-af08-05cdef9a7f09_p1"> <start x="937.0" y="1916.0"/> <end x="856.75" y="1956.5"/> </arc> <arc class="production" id="prod_62ec3003-0b08-47ff-a11c-1392b9a1b204" source="pr_aa8bf623-7705-47b3-af08-05cdef9a7f09_p2" target="mpk1_mpk1_s1008_mpk1_mpk1_csa113"> <start x="826.75" y="1956.5"/> <end x="746.5" y="1997.0"/> </arc> <arc class="catalysis" id="modif_7ee8c1a8-7540-477e-b143-a14b1bb16fe0" source="mpk1_mpk1_s944_mpk1_mpk1_sa696" target="pr_aa8bf623-7705-47b3-af08-05cdef9a7f09"> <start x="949.5" y="2005.5"/> <end x="843.7065" y="1961.1013"/> </arc> <arc class="catalysis" id="modif_72aec72c-d47d-4394-aeb7-9d001c0845f1" source="mpk1_mpk1_s384_mpk1_mpk1_sa22" target="pr_aa8bf623-7705-47b3-af08-05cdef9a7f09"> <start x="702.50116" y="1342.5"/> <next x="702.783" y="1947.0624"/> <end x="839.7935" y="1951.8987"/> </arc> <arc class="consumption" id="cons_8022df0b-5997-4ea7-99a1-b0c505811450" source="mpk1_mpk1_s25_mpk1_mpk1_sa28" target="pr_b5a2f428-32e5-470e-8c96-126813b9d233_p1"> <start x="750.0" y="1759.0"/> <next x="749.8043" y="1783.8333"/> <next x="459.4146" y="1783.3556"/> <next x="454.32516" y="2088.4795"/> <next x="318.79263" y="2089.781"/> <next x="316.99997" y="2177.0"/> <end x="320.2446" y="2216.25"/> </arc> <arc class="consumption" id="cons_b3cf886d-b9f6-44ec-b3f1-07f4dade093c" source="mpk1_mpk1_s1001_mpk1_mpk1_csa35" target="pr_b5a2f428-32e5-470e-8c96-126813b9d233_p1"> <start x="394.0" y="2177.0"/> <next x="316.99997" y="2177.0"/> <end x="320.2446" y="2216.25"/> </arc> <arc class="production" id="prod_a39d71bf-a289-4484-9e11-9d3e5c0a69f4" source="pr_b5a2f428-32e5-470e-8c96-126813b9d233_p2" target="mpk1_mpk1_s1002_mpk1_mpk1_csa37"> <start x="320.2446" y="2246.25"/> <end x="323.25" y="2281.5"/> </arc> <arc class="consumption" id="cons_119d5b2f-16cb-4ce2-b69b-1b183be46559" source="mpk1_mpk1_s973_mpk1_mpk1_sa716" target="pr_824852b1-b6ad-4101-bb0c-ce4816c95466_p1"> <start x="516.5" y="1984.0"/> <next x="572.0" y="1948.0"/> <end x="597.7656" y="1929.0"/> </arc> <arc class="consumption" id="cons_f7f83521-3a82-4267-af74-26af88d169dc" source="mpk1_mpk1_s974_mpk1_mpk1_sa717" target="pr_824852b1-b6ad-4101-bb0c-ce4816c95466_p1"> <start x="539.5" y="2036.5"/> <next x="572.0" y="1948.0"/> <end x="597.7656" y="1929.0"/> </arc> <arc class="production" id="prod_e0cc99be-8bf1-4a17-a5ee-6e2f2944bca5" source="pr_824852b1-b6ad-4101-bb0c-ce4816c95466_p2" target="mpk1_mpk1_s1009_mpk1_mpk1_csa21"> <start x="597.7656" y="1899.0"/> <end x="620.5" y="1884.0"/> </arc> <arc class="consumption" id="cons_f202b0eb-2cae-4eaf-8bfa-2f4c3e5873d3" source="mpk1_mpk1_s973_mpk1_mpk1_sa716" target="pr_4b0a4a13-45c7-4cb7-a712-307bd90d5f5c_p1"> <start x="541.5" y="1996.5"/> <next x="614.75" y="1951.0"/> <end x="742.875" y="1911.9543"/> </arc> <arc class="consumption" id="cons_ddbcea2e-801a-4f14-995e-223a89f70494" source="mpk1_mpk1_s975_mpk1_mpk1_sa718" target="pr_4b0a4a13-45c7-4cb7-a712-307bd90d5f5c_p1"> <start x="639.0" y="2026.0"/> <next x="614.75" y="1951.0"/> <end x="742.875" y="1911.9543"/> </arc> <arc class="production" id="prod_6c35a513-a069-4bcf-8247-5c24d092d48c" source="pr_4b0a4a13-45c7-4cb7-a712-307bd90d5f5c_p2" target="mpk1_mpk1_s1010_mpk1_mpk1_csa111"> <start x="772.875" y="1911.9543"/> <end x="897.0" y="1874.0"/> </arc> <arc class="consumption" id="cons_829aab05-ca25-4304-bbf0-9804ffbbbbc7" source="mpk1_mpk1_s976_mpk1_mpk1_sa719" target="pr_de87ba62-3ef9-4add-9332-97099e7ad92a_p1"> <start x="2585.0" y="2599.0"/> <end x="2571.25" y="2612.0"/> </arc> <arc class="production" id="prod_53311085-8438-4650-9f28-e303d5b61463" source="pr_de87ba62-3ef9-4add-9332-97099e7ad92a_p2" target="mpk1_mpk1_s977_mpk1_mpk1_sa720"> <start x="2571.25" y="2642.0"/> <end x="2557.5" y="2655.0"/> </arc> <arc class="catalysis" id="modif_63378e44-07fc-407b-89f2-366fef7a4094" source="mpk1_mpk1_s603_mpk1_mpk1_sa259" target="pr_de87ba62-3ef9-4add-9332-97099e7ad92a"> <start x="2357.1667" y="2611.5835"/> <end x="2566.762" y="2624.7961"/> </arc> <arc class="consumption" id="cons_1d26a04f-7bf6-47e0-93a1-4d10a444d455" source="akt1_s_akt1_s3_akt1_akt1_sa3" target="pr_8c1b9b4b-2582-415d-af6f-3a057abeb5d9_p1"> <start x="4582.0" y="54.0"/> <next x="4610.0" y="54.0"/> <next x="4610.0" y="120.200005"/> <end x="4610.0" y="160.85"/> </arc> <arc class="consumption" id="cons_b2305edf-e6d2-474f-8ae4-b7774300aa02" source="akt1_s_akt1_s1_akt1_akt1_sa1" target="pr_8c1b9b4b-2582-415d-af6f-3a057abeb5d9_p1"> <start x="4589.0" y="158.8"/> <next x="4601.5" y="158.8"/> <next x="4601.5" y="120.200005"/> <next x="4610.0" y="120.200005"/> <end x="4610.0" y="160.85"/> </arc> <arc class="production" id="prod_6475d936-a911-4b93-a31d-9e06b2da0678" source="pr_8c1b9b4b-2582-415d-af6f-3a057abeb5d9_p2" target="akt1_s_akt1_s6_akt1_akt1_csa1"> <start x="4610.0" y="190.85"/> <next x="4610.0" y="227.5"/> <end x="4669.0" y="227.5"/> </arc> <arc class="consumption" id="cons_3226cc29-5bea-4fde-8dd8-a617abdfa45a" source="akt1_s_akt1_s6_akt1_akt1_csa1" target="pr_77ea9d00-0f89-497e-b15f-839e9feebda0_p1"> <start x="4721.5" y="315.0"/> <next x="4721.5" y="245.0"/> <next x="4743.0" y="245.0"/> <next x="4743.0" y="253.0"/> <next x="4742.9736" y="272.9449"/> <end x="4748.9414" y="272.97244"/> </arc> <arc class="consumption" id="cons_62ee7843-d525-4fbe-a087-acc47243ce50" source="akt1_s_akt1_s856_akt1_akt1_csa2" target="pr_77ea9d00-0f89-497e-b15f-839e9feebda0_p1"> <start x="4468.0" y="275.0"/> <next x="4468.0" y="258.5"/> <next x="4743.0" y="258.5"/> <next x="4743.0" y="253.0"/> <next x="4742.9736" y="272.9449"/> <end x="4748.9414" y="272.97244"/> </arc> <arc class="production" id="prod_6b1c14ab-89a7-47a7-bf59-e5ffb9c746ef" source="pr_77ea9d00-0f89-497e-b15f-839e9feebda0_p2" target="akt1_s_akt1_s20_akt1_akt1_csa3"> <start x="4778.9414" y="272.97244"/> <end x="4784.909" y="273.0"/> </arc> <arc class="consumption" id="cons_dd3b6ce8-d465-429a-aac4-cebb11154378" source="akt1_s_akt1_s21_akt1_akt1_sa12" target="pr_2481197f-bc53-4e69-b7cb-45cd51714d03_p1"> <start x="5246.7485" y="152.16116"/> <end x="5322.5" y="152.16116"/> </arc> <arc class="production" id="prod_48ec7e1b-ed66-4a1e-9988-303d8f47057d" source="pr_2481197f-bc53-4e69-b7cb-45cd51714d03_p2" target="akt1_s_akt1_s22_akt1_akt1_sa13"> <start x="5352.5" y="152.16116"/> <end x="5428.2515" y="152.16116"/> </arc> <arc class="catalysis" id="modif_0e814a8d-7809-41ec-b5dc-30e36cbfbabb" source="akt1_s_akt1_s26_akt1_akt1_csa7" target="pr_2481197f-bc53-4e69-b7cb-45cd51714d03"> <start x="5174.0" y="218.5"/> <end x="5332.5" y="157.16116"/> </arc> <arc class="catalysis" id="modif_3d869d8f-08fe-4324-bb7f-d751b822f866" source="akt1_s_akt1_s20_akt1_akt1_csa3" target="pr_2481197f-bc53-4e69-b7cb-45cd51714d03"> <start x="4885.409" y="317.5"/> <next x="4885.3643" y="290.03934"/> <next x="5337.716" y="289.30054"/> <end x="5337.5" y="157.16116"/> </arc> <arc class="catalysis" id="modif_eee5d708-138c-4a29-8f0f-2518b2cb30d4" source="akt1_s_akt1_s42_akt1_akt1_csa10" target="pr_2481197f-bc53-4e69-b7cb-45cd51714d03"> <start x="5619.0" y="261.0"/> <next x="5757.5317" y="177.9407"/> <next x="5759.3125" y="256.0206"/> <next x="5628.0005" y="255.99995"/> <next x="5342.498" y="255.99431"/> <end x="5342.5" y="157.16116"/> </arc> <arc class="consumption" id="cons_67d0715f-1dcd-46f7-b78a-171315c2b79f" source="akt1_s_akt1_s22_akt1_akt1_sa13" target="pr_b1900332-0df7-496a-97ad-b3b2ef1c3c88_p1"> <start x="5428.2515" y="169.83884"/> <end x="5352.5" y="169.83884"/> </arc> <arc class="production" id="prod_50647a70-bbb7-4aef-8f25-378f174c39dd" source="pr_b1900332-0df7-496a-97ad-b3b2ef1c3c88_p2" target="akt1_s_akt1_s21_akt1_akt1_sa12"> <start x="5322.5" y="169.83884"/> <end x="5246.7485" y="169.83884"/> </arc> <arc class="catalysis" id="modif_10a2509a-70a1-46c0-8b77-69298886c351" source="akt1_s_akt1_s35_akt1_akt1_sa33" target="pr_b1900332-0df7-496a-97ad-b3b2ef1c3c88"> <start x="5265.75" y="625.0"/> <end x="5332.5" y="174.83884"/> </arc> <arc class="consumption" id="cons_19c7a106-74ff-4b46-a84f-15140d0672ae" source="akt1_s_akt1_s24_akt1_akt1_sa15" target="pr_258e6d83-6b96-40f8-8b9c-a237941673d5_p1"> <start x="4500.0" y="196.5"/> <end x="4521.4688" y="219.75"/> </arc> <arc class="production" id="prod_f97ff636-f08c-4ec2-aa06-33614ea27413" source="pr_258e6d83-6b96-40f8-8b9c-a237941673d5_p2" target="akt1_s_akt1_s25_akt1_akt1_sa16"> <start x="4521.4688" y="249.75"/> <end x="4542.9375" y="273.0"/> </arc> <arc class="consumption" id="cons_c90c9fb3-1a3a-45f2-8cff-557a63b49f26" source="akt1_s_akt1_s856_akt1_akt1_csa2" target="pr_1e4d6fab-daff-4b91-9fd2-a391b91a2062_p1"> <start x="4518.0" y="330.0"/> <next x="4741.5" y="330.0"/> <next x="4741.5" y="323.0"/> <next x="4752.0" y="323.0"/> <end x="4752.0205" y="323.8775"/> </arc> <arc class="consumption" id="cons_73f563bf-6fab-42d6-be8d-577e943030a1" source="akt1_s_akt1_s25_akt1_akt1_sa16" target="pr_1e4d6fab-daff-4b91-9fd2-a391b91a2062_p1"> <start x="4582.9375" y="253.0"/> <next x="4582.9375" y="372.0"/> <next x="4752.0" y="372.0"/> <next x="4752.0" y="323.0"/> <end x="4752.0205" y="323.8775"/> </arc> <arc class="production" id="prod_7db310d9-2d19-4456-ad5f-516cbb68e96f" source="pr_1e4d6fab-daff-4b91-9fd2-a391b91a2062_p2" target="akt1_s_akt1_s26_akt1_akt1_csa7"> <start x="4752.0205" y="293.8775"/> <next x="4752.0356" y="298.755"/> <next x="5085.967" y="299.2453"/> <end x="5086.0" y="276.5"/> </arc> <arc class="consumption" id="cons_ae7a547a-7c37-4805-af15-354ca12fcb1d" source="akt1_s_akt1_s22_akt1_akt1_sa13" target="pr_b2e36f73-b72a-4054-ac3a-788563354f53_p1"> <start x="5466.394" y="172.5485"/> <next x="5345.0" y="213.0"/> <end x="5339.452" y="218.25"/> </arc> <arc class="consumption" id="cons_95941acb-d4ba-42a3-be0b-ff2082977b0a" source="akt1_s_akt1_s675_akt1_akt1_sa35" target="pr_b2e36f73-b72a-4054-ac3a-788563354f53_p1"> <start x="5292.0" y="222.0"/> <next x="5345.0" y="213.0"/> <end x="5339.452" y="218.25"/> </arc> <arc class="production" id="prod_2ab14dca-bc20-4352-bed5-64883646487a" source="pr_b2e36f73-b72a-4054-ac3a-788563354f53_p2" target="akt1_s_akt1_s865_akt1_akt1_csa8"> <start x="5339.452" y="248.25"/> <end x="5335.0" y="249.5"/> </arc> <arc class="stimulation" id="direct_ac67cd3e-2083-4d8b-b59f-0b40c8f7786f" source="akt1_s_akt1_s53_akt1_akt1_csa12" target="akt1_s_akt1_s24_akt1_akt1_sa15"> <start x="6347.5" y="444.0"/> <next x="6347.575" y="392.04654"/> <next x="4481.2476" y="389.34378"/> <end x="4481.5" y="215.0"/> </arc> <arc class="consumption" id="cons_8a479fe3-b56d-4571-bc80-bef0bb004597" source="akt1_s_akt1_s856_akt1_akt1_csa11" target="pr_83671e5c-23cc-4807-94c4-99e6935ba8e5_p1"> <start x="6353.5" y="258.0"/> <next x="6268.5" y="317.0"/> <end x="6027.25" y="347.236"/> </arc> <arc class="consumption" id="cons_ec34eabb-544a-4235-a604-9fbfc0a9148d" source="akt1_s_akt1_s53_akt1_akt1_csa12" target="pr_83671e5c-23cc-4807-94c4-99e6935ba8e5_p1"> <start x="6347.5" y="387.0"/> <next x="6268.5" y="317.0"/> <end x="6027.25" y="347.236"/> </arc> <arc class="production" id="prod_82c57403-0b49-4089-8162-b0b57039722b" source="pr_83671e5c-23cc-4807-94c4-99e6935ba8e5_p2" target="akt1_s_akt1_s42_akt1_akt1_csa10"> <start x="5997.25" y="347.236"/> <end x="5901.0" y="360.36282"/> </arc> <arc class="modulation" id="modif_7b4adc99-3a8e-44d9-8406-ab041dc833a2" source="akt1_s_akt1_s35_akt1_akt1_sa33" target="pr_83671e5c-23cc-4807-94c4-99e6935ba8e5"> <start x="5305.75" y="645.0"/> <end x="6007.87" y="352.78745"/> </arc> <arc class="consumption" id="addreact_2c707cbc-39dc-4770-9d15-69572cf4a31c" source="akt1_s_akt1_s22_akt1_akt1_sa13" target="pr_83671e5c-23cc-4807-94c4-99e6935ba8e5_p1"> <start x="5453.0" y="173.5"/> <end x="6027.25" y="347.236"/> </arc> <arc class="consumption" id="addreact_dfca79ec-16a0-4562-9e6c-65187bbcac88" source="akt1_s_akt1_s1_akt1_akt1_sa27" target="pr_83671e5c-23cc-4807-94c4-99e6935ba8e5_p1"> <start x="6305.5454" y="172.85455"/> <end x="6027.25" y="347.236"/> </arc> <arc class="consumption" id="addreact_5e6ee91d-c07b-44df-bca3-c3ad6d429cb6" source="akt1_s_akt1_s3_akt1_akt1_sa47" target="pr_83671e5c-23cc-4807-94c4-99e6935ba8e5_p1"> <start x="6460.5" y="82.0"/> <end x="6027.25" y="347.236"/> </arc> <arc class="consumption" id="addreact_f9c1d525-7b06-46fc-8773-22342e708e09" source="akt1_s_akt1_s25_akt1_akt1_sa16" target="pr_83671e5c-23cc-4807-94c4-99e6935ba8e5_p1"> <start x="4622.9375" y="253.0"/> <end x="6027.25" y="347.236"/> </arc> <arc class="consumption" id="addreact_10d5c885-8106-4e5f-8f08-c1259d28efa7" source="akt1_s_akt1_s602_akt1_akt1_sa41" target="pr_83671e5c-23cc-4807-94c4-99e6935ba8e5_p1"> <start x="6397.0" y="529.0"/> <end x="6027.25" y="347.236"/> </arc> <arc class="consumption" id="cons_32044025-927e-4790-b860-6f7b56ffaea0" source="akt1_s_akt1_s35_akt1_akt1_sa55" target="pr_91564ba6-7cc9-430c-829a-a5fcdecfd1a3_p1"> <start x="5268.75" y="742.0"/> <end x="5267.25" y="718.5"/> </arc> <arc class="production" id="prod_f2cd52d1-65f6-4a23-a041-452e725b9125" source="pr_91564ba6-7cc9-430c-829a-a5fcdecfd1a3_p2" target="akt1_s_akt1_s35_akt1_akt1_sa33"> <start x="5267.25" y="688.5"/> <end x="5265.75" y="665.0"/> </arc> <arc class="catalysis" id="modif_9acc22bb-6dd7-46db-a0f1-95ea294d24a7" source="akt1_s_akt1_s57_akt1_akt1_sa56" target="pr_91564ba6-7cc9-430c-829a-a5fcdecfd1a3"> <start x="5183.25" y="742.0"/> <end x="5262.254" y="703.69464"/> </arc> <arc class="inhibition" id="modif_818976ac-bfc5-4c7f-b02b-ba49696cb769" source="akt1_s_akt1_s425_akt1_akt1_sa66" target="pr_91564ba6-7cc9-430c-829a-a5fcdecfd1a3"> <start x="5609.75" y="742.0"/> <next x="5609.75" y="703.30383"/> <end x="5272.246" y="703.30536"/> </arc> <arc class="consumption" id="cons_3df6a809-ab8c-47c1-83df-88d99823ddce" source="akt1_s_akt1_s35_akt1_akt1_sa55" target="pr_553b537d-2810-420a-a25d-1f54bb3a1d88_p1"> <start x="5268.75" y="782.0"/> <end x="5164.7812" y="841.5"/> </arc> <arc class="production" id="prod_d9dba21e-cd06-454b-a4b9-4fc4d110adaf" source="pr_553b537d-2810-420a-a25d-1f54bb3a1d88_p2" target="akt1_s_akt1_s112_akt1_akt1_sa60"> <start x="5134.7812" y="841.5"/> <end x="5030.8125" y="901.0"/> </arc> <arc class="catalysis" id="modif_ba115e4d-5f95-4ac8-aa9c-4488bc56834e" source="akt1_s_akt1_s60_akt1_akt1_sa59" target="pr_553b537d-2810-420a-a25d-1f54bb3a1d88"> <start x="5167.8315" y="698.0"/> <end x="5147.545" y="837.0281"/> </arc> <arc class="consumption" id="cons_bda46f3c-ef14-413a-8d75-3d0f64700a1d" source="akt1_s_akt1_s112_akt1_akt1_sa60" target="pr_738cffe1-0424-424b-8860-4150351b5144_p1"> <start x="5030.8125" y="941.0"/> <end x="4990.6562" y="981.5"/> </arc> <arc class="production" id="prod_94dd92a3-8c3a-4eb4-a33d-6c7a45032b1f" source="pr_738cffe1-0424-424b-8860-4150351b5144_p2" target="akt1_s_akt1_s114_akt1_akt1_sa62"> <start x="4990.6562" y="1011.5"/> <end x="4950.5" y="1052.0"/> </arc> <arc class="consumption" id="cons_5450030f-72d7-41f6-a50b-3ab90009d687" source="akt1_s_akt1_s35_akt1_akt1_sa55" target="pr_61fb46a1-4bd9-4d7a-a67c-580ead565a19_p1"> <start x="5228.75" y="782.0"/> <end x="5242.3125" y="826.5"/> </arc> <arc class="production" id="prod_e36fb8ac-ce32-4e98-8d50-c1538c6fa41c" source="pr_61fb46a1-4bd9-4d7a-a67c-580ead565a19_p2" target="akt1_s_akt1_s63_akt1_akt1_sa63"> <start x="5242.3125" y="856.5"/> <end x="5255.875" y="901.0"/> </arc> <arc class="catalysis" id="modif_90e8f6c5-8199-4477-bcac-6914e566b1f7" source="akt1_s_akt1_s60_akt1_akt1_sa59" target="pr_61fb46a1-4bd9-4d7a-a67c-580ead565a19"> <start x="5178.7505" y="698.0"/> <end x="5238.549" y="847.48615"/> </arc> <arc class="inhibition" id="modif_5723f3d3-904d-46ae-9bd4-c12c80d0afc6" source="akt1_s_akt1_s57_akt1_akt1_sa56" target="pr_61fb46a1-4bd9-4d7a-a67c-580ead565a19"> <start x="5143.25" y="762.0"/> <end x="5236.326" y="837.73627"/> </arc> <arc class="consumption" id="cons_6fc8b45d-a0ba-4165-8e01-73a852c0bfb6" source="akt1_s_akt1_s22_akt1_akt1_sa13" target="pr_03a498f8-7e50-4949-ac70-8f02dd4167e7_p1"> <start x="5453.0" y="173.5"/> <next x="5453.0" y="244.00002"/> <end x="5469.0" y="244.26724"/> </arc> <arc class="consumption" id="cons_82353e6b-e828-4ef5-ac46-589a97d3e1c0" source="akt1_s_akt1_s87_akt1_akt1_sa68" target="pr_03a498f8-7e50-4949-ac70-8f02dd4167e7_p1"> <start x="6004.75" y="489.0"/> <next x="5453.0" y="244.00002"/> <end x="5469.0" y="244.26724"/> </arc> <arc class="production" id="prod_821e5e3b-9cb6-40ca-93e6-8a145468974f" source="pr_03a498f8-7e50-4949-ac70-8f02dd4167e7_p2" target="akt1_s_akt1_s867_akt1_akt1_csa13"> <start x="5499.0" y="244.26724"/> <end x="5511.0" y="244.5"/> </arc> <arc class="catalysis" id="modif_309089e6-e8cb-4dcf-846f-f46cc0f75ca3" source="akt1_s_akt1_s865_akt1_akt1_csa8" target="pr_03a498f8-7e50-4949-ac70-8f02dd4167e7"> <start x="5401.0" y="338.0"/> <end x="5483.957" y="249.26706"/> </arc> <arc class="catalysis" id="modif_7c2d0b79-b134-465c-b034-4ee6964b7b13" source="akt1_s_akt1_s132_akt1_akt1_csa19" target="pr_03a498f8-7e50-4949-ac70-8f02dd4167e7"> <start x="6259.5" y="182.0"/> <end x="5488.9565" y="249.31017"/> </arc> <arc class="consumption" id="cons_69007c43-620e-4e9b-a7f9-89a820ed52d2" source="akt1_s_akt1_s867_akt1_akt1_csa13" target="pr_82d8b5cd-b92b-45a8-b74b-e5680315a8f5_p1"> <start x="5586.0" y="300.5"/> <end x="5587.5" y="364.75"/> </arc> <arc class="production" id="prod_dcac9935-b223-4797-ab23-280b264408a3" source="pr_82d8b5cd-b92b-45a8-b74b-e5680315a8f5_p2" target="akt1_s_akt1_s866_akt1_akt1_csa14"> <start x="5587.5" y="394.75"/> <end x="5589.0" y="459.0"/> </arc> <arc class="catalysis" id="modif_87fc5c32-1a40-4cb4-992d-45a3e3e32e69" source="akt1_s_akt1_s862_akt1_akt1_csa16" target="pr_82d8b5cd-b92b-45a8-b74b-e5680315a8f5"> <start x="5281.8335" y="498.875"/> <end x="5582.501" y="379.84464"/> </arc> <arc class="inhibition" id="modif_0ba47ab1-2ed8-48b9-a078-dbae3826cd0d" source="akt1_s_akt1_s861_akt1_akt1_csa50" target="pr_82d8b5cd-b92b-45a8-b74b-e5680315a8f5"> <start x="5068.1665" y="460.625"/> <end x="5582.5957" y="384.84372"/> </arc> <arc class="catalysis" id="modif_7c498e00-4f39-4e5a-bda7-40097536bca0" source="akt1_s_akt1_s867_akt1_akt1_csa13" target="pr_82d8b5cd-b92b-45a8-b74b-e5680315a8f5"> <start x="5611.0" y="244.5"/> <next x="5826.855" y="244.56937"/> <next x="5826.8115" y="379.73065"/> <end x="5592.499" y="379.65536"/> </arc> <arc class="consumption" id="cons_7aed97e1-9980-43f1-8652-bc1b5a1449bb" source="akt1_s_akt1_s91_akt1_akt1_sa77" target="pr_c715f489-71f9-4e75-b6ee-463949308795_p1"> <start x="6004.75" y="557.5"/> <end x="6004.75" y="558.25"/> </arc> <arc class="production" id="prod_9166e35b-9181-440d-839f-fd344bc848c3" source="pr_c715f489-71f9-4e75-b6ee-463949308795_p2" target="akt1_s_akt1_s87_akt1_akt1_sa68"> <start x="6004.75" y="528.25"/> <end x="6004.75" y="529.0"/> </arc> <arc class="catalysis" id="modif_456bb5ba-97d1-44c7-bf37-1b4cfb9dce46" source="akt1_s_akt1_s862_akt1_akt1_csa16" target="pr_c715f489-71f9-4e75-b6ee-463949308795"> <start x="5281.8335" y="498.875"/> <end x="5999.75" y="543.25"/> </arc> <arc class="consumption" id="cons_3037f2d8-2f53-4103-b91e-8628b4a47699" source="akt1_s_akt1_s867_akt1_akt1_csa13" target="pr_b58c079c-988c-4821-a4d2-d66e25d52ec0_p1"> <start x="5536.0" y="300.5"/> <end x="5755.375" y="394.75"/> </arc> <arc class="production" id="prod_0614c66f-0952-4f28-91ad-e589e165594c" source="pr_b58c079c-988c-4821-a4d2-d66e25d52ec0_p2" target="akt1_s_akt1_s87_akt1_akt1_sa68"> <start x="5785.375" y="394.75"/> <end x="6004.75" y="489.0"/> </arc> <arc class="catalysis" id="modif_2c2d355c-f15b-474e-b77d-7ae382b12286" source="akt1_s_akt1_s888_akt1_akt1_csa17" target="pr_b58c079c-988c-4821-a4d2-d66e25d52ec0"> <start x="5944.0" y="211.0"/> <end x="5767.6016" y="388.24554"/> </arc> <arc class="inhibition" id="modif_49ecae94-4d8b-45e1-b8da-ebe9dfb06117" source="akt1_s_akt1_s132_akt1_akt1_csa19" target="pr_b58c079c-988c-4821-a4d2-d66e25d52ec0"> <start x="6209.0" y="208.75"/> <end x="5776.8794" y="391.97653"/> </arc> <arc class="catalysis" id="modif_6d63c5c5-88b9-4972-b81f-d6b6e1e154ff" source="akt1_s_akt1_s887_akt1_akt1_csa81" target="pr_b58c079c-988c-4821-a4d2-d66e25d52ec0"> <start x="6069.0" y="227.0"/> <end x="5776.8794" y="391.97653"/> </arc> <arc class="consumption" id="cons_2d49d8df-2685-46a5-ace3-4b2cbc35c3f9" source="akt1_s_akt1_s35_akt1_akt1_sa55" target="pr_6804a811-c088-4d28-ae4f-f6febd7f3552_p1"> <start x="5288.75" y="782.0"/> <end x="5227.75" y="841.5"/> </arc> <arc class="production" id="prod_ac6b6100-82b5-441e-bf9d-c08111797a35" source="pr_6804a811-c088-4d28-ae4f-f6febd7f3552_p2" target="akt1_s_akt1_s115_akt1_akt1_sa91"> <start x="5197.75" y="841.5"/> <end x="5136.75" y="901.0"/> </arc> <arc class="catalysis" id="modif_5fd4ffcd-7a52-4914-8d56-2be1223c8ade" source="akt1_s_akt1_s60_akt1_akt1_sa59" target="pr_6804a811-c088-4d28-ae4f-f6febd7f3552"> <start x="5176.2275" y="698.0"/> <end x="5213.605" y="834.4808"/> </arc> <arc class="consumption" id="cons_d49f19c2-0d51-4ea6-92f4-cdae13d02ee1" source="akt1_s_akt1_s115_akt1_akt1_sa91" target="pr_0b65741c-95ad-4a69-aaa2-ef1025824be3_p1"> <start x="5136.75" y="941.0"/> <end x="5096.125" y="981.0"/> </arc> <arc class="production" id="prod_efd9a59e-1e91-4d93-8959-393b51d522d2" source="pr_0b65741c-95ad-4a69-aaa2-ef1025824be3_p2" target="akt1_s_akt1_s116_akt1_akt1_sa92"> <start x="5096.125" y="1011.0"/> <end x="5055.5" y="1051.0"/> </arc> <arc class="consumption" id="cons_8a08764f-3134-4294-b9d0-6f139dafa5ed" source="akt1_s_akt1_s130_akt1_akt1_sa105" target="pr_79be36f1-8fe7-4ae0-ad51-da4eebe2d3d6_p1"> <start x="6366.0" y="1374.25"/> <end x="6394.625" y="1374.25"/> </arc> <arc class="production" id="prod_b235fc87-3b57-4cd1-a910-0e0082069d4c" source="pr_79be36f1-8fe7-4ae0-ad51-da4eebe2d3d6_p2" target="akt1_s_akt1_s131_akt1_akt1_sa106"> <start x="6424.625" y="1374.25"/> <end x="6453.25" y="1374.25"/> </arc> <arc class="catalysis" id="modif_653297ce-e179-43d8-a1dd-e197d4ffe1aa" source="akt1_s_akt1_s204_akt1_akt1_sa154" target="pr_79be36f1-8fe7-4ae0-ad51-da4eebe2d3d6"> <start x="6410.0" y="1413.5"/> <end x="6409.625" y="1379.25"/> </arc> <arc class="consumption" id="cons_02061ced-3446-4865-a95b-1d3c639306c1" source="akt1_s_akt1_s131_akt1_akt1_sa106" target="pr_cacdda45-3a5a-4730-8746-5ed81ba681a4_p1"> <start x="6453.25" y="1354.25"/> <end x="6424.625" y="1354.25"/> </arc> <arc class="production" id="prod_8a82b66d-64b4-425e-a59c-0e7f1c9aaacb" source="pr_cacdda45-3a5a-4730-8746-5ed81ba681a4_p2" target="akt1_s_akt1_s130_akt1_akt1_sa105"> <start x="6394.625" y="1354.25"/> <end x="6366.0" y="1354.25"/> </arc> <arc class="catalysis" id="modif_76e833a8-6ae6-4243-989a-d5dfd39c213d" source="akt1_s_akt1_s876_akt1_akt1_csa20" target="pr_cacdda45-3a5a-4730-8746-5ed81ba681a4"> <start x="6338.722" y="1286.5354"/> <end x="6409.625" y="1349.25"/> </arc> <arc class="catalysis" id="modif_f95df5dd-6427-4ff9-b823-ebf76f2d91f0" source="akt1_s_akt1_s634_akt1_akt1_sa123" target="pr_cacdda45-3a5a-4730-8746-5ed81ba681a4"> <start x="6603.722" y="1293.5555"/> <end x="6414.625" y="1349.25"/> </arc> <arc class="consumption" id="cons_eeb0e58f-1670-412b-ba32-2bef09ba7057" source="akt1_s_akt1_s91_akt1_akt1_sa77" target="pr_e8f7970a-a681-4d8f-9b5d-8def3761b7ce_p1"> <start x="6004.75" y="597.5"/> <end x="6004.125" y="597.25"/> </arc> <arc class="production" id="prod_f9daec21-e196-417f-ba8a-e95ab79a655e" source="pr_e8f7970a-a681-4d8f-9b5d-8def3761b7ce_p2" target="akt1_s_akt1_s136_akt1_akt1_sa112"> <start x="6004.125" y="627.25"/> <end x="6003.5" y="627.0"/> </arc> <arc class="catalysis" id="modif_eb517752-6326-4139-a631-e1f26264fb31" source="akt1_s_akt1_s135_akt1_akt1_sa109" target="pr_e8f7970a-a681-4d8f-9b5d-8def3761b7ce"> <start x="5615.0" y="682.0"/> <end x="5999.3413" y="607.0428"/> </arc> <arc class="consumption" id="cons_298d71a2-12ab-438e-8520-efe64c1ef46c" source="akt1_s_akt1_s136_akt1_akt1_sa112" target="pr_a902891e-099c-49db-9922-4e3aa3d50750_p1"> <start x="6043.5" y="647.0"/> <next x="6106.5" y="446.0"/> <end x="6172.0024" y="380.5"/> </arc> <arc class="consumption" id="cons_6b30d10c-7b59-4f4a-aa44-9fcc945db38c" source="akt1_s_akt1_s81_akt1_akt1_sa73" target="pr_a902891e-099c-49db-9922-4e3aa3d50750_p1"> <start x="6135.75" y="517.0"/> <next x="6106.5" y="446.0"/> <end x="6172.0024" y="380.5"/> </arc> <arc class="production" id="prod_f3b314a3-7e0d-4cad-b6ba-a613ee630a4b" source="pr_a902891e-099c-49db-9922-4e3aa3d50750_p2" target="akt1_s_akt1_s132_akt1_akt1_csa19"> <start x="6172.0024" y="350.5"/> <end x="6234.25" y="289.0"/> </arc> <arc class="consumption" id="cons_493a4d59-1fe5-4a7c-a5c8-e8b87cf81f9d" source="akt1_s_akt1_s876_akt1_akt1_csa20" target="pr_61788941-cd42-48e5-a783-6eef74021614_p1"> <start x="6389.222" y="1225.0354"/> <end x="6394.222" y="1225.0354"/> </arc> <arc class="production" id="prod_b73131eb-f255-4fb9-a819-b281d4f00fda" source="pr_61788941-cd42-48e5-a783-6eef74021614_p2" target="akt1_s_akt1_s877_akt1_akt1_csa21"> <start x="6424.222" y="1225.0354"/> <end x="6429.222" y="1225.0354"/> </arc> <arc class="catalysis" id="modif_54266da2-8aaf-4b84-92b3-ae20957c850c" source="akt1_s_akt1_s866_akt1_akt1_csa14" target="pr_61788941-cd42-48e5-a783-6eef74021614"> <start x="5564.0" y="571.0"/> <end x="6409.222" y="1220.0354"/> </arc> <arc class="consumption" id="cons_3f71e87a-00fb-4015-97fa-83ace467c33d" source="akt1_s_akt1_s132_akt1_akt1_csa19" target="pr_e37b0752-bedb-4cdf-9316-cda47edd79c6_p1"> <start x="6259.5" y="289.0"/> <end x="5926.75" y="374.0"/> </arc> <arc class="production" id="prod_9e36402b-5513-4f61-bd1a-a517f5d4298a" source="pr_e37b0752-bedb-4cdf-9316-cda47edd79c6_p2" target="akt1_s_akt1_s866_akt1_akt1_csa14"> <start x="5896.75" y="374.0"/> <end x="5564.0" y="459.0"/> </arc> <arc class="consumption" id="cons_3449e9b0-2d8a-402d-914d-74b57ec12757" source="akt1_s_akt1_s155_akt1_akt1_csa22" target="pr_76dfff84-8190-423d-8f6b-92fbb4d451a0_p1"> <start x="5750.0" y="1173.5"/> <end x="5761.0" y="1185.422"/> </arc> <arc class="production" id="prod_34f9b07c-b2cf-4e04-8a4b-e2e812177895" source="pr_76dfff84-8190-423d-8f6b-92fbb4d451a0_p2" target="akt1_s_akt1_s156_akt1_akt1_sa119"> <start x="5791.0" y="1185.422"/> <next x="5802.0" y="1197.344"/> <end x="5818.222" y="1149.5555"/> </arc> <arc class="production" id="prod_2013e7e8-20e8-4661-85b9-3ed8cbbcdb77" source="pr_76dfff84-8190-423d-8f6b-92fbb4d451a0_p2" target="akt1_s_akt1_s157_akt1_akt1_sa120"> <start x="5791.0" y="1185.422"/> <next x="5802.0" y="1197.344"/> <end x="5828.0" y="1243.5555"/> </arc> <arc class="catalysis" id="modif_5f2ae24e-267f-42f8-b4b6-6062b063b0f9" source="akt1_s_akt1_s159_akt1_akt1_sa121" target="pr_76dfff84-8190-423d-8f6b-92fbb4d451a0"> <start x="6230.222" y="1282.5354"/> <end x="5778.084" y="1180.8771"/> </arc> <arc class="consumption" id="cons_a961a08b-00d4-4011-9f30-60bf68e7d824" source="akt1_s_akt1_s159_akt1_akt1_sa121" target="pr_7f8231d3-77c6-4716-b742-d4da813b6974_p1"> <start x="6230.222" y="1282.5354"/> <next x="6205.111" y="1193.5555"/> <end x="6233.6665" y="1210.053"/> </arc> <arc class="consumption" id="cons_a6c1e27e-4930-497c-aef8-0b1e024a72b1" source="akt1_s_akt1_s157_akt1_akt1_sa120" target="pr_7f8231d3-77c6-4716-b742-d4da813b6974_p1"> <start x="5848.0" y="1263.5555"/> <next x="6205.111" y="1193.5555"/> <end x="6233.6665" y="1210.053"/> </arc> <arc class="production" id="prod_7e0b576d-0758-4d97-bdbf-643796196a62" source="pr_7f8231d3-77c6-4716-b742-d4da813b6974_p2" target="akt1_s_akt1_s876_akt1_akt1_csa20"> <start x="6263.6665" y="1210.053"/> <end x="6288.222" y="1225.0354"/> </arc> <arc class="inhibition" id="modif_01f34f5c-5871-4081-99b9-296054225a4d" source="akt1_s_akt1_s648_akt1_akt1_sa434" target="pr_7f8231d3-77c6-4716-b742-d4da813b6974"> <start x="6084.8823" y="1249.2941"/> <end x="6242.2197" y="1212.9578"/> </arc> <arc class="inhibition" id="modif_62fed50f-0580-41bf-a773-1b83dd107af3" source="akt1_s_akt1_s651_akt1_akt1_sa436" target="pr_7f8231d3-77c6-4716-b742-d4da813b6974"> <start x="6122.8823" y="1282.0"/> <end x="6251.5713" y="1216.4999"/> </arc> <arc class="consumption" id="cons_bf4c8f7b-5fa9-4cf3-ac5a-844526335a0c" source="akt1_s_akt1_s877_akt1_akt1_csa21" target="pr_fa963ae6-ff8f-492d-bc7b-5271b8415d23_p1"> <start x="6529.222" y="1225.0354"/> <end x="6528.222" y="1226.5511"/> </arc> <arc class="production" id="prod_800091b9-4233-492e-a088-205193e0c8a0" source="pr_fa963ae6-ff8f-492d-bc7b-5271b8415d23_p2" target="akt1_s_akt1_s159_akt1_akt1_sa122"> <start x="6558.222" y="1226.5511"/> <next x="6557.222" y="1228.0669"/> <end x="6561.222" y="1208.5354"/> </arc> <arc class="production" id="prod_eb3e11f8-b915-4624-be40-25723c68059c" source="pr_fa963ae6-ff8f-492d-bc7b-5271b8415d23_p2" target="akt1_s_akt1_s634_akt1_akt1_sa123"> <start x="6558.222" y="1226.5511"/> <next x="6557.222" y="1228.0669"/> <end x="6563.722" y="1253.5555"/> </arc> <arc class="consumption" id="cons_2d22a70e-05e6-41ae-8f12-aa26ba2648a0" source="akt1_s_akt1_s879_akt1_akt1_csa24" target="pr_570ca9b0-2292-4b53-98c7-31dd837b488a_p1"> <start x="6225.6597" y="1725.0"/> <end x="6220.2393" y="1722.75"/> </arc> <arc class="production" id="prod_9c5724bf-add6-4c35-a0e9-7d125fb2f0e3" source="pr_570ca9b0-2292-4b53-98c7-31dd837b488a_p2" target="akt1_s_akt1_s880_akt1_akt1_csa28"> <start x="6250.2393" y="1722.75"/> <end x="6244.8193" y="1720.5"/> </arc> <arc class="necessary stimulation" id="modif_9dc02e4c-7115-4f40-97a7-e4d689eaf3bc" source="akt1_s_akt1_s131_akt1_akt1_sa106" target="pr_570ca9b0-2292-4b53-98c7-31dd837b488a"> <start x="6473.25" y="1384.25"/> <end x="6234.096" y="1717.8824"/> </arc> <arc class="consumption" id="cons_f7e54a8e-53b0-4a77-ba4a-fdd187e30c86" source="akt1_s_akt1_s880_akt1_akt1_csa28" target="pr_7b389596-1a01-473e-bf43-15a7c908b158_p1"> <start x="6419.8193" y="1720.5"/> <end x="6416.08" y="1719.5"/> </arc> <arc class="production" id="prod_f4bbba2b-c8d3-4b22-8539-8ec1cff01ca0" source="pr_7b389596-1a01-473e-bf43-15a7c908b158_p2" target="akt1_s_akt1_s881_akt1_akt1_csa29"> <start x="6446.08" y="1719.5"/> <end x="6442.3403" y="1718.5"/> </arc> <arc class="catalysis" id="modif_58f67b6b-c9d8-4edc-ab0c-495ef160b483" source="akt1_s_akt1_s880_akt1_akt1_csa28" target="pr_7b389596-1a01-473e-bf43-15a7c908b158"> <start x="6332.3193" y="1845.0"/> <next x="6332.3364" y="1859.5166"/> <next x="6431.682" y="1859.3988"/> <end x="6431.5225" y="1724.4803"/> </arc> <arc class="consumption" id="cons_edfe6faf-03f9-4a72-801e-d0404afa357d" source="akt1_s_akt1_s881_akt1_akt1_csa29" target="pr_130d04ed-48cf-4569-b59b-5d9651e1f393_p1"> <start x="6608.3403" y="1718.5"/> <end x="6604.42" y="1717.25"/> </arc> <arc class="production" id="prod_c25e12d1-035d-4784-8cec-318ad4bd527d" source="pr_130d04ed-48cf-4569-b59b-5d9651e1f393_p2" target="akt1_s_akt1_s885_akt1_akt1_csa25"> <start x="6634.42" y="1717.25"/> <end x="6630.5" y="1716.0"/> </arc> <arc class="catalysis" id="modif_babdd95a-85eb-462b-a23f-685a559a4a21" source="akt1_s_akt1_s881_akt1_akt1_csa29" target="pr_130d04ed-48cf-4569-b59b-5d9651e1f393"> <start x="6608.3403" y="1779.75"/> <next x="6619.9106" y="1779.764"/> <end x="6619.9805" y="1722.2185"/> </arc> <arc class="consumption" id="cons_d404c0d4-67a0-4445-8e33-690e05734444" source="akt1_s_akt1_s885_akt1_akt1_csa25" target="pr_cc4449ee-76a8-41e0-96b6-1fc1e6736c7e_p1"> <start x="6716.0" y="1836.0"/> <end x="6717.125" y="1850.5"/> </arc> <arc class="production" id="prod_0e17de8a-a17c-4fa0-9d65-414e95d29bde" source="pr_cc4449ee-76a8-41e0-96b6-1fc1e6736c7e_p2" target="akt1_s_akt1_s886_akt1_akt1_csa30"> <start x="6717.125" y="1880.5"/> <end x="6718.25" y="1895.0"/> </arc> <arc class="catalysis" id="modif_3edf5920-27f6-406d-9637-6b112661989b" source="akt1_s_akt1_s251_akt1_akt1_sa177" target="pr_cc4449ee-76a8-41e0-96b6-1fc1e6736c7e"> <start x="6745.0" y="1871.0"/> <end x="6722.1216" y="1865.3094"/> </arc> <arc class="consumption" id="cons_acc8e950-4996-433e-9a6c-4936d890be3d" source="akt1_s_akt1_s886_akt1_akt1_csa30" target="pr_b3312447-2c52-45b6-8e87-88fb2103d001_p1"> <start x="6632.75" y="2015.0"/> <end x="6603.1943" y="2016.5"/> </arc> <arc class="production" id="prod_ed3a2159-f11f-4862-8259-2e90c93a62d5" source="pr_b3312447-2c52-45b6-8e87-88fb2103d001_p2" target="akt1_s_akt1_s882_akt1_akt1_csa31"> <start x="6573.1943" y="2016.5"/> <end x="6543.6387" y="2018.0"/> </arc> <arc class="catalysis" id="modif_eb039389-8a2f-474a-bc11-dc847184d471" source="akt1_s_akt1_s886_akt1_akt1_csa30" target="pr_b3312447-2c52-45b6-8e87-88fb2103d001"> <start x="6675.5" y="2135.0"/> <next x="6675.508" y="2157.2012"/> <next x="6593.4062" y="2157.2292"/> <end x="6593.36" y="2021.329"/> </arc> <arc class="catalysis" id="modif_559a3af7-cb14-4a44-801b-e6551a0ec1d9" source="akt1_s_akt1_s866_akt1_akt1_csa14" target="pr_b3312447-2c52-45b6-8e87-88fb2103d001"> <start x="5539.0" y="571.0"/> <end x="6583.029" y="2011.671"/> </arc> <arc class="consumption" id="cons_c007f0a6-7be1-4fff-be79-614c954c7134" source="akt1_s_akt1_s882_akt1_akt1_csa31" target="pr_bf9be23e-8fb8-4bfd-b273-781c63ca2057_p1"> <start x="6372.6387" y="2018.0"/> <end x="6359.3193" y="2016.5989"/> </arc> <arc class="production" id="prod_d85c11ad-50fe-4fd9-b388-bf6c7efc6d0c" source="pr_bf9be23e-8fb8-4bfd-b273-781c63ca2057_p2" target="akt1_s_akt1_s883_akt1_akt1_csa32"> <start x="6329.3193" y="2016.5989"/> <next x="6316.0" y="2015.1979"/> <next x="6277.6084" y="2014.3436"/> <next x="6277.59" y="2012.3789"/> <end x="6264.8193" y="2012.5"/> </arc> <arc class="production" id="prod_aa0286e2-a532-44fd-90ed-d151d537c021" source="pr_bf9be23e-8fb8-4bfd-b273-781c63ca2057_p2" target="akt1_s_akt1_s274_akt1_akt1_sa147"> <start x="6329.3193" y="2016.5989"/> <next x="6316.0" y="2015.1979"/> <end x="6316.0" y="2156.0"/> </arc> <arc class="inhibition" id="modif_fc7105d4-bd64-438a-b37b-34e0d8357633" source="akt1_s_akt1_s884_akt1_akt1_csa34" target="pr_bf9be23e-8fb8-4bfd-b273-781c63ca2057"> <start x="5930.4688" y="1891.0"/> <next x="5930.4746" y="1900.5293"/> <next x="6344.496" y="1900.2671"/> <end x="6344.5664" y="2011.605"/> </arc> <arc class="consumption" id="cons_ca2385f7-30db-42fe-98c5-713c6bb7d356" source="akt1_s_akt1_s205_akt1_akt1_sa155" target="pr_7087eaa7-068e-44d2-9c8a-7cd6745c0e05_p1"> <start x="6097.5" y="2292.5"/> <end x="6072.854" y="2168.25"/> </arc> <arc class="production" id="prod_983c4541-55ea-407a-a0d3-446be3521561" source="pr_7087eaa7-068e-44d2-9c8a-7cd6745c0e05_p2" target="akt1_s_akt1_s883_akt1_akt1_csa32"> <start x="6072.854" y="2138.25"/> <next x="6048.208" y="2014.0"/> <end x="6093.8193" y="2012.5"/> </arc> <arc class="production" id="prod_c8f40030-0270-4f1c-bb3e-ec7e86bd846f" source="pr_7087eaa7-068e-44d2-9c8a-7cd6745c0e05_p2" target="akt1_s_akt1_s884_akt1_akt1_csa34"> <start x="6072.854" y="2138.25"/> <next x="6048.208" y="2014.0"/> <end x="6015.9688" y="2011.0"/> </arc> <arc class="consumption" id="cons_98775e72-4f31-4732-93c1-b2f9fbde5bb0" source="akt1_s_akt1_s274_akt1_akt1_sa147" target="pr_7013a741-0f66-45d7-a63b-ef88ce4695dd_p1"> <start x="6276.0" y="2176.0"/> <next x="6199.0" y="2187.2017"/> <end x="6154.0" y="2188.3906"/> </arc> <arc class="consumption" id="cons_e39a5d9c-d7ad-44eb-88a3-86cd6a26bd86" source="akt1_s_akt1_s290_akt1_akt1_sa200" target="pr_7013a741-0f66-45d7-a63b-ef88ce4695dd_p1"> <start x="6152.0" y="2273.5"/> <next x="6199.0" y="2187.2017"/> <end x="6154.0" y="2188.3906"/> </arc> <arc class="production" id="prod_cc53fbc4-31de-452c-b90f-663a23dc1bd5" source="pr_7013a741-0f66-45d7-a63b-ef88ce4695dd_p2" target="akt1_s_akt1_s289_akt1_akt1_csa37"> <start x="6124.0" y="2188.3906"/> <end x="6083.0" y="2189.5"/> </arc> <arc class="modulation" id="modif_74d27d34-4802-49e1-8c1e-ed2349ee3424" source="akt1_s_akt1_s131_akt1_akt1_sa106" target="pr_7013a741-0f66-45d7-a63b-ef88ce4695dd"> <start x="6493.25" y="1384.25"/> <end x="6144.098" y="2193.2905"/> </arc> <arc class="inhibition" id="modif_95db57a6-71ff-4dea-8dc1-10776f03a095" source="akt1_s_akt1_s876_akt1_akt1_csa20" target="pr_7013a741-0f66-45d7-a63b-ef88ce4695dd"> <start x="6288.222" y="1286.5354"/> <end x="6143.9" y="2183.2925"/> </arc> <arc class="consumption" id="cons_fe586225-9fe6-4075-ba2e-45a6c187be80" source="akt1_s_akt1_s883_akt1_akt1_csa32" target="pr_9dd36598-c1b0-423b-ad85-0da2ebc82b93_p1"> <start x="6093.8193" y="1892.5"/> <end x="5492.144" y="1572.75"/> </arc> <arc class="production" id="prod_bcfb7cbf-63dd-4ec0-877c-38d2ed6fcbc2" source="pr_9dd36598-c1b0-423b-ad85-0da2ebc82b93_p2" target="akt1_s_akt1_s318_akt1_akt1_csa40"> <start x="5462.144" y="1572.75"/> <end x="4860.4688" y="1253.0"/> </arc> <arc class="consumption" id="cons_3bed25cc-d525-473b-977f-79438362ef6f" source="akt1_s_akt1_s318_akt1_akt1_csa40" target="pr_a7cc3574-fdee-42ce-a4b6-b70e08f1ef5c_p1"> <start x="4780.4688" y="1193.0"/> <next x="4658.0" y="1183.6719"/> <end x="4654.6445" y="1208.5859"/> </arc> <arc class="consumption" id="cons_a282b46a-eb74-44c8-bbf8-788fff3f7b1b" source="akt1_s_akt1_s868_akt1_akt1_csa38" target="pr_a7cc3574-fdee-42ce-a4b6-b70e08f1ef5c_p1"> <start x="4657.75" y="1141.0"/> <next x="4658.0" y="1183.6719"/> <end x="4654.6445" y="1208.5859"/> </arc> <arc class="production" id="prod_5f65babd-b27f-4ac5-84d6-ebdb99d18aa1" source="pr_a7cc3574-fdee-42ce-a4b6-b70e08f1ef5c_p2" target="akt1_s_akt1_s869_akt1_akt1_csa39"> <start x="4654.6445" y="1238.5859"/> <end x="4651.625" y="1259.5"/> </arc> <arc class="catalysis" id="modif_ade09bc2-007f-48ed-9a31-010df38b4b41" source="akt1_s_akt1_s318_akt1_akt1_csa40" target="pr_a7cc3574-fdee-42ce-a4b6-b70e08f1ef5c"> <start x="4780.4688" y="1223.0"/> <end x="4659.627" y="1224.0049"/> </arc> <arc class="consumption" id="cons_fddbce5d-6053-4bb7-bc72-a223ad834dc0" source="akt1_s_akt1_s869_akt1_akt1_csa39" target="pr_1998b608-119d-486c-b426-d163f4091e48_p1"> <start x="4651.625" y="1492.5"/> <end x="4651.34" y="1498.5"/> </arc> <arc class="production" id="prod_c4d1b0d4-658d-4096-974d-0debae856b4d" source="pr_1998b608-119d-486c-b426-d163f4091e48_p2" target="akt1_s_akt1_s870_akt1_akt1_csa42"> <start x="4651.34" y="1528.5"/> <next x="4651.054" y="1534.5"/> <end x="4651.625" y="1590.5"/> </arc> <arc class="production" id="prod_2be8e498-bc0d-4ed2-94cb-cd80ac6957db" source="pr_1998b608-119d-486c-b426-d163f4091e48_p2" target="akt1_s_akt1_s349_akt1_akt1_sa226"> <start x="4651.34" y="1528.5"/> <next x="4651.054" y="1534.5"/> <end x="4938.5" y="1577.5"/> </arc> <arc class="production" id="addprod_eb9a81ac-3a1e-4072-8dc2-2c62e490d47e" source="pr_1998b608-119d-486c-b426-d163f4091e48_p2" target="akt1_s_akt1_s355_akt1_akt1_sa231"> <start x="4651.34" y="1528.5"/> <end x="4523.5" y="1528.5"/> </arc> <arc class="consumption" id="cons_dbc37595-263b-45e7-8e46-7041e3e76961" source="akt1_s_akt1_s359_akt1_akt1_sa235" target="pr_5aff70c5-0f71-4a57-b027-fdb503a6eb98_p1"> <start x="5104.0" y="1617.0"/> <end x="5104.75" y="1622.5"/> </arc> <arc class="production" id="prod_f080a58f-30b4-402b-93e8-5b250bf53db4" source="pr_5aff70c5-0f71-4a57-b027-fdb503a6eb98_p2" target="akt1_s_akt1_s361_akt1_akt1_sa236"> <start x="5104.75" y="1652.5"/> <end x="5105.5" y="1658.0"/> </arc> <arc class="catalysis" id="modif_8d46a33a-f86f-45d8-9d05-3a5cf82f27a2" source="akt1_s_akt1_s297_akt1_akt1_sa208" target="pr_5aff70c5-0f71-4a57-b027-fdb503a6eb98"> <start x="4981.0" y="1760.0"/> <end x="5099.7534" y="1637.6829"/> </arc> <arc class="catalysis" id="modif_ab4c7ec4-246a-4612-bcdb-20bcda0ac9ae" source="akt1_s_akt1_s376_akt1_akt1_sa244" target="pr_5aff70c5-0f71-4a57-b027-fdb503a6eb98"> <start x="5146.0" y="1542.0"/> <next x="5157.0005" y="1542.001"/> <next x="5156.9917" y="1637.3214"/> <end x="5109.7466" y="1637.3171"/> </arc> <arc class="consumption" id="cons_a58b2a37-fed7-48be-927f-695f43b6f9fb" source="akt1_s_akt1_s349_akt1_akt1_sa226" target="pr_1dadef62-12bf-410d-a5f7-da3276e58cce_p1"> <start x="4938.5" y="1617.5"/> <end x="4939.75" y="1673.75"/> </arc> <arc class="production" id="prod_ef9a4b64-eb5a-4e09-b8bb-964933a91e37" source="pr_1dadef62-12bf-410d-a5f7-da3276e58cce_p2" target="akt1_s_akt1_s297_akt1_akt1_sa208"> <start x="4939.75" y="1703.75"/> <end x="4941.0" y="1760.0"/> </arc> <arc class="catalysis" id="modif_ae4cf7b2-d664-40f7-9370-476719876eac" source="akt1_s_akt1_s363_akt1_akt1_sa238" target="pr_1dadef62-12bf-410d-a5f7-da3276e58cce"> <start x="5222.25" y="1678.0"/> <end x="4944.749" y="1688.6624"/> </arc> <arc class="consumption" id="cons_e469a619-a519-465c-8233-1a0e86b4cf41" source="akt1_s_akt1_s38_akt1_akt1_sa237" target="pr_e731fac3-c7d2-46a2-a860-4d2a6ffc00bf_p1"> <start x="5263.25" y="1623.0"/> <end x="5262.75" y="1625.5"/> </arc> <arc class="production" id="prod_b7055b83-496c-47da-8442-31fd2b17fd7a" source="pr_e731fac3-c7d2-46a2-a860-4d2a6ffc00bf_p2" target="akt1_s_akt1_s363_akt1_akt1_sa238"> <start x="5262.75" y="1655.5"/> <end x="5262.25" y="1658.0"/> </arc> <arc class="catalysis" id="modif_2311911c-d1d1-48e8-b02d-0058efe7319b" source="akt1_s_akt1_s38_akt1_akt1_sa237" target="pr_e731fac3-c7d2-46a2-a860-4d2a6ffc00bf"> <start x="5223.25" y="1603.0"/> <next x="5202.247" y="1603.0029"/> <next x="5202.2524" y="1640.365"/> <end x="5257.752" y="1640.3572"/> </arc> <arc class="consumption" id="cons_680ef0b2-8fa5-49d0-af62-7109fbbac62b" source="akt1_s_akt1_s364_akt1_akt1_sa239" target="pr_c621aa31-0224-4c58-ba7d-5f551e7e8904_p1"> <start x="5270.25" y="1780.0"/> <end x="5270.25" y="1788.0"/> </arc> <arc class="production" id="prod_c1bed743-5728-4ce5-a213-fd82148288c1" source="pr_c621aa31-0224-4c58-ba7d-5f551e7e8904_p2" target="akt1_s_akt1_s366_akt1_akt1_sa240"> <start x="5270.25" y="1818.0"/> <end x="5270.25" y="1826.0"/> </arc> <arc class="catalysis" id="modif_751cecbc-4e4a-42c2-88f0-f4f09ce427b0" source="akt1_s_akt1_s367_akt1_akt1_sa241" target="pr_c621aa31-0224-4c58-ba7d-5f551e7e8904"> <start x="5159.0" y="1754.0"/> <next x="5159.002" y="1803.0038"/> <end x="5265.25" y="1803.0"/> </arc> <arc class="consumption" id="cons_ebcf132c-b09a-4d12-abb1-0604b20dad98" source="akt1_s_akt1_s366_akt1_akt1_sa240" target="pr_17677eeb-d39a-4878-be53-e64f3dc67202_p1"> <start x="5213.25" y="1852.5"/> <end x="5128.875" y="1853.0"/> </arc> <arc class="production" id="prod_187b7bd6-8feb-481d-a2e4-99f3166f9ce1" source="pr_17677eeb-d39a-4878-be53-e64f3dc67202_p2" target="akt1_s_akt1_s372_akt1_akt1_sa242"> <start x="5098.875" y="1853.0"/> <end x="5014.5" y="1853.5"/> </arc> <arc class="catalysis" id="modif_30e22987-7a1b-4aa5-9771-83f7a9332af0" source="akt1_s_akt1_s297_akt1_akt1_sa208" target="pr_17677eeb-d39a-4878-be53-e64f3dc67202"> <start x="4941.0" y="1800.0"/> <next x="4941.0" y="1796.7029"/> <next x="5113.8525" y="1796.7123"/> <end x="5113.8496" y="1848.0001"/> </arc> <arc class="catalysis" id="modif_a5571da9-fcb8-4b11-8293-6470a30c9a8e" source="akt1_s_akt1_s767_akt1_akt1_sa509" target="pr_17677eeb-d39a-4878-be53-e64f3dc67202"> <start x="4813.7104" y="2446.0"/> <end x="5113.9004" y="1857.9999"/> </arc> <arc class="consumption" id="cons_cae4c624-0c0e-422d-9ba9-9247b40beb8a" source="akt1_s_akt1_s381_akt1_akt1_csa44" target="pr_80dc5877-a9df-4341-8dfa-eb15844271e1_p1"> <start x="5215.0" y="2062.5"/> <end x="5249.75" y="2062.5"/> </arc> <arc class="production" id="prod_7755f2f3-1257-4e51-ac4a-c7b9c5d7d26d" source="pr_80dc5877-a9df-4341-8dfa-eb15844271e1_p2" target="akt1_s_akt1_s383_akt1_akt1_csa45"> <start x="5279.75" y="2062.5"/> <end x="5314.5" y="2062.5"/> </arc> <arc class="catalysis" id="modif_06f6e17c-4658-49dc-aca0-cfce2f339b05" source="akt1_s_akt1_s297_akt1_akt1_sa208" target="pr_80dc5877-a9df-4341-8dfa-eb15844271e1"> <start x="4921.0" y="1800.0"/> <end x="5264.75" y="2057.5"/> </arc> <arc class="consumption" id="cons_d252d14a-66ec-4d3a-9005-0d81d99cb507" source="akt1_s_akt1_s383_akt1_akt1_csa45" target="pr_237f86ca-16aa-4a14-b777-65bdfe8420b5_p1"> <start x="5364.5" y="2122.5"/> <end x="5363.7812" y="2154.0"/> </arc> <arc class="production" id="prod_fb6bc9a9-1879-48d2-8028-e7a7f9fad12a" source="pr_237f86ca-16aa-4a14-b777-65bdfe8420b5_p2" target="akt1_s_akt1_s382_akt1_akt1_sa248"> <start x="5363.7812" y="2184.0"/> <next x="5363.062" y="2215.5"/> <end x="5354.125" y="2277.5"/> </arc> <arc class="production" id="prod_d1fd2b39-4b49-44c6-b9f6-6316dbb94ffb" source="pr_237f86ca-16aa-4a14-b777-65bdfe8420b5_p2" target="akt1_s_akt1_s379_akt1_akt1_sa246"> <start x="5363.7812" y="2184.0"/> <next x="5363.062" y="2215.5"/> <end x="5450.0" y="2220.5"/> </arc> <arc class="consumption" id="cons_ac4f3532-f530-45dd-ab95-a43e1285dbfc" source="akt1_s_akt1_s379_akt1_akt1_sa246" target="pr_a614b87b-407f-46f2-a94d-9340b01a5725_p1"> <start x="5490.0" y="2200.5"/> <end x="5490.0" y="2152.75"/> </arc> <arc class="production" id="prod_5d249552-e4b0-4887-b38a-4940d03ef35b" source="pr_a614b87b-407f-46f2-a94d-9340b01a5725_p2" target="akt1_s_akt1_s388_akt1_akt1_sa252"> <start x="5490.0" y="2122.75"/> <end x="5490.0" y="2075.0"/> </arc> <arc class="catalysis" id="logicarc_0877f6e2-ba5f-4c78-a1dc-8f538ae486cb" source="logicglyph_49c9e617-3cb5-41f0-adb2-6b8f188c6ffd_p2" target="pr_a614b87b-407f-46f2-a94d-9340b01a5725"> <start x="5632.0225" y="1396.2623"/> <end x="5495.0" y="2132.75"/> </arc> <arc class="logic arc" id="modif_288aa730-c409-4411-bee0-edf351cb0ea9" source="akt1_s_akt1_s874_akt1_akt1_csa70" target="logicglyph_49c9e617-3cb5-41f0-adb2-6b8f188c6ffd_p1"> <start x="5777.0" y="957.0"/> <end x="5632.0225" y="1356.2623"/> </arc> <arc class="logic arc" id="modif_e7a9cf3f-3a75-4fd0-9e69-7550665f6579" source="akt1_s_akt1_s623_akt1_akt1_sa424" target="logicglyph_49c9e617-3cb5-41f0-adb2-6b8f188c6ffd_p1"> <start x="5931.0" y="1077.0"/> <end x="5632.0225" y="1356.2623"/> </arc> <arc class="logic arc" id="modif_5079b59f-7d76-4a89-b94e-028ca4e5e875" source="akt1_s_akt1_s624_akt1_akt1_sa425" target="logicglyph_49c9e617-3cb5-41f0-adb2-6b8f188c6ffd_p1"> <start x="5880.0" y="1077.0"/> <end x="5632.0225" y="1356.2623"/> </arc> <arc class="consumption" id="cons_e45d2073-bce7-4357-b06b-ae6eec1c1ee9" source="akt1_s_akt1_s870_akt1_akt1_csa42" target="pr_6dfaa30b-4e4e-48c8-9c07-8573e69ab3a8_p1"> <start x="4651.625" y="1859.5"/> <next x="4650.5" y="1888.5"/> <end x="4646.7197" y="1900.5"/> </arc> <arc class="consumption" id="cons_65d40869-4bab-4b8e-86ba-2988a6408800" source="akt1_s_akt1_s372_akt1_akt1_sa242" target="pr_6dfaa30b-4e4e-48c8-9c07-8573e69ab3a8_p1"> <start x="4900.5" y="1853.5"/> <next x="4650.5" y="1888.5"/> <end x="4646.7197" y="1900.5"/> </arc> <arc class="production" id="prod_ed7f7ce2-dcef-46a1-9b1d-0d8cab64d249" source="pr_6dfaa30b-4e4e-48c8-9c07-8573e69ab3a8_p2" target="akt1_s_akt1_s871_akt1_akt1_csa46"> <start x="4646.7197" y="1930.5"/> <end x="4643.5" y="1938.5"/> </arc> <arc class="consumption" id="addreact_f168c64f-a698-4cc6-b75f-a511a28ae0b7" source="akt1_s_akt1_s361_akt1_akt1_sa236" target="pr_6dfaa30b-4e4e-48c8-9c07-8573e69ab3a8_p1"> <start x="5065.5" y="1698.0"/> <end x="4646.7197" y="1900.5"/> </arc> <arc class="consumption" id="addreact_9df7c076-87b6-4047-9443-a4f1c3a734a8" source="akt1_s_akt1_s411_akt1_akt1_sa265" target="pr_6dfaa30b-4e4e-48c8-9c07-8573e69ab3a8_p1"> <start x="4854.0" y="1959.0"/> <end x="4646.7197" y="1900.5"/> </arc> <arc class="consumption" id="addreact_0c51e8d2-09c9-4763-97fd-ec9e8ea35546" source="akt1_s_akt1_s413_akt1_akt1_sa267" target="pr_6dfaa30b-4e4e-48c8-9c07-8573e69ab3a8_p1"> <start x="4523.0" y="1884.0"/> <end x="4646.7197" y="1900.5"/> </arc> <arc class="consumption" id="addreact_7977c5f6-0f0e-4ec5-9a86-b0f46996e9a8" source="akt1_s_akt1_s382_akt1_akt1_sa248" target="pr_6dfaa30b-4e4e-48c8-9c07-8573e69ab3a8_p1"> <start x="5314.125" y="2277.5"/> <end x="4646.7197" y="1900.5"/> </arc> <arc class="consumption" id="cons_22cded4e-ba38-4e6f-9c0b-0ebf3b159d38" source="akt1_s_akt1_s871_akt1_akt1_csa46" target="pr_cbe73549-d7e7-4819-9810-9b74db6ad39f_p1"> <start x="4643.5" y="2260.5"/> <end x="4643.25" y="2281.75"/> </arc> <arc class="production" id="prod_c3d2269a-9c4c-480e-b375-daf1ceb334bd" source="pr_cbe73549-d7e7-4819-9810-9b74db6ad39f_p2" target="akt1_s_akt1_s415_akt1_akt1_sa269"> <start x="4643.25" y="2311.75"/> <end x="4643.0" y="2333.0"/> </arc> <arc class="consumption" id="cons_ee0f33bf-4116-442a-8eeb-a582f94c94de" source="akt1_s_akt1_s872_akt1_akt1_csa48" target="pr_6c2068c6-426c-4116-8fc5-f173846e567b_p1"> <start x="5118.0" y="2300.0"/> <next x="5094.5" y="2300.0"/> <end x="5082.25" y="2300.0"/> </arc> <arc class="consumption" id="cons_00a41198-addd-4d5d-af1f-de2f985e614b" source="akt1_s_akt1_s419_akt1_akt1_sa272" target="pr_6c2068c6-426c-4116-8fc5-f173846e567b_p1"> <start x="5095.0" y="2400.0"/> <next x="5094.5" y="2300.0"/> <end x="5082.25" y="2300.0"/> </arc> <arc class="production" id="prod_c74abdca-c878-4076-9c46-165392f83193" source="pr_6c2068c6-426c-4116-8fc5-f173846e567b_p2" target="akt1_s_akt1_s420_akt1_akt1_csa49"> <start x="5052.25" y="2300.0"/> <end x="5044.0" y="2300.0"/> </arc> <arc class="consumption" id="addreact_f707d7b1-9460-4189-b981-b6552de61749" source="akt1_s_akt1_s297_akt1_akt1_sa208" target="pr_6c2068c6-426c-4116-8fc5-f173846e567b_p1"> <start x="4921.0" y="1800.0"/> <end x="5082.25" y="2300.0"/> </arc> <arc class="consumption" id="cons_042599ea-e2b1-454a-9501-6da21138bceb" source="akt1_s_akt1_s420_akt1_akt1_csa49" target="pr_52eabbb7-e000-4be9-8492-89d0e4c93257_p1"> <start x="4842.0" y="2300.0"/> <end x="4777.5" y="2324.0"/> </arc> <arc class="production" id="prod_f4804746-b44c-4e85-976c-147fdcc7214e" source="pr_52eabbb7-e000-4be9-8492-89d0e4c93257_p2" target="akt1_s_akt1_s415_akt1_akt1_sa269"> <start x="4747.5" y="2324.0"/> <end x="4683.0" y="2348.0"/> </arc> <arc class="consumption" id="cons_98fc8bbd-d7c4-4a03-b377-2963ac6e0b7c" source="akt1_s_akt1_s35_akt1_akt1_sa55" target="pr_a2b224be-d446-4abb-b90b-61afa117b8a6_p1"> <start x="5308.75" y="762.0"/> <end x="5348.75" y="762.0"/> </arc> <arc class="production" id="prod_3e9fa835-77b5-4d92-a04d-dfe2a1c31a13" source="pr_a2b224be-d446-4abb-b90b-61afa117b8a6_p2" target="akt1_s_akt1_s56_akt1_akt1_sa277"> <start x="5378.75" y="762.0"/> <end x="5418.75" y="762.0"/> </arc> <arc class="catalysis" id="modif_2078a45f-9683-4b10-851d-bc4b93cb017d" source="akt1_s_akt1_s135_akt1_akt1_sa109" target="pr_a2b224be-d446-4abb-b90b-61afa117b8a6"> <start x="5535.0" y="662.0"/> <end x="5363.75" y="767.0"/> </arc> <arc class="consumption" id="cons_20724fcf-48fc-412e-b991-b47a6994a37a" source="akt1_s_akt1_s56_akt1_akt1_sa277" target="pr_05bed02e-1abf-451c-9e0f-314179812cb0_p1"> <start x="5498.75" y="762.0"/> <end x="5519.25" y="762.0"/> </arc> <arc class="production" id="prod_32c58dcc-ab79-4660-88ac-1d1435d15d7e" source="pr_05bed02e-1abf-451c-9e0f-314179812cb0_p2" target="akt1_s_akt1_s425_akt1_akt1_sa66"> <start x="5549.25" y="762.0"/> <end x="5569.75" y="762.0"/> </arc> <arc class="catalysis" id="modif_fc0e9b05-cd3b-44bc-82c6-0f660c1cae72" source="akt1_s_akt1_s499_akt1_akt1_sa336" target="pr_05bed02e-1abf-451c-9e0f-314179812cb0"> <start x="5974.0" y="381.0"/> <end x="5534.25" y="757.0"/> </arc> <arc class="consumption" id="cons_002fef97-e32d-458e-a8f7-b2e53a83290b" source="akt1_s_akt1_s427_akt1_akt1_sa279" target="pr_b3f46093-b859-4d23-8b96-62e06bdd6c63_p1"> <start x="4696.75" y="922.0"/> <end x="4702.8125" y="922.0"/> </arc> <arc class="production" id="prod_a1a9c9fb-4a25-4d9c-beab-ad74475d0d68" source="pr_b3f46093-b859-4d23-8b96-62e06bdd6c63_p2" target="akt1_s_akt1_s428_akt1_akt1_sa278"> <start x="4732.8125" y="922.0"/> <end x="4738.875" y="922.0"/> </arc> <arc class="catalysis" id="modif_fd38e229-cad4-411f-a6f5-0d6fea67bca3" source="akt1_s_akt1_s862_akt1_akt1_csa16" target="pr_b3f46093-b859-4d23-8b96-62e06bdd6c63"> <start x="5191.8335" y="575.375"/> <end x="4717.8125" y="917.0"/> </arc> <arc class="consumption" id="cons_759344fd-dca1-448c-b0c1-3f1c2b7164c6" source="akt1_s_akt1_s428_akt1_akt1_sa278" target="pr_bfa8694a-5e9c-4d8b-b65a-93351c02a69a_p1"> <start x="4818.875" y="922.0"/> <end x="4831.375" y="922.0"/> </arc> <arc class="production" id="prod_cacbee43-8b56-4082-99c4-2a1cfa9a0812" source="pr_bfa8694a-5e9c-4d8b-b65a-93351c02a69a_p2" target="akt1_s_akt1_s429_akt1_akt1_sa280"> <start x="4861.375" y="922.0"/> <end x="4873.875" y="922.0"/> </arc> <arc class="catalysis" id="modif_7eb81d32-4492-4ef1-b3ed-7f310cc4c4a2" source="akt1_s_akt1_s363_akt1_akt1_sa238" target="pr_bfa8694a-5e9c-4d8b-b65a-93351c02a69a"> <start x="5282.25" y="1658.0"/> <end x="4846.375" y="927.0"/> </arc> <arc class="consumption" id="cons_a41a7398-9b69-49a6-aa6f-e0ec7fafeb7e" source="akt1_s_akt1_s862_akt1_akt1_csa16" target="pr_9368ecca-fc17-4f61-93ce-aadce0c2cef2_p1"> <start x="5101.8335" y="498.875"/> <end x="5100.0" y="498.875"/> </arc> <arc class="production" id="prod_8e86f86a-905c-4347-84fb-16b43545b2bb" source="pr_9368ecca-fc17-4f61-93ce-aadce0c2cef2_p2" target="akt1_s_akt1_s861_akt1_akt1_csa50"> <start x="5070.0" y="498.875"/> <end x="5068.1665" y="498.875"/> </arc> <arc class="catalysis" id="modif_763ad55d-1afa-44b3-87c1-3967f62a4bec" source="akt1_s_akt1_s297_akt1_akt1_sa208" target="pr_9368ecca-fc17-4f61-93ce-aadce0c2cef2"> <start x="4961.0" y="1760.0"/> <end x="5085.0" y="503.875"/> </arc> <arc class="consumption" id="cons_ed0aec6c-e4a2-410e-a21b-b8e3db4d8cf1" source="akt1_s_akt1_s861_akt1_akt1_csa50" target="pr_389940de-9e6e-4e0d-a52b-299312c1b817_p1"> <start x="4888.1665" y="498.875"/> <next x="4882.375" y="498.0"/> <end x="4880.9375" y="496.22107"/> </arc> <arc class="consumption" id="cons_8004b94d-fcbe-499b-bc37-b42a79ffd132" source="akt1_s_akt1_s676_akt1_akt1_sa291" target="pr_389940de-9e6e-4e0d-a52b-299312c1b817_p1"> <start x="4978.5" y="377.0"/> <next x="4882.375" y="498.0"/> <end x="4880.9375" y="496.22107"/> </arc> <arc class="production" id="prod_d070e351-276e-4138-8e75-c56ca8eccf06" source="pr_389940de-9e6e-4e0d-a52b-299312c1b817_p2" target="akt1_s_akt1_s860_akt1_akt1_csa51"> <start x="4850.9375" y="496.22107"/> <end x="4853.5" y="494.875"/> </arc> <arc class="consumption" id="cons_d1f3a8f9-1aec-4d95-9379-eb4e29217f70" source="akt1_s_akt1_s456_akt1_akt1_sa302" target="pr_cfb860ce-b5e8-4ea3-885d-a957797df07a_p1"> <start x="5599.5" y="912.0"/> <end x="5598.0" y="971.8069"/> </arc> <arc class="production" id="prod_1dd72afd-56e1-4fc1-843e-53367a4cdadd" source="pr_cfb860ce-b5e8-4ea3-885d-a957797df07a_p2" target="akt1_s_akt1_s741_akt1_akt1_sa305"> <start x="5598.0" y="1001.8069"/> <end x="5596.5" y="1061.6138"/> </arc> <arc class="catalysis" id="modif_ea6cae6b-b920-48c1-b25b-4b81d6ee3753" source="akt1_s_akt1_s429_akt1_akt1_sa280" target="pr_cfb860ce-b5e8-4ea3-885d-a957797df07a"> <start x="4913.875" y="942.0"/> <end x="5593.101" y="981.70764"/> </arc> <arc class="catalysis" id="modif_b6a2e8a3-8dc2-44f2-8eb9-57b5fc67cdb6" source="akt1_s_akt1_s866_akt1_akt1_csa14" target="pr_cfb860ce-b5e8-4ea3-885d-a957797df07a"> <start x="5539.0" y="571.0"/> <end x="5602.999" y="986.9071"/> </arc> <arc class="catalysis" id="modif_5b8aba50-f0b3-4be4-8f92-c71e2d3db392" source="akt1_s_akt1_s459_akt1_akt1_sa306" target="pr_cfb860ce-b5e8-4ea3-885d-a957797df07a"> <start x="5780.0" y="998.0"/> <end x="5602.899" y="991.9061"/> </arc> <arc class="catalysis" id="modif_01b233c6-aaf1-4d00-9134-386ff9147109" source="akt1_s_akt1_s460_akt1_akt1_sa307" target="pr_cfb860ce-b5e8-4ea3-885d-a957797df07a"> <start x="5510.0" y="998.0"/> <end x="5592.901" y="991.7056"/> </arc> <arc class="consumption" id="cons_f65f23ce-f977-429b-b561-4c40da37958d" source="akt1_s_akt1_s741_akt1_akt1_sa305" target="pr_b97f11e4-200a-48f8-bbfc-ddefde05fd7a_p1"> <start x="5556.5" y="1081.6138"/> <next x="5518.0" y="1065.0"/> <end x="5528.7407" y="1079.0"/> </arc> <arc class="consumption" id="cons_9e7265bf-e841-4a97-a74f-fb19baa25380" source="akt1_s_akt1_s290_akt1_akt1_sa308" target="pr_b97f11e4-200a-48f8-bbfc-ddefde05fd7a_p1"> <start x="5367.5" y="988.0"/> <next x="5518.0" y="1065.0"/> <end x="5528.7407" y="1079.0"/> </arc> <arc class="production" id="prod_df3238c7-029c-408f-8b54-fdc988fc12e3" source="pr_b97f11e4-200a-48f8-bbfc-ddefde05fd7a_p2" target="akt1_s_akt1_s462_akt1_akt1_csa52"> <start x="5528.7407" y="1109.0"/> <end x="5538.0" y="1119.0"/> </arc> <arc class="consumption" id="cons_acbc56f2-cfe3-4343-b2bd-2965b2e8f559" source="akt1_s_akt1_s465_akt1_akt1_sa311" target="pr_296706c7-5a20-40f3-87eb-826469701e53_p1"> <start x="5692.0" y="1077.4021"/> <next x="5658.75" y="1097.0"/> <end x="5616.591" y="1189.5"/> </arc> <arc class="consumption" id="cons_74d5b41d-d7f4-481f-a4a4-5e1a3bd98e58" source="akt1_s_akt1_s741_akt1_akt1_sa305" target="pr_296706c7-5a20-40f3-87eb-826469701e53_p1"> <start x="5636.5" y="1081.6138"/> <next x="5658.75" y="1097.0"/> <end x="5616.591" y="1189.5"/> </arc> <arc class="production" id="prod_ac2ba3f0-f628-4317-9f8f-a40daf2ddba4" source="pr_296706c7-5a20-40f3-87eb-826469701e53_p2" target="akt1_s_akt1_s467_akt1_akt1_csa53"> <start x="5616.591" y="1219.5"/> <end x="5576.0" y="1308.0"/> </arc> <arc class="consumption" id="addreact_da58f8e4-cb3d-4b5c-bede-a1d10f8b7387" source="akt1_s_akt1_s466_akt1_akt1_sa312" target="pr_296706c7-5a20-40f3-87eb-826469701e53_p1"> <start x="5784.0" y="1077.4021"/> <end x="5616.591" y="1189.5"/> </arc> <arc class="consumption" id="cons_9d043313-297e-4090-81e1-881cf7102607" source="akt1_s_akt1_s471_akt1_akt1_sa316" target="pr_70063ad8-47ff-41da-9ee0-2c40eb1803f4_p1"> <start x="5100.0" y="1199.0"/> <end x="5100.0" y="1195.0"/> </arc> <arc class="production" id="prod_52f1b762-5523-4ba3-8539-3533d8c414f2" source="pr_70063ad8-47ff-41da-9ee0-2c40eb1803f4_p2" target="akt1_s_akt1_s473_akt1_akt1_sa317"> <start x="5100.0" y="1165.0"/> <end x="5100.0" y="1161.0"/> </arc> <arc class="catalysis" id="modif_8ab1159b-24f5-4110-9bcc-68f75f73ce88" source="akt1_s_akt1_s474_akt1_akt1_sa318" target="pr_70063ad8-47ff-41da-9ee0-2c40eb1803f4"> <start x="5178.75" y="1212.0"/> <end x="5105.0" y="1180.0"/> </arc> <arc class="consumption" id="cons_dbd95b0b-13e3-46c1-ac26-cd9ebc02e950" source="akt1_s_akt1_s429_akt1_akt1_sa280" target="pr_dd65b2ed-4124-4f9b-83b4-cb110c379e0b_p1"> <start x="4873.875" y="942.0"/> <end x="5031.3125" y="1067.0"/> </arc> <arc class="production" id="prod_0317ec70-8565-452c-ab1e-f50a06ffb918" source="pr_dd65b2ed-4124-4f9b-83b4-cb110c379e0b_p2" target="akt1_s_akt1_s474_akt1_akt1_sa318"> <start x="5061.3125" y="1067.0"/> <end x="5218.75" y="1192.0"/> </arc> <arc class="consumption" id="cons_18d99ed6-0da3-4bb1-a731-79c8bf247ff9" source="akt1_s_akt1_s473_akt1_akt1_sa317" target="pr_af0a9bed-5788-46a6-9978-def06b67560b_p1"> <start x="5100.0" y="1121.0"/> <end x="5106.0" y="1122.5"/> </arc> <arc class="production" id="prod_1e3440cf-ce9e-4717-a45c-9ab41044bc79" source="pr_af0a9bed-5788-46a6-9978-def06b67560b_p2" target="akt1_s_akt1_s477_akt1_akt1_sa319"> <start x="5106.0" y="1092.5"/> <end x="5112.0" y="1094.0"/> </arc> <arc class="catalysis" id="modif_a03cafae-c1a8-4cc0-aa2b-7667e4a27b9c" source="akt1_s_akt1_s478_akt1_akt1_sa320" target="pr_af0a9bed-5788-46a6-9978-def06b67560b"> <start x="5352.5" y="1108.0"/> <end x="5110.569" y="1109.5306"/> </arc> <arc class="consumption" id="cons_fb08463d-0f9d-4f6f-a7fa-e74a55210567" source="akt1_s_akt1_s477_akt1_akt1_sa319" target="pr_29696afa-e793-4b7f-88a2-a720de07cad1_p1"> <start x="5192.0" y="1094.0"/> <next x="5189.0" y="1131.0"/> <end x="5189.0" y="1136.7693"/> </arc> <arc class="consumption" id="cons_dca7fcc9-873a-4eee-bc6c-10846d504fd0" source="akt1_s_akt1_s290_akt1_akt1_sa308" target="pr_29696afa-e793-4b7f-88a2-a720de07cad1_p1"> <start x="5287.5" y="988.0"/> <next x="5189.0" y="1131.0"/> <end x="5189.0" y="1136.7693"/> </arc> <arc class="production" id="prod_5d5a89d4-11ad-4d93-bfd6-a97d40b50d21" source="pr_29696afa-e793-4b7f-88a2-a720de07cad1_p2" target="akt1_s_akt1_s479_akt1_akt1_csa54"> <start x="5219.0" y="1136.7693"/> <end x="5215.0" y="1141.0"/> </arc> <arc class="consumption" id="cons_4e67d671-9886-44a7-a39e-e37aecf6438c" source="akt1_s_akt1_s479_akt1_akt1_csa54" target="pr_c6342a74-ceef-4bea-a68a-3b250a8a5d58_p1"> <start x="5265.0" y="1051.0"/> <end x="5363.75" y="999.0"/> </arc> <arc class="production" id="prod_a65b9930-dd27-4e68-bdab-9f03e621c457" source="pr_c6342a74-ceef-4bea-a68a-3b250a8a5d58_p2" target="akt1_s_akt1_s713_akt1_akt1_csa55"> <start x="5393.75" y="999.0"/> <end x="5492.5" y="947.0"/> </arc> <arc class="consumption" id="cons_fbd6ab1c-7925-4a13-b174-04727416bb7e" source="akt1_s_akt1_s866_akt1_akt1_csa14" target="pr_94f75e88-b38e-4e31-9efe-b45d69024262_p1"> <start x="5539.0" y="571.0"/> <end x="5465.75" y="814.5"/> </arc> <arc class="production" id="prod_d7b0d8d2-15e1-432e-8363-1c782421610f" source="pr_94f75e88-b38e-4e31-9efe-b45d69024262_p2" target="akt1_s_akt1_s478_akt1_akt1_sa320"> <start x="5465.75" y="844.5"/> <end x="5392.5" y="1088.0"/> </arc> <arc class="consumption" id="cons_66857e5e-af69-4f39-99aa-fd86ca08d267" source="akt1_s_akt1_s485_akt1_akt1_sa325" target="pr_62123742-f386-42ae-9dbf-a6a3a722b7f0_p1"> <start x="5073.0" y="1277.0"/> <end x="5079.0" y="1277.0"/> </arc> <arc class="production" id="prod_67931ccb-7d9c-47ff-8eaf-e069a56b6267" source="pr_62123742-f386-42ae-9dbf-a6a3a722b7f0_p2" target="akt1_s_akt1_s486_akt1_akt1_sa326"> <start x="5109.0" y="1277.0"/> <end x="5115.0" y="1277.0"/> </arc> <arc class="catalysis" id="modif_4dc887ed-fd4f-473a-a1ef-9c85c61a5400" source="akt1_s_akt1_s471_akt1_akt1_sa316" target="pr_62123742-f386-42ae-9dbf-a6a3a722b7f0"> <start x="5100.0" y="1239.0"/> <end x="5094.0" y="1272.0"/> </arc> <arc class="consumption" id="cons_ea80a9da-19c4-449c-a9b2-28516b10c562" source="akt1_s_akt1_s486_akt1_akt1_sa326" target="pr_5f861ffe-999a-4377-8f9e-fcfacb9c3ab7_p1"> <start x="5205.0" y="1277.0"/> <end x="5347.75" y="1277.0"/> </arc> <arc class="production" id="prod_bc28322c-9cd8-4094-b8d9-246dfb2c5e1b" source="pr_5f861ffe-999a-4377-8f9e-fcfacb9c3ab7_p2" target="akt1_s_akt1_s448_akt1_akt1_sa297"> <start x="5377.75" y="1277.0"/> <end x="5520.5" y="1277.0"/> </arc> <arc class="consumption" id="cons_b2b7f009-fd5a-449e-836f-ec35ada9cbd5" source="akt1_s_akt1_s93_akt1_akt1_sa327" target="pr_b968dc20-6c64-45a4-aa56-28c1cf673b6c_p1"> <start x="5598.125" y="1666.1561"/> <end x="5645.5312" y="1710.5781"/> </arc> <arc class="production" id="prod_c09d08fa-ff31-4793-b2f3-7f1ee5dde570" source="pr_b968dc20-6c64-45a4-aa56-28c1cf673b6c_p2" target="akt1_s_akt1_s494_akt1_akt1_sa133"> <start x="5675.5312" y="1710.5781"/> <end x="5722.9375" y="1755.0"/> </arc> <arc class="catalysis" id="modif_923cc141-f8ee-483e-9454-23069917aa57" source="akt1_s_akt1_s297_akt1_akt1_sa208" target="pr_b968dc20-6c64-45a4-aa56-28c1cf673b6c"> <start x="4981.0" y="1770.0"/> <end x="5657.632" y="1714.6515"/> </arc> <arc class="consumption" id="cons_caa90d8e-1528-4e5c-a71b-043a0381d53e" source="akt1_s_akt1_s177_akt1_akt1_sa140" target="pr_497c0619-a7f0-4646-bc48-b86314fb9dc8_p1"> <start x="5734.0" y="1555.0"/> <next x="5698.5" y="1605.5"/> <end x="5772.3735" y="1681.5"/> </arc> <arc class="consumption" id="cons_a6fa5f78-a306-4ce9-affd-5402f1ac015a" source="akt1_s_akt1_s171_akt1_akt1_sa135" target="pr_497c0619-a7f0-4646-bc48-b86314fb9dc8_p1"> <start x="5565.0625" y="1562.0"/> <next x="5698.5" y="1605.5"/> <end x="5772.3735" y="1681.5"/> </arc> <arc class="production" id="prod_d49527e1-3746-4630-bdee-b3a978733b97" source="pr_497c0619-a7f0-4646-bc48-b86314fb9dc8_p2" target="akt1_s_akt1_s878_akt1_akt1_csa57"> <start x="5772.3735" y="1711.5"/> <end x="5843.0" y="1783.5"/> </arc> <arc class="consumption" id="addreact_a638e21f-f5b0-4a7f-8b7c-085a3366b1bb" source="akt1_s_akt1_s170_akt1_akt1_sa134" target="pr_497c0619-a7f0-4646-bc48-b86314fb9dc8_p1"> <start x="5687.875" y="1680.53"/> <end x="5772.3735" y="1681.5"/> </arc> <arc class="consumption" id="addreact_51b053cd-f8c9-46c7-b758-4dc90fc392c9" source="akt1_s_akt1_s494_akt1_akt1_sa133" target="pr_497c0619-a7f0-4646-bc48-b86314fb9dc8_p1"> <start x="5722.9375" y="1755.0"/> <end x="5772.3735" y="1681.5"/> </arc> <arc class="consumption" id="addreact_b06fa735-8e1b-423f-99d5-8e707896dd87" source="akt1_s_akt1_s785_akt1_akt1_sa517" target="pr_497c0619-a7f0-4646-bc48-b86314fb9dc8_p1"> <start x="5622.0" y="1760.0"/> <end x="5772.3735" y="1681.5"/> </arc> <arc class="consumption" id="cons_5ec178c4-619a-4424-b7b4-439f034048a7" source="akt1_s_akt1_s177_akt1_akt1_sa140" target="pr_bf98526d-d4ba-40b9-9a34-893bb816b50d_p1"> <start x="5734.0" y="1555.0"/> <next x="5516.25" y="1669.9485"/> <end x="5493.875" y="1703.2566"/> </arc> <arc class="consumption" id="cons_2a2d330e-dd3d-4013-b455-105142bcc70a" source="akt1_s_akt1_s171_akt1_akt1_sa135" target="pr_bf98526d-d4ba-40b9-9a34-893bb816b50d_p1"> <start x="5565.0625" y="1562.0"/> <next x="5516.25" y="1669.9485"/> <end x="5493.875" y="1703.2566"/> </arc> <arc class="production" id="prod_f201795f-a825-447f-ba1f-0aaf4c8a21bf" source="pr_bf98526d-d4ba-40b9-9a34-893bb816b50d_p2" target="akt1_s_akt1_s873_akt1_akt1_csa84"> <start x="5463.875" y="1703.2566"/> <end x="5445.5" y="1733.0"/> </arc> <arc class="consumption" id="addreact_b62818d7-a2a6-415d-ace4-c5de94ac39b8" source="akt1_s_akt1_s170_akt1_akt1_sa134" target="pr_bf98526d-d4ba-40b9-9a34-893bb816b50d_p1"> <start x="5772.875" y="1680.53"/> <end x="5493.875" y="1703.2566"/> </arc> <arc class="consumption" id="addreact_7271ed36-871c-449e-9cdb-0e6e074bb810" source="akt1_s_akt1_s93_akt1_akt1_sa327" target="pr_bf98526d-d4ba-40b9-9a34-893bb816b50d_p1"> <start x="5598.125" y="1666.1561"/> <end x="5493.875" y="1703.2566"/> </arc> <arc class="consumption" id="addreact_84ff1e8f-a1bd-4883-bcd4-c1333e257dc0" source="akt1_s_akt1_s785_akt1_akt1_sa517" target="pr_bf98526d-d4ba-40b9-9a34-893bb816b50d_p1"> <start x="5588.998" y="1760.0"/> <end x="5493.875" y="1703.2566"/> </arc> <arc class="consumption" id="cons_d8d6d6c6-7b8d-4236-9b1f-ce86d5c78898" source="akt1_s_akt1_s499_akt1_akt1_sa336" target="pr_06701cc3-0232-493c-b2de-f3f030594177_p1"> <start x="6054.0" y="381.0"/> <end x="6055.75" y="381.0"/> </arc> <arc class="production" id="prod_4131d1c0-7066-4a54-ad63-67e064a55908" source="pr_06701cc3-0232-493c-b2de-f3f030594177_p2" target="akt1_s_akt1_s501_akt1_akt1_sa337"> <start x="6085.75" y="381.0"/> <end x="6087.5" y="381.0"/> </arc> <arc class="catalysis" id="modif_74a594eb-8b78-4ae7-a127-382dc512c51e" source="akt1_s_akt1_s866_akt1_akt1_csa14" target="pr_06701cc3-0232-493c-b2de-f3f030594177"> <start x="5614.0" y="543.0"/> <end x="6070.75" y="376.0"/> </arc> <arc class="catalysis" id="modif_05edd421-2782-4621-a27c-72102391aad5" source="akt1_s_akt1_s297_akt1_akt1_sa208" target="pr_06701cc3-0232-493c-b2de-f3f030594177"> <start x="4981.0" y="1780.0"/> <end x="6065.75" y="386.0"/> </arc> <arc class="consumption" id="cons_7b8cc652-2edb-4e90-ab42-38c0f702265a" source="akt1_s_akt1_s22_akt1_akt1_sa13" target="pr_ec44a390-e815-400c-bf85-321c8dfc619d_p1"> <start x="5488.0" y="161.0"/> <end x="5514.5" y="161.0"/> </arc> <arc class="production" id="prod_c91afb0c-f987-460a-bcd5-deaf8e34a4cd" source="pr_ec44a390-e815-400c-bf85-321c8dfc619d_p2" target="akt1_s_akt1_s502_akt1_akt1_sa338"> <start x="5544.5" y="161.0"/> <end x="5571.0" y="161.0"/> </arc> <arc class="catalysis" id="modif_9c74a5ed-f164-48d6-a01a-f9f5b798c373" source="akt1_s_akt1_s503_akt1_akt1_sa339" target="pr_ec44a390-e815-400c-bf85-321c8dfc619d"> <start x="5802.0" y="654.0"/> <end x="5534.5" y="166.0"/> </arc> <arc class="consumption" id="cons_978afe7e-ff9c-45f0-8012-8bd3fe9844b1" source="akt1_s_akt1_s866_akt1_akt1_csa14" target="pr_c9dd76b6-010e-4cdd-84e5-892e95d03723_p1"> <start x="5539.0" y="459.0"/> <end x="5537.5" y="394.75"/> </arc> <arc class="production" id="prod_81857b16-3a63-4454-85cc-774c4b3cbe09" source="pr_c9dd76b6-010e-4cdd-84e5-892e95d03723_p2" target="akt1_s_akt1_s867_akt1_akt1_csa13"> <start x="5537.5" y="364.75"/> <end x="5536.0" y="300.5"/> </arc> <arc class="catalysis" id="modif_5eb99453-06ac-42e5-9c84-8e72ecaaa810" source="akt1_s_akt1_s504_akt1_akt1_sa340" target="pr_c9dd76b6-010e-4cdd-84e5-892e95d03723"> <start x="5723.0" y="774.0"/> <end x="5532.501" y="379.84464"/> </arc> <arc class="consumption" id="cons_b3e1d9cc-ee58-4192-a4fb-811528645b3d" source="akt1_s_akt1_s205_akt1_akt1_sa156" target="pr_f8a1a8e5-7aff-4ddc-b18a-a23fc34826ae_p1"> <start x="5372.5" y="630.0"/> <next x="5298.25" y="498.5"/> <end x="5308.508" y="500.9375"/> </arc> <arc class="consumption" id="cons_fe4ad2c6-e2d0-4b46-a68e-cebf32a95d56" source="akt1_s_akt1_s862_akt1_akt1_csa16" target="pr_f8a1a8e5-7aff-4ddc-b18a-a23fc34826ae_p1"> <start x="5281.8335" y="498.875"/> <next x="5298.25" y="498.5"/> <end x="5308.508" y="500.9375"/> </arc> <arc class="production" id="prod_34be5629-3b71-45c3-98ee-8892fbb9fd56" source="pr_f8a1a8e5-7aff-4ddc-b18a-a23fc34826ae_p2" target="akt1_s_akt1_s863_akt1_akt1_csa58"> <start x="5308.508" y="470.9375"/> <end x="5315.5" y="477.375"/> </arc> <arc class="consumption" id="cons_73fa25ef-b7ce-4872-afe0-072c522fe66c" source="akt1_s_akt1_s516_akt1_akt1_sa347" target="pr_81d266b9-ba66-4a50-a86d-373a509a39e3_p1"> <start x="4990.0" y="985.0"/> <end x="4976.5" y="985.0"/> </arc> <arc class="production" id="prod_3be2ed8a-9ccc-448b-bc35-21c930df4d2e" source="pr_81d266b9-ba66-4a50-a86d-373a509a39e3_p2" target="akt1_s_akt1_s515_akt1_akt1_sa348"> <start x="4946.5" y="985.0"/> <end x="4933.0" y="985.0"/> </arc> <arc class="catalysis" id="modif_d60af3eb-45d2-40d1-89c2-a2bf09f391a1" source="akt1_s_akt1_s866_akt1_akt1_csa14" target="pr_81d266b9-ba66-4a50-a86d-373a509a39e3"> <start x="5514.0" y="487.0"/> <end x="4961.5" y="980.0"/> </arc> <arc class="consumption" id="cons_0cc075ef-c5f9-4a3e-bc40-32445d296caf" source="akt1_s_akt1_s517_akt1_akt1_sa349" target="pr_e5776425-d273-492d-b86d-aafc5e87ab65_p1"> <start x="5229.5" y="1404.0"/> <end x="5229.5" y="1410.0"/> </arc> <arc class="production" id="prod_525b3856-5a84-45d8-a160-486536d7f9a0" source="pr_e5776425-d273-492d-b86d-aafc5e87ab65_p2" target="akt1_s_akt1_s519_akt1_akt1_sa350"> <start x="5229.5" y="1440.0"/> <end x="5229.5" y="1446.0"/> </arc> <arc class="catalysis" id="modif_ae41fb35-feab-4d94-b7c5-8d76fb5718c0" source="akt1_s_akt1_s478_akt1_akt1_sa320" target="pr_e5776425-d273-492d-b86d-aafc5e87ab65"> <start x="5372.5" y="1128.0"/> <end x="5234.5" y="1420.0"/> </arc> <arc class="consumption" id="cons_3890d750-20ee-4456-83a1-5961bb3f26f6" source="akt1_s_akt1_s515_akt1_akt1_sa348" target="pr_8ef3b96a-d40e-4667-a605-8b7661dd839e_p1"> <start x="4893.0" y="1005.0"/> <end x="5061.25" y="1169.5"/> </arc> <arc class="production" id="prod_93ba3961-3ecc-489d-ba55-eeebf202bf36" source="pr_8ef3b96a-d40e-4667-a605-8b7661dd839e_p2" target="akt1_s_akt1_s517_akt1_akt1_sa349"> <start x="5061.25" y="1199.5"/> <end x="5229.5" y="1364.0"/> </arc> <arc class="consumption" id="cons_8f10ec01-e7ae-43cf-a522-b2a8cb7a8dae" source="akt1_s_akt1_s533_akt1_akt1_csa59" target="pr_dca281c7-28fb-403c-af28-e0320a56a2da_p1"> <start x="6606.0" y="828.0"/> <end x="6606.0" y="825.5"/> </arc> <arc class="production" id="prod_3e14af16-cd1c-4d76-812a-192e86c3ad7e" source="pr_dca281c7-28fb-403c-af28-e0320a56a2da_p2" target="akt1_s_akt1_s524_akt1_akt1_sa353"> <start x="6606.0" y="855.5"/> <end x="6606.0" y="853.0"/> </arc> <arc class="consumption" id="cons_3519c0e9-63ac-459a-b108-807d64e78287" source="akt1_s_akt1_s533_akt1_akt1_csa59" target="pr_b20cb6c2-c0f9-4c4a-a96a-cf73b89dae30_p1"> <start x="6656.0" y="769.0"/> <end x="6649.25" y="767.0"/> </arc> <arc class="production" id="prod_a58ba0f2-a076-4f4a-acca-db2802abb9e6" source="pr_b20cb6c2-c0f9-4c4a-a96a-cf73b89dae30_p2" target="akt1_s_akt1_s528_akt1_akt1_csa60"> <start x="6679.25" y="767.0"/> <end x="6672.5" y="765.0"/> </arc> <arc class="catalysis" id="modif_b33cc496-fb91-4ab0-835b-a24d3e863db6" source="akt1_s_akt1_s866_akt1_akt1_csa14" target="pr_b20cb6c2-c0f9-4c4a-a96a-cf73b89dae30"> <start x="5614.0" y="571.0"/> <end x="6663.072" y="762.14075"/> </arc> <arc class="consumption" id="cons_ca52ae96-d6b3-45d6-9413-a784ade70a71" source="akt1_s_akt1_s290_akt1_akt1_sa356" target="pr_379a6f52-f432-449f-a3b5-79b0e18b8463_p1"> <start x="6453.5" y="671.0"/> <end x="6558.5" y="760.0"/> </arc> <arc class="production" id="prod_4dd9d7fc-f566-453e-ab8f-83dcd735c4e2" source="pr_379a6f52-f432-449f-a3b5-79b0e18b8463_p2" target="akt1_s_akt1_s538_akt1_akt1_sa357"> <start x="6588.5" y="760.0"/> <end x="6693.5" y="849.0"/> </arc> <arc class="consumption" id="cons_2cb13000-78d5-490d-903a-3290f3afc93e" source="akt1_s_akt1_s528_akt1_akt1_csa60" target="pr_fa8b1b5f-b50e-4ebf-9a96-cded37732192_p1"> <start x="6672.5" y="824.0"/> <next x="6670.5" y="862.375"/> <end x="6679.658" y="863.1875"/> </arc> <arc class="consumption" id="cons_bdbf26cc-5d20-47be-af64-3cad414bb39f" source="akt1_s_akt1_s538_akt1_akt1_sa357" target="pr_fa8b1b5f-b50e-4ebf-9a96-cded37732192_p1"> <start x="6693.5" y="859.0"/> <next x="6670.5" y="862.375"/> <end x="6679.658" y="863.1875"/> </arc> <arc class="production" id="prod_46e67dbb-25e7-4219-968f-be992b4ffba6" source="pr_fa8b1b5f-b50e-4ebf-9a96-cded37732192_p2" target="akt1_s_akt1_s539_akt1_akt1_csa61"> <start x="6679.658" y="893.1875"/> <end x="6686.5" y="890.0"/> </arc> <arc class="consumption" id="cons_efb2ff85-428d-467a-9dea-b7b610c3353b" source="akt1_s_akt1_s539_akt1_akt1_csa61" target="pr_572ea306-b98d-452c-b420-6f8ef21c3021_p1"> <start x="6660.0" y="977.0"/> <end x="6663.75" y="979.25"/> </arc> <arc class="production" id="prod_814acc60-ebec-4a0b-92d6-a9741019695e" source="pr_572ea306-b98d-452c-b420-6f8ef21c3021_p2" target="akt1_s_akt1_s547_akt1_akt1_csa62"> <start x="6633.75" y="979.25"/> <end x="6637.5" y="981.5"/> </arc> <arc class="catalysis" id="modif_40eb0919-f585-4509-8d02-dd3ec49a2fe6" source="akt1_s_akt1_s866_akt1_akt1_csa14" target="pr_572ea306-b98d-452c-b420-6f8ef21c3021"> <start x="5614.0" y="571.0"/> <end x="6647.7695" y="974.3471"/> </arc> <arc class="consumption" id="cons_7f4a7c2c-5904-4f30-88a0-83385f0eaea5" source="akt1_s_akt1_s547_akt1_akt1_csa62" target="pr_52e548a2-ab70-4d63-9709-b8a64c9067ea_p1"> <start x="6528.5" y="898.5"/> <end x="6530.75" y="885.96606"/> </arc> <arc class="production" id="prod_5748e0d2-d5ce-4abd-89d4-0c1d25719864" source="pr_52e548a2-ab70-4d63-9709-b8a64c9067ea_p2" target="akt1_s_akt1_s560_akt1_akt1_csa63"> <start x="6500.75" y="885.96606"/> <next x="6503.0" y="873.4322"/> <end x="6471.0" y="910.0"/> </arc> <arc class="production" id="prod_a97723d2-0db3-4491-84ec-11add59fd421" source="pr_52e548a2-ab70-4d63-9709-b8a64c9067ea_p2" target="akt1_s_akt1_s558_akt1_akt1_sa366"> <start x="6500.75" y="885.96606"/> <next x="6503.0" y="873.4322"/> <end x="6478.5" y="814.0"/> </arc> <arc class="consumption" id="cons_14498fbe-1057-4989-8ee2-2c96b5cf49bb" source="akt1_s_akt1_s560_akt1_akt1_csa63" target="pr_578d072e-d740-4634-a235-9b0d4c6ef9ba_p1"> <start x="6417.0" y="910.0"/> <end x="6417.25" y="919.0"/> </arc> <arc class="production" id="prod_29dfd884-3471-481d-9f0a-eb2cd74a032b" source="pr_578d072e-d740-4634-a235-9b0d4c6ef9ba_p2" target="akt1_s_akt1_s561_akt1_akt1_csa64"> <start x="6387.25" y="919.0"/> <end x="6387.5" y="928.0"/> </arc> <arc class="consumption" id="cons_2b1cf4e9-7ad4-4e6f-9427-dcfd11168ffa" source="akt1_s_akt1_s564_akt1_akt1_sa370" target="pr_9e451660-3b20-418d-8827-ad8497f817a5_p1"> <start x="6223.0" y="423.5"/> <end x="6223.0" y="428.0"/> </arc> <arc class="production" id="prod_14bbf52d-7066-4267-9f9b-5def12cea1be" source="pr_9e451660-3b20-418d-8827-ad8497f817a5_p2" target="akt1_s_akt1_s565_akt1_akt1_sa371"> <start x="6223.0" y="458.0"/> <end x="6223.0" y="462.5"/> </arc> <arc class="catalysis" id="modif_017aeee6-5662-4975-b03b-2b082b028b4d" source="akt1_s_akt1_s866_akt1_akt1_csa14" target="pr_9e451660-3b20-418d-8827-ad8497f817a5"> <start x="5614.0" y="515.0"/> <end x="6218.0" y="443.0"/> </arc> <arc class="consumption" id="cons_77f52225-069b-4947-af07-4add862ac41a" source="akt1_s_akt1_s565_akt1_akt1_sa371" target="pr_88c0c3e0-d499-49fb-9aa7-5c5dbbbbd74c_p1"> <start x="6263.0" y="482.5"/> <end x="6289.0" y="482.625"/> </arc> <arc class="production" id="prod_5e5fb6d2-f9bc-468b-a581-c6fee79ee518" source="pr_88c0c3e0-d499-49fb-9aa7-5c5dbbbbd74c_p2" target="akt1_s_akt1_s566_akt1_akt1_sa372"> <start x="6319.0" y="482.625"/> <end x="6345.0" y="482.75"/> </arc> <arc class="consumption" id="cons_b1e5f32d-a20d-40d8-903b-c3c6fc926f52" source="akt1_s_akt1_s558_akt1_akt1_sa366" target="pr_9d0ba892-1c84-444a-98af-9f189925b340_p1"> <start x="6478.5" y="774.0"/> <end x="6478.25" y="772.0"/> </arc> <arc class="production" id="prod_d545ad5c-fbdb-47e8-883f-1c77ad96b0c0" source="pr_9d0ba892-1c84-444a-98af-9f189925b340_p2" target="akt1_s_akt1_s567_akt1_akt1_sa373"> <start x="6478.25" y="742.0"/> <end x="6478.0" y="740.0"/> </arc> <arc class="consumption" id="cons_f42477d1-989c-40de-ace7-d26f85133298" source="akt1_s_akt1_s568_akt1_akt1_sa374" target="pr_fa5e165d-912d-4c75-adb9-c692253b8206_p1"> <start x="6166.0" y="847.0"/> <end x="6162.5" y="847.0"/> </arc> <arc class="production" id="prod_5127851a-9506-4695-b9d7-1665cb620b48" source="pr_fa5e165d-912d-4c75-adb9-c692253b8206_p2" target="akt1_s_akt1_s570_akt1_akt1_sa376"> <start x="6192.5" y="847.0"/> <end x="6189.0" y="847.0"/> </arc> <arc class="catalysis" id="modif_ac1d0711-3262-48b9-8d91-6a57a9a241a0" source="akt1_s_akt1_s875_akt1_akt1_csa65" target="pr_fa5e165d-912d-4c75-adb9-c692253b8206"> <start x="6177.0" y="908.0"/> <end x="6177.5" y="852.0"/> </arc> <arc class="consumption" id="cons_398a82fb-dd3a-48e6-a420-1946c39fabd7" source="akt1_s_akt1_s568_akt1_akt1_sa374" target="pr_ba9253ca-21c1-4a54-9c37-865dca0e2c7e_p1"> <start x="6126.0" y="827.0"/> <end x="6185.75" y="787.5"/> </arc> <arc class="production" id="prod_9895f321-23e5-471e-b7f2-4af83ceba7fe" source="pr_ba9253ca-21c1-4a54-9c37-865dca0e2c7e_p2" target="akt1_s_akt1_s569_akt1_akt1_sa375"> <start x="6215.75" y="787.5"/> <end x="6275.5" y="748.0"/> </arc> <arc class="catalysis" id="modif_4a7437e3-80a8-4f8d-8b71-4a047909a114" source="akt1_s_akt1_s866_akt1_akt1_csa14" target="pr_ba9253ca-21c1-4a54-9c37-865dca0e2c7e"> <start x="5614.0" y="515.0"/> <end x="6203.086" y="791.9207"/> </arc> <arc class="consumption" id="cons_f9ebc29a-d611-449b-9992-a3a2dd13ec0e" source="akt1_s_akt1_s582_akt1_akt1_csa67" target="pr_5d8e40bc-911b-4c5d-af10-7089fc436beb_p1"> <start x="6641.5" y="591.0"/> <end x="6503.75" y="682.0"/> </arc> <arc class="production" id="prod_d6f1c235-f9cd-4f12-ba08-42731a3196d6" source="pr_5d8e40bc-911b-4c5d-af10-7089fc436beb_p2" target="akt1_s_akt1_s592_akt1_akt1_sa393"> <start x="6473.75" y="682.0"/> <end x="6336.0" y="773.0"/> </arc> <arc class="catalysis" id="logicarc_d75e18da-aa65-4c8a-af18-1755dcdb89d8" source="logicglyph_37b44088-a37b-418e-ab66-c167262475c3_p2" target="pr_5d8e40bc-911b-4c5d-af10-7089fc436beb"> <start x="6190.75" y="735.5"/> <end x="6481.8955" y="680.2635"/> </arc> <arc class="logic arc" id="modif_39439148-fa28-4ebe-99d3-85c60630b7ab" source="akt1_s_akt1_s722_akt1_akt1_sa478" target="logicglyph_37b44088-a37b-418e-ab66-c167262475c3_p1"> <start x="6129.0" y="608.0"/> <end x="6150.75" y="735.5"/> </arc> <arc class="logic arc" id="modif_27b79e8f-e3ce-4817-91e1-57776ac82498" source="akt1_s_akt1_s723_akt1_akt1_sa479" target="logicglyph_37b44088-a37b-418e-ab66-c167262475c3_p1"> <start x="6131.0" y="659.0"/> <end x="6150.75" y="735.5"/> </arc> <arc class="logic arc" id="modif_ba52c418-bdb8-417d-a154-0e093c879d4f" source="akt1_s_akt1_s624_akt1_akt1_sa425" target="logicglyph_37b44088-a37b-418e-ab66-c167262475c3_p1"> <start x="5880.0" y="1037.0"/> <end x="6150.75" y="735.5"/> </arc> <arc class="consumption" id="cons_286db1da-48f4-4cf2-8b59-3784d8ee4fbc" source="akt1_s_akt1_s579_akt1_akt1_csa66" target="pr_d8f60db8-9000-4464-a5fc-25687f8d261a_p1"> <start x="6553.25" y="344.5"/> <end x="6444.625" y="543.75"/> </arc> <arc class="production" id="prod_04ca9fe4-12d0-48cb-8d31-11410a378cb2" source="pr_d8f60db8-9000-4464-a5fc-25687f8d261a_p2" target="akt1_s_akt1_s592_akt1_akt1_sa393"> <start x="6444.625" y="573.75"/> <end x="6336.0" y="773.0"/> </arc> <arc class="catalysis" id="logicarc_4fa64ebc-ed7d-4340-a89a-778c4565ddbc" source="logicglyph_a0d2c798-b869-4f13-b1f8-bfe1dae0542a_p2" target="pr_d8f60db8-9000-4464-a5fc-25687f8d261a"> <start x="6061.0" y="711.75"/> <end x="6440.1655" y="556.489"/> </arc> <arc class="logic arc" id="modif_629b7cc9-cf98-4d03-82bc-c18044c7cec6" source="akt1_s_akt1_s722_akt1_akt1_sa478" target="logicglyph_a0d2c798-b869-4f13-b1f8-bfe1dae0542a_p1"> <start x="6129.0" y="608.0"/> <end x="6021.0" y="711.75"/> </arc> <arc class="logic arc" id="modif_f021d732-9b12-4e64-bcca-d4f97088ef5f" source="akt1_s_akt1_s723_akt1_akt1_sa479" target="logicglyph_a0d2c798-b869-4f13-b1f8-bfe1dae0542a_p1"> <start x="6131.0" y="659.0"/> <end x="6021.0" y="711.75"/> </arc> <arc class="logic arc" id="modif_7801de11-a88e-41bf-b4e0-8591272abfdb" source="akt1_s_akt1_s624_akt1_akt1_sa425" target="logicglyph_a0d2c798-b869-4f13-b1f8-bfe1dae0542a_p1"> <start x="5880.0" y="1037.0"/> <end x="6021.0" y="711.75"/> </arc> <arc class="consumption" id="cons_3f7ecbf7-10f3-4a88-a270-eba71dfe3114" source="akt1_s_akt1_s6_akt1_akt1_csa1" target="pr_e7f2d0cb-2827-440c-8f69-964845a4eae6_p1"> <start x="4774.0" y="315.0"/> <end x="5622.375" y="286.0"/> </arc> <arc class="production" id="prod_6ce5abab-8200-48a5-853b-cafcd025c70a" source="pr_e7f2d0cb-2827-440c-8f69-964845a4eae6_p2" target="akt1_s_akt1_s579_akt1_akt1_csa66"> <start x="5652.375" y="286.0"/> <end x="6500.75" y="257.0"/> </arc> <arc class="consumption" id="cons_46741785-3b3c-4c90-a07f-666bbd41a7b4" source="akt1_s_akt1_s42_akt1_akt1_csa10" target="pr_2e041e5c-d761-4d91-b289-f4c9959ffdd7_p1"> <start x="5901.0" y="261.0"/> <end x="6185.75" y="368.0"/> </arc> <arc class="production" id="prod_d689ccf1-7746-46f2-948d-ac85fe4dc5ca" source="pr_2e041e5c-d761-4d91-b289-f4c9959ffdd7_p2" target="akt1_s_akt1_s582_akt1_akt1_csa67"> <start x="6215.75" y="368.0"/> <end x="6500.5" y="475.0"/> </arc> <arc class="consumption" id="cons_34d99f89-bd47-45cf-9113-1da8cede4674" source="akt1_s_akt1_s40_akt1_akt1_sa398" target="pr_680f3ad9-da89-45ef-99c7-a570bb1d30ca_p1"> <start x="6258.5" y="550.0"/> <end x="6292.75" y="549.5"/> </arc> <arc class="production" id="prod_56b2fc0c-fbd5-49e2-8daf-80744fbc0d69" source="pr_680f3ad9-da89-45ef-99c7-a570bb1d30ca_p2" target="akt1_s_akt1_s602_akt1_akt1_sa41"> <start x="6322.75" y="549.5"/> <end x="6357.0" y="549.0"/> </arc> <arc class="catalysis" id="modif_7d1786dc-bcd3-4148-b885-c4f4d1527359" source="akt1_s_akt1_s603_akt1_akt1_sa399" target="pr_680f3ad9-da89-45ef-99c7-a570bb1d30ca"> <start x="6308.0" y="597.0"/> <end x="6307.801" y="554.49976"/> </arc> <arc class="consumption" id="cons_3f60f74f-7d04-4bef-acc0-a530127d59dc" source="akt1_s_akt1_s35_akt1_akt1_sa55" target="pr_61785acd-8f0f-4330-9bf9-51b870ffc063_p1"> <start x="5308.75" y="782.0"/> <end x="5317.125" y="826.5"/> </arc> <arc class="production" id="prod_6b9461ab-b4ea-48e8-9020-8dbdc689e49b" source="pr_61785acd-8f0f-4330-9bf9-51b870ffc063_p2" target="akt1_s_akt1_s609_akt1_akt1_sa400"> <start x="5317.125" y="856.5"/> <end x="5325.5" y="901.0"/> </arc> <arc class="catalysis" id="modif_59c4bd23-cabe-4030-80bd-5ac3ae00e7b4" source="akt1_s_akt1_s135_akt1_akt1_sa109" target="pr_61785acd-8f0f-4330-9bf9-51b870ffc063"> <start x="5535.0" y="672.0"/> <end x="5322.076" y="840.8031"/> </arc> <arc class="consumption" id="cons_53c7bd76-9a5f-4a04-9626-0a05d8d063af" source="akt1_s_akt1_s114_akt1_akt1_sa62" target="pr_4b55ef54-be05-405e-8ec4-42af90d36ea7_p1"> <start x="4950.5" y="1092.0"/> <end x="4967.5137" y="1127.6111"/> </arc> <arc class="production" id="prod_a10731c9-d849-4b4b-8050-dfaaba5f2df8" source="pr_4b55ef54-be05-405e-8ec4-42af90d36ea7_p2" target="akt1_s_akt1_s118_akt1_akt1_sa94"> <start x="4967.5137" y="1157.6111"/> <end x="4984.528" y="1193.2222"/> </arc> <arc class="consumption" id="cons_28212c95-5ac8-482d-8a59-cc40d6d099e7" source="akt1_s_akt1_s116_akt1_akt1_sa92" target="pr_a1ccd50d-fc88-4dad-b49f-8e081fd86951_p1"> <start x="5055.5" y="1091.0"/> <end x="5020.0137" y="1127.1111"/> </arc> <arc class="production" id="prod_425f3df3-baf2-4127-8dae-5b4482376e85" source="pr_a1ccd50d-fc88-4dad-b49f-8e081fd86951_p2" target="akt1_s_akt1_s118_akt1_akt1_sa94"> <start x="5020.0137" y="1157.1111"/> <end x="4984.528" y="1193.2222"/> </arc> <arc class="consumption" id="cons_f02ebc55-08cc-4a07-b0ab-729f078484b9" source="akt1_s_akt1_s118_akt1_akt1_sa94" target="pr_a741082e-2bdc-4014-ad53-769c03f1b3d1_p1"> <start x="4944.528" y="1223.2222"/> <end x="4897.0137" y="1351.1111"/> </arc> <arc class="production" id="prod_228e1028-bdcf-4b1b-880a-b7f01dd6f1e1" source="pr_a741082e-2bdc-4014-ad53-769c03f1b3d1_p2" target="akt1_s_akt1_s35_akt1_akt1_sa406"> <start x="4897.0137" y="1381.1111"/> <end x="4849.5" y="1509.0"/> </arc> <arc class="consumption" id="cons_a10fd524-b347-40f5-a394-ac90b0317265" source="akt1_s_akt1_s615_akt1_akt1_sa413" target="pr_2d7c674e-f0a7-446e-8809-2f21fb10c12f_p1"> <start x="6037.5" y="754.0"/> <end x="6065.0" y="754.0"/> </arc> <arc class="production" id="prod_f6a91662-4283-4ae4-a606-f5e5db09b7d1" source="pr_2d7c674e-f0a7-446e-8809-2f21fb10c12f_p2" target="akt1_s_akt1_s616_akt1_akt1_sa414"> <start x="6095.0" y="754.0"/> <end x="6122.5" y="754.0"/> </arc> <arc class="catalysis" id="logicarc_92603eb8-45c4-48a2-a9c0-3a1b33ff3991" source="logicglyph_6d6cb4a6-997b-4bb7-bf33-6a611457d8fe_p2" target="pr_2d7c674e-f0a7-446e-8809-2f21fb10c12f"> <start x="5990.25" y="650.005"/> <end x="6080.0" y="759.0"/> </arc> <arc class="logic arc" id="modif_a0c48bb6-c09d-486f-a2ef-5c9133983d20" source="akt1_s_akt1_s874_akt1_akt1_csa70" target="logicglyph_6d6cb4a6-997b-4bb7-bf33-6a611457d8fe_p1"> <start x="5777.0" y="835.0"/> <end x="5990.25" y="610.005"/> </arc> <arc class="logic arc" id="modif_ca6d5a19-8556-4c3b-bf06-faa261ac8f39" source="akt1_s_akt1_s624_akt1_akt1_sa425" target="logicglyph_6d6cb4a6-997b-4bb7-bf33-6a611457d8fe_p1"> <start x="5880.0" y="1037.0"/> <end x="5990.25" y="610.005"/> </arc> <arc class="logic arc" id="modif_7836de11-b763-474f-9895-5f33de32da2a" source="akt1_s_akt1_s623_akt1_akt1_sa424" target="logicglyph_6d6cb4a6-997b-4bb7-bf33-6a611457d8fe_p1"> <start x="5971.0" y="1037.0"/> <end x="5990.25" y="610.005"/> </arc> <arc class="consumption" id="cons_5d8f4a74-cf66-478c-83a4-16e3442a3d7b" source="akt1_s_akt1_s504_akt1_akt1_sa340" target="pr_d22f47af-5195-47d3-8c8d-25176953c476_p1"> <start x="5763.0" y="754.0"/> <end x="5767.875" y="754.0"/> </arc> <arc class="production" id="prod_33249424-0f69-4eb7-a28c-9bf625ceb772" source="pr_d22f47af-5195-47d3-8c8d-25176953c476_p2" target="akt1_s_akt1_s617_akt1_akt1_sa415"> <start x="5797.875" y="754.0"/> <end x="5802.75" y="754.0"/> </arc> <arc class="catalysis" id="modif_2544ed0a-e694-4094-9475-1ff17e1010c2" source="akt1_s_akt1_s367_akt1_akt1_sa241" target="pr_d22f47af-5195-47d3-8c8d-25176953c476"> <start x="5199.0" y="1734.0"/> <end x="5782.875" y="759.0"/> </arc> <arc class="consumption" id="cons_32b4a743-5cfc-42c1-ae74-9f1e67fe0aba" source="akt1_s_akt1_s617_akt1_akt1_sa415" target="pr_9e474693-08a8-46b4-a736-98e6c3ce4ed2_p1"> <start x="5882.75" y="754.0"/> <end x="5905.125" y="754.0"/> </arc> <arc class="production" id="prod_acf7deed-cc83-4e68-af49-c655ee8175c5" source="pr_9e474693-08a8-46b4-a736-98e6c3ce4ed2_p2" target="akt1_s_akt1_s615_akt1_akt1_sa413"> <start x="5935.125" y="754.0"/> <end x="5957.5" y="754.0"/> </arc> <arc class="catalysis" id="modif_78572341-cbb0-4036-ba6c-2850ebcc4f1a" source="akt1_s_akt1_s499_akt1_akt1_sa336" target="pr_9e474693-08a8-46b4-a736-98e6c3ce4ed2"> <start x="6014.0" y="401.0"/> <end x="5920.125" y="749.0"/> </arc> <arc class="consumption" id="cons_6346029e-8ef8-4885-8b54-9d83e9fa4e0c" source="akt1_s_akt1_s625_akt1_akt1_sa426" target="pr_a3e542d9-b1e3-44d8-96e3-87da65d8f90d_p1"> <start x="4992.0" y="1439.0"/> <end x="5003.0" y="1439.0"/> </arc> <arc class="production" id="prod_898e3b85-dcda-4dda-9686-f7fad830a234" source="pr_a3e542d9-b1e3-44d8-96e3-87da65d8f90d_p2" target="akt1_s_akt1_s626_akt1_akt1_sa427"> <start x="5033.0" y="1439.0"/> <end x="5044.0" y="1439.0"/> </arc> <arc class="catalysis" id="modif_087760d6-54e0-4526-bea5-ed5c69ae8578" source="akt1_s_akt1_s871_akt1_akt1_csa46" target="pr_a3e542d9-b1e3-44d8-96e3-87da65d8f90d"> <start x="4826.5" y="2019.0"/> <end x="5018.0" y="1444.0"/> </arc> <arc class="consumption" id="cons_205b7c5b-a4cd-4b9f-9cf9-3d0e15f2c4a8" source="akt1_s_akt1_s626_akt1_akt1_sa427" target="pr_8d246134-d47b-439c-9cea-441097b079a5_p1"> <start x="5132.4307" y="1426.5"/> <end x="5417.7153" y="1115.25"/> </arc> <arc class="production" id="prod_8f094cff-82b7-422b-8adc-1100ca2efade" source="pr_8d246134-d47b-439c-9cea-441097b079a5_p2" target="akt1_s_akt1_s504_akt1_akt1_sa340"> <start x="5417.7153" y="1085.25"/> <end x="5703.0" y="774.0"/> </arc> <arc class="consumption" id="cons_5ac2231d-6b29-40d6-8f71-efdc77f24987" source="akt1_s_akt1_s289_akt1_akt1_csa37" target="pr_fc0e36ac-036c-40fe-9864-89cad55ea0b0_p1"> <start x="5989.0" y="2236.0"/> <end x="5977.25" y="2283.75"/> </arc> <arc class="production" id="prod_5890031f-c1df-4bb0-8294-127969a5f8cf" source="pr_fc0e36ac-036c-40fe-9864-89cad55ea0b0_p2" target="akt1_s_akt1_s595_akt1_akt1_csa68"> <start x="5977.25" y="2313.75"/> <end x="5965.5" y="2361.5"/> </arc> <arc class="consumption" id="cons_3f2caa45-b865-4856-b0dc-5226cc8ba0f3" source="akt1_s_akt1_s640_akt1_akt1_csa71" target="pr_6faba24b-d620-48e3-a426-ceae4fdce7c2_p1"> <start x="6658.0" y="1395.5"/> <end x="6670.0" y="1399.0"/> </arc> <arc class="production" id="prod_38d541bd-be3e-446d-99cc-c2f56876986d" source="pr_6faba24b-d620-48e3-a426-ceae4fdce7c2_p2" target="akt1_s_akt1_s642_akt1_akt1_csa72"> <start x="6700.0" y="1399.0"/> <end x="6712.0" y="1402.5"/> </arc> <arc class="consumption" id="cons_c69b0f3b-243a-4f9a-8f4d-3ecc6e99fd71" source="akt1_s_akt1_s634_akt1_akt1_sa123" target="pr_09bded0f-76c2-444d-bf0d-35baf07eae56_p1"> <start x="6603.722" y="1293.5555"/> <next x="6641.722" y="1314.7778"/> <end x="6637.1113" y="1324.3668"/> </arc> <arc class="consumption" id="cons_baad1f78-d6c7-4d42-b8ea-67430ef85aa3" source="akt1_s_akt1_s290_akt1_akt1_sa429" target="pr_09bded0f-76c2-444d-bf0d-35baf07eae56_p1"> <start x="6721.8823" y="1296.0"/> <next x="6641.722" y="1314.7778"/> <end x="6637.1113" y="1324.3668"/> </arc> <arc class="production" id="prod_78659dcc-1ad5-460f-87bc-72ebacb198de" source="pr_09bded0f-76c2-444d-bf0d-35baf07eae56_p2" target="akt1_s_akt1_s640_akt1_akt1_csa71"> <start x="6607.1113" y="1324.3668"/> <end x="6606.5" y="1332.0"/> </arc> <arc class="consumption" id="cons_cb10c8bc-0a48-42c7-9c62-d5196ca9b77a" source="akt1_s_akt1_s159_akt1_akt1_sa121" target="pr_86e61fa7-af9c-4b94-b3f7-c3f71d48b13a_p1"> <start x="6190.222" y="1302.5354"/> <end x="6157.5522" y="1280.9148"/> </arc> <arc class="production" id="prod_dbe84591-33cd-400f-8073-f9212f0c1724" source="pr_86e61fa7-af9c-4b94-b3f7-c3f71d48b13a_p2" target="akt1_s_akt1_s648_akt1_akt1_sa434"> <start x="6157.5522" y="1250.9148"/> <end x="6124.8823" y="1229.2941"/> </arc> <arc class="catalysis" id="modif_c6664132-f6fb-4176-bbcf-873d7f174e4b" source="akt1_s_akt1_s649_akt1_akt1_sa435" target="pr_86e61fa7-af9c-4b94-b3f7-c3f71d48b13a"> <start x="6159.0" y="1120.0"/> <end x="6161.283" y="1262.5863"/> </arc> <arc class="consumption" id="cons_50860731-8975-4ed9-afe6-6720a0635f21" source="akt1_s_akt1_s159_akt1_akt1_sa121" target="pr_6f32f130-225a-4776-a429-7d5b7b102927_p1"> <start x="6190.222" y="1302.5354"/> <end x="6171.5522" y="1302.2677"/> </arc> <arc class="production" id="prod_df4eb3c7-2a91-4479-a46a-e97a847cd854" source="pr_6f32f130-225a-4776-a429-7d5b7b102927_p2" target="akt1_s_akt1_s651_akt1_akt1_sa436"> <start x="6141.5522" y="1302.2677"/> <end x="6122.8823" y="1302.0"/> </arc> <arc class="catalysis" id="modif_455d90fe-8da6-4cc7-a6a2-50fb2b31d86f" source="akt1_s_akt1_s652_akt1_akt1_sa437" target="pr_6f32f130-225a-4776-a429-7d5b7b102927"> <start x="5954.0" y="1158.0"/> <end x="6156.592" y="1297.2678"/> </arc> <arc class="consumption" id="cons_53bfd4cf-b077-4a41-a95e-80ebab289690" source="akt1_s_akt1_s290_akt1_akt1_sa439" target="pr_846b0ca2-b6b2-4c5e-81d6-05951e09407f_p1"> <start x="5171.5" y="611.5"/> <end x="5075.0" y="509.25"/> </arc> <arc class="production" id="prod_2a75bbd0-d087-4ca1-a2ef-e86d75715331" source="pr_846b0ca2-b6b2-4c5e-81d6-05951e09407f_p2" target="akt1_s_akt1_s676_akt1_akt1_sa291"> <start x="5075.0" y="479.25"/> <end x="4978.5" y="377.0"/> </arc> <arc class="consumption" id="cons_9a754b52-491a-45cd-af00-5019912f260e" source="akt1_s_akt1_s860_akt1_akt1_csa51" target="pr_226643fb-64ed-48f4-81fa-fc20b6caa3ca_p1"> <start x="4674.5" y="494.875"/> <end x="4653.0" y="486.6875"/> </arc> <arc class="production" id="prod_b6597070-a1c0-482e-832a-dae91a4b0575" source="pr_226643fb-64ed-48f4-81fa-fc20b6caa3ca_p2" target="akt1_s_akt1_s859_akt1_akt1_csa73"> <start x="4623.0" y="486.6875"/> <end x="4601.5" y="478.5"/> </arc> <arc class="consumption" id="cons_4abb355f-bbd2-4fd7-b08d-5bf977a86733" source="akt1_s_akt1_s864_akt1_akt1_csa74" target="pr_1118b70b-00c0-42da-80e6-a887a66c3b74_p1"> <start x="4603.5" y="652.5"/> <end x="4837.667" y="613.9375"/> </arc> <arc class="production" id="prod_f237c221-f519-4712-80ea-673aeddff666" source="pr_1118b70b-00c0-42da-80e6-a887a66c3b74_p2" target="akt1_s_akt1_s862_akt1_akt1_csa16"> <start x="4867.667" y="613.9375"/> <end x="5101.8335" y="575.375"/> </arc> <arc class="catalysis" id="modif_b421d808-a5bb-4d8d-a4ef-ed915afbe38f" source="akt1_s_akt1_s670_akt1_akt1_sa451" target="pr_1118b70b-00c0-42da-80e6-a887a66c3b74"> <start x="4863.0" y="373.5"/> <end x="4851.9023" y="608.99634"/> </arc> <arc class="consumption" id="cons_c95ddd03-d0a5-429a-bda1-ccc89ce46c21" source="akt1_s_akt1_s674_akt1_akt1_sa455" target="pr_87fc2750-cb1a-4976-b58e-dbf034b2a38b_p1"> <start x="4616.5" y="353.5"/> <end x="4704.75" y="353.5"/> </arc> <arc class="production" id="prod_d1b55b7f-43c9-4106-939b-852f6e6357d6" source="pr_87fc2750-cb1a-4976-b58e-dbf034b2a38b_p2" target="akt1_s_akt1_s670_akt1_akt1_sa451"> <start x="4734.75" y="353.5"/> <end x="4823.0" y="353.5"/> </arc> <arc class="catalysis" id="modif_faf603b2-f248-4d1e-bec8-17b6d9706446" source="akt1_s_akt1_s653_akt1_akt1_sa438" target="pr_87fc2750-cb1a-4976-b58e-dbf034b2a38b"> <start x="4760.0" y="360.0"/> <end x="4719.75" y="348.5"/> </arc> <arc class="consumption" id="cons_3c1dcc8b-61ac-4268-90d3-8c876688523d" source="akt1_s_akt1_s570_akt1_akt1_sa376" target="pr_82402bcd-6806-4031-bd62-573bbb8299da_p1"> <start x="6269.0" y="837.0"/> <end x="6402.5" y="852.5"/> </arc> <arc class="production" id="prod_a5c02858-7e3a-47cd-8f61-be279bc5f356" source="pr_82402bcd-6806-4031-bd62-573bbb8299da_p2" target="akt1_s_akt1_s524_akt1_akt1_sa353"> <start x="6432.5" y="852.5"/> <end x="6566.0" y="868.0"/> </arc> <arc class="consumption" id="cons_376fe9ec-c47e-477e-a480-eb7a56cf361d" source="akt1_s_akt1_s714_akt1_akt1_sa471" target="pr_2fcc6320-b2e7-48cb-83c6-6d1bc7768826_p1"> <start x="6423.5" y="1080.0"/> <end x="6277.0" y="1069.0"/> </arc> <arc class="production" id="prod_c74fca1e-bf78-4970-805f-a1e5b0fbb165" source="pr_2fcc6320-b2e7-48cb-83c6-6d1bc7768826_p2" target="akt1_s_akt1_s715_akt1_akt1_sa472"> <start x="6247.0" y="1069.0"/> <end x="6100.5" y="1058.0"/> </arc> <arc class="catalysis" id="modif_6a096bd3-8dae-44fd-bc74-1df92fe58419" source="akt1_s_akt1_s716_akt1_akt1_sa473" target="pr_2fcc6320-b2e7-48cb-83c6-6d1bc7768826"> <start x="6638.0" y="1091.0"/> <end x="6266.6484" y="1074.3282"/> </arc> <arc class="consumption" id="cons_4d4cb02b-0d15-4f10-88fd-f62c6d0f2a81" source="akt1_s_akt1_s721_akt1_akt1_sa477" target="pr_ed573d86-5ddc-47ab-b66e-4f319542e1ef_p1"> <start x="6013.5" y="870.0"/> <next x="6045.0" y="917.5"/> <end x="6066.1597" y="928.0"/> </arc> <arc class="consumption" id="cons_5a5023a8-77a2-42ec-a6e6-49d48400aeb9" source="akt1_s_akt1_s718_akt1_akt1_csa75" target="pr_ed573d86-5ddc-47ab-b66e-4f319542e1ef_p1"> <start x="6021.0" y="964.0"/> <next x="6045.0" y="917.5"/> <end x="6066.1597" y="928.0"/> </arc> <arc class="production" id="prod_3cdfa47a-16a6-441b-acd1-b1a7bf8b8f48" source="pr_ed573d86-5ddc-47ab-b66e-4f319542e1ef_p2" target="akt1_s_akt1_s875_akt1_akt1_csa65"> <start x="6066.1597" y="958.0"/> <end x="6084.0" y="964.5"/> </arc> <arc class="consumption" id="addreact_2e51b109-3944-4526-97d5-6b8f415e6465" source="akt1_s_akt1_s715_akt1_akt1_sa472" target="pr_ed573d86-5ddc-47ab-b66e-4f319542e1ef_p1"> <start x="6060.5" y="1038.0"/> <end x="6066.1597" y="928.0"/> </arc> <arc class="consumption" id="cons_4f4eb4c3-64fc-44fd-8cb1-34409aeb0c6e" source="akt1_s_akt1_s155_akt1_akt1_csa22" target="pr_008aa880-1103-497b-8ca5-a15fc55f12c4_p1"> <start x="5750.0" y="1114.0"/> <end x="6015.5" y="958.5"/> </arc> <arc class="production" id="prod_2a24e42e-0f69-4cf1-8e9d-143313945f85" source="pr_008aa880-1103-497b-8ca5-a15fc55f12c4_p2" target="akt1_s_akt1_s592_akt1_akt1_sa393"> <start x="6045.5" y="958.5"/> <end x="6311.0" y="803.0"/> </arc> <arc class="catalysis" id="logicarc_71f94ead-0588-4f7e-88d7-f21e9a444fb7" source="logicglyph_ca4d9fd6-14b2-4456-87d5-904718ee152c_p2" target="pr_008aa880-1103-497b-8ca5-a15fc55f12c4"> <start x="5957.0" y="1020.33325"/> <end x="6028.5513" y="965.29724"/> </arc> <arc class="logic arc" id="modif_4a2974c9-4fdb-4b05-9258-367f3032f8e9" source="akt1_s_akt1_s624_akt1_akt1_sa425" target="logicglyph_ca4d9fd6-14b2-4456-87d5-904718ee152c_p1"> <start x="5900.0" y="1077.0"/> <end x="5957.0" y="1060.3333"/> </arc> <arc class="logic arc" id="modif_c367e89f-d4e6-4f63-945d-ae81846976a4" source="akt1_s_akt1_s623_akt1_akt1_sa424" target="logicglyph_ca4d9fd6-14b2-4456-87d5-904718ee152c_p1"> <start x="5951.0" y="1077.0"/> <end x="5957.0" y="1060.3333"/> </arc> <arc class="consumption" id="cons_6318b26d-acdf-4e12-ac87-dd8b75431fdb" source="akt1_s_akt1_s724_akt1_akt1_csa76" target="pr_8a5c5102-8585-42f1-8aa8-a285a7a6c0d4_p1"> <start x="5747.0" y="1248.0"/> <end x="6020.25" y="1025.5"/> </arc> <arc class="production" id="prod_fab6c9fd-8875-4de0-8399-aea86eff9708" source="pr_8a5c5102-8585-42f1-8aa8-a285a7a6c0d4_p2" target="akt1_s_akt1_s592_akt1_akt1_sa393"> <start x="6050.25" y="1025.5"/> <end x="6323.5" y="803.0"/> </arc> <arc class="catalysis" id="logicarc_ce149399-3440-4a56-849b-1f1b92a5c4b0" source="logicglyph_f742ebf3-0c35-46c6-9e22-1c64873b8622_p2" target="pr_8a5c5102-8585-42f1-8aa8-a285a7a6c0d4"> <start x="5974.3335" y="1058.3333"/> <end x="6032.195" y="1021.542"/> </arc> <arc class="logic arc" id="modif_8481c7a8-8a69-44b6-b9fa-8e84ef1b1af8" source="akt1_s_akt1_s624_akt1_akt1_sa425" target="logicglyph_f742ebf3-0c35-46c6-9e22-1c64873b8622_p1"> <start x="5880.0" y="1077.0"/> <end x="5934.3335" y="1058.3333"/> </arc> <arc class="logic arc" id="modif_bfc4473a-812b-444e-a572-00a8dc95a5fb" source="akt1_s_akt1_s623_akt1_akt1_sa424" target="logicglyph_f742ebf3-0c35-46c6-9e22-1c64873b8622_p1"> <start x="5951.0" y="1077.0"/> <end x="5934.3335" y="1058.3333"/> </arc> <arc class="consumption" id="cons_de4da90e-f768-4815-9795-0935fe421d3c" source="akt1_s_akt1_s725_akt1_akt1_csa77" target="pr_ff4b854a-5c9d-4a21-944a-afab5c8866cb_p1"> <start x="5747.0" y="1378.0"/> <end x="6026.5" y="1090.5"/> </arc> <arc class="production" id="prod_b150340d-d7ca-4623-adff-71c495a6b6d3" source="pr_ff4b854a-5c9d-4a21-944a-afab5c8866cb_p2" target="akt1_s_akt1_s592_akt1_akt1_sa393"> <start x="6056.5" y="1090.5"/> <end x="6336.0" y="803.0"/> </arc> <arc class="catalysis" id="logicarc_78bfbf5d-c919-4e5b-9609-12035caaf37d" source="logicglyph_52ad000e-fd1f-4d92-90d3-752ca0d1df89_p2" target="pr_ff4b854a-5c9d-4a21-944a-afab5c8866cb"> <start x="5976.3335" y="1081.0"/> <end x="6034.4297" y="1090.4149"/> </arc> <arc class="logic arc" id="modif_ee80b654-17c7-49a3-bedc-67253072678d" source="akt1_s_akt1_s624_akt1_akt1_sa425" target="logicglyph_52ad000e-fd1f-4d92-90d3-752ca0d1df89_p1"> <start x="5880.0" y="1077.0"/> <end x="5936.3335" y="1081.0"/> </arc> <arc class="logic arc" id="modif_ab87d377-8ed6-47db-b823-3803ceb747f8" source="akt1_s_akt1_s623_akt1_akt1_sa424" target="logicglyph_52ad000e-fd1f-4d92-90d3-752ca0d1df89_p1"> <start x="5951.0" y="1077.0"/> <end x="5936.3335" y="1081.0"/> </arc> <arc class="consumption" id="cons_0da4646a-2d2c-45e1-8250-d2c0d90f1b9a" source="akt1_s_akt1_s730_akt1_akt1_csa78" target="pr_ae437c92-1aac-4587-8621-9087cb4eb946_p1"> <start x="5902.0" y="1308.0"/> <end x="6125.25" y="1070.5"/> </arc> <arc class="production" id="prod_9581fdc7-ff0a-4fe0-8510-cbf397517b25" source="pr_ae437c92-1aac-4587-8621-9087cb4eb946_p2" target="akt1_s_akt1_s592_akt1_akt1_sa393"> <start x="6125.25" y="1040.5"/> <end x="6348.5" y="803.0"/> </arc> <arc class="catalysis" id="logicarc_bd1042e6-95c7-4cfa-9c1d-558e0a530324" source="logicglyph_90d22503-34d6-46ed-baca-38337a0b26d5_p2" target="pr_ae437c92-1aac-4587-8621-9087cb4eb946"> <start x="6001.6665" y="1076.6666"/> <end x="6118.1924" y="1055.934"/> </arc> <arc class="logic arc" id="modif_59db5725-1a80-4d5e-bc2d-a2c81071db97" source="akt1_s_akt1_s624_akt1_akt1_sa425" target="logicglyph_90d22503-34d6-46ed-baca-38337a0b26d5_p1"> <start x="5880.0" y="1077.0"/> <end x="5961.6665" y="1076.6666"/> </arc> <arc class="logic arc" id="modif_eadad302-9aa8-487a-ab83-a1081245b54b" source="akt1_s_akt1_s623_akt1_akt1_sa424" target="logicglyph_90d22503-34d6-46ed-baca-38337a0b26d5_p1"> <start x="5951.0" y="1077.0"/> <end x="5961.6665" y="1076.6666"/> </arc> <arc class="consumption" id="cons_0815d01d-eeda-4ec6-9d94-dd8c2c1ebbec" source="akt1_s_akt1_s467_akt1_akt1_csa53" target="pr_050df34d-f972-447f-9939-8585fced7949_p1"> <start x="5525.0" y="1388.5"/> <end x="5499.75" y="1389.25"/> </arc> <arc class="production" id="prod_e655727e-0171-4375-b3a2-eec9e7433f58" source="pr_050df34d-f972-447f-9939-8585fced7949_p2" target="akt1_s_akt1_s736_akt1_akt1_csa79"> <start x="5469.75" y="1389.25"/> <end x="5444.5" y="1390.0"/> </arc> <arc class="consumption" id="cons_51587123-949d-4822-9475-881e1de96e8c" source="akt1_s_akt1_s93_akt1_akt1_sa327" target="pr_466b8c77-2e93-42d2-ada7-5171e99290fc_p1"> <start x="5558.125" y="1646.1561"/> <end x="5542.4375" y="1646.1561"/> </arc> <arc class="production" id="prod_54fb0a2a-8b23-43ec-90df-f4a08f601336" source="pr_466b8c77-2e93-42d2-ada7-5171e99290fc_p2" target="akt1_s_akt1_s747_akt1_akt1_sa496"> <start x="5512.4375" y="1646.1561"/> <end x="5496.75" y="1646.1561"/> </arc> <arc class="catalysis" id="logicarc_c054dfdd-c243-4cae-be74-89174eee440a" source="logicglyph_0cb5dc34-9b7b-45b6-929e-6ea4bb87afc9_p2" target="pr_466b8c77-2e93-42d2-ada7-5171e99290fc"> <start x="5584.2188" y="1720.083"/> <end x="5527.4375" y="1651.1561"/> </arc> <arc class="logic arc" id="modif_218894f5-9289-4958-9571-57de6da69b48" source="akt1_s_akt1_s742_akt1_akt1_csa80" target="logicglyph_0cb5dc34-9b7b-45b6-929e-6ea4bb87afc9_p1"> <start x="5688.0" y="1912.0"/> <end x="5584.2188" y="1760.083"/> </arc> <arc class="logic arc" id="modif_072828f2-8c61-4a72-a6ec-73be29a48451" source="akt1_s_akt1_s624_akt1_akt1_sa425" target="logicglyph_0cb5dc34-9b7b-45b6-929e-6ea4bb87afc9_p1"> <start x="5880.0" y="1077.0"/> <end x="5584.2188" y="1760.083"/> </arc> <arc class="logic arc" id="modif_6717c0d6-02d5-4a83-9d04-f20a000b10d7" source="akt1_s_akt1_s623_akt1_akt1_sa424" target="logicglyph_0cb5dc34-9b7b-45b6-929e-6ea4bb87afc9_p1"> <start x="5931.0" y="1067.0"/> <end x="5584.2188" y="1760.083"/> </arc> <arc class="consumption" id="cons_7210f7d7-c1ed-4bcb-b872-d586d979ca99" source="akt1_s_akt1_s751_akt1_akt1_sa499" target="pr_996a596b-866f-4993-b015-06f9749c9b81_p1"> <start x="5350.0" y="2410.0"/> <end x="5367.75" y="2410.0"/> </arc> <arc class="production" id="prod_16ca34ef-fdba-42ea-abd6-39f1fa0df7e8" source="pr_996a596b-866f-4993-b015-06f9749c9b81_p2" target="akt1_s_akt1_s753_akt1_akt1_sa500"> <start x="5397.75" y="2410.0"/> <end x="5415.5" y="2410.0"/> </arc> <arc class="catalysis" id="modif_3436832e-b374-4b9a-a639-989ff487dc99" source="akt1_s_akt1_s866_akt1_akt1_csa14" target="pr_996a596b-866f-4993-b015-06f9749c9b81"> <start x="5564.0" y="571.0"/> <end x="5382.75" y="2405.0"/> </arc> <arc class="consumption" id="cons_92042c27-f645-4d38-aa35-36f7624e6b4c" source="akt1_s_akt1_s754_akt1_akt1_sa501" target="pr_fc53303c-53d8-4748-a948-586907d539ff_p1"> <start x="5659.0" y="2197.0"/> <end x="5659.0" y="2172.0"/> </arc> <arc class="production" id="prod_22cb588b-b044-4821-b412-71d64c59f5d7" source="pr_fc53303c-53d8-4748-a948-586907d539ff_p2" target="akt1_s_akt1_s754_akt1_akt1_sa502"> <start x="5659.0" y="2142.0"/> <end x="5659.0" y="2117.0"/> </arc> <arc class="catalysis" id="modif_7d053e2e-ea40-435d-a30b-670066f03c36" source="akt1_s_akt1_s761_akt1_akt1_sa506" target="pr_fc53303c-53d8-4748-a948-586907d539ff"> <start x="5602.0" y="2156.0"/> <end x="5654.0" y="2157.0"/> </arc> <arc class="catalysis" id="modif_8dc3dc73-c37f-4145-906c-459613fada82" source="akt1_s_akt1_s570_akt1_akt1_sa376" target="pr_fc53303c-53d8-4748-a948-586907d539ff"> <start x="6229.0" y="867.0"/> <end x="5664.0" y="2157.0"/> </arc> <arc class="consumption" id="cons_0bde657c-9c5c-4637-886a-1244dd590799" source="akt1_s_akt1_s753_akt1_akt1_sa500" target="pr_543b693f-ecfd-4b84-ac92-2480fa7ae619_p1"> <start x="5455.5" y="2390.0"/> <end x="5455.5" y="2392.0"/> </arc> <arc class="production" id="prod_b9c2042a-ec99-471c-b952-c6dd6a057f85" source="pr_543b693f-ecfd-4b84-ac92-2480fa7ae619_p2" target="akt1_s_akt1_s760_akt1_akt1_sa505"> <start x="5455.5" y="2362.0"/> <end x="5455.5" y="2364.0"/> </arc> <arc class="catalysis" id="modif_99619a4f-2c34-4179-b832-7e678c569038" source="akt1_s_akt1_s866_akt1_akt1_csa14" target="pr_543b693f-ecfd-4b84-ac92-2480fa7ae619"> <start x="5564.0" y="571.0"/> <end x="5460.5" y="2377.0"/> </arc> <arc class="consumption" id="cons_f1a9ca8b-6ce6-4435-96b2-a552ac2d9c94" source="akt1_s_akt1_s760_akt1_akt1_sa505" target="pr_40713f5d-0c01-47eb-a990-8e96ca00a9f6_p1"> <start x="5495.5" y="2344.0"/> <next x="5585.5" y="2344.0"/> <end x="5611.25" y="2352.9387"/> </arc> <arc class="consumption" id="cons_ca61f9a2-85e4-48ed-bd55-66ec3154d8e2" source="akt1_s_akt1_s754_akt1_akt1_sa501" target="pr_40713f5d-0c01-47eb-a990-8e96ca00a9f6_p1"> <start x="5659.0" y="2237.0"/> <next x="5585.5" y="2344.0"/> <end x="5611.25" y="2352.9387"/> </arc> <arc class="production" id="prod_34f204e9-65a0-4654-a2de-fa1e31068ea5" source="pr_40713f5d-0c01-47eb-a990-8e96ca00a9f6_p2" target="akt1_s_akt1_s755_akt1_akt1_csa82"> <start x="5641.25" y="2352.9387"/> <end x="5663.0" y="2361.0"/> </arc> <arc class="consumption" id="cons_7499e356-d708-4a52-a122-947ee048e107" source="akt1_s_akt1_s754_akt1_akt1_sa502" target="pr_e804445c-5545-4841-ac8e-9061dd0519ce_p1"> <start x="5659.0" y="2077.0"/> <end x="6126.625" y="1495.0"/> </arc> <arc class="production" id="prod_48d11307-fd6f-4c68-96c6-c6ca1860ab7e" source="pr_e804445c-5545-4841-ac8e-9061dd0519ce_p2" target="akt1_s_akt1_s524_akt1_akt1_sa353"> <start x="6126.625" y="1465.0"/> <end x="6594.2505" y="883.0"/> </arc> <arc class="consumption" id="cons_3001e2c1-ed4a-4012-b53a-74f21171506b" source="akt1_s_akt1_s765_akt1_akt1_sa507" target="pr_29448f71-4853-49d4-8404-719ef48e5a8b_p1"> <start x="4505.0" y="2466.0"/> <end x="4532.25" y="2466.0"/> </arc> <arc class="production" id="prod_9a02d108-7c29-4a54-84d4-c3f45389e627" source="pr_29448f71-4853-49d4-8404-719ef48e5a8b_p2" target="akt1_s_akt1_s766_akt1_akt1_sa508"> <start x="4562.25" y="2466.0"/> <end x="4589.5" y="2466.0"/> </arc> <arc class="catalysis" id="modif_3308ec34-cc76-4286-ac4c-43387d097438" source="akt1_s_akt1_s318_akt1_akt1_csa40" target="pr_29448f71-4853-49d4-8404-719ef48e5a8b"> <start x="4820.4688" y="1253.0"/> <end x="4547.25" y="2461.0"/> </arc> <arc class="consumption" id="cons_b448f229-11db-4207-ab1e-7d1a9612ea5a" source="akt1_s_akt1_s766_akt1_akt1_sa508" target="pr_4e7d84a3-1d61-42ce-9352-7103ab2755d5_p1"> <start x="4669.5" y="2466.0"/> <end x="4701.5" y="2466.0"/> </arc> <arc class="production" id="prod_8b005298-f784-44aa-9edd-d51c09523e1b" source="pr_4e7d84a3-1d61-42ce-9352-7103ab2755d5_p2" target="akt1_s_akt1_s767_akt1_akt1_sa509"> <start x="4731.5" y="2466.0"/> <end x="4763.5" y="2466.0"/> </arc> <arc class="catalysis" id="modif_721a6806-a2dd-40cd-ba40-7650701b6f01" source="akt1_s_akt1_s363_akt1_akt1_sa238" target="pr_4e7d84a3-1d61-42ce-9352-7103ab2755d5"> <start x="5248.31" y="1698.0"/> <end x="4716.5" y="2461.0"/> </arc> <arc class="consumption" id="cons_e0d44c63-d232-4716-a83d-37dbae6e3a24" source="akt1_s_akt1_s873_akt1_akt1_csa84" target="pr_5419a8ef-4eab-4083-968b-cea109188c72_p1"> <start x="5542.5" y="1861.0"/> <end x="5779.08" y="1793.0"/> </arc> <arc class="production" id="prod_d551da09-476a-459e-b561-b5353dea9978" source="pr_5419a8ef-4eab-4083-968b-cea109188c72_p2" target="akt1_s_akt1_s879_akt1_akt1_csa24"> <start x="5809.08" y="1793.0"/> <end x="6045.6597" y="1725.0"/> </arc> <arc class="consumption" id="cons_4b620bb2-3ea3-4efb-8fb9-745cf0496f79" source="akt1_s_akt1_s427_akt1_akt1_sa279" target="pr_3a962dc6-724b-4085-b972-e6026ccca2cd_p1"> <start x="4616.75" y="922.0"/> <end x="4605.5" y="922.0"/> </arc> <arc class="production" id="prod_91850379-e823-40c0-9226-3142a062951d" source="pr_3a962dc6-724b-4085-b972-e6026ccca2cd_p2" target="akt1_s_akt1_s817_akt1_akt1_sa536"> <start x="4575.5" y="922.0"/> <end x="4564.25" y="922.0"/> </arc> <arc class="catalysis" id="modif_cec4ed81-bbeb-4f0e-b388-193a7adc6890" source="akt1_s_akt1_s816_akt1_akt1_csa85" target="pr_3a962dc6-724b-4085-b972-e6026ccca2cd"> <start x="4730.0" y="733.0"/> <end x="4590.5" y="917.0"/> </arc> <arc class="consumption" id="cons_cc593c36-7b1b-4963-b6c0-c210a956e324" source="akt1_s_akt1_s816_akt1_akt1_csa85" target="pr_cec1b7c0-ad1c-414d-baee-497bb0a791f2_p1"> <start x="4824.0" y="670.5"/> <end x="4846.25" y="670.5"/> </arc> <arc class="production" id="prod_db478fc7-cbf2-4b14-bc06-2baf0bb06df1" source="pr_cec1b7c0-ad1c-414d-baee-497bb0a791f2_p2" target="akt1_s_akt1_s822_akt1_akt1_csa86"> <start x="4876.25" y="670.5"/> <end x="4898.5" y="670.5"/> </arc> <arc class="catalysis" id="modif_c1573d04-b79a-4206-ad21-eba01fe8faea" source="akt1_s_akt1_s429_akt1_akt1_sa280" target="pr_cec1b7c0-ad1c-414d-baee-497bb0a791f2"> <start x="4913.875" y="902.0"/> <end x="4866.25" y="675.5"/> </arc> <arc class="catalysis" id="modif_013ee29a-f6e8-437b-8cc7-2a48d8fc2392" source="akt1_s_akt1_s767_akt1_akt1_sa509" target="pr_cec1b7c0-ad1c-414d-baee-497bb0a791f2"> <start x="4803.5" y="2446.0"/> <end x="4856.25" y="675.5"/> </arc> <arc class="catalysis" id="modif_a2dc6bb5-1c11-4fa4-9d94-45f405451db6" source="akt1_s_akt1_s297_akt1_akt1_sa208" target="pr_cec1b7c0-ad1c-414d-baee-497bb0a791f2"> <start x="4939.5557" y="1760.0"/> <end x="4861.25" y="675.5"/> </arc> <arc class="catalysis" id="modif_6f8fff4f-7588-4a3d-a7fa-058d13532bd8" source="akt1_s_akt1_s866_akt1_akt1_csa14" target="pr_cec1b7c0-ad1c-414d-baee-497bb0a791f2"> <start x="5564.0" y="571.0"/> <end x="4861.25" y="665.5"/> </arc> <arc class="consumption" id="cons_f8afc4a1-a2fa-495a-85cf-1f916c8dc049" source="akt1_s_akt1_s822_akt1_akt1_csa86" target="pr_9e847226-3539-4565-bd47-75feeb32f440_p1"> <start x="4992.5" y="733.0"/> <end x="4992.2676" y="744.1328"/> </arc> <arc class="production" id="prod_e581bb14-38e6-407b-9d25-523e86439198" source="pr_9e847226-3539-4565-bd47-75feeb32f440_p2" target="akt1_s_akt1_s826_akt1_akt1_sa540"> <start x="4992.2676" y="774.1328"/> <next x="4992.0356" y="785.2656"/> <end x="4891.25" y="806.5"/> </arc> <arc class="production" id="prod_6231f18d-69ff-43be-a6a6-d11d9a47caec" source="pr_9e847226-3539-4565-bd47-75feeb32f440_p2" target="akt1_s_akt1_s827_akt1_akt1_sa541"> <start x="4992.2676" y="774.1328"/> <next x="4992.0356" y="785.2656"/> <end x="5000.5" y="806.5"/> </arc> <arc class="production" id="addprod_bacc2622-6a56-4d1f-b1b3-4ba8f52e8630" source="pr_9e847226-3539-4565-bd47-75feeb32f440_p2" target="akt1_s_akt1_s828_akt1_akt1_sa542"> <start x="4992.2676" y="774.1328"/> <end x="5104.5" y="806.5"/> </arc> <arc class="consumption" id="cons_6bae263e-acad-4bbb-b568-be47c0689f3a" source="akt1_s_akt1_s290_akt1_akt1_sa439" target="pr_0318bc57-ca8d-4495-a889-372ca431b93b_p1"> <start x="5171.5" y="631.5"/> <next x="4759.9375" y="807.0"/> <end x="4726.4688" y="807.0"/> </arc> <arc class="consumption" id="cons_a2301b29-df61-495d-9f72-887dfd03826f" source="akt1_s_akt1_s826_akt1_akt1_sa540" target="pr_0318bc57-ca8d-4495-a889-372ca431b93b_p1"> <start x="4891.25" y="826.5"/> <next x="4759.9375" y="807.0"/> <end x="4726.4688" y="807.0"/> </arc> <arc class="production" id="prod_7e1adbab-bf90-4914-b6d7-846cda234215" source="pr_0318bc57-ca8d-4495-a889-372ca431b93b_p2" target="akt1_s_akt1_s829_akt1_akt1_csa87"> <start x="4696.4688" y="807.0"/> <end x="4667.0" y="807.0"/> </arc> <arc class="consumption" id="cons_85571eec-ee96-4155-94d6-40d324850150" source="akt1_s_akt1_s832_akt1_akt1_sa545" target="pr_57b84356-ef19-492e-a332-ad7c09cbaa2c_p1"> <start x="6422.0" y="2295.0"/> <next x="6521.25" y="2319.0"/> <end x="6528.3125" y="2318.0"/> </arc> <arc class="consumption" id="cons_861bc19a-8bf8-4ad9-8d46-7d75ca998916" source="akt1_s_akt1_s833_akt1_akt1_sa546" target="pr_57b84356-ef19-492e-a332-ad7c09cbaa2c_p1"> <start x="6520.5" y="2295.0"/> <next x="6521.25" y="2319.0"/> <end x="6528.3125" y="2318.0"/> </arc> <arc class="production" id="prod_f878093a-e06e-40e0-ae1d-94523697747e" source="pr_57b84356-ef19-492e-a332-ad7c09cbaa2c_p2" target="akt1_s_akt1_s835_akt1_akt1_csa88"> <start x="6528.3125" y="2348.0"/> <end x="6533.3574" y="2343.0"/> </arc> <arc class="consumption" id="addreact_ecc3602f-e196-4a6b-88c6-0b0cd90fcd6a" source="akt1_s_akt1_s834_akt1_akt1_sa547" target="pr_57b84356-ef19-492e-a332-ad7c09cbaa2c_p1"> <start x="6579.0" y="2310.704"/> <end x="6528.3125" y="2318.0"/> </arc> <arc class="consumption" id="cons_6852b04e-eb75-4362-b474-4f21fbcf4521" source="akt1_s_akt1_s835_akt1_akt1_csa88" target="pr_84a73900-2be8-42e7-bcb6-7ce820308797_p1"> <start x="6593.3574" y="2423.5"/> <end x="6609.1074" y="2423.5"/> </arc> <arc class="production" id="prod_a22416ed-83b7-4b9d-af48-690442cbe3cb" source="pr_84a73900-2be8-42e7-bcb6-7ce820308797_p2" target="akt1_s_akt1_s847_akt1_akt1_csa90"> <start x="6639.1074" y="2423.5"/> <end x="6654.8574" y="2423.5"/> </arc> <arc class="catalysis" id="modif_22ab4a2b-8108-4f93-a948-fe5b99015a48" source="akt1_s_akt1_s883_akt1_akt1_csa32" target="pr_84a73900-2be8-42e7-bcb6-7ce820308797"> <start x="6179.3193" y="2132.5"/> <end x="6624.1074" y="2418.5"/> </arc> <arc class="consumption" id="cons_8cf7b1cb-b333-49bf-881b-2819d3bbfa7a" source="akt1_s_akt1_s835_akt1_akt1_csa88" target="pr_665ce212-36c4-4d76-bd3d-076f0e952ce5_p1"> <start x="6473.3574" y="2423.5"/> <end x="6457.6074" y="2423.5"/> </arc> <arc class="production" id="prod_ddf93ec3-110a-491e-8f10-88fa46dd7a4e" source="pr_665ce212-36c4-4d76-bd3d-076f0e952ce5_p2" target="akt1_s_akt1_s851_akt1_akt1_csa89"> <start x="6427.6074" y="2423.5"/> <end x="6411.8574" y="2423.5"/> </arc> <arc class="consumption" id="cons_c5fe6206-9f69-456d-9802-59e71d6407fc" source="akt1_s_akt1_s851_akt1_akt1_csa89" target="pr_f37e5f65-a626-4373-8538-40147aca4fa3_p1"> <start x="6291.8574" y="2423.5"/> <end x="6261.9287" y="2423.25"/> </arc> <arc class="production" id="prod_d09f9991-0610-43ac-acbb-b0ae5244f2c0" source="pr_f37e5f65-a626-4373-8538-40147aca4fa3_p2" target="akt1_s_akt1_s855_akt1_akt1_sa557"> <start x="6231.9287" y="2423.25"/> <end x="6202.0" y="2423.0"/> </arc> <arc class="consumption" id="cons_e32eb418-8efb-4f07-8788-1a8aa65688d7" source="akt1_s_akt2_s6_akt1_akt2_sa6" target="pr_ac575e0a-e701-49ad-b37c-12bea6d56af4_p1"> <start x="5199.5" y="3037.0"/> <end x="5214.25" y="3037.413"/> </arc> <arc class="production" id="prod_60fcd7ac-8686-4d69-a819-3c1d3dff52f3" source="pr_ac575e0a-e701-49ad-b37c-12bea6d56af4_p2" target="akt1_s_akt2_s7_akt1_akt2_sa7"> <start x="5244.25" y="3037.413"/> <end x="5259.0" y="3037.8264"/> </arc> <arc class="catalysis" id="modif_ef2b39c3-fb46-4585-bcb6-9b5c61d72a98" source="akt1_s_akt2_s195_akt1_akt2_csa25" target="pr_ac575e0a-e701-49ad-b37c-12bea6d56af4"> <start x="4996.5" y="3494.0"/> <end x="5234.18" y="3042.4822"/> </arc> <arc class="catalysis" id="modif_c3bad50f-7bad-4b4e-98a8-c279d9bf49d4" source="akt1_s_akt2_s228_akt1_akt2_csa28" target="pr_ac575e0a-e701-49ad-b37c-12bea6d56af4"> <start x="5008.5" y="3311.5"/> <end x="5229.1807" y="3042.4126"/> </arc> <arc class="catalysis" id="modif_cd7761a9-59c5-42e8-8482-53cdadb66b6b" source="akt1_s_akt2_s435_akt1_akt2_csa1" target="pr_ac575e0a-e701-49ad-b37c-12bea6d56af4"> <start x="5117.0" y="2996.75"/> <end x="5234.319" y="3032.483"/> </arc> <arc class="consumption" id="cons_1264c50f-f3d5-4c00-8dbb-15c3c2f758cc" source="akt1_s_akt2_s435_akt1_akt2_csa1" target="pr_26155b9f-65be-45a4-944e-6768b8e46622_p1"> <start x="5017.0" y="3024.25"/> <end x="5011.375" y="3024.25"/> </arc> <arc class="production" id="prod_c0e044cf-f5a4-4f85-947d-3fa1f899aa7e" source="pr_26155b9f-65be-45a4-944e-6768b8e46622_p2" target="akt1_s_akt2_s436_akt1_akt2_csa2"> <start x="4981.375" y="3024.25"/> <end x="4975.75" y="3024.25"/> </arc> <arc class="catalysis" id="modif_06078f2b-4771-48b9-8e14-afbf09eead10" source="akt1_s_akt2_s13_akt1_akt2_sa14" target="pr_26155b9f-65be-45a4-944e-6768b8e46622"> <start x="4996.5" y="3099.0"/> <end x="4996.375" y="3029.25"/> </arc> <arc class="consumption" id="cons_fbdca29d-97c0-4211-8884-5d484a03cfdf" source="akt1_s_akt2_s11_akt1_akt2_sa12" target="pr_7a5f5c70-7baa-45e7-ac5b-1e1af8f00334_p1"> <start x="5199.5" y="3110.0"/> <end x="5214.25" y="3110.0"/> </arc> <arc class="production" id="prod_9840e03f-790c-4b68-8eec-097fe80d3bb2" source="pr_7a5f5c70-7baa-45e7-ac5b-1e1af8f00334_p2" target="akt1_s_akt2_s12_akt1_akt2_sa13"> <start x="5244.25" y="3110.0"/> <end x="5259.0" y="3110.0"/> </arc> <arc class="catalysis" id="modif_00fed16c-0c63-403d-aa74-8024d9d59bab" source="akt1_s_akt2_s435_akt1_akt2_csa1" target="pr_7a5f5c70-7baa-45e7-ac5b-1e1af8f00334"> <start x="5117.0" y="3051.75"/> <end x="5229.25" y="3105.0"/> </arc> <arc class="consumption" id="cons_41f79ca9-b47e-40e2-8255-5a93d84f7d2c" source="akt1_s_akt2_s436_akt1_akt2_csa2" target="pr_01ab7f87-8f9f-40a8-89a7-6b6a5671d88e_p1"> <start x="4875.75" y="3024.25"/> <end x="4870.125" y="3024.25"/> </arc> <arc class="production" id="prod_392f3bea-01d2-4dbc-bf9d-6be3d3340548" source="pr_01ab7f87-8f9f-40a8-89a7-6b6a5671d88e_p2" target="akt1_s_akt2_s437_akt1_akt2_csa3"> <start x="4840.125" y="3024.25"/> <end x="4834.5" y="3024.25"/> </arc> <arc class="catalysis" id="modif_f61cb6bf-1a7e-46b2-85a0-5f6d54418cf8" source="akt1_s_akt2_s1_akt1_akt2_sa1" target="pr_01ab7f87-8f9f-40a8-89a7-6b6a5671d88e"> <start x="4855.5" y="3099.0"/> <end x="4855.125" y="3029.25"/> </arc> <arc class="consumption" id="cons_285f98f3-1e0d-447b-9ff7-127771852630" source="akt1_s_akt2_s437_akt1_akt2_csa3" target="pr_896a8213-5439-48cd-a94c-4686fd1404e4_p1"> <start x="4809.5" y="3079.25"/> <end x="4809.4443" y="3081.125"/> </arc> <arc class="production" id="prod_3feef554-b318-42ee-b166-3e60809763fe" source="pr_896a8213-5439-48cd-a94c-4686fd1404e4_p2" target="akt1_s_akt2_s21_akt1_akt2_sa17"> <start x="4809.4443" y="3111.125"/> <next x="4809.388" y="3113.0"/> <end x="4862.75" y="3170.5"/> </arc> <arc class="production" id="prod_b829620d-e255-48ed-b785-c831c472f485" source="pr_896a8213-5439-48cd-a94c-4686fd1404e4_p2" target="akt1_s_akt2_s406_akt1_akt2_sa18"> <start x="4809.4443" y="3111.125"/> <next x="4809.388" y="3113.0"/> <end x="4765.25" y="3117.0"/> </arc> <arc class="consumption" id="cons_351de87c-eadc-49cf-866b-3bea6881d01f" source="akt1_s_akt2_s23_akt1_akt2_sa19" target="pr_486bdbf6-58d9-480c-9f81-c0b378a0a8fd_p1"> <start x="4519.0" y="3061.0"/> <end x="4592.25" y="3125.75"/> </arc> <arc class="production" id="prod_28beeb3f-d737-4f50-869d-cf79899b7984" source="pr_486bdbf6-58d9-480c-9f81-c0b378a0a8fd_p2" target="akt1_s_akt2_s24_akt1_akt2_sa20"> <start x="4622.25" y="3125.75"/> <end x="4695.5" y="3190.5"/> </arc> <arc class="consumption" id="cons_afbe9763-14c2-467b-abd6-2f05e9ada6e0" source="akt1_s_akt2_s21_akt1_akt2_sa17" target="pr_cc3dd208-aa16-49a0-919a-be501b586af9_p1"> <start x="4822.75" y="3190.5"/> <next x="4801.0" y="3190.5"/> <end x="4801.0" y="3213.25"/> </arc> <arc class="consumption" id="cons_5476be4e-ef1a-4f32-bd30-7841c7ce6a2a" source="akt1_s_akt2_s24_akt1_akt2_sa20" target="pr_cc3dd208-aa16-49a0-919a-be501b586af9_p1"> <start x="4775.5" y="3190.5"/> <next x="4801.0" y="3190.5"/> <end x="4801.0" y="3213.25"/> </arc> <arc class="production" id="prod_d42bf7e1-5250-45a8-a50d-be67d89383f1" source="pr_cc3dd208-aa16-49a0-919a-be501b586af9_p2" target="akt1_s_akt2_s25_akt1_akt2_csa4"> <start x="4801.0" y="3243.25"/> <end x="4801.0" y="3262.0"/> </arc> <arc class="consumption" id="cons_39dbd66f-485b-42cf-961f-b1b3101e33a9" source="akt1_s_akt2_s25_akt1_akt2_csa4" target="pr_96d712bb-78ea-4e12-aa56-aa2b1e1f8846_p1"> <start x="4751.0" y="3322.0"/> <end x="4650.75" y="3257.5"/> </arc> <arc class="production" id="prod_fe79f2fe-452c-463d-a867-cf3a446491b9" source="pr_96d712bb-78ea-4e12-aa56-aa2b1e1f8846_p2" target="akt1_s_akt2_s28_akt1_akt2_csa5"> <start x="4620.75" y="3257.5"/> <end x="4520.5" y="3193.0"/> </arc> <arc class="consumption" id="cons_ac983de2-c006-4eaf-a928-ea48923a71cf" source="akt1_s_akt2_s31_akt1_akt2_sa25" target="pr_506e4d3d-b5a7-4286-ad68-268821fd6f35_p1"> <start x="5199.5" y="3182.0"/> <end x="5214.25" y="3182.0"/> </arc> <arc class="production" id="prod_de1164a2-a009-4af3-9859-c6274f9be8bd" source="pr_506e4d3d-b5a7-4286-ad68-268821fd6f35_p2" target="akt1_s_akt2_s32_akt1_akt2_sa26"> <start x="5244.25" y="3182.0"/> <end x="5259.0" y="3182.0"/> </arc> <arc class="catalysis" id="modif_eb3c6ddd-f19c-4260-bd91-4f6edc6a9725" source="akt1_s_akt2_s435_akt1_akt2_csa1" target="pr_506e4d3d-b5a7-4286-ad68-268821fd6f35"> <start x="5117.0" y="3079.25"/> <end x="5229.25" y="3177.0"/> </arc> <arc class="consumption" id="cons_ba4adac8-23b8-4f9c-bc2d-a15ebd7dd664" source="akt1_s_akt2_s33_akt1_akt2_sa27" target="pr_a3b370c8-9218-4b28-8bf7-5ad5f9d36f1a_p1"> <start x="5199.5" y="3253.0"/> <end x="5214.25" y="3253.0"/> </arc> <arc class="production" id="prod_e3b92aa8-76c4-4c93-985a-e59dec5f8ff0" source="pr_a3b370c8-9218-4b28-8bf7-5ad5f9d36f1a_p2" target="akt1_s_akt2_s34_akt1_akt2_sa28"> <start x="5244.25" y="3253.0"/> <end x="5259.0" y="3253.0"/> </arc> <arc class="catalysis" id="modif_0a107088-9c4a-4317-94de-39321ced9ba1" source="akt1_s_akt2_s435_akt1_akt2_csa1" target="pr_a3b370c8-9218-4b28-8bf7-5ad5f9d36f1a"> <start x="5092.0" y="3079.25"/> <end x="5229.25" y="3248.0"/> </arc> <arc class="catalysis" id="modif_cdd5f0c1-05ba-4ce3-817d-f1f6b5921550" source="akt1_s_akt2_s228_akt1_akt2_csa28" target="pr_a3b370c8-9218-4b28-8bf7-5ad5f9d36f1a"> <start x="5061.0" y="3362.0"/> <end x="5224.25" y="3258.0"/> </arc> <arc class="consumption" id="cons_7c276361-0096-44a8-b354-4bbb6d638683" source="akt1_s_akt2_s35_akt1_akt2_sa29" target="pr_e260afaf-67ff-4407-9ff8-a303909ded9e_p1"> <start x="5199.5" y="3323.0"/> <end x="5214.25" y="3323.0"/> </arc> <arc class="production" id="prod_cc639edb-b908-4534-bdac-37216d58932f" source="pr_e260afaf-67ff-4407-9ff8-a303909ded9e_p2" target="akt1_s_akt2_s36_akt1_akt2_sa30"> <start x="5244.25" y="3323.0"/> <end x="5259.0" y="3323.0"/> </arc> <arc class="catalysis" id="modif_8c317110-32c5-4e3e-84e5-3dc436b29ee9" source="akt1_s_akt2_s435_akt1_akt2_csa1" target="pr_e260afaf-67ff-4407-9ff8-a303909ded9e"> <start x="5067.0" y="3079.25"/> <end x="5229.25" y="3318.0"/> </arc> <arc class="catalysis" id="modif_2a2b544a-0f7a-4c3c-9705-07e1936af3c8" source="akt1_s_akt2_s228_akt1_akt2_csa28" target="pr_e260afaf-67ff-4407-9ff8-a303909ded9e"> <start x="5061.0" y="3362.0"/> <end x="5224.25" y="3328.0"/> </arc> <arc class="consumption" id="cons_135748f5-9507-4da2-a29b-4ac28ce8a995" source="akt1_s_akt2_s38_akt1_akt2_sa32" target="pr_8e0bf40f-ecee-4814-93f0-50bfabeb4bbe_p1"> <start x="5525.0" y="3937.0"/> <end x="5571.375" y="3973.5"/> </arc> <arc class="production" id="prod_98661b24-a2b8-4c58-88d3-f6d034460057" source="pr_8e0bf40f-ecee-4814-93f0-50bfabeb4bbe_p2" target="akt1_s_akt2_s43_akt1_akt2_sa36"> <start x="5571.375" y="4003.5"/> <end x="5617.75" y="4040.0"/> </arc> <arc class="catalysis" id="modif_70f085ca-1ffd-4131-984f-c5c25aa9c707" source="akt1_s_akt2_s42_akt1_akt2_sa37" target="pr_8e0bf40f-ecee-4814-93f0-50bfabeb4bbe"> <start x="5752.0" y="3976.0"/> <end x="5578.4365" y="3988.8699"/> </arc> <arc class="consumption" id="cons_c36fc1d6-0c02-4697-9c4a-2fd758d9b7f9" source="akt1_s_akt2_s39_akt1_akt2_sa33" target="pr_b7ffa04a-c620-4d59-aedd-b03f78d5f63d_p1"> <start x="5696.5" y="3939.0"/> <end x="5657.125" y="3974.5"/> </arc> <arc class="production" id="prod_598f363a-7a15-45e2-b9e5-bf1ae7b84d6c" source="pr_b7ffa04a-c620-4d59-aedd-b03f78d5f63d_p2" target="akt1_s_akt2_s43_akt1_akt2_sa36"> <start x="5657.125" y="4004.5"/> <end x="5617.75" y="4040.0"/> </arc> <arc class="catalysis" id="modif_2e1a29a8-a0eb-47ab-9afb-e6322a2e717c" source="akt1_s_akt2_s42_akt1_akt2_sa37" target="pr_b7ffa04a-c620-4d59-aedd-b03f78d5f63d"> <start x="5752.0" y="3976.0"/> <end x="5661.068" y="3992.5745"/> </arc> <arc class="consumption" id="cons_a071add4-edc2-4787-9f3d-6320855498aa" source="akt1_s_akt2_s43_akt1_akt2_sa36" target="pr_163be7f3-dc7f-4da2-b68e-f17ba70af52c_p1"> <start x="5657.75" y="4060.0"/> <end x="6191.125" y="4008.0"/> </arc> <arc class="production" id="prod_45794719-003c-4f53-a240-540df67eb3c9" source="pr_163be7f3-dc7f-4da2-b68e-f17ba70af52c_p2" target="akt1_s_akt2_s219_akt1_akt2_sa38"> <start x="6221.125" y="4008.0"/> <end x="6754.5" y="3956.0"/> </arc> <arc class="consumption" id="cons_8ddfd0c4-dc3d-415a-9012-d58fdb5a6a8f" source="akt1_s_akt2_s42_akt1_akt2_sa39" target="pr_96fad95f-e8bb-4962-8fe4-b5289d2359e0_p1"> <start x="5792.5" y="4050.0"/> <end x="5792.25" y="4038.0"/> </arc> <arc class="production" id="prod_311d72dc-9190-4058-bbe6-af4b4155deee" source="pr_96fad95f-e8bb-4962-8fe4-b5289d2359e0_p2" target="akt1_s_akt2_s42_akt1_akt2_sa37"> <start x="5792.25" y="4008.0"/> <end x="5792.0" y="3996.0"/> </arc> <arc class="catalysis" id="modif_8c71b283-e7f2-4800-8512-fef080212ae1" source="akt1_s_akt2_s444_akt1_akt2_csa6" target="pr_96fad95f-e8bb-4962-8fe4-b5289d2359e0"> <start x="5790.0" y="4153.0"/> <end x="5787.25" y="4023.0464"/> </arc> <arc class="consumption" id="cons_89da74b9-97ed-48c8-b8aa-521eb9b36d01" source="akt1_s_akt2_s38_akt1_akt2_sa32" target="pr_ea82951a-649f-4cab-9b5c-cae6dd134e3c_p1"> <start x="5525.0" y="3897.0"/> <end x="5554.625" y="3877.0"/> </arc> <arc class="production" id="prod_ae17ae15-c96d-4c4a-bd76-212bbaaa83f4" source="pr_ea82951a-649f-4cab-9b5c-cae6dd134e3c_p2" target="akt1_s_akt2_s46_akt1_akt2_sa41"> <start x="5584.625" y="3877.0"/> <end x="5614.25" y="3857.0"/> </arc> <arc class="consumption" id="cons_a8122b60-11ec-489d-8bde-60209245ce2e" source="akt1_s_akt2_s39_akt1_akt2_sa33" target="pr_17a224a0-a29a-436e-8bd3-a817aeea7847_p1"> <start x="5696.5" y="3899.0"/> <end x="5670.375" y="3878.0"/> </arc> <arc class="production" id="prod_91349881-49cd-4396-984f-a90afab8eac1" source="pr_17a224a0-a29a-436e-8bd3-a817aeea7847_p2" target="akt1_s_akt2_s46_akt1_akt2_sa41"> <start x="5640.375" y="3878.0"/> <end x="5614.25" y="3857.0"/> </arc> <arc class="consumption" id="cons_5f87bdb1-8002-421a-828f-a01f7484832f" source="akt1_s_akt2_s47_akt1_akt2_sa42" target="pr_5e60e04e-939f-455e-8ac6-d46e7ace29e5_p1"> <start x="5199.5" y="3421.0"/> <end x="5214.25" y="3421.0"/> </arc> <arc class="production" id="prod_06bca0ee-a3a3-4fbb-9e2a-72317eeea72d" source="pr_5e60e04e-939f-455e-8ac6-d46e7ace29e5_p2" target="akt1_s_akt2_s48_akt1_akt2_sa43"> <start x="5244.25" y="3421.0"/> <end x="5259.0" y="3421.0"/> </arc> <arc class="catalysis" id="logicarc_9ea5a5f3-80c1-42e5-8f8e-361fe1f6cada" source="logicglyph_c7786e53-0142-41bc-aa1c-fbdf2937080a_p2" target="pr_5e60e04e-939f-455e-8ac6-d46e7ace29e5"> <start x="5240.2676" y="3431.38"/> <end x="5229.25" y="3426.0"/> </arc> <arc class="logic arc" id="modif_f9fc40e9-2367-4588-a8d3-2cb4898181e5" source="akt1_s_akt2_s49_akt1_akt2_sa44" target="logicglyph_c7786e53-0142-41bc-aa1c-fbdf2937080a_p1"> <start x="5240.0" y="3502.0"/> <end x="5240.2676" y="3471.38"/> </arc> <arc class="logic arc" id="modif_563531a4-1d65-48db-be38-9a14fef7798e" source="akt1_s_akt2_s38_akt1_akt2_sa32" target="logicglyph_c7786e53-0142-41bc-aa1c-fbdf2937080a_p1"> <start x="5525.0" y="3897.0"/> <end x="5240.2676" y="3471.38"/> </arc> <arc class="logic arc" id="modif_a8160555-5623-4926-9c87-6af870a66577" source="akt1_s_akt2_s39_akt1_akt2_sa33" target="logicglyph_c7786e53-0142-41bc-aa1c-fbdf2937080a_p1"> <start x="5696.5" y="3899.0"/> <end x="5240.2676" y="3471.38"/> </arc> <arc class="consumption" id="cons_ee8453d5-63ff-4b0c-b44b-837d575a8ff8" source="akt1_s_akt2_s51_akt1_akt2_sa46" target="pr_6d174000-ec1c-4d77-a67b-8687ecc8cc31_p1"> <start x="5485.0" y="3748.0"/> <end x="5534.625" y="3787.5"/> </arc> <arc class="production" id="prod_6aac5384-2031-4fce-b663-d5cb58a24166" source="pr_6d174000-ec1c-4d77-a67b-8687ecc8cc31_p2" target="akt1_s_akt2_s46_akt1_akt2_sa41"> <start x="5564.625" y="3787.5"/> <end x="5614.25" y="3827.0"/> </arc> <arc class="consumption" id="cons_f9d124c0-7d5d-45f9-9210-c52fc9676268" source="akt1_s_akt2_s48_akt1_akt2_sa43" target="pr_3fb53989-4bcd-47e2-a5f1-139e6270e606_p1"> <start x="5291.5" y="3433.5"/> <end x="5388.25" y="3555.75"/> </arc> <arc class="production" id="prod_648d2b0d-5062-41b0-bfc0-223decc38968" source="pr_3fb53989-4bcd-47e2-a5f1-139e6270e606_p2" target="akt1_s_akt2_s51_akt1_akt2_sa46"> <start x="5388.25" y="3585.75"/> <end x="5485.0" y="3708.0"/> </arc> <arc class="consumption" id="cons_517ee51f-8248-4b84-a328-cfd9097a0170" source="akt1_s_akt2_s218_akt1_akt2_sa34" target="pr_4866aa7c-546b-406e-a99a-1f0d05ffe8fe_p1"> <start x="6754.5" y="3875.0"/> <end x="6260.5" y="3897.0"/> </arc> <arc class="production" id="prod_63e0c028-71fc-4d1c-a3bc-417714bc2305" source="pr_4866aa7c-546b-406e-a99a-1f0d05ffe8fe_p2" target="akt1_s_akt2_s39_akt1_akt2_sa33"> <start x="6230.5" y="3897.0"/> <end x="5736.5" y="3919.0"/> </arc> <arc class="consumption" id="cons_12fdbf0b-ef75-4a12-82d7-43d8c614ae98" source="akt1_s_akt2_s217_akt1_akt2_sa35" target="pr_a3534a04-0e64-4d24-a4a6-984d3cbddc96_p1"> <start x="6754.5" y="3811.0"/> <end x="6174.75" y="3864.0"/> </arc> <arc class="production" id="prod_66e10598-d3c7-4004-bdf4-d5768c57f46d" source="pr_a3534a04-0e64-4d24-a4a6-984d3cbddc96_p2" target="akt1_s_akt2_s38_akt1_akt2_sa32"> <start x="6144.75" y="3864.0"/> <end x="5565.0" y="3917.0"/> </arc> <arc class="consumption" id="cons_1856afee-2c12-4233-8589-5eab903deafe" source="akt1_s_akt2_s438_akt1_akt2_csa9" target="pr_5d17953d-84d2-460d-ab22-4d3cbc27fc69_p1"> <start x="5476.0" y="4277.5"/> <end x="5475.75" y="4288.25"/> </arc> <arc class="production" id="prod_2e4e2009-ee79-465c-bc30-137d74b62b04" source="pr_5d17953d-84d2-460d-ab22-4d3cbc27fc69_p2" target="akt1_s_akt2_s438_akt1_akt2_csa8"> <start x="5475.75" y="4318.25"/> <end x="5475.5" y="4329.0"/> </arc> <arc class="catalysis" id="modif_9274c67f-3755-4b12-ac68-9a4f118ac781" source="akt1_s_akt2_s444_akt1_akt2_csa6" target="pr_5d17953d-84d2-460d-ab22-4d3cbc27fc69"> <start x="5682.0" y="4216.5"/> <end x="5480.75" y="4303.2983"/> </arc> <arc class="consumption" id="cons_e60ec9e1-70db-486b-a2ca-c01f583410bf" source="akt1_s_akt2_s1_akt1_akt2_sa1" target="pr_7d2bbee4-bdba-427e-ad3b-1af874437b72_p1"> <start x="4875.5" y="3139.0"/> <end x="5019.0" y="3047.5"/> </arc> <arc class="production" id="prod_22895c43-ccc3-4ac0-90e1-bb88a1089401" source="pr_7d2bbee4-bdba-427e-ad3b-1af874437b72_p2" target="akt1_s_akt2_s67_akt1_akt2_sa60"> <start x="5049.0" y="3047.5"/> <end x="5192.5" y="2956.0"/> </arc> <arc class="catalysis" id="modif_11be945f-3c5f-40af-b36e-de93634194e4" source="akt1_s_akt2_s442_akt1_akt2_csa10" target="pr_7d2bbee4-bdba-427e-ad3b-1af874437b72"> <start x="5666.0" y="4333.0"/> <end x="5031.5" y="3043.1697"/> </arc> <arc class="consumption" id="cons_46f06eca-0fc6-4649-a4d8-3510852182a8" source="akt1_s_akt2_s438_akt1_akt2_csa8" target="pr_5cd3d29a-ce8c-43c4-a271-32e35b3e97ec_p1"> <start x="5524.0" y="4403.5"/> <next x="5667.0" y="4295.0"/> <end x="5666.4473" y="4301.0"/> </arc> <arc class="consumption" id="cons_3617c795-ea13-4511-b32a-1b5c6b448667" source="akt1_s_akt2_s444_akt1_akt2_csa6" target="pr_5cd3d29a-ce8c-43c4-a271-32e35b3e97ec_p1"> <start x="5682.0" y="4280.0"/> <next x="5667.0" y="4295.0"/> <end x="5666.4473" y="4301.0"/> </arc> <arc class="production" id="prod_7e65161b-aa11-4c9e-8561-9fbd37a832b5" source="pr_5cd3d29a-ce8c-43c4-a271-32e35b3e97ec_p2" target="akt1_s_akt2_s442_akt1_akt2_csa10"> <start x="5666.4473" y="4331.0"/> <end x="5666.0" y="4333.0"/> </arc> <arc class="consumption" id="cons_ef1ac534-426b-4666-acdf-033d82c24851" source="akt1_s_akt2_s7_akt1_akt2_sa7" target="pr_f596602f-567d-40b6-bb3d-5fe3be64a9fe_p1"> <start x="5316.5" y="3025.5"/> <end x="5369.25" y="2875.75"/> </arc> <arc class="production" id="prod_0e56bdd5-4ed5-4d79-95cf-3ca7cb0b247a" source="pr_f596602f-567d-40b6-bb3d-5fe3be64a9fe_p2" target="akt1_s_akt2_s77_akt1_akt2_sa71"> <start x="5369.25" y="2845.75"/> <end x="5422.0" y="2696.0"/> </arc> <arc class="consumption" id="cons_59c61545-151c-41f6-a0f3-ccc60c87a03f" source="akt1_s_akt2_s79_akt1_akt2_sa73" target="pr_956cb6c9-5de9-4a73-a835-f9e78ec8fc9d_p1"> <start x="5600.5" y="3011.0"/> <end x="5600.5" y="3021.25"/> </arc> <arc class="production" id="prod_bfef73ae-41a6-4020-a784-eb65cb4e84be" source="pr_956cb6c9-5de9-4a73-a835-f9e78ec8fc9d_p2" target="akt1_s_akt2_s78_akt1_akt2_sa72"> <start x="5600.5" y="3051.25"/> <end x="5600.5" y="3061.5"/> </arc> <arc class="catalysis" id="modif_eff65e4e-5814-4324-b2c6-ea278f42fb20" source="akt1_s_akt2_s80_akt1_akt2_sa74" target="pr_956cb6c9-5de9-4a73-a835-f9e78ec8fc9d"> <start x="5677.0" y="3036.0"/> <end x="5605.5" y="3036.25"/> </arc> <arc class="catalysis" id="modif_c5b1a698-51a0-4bdb-a3a8-c9d344bb737e" source="akt1_s_akt2_s85_akt1_akt2_sa79" target="pr_956cb6c9-5de9-4a73-a835-f9e78ec8fc9d"> <start x="5477.0" y="3037.0"/> <end x="5595.5" y="3036.25"/> </arc> <arc class="consumption" id="cons_72941194-299d-4f49-a0ae-1c82eacf3fb3" source="akt1_s_akt2_s81_akt1_akt2_sa75" target="pr_54ebf32d-248c-4908-9e99-4444c76825dd_p1"> <start x="5715.0" y="2982.0"/> <end x="5716.0" y="2984.0"/> </arc> <arc class="production" id="prod_40e72748-d237-4fb2-9e04-3a6891fc7bd0" source="pr_54ebf32d-248c-4908-9e99-4444c76825dd_p2" target="akt1_s_akt2_s80_akt1_akt2_sa74"> <start x="5716.0" y="3014.0"/> <end x="5717.0" y="3016.0"/> </arc> <arc class="consumption" id="cons_5ed21c31-568a-4ab0-ad2d-064f57c5ed60" source="akt1_s_akt2_s78_akt1_akt2_sa72" target="pr_e04cd600-1d51-40ec-a890-f5cbcaf97df2_p1"> <start x="5600.5" y="3101.5"/> <end x="5600.5" y="3111.75"/> </arc> <arc class="production" id="prod_79a8e17f-2f36-4454-ad9f-439f274b4612" source="pr_e04cd600-1d51-40ec-a890-f5cbcaf97df2_p2" target="akt1_s_akt2_s84_akt1_akt2_sa77"> <start x="5600.5" y="3141.75"/> <end x="5600.5" y="3152.0"/> </arc> <arc class="catalysis" id="modif_d2032104-b55c-43e2-9f07-3c618c036908" source="akt1_s_akt2_s83_akt1_akt2_sa78" target="pr_e04cd600-1d51-40ec-a890-f5cbcaf97df2"> <start x="5678.0" y="3128.0"/> <end x="5605.5" y="3126.75"/> </arc> <arc class="consumption" id="cons_a13e2563-cf7f-40a1-9389-9d6229537508" source="akt1_s_akt2_s84_akt1_akt2_sa77" target="pr_28ef33e6-abd8-47cc-96a0-56d41f525311_p1"> <start x="5640.5" y="3172.0"/> <end x="5657.75" y="3084.5"/> </arc> <arc class="production" id="prod_a683b38a-ae61-4852-a93e-d65e45246e80" source="pr_28ef33e6-abd8-47cc-96a0-56d41f525311_p2" target="akt1_s_akt2_s81_akt1_akt2_sa75"> <start x="5657.75" y="3054.5"/> <end x="5675.0" y="2967.0"/> </arc> <arc class="consumption" id="cons_de56c5d9-7a2b-467c-a420-a1c4a500b1bb" source="akt1_s_akt2_s86_akt1_akt2_sa80" target="pr_4e3ce083-1b63-4a5f-a4f6-772f492d3e66_p1"> <start x="5437.0" y="2982.0"/> <end x="5437.0" y="2984.5"/> </arc> <arc class="production" id="prod_481f15c1-158c-435c-9eaf-6c4ca9c74d6a" source="pr_4e3ce083-1b63-4a5f-a4f6-772f492d3e66_p2" target="akt1_s_akt2_s85_akt1_akt2_sa79"> <start x="5437.0" y="3014.5"/> <end x="5437.0" y="3017.0"/> </arc> <arc class="consumption" id="cons_b3389368-cc01-459e-ae89-9793eca339a7" source="akt1_s_akt2_s87_akt1_akt2_sa81" target="pr_65cb2e66-0ec9-4d84-8ca2-bf73820748ef_p1"> <start x="5437.0" y="3107.0"/> <next x="5465.362" y="3194.0"/> <end x="5478.358" y="3194.5"/> </arc> <arc class="consumption" id="cons_15083a99-183d-4595-8b24-c3140657ebbd" source="akt1_s_akt2_s88_akt1_akt2_sa82" target="pr_65cb2e66-0ec9-4d84-8ca2-bf73820748ef_p1"> <start x="5437.0" y="3180.0"/> <next x="5465.362" y="3194.0"/> <end x="5478.358" y="3194.5"/> </arc> <arc class="production" id="prod_b03cdf99-622c-41f5-99cf-d0d1562e7f4e" source="pr_65cb2e66-0ec9-4d84-8ca2-bf73820748ef_p2" target="akt1_s_akt2_s96_akt1_akt2_csa11"> <start x="5478.358" y="3224.5"/> <end x="5488.0" y="3221.0"/> </arc> <arc class="consumption" id="addreact_28d51b02-7c32-4d0c-9cb6-d554cd6b9136" source="akt1_s_akt2_s78_akt1_akt2_sa72" target="pr_65cb2e66-0ec9-4d84-8ca2-bf73820748ef_p1"> <start x="5560.5" y="3101.5"/> <end x="5478.358" y="3194.5"/> </arc> <arc class="consumption" id="cons_54e4ab31-4c86-4270-a9c8-ec134f955c1a" source="akt1_s_akt2_s96_akt1_akt2_csa11" target="pr_b23934af-3305-4693-8b7a-5d7f118fd43b_p1"> <start x="5579.0" y="3279.0"/> <end x="5606.0" y="3278.7253"/> </arc> <arc class="production" id="prod_4a527cfc-e43c-41a7-8f3b-98788cea1c22" source="pr_b23934af-3305-4693-8b7a-5d7f118fd43b_p2" target="akt1_s_akt2_s95_akt1_akt2_csa12"> <start x="5636.0" y="3278.7253"/> <next x="5663.0" y="3278.4507"/> <end x="5735.0" y="3279.0"/> </arc> <arc class="production" id="prod_8ec4138e-f24a-437b-872a-2ccf24bc9d1b" source="pr_b23934af-3305-4693-8b7a-5d7f118fd43b_p2" target="akt1_s_akt2_s78_akt1_akt2_sa86"> <start x="5636.0" y="3278.7253"/> <next x="5663.0" y="3278.4507"/> <end x="5738.0" y="3388.0"/> </arc> <arc class="catalysis" id="modif_a6ef74ee-3ac0-4481-a61d-4c00d3c6f4c1" source="akt1_s_akt2_s120_akt1_akt2_csa17" target="pr_b23934af-3305-4693-8b7a-5d7f118fd43b"> <start x="5500.0" y="3364.0"/> <end x="5616.0327" y="3283.7578"/> </arc> <arc class="consumption" id="cons_b0afe62e-2a56-4605-9fd1-a21010582db2" source="akt1_s_akt2_s78_akt1_akt2_sa86" target="pr_a64fbe3e-61ba-4027-ba5a-93101dcfa59d_p1"> <start x="5818.0" y="3388.0"/> <end x="5966.5" y="3275.0"/> </arc> <arc class="production" id="prod_67a19dc8-4bac-4977-9f0d-6ba2abc35679" source="pr_a64fbe3e-61ba-4027-ba5a-93101dcfa59d_p2" target="akt1_s_akt2_s84_akt1_akt2_sa89"> <start x="5996.5" y="3275.0"/> <end x="6145.0" y="3162.0"/> </arc> <arc class="catalysis" id="logicarc_26002cbb-9ff3-4bbc-a588-6863f36d1260" source="logicglyph_1409d098-4075-4455-b903-e424964311d1_p2" target="pr_a64fbe3e-61ba-4027-ba5a-93101dcfa59d"> <start x="5911.4014" y="3244.2107"/> <end x="5982.7705" y="3268.044"/> </arc> <arc class="catalysis" id="modif_79827198-94ad-4e44-8a89-83cd7d27da12" source="akt1_s_akt2_s95_akt1_akt2_csa12" target="pr_a64fbe3e-61ba-4027-ba5a-93101dcfa59d"> <start x="5835.0" y="3309.0"/> <end x="5978.657" y="3270.8867"/> </arc> <arc class="logic arc" id="modif_e6563f04-7cf1-4fc2-8bb3-e104c8c8fbc3" source="akt1_s_akt2_s182_akt1_akt2_sa142" target="logicglyph_1409d098-4075-4455-b903-e424964311d1_p1"> <start x="5938.0" y="3175.0"/> <end x="5871.4014" y="3244.2107"/> </arc> <arc class="logic arc" id="modif_f3da41eb-0688-44e7-8a53-709d77870554" source="akt1_s_akt2_s145_akt1_akt2_sa127" target="logicglyph_1409d098-4075-4455-b903-e424964311d1_p1"> <start x="5722.75" y="3569.0"/> <end x="5871.4014" y="3244.2107"/> </arc> <arc class="logic arc" id="modif_c5887e97-d214-454b-8d12-de9d527fe684" source="akt1_s_akt2_s189_akt1_akt2_sa148" target="logicglyph_1409d098-4075-4455-b903-e424964311d1_p1"> <start x="5819.0" y="3569.0"/> <end x="5871.4014" y="3244.2107"/> </arc> <arc class="consumption" id="cons_f9693192-5280-4463-903f-26886658d79c" source="akt1_s_akt2_s78_akt1_akt2_sa86" target="pr_fd6b3e13-b8f8-4819-b813-30fcdc573fe9_p1"> <start x="5818.0" y="3388.0"/> <next x="6360.0" y="3338.0"/> <end x="6398.5" y="3336.9612"/> </arc> <arc class="consumption" id="cons_f1c80e4e-bded-4d62-9b38-26b152096d89" source="akt1_s_akt2_s101_akt1_akt2_sa92" target="pr_fd6b3e13-b8f8-4819-b813-30fcdc573fe9_p1"> <start x="6361.0" y="3248.0"/> <next x="6360.0" y="3338.0"/> <end x="6398.5" y="3336.9612"/> </arc> <arc class="production" id="prod_8824d847-db02-42dd-9bea-52df539b860c" source="pr_fd6b3e13-b8f8-4819-b813-30fcdc573fe9_p2" target="akt1_s_akt2_s102_akt1_akt2_csa13"> <start x="6428.5" y="3336.9612"/> <end x="6463.0" y="3336.0"/> </arc> <arc class="consumption" id="cons_e863acb6-17ce-4e4a-9d61-9aed7c7f7c9c" source="akt1_s_akt2_s102_akt1_akt2_csa13" target="pr_7979eebb-e4e3-4a04-b152-74415cf2e664_p1"> <start x="6563.0" y="3336.0"/> <end x="6631.25" y="3273.0"/> </arc> <arc class="production" id="prod_1559bae2-ce1d-4af8-a96a-09b7acb0a3e2" source="pr_7979eebb-e4e3-4a04-b152-74415cf2e664_p2" target="akt1_s_akt2_s105_akt1_akt2_csa14"> <start x="6631.25" y="3243.0"/> <end x="6699.5" y="3180.0"/> </arc> <arc class="consumption" id="cons_8a4d2227-7142-450a-8878-d6b2a7d489b5" source="akt1_s_akt2_s105_akt1_akt2_csa14" target="pr_3a95126f-a440-43c6-86e4-d399f4459c1b_p1"> <start x="6749.5" y="3240.0"/> <end x="6749.2734" y="3244.375"/> </arc> <arc class="production" id="prod_69fdbae5-7f54-4d43-a703-c445d44a82bb" source="pr_3a95126f-a440-43c6-86e4-d399f4459c1b_p2" target="akt1_s_akt2_s108_akt1_akt2_sa97"> <start x="6749.2734" y="3274.375"/> <next x="6749.047" y="3278.75"/> <end x="6717.5" y="3307.0"/> </arc> <arc class="production" id="prod_cdb3ece8-b831-40e4-910f-b66419b8d50d" source="pr_3a95126f-a440-43c6-86e4-d399f4459c1b_p2" target="akt1_s_akt2_s109_akt1_akt2_sa98"> <start x="6749.2734" y="3274.375"/> <next x="6749.047" y="3278.75"/> <end x="6805.0" y="3305.0"/> </arc> <arc class="consumption" id="cons_acba27f9-d6ac-427f-bf9f-143e5686133d" source="akt1_s_akt2_s109_akt1_akt2_sa98" target="pr_8d3f762b-e61f-48ec-96d8-ed9b5121d7a9_p1"> <start x="6805.0" y="3345.0"/> <end x="6804.5" y="3351.0"/> </arc> <arc class="production" id="prod_8042e8db-72e1-484a-82a9-e44e808e739a" source="pr_8d3f762b-e61f-48ec-96d8-ed9b5121d7a9_p2" target="akt1_s_akt2_s181_akt1_akt2_sa101"> <start x="6804.5" y="3381.0"/> <end x="6804.0" y="3387.0"/> </arc> <arc class="catalysis" id="logicarc_3cf8112a-b62f-4e5e-9ece-9f9f012ad271" source="logicglyph_2cadcc14-0f84-4968-8da0-abc2b7e68a02_p2" target="pr_8d3f762b-e61f-48ec-96d8-ed9b5121d7a9"> <start x="6754.2456" y="3395.4404"/> <end x="6799.5015" y="3365.881"/> </arc> <arc class="logic arc" id="modif_e3d00443-f50d-48c5-9e17-3421782c65f7" source="akt1_s_akt2_s110_akt1_akt2_csa15" target="logicglyph_2cadcc14-0f84-4968-8da0-abc2b7e68a02_p1"> <start x="6722.0" y="3460.0"/> <end x="6754.2456" y="3435.4404"/> </arc> <arc class="logic arc" id="modif_cdad3a36-7849-4772-bff7-b6e55d161cb1" source="akt1_s_akt2_s145_akt1_akt2_sa127" target="logicglyph_2cadcc14-0f84-4968-8da0-abc2b7e68a02_p1"> <start x="5722.75" y="3569.0"/> <end x="6754.2456" y="3435.4404"/> </arc> <arc class="consumption" id="cons_c63e3d68-c3f8-4987-b262-33c6eb734529" source="akt1_s_akt2_s84_akt1_akt2_sa89" target="pr_d47e4ea6-0163-434a-b6e4-94372a3a0f78_p1"> <start x="6225.0" y="3162.0"/> <end x="6470.0" y="3111.0"/> </arc> <arc class="production" id="prod_afbe3043-0f05-4954-b4f6-e82aa7e46621" source="pr_d47e4ea6-0163-434a-b6e4-94372a3a0f78_p2" target="akt1_s_akt2_s180_akt1_akt2_sa90"> <start x="6500.0" y="3111.0"/> <end x="6745.0" y="3060.0"/> </arc> <arc class="catalysis" id="modif_90fce2af-5a74-44c2-b596-65bf7283e9b7" source="akt1_s_akt2_s114_akt1_akt2_csa16" target="pr_d47e4ea6-0163-434a-b6e4-94372a3a0f78"> <start x="5951.0" y="3122.0"/> <end x="6484.0376" y="3106.0935"/> </arc> <arc class="consumption" id="cons_e9750bea-6d7e-4bad-bf21-2abf2ee6904c" source="akt1_s_akt2_s95_akt1_akt2_csa12" target="pr_1c1c3db3-e93f-4c89-abe5-f9a73f0955c9_p1"> <start x="5785.0" y="3219.0"/> <end x="5802.0" y="3115.5"/> </arc> <arc class="production" id="prod_34eabcdf-aa83-43e4-9969-87b90b1b70f6" source="pr_1c1c3db3-e93f-4c89-abe5-f9a73f0955c9_p2" target="akt1_s_akt2_s119_akt1_akt2_sa106"> <start x="5802.0" y="3085.5"/> <end x="5819.0" y="2982.0"/> </arc> <arc class="consumption" id="cons_71c88d1a-3b2d-4664-89a1-7f231d80ddbd" source="akt1_s_akt2_s77_akt1_akt2_sa71" target="pr_1e8330ca-251d-43da-870b-ab7ebba743ed_p1"> <start x="5422.0" y="2696.0"/> <end x="5511.25" y="2818.5"/> </arc> <arc class="production" id="prod_f47154bd-73d3-4eef-ab9c-d0f787e91454" source="pr_1e8330ca-251d-43da-870b-ab7ebba743ed_p2" target="akt1_s_akt2_s79_akt1_akt2_sa73"> <start x="5511.25" y="2848.5"/> <end x="5600.5" y="2971.0"/> </arc> <arc class="consumption" id="cons_e27edc66-5719-43b1-aa7a-9bc822011fe4" source="akt1_s_akt2_s124_akt1_akt2_csa18" target="pr_b1cd7436-960e-48f0-8ae3-9121c41925c7_p1"> <start x="5723.5" y="2812.5"/> <end x="5586.0" y="3073.25"/> </arc> <arc class="production" id="prod_222fa5c6-8110-4b37-955b-6441f78672c6" source="pr_b1cd7436-960e-48f0-8ae3-9121c41925c7_p2" target="akt1_s_akt2_s120_akt1_akt2_csa17"> <start x="5586.0" y="3103.25"/> <end x="5448.5" y="3364.0"/> </arc> <arc class="consumption" id="cons_f4596c4e-ad69-415c-b618-2784a696cffd" source="akt1_s_akt2_s120_akt1_akt2_csa17" target="pr_25448616-c37d-4764-b0dd-14927a76cc35_p1"> <start x="5448.5" y="3364.0"/> <end x="5422.75" y="3180.5"/> </arc> <arc class="production" id="prod_fba1b3e9-1dad-4e34-9c59-cd2e7b49e637" source="pr_25448616-c37d-4764-b0dd-14927a76cc35_p2" target="akt1_s_akt2_s86_akt1_akt2_sa80"> <start x="5422.75" y="3150.5"/> <end x="5397.0" y="2967.0"/> </arc> <arc class="consumption" id="cons_75a0dcfb-fac0-4868-9340-56619ef3b6d8" source="akt1_s_akt2_s87_akt1_akt2_sa81" target="pr_4cb4b152-9094-40d0-9056-a892acf677ce_p1"> <start x="5477.0" y="3107.0"/> <end x="5516.75" y="3256.0"/> </arc> <arc class="production" id="prod_f8b4f9e7-4739-4c75-b770-81984205c944" source="pr_4cb4b152-9094-40d0-9056-a892acf677ce_p2" target="akt1_s_akt2_s136_akt1_akt2_sa120"> <start x="5516.75" y="3286.0"/> <end x="5556.5" y="3435.0"/> </arc> <arc class="catalysis" id="modif_3aac1338-4eb9-4f94-86db-c756425b8d42" source="akt1_s_akt2_s95_akt1_akt2_csa12" target="pr_4cb4b152-9094-40d0-9056-a892acf677ce"> <start x="5735.0" y="3309.0"/> <end x="5521.6094" y="3269.8223"/> </arc> <arc class="consumption" id="cons_326b7849-8ef5-4705-a8ff-25a7a74d4166" source="akt1_s_akt2_s136_akt1_akt2_sa120" target="pr_f5f0d204-51fc-40ae-a2fa-9617383613f7_p1"> <start x="5596.5" y="3455.0"/> <end x="5614.5" y="3455.0"/> </arc> <arc class="production" id="prod_d2cfa86a-4381-4501-8683-960cdf27f74b" source="pr_f5f0d204-51fc-40ae-a2fa-9617383613f7_p2" target="akt1_s_akt2_s137_akt1_akt2_sa121"> <start x="5644.5" y="3455.0"/> <end x="5662.5" y="3455.0"/> </arc> <arc class="catalysis" id="modif_a825582c-49b5-4c62-9fa8-63a035fc4f00" source="akt1_s_akt2_s135_akt1_akt2_sa119" target="pr_f5f0d204-51fc-40ae-a2fa-9617383613f7"> <start x="5630.0" y="3393.0"/> <end x="5629.5" y="3450.0"/> </arc> <arc class="consumption" id="cons_36a36adb-db5b-454c-b43b-02e12be8c651" source="akt1_s_akt2_s95_akt1_akt2_csa12" target="pr_9e8e4d89-dfd3-468a-b743-e3738ff32e71_p1"> <start x="5835.0" y="3339.0"/> <end x="5889.25" y="3399.75"/> </arc> <arc class="production" id="prod_78398399-8b62-4b40-b978-0fd5fc622af6" source="pr_9e8e4d89-dfd3-468a-b743-e3738ff32e71_p2" target="akt1_s_akt2_s138_akt1_akt2_csa20"> <start x="5919.25" y="3399.75"/> <end x="5973.5" y="3460.5"/> </arc> <arc class="catalysis" id="modif_301e5483-b375-4f46-b361-00f7e6a55362" source="akt1_s_akt2_s95_akt1_akt2_csa12" target="pr_9e8e4d89-dfd3-468a-b743-e3738ff32e71"> <start x="5735.0" y="3279.0"/> <end x="5900.9526" y="3403.5088"/> </arc> <arc class="consumption" id="cons_37bc8dad-b623-49c6-bd38-00404244cff2" source="akt1_s_akt2_s138_akt1_akt2_csa20" target="pr_5ea936ca-e549-454f-b372-23fcf31b75e9_p1"> <start x="6073.5" y="3520.5"/> <end x="6078.25" y="3520.5"/> </arc> <arc class="production" id="prod_7f4db085-f78d-451d-8293-fe865e82cede" source="pr_5ea936ca-e549-454f-b372-23fcf31b75e9_p2" target="akt1_s_akt2_s141_akt1_akt2_csa21"> <start x="6108.25" y="3520.5"/> <end x="6113.0" y="3520.5"/> </arc> <arc class="catalysis" id="modif_c95f5194-26ab-4de9-b04b-6238ee5052d0" source="akt1_s_akt2_s135_akt1_akt2_sa119" target="pr_5ea936ca-e549-454f-b372-23fcf31b75e9"> <start x="5630.0" y="3393.0"/> <end x="6093.25" y="3515.5"/> </arc> <arc class="consumption" id="cons_61995f61-3c1a-4d58-9ef1-e06b90572725" source="akt1_s_akt2_s137_akt1_akt2_sa121" target="pr_211c91a7-f773-4e6f-a95e-c2a27e42cb4f_p1"> <start x="5742.5" y="3455.0"/> <end x="5751.0" y="3455.0"/> </arc> <arc class="production" id="prod_9744e67f-f718-4d41-934b-45eb7a1157bf" source="pr_211c91a7-f773-4e6f-a95e-c2a27e42cb4f_p2" target="akt1_s_akt2_s144_akt1_akt2_sa126"> <start x="5781.0" y="3455.0"/> <end x="5789.5" y="3455.0"/> </arc> <arc class="consumption" id="cons_1f5775fc-6c7e-4610-a151-983f0c291c19" source="akt1_s_akt2_s141_akt1_akt2_csa21" target="pr_5aaed425-7759-4f17-a23e-195fa62219e6_p1"> <start x="6213.0" y="3520.5"/> <end x="6213.75" y="3520.5"/> </arc> <arc class="production" id="prod_fb7dc0db-7d00-4ca4-8290-1e7e7b11cdfd" source="pr_5aaed425-7759-4f17-a23e-195fa62219e6_p2" target="akt1_s_akt2_s150_akt1_akt2_csa22"> <start x="6243.75" y="3520.5"/> <end x="6244.5" y="3520.5"/> </arc> <arc class="consumption" id="cons_cf8a7702-0658-4c3f-b345-a8473046d664" source="akt1_s_akt2_s166_akt1_akt2_sa138" target="pr_27c7fa11-241b-4aa8-96cf-af6cf4d70a1a_p1"> <start x="5199.5" y="3569.0"/> <end x="5214.25" y="3569.0"/> </arc> <arc class="production" id="prod_5d57a486-fcad-4cb0-b6b2-29f861d4e51f" source="pr_27c7fa11-241b-4aa8-96cf-af6cf4d70a1a_p2" target="akt1_s_akt2_s167_akt1_akt2_sa139"> <start x="5244.25" y="3569.0"/> <end x="5259.0" y="3569.0"/> </arc> <arc class="inhibition" id="modif_baa2e625-5fcd-4e79-985c-617e72db110b" source="akt1_s_akt2_s216_akt1_akt2_sa172" target="pr_27c7fa11-241b-4aa8-96cf-af6cf4d70a1a"> <start x="5236.0" y="3616.0"/> <end x="5229.25" y="3574.0"/> </arc> <arc class="catalysis" id="modif_96b5a941-c25f-476c-8486-52a08ef939aa" source="akt1_s_akt2_s195_akt1_akt2_csa25" target="pr_27c7fa11-241b-4aa8-96cf-af6cf4d70a1a"> <start x="5049.0" y="3544.5"/> <end x="5229.25" y="3564.0"/> </arc> <arc class="consumption" id="cons_6d9f1774-a803-4001-ab17-eaf70af61959" source="akt1_s_akt2_s167_akt1_akt2_sa139" target="pr_c1532be4-dfa3-4d33-8a65-f4d1561f8b76_p1"> <start x="5349.0" y="3556.5"/> <end x="5510.5" y="3160.25"/> </arc> <arc class="production" id="prod_3717ae31-bc5b-40f5-a89c-1dcf3acca446" source="pr_c1532be4-dfa3-4d33-8a65-f4d1561f8b76_p2" target="akt1_s_akt2_s124_akt1_akt2_csa18"> <start x="5510.5" y="3130.25"/> <end x="5672.0" y="2734.0"/> </arc> <arc class="consumption" id="cons_2784c9bb-91c1-4de4-8670-571aa2346e0e" source="akt1_s_akt2_s119_akt1_akt2_sa106" target="pr_d057a24f-b40d-425e-8ad8-9649dac904b9_p1"> <start x="5844.0" y="2982.0"/> <end x="5854.5" y="2981.0"/> </arc> <arc class="production" id="prod_ce829237-6c13-4424-bcec-d9c22fd18440" source="pr_d057a24f-b40d-425e-8ad8-9649dac904b9_p2" target="akt1_s_akt2_s114_akt1_akt2_csa16"> <start x="5854.5" y="3011.0"/> <end x="5865.0" y="3010.0"/> </arc> <arc class="consumption" id="cons_2ac7d4d2-5e63-4cd8-baf9-0264bdebc808" source="akt1_s_akt2_s81_akt1_akt2_sa75" target="pr_a0df1046-7946-45bb-84b5-743fba0c7188_p1"> <start x="5740.0" y="2982.0"/> <end x="6193.0" y="3221.0"/> </arc> <arc class="production" id="prod_2081bbc2-00e2-4adb-9f58-16719bf55750" source="pr_a0df1046-7946-45bb-84b5-743fba0c7188_p2" target="akt1_s_akt2_s110_akt1_akt2_csa15"> <start x="6223.0" y="3221.0"/> <end x="6676.0" y="3460.0"/> </arc> <arc class="consumption" id="cons_4212b27d-7659-4b9a-ad50-c4fac3ee446c" source="akt1_s_akt2_s86_akt1_akt2_sa80" target="pr_ab72c698-b138-481f-8bce-4b635613c579_p1"> <start x="5462.0" y="2982.0"/> <end x="5645.0" y="3058.5"/> </arc> <arc class="production" id="prod_8e81f36d-52b3-4f3a-8177-fa4dc7e5ab63" source="pr_ab72c698-b138-481f-8bce-4b635613c579_p2" target="akt1_s_akt2_s182_akt1_akt2_sa142"> <start x="5675.0" y="3058.5"/> <end x="5858.0" y="3135.0"/> </arc> <arc class="consumption" id="cons_b1e91813-1c9b-44f3-949f-607e25005ee7" source="akt1_s_akt2_s184_akt1_akt2_sa143" target="pr_91c155c0-d69d-4786-97e6-5610b8850da2_p1"> <start x="5942.0" y="4377.0"/> <end x="5942.0" y="4392.0"/> </arc> <arc class="production" id="prod_5e744b0e-da2c-4ca8-8496-a0c7d9393baa" source="pr_91c155c0-d69d-4786-97e6-5610b8850da2_p2" target="akt1_s_akt2_s185_akt1_akt2_sa144"> <start x="5942.0" y="4422.0"/> <end x="5942.0" y="4437.0"/> </arc> <arc class="catalysis" id="modif_323bb2e8-a082-429b-b36f-b47e2aac7065" source="akt1_s_akt2_s1_akt1_akt2_sa1" target="pr_91c155c0-d69d-4786-97e6-5610b8850da2"> <start x="4875.5" y="3139.0"/> <end x="5937.0" y="4407.0"/> </arc> <arc class="consumption" id="cons_812b6f6a-78c1-4fbb-8a50-d19563e50a56" source="akt1_s_akt2_s186_akt1_akt2_sa145" target="pr_43c4abe3-400b-49ba-a5a7-935fa9597709_p1"> <start x="5197.5" y="3727.0"/> <end x="5212.25" y="3726.587"/> </arc> <arc class="production" id="prod_81e03de5-cb46-44a9-8a67-916263d683ec" source="pr_43c4abe3-400b-49ba-a5a7-935fa9597709_p2" target="akt1_s_akt2_s187_akt1_akt2_sa146"> <start x="5242.25" y="3726.587"/> <end x="5257.0" y="3726.1736"/> </arc> <arc class="catalysis" id="modif_00451159-98aa-4db6-8335-94a18ea4f811" source="akt1_s_akt2_s188_akt1_akt2_sa147" target="pr_43c4abe3-400b-49ba-a5a7-935fa9597709"> <start x="5967.0" y="4207.0"/> <end x="5227.3193" y="3731.5864"/> </arc> <arc class="consumption" id="cons_3a3a77a2-8e1f-4916-a4a5-35f1d48e5467" source="akt1_s_akt2_s184_akt1_akt2_sa143" target="pr_f219548c-7ad0-4cbe-bd7d-8bcaa664d3bc_p1"> <start x="5902.0" y="4357.0"/> <end x="5902.0" y="4357.0"/> </arc> <arc class="production" id="prod_7996c227-58e0-400b-b9bd-8f409c093e31" source="pr_f219548c-7ad0-4cbe-bd7d-8bcaa664d3bc_p2" target="akt1_s_akt2_s190_akt1_akt2_sa149"> <start x="5872.0" y="4357.0"/> <end x="5872.0" y="4357.0"/> </arc> <arc class="catalysis" id="modif_bfd112fe-f258-4f66-aad7-71279b3245b6" source="akt1_s_akt2_s184_akt1_akt2_sa143" target="pr_f219548c-7ad0-4cbe-bd7d-8bcaa664d3bc"> <start x="5942.0" y="4337.0"/> <next x="5941.996" y="4312.499"/> <next x="5886.993" y="4312.5083"/> <end x="5887.0" y="4352.0"/> </arc> <arc class="inhibition" id="modif_2020575f-b870-450e-94cf-ea8fc31cecb3" source="akt1_s_akt2_s185_akt1_akt2_sa144" target="pr_f219548c-7ad0-4cbe-bd7d-8bcaa664d3bc"> <start x="5902.0" y="4457.0"/> <next x="5886.9985" y="4457.0"/> <next x="5886.9995" y="4400.749"/> <end x="5887.0" y="4362.0"/> </arc> <arc class="catalysis" id="modif_63b44663-d18d-44ed-8cf7-d77ebc8705cf" source="akt1_s_akt2_s145_akt1_akt2_sa127" target="pr_f219548c-7ad0-4cbe-bd7d-8bcaa664d3bc"> <start x="5722.75" y="3609.0"/> <end x="5892.0" y="4352.0"/> </arc> <arc class="catalysis" id="modif_f7d7a6b7-55ad-423a-b36e-a4edb8dbea96" source="akt1_s_akt2_s189_akt1_akt2_sa148" target="pr_f219548c-7ad0-4cbe-bd7d-8bcaa664d3bc"> <start x="5819.0" y="3609.0"/> <end x="5892.0" y="4362.0"/> </arc> <arc class="consumption" id="cons_4bda44c5-98ab-453a-83a9-557eecf8fb0d" source="akt1_s_akt2_s188_akt1_akt2_sa147" target="pr_72db6525-506e-4990-ba2e-ad7710adfe49_p1"> <start x="6007.0" y="4227.0"/> <end x="6030.25" y="4227.0"/> </arc> <arc class="production" id="prod_dc3376fd-25d7-4b45-ac98-d313b9ab8510" source="pr_72db6525-506e-4990-ba2e-ad7710adfe49_p2" target="akt1_s_akt2_s191_akt1_akt2_sa150"> <start x="6060.25" y="4227.0"/> <end x="6083.5" y="4227.0"/> </arc> <arc class="catalysis" id="logicarc_9e580956-0a43-4f6d-b68c-b1487e5b5523" source="logicglyph_95a46d48-c9a8-43a1-9c6d-cb2e2f4cae24_p2" target="pr_72db6525-506e-4990-ba2e-ad7710adfe49"> <start x="5452.75" y="3778.25"/> <end x="6050.25" y="4222.0"/> </arc> <arc class="logic arc" id="modif_341d6b06-d0af-4d21-934c-49a18195fcb7" source="akt1_s_akt2_s185_akt1_akt2_sa144" target="logicglyph_95a46d48-c9a8-43a1-9c6d-cb2e2f4cae24_p1"> <start x="5942.0" y="4437.0"/> <end x="5412.75" y="3778.25"/> </arc> <arc class="logic arc" id="modif_08e2dae7-8b69-41af-87bd-3ff8a486e059" source="akt1_s_akt2_s145_akt1_akt2_sa127" target="logicglyph_95a46d48-c9a8-43a1-9c6d-cb2e2f4cae24_p1"> <start x="5722.75" y="3609.0"/> <end x="5412.75" y="3778.25"/> </arc> <arc class="logic arc" id="modif_598e6492-5c4c-4d69-8d04-93b7af474cd8" source="akt1_s_akt2_s189_akt1_akt2_sa148" target="logicglyph_95a46d48-c9a8-43a1-9c6d-cb2e2f4cae24_p1"> <start x="5819.0" y="3609.0"/> <end x="5412.75" y="3778.25"/> </arc> <arc class="consumption" id="cons_754c0d13-4f4e-4fbf-8bf2-eed40aa1c069" source="akt1_s_akt2_s191_akt1_akt2_sa150" target="pr_0dd6e553-f305-46be-89e6-d057535f4bd4_p1"> <start x="6123.5" y="4247.0"/> <end x="6131.0" y="4523.5"/> </arc> <arc class="production" id="prod_ec0a88f9-c873-49c0-b991-3f06b875c6a9" source="pr_0dd6e553-f305-46be-89e6-d057535f4bd4_p2" target="akt1_s_akt2_s192_akt1_akt2_sa151"> <start x="6131.0" y="4553.5"/> <end x="6138.5" y="4830.0"/> </arc> <arc class="consumption" id="cons_24cf17f5-b8d5-4859-be41-3621f92befed" source="akt1_s_akt2_s28_akt1_akt2_csa5" target="pr_1b481012-b648-434e-922e-f30a503158c9_p1"> <start x="4470.5" y="3133.0"/> <end x="4443.492" y="3117.0"/> </arc> <arc class="production" id="prod_bf2402af-5961-44c4-abf1-8b8e31f5c156" source="pr_1b481012-b648-434e-922e-f30a503158c9_p2" target="akt1_s_akt2_s23_akt1_akt2_sa19"> <start x="4443.492" y="3087.0"/> <next x="4416.485" y="3070.9998"/> <end x="4439.0" y="3061.0"/> </arc> <arc class="production" id="prod_1243ed41-b989-480f-a317-9a4056c8b62d" source="pr_1b481012-b648-434e-922e-f30a503158c9_p2" target="akt1_s_akt2_s193_akt1_akt2_sa152"> <start x="4443.492" y="3087.0"/> <next x="4416.485" y="3070.9998"/> <end x="4472.25" y="2993.0"/> </arc> <arc class="consumption" id="cons_7ae59e70-6cf7-4776-9028-dcb504cfc5ed" source="akt1_s_akt2_s193_akt1_akt2_sa152" target="pr_eca13609-2a0b-44b8-bc94-3750ff336bfe_p1"> <start x="4472.25" y="2953.0"/> <end x="4472.25" y="2912.5"/> </arc> <arc class="production" id="prod_b4cdd7a1-3328-4d97-a499-46d2b6aae705" source="pr_eca13609-2a0b-44b8-bc94-3750ff336bfe_p2" target="akt1_s_akt2_s202_akt1_akt2_sa159"> <start x="4472.25" y="2882.5"/> <end x="4472.25" y="2842.0"/> </arc> <arc class="catalysis" id="logicarc_9532f63b-3c33-4d84-a1e2-96a97c884f23" source="logicglyph_0dd96445-25b7-4e98-a82b-33fa5f87c696_p2" target="pr_eca13609-2a0b-44b8-bc94-3750ff336bfe"> <start x="4565.0" y="2735.75"/> <end x="4477.25" y="2897.5"/> </arc> <arc class="logic arc" id="modif_497ddff0-fe60-41b3-968a-02f4258a9876" source="akt1_s_akt2_s197_akt1_akt2_sa154" target="logicglyph_0dd96445-25b7-4e98-a82b-33fa5f87c696_p1"> <start x="4463.0" y="2676.366"/> <end x="4565.0" y="2695.75"/> </arc> <arc class="logic arc" id="modif_d9544d3c-762d-4210-99c5-f09700d3760e" source="akt1_s_akt2_s200_akt1_akt2_sa157" target="logicglyph_0dd96445-25b7-4e98-a82b-33fa5f87c696_p1"> <start x="4583.8438" y="2676.278"/> <end x="4565.0" y="2695.75"/> </arc> <arc class="logic arc" id="modif_ef86140c-efd5-438b-ac38-34e672b48c34" source="akt1_s_akt2_s201_akt1_akt2_sa158" target="logicglyph_0dd96445-25b7-4e98-a82b-33fa5f87c696_p1"> <start x="4692.5" y="2676.278"/> <end x="4565.0" y="2695.75"/> </arc> <arc class="consumption" id="cons_e96137e7-7436-401c-8419-11862c3b62dc" source="akt1_s_akt2_s188_akt1_akt2_sa147" target="pr_f458ef84-2ea4-442a-8d91-b3a4d770d1e6_p1"> <start x="6007.0" y="4227.0"/> <end x="6030.25" y="4256.0"/> </arc> <arc class="production" id="prod_cf6ccf2c-35f5-4e6d-81f6-ed07e1c76a39" source="pr_f458ef84-2ea4-442a-8d91-b3a4d770d1e6_p2" target="akt1_s_akt2_s203_akt1_akt2_sa160"> <start x="6060.25" y="4256.0"/> <end x="6083.5" y="4285.0"/> </arc> <arc class="catalysis" id="logicarc_0598eede-89fd-4afa-b8f9-9febf47c4016" source="logicglyph_f2da88e6-9af4-470d-85bf-5b652bf93120_p2" target="pr_f458ef84-2ea4-442a-8d91-b3a4d770d1e6"> <start x="5450.0" y="3786.0"/> <end x="6042.229" y="4259.9844"/> </arc> <arc class="logic arc" id="modif_e50f2311-f61f-4b33-9b72-eda8e6ca9fa3" source="akt1_s_akt2_s185_akt1_akt2_sa144" target="logicglyph_f2da88e6-9af4-470d-85bf-5b652bf93120_p1"> <start x="5942.0" y="4437.0"/> <end x="5410.0" y="3786.0"/> </arc> <arc class="logic arc" id="modif_e97388a0-451f-4da5-9fa8-801fe364c6a9" source="akt1_s_akt2_s145_akt1_akt2_sa127" target="logicglyph_f2da88e6-9af4-470d-85bf-5b652bf93120_p1"> <start x="5722.75" y="3609.0"/> <end x="5410.0" y="3786.0"/> </arc> <arc class="logic arc" id="modif_1369b05c-3073-47bb-9ef2-3790177601e2" source="akt1_s_akt2_s189_akt1_akt2_sa148" target="logicglyph_f2da88e6-9af4-470d-85bf-5b652bf93120_p1"> <start x="5819.0" y="3609.0"/> <end x="5410.0" y="3786.0"/> </arc> <arc class="consumption" id="cons_fcded5c9-89e8-459b-9a1b-589846e8350e" source="akt1_s_akt2_s205_akt1_akt2_sa162" target="pr_be90498e-71af-41b1-b37f-bcf7e7475703_p1"> <start x="5199.5" y="3372.0"/> <end x="5214.25" y="3372.0"/> </arc> <arc class="production" id="prod_dcbea2b1-ff5d-437e-9457-0c42377da21e" source="pr_be90498e-71af-41b1-b37f-bcf7e7475703_p2" target="akt1_s_akt2_s206_akt1_akt2_sa163"> <start x="5244.25" y="3372.0"/> <end x="5259.0" y="3372.0"/> </arc> <arc class="catalysis" id="modif_107da78a-0c23-489f-93a1-36af37a98ce9" source="akt1_s_akt2_s435_akt1_akt2_csa1" target="pr_be90498e-71af-41b1-b37f-bcf7e7475703"> <start x="5042.0" y="3079.25"/> <end x="5229.25" y="3367.0"/> </arc> <arc class="catalysis" id="modif_53e31ab0-afab-40a1-8636-70226d3d8660" source="akt1_s_akt2_s195_akt1_akt2_csa25" target="pr_be90498e-71af-41b1-b37f-bcf7e7475703"> <start x="4996.5" y="3494.0"/> <end x="5224.25" y="3377.0"/> </arc> <arc class="consumption" id="cons_0abb8869-6d44-4e84-aa69-71db799ece14" source="akt1_s_akt2_s435_akt1_akt2_csa1" target="pr_8e8a26cb-cccd-4a0a-8b88-db6f775be476_p1"> <start x="5067.0" y="3079.25"/> <end x="5067.0" y="3106.625"/> </arc> <arc class="production" id="prod_1dbc2c49-bd5d-47f9-88d7-d0b50cb5bb6c" source="pr_8e8a26cb-cccd-4a0a-8b88-db6f775be476_p2" target="akt1_s_akt2_s207_akt1_akt2_csa26"> <start x="5067.0" y="3136.625"/> <end x="5067.0" y="3164.0"/> </arc> <arc class="catalysis" id="modif_a62c05e8-36ae-4a61-b98f-b1c320b0b6a1" source="akt1_s_akt2_s213_akt1_akt2_sa169" target="pr_8e8a26cb-cccd-4a0a-8b88-db6f775be476"> <start x="5000.0" y="3170.5"/> <end x="5062.0" y="3121.625"/> </arc> <arc class="consumption" id="cons_b98fb133-2ad7-477e-a646-543eb14c9569" source="akt1_s_akt2_s207_akt1_akt2_csa26" target="pr_2e4fc40c-0c72-4e29-8a10-b9146acecd49_p1"> <start x="5017.0" y="3219.0"/> <end x="5012.625" y="3234.0"/> </arc> <arc class="production" id="prod_2938993c-7933-4aa0-8bf1-3edd461f998e" source="pr_2e4fc40c-0c72-4e29-8a10-b9146acecd49_p2" target="akt1_s_akt2_s210_akt1_akt2_sa166"> <start x="5012.625" y="3204.0"/> <next x="5008.25" y="3219.0"/> <end x="4974.25" y="3260.0"/> </arc> <arc class="production" id="prod_faa8681f-f4bf-4c4c-8ec6-4d328347a4ca" source="pr_2e4fc40c-0c72-4e29-8a10-b9146acecd49_p2" target="akt1_s_akt2_s406_akt1_akt2_sa18"> <start x="5012.625" y="3204.0"/> <next x="5008.25" y="3219.0"/> <end x="4765.25" y="3129.5"/> </arc> <arc class="consumption" id="cons_d00d9a64-dc5f-439e-9496-446296012fa7" source="akt1_s_akt2_s210_akt1_akt2_sa166" target="pr_26c6e6d5-89de-4d30-bd83-ab0f4e80e4a8_p1"> <start x="4934.25" y="3240.0"/> <end x="4980.25" y="3018.837"/> </arc> <arc class="production" id="prod_f0b301d5-10aa-4e15-b0b9-5cc16b90ad4a" source="pr_26c6e6d5-89de-4d30-bd83-ab0f4e80e4a8_p2" target="akt1_s_akt2_s211_akt1_akt2_sa167"> <start x="4980.25" y="2988.837"/> <end x="5026.25" y="2767.6736"/> </arc> <arc class="consumption" id="cons_d320bf9b-3647-486b-9dea-91fb3bac7b66" source="akt1_s_akt2_s214_akt1_akt2_sa170" target="pr_6b5254d1-0922-451b-ab28-e5033bb8b64d_p1"> <start x="5197.5" y="3777.0"/> <end x="5212.25" y="3777.0"/> </arc> <arc class="production" id="prod_3b9cf956-511f-494b-a4a8-8592a77ba744" source="pr_6b5254d1-0922-451b-ab28-e5033bb8b64d_p2" target="akt1_s_akt2_s215_akt1_akt2_sa171"> <start x="5242.25" y="3777.0"/> <end x="5257.0" y="3777.0"/> </arc> <arc class="catalysis" id="modif_f0c81cd9-b246-4922-888b-fd8ce88ea1d8" source="akt1_s_akt2_s435_akt1_akt2_csa1" target="pr_6b5254d1-0922-451b-ab28-e5033bb8b64d"> <start x="5017.0" y="3079.25"/> <end x="5227.25" y="3772.0"/> </arc> <arc class="catalysis" id="modif_a069de3b-ad08-4bc8-a722-a62e3b2d1095" source="akt1_s_akt2_s195_akt1_akt2_csa25" target="pr_6b5254d1-0922-451b-ab28-e5033bb8b64d"> <start x="4996.5" y="3595.0"/> <end x="5232.25" y="3772.0"/> </arc> <arc class="consumption" id="cons_173e2cba-7d46-47d5-96e2-94dfc957eba9" source="akt1_s_akt2_s215_akt1_akt2_sa171" target="pr_b4d81246-45a8-463b-a261-0868614e94c0_p1"> <start x="5324.324" y="3764.5"/> <end x="5280.162" y="3725.25"/> </arc> <arc class="production" id="prod_52112170-a4fd-43f4-9169-f61a5a8532f0" source="pr_b4d81246-45a8-463b-a261-0868614e94c0_p2" target="akt1_s_akt2_s216_akt1_akt2_sa172"> <start x="5280.162" y="3695.25"/> <end x="5236.0" y="3656.0"/> </arc> <arc class="consumption" id="cons_5cbd6ec2-d563-453e-9f3e-8bfe30c61e89" source="akt1_s_akt2_s228_akt1_akt2_csa28" target="pr_a53112d6-94bb-44a7-b6bb-f4e8cad8fbef_p1"> <start x="4982.25" y="3412.5"/> <end x="5001.125" y="3670.0"/> </arc> <arc class="production" id="prod_0ec697c1-ddd2-4c43-a321-a7a06f2b6b15" source="pr_a53112d6-94bb-44a7-b6bb-f4e8cad8fbef_p2" target="akt1_s_akt2_s231_akt1_akt2_csa29"> <start x="5001.125" y="3700.0"/> <end x="5020.0" y="3957.5"/> </arc> <arc class="catalysis" id="modif_cf22fdd0-be41-445e-a2e5-0bde849d76cd" source="akt1_s_akt2_s1_akt1_akt2_sa1" target="pr_a53112d6-94bb-44a7-b6bb-f4e8cad8fbef"> <start x="4875.5" y="3139.0"/> <end x="4996.1367" y="3685.3455"/> </arc> <arc class="consumption" id="cons_1ca469e9-9199-4fd2-ab17-ac9b735a98d5" source="akt1_s_akt2_s303_akt1_akt2_sa182" target="pr_c6e99245-2aee-4704-996a-dcf0be16a006_p1"> <start x="4475.25" y="4917.0"/> <end x="4475.25" y="4933.0"/> </arc> <arc class="production" id="prod_3154e164-8602-413d-8538-402a3e5a4eb3" source="pr_c6e99245-2aee-4704-996a-dcf0be16a006_p2" target="akt1_s_akt2_s304_akt1_akt2_sa183"> <start x="4475.25" y="4963.0"/> <end x="4475.25" y="4979.0"/> </arc> <arc class="catalysis" id="logicarc_bdc4659e-fb13-4efa-8ae7-1149ee07dc08" source="logicglyph_31366f66-983d-42b2-a41d-39301f7a884b_p2" target="pr_c6e99245-2aee-4704-996a-dcf0be16a006"> <start x="4701.0" y="4969.25"/> <end x="4480.25" y="4948.0"/> </arc> <arc class="logic arc" id="modif_e85342cd-5196-437c-93e4-ec46b182a88b" source="akt1_s_akt2_s345_akt1_akt2_csa41" target="logicglyph_31366f66-983d-42b2-a41d-39301f7a884b_p1"> <start x="4765.25" y="4899.0"/> <end x="4741.0" y="4969.25"/> </arc> <arc class="logic arc" id="modif_863a1d85-eed5-4803-9a69-b7d00e7994cf" source="akt1_s_akt2_s201_akt1_akt2_sa245" target="logicglyph_31366f66-983d-42b2-a41d-39301f7a884b_p1"> <start x="4864.625" y="5015.0"/> <end x="4741.0" y="4969.25"/> </arc> <arc class="logic arc" id="modif_deedb014-5c7d-4d06-99d5-2287c9f5b971" source="akt1_s_akt2_s200_akt1_akt2_sa244" target="logicglyph_31366f66-983d-42b2-a41d-39301f7a884b_p1"> <start x="4768.375" y="5015.0"/> <end x="4741.0" y="4969.25"/> </arc> <arc class="consumption" id="cons_090b73ca-1559-4003-95f1-a23dd602c528" source="akt1_s_akt2_s237_akt1_akt2_sa184" target="pr_b59caffe-c894-4530-9a4c-692d243c2c40_p1"> <start x="5198.5" y="3826.0"/> <end x="5213.25" y="3826.0"/> </arc> <arc class="production" id="prod_78383210-6543-40e0-b255-e0d1dd58a962" source="pr_b59caffe-c894-4530-9a4c-692d243c2c40_p2" target="akt1_s_akt2_s238_akt1_akt2_sa185"> <start x="5243.25" y="3826.0"/> <end x="5258.0" y="3826.0"/> </arc> <arc class="catalysis" id="modif_18ce0aa7-7412-4a62-aff7-a7e337d9f5f3" source="akt1_s_akt2_s228_akt1_akt2_csa28" target="pr_b59caffe-c894-4530-9a4c-692d243c2c40"> <start x="5008.5" y="3412.5"/> <end x="5228.25" y="3821.0"/> </arc> <arc class="catalysis" id="modif_dbded7cb-ee8b-485f-9678-e5ef18ce24e5" source="akt1_s_akt2_s435_akt1_akt2_csa1" target="pr_b59caffe-c894-4530-9a4c-692d243c2c40"> <start x="5042.0" y="3079.25"/> <end x="5233.25" y="3821.0"/> </arc> <arc class="consumption" id="cons_fd6ce15b-a11d-4832-9f2c-42fd3b55574f" source="akt1_s_akt2_s241_akt1_akt2_sa188" target="pr_fc4e3fbc-8949-486f-bd89-f81db37ee5df_p1"> <start x="5198.5" y="3944.0"/> <end x="5213.25" y="3944.0"/> </arc> <arc class="production" id="prod_2abc5f46-2a63-4afb-90b3-1a20611bd64f" source="pr_fc4e3fbc-8949-486f-bd89-f81db37ee5df_p2" target="akt1_s_akt2_s242_akt1_akt2_sa189"> <start x="5243.25" y="3944.0"/> <end x="5258.0" y="3944.0"/> </arc> <arc class="catalysis" id="modif_cba0d5bb-45dc-450d-86b2-d12ffc226b2a" source="akt1_s_akt2_s228_akt1_akt2_csa28" target="pr_fc4e3fbc-8949-486f-bd89-f81db37ee5df"> <start x="5008.5" y="3412.5"/> <end x="5223.25" y="3939.0"/> </arc> <arc class="catalysis" id="modif_6b56c915-a7fa-475f-8a8d-81c038ed42b2" source="akt1_s_akt2_s435_akt1_akt2_csa1" target="pr_fc4e3fbc-8949-486f-bd89-f81db37ee5df"> <start x="5067.0" y="3079.25"/> <end x="5233.25" y="3939.0"/> </arc> <arc class="consumption" id="cons_35412cdc-872a-4dd0-ae07-0c164577414d" source="akt1_s_akt2_s243_akt1_akt2_sa190" target="pr_1d5660d5-2543-4708-a736-24b088ba6b30_p1"> <start x="5198.5" y="3993.0"/> <end x="5213.25" y="3993.0"/> </arc> <arc class="production" id="prod_60c25fc6-be07-4a01-b31b-2fd0c88af83e" source="pr_1d5660d5-2543-4708-a736-24b088ba6b30_p2" target="akt1_s_akt2_s244_akt1_akt2_sa191"> <start x="5243.25" y="3993.0"/> <end x="5258.0" y="3993.0"/> </arc> <arc class="catalysis" id="modif_4ea0bb78-4660-4850-a3e1-012c84810330" source="akt1_s_akt2_s228_akt1_akt2_csa28" target="pr_1d5660d5-2543-4708-a736-24b088ba6b30"> <start x="5008.5" y="3412.5"/> <end x="5223.25" y="3988.0"/> </arc> <arc class="catalysis" id="modif_2351557d-1809-420d-9ca5-228568d5b54c" source="akt1_s_akt2_s435_akt1_akt2_csa1" target="pr_1d5660d5-2543-4708-a736-24b088ba6b30"> <start x="5067.0" y="3079.25"/> <end x="5233.25" y="3988.0"/> </arc> <arc class="consumption" id="cons_2d6755b7-2f66-43ac-a625-85494ba85de8" source="akt1_s_akt2_s245_akt1_akt2_sa192" target="pr_f3b78f3a-ffc8-457f-ac47-cab4a56afadd_p1"> <start x="5197.5" y="3685.0"/> <end x="5212.25" y="3685.0"/> </arc> <arc class="production" id="prod_9e7dcb20-72f5-407a-b32d-206b9daebe5a" source="pr_f3b78f3a-ffc8-457f-ac47-cab4a56afadd_p2" target="akt1_s_akt2_s246_akt1_akt2_sa193"> <start x="5242.25" y="3685.0"/> <end x="5257.0" y="3685.0"/> </arc> <arc class="catalysis" id="modif_f6c0b6e9-2d6b-4968-a8f9-6a9527d84db9" source="akt1_s_akt2_s228_akt1_akt2_csa28" target="pr_f3b78f3a-ffc8-457f-ac47-cab4a56afadd"> <start x="5008.5" y="3412.5"/> <end x="5227.25" y="3680.0"/> </arc> <arc class="consumption" id="cons_da875630-b753-41ea-9412-5ce65adb8509" source="akt1_s_akt2_s247_akt1_akt2_sa194" target="pr_55db037f-3036-4b8a-b7c1-439be817743b_p1"> <start x="5198.5" y="4036.0"/> <end x="5213.25" y="4036.0"/> </arc> <arc class="production" id="prod_fc34048d-450f-4167-a199-abbd47d57099" source="pr_55db037f-3036-4b8a-b7c1-439be817743b_p2" target="akt1_s_akt2_s248_akt1_akt2_sa195"> <start x="5243.25" y="4036.0"/> <end x="5258.0" y="4036.0"/> </arc> <arc class="catalysis" id="modif_8ab003e7-327a-4860-8c31-1cfd962312a3" source="akt1_s_akt2_s228_akt1_akt2_csa28" target="pr_55db037f-3036-4b8a-b7c1-439be817743b"> <start x="5008.5" y="3412.5"/> <end x="5228.25" y="4031.0"/> </arc> <arc class="consumption" id="cons_014d559d-91fc-4e9f-95d0-8ea7459ce310" source="akt1_s_akt2_s251_akt1_akt2_sa198" target="pr_8185f9a4-c7b7-4efc-a3bd-5ac9b73e242c_p1"> <start x="5198.5" y="4082.0"/> <end x="5213.25" y="4082.0"/> </arc> <arc class="production" id="prod_d4483a39-a2b5-44bb-a60b-19bfa118b6ed" source="pr_8185f9a4-c7b7-4efc-a3bd-5ac9b73e242c_p2" target="akt1_s_akt2_s252_akt1_akt2_sa199"> <start x="5243.25" y="4082.0"/> <end x="5258.0" y="4082.0"/> </arc> <arc class="catalysis" id="modif_56ce2c13-5709-4d56-9cca-2fe4538f46db" source="akt1_s_akt2_s435_akt1_akt2_csa1" target="pr_8185f9a4-c7b7-4efc-a3bd-5ac9b73e242c"> <start x="5017.0" y="3079.25"/> <end x="5228.25" y="4077.0"/> </arc> <arc class="consumption" id="cons_c3bab7d7-1478-40b6-a61c-f1d0c016b8d1" source="akt1_s_akt2_s253_akt1_akt2_sa200" target="pr_2fba6278-3d28-4d30-8f92-9e8441655c41_p1"> <start x="5198.5" y="3867.0"/> <end x="5213.25" y="3867.0"/> </arc> <arc class="production" id="prod_232e8e8d-4ee5-415e-a793-a52f18223717" source="pr_2fba6278-3d28-4d30-8f92-9e8441655c41_p2" target="akt1_s_akt2_s254_akt1_akt2_sa201"> <start x="5243.25" y="3867.0"/> <end x="5258.0" y="3867.0"/> </arc> <arc class="catalysis" id="modif_e953a871-39a6-4303-8c12-2af202a81095" source="akt1_s_akt2_s228_akt1_akt2_csa28" target="pr_2fba6278-3d28-4d30-8f92-9e8441655c41"> <start x="5008.5" y="3412.5"/> <end x="5223.25" y="3862.0"/> </arc> <arc class="catalysis" id="modif_5ef733b2-6bea-49cb-b671-731042e62127" source="akt1_s_akt2_s435_akt1_akt2_csa1" target="pr_2fba6278-3d28-4d30-8f92-9e8441655c41"> <start x="5117.0" y="3079.25"/> <end x="5233.25" y="3862.0"/> </arc> <arc class="consumption" id="cons_e278d19b-bc9a-44d9-92c6-1d149f70e371" source="akt1_s_akt2_s255_akt1_akt2_sa202" target="pr_eede5ef1-327a-4e3f-8660-8faf023ce0a7_p1"> <start x="5198.5" y="4127.0"/> <end x="5213.25" y="4127.0"/> </arc> <arc class="production" id="prod_f2c94139-7620-49ee-8a0c-d70365df8b97" source="pr_eede5ef1-327a-4e3f-8660-8faf023ce0a7_p2" target="akt1_s_akt2_s256_akt1_akt2_sa203"> <start x="5243.25" y="4127.0"/> <end x="5258.0" y="4127.0"/> </arc> <arc class="catalysis" id="modif_2ec0a4ca-247b-428f-8fc0-7a3e0b5bc11c" source="akt1_s_akt2_s435_akt1_akt2_csa1" target="pr_eede5ef1-327a-4e3f-8660-8faf023ce0a7"> <start x="5117.0" y="3079.25"/> <end x="5228.25" y="4122.0"/> </arc> <arc class="consumption" id="cons_6986e2d3-696b-41e0-852b-612c9e2eefe2" source="akt1_s_akt2_s231_akt1_akt2_csa29" target="pr_1e40b5ba-e8b2-4d76-a39f-04cb89c62471_p1"> <start x="4967.5" y="4008.0"/> <end x="4966.5" y="4008.6665"/> </arc> <arc class="production" id="prod_c2bc17ef-abd4-4f29-a38f-813b21d7c8f9" source="pr_1e40b5ba-e8b2-4d76-a39f-04cb89c62471_p2" target="akt1_s_akt2_s406_akt1_akt2_sa18"> <start x="4936.5" y="4008.6665"/> <next x="4935.5" y="4009.3333"/> <end x="4730.25" y="3129.5"/> </arc> <arc class="production" id="prod_cdbd724c-43d1-4083-8f9c-b12dc1f1c828" source="pr_1e40b5ba-e8b2-4d76-a39f-04cb89c62471_p2" target="akt1_s_akt2_s300_akt1_akt2_sa204"> <start x="4936.5" y="4008.6665"/> <next x="4935.5" y="4009.3333"/> <end x="4911.25" y="4011.0"/> </arc> <arc class="consumption" id="cons_fd850b5e-99ae-4f52-9aae-2159e834e101" source="akt1_s_akt2_s406_akt1_akt2_sa18" target="pr_fe752971-edb0-456a-bfef-a83561e0a7c9_p1"> <start x="4730.25" y="3129.5"/> <next x="4872.5" y="3544.5"/> <end x="4895.25" y="3544.5"/> </arc> <arc class="consumption" id="cons_c3cc0b54-f11b-4aa1-a855-e5f4c311669e" source="akt1_s_akt2_s4_akt1_akt2_sa205" target="pr_fe752971-edb0-456a-bfef-a83561e0a7c9_p1"> <start x="4873.5" y="3570.0"/> <next x="4872.5" y="3544.5"/> <end x="4895.25" y="3544.5"/> </arc> <arc class="production" id="prod_6299ae41-4976-4a1e-b190-b56aab776c51" source="pr_fe752971-edb0-456a-bfef-a83561e0a7c9_p2" target="akt1_s_akt2_s195_akt1_akt2_csa25"> <start x="4925.25" y="3544.5"/> <end x="4944.0" y="3544.5"/> </arc> <arc class="consumption" id="cons_be700cbf-6ae7-4e05-89ab-12554a96afe2" source="akt1_s_akt2_s101_akt1_akt2_sa206" target="pr_5aa17192-c89b-4aeb-9f34-323a4132608d_p1"> <start x="4870.5" y="3797.0"/> <next x="4854.0" y="3781.0"/> <end x="4834.5" y="3801.1692"/> </arc> <arc class="consumption" id="cons_d1fd1178-e30a-428c-b238-34544994cc14" source="akt1_s_akt2_s4_akt1_akt2_sa205" target="pr_5aa17192-c89b-4aeb-9f34-323a4132608d_p1"> <start x="4853.5" y="3610.0"/> <next x="4854.0" y="3781.0"/> <end x="4834.5" y="3801.1692"/> </arc> <arc class="production" id="prod_b6f5cc52-9e08-47cb-8316-803b8ecdc9a0" source="pr_5aa17192-c89b-4aeb-9f34-323a4132608d_p2" target="akt1_s_akt2_s258_akt1_akt2_csa30"> <start x="4804.5" y="3801.1692"/> <end x="4789.0" y="3819.0"/> </arc> <arc class="consumption" id="cons_ddca5bc0-7ce9-47eb-9174-f97f5415e5c3" source="akt1_s_akt2_s258_akt1_akt2_csa30" target="pr_c86d6ea8-8877-49be-bb33-a7918c95629a_p1"> <start x="4689.0" y="3819.0"/> <end x="4611.75" y="3819.5"/> </arc> <arc class="production" id="prod_9e37f6bf-53a9-4b8b-bf2d-4a35490ea436" source="pr_c86d6ea8-8877-49be-bb33-a7918c95629a_p2" target="akt1_s_akt2_s261_akt1_akt2_csa31"> <start x="4581.75" y="3819.5"/> <end x="4504.5" y="3820.0"/> </arc> <arc class="consumption" id="cons_903d5668-4cea-41ad-a3e6-f7b277112378" source="akt1_s_akt2_s261_akt1_akt2_csa31" target="pr_36686a78-af1b-4e48-9ab1-0a27fd3e03db_p1"> <start x="4454.5" y="3760.0"/> <end x="4453.5454" y="3733.0"/> </arc> <arc class="production" id="prod_479d037b-012c-4ab2-a0c4-fae031139202" source="pr_36686a78-af1b-4e48-9ab1-0a27fd3e03db_p2" target="akt1_s_akt2_s108_akt1_akt2_sa211"> <start x="4453.5454" y="3703.0"/> <next x="4452.591" y="3676.0"/> <end x="4542.5" y="3674.0"/> </arc> <arc class="production" id="prod_dd007c9b-d67c-4907-8a62-e6a211acd563" source="pr_36686a78-af1b-4e48-9ab1-0a27fd3e03db_p2" target="akt1_s_akt2_s265_akt1_akt2_sa213"> <start x="4453.5454" y="3703.0"/> <next x="4452.591" y="3676.0"/> <end x="4450.5" y="3587.0"/> </arc> <arc class="consumption" id="cons_be954e91-cfda-478c-93db-e669ef2f2f47" source="akt1_s_akt2_s266_akt1_akt2_csa32" target="pr_ca075c04-b9ba-44fe-85cc-6c233827e677_p1"> <start x="4502.0" y="3345.0"/> <end x="4577.75" y="3409.5"/> </arc> <arc class="production" id="prod_be804842-8ae0-431e-9bd5-c07af49a4f6a" source="pr_ca075c04-b9ba-44fe-85cc-6c233827e677_p2" target="akt1_s_akt2_s270_akt1_akt2_csa33"> <start x="4607.75" y="3409.5"/> <end x="4683.5" y="3474.0"/> </arc> <arc class="consumption" id="cons_1d235a79-9ac8-4e13-a1dc-837f115ca56e" source="akt1_s_akt2_s270_akt1_akt2_csa33" target="pr_78bfce87-17b5-417b-91ed-2412f018cc88_p1"> <start x="4733.5" y="3534.0"/> <end x="4732.8037" y="3545.0"/> </arc> <arc class="production" id="prod_deedf888-34fc-4d94-8bb4-61df6fff3de8" source="pr_78bfce87-17b5-417b-91ed-2412f018cc88_p2" target="akt1_s_akt2_s4_akt1_akt2_sa205"> <start x="4732.8037" y="3575.0"/> <next x="4732.107" y="3586.0"/> <end x="4833.5" y="3590.0"/> </arc> <arc class="production" id="prod_82c655ad-1dbe-4282-ae58-9d9386e634bd" source="pr_78bfce87-17b5-417b-91ed-2412f018cc88_p2" target="akt1_s_akt2_s273_akt1_akt2_sa218"> <start x="4732.8037" y="3575.0"/> <next x="4732.107" y="3586.0"/> <end x="4733.125" y="3652.0"/> </arc> <arc class="consumption" id="cons_5e6520a5-ab68-4be9-9b7d-a1b5a9e1011f" source="akt1_s_akt2_s4_akt1_akt2_sa205" target="pr_6cd72e2f-37e9-44a7-a431-5140f8478036_p1"> <start x="4873.5" y="3610.0"/> <end x="4917.5" y="3725.0"/> </arc> <arc class="production" id="prod_56ee81dd-2821-4da5-94e0-ec48cc633d54" source="pr_6cd72e2f-37e9-44a7-a431-5140f8478036_p2" target="akt1_s_akt2_s276_akt1_akt2_sa219"> <start x="4917.5" y="3755.0"/> <end x="4961.5" y="3870.0"/> </arc> <arc class="catalysis" id="modif_9b9b55c9-c30f-4dac-a025-e69d772a3964" source="akt1_s_akt2_s1_akt1_akt2_sa1" target="pr_6cd72e2f-37e9-44a7-a431-5140f8478036"> <start x="4875.5" y="3139.0"/> <end x="4920.6333" y="3733.661"/> </arc> <arc class="consumption" id="cons_62dfc688-b29d-46a0-881f-0c6977d7b9e9" source="akt1_s_akt2_s265_akt1_akt2_sa213" target="pr_031db9ce-5bef-437e-8174-422412d28be3_p1"> <start x="4450.5" y="3547.0"/> <next x="4451.0" y="3478.0"/> <end x="4451.5273" y="3454.5"/> </arc> <arc class="consumption" id="cons_be980421-f8de-479a-9fd8-973f06c63b42" source="akt1_s_akt2_s268_akt1_akt2_sa214" target="pr_031db9ce-5bef-437e-8174-422412d28be3_p1"> <start x="4465.0" y="3478.0"/> <next x="4451.0" y="3478.0"/> <end x="4451.5273" y="3454.5"/> </arc> <arc class="production" id="prod_79c75d44-d37e-4c9c-9206-6b55d5aa902a" source="pr_031db9ce-5bef-437e-8174-422412d28be3_p2" target="akt1_s_akt2_s266_akt1_akt2_csa32"> <start x="4451.5273" y="3424.5"/> <end x="4452.0" y="3405.0"/> </arc> <arc class="consumption" id="cons_74d993bb-798c-49d6-966c-1e44efa24340" source="akt1_s_akt2_s101_akt1_akt2_sa206" target="pr_5f98e666-df45-42dc-ad54-10d9f1056e44_p1"> <start x="4870.5" y="3837.0"/> <next x="4870.5" y="3890.0"/> <end x="4842.75" y="3924.0952"/> </arc> <arc class="consumption" id="cons_948ed3f0-e67f-45eb-b891-42d7cf3ccbf0" source="akt1_s_akt2_s276_akt1_akt2_sa219" target="pr_5f98e666-df45-42dc-ad54-10d9f1056e44_p1"> <start x="4921.5" y="3890.0"/> <next x="4870.5" y="3890.0"/> <end x="4842.75" y="3924.0952"/> </arc> <arc class="production" id="prod_360df695-a376-4acb-a059-77a695831489" source="pr_5f98e666-df45-42dc-ad54-10d9f1056e44_p2" target="akt1_s_akt2_s277_akt1_akt2_csa34"> <start x="4812.75" y="3924.0952"/> <end x="4789.0" y="3955.0"/> </arc> <arc class="consumption" id="cons_d048a386-d7f7-46b1-bced-a817aaea90b0" source="akt1_s_akt2_s277_akt1_akt2_csa34" target="pr_c75d669b-90be-4275-a4b0-d6fc87ab5599_p1"> <start x="4689.0" y="3955.0"/> <end x="4612.25" y="3956.5"/> </arc> <arc class="production" id="prod_98ef614b-7ee7-43ca-bac7-da4a4b536d08" source="pr_c75d669b-90be-4275-a4b0-d6fc87ab5599_p2" target="akt1_s_akt2_s280_akt1_akt2_csa35"> <start x="4582.25" y="3956.5"/> <end x="4505.5" y="3958.0"/> </arc> <arc class="consumption" id="cons_37b34ea5-ee3e-44d2-8523-5a195b660266" source="akt1_s_akt2_s280_akt1_akt2_csa35" target="pr_c32f9e31-53fb-4fc0-962d-9803eb0f644c_p1"> <start x="4455.5" y="4018.0"/> <end x="4454.5713" y="4029.0"/> </arc> <arc class="production" id="prod_ddeca4dc-f275-425a-bd42-4ca4f2bd562c" source="pr_c32f9e31-53fb-4fc0-962d-9803eb0f644c_p2" target="akt1_s_akt2_s108_akt1_akt2_sa226"> <start x="4454.5713" y="4059.0"/> <next x="4453.643" y="4070.0"/> <end x="4453.5" y="4125.0"/> </arc> <arc class="production" id="prod_34722515-20ca-4290-a205-593c873094b3" source="pr_c32f9e31-53fb-4fc0-962d-9803eb0f644c_p2" target="akt1_s_akt2_s283_akt1_akt2_sa227"> <start x="4454.5713" y="4059.0"/> <next x="4453.643" y="4070.0"/> <end x="4541.5" y="4068.0"/> </arc> <arc class="consumption" id="cons_faca0b86-df61-4592-a776-9ea7bb5fd769" source="akt1_s_akt2_s300_akt1_akt2_sa204" target="pr_642f9321-2d5f-4240-ab9e-5287d4599772_p1"> <start x="4871.25" y="4051.0"/> <next x="4855.5" y="4070.5"/> <end x="4799.75" y="4111.25"/> </arc> <arc class="consumption" id="cons_8d17570f-662b-4e95-be74-1625d2099f05" source="akt1_s_akt2_s24_akt1_akt2_sa20" target="pr_642f9321-2d5f-4240-ab9e-5287d4599772_p1"> <start x="4735.5" y="3210.5"/> <next x="4855.5" y="4070.5"/> <end x="4799.75" y="4111.25"/> </arc> <arc class="production" id="prod_ebddd49a-4901-45f3-aec6-112c21c2afe8" source="pr_642f9321-2d5f-4240-ab9e-5287d4599772_p2" target="akt1_s_akt2_s286_akt1_akt2_csa36"> <start x="4799.75" y="4141.25"/> <end x="4748.0" y="4178.0"/> </arc> <arc class="consumption" id="cons_67a3bceb-7c97-445d-888d-3314c649f8a4" source="akt1_s_akt2_s286_akt1_akt2_csa36" target="pr_dd7ff721-c0ba-4035-819b-70dc62d46150_p1"> <start x="4698.0" y="4238.0"/> <end x="4606.25" y="4319.0"/> </arc> <arc class="production" id="prod_2b962fbf-815e-471d-a522-adab6125b7e2" source="pr_dd7ff721-c0ba-4035-819b-70dc62d46150_p2" target="akt1_s_akt2_s294_akt1_akt2_csa37"> <start x="4606.25" y="4349.0"/> <end x="4514.5" y="4430.0"/> </arc> <arc class="consumption" id="cons_035bbe9c-a27b-4ab6-b7aa-15789f21f466" source="akt1_s_akt2_s294_akt1_akt2_csa37" target="pr_d612a249-be29-42b8-af60-1f656689d34c_p1"> <start x="4464.5" y="4490.0"/> <end x="4466.666" y="4526.5"/> </arc> <arc class="production" id="prod_b0d1ed27-9a23-4b1b-8216-3d3e1e17469d" source="pr_d612a249-be29-42b8-af60-1f656689d34c_p2" target="akt1_s_akt2_s23_akt1_akt2_sa233"> <start x="4466.666" y="4556.5"/> <next x="4468.8315" y="4593.0"/> <end x="4542.5" y="4595.0"/> </arc> <arc class="production" id="prod_2b4440ef-128b-4dc2-a948-3526fa2971d0" source="pr_d612a249-be29-42b8-af60-1f656689d34c_p2" target="akt1_s_akt2_s303_akt1_akt2_sa182"> <start x="4466.666" y="4556.5"/> <next x="4468.8315" y="4593.0"/> <end x="4475.25" y="4877.0"/> </arc> <arc class="consumption" id="cons_180f4c45-bd3a-4920-b39f-c2975a44ab2e" source="akt1_s_akt2_s300_akt1_akt2_sa204" target="pr_1277e090-219c-45fe-ba40-dd0e165a3d83_p1"> <start x="4871.25" y="4051.0"/> <end x="4871.25" y="4081.5"/> </arc> <arc class="production" id="prod_4eaeba18-c413-4adc-8223-a55058063e42" source="pr_1277e090-219c-45fe-ba40-dd0e165a3d83_p2" target="akt1_s_akt2_s307_akt1_akt2_sa228"> <start x="4871.25" y="4111.5"/> <end x="4871.25" y="4142.0"/> </arc> <arc class="catalysis" id="modif_2e882caf-45b0-44bb-a3a6-c97ccdb8cf72" source="akt1_s_akt2_s308_akt1_akt2_sa234" target="pr_1277e090-219c-45fe-ba40-dd0e165a3d83"> <start x="4963.0" y="4097.0"/> <end x="4876.25" y="4096.5"/> </arc> <arc class="consumption" id="cons_8906c6aa-e215-4984-aa89-e7ec7d22ac5f" source="akt1_s_akt2_s307_akt1_akt2_sa228" target="pr_85aeeedf-50a5-4d84-ab76-13c8b7139914_p1"> <start x="4871.25" y="4182.0"/> <end x="4871.25" y="4199.5"/> </arc> <arc class="production" id="prod_737aece5-6c7a-4f87-b072-293c2dae64a2" source="pr_85aeeedf-50a5-4d84-ab76-13c8b7139914_p2" target="akt1_s_akt2_s309_akt1_akt2_sa235"> <start x="4871.25" y="4229.5"/> <end x="4871.25" y="4247.0"/> </arc> <arc class="catalysis" id="modif_1aaa5164-9d81-40db-9e44-b03dd29bca62" source="akt1_s_akt2_s310_akt1_akt2_sa236" target="pr_85aeeedf-50a5-4d84-ab76-13c8b7139914"> <start x="4962.0" y="4214.0"/> <end x="4876.25" y="4214.5"/> </arc> <arc class="consumption" id="cons_2c218f1d-ba42-435c-86f9-2e757769cc35" source="akt1_s_akt2_s309_akt1_akt2_sa235" target="pr_84fe8c53-e347-44bc-b62b-4a5d598ad551_p1"> <start x="4871.25" y="4287.0"/> <next x="4797.25" y="4312.0"/> <end x="4777.554" y="4366.0"/> </arc> <arc class="consumption" id="cons_c4d234ef-c2ce-4eb8-aae6-28a9875f0eec" source="akt1_s_akt2_s101_akt1_akt2_sa206" target="pr_84fe8c53-e347-44bc-b62b-4a5d598ad551_p1"> <start x="4870.5" y="3837.0"/> <next x="4797.25" y="4312.0"/> <end x="4777.554" y="4366.0"/> </arc> <arc class="production" id="prod_3e397993-4b8e-4507-bf2d-6659a559a54e" source="pr_84fe8c53-e347-44bc-b62b-4a5d598ad551_p2" target="akt1_s_akt2_s311_akt1_akt2_csa38"> <start x="4777.554" y="4396.0"/> <end x="4759.0" y="4446.0"/> </arc> <arc class="consumption" id="cons_3f08b8ae-6cd1-4439-bb9e-9f48d1160dad" source="akt1_s_akt2_s311_akt1_akt2_csa38" target="pr_4223d82a-3aa5-477c-ac7c-40720e7eb89a_p1"> <start x="4759.0" y="4566.0"/> <end x="4926.0" y="4697.5"/> </arc> <arc class="production" id="prod_fcb0c0cc-3e18-4876-86cb-075661e2fc69" source="pr_4223d82a-3aa5-477c-ac7c-40720e7eb89a_p2" target="akt1_s_akt2_s325_akt1_akt2_csa39"> <start x="4956.0" y="4697.5"/> <end x="5123.0" y="4829.0"/> </arc> <arc class="consumption" id="cons_09a2df36-5de4-4a73-90e5-99d1b82bd440" source="akt1_s_akt2_s325_akt1_akt2_csa39" target="pr_8336b9de-3329-460c-86a4-ca67586ddea1_p1"> <start x="5073.0" y="4889.0"/> <end x="4876.625" y="4835.259"/> </arc> <arc class="production" id="prod_d86107b7-1ccf-48ce-acd2-17e6d7f6a670" source="pr_8336b9de-3329-460c-86a4-ca67586ddea1_p2" target="akt1_s_akt2_s303_akt1_akt2_sa182"> <start x="4846.625" y="4835.259"/> <next x="4650.25" y="4781.517"/> <end x="4515.25" y="4897.0"/> </arc> <arc class="production" id="prod_4f9775df-abcd-4dde-8840-5f8f691db2fa" source="pr_8336b9de-3329-460c-86a4-ca67586ddea1_p2" target="akt1_s_akt2_s108_akt1_akt2_sa226"> <start x="4846.625" y="4835.259"/> <next x="4650.25" y="4781.517"/> <end x="4453.5" y="4165.0"/> </arc> <arc class="consumption" id="cons_e2c9367b-33cb-4b5f-b690-f20d0a2bf266" source="akt1_s_akt2_s283_akt1_akt2_sa227" target="pr_0e4c37a1-c1ce-4e70-9893-293ddeb31c3c_p1"> <start x="4581.5" y="4088.0"/> <next x="4581.0" y="4257.25"/> <end x="4563.5" y="4259.248"/> </arc> <arc class="consumption" id="cons_f810408b-d95d-40e9-ba4d-3e1a00d5eb12" source="akt1_s_akt2_s23_akt1_akt2_sa233" target="pr_0e4c37a1-c1ce-4e70-9893-293ddeb31c3c_p1"> <start x="4582.5" y="4575.0"/> <next x="4581.0" y="4257.25"/> <end x="4563.5" y="4259.248"/> </arc> <arc class="production" id="prod_577905aa-f57b-4f70-84b2-9b9df2344ee1" source="pr_0e4c37a1-c1ce-4e70-9893-293ddeb31c3c_p2" target="akt1_s_akt2_s328_akt1_akt2_csa40"> <start x="4533.5" y="4259.248"/> <end x="4520.0" y="4261.0"/> </arc> <arc class="consumption" id="cons_19a65dbf-78fc-45a3-bf9d-c668d9922606" source="akt1_s_akt2_s211_akt1_akt2_sa167" target="pr_f60c0a90-773a-4efb-adc3-e8528a06861d_p1"> <start x="5066.25" y="2747.6736"/> <end x="5106.4375" y="2747.6736"/> </arc> <arc class="production" id="prod_a9a60426-7cf0-48ae-8190-5a8db84eb1dc" source="pr_f60c0a90-773a-4efb-adc3-e8528a06861d_p2" target="akt1_s_akt2_s339_akt1_akt2_sa243"> <start x="5136.4375" y="2747.6736"/> <end x="5176.625" y="2747.6736"/> </arc> <arc class="catalysis" id="logicarc_cf339279-e1ff-4204-9b59-ba3d9bbc7069" source="logicglyph_cbb877db-85a6-4288-9bcd-48ac2803d49f_p2" target="pr_f60c0a90-773a-4efb-adc3-e8528a06861d"> <start x="4686.25" y="2683.25"/> <end x="5121.4375" y="2742.6736"/> </arc> <arc class="logic arc" id="modif_56098730-9fce-4868-b95a-05e97db01c5a" source="akt1_s_akt2_s197_akt1_akt2_sa154" target="logicglyph_cbb877db-85a6-4288-9bcd-48ac2803d49f_p1"> <start x="4463.0" y="2676.366"/> <end x="4646.25" y="2683.25"/> </arc> <arc class="logic arc" id="modif_55f4ef6d-742d-4d76-8378-acafd4bcc236" source="akt1_s_akt2_s200_akt1_akt2_sa157" target="logicglyph_cbb877db-85a6-4288-9bcd-48ac2803d49f_p1"> <start x="4583.8438" y="2676.278"/> <end x="4646.25" y="2683.25"/> </arc> <arc class="logic arc" id="modif_c623ef07-dd2e-45f9-b40d-639244b5df58" source="akt1_s_akt2_s201_akt1_akt2_sa158" target="logicglyph_cbb877db-85a6-4288-9bcd-48ac2803d49f_p1"> <start x="4692.5" y="2676.278"/> <end x="4646.25" y="2683.25"/> </arc> <arc class="consumption" id="cons_a1c82863-05dd-4295-840f-0d489053555f" source="akt1_s_akt2_s238_akt1_akt2_sa185" target="pr_7a641519-1b5e-4889-9d27-344a9b1677a6_p1"> <start x="5290.5" y="3838.5"/> <next x="5125.5" y="4306.5"/> <end x="5124.3594" y="4307.75"/> </arc> <arc class="consumption" id="cons_6d0c3171-3a4e-4ee7-bd79-a17e4534822e" source="akt1_s_akt2_s350_akt1_akt2_sa250" target="pr_7a641519-1b5e-4889-9d27-344a9b1677a6_p1"> <start x="5136.0" y="4283.5"/> <next x="5125.5" y="4306.5"/> <end x="5124.3594" y="4307.75"/> </arc> <arc class="production" id="prod_825f7c9f-a096-4463-b20f-a1fb9337450a" source="pr_7a641519-1b5e-4889-9d27-344a9b1677a6_p2" target="akt1_s_akt2_s353_akt1_akt2_csa42"> <start x="5124.3594" y="4337.75"/> <end x="5123.5" y="4335.0"/> </arc> <arc class="consumption" id="cons_4ff038bd-f84d-43be-9015-8c05d287885c" source="akt1_s_akt2_s238_akt1_akt2_sa185" target="pr_e6f035e7-9cd6-4eb1-ad55-f2e3d43ba1f1_p1"> <start x="5290.5" y="3838.5"/> <next x="5233.5" y="4300.5"/> <end x="5233.2207" y="4304.75"/> </arc> <arc class="consumption" id="cons_ab86105c-4257-44db-8e99-3d184b32d443" source="akt1_s_akt2_s351_akt1_akt2_sa251" target="pr_e6f035e7-9cd6-4eb1-ad55-f2e3d43ba1f1_p1"> <start x="5245.5" y="4283.5"/> <next x="5233.5" y="4300.5"/> <end x="5233.2207" y="4304.75"/> </arc> <arc class="production" id="prod_1f7f37b7-0587-45f7-979d-cf5ad480b3d4" source="pr_e6f035e7-9cd6-4eb1-ad55-f2e3d43ba1f1_p2" target="akt1_s_akt2_s354_akt1_akt2_csa43"> <start x="5233.2207" y="4334.75"/> <end x="5233.0" y="4335.0"/> </arc> <arc class="consumption" id="cons_607f1c7c-861d-49df-9e41-8cd797f81913" source="akt1_s_akt2_s238_akt1_akt2_sa185" target="pr_61e3d195-0a13-46e4-9280-702c8d0064d8_p1"> <start x="5290.5" y="3838.5"/> <next x="5346.0" y="4297.5"/> <end x="5344.8936" y="4303.25"/> </arc> <arc class="consumption" id="cons_91708f68-6420-441b-a7ed-fb65f8c81a97" source="akt1_s_akt2_s352_akt1_akt2_sa252" target="pr_61e3d195-0a13-46e4-9280-702c8d0064d8_p1"> <start x="5356.5" y="4283.5"/> <next x="5346.0" y="4297.5"/> <end x="5344.8936" y="4303.25"/> </arc> <arc class="production" id="prod_acf83aad-6496-414d-8446-b377cc3dd561" source="pr_61e3d195-0a13-46e4-9280-702c8d0064d8_p2" target="akt1_s_akt2_s355_akt1_akt2_csa44"> <start x="5344.8936" y="4333.25"/> <end x="5344.0" y="4335.0"/> </arc> <arc class="consumption" id="cons_eb6f7274-4c1c-425e-a3c6-c2b83e00828a" source="akt1_s_akt2_s120_akt1_akt2_csa17" target="pr_8052db6a-b534-4645-8712-2c64ba46bd7a_p1"> <start x="5500.0" y="3442.5"/> <end x="5860.0" y="3225.75"/> </arc> <arc class="production" id="prod_63b4687d-fdbf-4621-b28c-99096ec1148f" source="pr_8052db6a-b534-4645-8712-2c64ba46bd7a_p2" target="akt1_s_akt2_s364_akt1_akt2_csa45"> <start x="5890.0" y="3225.75"/> <end x="6250.0" y="3009.0"/> </arc> <arc class="catalysis" id="modif_448b6312-18f2-4abd-9d9e-d039b61a4341" source="akt1_s_akt2_s135_akt1_akt2_sa119" target="pr_8052db6a-b534-4645-8712-2c64ba46bd7a"> <start x="5630.0" y="3353.0"/> <end x="5877.502" y="3230.0789"/> </arc> <arc class="consumption" id="cons_a73ed59b-d691-4925-a585-3b6c2af03a57" source="akt1_s_akt2_s364_akt1_akt2_csa45" target="pr_eabb9137-f780-43a4-90e4-a41c32354037_p1"> <start x="6301.5" y="3087.5"/> <end x="6236.75" y="3093.475"/> </arc> <arc class="production" id="prod_61770007-3d77-486c-bd2a-1d8253854923" source="pr_eabb9137-f780-43a4-90e4-a41c32354037_p2" target="akt1_s_akt2_s368_akt1_akt2_sa265"> <start x="6206.75" y="3093.475"/> <next x="6142.0" y="3099.4502"/> <end x="6484.0" y="2959.0"/> </arc> <arc class="production" id="prod_f3db7233-7e78-4e2f-b2d6-42a4b8b0a0a2" source="pr_eabb9137-f780-43a4-90e4-a41c32354037_p2" target="akt1_s_akt2_s369_akt1_akt2_sa266"> <start x="6206.75" y="3093.475"/> <next x="6142.0" y="3099.4502"/> <end x="5987.0" y="3293.0"/> </arc> <arc class="production" id="addprod_8181ac8f-37c4-4f28-bf9c-d0b3b768b270" source="pr_eabb9137-f780-43a4-90e4-a41c32354037_p2" target="akt1_s_akt2_s370_akt1_akt2_sa267"> <start x="6206.75" y="3093.475"/> <end x="5970.5" y="2987.0"/> </arc> <arc class="consumption" id="cons_d00d4ae3-9b6a-44ce-9056-024f6c84a1ac" source="akt1_s_akt2_s368_akt1_akt2_sa265" target="pr_aecca330-c69c-4f63-b573-41185d99753c_p1"> <start x="6524.0" y="2979.0"/> <next x="6393.0" y="3124.0"/> <end x="6430.5" y="3141.1533"/> </arc> <arc class="consumption" id="cons_d97c3392-0857-41c3-b6b1-9b5b4c3639a7" source="akt1_s_akt2_s101_akt1_akt2_sa92" target="pr_aecca330-c69c-4f63-b573-41185d99753c_p1"> <start x="6361.0" y="3208.0"/> <next x="6393.0" y="3124.0"/> <end x="6430.5" y="3141.1533"/> </arc> <arc class="production" id="prod_4e135ed5-18f1-474f-b270-69757013062f" source="pr_aecca330-c69c-4f63-b573-41185d99753c_p2" target="akt1_s_akt2_s371_akt1_akt2_csa46"> <start x="6460.5" y="3141.1533"/> <end x="6494.0" y="3157.0"/> </arc> <arc class="consumption" id="cons_08c9c599-b635-434f-8800-562d498af599" source="akt1_s_akt2_s371_akt1_akt2_csa46" target="pr_dc281118-a699-4028-979a-7f821ab4878c_p1"> <start x="6594.0" y="3157.0"/> <end x="6664.25" y="3060.5"/> </arc> <arc class="production" id="prod_339e6a7c-759b-4734-9566-a2b61d33d641" source="pr_dc281118-a699-4028-979a-7f821ab4878c_p2" target="akt1_s_akt2_s374_akt1_akt2_csa47"> <start x="6664.25" y="3030.5"/> <end x="6734.5" y="2934.0"/> </arc> <arc class="consumption" id="cons_d11cd3c9-53bc-4c2a-905a-352b0af91dc9" source="akt1_s_akt2_s369_akt1_akt2_sa266" target="pr_e820509f-ee5d-4f42-b400-4dda064cade0_p1"> <start x="6027.0" y="3313.0"/> <end x="6112.0" y="3312.5"/> </arc> <arc class="production" id="prod_4454a29c-850d-4df6-8572-40d0d25d5565" source="pr_e820509f-ee5d-4f42-b400-4dda064cade0_p2" target="akt1_s_akt2_s377_akt1_akt2_sa272"> <start x="6142.0" y="3312.5"/> <end x="6227.0" y="3312.0"/> </arc> <arc class="catalysis" id="modif_732f2921-e39b-439e-a6a3-4631527db8fa" source="akt1_s_akt2_s182_akt1_akt2_sa273" target="pr_e820509f-ee5d-4f42-b400-4dda064cade0"> <start x="6129.0" y="3380.0"/> <end x="6127.025" y="3317.5"/> </arc> <arc class="consumption" id="cons_8bf2e8ef-c0e9-405d-bea5-b235598f69aa" source="akt1_s_akt2_s381_akt1_akt2_sa275" target="pr_9aaf5d69-a16d-4cdc-81ec-5b38691b1b43_p1"> <start x="6150.0" y="3858.0"/> <end x="6041.5" y="3850.0"/> </arc> <arc class="production" id="prod_d3635d95-cf1d-4ae4-9f27-0e07c84a9662" source="pr_9aaf5d69-a16d-4cdc-81ec-5b38691b1b43_p2" target="akt1_s_akt2_s382_akt1_akt2_sa276"> <start x="6011.5" y="3850.0"/> <end x="5903.0" y="3842.0"/> </arc> <arc class="consumption" id="cons_279292ab-6a68-4d61-8ddb-46597c1cc87d" source="akt1_s_akt2_s381_akt1_akt2_sa275" target="pr_28ba469a-39f3-45d2-b86c-87d17fa051a4_p1"> <start x="6190.0" y="3878.0"/> <next x="6191.0" y="3952.0"/> <end x="6172.2563" y="3958.5"/> </arc> <arc class="consumption" id="cons_2b543095-63df-4edd-8d6d-f3032652dc08" source="akt1_s_akt2_s383_akt1_akt2_sa277" target="pr_28ba469a-39f3-45d2-b86c-87d17fa051a4_p1"> <start x="6305.0" y="3878.0"/> <next x="6191.0" y="3952.0"/> <end x="6172.2563" y="3958.5"/> </arc> <arc class="production" id="prod_396ba2c7-4ceb-4b19-8142-800289e6f493" source="pr_28ba469a-39f3-45d2-b86c-87d17fa051a4_p2" target="akt1_s_akt2_s384_akt1_akt2_csa48"> <start x="6172.2563" y="3988.5"/> <end x="6157.0" y="3991.0"/> </arc> <arc class="consumption" id="cons_dcd95ae8-3d8e-49c0-a311-87691a9f27c1" source="akt1_s_akt2_s383_akt1_akt2_sa277" target="pr_fd22c8f3-ae9b-4f82-bd64-c556f8b0eca1_p1"> <start x="6305.0" y="3838.0"/> <end x="6304.75" y="3819.0"/> </arc> <arc class="production" id="prod_7ae7f8c6-4036-4a09-9c67-086c5110ca70" source="pr_fd22c8f3-ae9b-4f82-bd64-c556f8b0eca1_p2" target="akt1_s_akt2_s387_akt1_akt2_sa280"> <start x="6304.75" y="3789.0"/> <end x="6304.5" y="3770.0"/> </arc> <arc class="catalysis" id="modif_926b9d33-efdc-4169-9953-0494f9eec8e5" source="akt1_s_akt2_s1_akt1_akt2_sa1" target="pr_fd22c8f3-ae9b-4f82-bd64-c556f8b0eca1"> <start x="4875.5" y="3139.0"/> <end x="6299.75" y="3804.0369"/> </arc> <arc class="consumption" id="cons_7a7f2227-5c7b-4439-b2e9-2a51cfa3a266" source="akt1_s_akt2_s388_akt1_akt2_sa281" target="pr_f6be19dd-f2df-45db-8fdc-1812331f21b1_p1"> <start x="6747.5" y="3711.0"/> <end x="6561.25" y="3784.5"/> </arc> <arc class="production" id="prod_aa5ae467-85eb-4379-be0e-f423b64dc7e8" source="pr_f6be19dd-f2df-45db-8fdc-1812331f21b1_p2" target="akt1_s_akt2_s383_akt1_akt2_sa277"> <start x="6531.25" y="3784.5"/> <end x="6345.0" y="3858.0"/> </arc> <arc class="consumption" id="cons_16cf9584-8422-424c-9d04-9a5be4432ae0" source="akt1_s_akt2_s387_akt1_akt2_sa280" target="pr_5c22f74a-c6d4-48fa-a12a-403ff2845b12_p1"> <start x="6304.5" y="3730.0"/> <end x="6305.0" y="3717.0"/> </arc> <arc class="production" id="prod_dc09b530-16ca-4af0-8c43-53125ac7c91d" source="pr_5c22f74a-c6d4-48fa-a12a-403ff2845b12_p2" target="akt1_s_akt2_s389_akt1_akt2_sa282"> <start x="6305.0" y="3687.0"/> <end x="6305.5" y="3674.0"/> </arc> <arc class="catalysis" id="modif_f1c2eda8-9e81-4585-93c4-9f09b11ad211" source="akt1_s_akt2_s1_akt1_akt2_sa1" target="pr_5c22f74a-c6d4-48fa-a12a-403ff2845b12"> <start x="4875.5" y="3139.0"/> <end x="6300.001" y="3701.9106"/> </arc> <arc class="consumption" id="cons_ad0337f3-6459-4d14-849c-f56d859b4552" source="akt1_s_akt2_s389_akt1_akt2_sa282" target="pr_d22e38e3-d79a-4018-9567-bd1240851976_p1"> <start x="6305.5" y="3634.0"/> <next x="6391.0" y="3517.5"/> <end x="6425.5" y="3519.5842"/> </arc> <arc class="consumption" id="cons_68da0f79-c7b5-458f-b977-b9686823ce98" source="akt1_s_akt2_s368_akt1_akt2_sa265" target="pr_d22e38e3-d79a-4018-9567-bd1240851976_p1"> <start x="6524.0" y="2979.0"/> <next x="6391.0" y="3517.5"/> <end x="6425.5" y="3519.5842"/> </arc> <arc class="production" id="prod_d1ae491b-dd69-46cd-bd1b-762116756d89" source="pr_d22e38e3-d79a-4018-9567-bd1240851976_p2" target="akt1_s_akt2_s390_akt1_akt2_csa49"> <start x="6455.5" y="3519.5842"/> <end x="6486.0" y="3521.5"/> </arc> <arc class="consumption" id="addreact_eed8e2cd-22bf-4709-9d1a-deec9831038f" source="akt1_s_akt2_s370_akt1_akt2_sa267" target="pr_d22e38e3-d79a-4018-9567-bd1240851976_p1"> <start x="5970.5" y="2987.0"/> <end x="6425.5" y="3519.5842"/> </arc> <arc class="consumption" id="cons_76bee658-760e-420b-9faf-0968f6b18900" source="akt1_s_akt2_s390_akt1_akt2_csa49" target="pr_5b94627f-3925-488b-ab73-6aacb8b4302c_p1"> <start x="6486.0" y="3441.0"/> <end x="5970.25" y="3211.5"/> </arc> <arc class="production" id="prod_ddc9b241-f597-476c-8f28-6fdc61209d33" source="pr_5b94627f-3925-488b-ab73-6aacb8b4302c_p2" target="akt1_s_akt2_s86_akt1_akt2_sa80"> <start x="5940.25" y="3211.5"/> <end x="5424.5" y="2982.0"/> </arc> <arc class="consumption" id="cons_94bd815b-468f-409f-a911-f4176d227c73" source="akt1_s_akt2_s384_akt1_akt2_csa48" target="pr_d0db1419-b30f-4d94-9374-100521b166a1_p1"> <start x="6107.0" y="4051.0"/> <end x="6102.75" y="4051.0"/> </arc> <arc class="production" id="prod_8faad4c7-5d6e-4372-ad39-c945ed578a8e" source="pr_d0db1419-b30f-4d94-9374-100521b166a1_p2" target="akt1_s_akt2_s399_akt1_akt2_csa51"> <start x="6072.75" y="4051.0"/> <end x="6068.5" y="4051.0"/> </arc> <arc class="catalysis" id="logicarc_bbccd5db-93f0-4fa7-b6f4-72199d7cd233" source="logicglyph_f83782e3-900e-4ed9-91d4-208f5c780533_p2" target="pr_d0db1419-b30f-4d94-9374-100521b166a1"> <start x="5950.5" y="3750.25"/> <end x="6087.75" y="4046.0"/> </arc> <arc class="logic arc" id="modif_9c9d5ef2-0390-4185-a6a9-c0d3991beaff" source="akt1_s_akt2_s145_akt1_akt2_sa127" target="logicglyph_f83782e3-900e-4ed9-91d4-208f5c780533_p1"> <start x="5722.75" y="3609.0"/> <end x="5950.5" y="3710.25"/> </arc> <arc class="logic arc" id="modif_e62391d1-d6a0-4ce1-8f6a-6f7eef71f4b2" source="akt1_s_akt2_s189_akt1_akt2_sa148" target="logicglyph_f83782e3-900e-4ed9-91d4-208f5c780533_p1"> <start x="5819.0" y="3609.0"/> <end x="5950.5" y="3710.25"/> </arc> <arc class="logic arc" id="modif_da7743b5-b914-426a-a72e-3dc387504ad1" source="akt1_s_akt2_s394_akt1_akt2_csa50" target="logicglyph_f83782e3-900e-4ed9-91d4-208f5c780533_p1"> <start x="6401.0" y="3711.0"/> <end x="5950.5" y="3710.25"/> </arc> <arc class="consumption" id="cons_6b40c089-750f-48e9-aaff-74ba12b7aa3e" source="akt1_s_akt2_s402_akt1_akt2_sa292" target="pr_586de639-3bc3-4bed-9f8e-76d779d8def2_p1"> <start x="6449.0" y="4527.0"/> <end x="6466.0" y="4527.0"/> </arc> <arc class="production" id="prod_174d0d4e-825e-4b3c-aeaf-5a40ad499999" source="pr_586de639-3bc3-4bed-9f8e-76d779d8def2_p2" target="akt1_s_akt2_s403_akt1_akt2_sa293"> <start x="6496.0" y="4527.0"/> <end x="6513.0" y="4527.0"/> </arc> <arc class="catalysis" id="modif_71d7fe3f-471c-456d-950c-f8d4e54e6039" source="akt1_s_akt2_s408_akt1_akt2_csa52" target="pr_586de639-3bc3-4bed-9f8e-76d779d8def2"> <start x="6352.0" y="4494.5"/> <end x="6481.0" y="4522.0"/> </arc> <arc class="consumption" id="cons_4c9e08e9-f496-446a-96c1-f25e997dc60b" source="akt1_s_akt2_s404_akt1_akt2_sa294" target="pr_fb6234b2-ca48-4ff2-96c4-bba08f4b6fc4_p1"> <start x="6086.0" y="4504.0"/> <end x="6097.125" y="4505.0"/> </arc> <arc class="production" id="prod_663adca4-a725-493d-be35-27cb1fce4c26" source="pr_fb6234b2-ca48-4ff2-96c4-bba08f4b6fc4_p2" target="akt1_s_akt2_s407_akt1_akt2_sa297"> <start x="6127.125" y="4505.0"/> <end x="6138.25" y="4506.0"/> </arc> <arc class="catalysis" id="modif_d259889b-48a6-4f06-a29e-6c0b6c22d179" source="akt1_s_akt2_s1_akt1_akt2_sa1" target="pr_fb6234b2-ca48-4ff2-96c4-bba08f4b6fc4"> <start x="4875.5" y="3139.0"/> <end x="6112.3164" y="4500.0034"/> </arc> <arc class="consumption" id="cons_73f5e06a-511d-428b-9f96-3198765a2e2c" source="akt1_s_akt2_s407_akt1_akt2_sa297" target="pr_5fdc7856-43d3-402b-a5ee-1db4ee74b22a_p1"> <start x="6218.25" y="4506.0"/> <next x="6236.0" y="4494.5"/> <end x="6244.5" y="4509.5"/> </arc> <arc class="consumption" id="cons_263565cf-c2b3-4e90-858d-306545bce779" source="akt1_s_akt2_s406_akt1_akt2_sa296" target="pr_5fdc7856-43d3-402b-a5ee-1db4ee74b22a_p1"> <start x="6210.0" y="4565.0"/> <next x="6236.0" y="4494.5"/> <end x="6244.5" y="4509.5"/> </arc> <arc class="production" id="prod_609a5ecd-9041-4e2f-9707-5f2b0420e5ec" source="pr_5fdc7856-43d3-402b-a5ee-1db4ee74b22a_p2" target="akt1_s_akt2_s408_akt1_akt2_csa52"> <start x="6244.5" y="4479.5"/> <end x="6249.0" y="4494.5"/> </arc> <arc class="consumption" id="addreact_72bb5090-9977-4b4a-a455-9928b60f3f52" source="akt1_s_akt2_s409_akt1_akt2_sa298" target="pr_5fdc7856-43d3-402b-a5ee-1db4ee74b22a_p1"> <start x="6215.0" y="4444.0"/> <end x="6244.5" y="4509.5"/> </arc> <arc class="consumption" id="cons_dad9068c-ec63-4c72-bd24-befc46f8527e" source="akt1_s_akt2_s412_akt1_akt2_sa302" target="pr_402dbc17-afe2-4d47-8399-635d4c8446bd_p1"> <start x="6449.0" y="4478.0"/> <end x="6466.0" y="4478.0"/> </arc> <arc class="production" id="prod_72f3824b-63a7-4c8d-b307-ee41ef0ebbc2" source="pr_402dbc17-afe2-4d47-8399-635d4c8446bd_p2" target="akt1_s_akt2_s413_akt1_akt2_sa303"> <start x="6496.0" y="4478.0"/> <end x="6513.0" y="4478.0"/> </arc> <arc class="catalysis" id="modif_07a79990-503a-435c-b18c-0304a2073123" source="akt1_s_akt2_s408_akt1_akt2_csa52" target="pr_402dbc17-afe2-4d47-8399-635d4c8446bd"> <start x="6352.0" y="4494.5"/> <end x="6481.0" y="4483.0"/> </arc> <arc class="consumption" id="cons_31279c9d-7435-4253-b73d-0350093b1336" source="akt1_s_akt2_s414_akt1_akt2_sa304" target="pr_3e4c7823-57f4-407d-b489-f7bec3f605ec_p1"> <start x="4898.0" y="4445.0"/> <next x="4900.0" y="4395.0"/> <end x="4911.5" y="4395.0"/> </arc> <arc class="consumption" id="cons_a2e7893b-b35c-40fd-99bb-29d6e1b9368e" source="akt1_s_akt2_s415_akt1_akt2_sa305" target="pr_3e4c7823-57f4-407d-b489-f7bec3f605ec_p1"> <start x="4898.0" y="4350.0"/> <next x="4900.0" y="4395.0"/> <end x="4911.5" y="4395.0"/> </arc> <arc class="production" id="prod_650b9860-3a01-4cd6-ad6e-11db61a60005" source="pr_3e4c7823-57f4-407d-b489-f7bec3f605ec_p2" target="akt1_s_akt2_s416_akt1_akt2_csa53"> <start x="4941.5" y="4395.0"/> <end x="4949.0" y="4395.0"/> </arc> <arc class="consumption" id="cons_21025441-78c0-4285-83a1-ded92f319e40" source="akt1_s_akt2_s428_akt1_akt2_sa309" target="pr_71eb81d0-2120-4ced-956a-43efd4f58234_p1"> <start x="6421.0" y="4176.0"/> <next x="6482.0" y="4130.5"/> <end x="6480.949" y="4104.25"/> </arc> <arc class="consumption" id="cons_e2565a15-c90d-474c-b45b-8b316dc6bd09" source="akt1_s_akt2_s406_akt1_akt2_sa310" target="pr_71eb81d0-2120-4ced-956a-43efd4f58234_p1"> <start x="6548.5" y="4183.0"/> <next x="6482.0" y="4130.5"/> <end x="6480.949" y="4104.25"/> </arc> <arc class="production" id="prod_38a19973-2b1a-4339-89da-8e75b02cb741" source="pr_71eb81d0-2120-4ced-956a-43efd4f58234_p2" target="akt1_s_akt2_s446_akt1_akt2_csa54"> <start x="6480.949" y="4074.25"/> <end x="6480.0" y="4052.0"/> </arc> <arc class="consumption" id="cons_8588096b-ef8a-422a-82ca-57741ca99c0c" source="akt1_s_akt2_s427_akt1_akt2_sa308" target="pr_ee8711f4-903c-47d0-97ca-657433f37ae3_p1"> <start x="6280.25" y="4176.0"/> <next x="6334.0" y="4126.8125"/> <end x="6339.2676" y="4102.4062"/> </arc> <arc class="consumption" id="cons_e51bd4a1-7035-41ce-b80e-7d0758861895" source="akt1_s_akt2_s428_akt1_akt2_sa309" target="pr_ee8711f4-903c-47d0-97ca-657433f37ae3_p1"> <start x="6421.0" y="4176.0"/> <next x="6334.0" y="4126.8125"/> <end x="6339.2676" y="4102.4062"/> </arc> <arc class="production" id="prod_278f18ba-8d7a-46fa-b600-edb7e9b2901d" source="pr_ee8711f4-903c-47d0-97ca-657433f37ae3_p2" target="akt1_s_akt2_s432_akt1_akt2_csa55"> <start x="6339.2676" y="4072.4062"/> <end x="6344.0" y="4052.0"/> </arc> <arc class="consumption" id="cons_e4e411a2-98e8-4dc9-9204-a0b2b4eb29dc" source="akt1_s_akt2_s427_akt1_akt2_sa308" target="pr_ded0aaa4-bafe-4e79-8191-25fa132e0be3_p1"> <start x="6240.25" y="4196.0"/> <end x="5590.75" y="4113.5"/> </arc> <arc class="production" id="prod_04c4f2a7-2df9-4a74-8be7-e3370915460a" source="pr_ded0aaa4-bafe-4e79-8191-25fa132e0be3_p2" target="akt1_s_akt2_s300_akt1_akt2_sa204"> <start x="5560.75" y="4113.5"/> <end x="4911.25" y="4031.0"/> </arc> <arc class="catalysis" id="modif_4f2366f6-4f76-441e-a329-155c583b730a" source="akt1_s_akt2_s1_akt1_akt2_sa1" target="pr_ded0aaa4-bafe-4e79-8191-25fa132e0be3"> <start x="4875.5" y="3139.0"/> <end x="5576.366" y="4108.538"/> </arc> <arc class="consumption" id="cons_1407710d-1a4f-41a8-a703-af923f87c2f5" source="wnc1_s_wnc1_s1_wnc1_wnc1_sa1" target="pr_581426cc-480d-47fe-960b-c1916a757908_p1"> <start x="7958.0" y="533.0"/> <end x="7982.25" y="533.0"/> </arc> <arc class="production" id="prod_bad62957-f972-43fd-8b1e-994a63b0a716" source="pr_581426cc-480d-47fe-960b-c1916a757908_p2" target="wnc1_s_wnc1_s2_wnc1_wnc1_sa2"> <start x="8012.25" y="533.0"/> <end x="8036.5" y="533.0"/> </arc> <arc class="catalysis" id="modif_00182697-5c24-4ea1-843e-52d9d0281fb8" source="wnc1_s_wnc1_s1163_wnc1_wnc1_csa1" target="pr_581426cc-480d-47fe-960b-c1916a757908"> <start x="7997.0" y="583.0"/> <end x="7997.25" y="538.0"/> </arc> <arc class="catalysis" id="modif_c7e745e9-6341-4bf4-aa12-73fc59db9c57" source="wnc1_s_wnc1_s1143_wnc1_wnc1_csa3" target="pr_581426cc-480d-47fe-960b-c1916a757908"> <start x="7487.0" y="350.0"/> <end x="7992.25" y="528.0"/> </arc> <arc class="consumption" id="cons_95af7c44-2ed0-4219-9a5c-dd40b5a4f031" source="wnc1_s_wnc1_s6_wnc1_wnc1_sa5" target="pr_25882ea0-cfac-4cf9-87a5-38f5f84db37a_p1"> <start x="8172.0" y="469.0"/> <end x="8172.0" y="518.0"/> </arc> <arc class="production" id="prod_dd4f49ca-2083-4ab7-8958-fd444938c1a3" source="pr_25882ea0-cfac-4cf9-87a5-38f5f84db37a_p2" target="wnc1_s_wnc1_s7_wnc1_wnc1_sa6"> <start x="8172.0" y="548.0"/> <end x="8172.0" y="597.0"/> </arc> <arc class="catalysis" id="modif_b9b3498a-5af1-47c5-8221-afeb1fee9bd8" source="wnc1_s_wnc1_s2_wnc1_wnc1_sa2" target="pr_25882ea0-cfac-4cf9-87a5-38f5f84db37a"> <start x="8116.5" y="533.0"/> <end x="8167.0" y="533.0"/> </arc> <arc class="catalysis" id="modif_0a6dedc6-e614-4a5f-9c49-821e95badd40" source="wnc1_s_wnc1_s10_wnc1_wnc1_sa9" target="pr_25882ea0-cfac-4cf9-87a5-38f5f84db37a"> <start x="8277.0" y="615.0"/> <end x="8177.0" y="533.0"/> </arc> <arc class="consumption" id="cons_779a431a-8a9c-46bf-a4f9-b9a7ada93360" source="wnc1_s_wnc1_s71_wnc1_wnc1_sa11" target="pr_33ede13b-c54a-45e6-9601-b2b3229b2ab3_p1"> <start x="8172.0" y="750.0"/> <end x="8172.0" y="816.54895"/> </arc> <arc class="production" id="prod_4b71039d-9e31-43a7-9fa0-d9d30ee8117e" source="pr_33ede13b-c54a-45e6-9601-b2b3229b2ab3_p2" target="wnc1_s_wnc1_s72_wnc1_wnc1_sa7"> <start x="8172.0" y="846.54895"/> <end x="8172.0" y="913.0979"/> </arc> <arc class="consumption" id="cons_f55e8bbf-0d1b-42e3-b344-4cd5e9257af4" source="wnc1_s_wnc1_s1142_wnc1_wnc1_csa2" target="pr_0df6b883-d534-49e1-8ea5-a6dcd8d0e32a_p1"> <start x="7355.0" y="299.0"/> <end x="7369.5" y="298.5"/> </arc> <arc class="production" id="prod_55811e26-d1eb-4b1e-b618-6a153b3f7909" source="pr_0df6b883-d534-49e1-8ea5-a6dcd8d0e32a_p2" target="wnc1_s_wnc1_s1143_wnc1_wnc1_csa3"> <start x="7399.5" y="298.5"/> <end x="7414.0" y="298.0"/> </arc> <arc class="catalysis" id="modif_4bcf9a97-5826-4ee2-b71f-e60745625821" source="wnc1_s_wnc1_s15_wnc1_wnc1_sa15" target="pr_0df6b883-d534-49e1-8ea5-a6dcd8d0e32a"> <start x="7336.0" y="204.0"/> <end x="7379.416" y="293.58545"/> </arc> <arc class="catalysis" id="modif_8f4a4067-01ab-4c70-aa05-c7b98c0bdc9d" source="wnc1_s_wnc1_s16_wnc1_wnc1_sa16" target="pr_0df6b883-d534-49e1-8ea5-a6dcd8d0e32a"> <start x="7424.0" y="204.0"/> <end x="7389.4146" y="293.416"/> </arc> <arc class="consumption" id="cons_603f6a29-7930-4d1a-8c23-f7e47fded9fc" source="wnc1_s_wnc1_s1143_wnc1_wnc1_csa3" target="pr_9e2c43e1-972f-483d-b4ae-5b4181ef5b6b_p1"> <start x="7560.0" y="298.0"/> <end x="7584.75" y="298.5"/> </arc> <arc class="production" id="prod_6f3198f5-f713-436d-b80e-f432c1767896" source="pr_9e2c43e1-972f-483d-b4ae-5b4181ef5b6b_p2" target="wnc1_s_wnc1_s1144_wnc1_wnc1_csa4"> <start x="7614.75" y="298.5"/> <end x="7639.5" y="299.0"/> </arc> <arc class="consumption" id="addreact_a2ff5911-ca62-4388-bdfb-23b695a69687" source="wnc1_s_wnc1_s30_wnc1_wnc1_sa29" target="pr_9e2c43e1-972f-483d-b4ae-5b4181ef5b6b_p1"> <start x="7571.2324" y="392.5"/> <end x="7584.75" y="298.5"/> </arc> <arc class="consumption" id="addreact_83c25ef3-173c-464d-b4dd-395900939aca" source="wnc1_s_wnc1_s54_wnc1_wnc1_sa47" target="pr_9e2c43e1-972f-483d-b4ae-5b4181ef5b6b_p1"> <start x="7522.0" y="410.0"/> <end x="7584.75" y="298.5"/> </arc> <arc class="production" id="addprod_dbea7e67-8163-4bcb-b9f4-a19b5194af0f" source="pr_9e2c43e1-972f-483d-b4ae-5b4181ef5b6b_p2" target="wnc1_s_wnc1_s29_wnc1_wnc1_sa36"> <start x="7614.75" y="298.5"/> <end x="7626.939" y="392.5"/> </arc> <arc class="consumption" id="cons_50cd094a-1f10-4706-a64c-b76543ed0219" source="wnc1_s_wnc1_s1144_wnc1_wnc1_csa4" target="pr_aea07624-514c-40f0-b697-cde3d4a8cc2a_p1"> <start x="7791.5" y="299.0"/> <end x="7787.625" y="298.57617"/> </arc> <arc class="production" id="prod_7eb3c3e5-02ec-4e2f-9dcc-ab3df62c2a4c" source="pr_aea07624-514c-40f0-b697-cde3d4a8cc2a_p2" target="wnc1_s_wnc1_s45_wnc1_wnc1_sa38"> <start x="7817.625" y="298.57617"/> <next x="7813.75" y="298.15237"/> <end x="7854.5" y="283.0"/> </arc> <arc class="production" id="prod_49cf2d77-a0b7-4066-a438-bbc2247489b7" source="pr_aea07624-514c-40f0-b697-cde3d4a8cc2a_p2" target="wnc1_s_wnc1_s46_wnc1_wnc1_csa5"> <start x="7817.625" y="298.57617"/> <next x="7813.75" y="298.15237"/> <end x="7858.0" y="361.0"/> </arc> <arc class="production" id="addprod_f847e4cb-f5d2-4e0a-b40b-6ca3feef9ed6" source="pr_aea07624-514c-40f0-b697-cde3d4a8cc2a_p2" target="wnc1_s_wnc1_s58_wnc1_wnc1_csa8"> <start x="7817.625" y="298.57617"/> <end x="7806.5" y="407.0"/> </arc> <arc class="consumption" id="cons_de24c361-7981-4051-bfc0-7dead74cf69d" source="wnc1_s_wnc1_s58_wnc1_wnc1_csa8" target="pr_a26866ec-1c9c-4350-a159-47fec14f8dbb_p1"> <start x="7806.5" y="504.0"/> <next x="7744.375" y="542.63403"/> <end x="7649.1875" y="554.02374"/> </arc> <arc class="consumption" id="cons_4f4b3857-fe47-475e-8b12-47b9aa50930b" source="wnc1_s_wnc1_s67_wnc1_wnc1_sa41" target="pr_a26866ec-1c9c-4350-a159-47fec14f8dbb_p1"> <start x="7812.75" y="585.0"/> <next x="7744.375" y="542.63403"/> <end x="7649.1875" y="554.02374"/> </arc> <arc class="production" id="prod_1f60e07e-803e-4002-9581-d2320b29bfab" source="pr_a26866ec-1c9c-4350-a159-47fec14f8dbb_p2" target="wnc1_s_wnc1_s61_wnc1_wnc1_csa6"> <start x="7619.1875" y="554.02374"/> <end x="7528.0" y="565.0"/> </arc> <arc class="consumption" id="cons_a8f8e3c7-ed71-43bd-b29d-f6e17962bb63" source="wnc1_s_wnc1_s61_wnc1_wnc1_csa6" target="pr_ff79e8ea-ca90-4b74-a002-59423a8fb396_p1"> <start x="7424.0" y="565.0"/> <end x="7353.75" y="565.0"/> </arc> <arc class="production" id="prod_31ee7823-4b2f-4067-8ec8-31379884f13a" source="pr_ff79e8ea-ca90-4b74-a002-59423a8fb396_p2" target="wnc1_s_wnc1_s62_wnc1_wnc1_csa9"> <start x="7323.75" y="565.0"/> <end x="7253.5" y="565.0"/> </arc> <arc class="consumption" id="cons_c0c28f95-35b5-45d3-bfee-3bfb261ce308" source="wnc1_s_wnc1_s13_wnc1_wnc1_sa55" target="pr_fd50b087-3c9d-42d2-addc-56c234e4bdeb_p1"> <start x="7812.75" y="665.0"/> <end x="7812.75" y="660.0"/> </arc> <arc class="production" id="prod_9147471b-7d7b-4eb1-870b-63553e930022" source="pr_fd50b087-3c9d-42d2-addc-56c234e4bdeb_p2" target="wnc1_s_wnc1_s67_wnc1_wnc1_sa41"> <start x="7812.75" y="630.0"/> <end x="7812.75" y="625.0"/> </arc> <arc class="catalysis" id="modif_5fdc0004-be90-41e8-abd2-00b1725933b8" source="wnc1_s_wnc1_s1143_wnc1_wnc1_csa3" target="pr_fd50b087-3c9d-42d2-addc-56c234e4bdeb"> <start x="7487.0" y="350.0"/> <end x="7807.75" y="645.0"/> </arc> <arc class="stimulation" id="direct_23bab86b-84c3-4654-8280-fabc670f3ec9" source="wnc1_s_wnc1_s62_wnc1_wnc1_csa9" target="wnc1_s_wnc1_s70_wnc1_wnc1_sa56"> <start x="7201.5" y="636.0"/> <end x="8260.5" y="880.75525"/> </arc> <arc class="consumption" id="cons_ff669039-1620-4b6a-8330-d319e3dded40" source="wnc1_s_wnc1_s7_wnc1_wnc1_sa6" target="pr_915ba5d5-dc4a-4361-8484-738621b9e170_p1"> <start x="8172.0" y="637.0"/> <end x="8172.0" y="658.5"/> </arc> <arc class="production" id="prod_3c7c2109-259f-4118-ba32-a7eb7bff6ece" source="pr_915ba5d5-dc4a-4361-8484-738621b9e170_p2" target="wnc1_s_wnc1_s71_wnc1_wnc1_sa11"> <start x="8172.0" y="688.5"/> <end x="8172.0" y="710.0"/> </arc> <arc class="catalysis" id="modif_20233173-8e3a-4b42-a65a-e733d205916b" source="wnc1_s_wnc1_s10_wnc1_wnc1_sa9" target="pr_915ba5d5-dc4a-4361-8484-738621b9e170"> <start x="8277.0" y="615.0"/> <end x="8177.0" y="673.5"/> </arc> <arc class="consumption" id="cons_691d647f-5308-4409-9645-6166b1746bdc" source="wnc1_s_wnc1_s74_wnc1_wnc1_sa58" target="pr_728d061c-27ff-4f80-84e9-fe3dce2f166d_p1"> <start x="8095.0" y="216.0"/> <next x="8129.5" y="286.0"/> <end x="8134.75" y="286.0"/> </arc> <arc class="consumption" id="cons_b7b62f7e-0c60-4cbd-8c08-da714d7f9ac5" source="wnc1_s_wnc1_s73_wnc1_wnc1_sa57" target="pr_728d061c-27ff-4f80-84e9-fe3dce2f166d_p1"> <start x="8118.0" y="287.0"/> <next x="8129.5" y="286.0"/> <end x="8134.75" y="286.0"/> </arc> <arc class="production" id="prod_93863707-1377-42c6-b1ff-f9da35dc472a" source="pr_728d061c-27ff-4f80-84e9-fe3dce2f166d_p2" target="wnc1_s_wnc1_s77_wnc1_wnc1_csa10"> <start x="8164.75" y="286.0"/> <end x="8166.0" y="286.0"/> </arc> <arc class="consumption" id="cons_8d26f120-ed90-45f2-9d8e-c609d2146d54" source="wnc1_s_wnc1_s77_wnc1_wnc1_csa10" target="pr_32342526-98b0-4d5d-b4c4-741c482e0c99_p1"> <start x="8216.0" y="346.0"/> <next x="8216.0" y="417.7503"/> <next x="8435.001" y="417.75003"/> <next x="8435.001" y="409.5"/> <end x="8435.017" y="415.00098"/> </arc> <arc class="consumption" id="cons_7e9919f8-7679-4133-bd15-2100e25f99fb" source="wnc1_s_wnc1_s89_wnc1_wnc1_csa11" target="pr_32342526-98b0-4d5d-b4c4-741c482e0c99_p1"> <start x="8435.0" y="385.0"/> <next x="8435.0" y="392.25"/> <next x="8435.0" y="392.25"/> <next x="8435.001" y="409.5"/> <end x="8435.017" y="415.00098"/> </arc> <arc class="production" id="prod_94e889ba-7aea-4165-a495-c7138545fca9" source="pr_32342526-98b0-4d5d-b4c4-741c482e0c99_p2" target="wnc1_s_wnc1_s91_wnc1_wnc1_csa12"> <start x="8435.017" y="385.00098"/> <next x="8435.025" y="394.50198"/> <next x="8741.984" y="394.99875"/> <end x="8742.0" y="385.5"/> </arc> <arc class="consumption" id="cons_7f5a5372-149d-46ba-8ee0-122e29caa1d5" source="wnc1_s_wnc1_s91_wnc1_wnc1_csa12" target="pr_12d345af-1941-49c3-9f82-6dc25005d4f0_p1"> <start x="8742.0" y="385.5"/> <end x="8741.5" y="429.25"/> </arc> <arc class="production" id="prod_8564f4d6-1e48-4ec7-986f-9f28bceb91b4" source="pr_12d345af-1941-49c3-9f82-6dc25005d4f0_p2" target="wnc1_s_wnc1_s104_wnc1_wnc1_sa94"> <start x="8741.5" y="459.25"/> <end x="8741.0" y="503.0"/> </arc> <arc class="inhibition" id="direct_ddc34b97-7084-46d3-95b2-fd0bcc53ee0a" source="wnc1_s_wnc1_s1143_wnc1_wnc1_csa3" target="wnc1_s_wnc1_s105_wnc1_wnc1_sa95"> <start x="7487.0" y="350.0"/> <end x="8701.0" y="570.0"/> </arc> <arc class="consumption" id="cons_850163a8-65ea-44c2-bf95-c7526f46eab2" source="wnc1_s_wnc1_s58_wnc1_wnc1_csa8" target="pr_af37ddf2-dcc6-4d6d-83a2-992243eaf42c_p1"> <start x="7806.5" y="504.0"/> <next x="7432.0" y="694.0"/> <end x="7352.5" y="720.0514"/> </arc> <arc class="consumption" id="cons_206274b8-a444-4b54-9c6f-dcf41766f9c2" source="wnc1_s_wnc1_s106_wnc1_wnc1_sa96" target="pr_af37ddf2-dcc6-4d6d-83a2-992243eaf42c_p1"> <start x="7330.0" y="632.0"/> <next x="7432.0" y="694.0"/> <end x="7352.5" y="720.0514"/> </arc> <arc class="production" id="prod_3b86783f-1d03-4bbc-ad1e-2d81e32b69ab" source="pr_af37ddf2-dcc6-4d6d-83a2-992243eaf42c_p2" target="wnc1_s_wnc1_s115_wnc1_wnc1_csa14"> <start x="7322.5" y="720.0514"/> <end x="7247.0" y="745.0"/> </arc> <arc class="consumption" id="cons_c52be709-081e-44ba-a820-8c1a8d76f02c" source="wnc1_s_wnc1_s1_wnc1_wnc1_sa1" target="pr_d2ddea26-2a08-4d75-9ac6-804a7182afcb_p1"> <start x="7918.0" y="553.0"/> <end x="7918.0" y="651.5"/> </arc> <arc class="production" id="prod_68c47f48-7201-4f69-9d6c-3adf12cf9686" source="pr_d2ddea26-2a08-4d75-9ac6-804a7182afcb_p2" target="wnc1_s_wnc1_s117_wnc1_wnc1_sa101"> <start x="7918.0" y="681.5"/> <end x="7918.0" y="780.0"/> </arc> <arc class="catalysis" id="modif_c6ff7c9d-f045-4fea-aa4b-e304472c2673" source="wnc1_s_wnc1_s120_wnc1_wnc1_csa15" target="pr_d2ddea26-2a08-4d75-9ac6-804a7182afcb"> <start x="7843.0" y="804.5"/> <end x="7913.0" y="666.5"/> </arc> <arc class="consumption" id="cons_27d5cea6-9331-4287-b25f-e4e069694405" source="wnc1_s_wnc1_s117_wnc1_wnc1_sa101" target="pr_1f6cc78a-a7c8-4944-976c-6aad890a3121_p1"> <start x="7918.0" y="820.0"/> <end x="7918.5" y="839.0"/> </arc> <arc class="production" id="prod_ca507f78-3a35-45de-8e07-62bf805a64c5" source="pr_1f6cc78a-a7c8-4944-976c-6aad890a3121_p2" target="wnc1_s_wnc1_s118_wnc1_wnc1_sa102"> <start x="7918.5" y="869.0"/> <end x="7919.0" y="888.0"/> </arc> <arc class="consumption" id="cons_6a513886-6807-480c-9d1a-44a7569f9889" source="wnc1_s_wnc1_s116_wnc1_wnc1_sa103" target="pr_b21af477-9737-4d7c-9b87-7b51d9098d12_p1"> <start x="7510.5" y="738.0"/> <next x="7649.75" y="768.0"/> <end x="7678.875" y="787.11646"/> </arc> <arc class="consumption" id="cons_bf79087e-8e0a-4056-af81-b95a7fae12c0" source="wnc1_s_wnc1_s1048_wnc1_wnc1_csa80" target="pr_b21af477-9737-4d7c-9b87-7b51d9098d12_p1"> <start x="7654.5" y="669.0"/> <next x="7649.75" y="768.0"/> <end x="7678.875" y="787.11646"/> </arc> <arc class="production" id="prod_c6888888-22d8-4779-8211-d260df32683b" source="pr_b21af477-9737-4d7c-9b87-7b51d9098d12_p2" target="wnc1_s_wnc1_s120_wnc1_wnc1_csa15"> <start x="7708.875" y="787.11646"/> <end x="7734.0" y="804.5"/> </arc> <arc class="consumption" id="cons_08ae9be7-0aaa-475d-89e7-94c5ebee28c2" source="wnc1_s_wnc1_s124_wnc1_wnc1_sa108" target="pr_134aa9ce-0abb-4ade-a655-88cf010ca847_p1"> <start x="7394.0" y="755.5"/> <end x="7394.0" y="770.71875"/> </arc> <arc class="production" id="prod_e2d4121c-3260-4328-8360-bbfde3429be3" source="pr_134aa9ce-0abb-4ade-a655-88cf010ca847_p2" target="wnc1_s_wnc1_s126_wnc1_wnc1_sa110"> <start x="7394.0" y="800.71875"/> <next x="7394.0" y="815.9375"/> <end x="7337.0" y="837.5"/> </arc> <arc class="production" id="prod_1743bcdb-59e4-4cde-8b64-a09783320878" source="pr_134aa9ce-0abb-4ade-a655-88cf010ca847_p2" target="wnc1_s_wnc1_s125_wnc1_wnc1_sa109"> <start x="7394.0" y="800.71875"/> <next x="7394.0" y="815.9375"/> <end x="7462.0" y="837.5"/> </arc> <arc class="catalysis" id="modif_e3fff4cd-1145-44e9-af6d-896b90d71b20" source="wnc1_s_wnc1_s115_wnc1_wnc1_csa14" target="pr_134aa9ce-0abb-4ade-a655-88cf010ca847"> <start x="7247.0" y="745.0"/> <end x="7389.0" y="785.71875"/> </arc> <arc class="catalysis" id="modif_8d2e3e48-45e9-4c82-b1e3-d2e8979b73d2" source="wnc1_s_wnc1_s278_wnc1_wnc1_csa34" target="pr_134aa9ce-0abb-4ade-a655-88cf010ca847"> <start x="7247.0" y="909.5"/> <end x="7389.0" y="790.71875"/> </arc> <arc class="catalysis" id="modif_355ffaae-a7db-4c6c-b19c-a0424a1cf94f" source="wnc1_s_wnc1_s288_wnc1_wnc1_csa36" target="pr_134aa9ce-0abb-4ade-a655-88cf010ca847"> <start x="7252.0" y="1052.5"/> <end x="7399.0" y="785.71875"/> </arc> <arc class="consumption" id="cons_a63eb106-98c7-43ef-aa85-7c4699650a79" source="wnc1_s_wnc1_s123_wnc1_wnc1_sa107" target="pr_2a539c7d-3b14-44d6-8c1a-742b003fbeb7_p1"> <start x="7589.0" y="978.0"/> <end x="7589.0" y="936.25"/> </arc> <arc class="production" id="prod_81ea59ca-0fbf-4f35-a0d1-4d51294d6208" source="pr_2a539c7d-3b14-44d6-8c1a-742b003fbeb7_p2" target="wnc1_s_wnc1_s119_wnc1_wnc1_sa104"> <start x="7589.0" y="906.25"/> <end x="7589.0" y="864.5"/> </arc> <arc class="catalysis" id="modif_9158c4d1-90e6-480a-8d93-87c9cbbc3779" source="wnc1_s_wnc1_s130_wnc1_wnc1_csa16" target="pr_2a539c7d-3b14-44d6-8c1a-742b003fbeb7"> <start x="7524.0" y="949.5"/> <end x="7584.0" y="916.25"/> </arc> <arc class="catalysis" id="modif_65ac1fdf-3f69-465e-9741-f5562ca8e67f" source="wnc1_s_wnc1_s136_wnc1_wnc1_csa17" target="pr_2a539c7d-3b14-44d6-8c1a-742b003fbeb7"> <start x="7521.0" y="1110.0"/> <end x="7584.0" y="926.25"/> </arc> <arc class="consumption" id="cons_82d87f09-6386-4f59-a072-9ba8b2171e3e" source="wnc1_s_wnc1_s127_wnc1_wnc1_sa111" target="pr_1d4896f9-4e4d-4d0a-98e3-e0f839ab068a_p1"> <start x="7391.0" y="949.0"/> <next x="7409.0" y="949.0"/> <end x="7417.5" y="964.3269"/> </arc> <arc class="consumption" id="cons_5531eb8b-1036-41e5-9ce4-c0dd1e657be7" source="wnc1_s_wnc1_s125_wnc1_wnc1_sa109" target="pr_1d4896f9-4e4d-4d0a-98e3-e0f839ab068a_p1"> <start x="7427.0" y="850.0"/> <next x="7409.0" y="949.0"/> <end x="7417.5" y="964.3269"/> </arc> <arc class="production" id="prod_c2a46597-5bae-4a34-a74c-aa8b6647572a" source="pr_1d4896f9-4e4d-4d0a-98e3-e0f839ab068a_p2" target="wnc1_s_wnc1_s130_wnc1_wnc1_csa16"> <start x="7417.5" y="934.3269"/> <end x="7422.0" y="949.5"/> </arc> <arc class="consumption" id="cons_2c0ad1f3-8ea3-41ea-8a9e-9722d21a1c35" source="wnc1_s_wnc1_s46_wnc1_wnc1_csa5" target="pr_4d789028-e74a-440f-a2d5-3e78e521d7d5_p1"> <start x="7903.0" y="386.0"/> <next x="7470.5" y="1018.40625"/> <end x="7470.5" y="1025.2031"/> </arc> <arc class="consumption" id="cons_4efac95e-a9ac-4bf0-b68c-0117029b92b7" source="wnc1_s_wnc1_s127_wnc1_wnc1_sa111" target="pr_4d789028-e74a-440f-a2d5-3e78e521d7d5_p1"> <start x="7351.0" y="979.0"/> <next x="7470.5" y="1018.40625"/> <end x="7470.5" y="1025.2031"/> </arc> <arc class="production" id="prod_e91d7e8c-86bc-4134-86d8-47ada20401c4" source="pr_4d789028-e74a-440f-a2d5-3e78e521d7d5_p2" target="wnc1_s_wnc1_s136_wnc1_wnc1_csa17"> <start x="7470.5" y="1055.2031"/> <end x="7470.5" y="1058.0"/> </arc> <arc class="consumption" id="cons_a10d63be-8db6-4154-b306-240d9150844c" source="wnc1_s_wnc1_s120_wnc1_wnc1_csa15" target="pr_67e2ce6a-f110-4925-b78c-cef67b15b5dc_p1"> <start x="7788.5" y="883.0"/> <end x="7789.75" y="890.5"/> </arc> <arc class="production" id="prod_5932aa12-dc9d-4a8d-ba52-272c9caf1c4b" source="pr_67e2ce6a-f110-4925-b78c-cef67b15b5dc_p2" target="wnc1_s_wnc1_s138_wnc1_wnc1_sa117"> <start x="7789.75" y="920.5"/> <end x="7791.0" y="928.0"/> </arc> <arc class="consumption" id="cons_d0130582-075e-4210-917b-886f6a370974" source="wnc1_s_wnc1_s46_wnc1_wnc1_csa5" target="pr_01c1c2c2-747f-4d65-8650-2dcdb42e9b46_p1"> <start x="7903.0" y="386.0"/> <next x="7808.75" y="1021.99994"/> <end x="7812.625" y="1030.3889"/> </arc> <arc class="consumption" id="cons_b9b7da84-020a-4ca6-99a3-03cee3734002" source="wnc1_s_wnc1_s141_wnc1_wnc1_csa18" target="pr_01c1c2c2-747f-4d65-8650-2dcdb42e9b46_p1"> <start x="7775.0" y="1022.0"/> <next x="7808.75" y="1021.99994"/> <end x="7812.625" y="1030.3889"/> </arc> <arc class="production" id="prod_581ac523-a3f1-41ed-8742-5b650993496c" source="pr_01c1c2c2-747f-4d65-8650-2dcdb42e9b46_p2" target="wnc1_s_wnc1_s150_wnc1_wnc1_csa19"> <start x="7842.625" y="1030.3889"/> <end x="7842.5" y="1037.0"/> </arc> <arc class="consumption" id="cons_25268408-0a81-4991-9789-67f568af33d4" source="wnc1_s_wnc1_s150_wnc1_wnc1_csa19" target="pr_92994762-12fe-430a-9aac-a0ec54ccdee1_p1"> <start x="7892.0" y="961.0"/> <end x="7902.009" y="954.5"/> </arc> <arc class="production" id="prod_40f6b403-d1b9-4bdc-b9ad-e38ebf36e58b" source="pr_92994762-12fe-430a-9aac-a0ec54ccdee1_p2" target="wnc1_s_wnc1_s118_wnc1_wnc1_sa102"> <start x="7902.009" y="924.5"/> <end x="7912.017" y="918.0"/> </arc> <arc class="consumption" id="cons_3a3afb8d-f4fb-41a2-8c9b-e4eabf9e5eac" source="wnc1_s_wnc1_s152_wnc1_wnc1_sa126" target="pr_14016a51-9638-430c-9151-724452c8974f_p1"> <start x="7202.0" y="1170.0"/> <end x="7202.0" y="1195.0"/> </arc> <arc class="production" id="prod_18baaec0-eda6-4c20-ba99-21c9a09f135a" source="pr_14016a51-9638-430c-9151-724452c8974f_p2" target="wnc1_s_wnc1_s154_wnc1_wnc1_sa127"> <start x="7202.0" y="1225.0"/> <end x="7202.0" y="1250.0"/> </arc> <arc class="catalysis" id="modif_c8b90eaa-6a99-4441-ae43-0d094605f3ac" source="wnc1_s_wnc1_s155_wnc1_wnc1_sa129" target="pr_14016a51-9638-430c-9151-724452c8974f"> <start x="7332.0" y="1210.0"/> <end x="7207.0" y="1210.0"/> </arc> <arc class="consumption" id="cons_05ce6065-8f97-4bae-a975-a1f1f58a8be0" source="wnc1_s_wnc1_s155_wnc1_wnc1_sa128" target="pr_102094c1-7b1b-40a3-adc4-1833766a00cc_p1"> <start x="7462.0" y="1210.0"/> <end x="7452.0" y="1210.0"/> </arc> <arc class="production" id="prod_d6f9021a-a0f1-4064-a802-20c3bd18d7fb" source="pr_102094c1-7b1b-40a3-adc4-1833766a00cc_p2" target="wnc1_s_wnc1_s155_wnc1_wnc1_sa129"> <start x="7422.0" y="1210.0"/> <end x="7412.0" y="1210.0"/> </arc> <arc class="catalysis" id="modif_6708275a-93e7-4b2e-a101-8f3d149cdc5a" source="wnc1_s_wnc1_s119_wnc1_wnc1_sa104" target="pr_102094c1-7b1b-40a3-adc4-1833766a00cc"> <start x="7583.7944" y="864.5"/> <end x="7442.0" y="1205.0"/> </arc> <arc class="catalysis" id="modif_e0e28d07-1a4e-4ea5-a6fb-1e42e3bc65c9" source="wnc1_s_wnc1_s126_wnc1_wnc1_sa110" target="pr_102094c1-7b1b-40a3-adc4-1833766a00cc"> <start x="7337.0" y="862.5"/> <end x="7432.0" y="1205.0"/> </arc> <arc class="consumption" id="cons_7ef01fb8-f887-4f07-b215-623173299231" source="wnc1_s_wnc1_s157_wnc1_wnc1_sa130" target="pr_634b2783-3226-464f-9ea8-18a834c38d39_p1"> <start x="7162.0" y="1342.0"/> <end x="7157.0" y="1342.0"/> </arc> <arc class="production" id="prod_08a26e24-474d-41a2-bc0d-7a2555cda468" source="pr_634b2783-3226-464f-9ea8-18a834c38d39_p2" target="wnc1_s_wnc1_s158_wnc1_wnc1_sa131"> <start x="7127.0" y="1342.0"/> <end x="7122.0" y="1342.0"/> </arc> <arc class="catalysis" id="modif_ee5413ca-e1bf-4cb6-94c9-1de06d9a8caf" source="wnc1_s_wnc1_s154_wnc1_wnc1_sa127" target="pr_634b2783-3226-464f-9ea8-18a834c38d39"> <start x="7202.0" y="1290.0"/> <end x="7142.0" y="1337.0"/> </arc> <arc class="consumption" id="cons_5b356892-120f-4ceb-a75d-bde2907781a0" source="wnc1_s_wnc1_s164_wnc1_wnc1_csa20" target="pr_cbae4977-d67e-4b01-9cd4-1a2169daf25d_p1"> <start x="7254.5" y="1590.0"/> <end x="7579.4956" y="1269.0"/> </arc> <arc class="production" id="prod_ad609566-1ec5-4822-9744-75d4284f4bae" source="pr_cbae4977-d67e-4b01-9cd4-1a2169daf25d_p2" target="wnc1_s_wnc1_s118_wnc1_wnc1_sa102"> <start x="7579.4956" y="1239.0"/> <end x="7904.491" y="918.0"/> </arc> <arc class="consumption" id="cons_ed6e5b57-256d-4aa3-8cba-c1f58f8a0f16" source="wnc1_s_wnc1_s158_wnc1_wnc1_sa131" target="pr_cd7fb350-582b-4518-ac2d-20100a92e85c_p1"> <start x="7082.0" y="1362.0"/> <next x="7084.6665" y="1442.0"/> <end x="7130.333" y="1474.5739"/> </arc> <arc class="consumption" id="cons_be349316-1fbe-486d-a273-bb6e74e6482f" source="wnc1_s_wnc1_s159_wnc1_wnc1_sa132" target="pr_cd7fb350-582b-4518-ac2d-20100a92e85c_p1"> <start x="7202.0" y="1425.0"/> <next x="7084.6665" y="1442.0"/> <end x="7130.333" y="1474.5739"/> </arc> <arc class="production" id="prod_f42a93d5-fc53-40d6-a065-a8f584b1b571" source="pr_cd7fb350-582b-4518-ac2d-20100a92e85c_p2" target="wnc1_s_wnc1_s164_wnc1_wnc1_csa20"> <start x="7160.333" y="1474.5739"/> <end x="7202.0" y="1505.0"/> </arc> <arc class="consumption" id="addreact_5d50ed45-6ee1-4685-8098-bf1228308d2b" source="wnc1_s_wnc1_s160_wnc1_wnc1_sa133" target="pr_cd7fb350-582b-4518-ac2d-20100a92e85c_p1"> <start x="7162.0" y="1465.0"/> <end x="7130.333" y="1474.5739"/> </arc> <arc class="consumption" id="cons_e3832aa2-0d84-496a-8e18-fdbc37d54111" source="wnc1_s_wnc1_s172_wnc1_wnc1_csa22" target="pr_1f58e1d3-69b2-45a8-af49-c7119dd5a44d_p1"> <start x="9220.8125" y="450.0"/> <next x="9298.0" y="448.0"/> <end x="9300.105" y="422.92188"/> </arc> <arc class="consumption" id="cons_13c7c920-3105-43cf-9e2c-670d3d819c97" source="wnc1_s_wnc1_s165_wnc1_wnc1_sa143" target="pr_1f58e1d3-69b2-45a8-af49-c7119dd5a44d_p1"> <start x="9533.0" y="410.0"/> <next x="9298.0" y="448.0"/> <end x="9300.105" y="422.92188"/> </arc> <arc class="production" id="prod_ccd80cef-0575-4fe3-b390-8dc3b5f9324a" source="pr_1f58e1d3-69b2-45a8-af49-c7119dd5a44d_p2" target="wnc1_s_wnc1_s1146_wnc1_wnc1_csa23"> <start x="9300.105" y="392.92188"/> <end x="9302.0" y="371.84375"/> </arc> <arc class="catalysis" id="modif_874acf67-4447-40cf-bb60-ed5be6a90772" source="wnc1_s_wnc1_s1145_wnc1_wnc1_csa25" target="pr_1f58e1d3-69b2-45a8-af49-c7119dd5a44d"> <start x="9102.297" y="371.84375"/> <end x="9295.112" y="407.65967"/> </arc> <arc class="consumption" id="cons_73ede266-25bc-421c-a267-e009416d05d4" source="wnc1_s_wnc1_s181_wnc1_wnc1_sa148" target="pr_05aee189-ba29-4a6c-b8b3-bfb1e26bc258_p1"> <start x="8972.0" y="210.0"/> <next x="9069.0" y="166.15625"/> <end x="9086.443" y="195.07812"/> </arc> <arc class="consumption" id="cons_d2ce8c5c-5d83-4415-b29e-f036fcda0748" source="wnc1_s_wnc1_s1146_wnc1_wnc1_csa23" target="pr_05aee189-ba29-4a6c-b8b3-bfb1e26bc258_p1"> <start x="9222.594" y="268.15625"/> <next x="9069.0" y="166.15625"/> <end x="9086.443" y="195.07812"/> </arc> <arc class="production" id="prod_e291ff4e-3c8e-4194-8947-9fccdc5168e3" source="pr_05aee189-ba29-4a6c-b8b3-bfb1e26bc258_p2" target="wnc1_s_wnc1_s1145_wnc1_wnc1_csa25"> <start x="9086.443" y="225.07812"/> <end x="9102.297" y="250.0"/> </arc> <arc class="consumption" id="addreact_4808ddb6-fcfd-40ea-bdc3-a1f94a90b854" source="wnc1_s_wnc1_s30_wnc1_wnc1_sa159" target="pr_05aee189-ba29-4a6c-b8b3-bfb1e26bc258_p1"> <start x="8952.518" y="357.5"/> <end x="9086.443" y="195.07812"/> </arc> <arc class="production" id="addprod_0df51cc5-1a38-49f3-b0f7-06f19b16deed" source="pr_05aee189-ba29-4a6c-b8b3-bfb1e26bc258_p2" target="wnc1_s_wnc1_s29_wnc1_wnc1_sa160"> <start x="9086.443" y="225.07812"/> <end x="9000.031" y="357.5"/> </arc> <arc class="consumption" id="cons_268cfdb4-d42a-42cf-b090-a455b68e8d63" source="wnc1_s_wnc1_s866_wnc1_wnc1_sa161" target="pr_89d20e6e-755f-4c0b-8a68-35baf0e31c00_p1"> <start x="9523.0" y="665.0"/> <end x="9432.5" y="662.5"/> </arc> <arc class="production" id="prod_bf385227-4c1a-4916-8621-09765203a984" source="pr_89d20e6e-755f-4c0b-8a68-35baf0e31c00_p2" target="wnc1_s_wnc1_s206_wnc1_wnc1_sa165"> <start x="9402.5" y="662.5"/> <end x="9312.0" y="660.0"/> </arc> <arc class="stimulation" id="modif_84d3ff32-d1e6-43ee-b237-0932ef36f162" source="wnc1_s_wnc1_s1148_wnc1_wnc1_csa26" target="pr_89d20e6e-755f-4c0b-8a68-35baf0e31c00"> <start x="8962.0" y="530.0"/> <end x="9417.618" y="657.5014"/> </arc> <arc class="consumption" id="cons_2af514e2-ad99-49e2-8634-86f860e868d7" source="wnc1_s_wnc1_s1145_wnc1_wnc1_csa25" target="pr_0fc603b2-f2b2-4282-be1c-bb959ef2c42a_p1"> <start x="9102.297" y="371.84375"/> <end x="9096.59" y="373.34375"/> </arc> <arc class="production" id="prod_457d6545-64ea-4fe3-94a5-9280e7c4eb90" source="pr_0fc603b2-f2b2-4282-be1c-bb959ef2c42a_p2" target="wnc1_s_wnc1_s1148_wnc1_wnc1_csa26"> <start x="9096.59" y="403.34375"/> <next x="9090.884" y="404.84375"/> <end x="8962.0" y="470.0"/> </arc> <arc class="production" id="prod_e7e63ca7-5697-4b4c-a2db-be9dd20fcf03" source="pr_0fc603b2-f2b2-4282-be1c-bb959ef2c42a_p2" target="wnc1_s_wnc1_s165_wnc1_wnc1_sa143"> <start x="9096.59" y="403.34375"/> <next x="9090.884" y="404.84375"/> <end x="9533.0" y="400.73166"/> </arc> <arc class="production" id="addprod_66a8a9c8-a81b-4864-9883-638ae019c5b9" source="pr_0fc603b2-f2b2-4282-be1c-bb959ef2c42a_p2" target="wnc1_s_wnc1_s46_wnc1_wnc1_csa5"> <start x="9096.59" y="403.34375"/> <end x="7948.0" y="361.0"/> </arc> <arc class="production" id="addprod_eacc7f5d-3a31-4d41-8db7-3941c1848472" source="pr_0fc603b2-f2b2-4282-be1c-bb959ef2c42a_p2" target="wnc1_s_wnc1_s181_wnc1_wnc1_sa148"> <start x="9096.59" y="403.34375"/> <end x="8980.495" y="222.5"/> </arc> <arc class="consumption" id="cons_53444da9-4968-4ef8-aa60-3dad909fdeb9" source="wnc1_s_wnc1_s220_wnc1_wnc1_sa172" target="pr_e5b2e874-c62d-43bf-b739-701544741530_p1"> <start x="9142.0" y="632.5"/> <end x="9142.0" y="645.0"/> </arc> <arc class="production" id="prod_2ec6755e-903b-4db2-b6bf-4920c2f69e15" source="pr_e5b2e874-c62d-43bf-b739-701544741530_p2" target="wnc1_s_wnc1_s221_wnc1_wnc1_sa173"> <start x="9142.0" y="675.0"/> <end x="9142.0" y="687.5"/> </arc> <arc class="catalysis" id="modif_82558be5-04b5-4f9d-9204-2fbd3a61f11a" source="wnc1_s_wnc1_s206_wnc1_wnc1_sa165" target="pr_e5b2e874-c62d-43bf-b739-701544741530"> <start x="9232.0" y="660.0"/> <end x="9147.0" y="660.0"/> </arc> <arc class="consumption" id="cons_354b66aa-914b-4b1a-8fc6-fc9092007a77" source="wnc1_s1088_wnc1_wnc1_csa81" target="pr_3e9841d1-e84a-4924-90b7-cbc15acb8578_p1"> <start x="8958.5" y="755.0"/> <end x="8958.0" y="757.5"/> </arc> <arc class="production" id="prod_bd2989b7-3599-4364-9170-5ffcb8089e71" source="pr_3e9841d1-e84a-4924-90b7-cbc15acb8578_p2" target="wnc1_s1088_wnc1_wnc1_csa82"> <start x="8958.0" y="727.5"/> <end x="8957.5" y="730.0"/> </arc> <arc class="catalysis" id="modif_9a14cf96-5c07-4c6f-90db-cb8fb505f3b6" source="wnc1_s_wnc1_s221_wnc1_wnc1_sa173" target="pr_3e9841d1-e84a-4924-90b7-cbc15acb8578"> <start x="9107.0" y="708.2708"/> <end x="8962.996" y="742.3002"/> </arc> <arc class="consumption" id="cons_6de54c12-adb1-4c05-a21e-026388661232" source="wnc1_s_wnc1_s165_wnc1_wnc1_sa143" target="pr_418f4656-efc5-4138-bd45-1cc6899fd9a4_p1"> <start x="9573.0" y="440.0"/> <end x="9573.369" y="439.0"/> </arc> <arc class="production" id="prod_a061ba80-dfe1-44c7-8cbb-17afdd4ac482" source="pr_418f4656-efc5-4138-bd45-1cc6899fd9a4_p2" target="wnc1_s_wnc1_s865_wnc1_wnc1_sa176"> <start x="9573.369" y="469.0"/> <end x="9573.737" y="468.0"/> </arc> <arc class="catalysis" id="modif_2e2a1b2e-3d16-4418-a5b7-060e70af431e" source="wnc1_s_wnc1_s225_wnc1_wnc1_sa177" target="pr_418f4656-efc5-4138-bd45-1cc6899fd9a4"> <start x="9022.0" y="590.0"/> <end x="9568.239" y="449.13318"/> </arc> <arc class="catalysis" id="modif_66c1c1a3-5d69-4aff-ada0-db01b37a9ef0" source="wnc1_s1088_wnc1_wnc1_csa82" target="pr_418f4656-efc5-4138-bd45-1cc6899fd9a4"> <start x="9019.0" y="683.0"/> <end x="9568.502" y="459.1297"/> </arc> <arc class="consumption" id="cons_0d551faa-1d07-4685-ad0b-4334f77369d2" source="wnc1_s_wnc1_s865_wnc1_wnc1_sa176" target="pr_7c34e562-bee4-41cb-b3c6-977c50a31392_p1"> <start x="9574.0" y="518.0"/> <next x="9312.0" y="520.0"/> <end x="9376.75" y="550.25885"/> </arc> <arc class="consumption" id="cons_be7fbcf3-ffa3-4e75-b444-007aa5165e15" source="wnc1_s_wnc1_s172_wnc1_wnc1_csa22" target="pr_7c34e562-bee4-41cb-b3c6-977c50a31392_p1"> <start x="9142.0" y="473.6875"/> <next x="9312.0" y="520.0"/> <end x="9376.75" y="550.25885"/> </arc> <arc class="production" id="prod_ec084a27-f00f-4b01-840e-2f5b991d93f5" source="pr_7c34e562-bee4-41cb-b3c6-977c50a31392_p2" target="wnc1_s_wnc1_s1147_wnc1_wnc1_csa27"> <start x="9406.75" y="550.25885"/> <end x="9467.5" y="579.0"/> </arc> <arc class="catalysis" id="modif_188a249b-881c-44e2-bace-ba2ddf1c59ae" source="wnc1_s_wnc1_s865_wnc1_wnc1_sa176" target="pr_7c34e562-bee4-41cb-b3c6-977c50a31392"> <start x="9534.0" y="488.0"/> <next x="9389.311" y="489.47205"/> <end x="9389.977" y="554.93365"/> </arc> <arc class="consumption" id="addreact_f5c1be12-86d8-45eb-b6bc-a4d5e1f4247d" source="wnc1_s_wnc1_s30_wnc1_wnc1_sa159" target="pr_7c34e562-bee4-41cb-b3c6-977c50a31392_p1"> <start x="8954.5" y="375.0193"/> <end x="9376.75" y="550.25885"/> </arc> <arc class="production" id="addprod_92b7d7bb-2968-4448-a2d6-36c3a16416dc" source="pr_7c34e562-bee4-41cb-b3c6-977c50a31392_p2" target="wnc1_s_wnc1_s29_wnc1_wnc1_sa160"> <start x="9406.75" y="550.25885"/> <end x="9004.5" y="375.60397"/> </arc> <arc class="production" id="addprod_dada741f-f6bd-4da0-884d-6da780577ae8" source="pr_7c34e562-bee4-41cb-b3c6-977c50a31392_p2" target="wnc1_s_wnc1_s865_wnc1_wnc1_sa181"> <start x="9406.75" y="550.25885"/> <end x="9549.655" y="694.0"/> </arc> <arc class="consumption" id="cons_44ff71c1-39ef-44de-82da-d62f98a1b184" source="wnc1_s_wnc1_s1147_wnc1_wnc1_csa27" target="pr_7181f536-9a4b-430b-a836-f925544fcb9c_p1"> <start x="9467.5" y="579.0"/> <end x="9370.75" y="540.1945"/> </arc> <arc class="production" id="prod_06da162c-a071-47d0-9ec9-bf665fcdc0e2" source="pr_7181f536-9a4b-430b-a836-f925544fcb9c_p2" target="wnc1_s_wnc1_s1148_wnc1_wnc1_csa26"> <start x="9340.75" y="540.1945"/> <next x="9244.0" y="501.389"/> <end x="8997.0" y="500.0"/> </arc> <arc class="production" id="prod_6c098a12-b9d3-4780-a0fe-f6fa831fcf06" source="pr_7181f536-9a4b-430b-a836-f925544fcb9c_p2" target="wnc1_s_wnc1_s172_wnc1_wnc1_csa22"> <start x="9340.75" y="540.1945"/> <next x="9244.0" y="501.389"/> <end x="9220.8125" y="450.0"/> </arc> <arc class="consumption" id="cons_294f409f-3201-4673-b8b4-8f5d3301fbee" source="wnc1_s_wnc1_s165_wnc1_wnc1_sa143" target="pr_d51ef16b-cd68-484d-b7f2-cd00e1c15604_p1"> <start x="9573.0" y="440.0"/> <next x="9462.25" y="749.99994"/> <end x="9500.625" y="763.50604"/> </arc> <arc class="consumption" id="cons_85fa8a06-fbca-455c-8342-e395f8586dd0" source="wnc1_s_wnc1_s232_wnc1_wnc1_sa184" target="pr_d51ef16b-cd68-484d-b7f2-cd00e1c15604_p1"> <start x="9567.5" y="757.0"/> <next x="9462.25" y="749.99994"/> <end x="9500.625" y="763.50604"/> </arc> <arc class="production" id="prod_8c0b24a3-1413-4612-ab8b-c5250d9c9f9f" source="pr_d51ef16b-cd68-484d-b7f2-cd00e1c15604_p2" target="wnc1_s_wnc1_s233_wnc1_wnc1_csa28"> <start x="9530.625" y="763.50604"/> <end x="9565.0" y="776.0"/> </arc> <arc class="consumption" id="cons_85ef28c3-3a4e-4f2c-bc98-40360455343b" source="wnc1_s_wnc1_s233_wnc1_wnc1_csa28" target="pr_b6653469-c1b8-4cba-a8ca-303d9848c5e5_p1"> <start x="9515.0" y="826.0"/> <end x="9161.848" y="679.5"/> </arc> <arc class="production" id="prod_aec69701-f317-488e-b397-93b000bf13e2" source="pr_b6653469-c1b8-4cba-a8ca-303d9848c5e5_p2" target="wnc1_s_wnc1_s104_wnc1_wnc1_sa94"> <start x="9131.848" y="679.5"/> <end x="8778.694" y="533.0"/> </arc> <arc class="consumption" id="cons_f1e256b4-9b6c-4805-a06e-b650c51bd5c8" source="wnc1_s_wnc1_s239_wnc1_wnc1_sa188" target="pr_ec672bd5-35af-46b0-9176-13cf29178a2c_p1"> <start x="9631.0" y="1024.0"/> <next x="9569.0" y="1039.0"/> <end x="9561.797" y="1044.5"/> </arc> <arc class="consumption" id="cons_976b8050-05ba-4dc8-9807-428732a627f8" source="wnc1_s_wnc1_s1152_wnc1_wnc1_csa30" target="pr_ec672bd5-35af-46b0-9176-13cf29178a2c_p1"> <start x="9571.0" y="994.0"/> <next x="9569.0" y="1039.0"/> <end x="9561.797" y="1044.5"/> </arc> <arc class="production" id="prod_3157d695-b5f4-42d0-b808-e2e9eb31e4cc" source="pr_ec672bd5-35af-46b0-9176-13cf29178a2c_p2" target="wnc1_s_wnc1_s240_wnc1_wnc1_csa29"> <start x="9561.797" y="1074.5"/> <end x="9556.0" y="1076.0"/> </arc> <arc class="consumption" id="addreact_b3286c76-58a3-496b-834f-e5cfea89ccf7" source="wnc1_s_wnc1_s30_wnc1_wnc1_sa197" target="pr_ec672bd5-35af-46b0-9176-13cf29178a2c_p1"> <start x="9294.5" y="1002.50037"/> <end x="9561.797" y="1044.5"/> </arc> <arc class="production" id="addprod_52ae6ee6-c552-4a63-bae5-e8d3729df779" source="pr_ec672bd5-35af-46b0-9176-13cf29178a2c_p2" target="wnc1_s_wnc1_s29_wnc1_wnc1_sa196"> <start x="9561.797" y="1074.5"/> <end x="9294.5" y="1079.2284"/> </arc> <arc class="consumption" id="cons_955bfc4a-b2f5-47c0-b949-aea8b62b33b6" source="wnc1_s_wnc1_s240_wnc1_wnc1_csa29" target="pr_02ee599f-4c20-490d-90d2-6ae9c4dadc92_p1"> <start x="9481.0" y="1131.0"/> <end x="9450.5" y="1126.6895"/> </arc> <arc class="production" id="prod_f80186bf-643d-4f5f-addc-e66a3142bd8f" source="pr_02ee599f-4c20-490d-90d2-6ae9c4dadc92_p2" target="wnc1_s_wnc1_s46_wnc1_wnc1_csa5"> <start x="9420.5" y="1126.6895"/> <next x="9390.0" y="1122.3789"/> <end x="7948.0" y="361.0"/> </arc> <arc class="production" id="prod_37f7b6a3-7fbd-4340-be0e-ccd7365f5dee" source="pr_02ee599f-4c20-490d-90d2-6ae9c4dadc92_p2" target="wnc1_s_wnc1_s259_wnc1_wnc1_csa31"> <start x="9420.5" y="1126.6895"/> <next x="9390.0" y="1122.3789"/> <end x="9232.0" y="1182.5"/> </arc> <arc class="consumption" id="cons_0ac915cd-02d0-402f-a4f5-10e536ddf2af" source="wnc1_s_wnc1_s259_wnc1_wnc1_csa31" target="pr_1f8aaf0f-abcd-403d-8c50-b7757f63b6e4_p1"> <start x="9202.0" y="1145.0"/> <end x="9202.0" y="1126.25"/> </arc> <arc class="production" id="prod_7b7399e2-aaa7-4a7b-8fcf-321465e5d889" source="pr_1f8aaf0f-abcd-403d-8c50-b7757f63b6e4_p2" target="wnc1_s_wnc1_s264_wnc1_wnc1_csa32"> <start x="9202.0" y="1096.25"/> <end x="9202.0" y="1077.5"/> </arc> <arc class="catalysis" id="modif_a4c94b3c-a320-4ce3-aee6-c186b0cdd15d" source="wnc1_s_wnc1_s269_wnc1_wnc1_sa209" target="pr_1f8aaf0f-abcd-403d-8c50-b7757f63b6e4"> <start x="9141.0" y="1111.0"/> <end x="9197.0" y="1111.25"/> </arc> <arc class="production" id="addprod_ce1fe955-d36e-4cc5-8611-79d85fb56224" source="pr_1f8aaf0f-abcd-403d-8c50-b7757f63b6e4_p2" target="wnc1_s_wnc1_s268_wnc1_wnc1_sa208"> <start x="9202.0" y="1096.25"/> <end x="9229.5" y="1094.5312"/> </arc> <arc class="stimulation" id="direct_ee56228a-b563-45ef-ba1a-eb4eb1394678" source="wnc1_s_wnc1_s72_wnc1_wnc1_sa7" target="wnc1_s_wnc1_s9_wnc1_wnc1_sa8"> <start x="8212.0" y="933.0979"/> <end x="8260.5" y="933.2716"/> </arc> <arc class="consumption" id="cons_1a6154d3-cb2f-4f70-ad5d-4c1e2079d458" source="wnc1_s_wnc1_s259_wnc1_wnc1_csa31" target="pr_ce0fde21-eaa2-4612-8e48-eae58dff7f75_p1"> <start x="9172.0" y="1182.5"/> <end x="8530.5" y="819.0"/> </arc> <arc class="production" id="prod_dc475918-e5de-420f-b020-dba6803c4881" source="pr_ce0fde21-eaa2-4612-8e48-eae58dff7f75_p2" target="wnc1_s_wnc1_s58_wnc1_wnc1_csa8"> <start x="8500.5" y="819.0"/> <end x="7859.0" y="455.5"/> </arc> <arc class="consumption" id="cons_8e10a5af-5a53-4321-8dbb-5e1d429e3c06" source="wnc1_s_wnc1_s1148_wnc1_wnc1_csa26" target="pr_f45080f4-3bfc-48cb-be34-59a32b0c7a8b_p1"> <start x="8962.0" y="470.0"/> <next x="8882.0" y="450.0"/> <end x="8959.594" y="450.0"/> </arc> <arc class="consumption" id="cons_f0716259-fc7a-4e11-bda5-432f2026f84f" source="wnc1_s_wnc1_s46_wnc1_wnc1_csa5" target="pr_f45080f4-3bfc-48cb-be34-59a32b0c7a8b_p1"> <start x="7948.0" y="361.0"/> <next x="8882.0" y="450.0"/> <end x="8959.594" y="450.0"/> </arc> <arc class="production" id="prod_f90a5158-860e-43d7-9ca7-f2a9418f1c76" source="pr_f45080f4-3bfc-48cb-be34-59a32b0c7a8b_p2" target="wnc1_s_wnc1_s172_wnc1_wnc1_csa22"> <start x="8989.594" y="450.0"/> <end x="9063.1875" y="450.0"/> </arc> <arc class="consumption" id="cons_77eedacd-86ac-4010-b036-b0c9783bead2" source="wnc1_s_wnc1_s269_wnc1_wnc1_sa209" target="pr_a2c796dc-e73f-4efe-8701-0722350ee0e4_p1"> <start x="9101.0" y="1091.0"/> <end x="9101.0" y="1080.5"/> </arc> <arc class="production" id="prod_e454c2e5-76fc-4282-ae4c-ec25c6ada5a8" source="pr_a2c796dc-e73f-4efe-8701-0722350ee0e4_p2" target="wnc1_s_wnc1_s271_wnc1_wnc1_sa210"> <start x="9101.0" y="1050.5"/> <end x="9101.0" y="1040.0"/> </arc> <arc class="consumption" id="cons_708e57e8-9279-4024-b9d5-a3091bf156b9" source="wnc1_s_wnc1_s271_wnc1_wnc1_sa210" target="pr_cf3ee625-8b29-4af0-8965-3ba525256afd_p1"> <start x="9101.0" y="1000.0"/> <next x="9102.0" y="940.0"/> <end x="9102.0" y="940.5"/> </arc> <arc class="consumption" id="cons_7600be05-8b81-410b-88b0-dd831b864101" source="wnc1_s_wnc1_s272_wnc1_wnc1_sa211" target="pr_cf3ee625-8b29-4af0-8965-3ba525256afd_p1"> <start x="9022.0" y="940.0"/> <next x="9102.0" y="940.0"/> <end x="9102.0" y="940.5"/> </arc> <arc class="production" id="prod_072121cf-9af0-4249-9050-bfe6ddd7dd03" source="pr_cf3ee625-8b29-4af0-8965-3ba525256afd_p2" target="wnc1_s_wnc1_s275_wnc1_wnc1_csa33"> <start x="9102.0" y="910.5"/> <end x="9102.0" y="915.0"/> </arc> <arc class="consumption" id="cons_8c350d54-c57a-4112-92b3-0eba06f43c11" source="wnc1_s_wnc1_s46_wnc1_wnc1_csa5" target="pr_a126cfa1-1eeb-4087-89f8-5d36119c70c6_p1"> <start x="7903.0" y="386.0"/> <next x="7572.0" y="650.0"/> <end x="7422.5" y="793.36804"/> </arc> <arc class="consumption" id="cons_94eb66d1-85e3-4411-9a43-0bdf42fff1eb" source="wnc1_s_wnc1_s106_wnc1_wnc1_sa96" target="pr_a126cfa1-1eeb-4087-89f8-5d36119c70c6_p1"> <start x="7370.0" y="612.0"/> <next x="7572.0" y="650.0"/> <end x="7422.5" y="793.36804"/> </arc> <arc class="production" id="prod_043bf2a3-e4ce-4350-91db-f88d7ebb5925" source="pr_a126cfa1-1eeb-4087-89f8-5d36119c70c6_p2" target="wnc1_s_wnc1_s278_wnc1_wnc1_csa34"> <start x="7392.5" y="793.36804"/> <end x="7247.0" y="933.25"/> </arc> <arc class="consumption" id="cons_1b196b35-e926-4663-b2d3-d18536a7cdf3" source="wnc1_s_wnc1_s286_wnc1_wnc1_csa35" target="pr_1e0d86e5-91ac-4da3-9436-051f568c3f77_p1"> <start x="7342.0" y="520.0"/> <next x="7342.0" y="684.0"/> <end x="7296.5117" y="855.25"/> </arc> <arc class="consumption" id="cons_fe14b537-80ed-4def-a06c-ee8a99489159" source="wnc1_s_wnc1_s106_wnc1_wnc1_sa96" target="pr_1e0d86e5-91ac-4da3-9436-051f568c3f77_p1"> <start x="7330.0" y="632.0"/> <next x="7342.0" y="684.0"/> <end x="7296.5117" y="855.25"/> </arc> <arc class="production" id="prod_d6d0b2d8-6027-4d35-a51c-7066498cba4e" source="pr_1e0d86e5-91ac-4da3-9436-051f568c3f77_p2" target="wnc1_s_wnc1_s288_wnc1_wnc1_csa36"> <start x="7296.5117" y="885.25"/> <end x="7252.0" y="1052.5"/> </arc> <arc class="consumption" id="cons_3a37874f-5308-4708-b599-3fabe7501070" source="wnc1_s_wnc1_s291_wnc1_wnc1_sa224" target="pr_eab79457-d8ad-4a1c-9299-9c65af664f8a_p1"> <start x="9571.0" y="1448.0"/> <next x="9485.0" y="1520.0"/> <end x="9479.133" y="1537.0"/> </arc> <arc class="consumption" id="cons_ae0e2055-8de9-49e4-bb75-4d4ea52514e3" source="wnc1_s_wnc1_s1152_wnc1_wnc1_csa30" target="pr_eab79457-d8ad-4a1c-9299-9c65af664f8a_p1"> <start x="9606.0" y="994.0"/> <next x="9485.0" y="1520.0"/> <end x="9479.133" y="1537.0"/> </arc> <arc class="production" id="prod_36598a3d-e9ab-45cd-8ad7-8da757feb910" source="pr_eab79457-d8ad-4a1c-9299-9c65af664f8a_p2" target="wnc1_s_wnc1_s324_wnc1_wnc1_csa39"> <start x="9479.133" y="1567.0"/> <end x="9474.0" y="1580.0"/> </arc> <arc class="consumption" id="addreact_1f0aa4f7-47a7-4d24-9ec7-463573252219" source="wnc1_s_wnc1_s239_wnc1_wnc1_sa188" target="pr_eab79457-d8ad-4a1c-9299-9c65af664f8a_p1"> <start x="9631.0" y="1024.0"/> <end x="9479.133" y="1537.0"/> </arc> <arc class="consumption" id="addreact_e5d63207-4fe8-4a58-a599-f6f62e386a06" source="wnc1_s_wnc1_s30_wnc1_wnc1_sa245" target="pr_eab79457-d8ad-4a1c-9299-9c65af664f8a_p1"> <start x="9322.5" y="1496.4595"/> <end x="9479.133" y="1537.0"/> </arc> <arc class="consumption" id="addreact_0b3a805b-5652-434a-889c-e38d3e7f359d" source="wnc1_s_wnc1_s321_wnc1_wnc1_sa251" target="pr_eab79457-d8ad-4a1c-9299-9c65af664f8a_p1"> <start x="9346.444" y="1472.0"/> <end x="9479.133" y="1537.0"/> </arc> <arc class="consumption" id="addreact_f48bc5d7-112a-4210-b7b2-b027715d32f4" source="wnc1_s_wnc1_s292_wnc1_wnc1_sa225" target="pr_eab79457-d8ad-4a1c-9299-9c65af664f8a_p1"> <start x="9573.0" y="1497.0"/> <end x="9479.133" y="1537.0"/> </arc> <arc class="consumption" id="addreact_f33ef2d3-e403-49e7-8a74-60d3c54053e8" source="wnc1_s_wnc1_s380_wnc1_wnc1_sa291" target="pr_eab79457-d8ad-4a1c-9299-9c65af664f8a_p1"> <start x="9569.0" y="1385.0"/> <end x="9479.133" y="1537.0"/> </arc> <arc class="consumption" id="addreact_270e1108-ce84-42e9-aa5e-27e5a1555e35" source="wnc1_s_wnc1_s398_wnc1_wnc1_csa48" target="pr_eab79457-d8ad-4a1c-9299-9c65af664f8a_p1"> <start x="9525.0" y="1317.0"/> <end x="9479.133" y="1537.0"/> </arc> <arc class="consumption" id="addreact_707650bd-e06b-4830-aeed-a633508f50cf" source="wnc1_s_wnc1_s909_wnc1_wnc1_sa611" target="pr_eab79457-d8ad-4a1c-9299-9c65af664f8a_p1"> <start x="9529.0" y="1545.0806"/> <end x="9479.133" y="1537.0"/> </arc> <arc class="production" id="addprod_76ea6d3d-bc94-407b-9b53-58f7acc070d8" source="pr_eab79457-d8ad-4a1c-9299-9c65af664f8a_p2" target="wnc1_s_wnc1_s29_wnc1_wnc1_sa246"> <start x="9479.133" y="1567.0"/> <end x="9319.5" y="1563.996"/> </arc> <arc class="consumption" id="cons_151f2b18-6ce6-447f-8793-38249efd6591" source="wnc1_s_wnc1_s324_wnc1_wnc1_csa39" target="pr_fcc832e6-ffde-4e25-80f1-93820e806f67_p1"> <start x="9474.0" y="1748.0"/> <end x="9471.959" y="1752.5"/> </arc> <arc class="production" id="prod_abc4ea8e-1041-42bc-9653-131516bd1a69" source="pr_fcc832e6-ffde-4e25-80f1-93820e806f67_p2" target="wnc1_s_wnc1_s259_wnc1_wnc1_csa31"> <start x="9471.959" y="1782.5"/> <next x="9469.919" y="1787.0"/> <end x="9202.0" y="1220.0"/> </arc> <arc class="production" id="prod_8ae126a3-be8c-4f16-9280-6660e1d7287f" source="pr_fcc832e6-ffde-4e25-80f1-93820e806f67_p2" target="wnc1_s_wnc1_s329_wnc1_wnc1_csa40"> <start x="9471.959" y="1782.5"/> <next x="9469.919" y="1787.0"/> <end x="9471.5" y="1833.0"/> </arc> <arc class="production" id="addprod_fd7d8abc-e18a-47c9-b3b0-9d8ef6d5384d" source="pr_fcc832e6-ffde-4e25-80f1-93820e806f67_p2" target="wnc1_s_wnc1_s46_wnc1_wnc1_csa5"> <start x="9471.959" y="1782.5"/> <end x="7948.0" y="361.0"/> </arc> <arc class="consumption" id="cons_50e53798-3034-4ced-9f7f-20541a154322" source="wnc1_s_wnc1_s13_wnc1_wnc1_sa256" target="pr_014b210f-de8c-45b3-a695-94ffd545951c_p1"> <start x="9218.0" y="1884.0"/> <end x="9218.0" y="1895.0"/> </arc> <arc class="production" id="prod_74ffe9ad-55ae-456a-a312-9cc13e7e68c2" source="pr_014b210f-de8c-45b3-a695-94ffd545951c_p2" target="wnc1_s_wnc1_s331_wnc1_wnc1_sa257"> <start x="9218.0" y="1925.0"/> <end x="9218.0" y="1936.0"/> </arc> <arc class="catalysis" id="modif_95cad909-f78e-426f-90b9-23434172b56a" source="wnc1_s_wnc1_s155_wnc1_wnc1_sa129" target="pr_014b210f-de8c-45b3-a695-94ffd545951c"> <start x="7372.0" y="1230.0"/> <end x="9213.0" y="1910.0"/> </arc> <arc class="consumption" id="cons_d6288777-1072-4a64-86b0-d099babb0863" source="wnc1_s_wnc1_s329_wnc1_wnc1_csa40" target="pr_3002034b-55e7-4355-beee-96dbaaf003c1_p1"> <start x="9471.5" y="2001.0"/> <next x="9469.5" y="2031.3264"/> <end x="9472.272" y="2036.6631"/> </arc> <arc class="consumption" id="cons_24475ae7-cc2d-462e-a324-166852e8e887" source="wnc1_s_wnc1_s387_wnc1_wnc1_csa46" target="pr_3002034b-55e7-4355-beee-96dbaaf003c1_p1"> <start x="9203.0" y="2083.0"/> <next x="9469.5" y="2031.3264"/> <end x="9472.272" y="2036.6631"/> </arc> <arc class="production" id="prod_a49a6260-0247-4a97-ba01-398ff348e682" source="pr_3002034b-55e7-4355-beee-96dbaaf003c1_p2" target="wnc1_s_wnc1_s337_wnc1_wnc1_csa42"> <start x="9472.272" y="2066.663"/> <end x="9474.5" y="2068.0"/> </arc> <arc class="inhibition" id="direct_4ff93262-b08a-41d6-a81b-4a27752f37a8" source="wnc1_s_wnc1_s366_wnc1_wnc1_csa45" target="wnc1_s_wnc1_s104_wnc1_wnc1_sa94"> <start x="7920.25" y="2369.0"/> <end x="8728.5" y="533.0"/> </arc> <arc class="consumption" id="cons_03cd6bf9-b5d5-492b-8144-3e637f6bce2c" source="wnc1_s_wnc1_s386_wnc1_wnc1_sa297" target="pr_a178de00-1d7f-4779-bfc8-7794defe12e5_p1"> <start x="9085.0" y="1975.0"/> <next x="9153.0" y="2000.7449"/> <end x="9153.0" y="1998.8724"/> </arc> <arc class="consumption" id="cons_4d15dc89-6ef1-4017-aeba-21e54411c9d5" source="wnc1_s_wnc1_s331_wnc1_wnc1_sa257" target="pr_a178de00-1d7f-4779-bfc8-7794defe12e5_p1"> <start x="9218.0" y="1976.0"/> <next x="9153.0" y="2000.7449"/> <end x="9153.0" y="1998.8724"/> </arc> <arc class="production" id="prod_1f5a5b11-bcb3-4e2e-94eb-cc46153889b3" source="pr_a178de00-1d7f-4779-bfc8-7794defe12e5_p2" target="wnc1_s_wnc1_s387_wnc1_wnc1_csa46"> <start x="9153.0" y="2028.8724"/> <end x="9153.0" y="2023.0"/> </arc> <arc class="inhibition" id="direct_794bee72-20e6-42e1-a226-7678b5b5e953" source="wnc1_s_wnc1_s396_wnc1_wnc1_csa47" target="wnc1_s_wnc1_s104_wnc1_wnc1_sa94"> <start x="8897.0" y="1279.0"/> <end x="8741.0" y="533.0"/> </arc> <arc class="consumption" id="cons_b68bf327-cc62-4ce2-9a37-7b7826b1dbee" source="wnc1_s_wnc1_s409_wnc1_wnc1_sa317" target="pr_5d085f47-5842-45d4-8177-b55c27a7ab32_p1"> <start x="8186.5" y="1196.0"/> <end x="8290.0" y="1196.0"/> </arc> <arc class="production" id="prod_fe701d2c-b5a6-4edf-bd71-9e5bcfa9eee6" source="pr_5d085f47-5842-45d4-8177-b55c27a7ab32_p2" target="wnc1_s_wnc1_s410_wnc1_wnc1_sa318"> <start x="8320.0" y="1196.0"/> <end x="8423.5" y="1196.0"/> </arc> <arc class="catalysis" id="modif_040d7552-30d8-49f3-98be-802ce8828fda" source="wnc1_s_wnc1_s411_wnc1_wnc1_sa319" target="pr_5d085f47-5842-45d4-8177-b55c27a7ab32"> <start x="8304.0" y="1262.0"/> <end x="8305.0" y="1201.0"/> </arc> <arc class="consumption" id="cons_228d6d94-f80f-4f23-9ce2-6d0457e109a4" source="wnc1_s_wnc1_s410_wnc1_wnc1_sa318" target="pr_3819ccd2-dff9-4b60-8740-cbda7edf990e_p1"> <start x="8503.5" y="1196.0"/> <end x="8660.25" y="1267.5"/> </arc> <arc class="production" id="prod_539dfa93-66c0-4006-a44c-d6dc134f3b2d" source="pr_3819ccd2-dff9-4b60-8740-cbda7edf990e_p2" target="wnc1_s_wnc1_s396_wnc1_wnc1_csa47"> <start x="8690.25" y="1267.5"/> <end x="8847.0" y="1339.0"/> </arc> <arc class="inhibition" id="direct_529dde11-ed4e-4966-9a9d-c0d1cc16e1fd" source="wnc1_s_wnc1_s396_wnc1_wnc1_csa47" target="wnc1_s_wnc1_s412_wnc1_wnc1_sa320"> <start x="8897.0" y="1279.0"/> <end x="8849.0" y="591.0"/> </arc> <arc class="consumption" id="cons_c5bea724-6599-40dd-a6e1-b6ae5d5f6589" source="wnc1_s_wnc1_s366_wnc1_wnc1_csa45" target="pr_d1ec1bf8-9193-4b6c-801e-da4437e42a0f_p1"> <start x="7730.75" y="2486.0"/> <end x="7726.125" y="2494.75"/> </arc> <arc class="production" id="prod_d8130395-3dca-42db-9205-ee120cee1f0f" source="pr_d1ec1bf8-9193-4b6c-801e-da4437e42a0f_p2" target="wnc1_s_wnc1_s427_wnc1_wnc1_csa49"> <start x="7696.125" y="2494.75"/> <end x="7691.5" y="2503.5"/> </arc> <arc class="catalysis" id="modif_b4c0dc67-f7ed-46e4-9c3e-d490ad38f5ae" source="wnc1_s_wnc1_s366_wnc1_wnc1_csa45" target="pr_d1ec1bf8-9193-4b6c-801e-da4437e42a0f"> <start x="7920.25" y="2369.0"/> <next x="7920.229" y="2336.9639"/> <next x="7708.9883" y="2337.1028"/> <end x="7709.089" y="2490.1833"/> </arc> <arc class="consumption" id="cons_57a6f528-35b0-4578-a27a-f2ac8e557144" source="wnc1_s_wnc1_s427_wnc1_wnc1_csa49" target="pr_e376a36a-a7e3-43ea-9363-bd3c6d48827b_p1"> <start x="7499.5" y="2402.5"/> <end x="7498.25" y="2381.0"/> </arc> <arc class="production" id="prod_fd3f4cfe-84f6-4bac-997d-7b6657eeea12" source="pr_e376a36a-a7e3-43ea-9363-bd3c6d48827b_p2" target="wnc1_s_wnc1_s455_wnc1_wnc1_csa50"> <start x="7498.25" y="2351.0"/> <end x="7497.0" y="2329.5"/> </arc> <arc class="catalysis" id="modif_a992b2ce-14a4-4802-b915-2adf1fc31e7d" source="wnc1_s_wnc1_s469_wnc1_wnc1_sa349" target="pr_e376a36a-a7e3-43ea-9363-bd3c6d48827b"> <start x="7428.0" y="2376.0"/> <end x="7493.253" y="2366.1711"/> </arc> <arc class="consumption" id="cons_472c3b35-7a4e-4d7a-af21-742e54d723d6" source="wnc1_s_wnc1_s472_wnc1_wnc1_sa351" target="pr_f69e3856-e73a-4676-b8ae-f576e110c535_p1"> <start x="9043.25" y="1414.0"/> <end x="9044.25" y="1433.5"/> </arc> <arc class="production" id="prod_82f6a970-b155-4a9c-b441-f0b53fa1b06b" source="pr_f69e3856-e73a-4676-b8ae-f576e110c535_p2" target="wnc1_s_wnc1_s473_wnc1_wnc1_sa352"> <start x="9044.25" y="1463.5"/> <end x="9045.25" y="1483.0"/> </arc> <arc class="catalysis" id="modif_66d0173f-2131-4266-b043-4cf9748cc32d" source="wnc1_s_wnc1_s474_wnc1_wnc1_sa353" target="pr_f69e3856-e73a-4676-b8ae-f576e110c535"> <start x="9125.0" y="1449.0"/> <end x="9049.248" y="1448.3551"/> </arc> <arc class="consumption" id="cons_4a6cda52-bb1b-4f81-a8d8-da4b2cf83991" source="wnc1_s_wnc1_s600_wnc1_wnc1_csa53" target="pr_3445c5e2-3e66-46c2-bd49-5d116a04435e_p1"> <start x="8860.5" y="2047.5"/> <end x="8863.413" y="2035.0"/> </arc> <arc class="production" id="prod_fb390240-5aaf-4f90-91de-ebc8fd15ad0e" source="pr_3445c5e2-3e66-46c2-bd49-5d116a04435e_p2" target="wnc1_s_wnc1_s489_wnc1_wnc1_csa51"> <start x="8863.413" y="2005.0"/> <next x="8866.326" y="1992.5"/> <end x="8874.5" y="1913.5"/> </arc> <arc class="production" id="prod_c26f0cf4-991b-40df-9cf5-20ba358dd855" source="pr_3445c5e2-3e66-46c2-bd49-5d116a04435e_p2" target="wnc1_s_wnc1_s828_wnc1_wnc1_sa358"> <start x="8863.413" y="2005.0"/> <next x="8866.326" y="1992.5"/> <end x="8771.75" y="1986.5"/> </arc> <arc class="consumption" id="cons_e66c5551-5357-49f9-8594-dfd0a8eed7fb" source="wnc1_s_wnc1_s828_wnc1_wnc1_sa358" target="pr_df7b667c-a532-4336-991d-6ae0bc80393b_p1"> <start x="8691.75" y="1976.5"/> <end x="8667.875" y="1976.7096"/> </arc> <arc class="production" id="prod_abed359d-95ff-433d-998b-3c342b53f9c2" source="pr_df7b667c-a532-4336-991d-6ae0bc80393b_p2" target="wnc1_s_wnc1_s564_wnc1_wnc1_sa398"> <start x="8637.875" y="1976.7096"/> <end x="8614.0" y="1976.9192"/> </arc> <arc class="consumption" id="cons_4be5c516-8f8f-482e-bf14-856b17183ce8" source="wnc1_s_wnc1_s396_wnc1_wnc1_csa47" target="pr_03c530fa-db0f-4fe0-8f4e-f2e9d580f0bc_p1"> <start x="8947.0" y="1339.0"/> <next x="8965.0" y="1334.0"/> <end x="9168.0" y="1295.9004"/> </arc> <arc class="consumption" id="cons_1e2e0f18-bb27-43d3-b2f0-453cd99dcc9e" source="wnc1_s_wnc1_s473_wnc1_wnc1_sa352" target="pr_03c530fa-db0f-4fe0-8f4e-f2e9d580f0bc_p1"> <start x="9005.25" y="1503.0"/> <next x="8965.0" y="1334.0"/> <end x="9168.0" y="1295.9004"/> </arc> <arc class="production" id="prod_9b10a841-09b4-487d-ad8a-c1b0a125ceb6" source="pr_03c530fa-db0f-4fe0-8f4e-f2e9d580f0bc_p2" target="wnc1_s_wnc1_s398_wnc1_wnc1_csa48"> <start x="9198.0" y="1295.9004"/> <end x="9397.0" y="1258.5"/> </arc> <arc class="consumption" id="addreact_5cb5f47f-3507-427f-9b30-2e5911239e90" source="wnc1_s_wnc1_s718_wnc1_wnc1_sa461" target="pr_03c530fa-db0f-4fe0-8f4e-f2e9d580f0bc_p1"> <start x="9060.0" y="1251.0"/> <end x="9168.0" y="1295.9004"/> </arc> <arc class="consumption" id="cons_7d3e98ce-652c-498a-b4ab-1eddb1cb3164" source="wnc1_s_wnc1_s337_wnc1_wnc1_csa42" target="pr_a6c60ea8-25f3-4758-b6de-06134f3d30b9_p1"> <start x="9295.5" y="2169.5"/> <end x="9193.0" y="2158.75"/> </arc> <arc class="production" id="prod_2447c375-118a-4a4c-bed1-73309138d900" source="pr_a6c60ea8-25f3-4758-b6de-06134f3d30b9_p2" target="wnc1_s_wnc1_s600_wnc1_wnc1_csa53"> <start x="9163.0" y="2158.75"/> <end x="9060.5" y="2148.0"/> </arc> <arc class="consumption" id="cons_28ad8d17-9211-409b-b986-d4c0efc8922c" source="wnc1_s_wnc1_s585_wnc1_wnc1_sa412" target="pr_0248f657-bdd9-4ad8-bc07-e2f991fde4c8_p1"> <start x="9148.5" y="2296.5"/> <next x="9462.0" y="2307.0"/> <end x="9468.138" y="2311.25"/> </arc> <arc class="consumption" id="cons_900f3790-6fab-4da6-bc4b-d00438fecd3b" source="wnc1_s_wnc1_s337_wnc1_wnc1_csa42" target="pr_0248f657-bdd9-4ad8-bc07-e2f991fde4c8_p1"> <start x="9474.5" y="2271.0"/> <next x="9462.0" y="2307.0"/> <end x="9468.138" y="2311.25"/> </arc> <arc class="production" id="prod_84b9aead-b85a-465b-bf85-5b0e5d21232c" source="pr_0248f657-bdd9-4ad8-bc07-e2f991fde4c8_p2" target="wnc1_s_wnc1_s686_wnc1_wnc1_csa55"> <start x="9468.138" y="2341.25"/> <end x="9473.0" y="2341.5"/> </arc> <arc class="consumption" id="cons_2f768f20-63aa-4c4c-9b83-fb817cf05f8c" source="wnc1_s_wnc1_s686_wnc1_wnc1_csa55" target="pr_630c462a-bd88-4437-8388-1824f027c515_p1"> <start x="9473.0" y="2555.5"/> <end x="9439.25" y="2598.75"/> </arc> <arc class="production" id="prod_9f6dcd55-9714-4610-8a03-afb13adada8c" source="pr_630c462a-bd88-4437-8388-1824f027c515_p2" target="wnc1_s_wnc1_s701_wnc1_wnc1_csa56"> <start x="9439.25" y="2628.75"/> <end x="9405.5" y="2672.0"/> </arc> <arc class="consumption" id="cons_7f7b30ca-d8df-4f25-aa69-1e338449620a" source="wnc1_s_wnc1_s717_wnc1_wnc1_sa460" target="pr_1dea90e5-343b-43ad-9f49-cfb1f7e6d158_p1"> <start x="8597.624" y="2198.0"/> <end x="8598.266" y="2110.0"/> </arc> <arc class="production" id="prod_07d87113-4d1f-4ff3-a4c0-896445b91ffb" source="pr_1dea90e5-343b-43ad-9f49-cfb1f7e6d158_p2" target="wnc1_s_wnc1_s564_wnc1_wnc1_sa398"> <start x="8598.266" y="2080.0"/> <end x="8598.906" y="1992.0"/> </arc> <arc class="consumption" id="cons_6e08e8a7-c4d1-4926-abc2-71b6024ce8e2" source="wnc1_s_wnc1_s410_wnc1_wnc1_sa318" target="pr_010656ec-b365-4c73-8d5e-b6b9d6f3526b_p1"> <start x="8503.5" y="1196.0"/> <next x="8816.0" y="1121.0"/> <end x="8816.0" y="1113.0"/> </arc> <arc class="consumption" id="cons_4ebfbc38-ad6e-4ed7-a271-504c8462327d" source="wnc1_s_wnc1_s719_wnc1_wnc1_sa462" target="pr_010656ec-b365-4c73-8d5e-b6b9d6f3526b_p1"> <start x="8915.0" y="1121.0"/> <next x="8816.0" y="1121.0"/> <end x="8816.0" y="1113.0"/> </arc> <arc class="production" id="prod_c9532fa8-dea3-495e-8887-ec36cf39e7a7" source="pr_010656ec-b365-4c73-8d5e-b6b9d6f3526b_p2" target="wnc1_s_wnc1_s722_wnc1_wnc1_csa57"> <start x="8816.0" y="1083.0"/> <end x="8816.0" y="1079.0"/> </arc> <arc class="stimulation" id="direct_6ffce0da-03de-492d-a105-657cc5eb9a8f" source="wnc1_s_wnc1_s722_wnc1_wnc1_csa57" target="wnc1_s_wnc1_s412_wnc1_wnc1_sa320"> <start x="8816.0" y="959.0"/> <end x="8847.708" y="591.0"/> </arc> <arc class="consumption" id="cons_2e134850-e95b-485f-8d11-4e2ae5bdc5bb" source="wnc1_s_wnc1_s719_wnc1_wnc1_sa462" target="pr_cdd536ff-eaa7-421a-ae9c-9d513038286e_p1"> <start x="8875.0" y="1141.0"/> <end x="8847.25" y="1156.0"/> </arc> <arc class="production" id="prod_a2fa6125-17fe-4b14-9894-2fc624d14d18" source="pr_cdd536ff-eaa7-421a-ae9c-9d513038286e_p2" target="wnc1_s_wnc1_s724_wnc1_wnc1_sa465"> <start x="8847.25" y="1186.0"/> <end x="8819.5" y="1201.0"/> </arc> <arc class="catalysis" id="modif_4728d00b-69cc-4ba1-aba0-22e6d0c26f1c" source="wnc1_s1088_wnc1_wnc1_csa82" target="pr_cdd536ff-eaa7-421a-ae9c-9d513038286e"> <start x="8926.75" y="730.0"/> <end x="8843.579" y="1167.6047"/> </arc> <arc class="consumption" id="cons_8944cb09-4e6c-4cb4-84e9-5211931a478d" source="wnc1_s_wnc1_s725_wnc1_wnc1_sa466" target="pr_102a3b1f-a05f-4fb6-ae82-6ef2ebe41185_p1"> <start x="8652.0" y="1241.0"/> <next x="8723.0" y="1265.6875"/> <end x="8723.0" y="1281.8438"/> </arc> <arc class="consumption" id="cons_6f910cee-c5e6-4393-b49d-459d431e068f" source="wnc1_s_wnc1_s724_wnc1_wnc1_sa465" target="pr_102a3b1f-a05f-4fb6-ae82-6ef2ebe41185_p1"> <start x="8779.5" y="1241.0"/> <next x="8723.0" y="1265.6875"/> <end x="8723.0" y="1281.8438"/> </arc> <arc class="production" id="prod_a0bf73b6-89e5-4c55-bebf-eb914fb5ebd8" source="pr_102a3b1f-a05f-4fb6-ae82-6ef2ebe41185_p2" target="wnc1_s_wnc1_s726_wnc1_wnc1_csa58"> <start x="8723.0" y="1311.8438"/> <end x="8723.0" y="1324.0"/> </arc> <arc class="consumption" id="cons_23e3c4b7-9ae7-4a18-bff8-e544e0c496ff" source="wnc1_s_wnc1_s719_wnc1_wnc1_sa462" target="pr_557587fc-0186-4d9d-a7a8-bb2fd8ca66a6_p1"> <start x="8915.0" y="1141.0"/> <next x="8915.0" y="1613.0"/> <end x="8901.0" y="1613.0"/> </arc> <arc class="consumption" id="cons_ba3dcfd0-fd3b-49a9-a5de-799b0b4d39b3" source="wnc1_s_wnc1_s13_wnc1_wnc1_sa256" target="pr_557587fc-0186-4d9d-a7a8-bb2fd8ca66a6_p1"> <start x="9218.0" y="1844.0"/> <next x="8915.0" y="1613.0"/> <end x="8901.0" y="1613.0"/> </arc> <arc class="production" id="prod_e5fdcbc1-a7a1-49d3-bf7b-30ffe2e2a834" source="pr_557587fc-0186-4d9d-a7a8-bb2fd8ca66a6_p2" target="wnc1_s_wnc1_s729_wnc1_wnc1_csa59"> <start x="8871.0" y="1613.0"/> <end x="8861.0" y="1613.0"/> </arc> <arc class="consumption" id="cons_57c56c40-b05a-40e3-a878-41e568677bef" source="wnc1_s_wnc1_s729_wnc1_wnc1_csa59" target="pr_22466b7c-e26a-4cf8-871b-8f2e2ef8852a_p1"> <start x="8811.0" y="1553.0"/> <end x="8812.154" y="1543.0"/> </arc> <arc class="production" id="prod_c1c19d0f-659b-45f2-b592-f59c3170a644" source="pr_22466b7c-e26a-4cf8-871b-8f2e2ef8852a_p2" target="wnc1_s_wnc1_s732_wnc1_wnc1_sa471"> <start x="8812.154" y="1513.0"/> <end x="8813.308" y="1503.0"/> </arc> <arc class="consumption" id="cons_9cb89a10-6feb-4ab2-ba36-46b6e677075b" source="wnc1_s_wnc1_s792_wnc1_wnc1_sa514" target="pr_8e153155-d94a-4a00-ba9c-b4e229d526ca_p1"> <start x="9041.0" y="2418.0"/> <end x="8972.25" y="2373.5"/> </arc> <arc class="production" id="prod_14617893-dd64-46d4-9857-156833119fb8" source="pr_8e153155-d94a-4a00-ba9c-b4e229d526ca_p2" target="wnc1_s_wnc1_s1153_wnc1_wnc1_csa69"> <start x="8942.25" y="2373.5"/> <end x="8873.5" y="2329.0"/> </arc> <arc class="consumption" id="cons_bd0542e6-4ebd-4996-80c0-472782cfeb2c" source="wnc1_s_wnc1_s1172_wnc1_wnc1_sa534" target="pr_2bac3b25-8a15-445c-9192-290450a9e82f_p1"> <start x="7856.0" y="1900.0"/> <end x="7881.0" y="1900.0"/> </arc> <arc class="production" id="prod_11f090fb-7fe8-4193-b405-7219e612adcf" source="pr_2bac3b25-8a15-445c-9192-290450a9e82f_p2" target="wnc1_s_wnc1_s1165_wnc1_wnc1_sa535"> <start x="7911.0" y="1900.0"/> <end x="7936.0" y="1900.0"/> </arc> <arc class="consumption" id="cons_cb411242-c20a-48d0-8d8c-3843fadaf5cd" source="wnc1_s_wnc1_s1174_wnc1_wnc1_sa536" target="pr_1f0d36f6-19b8-4330-9504-080c888f0274_p1"> <start x="7987.5" y="1864.0"/> <end x="7988.0" y="1892.0"/> </arc> <arc class="production" id="prod_7cd28da6-71e1-4993-bf93-5849e0216fc0" source="pr_1f0d36f6-19b8-4330-9504-080c888f0274_p2" target="wnc1_s_wnc1_s1174_wnc1_wnc1_sa537"> <start x="7988.0" y="1922.0"/> <end x="7988.5" y="1950.0"/> </arc> <arc class="catalysis" id="modif_21451cdc-b878-47c3-b1b4-735e5446dfb0" source="wnc1_s_wnc1_s1165_wnc1_wnc1_sa535" target="pr_1f0d36f6-19b8-4330-9504-080c888f0274"> <start x="7976.0" y="1920.0"/> <end x="7983.0586" y="1912.0577"/> </arc> <arc class="consumption" id="cons_3312f808-0c18-461a-a489-74d5d489daee" source="wnc1_s_wnc1_s494_wnc1_wnc1_sa359" target="pr_9575931d-1120-45b2-8641-ff4745bdf036_p1"> <start x="8571.5" y="1878.5"/> <next x="8338.5" y="1887.0"/> <end x="8345.892" y="1864.25"/> </arc> <arc class="consumption" id="cons_07b5ecb1-524f-438f-bd60-f17ebacdb2e1" source="wnc1_s_wnc1_s896_wnc1_wnc1_csa68" target="pr_9575931d-1120-45b2-8641-ff4745bdf036_p1"> <start x="8333.25" y="1915.0"/> <next x="8338.5" y="1887.0"/> <end x="8345.892" y="1864.25"/> </arc> <arc class="production" id="prod_c13a3dfe-d0a5-4217-bdc2-35f32cd7c59e" source="pr_9575931d-1120-45b2-8641-ff4745bdf036_p2" target="wnc1_s_wnc1_s848_wnc1_wnc1_csa66"> <start x="8345.892" y="1834.25"/> <end x="8352.5" y="1815.5"/> </arc> <arc class="consumption" id="cons_781dd6ca-34c5-4be3-80b8-9cbefd68ff2c" source="wnc1_s_wnc1_s342_wnc1_wnc1_csa43" target="pr_d0be9214-c2e4-46c4-a75b-4ef6f66ca646_p1"> <start x="8132.0" y="2610.0"/> <next x="8130.108" y="2499.5762"/> <end x="8132.9287" y="2491.4543"/> </arc> <arc class="consumption" id="cons_7d5949b6-f8d8-41bf-9fd2-7f815cbcc389" source="wnc1_s_wnc1_s879_wnc1_wnc1_csa67" target="pr_d0be9214-c2e4-46c4-a75b-4ef6f66ca646_p1"> <start x="8145.75" y="2498.0"/> <next x="8130.108" y="2499.5762"/> <end x="8132.9287" y="2491.4543"/> </arc> <arc class="production" id="prod_232bec03-82be-4eae-8de2-0ef26dccee2b" source="pr_d0be9214-c2e4-46c4-a75b-4ef6f66ca646_p2" target="wnc1_s_wnc1_s366_wnc1_wnc1_csa45"> <start x="8102.9287" y="2491.4543"/> <end x="8109.75" y="2486.0"/> </arc> <arc class="consumption" id="cons_8b55e437-25a8-4331-9bf5-2da7ad422cfe" source="wnc1_s_wnc1_s701_wnc1_wnc1_csa56" target="pr_721a7755-f016-4138-9fcd-11e7291a9afa_p1"> <start x="9047.5" y="2672.0"/> <end x="9043.25" y="2671.6602"/> </arc> <arc class="production" id="prod_e79f2e65-f0e5-4bbe-90e3-d48c07c40443" source="pr_721a7755-f016-4138-9fcd-11e7291a9afa_p2" target="wnc1_s_wnc1_s355_wnc1_wnc1_csa44"> <start x="9013.25" y="2671.6602"/> <next x="9009.0" y="2671.3206"/> <end x="8972.5" y="2668.5"/> </arc> <arc class="production" id="prod_c5b5277a-38bb-468d-8f06-57f9646108c6" source="pr_721a7755-f016-4138-9fcd-11e7291a9afa_p2" target="wnc1_s_wnc1_s585_wnc1_wnc1_sa459"> <start x="9013.25" y="2671.6602"/> <next x="9009.0" y="2671.3206"/> <end x="9004.5" y="2529.0"/> </arc> <arc class="consumption" id="addreact_382ad858-0b27-441d-8bed-05a7981cfb8f" source="wnc1_s_wnc1_s894_wnc1_wnc1_sa592" target="pr_721a7755-f016-4138-9fcd-11e7291a9afa_p1"> <start x="9158.5" y="2528.0"/> <end x="9043.25" y="2671.6602"/> </arc> <arc class="production" id="addprod_b851b023-4938-445e-9cee-ca341821155d" source="pr_721a7755-f016-4138-9fcd-11e7291a9afa_p2" target="wnc1_s_wnc1_s717_wnc1_wnc1_sa460"> <start x="9013.25" y="2671.6602"/> <end x="8597.5" y="2238.0"/> </arc> <arc class="consumption" id="cons_067838d9-162d-4d9d-8ef6-b86154317590" source="wnc1_s_wnc1_s355_wnc1_wnc1_csa44" target="pr_a8188b79-cb75-48c9-b212-91b19672f0d4_p1"> <start x="8575.5" y="2561.5"/> <end x="8454.375" y="2354.25"/> </arc> <arc class="production" id="prod_0e4d9b90-d513-45ab-ab2f-ea16bec61b8e" source="pr_a8188b79-cb75-48c9-b212-91b19672f0d4_p2" target="wnc1_s_wnc1_s896_wnc1_wnc1_csa68"> <start x="8454.375" y="2324.25"/> <end x="8333.25" y="2117.0"/> </arc> <arc class="stimulation" id="modif_12de2791-008b-42ce-97a6-53117f0c073a" source="wnc1_s_wnc1_s1153_wnc1_wnc1_csa69" target="pr_a8188b79-cb75-48c9-b212-91b19672f0d4"> <start x="8772.5" y="2389.0"/> <end x="8458.766" y="2336.8572"/> </arc> <arc class="consumption" id="cons_dcb04670-7a4f-43e8-8417-b84d9f5d0b53" source="wnc1_s_wnc1_s894_wnc1_wnc1_sa592" target="pr_983063ad-581a-4018-b0af-dde727c33012_p1"> <start x="9133.5" y="2508.0"/> <end x="9111.5" y="2478.0"/> </arc> <arc class="production" id="prod_5bdfad4c-9ebd-40b3-9b05-b9cb299b4f29" source="pr_983063ad-581a-4018-b0af-dde727c33012_p2" target="wnc1_s_wnc1_s792_wnc1_wnc1_sa514"> <start x="9081.5" y="2478.0"/> <end x="9059.5" y="2448.0"/> </arc> <arc class="consumption" id="cons_f52f67d0-063a-458b-9c88-00f7968c0c18" source="wnc1_s_wnc1_s355_wnc1_wnc1_csa44" target="pr_58736388-29de-48bd-bb6c-47b876aaffbb_p1"> <start x="8575.5" y="2668.5"/> <end x="8542.125" y="2598.25"/> </arc> <arc class="production" id="prod_0c8388b2-5d36-41b5-98fa-885094f6959b" source="pr_58736388-29de-48bd-bb6c-47b876aaffbb_p2" target="wnc1_s_wnc1_s879_wnc1_wnc1_csa67"> <start x="8542.125" y="2568.25"/> <end x="8508.75" y="2498.0"/> </arc> <arc class="stimulation" id="modif_a5371b20-e47f-41ef-b5b8-c72c93849947" source="wnc1_s_wnc1_s1153_wnc1_wnc1_csa69" target="pr_58736388-29de-48bd-bb6c-47b876aaffbb"> <start x="8772.5" y="2389.0"/> <end x="8546.781" y="2581.4272"/> </arc> <arc class="consumption" id="cons_522f873f-7063-43f5-8b8e-2389efa5f92d" source="wnc1_s_wnc1_s1170_wnc1_wnc1_sa622" target="pr_85dbb3ea-a52a-44c5-8b23-cb71219879ae_p1"> <start x="7795.5" y="2110.5"/> <end x="7805.75" y="2030.25"/> </arc> <arc class="production" id="prod_2f6c4993-402d-4f31-9f60-0e2af5b8799e" source="pr_85dbb3ea-a52a-44c5-8b23-cb71219879ae_p2" target="wnc1_s_wnc1_s1172_wnc1_wnc1_sa534"> <start x="7805.75" y="2000.25"/> <end x="7816.0" y="1920.0"/> </arc> <arc class="catalysis" id="modif_c69dde6d-df0c-4de3-b417-888f35aa49a9" source="wnc1_s_wnc1_s848_wnc1_wnc1_csa66" target="pr_85dbb3ea-a52a-44c5-8b23-cb71219879ae"> <start x="8173.5" y="1815.5"/> <end x="7810.721" y="2015.7849"/> </arc> <arc class="stimulation" id="direct_c824b288-4004-423f-9699-379cc9d2772e" source="wnc1_s_wnc1_s945_wnc1_wnc1_csa74" target="wnc1_s_wnc1_s929_wnc1_wnc1_sa628"> <start x="8094.0" y="1405.0"/> <end x="8167.0" y="1405.0"/> </arc> <arc class="consumption" id="cons_42cc05ae-0a02-4e49-8790-da56e166957e" source="wnc1_s_wnc1_s848_wnc1_wnc1_csa66" target="pr_99a83938-fd48-4430-b3d4-153f6fb8235d_p1"> <start x="8173.5" y="1714.0"/> <end x="8176.5" y="1714.2144"/> </arc> <arc class="production" id="prod_1f7aea4b-bcfd-4082-980f-9670c20b3bd5" source="pr_99a83938-fd48-4430-b3d4-153f6fb8235d_p2" target="wnc1_s_wnc1_s494_wnc1_wnc1_sa629"> <start x="8146.5" y="1714.2144"/> <next x="8149.5" y="1714.4286"/> <end x="7995.5" y="1553.0"/> </arc> <arc class="production" id="prod_fb880758-3fe8-4f7d-8ed5-122dfa6585b0" source="pr_99a83938-fd48-4430-b3d4-153f6fb8235d_p2" target="wnc1_s_wnc1_s930_wnc1_wnc1_csa73"> <start x="8146.5" y="1714.2144"/> <next x="8149.5" y="1714.4286"/> <end x="8129.5" y="1718.0"/> </arc> <arc class="consumption" id="cons_e029655a-9dd2-47eb-a3d7-6c6e04af0eea" source="wnc1_s_wnc1_s494_wnc1_wnc1_sa629" target="pr_05bf8b64-4356-48e6-8509-da73ebf66a5e_p1"> <start x="7995.5" y="1513.0"/> <next x="8044.0" y="1492.75"/> <end x="8044.0" y="1491.875"/> </arc> <arc class="consumption" id="cons_e23acaf3-4de8-409b-9207-7e48a204bb5e" source="wnc1_s_wnc1_s944_wnc1_wnc1_sa645" target="pr_05bf8b64-4356-48e6-8509-da73ebf66a5e_p1"> <start x="8100.0" y="1512.0"/> <next x="8044.0" y="1492.75"/> <end x="8044.0" y="1491.875"/> </arc> <arc class="production" id="prod_31d1b60f-25e7-48b9-a4fd-c125c036e21d" source="pr_05bf8b64-4356-48e6-8509-da73ebf66a5e_p2" target="wnc1_s_wnc1_s945_wnc1_wnc1_csa74"> <start x="8044.0" y="1461.875"/> <end x="8044.0" y="1465.0"/> </arc> <arc class="consumption" id="cons_43cdc7e6-8c71-4566-aa52-9f7a25c211f2" source="wnc1_s_wnc1_s944_wnc1_wnc1_sa645" target="pr_003fef40-38df-4fd0-bc1a-801a10732ed7_p1"> <start x="8140.0" y="1532.0"/> <end x="8166.25" y="1532.5"/> </arc> <arc class="production" id="prod_63f94646-c820-41c4-922d-045c4b3b5f4b" source="pr_003fef40-38df-4fd0-bc1a-801a10732ed7_p2" target="wnc1_s_wnc1_s948_wnc1_wnc1_sa648"> <start x="8196.25" y="1532.5"/> <end x="8222.5" y="1533.0"/> </arc> <arc class="catalysis" id="modif_a48f8172-c42d-49c8-bc8f-10ca54ef1ba8" source="wnc1_s_wnc1_s117_wnc1_wnc1_sa101" target="pr_003fef40-38df-4fd0-bc1a-801a10732ed7"> <start x="7918.0" y="820.0"/> <end x="8181.3105" y="1527.5004"/> </arc> <arc class="consumption" id="cons_1cce8bd9-9e68-43f1-b9a0-323a1bf6a02e" source="wnc1_s_wnc1_s929_wnc1_wnc1_sa628" target="pr_8ccdda1b-ea41-4b8b-a463-3c7444289779_p1"> <start x="8203.599" y="1390.0"/> <end x="8163.7993" y="1229.5"/> </arc> <arc class="production" id="prod_d42fb002-fbd1-4523-94cd-0ee3750a082c" source="pr_8ccdda1b-ea41-4b8b-a463-3c7444289779_p2" target="wnc1_s_wnc1_s949_wnc1_wnc1_sa649"> <start x="8163.7993" y="1199.5"/> <end x="8124.0" y="1039.0"/> </arc> <arc class="consumption" id="cons_48d3bd4b-d3f5-4f13-83c3-c1a7a98f72ba" source="wnc1_s_wnc1_s929_wnc1_wnc1_sa628" target="pr_fa97a298-712a-4414-b6f5-7702252acb7c_p1"> <start x="8205.743" y="1390.0"/> <end x="8191.0405" y="1229.5"/> </arc> <arc class="production" id="prod_8619d6ac-52c6-49a3-bd64-a3c46b0a3a1e" source="pr_fa97a298-712a-4414-b6f5-7702252acb7c_p2" target="wnc1_s_wnc1_s951_wnc1_wnc1_sa651"> <start x="8191.0405" y="1199.5"/> <end x="8176.338" y="1039.0"/> </arc> <arc class="consumption" id="cons_bee73685-c079-44c5-9bbf-4b7db327101b" source="wnc1_s_wnc1_s929_wnc1_wnc1_sa628" target="pr_cf874fed-0b52-4478-aa0b-2424c9ff63f6_p1"> <start x="8207.798" y="1390.0"/> <end x="8217.133" y="1229.5"/> </arc> <arc class="production" id="prod_b0c0ac75-d8fe-4ebe-a2b7-21ad7f0f14ba" source="pr_cf874fed-0b52-4478-aa0b-2424c9ff63f6_p2" target="wnc1_s_wnc1_s950_wnc1_wnc1_sa650"> <start x="8217.133" y="1199.5"/> <end x="8226.468" y="1039.0"/> </arc> <arc class="consumption" id="cons_73811453-20f2-471c-b52d-82688b46d4f7" source="wnc1_s_wnc1_s949_wnc1_wnc1_sa649" target="pr_dcd36732-2702-40f7-a8bc-d9bb922060c2_p1"> <start x="8142.4653" y="1019.0"/> <end x="8192.634" y="983.70746"/> </arc> <arc class="production" id="prod_decd05d0-fc5e-4476-adc3-19fb8cbf9cd4" source="pr_dcd36732-2702-40f7-a8bc-d9bb922060c2_p2" target="wnc1_s_wnc1_s9_wnc1_wnc1_sa8"> <start x="8222.634" y="983.70746"/> <end x="8272.802" y="948.4149"/> </arc> <arc class="consumption" id="cons_77b4fb93-f444-469f-8c2a-d3c0b7f63d56" source="wnc1_s_wnc1_s951_wnc1_wnc1_sa651" target="pr_97532967-2155-415d-a08e-0d5fde74010b_p1"> <start x="8188.577" y="1019.0"/> <end x="8219.73" y="983.70746"/> </arc> <arc class="production" id="prod_31f1ef3e-ee19-441c-8f77-71d70b3994e4" source="pr_97532967-2155-415d-a08e-0d5fde74010b_p2" target="wnc1_s_wnc1_s9_wnc1_wnc1_sa8"> <start x="8249.73" y="983.70746"/> <end x="8280.884" y="948.4149"/> </arc> <arc class="consumption" id="cons_af153698-480f-4866-8280-67f3585cc561" source="wnc1_s_wnc1_s950_wnc1_wnc1_sa650" target="pr_32619d5e-2283-4ef5-aa73-4b20ccb76059_p1"> <start x="8234.689" y="1019.0"/> <end x="8261.828" y="998.70746"/> </arc> <arc class="production" id="prod_b2d18ad3-e65d-40e0-94fa-15e97131f719" source="pr_32619d5e-2283-4ef5-aa73-4b20ccb76059_p2" target="wnc1_s_wnc1_s9_wnc1_wnc1_sa8"> <start x="8261.828" y="968.70746"/> <end x="8288.966" y="948.4149"/> </arc> <arc class="consumption" id="cons_3e572271-8cac-4587-8eff-c489b2878a17" source="wnc1_s_wnc1_s949_wnc1_wnc1_sa649" target="pr_d57a12e3-f4db-476a-88cf-05d46ab165d8_p1"> <start x="8144.0" y="1022.0921"/> <end x="8251.0" y="979.954"/> </arc> <arc class="production" id="prod_ab9791c7-b19a-4330-b514-eca3125188e7" source="pr_d57a12e3-f4db-476a-88cf-05d46ab165d8_p2" target="wnc1_s_wnc1_s954_wnc1_wnc1_sa654"> <start x="8281.0" y="979.954"/> <end x="8388.0" y="937.8158"/> </arc> <arc class="consumption" id="cons_ce0ea0b6-5716-440d-8564-dc17c8d8cc08" source="wnc1_s_wnc1_s949_wnc1_wnc1_sa649" target="pr_3b54bf2b-a71d-473d-9317-f173da4571f8_p1"> <start x="8144.0" y="1024.7236"/> <end x="8251.0" y="998.6381"/> </arc> <arc class="production" id="prod_6c2640f8-0000-4578-9eed-8353f816d932" source="pr_3b54bf2b-a71d-473d-9317-f173da4571f8_p2" target="wnc1_s_wnc1_s952_wnc1_wnc1_sa652"> <start x="8281.0" y="998.6381"/> <end x="8388.0" y="972.5526"/> </arc> <arc class="consumption" id="cons_6bb6b519-c849-4220-98f7-fdffee799fce" source="wnc1_s_wnc1_s949_wnc1_wnc1_sa649" target="pr_b4579f80-1bab-4673-ab29-9e0cab405270_p1"> <start x="8144.0" y="1027.9438"/> <end x="8250.5" y="1021.528"/> </arc> <arc class="production" id="prod_2424c33a-b32f-4f42-bf24-e9d6525d8b8c" source="pr_b4579f80-1bab-4673-ab29-9e0cab405270_p2" target="wnc1_s_wnc1_s953_wnc1_wnc1_sa653"> <start x="8280.5" y="1021.528"/> <end x="8387.0" y="1015.1122"/> </arc> <arc class="consumption" id="cons_f0242329-6c81-41a3-9ed4-e63310720cef" source="wnc1_s_wnc1_s950_wnc1_wnc1_sa650" target="pr_a9ddf0f7-d574-4153-9b03-fe093eab4881_p1"> <start x="8246.143" y="1019.0"/> <end x="8307.715" y="979.0"/> </arc> <arc class="production" id="prod_1846d723-3799-4ad9-b485-20566813cb6b" source="pr_a9ddf0f7-d574-4153-9b03-fe093eab4881_p2" target="wnc1_s_wnc1_s954_wnc1_wnc1_sa654"> <start x="8337.715" y="979.0"/> <end x="8399.286" y="939.0"/> </arc> <arc class="consumption" id="cons_8113aa6c-da15-4c58-95f1-3549332421a7" source="wnc1_s_wnc1_s950_wnc1_wnc1_sa650" target="pr_b7316c25-1757-4f0f-b82d-3e9df901f3d7_p1"> <start x="8240.605" y="1019.0"/> <end x="8308.599" y="958.0"/> </arc> <arc class="production" id="prod_73e650b3-67d3-473a-8053-91026f65b2b1" source="pr_b7316c25-1757-4f0f-b82d-3e9df901f3d7_p2" target="wnc1_s_wnc1_s955_wnc1_wnc1_sa655"> <start x="8338.599" y="958.0"/> <end x="8406.592" y="897.0"/> </arc> <arc class="consumption" id="cons_e6d81914-af47-4f84-8a41-271ee1623057" source="wnc1_s_wnc1_s949_wnc1_wnc1_sa649" target="pr_d3818d7c-6c4a-40fc-bac8-fb57008594f5_p1"> <start x="8144.0" y="1019.29706"/> <end x="8255.041" y="958.14856"/> </arc> <arc class="production" id="prod_1583b7be-a5f1-4f3f-9da4-8517a1dcedc3" source="pr_d3818d7c-6c4a-40fc-bac8-fb57008594f5_p2" target="wnc1_s_wnc1_s955_wnc1_wnc1_sa655"> <start x="8285.041" y="958.14856"/> <end x="8396.082" y="897.0"/> </arc> <arc class="consumption" id="cons_90cdd34b-f985-4194-b432-c230aa35cace" source="wnc1_s_wnc1_s950_wnc1_wnc1_sa650" target="pr_60a58242-f8a9-40f5-9c00-b43be33e3ed5_p1"> <start x="8247.0" y="1027.4"/> <end x="8302.0" y="1021.80005"/> </arc> <arc class="production" id="prod_0b4551d4-ba6f-4cfa-bd88-9561306412f6" source="pr_60a58242-f8a9-40f5-9c00-b43be33e3ed5_p2" target="wnc1_s_wnc1_s953_wnc1_wnc1_sa653"> <start x="8332.0" y="1021.80005"/> <end x="8387.0" y="1016.2"/> </arc> <arc class="consumption" id="cons_23f934e0-6fc9-4aab-b395-a0cc2b18a5ee" source="wnc1_s_wnc1_s1172_wnc1_wnc1_sa656" target="pr_44a2dde0-7f2b-4e5c-b2d7-6e9fadc8f704_p1"> <start x="8177.75" y="2271.5"/> <end x="8202.75" y="2271.5"/> </arc> <arc class="production" id="prod_7ff2ce1b-8691-448b-bc54-700fd4bc9241" source="pr_44a2dde0-7f2b-4e5c-b2d7-6e9fadc8f704_p2" target="wnc1_s_wnc1_s1172_wnc1_wnc1_sa657"> <start x="8232.75" y="2271.5"/> <end x="8257.75" y="2271.5"/> </arc> <arc class="consumption" id="cons_a29387d0-a7f3-4e29-a8a7-d1908ae9995f" source="wnc1_s_wnc1_s1173_wnc1_wnc1_sa658" target="pr_8c9e2c54-1649-470a-93df-a0e900096336_p1"> <start x="8309.25" y="2235.5"/> <end x="8309.25" y="2263.5"/> </arc> <arc class="production" id="prod_f455ea45-8abc-424f-8070-c0c10fcf7f1d" source="pr_8c9e2c54-1649-470a-93df-a0e900096336_p2" target="wnc1_s_wnc1_s1174_wnc1_wnc1_sa659"> <start x="8309.25" y="2293.5"/> <end x="8309.25" y="2321.5"/> </arc> <arc class="catalysis" id="modif_0ba44ac8-58a3-43da-bc43-f84efae5cc4a" source="wnc1_s_wnc1_s1172_wnc1_wnc1_sa657" target="pr_8c9e2c54-1649-470a-93df-a0e900096336"> <start x="8297.75" y="2291.5"/> <end x="8304.25" y="2283.5"/> </arc> <arc class="consumption" id="cons_d71b0fd7-ae1a-4562-a0c8-41832ce68297" source="wnc1_s_wnc1_s455_wnc1_wnc1_csa50" target="pr_1e764b71-7bab-4b14-97ef-dcf86e17415b_p1"> <start x="7497.0" y="2133.5"/> <next x="7503.5" y="2073.0"/> <end x="7502.838" y="2052.0"/> </arc> <arc class="consumption" id="cons_db641aa6-6c50-4227-9182-915c1d732403" source="wnc1_s_wnc1_s976_wnc1_wnc1_sa680" target="pr_1e764b71-7bab-4b14-97ef-dcf86e17415b_p1"> <start x="7571.0" y="2071.0"/> <next x="7503.5" y="2073.0"/> <end x="7502.838" y="2052.0"/> </arc> <arc class="production" id="prod_9f0295df-a74c-42ba-9726-3653734f192b" source="pr_1e764b71-7bab-4b14-97ef-dcf86e17415b_p2" target="wnc1_s_wnc1_s960_wnc1_wnc1_csa76"> <start x="7502.838" y="2022.0"/> <end x="7502.25" y="2005.0"/> </arc> <arc class="consumption" id="addreact_fa8a9a15-b27a-402e-bfef-186a4ab0d4f4" source="wnc1_s_wnc1_s975_wnc1_wnc1_sa679" target="pr_1e764b71-7bab-4b14-97ef-dcf86e17415b_p1"> <start x="7426.0" y="2048.0"/> <end x="7502.838" y="2052.0"/> </arc> <arc class="consumption" id="addreact_35939ebd-2147-4d97-b1bf-5a5bc731c3fb" source="wnc1_s_wnc1_s979_wnc1_wnc1_sa683" target="pr_1e764b71-7bab-4b14-97ef-dcf86e17415b_p1"> <start x="7425.0" y="2095.0"/> <end x="7502.838" y="2052.0"/> </arc> <arc class="inhibition" id="direct_754b9c63-3f22-4d45-ba0a-f211d2f9894d" source="wnc1_s_wnc1_s1024_wnc1_wnc1_csa78" target="wnc1_s_wnc1_s955_wnc1_wnc1_sa655"> <start x="7835.0" y="1404.0"/> <end x="8427.0" y="897.0"/> </arc> <arc class="modulation" id="direct_c0d23b6b-e661-49bf-a9b9-bdcb14dab036" source="wnc1_s_wnc1_s1024_wnc1_wnc1_csa78" target="wnc1_s_wnc1_s981_wnc1_wnc1_sa685"> <start x="7835.0" y="1404.0"/> <end x="8500.316" y="897.0"/> </arc> <arc class="inhibition" id="direct_5bb9cc72-feec-4a77-b8c8-99a823694923" source="wnc1_s_wnc1_s1003_wnc1_wnc1_csa77" target="wnc1_s_wnc1_s982_wnc1_wnc1_sa686"> <start x="7681.875" y="1513.0"/> <end x="8497.681" y="939.0"/> </arc> <arc class="modulation" id="direct_cdd1b0fd-e95b-4f4f-8a32-16ee955af915" source="wnc1_s_wnc1_s1024_wnc1_wnc1_csa78" target="wnc1_s_wnc1_s983_wnc1_wnc1_sa687"> <start x="7835.0" y="1404.0"/> <end x="8497.923" y="991.0"/> </arc> <arc class="modulation" id="direct_5a86e959-6dbf-4d6a-9dda-ce79c69e5143" source="wnc1_s_wnc1_s1024_wnc1_wnc1_csa78" target="wnc1_s_wnc1_s984_wnc1_wnc1_sa688"> <start x="7835.0" y="1404.0"/> <end x="8498.117" y="1034.0"/> </arc> <arc class="consumption" id="cons_5a7421dc-e365-4d10-8ad2-3f8c2d278b38" source="wnc1_s_wnc1_s960_wnc1_wnc1_csa76" target="pr_525c63b0-c10c-4d9d-a3bd-43466c76003c_p1"> <start x="7502.25" y="1761.0"/> <end x="7501.899" y="1746.5"/> </arc> <arc class="production" id="prod_77758386-d632-4f6c-84db-7f81035fc6f8" source="pr_525c63b0-c10c-4d9d-a3bd-43466c76003c_p2" target="wnc1_s_wnc1_s1003_wnc1_wnc1_csa77"> <start x="7501.899" y="1716.5"/> <next x="7501.548" y="1702.0"/> <end x="7491.375" y="1635.0"/> </arc> <arc class="production" id="prod_c34d23f0-8053-44ac-b059-96bbeeb1f234" source="pr_525c63b0-c10c-4d9d-a3bd-43466c76003c_p2" target="wnc1_s_wnc1_s979_wnc1_wnc1_sa706"> <start x="7501.899" y="1716.5"/> <next x="7501.548" y="1702.0"/> <end x="7780.625" y="1574.0"/> </arc> <arc class="consumption" id="cons_051b83e4-4df9-4eec-a27f-98789d886b7b" source="wnc1_s_wnc1_s979_wnc1_wnc1_sa706" target="pr_9909c492-1076-4715-9790-87d66a38dd71_p1"> <start x="7780.625" y="1534.0"/> <next x="7784.625" y="1515.75"/> <end x="7784.827" y="1502.875"/> </arc> <arc class="consumption" id="cons_066b9c00-fe81-401c-a1cd-6bea1c5c5c73" source="wnc1_s_wnc1_s1020_wnc1_wnc1_sa707" target="pr_9909c492-1076-4715-9790-87d66a38dd71_p1"> <start x="7897.0" y="1534.0"/> <next x="7784.625" y="1515.75"/> <end x="7784.827" y="1502.875"/> </arc> <arc class="production" id="prod_4af31fd4-a0e9-4ad3-9fba-2ef074dd899a" source="pr_9909c492-1076-4715-9790-87d66a38dd71_p2" target="wnc1_s_wnc1_s1024_wnc1_wnc1_csa78"> <start x="7784.827" y="1472.875"/> <end x="7785.0" y="1464.0"/> </arc> <arc class="modulation" id="direct_ed8915b6-f4d3-482a-9e37-66a971dfe386" source="wnc1_s_wnc1_s1024_wnc1_wnc1_csa78" target="wnc1_s_wnc1_s1026_wnc1_wnc1_sa710"> <start x="7735.0" y="1344.0"/> <end x="7392.0" y="1289.3707"/> </arc> <arc class="modulation" id="direct_c76473d2-6c15-456b-903d-a53a10f3dcc5" source="wnc1_s_wnc1_s1024_wnc1_wnc1_csa78" target="wnc1_s_wnc1_s1027_wnc1_wnc1_sa711"> <start x="7735.0" y="1404.0"/> <end x="7395.0" y="1350.3158"/> </arc> <arc class="modulation" id="direct_bfbb32d4-0a14-4f92-b7cd-4b7820835b66" source="wnc1_s_wnc1_s1032_wnc1_wnc1_csa79" target="wnc1_s_wnc1_s118_wnc1_wnc1_sa102"> <start x="7691.0" y="1189.0"/> <end x="7907.042" y="918.0"/> </arc> <arc class="consumption" id="cons_d18032b0-d9ba-4ef1-9111-c40e315a5eba" source="wnc1_s_wnc1_s54_wnc1_wnc1_sa47" target="pr_9743da82-d41e-44dd-bc70-ee09860a53db_p1"> <start x="7482.0" y="430.0"/> <next x="7792.0" y="1246.7656"/> <end x="7782.0" y="1247.98"/> </arc> <arc class="consumption" id="cons_e2fb6a1a-96b9-435f-a44d-fc2153b58b71" source="wnc1_s_wnc1_s1028_wnc1_wnc1_sa712" target="pr_9743da82-d41e-44dd-bc70-ee09860a53db_p1"> <start x="7819.0" y="1248.0"/> <next x="7792.0" y="1246.7656"/> <end x="7782.0" y="1247.98"/> </arc> <arc class="production" id="prod_d8b71175-bbfb-4fde-84c1-143d97ee56e5" source="pr_9743da82-d41e-44dd-bc70-ee09860a53db_p2" target="wnc1_s_wnc1_s1032_wnc1_wnc1_csa79"> <start x="7752.0" y="1247.98"/> <end x="7746.0" y="1249.0"/> </arc> <arc class="catalysis" id="modif_4c5a3938-07bc-42c5-8744-c98651cf925d" source="wnc1_s_wnc1_s1024_wnc1_wnc1_csa78" target="pr_9743da82-d41e-44dd-bc70-ee09860a53db"> <start x="7785.0" y="1344.0"/> <end x="7767.2427" y="1252.9741"/> </arc> <arc class="inhibition" id="direct_d93d0af1-32f2-40ff-8c30-101f901c8168" source="wnc1_s_wnc1_s1032_wnc1_wnc1_csa79" target="wnc1_s_wnc1_s981_wnc1_wnc1_sa685"> <start x="7691.0" y="1189.0"/> <end x="8480.0" y="896.81305"/> </arc> <arc class="stimulation" id="direct_f7ed8a85-c6e7-4684-a01b-f94c9e8c3478" source="wnc1_s_wnc1_s945_wnc1_wnc1_csa74" target="wnc1_s_wnc1_s1035_wnc1_wnc1_sa718"> <start x="8094.0" y="1405.0"/> <end x="8170.0" y="1435.0"/> </arc> <arc class="consumption" id="cons_83442f8c-1d9b-423a-a180-581047010b06" source="wnc1_s_wnc1_s1035_wnc1_wnc1_sa718" target="pr_fb51c3e9-8223-4a32-a9f8-3a233f69eef9_p1"> <start x="8208.0" y="1435.0"/> <end x="8252.867" y="1206.7075"/> </arc> <arc class="production" id="prod_404694d1-6fb6-4914-9579-a8749cfb8213" source="pr_fb51c3e9-8223-4a32-a9f8-3a233f69eef9_p2" target="wnc1_s_wnc1_s9_wnc1_wnc1_sa8"> <start x="8252.867" y="1176.7075"/> <end x="8297.733" y="948.4149"/> </arc> <arc class="consumption" id="cons_92ed1e6a-2d74-4fd4-9f88-e08aca225d84" source="wnc1_s_wnc1_s1040_wnc1_wnc1_sa720" target="pr_bf09ce24-0555-4fa7-b301-50fbd711bd66_p1"> <start x="8667.0" y="877.0"/> <end x="8667.0" y="847.5"/> </arc> <arc class="production" id="prod_9ccac220-cd34-4519-bc88-390b1a53c2a4" source="pr_bf09ce24-0555-4fa7-b301-50fbd711bd66_p2" target="wnc1_s_wnc1_s1039_wnc1_wnc1_sa719"> <start x="8667.0" y="817.5"/> <end x="8667.0" y="788.0"/> </arc> <arc class="consumption" id="cons_6204e67d-254c-49c4-ad61-c22976d32b01" source="wnc1_s_wnc1_s1039_wnc1_wnc1_sa719" target="pr_94010c88-deef-47a4-868c-016c7b7bb7cd_p1"> <start x="8627.0" y="788.0"/> <end x="8627.0" y="817.5"/> </arc> <arc class="production" id="prod_756050b7-b8ec-4cef-86e4-07968f7964ba" source="pr_94010c88-deef-47a4-868c-016c7b7bb7cd_p2" target="wnc1_s_wnc1_s1040_wnc1_wnc1_sa720"> <start x="8627.0" y="847.5"/> <end x="8627.0" y="877.0"/> </arc> <arc class="catalysis" id="modif_fdf03e1b-b071-44b2-907c-d66bdb6af97e" source="wnc1_s_wnc1_s1041_wnc1_wnc1_sa727" target="pr_94010c88-deef-47a4-868c-016c7b7bb7cd"> <start x="8392.0" y="787.0"/> <end x="8622.0" y="832.5"/> </arc> <arc class="consumption" id="cons_542f55ac-021f-4541-97ad-4c756cbd63ce" source="wnc1_s_wnc1_s1041_wnc1_wnc1_sa722" target="pr_c338ee46-52fe-4643-9dcb-03acc296750c_p1"> <start x="8353.0" y="705.0"/> <end x="8352.5" y="721.0"/> </arc> <arc class="production" id="prod_ce2572fb-0757-48cc-a73b-0dd460e36608" source="pr_c338ee46-52fe-4643-9dcb-03acc296750c_p2" target="wnc1_s_wnc1_s1041_wnc1_wnc1_sa727"> <start x="8352.5" y="751.0"/> <end x="8352.0" y="767.0"/> </arc> <arc class="catalysis" id="modif_b84211de-3381-4dd4-aede-3dd67026e834" source="wnc1_s_wnc1_s119_wnc1_wnc1_sa104" target="pr_c338ee46-52fe-4643-9dcb-03acc296750c"> <start x="7601.5" y="852.0"/> <end x="8347.501" y="735.9194"/> </arc> <arc class="consumption" id="cons_62868d57-6bcd-4ac2-ad57-29188d73495a" source="wnc1_s_wnc1_s1045_wnc1_wnc1_sa723" target="pr_38b48307-2756-4de0-889d-231da019cf8c_p1"> <start x="7513.0" y="788.0"/> <next x="7589.0" y="771.0"/> <end x="7623.034" y="733.0"/> </arc> <arc class="consumption" id="cons_3ecf7086-8ae3-4a2c-b373-1e62574a581c" source="wnc1_s_wnc1_s119_wnc1_wnc1_sa104" target="pr_38b48307-2756-4de0-889d-231da019cf8c_p1"> <start x="7589.0" y="852.0"/> <next x="7589.0" y="771.0"/> <end x="7623.034" y="733.0"/> </arc> <arc class="production" id="prod_d9fd95e7-d1df-48db-a5b9-d5fc791913ca" source="pr_38b48307-2756-4de0-889d-231da019cf8c_p2" target="wnc1_s_wnc1_s1048_wnc1_wnc1_csa80"> <start x="7623.034" y="703.0"/> <end x="7654.5" y="669.0"/> </arc> <arc class="consumption" id="cons_413370ae-2bff-48d8-8eeb-93a685bbef8b" source="wnc1_s_wnc1_s1170_wnc1_wnc1_sa622" target="pr_eae1a0b9-01ae-45a0-8318-aafb9885b907_p1"> <start x="7795.5" y="2150.5"/> <end x="7951.625" y="2201.0"/> </arc> <arc class="production" id="prod_0660f384-8661-466a-9599-d0c227ffd7e2" source="pr_eae1a0b9-01ae-45a0-8318-aafb9885b907_p2" target="wnc1_s_wnc1_s1172_wnc1_wnc1_sa656"> <start x="7981.625" y="2201.0"/> <end x="8137.75" y="2251.5"/> </arc> <arc class="catalysis" id="modif_7ecc8d58-414f-48cc-962a-8f8c9300ce60" source="wnc1_s_wnc1_s848_wnc1_wnc1_csa66" target="pr_eae1a0b9-01ae-45a0-8318-aafb9885b907"> <start x="8263.0" y="1815.5"/> <end x="7968.04" y="2196.2043"/> </arc> <arc class="consumption" id="cons_7fa79c7a-50e9-42d4-ab13-71dfd5f15d03" source="wnc1_s_wnc2_s2_wnc1_wnc2_sa3" target="pr_978e4121-6123-4664-9dd5-ba60e414d056_p1"> <start x="9888.875" y="393.75"/> <next x="9937.0" y="438.0"/> <end x="9933.5" y="438.0"/> </arc> <arc class="consumption" id="cons_315597a7-4628-4001-8a30-be56bcce8013" source="wnc1_s_wnc2_s1_wnc1_wnc2_sa4" target="pr_978e4121-6123-4664-9dd5-ba60e414d056_p1"> <start x="9922.875" y="451.75"/> <next x="9937.0" y="438.0"/> <end x="9933.5" y="438.0"/> </arc> <arc class="production" id="prod_8139b078-775d-4145-968b-5ff171bb7299" source="pr_978e4121-6123-4664-9dd5-ba60e414d056_p2" target="wnc1_s_wnc2_s5_wnc1_wnc2_csa1"> <start x="9963.5" y="438.0"/> <end x="9956.0" y="438.0"/> </arc> <arc class="consumption" id="cons_e91d8262-1a78-4351-af99-2d43b956e7a9" source="wnc1_s_wnc2_s5_wnc1_wnc2_csa1" target="pr_6c78efb0-729b-4b78-9816-c5e8a24a2f10_p1"> <start x="10056.0" y="438.0"/> <end x="10091.4375" y="438.625"/> </arc> <arc class="production" id="prod_6660eb87-d6cb-4e3e-97a1-06f64b47842b" source="pr_6c78efb0-729b-4b78-9816-c5e8a24a2f10_p2" target="wnc1_s_wnc2_s13_wnc1_wnc2_csa2"> <start x="10121.4375" y="438.625"/> <end x="10156.875" y="439.25"/> </arc> <arc class="consumption" id="addreact_d89b8f01-9bad-4cc7-aaf4-98ef45275e81" source="wnc1_s_wnc2_s11_wnc1_wnc2_sa7" target="pr_6c78efb0-729b-4b78-9816-c5e8a24a2f10_p1"> <start x="10093.0" y="538.0"/> <end x="10091.4375" y="438.625"/> </arc> <arc class="consumption" id="cons_3c994634-b417-4bb0-a5a9-c3a3b3b81459" source="wnc1_s_wnc2_s17_wnc1_wnc2_sa10" target="pr_8e5f7182-3430-4b2e-8354-b6848ca3134c_p1"> <start x="11277.783" y="486.0"/> <end x="11277.783" y="513.5"/> </arc> <arc class="production" id="prod_0d5bb177-bbbc-4364-a08a-d6a345485c7e" source="pr_8e5f7182-3430-4b2e-8354-b6848ca3134c_p2" target="wnc1_s_wnc2_s18_wnc1_wnc2_sa11"> <start x="11277.783" y="543.5"/> <end x="11277.783" y="571.0"/> </arc> <arc class="catalysis" id="modif_74fe7494-8db4-46d3-b775-a89dfd493ed1" source="wnc1_s_wnc2_s19_wnc1_wnc2_sa12" target="pr_8e5f7182-3430-4b2e-8354-b6848ca3134c"> <start x="11346.0" y="528.0"/> <end x="11282.783" y="528.5"/> </arc> <arc class="inhibition" id="modif_c17d6f2f-f377-413a-974a-4e3357ff6bd7" source="wnc1_s_wnc2_s24_wnc1_wnc2_csa3" target="pr_8e5f7182-3430-4b2e-8354-b6848ca3134c"> <start x="11179.0" y="460.0"/> <end x="11272.783" y="528.5"/> </arc> <arc class="catalysis" id="modif_27d5c19d-77cd-493f-a174-579f58bbe405" source="wnc1_s_wnc2_s327_wnc1_wnc2_csa46" target="pr_8e5f7182-3430-4b2e-8354-b6848ca3134c"> <start x="11360.0" y="616.0"/> <end x="11282.783" y="533.5"/> </arc> <arc class="consumption" id="cons_65115eb7-1cdb-4d23-9b1b-2a6105008d59" source="wnc1_s_wnc2_s21_wnc1_wnc2_sa14" target="pr_0f56bf94-b37f-45f8-a154-a943c5dcea5a_p1"> <start x="10947.0" y="390.0"/> <next x="11020.25" y="460.0"/> <end x="11036.625" y="460.0"/> </arc> <arc class="consumption" id="cons_f334c912-6178-4845-9c26-fdc92abe7421" source="wnc1_s_wnc2_s20_wnc1_wnc2_sa13" target="pr_0f56bf94-b37f-45f8-a154-a943c5dcea5a_p1"> <start x="10952.0" y="459.0"/> <next x="11020.25" y="460.0"/> <end x="11036.625" y="460.0"/> </arc> <arc class="production" id="prod_0b2573e8-1c8c-4499-b086-0834abc2709e" source="pr_0f56bf94-b37f-45f8-a154-a943c5dcea5a_p2" target="wnc1_s_wnc2_s24_wnc1_wnc2_csa3"> <start x="11066.625" y="460.0"/> <end x="11079.0" y="460.0"/> </arc> <arc class="consumption" id="cons_fed4063a-17c4-4f5a-bcae-137c9d56a417" source="wnc1_s_wnc2_s18_wnc1_wnc2_sa11" target="pr_5daaaf06-0060-444d-af53-f6a5b958af06_p1"> <start x="11277.783" y="661.0"/> <end x="11277.783" y="679.0"/> </arc> <arc class="production" id="prod_8eb4b6b9-039a-471d-b437-f5803b041ecb" source="pr_5daaaf06-0060-444d-af53-f6a5b958af06_p2" target="wnc1_s_wnc2_s25_wnc1_wnc2_sa17"> <start x="11277.783" y="709.0"/> <end x="11277.783" y="727.0"/> </arc> <arc class="catalysis" id="modif_c1c20dfd-5dff-4fbf-a5e9-6767fdff722e" source="wnc1_s_wnc2_s327_wnc1_wnc2_csa46" target="pr_5daaaf06-0060-444d-af53-f6a5b958af06"> <start x="11360.0" y="616.0"/> <end x="11282.783" y="689.0"/> </arc> <arc class="consumption" id="cons_77fc221f-1c0c-4227-a4b0-0bab254b18f2" source="wnc1_s_wnc2_s333_wnc1_wnc2_csa4" target="pr_aabcc39b-d0bc-4832-906f-94aa7130af75_p1"> <start x="10378.0" y="615.0"/> <next x="10467.0" y="634.3125"/> <end x="10467.0" y="659.65625"/> </arc> <arc class="consumption" id="cons_98d4b588-3f16-4ecf-bd9c-34327bdd6181" source="wnc1_s_wnc2_s30_wnc1_wnc2_csa5" target="pr_aabcc39b-d0bc-4832-906f-94aa7130af75_p1"> <start x="10552.5" y="602.0"/> <next x="10467.0" y="634.3125"/> <end x="10467.0" y="659.65625"/> </arc> <arc class="production" id="prod_522030ed-1ecf-40f8-9a30-d4b4c8007c5f" source="pr_aabcc39b-d0bc-4832-906f-94aa7130af75_p2" target="wnc1_s_wnc2_s336_wnc1_wnc2_csa6"> <start x="10467.0" y="689.65625"/> <end x="10467.0" y="711.0"/> </arc> <arc class="consumption" id="cons_791096d5-ebef-4a25-8689-54795fd5c067" source="wnc1_s_wnc2_s333_wnc1_wnc2_csa4" target="pr_e6905997-bbf6-4ae2-a774-636b8d9a9d18_p1"> <start x="10378.0" y="615.0"/> <end x="10343.0" y="650.0"/> </arc> <arc class="production" id="prod_c863f066-93fa-41b2-9872-e6208244e8f6" source="pr_e6905997-bbf6-4ae2-a774-636b8d9a9d18_p2" target="wnc1_s_wnc2_s41_wnc1_wnc2_csa7"> <start x="10343.0" y="680.0"/> <end x="10308.0" y="715.0"/> </arc> <arc class="catalysis" id="modif_2e7ab187-e400-4030-a009-a3ed19cc44b7" source="wnc1_s_wnc2_s42_wnc1_wnc2_sa32" target="pr_e6905997-bbf6-4ae2-a774-636b8d9a9d18"> <start x="10282.0" y="648.0"/> <end x="10338.904" y="662.1327"/> </arc> <arc class="consumption" id="cons_b9dbe76b-f393-4e02-a358-796625863014" source="wnc1_s_wnc2_s333_wnc1_wnc2_csa4" target="pr_406dd083-e08a-4114-a789-caee926f1482_p1"> <start x="10328.0" y="555.0"/> <next x="10071.0" y="617.5"/> <end x="10072.311" y="645.75"/> </arc> <arc class="consumption" id="cons_d8f86644-3f18-4874-9ee1-c5fca1578a66" source="wnc1_s_wnc2_s43_wnc1_wnc2_sa33" target="pr_406dd083-e08a-4114-a789-caee926f1482_p1"> <start x="9975.0" y="618.0"/> <next x="10071.0" y="617.5"/> <end x="10072.311" y="645.75"/> </arc> <arc class="production" id="prod_420c954b-1579-4db8-9b16-fec655c2968d" source="pr_406dd083-e08a-4114-a789-caee926f1482_p2" target="wnc1_s_wnc2_s335_wnc1_wnc2_csa8"> <start x="10072.311" y="675.75"/> <end x="10073.5" y="700.0"/> </arc> <arc class="consumption" id="cons_77d3e7b3-4d85-4ba0-a490-4d505e4d0f63" source="wnc1_s_wnc2_s43_wnc1_wnc2_sa33" target="pr_19ff749f-12dc-4b8a-8971-0658eb5e6832_p1"> <start x="9935.0" y="638.0"/> <end x="9935.0" y="658.5"/> </arc> <arc class="production" id="prod_925a077f-5a29-4a21-9820-fa2467c08ef7" source="pr_19ff749f-12dc-4b8a-8971-0658eb5e6832_p2" target="wnc1_s_wnc2_s49_wnc1_wnc2_sa37"> <start x="9935.0" y="688.5"/> <end x="9935.0" y="709.0"/> </arc> <arc class="catalysis" id="modif_c42832a5-4ca5-4906-840d-51dad0e967cf" source="wnc1_s_wnc2_s42_wnc1_wnc2_sa32" target="pr_19ff749f-12dc-4b8a-8971-0658eb5e6832"> <start x="10202.0" y="648.0"/> <end x="9940.0" y="673.5"/> </arc> <arc class="consumption" id="cons_2ab66a22-0aff-4031-925d-bdc9cfb3b011" source="wnc1_s_wnc2_s50_wnc1_wnc2_sa38" target="pr_dd4ac5bc-58a6-4502-8411-c4cdd38d070b_p1"> <start x="10097.0" y="957.0"/> <end x="10147.0" y="957.0"/> </arc> <arc class="production" id="prod_108e33e8-78be-4e97-b04b-5eb6e255fa2e" source="pr_dd4ac5bc-58a6-4502-8411-c4cdd38d070b_p2" target="wnc1_s_wnc2_s51_wnc1_wnc2_sa39"> <start x="10177.0" y="957.0"/> <end x="10227.0" y="957.0"/> </arc> <arc class="catalysis" id="modif_8c0583c4-ee06-4beb-8bb2-f27eeffca273" source="wnc1_s_wnc2_s42_wnc1_wnc2_sa32" target="pr_dd4ac5bc-58a6-4502-8411-c4cdd38d070b"> <start x="10242.0" y="668.0"/> <end x="10162.0" y="952.0"/> </arc> <arc class="consumption" id="cons_5c824d79-71e8-4b71-bf0e-1b673e358fff" source="wnc1_s_wnc2_s51_wnc1_wnc2_sa39" target="pr_9ae8f5db-a0b2-4a6d-a607-80774b75c061_p1"> <start x="10267.0" y="977.0"/> <next x="10269.667" y="1054.0"/> <end x="10270.36" y="1090.5"/> </arc> <arc class="consumption" id="cons_879825d2-82b2-4d78-9f92-dda905f8f91e" source="wnc1_s_wnc2_s52_wnc1_wnc2_sa40" target="pr_9ae8f5db-a0b2-4a6d-a607-80774b75c061_p1"> <start x="10193.0" y="1054.0"/> <next x="10269.667" y="1054.0"/> <end x="10270.36" y="1090.5"/> </arc> <arc class="production" id="prod_5cd30058-7661-4819-b977-18e94f518835" source="pr_9ae8f5db-a0b2-4a6d-a607-80774b75c061_p2" target="wnc1_s_wnc2_s54_wnc1_wnc2_csa9"> <start x="10270.36" y="1120.5"/> <end x="10271.0" y="1153.0"/> </arc> <arc class="consumption" id="cons_ec4edcd2-d068-4bac-bf51-28d53a492cbb" source="wnc1_s_wnc2_s54_wnc1_wnc2_csa9" target="pr_a6a61149-39e4-48fd-8fa8-362c9553a1bf_p1"> <start x="10271.0" y="1273.0"/> <end x="10216.0" y="1306.5"/> </arc> <arc class="production" id="prod_dd25f508-e7cf-4ec0-a85c-e7f9d0bd7fde" source="pr_a6a61149-39e4-48fd-8fa8-362c9553a1bf_p2" target="wnc1_s_wnc2_s53_wnc1_wnc2_sa42"> <start x="10186.0" y="1306.5"/> <end x="10131.0" y="1340.0"/> </arc> <arc class="consumption" id="cons_67229fe0-a4f3-47ca-8510-5a6821cf7fe7" source="wnc1_s_wnc2_s53_wnc1_wnc2_sa42" target="pr_ec6079d5-f280-4d87-a4b5-9cd6515c3fce_p1"> <start x="10091.0" y="1355.2667"/> <end x="10071.0" y="1355.5"/> </arc> <arc class="production" id="prod_bd25a783-2952-4613-979d-27e5d403ab7b" source="pr_ec6079d5-f280-4d87-a4b5-9cd6515c3fce_p2" target="wnc1_s_wnc2_s57_wnc1_wnc2_sa45"> <start x="10041.0" y="1355.5"/> <end x="10021.0" y="1355.7333"/> </arc> <arc class="consumption" id="cons_fdb84a0a-8a35-414a-88e0-ea0bd0f2aae9" source="wnc1_s_wnc2_s53_wnc1_wnc2_sa42" target="pr_0ac121f0-a34c-4c55-99f7-d31cc3236cb4_p1"> <start x="10098.857" y="1370.0"/> <end x="10071.0" y="1390.0"/> </arc> <arc class="production" id="prod_de79b71b-8c9d-4e01-afe7-b6d93731fcaa" source="pr_0ac121f0-a34c-4c55-99f7-d31cc3236cb4_p2" target="wnc1_s_wnc2_s58_wnc1_wnc2_sa46"> <start x="10041.0" y="1390.0"/> <end x="10013.143" y="1410.0"/> </arc> <arc class="consumption" id="cons_1b6a913a-ab52-4896-a0f7-1874e03b1726" source="wnc1_s_wnc2_s52_wnc1_wnc2_sa40" target="pr_fc391cd6-2b42-4b14-aa76-f0632ee9f254_p1"> <start x="10113.0" y="1054.0"/> <end x="10100.5" y="1054.0"/> </arc> <arc class="production" id="prod_6071f2d9-3bb9-4089-a42b-7e684cd458f6" source="pr_fc391cd6-2b42-4b14-aa76-f0632ee9f254_p2" target="wnc1_s_wnc2_s59_wnc1_wnc2_sa47"> <start x="10070.5" y="1054.0"/> <end x="10058.0" y="1054.0"/> </arc> <arc class="catalysis" id="modif_fc4a1fb8-4ee7-4c77-bf3e-3676e4ee85dd" source="wnc1_s_wnc2_s42_wnc1_wnc2_sa32" target="pr_fc391cd6-2b42-4b14-aa76-f0632ee9f254"> <start x="10242.0" y="668.0"/> <end x="10085.5" y="1049.0"/> </arc> <arc class="consumption" id="cons_5b1adcab-2baa-4080-9513-8f6ba9c55f7d" source="wnc1_s_wnc2_s52_wnc1_wnc2_sa40" target="pr_878c751a-98eb-4469-bd7c-31ad54527d46_p1"> <start x="10153.0" y="1074.0"/> <next x="10150.0" y="1111.0"/> <end x="10150.0" y="1118.0"/> </arc> <arc class="consumption" id="cons_6934f446-8c21-4f9e-a14c-605f81f89c9b" source="wnc1_s_wnc2_s60_wnc1_wnc2_sa48" target="pr_878c751a-98eb-4469-bd7c-31ad54527d46_p1"> <start x="10116.0" y="1111.0"/> <next x="10150.0" y="1111.0"/> <end x="10150.0" y="1118.0"/> </arc> <arc class="production" id="prod_6bc36dbe-be35-4f43-bf9e-fe10c481e82a" source="pr_878c751a-98eb-4469-bd7c-31ad54527d46_p2" target="wnc1_s_wnc2_s61_wnc1_wnc2_csa10"> <start x="10150.0" y="1148.0"/> <end x="10150.0" y="1151.0"/> </arc> <arc class="consumption" id="cons_ff011357-4795-4c8a-8bf4-07f73c97d777" source="wnc1_s_wnc2_s61_wnc1_wnc2_csa10" target="pr_6f88cc8f-72ff-49ce-b9da-cb912c2bb0fd_p1"> <start x="10100.0" y="1211.0"/> <end x="10077.5" y="1211.0"/> </arc> <arc class="production" id="prod_5051b3ad-60e6-490e-bcbf-f228adf33188" source="pr_6f88cc8f-72ff-49ce-b9da-cb912c2bb0fd_p2" target="wnc1_s_wnc2_s64_wnc1_wnc2_csa11"> <start x="10047.5" y="1211.0"/> <end x="10025.0" y="1211.0"/> </arc> <arc class="consumption" id="addreact_621b9d9a-f7c8-4005-b34e-8b448092d0d9" source="wnc1_s_wnc2_s59_wnc1_wnc2_sa47" target="pr_6f88cc8f-72ff-49ce-b9da-cb912c2bb0fd_p1"> <start x="10018.0" y="1074.0"/> <end x="10077.5" y="1211.0"/> </arc> <arc class="production" id="addprod_1a5eced2-65c3-493f-8d81-ebdc359f1b92" source="pr_6f88cc8f-72ff-49ce-b9da-cb912c2bb0fd_p2" target="wnc1_s_wnc2_s52_wnc1_wnc2_sa40"> <start x="10047.5" y="1211.0"/> <end x="10153.0" y="1074.0"/> </arc> <arc class="consumption" id="cons_c7cdc244-b950-42eb-9d4b-7667dd9b641c" source="wnc1_s_wnc2_s42_wnc1_wnc2_sa32" target="pr_98c90e95-9f70-4883-927c-4f974f6f75a3_p1"> <start x="10224.4" y="668.0"/> <end x="10206.801" y="673.0"/> </arc> <arc class="production" id="prod_b0d67589-aca6-43f0-9b17-96421eb11f3b" source="pr_98c90e95-9f70-4883-927c-4f974f6f75a3_p2" target="wnc1_s_wnc2_s67_wnc1_wnc2_sa53"> <start x="10206.801" y="703.0"/> <end x="10189.2" y="708.0"/> </arc> <arc class="consumption" id="cons_539c30bf-a991-42fb-aed3-746745e667de" source="wnc1_s_wnc2_s69_wnc1_wnc2_sa55" target="pr_d523b005-6a3a-4852-908f-bc77d902cfc9_p1"> <start x="10754.0" y="664.0"/> <end x="10735.25" y="664.0"/> </arc> <arc class="production" id="prod_e2b62536-9ed2-422f-8ad8-173312abc39e" source="pr_d523b005-6a3a-4852-908f-bc77d902cfc9_p2" target="wnc1_s_wnc2_s70_wnc1_wnc2_sa56"> <start x="10705.25" y="664.0"/> <end x="10686.5" y="664.0"/> </arc> <arc class="catalysis" id="modif_73ef55ed-d677-4851-a1b8-625c8c715972" source="wnc1_s_wnc2_s68_wnc1_wnc2_sa54" target="pr_d523b005-6a3a-4852-908f-bc77d902cfc9"> <start x="10720.0" y="568.0"/> <end x="10720.25" y="659.0"/> </arc> <arc class="consumption" id="cons_9a4ed6bf-19f9-4441-98e8-747230482778" source="wnc1_s_wnc2_s42_wnc1_wnc2_sa32" target="pr_23439b1a-766b-4f76-852f-bdf9c4c1387a_p1"> <start x="10282.0" y="648.0"/> <next x="10645.75" y="715.0"/> <end x="10644.795" y="724.0"/> </arc> <arc class="consumption" id="cons_fa303f7e-f56c-41e9-9ce5-2b76e3537073" source="wnc1_s_wnc2_s70_wnc1_wnc2_sa56" target="pr_23439b1a-766b-4f76-852f-bdf9c4c1387a_p1"> <start x="10646.5" y="684.0"/> <next x="10645.75" y="715.0"/> <end x="10644.795" y="724.0"/> </arc> <arc class="production" id="prod_61d3644f-0eb2-414c-8a81-68e529734d27" source="pr_23439b1a-766b-4f76-852f-bdf9c4c1387a_p2" target="wnc1_s_wnc2_s71_wnc1_wnc2_csa12"> <start x="10644.795" y="754.0"/> <end x="10644.0" y="759.0"/> </arc> <arc class="modulation" id="modif_f05e96ca-a635-4b40-8212-b138be1bcd5c" source="wnc1_s_wnc2_s74_wnc1_wnc2_sa59" target="pr_23439b1a-766b-4f76-852f-bdf9c4c1387a"> <start x="10707.5" y="700.8142"/> <end x="10649.791" y="739.19855"/> </arc> <arc class="consumption" id="cons_2248cc75-2724-4a12-8f88-2ab9ca7a0dc9" source="wnc1_s_wnc2_s86_wnc1_wnc2_csa15" target="pr_0488411d-6a10-48f9-a485-7212e6e487a6_p1"> <start x="10356.5" y="1618.0"/> <end x="10330.0" y="1618.0"/> </arc> <arc class="production" id="prod_25fa31b1-0535-412a-8c22-007316fc1f44" source="pr_0488411d-6a10-48f9-a485-7212e6e487a6_p2" target="wnc1_s_wnc2_s77_wnc1_wnc2_csa14"> <start x="10300.0" y="1618.0"/> <end x="10273.5" y="1618.0"/> </arc> <arc class="catalysis" id="modif_7e8c1374-cc8e-4033-8fe5-0ec0a0205f04" source="wnc1_s_wnc2_s41_wnc1_wnc2_csa7" target="pr_0488411d-6a10-48f9-a485-7212e6e487a6"> <start x="10308.0" y="835.0"/> <end x="10315.0" y="1613.0"/> </arc> <arc class="catalysis" id="modif_3a6896cd-3e80-49d3-be3f-2a1616e5d1f2" source="wnc1_s_wnc2_s336_wnc1_wnc2_csa6" target="pr_0488411d-6a10-48f9-a485-7212e6e487a6"> <start x="10467.0" y="927.0"/> <end x="10320.0" y="1613.0"/> </arc> <arc class="consumption" id="cons_8a2904d6-41c3-4feb-abe4-3db7ad75ef8d" source="wnc1_s_wnc2_s79_wnc1_wnc2_csa13" target="pr_ca026cc0-847e-4603-b6ed-9fd78306e84a_p1"> <start x="10404.0" y="1329.0"/> <end x="10402.455" y="1318.5"/> </arc> <arc class="production" id="prod_f60be2ab-ec68-4b68-8aaf-2efebdb9aece" source="pr_ca026cc0-847e-4603-b6ed-9fd78306e84a_p2" target="wnc1_s_wnc2_s85_wnc1_wnc2_sa66"> <start x="10402.455" y="1288.5"/> <end x="10400.909" y="1278.0"/> </arc> <arc class="consumption" id="cons_3d4344e4-db4f-4e1f-8605-37d35d52ad9d" source="wnc1_s_wnc2_s91_wnc1_wnc2_sa71" target="pr_2cee8481-a9be-42a3-b30b-770742f36a6f_p1"> <start x="10062.75" y="1455.0"/> <end x="10091.756" y="1427.5"/> </arc> <arc class="production" id="prod_97ea5c74-2a18-4840-a93f-bd3699b65afb" source="pr_2cee8481-a9be-42a3-b30b-770742f36a6f_p2" target="wnc1_s_wnc2_s53_wnc1_wnc2_sa42"> <start x="10091.756" y="1397.5"/> <end x="10120.763" y="1370.0"/> </arc> <arc class="consumption" id="cons_6a6857f8-2b9a-4115-b4b9-7562f03bb000" source="wnc1_s_wnc2_s79_wnc1_wnc2_csa13" target="pr_8719ef05-f4c7-4091-975d-80fd5bc9014e_p1"> <start x="10404.0" y="1453.0"/> <end x="10404.25" y="1489.5"/> </arc> <arc class="production" id="prod_aa444d14-18d7-4d54-89f9-8f551ba8d188" source="pr_8719ef05-f4c7-4091-975d-80fd5bc9014e_p2" target="wnc1_s_wnc2_s86_wnc1_wnc2_csa15"> <start x="10404.25" y="1519.5"/> <end x="10404.5" y="1556.0"/> </arc> <arc class="consumption" id="cons_04bd0573-d3d1-4873-8ebc-9896546367de" source="wnc1_s_wnc2_s77_wnc1_wnc2_csa14" target="pr_bab6ac76-d214-4eba-84f7-0cd575df3f2f_p1"> <start x="10177.5" y="1618.0"/> <end x="10172.375" y="1618.0"/> </arc> <arc class="production" id="prod_d424aab8-4888-44a8-8dfd-c18e1e6af0ff" source="pr_bab6ac76-d214-4eba-84f7-0cd575df3f2f_p2" target="wnc1_s_wnc2_s90_wnc1_wnc2_sa70"> <start x="10142.375" y="1618.0"/> <next x="10137.25" y="1618.0"/> <end x="10102.75" y="1575.0"/> </arc> <arc class="production" id="prod_6b1fd2f6-4a0b-4c8a-8efc-0e9f365e4296" source="pr_bab6ac76-d214-4eba-84f7-0cd575df3f2f_p2" target="wnc1_s_wnc2_s89_wnc1_wnc2_sa69"> <start x="10142.375" y="1618.0"/> <next x="10137.25" y="1618.0"/> <end x="10102.75" y="1658.0"/> </arc> <arc class="consumption" id="cons_0ee72bad-59d1-482a-a253-dac0bac7d68c" source="wnc1_s_wnc2_s90_wnc1_wnc2_sa70" target="pr_45bce482-4902-4a13-90dd-2d9351862a47_p1"> <start x="10062.75" y="1555.0"/> <end x="10062.75" y="1540.0"/> </arc> <arc class="production" id="prod_0ac04de7-9c5e-415e-9dfe-41181786ae18" source="pr_45bce482-4902-4a13-90dd-2d9351862a47_p2" target="wnc1_s_wnc2_s91_wnc1_wnc2_sa71"> <start x="10062.75" y="1510.0"/> <end x="10062.75" y="1495.0"/> </arc> <arc class="consumption" id="cons_5a877746-8c60-441f-b044-e8e7d8b20af5" source="wnc1_s_wnc2_s92_wnc1_wnc2_sa72" target="pr_cb250aef-f35a-40b2-8186-1003ea413db7_p1"> <start x="10558.0" y="1391.0"/> <end x="10520.0" y="1391.0"/> </arc> <arc class="production" id="prod_0e8429b4-6e42-469d-9c71-9046b44620a3" source="pr_cb250aef-f35a-40b2-8186-1003ea413db7_p2" target="wnc1_s_wnc2_s79_wnc1_wnc2_csa13"> <start x="10490.0" y="1391.0"/> <end x="10452.0" y="1391.0"/> </arc> <arc class="consumption" id="cons_bc60f7f0-c56f-4f44-b70d-5a5ecf80fd07" source="wnc1_s_wnc2_s92_wnc1_wnc2_sa72" target="pr_c7039f4c-d559-426d-bfae-98dd166d10f7_p1"> <start x="10598.0" y="1376.0"/> <end x="10598.0" y="1322.5"/> </arc> <arc class="production" id="prod_1356d56d-6703-4a26-af72-b276e59739c2" source="pr_c7039f4c-d559-426d-bfae-98dd166d10f7_p2" target="wnc1_s_wnc2_s93_wnc1_wnc2_sa73"> <start x="10598.0" y="1292.5"/> <end x="10598.0" y="1239.0"/> </arc> <arc class="consumption" id="cons_9a2c99bb-588f-433f-8aaf-d60b26c040b1" source="wnc1_s_wnc2_s93_wnc1_wnc2_sa73" target="pr_7c2fc10d-ae0b-45ac-96b0-2d86059143dc_p1"> <start x="10598.0" y="1199.0"/> <end x="10598.0" y="1175.5"/> </arc> <arc class="production" id="prod_b4027eb4-f2c6-4b5c-84c4-6cd64bf59827" source="pr_7c2fc10d-ae0b-45ac-96b0-2d86059143dc_p2" target="wnc1_s_wnc2_s94_wnc1_wnc2_sa74"> <start x="10598.0" y="1145.5"/> <end x="10598.0" y="1122.0"/> </arc> <arc class="catalysis" id="modif_bc8fcf7c-c664-4536-a613-bf56be5a2ea3" source="wnc1_s_wnc2_s41_wnc1_wnc2_csa7" target="pr_7c2fc10d-ae0b-45ac-96b0-2d86059143dc"> <start x="10308.0" y="835.0"/> <end x="10593.0" y="1160.5"/> </arc> <arc class="consumption" id="cons_1a342569-74f5-4104-89d3-4912cfcbb2b7" source="wnc1_s_wnc2_s41_wnc1_wnc2_csa7" target="pr_edf74730-364b-4dcf-bc89-489af4d4ab52_p1"> <start x="10308.0" y="835.0"/> <next x="10662.0" y="1079.5"/> <end x="10693.25" y="1079.5"/> </arc> <arc class="consumption" id="cons_204e480c-9cba-4dbc-96b6-f2521f84fe22" source="wnc1_s_wnc2_s94_wnc1_wnc2_sa74" target="pr_edf74730-364b-4dcf-bc89-489af4d4ab52_p1"> <start x="10638.0" y="1102.0"/> <next x="10662.0" y="1079.5"/> <end x="10693.25" y="1079.5"/> </arc> <arc class="production" id="prod_d75174d1-46f4-46e2-b8ff-ec58533c9ca7" source="pr_edf74730-364b-4dcf-bc89-489af4d4ab52_p2" target="wnc1_s_wnc2_s95_wnc1_wnc2_csa16"> <start x="10723.25" y="1079.5"/> <end x="10750.5" y="1079.5"/> </arc> <arc class="consumption" id="cons_296cd5f8-39e7-4889-8e53-74f012fe56ad" source="wnc1_s_wnc2_s95_wnc1_wnc2_csa16" target="pr_65b2408e-aecc-4b37-beb3-935e4a10bf54_p1"> <start x="10802.0" y="1167.0"/> <end x="10802.625" y="1438.25"/> </arc> <arc class="production" id="prod_99f9180a-8fc1-488c-b761-fedd6400b34b" source="pr_65b2408e-aecc-4b37-beb3-935e4a10bf54_p2" target="wnc1_s_wnc2_s99_wnc1_wnc2_csa17"> <start x="10802.625" y="1468.25"/> <end x="10803.25" y="1739.5"/> </arc> <arc class="consumption" id="cons_f30159f6-6e82-44f4-916d-9d47a7b30bc0" source="wnc1_s_wnc2_s41_wnc1_wnc2_csa7" target="pr_8fb59f4e-39c2-43b7-9309-2fda64fa8e5c_p1"> <start x="10358.0" y="775.0"/> <next x="10824.5" y="726.0"/> <end x="10863.0" y="726.2597"/> </arc> <arc class="consumption" id="cons_2f832553-ea49-499a-b90e-0c2d3fa5afe7" source="wnc1_s_wnc2_s103_wnc1_wnc2_sa81" target="pr_8fb59f4e-39c2-43b7-9309-2fda64fa8e5c_p1"> <start x="10822.0" y="801.0"/> <next x="10824.5" y="726.0"/> <end x="10863.0" y="726.2597"/> </arc> <arc class="production" id="prod_b71f3601-3021-47d8-8a5f-476010f1c603" source="pr_8fb59f4e-39c2-43b7-9309-2fda64fa8e5c_p2" target="wnc1_s_wnc2_s105_wnc1_wnc2_csa18"> <start x="10893.0" y="726.2597"/> <end x="10927.5" y="726.5"/> </arc> <arc class="consumption" id="cons_c4626526-88dc-4f5d-973e-37ba3c03450e" source="wnc1_s_wnc2_s105_wnc1_wnc2_csa18" target="pr_5abac755-a3d5-430b-b291-a9f57f4002ae_p1"> <start x="11004.75" y="814.0"/> <end x="11004.75" y="855.0"/> </arc> <arc class="production" id="prod_fa047316-14ca-4cad-a7db-1a6c57d3a40b" source="pr_5abac755-a3d5-430b-b291-a9f57f4002ae_p2" target="wnc1_s_wnc2_s109_wnc1_wnc2_csa19"> <start x="11004.75" y="885.0"/> <end x="11004.75" y="926.0"/> </arc> <arc class="consumption" id="cons_f151ea37-36e8-46d8-b144-9caac63afe4f" source="wnc1_s_wnc2_s342_wnc1_wnc2_csa25" target="pr_9d8333d2-b3b1-4ed5-95a1-3854c64cfbc4_p1"> <start x="10928.75" y="1526.5"/> <end x="10950.875" y="1618.0"/> </arc> <arc class="production" id="prod_1aa2528f-00a6-485c-b903-120667946406" source="pr_9d8333d2-b3b1-4ed5-95a1-3854c64cfbc4_p2" target="wnc1_s_wnc2_s156_wnc1_wnc2_csa20"> <start x="10950.875" y="1648.0"/> <end x="10973.0" y="1739.5"/> </arc> <arc class="consumption" id="cons_1ae368ae-0e02-484d-a35a-b515d5e58df0" source="wnc1_s_wnc2_s336_wnc1_wnc2_csa6" target="pr_1abf1b85-6c15-42a2-aa07-b0fe1ecfc0dc_p1"> <start x="10518.0" y="819.0"/> <next x="10811.5" y="710.0"/> <end x="10942.25" y="709.7465"/> </arc> <arc class="consumption" id="cons_fedcd4a0-e692-4703-a60a-0a040061b3f7" source="wnc1_s_wnc2_s103_wnc1_wnc2_sa81" target="pr_1abf1b85-6c15-42a2-aa07-b0fe1ecfc0dc_p1"> <start x="10822.0" y="801.0"/> <next x="10811.5" y="710.0"/> <end x="10942.25" y="709.7465"/> </arc> <arc class="production" id="prod_e639f8c9-d4c5-46ca-9e4c-4ad6911cf6bf" source="pr_1abf1b85-6c15-42a2-aa07-b0fe1ecfc0dc_p2" target="wnc1_s_wnc2_s344_wnc1_wnc2_csa21"> <start x="10972.25" y="709.7465"/> <end x="11099.0" y="709.5"/> </arc> <arc class="consumption" id="cons_7f6411ac-db71-4ca5-ae72-d0e818fb28a0" source="wnc1_s_wnc2_s344_wnc1_wnc2_csa21" target="pr_865f4271-2a00-4437-a861-6782a11b3fbe_p1"> <start x="11152.5" y="848.0"/> <end x="11152.5" y="868.0"/> </arc> <arc class="production" id="prod_f269d14e-fe69-4e1b-b8ff-7dfbd55bd675" source="pr_865f4271-2a00-4437-a861-6782a11b3fbe_p2" target="wnc1_s_wnc2_s343_wnc1_wnc2_csa22"> <start x="11152.5" y="898.0"/> <end x="11152.5" y="918.0"/> </arc> <arc class="consumption" id="cons_3a50716f-4213-4945-9b59-7d486ab94e42" source="wnc1_s_wnc2_s341_wnc1_wnc2_csa24" target="pr_762dc50e-0cfe-4f04-bb52-681512ff6499_p1"> <start x="11151.5" y="1592.0"/> <end x="11151.875" y="1650.75"/> </arc> <arc class="production" id="prod_9bd5de93-1023-4c10-b663-ec3ed4570e56" source="pr_762dc50e-0cfe-4f04-bb52-681512ff6499_p2" target="wnc1_s_wnc2_s339_wnc1_wnc2_csa23"> <start x="11151.875" y="1680.75"/> <end x="11152.25" y="1739.5"/> </arc> <arc class="catalysis" id="modif_a2ea300b-ee6d-4e25-9d12-0d051c499eb3" source="wnc1_s_wnc2_s223_wnc1_wnc2_csa33" target="pr_762dc50e-0cfe-4f04-bb52-681512ff6499"> <start x="11571.0" y="1155.5"/> <end x="11156.875" y="1665.7246"/> </arc> <arc class="catalysis" id="modif_55e3ac8b-474e-4918-81c5-1c0f71bd95aa" source="wnc1_s_wnc2_s255_wnc1_wnc2_sa203" target="pr_762dc50e-0cfe-4f04-bb52-681512ff6499"> <start x="10609.0" y="1792.0"/> <end x="11146.875" y="1665.7754"/> </arc> <arc class="consumption" id="cons_ee0fbe16-30b2-4b54-802a-58ab2bee0d1d" source="wnc1_s_wnc2_s343_wnc1_wnc2_csa22" target="pr_1156657d-639b-4bb3-9906-66b8ffa995be_p1"> <start x="11152.5" y="1176.0"/> <next x="11152.0" y="1206.0"/> <end x="11151.742" y="1255.5"/> </arc> <arc class="consumption" id="cons_e01ab218-0c57-4de8-8b1b-5e2ffa38c1b8" source="wnc1_s_wnc2_s136_wnc1_wnc2_sa110" target="pr_1156657d-639b-4bb3-9906-66b8ffa995be_p1"> <start x="11115.5" y="1209.0"/> <next x="11152.0" y="1206.0"/> <end x="11151.742" y="1255.5"/> </arc> <arc class="production" id="prod_3672511e-307b-490d-8f90-c54599e0bf68" source="pr_1156657d-639b-4bb3-9906-66b8ffa995be_p2" target="wnc1_s_wnc2_s341_wnc1_wnc2_csa24"> <start x="11151.742" y="1285.5"/> <end x="11151.5" y="1331.0"/> </arc> <arc class="consumption" id="addreact_54cc4462-c248-43d9-b532-a76a5cde38be" source="wnc1_s_wnc2_s137_wnc1_wnc2_sa109" target="pr_1156657d-639b-4bb3-9906-66b8ffa995be_p1"> <start x="11115.5" y="1251.0"/> <end x="11151.742" y="1255.5"/> </arc> <arc class="consumption" id="addreact_29123f8e-1d5d-42a1-a71c-95f8767c8653" source="wnc1_s_wnc2_s171_wnc1_wnc2_sa144" target="pr_1156657d-639b-4bb3-9906-66b8ffa995be_p1"> <start x="11321.0" y="1082.5"/> <end x="11151.742" y="1255.5"/> </arc> <arc class="consumption" id="cons_03fc3ade-c339-432d-955e-eee6f8490ed6" source="wnc1_s_wnc2_s109_wnc1_wnc2_csa19" target="pr_8f17f8ed-19d0-4123-8c9c-d1433a9b9283_p1"> <start x="10979.0" y="1101.0"/> <next x="10978.5" y="1209.0"/> <end x="10952.8125" y="1257.25"/> </arc> <arc class="consumption" id="cons_4838a62c-f71e-4322-8027-02636803701b" source="wnc1_s_wnc2_s136_wnc1_wnc2_sa110" target="pr_8f17f8ed-19d0-4123-8c9c-d1433a9b9283_p1"> <start x="11035.5" y="1209.0"/> <next x="10978.5" y="1209.0"/> <end x="10952.8125" y="1257.25"/> </arc> <arc class="production" id="prod_868ab728-0b81-4b89-8865-037f2909eae5" source="pr_8f17f8ed-19d0-4123-8c9c-d1433a9b9283_p2" target="wnc1_s_wnc2_s342_wnc1_wnc2_csa25"> <start x="10952.8125" y="1287.25"/> <end x="10928.75" y="1331.5"/> </arc> <arc class="consumption" id="addreact_09d0502c-eb64-4cfc-8208-ea8d36e53db4" source="wnc1_s_wnc2_s137_wnc1_wnc2_sa109" target="pr_8f17f8ed-19d0-4123-8c9c-d1433a9b9283_p1"> <start x="11035.5" y="1251.0"/> <end x="10952.8125" y="1257.25"/> </arc> <arc class="consumption" id="addreact_67c874cb-0454-4dc7-8e20-acf6702d330e" source="wnc1_s_wnc2_s171_wnc1_wnc2_sa144" target="pr_8f17f8ed-19d0-4123-8c9c-d1433a9b9283_p1"> <start x="11321.0" y="1082.5"/> <end x="10952.8125" y="1257.25"/> </arc> <arc class="consumption" id="cons_cf829109-7858-4f80-afd6-b3251010f9c5" source="wnc1_s_wnc2_s163_wnc1_wnc2_csa27" target="pr_f4dc6ed9-35c1-4f47-8b11-e4fabb2b73cf_p1"> <start x="11617.0" y="673.0"/> <end x="11538.125" y="694.7859"/> </arc> <arc class="production" id="prod_a7d9c4eb-e91e-4219-8dc4-ba183b888a3f" source="pr_f4dc6ed9-35c1-4f47-8b11-e4fabb2b73cf_p2" target="wnc1_s_wnc2_s103_wnc1_wnc2_sa81"> <start x="11508.125" y="694.7859"/> <next x="11429.25" y="716.5717"/> <end x="10862.0" y="801.0"/> </arc> <arc class="production" id="prod_e1ab615d-5dad-4a09-b87e-2eaa26ccffdc" source="pr_f4dc6ed9-35c1-4f47-8b11-e4fabb2b73cf_p2" target="wnc1_s_wnc2_s167_wnc1_wnc2_sa140"> <start x="11508.125" y="694.7859"/> <next x="11429.25" y="716.5717"/> <end x="11424.5" y="766.5"/> </arc> <arc class="catalysis" id="modif_08805aa2-28f2-4581-8609-0cee66be0e98" source="wnc1_s_wnc2_s74_wnc1_wnc2_sa59" target="pr_f4dc6ed9-35c1-4f47-8b11-e4fabb2b73cf"> <start x="10732.5" y="692.4772"/> <end x="11517.124" y="691.04565"/> </arc> <arc class="production" id="addprod_4ae58372-08c2-4e12-ad85-93a47ab84aab" source="pr_f4dc6ed9-35c1-4f47-8b11-e4fabb2b73cf_p2" target="wnc1_s_wnc2_s166_wnc1_wnc2_sa139"> <start x="11508.125" y="694.7859"/> <end x="11523.625" y="766.5"/> </arc> <arc class="production" id="addprod_82acee31-3202-4c43-80bb-472f1b511c68" source="pr_f4dc6ed9-35c1-4f47-8b11-e4fabb2b73cf_p2" target="wnc1_s_wnc2_s169_wnc1_wnc2_sa142"> <start x="11508.125" y="694.7859"/> <end x="11622.75" y="766.5"/> </arc> <arc class="production" id="addprod_3889b3ee-4281-4f5a-a9f4-a01929d7316c" source="pr_f4dc6ed9-35c1-4f47-8b11-e4fabb2b73cf_p2" target="wnc1_s_wnc2_s134_wnc1_wnc2_sa127"> <start x="11508.125" y="694.7859"/> <end x="11738.875" y="774.0"/> </arc> <arc class="production" id="addprod_468d8cc8-7de8-4e74-a8d4-3742490f0a1a" source="pr_f4dc6ed9-35c1-4f47-8b11-e4fabb2b73cf_p2" target="wnc1_s_wnc2_s168_wnc1_wnc2_sa141"> <start x="11508.125" y="694.7859"/> <end x="11830.0" y="766.5"/> </arc> <arc class="consumption" id="cons_6bf25647-a7b3-4ed2-813b-f03a11c5ef78" source="wnc1_s_wnc2_s341_wnc1_wnc2_csa24" target="pr_6c39ed46-363d-4219-be53-b685959b4f66_p1"> <start x="11241.0" y="1461.5"/> <next x="11378.0" y="1119.0"/> <end x="11522.25" y="1070.3895"/> </arc> <arc class="consumption" id="cons_486db994-d9f0-4c43-9325-1a86ede16879" source="wnc1_s_wnc2_s183_wnc1_wnc2_sa151" target="pr_6c39ed46-363d-4219-be53-b685959b4f66_p1"> <start x="11361.0" y="1119.0"/> <next x="11378.0" y="1119.0"/> <end x="11522.25" y="1070.3895"/> </arc> <arc class="production" id="prod_2702fb5b-33bc-4c91-9145-c412b9fd799e" source="pr_6c39ed46-363d-4219-be53-b685959b4f66_p2" target="wnc1_s_wnc2_s185_wnc1_wnc2_csa26"> <start x="11552.25" y="1070.3895"/> <end x="11692.5" y="1023.0"/> </arc> <arc class="catalysis" id="modif_51ce4f91-a973-486b-9858-4d0722a95fe1" source="wnc1_s_wnc2_s183_wnc1_wnc2_sa151" target="pr_6c39ed46-363d-4219-be53-b685959b4f66"> <start x="11321.0" y="1099.0"/> <end x="11535.79" y="1065.6073"/> </arc> <arc class="consumption" id="addreact_ac910945-35ba-44f3-accf-8b087a299208" source="wnc1_s_wnc2_s134_wnc1_wnc2_sa127" target="pr_6c39ed46-363d-4219-be53-b685959b4f66_p1"> <start x="11713.875" y="799.0"/> <end x="11522.25" y="1070.3895"/> </arc> <arc class="consumption" id="addreact_a68816c9-695e-463f-83bb-f0d13262033e" source="wnc1_s_wnc2_s170_wnc1_wnc2_sa143" target="pr_6c39ed46-363d-4219-be53-b685959b4f66_p1"> <start x="11361.0" y="1006.0"/> <end x="11522.25" y="1070.3895"/> </arc> <arc class="consumption" id="cons_dfee5731-c2a9-496d-95f0-21e09a1d556c" source="wnc1_s_wnc2_s342_wnc1_wnc2_csa25" target="pr_383e13cc-e781-4252-925b-9914ca5a7b9b_p1"> <start x="11026.75" y="1429.0"/> <next x="11321.0" y="1403.5"/> <end x="11484.4375" y="1403.5"/> </arc> <arc class="consumption" id="cons_cef85286-99e3-496f-b504-7b21fa440a8a" source="wnc1_s_wnc2_s183_wnc1_wnc2_sa151" target="pr_383e13cc-e781-4252-925b-9914ca5a7b9b_p1"> <start x="11321.0" y="1139.0"/> <next x="11321.0" y="1403.5"/> <end x="11484.4375" y="1403.5"/> </arc> <arc class="production" id="prod_bf89acf5-3b2b-48b8-90b2-cbcf6108590b" source="pr_383e13cc-e781-4252-925b-9914ca5a7b9b_p2" target="wnc1_s_wnc2_s207_wnc1_wnc2_csa28"> <start x="11514.4375" y="1403.5"/> <end x="11673.875" y="1403.5"/> </arc> <arc class="catalysis" id="modif_55291ef7-dc38-497b-965b-efbf02d19b22" source="wnc1_s_wnc2_s183_wnc1_wnc2_sa151" target="pr_383e13cc-e781-4252-925b-9914ca5a7b9b"> <start x="11333.769" y="1139.0"/> <end x="11499.4375" y="1398.5"/> </arc> <arc class="consumption" id="addreact_3e3fe5c3-3c09-4ca0-aa4c-320c2afb1c0e" source="wnc1_s_wnc2_s170_wnc1_wnc2_sa143" target="pr_383e13cc-e781-4252-925b-9914ca5a7b9b_p1"> <start x="11321.0" y="1026.0"/> <end x="11484.4375" y="1403.5"/> </arc> <arc class="consumption" id="addreact_e85fbbca-b3ec-492f-b9ee-6c7163aa08aa" source="wnc1_s_wnc2_s134_wnc1_wnc2_sa127" target="pr_383e13cc-e781-4252-925b-9914ca5a7b9b_p1"> <start x="11713.875" y="799.0"/> <end x="11484.4375" y="1403.5"/> </arc> <arc class="consumption" id="cons_b407a6a1-52d4-4ab7-8017-f4af7dab8314" source="wnc1_s_wnc2_s336_wnc1_wnc2_csa6" target="pr_70819c4b-db5a-4399-9e05-2edbe28ea597_p1"> <start x="10467.0" y="927.0"/> <end x="10467.25" y="936.5"/> </arc> <arc class="production" id="prod_4e6b89f3-8913-4da6-9d13-84f10fb1bc4f" source="pr_70819c4b-db5a-4399-9e05-2edbe28ea597_p2" target="wnc1_s_wnc2_s337_wnc1_wnc2_csa29"> <start x="10467.25" y="966.5"/> <end x="10467.5" y="976.0"/> </arc> <arc class="catalysis" id="modif_d94987cf-56c7-403c-87a9-639cf7be6462" source="wnc1_s_wnc2_s206_wnc1_wnc2_csa30" target="pr_70819c4b-db5a-4399-9e05-2edbe28ea597"> <start x="10595.0" y="968.5"/> <end x="10472.25" y="951.449"/> </arc> <arc class="consumption" id="cons_3617b577-4462-45ce-9663-5b610dcfd6d2" source="wnc1_s_wnc2_s333_wnc1_wnc2_csa4" target="pr_92bd776a-d263-4608-a0ff-4d48991cf718_p1"> <start x="10428.0" y="555.0"/> <next x="10715.0" y="554.5"/> <end x="10747.25" y="554.5"/> </arc> <arc class="consumption" id="cons_2cd4e0cc-db9d-40b4-8156-a8cc26709193" source="wnc1_s_wnc2_s249_wnc1_wnc2_sa168" target="pr_92bd776a-d263-4608-a0ff-4d48991cf718_p1"> <start x="10715.0" y="512.0"/> <next x="10715.0" y="554.5"/> <end x="10747.25" y="554.5"/> </arc> <arc class="production" id="prod_9724db4a-fc9d-42eb-831b-98e01bb3c6ce" source="pr_92bd776a-d263-4608-a0ff-4d48991cf718_p2" target="wnc1_s_wnc2_s334_wnc1_wnc2_csa31"> <start x="10777.25" y="554.5"/> <end x="10805.5" y="554.5"/> </arc> <arc class="consumption" id="cons_c2972c27-1b21-4793-a611-5351ab5f7c85" source="wnc1_s_wnc2_s221_wnc1_wnc2_sa175" target="pr_166d688f-e7bd-4476-9cc2-463395c0efb0_p1"> <start x="11942.528" y="790.0"/> <end x="11818.389" y="844.25"/> </arc> <arc class="production" id="prod_01bd71a2-d0b6-4164-b354-b6ed74f752a0" source="pr_166d688f-e7bd-4476-9cc2-463395c0efb0_p2" target="wnc1_s_wnc2_s220_wnc1_wnc2_csa32"> <start x="11788.389" y="844.25"/> <end x="11664.25" y="898.5"/> </arc> <arc class="consumption" id="cons_6e4003eb-011f-4b62-8c14-07f2809112fb" source="wnc1_s_wnc2_s249_wnc1_wnc2_sa168" target="pr_01c69968-4537-4eca-af60-fb9fafb6a68a_p1"> <start x="10715.0" y="512.0"/> <next x="11570.0" y="989.0"/> <end x="11570.549" y="996.75"/> </arc> <arc class="consumption" id="cons_1bcf5699-a00c-46b9-8cf5-d8ab60676a0d" source="wnc1_s_wnc2_s220_wnc1_wnc2_csa32" target="pr_01c69968-4537-4eca-af60-fb9fafb6a68a_p1"> <start x="11570.75" y="961.0"/> <next x="11570.0" y="989.0"/> <end x="11570.549" y="996.75"/> </arc> <arc class="production" id="prod_c5e04572-49c8-4266-b3d7-a3ddc1436422" source="pr_01c69968-4537-4eca-af60-fb9fafb6a68a_p2" target="wnc1_s_wnc2_s223_wnc1_wnc2_csa33"> <start x="11570.549" y="1026.75"/> <end x="11571.0" y="1030.5"/> </arc> <arc class="consumption" id="cons_a1764a71-6cd8-430e-971f-5618c30e2b8b" source="wnc1_s_wnc2_s220_wnc1_wnc2_csa32" target="pr_f9cb0cfe-dd7b-4692-b5c2-2e499c0417c9_p1"> <start x="11477.25" y="898.5"/> <end x="11466.4375" y="898.75"/> </arc> <arc class="production" id="prod_97d7c204-481b-430e-96aa-8683e8ac1634" source="pr_f9cb0cfe-dd7b-4692-b5c2-2e499c0417c9_p2" target="wnc1_s_wnc2_s281_wnc1_wnc2_csa34"> <start x="11436.4375" y="898.75"/> <end x="11425.625" y="899.0"/> </arc> <arc class="catalysis" id="modif_5933485b-bc6b-4334-bf09-e9134fa76aeb" source="wnc1_s_wnc2_s336_wnc1_wnc2_csa6" target="pr_f9cb0cfe-dd7b-4692-b5c2-2e499c0417c9"> <start x="10518.0" y="819.0"/> <end x="11451.389" y="893.75024"/> </arc> <arc class="consumption" id="cons_7f9f6b31-e73f-458b-87e6-19acce55972c" source="wnc1_s_wnc2_s227_wnc1_wnc2_sa183" target="pr_9c41e23c-0453-47e9-8b01-5bd54b0c0cca_p1"> <start x="10016.0" y="1771.0"/> <end x="10005.25" y="1771.0"/> </arc> <arc class="production" id="prod_0663bc8e-2252-43fe-bb42-ce6740309a6e" source="pr_9c41e23c-0453-47e9-8b01-5bd54b0c0cca_p2" target="wnc1_s_wnc2_s229_wnc1_wnc2_sa184"> <start x="9975.25" y="1771.0"/> <end x="9964.5" y="1771.0"/> </arc> <arc class="catalysis" id="modif_bdc7cfad-ddd1-43e9-8a1a-eeab8e471b52" source="wnc1_s_wnc2_s19_wnc1_wnc2_sa12" target="pr_9c41e23c-0453-47e9-8b01-5bd54b0c0cca"> <start x="11386.0" y="548.0"/> <end x="9990.25" y="1766.0"/> </arc> <arc class="consumption" id="cons_3b846801-149e-4b3b-baea-26b203f614a8" source="wnc1_s_wnc2_s103_wnc1_wnc2_sa81" target="pr_c1f8116d-e294-4392-bf06-4b3d02268d81_p1"> <start x="10822.0" y="821.0"/> <next x="10194.0" y="1771.0"/> <end x="10204.726" y="1773.5"/> </arc> <arc class="consumption" id="cons_9260bae8-e070-4dae-931e-36d60ab35210" source="wnc1_s_wnc2_s227_wnc1_wnc2_sa183" target="pr_c1f8116d-e294-4392-bf06-4b3d02268d81_p1"> <start x="10096.0" y="1771.0"/> <next x="10194.0" y="1771.0"/> <end x="10204.726" y="1773.5"/> </arc> <arc class="production" id="prod_985055ce-dc9c-4270-9c25-7db23e153183" source="pr_c1f8116d-e294-4392-bf06-4b3d02268d81_p2" target="wnc1_s_wnc2_s231_wnc1_wnc2_csa35"> <start x="10204.726" y="1803.5"/> <end x="10213.0" y="1802.0"/> </arc> <arc class="consumption" id="cons_182aed32-ff6e-49f4-bdf3-8d8e7c17274b" source="wnc1_s_wnc2_s235_wnc1_wnc2_sa187" target="pr_c6946c48-62c5-4e84-99a0-97377bf8ecb2_p1"> <start x="11163.0" y="2088.0"/> <end x="11193.25" y="2088.0"/> </arc> <arc class="production" id="prod_5766c826-a798-445d-9249-94a945b0d18c" source="pr_c6946c48-62c5-4e84-99a0-97377bf8ecb2_p2" target="wnc1_s_wnc2_s244_wnc1_wnc2_sa194"> <start x="11223.25" y="2088.0"/> <end x="11253.5" y="2088.0"/> </arc> <arc class="catalysis" id="modif_a62fa468-8b59-4703-aeb4-e60fe81e84d3" source="wnc1_s_wnc2_s242_wnc1_wnc2_sa195" target="pr_c6946c48-62c5-4e84-99a0-97377bf8ecb2"> <start x="11208.0" y="2138.0"/> <end x="11208.25" y="2093.0"/> </arc> <arc class="consumption" id="cons_46f66e93-4c67-4f8e-84da-4bc0a8c21f16" source="wnc1_s_wnc2_s244_wnc1_wnc2_sa194" target="pr_f49c13d5-b26c-44b7-822f-46b0d8bde359_p1"> <start x="11333.5" y="2088.0"/> <end x="11374.0" y="2088.0"/> </arc> <arc class="production" id="prod_30379579-c583-4995-8172-0f2a32e41ece" source="pr_f49c13d5-b26c-44b7-822f-46b0d8bde359_p2" target="wnc1_s_wnc2_s245_wnc1_wnc2_sa196"> <start x="11404.0" y="2088.0"/> <end x="11444.5" y="2088.0"/> </arc> <arc class="catalysis" id="modif_0c8fb8c0-d660-4d12-85bc-8fe3dfd9a3fb" source="wnc1_s_wnc2_s246_wnc1_wnc2_sa197" target="pr_f49c13d5-b26c-44b7-822f-46b0d8bde359"> <start x="11387.0" y="2037.0"/> <end x="11389.0" y="2083.0"/> </arc> <arc class="catalysis" id="modif_ecdc974e-b78d-4452-ac48-3a7b2f2d6bf6" source="wnc1_s_wnc2_s247_wnc1_wnc2_sa198" target="pr_f49c13d5-b26c-44b7-822f-46b0d8bde359"> <start x="11391.0" y="2147.0"/> <end x="11389.0" y="2093.0"/> </arc> <arc class="consumption" id="cons_3502ab46-1222-4657-a8df-bbf470861248" source="wnc1_s_wnc2_s245_wnc1_wnc2_sa196" target="pr_1d972708-4b4b-49a0-b8a5-dcce4b19bbf7_p1"> <start x="11484.5" y="2068.0"/> <end x="11502.0" y="1853.5"/> </arc> <arc class="production" id="prod_a04bfa23-2147-4154-8d39-fc71b58b5af4" source="pr_1d972708-4b4b-49a0-b8a5-dcce4b19bbf7_p2" target="wnc1_s_wnc2_s103_wnc1_wnc2_sa199"> <start x="11502.0" y="1823.5"/> <end x="11519.5" y="1609.0"/> </arc> <arc class="catalysis" id="modif_83685132-60f5-4e08-8c83-f24d6fcfdec9" source="wnc1_s_wnc2_s278_wnc1_wnc2_sa221" target="pr_1d972708-4b4b-49a0-b8a5-dcce4b19bbf7"> <start x="11586.0" y="1840.0"/> <end x="11506.985" y="1838.8801"/> </arc> <arc class="consumption" id="cons_8800e0b6-b52d-4625-b95b-628d02f24b84" source="wnc1_s_wnc2_s103_wnc1_wnc2_sa199" target="pr_58e1f1f7-ee4f-4b4d-b687-120ef47ede2d_p1"> <start x="11519.5" y="1569.0"/> <end x="11568.25" y="1136.0"/> </arc> <arc class="production" id="prod_fe79def9-2de6-4834-a7cf-f108f146c463" source="pr_58e1f1f7-ee4f-4b4d-b687-120ef47ede2d_p2" target="wnc1_s_wnc2_s163_wnc1_wnc2_csa27"> <start x="11568.25" y="1106.0"/> <end x="11617.0" y="673.0"/> </arc> <arc class="consumption" id="cons_c50bfb2c-9d7c-4991-9e06-a7c59e8441ca" source="wnc1_s_wnc2_s211_wnc1_wnc2_sa200" target="pr_c6c11c15-c70e-4258-807f-b9e1b0302df4_p1"> <start x="10569.0" y="1555.0"/> <end x="10632.0" y="1048.5"/> </arc> <arc class="production" id="prod_221bf627-2acb-41fe-ac38-a06378cc5170" source="pr_c6c11c15-c70e-4258-807f-b9e1b0302df4_p2" target="wnc1_s_wnc2_s249_wnc1_wnc2_sa168"> <start x="10632.0" y="1018.5"/> <end x="10695.0" y="512.0"/> </arc> <arc class="catalysis" id="modif_4eaf7d95-3791-43fa-9370-90d2dd938681" source="wnc1_s_wnc2_s166_wnc1_wnc2_sa139" target="pr_c6c11c15-c70e-4258-807f-b9e1b0302df4"> <start x="11483.625" y="786.5"/> <end x="10636.964" y="1034.0996"/> </arc> <arc class="consumption" id="cons_c25e0c6b-37e3-45fb-93d7-9f5cc7e689f4" source="wnc1_s_wnc2_s211_wnc1_wnc2_sa200" target="pr_9efef8bc-8af7-4884-bc0a-80b3f4c092e7_p1"> <start x="10569.0" y="1595.0"/> <end x="10569.0" y="1621.0"/> </arc> <arc class="production" id="prod_fe3b793e-7f66-4ac9-8675-dcabfe6013d5" source="pr_9efef8bc-8af7-4884-bc0a-80b3f4c092e7_p2" target="wnc1_s_wnc2_s252_wnc1_wnc2_sa201"> <start x="10569.0" y="1651.0"/> <end x="10569.0" y="1677.0"/> </arc> <arc class="catalysis" id="logicarc_ff75835c-4551-4380-8c12-b8122c96d75d" source="logicglyph_64fb4fd2-7ea7-45b7-81cc-7b9479533ead_p2" target="pr_9efef8bc-8af7-4884-bc0a-80b3f4c092e7"> <start x="10918.666" y="1344.3334"/> <end x="10574.0" y="1636.0"/> </arc> <arc class="logic arc" id="modif_c66d9683-df9b-4937-aca7-c4f7c81258b1" source="wnc1_s_wnc2_s166_wnc1_wnc2_sa139" target="logicglyph_64fb4fd2-7ea7-45b7-81cc-7b9479533ead_p1"> <start x="11523.625" y="806.5"/> <end x="10958.666" y="1344.3334"/> </arc> <arc class="logic arc" id="modif_c236bd70-0d2f-498a-9979-cca4f0a70954" source="wnc1_s_wnc2_s253_wnc1_wnc2_sa202" target="logicglyph_64fb4fd2-7ea7-45b7-81cc-7b9479533ead_p1"> <start x="10723.0" y="1551.0"/> <end x="10958.666" y="1344.3334"/> </arc> <arc class="consumption" id="cons_3812af0e-0905-4836-92c8-0458ddedacf7" source="wnc1_s_wnc2_s252_wnc1_wnc2_sa201" target="pr_ddcc210f-fb33-4314-8f7e-eca7a4283a4a_p1"> <start x="10569.0" y="1717.0"/> <end x="10569.0" y="1729.5"/> </arc> <arc class="production" id="prod_8638fe73-2910-4186-895c-ad6ed675ed5a" source="pr_ddcc210f-fb33-4314-8f7e-eca7a4283a4a_p2" target="wnc1_s_wnc2_s255_wnc1_wnc2_sa203"> <start x="10569.0" y="1759.5"/> <end x="10569.0" y="1772.0"/> </arc> <arc class="catalysis" id="modif_0ecb0a67-3185-4b92-bd66-c427529b008f" source="wnc1_s_wnc2_s168_wnc1_wnc2_sa141" target="pr_ddcc210f-fb33-4314-8f7e-eca7a4283a4a"> <start x="11830.0" y="806.5"/> <end x="10574.0" y="1744.5"/> </arc> <arc class="consumption" id="cons_ce379c66-d72c-4292-bb39-c381ee2994da" source="wnc1_s_wnc2_s256_wnc1_wnc2_sa204" target="pr_3708a75d-c5fc-4c10-9ce5-d3e88c1423ec_p1"> <start x="10724.0" y="1475.0"/> <end x="10723.5" y="1498.0"/> </arc> <arc class="production" id="prod_dd6a368a-2bdd-4141-a1fd-8d18a8e4df81" source="pr_3708a75d-c5fc-4c10-9ce5-d3e88c1423ec_p2" target="wnc1_s_wnc2_s253_wnc1_wnc2_sa202"> <start x="10723.5" y="1528.0"/> <end x="10723.0" y="1551.0"/> </arc> <arc class="consumption" id="cons_53b696be-3777-4db1-ae1a-a55c600d5980" source="wnc1_s_wnc2_s339_wnc1_wnc2_csa23" target="pr_bfe04d09-db0e-4aa1-b97b-df5609318b37_p1"> <start x="11152.25" y="2005.5"/> <end x="11144.088" y="2005.5"/> </arc> <arc class="production" id="prod_e7dc3299-053c-413b-9874-1f3c1045738c" source="pr_bfe04d09-db0e-4aa1-b97b-df5609318b37_p2" target="wnc1_s_wnc2_s235_wnc1_wnc2_sa187"> <start x="11144.088" y="2035.5"/> <next x="11135.927" y="2035.5"/> <end x="11123.0" y="2068.0"/> </arc> <arc class="production" id="prod_597cddc7-0b19-40fe-96c4-27a9064c233a" source="pr_bfe04d09-db0e-4aa1-b97b-df5609318b37_p2" target="wnc1_s_wnc2_s241_wnc1_wnc2_sa193"> <start x="11144.088" y="2035.5"/> <next x="11135.927" y="2035.5"/> <end x="11503.75" y="1813.0"/> </arc> <arc class="production" id="addprod_3f813e6d-ae9f-4d38-b570-f150e6189d9f" source="pr_bfe04d09-db0e-4aa1-b97b-df5609318b37_p2" target="wnc1_s_wnc2_s340_wnc1_wnc2_csa37"> <start x="11144.088" y="2035.5"/> <end x="11321.0" y="1826.5"/> </arc> <arc class="production" id="addprod_0dcf9c20-b69c-4ba0-89e1-c3297e1d2744" source="pr_bfe04d09-db0e-4aa1-b97b-df5609318b37_p2" target="wnc1_s_wnc2_s240_wnc1_wnc2_sa192"> <start x="11144.088" y="2035.5"/> <end x="11463.75" y="1751.0"/> </arc> <arc class="consumption" id="cons_51f801cc-c5e2-4784-b1d4-ae625bc6cb11" source="wnc1_s_wnc2_s260_wnc1_wnc2_sa205" target="pr_8291c9af-4ba0-412d-afc8-a08ca4363bcf_p1"> <start x="10467.0" y="1968.0"/> <end x="10490.75" y="1968.0"/> </arc> <arc class="production" id="prod_06558c96-186d-4d3d-887d-7921ad960e10" source="pr_8291c9af-4ba0-412d-afc8-a08ca4363bcf_p2" target="wnc1_s_wnc2_s258_wnc1_wnc2_sa206"> <start x="10520.75" y="1968.0"/> <end x="10544.5" y="1968.0"/> </arc> <arc class="catalysis" id="modif_7c794630-54b2-434d-8f54-954643b5d890" source="wnc1_s_wnc2_s336_wnc1_wnc2_csa6" target="pr_8291c9af-4ba0-412d-afc8-a08ca4363bcf"> <start x="10416.0" y="819.0"/> <end x="10510.75" y="1963.0"/> </arc> <arc class="catalysis" id="modif_a752cf8f-bea1-4cec-bec2-354b4c8ecb79" source="wnc1_s_wnc2_s41_wnc1_wnc2_csa7" target="pr_8291c9af-4ba0-412d-afc8-a08ca4363bcf"> <start x="10258.0" y="775.0"/> <end x="10500.75" y="1963.0"/> </arc> <arc class="consumption" id="cons_8008dec5-f95c-49bd-b506-28c165354d0c" source="wnc1_s_wnc2_s258_wnc1_wnc2_sa206" target="pr_56c2974b-7a66-47f8-b9f8-077bcc1244a7_p1"> <start x="10624.5" y="1968.0"/> <end x="10675.5" y="1968.0"/> </arc> <arc class="production" id="prod_2424a21a-f033-4c3b-be6b-b7c7c67a1335" source="pr_56c2974b-7a66-47f8-b9f8-077bcc1244a7_p2" target="wnc1_s_wnc2_s261_wnc1_wnc2_sa207"> <start x="10705.5" y="1968.0"/> <end x="10756.5" y="1968.0"/> </arc> <arc class="consumption" id="cons_4c996222-c2b4-46e2-a1d0-649cfce3bb86" source="wnc1_s_wnc2_s333_wnc1_wnc2_csa4" target="pr_f31eee29-4467-4a0a-9672-bdea45ad33d1_p1"> <start x="10378.0" y="615.0"/> <end x="10289.75" y="1291.5"/> </arc> <arc class="production" id="prod_990c2b40-a9fc-4156-b428-b420352b702d" source="pr_f31eee29-4467-4a0a-9672-bdea45ad33d1_p2" target="wnc1_s_wnc2_s338_wnc1_wnc2_csa39"> <start x="10289.75" y="1321.5"/> <end x="10201.5" y="1998.0"/> </arc> <arc class="catalysis" id="logicarc_e77c4863-eb55-402e-a8e9-7431a2f9149e" source="logicglyph_1579d8a2-095e-4d09-8f9a-9eeefec54991_p2" target="pr_f31eee29-4467-4a0a-9672-bdea45ad33d1"> <start x="10099.0" y="1944.0"/> <end x="10284.79" y="1305.8671"/> </arc> <arc class="logic arc" id="modif_b21c943a-3e1e-4be4-99d6-2357fc59f6bf" source="wnc1_s_wnc2_s262_wnc1_wnc2_sa208" target="logicglyph_1579d8a2-095e-4d09-8f9a-9eeefec54991_p1"> <start x="10009.0" y="1892.0"/> <end x="10099.0" y="1984.0"/> </arc> <arc class="logic arc" id="modif_59c387ed-b783-4f20-ab8a-efa778ca1782" source="wnc1_s_wnc2_s263_wnc1_wnc2_sa209" target="logicglyph_1579d8a2-095e-4d09-8f9a-9eeefec54991_p1"> <start x="10009.0" y="1943.0"/> <end x="10099.0" y="1984.0"/> </arc> <arc class="logic arc" id="modif_ba3190ec-77dd-42dd-9dac-3628ecd0ca22" source="wnc1_s_wnc2_s268_wnc1_wnc2_csa38" target="logicglyph_1579d8a2-095e-4d09-8f9a-9eeefec54991_p1"> <start x="10084.0" y="2090.5"/> <end x="10099.0" y="1984.0"/> </arc> <arc class="consumption" id="cons_32feb12d-5907-44b6-952d-eabd8e0da936" source="wnc1_s_wnc2_s338_wnc1_wnc2_csa39" target="pr_e0ee62f2-3218-4d2a-8353-7ba4fb104c72_p1"> <start x="10251.5" y="2058.0"/> <end x="10261.75" y="2058.0"/> </arc> <arc class="production" id="prod_a89936ce-9e92-46d1-a7d8-4ca61a03c32c" source="pr_e0ee62f2-3218-4d2a-8353-7ba4fb104c72_p2" target="wnc1_s_wnc2_s272_wnc1_wnc2_sa216"> <start x="10291.75" y="2058.0"/> <end x="10302.0" y="2058.0"/> </arc> <arc class="consumption" id="cons_7093592a-5083-4d45-b55c-0413b0a8c836" source="wnc1_s_wnc2_s103_wnc1_wnc2_sa81" target="pr_a980bfc9-53bd-44d4-82b7-e46c3e51053b_p1"> <start x="10822.0" y="821.0"/> <end x="10759.5" y="1031.0"/> </arc> <arc class="production" id="prod_a25a461b-14d2-476f-ad0d-df1ecdd438e3" source="pr_a980bfc9-53bd-44d4-82b7-e46c3e51053b_p2" target="wnc1_s_wnc2_s273_wnc1_wnc2_sa217"> <start x="10759.5" y="1061.0"/> <end x="10697.0" y="1271.0"/> </arc> <arc class="catalysis" id="modif_1d10eeec-2b94-41c3-a979-b4e9d6c375f0" source="wnc1_s_wnc2_s274_wnc1_wnc2_sa218" target="pr_a980bfc9-53bd-44d4-82b7-e46c3e51053b"> <start x="10812.0" y="1268.0"/> <end x="10764.317" y="1047.3383"/> </arc> <arc class="consumption" id="cons_838d28a4-3d04-4e3b-898d-3bc6c5896d42" source="wnc1_s_wnc2_s276_wnc1_wnc2_sa219" target="pr_fc2d995c-8f32-4092-b504-c052a8da4131_p1"> <start x="10406.5" y="2061.0"/> <end x="10384.25" y="2059.7515"/> </arc> <arc class="production" id="prod_6820ab8e-58d1-474a-ada2-d107ab18b70f" source="pr_fc2d995c-8f32-4092-b504-c052a8da4131_p2" target="wnc1_s_wnc2_s272_wnc1_wnc2_sa216"> <start x="10354.25" y="2059.7515"/> <end x="10332.0" y="2058.5027"/> </arc> <arc class="consumption" id="cons_9485e7af-dc64-49f7-8f52-a73cc3c2c2a9" source="wnc1_s_wnc2_s103_wnc1_wnc2_sa81" target="pr_8fbea444-f1ba-4783-890b-e27f8120fa5a_p1"> <start x="10822.0" y="821.0"/> <end x="10634.25" y="1416.0"/> </arc> <arc class="production" id="prod_074bcfdb-64ed-42ec-bd19-15b7d2798868" source="pr_8fbea444-f1ba-4783-890b-e27f8120fa5a_p2" target="wnc1_s_wnc2_s276_wnc1_wnc2_sa219"> <start x="10634.25" y="1446.0"/> <end x="10446.5" y="2041.0"/> </arc> <arc class="catalysis" id="logicarc_74201dbf-da59-4e00-8a87-7ef3099c3fd2" source="logicglyph_2cc685f1-511d-452d-a757-bc8224a7e671_p2" target="pr_8fbea444-f1ba-4783-890b-e27f8120fa5a"> <start x="10261.75" y="1796.5"/> <end x="10629.472" y="1429.5292"/> </arc> <arc class="logic arc" id="modif_fef70367-0692-4221-99ae-e40d9b668d0f" source="wnc1_s_wnc2_s262_wnc1_wnc2_sa208" target="logicglyph_2cc685f1-511d-452d-a757-bc8224a7e671_p1"> <start x="10009.0" y="1892.0"/> <end x="10221.75" y="1796.5"/> </arc> <arc class="logic arc" id="modif_b96e0b89-782d-4589-aab6-554c74b8a9b9" source="wnc1_s_wnc2_s263_wnc1_wnc2_sa209" target="logicglyph_2cc685f1-511d-452d-a757-bc8224a7e671_p1"> <start x="10009.0" y="1943.0"/> <end x="10221.75" y="1796.5"/> </arc> <arc class="logic arc" id="modif_6ecb62f0-b1f4-4d2f-9967-f622989ed0f2" source="wnc1_s_wnc2_s277_wnc1_wnc2_sa220" target="logicglyph_2cc685f1-511d-452d-a757-bc8224a7e671_p1"> <start x="10291.0" y="1898.0"/> <end x="10221.75" y="1796.5"/> </arc> <arc class="consumption" id="cons_ca369074-4840-481b-b207-229b9c49850c" source="wnc1_s_wnc2_s302_wnc1_wnc2_csa41" target="pr_8b054de9-b847-4636-a2f9-35ae05ad715f_p1"> <start x="9831.0" y="2191.0"/> <end x="9831.0" y="2203.0"/> </arc> <arc class="production" id="prod_ebfeae89-2483-4be9-931f-c9542eccb797" source="pr_8b054de9-b847-4636-a2f9-35ae05ad715f_p2" target="wnc1_s_wnc2_s303_wnc1_wnc2_csa42"> <start x="9831.0" y="2233.0"/> <end x="9831.0" y="2245.0"/> </arc> <arc class="catalysis" id="modif_83d26318-11af-4df3-81b4-9c1ad6f75ce1" source="wnc1_s_wnc2_s220_wnc1_wnc2_csa32" target="pr_8b054de9-b847-4636-a2f9-35ae05ad715f"> <start x="11570.75" y="961.0"/> <end x="9836.0" y="2218.0"/> </arc> <arc class="consumption" id="cons_7b500dc7-b497-47c3-a95b-48cd642c49db" source="wnc1_s_wnc2_s220_wnc1_wnc2_csa32" target="pr_3e47296b-f0df-4975-9f7c-2e39589bfe60_p1"> <start x="11570.75" y="961.0"/> <next x="9840.5" y="2421.5"/> <end x="9843.922" y="2435.75"/> </arc> <arc class="consumption" id="cons_349dc50a-937c-4ef5-8e0d-4da9f6c1067d" source="wnc1_s_wnc2_s303_wnc1_wnc2_csa42" target="pr_3e47296b-f0df-4975-9f7c-2e39589bfe60_p1"> <start x="9831.0" y="2384.0"/> <next x="9840.5" y="2421.5"/> <end x="9843.922" y="2435.75"/> </arc> <arc class="production" id="prod_f90e445d-bf89-42cb-ac77-c6ac4c448b38" source="pr_3e47296b-f0df-4975-9f7c-2e39589bfe60_p2" target="wnc1_s_wnc2_s293_wnc1_wnc2_csa40"> <start x="9843.922" y="2465.75"/> <end x="9846.875" y="2476.0"/> </arc> <arc class="inhibition" id="direct_47d825d1-ce1c-4414-816f-9191837f0489" source="wnc1_s_wnc2_s293_wnc1_wnc2_csa40" target="wnc1_s_wnc2_s294_wnc1_wnc2_sa229"> <start x="10062.125" y="2548.5"/> <end x="10135.0" y="2553.9878"/> </arc> <arc class="consumption" id="cons_24ecbf8f-0d29-40dd-a431-fc1ec9f6eb3a" source="wnc1_s_wnc2_s296_wnc1_wnc2_sa231" target="pr_ba10ee94-176c-453a-9d7a-78cbb86a3dfa_p1"> <start x="9751.0" y="1908.5"/> <next x="9771.5" y="2020.0"/> <end x="9788.25" y="2037.0757"/> </arc> <arc class="consumption" id="cons_a51cd803-86af-477a-9401-b0879b8ec7ef" source="wnc1_s_wnc2_s279_wnc1_wnc2_sa230" target="pr_ba10ee94-176c-453a-9d7a-78cbb86a3dfa_p1"> <start x="9825.0" y="1971.0"/> <next x="9771.5" y="2020.0"/> <end x="9788.25" y="2037.0757"/> </arc> <arc class="production" id="prod_32901745-352f-4cfb-82e3-60ee88819655" source="pr_ba10ee94-176c-453a-9d7a-78cbb86a3dfa_p2" target="wnc1_s_wnc2_s302_wnc1_wnc2_csa41"> <start x="9818.25" y="2037.0757"/> <end x="9831.0" y="2052.0"/> </arc> <arc class="consumption" id="addreact_9dbefa81-2caf-469f-a29c-ee8671a0f828" source="wnc1_s_wnc2_s300_wnc1_wnc2_sa233" target="pr_ba10ee94-176c-453a-9d7a-78cbb86a3dfa_p1"> <start x="9820.093" y="1920.0"/> <end x="9788.25" y="2037.0757"/> </arc> <arc class="consumption" id="cons_3832a185-ef56-474d-9f68-03f60e204ade" source="wnc1_s_wnc2_s308_wnc1_wnc2_sa238" target="pr_b2f92522-dc9e-4a21-b68b-84758db0263a_p1"> <start x="9930.0" y="1084.0"/> <end x="9930.0" y="1073.0"/> </arc> <arc class="production" id="prod_95646bff-a4ff-4790-8c31-66ed90cb4f25" source="pr_b2f92522-dc9e-4a21-b68b-84758db0263a_p2" target="wnc1_s_wnc2_s307_wnc1_wnc2_sa239"> <start x="9930.0" y="1043.0"/> <end x="9930.0" y="1032.0"/> </arc> <arc class="catalysis" id="modif_0fb39dce-d82e-496c-b5e6-7d6e4d9d5b93" source="wnc1_s_wnc2_s41_wnc1_wnc2_csa7" target="pr_b2f92522-dc9e-4a21-b68b-84758db0263a"> <start x="10258.0" y="805.0"/> <end x="9935.0" y="1058.0"/> </arc> <arc class="stimulation" id="direct_3eed1aa1-0f5e-4810-b399-5213666b53b7" source="wnc1_s_wnc2_s307_wnc1_wnc2_sa239" target="wnc1_s_wnc2_s309_wnc1_wnc2_sa240"> <start x="9930.0" y="992.0"/> <end x="9901.13" y="935.0"/> </arc> <arc class="stimulation" id="direct_9db72297-dd36-4d09-a252-e8da067a90c1" source="wnc1_s_wnc2_s307_wnc1_wnc2_sa239" target="wnc1_s_wnc2_s310_wnc1_wnc2_sa241"> <start x="9930.0" y="992.0"/> <end x="9979.598" y="935.0"/> </arc> <arc class="stimulation" id="direct_d64a06e1-4b24-4807-9efc-85d3efe1f856" source="wnc1_s_wnc2_s309_wnc1_wnc2_sa240" target="wnc1_s_wnc2_s57_wnc1_wnc2_sa45"> <start x="9895.082" y="935.0"/> <end x="9977.938" y="1341.0"/> </arc> <arc class="stimulation" id="direct_ecef9601-ca0f-4424-b8e7-f577dd714594" source="wnc1_s_wnc2_s310_wnc1_wnc2_sa241" target="wnc1_s_wnc2_s57_wnc1_wnc2_sa45"> <start x="9996.274" y="935.0"/> <end x="9981.544" y="1341.0"/> </arc> <arc class="consumption" id="cons_6488e47c-a335-4141-858a-5346bc1e1e91" source="wnc1_s_wnc2_s109_wnc1_wnc2_csa19" target="pr_df20e3ca-ea79-4fd8-8fc4-682c5c2bd1f8_p1"> <start x="10953.25" y="926.0"/> <end x="10953.25" y="885.0"/> </arc> <arc class="production" id="prod_75929be2-398d-4452-859d-3c4a2910223d" source="pr_df20e3ca-ea79-4fd8-8fc4-682c5c2bd1f8_p2" target="wnc1_s_wnc2_s105_wnc1_wnc2_csa18"> <start x="10953.25" y="855.0"/> <end x="10953.25" y="814.0"/> </arc> <arc class="catalysis" id="modif_c4b9bd3a-9cc0-4517-bad6-75e03d9d2deb" source="wnc1_s_wnc2_s310_wnc1_wnc2_sa241" target="pr_df20e3ca-ea79-4fd8-8fc4-682c5c2bd1f8"> <start x="10037.0" y="915.0"/> <end x="10948.25" y="875.0"/> </arc> <arc class="catalysis" id="modif_0d079e21-1683-4508-b56f-b64d7535e59d" source="wnc1_s_wnc2_s309_wnc1_wnc2_sa240" target="pr_df20e3ca-ea79-4fd8-8fc4-682c5c2bd1f8"> <start x="9931.0" y="905.0"/> <end x="10948.25" y="865.0"/> </arc> <arc class="consumption" id="cons_450e4a24-eb77-458e-b2c5-e38f1fee20ab" source="wnc1_s_wnc2_s310_wnc1_wnc2_sa241" target="pr_c26fadb0-f859-402f-ae69-ff1110cfe1b7_p1"> <start x="10037.0" y="915.0"/> <end x="10356.046" y="1180.0"/> </arc> <arc class="production" id="prod_6c894db0-3f54-4fb6-a930-bd14ed027648" source="pr_c26fadb0-f859-402f-ae69-ff1110cfe1b7_p2" target="wnc1_s_wnc2_s256_wnc1_wnc2_sa204"> <start x="10386.046" y="1180.0"/> <end x="10705.092" y="1445.0"/> </arc> <arc class="consumption" id="cons_f2701ca4-7a03-4d52-8569-aa399fac91bc" source="wnc1_s_wnc2_s309_wnc1_wnc2_sa240" target="pr_a6fe4db4-fc95-42fe-9dc0-de528724d2f6_p1"> <start x="9921.568" y="935.0"/> <end x="10296.32" y="1190.0"/> </arc> <arc class="production" id="prod_2a822e90-dab8-4c6a-8959-b2f583f47323" source="pr_a6fe4db4-fc95-42fe-9dc0-de528724d2f6_p2" target="wnc1_s_wnc2_s256_wnc1_wnc2_sa204"> <start x="10326.32" y="1190.0"/> <end x="10701.073" y="1445.0"/> </arc> <arc class="consumption" id="cons_5de6a73b-55dd-44b9-9cb5-1769caf4f715" source="wnc1_s_wnc2_s235_wnc1_wnc2_sa187" target="pr_40b9a772-95ec-496b-9a70-a035d98d5b6b_p1"> <start x="11083.0" y="2088.0"/> <end x="11066.0" y="2088.0"/> </arc> <arc class="production" id="prod_c23c5fc4-ce9d-4ad6-8832-a00c0e52ded3" source="pr_40b9a772-95ec-496b-9a70-a035d98d5b6b_p2" target="wnc1_s_wnc2_s314_wnc1_wnc2_sa242"> <start x="11036.0" y="2088.0"/> <end x="11019.0" y="2088.0"/> </arc> <arc class="catalysis" id="modif_3d97f604-98d6-4018-90d1-586192c2e2bf" source="wnc1_s_wnc2_s330_wnc1_wnc2_csa47" target="pr_40b9a772-95ec-496b-9a70-a035d98d5b6b"> <start x="11538.0" y="1975.0"/> <end x="11051.0" y="2093.0"/> </arc> <arc class="consumption" id="cons_8aa03760-165a-45ff-8ca2-89f50a946e91" source="wnc1_s_wnc2_s314_wnc1_wnc2_sa242" target="pr_55e66882-a975-40d8-b493-879f06dad557_p1"> <start x="10939.0" y="2088.0"/> <next x="10904.5" y="2128.5"/> <end x="10903.25" y="2128.5"/> </arc> <arc class="consumption" id="cons_72495390-5802-4514-90d2-fe7fce36a2e1" source="wnc1_s_wnc2_s316_wnc1_wnc2_sa244" target="pr_55e66882-a975-40d8-b493-879f06dad557_p1"> <start x="10926.0" y="2171.0"/> <next x="10904.5" y="2128.5"/> <end x="10903.25" y="2128.5"/> </arc> <arc class="production" id="prod_7ce0d667-68f2-4761-9800-bd124a95d8c9" source="pr_55e66882-a975-40d8-b493-879f06dad557_p2" target="wnc1_s_wnc2_s319_wnc1_wnc2_csa43"> <start x="10873.25" y="2128.5"/> <end x="10876.0" y="2128.5"/> </arc> <arc class="consumption" id="cons_2877b24f-94b4-4d2d-b313-44da37f37bdc" source="wnc1_s_wnc2_s319_wnc1_wnc2_csa43" target="pr_4e08bd19-b83f-4da6-87c2-b9e4a6524bc2_p1"> <start x="10769.0" y="2128.5"/> <end x="10722.5" y="2128.75"/> </arc> <arc class="production" id="prod_379c56cf-a29a-45ba-ab83-1b19d6765b37" source="pr_4e08bd19-b83f-4da6-87c2-b9e4a6524bc2_p2" target="wnc1_s_wnc2_s322_wnc1_wnc2_csa44"> <start x="10692.5" y="2128.75"/> <end x="10646.0" y="2129.0"/> </arc> <arc class="catalysis" id="modif_d1fdece2-9fbe-4035-a28b-d61b92fca7dd" source="wnc1_s_wnc2_s278_wnc1_wnc2_sa249" target="pr_4e08bd19-b83f-4da6-87c2-b9e4a6524bc2"> <start x="10784.0" y="2047.0"/> <end x="10707.4795" y="2123.75"/> </arc> <arc class="consumption" id="cons_5ae7cc08-3e93-464b-b957-c3b2072be0f7" source="wnc1_s_wnc3_s1_wnc1_wnc3_sa1" target="pr_f447db86-d8cf-4163-9656-a954cfed100c_p1"> <start x="7763.0" y="3246.0"/> <end x="7772.5" y="3246.3984"/> </arc> <arc class="production" id="prod_94ff756b-5873-4f7d-8d5b-8a8a12e604b7" source="pr_f447db86-d8cf-4163-9656-a954cfed100c_p2" target="wnc1_s_wnc3_s2_wnc1_wnc3_sa2"> <start x="7802.5" y="3246.3984"/> <end x="7812.0" y="3246.7966"/> </arc> <arc class="catalysis" id="modif_f68e51bc-bec4-4a0e-b5ec-5fb468c7bfe5" source="wnc1_s_wnc3_s4_wnc1_wnc3_sa4" target="pr_f447db86-d8cf-4163-9656-a954cfed100c"> <start x="7793.0" y="3192.0"/> <end x="7787.581" y="3241.3992"/> </arc> <arc class="catalysis" id="modif_4842cb51-d39e-44fd-b4e9-592765bc113e" source="wnc1_s_wnc3_s10_wnc1_wnc3_sa10" target="pr_f447db86-d8cf-4163-9656-a954cfed100c"> <start x="7876.0" y="3193.0"/> <end x="7792.5806" y="3241.4805"/> </arc> <arc class="consumption" id="cons_9b1e41dd-3064-4c47-9f52-acc89db00114" source="wnc1_s_wnc3_s7_wnc1_wnc3_sa7" target="pr_5978e9d2-4a15-4c1f-8bd9-b41b6c968734_p1"> <start x="7870.0" y="3324.0"/> <end x="7876.5" y="3324.0"/> </arc> <arc class="production" id="prod_18a82bdd-4031-4866-b057-02aed39aeab2" source="pr_5978e9d2-4a15-4c1f-8bd9-b41b6c968734_p2" target="wnc1_s_wnc3_s8_wnc1_wnc3_sa8"> <start x="7906.5" y="3324.0"/> <end x="7913.0" y="3324.0"/> </arc> <arc class="catalysis" id="modif_27519898-0835-4d25-bbbe-d49da8fa50a5" source="wnc1_s_wnc3_s5_wnc1_wnc3_sa5" target="pr_5978e9d2-4a15-4c1f-8bd9-b41b6c968734"> <start x="7756.0" y="3323.5"/> <end x="7891.5" y="3329.0"/> </arc> <arc class="catalysis" id="modif_da5011b3-16c0-4ae0-aa96-47cb7115bb8a" source="wnc1_s_wnc3_s6_wnc1_wnc3_sa6" target="pr_5978e9d2-4a15-4c1f-8bd9-b41b6c968734"> <start x="7753.0" y="3392.0"/> <end x="7891.5" y="3329.0"/> </arc> <arc class="consumption" id="cons_7cc751d9-3889-452d-afc5-4cbcba59186d" source="wnc1_s_wnc3_s9_wnc1_wnc3_sa9" target="pr_312f8c4a-5773-4e88-be7b-230d9e0637b4_p1"> <start x="7793.0" y="3054.0"/> <end x="7793.0" y="3088.0"/> </arc> <arc class="production" id="prod_3d4f55c9-6742-4a74-b3b1-753bbc98d0e5" source="pr_312f8c4a-5773-4e88-be7b-230d9e0637b4_p2" target="wnc1_s_wnc3_s4_wnc1_wnc3_sa4"> <start x="7793.0" y="3118.0"/> <end x="7793.0" y="3152.0"/> </arc> <arc class="consumption" id="cons_8faacf0d-a07b-4722-8d21-6cb5ae0ac989" source="wnc1_s_wnc3_s11_wnc1_wnc3_sa11" target="pr_cda90329-e770-4849-87bc-fb85f9ad9543_p1"> <start x="7877.737" y="3054.0"/> <end x="7876.868" y="3088.5"/> </arc> <arc class="production" id="prod_1dca5353-8856-4822-8651-7846de8267d3" source="pr_cda90329-e770-4849-87bc-fb85f9ad9543_p2" target="wnc1_s_wnc3_s10_wnc1_wnc3_sa10"> <start x="7876.868" y="3118.5"/> <end x="7876.0" y="3153.0"/> </arc> <arc class="consumption" id="cons_a946645e-bea2-41ca-be31-be82eed3f472" source="wnc1_s_wnc3_s29_wnc1_wnc3_sa24" target="pr_0e55e112-191f-49ab-b1a4-54c5448aa8be_p1"> <start x="7697.0" y="3476.0"/> <next x="7697.0" y="3515.6875"/> <end x="7741.5" y="3523.3513"/> </arc> <arc class="consumption" id="cons_69b0d39c-e119-4d64-85bd-8bd35d0e19a4" source="wnc1_s_wnc3_s27_wnc1_wnc3_sa22" target="pr_0e55e112-191f-49ab-b1a4-54c5448aa8be_p1"> <start x="7658.5" y="3553.5"/> <next x="7697.0" y="3515.6875"/> <end x="7741.5" y="3523.3513"/> </arc> <arc class="production" id="prod_fa8d38cc-a865-4fe7-ab2d-36311b8ba889" source="pr_0e55e112-191f-49ab-b1a4-54c5448aa8be_p2" target="wnc1_s_wnc3_s123_wnc1_wnc3_csa1"> <start x="7771.5" y="3523.3513"/> <end x="7812.0" y="3530.5"/> </arc> <arc class="catalysis" id="modif_b50ab286-79cd-485e-9474-a25de1cadb14" source="wnc1_s_wnc3_s60_wnc1_wnc3_sa49" target="pr_0e55e112-191f-49ab-b1a4-54c5448aa8be"> <start x="8261.0" y="3472.0"/> <end x="7757.1387" y="3518.3923"/> </arc> <arc class="catalysis" id="modif_804b8cb3-41d6-4dd2-b4df-a7af577a7a33" source="wnc1_s_wnc3_s64_wnc1_wnc3_sa55" target="pr_0e55e112-191f-49ab-b1a4-54c5448aa8be"> <start x="8565.0" y="3396.0"/> <end x="7760.8203" y="3528.9492"/> </arc> <arc class="catalysis" id="modif_08d727ea-8027-4910-9195-01f83fec0671" source="wnc1_s_wnc3_s90_wnc1_wnc3_sa77" target="pr_0e55e112-191f-49ab-b1a4-54c5448aa8be"> <start x="8740.5" y="3477.0"/> <end x="7755.8613" y="3528.3103"/> </arc> <arc class="consumption" id="addreact_a3e27b8b-e339-4766-ac15-75d6b89c9218" source="wnc1_s_wnc3_s28_wnc1_wnc3_sa23" target="pr_0e55e112-191f-49ab-b1a4-54c5448aa8be_p1"> <start x="7745.437" y="3533.5"/> <end x="7741.5" y="3523.3513"/> </arc> <arc class="consumption" id="addreact_8af0154a-cde1-4606-99ad-c05734235080" source="wnc1_s_wnc3_s30_wnc1_wnc3_sa25" target="pr_0e55e112-191f-49ab-b1a4-54c5448aa8be_p1"> <start x="7680.1943" y="3586.5"/> <end x="7741.5" y="3523.3513"/> </arc> <arc class="consumption" id="cons_55b013e6-5145-4ad8-9c36-1e92a5791980" source="wnc1_s_wnc3_s31_wnc1_wnc3_sa26" target="pr_d29bd802-805a-4972-8c48-086083611b6f_p1"> <start x="7689.5" y="3665.0"/> <next x="7793.75" y="3668.0"/> <end x="7792.875" y="3668.0"/> </arc> <arc class="consumption" id="cons_6c43dcd5-bd41-4bf4-a37c-8ecf0b33cc43" source="wnc1_s_wnc3_s30_wnc1_wnc3_sa25" target="pr_d29bd802-805a-4972-8c48-086083611b6f_p1"> <start x="7660.0" y="3606.5"/> <next x="7793.75" y="3668.0"/> <end x="7792.875" y="3668.0"/> </arc> <arc class="production" id="prod_dbc15fc0-7c3e-4b1b-82d3-dc9b6bfdd538" source="pr_d29bd802-805a-4972-8c48-086083611b6f_p2" target="wnc1_s_wnc3_s128_wnc1_wnc3_csa2"> <start x="7822.875" y="3668.0"/> <end x="7818.0" y="3668.0"/> </arc> <arc class="consumption" id="cons_d2051a44-022a-4499-957e-f7b223774059" source="wnc1_s_wnc3_s30_wnc1_wnc3_sa25" target="pr_02e334e5-d056-4d5c-9c33-bb3adc579762_p1"> <start x="7660.0" y="3606.5"/> <next x="7758.0" y="3773.0"/> <end x="7773.0" y="3781.5713"/> </arc> <arc class="consumption" id="cons_bf7d07ea-58fe-4e4a-8066-3c858e50fdd5" source="wnc1_s_wnc3_s33_wnc1_wnc3_sa28" target="pr_02e334e5-d056-4d5c-9c33-bb3adc579762_p1"> <start x="7641.5" y="3739.0"/> <next x="7758.0" y="3773.0"/> <end x="7773.0" y="3781.5713"/> </arc> <arc class="production" id="prod_1aa56db0-b964-4d34-963e-280fdce28413" source="pr_02e334e5-d056-4d5c-9c33-bb3adc579762_p2" target="wnc1_s_wnc3_s25_wnc1_wnc3_csa3"> <start x="7803.0" y="3781.5713"/> <end x="7814.0" y="3789.0"/> </arc> <arc class="consumption" id="addreact_86b64401-def0-4d0a-af47-cbdf633dadec" source="wnc1_s_wnc3_s32_wnc1_wnc3_sa27" target="pr_02e334e5-d056-4d5c-9c33-bb3adc579762_p1"> <start x="7736.813" y="3794.0"/> <end x="7773.0" y="3781.5713"/> </arc> <arc class="consumption" id="cons_0fed1edc-43bc-4563-877c-3c5973399df4" source="wnc1_s_wnc3_s30_wnc1_wnc3_sa25" target="pr_73601109-7ca4-4c87-abb2-5bb73252d828_p1"> <start x="7660.0" y="3606.5"/> <next x="7749.0" y="3895.0"/> <end x="7769.5" y="3907.4517"/> </arc> <arc class="consumption" id="cons_24870ae3-6a58-43e6-b469-3a61fb02e674" source="wnc1_s_wnc3_s34_wnc1_wnc3_sa29" target="pr_73601109-7ca4-4c87-abb2-5bb73252d828_p1"> <start x="7732.0" y="3895.0"/> <next x="7749.0" y="3895.0"/> <end x="7769.5" y="3907.4517"/> </arc> <arc class="production" id="prod_bdbf1179-ef6b-4ce3-90c9-306858b032ba" source="pr_73601109-7ca4-4c87-abb2-5bb73252d828_p2" target="wnc1_s_wnc3_s36_wnc1_wnc3_csa5"> <start x="7799.5" y="3907.4517"/> <end x="7816.0" y="3918.5"/> </arc> <arc class="consumption" id="addreact_8656c7b4-83c5-4ecd-bbed-57e57ab73f09" source="wnc1_s_wnc3_s35_wnc1_wnc3_sa30" target="pr_73601109-7ca4-4c87-abb2-5bb73252d828_p1"> <start x="7734.116" y="3920.5"/> <end x="7769.5" y="3907.4517"/> </arc> <arc class="consumption" id="cons_e805aa11-26b8-466c-bd0a-4559da35320c" source="wnc1_s_wnc3_s42_wnc1_wnc3_sa36" target="pr_602b5ef0-ce57-492a-8893-408371c88c9d_p1"> <start x="8305.0" y="2860.5"/> <end x="8305.0" y="3009.75"/> </arc> <arc class="production" id="prod_a076583a-e571-4407-9a32-8e3a22793a16" source="pr_602b5ef0-ce57-492a-8893-408371c88c9d_p2" target="wnc1_s_wnc3_s43_wnc1_wnc3_sa37"> <start x="8305.0" y="3039.75"/> <end x="8305.0" y="3189.0"/> </arc> <arc class="consumption" id="cons_a5b66a96-4ea6-471d-a8a8-0394f42bd382" source="wnc1_s_wnc3_s43_wnc1_wnc3_sa37" target="pr_60a02bff-2cc6-4252-beda-10b68281b5dd_p1"> <start x="8305.0" y="3201.5"/> <next x="8248.0" y="3254.0"/> <end x="8202.141" y="3306.5"/> </arc> <arc class="consumption" id="cons_67530298-6eba-4724-8210-23ac00bd0201" source="wnc1_s_wnc3_s40_wnc1_wnc3_sa34" target="pr_60a02bff-2cc6-4252-beda-10b68281b5dd_p1"> <start x="8265.0" y="3254.0"/> <next x="8248.0" y="3254.0"/> <end x="8202.141" y="3306.5"/> </arc> <arc class="production" id="prod_1950c6c5-4172-4a75-80f9-c09e78f13961" source="pr_60a02bff-2cc6-4252-beda-10b68281b5dd_p2" target="wnc1_s_wnc3_s55_wnc1_wnc3_csa6"> <start x="8202.141" y="3336.5"/> <end x="8159.0" y="3385.0"/> </arc> <arc class="catalysis" id="modif_1e371123-3fb7-431e-9dce-1a68f171c64a" source="wnc1_s_wnc3_s52_wnc1_wnc3_csa7" target="pr_60a02bff-2cc6-4252-beda-10b68281b5dd"> <start x="8158.0" y="3207.0"/> <end x="8198.005" y="3318.6902"/> </arc> <arc class="consumption" id="addreact_f7f12d14-4b43-4f90-bdcc-af3c33784ca5" source="wnc1_s_wnc3_s44_wnc1_wnc3_sa38" target="pr_60a02bff-2cc6-4252-beda-10b68281b5dd_p1"> <start x="8268.0" y="3318.0"/> <end x="8202.141" y="3306.5"/> </arc> <arc class="consumption" id="addreact_117a0d03-89e8-4431-81d2-fca17ccfd1bd" source="wnc1_s_wnc3_s30_wnc1_wnc3_sa25" target="pr_60a02bff-2cc6-4252-beda-10b68281b5dd_p1"> <start x="7700.0" y="3606.5"/> <end x="8202.141" y="3306.5"/> </arc> <arc class="consumption" id="addreact_02a16a2c-1af6-43f2-8dd6-fa578eda6ac4" source="wnc1_s_wnc3_s53_wnc1_wnc3_sa44" target="pr_60a02bff-2cc6-4252-beda-10b68281b5dd_p1"> <start x="8260.0" y="3375.0"/> <end x="8202.141" y="3306.5"/> </arc> <arc class="consumption" id="cons_ad545e56-6d47-482e-921d-ab74f4932a7d" source="wnc1_s_wnc3_s59_wnc1_wnc3_sa50" target="pr_703e6834-325f-4464-848f-f2f8e87c8e0f_p1"> <start x="8405.5" y="3472.0"/> <end x="8388.25" y="3472.0"/> </arc> <arc class="production" id="prod_ed6e0326-3be3-4820-88ae-434fcc9f7d94" source="pr_703e6834-325f-4464-848f-f2f8e87c8e0f_p2" target="wnc1_s_wnc3_s60_wnc1_wnc3_sa49"> <start x="8358.25" y="3472.0"/> <end x="8341.0" y="3472.0"/> </arc> <arc class="catalysis" id="modif_3170f457-36b2-474a-97de-dc57727ea17d" source="wnc1_s_wnc3_s61_wnc1_wnc3_sa51" target="pr_703e6834-325f-4464-848f-f2f8e87c8e0f"> <start x="8423.0" y="3397.0"/> <end x="8373.25" y="3467.0"/> </arc> <arc class="consumption" id="cons_7273c471-c460-4a5a-bbe4-94c74524d9ea" source="wnc1_s_wnc3_s11_wnc1_wnc3_sa11" target="pr_d324f7b0-0be0-4283-8112-ecdba422c54b_p1"> <start x="7878.0" y="3054.0"/> <end x="8135.5" y="3205.5"/> </arc> <arc class="production" id="prod_f6d2c9ae-9129-49e5-85d8-6fb4705d0619" source="pr_d324f7b0-0be0-4283-8112-ecdba422c54b_p2" target="wnc1_s_wnc3_s61_wnc1_wnc3_sa51"> <start x="8165.5" y="3205.5"/> <end x="8423.0" y="3357.0"/> </arc> <arc class="consumption" id="cons_adb0d705-52ba-4ad8-8e32-186c1e6c7c22" source="wnc1_s_wnc3_s11_wnc1_wnc3_sa11" target="pr_36f22322-c241-4755-8f2c-73630cf0dd47_p1"> <start x="7878.0" y="3054.0"/> <end x="7768.25" y="3278.75"/> </arc> <arc class="production" id="prod_924db860-0e7b-4504-a58e-b760ee2e0211" source="pr_36f22322-c241-4755-8f2c-73630cf0dd47_p2" target="wnc1_s_wnc3_s27_wnc1_wnc3_sa22"> <start x="7768.25" y="3308.75"/> <end x="7658.5" y="3533.5"/> </arc> <arc class="consumption" id="cons_e6743812-9b1a-4389-85b4-a33f63c3e46b" source="wnc1_s_wnc3_s11_wnc1_wnc3_sa11" target="pr_429e9282-3bed-4844-a7a3-8126727994fe_p1"> <start x="7878.0" y="3054.0"/> <end x="7811.75" y="3278.75"/> </arc> <arc class="production" id="prod_fa12638b-de99-47f1-961d-3b6060ad08b0" source="pr_429e9282-3bed-4844-a7a3-8126727994fe_p2" target="wnc1_s_wnc3_s28_wnc1_wnc3_sa23"> <start x="7811.75" y="3308.75"/> <end x="7745.5" y="3533.5"/> </arc> <arc class="consumption" id="cons_366a8af7-a8f6-49e8-8979-5b2a14d8c7bd" source="wnc1_s_wnc3_s11_wnc1_wnc3_sa11" target="pr_01491629-6461-4c6b-9f8c-3793480ca53c_p1"> <start x="7878.0" y="3054.0"/> <end x="7759.75" y="3371.5"/> </arc> <arc class="production" id="prod_e5bba620-9d8c-4338-9835-9c9bdbf456d2" source="pr_01491629-6461-4c6b-9f8c-3793480ca53c_p2" target="wnc1_s_wnc3_s33_wnc1_wnc3_sa28"> <start x="7759.75" y="3401.5"/> <end x="7641.5" y="3719.0"/> </arc> <arc class="consumption" id="cons_7b5f08a5-3fc6-488a-b15f-0de1ff343f72" source="wnc1_s_wnc3_s5_wnc1_wnc3_sa53" target="pr_7132383d-e6a5-417b-8b4d-c1bc98fed2a7_p1"> <start x="8605.0" y="3219.0"/> <end x="8605.0" y="3232.5"/> </arc> <arc class="production" id="prod_d38f8c42-63a6-4ade-8a48-5e248d03ff1b" source="pr_7132383d-e6a5-417b-8b4d-c1bc98fed2a7_p2" target="wnc1_s_wnc3_s63_wnc1_wnc3_sa54"> <start x="8605.0" y="3262.5"/> <end x="8605.0" y="3276.0"/> </arc> <arc class="catalysis" id="logicarc_effd04dd-8870-4da1-bc1f-a9df3df37ced" source="logicglyph_7e446db4-65de-4f8c-80da-b637e3b5ef57_p2" target="pr_7132383d-e6a5-417b-8b4d-c1bc98fed2a7"> <start x="8695.75" y="3284.75"/> <end x="8610.0" y="3247.5"/> </arc> <arc class="logic arc" id="modif_99830e02-f8e2-4953-8353-5914ea726dd8" source="wnc1_s_wnc3_s65_wnc1_wnc3_sa56" target="logicglyph_7e446db4-65de-4f8c-80da-b637e3b5ef57_p1"> <start x="8750.0" y="3229.0"/> <end x="8735.75" y="3284.75"/> </arc> <arc class="logic arc" id="modif_c10cb36e-976b-4c21-83f6-c336b2bb6da1" source="wnc1_s_wnc3_s66_wnc1_wnc3_sa57" target="logicglyph_7e446db4-65de-4f8c-80da-b637e3b5ef57_p1"> <start x="8750.0" y="3295.5"/> <end x="8735.75" y="3284.75"/> </arc> <arc class="logic arc" id="modif_b1d374de-c347-4d14-948b-547da106210f" source="wnc1_s_wnc3_s67_wnc1_wnc3_sa58" target="logicglyph_7e446db4-65de-4f8c-80da-b637e3b5ef57_p1"> <start x="8750.0" y="3362.0"/> <end x="8735.75" y="3284.75"/> </arc> <arc class="consumption" id="cons_880ab709-b657-43c1-80fe-1a544348a774" source="wnc1_s_wnc3_s63_wnc1_wnc3_sa54" target="pr_8eeb0360-9a17-4127-b91f-de9932e56f57_p1"> <start x="8605.0" y="3316.0"/> <end x="8605.0" y="3331.0"/> </arc> <arc class="production" id="prod_97d4b133-c657-4179-938c-ba43ef2baf24" source="pr_8eeb0360-9a17-4127-b91f-de9932e56f57_p2" target="wnc1_s_wnc3_s64_wnc1_wnc3_sa55"> <start x="8605.0" y="3361.0"/> <end x="8605.0" y="3376.0"/> </arc> <arc class="catalysis" id="logicarc_9cc49bff-1609-4af8-9b39-de2357a5ef54" source="logicglyph_3d6fde74-f4f1-49fa-9e3a-64c96aeba2e2_p2" target="pr_8eeb0360-9a17-4127-b91f-de9932e56f57"> <start x="8697.0" y="3310.0"/> <end x="8610.0" y="3346.0"/> </arc> <arc class="logic arc" id="modif_c125e5f9-5cd8-498c-9729-5a4ec24e0929" source="wnc1_s_wnc3_s65_wnc1_wnc3_sa56" target="logicglyph_3d6fde74-f4f1-49fa-9e3a-64c96aeba2e2_p1"> <start x="8750.0" y="3229.0"/> <end x="8737.0" y="3310.0"/> </arc> <arc class="logic arc" id="modif_0f55815d-3325-4c1d-b683-4dc6c3e69043" source="wnc1_s_wnc3_s66_wnc1_wnc3_sa57" target="logicglyph_3d6fde74-f4f1-49fa-9e3a-64c96aeba2e2_p1"> <start x="8750.0" y="3295.5"/> <end x="8737.0" y="3310.0"/> </arc> <arc class="logic arc" id="modif_b96d06b6-c146-479c-86b5-f116395ebaec" source="wnc1_s_wnc3_s67_wnc1_wnc3_sa58" target="logicglyph_3d6fde74-f4f1-49fa-9e3a-64c96aeba2e2_p1"> <start x="8750.0" y="3362.0"/> <end x="8737.0" y="3310.0"/> </arc> <arc class="consumption" id="cons_1e7158cf-5959-4dea-b335-64a1b7a3b732" source="wnc1_s_wnc3_s6_wnc1_wnc3_sa59" target="pr_1ad15184-2144-4e43-bc49-38d02034c655_p1"> <start x="8974.5" y="3219.0"/> <end x="8974.5" y="3232.5"/> </arc> <arc class="production" id="prod_2d53d6fc-3f37-4e55-a070-e5baa6ba6246" source="pr_1ad15184-2144-4e43-bc49-38d02034c655_p2" target="wnc1_s_wnc3_s69_wnc1_wnc3_sa60"> <start x="8974.5" y="3262.5"/> <end x="8974.5" y="3276.0"/> </arc> <arc class="catalysis" id="logicarc_512dfd28-85a8-4c70-b51b-ed2758c74d01" source="logicglyph_708489ac-2f51-44b7-b610-84fe512ed114_p2" target="pr_1ad15184-2144-4e43-bc49-38d02034c655"> <start x="8882.5" y="3283.5"/> <end x="8969.5" y="3247.5"/> </arc> <arc class="logic arc" id="modif_9ed43702-0bb0-414f-be8a-93cc4c1c6be7" source="wnc1_s_wnc3_s65_wnc1_wnc3_sa56" target="logicglyph_708489ac-2f51-44b7-b610-84fe512ed114_p1"> <start x="8830.0" y="3229.0"/> <end x="8842.5" y="3283.5"/> </arc> <arc class="logic arc" id="modif_bbea6ba9-079a-4292-a935-dc77ae0c06dc" source="wnc1_s_wnc3_s66_wnc1_wnc3_sa57" target="logicglyph_708489ac-2f51-44b7-b610-84fe512ed114_p1"> <start x="8830.0" y="3295.5"/> <end x="8842.5" y="3283.5"/> </arc> <arc class="logic arc" id="modif_86c53cff-932a-46bd-aa09-c26491ae3c59" source="wnc1_s_wnc3_s67_wnc1_wnc3_sa58" target="logicglyph_708489ac-2f51-44b7-b610-84fe512ed114_p1"> <start x="8830.0" y="3362.0"/> <end x="8842.5" y="3283.5"/> </arc> <arc class="consumption" id="cons_03775f1c-41e3-4943-8b04-f8dbca181031" source="wnc1_s_wnc3_s69_wnc1_wnc3_sa60" target="pr_855643d9-5a01-4452-ad5e-c4be2e5ac1be_p1"> <start x="9014.5" y="3296.0"/> <next x="9195.75" y="3423.0"/> <end x="9197.261" y="3430.25"/> </arc> <arc class="consumption" id="cons_ce2ba782-693a-4cd6-a64f-b5c7f1df9ac4" source="wnc1_s_wnc3_s75_wnc1_wnc3_csa9" target="pr_855643d9-5a01-4452-ad5e-c4be2e5ac1be_p1"> <start x="9194.5" y="3389.0"/> <next x="9195.75" y="3423.0"/> <end x="9197.261" y="3430.25"/> </arc> <arc class="production" id="prod_0b38a0b3-85a2-4840-8932-8ec98b588429" source="pr_855643d9-5a01-4452-ad5e-c4be2e5ac1be_p2" target="wnc1_s_wnc3_s83_wnc1_wnc3_csa10"> <start x="9197.261" y="3460.25"/> <end x="9198.5" y="3463.5"/> </arc> <arc class="consumption" id="cons_0e644c19-8a22-485a-8044-15b219ef4933" source="wnc1_s_wnc3_s85_wnc1_wnc3_sa74" target="pr_4db67226-4636-4e45-b365-d268357c7bff_p1"> <start x="8161.0" y="3581.0"/> <end x="8172.5" y="3581.0"/> </arc> <arc class="production" id="prod_ffcc6e86-c714-4748-ba63-eb21e757f0f7" source="pr_4db67226-4636-4e45-b365-d268357c7bff_p2" target="wnc1_s_wnc3_s86_wnc1_wnc3_sa75"> <start x="8202.5" y="3581.0"/> <end x="8214.0" y="3581.0"/> </arc> <arc class="inhibition" id="modif_f10393c0-509d-46e7-bad2-debc5e751a60" source="wnc1_s_wnc3_s83_wnc1_wnc3_csa10" target="pr_4db67226-4636-4e45-b365-d268357c7bff"> <start x="9106.5" y="3565.5"/> <end x="8182.5" y="3576.0"/> </arc> <arc class="consumption" id="cons_3c7a061d-a04a-414d-8309-56336c2b4644" source="wnc1_s_wnc3_s60_wnc1_wnc3_sa49" target="pr_e10f09c2-92cc-46a4-a487-2c24d2269159_p1"> <start x="8261.0" y="3472.0"/> <end x="7995.5" y="3539.25"/> </arc> <arc class="production" id="prod_d1819971-65b1-4ee8-a13e-f33700b49185" source="pr_e10f09c2-92cc-46a4-a487-2c24d2269159_p2" target="wnc1_s_wnc3_s30_wnc1_wnc3_sa25"> <start x="7965.5" y="3539.25"/> <end x="7700.0" y="3606.5"/> </arc> <arc class="consumption" id="cons_d9cdc86f-e9a7-4a6a-890e-eb4fcd7bd803" source="wnc1_s_wnc3_s64_wnc1_wnc3_sa55" target="pr_e2aa6502-ac13-42cd-a66a-7dd496672c84_p1"> <start x="8605.0" y="3416.0"/> <end x="8167.5" y="3511.25"/> </arc> <arc class="production" id="prod_bfbffa18-06d1-46b4-b2ee-5321348c3f4c" source="pr_e2aa6502-ac13-42cd-a66a-7dd496672c84_p2" target="wnc1_s_wnc3_s30_wnc1_wnc3_sa25"> <start x="8137.5" y="3511.25"/> <end x="7700.0" y="3606.5"/> </arc> <arc class="consumption" id="cons_6384fe21-4559-48a6-8b07-0256d4a33fff" source="wnc1_s_wnc3_s5_wnc1_wnc3_sa53" target="pr_1114265a-e92f-4288-9eaf-44562657d5f2_p1"> <start x="8605.0" y="3219.0"/> <end x="8692.75" y="3323.0"/> </arc> <arc class="production" id="prod_88f0e1a2-d37b-45c0-9a23-be9e1a17eb7a" source="pr_1114265a-e92f-4288-9eaf-44562657d5f2_p2" target="wnc1_s_wnc3_s90_wnc1_wnc3_sa77"> <start x="8692.75" y="3353.0"/> <end x="8780.5" y="3457.0"/> </arc> <arc class="catalysis" id="modif_13909a08-763a-4baa-ad50-e48e1e461aba" source="wnc1_s_wnc3_s88_wnc1_wnc3_sa76" target="pr_1114265a-e92f-4288-9eaf-44562657d5f2"> <start x="8643.0" y="3478.0"/> <end x="8688.726" y="3340.9675"/> </arc> <arc class="consumption" id="cons_b0a89d57-db05-427d-b093-1735f3665f1d" source="wnc1_s_wnc3_s90_wnc1_wnc3_sa77" target="pr_2b1531d3-b0f6-4c93-a453-f84dba4560e6_p1"> <start x="8740.5" y="3477.0"/> <end x="8235.25" y="3541.75"/> </arc> <arc class="production" id="prod_03d13d9c-e9e0-4f4d-8be6-6d693c6aa5fc" source="pr_2b1531d3-b0f6-4c93-a453-f84dba4560e6_p2" target="wnc1_s_wnc3_s30_wnc1_wnc3_sa25"> <start x="8205.25" y="3541.75"/> <end x="7700.0" y="3606.5"/> </arc> <arc class="consumption" id="cons_892cd208-b6f9-48bf-90ae-998ab03964dc" source="wnc1_s_wnc3_s95_wnc1_wnc3_sa81" target="pr_d476b01d-f760-4b65-8eec-9f35c3d0094e_p1"> <start x="8158.0" y="3629.0"/> <end x="8167.0" y="3629.0"/> </arc> <arc class="production" id="prod_6a6d1bee-c75a-453a-bfdf-0a6d0576e4cc" source="pr_d476b01d-f760-4b65-8eec-9f35c3d0094e_p2" target="wnc1_s_wnc3_s96_wnc1_wnc3_sa82"> <start x="8197.0" y="3629.0"/> <end x="8206.0" y="3629.0"/> </arc> <arc class="inhibition" id="modif_e6986993-1a32-44ca-9562-83cfb6af4dba" source="wnc1_s_wnc3_s92_wnc1_wnc3_csa11" target="pr_d476b01d-f760-4b65-8eec-9f35c3d0094e"> <start x="8927.0" y="3564.5"/> <end x="8182.0" y="3624.0"/> </arc> <arc class="consumption" id="cons_406f7445-7698-4f2b-ae30-a6bc08438afa" source="wnc1_s_wnc3_s5_wnc1_wnc3_sa53" target="pr_d869e93f-dce4-4a6c-88e3-e96267f0bb34_p1"> <start x="8605.0" y="3219.0"/> <next x="8973.0" y="3479.0"/> <end x="8975.119" y="3475.5"/> </arc> <arc class="consumption" id="cons_b5b30a82-2186-46e2-b832-36f5a8471c76" source="wnc1_s_wnc3_s91_wnc1_wnc3_sa78" target="pr_d869e93f-dce4-4a6c-88e3-e96267f0bb34_p1"> <start x="8966.0" y="3461.0"/> <next x="8973.0" y="3479.0"/> <end x="8975.119" y="3475.5"/> </arc> <arc class="production" id="prod_63425d0a-aa74-4632-abdb-574f0bbf9fd3" source="pr_d869e93f-dce4-4a6c-88e3-e96267f0bb34_p2" target="wnc1_s_wnc3_s92_wnc1_wnc3_csa11"> <start x="8975.119" y="3505.5"/> <end x="8976.5" y="3498.0"/> </arc> <arc class="consumption" id="cons_ffbac9f4-0bbc-4537-8abe-2003c9526ed7" source="wnc1_s_wnc3_s97_wnc1_wnc3_sa83" target="pr_f83b20be-aaaa-4ac3-a8b6-236b28d8b66d_p1"> <start x="8158.0" y="3665.0"/> <end x="8167.0" y="3665.0"/> </arc> <arc class="production" id="prod_7c781c51-d4e9-4cf1-800b-82ecade20941" source="pr_f83b20be-aaaa-4ac3-a8b6-236b28d8b66d_p2" target="wnc1_s_wnc3_s98_wnc1_wnc3_sa84"> <start x="8197.0" y="3665.0"/> <end x="8206.0" y="3665.0"/> </arc> <arc class="catalysis" id="modif_634a776b-2d31-46e8-8ae1-0acdc8e2f587" source="wnc1_s_wnc3_s123_wnc1_wnc3_csa1" target="pr_f83b20be-aaaa-4ac3-a8b6-236b28d8b66d"> <start x="7999.0" y="3530.5"/> <end x="8182.0" y="3660.0"/> </arc> <arc class="catalysis" id="modif_80148447-5e3d-48d7-aee9-145108f91359" source="wnc1_s_wnc3_s123_wnc1_wnc3_csa16" target="pr_f83b20be-aaaa-4ac3-a8b6-236b28d8b66d"> <start x="8573.0" y="3590.0"/> <end x="8187.0" y="3660.0"/> </arc> <arc class="consumption" id="cons_24ea20ab-2dc9-4b5d-a643-5d372a54396c" source="wnc1_s_wnc3_s130_wnc1_wnc3_csa12" target="pr_d0c404b0-1464-44f4-925f-61111d090230_p1"> <start x="8134.0" y="3868.0"/> <end x="8133.577" y="3864.0"/> </arc> <arc class="production" id="prod_bb92371c-9a01-4520-bae1-f99be20eedd2" source="pr_d0c404b0-1464-44f4-925f-61111d090230_p2" target="wnc1_s_wnc3_s131_wnc1_wnc3_csa13"> <start x="8133.577" y="3894.0"/> <next x="8133.154" y="3890.0"/> <end x="8134.0" y="3916.5"/> </arc> <arc class="production" id="prod_34233f05-39cc-4d39-99a0-9a683f0bc2af" source="pr_d0c404b0-1464-44f4-925f-61111d090230_p2" target="wnc1_s_wnc3_s30_wnc1_wnc3_sa25"> <start x="8133.577" y="3894.0"/> <next x="8133.154" y="3890.0"/> <end x="7700.0" y="3606.5"/> </arc> <arc class="consumption" id="cons_7e0eb211-b7b6-4464-99b5-5c89f87019c1" source="wnc1_s_wnc3_s130_wnc1_wnc3_csa12" target="pr_23a3e8c5-6b1a-45fb-9348-6c335b9eb8c4_p1"> <start x="8184.0" y="3783.5"/> <next x="8257.0" y="3783.5"/> <end x="8266.5" y="3783.7722"/> </arc> <arc class="consumption" id="cons_803c9b24-f8eb-4849-bd10-2932ed651738" source="wnc1_s_wnc3_s108_wnc1_wnc3_sa91" target="pr_23a3e8c5-6b1a-45fb-9348-6c335b9eb8c4_p1"> <start x="8257.0" y="3911.0"/> <next x="8257.0" y="3783.5"/> <end x="8266.5" y="3783.7722"/> </arc> <arc class="production" id="prod_44516579-63cd-43ac-a33d-c8f7bf921678" source="pr_23a3e8c5-6b1a-45fb-9348-6c335b9eb8c4_p2" target="wnc1_s_wnc3_s133_wnc1_wnc3_csa14"> <start x="8296.5" y="3783.7722"/> <end x="8302.0" y="3784.0"/> </arc> <arc class="consumption" id="addreact_688688e7-f1ce-4609-84d2-7397f028056b" source="wnc1_s_wnc3_s109_wnc1_wnc3_sa92" target="pr_23a3e8c5-6b1a-45fb-9348-6c335b9eb8c4_p1"> <start x="8351.0" y="3911.0"/> <end x="8266.5" y="3783.7722"/> </arc> <arc class="consumption" id="cons_922f22ed-9b5a-4218-a348-2d77dc65cb78" source="wnc1_s_wnc3_s133_wnc1_wnc3_csa14" target="pr_bcf0a047-7127-43e7-a27f-b5917163cbee_p1"> <start x="8486.0" y="3784.0"/> <end x="8515.0" y="3784.0"/> </arc> <arc class="production" id="prod_524f141f-f6fd-4926-911f-af9331f7d689" source="pr_bcf0a047-7127-43e7-a27f-b5917163cbee_p2" target="wnc1_s_wnc3_s132_wnc1_wnc3_csa15"> <start x="8545.0" y="3784.0"/> <end x="8574.0" y="3784.0"/> </arc> <arc class="consumption" id="cons_8fee54e5-a06a-42b4-93f6-421d065b2070" source="wnc1_s_wnc3_s132_wnc1_wnc3_csa15" target="pr_3c696801-c935-4a67-856d-208091d9afb2_p1"> <start x="8666.0" y="3704.5"/> <end x="8666.25" y="3697.0"/> </arc> <arc class="production" id="prod_6b975cfb-b75a-43df-afac-9968481905d2" source="pr_3c696801-c935-4a67-856d-208091d9afb2_p2" target="wnc1_s_wnc3_s123_wnc1_wnc3_csa16"> <start x="8666.25" y="3667.0"/> <end x="8666.5" y="3659.5"/> </arc> <arc class="catalysis" id="modif_5ad8c5a7-8960-4cf6-8de2-cef33a866327" source="wnc1_s_wnc3_s132_wnc1_wnc3_csa15" target="pr_3c696801-c935-4a67-856d-208091d9afb2"> <start x="8758.0" y="3784.0"/> <next x="8777.001" y="3783.999"/> <next x="8776.995" y="3682.0498"/> <end x="8671.25" y="3682.0557"/> </arc> <arc class="consumption" id="addreact_852c44a3-b0bb-4094-95c2-82aa0a3cc43f" source="wnc1_s_wnc3_s29_wnc1_wnc3_sa24" target="pr_3c696801-c935-4a67-856d-208091d9afb2_p1"> <start x="7697.0" y="3487.0"/> <end x="8666.25" y="3697.0"/> </arc> <arc class="consumption" id="addreact_4a325b11-2ae6-4c80-a2ef-96e204917538" source="wnc1_s_wnc3_s27_wnc1_wnc3_sa22" target="pr_3c696801-c935-4a67-856d-208091d9afb2_p1"> <start x="7658.5" y="3573.5"/> <end x="8666.25" y="3697.0"/> </arc> <arc class="consumption" id="addreact_35c4f826-8af1-4a19-9cef-db41c72b9cd6" source="wnc1_s_wnc3_s28_wnc1_wnc3_sa23" target="pr_3c696801-c935-4a67-856d-208091d9afb2_p1"> <start x="7745.5" y="3573.5"/> <end x="8666.25" y="3697.0"/> </arc> <arc class="production" id="addprod_1c26eeef-e5cb-42c7-98a5-ac3e3e5a078b" source="pr_3c696801-c935-4a67-856d-208091d9afb2_p2" target="wnc1_s_wnc3_s131_wnc1_wnc3_csa13"> <start x="8666.25" y="3667.0"/> <end x="8182.0" y="3973.0"/> </arc> <arc class="production" id="addprod_812c8004-5589-4c5b-bca3-28edc9c2ef42" source="pr_3c696801-c935-4a67-856d-208091d9afb2_p2" target="wnc1_s_wnc3_s108_wnc1_wnc3_sa91"> <start x="8666.25" y="3667.0"/> <end x="8257.0" y="3911.0"/> </arc> <arc class="production" id="addprod_5e118fbc-5c67-4714-bd84-7b99fce12be0" source="pr_3c696801-c935-4a67-856d-208091d9afb2_p2" target="wnc1_s_wnc3_s109_wnc1_wnc3_sa92"> <start x="8666.25" y="3667.0"/> <end x="8351.0" y="3911.0"/> </arc> <arc class="consumption" id="cons_64d5c2ca-bd72-4a95-9ae0-11fff8e1c94c" source="wnc1_s_wnc3_s11_wnc1_wnc3_sa11" target="pr_285a3894-614d-42d0-aab0-d0fdf09e611f_p1"> <start x="7878.0" y="3054.0"/> <end x="8063.178" y="3467.5"/> </arc> <arc class="production" id="prod_d0877235-1d57-49a0-af1a-4c7369a8f5fe" source="pr_285a3894-614d-42d0-aab0-d0fdf09e611f_p2" target="wnc1_s_wnc3_s108_wnc1_wnc3_sa91"> <start x="8063.178" y="3497.5"/> <end x="8248.356" y="3911.0"/> </arc> <arc class="consumption" id="cons_aac74374-6665-45be-a3f4-010c174362f0" source="wnc1_s_wnc3_s11_wnc1_wnc3_sa11" target="pr_cb31c810-775c-4f3d-9534-2cfb852f593d_p1"> <start x="7878.0" y="3054.0"/> <end x="8109.1064" y="3467.5"/> </arc> <arc class="production" id="prod_f582a45a-321d-45db-9ad7-cd49beea7220" source="pr_cb31c810-775c-4f3d-9534-2cfb852f593d_p2" target="wnc1_s_wnc3_s109_wnc1_wnc3_sa92"> <start x="8109.1064" y="3497.5"/> <end x="8340.213" y="3911.0"/> </arc> <arc class="consumption" id="cons_2ae92fa4-33d6-42dd-8fbf-18cef2d191a4" source="wnc1_s_wnc4_s3_wnc1_wnc4_sa3" target="pr_d6b3244d-5126-4edf-9b3b-6fa3d18b2fa5_p1"> <start x="10296.0" y="3005.0"/> <end x="10307.0" y="3005.0"/> </arc> <arc class="production" id="prod_471b0b13-6441-4154-a82f-93abd8eed0e8" source="pr_d6b3244d-5126-4edf-9b3b-6fa3d18b2fa5_p2" target="wnc1_s_wnc4_s5_wnc1_wnc4_sa4"> <start x="10337.0" y="3005.0"/> <end x="10348.0" y="3005.0"/> </arc> <arc class="catalysis" id="modif_1359cb6d-38ff-4415-affa-8c14d91478d3" source="wnc1_s_wnc4_s11_wnc1_wnc4_sa8" target="pr_d6b3244d-5126-4edf-9b3b-6fa3d18b2fa5"> <start x="10212.0" y="3147.0"/> <end x="10322.0" y="3010.0"/> </arc> <arc class="consumption" id="cons_702ed1ce-1e92-4f6f-b013-119d8b61e93d" source="wnc1_s_wnc4_s2_wnc1_wnc4_sa2" target="pr_d76b06bb-2184-485d-ba74-24931ba06f1e_p1"> <start x="9880.0" y="2963.0"/> <next x="9933.0" y="3003.0"/> <end x="9942.5" y="3003.0"/> </arc> <arc class="consumption" id="cons_ddd57072-06eb-4a2d-b4a9-eb8ac4b88920" source="wnc1_s_wnc4_s1_wnc1_wnc4_sa5" target="pr_d76b06bb-2184-485d-ba74-24931ba06f1e_p1"> <start x="9933.0" y="3086.0"/> <next x="9933.0" y="3003.0"/> <end x="9942.5" y="3003.0"/> </arc> <arc class="production" id="prod_9819703e-09b4-4c49-8365-f330e5c1da27" source="pr_d76b06bb-2184-485d-ba74-24931ba06f1e_p2" target="wnc1_s_wnc4_s8_wnc1_wnc4_csa1"> <start x="9972.5" y="3003.0"/> <end x="9978.0" y="3003.0"/> </arc> <arc class="consumption" id="cons_bc9ec9b9-1b32-4d11-9246-44e2886a7880" source="wnc1_s_wnc4_s8_wnc1_wnc4_csa1" target="pr_8728fa11-4ed3-4232-8dbd-91d4023cfcd5_p1"> <start x="10078.0" y="3063.0"/> <end x="10115.961" y="3090.0"/> </arc> <arc class="production" id="prod_951e2833-dbf0-4556-aed6-195ca3bff912" source="pr_8728fa11-4ed3-4232-8dbd-91d4023cfcd5_p2" target="wnc1_s_wnc4_s11_wnc1_wnc4_sa8"> <start x="10115.961" y="3120.0"/> <end x="10153.923" y="3147.0"/> </arc> <arc class="catalysis" id="modif_70ab7622-c2a9-405e-bd25-d27a8fefce3c" source="wnc1_s_wnc4_s12_wnc1_wnc4_sa9" target="pr_8728fa11-4ed3-4232-8dbd-91d4023cfcd5"> <start x="10149.578" y="3084.0"/> <end x="10119.67" y="3101.6472"/> </arc> <arc class="consumption" id="cons_8b20ed83-894d-4f31-bace-279432e5cce0" source="wnc1_s_wnc4_s183_wnc1_wnc4_csa2" target="pr_55011c9c-aac9-479b-930a-5770b543cdfb_p1"> <start x="9920.5" y="3315.0"/> <end x="9920.5" y="3333.25"/> </arc> <arc class="production" id="prod_6f50ca77-67df-4a09-9477-8e82bbad59fe" source="pr_55011c9c-aac9-479b-930a-5770b543cdfb_p2" target="wnc1_s_wnc4_s184_wnc1_wnc4_csa3"> <start x="9920.5" y="3363.25"/> <end x="9920.5" y="3381.5"/> </arc> <arc class="catalysis" id="modif_b1cba72d-b9ab-4fe6-8e69-4b33effcb105" source="wnc1_s_wnc4_s8_wnc1_wnc4_csa1" target="pr_55011c9c-aac9-479b-930a-5770b543cdfb"> <start x="10028.0" y="3063.0"/> <end x="9925.5" y="3348.25"/> </arc> <arc class="consumption" id="cons_bea2ade5-5a5d-4082-a79a-4a3378f07481" source="wnc1_s_wnc4_s184_wnc1_wnc4_csa3" target="pr_d00358e7-6b90-4178-9117-48a55f3a9060_p1"> <start x="9920.5" y="3540.5"/> <end x="9920.5" y="3544.5"/> </arc> <arc class="production" id="prod_8ec69143-3544-43ea-b65e-6c9bcae6ad62" source="pr_d00358e7-6b90-4178-9117-48a55f3a9060_p2" target="wnc1_s_wnc4_s42_wnc1_wnc4_sa24"> <start x="9920.5" y="3574.5"/> <next x="9920.5" y="3578.5"/> <end x="10124.0" y="3582.5"/> </arc> <arc class="production" id="prod_31adb0d2-730b-452d-b3b9-1fbdd59f64ad" source="pr_d00358e7-6b90-4178-9117-48a55f3a9060_p2" target="wnc1_s_wnc4_s185_wnc1_wnc4_csa4"> <start x="9920.5" y="3574.5"/> <next x="9920.5" y="3578.5"/> <end x="9920.5" y="3629.5"/> </arc> <arc class="consumption" id="cons_c7493529-5e64-4614-b210-bf1c39935916" source="wnc1_s_wnc4_s5_wnc1_wnc4_sa4" target="pr_654fb044-2326-4371-bc31-0320c665af86_p1"> <start x="10428.0" y="3005.0"/> <end x="10453.5" y="3004.6653"/> </arc> <arc class="production" id="prod_861137f0-d661-4dd7-9e99-fe2d68653deb" source="pr_654fb044-2326-4371-bc31-0320c665af86_p2" target="wnc1_s_wnc4_s43_wnc1_wnc4_sa25"> <start x="10483.5" y="3004.6653"/> <end x="10509.0" y="3004.3306"/> </arc> <arc class="consumption" id="cons_78781e0b-252d-4359-9206-97417456b59a" source="wnc1_s_wnc4_s42_wnc1_wnc4_sa24" target="pr_87673f18-4066-4d87-8074-d49341f73746_p1"> <start x="10204.0" y="3582.5"/> <end x="10221.0" y="3582.3462"/> </arc> <arc class="production" id="prod_932841fc-2b4d-4994-9a25-94889235e6e1" source="pr_87673f18-4066-4d87-8074-d49341f73746_p2" target="wnc1_s_wnc4_s44_wnc1_wnc4_sa26"> <start x="10251.0" y="3582.3462"/> <end x="10268.0" y="3582.1924"/> </arc> <arc class="consumption" id="cons_7daab7f0-be2f-406f-a71f-5821387c3920" source="wnc1_s_wnc4_s45_wnc1_wnc4_sa27" target="pr_63ae3207-0b27-479b-bfde-0cee90bad359_p1"> <start x="10819.0" y="4007.0"/> <next x="10835.0" y="4065.0"/> <end x="10859.5" y="4065.5266"/> </arc> <arc class="consumption" id="cons_9d78f041-b148-4b7f-9e21-7def93133ba1" source="wnc1_s_wnc4_s46_wnc1_wnc4_sa28" target="pr_63ae3207-0b27-479b-bfde-0cee90bad359_p1"> <start x="10819.0" y="4065.0"/> <next x="10835.0" y="4065.0"/> <end x="10859.5" y="4065.5266"/> </arc> <arc class="production" id="prod_4566d4b9-cbfe-4a1a-b97b-7df35c7439a2" source="pr_63ae3207-0b27-479b-bfde-0cee90bad359_p2" target="wnc1_s_wnc4_s48_wnc1_wnc4_csa5"> <start x="10889.5" y="4065.5266"/> <end x="10910.0" y="4066.0"/> </arc> <arc class="consumption" id="addreact_32f19791-7ec6-4b4b-a653-5fd2f4fcd8d4" source="wnc1_s_wnc4_s47_wnc1_wnc4_sa29" target="pr_63ae3207-0b27-479b-bfde-0cee90bad359_p1"> <start x="10819.0" y="4129.0"/> <end x="10859.5" y="4065.5266"/> </arc> <arc class="consumption" id="cons_020801e5-2352-4e01-be4f-ce2f502e8a76" source="wnc1_s_wnc4_s48_wnc1_wnc4_csa5" target="pr_201ada39-bbdd-48af-8164-b44de56fb55f_p1"> <start x="11009.0" y="4066.0"/> <end x="11034.5" y="4065.5"/> </arc> <arc class="production" id="prod_0d6ee8dc-8546-4be3-8ef2-eb3113fc2a0b" source="pr_201ada39-bbdd-48af-8164-b44de56fb55f_p2" target="wnc1_s_wnc4_s52_wnc1_wnc4_csa6"> <start x="11064.5" y="4065.5"/> <end x="11090.0" y="4065.0"/> </arc> <arc class="stimulation" id="direct_2102dadd-f4a2-4bdd-8047-c5d03b4aac3d" source="wnc1_s_wnc4_s52_wnc1_wnc4_csa6" target="wnc1_s_wnc4_s56_wnc1_wnc4_sa36"> <start x="11189.0" y="4065.0"/> <end x="11266.0" y="4038.6753"/> </arc> <arc class="stimulation" id="direct_7d4ac760-d67f-4949-be25-c85add8657c7" source="wnc1_s_wnc4_s52_wnc1_wnc4_csa6" target="wnc1_s_wnc4_s57_wnc1_wnc4_sa37"> <start x="11189.0" y="4065.0"/> <end x="11268.0" y="4085.5798"/> </arc> <arc class="stimulation" id="direct_40e0b392-9b5b-4ede-aa77-ed3f2e6f1d60" source="wnc1_s_wnc4_s58_wnc1_wnc4_sa38" target="wnc1_s_wnc4_s59_wnc1_wnc4_sa39"> <start x="10779.281" y="4227.0"/> <end x="10779.789" y="4263.0"/> </arc> <arc class="consumption" id="cons_388bc461-1bf7-4c9f-b74e-262c012553ad" source="wnc1_s_wnc4_s58_wnc1_wnc4_sa38" target="pr_cc8c6a5d-75e5-4fd6-93f6-6775aa75bf9c_p1"> <start x="10819.0" y="4207.0"/> <next x="10938.0" y="4232.0"/> <end x="10978.5" y="4230.444"/> </arc> <arc class="consumption" id="cons_28259540-81d7-4eb4-857d-5de43089f184" source="wnc1_s_wnc4_s60_wnc1_wnc4_sa41" target="pr_cc8c6a5d-75e5-4fd6-93f6-6775aa75bf9c_p1"> <start x="10921.0" y="4232.0"/> <next x="10938.0" y="4232.0"/> <end x="10978.5" y="4230.444"/> </arc> <arc class="production" id="prod_c294b36d-b97c-464f-a558-78311b87277e" source="pr_cc8c6a5d-75e5-4fd6-93f6-6775aa75bf9c_p2" target="wnc1_s_wnc4_s189_wnc1_wnc4_csa8"> <start x="11008.5" y="4230.444"/> <end x="11045.0" y="4229.0"/> </arc> <arc class="consumption" id="addreact_43b5014e-23b2-4d0d-84f4-68876f43adfc" source="wnc1_s_wnc4_s61_wnc1_wnc4_sa73" target="pr_cc8c6a5d-75e5-4fd6-93f6-6775aa75bf9c_p1"> <start x="10978.0" y="4667.0"/> <end x="10978.5" y="4230.444"/> </arc> <arc class="consumption" id="addreact_e7193c4d-a978-49ee-8bd8-f46e61302812" source="wnc1_s_wnc4_s62_wnc1_wnc4_sa43" target="pr_cc8c6a5d-75e5-4fd6-93f6-6775aa75bf9c_p1"> <start x="10920.0" y="4283.0"/> <end x="10978.5" y="4230.444"/> </arc> <arc class="consumption" id="cons_59d1725c-fc1f-4f8c-8ed1-28fe15db4b5c" source="wnc1_s_wnc4_s189_wnc1_wnc4_csa8" target="pr_7f3c58cd-1427-44e3-98b1-618df10c1de5_p1"> <start x="11175.5" y="4292.5"/> <end x="11175.5" y="4331.5"/> </arc> <arc class="production" id="prod_8f3aed91-862f-4178-b93d-b4f52c258f3e" source="pr_7f3c58cd-1427-44e3-98b1-618df10c1de5_p2" target="wnc1_s_wnc4_s186_wnc1_wnc4_csa9"> <start x="11175.5" y="4361.5"/> <end x="11175.5" y="4400.5"/> </arc> <arc class="consumption" id="cons_0047a6a6-59f2-4775-beaf-9e2672c54b69" source="wnc1_s_wnc4_s186_wnc1_wnc4_csa9" target="pr_c475cc37-af32-46b8-8c3f-9dfe2d51f61f_p1"> <start x="11042.0" y="4462.0"/> <end x="11028.0" y="4462.0"/> </arc> <arc class="production" id="prod_6c293bd2-8650-485b-8ea2-0589f6304b48" source="pr_c475cc37-af32-46b8-8c3f-9dfe2d51f61f_p2" target="wnc1_s_wnc4_s187_wnc1_wnc4_csa10"> <start x="10998.0" y="4462.0"/> <end x="10984.0" y="4462.0"/> </arc> <arc class="catalysis" id="modif_3c60f9cf-db90-40be-8ee9-93fec6970ab6" source="wnc1_s_wnc4_s188_wnc1_wnc4_csa7" target="pr_c475cc37-af32-46b8-8c3f-9dfe2d51f61f"> <start x="10988.0" y="4346.5"/> <end x="11013.0" y="4457.0"/> </arc> <arc class="consumption" id="cons_8f7ca588-39ff-4e61-874d-5bc4d68ce32b" source="wnc1_s_wnc4_s187_wnc1_wnc4_csa10" target="pr_a9e5c390-07fe-4d0c-bedc-5e54e3d566f4_p1"> <start x="10851.0" y="4521.5"/> <end x="10836.5" y="4532.2695"/> </arc> <arc class="production" id="prod_8f4d661e-f047-4fc1-8ff7-0b6346112d64" source="pr_a9e5c390-07fe-4d0c-bedc-5e54e3d566f4_p2" target="wnc1_s_wnc4_s95_wnc1_wnc4_sa68"> <start x="10806.5" y="4532.2695"/> <next x="10792.0" y="4543.0396"/> <end x="10762.25" y="4569.0"/> </arc> <arc class="production" id="prod_0ac3adca-ff2c-478a-b47c-2a4e56d12a07" source="pr_a9e5c390-07fe-4d0c-bedc-5e54e3d566f4_p2" target="wnc1_s_wnc4_s60_wnc1_wnc4_sa41"> <start x="10806.5" y="4532.2695"/> <next x="10792.0" y="4543.0396"/> <end x="10881.0" y="4252.0"/> </arc> <arc class="production" id="addprod_b046f325-de8d-4fbf-9ed6-145af257ffb2" source="pr_a9e5c390-07fe-4d0c-bedc-5e54e3d566f4_p2" target="wnc1_s_wnc4_s62_wnc1_wnc4_sa43"> <start x="10806.5" y="4532.2695"/> <end x="10900.0" y="4303.0"/> </arc> <arc class="production" id="addprod_746e3bbd-9d89-4377-a53d-2413a87b6f53" source="pr_a9e5c390-07fe-4d0c-bedc-5e54e3d566f4_p2" target="wnc1_s_wnc4_s61_wnc1_wnc4_sa73"> <start x="10806.5" y="4532.2695"/> <end x="10978.0" y="4667.0"/> </arc> <arc class="consumption" id="cons_28a5008a-618d-41e4-b566-68897224783f" source="wnc1_s_wnc4_s95_wnc1_wnc4_sa68" target="pr_cc9e9a00-3053-4901-971c-d32a1b377fc1_p1"> <start x="10802.25" y="4589.0"/> <end x="10831.25" y="4589.0"/> </arc> <arc class="production" id="prod_f45c4581-c116-45fc-8db7-9d8498dec5e2" source="pr_cc9e9a00-3053-4901-971c-d32a1b377fc1_p2" target="wnc1_s_wnc4_s96_wnc1_wnc4_sa69"> <start x="10861.25" y="4589.0"/> <end x="10890.25" y="4589.0"/> </arc> <arc class="catalysis" id="modif_aca1785b-de3b-44bf-9e2e-4290544ee54b" source="wnc1_s_wnc4_s98_wnc1_wnc4_sa71" target="pr_cc9e9a00-3053-4901-971c-d32a1b377fc1"> <start x="10847.0" y="4641.0"/> <end x="10846.25" y="4594.0"/> </arc> <arc class="consumption" id="cons_3d9c1c9d-829c-4797-bca2-50785767dcb2" source="wnc1_s_wnc4_s96_wnc1_wnc4_sa69" target="pr_025ec615-073b-41ca-bf88-98426f218123_p1"> <start x="10970.25" y="4589.0"/> <end x="10990.625" y="4588.5874"/> </arc> <arc class="production" id="prod_359da4df-7846-49e2-8bbb-2ab73aa090a8" source="pr_025ec615-073b-41ca-bf88-98426f218123_p2" target="wnc1_s_wnc4_s97_wnc1_wnc4_sa70"> <start x="11020.625" y="4588.5874"/> <end x="11041.0" y="4588.175"/> </arc> <arc class="consumption" id="cons_b6b51795-6cf2-4fb5-9f96-28186f73dbe3" source="wnc1_s_wnc4_s100_wnc1_wnc4_sa74" target="pr_7a6cb276-db2a-4efc-a4e0-523b3fd99ab2_p1"> <start x="11104.0" y="4657.0"/> <end x="11104.0" y="4671.0"/> </arc> <arc class="production" id="prod_5bfa6b82-3b9f-4b4c-b265-a1023c045484" source="pr_7a6cb276-db2a-4efc-a4e0-523b3fd99ab2_p2" target="wnc1_s_wnc4_s102_wnc1_wnc4_sa75"> <start x="11104.0" y="4701.0"/> <end x="11104.0" y="4715.0"/> </arc> <arc class="catalysis" id="modif_cb21101a-66fe-49ee-a050-7cefe598bf60" source="wnc1_s_wnc4_s61_wnc1_wnc4_sa73" target="pr_7a6cb276-db2a-4efc-a4e0-523b3fd99ab2"> <start x="11018.0" y="4687.0"/> <end x="11099.0" y="4686.0"/> </arc> <arc class="consumption" id="cons_9b77231a-0f94-42d8-821d-7651ec2aaae1" source="wnc1_s_wnc4_s61_wnc1_wnc4_sa73" target="pr_ff292172-d956-49fb-b961-7ab7ce39a259_p1"> <start x="10978.0" y="4707.0"/> <end x="10978.0" y="4724.5"/> </arc> <arc class="production" id="prod_e38218b9-ba1d-4df8-9a3b-ed9b6c9c7c34" source="pr_ff292172-d956-49fb-b961-7ab7ce39a259_p2" target="wnc1_s_wnc4_s61_wnc1_wnc4_sa76"> <start x="10978.0" y="4754.5"/> <end x="10978.0" y="4772.0"/> </arc> <arc class="catalysis" id="modif_69321915-556a-44e8-9a67-a1dd14e476d5" source="wnc1_s_wnc4_s99_wnc1_wnc4_sa72" target="pr_ff292172-d956-49fb-b961-7ab7ce39a259"> <start x="10896.0" y="4740.0"/> <end x="10973.0" y="4739.5"/> </arc> <arc class="stimulation" id="direct_ecb2e1b3-d6ec-40fe-9c6a-40549862352c" source="wnc1_s_wnc4_s102_wnc1_wnc4_sa75" target="wnc1_s_wnc4_s104_wnc1_wnc4_sa77"> <start x="11104.0" y="4755.0"/> <end x="11102.518" y="4798.0"/> </arc> <arc class="consumption" id="cons_048da852-fae4-4be1-8281-198803045b23" source="wnc1_s_wnc4_s105_wnc1_wnc4_sa78" target="pr_a5e26f23-be11-42f5-8cf2-a8839911a8af_p1"> <start x="11548.0" y="4014.0"/> <end x="11562.0" y="4014.0"/> </arc> <arc class="production" id="prod_7c4f1d6c-a5d6-46bb-b970-9c0ee937a679" source="pr_a5e26f23-be11-42f5-8cf2-a8839911a8af_p2" target="wnc1_s_wnc4_s106_wnc1_wnc4_sa79"> <start x="11592.0" y="4014.0"/> <end x="11606.0" y="4014.0"/> </arc> <arc class="catalysis" id="modif_85dd7dd0-2f90-4925-b458-2576fd0ff7db" source="wnc1_s_wnc4_s110_wnc1_wnc4_sa83" target="pr_a5e26f23-be11-42f5-8cf2-a8839911a8af"> <start x="11430.0" y="3907.0"/> <end x="11572.0" y="4009.0"/> </arc> <arc class="catalysis" id="modif_4b4db1b3-0166-4598-a306-6b8d85979c04" source="wnc1_s_wnc4_s107_wnc1_wnc4_sa80" target="pr_a5e26f23-be11-42f5-8cf2-a8839911a8af"> <start x="11533.334" y="3907.0"/> <end x="11577.0" y="4009.0"/> </arc> <arc class="catalysis" id="modif_1fb7302f-be8e-4e28-bc28-7539f27ddada" source="wnc1_s_wnc4_s108_wnc1_wnc4_sa81" target="pr_a5e26f23-be11-42f5-8cf2-a8839911a8af"> <start x="11627.704" y="3907.0"/> <end x="11582.0" y="4009.0"/> </arc> <arc class="catalysis" id="modif_886efeb6-d31f-497f-8e20-dec3ef216fa3" source="wnc1_s_wnc4_s109_wnc1_wnc4_sa82" target="pr_a5e26f23-be11-42f5-8cf2-a8839911a8af"> <start x="11740.0" y="3907.0"/> <end x="11582.0" y="4009.0"/> </arc> <arc class="catalysis" id="modif_4d2a4947-dccf-4e2a-b03f-518ada710bde" source="wnc1_s_wnc4_s111_wnc1_wnc4_sa84" target="pr_a5e26f23-be11-42f5-8cf2-a8839911a8af"> <start x="11583.0" y="3841.0"/> <end x="11577.0" y="4009.0"/> </arc> <arc class="consumption" id="cons_1ad5af76-3bc3-44af-8bf5-c2095f84775d" source="wnc1_s_wnc4_s106_wnc1_wnc4_sa79" target="pr_582f3579-501c-4bf9-a229-2106f2e8c74e_p1"> <start x="11656.726" y="4001.5"/> <end x="10953.113" y="3666.0"/> </arc> <arc class="production" id="prod_dabe2fd2-40f6-4504-ada7-df5b89119e90" source="pr_582f3579-501c-4bf9-a229-2106f2e8c74e_p2" target="wnc1_s_wnc4_s115_wnc1_wnc4_sa88"> <start x="10923.113" y="3666.0"/> <end x="10219.5" y="3330.5"/> </arc> <arc class="consumption" id="cons_19a64123-61e7-46f0-ba4d-d825aaedfe17" source="wnc1_s_wnc4_s114_wnc1_wnc4_sa87" target="pr_afd4cb8c-fd68-4303-9149-48e3f7e6ad95_p1"> <start x="10141.5" y="3221.5"/> <next x="10105.75" y="3235.5"/> <end x="10099.375" y="3235.5"/> </arc> <arc class="consumption" id="cons_90952310-d3e4-4222-b39b-7ad9c92a6ca7" source="wnc1_s_wnc4_s116_wnc1_wnc4_sa89" target="pr_afd4cb8c-fd68-4303-9149-48e3f7e6ad95_p1"> <start x="10141.5" y="3271.5"/> <next x="10105.75" y="3235.5"/> <end x="10099.375" y="3235.5"/> </arc> <arc class="production" id="prod_df4c838e-819e-41a6-a8f4-254064fe7d98" source="pr_afd4cb8c-fd68-4303-9149-48e3f7e6ad95_p2" target="wnc1_s_wnc4_s183_wnc1_wnc4_csa2"> <start x="10069.375" y="3235.5"/> <end x="10067.0" y="3235.5"/> </arc> <arc class="stimulation" id="modif_c48e911c-6392-422f-98e7-73963479d65d" source="wnc1_s_wnc4_s124_wnc1_wnc4_csa11" target="pr_afd4cb8c-fd68-4303-9149-48e3f7e6ad95"> <start x="10379.0" y="3129.5"/> <end x="10089.375" y="3240.5"/> </arc> <arc class="consumption" id="addreact_36932cd4-af3b-4cad-9e84-a5b84428f2d7" source="wnc1_s_wnc4_s113_wnc1_wnc4_sa86" target="pr_afd4cb8c-fd68-4303-9149-48e3f7e6ad95_p1"> <start x="10242.5" y="3295.0"/> <end x="10099.375" y="3235.5"/> </arc> <arc class="consumption" id="addreact_8fc7ddf2-8f57-4b7e-8fd2-bad829f7b3fe" source="wnc1_s_wnc4_s115_wnc1_wnc4_sa88" target="pr_afd4cb8c-fd68-4303-9149-48e3f7e6ad95_p1"> <start x="10139.5" y="3330.5"/> <end x="10099.375" y="3235.5"/> </arc> <arc class="consumption" id="addreact_d533e519-7354-471e-81b3-f8b5e6177e28" source="wnc1_s_wnc4_s117_wnc1_wnc4_sa90" target="pr_afd4cb8c-fd68-4303-9149-48e3f7e6ad95_p1"> <start x="10049.5" y="3131.5"/> <end x="10099.375" y="3235.5"/> </arc> <arc class="consumption" id="cons_b889445d-cc2a-4383-9736-c506780077e0" source="wnc1_s_wnc4_s115_wnc1_wnc4_sa88" target="pr_d1b90036-e011-4b39-8d59-96fc56fcf24f_p1"> <start x="10179.5" y="3350.5"/> <end x="10349.25" y="3184.75"/> </arc> <arc class="production" id="prod_d25865c0-f7b5-460c-90b7-fa14bdd557e0" source="pr_d1b90036-e011-4b39-8d59-96fc56fcf24f_p2" target="wnc1_s_wnc4_s43_wnc1_wnc4_sa25"> <start x="10379.25" y="3184.75"/> <end x="10549.0" y="3019.0"/> </arc> <arc class="consumption" id="cons_0593995d-9755-41f0-95e2-51e2c6b1d5c5" source="wnc1_s_wnc4_s119_wnc1_wnc4_sa92" target="pr_5cba62cf-5972-42eb-aa49-76b2f35fa006_p1"> <start x="11548.0" y="4063.0"/> <end x="11562.0" y="4063.0"/> </arc> <arc class="production" id="prod_fd2a1d88-c6f5-4dc4-a72b-56376a510119" source="pr_5cba62cf-5972-42eb-aa49-76b2f35fa006_p2" target="wnc1_s_wnc4_s120_wnc1_wnc4_sa93"> <start x="11592.0" y="4063.0"/> <end x="11606.0" y="4063.0"/> </arc> <arc class="catalysis" id="logicarc_c02f01da-cd6c-4f54-b327-e4c9ae8249ef" source="logicglyph_d777375b-d6e7-4b9e-8b6a-4d430394eee2_p2" target="pr_5cba62cf-5972-42eb-aa49-76b2f35fa006"> <start x="11181.666" y="3829.3335"/> <end x="11577.0" y="4058.0"/> </arc> <arc class="logic arc" id="modif_1828c06b-7e8e-4322-ab77-bc29a605aa8c" source="wnc1_s_wnc4_s44_wnc1_wnc4_sa26" target="logicglyph_d777375b-d6e7-4b9e-8b6a-4d430394eee2_p1"> <start x="10308.0" y="3597.0"/> <end x="11141.666" y="3829.3335"/> </arc> <arc class="logic arc" id="modif_a58d862a-ed22-46e6-a991-c42243c8c53b" source="wnc1_s_wnc4_s111_wnc1_wnc4_sa84" target="logicglyph_d777375b-d6e7-4b9e-8b6a-4d430394eee2_p1"> <start x="11543.0" y="3826.0"/> <end x="11141.666" y="3829.3335"/> </arc> <arc class="consumption" id="cons_2e4e52c7-aec1-476b-bce5-7b21fd0952af" source="wnc1_s_wnc4_s120_wnc1_wnc4_sa93" target="pr_d8797906-6e63-4d4c-b2c7-852a727a0b5a_p1"> <start x="11696.0" y="4063.0"/> <end x="11699.5" y="4063.0"/> </arc> <arc class="production" id="prod_afdaaf7b-209a-4369-89a2-6c20cbccb715" source="pr_d8797906-6e63-4d4c-b2c7-852a727a0b5a_p2" target="wnc1_s_wnc4_s121_wnc1_wnc4_sa94"> <start x="11729.5" y="4063.0"/> <end x="11733.0" y="4063.0"/> </arc> <arc class="consumption" id="cons_af60c4e2-1451-4f17-b6da-3ef117ef107b" source="wnc1_s_wnc4_s121_wnc1_wnc4_sa94" target="pr_b0fe125a-e04c-4bb1-98e0-1369f48dc933_p1"> <start x="11813.0" y="4063.0"/> <end x="11920.5" y="4062.5"/> </arc> <arc class="production" id="prod_de2d0d79-bac2-4ece-b57c-b8000c48b32a" source="pr_b0fe125a-e04c-4bb1-98e0-1369f48dc933_p2" target="wnc1_s_wnc4_s122_wnc1_wnc4_sa95"> <start x="11950.5" y="4062.5"/> <end x="12058.0" y="4062.0"/> </arc> <arc class="consumption" id="cons_10030466-fbe8-43cd-b50e-df5c3a82f9ff" source="wnc1_s_wnc4_s116_wnc1_wnc4_sa89" target="pr_a4938bc8-4d64-4479-b644-df09a096596d_p1"> <start x="10221.5" y="3271.5"/> <next x="10331.5" y="3308.0"/> <end x="10382.22" y="3271.5"/> </arc> <arc class="consumption" id="cons_c706f7d5-3f41-444a-901f-23f37278f1fb" source="wnc1_s_wnc4_s123_wnc1_wnc4_sa96" target="pr_a4938bc8-4d64-4479-b644-df09a096596d_p1"> <start x="10331.5" y="3413.0"/> <next x="10331.5" y="3308.0"/> <end x="10382.22" y="3271.5"/> </arc> <arc class="production" id="prod_7da013b1-378b-440a-a71a-297d7ed2c75d" source="pr_a4938bc8-4d64-4479-b644-df09a096596d_p2" target="wnc1_s_wnc4_s124_wnc1_wnc4_csa11"> <start x="10382.22" y="3241.5"/> <end x="10429.0" y="3209.0"/> </arc> <arc class="consumption" id="cons_2d7b6aef-7f9a-444c-b8f8-24252b775a44" source="wnc1_s_wnc4_s114_wnc1_wnc4_sa87" target="pr_ad6ff6b6-22e4-4ee0-a004-10d10e46c477_p1"> <start x="10295.5" y="3221.5"/> <next x="10361.0" y="3344.5"/> <end x="10381.5" y="3344.5"/> </arc> <arc class="consumption" id="cons_2c57f740-0574-465d-a662-da1465ebf4e5" source="wnc1_s_wnc4_s123_wnc1_wnc4_sa96" target="pr_ad6ff6b6-22e4-4ee0-a004-10d10e46c477_p1"> <start x="10349.0" y="3425.5"/> <next x="10361.0" y="3344.5"/> <end x="10381.5" y="3344.5"/> </arc> <arc class="production" id="prod_fa14aff7-a144-412f-a322-04b8b4b315b0" source="pr_ad6ff6b6-22e4-4ee0-a004-10d10e46c477_p2" target="wnc1_s_wnc4_s127_wnc1_wnc4_csa12"> <start x="10411.5" y="3344.5"/> <end x="10428.0" y="3344.5"/> </arc> <arc class="consumption" id="cons_8ee8f825-565f-453f-a56f-bff3b7d4e6f2" source="wnc1_s_wnc4_s183_wnc1_wnc4_csa2" target="pr_0ff83e43-3ff4-4035-8165-75fa346974bc_p1"> <start x="10067.0" y="3275.25"/> <end x="10077.75" y="3275.25"/> </arc> <arc class="production" id="prod_bae44977-2f95-472b-85b2-15e615648b6a" source="pr_0ff83e43-3ff4-4035-8165-75fa346974bc_p2" target="wnc1_s_wnc4_s115_wnc1_wnc4_sa88"> <start x="10107.75" y="3275.25"/> <next x="10118.5" y="3275.25"/> <end x="10139.5" y="3330.5"/> </arc> <arc class="production" id="prod_bd189fa4-d4d6-4779-838e-86c641c50a26" source="pr_0ff83e43-3ff4-4035-8165-75fa346974bc_p2" target="wnc1_s_wnc4_s116_wnc1_wnc4_sa89"> <start x="10107.75" y="3275.25"/> <next x="10118.5" y="3275.25"/> <end x="10141.5" y="3271.5"/> </arc> <arc class="stimulation" id="modif_fc212848-f07a-41c5-b6de-cb30e15e5140" source="wnc1_s_wnc4_s127_wnc1_wnc4_csa12" target="pr_0ff83e43-3ff4-4035-8165-75fa346974bc"> <start x="10428.0" y="3372.25"/> <end x="10092.75" y="3280.25"/> </arc> <arc class="production" id="addprod_dd9549d4-834b-439f-8143-ece6f77d06a7" source="pr_0ff83e43-3ff4-4035-8165-75fa346974bc_p2" target="wnc1_s_wnc4_s114_wnc1_wnc4_sa87"> <start x="10107.75" y="3275.25"/> <end x="10141.5" y="3231.5"/> </arc> <arc class="production" id="addprod_a069c82e-f55f-4382-b3e6-7f5d2f9b77a8" source="pr_0ff83e43-3ff4-4035-8165-75fa346974bc_p2" target="wnc1_s_wnc4_s113_wnc1_wnc4_sa86"> <start x="10107.75" y="3275.25"/> <end x="10242.5" y="3316.25"/> </arc> <arc class="consumption" id="cons_6953a894-f114-4411-ae9a-6f5b5ab5e13c" source="wnc1_s_wnc4_s123_wnc1_wnc4_sa96" target="pr_8e2710dc-c2cf-4d72-9a49-4ff83846d273_p1"> <start x="10340.25" y="3438.0"/> <next x="10342.0" y="3495.0"/> <end x="10386.0" y="3498.6228"/> </arc> <arc class="consumption" id="cons_5c765071-d3ab-4887-9264-d4d025efe2e3" source="wnc1_s_wnc4_s130_wnc1_wnc4_sa101" target="pr_8e2710dc-c2cf-4d72-9a49-4ff83846d273_p1"> <start x="10306.0" y="3497.0"/> <next x="10342.0" y="3495.0"/> <end x="10386.0" y="3498.6228"/> </arc> <arc class="production" id="prod_9c55f3f8-c48f-4e79-a071-0168e10a0b35" source="pr_8e2710dc-c2cf-4d72-9a49-4ff83846d273_p2" target="wnc1_s_wnc4_s131_wnc1_wnc4_csa13"> <start x="10416.0" y="3498.6228"/> <end x="10456.0" y="3502.0"/> </arc> <arc class="inhibition" id="direct_f08a1b94-1793-482e-a82d-a9c25d0abd55" source="wnc1_s_wnc4_s123_wnc1_wnc4_sa96" target="wnc1_s_wnc4_s134_wnc1_wnc4_sa104"> <start x="10331.5" y="3438.0"/> <end x="9951.0" y="3864.0"/> </arc> <arc class="consumption" id="cons_76295a18-648a-4859-9f88-566a9be12639" source="wnc1_s_wnc4_s141_wnc1_wnc4_sa111" target="pr_a2cbb75e-12c3-4d76-acbf-ec20eff25c7d_p1"> <start x="10573.0" y="3170.0"/> <end x="10573.0" y="3150.5"/> </arc> <arc class="production" id="prod_ec41433d-7200-4909-a28f-c020293ff4cb" source="pr_a2cbb75e-12c3-4d76-acbf-ec20eff25c7d_p2" target="wnc1_s_wnc4_s142_wnc1_wnc4_sa113"> <start x="10573.0" y="3120.5"/> <end x="10573.0" y="3101.0"/> </arc> <arc class="catalysis" id="modif_8fb29b90-e61c-496f-a9c4-3ac272abf3d0" source="wnc1_s_wnc4_s143_wnc1_wnc4_sa114" target="pr_a2cbb75e-12c3-4d76-acbf-ec20eff25c7d"> <start x="10416.0" y="3069.0"/> <end x="10568.0" y="3135.5"/> </arc> <arc class="consumption" id="cons_5c245a72-697a-4ef2-887c-d01cebb635c0" source="wnc1_s_wnc4_s143_wnc1_wnc4_sa114" target="pr_d539a053-8eb9-459c-9b37-5878a5fd7893_p1"> <start x="10336.0" y="3069.0"/> <end x="10290.5" y="3069.0"/> </arc> <arc class="production" id="prod_509613ca-0d22-4df6-8690-e0d5511ec4e2" source="pr_d539a053-8eb9-459c-9b37-5878a5fd7893_p2" target="wnc1_s_wnc4_s12_wnc1_wnc4_sa9"> <start x="10260.5" y="3069.0"/> <end x="10215.0" y="3069.0"/> </arc> <arc class="consumption" id="cons_8f2954f7-e01b-45a0-9bd0-539a6482d6e8" source="wnc1_s_wnc4_s146_wnc1_wnc4_csa14" target="pr_8a07a0f9-1025-4a35-9754-45641fe8bc5d_p1"> <start x="10753.0" y="3021.0"/> <next x="10813.0" y="3035.0"/> <end x="10831.5" y="3048.8254"/> </arc> <arc class="consumption" id="cons_c246d2af-0d8a-4551-b95b-9dbf304414c9" source="wnc1_s_wnc4_s138_wnc1_wnc4_sa108" target="pr_8a07a0f9-1025-4a35-9754-45641fe8bc5d_p1"> <start x="10813.0" y="3090.0"/> <next x="10813.0" y="3035.0"/> <end x="10831.5" y="3048.8254"/> </arc> <arc class="production" id="prod_f70ce82b-2294-499c-84be-f8071a6f9fd3" source="pr_8a07a0f9-1025-4a35-9754-45641fe8bc5d_p2" target="wnc1_s_wnc4_s157_wnc1_wnc4_csa15"> <start x="10861.5" y="3048.8254"/> <end x="10876.0" y="3061.0"/> </arc> <arc class="consumption" id="addreact_714bbcca-101d-44cf-9652-9d0dd53305ef" source="wnc1_s_wnc4_s141_wnc1_wnc4_sa111" target="pr_8a07a0f9-1025-4a35-9754-45641fe8bc5d_p1"> <start x="10613.0" y="3190.0"/> <end x="10831.5" y="3048.8254"/> </arc> <arc class="stimulation" id="direct_9280e9cb-ebc3-4a09-bc17-99f86b113d98" source="wnc1_s_wnc4_s157_wnc1_wnc4_csa15" target="wnc1_s_wnc4_s140_wnc1_wnc4_sa110"> <start x="10931.0" y="3163.0"/> <end x="10931.833" y="3238.0"/> </arc> <arc class="stimulation" id="direct_66128ec6-7218-44d7-ace5-fe313f41b6b8" source="wnc1_s_wnc4_s160_wnc1_wnc4_sa123" target="wnc1_s_wnc4_s158_wnc1_wnc4_sa121"> <start x="10672.0" y="3375.0"/> <end x="10674.392" y="3434.0"/> </arc> <arc class="consumption" id="cons_b0219a30-6104-4212-b94e-689e76c8980a" source="wnc1_s_wnc4_s159_wnc1_wnc4_sa122" target="pr_b0a60752-d4d6-4395-9def-39340f1bf7d0_p1"> <start x="10672.0" y="3281.0"/> <end x="10672.0" y="3293.0"/> </arc> <arc class="production" id="prod_a298e23b-b19f-4e2d-a186-2d64551aa011" source="pr_b0a60752-d4d6-4395-9def-39340f1bf7d0_p2" target="wnc1_s_wnc4_s160_wnc1_wnc4_sa123"> <start x="10672.0" y="3323.0"/> <end x="10672.0" y="3335.0"/> </arc> <arc class="modulation" id="modif_efbb357e-3a85-4676-9d80-fa9c3c706ff5" source="wnc1_s_wnc4_s141_wnc1_wnc4_sa111" target="pr_b0a60752-d4d6-4395-9def-39340f1bf7d0"> <start x="10573.0" y="3210.0"/> <end x="10667.0" y="3308.0"/> </arc> <arc class="consumption" id="cons_60c10724-233c-4ad6-a832-1192cc832762" source="wnc1_s_wnc4_s141_wnc1_wnc4_sa111" target="pr_fca2e6ce-0755-4f9d-a65b-7bb8c5fceb02_p1"> <start x="10613.0" y="3190.0"/> <end x="10664.5" y="3189.5"/> </arc> <arc class="production" id="prod_744aaa10-5eda-4344-be2c-3a1ed042ab32" source="pr_fca2e6ce-0755-4f9d-a65b-7bb8c5fceb02_p2" target="wnc1_s_wnc4_s161_wnc1_wnc4_sa124"> <start x="10694.5" y="3189.5"/> <end x="10746.0" y="3189.0"/> </arc> <arc class="catalysis" id="modif_d182a73d-5b1f-4329-a592-ab22c2c8ad21" source="wnc1_s_wnc4_s162_wnc1_wnc4_sa125" target="pr_fca2e6ce-0755-4f9d-a65b-7bb8c5fceb02"> <start x="10795.0" y="3429.0"/> <end x="10679.537" y="3194.4998"/> </arc> <arc class="consumption" id="cons_d3b8c586-c769-41d0-a4b1-719a7c5300b8" source="wnc1_s_wnc4_s158_wnc1_wnc4_sa121" target="pr_787b4ee7-da40-487e-9a3d-66551accb1e1_p1"> <start x="10715.0" y="3449.0"/> <end x="10720.0" y="3449.0"/> </arc> <arc class="production" id="prod_9d6a2e2d-74e3-49a8-9b84-7a124c22670d" source="pr_787b4ee7-da40-487e-9a3d-66551accb1e1_p2" target="wnc1_s_wnc4_s162_wnc1_wnc4_sa125"> <start x="10750.0" y="3449.0"/> <end x="10755.0" y="3449.0"/> </arc> <arc class="consumption" id="cons_d124c222-08b5-4100-ada8-35b284881497" source="wnc1_s_wnc4_s161_wnc1_wnc4_sa124" target="pr_a8733c95-581b-4c69-95a6-2fe759dcc9e5_p1"> <start x="10786.0" y="3209.0"/> <end x="10894.0" y="3383.5"/> </arc> <arc class="production" id="prod_1fec4b62-b896-4823-b014-7239090bb344" source="pr_a8733c95-581b-4c69-95a6-2fe759dcc9e5_p2" target="wnc1_s_wnc4_s163_wnc1_wnc4_sa126"> <start x="10894.0" y="3413.5"/> <end x="11002.0" y="3588.0"/> </arc> <arc class="consumption" id="cons_99941be3-d1fd-4ee1-8e54-839a12c926fe" source="wnc1_s_wnc4_s163_wnc1_wnc4_sa126" target="pr_7456d169-04b0-4dec-9a5a-de29c6213bb8_p1"> <start x="10962.0" y="3608.0"/> <end x="10833.5" y="3536.0"/> </arc> <arc class="production" id="prod_3404e50a-b4c4-4b90-97d0-75fc2139cf03" source="pr_7456d169-04b0-4dec-9a5a-de29c6213bb8_p2" target="wnc1_s_wnc4_s158_wnc1_wnc4_sa121"> <start x="10803.5" y="3536.0"/> <end x="10675.0" y="3464.0"/> </arc> <arc class="consumption" id="cons_e324e1e0-55b7-4a3d-ae8a-2e284574f64a" source="wnc1_s_wnc4_s164_wnc1_wnc4_sa127" target="pr_5f6ad765-50a9-4756-a63f-8e53afb0c695_p1"> <start x="10872.0" y="3608.0"/> <next x="10906.0" y="3608.0"/> <end x="10912.354" y="3629.0"/> </arc> <arc class="consumption" id="cons_20c84603-7b28-44c9-b0b2-b946b23c977d" source="wnc1_s_wnc4_s163_wnc1_wnc4_sa126" target="pr_5f6ad765-50a9-4756-a63f-8e53afb0c695_p1"> <start x="10962.0" y="3608.0"/> <next x="10906.0" y="3608.0"/> <end x="10912.354" y="3629.0"/> </arc> <arc class="production" id="prod_4ef02475-7a48-49d9-b041-fe0907c91d58" source="pr_5f6ad765-50a9-4756-a63f-8e53afb0c695_p2" target="wnc1_s_wnc4_s166_wnc1_wnc4_csa16"> <start x="10912.354" y="3659.0"/> <end x="10918.0" y="3676.0"/> </arc> <arc class="consumption" id="cons_5466ccbf-8577-449c-8040-54762447bb78" source="wnc1_s_wnc4_s141_wnc1_wnc4_sa111" target="pr_40ab64f9-97f4-4529-8538-d5c230c81333_p1"> <start x="10573.0" y="3210.0"/> <next x="10418.0" y="3641.0"/> <end x="10428.104" y="3659.5"/> </arc> <arc class="consumption" id="cons_be8d82fe-a3d1-4bd7-89af-5b3091ef4e83" source="wnc1_s_wnc4_s169_wnc1_wnc4_sa130" target="pr_40ab64f9-97f4-4529-8538-d5c230c81333_p1"> <start x="10336.0" y="3641.0"/> <next x="10418.0" y="3641.0"/> <end x="10428.104" y="3659.5"/> </arc> <arc class="production" id="prod_47ebec1d-7e03-4a72-867a-03a9c525dd4e" source="pr_40ab64f9-97f4-4529-8538-d5c230c81333_p2" target="wnc1_s_wnc4_s175_wnc1_wnc4_csa17"> <start x="10428.104" y="3689.5"/> <end x="10437.0" y="3704.0"/> </arc> <arc class="consumption" id="addreact_bfde6f0f-66e1-46f8-a1a7-40e7b89ec930" source="wnc1_s_wnc4_s170_wnc1_wnc4_sa131" target="pr_40ab64f9-97f4-4529-8538-d5c230c81333_p1"> <start x="10201.0" y="3641.0"/> <end x="10428.104" y="3659.5"/> </arc> <arc class="consumption" id="addreact_31995dd4-1fe0-4e2b-a90b-cf382005964a" source="wnc1_s_wnc4_s171_wnc1_wnc4_sa132" target="pr_40ab64f9-97f4-4529-8538-d5c230c81333_p1"> <start x="10201.0" y="3698.0"/> <end x="10428.104" y="3659.5"/> </arc> <arc class="consumption" id="addreact_3aecaf31-347c-4f22-9860-19ea1fa1a19f" source="wnc1_s_wnc4_s172_wnc1_wnc4_sa134" target="pr_40ab64f9-97f4-4529-8538-d5c230c81333_p1"> <start x="10201.0" y="3762.0"/> <end x="10428.104" y="3659.5"/> </arc> <arc class="consumption" id="addreact_327e4df2-97ea-4739-9fd5-da257ed6c8cc" source="wnc1_s_wnc4_s130_wnc1_wnc4_sa133" target="pr_40ab64f9-97f4-4529-8538-d5c230c81333_p1"> <start x="10336.0" y="3698.0"/> <end x="10428.104" y="3659.5"/> </arc> <arc class="consumption" id="addreact_46af64ce-2176-4b62-823a-6647764db73e" source="wnc1_s_wnc4_s173_wnc1_wnc4_sa135" target="pr_40ab64f9-97f4-4529-8538-d5c230c81333_p1"> <start x="10336.0" y="3762.0"/> <end x="10428.104" y="3659.5"/> </arc> <arc class="consumption" id="cons_99f0b161-ab29-444d-8e34-383f6b197593" source="wca1_s_wca1_s1706_wca1_wca1_csa1" target="pr_1758ef67-a3ea-4384-9023-c8bdce59ed34_p1"> <start x="12453.0" y="680.5"/> <next x="12474.0" y="702.0"/> <end x="12462.797" y="710.5"/> </arc> <arc class="consumption" id="cons_56ba3fed-2d52-494f-bb9a-01b848ef7ef8" source="wca1_s_wca1_s1_wca1_wca1_sa1" target="pr_1758ef67-a3ea-4384-9023-c8bdce59ed34_p1"> <start x="12727.0" y="699.5"/> <next x="12474.0" y="702.0"/> <end x="12462.797" y="710.5"/> </arc> <arc class="production" id="prod_cbcfd7bf-a0c9-4705-bcf0-98179eb0b948" source="pr_1758ef67-a3ea-4384-9023-c8bdce59ed34_p2" target="wca1_s_wca1_s1707_wca1_wca1_csa2"> <start x="12462.797" y="740.5"/> <end x="12453.5" y="745.0"/> </arc> <arc class="consumption" id="cons_db97dac5-a743-44ce-9aad-e67ef255f4ad" source="wca1_s_wca1_s1707_wca1_wca1_csa2" target="pr_c639c461-92bd-408a-99e4-0844e47d0f43_p1"> <start x="12453.5" y="936.0"/> <end x="12453.25" y="942.8125"/> </arc> <arc class="production" id="prod_0ad61c74-ffbd-4523-a2b9-7e2afd0cc5b2" source="pr_c639c461-92bd-408a-99e4-0844e47d0f43_p2" target="wca1_s_wca1_s1708_wca1_wca1_csa3"> <start x="12453.25" y="972.8125"/> <end x="12453.0" y="979.625"/> </arc> <arc class="consumption" id="cons_8ed72d87-5982-4512-aa18-fad2175c2523" source="wca1_s_wca1_s1708_wca1_wca1_csa3" target="pr_6902a6a3-24c7-4c4f-ba1d-5c976fd9e55a_p1"> <start x="12453.0" y="1162.625"/> <end x="12453.0" y="1166.2812"/> </arc> <arc class="production" id="prod_36f4a634-d764-48a3-a927-d4f4a817ccca" source="pr_6902a6a3-24c7-4c4f-ba1d-5c976fd9e55a_p2" target="wca1_s_wca1_s1709_wca1_wca1_csa4"> <start x="12453.0" y="1196.2812"/> <end x="12453.0" y="1199.9375"/> </arc> <arc class="consumption" id="cons_e9228773-5fbb-433d-834f-d10c97e84fdc" source="wca1_s_wca1_s1709_wca1_wca1_csa4" target="pr_943cb431-4ed0-45ac-b997-04c2af662a4a_p1"> <start x="12453.0" y="1383.9375"/> <end x="12453.25" y="1385.0938"/> </arc> <arc class="production" id="prod_0030abc5-425a-49fa-b274-d337b7e97552" source="pr_943cb431-4ed0-45ac-b997-04c2af662a4a_p2" target="wca1_s_wca1_s1710_wca1_wca1_csa5"> <start x="12453.25" y="1415.0938"/> <end x="12453.5" y="1416.25"/> </arc> <arc class="consumption" id="cons_706dce93-8b83-4dd9-998d-7b99c0aa1d8d" source="wca1_s_wca1_s1710_wca1_wca1_csa5" target="pr_447beb0f-0656-48f2-aad9-316a6deab6d2_p1"> <start x="12453.5" y="1597.25"/> <end x="12453.25" y="1602.4062"/> </arc> <arc class="production" id="prod_896ee436-deff-4f35-8fbc-cb41efd27fa3" source="pr_447beb0f-0656-48f2-aad9-316a6deab6d2_p2" target="wca1_s_wca1_s1711_wca1_wca1_csa6"> <start x="12453.25" y="1632.4062"/> <end x="12453.0" y="1637.5625"/> </arc> <arc class="consumption" id="cons_6a4a4ee6-0f04-4c9e-944c-1fb94cea6b59" source="wca1_s_wca1_s1711_wca1_wca1_csa6" target="pr_375b3849-b62b-4e2b-8c86-7d821f497b0f_p1"> <start x="12453.0" y="1816.5625"/> <end x="12453.0" y="1825.2188"/> </arc> <arc class="production" id="prod_c9eb89a8-de8d-446a-be17-0740bc63fef8" source="pr_375b3849-b62b-4e2b-8c86-7d821f497b0f_p2" target="wca1_s_wca1_s1712_wca1_wca1_csa7"> <start x="12453.0" y="1855.2188"/> <end x="12453.0" y="1863.875"/> </arc> <arc class="consumption" id="cons_02f0ab3e-e88e-44b1-a868-76096222b7e8" source="wca1_s_wca1_s1712_wca1_wca1_csa7" target="pr_62298677-32da-4155-8b43-33bc1f9df0a1_p1"> <start x="12453.0" y="2050.875"/> <end x="12452.5" y="2055.5312"/> </arc> <arc class="production" id="prod_ea44ef0f-2552-44b6-b062-a0d040845b74" source="pr_62298677-32da-4155-8b43-33bc1f9df0a1_p2" target="wca1_s_wca1_s1713_wca1_wca1_csa8"> <start x="12452.5" y="2085.5312"/> <end x="12452.0" y="2090.1875"/> </arc> <arc class="consumption" id="cons_95e3f3fc-6467-4d39-96e4-80695858c580" source="wca1_s_wca1_s1713_wca1_wca1_csa8" target="pr_0838dddf-244f-46d1-a9eb-498e12ec2018_p1"> <start x="12452.0" y="2277.1875"/> <end x="12452.5" y="2281.8438"/> </arc> <arc class="production" id="prod_4f28c7b3-f8ad-4920-9f4a-c7a801ad6ec7" source="pr_0838dddf-244f-46d1-a9eb-498e12ec2018_p2" target="wca1_s_wca1_s1714_wca1_wca1_csa9"> <start x="12452.5" y="2311.8438"/> <end x="12453.0" y="2316.5"/> </arc> <arc class="consumption" id="cons_3a0c59e8-88a7-48a8-a28b-57b6ad8ea003" source="wca1_s_wca1_s1714_wca1_wca1_csa9" target="pr_f438d5cf-c705-41aa-9a0b-08b9c45992b9_p1"> <start x="12549.0" y="2409.0"/> <end x="12634.416" y="2409.0"/> </arc> <arc class="production" id="prod_25d06606-bf1a-4872-9198-85e255d1840e" source="pr_f438d5cf-c705-41aa-9a0b-08b9c45992b9_p2" target="wca1_s_wca1_s1715_wca1_wca1_csa10"> <start x="12664.416" y="2409.0"/> <end x="12749.833" y="2409.0"/> </arc> <arc class="consumption" id="cons_71ee680a-cad1-40a6-97d3-1d922993a255" source="wca1_s_wca1_s1715_wca1_wca1_csa10" target="pr_8711dbf9-9f40-4730-aad0-44d1b425ce45_p1"> <start x="12943.833" y="2409.0"/> <end x="12975.75" y="2409.0"/> </arc> <arc class="production" id="prod_5fa6b883-5a16-4d4f-9e10-be0ad5a762d9" source="pr_8711dbf9-9f40-4730-aad0-44d1b425ce45_p2" target="wca1_s_wca1_s1716_wca1_wca1_csa11"> <start x="13005.75" y="2409.0"/> <end x="13037.667" y="2409.0"/> </arc> <arc class="consumption" id="cons_0710626c-00c8-4bcd-a083-b454358daabc" source="wca1_s_wca1_s1704_wca1_wca1_csa13" target="pr_4e9dffb5-f258-48ab-8914-23a3c3a0d707_p1"> <start x="12600.25" y="308.0"/> <end x="12574.625" y="327.5"/> </arc> <arc class="production" id="prod_98eb06de-0401-4bb3-b235-6bad2d9cd01d" source="pr_4e9dffb5-f258-48ab-8914-23a3c3a0d707_p2" target="wca1_s_wca1_s1705_wca1_wca1_csa14"> <start x="12574.625" y="357.5"/> <end x="12549.0" y="377.0"/> </arc> <arc class="catalysis" id="modif_cb752bea-e467-4576-aef7-146edd1e40e3" source="wca1_s_wca1_s156_wca1_wca1_sa125" target="pr_4e9dffb5-f258-48ab-8914-23a3c3a0d707"> <start x="12623.0" y="490.5"/> <end x="12578.639" y="345.48135"/> </arc> <arc class="consumption" id="cons_93000b3e-a84c-45ea-bdae-3554cccfc6ea" source="wca1_s_wca1_s1705_wca1_wca1_csa14" target="pr_65e0684b-8497-4f3c-a447-3beb708b8cc1_p1"> <start x="12453.0" y="458.5"/> <end x="12453.0" y="473.0"/> </arc> <arc class="production" id="prod_a56a3183-9a2e-4c2e-a089-c052b8d2ba7e" source="pr_65e0684b-8497-4f3c-a447-3beb708b8cc1_p2" target="wca1_s_wca1_s1706_wca1_wca1_csa1"> <start x="12453.0" y="503.0"/> <end x="12453.0" y="517.5"/> </arc> <arc class="consumption" id="cons_58552732-1cc3-42aa-b038-5e8a2e1d9671" source="wca1_s_wca1_s1704_wca1_wca1_csa13" target="pr_ab8033f4-574a-47ff-8eeb-b0531c69ae27_p1"> <start x="12696.25" y="389.5"/> <next x="12926.0" y="597.0"/> <end x="12939.0" y="595.6538"/> </arc> <arc class="consumption" id="cons_3ae0c088-2054-4622-951f-31568d187472" source="wca1_s_wca1_s108_wca1_wca1_csa16" target="pr_ab8033f4-574a-47ff-8eeb-b0531c69ae27_p1"> <start x="12880.0" y="598.0"/> <next x="12926.0" y="597.0"/> <end x="12939.0" y="595.6538"/> </arc> <arc class="production" id="prod_2eeaecc0-c443-428f-9e45-18a0401b0a0a" source="pr_ab8033f4-574a-47ff-8eeb-b0531c69ae27_p2" target="wca1_s_wca1_s1703_wca1_wca1_csa17"> <start x="12969.0" y="595.6538"/> <end x="12978.0" y="594.5"/> </arc> <arc class="inhibition" id="modif_1d4c3fc8-ee61-4f30-93e5-96411c90e4cb" source="wca1_s_wca1_s655_wca1_wca1_sa493" target="pr_ab8033f4-574a-47ff-8eeb-b0531c69ae27"> <start x="13262.25" y="924.0"/> <end x="12959.234" y="600.40796"/> </arc> <arc class="consumption" id="cons_49c79808-73ad-4c75-9813-984322a99f55" source="wca1_s_wca1_s1703_wca1_wca1_csa17" target="pr_52863cd9-e859-46dc-995d-97dddbac80a9_p1"> <start x="13106.5" y="678.5"/> <end x="13091.25" y="696.25"/> </arc> <arc class="production" id="prod_6927fe8b-cff0-4108-8971-104af0c31ee9" source="pr_52863cd9-e859-46dc-995d-97dddbac80a9_p2" target="wca1_s_wca1_s109_wca1_wca1_csa18"> <start x="13091.25" y="726.25"/> <end x="13076.0" y="744.0"/> </arc> <arc class="consumption" id="cons_0f7aaa6d-b5d4-452e-bf2d-7997145192da" source="wca1_s_wca1_s109_wca1_wca1_csa18" target="pr_9f5f3687-a094-4599-99e9-14d3e2879e78_p1"> <start x="12978.0" y="827.0"/> <end x="12965.777" y="822.8633"/> </arc> <arc class="production" id="prod_31eda107-c351-446e-915f-487d0e73e7c7" source="pr_9f5f3687-a094-4599-99e9-14d3e2879e78_p2" target="wca1_s_wca1_s490_wca1_wca1_sa63"> <start x="12965.777" y="792.8633"/> <next x="12953.555" y="788.72656"/> <end x="12951.25" y="504.5"/> </arc> <arc class="production" id="prod_54d74c8b-f223-4223-adbe-d5c1609bdaea" source="pr_9f5f3687-a094-4599-99e9-14d3e2879e78_p2" target="wca1_s_wca1_s1702_wca1_wca1_csa12"> <start x="12965.777" y="792.8633"/> <next x="12953.555" y="788.72656"/> <end x="12917.5" y="390.5"/> </arc> <arc class="production" id="addprod_f6d87c06-cb97-4eb2-b88b-1ca6018387a3" source="pr_9f5f3687-a094-4599-99e9-14d3e2879e78_p2" target="wca1_s_wca1_s108_wca1_wca1_csa16"> <start x="12965.777" y="792.8633"/> <end x="12880.0" y="598.0"/> </arc> <arc class="consumption" id="cons_4649f856-54b4-4594-8355-a8add37142c6" source="wca1_s_wca1_s1711_wca1_wca1_csa6" target="pr_966018ce-0c9e-4ffd-b39b-e8efab1c895d_p1"> <start x="12549.0" y="1727.0625"/> <next x="12752.5" y="1717.5"/> <end x="12785.0" y="1717.761"/> </arc> <arc class="consumption" id="cons_a8f8a99a-fe39-4e76-8e7b-51f1efa96933" source="wca1_s_wca1_s1724_wca1_wca1_csa19" target="pr_966018ce-0c9e-4ffd-b39b-e8efab1c895d_p1"> <start x="12752.5" y="1571.0"/> <next x="12752.5" y="1717.5"/> <end x="12785.0" y="1717.761"/> </arc> <arc class="production" id="prod_79954ac9-f05e-428d-9d9f-f1c5958eb75d" source="pr_966018ce-0c9e-4ffd-b39b-e8efab1c895d_p2" target="wca1_s_wca1_s1722_wca1_wca1_csa20"> <start x="12815.0" y="1717.761"/> <end x="12843.5" y="1718.0"/> </arc> <arc class="consumption" id="cons_0a4aa8d8-1840-4cd5-b464-4aae659dc6e1" source="wca1_s_wca1_s1722_wca1_wca1_csa20" target="pr_f8c6c2f4-7dc2-4262-b488-c1a55006048f_p1"> <start x="12981.5" y="1636.5"/> <end x="12981.5" y="1617.5"/> </arc> <arc class="production" id="prod_a1eded10-c7c2-492a-b7b9-043e1c6f1fef" source="pr_f8c6c2f4-7dc2-4262-b488-c1a55006048f_p2" target="wca1_s_wca1_s1723_wca1_wca1_csa21"> <start x="12981.5" y="1587.5"/> <end x="12981.5" y="1568.5"/> </arc> <arc class="consumption" id="cons_431d05c9-ecc4-4c9e-876e-0934a4d8630e" source="wca1_s_wca1_s1723_wca1_wca1_csa21" target="pr_c51fa054-ec19-4d4d-b469-2476cbd7b684_p1"> <start x="12981.5" y="1405.5"/> <end x="12960.854" y="1352.0"/> </arc> <arc class="production" id="prod_68fb3e36-4399-4694-97a7-dedd52f94f2c" source="pr_c51fa054-ec19-4d4d-b469-2476cbd7b684_p2" target="wca1_s_wca1_s1724_wca1_wca1_csa19"> <start x="12960.854" y="1322.0"/> <next x="12940.206" y="1268.5"/> <end x="12804.0" y="1491.5"/> </arc> <arc class="production" id="prod_2b930da4-aab0-4760-898d-c063d9ebe327" source="pr_c51fa054-ec19-4d4d-b469-2476cbd7b684_p2" target="wca1_s_wca1_s1_wca1_wca1_sa1"> <start x="12960.854" y="1322.0"/> <next x="12940.206" y="1268.5"/> <end x="12773.089" y="719.5"/> </arc> <arc class="production" id="addprod_77ea7444-ff13-49f8-8d97-7a11f497ebbf" source="pr_c51fa054-ec19-4d4d-b469-2476cbd7b684_p2" target="wca1_s_wca1_s1706_wca1_wca1_csa1"> <start x="12960.854" y="1322.0"/> <end x="12549.0" y="680.5"/> </arc> <arc class="consumption" id="cons_a2a48613-168b-48a2-918a-300f47145a46" source="wca1_s_wca1_s171_wca1_wca1_sa137" target="pr_81b06769-fe5f-48d0-8ec0-63ebd5e7ab0e_p1"> <start x="13416.0" y="96.0"/> <next x="13479.75" y="96.00001"/> <next x="13479.75" y="217.50003"/> <end x="13493.598" y="217.53708"/> </arc> <arc class="consumption" id="cons_c24eeab8-5444-4b0d-ad29-1f445e7a7c89" source="wca1_s_wca1_s1497_wca1_wca1_csa25" target="pr_81b06769-fe5f-48d0-8ec0-63ebd5e7ab0e_p1"> <start x="13683.5" y="298.0"/> <next x="13683.5" y="325.0"/> <next x="13479.75" y="325.00003"/> <next x="13479.75" y="217.50003"/> <end x="13493.598" y="217.53708"/> </arc> <arc class="production" id="prod_087a7517-b35e-40d4-8368-58eee5fde8dd" source="pr_81b06769-fe5f-48d0-8ec0-63ebd5e7ab0e_p2" target="wca1_s_wca1_s181_wca1_wca1_csa26"> <start x="13523.598" y="217.53708"/> <next x="13533.446" y="217.56897"/> <next x="13533.438" y="223.07625"/> <end x="13863.5" y="223.5"/> </arc> <arc class="consumption" id="addreact_e2db0bfb-926a-4f79-b9e7-8ffe692b4c3f" source="wca1_s_wca1_s211_wca1_wca1_csa28" target="pr_81b06769-fe5f-48d0-8ec0-63ebd5e7ab0e_p1"> <start x="13463.5" y="219.0"/> <end x="13493.598" y="217.53708"/> </arc> <arc class="consumption" id="addreact_c3397520-8160-4b36-90c1-a3dc43049702" source="wca1_s_wca1_s220_wca1_wca1_sa174" target="pr_81b06769-fe5f-48d0-8ec0-63ebd5e7ab0e_p1"> <start x="13573.322" y="331.0"/> <end x="13493.598" y="217.53708"/> </arc> <arc class="consumption" id="addreact_91de70b6-9957-4414-bb63-dfd115df7ab6" source="wca1_s_wca1_s1370_wca1_wca1_sa648" target="pr_81b06769-fe5f-48d0-8ec0-63ebd5e7ab0e_p1"> <start x="13450.0" y="371.0"/> <end x="13493.598" y="217.53708"/> </arc> <arc class="production" id="addprod_63977a85-6642-4db9-bd55-c9096355bd8a" source="pr_81b06769-fe5f-48d0-8ec0-63ebd5e7ab0e_p2" target="wca1_s_wca1_s221_wca1_wca1_sa175"> <start x="13523.598" y="217.53708"/> <end x="13740.5" y="336.92422"/> </arc> <arc class="consumption" id="cons_230400b2-642e-47a9-ae17-f1745c6b5110" source="wca1_s_wca1_s189_wca1_wca1_sa152" target="pr_da22cb5c-c100-4b07-919b-3b906e29b95e_p1"> <start x="13353.0" y="581.0"/> <end x="13367.375" y="581.0"/> </arc> <arc class="production" id="prod_2bfd51de-d436-4f9b-a141-fc80c05de079" source="pr_da22cb5c-c100-4b07-919b-3b906e29b95e_p2" target="wca1_s_wca1_s190_wca1_wca1_sa153"> <start x="13397.375" y="581.0"/> <end x="13411.75" y="581.0"/> </arc> <arc class="catalysis" id="modif_23829646-e699-4f72-9286-2a80ca66d1ef" source="wca1_s_wca1_s865_wca1_wca1_csa59" target="pr_da22cb5c-c100-4b07-919b-3b906e29b95e"> <start x="13384.0" y="655.0"/> <end x="13382.375" y="586.0"/> </arc> <arc class="catalysis" id="modif_2fba19f3-8283-4a9f-bd3c-fab2e680d39f" source="wca1_s_wca1_s885_wca1_wca1_sa552" target="pr_da22cb5c-c100-4b07-919b-3b906e29b95e"> <start x="13382.0" y="544.0"/> <end x="13382.375" y="576.0"/> </arc> <arc class="consumption" id="cons_345902b6-111b-476a-80d5-1b587014dbba" source="wca1_s_wca1_s889_wca1_wca1_csa29" target="pr_7c3de2dd-aa06-456d-90eb-411efa413df8_p1"> <start x="13661.25" y="649.0"/> <next x="14205.0" y="221.5"/> <end x="14231.25" y="222.02548"/> </arc> <arc class="consumption" id="cons_f96ce83a-38d8-47f3-9e89-24f1a8599bb2" source="wca1_s_wca1_s181_wca1_wca1_csa26" target="pr_7c3de2dd-aa06-456d-90eb-411efa413df8_p1"> <start x="14145.5" y="223.5"/> <next x="14205.0" y="221.5"/> <end x="14231.25" y="222.02548"/> </arc> <arc class="production" id="prod_1aefaf15-b76c-4a16-9ccc-cbbb5fb6c2a0" source="pr_7c3de2dd-aa06-456d-90eb-411efa413df8_p2" target="wca1_s_wca1_s1502_wca1_wca1_csa27"> <start x="14261.25" y="222.02548"/> <end x="14283.5" y="222.5"/> </arc> <arc class="necessary stimulation" id="modif_f8d32ce0-308c-466f-99db-d5353dba544f" source="wca1_s_wca1_s1654_wca1_wca1_sa652" target="pr_7c3de2dd-aa06-456d-90eb-411efa413df8"> <start x="14114.536" y="391.0"/> <end x="14246.187" y="227.02507"/> </arc> <arc class="consumption" id="addreact_afb153f9-96df-4242-9fdc-f1ca9f1f7a4e" source="wca1_s_wca1_s988_wca1_wca1_csa62" target="pr_7c3de2dd-aa06-456d-90eb-411efa413df8_p1"> <start x="15031.0" y="1037.75"/> <end x="14231.25" y="222.02548"/> </arc> <arc class="production" id="addprod_1196508d-71cf-4b5e-bcde-b9ba5b3159e4" source="pr_7c3de2dd-aa06-456d-90eb-411efa413df8_p2" target="wca1_s_wca1_s1187_wca1_wca1_csa63"> <start x="14261.25" y="222.02548"/> <end x="13745.0" y="662.0"/> </arc> <arc class="production" id="addprod_4aa9dc46-9341-4253-be17-c090cbdbe729" source="pr_7c3de2dd-aa06-456d-90eb-411efa413df8_p2" target="wca1_s_wca1_s226_wca1_wca1_csa30"> <start x="14261.25" y="222.02548"/> <end x="13735.0" y="556.0"/> </arc> <arc class="consumption" id="cons_aa6b7114-2ae0-4f21-82ad-9fe49e882784" source="wca1_s_wca1_s190_wca1_wca1_sa153" target="pr_946da9d8-90ed-44ff-ab9d-d7c78799a782_p1"> <start x="13491.75" y="581.0"/> <next x="13575.0" y="582.0"/> <end x="13606.525" y="602.5"/> </arc> <arc class="consumption" id="cons_54b79677-df26-4f2d-a86d-9d5873af8584" source="wca1_s_wca1_s226_wca1_wca1_csa30" target="pr_946da9d8-90ed-44ff-ab9d-d7c78799a782_p1"> <start x="13683.0" y="578.0"/> <next x="13575.0" y="582.0"/> <end x="13606.525" y="602.5"/> </arc> <arc class="production" id="prod_2bae7107-39d1-4591-b0de-5b96c22477d3" source="pr_946da9d8-90ed-44ff-ab9d-d7c78799a782_p2" target="wca1_s_wca1_s889_wca1_wca1_csa29"> <start x="13606.525" y="632.5"/> <end x="13634.5" y="649.0"/> </arc> <arc class="consumption" id="addreact_190f33b7-7145-4edc-85e2-e305bc2788f3" source="wca1_s_wca1_s886_wca1_wca1_sa553" target="pr_946da9d8-90ed-44ff-ab9d-d7c78799a782_p1"> <start x="13506.0" y="719.0"/> <end x="13606.525" y="602.5"/> </arc> <arc class="consumption" id="cons_1b9374a1-599e-45b4-a9c3-0e15936fbcb6" source="wca1_s_wca1_s229_wca1_wca1_sa181" target="pr_2ddc6798-62d0-40fd-beea-da4b6ce657e7_p1"> <start x="15095.0" y="497.0"/> <end x="15063.0" y="531.5"/> </arc> <arc class="production" id="prod_e63c694d-a729-4b1c-938c-ca8227863670" source="pr_2ddc6798-62d0-40fd-beea-da4b6ce657e7_p2" target="wca1_s_wca1_s230_wca1_wca1_sa182"> <start x="15063.0" y="561.5"/> <end x="15031.0" y="596.0"/> </arc> <arc class="catalysis" id="modif_eb708554-8a24-42d2-a126-20bd25de2f81" source="wca1_s_wca1_s227_wca1_wca1_sa179" target="pr_2ddc6798-62d0-40fd-beea-da4b6ce657e7"> <start x="14960.0" y="567.0"/> <end x="15058.801" y="543.7855"/> </arc> <arc class="consumption" id="cons_f1278e1d-a91b-40b5-a2c2-dfdf66f403a3" source="wca1_s_wca1_s230_wca1_wca1_sa182" target="pr_bb709b51-c7be-451a-b8a6-5302f66699f1_p1"> <start x="15101.0" y="596.0"/> <end x="15067.0" y="639.0"/> </arc> <arc class="production" id="prod_0e52d8b1-a134-45fc-942a-54abbd9a1cd4" source="pr_bb709b51-c7be-451a-b8a6-5302f66699f1_p2" target="wca1_s_wca1_s231_wca1_wca1_sa183"> <start x="15067.0" y="669.0"/> <end x="15033.0" y="712.0"/> </arc> <arc class="catalysis" id="modif_ee72049b-dc48-4d2f-85d3-4216a245692d" source="wca1_s_wca1_s228_wca1_wca1_sa180" target="pr_bb709b51-c7be-451a-b8a6-5302f66699f1"> <start x="14952.0" y="702.0"/> <end x="15062.687" y="651.4714"/> </arc> <arc class="consumption" id="cons_5a75ebef-abde-4370-abd1-1669edc653b7" source="wca1_s_wca1_s1502_wca1_wca1_csa27" target="pr_7c3ee7b4-c87e-4b64-83db-0c0d5b77aef0_p1"> <start x="14605.0" y="222.5"/> <end x="14622.25" y="222.25"/> </arc> <arc class="production" id="prod_c45b359b-fd9a-4dbb-a38c-6901993cee4c" source="pr_7c3ee7b4-c87e-4b64-83db-0c0d5b77aef0_p2" target="wca1_s_wca1_s232_wca1_wca1_csa33"> <start x="14652.25" y="222.25"/> <end x="14669.5" y="222.0"/> </arc> <arc class="catalysis" id="modif_6f2e6564-59d0-4419-879c-f208b6d64bfb" source="wca1_s_wca1_s1502_wca1_wca1_csa27" target="pr_7c3ee7b4-c87e-4b64-83db-0c0d5b77aef0"> <start x="14444.25" y="338.0"/> <next x="14444.233" y="356.98688"/> <next x="14637.179" y="357.15067"/> <end x="14637.289" y="227.24985"/> </arc> <arc class="consumption" id="cons_1e9b6db8-c853-4f72-be42-7191222d065e" source="wca1_s_wca1_s232_wca1_wca1_csa33" target="pr_16eadab6-1b1e-4210-9d02-e4ca08d5048f_p1"> <start x="14832.0" y="337.5"/> <end x="14475.0" y="492.5"/> </arc> <arc class="production" id="prod_da3438bf-c3c9-45e0-a07d-727288a5e4fb" source="pr_16eadab6-1b1e-4210-9d02-e4ca08d5048f_p2" target="wca1_s_wca1_s1728_wca1_wca1_csa32"> <start x="14445.0" y="492.5"/> <end x="14088.0" y="647.5"/> </arc> <arc class="catalysis" id="modif_e179b4a7-231a-43e7-8c87-f7f770557b10" source="wca1_s_wca1_s973_wca1_wca1_csa60" target="pr_16eadab6-1b1e-4210-9d02-e4ca08d5048f"> <start x="15066.5" y="866.0"/> <end x="14461.923" y="497.1154"/> </arc> <arc class="catalysis" id="modif_f0ffd0f8-3a79-4cd2-a4e1-2c08a0aa8bda" source="wca1_s_wca1_s226_wca1_wca1_csa30" target="pr_16eadab6-1b1e-4210-9d02-e4ca08d5048f"> <start x="13787.0" y="578.0"/> <end x="14453.462" y="489.80768"/> </arc> <arc class="inhibition" id="modif_765f2657-3ee9-40c9-a7f5-b9228ce4e692" source="wca1_s_wca1_s655_wca1_wca1_sa493" target="pr_16eadab6-1b1e-4210-9d02-e4ca08d5048f"> <start x="13262.25" y="924.0"/> <end x="14461.923" y="497.1154"/> </arc> <arc class="catalysis" id="modif_d5c63f76-676f-419e-963d-c196280e0255" source="wca1_s_wca1_s988_wca1_wca1_csa62" target="pr_16eadab6-1b1e-4210-9d02-e4ca08d5048f"> <start x="15031.0" y="1037.75"/> <end x="14461.923" y="497.1154"/> </arc> <arc class="consumption" id="addreact_7f6801d3-5576-478a-ab7b-4d08f8e8f7df" source="wca1_s_wca1_s299_wca1_wca1_csa35" target="pr_16eadab6-1b1e-4210-9d02-e4ca08d5048f_p1"> <start x="13776.5" y="968.5"/> <end x="14475.0" y="492.5"/> </arc> <arc class="consumption" id="cons_996ce0ef-8f68-4180-94dd-210a90b52e90" source="wca1_s_wca1_s656_wca1_wca1_csa34" target="pr_319e970c-086e-423f-b630-e2e71af4b5a1_p1"> <start x="13412.25" y="910.5"/> <next x="13289.25" y="804.0"/> <end x="13101.577" y="610.25"/> </arc> <arc class="consumption" id="cons_d9cd2b33-a499-4beb-8b2c-c2c4ff10abb2" source="wca1_s_wca1_s289_wca1_wca1_sa211" target="pr_319e970c-086e-423f-b630-e2e71af4b5a1_p1"> <start x="13222.0" y="1145.0"/> <next x="13289.25" y="804.0"/> <end x="13101.577" y="610.25"/> </arc> <arc class="production" id="prod_621fbcca-a3b3-427f-9d38-80c74e72041a" source="pr_319e970c-086e-423f-b630-e2e71af4b5a1_p2" target="wca1_s_wca1_s1702_wca1_wca1_csa12"> <start x="13101.577" y="580.25"/> <end x="12917.5" y="390.5"/> </arc> <arc class="consumption" id="addreact_a75ae39c-c90a-49a9-a59f-41a61ed0db28" source="wca1_s_wca1_s970_wca1_wca1_sa574" target="pr_319e970c-086e-423f-b630-e2e71af4b5a1_p1"> <start x="14904.0" y="799.0"/> <end x="13101.577" y="610.25"/> </arc> <arc class="consumption" id="cons_f8e0cf6e-ff84-4c44-b94c-0ed985d88748" source="wca1_s_wca1_s1728_wca1_wca1_csa32" target="pr_25eb4521-af1f-4669-8775-11b9f7fe4268_p1"> <start x="14334.5" y="802.0"/> <end x="14333.0" y="801.0"/> </arc> <arc class="production" id="prod_fe752197-235e-4309-aee3-f92bcbbb6d1b" source="pr_25eb4521-af1f-4669-8775-11b9f7fe4268_p2" target="wca1_s_wca1_s1741_wca1_wca1_csa36"> <start x="14363.0" y="801.0"/> <end x="14361.5" y="800.0"/> </arc> <arc class="catalysis" id="modif_2d9d1891-209c-4daf-abc0-9e083eeb3ca4" source="wca1_s_wca1_s1690_wca1_wca1_csa70" target="pr_25eb4521-af1f-4669-8775-11b9f7fe4268"> <start x="14593.0" y="530.0"/> <end x="14347.631" y="796.0137"/> </arc> <arc class="consumption" id="cons_fafa88c4-c873-4b05-80c6-3b19d61b2e8b" source="wca1_s_wca1_s1741_wca1_wca1_csa36" target="pr_de6c1d53-e695-4b61-a3ce-d86a6015a332_p1"> <start x="14606.5" y="952.5"/> <end x="14604.25" y="962.25"/> </arc> <arc class="production" id="prod_9f7b0258-8413-4d24-bc9a-f25e6b039a58" source="pr_de6c1d53-e695-4b61-a3ce-d86a6015a332_p2" target="wca1_s_wca1_s1771_wca1_wca1_csa37"> <start x="14604.25" y="992.25"/> <end x="14602.0" y="1002.0"/> </arc> <arc class="catalysis" id="modif_5b71b67d-b835-4662-ba79-c3ab5da75f7c" source="wca1_s_wca1_s988_wca1_wca1_csa62" target="pr_de6c1d53-e695-4b61-a3ce-d86a6015a332"> <start x="15031.0" y="1037.75"/> <end x="14609.2295" y="977.7027"/> </arc> <arc class="consumption" id="addreact_c91912fe-f653-496c-9d9f-0378ff3a67a9" source="wca1_s_wca1_s299_wca1_wca1_csa35" target="pr_de6c1d53-e695-4b61-a3ce-d86a6015a332_p1"> <start x="13776.5" y="968.5"/> <end x="14604.25" y="962.25"/> </arc> <arc class="consumption" id="cons_011f9cee-63af-44be-a10b-151882baef34" source="wca1_s_wca1_s1771_wca1_wca1_csa37" target="pr_c93e1397-17c9-4262-8af9-c37b058c5048_p1"> <start x="14349.5" y="1172.0"/> <end x="14348.5" y="1172.75"/> </arc> <arc class="production" id="prod_62164532-ce91-45ae-b316-eb429ae370be" source="pr_c93e1397-17c9-4262-8af9-c37b058c5048_p2" target="wca1_s_wca1_s1754_wca1_wca1_csa38"> <start x="14318.5" y="1172.75"/> <end x="14317.5" y="1173.5"/> </arc> <arc class="consumption" id="cons_5be85ab1-ffff-4e44-8154-7db94a2c070b" source="wca1_s_wca1_s405_wca1_wca1_sa300" target="pr_d9ba20da-1465-4480-ac60-2c33a8da943c_p1"> <start x="13468.0" y="1136.0"/> <next x="13462.0" y="1092.75"/> <end x="13435.576" y="1073.625"/> </arc> <arc class="consumption" id="cons_f0f927b9-da78-4206-bfd4-79e2fe8f2b71" source="wca1_s_wca1_s406_wca1_wca1_sa301" target="pr_d9ba20da-1465-4480-ac60-2c33a8da943c_p1"> <start x="13608.0" y="1136.0"/> <next x="13462.0" y="1092.75"/> <end x="13435.576" y="1073.625"/> </arc> <arc class="production" id="prod_cf894071-dd98-4883-afcc-ff8ed1817157" source="pr_d9ba20da-1465-4480-ac60-2c33a8da943c_p2" target="wca1_s_wca1_s656_wca1_wca1_csa34"> <start x="13435.576" y="1043.625"/> <end x="13412.25" y="1028.5"/> </arc> <arc class="consumption" id="addreact_691900e8-1d09-497f-a9d9-1f5302387736" source="wca1_s_wca1_s490_wca1_wca1_sa63" target="pr_d9ba20da-1465-4480-ac60-2c33a8da943c_p1"> <start x="12991.25" y="484.5"/> <end x="13435.576" y="1073.625"/> </arc> <arc class="consumption" id="cons_31f198d0-9420-40b3-95a6-290ea8640fbb" source="wca1_s_wca1_s1754_wca1_wca1_csa38" target="pr_c934cad9-0557-4913-bfde-6379325a0154_p1"> <start x="14077.5" y="1346.0"/> <end x="14082.0" y="1452.0"/> </arc> <arc class="production" id="prod_24d94354-9abd-4245-a6c9-f50a97214d6e" source="pr_c934cad9-0557-4913-bfde-6379325a0154_p2" target="wca1_s_wca1_s1788_wca1_wca1_csa40"> <start x="14082.0" y="1482.0"/> <end x="14086.5" y="1588.0"/> </arc> <arc class="catalysis" id="modif_904e9f42-2b2a-48a2-b232-5e62629b50cd" source="wca1_s_wca1_s1754_wca1_wca1_csa38" target="pr_c934cad9-0557-4913-bfde-6379325a0154"> <start x="14317.5" y="1259.75"/> <next x="14274.999" y="1259.7491"/> <next x="14274.994" y="1466.8182"/> <end x="14086.996" y="1466.8142"/> </arc> <arc class="consumption" id="cons_24c7598f-5547-4f6a-9f9d-a414e1b1bcf9" source="wca1_s_wca1_s1788_wca1_wca1_csa40" target="pr_376c2f21-6219-4994-abaf-a58829b76e4b_p1"> <start x="14346.5" y="1765.0"/> <end x="14356.5" y="1764.75"/> </arc> <arc class="production" id="prod_2dc4b5c6-c462-4ad3-8f2d-583175f1e931" source="pr_376c2f21-6219-4994-abaf-a58829b76e4b_p2" target="wca1_s_wca1_s1805_wca1_wca1_csa41"> <start x="14386.5" y="1764.75"/> <end x="14396.5" y="1764.5"/> </arc> <arc class="catalysis" id="modif_03805c5d-1de7-422e-95ea-06ff62bc5c47" source="wca1_s_wca1_s1788_wca1_wca1_csa40" target="pr_376c2f21-6219-4994-abaf-a58829b76e4b"> <start x="14346.5" y="1676.5"/> <next x="14371.453" y="1676.5007"/> <end x="14371.45" y="1759.7502"/> </arc> <arc class="consumption" id="cons_8bde9152-2abd-469f-b9fd-e90e581e04d1" source="wca1_s_wca1_s1805_wca1_wca1_csa41" target="pr_b4b35622-3b80-413c-b73f-f087b66b9450_p1"> <start x="14655.0" y="1943.0"/> <end x="14657.174" y="1984.75"/> </arc> <arc class="production" id="prod_bb6756de-8987-4ffd-8358-5ac9b1c52929" source="pr_b4b35622-3b80-413c-b73f-f087b66b9450_p2" target="wca1_s_wca1_s486_wca1_wca1_csa43"> <start x="14657.174" y="2014.75"/> <next x="14659.347" y="2056.5"/> <end x="14774.0" y="2046.0"/> </arc> <arc class="production" id="prod_1ed9f13f-b55b-4c86-b334-624272e5aa8a" source="pr_b4b35622-3b80-413c-b73f-f087b66b9450_p2" target="wca1_s_wca1_s483_wca1_wca1_sa382"> <start x="14657.174" y="2014.75"/> <next x="14659.347" y="2056.5"/> <end x="14890.0" y="2431.0"/> </arc> <arc class="production" id="addprod_e06def43-bed8-4b9b-9d56-96928a2f8a75" source="pr_b4b35622-3b80-413c-b73f-f087b66b9450_p2" target="wca1_s_wca1_s1822_wca1_wca1_csa42"> <start x="14657.174" y="2014.75"/> <end x="14548.5" y="2105.5"/> </arc> <arc class="consumption" id="cons_8b50a21c-57e1-4516-8a11-390ae195fa8a" source="wca1_s_wca1_s1822_wca1_wca1_csa42" target="pr_adea9836-ac39-4c0e-a32d-20821e626a05_p1"> <start x="14293.5" y="2256.0"/> <end x="14290.132" y="2267.25"/> </arc> <arc class="production" id="prod_cb6bc104-eed4-4c9c-822b-69ebd55e878c" source="pr_adea9836-ac39-4c0e-a32d-20821e626a05_p2" target="wca1_s_wca1_s1836_wca1_wca1_csa44"> <start x="14290.132" y="2297.25"/> <next x="14286.764" y="2308.5"/> <end x="13968.375" y="2353.0"/> </arc> <arc class="production" id="prod_6e5bc850-b3f8-4c87-9379-1ef13005e99d" source="pr_adea9836-ac39-4c0e-a32d-20821e626a05_p2" target="wca1_s_wca1_s673_wca1_wca1_csa45"> <start x="14290.132" y="2297.25"/> <next x="14286.764" y="2308.5"/> <end x="14690.5" y="2428.0"/> </arc> <arc class="consumption" id="cons_29b622a0-689e-4455-a31c-aeed2cb67846" source="wca1_s_wca1_s1702_wca1_wca1_csa12" target="pr_53ea2870-09b3-4780-8dce-34711301735d_p1"> <start x="12821.5" y="309.0"/> <end x="12821.875" y="308.5"/> </arc> <arc class="production" id="prod_318535a5-1dcb-409f-9a36-7572a3627c5c" source="pr_53ea2870-09b3-4780-8dce-34711301735d_p2" target="wca1_s_wca1_s1704_wca1_wca1_csa13"> <start x="12791.875" y="308.5"/> <end x="12792.25" y="308.0"/> </arc> <arc class="consumption" id="cons_64620695-54e7-4c77-8a36-af2e3ef04033" source="wca1_s_wca1_s1187_wca1_wca1_csa63" target="pr_4d4241f8-eec1-48ee-9a8c-f594c5e74b33_p1"> <start x="13745.0" y="742.0"/> <next x="13543.0" y="969.0"/> <end x="13550.75" y="968.7259"/> </arc> <arc class="consumption" id="cons_0f7a43a8-baef-4a05-ac50-81ff9eba1599" source="wca1_s_wca1_s656_wca1_wca1_csa34" target="pr_4d4241f8-eec1-48ee-9a8c-f594c5e74b33_p1"> <start x="13510.25" y="969.5"/> <next x="13543.0" y="969.0"/> <end x="13550.75" y="968.7259"/> </arc> <arc class="production" id="prod_27c94400-834e-4e79-a41c-563ca55fdafc" source="pr_4d4241f8-eec1-48ee-9a8c-f594c5e74b33_p2" target="wca1_s_wca1_s299_wca1_wca1_csa35"> <start x="13580.75" y="968.7259"/> <end x="13584.5" y="968.5"/> </arc> <arc class="consumption" id="addreact_fb3ede2c-d999-4e56-b9df-b72cc4395651" source="wca1_s_wca1_s886_wca1_wca1_sa553" target="pr_4d4241f8-eec1-48ee-9a8c-f594c5e74b33_p1"> <start x="13506.0" y="759.0"/> <end x="13550.75" y="968.7259"/> </arc> <arc class="consumption" id="cons_1a069ab6-0a60-4615-8e80-b54f3f149100" source="wca1_s_wca1_s163_wca1_wca1_sa131" target="pr_590515a1-77d7-47ec-9fc7-01c044ec89db_p1"> <start x="12878.0" y="2263.0"/> <next x="12893.9375" y="2203.6667"/> <end x="12949.969" y="2178.6284"/> </arc> <arc class="consumption" id="cons_d4344c36-8997-4b64-8a6e-4db7df641d01" source="wca1_s_wca1_s162_wca1_wca1_sa130" target="pr_590515a1-77d7-47ec-9fc7-01c044ec89db_p1"> <start x="12877.875" y="2203.6667"/> <next x="12893.9375" y="2203.6667"/> <end x="12949.969" y="2178.6284"/> </arc> <arc class="production" id="prod_1d04d159-a7dd-4325-bf73-08c22bf82f05" source="pr_590515a1-77d7-47ec-9fc7-01c044ec89db_p2" target="wca1_s_wca1_s1720_wca1_wca1_csa46"> <start x="12979.969" y="2178.6284"/> <end x="13032.0" y="2155.0"/> </arc> <arc class="consumption" id="addreact_761e6a85-56f7-4ccb-bfd9-2c42d9491839" source="wca1_s_wca1_s562_wca1_wca1_sa435" target="pr_590515a1-77d7-47ec-9fc7-01c044ec89db_p1"> <start x="12878.0" y="2144.3333"/> <end x="12949.969" y="2178.6284"/> </arc> <arc class="consumption" id="addreact_ea9c8387-452b-400c-a197-b9a278cea27c" source="wca1_s_wca1_s1717_wca1_wca1_csa22" target="pr_590515a1-77d7-47ec-9fc7-01c044ec89db_p1"> <start x="12926.0" y="2046.0"/> <end x="12949.969" y="2178.6284"/> </arc> <arc class="consumption" id="addreact_82bf0c70-9a5c-4b97-bba4-42a7641a0857" source="wca1_s_wca1_s783_wca1_wca1_sa545" target="pr_590515a1-77d7-47ec-9fc7-01c044ec89db_p1"> <start x="12956.0" y="2247.0"/> <end x="12949.969" y="2178.6284"/> </arc> <arc class="consumption" id="cons_b26950d3-35af-49fa-bbce-de7ddbb66a80" source="wca1_s_wca1_s1716_wca1_wca1_csa11" target="pr_1d3fff2d-b8e1-41f9-8d51-8997174ef9ee_p1"> <start x="13227.667" y="2409.0"/> <next x="13271.583" y="2204.0"/> <end x="13281.541" y="2201.8257"/> </arc> <arc class="consumption" id="cons_e227d0ab-64bf-4e9d-91a7-05297b1179b7" source="wca1_s_wca1_s1720_wca1_wca1_csa46" target="pr_1d3fff2d-b8e1-41f9-8d51-8997174ef9ee_p1"> <start x="13244.0" y="2155.0"/> <next x="13271.583" y="2204.0"/> <end x="13281.541" y="2201.8257"/> </arc> <arc class="production" id="prod_c892112f-cb6e-48c7-a764-945bb33edfc1" source="pr_1d3fff2d-b8e1-41f9-8d51-8997174ef9ee_p2" target="wca1_s_wca1_s1718_wca1_wca1_csa23"> <start x="13311.541" y="2201.8257"/> <end x="13317.5" y="2200.0"/> </arc> <arc class="catalysis" id="modif_d8249905-e540-4f45-b0d8-f9c5849fd801" source="wca1_s_wca1_s1720_wca1_wca1_csa46" target="pr_1d3fff2d-b8e1-41f9-8d51-8997174ef9ee"> <start x="13244.0" y="2101.0"/> <end x="13296.107" y="2196.8445"/> </arc> <arc class="consumption" id="addreact_d113767c-a892-4c8a-80cf-109eb8a06b56" source="wca1_s_wca1_s1721_wca1_wca1_csa47" target="pr_1d3fff2d-b8e1-41f9-8d51-8997174ef9ee_p1"> <start x="12976.5" y="1960.0"/> <end x="13281.541" y="2201.8257"/> </arc> <arc class="consumption" id="cons_82edc4ec-35f4-4600-8f03-c684e6480993" source="wca1_s_wca1_s1718_wca1_wca1_csa23" target="pr_0d71267c-98c8-415c-afcd-b432c2f31362_p1"> <start x="13413.0" y="1876.5"/> <end x="13412.638" y="1886.25"/> </arc> <arc class="production" id="prod_5ec23299-9201-4b66-a406-f9521c3895c6" source="pr_0d71267c-98c8-415c-afcd-b432c2f31362_p2" target="wca1_s_wca1_s1725_wca1_wca1_csa51"> <start x="13412.638" y="1856.25"/> <next x="13412.275" y="1866.0"/> <end x="13411.0" y="1822.0"/> </arc> <arc class="production" id="prod_2bb1c871-2519-45c4-8e41-86b7004345d0" source="pr_0d71267c-98c8-415c-afcd-b432c2f31362_p2" target="wca1_s_wca1_s604_wca1_wca1_csa50"> <start x="13412.638" y="1856.25"/> <next x="13412.275" y="1866.0"/> <end x="13582.0" y="1726.0"/> </arc> <arc class="production" id="addprod_7baff347-d5a3-4162-ad69-85325b7c1f79" source="pr_0d71267c-98c8-415c-afcd-b432c2f31362_p2" target="wca1_s_wca1_s654_wca1_wca1_sa492"> <start x="13412.638" y="1856.25"/> <end x="13206.25" y="1655.0"/> </arc> <arc class="consumption" id="cons_be1f7b8c-d22e-4e6c-af2d-bf0b9ed860ca" source="wca1_s_wca1_s189_wca1_wca1_sa152" target="pr_7f88b79c-9cd5-4adf-8a26-ec816ecbba18_p1"> <start x="13313.0" y="601.0"/> <next x="12940.0" y="827.0"/> <end x="12867.754" y="894.75"/> </arc> <arc class="consumption" id="cons_f917e941-aac5-470d-b7d3-9771bb07cb41" source="wca1_s_wca1_s725_wca1_wca1_csa52" target="pr_7f88b79c-9cd5-4adf-8a26-ec816ecbba18_p1"> <start x="12864.25" y="824.5"/> <next x="12940.0" y="827.0"/> <end x="12867.754" y="894.75"/> </arc> <arc class="production" id="prod_8df8831f-e7b3-4a61-b3f6-d1cd606b17d3" source="pr_7f88b79c-9cd5-4adf-8a26-ec816ecbba18_p2" target="wca1_s_wca1_s731_wca1_wca1_csa53"> <start x="12867.754" y="924.75"/> <end x="12799.0" y="988.5"/> </arc> <arc class="catalysis" id="modif_3b0dd28f-1bd4-4a69-8f25-69a3d69229fa" source="wca1_s_wca1_s181_wca1_wca1_csa26" target="pr_7f88b79c-9cd5-4adf-8a26-ec816ecbba18"> <start x="14004.5" y="339.5"/> <end x="12871.5205" y="913.0384"/> </arc> <arc class="consumption" id="cons_cecc7277-aec6-408d-af4f-fa3681329aa0" source="wca1_s_wca1_s189_wca1_wca1_sa152" target="pr_a6b36ad8-67c0-413d-9e1f-edcb93a60a5c_p1"> <start x="13313.0" y="601.0"/> <next x="12759.0" y="1243.0"/> <end x="12759.643" y="1237.0"/> </arc> <arc class="consumption" id="cons_01c864fc-c953-4c55-9d5b-fcb062c5806f" source="wca1_s_wca1_s733_wca1_wca1_sa531" target="pr_a6b36ad8-67c0-413d-9e1f-edcb93a60a5c_p1"> <start x="12759.0" y="1223.0"/> <next x="12759.0" y="1243.0"/> <end x="12759.643" y="1237.0"/> </arc> <arc class="production" id="prod_3c5ec092-7078-4395-962c-a20a427ca476" source="pr_a6b36ad8-67c0-413d-9e1f-edcb93a60a5c_p2" target="wca1_s_wca1_s752_wca1_wca1_csa54"> <start x="12759.643" y="1267.0"/> <end x="12760.0" y="1257.0"/> </arc> <arc class="consumption" id="cons_71082d20-61b8-4b7c-a62c-b911455cfc23" source="wca1_s_wca1_s752_wca1_wca1_csa54" target="pr_053cc335-7aac-452f-a054-ff714683dca8_p1"> <start x="12785.0" y="1257.0"/> <end x="12938.25" y="755.0"/> </arc> <arc class="production" id="prod_62c20dfa-65c3-4e17-ba56-748567ae25bb" source="pr_053cc335-7aac-452f-a054-ff714683dca8_p2" target="wca1_s_wca1_s753_wca1_wca1_csa55"> <start x="12938.25" y="725.0"/> <end x="13091.5" y="223.0"/> </arc> <arc class="stimulation" id="modif_23b22a7c-35b5-46c7-a748-e94c11d55c9f" source="wca1_s_wca1_s1341_wca1_wca1_csa65" target="pr_053cc335-7aac-452f-a054-ff714683dca8"> <start x="12981.0" y="1006.0"/> <end x="12943.044" y="741.421"/> </arc> <arc class="consumption" id="cons_4b878226-2986-4785-9590-270669e77fac" source="wca1_s_wca1_s1_wca1_wca1_sa1" target="pr_22d3a885-7a9f-45d2-bba4-099c37660441_p1"> <start x="12767.0" y="719.5"/> <next x="13108.0" y="1038.0"/> <end x="13115.5" y="1038.0"/> </arc> <arc class="consumption" id="cons_d64e48a6-7402-4e14-b4fd-30e01f29855c" source="wca1_s_wca1_s757_wca1_wca1_sa537" target="pr_22d3a885-7a9f-45d2-bba4-099c37660441_p1"> <start x="13072.0" y="1104.0"/> <next x="13108.0" y="1038.0"/> <end x="13115.5" y="1038.0"/> </arc> <arc class="production" id="prod_220c4d72-2b40-41fb-8f69-47c9e8053b28" source="pr_22d3a885-7a9f-45d2-bba4-099c37660441_p2" target="wca1_s_wca1_s758_wca1_wca1_csa56"> <start x="13145.5" y="1038.0"/> <end x="13149.0" y="1038.0"/> </arc> <arc class="consumption" id="cons_1719adb7-7d88-464b-b411-d92642b980f2" source="wca1_s_wca1_s758_wca1_wca1_csa56" target="pr_9c92ceb4-27c4-4fe7-be0c-3d234e0fc889_p1"> <start x="13174.0" y="978.0"/> <end x="13186.25" y="616.0"/> </arc> <arc class="production" id="prod_3935b090-c99c-46cb-aec6-3863f496b33b" source="pr_9c92ceb4-27c4-4fe7-be0c-3d234e0fc889_p2" target="wca1_s_wca1_s761_wca1_wca1_csa57"> <start x="13186.25" y="586.0"/> <end x="13198.5" y="224.0"/> </arc> <arc class="stimulation" id="modif_38d170af-e217-4c6b-be5c-7e355b545222" source="wca1_s_wca1_s1341_wca1_wca1_csa65" target="pr_9c92ceb4-27c4-4fe7-be0c-3d234e0fc889"> <start x="13081.0" y="1006.0"/> <end x="13181.09" y="605.83496"/> </arc> <arc class="catalysis" id="modif_cdd970f5-9892-451a-bc8e-032f84d51fe7" source="wca1_s_wca1_s181_wca1_wca1_csa26" target="pr_9c92ceb4-27c4-4fe7-be0c-3d234e0fc889"> <start x="14004.5" y="339.5"/> <end x="13191.247" y="601.16235"/> </arc> <arc class="consumption" id="cons_c6170335-cd9f-4a22-9469-13f29ac34a72" source="wca1_s_wca1_s761_wca1_wca1_csa57" target="pr_75d2edfe-2070-4a4a-9170-a637657e11c0_p1"> <start x="13248.5" y="224.0"/> <end x="13145.25" y="688.0"/> </arc> <arc class="production" id="prod_e61e6553-43ab-4ae6-bf94-f26077b5156b" source="pr_75d2edfe-2070-4a4a-9170-a637657e11c0_p2" target="wca1_s_wca1_s764_wca1_wca1_csa58"> <start x="13145.25" y="718.0"/> <end x="13042.0" y="1182.0"/> </arc> <arc class="stimulation" id="modif_27802603-b867-4158-9e64-940f8fd43ea3" source="wca1_s_wca1_s767_wca1_wca1_sa544" target="pr_75d2edfe-2070-4a4a-9170-a637657e11c0"> <start x="12911.0" y="702.0"/> <end x="13139.309" y="706.83417"/> </arc> <arc class="catalysis" id="modif_1b52fab5-5ca0-461e-9175-1951e6591a66" source="wca1_s_wca1_s181_wca1_wca1_csa26" target="pr_75d2edfe-2070-4a4a-9170-a637657e11c0"> <start x="14004.5" y="339.5"/> <end x="13150.138" y="704.0536"/> </arc> <arc class="consumption" id="cons_8555c8ed-35e5-4221-8441-2fd0dd3d5ab2" source="wca1_s_wca1_s231_wca1_wca1_sa183" target="pr_0794e9b6-9527-4a59-949e-eb4f53a0c34c_p1"> <start x="15068.0" y="724.5"/> <next x="15069.0" y="748.0"/> <end x="15067.558" y="748.0"/> </arc> <arc class="consumption" id="cons_ad54a89a-3dcf-4fc9-8cf8-9cce2c1197b6" source="wca1_s_wca1_s970_wca1_wca1_sa574" target="pr_0794e9b6-9527-4a59-949e-eb4f53a0c34c_p1"> <start x="14984.0" y="799.0"/> <next x="15069.0" y="748.0"/> <end x="15067.558" y="748.0"/> </arc> <arc class="production" id="prod_50cd2fd7-934a-4a8a-9894-f64a55e5218f" source="pr_0794e9b6-9527-4a59-949e-eb4f53a0c34c_p2" target="wca1_s_wca1_s973_wca1_wca1_csa60"> <start x="15067.558" y="778.0"/> <end x="15066.5" y="774.0"/> </arc> <arc class="consumption" id="cons_869b718f-3c99-43a3-846c-b1e52d2a0611" source="wca1_s_wca1_s266_wca1_wca1_sa200" target="pr_3271cbef-f78a-43a6-b83b-7cf71f77363a_p1"> <start x="14989.0" y="889.0"/> <next x="15065.0" y="881.5"/> <end x="15068.3" y="888.5"/> </arc> <arc class="consumption" id="cons_cfd27dbc-e6ab-41f2-bc9a-8c00583fac9e" source="wca1_s_wca1_s973_wca1_wca1_csa60" target="pr_3271cbef-f78a-43a6-b83b-7cf71f77363a_p1"> <start x="15066.5" y="866.0"/> <next x="15065.0" y="881.5"/> <end x="15068.3" y="888.5"/> </arc> <arc class="production" id="prod_2f6dbc92-8fa2-4b41-a850-ed1462202f17" source="pr_3271cbef-f78a-43a6-b83b-7cf71f77363a_p2" target="wca1_s_wca1_s988_wca1_wca1_csa62"> <start x="15068.3" y="918.5"/> <end x="15071.0" y="921.5"/> </arc> <arc class="consumption" id="cons_7d5b85af-0b18-4087-9c55-267a52ad8dbe" source="wca1_s_wca1_s1836_wca1_wca1_csa44" target="pr_66398852-d58b-4856-8545-ab9953ba9684_p1"> <start x="13968.375" y="2554.5"/> <end x="14056.709" y="2641.75"/> </arc> <arc class="production" id="prod_8be35605-3b5d-4c81-83bd-e9601e322fbe" source="pr_66398852-d58b-4856-8545-ab9953ba9684_p2" target="wca1_s_wca1_s1036_wca1_wca1_sa600"> <start x="14056.709" y="2671.75"/> <end x="14145.042" y="2759.0"/> </arc> <arc class="consumption" id="cons_842789c3-5f8d-4716-b258-1fdb64f88e21" source="wca1_s_wca1_s1836_wca1_wca1_csa44" target="pr_dcd6f625-e402-43bf-bf04-da0f87a64d6d_p1"> <start x="13968.375" y="2554.5"/> <end x="14088.291" y="2656.75"/> </arc> <arc class="production" id="prod_1e9df2ad-03df-4984-b74a-2f66a579c512" source="pr_dcd6f625-e402-43bf-bf04-da0f87a64d6d_p2" target="wca1_s_wca1_s1037_wca1_wca1_sa601"> <start x="14118.291" y="2656.75"/> <end x="14238.208" y="2759.0"/> </arc> <arc class="consumption" id="cons_4536f5fa-d82b-438a-a460-a7ff81f55270" source="wca1_s_wca1_s673_wca1_wca1_csa45" target="pr_2f22eba9-085a-431b-a4b9-981646823964_p1"> <start x="14690.5" y="2568.0"/> <end x="14458.637" y="2663.5"/> </arc> <arc class="production" id="prod_c1b57a30-c769-42f3-b0be-2c7f738125b2" source="pr_2f22eba9-085a-431b-a4b9-981646823964_p2" target="wca1_s_wca1_s1036_wca1_wca1_sa600"> <start x="14428.637" y="2663.5"/> <end x="14196.774" y="2759.0"/> </arc> <arc class="consumption" id="cons_52e42274-ca03-477d-92a1-bdd3df5a01ac" source="wca1_s_wca1_s673_wca1_wca1_csa45" target="pr_f74d9907-5595-44ce-be64-bbd1af28eb4d_p1"> <start x="14690.5" y="2568.0"/> <end x="14504.996" y="2663.5"/> </arc> <arc class="production" id="prod_1c434d27-1cde-484c-9612-810c9dcd8986" source="pr_f74d9907-5595-44ce-be64-bbd1af28eb4d_p2" target="wca1_s_wca1_s1037_wca1_wca1_sa601"> <start x="14474.996" y="2663.5"/> <end x="14289.493" y="2759.0"/> </arc> <arc class="consumption" id="cons_520475d7-41a4-4bb2-880f-aea3862608f8" source="wca1_s_wca1_s483_wca1_wca1_sa382" target="pr_6e6cdde9-186a-40a2-a25b-e3ca4caef0e6_p1"> <start x="14890.0" y="2554.0"/> <end x="14559.0" y="2657.989"/> </arc> <arc class="production" id="prod_b89aefee-8809-4155-9f99-4cefbc73b9b4" source="pr_6e6cdde9-186a-40a2-a25b-e3ca4caef0e6_p2" target="wca1_s_wca1_s1036_wca1_wca1_sa600"> <start x="14529.0" y="2657.989"/> <end x="14198.0" y="2761.978"/> </arc> <arc class="consumption" id="cons_7a015d5b-15d5-415d-a412-c960d5147fef" source="wca1_s_wca1_s483_wca1_wca1_sa382" target="pr_500c5892-57b5-4da1-a765-1ffa732365af_p1"> <start x="14890.0" y="2554.0"/> <end x="14609.0" y="2657.038"/> </arc> <arc class="production" id="prod_dae4cbc8-c6a7-4b14-9c91-591926125476" source="pr_500c5892-57b5-4da1-a765-1ffa732365af_p2" target="wca1_s_wca1_s1037_wca1_wca1_sa601"> <start x="14579.0" y="2657.038"/> <end x="14298.0" y="2760.076"/> </arc> <arc class="consumption" id="cons_084e3d76-09a4-487b-8a01-9849083dfb5c" source="wca1_s_wca1_s1187_wca1_wca1_csa63" target="pr_0473c986-ee98-41a0-9514-54d3688fec8e_p1"> <start x="13745.0" y="742.0"/> <end x="13738.0" y="766.5"/> </arc> <arc class="production" id="prod_69e552dd-4489-4e4a-a0da-d06e38429d31" source="pr_0473c986-ee98-41a0-9514-54d3688fec8e_p2" target="wca1_s_wca1_s1188_wca1_wca1_csa64"> <start x="13738.0" y="796.5"/> <end x="13731.0" y="821.0"/> </arc> <arc class="catalysis" id="modif_dcf95c3a-d2b8-405b-aa9c-ec3b46c97fef" source="wca1_s_wca1_s1192_wca1_wca1_sa626" target="pr_0473c986-ee98-41a0-9514-54d3688fec8e"> <start x="13618.0" y="856.0"/> <end x="13733.077" y="780.6275"/> </arc> <arc class="production" id="addprod_c4dc3c76-9c25-4efc-b74d-e647411544f5" source="pr_0473c986-ee98-41a0-9514-54d3688fec8e_p2" target="wca1_s_wca1_s1191_wca1_wca1_sa625"> <start x="13738.0" y="796.5"/> <end x="13775.5" y="795.15173"/> </arc> <arc class="consumption" id="cons_5e0babe3-0ec3-49fa-bd2a-d6de748e848c" source="wca1_s_wca1_s1849_wca1_wca1_sa650" target="pr_17f1f7ed-8a8b-47ec-a5e5-a7540591054a_p1"> <start x="13965.0" y="448.0"/> <end x="13991.5" y="448.0"/> </arc> <arc class="production" id="prod_81cea699-fca4-4cc6-ac9f-94c1c29a79e8" source="pr_17f1f7ed-8a8b-47ec-a5e5-a7540591054a_p2" target="wca1_s_wca1_s1849_wca1_wca1_sa651"> <start x="14021.5" y="448.0"/> <end x="14048.0" y="448.0"/> </arc> <arc class="catalysis" id="modif_1a11a720-9678-4dc1-8a5a-5ddab639d2a5" source="wca1_s_wca1_s181_wca1_wca1_csa26" target="pr_17f1f7ed-8a8b-47ec-a5e5-a7540591054a"> <start x="14004.5" y="339.5"/> <end x="14006.5" y="443.0"/> </arc> <arc class="consumption" id="cons_30109c5e-0418-4b4e-bce4-b9915d4fe6e1" source="wca1_s_wca1_s1392_wca1_wca1_sa653" target="pr_2ad8ce53-f7f7-4a0c-adb4-ee86320e1bfa_p1"> <start x="14104.5" y="480.0"/> <end x="14104.5" y="463.0"/> </arc> <arc class="production" id="prod_c932ab00-4852-43a9-948d-2198fdd52502" source="pr_2ad8ce53-f7f7-4a0c-adb4-ee86320e1bfa_p2" target="wca1_s_wca1_s1654_wca1_wca1_sa652"> <start x="14104.5" y="433.0"/> <end x="14104.5" y="416.0"/> </arc> <arc class="catalysis" id="modif_092b3635-ad53-4379-adc3-e5552a1a5733" source="wca1_s_wca1_s1849_wca1_wca1_sa651" target="pr_2ad8ce53-f7f7-4a0c-adb4-ee86320e1bfa"> <start x="14088.0" y="468.0"/> <end x="14099.5" y="448.0"/> </arc> <arc class="consumption" id="cons_9eafcc8d-7f8e-4be1-b2dd-4deb97c9ee88" source="wca1_s_wca1_s1836_wca1_wca1_csa44" target="pr_bd2b32ed-81c1-4f59-8059-0a2343065c6c_p1"> <start x="14138.0" y="2453.75"/> <end x="14135.805" y="2456.0205"/> </arc> <arc class="production" id="prod_a08d9bf9-600b-429c-9c69-9ca87b321728" source="pr_bd2b32ed-81c1-4f59-8059-0a2343065c6c_p2" target="wca1_s_wca1_s1536_wca1_wca1_sa665"> <start x="14165.805" y="2456.0205"/> <next x="14163.609" y="2458.2908"/> <end x="14174.125" y="2596.25"/> </arc> <arc class="production" id="prod_4d534912-a360-471d-9887-a0e287b3d1e1" source="pr_bd2b32ed-81c1-4f59-8059-0a2343065c6c_p2" target="wca1_s_wca1_s1843_wca1_wca1_csa68"> <start x="14165.805" y="2456.0205"/> <next x="14163.609" y="2458.2908"/> <end x="14206.875" y="2461.5"/> </arc> <arc class="consumption" id="cons_7de9bee6-28a4-467b-b9a5-02a032b33374" source="wca1_s_wca1_s1370_wca1_wca1_sa648" target="pr_20df6b23-8e37-4f02-880c-72cc833abfd7_p1"> <start x="13462.5" y="411.0"/> <end x="13489.671" y="440.5"/> </arc> <arc class="production" id="prod_ac2967b9-b7b7-4d68-a57d-bfdabead98db" source="pr_20df6b23-8e37-4f02-880c-72cc833abfd7_p2" target="wca1_s_wca1_s1537_wca1_wca1_sa684"> <start x="13489.671" y="470.5"/> <end x="13516.842" y="500.0"/> </arc> <arc class="consumption" id="cons_9014e1b6-5977-4943-96b5-565d57d5d81c" source="wca1_s_wca1_s1651_wca1_wca1_csa69" target="pr_fb95432b-cc3a-4d33-b2d6-8192f63d22bc_p1"> <start x="13342.0" y="1261.0"/> <end x="13299.0" y="1261.0"/> </arc> <arc class="production" id="prod_eaf62c85-cd02-43cf-aa0a-b715a177f704" source="pr_fb95432b-cc3a-4d33-b2d6-8192f63d22bc_p2" target="wca1_s_wca1_s289_wca1_wca1_sa211"> <start x="13269.0" y="1261.0"/> <next x="13226.0" y="1261.0"/> <end x="13222.0" y="1185.0"/> </arc> <arc class="production" id="prod_665d5e60-ca62-4d30-888c-0c8e8d497d93" source="pr_fb95432b-cc3a-4d33-b2d6-8192f63d22bc_p2" target="wca1_s_wca1_s1653_wca1_wca1_sa690"> <start x="13269.0" y="1261.0"/> <next x="13226.0" y="1261.0"/> <end x="13222.0" y="1275.0"/> </arc> <arc class="catalysis" id="modif_672f98d4-60c0-4a85-8bd0-afc5f1b838aa" source="wca1_s_wca1_s973_wca1_wca1_csa60" target="pr_fb95432b-cc3a-4d33-b2d6-8192f63d22bc"> <start x="15066.5" y="866.0"/> <end x="13284.0" y="1256.0"/> </arc> <arc class="stimulation" id="direct_3f2e0d0e-6b96-4a29-b70d-b70fb9d8fe05" source="wca1_s_wca1_s1651_wca1_wca1_csa69" target="wca1_s_wca1_s1686_wca1_wca1_sa721"> <start x="13442.0" y="1261.0"/> <end x="13493.0" y="1261.0"/> </arc> <arc class="stimulation" id="direct_7d1a97b2-7f40-474a-926f-9ba7ded6b642" source="wca1_s_wca1_s1687_wca1_wca1_sa722" target="wca1_s_wca1_s973_wca1_wca1_csa60"> <start x="15182.0" y="819.37384"/> <end x="15115.0" y="820.0"/> </arc> <arc class="consumption" id="cons_dc002780-25d5-456c-93c3-6deac04ecf38" source="wca1_s_wca1_s1691_wca1_wca1_sa725" target="pr_08478277-d748-4084-b204-13edb01da731_p1"> <start x="14965.0" y="1244.0"/> <next x="15069.335" y="1243.072"/> <end x="15070.022" y="1260.536"/> </arc> <arc class="consumption" id="cons_9f243254-43cc-46f5-8ded-fd53b676bbbc" source="wca1_s_wca1_s1850_wca1_wca1_sa733" target="pr_08478277-d748-4084-b204-13edb01da731_p1"> <start x="15070.375" y="1172.0"/> <next x="15069.335" y="1243.072"/> <end x="15070.022" y="1260.536"/> </arc> <arc class="production" id="prod_4cf8c1a0-f3e0-484e-90ee-e213d76cc79d" source="pr_08478277-d748-4084-b204-13edb01da731_p2" target="wca1_s_wca1_s1696_wca1_wca1_csa71"> <start x="15070.022" y="1290.536"/> <end x="15070.625" y="1304.0"/> </arc> <arc class="stimulation" id="direct_13f5f7c2-f8a1-4b46-b4b3-bf788161d161" source="wca1_s_wca1_s1696_wca1_wca1_csa71" target="wca1_s_wca1_s1697_wca1_wca1_sa729"> <start x="15120.625" y="1364.0"/> <end x="15197.0" y="1362.6874"/> </arc> <arc class="consumption" id="cons_0a33e6d3-5b40-41d2-9940-68110415d724" source="wca1_s_wca1_s1698_wca1_wca1_sa730" target="pr_6325609a-96a5-430a-8e57-86d04374a906_p1"> <start x="13181.0" y="443.0"/> <next x="13312.5" y="504.0"/> <end x="13326.27" y="492.0"/> </arc> <arc class="consumption" id="cons_2ac45559-9014-4516-9941-50ee38629741" source="wca1_s_wca1_s189_wca1_wca1_sa152" target="pr_6325609a-96a5-430a-8e57-86d04374a906_p1"> <start x="13313.0" y="561.0"/> <next x="13312.5" y="504.0"/> <end x="13326.27" y="492.0"/> </arc> <arc class="production" id="prod_01ef4d16-2dc4-45a1-ba85-1d83811053dd" source="pr_6325609a-96a5-430a-8e57-86d04374a906_p2" target="wca1_s_wca1_s1699_wca1_wca1_csa72"> <start x="13326.27" y="462.0"/> <end x="13338.0" y="454.0"/> </arc> <arc class="consumption" id="cons_7cfa0293-ce3c-41d3-85c0-eb004dfd61c1" source="wca1_s_wca2_s3_wca1_wca2_sa3" target="pr_90dfc642-fc16-4ab6-9f03-9be49b2190a4_p1"> <start x="15774.0" y="919.86597"/> <next x="15705.0" y="811.0"/> <end x="15703.5" y="811.0"/> </arc> <arc class="consumption" id="cons_f2536524-1cfc-4b3f-ae3a-f17d7d095313" source="wca1_s_wca2_s1_wca1_wca2_sa1" target="pr_90dfc642-fc16-4ab6-9f03-9be49b2190a4_p1"> <start x="15724.0" y="781.0"/> <next x="15705.0" y="811.0"/> <end x="15703.5" y="811.0"/> </arc> <arc class="production" id="prod_026546df-4b97-47f4-bdf2-d4f678313d61" source="pr_90dfc642-fc16-4ab6-9f03-9be49b2190a4_p2" target="wca1_s_wca2_s5_wca1_wca2_csa1"> <start x="15673.5" y="811.0"/> <end x="15676.0" y="811.0"/> </arc> <arc class="consumption" id="cons_16da7f1e-8e10-43a5-baa9-7d962c1c36d6" source="wca1_s_wca2_s2_wca1_wca2_sa2" target="pr_e71f108c-6624-478a-b45a-eb028bad4299_p1"> <start x="15876.25" y="933.0"/> <next x="15810.0" y="811.0"/> <end x="15825.25" y="811.0"/> </arc> <arc class="consumption" id="cons_c3c2c6d8-7f4c-41eb-ae4f-d72cfc9bf1ec" source="wca1_s_wca2_s1_wca1_wca2_sa1" target="pr_e71f108c-6624-478a-b45a-eb028bad4299_p1"> <start x="15804.0" y="781.0"/> <next x="15810.0" y="811.0"/> <end x="15825.25" y="811.0"/> </arc> <arc class="production" id="prod_bc1623d8-acfc-4c96-ad8b-49906160e061" source="pr_e71f108c-6624-478a-b45a-eb028bad4299_p2" target="wca1_s_wca2_s8_wca1_wca2_csa2"> <start x="15855.25" y="811.0"/> <end x="15866.5" y="811.0"/> </arc> <arc class="consumption" id="cons_e2594a8e-830f-4c78-b347-e9a00d8751d9" source="wca1_s_wca2_s21_wca1_wca2_sa18" target="pr_831c5040-3920-439b-b595-7a511c4a8bb6_p1"> <start x="16992.0" y="1227.0"/> <end x="17028.0" y="1227.0"/> </arc> <arc class="production" id="prod_ab8a8860-2725-491a-aeef-d9a9069ef740" source="pr_831c5040-3920-439b-b595-7a511c4a8bb6_p2" target="wca1_s_wca2_s22_wca1_wca2_sa19"> <start x="17058.0" y="1227.0"/> <end x="17094.0" y="1227.0"/> </arc> <arc class="catalysis" id="modif_051e2f51-b1cd-4baa-b318-24c98fca00b0" source="wca1_s_wca2_s23_wca1_wca2_sa20" target="pr_831c5040-3920-439b-b595-7a511c4a8bb6"> <start x="17043.0" y="1155.0"/> <end x="17043.0" y="1222.0"/> </arc> <arc class="catalysis" id="modif_ac9730ec-bba4-428e-bdf1-9d036b636db9" source="wca1_s_wca2_s24_wca1_wca2_sa21" target="pr_831c5040-3920-439b-b595-7a511c4a8bb6"> <start x="17043.0" y="1303.0"/> <end x="17043.0" y="1232.0"/> </arc> <arc class="consumption" id="cons_a06839d4-c5f5-437e-b3d7-fad5a3181045" source="wca1_s_wca2_s22_wca1_wca2_sa19" target="pr_5216a645-ca8c-41c5-bb90-24f9986cd171_p1"> <start x="17174.0" y="1227.0"/> <end x="17215.5" y="1227.0"/> </arc> <arc class="production" id="prod_60bdc5be-1af4-4ea5-960c-d7d3fa824bd9" source="pr_5216a645-ca8c-41c5-bb90-24f9986cd171_p2" target="wca1_s_wca2_s25_wca1_wca2_sa22"> <start x="17245.5" y="1227.0"/> <end x="17287.0" y="1227.0"/> </arc> <arc class="catalysis" id="modif_a113f88a-e766-4cb6-947b-edb3d0e68cfc" source="wca1_s_wca2_s26_wca1_wca2_sa23" target="pr_5216a645-ca8c-41c5-bb90-24f9986cd171"> <start x="17229.5" y="1155.0"/> <end x="17230.5" y="1222.0"/> </arc> <arc class="consumption" id="cons_b0966358-a1d5-4b2b-b53f-bf7a16e12291" source="wca1_s_wca2_s25_wca1_wca2_sa22" target="pr_ac6121be-42c8-44b4-95b2-a3b9b5b2a23b_p1"> <start x="17367.0" y="1227.0"/> <end x="17399.0" y="1228.2936"/> </arc> <arc class="production" id="prod_03020e19-bfa8-452c-8edb-bdac544a7dc3" source="pr_ac6121be-42c8-44b4-95b2-a3b9b5b2a23b_p2" target="wca1_s_wca2_s27_wca1_wca2_sa24"> <start x="17429.0" y="1228.2936"/> <end x="17461.0" y="1229.5872"/> </arc> <arc class="consumption" id="cons_e2f4c2a4-fb36-4b7f-ac5b-92f578d7de69" source="wca1_s_wca2_s23_wca1_wca2_sa20" target="pr_403fe015-da00-4ad8-afb4-3167269ba8b3_p1"> <start x="17003.0" y="1135.0"/> <end x="16983.25" y="1110.0"/> </arc> <arc class="production" id="prod_0a3965e9-31d1-470c-a8e9-b377abec6eef" source="pr_403fe015-da00-4ad8-afb4-3167269ba8b3_p2" target="wca1_s_wca2_s28_wca1_wca2_sa25"> <start x="16953.25" y="1110.0"/> <end x="16933.5" y="1085.0"/> </arc> <arc class="catalysis" id="modif_e42df0d0-c415-48c7-8885-b1334b51b80f" source="wca1_s_wca2_s23_wca1_wca2_sa20" target="pr_403fe015-da00-4ad8-afb4-3167269ba8b3"> <start x="17043.0" y="1115.0"/> <next x="17042.996" y="1090.4984"/> <next x="16988.582" y="1090.5049"/> <next x="16988.584" y="1105.9391"/> <end x="16971.17" y="1105.9412"/> </arc> <arc class="consumption" id="cons_9044aed7-80ee-431e-96c1-42f99ca2fb64" source="wca1_s_wca2_s24_wca1_wca2_sa21" target="pr_7e6a7e18-c78d-4645-afa0-6895ccc17d59_p1"> <start x="17003.0" y="1323.0"/> <end x="16984.75" y="1350.5"/> </arc> <arc class="production" id="prod_a391ea64-22b6-4830-bc99-0faa0e41e66f" source="pr_7e6a7e18-c78d-4645-afa0-6895ccc17d59_p2" target="wca1_s_wca2_s29_wca1_wca2_sa26"> <start x="16954.75" y="1350.5"/> <end x="16936.5" y="1378.0"/> </arc> <arc class="catalysis" id="modif_17c7a3ab-78f1-4074-a129-80ceb03f73fb" source="wca1_s_wca2_s24_wca1_wca2_sa21" target="pr_7e6a7e18-c78d-4645-afa0-6895ccc17d59"> <start x="17043.0" y="1343.0"/> <next x="17042.998" y="1360.001"/> <next x="16992.895" y="1359.995"/> <next x="16992.895" y="1354.3553"/> <end x="16972.938" y="1354.3529"/> </arc> <arc class="consumption" id="cons_2cae65da-80b5-402a-a4a0-6cad0404caeb" source="wca1_s_wca2_s26_wca1_wca2_sa23" target="pr_e3aff89b-6b96-4cce-bc75-b2f77f3d91ec_p1"> <start x="17229.5" y="1115.0"/> <end x="17229.5" y="1111.0"/> </arc> <arc class="production" id="prod_686af4ab-c9a1-4e89-a075-e684d99ed0e5" source="pr_e3aff89b-6b96-4cce-bc75-b2f77f3d91ec_p2" target="wca1_s_wca2_s30_wca1_wca2_sa27"> <start x="17229.5" y="1081.0"/> <end x="17229.5" y="1077.0"/> </arc> <arc class="catalysis" id="modif_0e673975-f5d2-4335-8128-408ee13ff729" source="wca1_s_wca2_s23_wca1_wca2_sa20" target="pr_e3aff89b-6b96-4cce-bc75-b2f77f3d91ec"> <start x="17083.0" y="1135.0"/> <end x="17224.5" y="1096.0"/> </arc> <arc class="consumption" id="cons_b9d18503-7df3-4187-a881-bf5b1759d979" source="wca1_s_wca2_s28_wca1_wca2_sa25" target="pr_98e803ba-14b6-4879-b13e-19a59dbb8652_p1"> <start x="16973.5" y="1065.0"/> <end x="16995.0" y="1065.0"/> </arc> <arc class="production" id="prod_595edc42-468c-4b6a-acc9-053012d33b83" source="pr_98e803ba-14b6-4879-b13e-19a59dbb8652_p2" target="wca1_s_wca2_s28_wca1_wca2_sa29"> <start x="17025.0" y="1065.0"/> <end x="17046.5" y="1065.0"/> </arc> <arc class="catalysis" id="modif_8a11470f-6b27-4f46-888a-5d61428cd1db" source="wca1_s_wca2_s26_wca1_wca2_sa23" target="pr_98e803ba-14b6-4879-b13e-19a59dbb8652"> <start x="17189.5" y="1135.0"/> <end x="17010.0" y="1070.0"/> </arc> <arc class="consumption" id="cons_a7e2877a-8cbe-41e1-a2d3-68f316a38644" source="wca1_s_wca2_s29_wca1_wca2_sa26" target="pr_6211af37-0c7c-44a7-87f0-08436a3253f8_p1"> <start x="16976.5" y="1398.0"/> <end x="17014.0" y="1398.0"/> </arc> <arc class="production" id="prod_c5b8b1ff-dbcf-4c02-b7f2-e158f11dbb5e" source="pr_6211af37-0c7c-44a7-87f0-08436a3253f8_p2" target="wca1_s_wca2_s29_wca1_wca2_sa30"> <start x="17044.0" y="1398.0"/> <end x="17081.5" y="1398.0"/> </arc> <arc class="catalysis" id="modif_868e3bd8-a0d6-4507-a7cb-73a1510ce1c7" source="wca1_s_wca2_s26_wca1_wca2_sa23" target="pr_6211af37-0c7c-44a7-87f0-08436a3253f8"> <start x="17189.5" y="1135.0"/> <end x="17029.0" y="1393.0"/> </arc> <arc class="consumption" id="cons_9ce3c767-2134-4128-a023-cba35e44edcb" source="wca1_s_wca2_s30_wca1_wca2_sa27" target="pr_827cf4a9-9a11-49a3-bc83-5b050ddaf712_p1"> <start x="17269.5" y="1057.0"/> <end x="17283.5" y="1057.0"/> </arc> <arc class="production" id="prod_dac64e47-03b5-4281-81e2-def2e1f9f89c" source="pr_827cf4a9-9a11-49a3-bc83-5b050ddaf712_p2" target="wca1_s_wca2_s31_wca1_wca2_sa28"> <start x="17313.5" y="1057.0"/> <end x="17327.5" y="1057.0"/> </arc> <arc class="catalysis" id="modif_46788f17-da72-4f80-a1a2-4486f9a363dc" source="wca1_s_wca2_s26_wca1_wca2_sa23" target="pr_827cf4a9-9a11-49a3-bc83-5b050ddaf712"> <start x="17269.5" y="1135.0"/> <end x="17298.5" y="1062.0"/> </arc> <arc class="consumption" id="cons_f0ee1bf3-f942-4f73-a42d-5811a8ed2ed1" source="wca1_s_wca2_s31_wca1_wca2_sa28" target="pr_f7df33da-f809-4786-84ab-93bae9675e0d_p1"> <start x="17407.5" y="1057.0"/> <end x="17438.781" y="1121.0"/> </arc> <arc class="production" id="prod_adde7b20-e2dc-4d30-b8af-8724984f84da" source="pr_f7df33da-f809-4786-84ab-93bae9675e0d_p2" target="wca1_s_wca2_s27_wca1_wca2_sa24"> <start x="17438.781" y="1151.0"/> <end x="17470.06" y="1215.0"/> </arc> <arc class="consumption" id="cons_292bc2f9-31ca-42dd-b2f5-f195a863c013" source="wca1_s_wca2_s28_wca1_wca2_sa29" target="pr_26307717-0271-4095-9595-0821de8b9e5a_p1"> <start x="17126.5" y="1065.0"/> <end x="17278.75" y="1143.9592"/> </arc> <arc class="production" id="prod_1f52317f-f81a-49a4-984d-f688ad86545c" source="pr_26307717-0271-4095-9595-0821de8b9e5a_p2" target="wca1_s_wca2_s27_wca1_wca2_sa24"> <start x="17308.75" y="1143.9592"/> <end x="17461.0" y="1222.9185"/> </arc> <arc class="consumption" id="cons_9d364f38-6c95-489c-a0ef-df5f5f6acc2a" source="wca1_s_wca2_s29_wca1_wca2_sa30" target="pr_70f4a23c-a7e9-4ca7-a1f4-cc4e3fc72401_p1"> <start x="17161.5" y="1398.0"/> <end x="17296.25" y="1318.0063"/> </arc> <arc class="production" id="prod_a238aebf-c630-4c79-ba8d-eecea1ee3b70" source="pr_70f4a23c-a7e9-4ca7-a1f4-cc4e3fc72401_p2" target="wca1_s_wca2_s27_wca1_wca2_sa24"> <start x="17326.25" y="1318.0063"/> <end x="17461.0" y="1238.0127"/> </arc> <arc class="consumption" id="cons_0cfc4ae9-d1fb-4a6c-a240-62e8ded58623" source="wca1_s_wca2_s33_wca1_wca2_sa32" target="pr_3fc73ec2-68fe-4b9b-92fb-edff69266393_p1"> <start x="16130.0" y="690.0"/> <next x="16167.0" y="765.0"/> <end x="16219.5" y="767.5763"/> </arc> <arc class="consumption" id="cons_a62509e0-b4a0-4feb-885b-b27912b656f8" source="wca1_s_wca2_s32_wca1_wca2_sa31" target="pr_3fc73ec2-68fe-4b9b-92fb-edff69266393_p1"> <start x="16248.0" y="765.0"/> <next x="16167.0" y="765.0"/> <end x="16219.5" y="767.5763"/> </arc> <arc class="production" id="prod_c66f8863-b6fe-44e7-8f41-9d072df5a032" source="pr_3fc73ec2-68fe-4b9b-92fb-edff69266393_p2" target="wca1_s_wca2_s36_wca1_wca2_csa5"> <start x="16249.5" y="767.5763"/> <end x="16298.0" y="770.0"/> </arc> <arc class="consumption" id="addreact_68c63c83-1256-49da-b76a-7d8795da9b96" source="wca1_s_wca2_s66_wca1_wca2_sa52" target="pr_3fc73ec2-68fe-4b9b-92fb-edff69266393_p1"> <start x="16135.5" y="770.0"/> <end x="16219.5" y="767.5763"/> </arc> <arc class="consumption" id="cons_c1d329fe-e380-4f3b-a5f8-661343f7829a" source="wca1_s_wca2_s47_wca1_wca2_csa6" target="pr_35cd871b-a2b0-4300-910b-2fc06b1ef218_p1"> <start x="16658.0" y="770.0"/> <end x="16672.5" y="778.89685"/> </arc> <arc class="production" id="prod_2831dc01-d8db-4fbd-8b9a-5724e52f1086" source="pr_35cd871b-a2b0-4300-910b-2fc06b1ef218_p2" target="wca1_s_wca2_s32_wca1_wca2_sa31"> <start x="16702.5" y="778.89685"/> <next x="16717.0" y="787.79364"/> <end x="16248.0" y="789.9594"/> </arc> <arc class="production" id="prod_e74a7254-10cb-4cd7-b228-02c5139daa64" source="pr_35cd871b-a2b0-4300-910b-2fc06b1ef218_p2" target="wca1_s_wca2_s58_wca1_wca2_csa7"> <start x="16702.5" y="778.89685"/> <next x="16717.0" y="787.79364"/> <end x="16777.0" y="773.0"/> </arc> <arc class="catalysis" id="modif_380e9a08-a4b4-44ce-b644-7f4ad5d1266f" source="wca1_s_wca2_s33_wca1_wca2_sa32" target="pr_35cd871b-a2b0-4300-910b-2fc06b1ef218"> <start x="16130.0" y="690.0"/> <end x="16688.943" y="774.1098"/> </arc> <arc class="consumption" id="cons_3298abdd-8414-4af3-89f7-45d015294450" source="wca1_s_wca2_s36_wca1_wca2_csa5" target="pr_b86afff9-8918-42dc-9117-9fffaffa2ce0_p1"> <start x="16373.0" y="820.0"/> <end x="16338.0" y="876.5"/> </arc> <arc class="production" id="prod_1bc8b98c-00b6-4ad5-9f5f-1ecc5820a05f" source="pr_b86afff9-8918-42dc-9117-9fffaffa2ce0_p2" target="wca1_s_wca2_s69_wca1_wca2_csa8"> <start x="16338.0" y="906.5"/> <end x="16303.0" y="963.0"/> </arc> <arc class="catalysis" id="modif_a3b0f8f4-78d9-4c1a-944c-3485225042f3" source="wca1_s_wca2_s36_wca1_wca2_csa5" target="pr_b86afff9-8918-42dc-9117-9fffaffa2ce0"> <start x="16298.0" y="770.0"/> <next x="16277.998" y="769.99994"/> <next x="16277.997" y="884.8107"/> <end x="16335.707" y="884.81085"/> </arc> <arc class="consumption" id="cons_ca3ed19e-e32a-452a-9a5f-4b843eb0855f" source="wca1_s_wca2_s36_wca1_wca2_csa5" target="pr_27b7c911-a2f3-4f76-a3f6-0d8e646b83c5_p1"> <start x="16373.0" y="720.0"/> <next x="16685.0" y="666.0625"/> <end x="16858.5" y="696.85803"/> </arc> <arc class="consumption" id="cons_4c7d583a-a2c3-4e1f-98ed-1f298b4cf03f" source="wca1_s_wca2_s67_wca1_wca2_sa53" target="pr_27b7c911-a2f3-4f76-a3f6-0d8e646b83c5_p1"> <start x="16686.0" y="638.0"/> <next x="16685.0" y="666.0625"/> <end x="16858.5" y="696.85803"/> </arc> <arc class="production" id="prod_a28b3bc4-f762-48da-b1a1-80cb50153dbb" source="pr_27b7c911-a2f3-4f76-a3f6-0d8e646b83c5_p2" target="wca1_s_wca2_s76_wca1_wca2_csa9"> <start x="16888.5" y="696.85803"/> <end x="17058.0" y="727.0"/> </arc> <arc class="production" id="addprod_e5963b3c-7dca-45e8-89d5-db6b7f04ed0f" source="pr_27b7c911-a2f3-4f76-a3f6-0d8e646b83c5_p2" target="wca1_s_wca2_s33_wca1_wca2_sa61"> <start x="16888.5" y="696.85803"/> <end x="17060.0" y="670.0"/> </arc> <arc class="production" id="addprod_89480e51-9df9-47f7-af9e-69a9d9eb6a75" source="pr_27b7c911-a2f3-4f76-a3f6-0d8e646b83c5_p2" target="wca1_s_wca2_s32_wca1_wca2_sa58"> <start x="16888.5" y="696.85803"/> <end x="17158.0" y="765.0"/> </arc> <arc class="consumption" id="cons_9c701f76-e914-43ba-a14c-2c768acdbf4f" source="wca1_s_wca2_s32_wca1_wca2_sa58" target="pr_a7b0e7ad-5849-4885-b6aa-3dc0d16ed301_p1"> <start x="17158.0" y="775.0"/> <end x="16923.0" y="793.75"/> </arc> <arc class="production" id="prod_178a6d00-2e93-409d-a6a7-aeef220e608e" source="pr_a7b0e7ad-5849-4885-b6aa-3dc0d16ed301_p2" target="wca1_s_wca2_s47_wca1_wca2_csa6"> <start x="16893.0" y="793.75"/> <end x="16658.0" y="812.5"/> </arc> <arc class="consumption" id="cons_2750ea42-15e5-4803-9c16-b82764282beb" source="wca1_s_wca2_s82_wca1_wca2_sa64" target="pr_f930ebfe-eeac-43a2-b375-b54bcaf812dc_p1"> <start x="16049.0" y="681.0"/> <next x="16077.0" y="724.0"/> <end x="16066.444" y="729.0"/> </arc> <arc class="consumption" id="cons_b65404f0-8d86-4391-b67c-855909ab468a" source="wca1_s_wca2_s66_wca1_wca2_sa52" target="pr_f930ebfe-eeac-43a2-b375-b54bcaf812dc_p1"> <start x="16100.5" y="770.0"/> <next x="16077.0" y="724.0"/> <end x="16066.444" y="729.0"/> </arc> <arc class="production" id="prod_a14ebaf3-2094-4a3b-8917-0f686075c502" source="pr_f930ebfe-eeac-43a2-b375-b54bcaf812dc_p2" target="wca1_s_wca2_s85_wca1_wca2_csa10"> <start x="16066.444" y="759.0"/> <end x="16058.0" y="760.0"/> </arc> <arc class="consumption" id="cons_9a49c392-c27f-43e6-86b5-de6b119d752e" source="wca1_s_wca2_s85_wca1_wca2_csa10" target="pr_b33bd06a-67d3-420d-9551-e1e82eb7cdd1_p1"> <start x="16028.0" y="820.0"/> <end x="16095.5" y="876.5"/> </arc> <arc class="production" id="prod_d331cbd1-89be-44e0-b1ff-b67a25468d7f" source="pr_b33bd06a-67d3-420d-9551-e1e82eb7cdd1_p2" target="wca1_s_wca2_s88_wca1_wca2_csa11"> <start x="16095.5" y="906.5"/> <end x="16163.0" y="963.0"/> </arc> <arc class="consumption" id="cons_a565fbdf-1804-4200-ad56-b9fa1b2e8099" source="wca1_s_wca2_s318_wca1_wca2_csa12" target="pr_6b225572-fa26-4837-8865-0d6ac83856a1_p1"> <start x="17423.0" y="833.0"/> <end x="17027.0" y="897.84454"/> </arc> <arc class="production" id="prod_51787269-942d-4141-8b1f-b0eafec1cee6" source="pr_6b225572-fa26-4837-8865-0d6ac83856a1_p2" target="wca1_s_wca2_s80_wca1_wca2_sa62"> <start x="16997.0" y="897.84454"/> <end x="16601.0" y="962.6891"/> </arc> <arc class="consumption" id="cons_67e72377-9049-4e57-9b35-440cd90530f0" source="wca1_s_wca2_s96_wca1_wca2_sa72" target="pr_8c5ae994-f3a2-4569-80cd-8cdc1ed8e3d8_p1"> <start x="17260.0" y="690.0"/> <next x="17289.5" y="783.0"/> <end x="17343.25" y="783.0"/> </arc> <arc class="consumption" id="cons_f30dcd0d-fac9-4be2-85c8-5c38dcf025e8" source="wca1_s_wca2_s95_wca1_wca2_sa69" target="pr_8c5ae994-f3a2-4569-80cd-8cdc1ed8e3d8_p1"> <start x="17378.0" y="783.0"/> <next x="17289.5" y="783.0"/> <end x="17343.25" y="783.0"/> </arc> <arc class="production" id="prod_1eba36bc-cd55-4814-a88c-bd6f136c8d17" source="pr_8c5ae994-f3a2-4569-80cd-8cdc1ed8e3d8_p2" target="wca1_s_wca2_s318_wca1_wca2_csa12"> <start x="17373.25" y="783.0"/> <end x="17423.0" y="783.0"/> </arc> <arc class="consumption" id="cons_2927f286-183d-4005-8515-430319aaf6a8" source="wca1_s_wca2_s98_wca1_wca2_sa74" target="pr_3b3f88fe-e4f0-46da-a52e-cac40d147cbb_p1"> <start x="17598.0" y="805.0"/> <next x="17688.0" y="821.0"/> <end x="17688.0" y="817.5"/> </arc> <arc class="consumption" id="cons_4cb6fc78-3ab1-48d9-ab13-9f7912322ec9" source="wca1_s_wca2_s98_wca1_wca2_sa77" target="pr_3b3f88fe-e4f0-46da-a52e-cac40d147cbb_p1"> <start x="17688.0" y="805.0"/> <next x="17688.0" y="821.0"/> <end x="17688.0" y="817.5"/> </arc> <arc class="production" id="prod_b93e4d70-e5e6-4d73-bead-4f6a15a03277" source="pr_3b3f88fe-e4f0-46da-a52e-cac40d147cbb_p2" target="wca1_s_wca2_s320_wca1_wca2_csa13"> <start x="17688.0" y="847.5"/> <end x="17688.0" y="840.0"/> </arc> <arc class="consumption" id="cons_d2dcd90e-6b5c-4547-8040-a169581a8b87" source="wca1_s_wca2_s320_wca1_wca2_csa13" target="pr_8cf2d23f-fdeb-4bc9-b263-2868f1edaf1f_p1"> <start x="17643.0" y="890.0"/> <end x="17137.0" y="928.03973"/> </arc> <arc class="production" id="prod_4f3261d3-fdcf-4be9-a1a0-786ef7d0b9a0" source="pr_8cf2d23f-fdeb-4bc9-b263-2868f1edaf1f_p2" target="wca1_s_wca2_s80_wca1_wca2_sa62"> <start x="17107.0" y="928.03973"/> <end x="16601.0" y="966.07947"/> </arc> <arc class="inhibition" id="direct_9e88797d-d5a9-4182-9f08-2d2080d6712d" source="wca1_s_wca2_s102_wca1_wca2_sa78" target="wca1_s_wca2_s80_wca1_wca2_sa62"> <start x="17658.0" y="985.0"/> <end x="16593.5" y="976.5"/> </arc> <arc class="consumption" id="cons_947c01ac-52de-4608-994b-803eb78c3ca0" source="wca1_s_wca2_s314_wca1_wca2_csa14" target="pr_ba96da80-510e-4cb8-8156-16e8504ea82a_p1"> <start x="15543.5" y="1262.0"/> <next x="15521.0" y="1299.5"/> <end x="15546.378" y="1329.5"/> </arc> <arc class="consumption" id="cons_35cc7c31-dfe9-45fc-95d6-b61ca737435e" source="wca1_s_wca2_s114_wca1_wca2_csa15" target="pr_ba96da80-510e-4cb8-8156-16e8504ea82a_p1"> <start x="15522.0" y="1671.0"/> <next x="15521.0" y="1299.5"/> <end x="15546.378" y="1329.5"/> </arc> <arc class="production" id="prod_c3c25f54-9cc7-460c-9f10-432e94bef118" source="pr_ba96da80-510e-4cb8-8156-16e8504ea82a_p2" target="wca1_s_wca2_s125_wca1_wca2_csa16"> <start x="15546.378" y="1359.5"/> <end x="15569.5" y="1385.5"/> </arc> <arc class="catalysis" id="modif_cc46d3cb-ec98-4311-af36-ed5b13c4b767" source="wca1_s_wca2_s109_wca1_wca2_sa84" target="pr_ba96da80-510e-4cb8-8156-16e8504ea82a"> <start x="15590.0" y="1338.0"/> <end x="15550.733" y="1342.044"/> </arc> <arc class="production" id="addprod_4885fd7a-0188-43e1-98d6-9c797e25d524" source="pr_ba96da80-510e-4cb8-8156-16e8504ea82a_p2" target="wca1_s_wca2_s106_wca1_wca2_sa81"> <start x="15546.378" y="1359.5"/> <end x="15462.0" y="1330.5"/> </arc> <arc class="consumption" id="cons_a77bd9cc-f942-4379-bb58-733b365aad54" source="wca1_s_wca2_s125_wca1_wca2_csa16" target="pr_676b23f0-2437-4cc8-b88d-cd12b6d1eaa1_p1"> <start x="15620.0" y="1510.0"/> <end x="15786.5" y="1500.75"/> </arc> <arc class="production" id="prod_76cc629e-4eb7-45b9-9969-6053d8a67e56" source="pr_676b23f0-2437-4cc8-b88d-cd12b6d1eaa1_p2" target="wca1_s_wca2_s126_wca1_wca2_csa17"> <start x="15816.5" y="1500.75"/> <end x="15983.0" y="1491.5"/> </arc> <arc class="consumption" id="cons_c2e451c0-1482-4ec0-986a-1a81331c1707" source="wca1_s_wca2_s133_wca1_wca2_sa102" target="pr_61ba244c-96cf-4fc2-aaf5-494edf0f84ae_p1"> <start x="16035.0" y="1738.0"/> <end x="16069.0" y="1738.0"/> </arc> <arc class="production" id="prod_9d17ac12-d02a-4077-afc7-01cedb0fb072" source="pr_61ba244c-96cf-4fc2-aaf5-494edf0f84ae_p2" target="wca1_s_wca2_s133_wca1_wca2_sa103"> <start x="16099.0" y="1738.0"/> <end x="16133.0" y="1738.0"/> </arc> <arc class="catalysis" id="modif_620c401d-6123-4902-aa8c-c25e945ce744" source="wca1_s_wca2_s126_wca1_wca2_csa17" target="pr_61ba244c-96cf-4fc2-aaf5-494edf0f84ae"> <start x="16084.0" y="1616.0"/> <end x="16084.0" y="1733.0"/> </arc> <arc class="consumption" id="cons_bfb3e812-fa0c-4cfe-9151-c19c69d37ce0" source="wca1_s_wca2_s3_wca1_wca2_sa3" target="pr_174f3144-cd33-4872-8fb1-3bb14dbaa163_p1"> <start x="15774.0" y="959.86597"/> <end x="15774.0" y="1336.933"/> </arc> <arc class="production" id="prod_b1822c6c-42ce-4714-a59c-2268954097a2" source="pr_174f3144-cd33-4872-8fb1-3bb14dbaa163_p2" target="wca1_s_wca2_s135_wca1_wca2_sa104"> <start x="15774.0" y="1366.933"/> <end x="15774.0" y="1744.0"/> </arc> <arc class="catalysis" id="modif_30a189ff-0a64-403d-b0f2-bd9c3eb194ff" source="wca1_s_wca2_s133_wca1_wca2_sa103" target="pr_174f3144-cd33-4872-8fb1-3bb14dbaa163"> <start x="16173.0" y="1718.0"/> <end x="15779.0" y="1351.933"/> </arc> <arc class="stimulation" id="direct_171db334-2421-424f-bbad-da261664392e" source="wca1_s_wca2_s136_wca1_wca2_sa105" target="wca1_s_wca2_s114_wca1_wca2_csa15"> <start x="15633.0" y="1836.0"/> <end x="15522.0" y="1791.0"/> </arc> <arc class="consumption" id="cons_9950ee7e-c0f6-4b30-a07d-576e32c201e3" source="wca1_s_wca2_s135_wca1_wca2_sa104" target="pr_c405c812-3eb4-4ce0-93ff-a11627180eae_p1"> <start x="15774.0" y="1784.0"/> <end x="15870.5" y="1821.75"/> </arc> <arc class="production" id="prod_41662514-b24e-4726-a628-671e69bccbb7" source="pr_c405c812-3eb4-4ce0-93ff-a11627180eae_p2" target="wca1_s_wca2_s137_wca1_wca2_sa106"> <start x="15900.5" y="1821.75"/> <end x="15997.0" y="1859.5"/> </arc> <arc class="stimulation" id="direct_b99a8f75-599b-495e-8495-6f36e5cb40a0" source="wca1_s_wca2_s169_wca1_wca2_csa20" target="wca1_s_wca2_s138_wca1_wca2_sa107"> <start x="16218.0" y="1860.0"/> <end x="16277.0" y="1860.0"/> </arc> <arc class="stimulation" id="direct_8ade1ac6-79fa-44be-bd64-c4997998f108" source="wca1_s_wca2_s169_wca1_wca2_csa20" target="wca1_s_wca2_s139_wca1_wca2_sa108"> <start x="16218.0" y="1920.0"/> <end x="16280.0" y="1921.0"/> </arc> <arc class="consumption" id="cons_253a1a0f-f730-4608-bfc7-1ec1a68766f8" source="wca1_s_wca2_s126_wca1_wca2_csa17" target="pr_0d4d8857-3504-4456-826c-71d4d9c48cdb_p1"> <start x="16185.0" y="1491.5"/> <end x="16209.5" y="1491.5"/> </arc> <arc class="production" id="prod_4eaccc77-bc2c-43dc-b971-1c20d13b3dcd" source="pr_0d4d8857-3504-4456-826c-71d4d9c48cdb_p2" target="wca1_s_wca2_s147_wca1_wca2_csa18"> <start x="16239.5" y="1491.5"/> <end x="16264.0" y="1491.5"/> </arc> <arc class="catalysis" id="modif_3f12073c-4a50-4627-85c1-b9f30c7b42be" source="wca1_s_wca2_s133_wca1_wca2_sa103" target="pr_0d4d8857-3504-4456-826c-71d4d9c48cdb"> <start x="16173.0" y="1718.0"/> <end x="16224.5" y="1496.5"/> </arc> <arc class="consumption" id="cons_b0e29c92-f6c0-4f85-aa2f-8077cd4e58f9" source="wca1_s_wca2_s147_wca1_wca2_csa18" target="pr_5cd10411-0076-4bf6-967b-5da2bd4f97fa_p1"> <start x="16466.0" y="1491.5"/> <end x="16476.0" y="1490.5741"/> </arc> <arc class="production" id="prod_c5baa37b-9fcd-448e-9fb6-009d601f65e1" source="pr_5cd10411-0076-4bf6-967b-5da2bd4f97fa_p2" target="wca1_s_wca2_s161_wca1_wca2_csa19"> <start x="16506.0" y="1490.5741"/> <next x="16516.0" y="1489.6482"/> <end x="16561.0" y="1492.6667"/> </arc> <arc class="production" id="prod_0d5006c4-610e-4331-9fa6-3d3611252361" source="pr_5cd10411-0076-4bf6-967b-5da2bd4f97fa_p2" target="wca1_s_wca2_s135_wca1_wca2_sa104"> <start x="16506.0" y="1490.5741"/> <next x="16516.0" y="1489.6482"/> <end x="15814.0" y="1749.2815"/> </arc> <arc class="consumption" id="cons_3e6bc0ad-1e86-448c-bee9-7336c6c5d6c0" source="wca1_s_wca2_s137_wca1_wca2_sa106" target="pr_9b2a6463-d5eb-4e91-a52a-a093b52d2be0_p1"> <start x="16077.0" y="1859.5"/> <next x="16101.0" y="1890.0"/> <end x="16096.5" y="1890.0"/> </arc> <arc class="consumption" id="cons_2c9bd3ce-1318-43fc-a6c2-4ef9664be1aa" source="wca1_s_wca2_s167_wca1_wca2_sa121" target="pr_9b2a6463-d5eb-4e91-a52a-a093b52d2be0_p1"> <start x="16079.0" y="1930.0"/> <next x="16101.0" y="1890.0"/> <end x="16096.5" y="1890.0"/> </arc> <arc class="production" id="prod_f6beb82b-7841-42e1-b901-dca3c142f0a0" source="pr_9b2a6463-d5eb-4e91-a52a-a093b52d2be0_p2" target="wca1_s_wca2_s169_wca1_wca2_csa20"> <start x="16126.5" y="1890.0"/> <end x="16118.0" y="1890.0"/> </arc> <arc class="consumption" id="cons_67c45d84-8c57-4ac6-82e9-2fb700db86b9" source="wca1_s_wca2_s114_wca1_wca2_csa15" target="pr_a2e06142-216a-4fa0-9525-f8ad0149b9bd_p1"> <start x="15572.0" y="1731.0"/> <end x="15770.5" y="1830.5"/> </arc> <arc class="production" id="prod_3871f1ae-f9cc-4f53-b57d-8dfdbf1c7c13" source="pr_a2e06142-216a-4fa0-9525-f8ad0149b9bd_p2" target="wca1_s_wca2_s167_wca1_wca2_sa121"> <start x="15800.5" y="1830.5"/> <end x="15999.0" y="1930.0"/> </arc> <arc class="stimulation" id="direct_afc1fea6-d37d-4a75-8501-04611cf9dd7a" source="wca1_s_wca2_s47_wca1_wca2_csa6" target="wca1_s_wca2_s80_wca1_wca2_sa62"> <start x="16558.0" y="855.0"/> <end x="16561.0" y="954.0"/> </arc> <arc class="consumption" id="cons_6a164855-35dd-42e2-9aa9-7c0c85e51e67" source="wca1_s_wca2_s106_wca1_wca2_sa131" target="pr_71ad9266-e1b4-41b8-b199-650b202590d3_p1"> <start x="15473.0" y="1012.0"/> <next x="15541.5" y="1044.0"/> <end x="15542.584" y="1055.0"/> </arc> <arc class="consumption" id="cons_adcbaa86-a638-4392-8c3b-f5c8c3b6e123" source="wca1_s_wca2_s202_wca1_wca2_sa129" target="pr_71ad9266-e1b4-41b8-b199-650b202590d3_p1"> <start x="15746.5" y="1184.0"/> <next x="15541.5" y="1044.0"/> <end x="15542.584" y="1055.0"/> </arc> <arc class="production" id="prod_b21223b6-96b3-411a-9c28-ea659ef5e16f" source="pr_71ad9266-e1b4-41b8-b199-650b202590d3_p2" target="wca1_s_wca2_s314_wca1_wca2_csa14"> <start x="15542.584" y="1085.0"/> <end x="15543.5" y="1092.0"/> </arc> <arc class="consumption" id="addreact_fd9ff3bc-92ce-41fb-83c8-852d6d048d10" source="wca1_s_wca2_s178_wca1_wca2_sa130" target="pr_71ad9266-e1b4-41b8-b199-650b202590d3_p1"> <start x="15703.0" y="1012.0"/> <end x="15542.584" y="1055.0"/> </arc> <arc class="consumption" id="addreact_90fb7844-d382-48fd-99a9-dea9cad80691" source="wca1_s_wca2_s176_wca1_wca2_sa128" target="pr_71ad9266-e1b4-41b8-b199-650b202590d3_p1"> <start x="15540.0" y="964.0"/> <end x="15542.584" y="1055.0"/> </arc> <arc class="consumption" id="addreact_2947ccce-640b-4a91-a828-abacde99cef7" source="wca1_s_wca2_s172_wca1_wca2_sa124" target="pr_71ad9266-e1b4-41b8-b199-650b202590d3_p1"> <start x="15687.0" y="1082.0"/> <end x="15542.584" y="1055.0"/> </arc> <arc class="consumption" id="addreact_df088ad2-9df0-4c7d-9f3e-62f4c8431332" source="wca1_s_wca2_s174_wca1_wca2_sa126" target="pr_71ad9266-e1b4-41b8-b199-650b202590d3_p1"> <start x="15701.0" y="1138.0"/> <end x="15542.584" y="1055.0"/> </arc> <arc class="consumption" id="addreact_cc1e513d-1c7e-4a9e-b066-be4d58065fb1" source="wca1_s_wca2_s182_wca1_wca2_sa132" target="pr_71ad9266-e1b4-41b8-b199-650b202590d3_p1"> <start x="15644.0" y="959.86597"/> <end x="15542.584" y="1055.0"/> </arc> <arc class="consumption" id="cons_5d9d49e9-733f-40ba-b8f3-4f4fc3c7159b" source="wca1_s_wca2_s3_wca1_wca2_sa3" target="pr_77635fd7-d7f8-4501-b03c-d42c6494ec5b_p1"> <start x="15734.0" y="939.86597"/> <end x="15724.0" y="939.86597"/> </arc> <arc class="production" id="prod_6e308b2c-c43b-4398-a8e2-8c520b7422be" source="pr_77635fd7-d7f8-4501-b03c-d42c6494ec5b_p2" target="wca1_s_wca2_s182_wca1_wca2_sa132"> <start x="15694.0" y="939.86597"/> <end x="15684.0" y="939.86597"/> </arc> <arc class="catalysis" id="modif_01cfd47c-6d0a-44f6-b6b9-2d44b063587a" source="wca1_s_wca2_s183_wca1_wca2_sa133" target="pr_77635fd7-d7f8-4501-b03c-d42c6494ec5b"> <start x="15821.0" y="1024.0"/> <end x="15714.0" y="944.86597"/> </arc> <arc class="consumption" id="cons_5150e4cb-f442-410d-aae1-5f9836577fe4" source="wca1_s_wca2_s183_wca1_wca2_sa134" target="pr_fcafc466-6ab2-4d88-b262-bf8884fff44e_p1"> <start x="15861.0" y="1116.0"/> <end x="15861.0" y="1095.0"/> </arc> <arc class="production" id="prod_c914315d-e0a2-410a-8ad7-71b635b5c89d" source="pr_fcafc466-6ab2-4d88-b262-bf8884fff44e_p2" target="wca1_s_wca2_s183_wca1_wca2_sa133"> <start x="15861.0" y="1065.0"/> <end x="15861.0" y="1044.0"/> </arc> <arc class="catalysis" id="modif_d9026963-c307-4440-b918-e31cd7d7ccec" source="wca1_s_wca2_s189_wca1_wca2_sa135" target="pr_fcafc466-6ab2-4d88-b262-bf8884fff44e"> <start x="15922.0" y="1081.0"/> <end x="15866.0" y="1080.0"/> </arc> <arc class="consumption" id="cons_01cbca56-ec3c-439e-a189-e1bfb22821e0" source="wca1_s_wca2_s177_wca1_wca2_sa136" target="pr_e84028fd-c198-4f9f-af88-c98b2cec2c50_p1"> <start x="15746.5" y="1356.0"/> <end x="15747.0" y="1350.0"/> </arc> <arc class="production" id="prod_f514267f-6aaa-4878-b647-007ef44b440a" source="pr_e84028fd-c198-4f9f-af88-c98b2cec2c50_p2" target="wca1_s_wca2_s192_wca1_wca2_sa137"> <start x="15747.0" y="1320.0"/> <end x="15747.5" y="1314.0"/> </arc> <arc class="catalysis" id="modif_4a57e162-c85b-4eaf-893e-7ad7368e0333" source="wca1_s_wca2_s323_wca1_wca2_csa21" target="pr_e84028fd-c198-4f9f-af88-c98b2cec2c50"> <start x="15836.0" y="1335.0"/> <end x="15751.999" y="1335.119"/> </arc> <arc class="consumption" id="cons_f58a5ca0-819e-4f9e-95e3-31eeb780aa5f" source="wca1_s_wca2_s192_wca1_wca2_sa137" target="pr_a64fb212-a590-493a-8930-aed880119a00_p1"> <start x="15747.5" y="1273.0"/> <end x="15747.0" y="1264.0"/> </arc> <arc class="production" id="prod_36faf6a2-750f-490b-ba77-c78f12119e7f" source="pr_a64fb212-a590-493a-8930-aed880119a00_p2" target="wca1_s_wca2_s202_wca1_wca2_sa129"> <start x="15747.0" y="1234.0"/> <end x="15746.5" y="1225.0"/> </arc> <arc class="catalysis" id="modif_323fbaa2-7fd3-4bea-9792-be86d91eb126" source="wca1_s_wca2_s211_wca1_wca2_sa142" target="pr_a64fb212-a590-493a-8930-aed880119a00"> <start x="15838.0" y="1249.0"/> <end x="15751.999" y="1248.8959"/> </arc> <arc class="consumption" id="cons_3c87ccc0-9b77-43f5-87e6-c25425976791" source="wca1_s_wca2_s212_wca1_wca2_sa143" target="pr_1bb020cf-309d-41bf-8090-3ef6592cdb31_p1"> <start x="15532.0" y="1909.0"/> <next x="15532.0" y="2002.0"/> <end x="15532.0" y="2005.5"/> </arc> <arc class="consumption" id="cons_368b0bd9-9455-4849-9550-7aae7a309c2b" source="wca1_s_wca2_s213_wca1_wca2_sa144" target="pr_1bb020cf-309d-41bf-8090-3ef6592cdb31_p1"> <start x="15533.0" y="1985.0"/> <next x="15532.0" y="2002.0"/> <end x="15532.0" y="2005.5"/> </arc> <arc class="production" id="prod_7dbd710e-1ab4-4ea2-8c4f-75d611a86779" source="pr_1bb020cf-309d-41bf-8090-3ef6592cdb31_p2" target="wca1_s_wca2_s214_wca1_wca2_csa22"> <start x="15532.0" y="2035.5"/> <end x="15532.0" y="2035.0"/> </arc> <arc class="consumption" id="addreact_6e3e444a-fad6-4d2e-8826-c729fe1a5da3" source="wca1_s_wca2_s221_wca1_wca2_sa149" target="pr_1bb020cf-309d-41bf-8090-3ef6592cdb31_p1"> <start x="15601.0" y="1993.0"/> <end x="15532.0" y="2005.5"/> </arc> <arc class="consumption" id="cons_9658552e-0f44-4db8-af91-1dae91d15a5d" source="wca1_s_wca2_s214_wca1_wca2_csa22" target="pr_c23f2882-4c36-4920-a10e-70f731615c49_p1"> <start x="15532.0" y="2313.0"/> <end x="15532.0" y="2326.5"/> </arc> <arc class="production" id="prod_9ceacd33-e24d-482b-8040-cb9bd8583408" source="pr_c23f2882-4c36-4920-a10e-70f731615c49_p2" target="wca1_s_wca2_s315_wca1_wca2_csa23"> <start x="15532.0" y="2356.5"/> <end x="15532.0" y="2370.0"/> </arc> <arc class="consumption" id="cons_8bab7a2a-ef86-4c52-ba84-37bc0761e072" source="wca1_s_wca2_s315_wca1_wca2_csa23" target="pr_5ef9c70c-ca5f-43a5-8097-0748607030e6_p1"> <start x="15585.0" y="2509.0"/> <end x="16068.247" y="1761.5"/> </arc> <arc class="production" id="prod_5efbd975-8967-4f24-9599-0db2dbde9fad" source="pr_5ef9c70c-ca5f-43a5-8097-0748607030e6_p2" target="wca1_s_wca2_s80_wca1_wca2_sa62"> <start x="16068.247" y="1731.5"/> <end x="16551.494" y="984.0"/> </arc> <arc class="consumption" id="cons_feff7dc2-e68f-4568-a3a7-2e65a6ec9781" source="wca1_s_wca2_s2_wca1_wca2_sa2" target="pr_4c8d4fbe-990a-4873-8d34-cebea16e7cbb_p1"> <start x="15956.25" y="933.0"/> <next x="17290.0" y="1503.0"/> <end x="17292.5" y="1503.0"/> </arc> <arc class="consumption" id="cons_22b2f49b-07e5-4c1d-95bc-1f013f4aef31" source="wca1_s_wca2_s234_wca1_wca2_sa159" target="pr_4c8d4fbe-990a-4873-8d34-cebea16e7cbb_p1"> <start x="17290.0" y="1430.5"/> <next x="17290.0" y="1503.0"/> <end x="17292.5" y="1503.0"/> </arc> <arc class="production" id="prod_69ef1aac-0025-49b1-996c-21909426da00" source="pr_4c8d4fbe-990a-4873-8d34-cebea16e7cbb_p2" target="wca1_s_wca2_s235_wca1_wca2_csa24"> <start x="17322.5" y="1503.0"/> <end x="17321.0" y="1503.0"/> </arc> <arc class="consumption" id="cons_b7eb60a9-495c-4314-934f-c9b1c895e30b" source="wca1_s_wca2_s235_wca1_wca2_csa24" target="pr_44d3ae61-d93a-40bc-a2af-91f3ebc8792d_p1"> <start x="17421.0" y="1503.0"/> <end x="17440.0" y="1503.5"/> </arc> <arc class="production" id="prod_1bee4518-d8ce-41d3-90ec-e65b28d5718d" source="pr_44d3ae61-d93a-40bc-a2af-91f3ebc8792d_p2" target="wca1_s_wca2_s238_wca1_wca2_csa25"> <start x="17470.0" y="1503.5"/> <end x="17489.0" y="1504.0"/> </arc> <arc class="stimulation" id="modif_927f3d37-bc1f-47b7-87ac-173b402a605a" source="wca1_s_wca2_s245_wca1_wca2_sa166" target="pr_44d3ae61-d93a-40bc-a2af-91f3ebc8792d"> <start x="17767.0" y="1439.5585"/> <end x="17455.074" y="1498.5005"/> </arc> <arc class="consumption" id="cons_154fd8e5-ac33-447c-bbc7-6420e7abbe80" source="wca1_s_wca2_s238_wca1_wca2_csa25" target="pr_a8ade626-40f3-43b3-b9b3-1985ef86a42c_p1"> <start x="17589.0" y="1474.0"/> <next x="17662.5" y="1474.0"/> <end x="17662.5" y="1447.0"/> </arc> <arc class="consumption" id="cons_db0d32e4-14bf-4d7b-a361-07d00771f218" source="wca1_s_wca2_s213_wca1_wca2_sa162" target="pr_a8ade626-40f3-43b3-b9b3-1985ef86a42c_p1"> <start x="17687.0" y="1496.0"/> <next x="17662.5" y="1474.0"/> <end x="17662.5" y="1447.0"/> </arc> <arc class="production" id="prod_c5403c10-04da-4d37-a765-2740e24ab6e3" source="pr_a8ade626-40f3-43b3-b9b3-1985ef86a42c_p2" target="wca1_s_wca2_s241_wca1_wca2_csa26"> <start x="17662.5" y="1417.0"/> <end x="17662.5" y="1394.0"/> </arc> <arc class="stimulation" id="modif_e6f5e712-a02b-416b-b4d8-ab5b409bce12" source="wca1_s_wca2_s245_wca1_wca2_sa166" target="pr_a8ade626-40f3-43b3-b9b3-1985ef86a42c"> <start x="17767.0" y="1432.0"/> <end x="17667.5" y="1432.0"/> </arc> <arc class="consumption" id="cons_4519dc81-3457-473d-9eb5-9c9537702c73" source="wca1_s_wca2_s241_wca1_wca2_csa26" target="pr_d739d4fb-8b7e-47f6-a436-70f5a8d3b323_p1"> <start x="17613.0" y="1221.0"/> <end x="17122.0" y="1099.7909"/> </arc> <arc class="production" id="prod_73b352de-a76d-408d-bec5-c1cf519db4ec" source="pr_d739d4fb-8b7e-47f6-a436-70f5a8d3b323_p2" target="wca1_s_wca2_s80_wca1_wca2_sa62"> <start x="17092.0" y="1099.7909"/> <end x="16601.0" y="978.5817"/> </arc> <arc class="consumption" id="cons_6fcce25d-8377-4003-b528-d76756eb975f" source="wca1_s_wca2_s3_wca1_wca2_sa3" target="pr_286cb0f3-3fc6-4678-b3c2-0a48560a75ec_p1"> <start x="15814.0" y="939.86597"/> <end x="15924.5" y="1048.933"/> </arc> <arc class="production" id="prod_b3a33e07-105d-4613-95de-0e1cfb7d4bea" source="pr_286cb0f3-3fc6-4678-b3c2-0a48560a75ec_p2" target="wca1_s_wca2_s247_wca1_wca2_sa168"> <start x="15954.5" y="1048.933"/> <end x="16065.0" y="1158.0"/> </arc> <arc class="catalysis" id="modif_3fe8e287-8751-4ecb-87fd-732942e772c1" source="wca1_s_wca2_s248_wca1_wca2_sa169" target="pr_286cb0f3-3fc6-4678-b3c2-0a48560a75ec"> <start x="15953.0" y="1170.0"/> <end x="15936.22" y="1052.7069"/> </arc> <arc class="stimulation" id="direct_92e4c963-2726-4d96-93e7-70ffed99b3c8" source="wca1_s_wca2_s247_wca1_wca2_sa168" target="wca1_s_wca2_s80_wca1_wca2_sa62"> <start x="16145.0" y="1158.0"/> <end x="16527.984" y="984.0"/> </arc> <arc class="consumption" id="cons_c5e3804d-22ec-4bba-88bc-d9b5e19863fd" source="wca1_s_wca2_s249_wca1_wca2_sa170" target="pr_bdd7dd16-e73d-4cf4-99c3-8f750a2a7b86_p1"> <start x="16184.0" y="1275.0"/> <end x="16219.5" y="1275.5"/> </arc> <arc class="production" id="prod_b4dc58ed-9d7e-45b7-9a59-8fd51bc2ba9a" source="pr_bdd7dd16-e73d-4cf4-99c3-8f750a2a7b86_p2" target="wca1_s_wca2_s250_wca1_wca2_sa171"> <start x="16249.5" y="1275.5"/> <end x="16285.0" y="1276.0"/> </arc> <arc class="catalysis" id="modif_9f5e3a59-2fa3-414d-864a-85df5bae2524" source="wca1_s_wca2_s251_wca1_wca2_sa172" target="pr_bdd7dd16-e73d-4cf4-99c3-8f750a2a7b86"> <start x="16235.0" y="1216.0"/> <end x="16234.55" y="1270.5002"/> </arc> <arc class="consumption" id="cons_ddacddad-109c-4f15-bc2d-c7639e1c35ac" source="wca1_s_wca2_s250_wca1_wca2_sa171" target="pr_c8486698-5109-4fed-ad6b-a69e40e8aff2_p1"> <start x="16365.0" y="1276.0"/> <next x="16412.0" y="1256.0"/> <end x="16434.84" y="1216.625"/> </arc> <arc class="consumption" id="cons_3b2c40c6-6766-4b94-8d73-381d42e197e9" source="wca1_s_wca2_s253_wca1_wca2_csa27" target="pr_c8486698-5109-4fed-ad6b-a69e40e8aff2_p1"> <start x="16456.0" y="1256.5"/> <next x="16412.0" y="1256.0"/> <end x="16434.84" y="1216.625"/> </arc> <arc class="production" id="prod_a660d53a-4a7b-4a19-9d16-e36678cfc9bd" source="pr_c8486698-5109-4fed-ad6b-a69e40e8aff2_p2" target="wca1_s_wca2_s322_wca1_wca2_csa28"> <start x="16434.84" y="1186.625"/> <end x="16456.0" y="1151.25"/> </arc> <arc class="inhibition" id="direct_817123e9-707a-464a-8198-56a17b146a92" source="wca1_s_wca2_s322_wca1_wca2_csa28" target="wca1_s_wca2_s80_wca1_wca2_sa62"> <start x="16561.5" y="1060.5"/> <end x="16561.082" y="984.0"/> </arc> <arc class="consumption" id="cons_238a2796-7af9-491e-bdc0-6126412afb4a" source="wca1_s_wca2_s262_wca1_wca2_sa180" target="pr_1a8bd154-d98e-42a8-9051-5082a4f163b4_p1"> <start x="15571.0" y="2700.0"/> <next x="15677.0" y="2700.0"/> <end x="15720.958" y="2623.25"/> </arc> <arc class="consumption" id="cons_056efbc1-2ede-421d-8d44-2b7fcbb87f91" source="wca1_s_wca2_s182_wca1_wca2_sa183" target="pr_1a8bd154-d98e-42a8-9051-5082a4f163b4_p1"> <start x="15677.0" y="2734.0"/> <next x="15677.0" y="2700.0"/> <end x="15720.958" y="2623.25"/> </arc> <arc class="production" id="prod_b48d463f-916b-41af-81c8-71751e8a8c42" source="pr_1a8bd154-d98e-42a8-9051-5082a4f163b4_p2" target="wca1_s_wca2_s265_wca1_wca2_csa29"> <start x="15720.958" y="2593.25"/> <end x="15763.0" y="2520.5"/> </arc> <arc class="consumption" id="addreact_fbd22af5-0259-4961-b849-7bec7772597b" source="wca1_s_wca2_s268_wca1_wca2_sa182" target="pr_1a8bd154-d98e-42a8-9051-5082a4f163b4_p1"> <start x="15529.25" y="2788.0"/> <end x="15720.958" y="2623.25"/> </arc> <arc class="consumption" id="cons_c72f361b-040d-465c-bbbd-cd21fe6b9b1a" source="wca1_s_wca2_s265_wca1_wca2_csa29" target="pr_d46b4dc1-2700-4b77-9b9c-410d2969ddfb_p1"> <start x="15877.5" y="2453.0"/> <end x="15878.0" y="2385.75"/> </arc> <arc class="production" id="prod_84f66816-0623-40eb-a57d-f12d58c50e2e" source="pr_d46b4dc1-2700-4b77-9b9c-410d2969ddfb_p2" target="wca1_s_wca2_s269_wca1_wca2_csa30"> <start x="15878.0" y="2355.75"/> <end x="15878.5" y="2288.5"/> </arc> <arc class="catalysis" id="modif_550c468c-4156-4e84-8073-36d8f9611f87" source="wca1_s_wca2_s133_wca1_wca2_sa103" target="pr_d46b4dc1-2700-4b77-9b9c-410d2969ddfb"> <start x="16173.0" y="1758.0"/> <end x="15883.0" y="2370.7803"/> </arc> <arc class="consumption" id="cons_4927b570-aec6-406f-b543-cde344e60e61" source="wca1_s_wca2_s269_wca1_wca2_csa30" target="pr_1d187c47-7905-4f7c-b144-cc40fa25d62c_p1"> <start x="15878.5" y="2153.5"/> <end x="15878.5" y="2121.5"/> </arc> <arc class="production" id="prod_514dd78a-b23f-41d5-b816-bf2f06ead951" source="pr_1d187c47-7905-4f7c-b144-cc40fa25d62c_p2" target="wca1_s_wca2_s280_wca1_wca2_csa31"> <start x="15878.5" y="2091.5"/> <next x="15878.5" y="2059.5"/> <end x="15942.0" y="2056.0"/> </arc> <arc class="production" id="prod_ccb5b7c6-01f7-468f-bc2b-d3ec8ca704d8" source="pr_1d187c47-7905-4f7c-b144-cc40fa25d62c_p2" target="wca1_s_wca2_s135_wca1_wca2_sa104"> <start x="15878.5" y="2091.5"/> <next x="15878.5" y="2059.5"/> <end x="15774.0" y="1784.0"/> </arc> <arc class="consumption" id="cons_a0a345ba-f5f9-4392-9238-af5fb6e0547f" source="wca1_s_wca2_s32_wca1_wca2_sa58" target="pr_a107e8c6-7ab0-4496-86d4-2d9aec989c28_p1"> <start x="17198.0" y="795.0"/> <next x="17515.0" y="1617.0"/> <end x="17554.0" y="1617.0"/> </arc> <arc class="consumption" id="cons_ba591d3d-f1a5-4176-be7f-b9f8b13feb78" source="wca1_s_wca2_s281_wca1_wca2_sa192" target="pr_a107e8c6-7ab0-4496-86d4-2d9aec989c28_p1"> <start x="17660.0" y="1123.0"/> <next x="17515.0" y="1617.0"/> <end x="17554.0" y="1617.0"/> </arc> <arc class="production" id="prod_d2da0d72-fbc0-407f-8d4d-4b229520208a" source="pr_a107e8c6-7ab0-4496-86d4-2d9aec989c28_p2" target="wca1_s_wca2_s284_wca1_wca2_csa32"> <start x="17584.0" y="1617.0"/> <end x="17619.0" y="1617.0"/> </arc> <arc class="stimulation" id="direct_43e54005-e409-468c-aacd-37ed46c5c087" source="wca1_s_wca2_s304_wca1_wca2_csa33" target="wca1_s_wca2_s80_wca1_wca2_sa62"> <start x="17486.0" y="1834.75"/> <end x="16577.027" y="984.0"/> </arc> <arc class="consumption" id="cons_6afceadf-3636-4856-b73b-34d992a25de9" source="wca1_s_wca2_s58_wca1_wca2_csa7" target="pr_585b60c2-d734-4c37-a34d-c35fc4e7432a_p1"> <start x="16977.0" y="858.0"/> <next x="17547.5" y="1647.0"/> <end x="17547.5" y="1664.5"/> </arc> <arc class="consumption" id="cons_f696563e-e6b4-4d0c-97ae-c009cf4a3ceb" source="wca1_s_wca2_s284_wca1_wca2_csa32" target="pr_585b60c2-d734-4c37-a34d-c35fc4e7432a_p1"> <start x="17619.0" y="1647.0"/> <next x="17547.5" y="1647.0"/> <end x="17547.5" y="1664.5"/> </arc> <arc class="production" id="prod_731dde6a-e1a2-4bc9-8fbb-710308d2e68a" source="pr_585b60c2-d734-4c37-a34d-c35fc4e7432a_p2" target="wca1_s_wca2_s304_wca1_wca2_csa33"> <start x="17547.5" y="1694.5"/> <end x="17547.5" y="1708.0"/> </arc> <arc class="consumption" id="cons_6c2500d5-e7f9-46b4-93e7-0bfc7d151816" source="wca1_s_wca2_s281_wca1_wca2_sa192" target="pr_ac06cfa1-1a43-4a2e-b780-8954ad0b9e3b_p1"> <start x="17620.0" y="1118.4381"/> <end x="16676.25" y="1488.469"/> </arc> <arc class="production" id="prod_2f896f16-b4b6-407d-aa50-2fec7d5671d1" source="pr_ac06cfa1-1a43-4a2e-b780-8954ad0b9e3b_p2" target="wca1_s_wca2_s136_wca1_wca2_sa105"> <start x="16646.25" y="1488.469"/> <end x="15702.5" y="1858.5"/> </arc> <arc class="consumption" id="cons_129ec132-0d29-4574-b1ca-830a0f8ce86d" source="wca1_s_wca2_s306_wca1_wca2_sa205" target="pr_ba99c462-2e56-4aa5-98dc-dfe37661cfa9_p1"> <start x="17688.0" y="1956.0"/> <end x="17688.0" y="1969.0"/> </arc> <arc class="production" id="prod_2093d5c9-1852-4aa0-988d-603b41b47a3d" source="pr_ba99c462-2e56-4aa5-98dc-dfe37661cfa9_p2" target="wca1_s_wca2_s308_wca1_wca2_sa206"> <start x="17688.0" y="1999.0"/> <end x="17688.0" y="2012.0"/> </arc> <arc class="catalysis" id="modif_0ca6159b-2def-462c-8e15-4f6b5e92390d" source="wca1_s_wca2_s309_wca1_wca2_sa207" target="pr_ba99c462-2e56-4aa5-98dc-dfe37661cfa9"> <start x="17554.0" y="1927.0"/> <end x="17683.0" y="1984.0"/> </arc> <arc class="consumption" id="cons_5d13a2f1-dc9c-4d9a-b47b-8af5ea56b3dc" source="wca1_s_wca2_s308_wca1_wca2_sa206" target="pr_8414d632-d39e-4c8d-8572-015bb4137476_p1"> <start x="17648.0" y="2032.0"/> <end x="17638.0" y="2032.5"/> </arc> <arc class="production" id="prod_6cdffa77-fdd5-4ef9-9d14-219b374c251c" source="pr_8414d632-d39e-4c8d-8572-015bb4137476_p2" target="wca1_s_wca2_s310_wca1_wca2_sa208"> <start x="17608.0" y="2032.5"/> <end x="17598.0" y="2033.0"/> </arc> <arc class="consumption" id="cons_b9a2b508-721f-427a-be8f-6a86f14cf4b9" source="wca1_s_wca2_s310_wca1_wca2_sa208" target="pr_1014e72d-b120-475f-a138-8170f64923b4_p1"> <start x="17518.0" y="2033.0"/> <end x="17496.0" y="2033.0"/> </arc> <arc class="production" id="prod_1916eb15-b5e5-427a-8c2f-33e4caefa53f" source="pr_1014e72d-b120-475f-a138-8170f64923b4_p2" target="wca1_s_wca2_s311_wca1_wca2_sa209"> <start x="17466.0" y="2033.0"/> <end x="17444.0" y="2033.0"/> </arc> <arc class="catalysis" id="modif_cc980e65-8d4c-4b3b-91ba-d3efd2542d71" source="wca1_s_wca2_s312_wca1_wca2_sa210" target="pr_1014e72d-b120-475f-a138-8170f64923b4"> <start x="17389.0" y="1947.0"/> <end x="17481.0" y="2028.0"/> </arc> <arc class="consumption" id="cons_22efc89a-7f42-421c-86f8-9eb779a199ba" source="wca1_s_wca2_s311_wca1_wca2_sa209" target="pr_3ca4e06a-76b7-4550-978b-00e745a924aa_p1"> <start x="17444.0" y="2013.0"/> <end x="17531.0" y="1969.5"/> </arc> <arc class="production" id="prod_f3d77703-edeb-4883-8fd7-ffb3e78fd9c2" source="pr_3ca4e06a-76b7-4550-978b-00e745a924aa_p2" target="wca1_s_wca2_s306_wca1_wca2_sa205"> <start x="17561.0" y="1969.5"/> <end x="17648.0" y="1926.0"/> </arc> <arc class="consumption" id="cons_3e9e2af9-2912-43be-b33f-2d03aa01c30b" source="wca1_s_wca2_s310_wca1_wca2_sa208" target="pr_b0e20ecf-83ee-4629-8b39-dee8057c7a5a_p1"> <start x="17558.0" y="2063.0"/> <end x="17559.674" y="2086.5"/> </arc> <arc class="production" id="prod_9049dbb6-d1f6-4701-9e3b-8c0e350414e1" source="pr_b0e20ecf-83ee-4629-8b39-dee8057c7a5a_p2" target="wca1_s_wca2_s313_wca1_wca2_sa211"> <start x="17559.674" y="2116.5"/> <end x="17561.348" y="2140.0"/> </arc> <arc class="consumption" id="cons_49d43e67-5d1c-4522-8169-f94cc7323f43" source="wca1_s_wca3_s1_wca1_wca3_sa1" target="pr_cc67526a-bb5c-4f40-8d2b-81fc44700324_p1"> <start x="13644.5" y="3557.0"/> <end x="13644.5" y="3591.5"/> </arc> <arc class="production" id="prod_462dd5d4-7055-4b25-8ff7-be24fbd05696" source="pr_cc67526a-bb5c-4f40-8d2b-81fc44700324_p2" target="wca1_s_wca3_s2_wca1_wca3_sa2"> <start x="13644.5" y="3621.5"/> <end x="13644.5" y="3656.0"/> </arc> <arc class="consumption" id="cons_6aefb953-683b-40ab-84d6-ee9c6958a1da" source="wca1_s_wca3_s2_wca1_wca3_sa2" target="pr_07f31a1d-98b9-4200-87ea-ea5e1cb1b91c_p1"> <start x="13684.5" y="3656.0"/> <end x="13684.5" y="3621.5"/> </arc> <arc class="production" id="prod_66cc2c4c-163f-4d6f-b9c0-18107ccb7e7b" source="pr_07f31a1d-98b9-4200-87ea-ea5e1cb1b91c_p2" target="wca1_s_wca3_s1_wca1_wca3_sa1"> <start x="13684.5" y="3591.5"/> <end x="13684.5" y="3557.0"/> </arc> <arc class="catalysis" id="modif_debb6685-0d6f-486b-8da0-5a47ee572102" source="wca1_s_wca3_s3_wca1_wca3_sa3" target="pr_07f31a1d-98b9-4200-87ea-ea5e1cb1b91c"> <start x="13753.829" y="3298.0"/> <end x="13689.5" y="3606.5"/> </arc> <arc class="consumption" id="cons_e035fb2a-28e4-43cf-a5b9-12901c4955bd" source="wca1_s_wca3_s4_wca1_wca3_sa4" target="pr_0ef7eb0a-bc85-47d0-84b9-007da4a66f57_p1"> <start x="13866.75" y="3511.0"/> <end x="13939.125" y="3569.0"/> </arc> <arc class="production" id="prod_d7b3db74-2277-4a9b-8d4d-fdebb40dc327" source="pr_0ef7eb0a-bc85-47d0-84b9-007da4a66f57_p2" target="wca1_s_wca3_s5_wca1_wca3_sa5"> <start x="13939.125" y="3599.0"/> <end x="14011.5" y="3657.0"/> </arc> <arc class="catalysis" id="modif_7b2a870a-43ad-47b6-a925-53fd5527b6b5" source="wca1_s_wca3_s3_wca1_wca3_sa3" target="pr_0ef7eb0a-bc85-47d0-84b9-007da4a66f57"> <start x="13758.0" y="3298.0"/> <end x="13942.676" y="3580.4797"/> </arc> <arc class="catalysis" id="modif_3600901b-809a-455b-b1dc-0ce97bd66591" source="wca1_s_wca3_s12_wca1_wca3_sa11" target="pr_0ef7eb0a-bc85-47d0-84b9-007da4a66f57"> <start x="13887.0" y="3812.0"/> <end x="13939.095" y="3591.071"/> </arc> <arc class="catalysis" id="modif_27f98495-9ef2-41a0-8f94-ad878a71d10c" source="wca1_s_wca3_s13_wca1_wca3_sa12" target="pr_0ef7eb0a-bc85-47d0-84b9-007da4a66f57"> <start x="13796.0" y="3670.0"/> <end x="13932.054" y="3583.9695"/> </arc> <arc class="consumption" id="cons_84d22513-d835-46ac-8231-e440e1a3450a" source="wca1_s_wca3_s14_wca1_wca3_sa13" target="pr_955da436-4b9b-48c3-90a9-d96a6b6d9f83_p1"> <start x="13756.0" y="3558.0"/> <end x="13756.0" y="3589.0"/> </arc> <arc class="production" id="prod_7f19235b-b511-46c2-b052-b40b131f046e" source="pr_955da436-4b9b-48c3-90a9-d96a6b6d9f83_p2" target="wca1_s_wca3_s13_wca1_wca3_sa12"> <start x="13756.0" y="3619.0"/> <end x="13756.0" y="3650.0"/> </arc> <arc class="catalysis" id="modif_6021fffd-07ec-4c45-8e66-6084e04d15f8" source="wca1_s_wca3_s12_wca1_wca3_sa11" target="pr_955da436-4b9b-48c3-90a9-d96a6b6d9f83"> <start x="13887.0" y="3812.0"/> <end x="13761.0" y="3604.0"/> </arc> <arc class="consumption" id="cons_10b53477-a383-46bd-ae21-e8132d0f2a29" source="wca1_s_wca3_s13_wca1_wca3_sa12" target="pr_00778628-edca-4d4f-815b-662104a7ba8e_p1"> <start x="13756.0" y="3690.0"/> <next x="14171.5" y="3770.0"/> <end x="14203.715" y="3790.8848"/> </arc> <arc class="consumption" id="cons_07af60dd-f9c5-4b25-b663-7d34857b6afa" source="wca1_s_wca3_s114_wca1_wca3_sa101" target="pr_00778628-edca-4d4f-815b-662104a7ba8e_p1"> <start x="14171.875" y="3696.0"/> <next x="14171.5" y="3770.0"/> <end x="14203.715" y="3790.8848"/> </arc> <arc class="production" id="prod_99158daa-27b7-4c36-acb1-508b1c2b0ea9" source="pr_00778628-edca-4d4f-815b-662104a7ba8e_p2" target="wca1_s_wca3_s15_wca1_wca3_csa8"> <start x="14233.715" y="3790.8848"/> <end x="14261.929" y="3810.0"/> </arc> <arc class="consumption" id="addreact_82eeabeb-2845-4af1-97db-f1f45399e11d" source="wca1_s_wca3_s12_wca1_wca3_sa11" target="pr_00778628-edca-4d4f-815b-662104a7ba8e_p1"> <start x="13927.0" y="3832.0"/> <end x="14203.715" y="3790.8848"/> </arc> <arc class="consumption" id="cons_991c446d-18a7-467d-8c33-74d7b52d7e25" source="wca1_s_wca3_s805_wca1_wca3_csa1" target="pr_01307c54-d634-4c00-bbd0-7f72914e500e_p1"> <start x="14223.4375" y="4419.625"/> <end x="14160.469" y="4459.875"/> </arc> <arc class="production" id="prod_3e3feef1-5106-48f6-a5bd-309b2c3e3498" source="pr_01307c54-d634-4c00-bbd0-7f72914e500e_p2" target="wca1_s_wca3_s705_wca1_wca3_csa3"> <start x="14130.469" y="4459.875"/> <end x="14067.5" y="4500.125"/> </arc> <arc class="consumption" id="addreact_1a7d7958-a17c-40e8-a420-fd2ad974a320" source="wca1_s_wca3_s687_wca1_wca3_csa71" target="pr_01307c54-d634-4c00-bbd0-7f72914e500e_p1"> <start x="13603.25" y="4277.0"/> <end x="14160.469" y="4459.875"/> </arc> <arc class="production" id="addprod_039f5e57-9bc4-4be3-bd2b-f238e15fc52e" source="pr_01307c54-d634-4c00-bbd0-7f72914e500e_p2" target="wca1_s_wca3_s29_wca1_wca3_csa4"> <start x="14130.469" y="4459.875"/> <end x="14017.4375" y="4823.0"/> </arc> <arc class="consumption" id="cons_5a8a0c43-fc23-43a3-9074-4619d788854f" source="wca1_s_wca3_s30_wca1_wca3_sa25" target="pr_219bb787-8e5d-4f7c-98bd-07c5a7261c25_p1"> <start x="14190.0" y="4566.0"/> <end x="14248.5" y="4566.922"/> </arc> <arc class="production" id="prod_821d7ec7-9f64-4f0a-9da6-b919f31dc000" source="pr_219bb787-8e5d-4f7c-98bd-07c5a7261c25_p2" target="wca1_s_wca3_s31_wca1_wca3_sa26"> <start x="14278.5" y="4566.922"/> <end x="14337.0" y="4567.8433"/> </arc> <arc class="inhibition" id="modif_df8527e7-1e1e-42b4-be76-0a4fc36b7c4c" source="wca1_s_wca3_s804_wca1_wca3_csa22" target="pr_219bb787-8e5d-4f7c-98bd-07c5a7261c25"> <start x="14467.0" y="4448.5"/> <end x="14263.5625" y="4561.9224"/> </arc> <arc class="catalysis" id="modif_a5125aa7-bdd2-47e7-895f-f4016aeb0d4c" source="wca1_s_wca3_s705_wca1_wca3_csa3" target="pr_219bb787-8e5d-4f7c-98bd-07c5a7261c25"> <start x="14067.5" y="4500.125"/> <end x="14258.563" y="4561.8594"/> </arc> <arc class="inhibition" id="modif_871903ff-517f-46a3-9569-ba0c0acc5a50" source="wca1_s_wca3_s491_wca1_wca3_csa59" target="pr_219bb787-8e5d-4f7c-98bd-07c5a7261c25"> <start x="14066.714" y="4015.5"/> <end x="14258.563" y="4561.8594"/> </arc> <arc class="consumption" id="cons_af18130a-4f57-4cf7-95e9-e4f307cf8db5" source="wca1_s_wca3_s73_wca1_wca3_sa65" target="pr_a6c63204-1637-44e1-996d-088e7575a883_p1"> <start x="15009.0" y="3676.0"/> <end x="14963.75" y="3676.0"/> </arc> <arc class="production" id="prod_aac9a6aa-8b19-4a1a-9355-a8e602e1469c" source="pr_a6c63204-1637-44e1-996d-088e7575a883_p2" target="wca1_s_wca3_s74_wca1_wca3_sa66"> <start x="14933.75" y="3676.0"/> <end x="14888.5" y="3676.0"/> </arc> <arc class="catalysis" id="modif_39f39a20-3e0d-4cdd-be76-bb59a2629d55" source="wca1_s_wca3_s75_wca1_wca3_sa67" target="pr_a6c63204-1637-44e1-996d-088e7575a883"> <start x="14950.0" y="3627.5"/> <end x="14948.75" y="3671.0"/> </arc> <arc class="consumption" id="cons_b1219420-abb7-4cfa-beb9-b1ec90769722" source="wca1_s_wca3_s15_wca1_wca3_csa8" target="pr_5765f480-91ba-41ee-bdde-8daf4c0d0e3f_p1"> <start x="14209.429" y="3897.5"/> <next x="13557.25" y="3758.0"/> <end x="13560.42" y="3764.5"/> </arc> <arc class="consumption" id="cons_f7ccc222-bbeb-44a5-a183-684114f68b50" source="wca1_s_wca3_s81_wca1_wca3_sa71" target="pr_5765f480-91ba-41ee-bdde-8daf4c0d0e3f_p1"> <start x="13492.8125" y="3729.0"/> <next x="13557.25" y="3758.0"/> <end x="13560.42" y="3764.5"/> </arc> <arc class="production" id="prod_aac52f76-f9c1-4f50-80eb-bd2d3fa4d009" source="pr_5765f480-91ba-41ee-bdde-8daf4c0d0e3f_p2" target="wca1_s_wca3_s85_wca1_wca3_csa2"> <start x="13560.42" y="3794.5"/> <end x="13563.0" y="3797.0"/> </arc> <arc class="consumption" id="cons_9c7628a4-a264-46f2-9dd8-3bb4183b4c13" source="wca1_s_wca3_s15_wca1_wca3_csa8" target="pr_2470ebb0-d90c-4dec-bfaa-8d8423e1ad9f_p1"> <start x="14314.429" y="3897.5"/> <next x="14821.5" y="3750.5"/> <end x="14886.92" y="3768.318"/> </arc> <arc class="consumption" id="cons_2742cc95-ec6e-4ac5-83d6-be9eb1d54ccd" source="wca1_s_wca3_s74_wca1_wca3_sa66" target="pr_2470ebb0-d90c-4dec-bfaa-8d8423e1ad9f_p1"> <start x="14848.5" y="3696.0"/> <next x="14821.5" y="3750.5"/> <end x="14886.92" y="3768.318"/> </arc> <arc class="production" id="prod_125ad6ea-de11-4e53-a86d-167333c92f3d" source="pr_2470ebb0-d90c-4dec-bfaa-8d8423e1ad9f_p2" target="wca1_s_wca3_s93_wca1_wca3_csa10"> <start x="14916.92" y="3768.318"/> <end x="14978.34" y="3785.25"/> </arc> <arc class="consumption" id="cons_154bd503-8dfa-469c-a901-9b893369cc29" source="wca1_s_wca3_s805_wca1_wca3_csa1" target="pr_e2ff787a-d263-40c3-8550-2a63446169ac_p1"> <start x="14273.9375" y="4513.125"/> <end x="14234.906" y="4593.125"/> </arc> <arc class="production" id="prod_b0ab529e-e079-4b3e-8d39-6c4985f70127" source="pr_e2ff787a-d263-40c3-8550-2a63446169ac_p2" target="wca1_s_wca3_s702_wca1_wca3_csa11"> <start x="14234.906" y="4623.125"/> <end x="14195.875" y="4703.125"/> </arc> <arc class="consumption" id="addreact_19ea2234-e41e-49aa-89e6-4c245537a17e" source="wca1_s_wca3_s696_wca1_wca3_csa72" target="pr_e2ff787a-d263-40c3-8550-2a63446169ac_p1"> <start x="14983.17" y="4270.5"/> <end x="14234.906" y="4593.125"/> </arc> <arc class="production" id="addprod_062ea8a2-13d3-4237-be7b-151d3d7d01bc" source="pr_e2ff787a-d263-40c3-8550-2a63446169ac_p2" target="wca1_s_wca3_s29_wca1_wca3_csa4"> <start x="14234.906" y="4623.125"/> <end x="14067.4375" y="4883.0"/> </arc> <arc class="consumption" id="cons_18486eaf-8ef5-4aa9-b47e-2248c4e62cc6" source="wca1_s_wca3_s5_wca1_wca3_sa5" target="pr_9b82b950-a463-49c5-b6bd-4c4eba5610dd_p1"> <start x="14051.5" y="3677.0"/> <end x="14076.6875" y="3676.5"/> </arc> <arc class="production" id="prod_2b5a4a82-f518-4d05-bdcc-7620b6111dcc" source="pr_9b82b950-a463-49c5-b6bd-4c4eba5610dd_p2" target="wca1_s_wca3_s114_wca1_wca3_sa101"> <start x="14106.6875" y="3676.5"/> <end x="14131.875" y="3676.0"/> </arc> <arc class="catalysis" id="modif_28a55756-aa77-424a-9da5-fb57c6a1b881" source="wca1_s_wca3_s116_wca1_wca3_sa103" target="pr_9b82b950-a463-49c5-b6bd-4c4eba5610dd"> <start x="14091.0" y="3722.0"/> <end x="14091.75" y="3681.4995"/> </arc> <arc class="consumption" id="cons_1ba80440-1db7-41fb-9afc-e3a6ec60dfcb" source="wca1_s_wca3_s137_wca1_wca3_sa105" target="pr_048190c0-e39b-4a47-b8b0-1e65216e5541_p1"> <start x="14525.5" y="4798.0"/> <end x="14486.25" y="4800.0"/> </arc> <arc class="production" id="prod_c4381312-e992-414c-96e0-1cde47c847eb" source="pr_048190c0-e39b-4a47-b8b0-1e65216e5541_p2" target="wca1_s_wca3_s136_wca1_wca3_sa104"> <start x="14456.25" y="4800.0"/> <end x="14417.0" y="4802.0"/> </arc> <arc class="catalysis" id="modif_605a60b1-7f73-4fe9-83c6-4da4b3b4f499" source="wca1_s_wca3_s138_wca1_wca3_sa106" target="pr_048190c0-e39b-4a47-b8b0-1e65216e5541"> <start x="14470.0" y="4881.0"/> <end x="14471.435" y="4804.9966"/> </arc> <arc class="consumption" id="cons_e0d7c6c9-4108-4aa7-9485-b8b43057e40b" source="wca1_s_wca3_s136_wca1_wca3_sa104" target="pr_ca18e887-f1c1-4d82-8223-298a1e897638_p1"> <start x="14417.0" y="4782.0"/> <end x="14456.25" y="4780.0"/> </arc> <arc class="production" id="prod_377bbd33-2eb8-4f23-bf4b-2dc68e67b8a3" source="pr_ca18e887-f1c1-4d82-8223-298a1e897638_p2" target="wca1_s_wca3_s137_wca1_wca3_sa105"> <start x="14486.25" y="4780.0"/> <end x="14525.5" y="4778.0"/> </arc> <arc class="catalysis" id="modif_fb495f15-6c2a-4940-bb22-f6d94ed610e5" source="wca1_s_wca3_s139_wca1_wca3_sa107" target="pr_ca18e887-f1c1-4d82-8223-298a1e897638"> <start x="14401.0" y="4738.0"/> <end x="14466.069" y="4775.1875"/> </arc> <arc class="catalysis" id="modif_285607bc-3042-46ea-a50e-e3e1797f4f19" source="wca1_s_wca3_s140_wca1_wca3_sa108" target="pr_ca18e887-f1c1-4d82-8223-298a1e897638"> <start x="14526.0" y="4738.0"/> <end x="14476.0625" y="4774.8193"/> </arc> <arc class="consumption" id="cons_f87d856c-e0e1-43cd-84bf-4dad6149b13e" source="wca1_s_wca3_s141_wca1_wca3_sa109" target="pr_ae61565d-f3a8-4daa-ad7a-9d0a1c8b40f3_p1"> <start x="13230.0" y="5230.0"/> <end x="13238.5" y="5230.0"/> </arc> <arc class="production" id="prod_24ed101d-999a-4488-bc99-189805e372e3" source="pr_ae61565d-f3a8-4daa-ad7a-9d0a1c8b40f3_p2" target="wca1_s_wca3_s142_wca1_wca3_sa110"> <start x="13268.5" y="5230.0"/> <end x="13277.0" y="5230.0"/> </arc> <arc class="inhibition" id="modif_8b8f961b-9634-407d-88b2-f07b1e8a9949" source="wca1_s_wca3_s143_wca1_wca3_sa111" target="pr_ae61565d-f3a8-4daa-ad7a-9d0a1c8b40f3"> <start x="13309.616" y="5263.0"/> <end x="13258.5" y="5235.0"/> </arc> <arc class="consumption" id="cons_2db56be5-5656-457d-9f53-bd4abae6810e" source="wca1_s_wca3_s145_wca1_wca3_sa112" target="pr_f93015ee-f81e-4eba-96cb-83244c8a549c_p1"> <start x="13155.0" y="3290.5"/> <next x="13231.0" y="3280.0"/> <end x="13265.5" y="3280.0"/> </arc> <arc class="consumption" id="cons_335a1e7e-b6cd-4c7b-8d42-2f22cd213ab2" source="wca1_s_wca3_s147_wca1_wca3_sa114" target="pr_f93015ee-f81e-4eba-96cb-83244c8a549c_p1"> <start x="13150.0" y="3344.0"/> <next x="13231.0" y="3280.0"/> <end x="13265.5" y="3280.0"/> </arc> <arc class="production" id="prod_99624553-68a6-4383-9107-0481c4bc1d77" source="pr_f93015ee-f81e-4eba-96cb-83244c8a549c_p2" target="wca1_s_wca3_s151_wca1_wca3_csa16"> <start x="13295.5" y="3280.0"/> <end x="13326.0" y="3280.0"/> </arc> <arc class="consumption" id="addreact_8f1ba812-c0b2-4448-a95c-fcb41962c81b" source="wca1_s_wca3_s146_wca1_wca3_sa113" target="pr_f93015ee-f81e-4eba-96cb-83244c8a549c_p1"> <start x="13257.141" y="3319.0"/> <end x="13265.5" y="3280.0"/> </arc> <arc class="stimulation" id="direct_0092df4e-e26b-45da-bf33-411e6a4401d9" source="wca1_s_wca3_s151_wca1_wca3_csa16" target="wca1_s_wca3_s170_wca1_wca3_csa18"> <start x="13428.0" y="3356.0"/> <end x="13452.0" y="3417.0"/> </arc> <arc class="consumption" id="cons_0325e5a1-e345-4baf-8fd8-581041e2fad5" source="wca1_s_wca3_s180_wca1_wca3_csa20" target="pr_043b5a24-d0ad-4ca2-95f3-66ba4b35c857_p1"> <start x="13752.0" y="3875.5"/> <next x="13803.0" y="3875.0"/> <end x="13818.0625" y="3913.5"/> </arc> <arc class="consumption" id="cons_f5aa1e1a-4e09-43d4-b58a-7b084727fe86" source="wca1_s_wca3_s165_wca1_wca3_sa133" target="pr_043b5a24-d0ad-4ca2-95f3-66ba4b35c857_p1"> <start x="13803.25" y="3771.2947"/> <next x="13803.0" y="3875.0"/> <end x="13818.0625" y="3913.5"/> </arc> <arc class="production" id="prod_747f5581-2fd6-4ae3-8ac6-334a37265116" source="pr_043b5a24-d0ad-4ca2-95f3-66ba4b35c857_p2" target="wca1_s_wca3_s156_wca1_wca3_csa17"> <start x="13818.0625" y="3943.5"/> <end x="13832.0" y="3978.0"/> </arc> <arc class="consumption" id="addreact_8a282924-3cac-4eda-bd0c-96afde1e01ea" source="wca1_s_wca3_s183_wca1_wca3_sa143" target="pr_043b5a24-d0ad-4ca2-95f3-66ba4b35c857_p1"> <start x="13741.0" y="3979.0"/> <end x="13818.0625" y="3913.5"/> </arc> <arc class="consumption" id="cons_5303b4f0-2544-4cbe-b14e-7c36bdc01d5a" source="wca1_s_wca3_s160_wca1_wca3_sa152" target="pr_c7b788b5-e136-40ee-b417-867e6d827042_p1"> <start x="14018.417" y="4161.5"/> <end x="13997.209" y="4161.5"/> </arc> <arc class="production" id="prod_20ff829c-38be-4331-aa0f-bdae0074e034" source="pr_c7b788b5-e136-40ee-b417-867e6d827042_p2" target="wca1_s_wca3_s161_wca1_wca3_sa126"> <start x="13967.209" y="4161.5"/> <end x="13946.0" y="4161.5"/> </arc> <arc class="catalysis" id="modif_a6155ab2-0d43-4028-9d1c-e8582b257bf5" source="wca1_s_wca3_s156_wca1_wca3_csa17" target="pr_c7b788b5-e136-40ee-b417-867e6d827042"> <start x="13940.0" y="3978.0"/> <end x="13982.209" y="4156.5"/> </arc> <arc class="consumption" id="cons_165b7249-0894-4543-ab33-92a558108d34" source="wca1_s_wca3_s162_wca1_wca3_sa128" target="pr_1eb3f718-9f4d-409b-8124-76d85422e9a8_p1"> <start x="14013.0" y="3386.232"/> <end x="14002.0" y="3387.732"/> </arc> <arc class="production" id="prod_d28f5e78-8198-48e5-b7ca-db7aa8f506d0" source="pr_1eb3f718-9f4d-409b-8124-76d85422e9a8_p2" target="wca1_s_wca3_s163_wca1_wca3_sa131"> <start x="13972.0" y="3387.732"/> <end x="13961.0" y="3389.232"/> </arc> <arc class="consumption" id="cons_c7bbc302-49b0-4a10-9bf6-006075eeb549" source="wca1_s_wca3_s163_wca1_wca3_sa131" target="pr_4b942c5d-a6a2-4eaf-899b-2acaebaac16d_p1"> <start x="13875.0" y="3389.232"/> <end x="13875.0" y="3389.232"/> </arc> <arc class="production" id="prod_0a550a61-c130-47a0-92c5-a2c7bf88fd28" source="pr_4b942c5d-a6a2-4eaf-899b-2acaebaac16d_p2" target="wca1_s_wca3_s164_wca1_wca3_sa132"> <start x="13845.0" y="3389.232"/> <end x="13845.0" y="3389.232"/> </arc> <arc class="necessary stimulation" id="modif_939adf10-4267-47c1-b4ed-27d059f589f9" source="wca1_s_wca3_s555_wca1_wca3_sa396" target="pr_4b942c5d-a6a2-4eaf-899b-2acaebaac16d"> <start x="13673.0" y="4040.0"/> <end x="13860.0" y="3394.232"/> </arc> <arc class="consumption" id="cons_0abca236-180f-4552-9185-e79d3731a187" source="wca1_s_wca3_s164_wca1_wca3_sa132" target="pr_72b4dc66-2696-47ab-ab2b-e5d1d9956d14_p1"> <start x="13802.075" y="3412.232"/> <end x="13802.625" y="3565.2632"/> </arc> <arc class="production" id="prod_2ee16f89-c5f1-41e4-bfda-483b0a705aca" source="pr_72b4dc66-2696-47ab-ab2b-e5d1d9956d14_p2" target="wca1_s_wca3_s165_wca1_wca3_sa133"> <start x="13802.625" y="3595.2632"/> <end x="13803.175" y="3748.2947"/> </arc> <arc class="consumption" id="cons_f2ce7dec-fa0e-486a-8562-06f41970447c" source="wca1_s_wca3_s153_wca1_wca3_sa135" target="pr_ae2c242f-2da6-4b78-a59f-a2ada73a9c94_p1"> <start x="13576.0" y="3395.5"/> <next x="13540.0" y="3448.75"/> <end x="13534.0" y="3464.3618"/> </arc> <arc class="consumption" id="cons_79c7c56a-2ceb-41ca-bf95-79e9b1f9b9db" source="wca1_s_wca3_s166_wca1_wca3_sa134" target="pr_ae2c242f-2da6-4b78-a59f-a2ada73a9c94_p1"> <start x="13580.0" y="3494.0"/> <next x="13540.0" y="3448.75"/> <end x="13534.0" y="3464.3618"/> </arc> <arc class="production" id="prod_b47b68f0-8ea2-4e25-ae79-038f613712b6" source="pr_ae2c242f-2da6-4b78-a59f-a2ada73a9c94_p2" target="wca1_s_wca3_s170_wca1_wca3_csa18"> <start x="13504.0" y="3464.3618"/> <end x="13502.0" y="3477.0"/> </arc> <arc class="consumption" id="cons_75738707-2165-4b33-8fc2-a494bc6de7cc" source="wca1_s_wca3_s170_wca1_wca3_csa18" target="pr_64a568a5-0810-4fac-bfc3-3b12456b4e1d_p1"> <start x="13402.0" y="3477.0"/> <end x="13387.0" y="3477.25"/> </arc> <arc class="production" id="prod_bf83a1b5-eac7-4e08-ab12-c0deacedffb1" source="pr_64a568a5-0810-4fac-bfc3-3b12456b4e1d_p2" target="wca1_s_wca3_s176_wca1_wca3_csa19"> <start x="13357.0" y="3477.25"/> <end x="13342.0" y="3477.5"/> </arc> <arc class="catalysis" id="modif_0d8d17f6-68b6-4f5a-88c4-fad49440f8c1" source="wca1_s_wca3_s170_wca1_wca3_csa18" target="pr_64a568a5-0810-4fac-bfc3-3b12456b4e1d"> <start x="13452.0" y="3417.0"/> <next x="13451.996" y="3414.9963"/> <next x="13371.846" y="3415.1533"/> <end x="13371.958" y="3472.2502"/> </arc> <arc class="consumption" id="cons_2f67e9d7-bbc5-4c7e-942b-34a00c44cd96" source="wca1_s_wca3_s161_wca1_wca3_sa126" target="pr_860ee03f-ecb3-4e4f-b329-8f7e3326c45e_p1"> <start x="13866.0" y="4161.5"/> <end x="13858.625" y="4161.5"/> </arc> <arc class="production" id="prod_ed06c291-2a07-4cde-8a46-e765030b7df9" source="pr_860ee03f-ecb3-4e4f-b329-8f7e3326c45e_p2" target="wca1_s_wca3_s188_wca1_wca3_sa145"> <start x="13828.625" y="4161.5"/> <end x="13821.25" y="4161.5"/> </arc> <arc class="catalysis" id="modif_5d32fcc4-c959-4afe-875a-4afda594db1b" source="wca1_s_wca3_s185_wca1_wca3_sa146" target="pr_860ee03f-ecb3-4e4f-b329-8f7e3326c45e"> <start x="13776.459" y="4208.0"/> <end x="13838.625" y="4166.5"/> </arc> <arc class="catalysis" id="modif_39e2d853-492c-4775-9505-422e0638076e" source="wca1_s_wca3_s608_wca1_wca3_sa147" target="pr_860ee03f-ecb3-4e4f-b329-8f7e3326c45e"> <start x="13844.216" y="4208.0"/> <end x="13843.625" y="4166.5"/> </arc> <arc class="catalysis" id="modif_dc2b8a6d-9764-4753-a3a0-975659cecfa7" source="wca1_s_wca3_s187_wca1_wca3_sa148" target="pr_860ee03f-ecb3-4e4f-b329-8f7e3326c45e"> <start x="13911.972" y="4208.0"/> <end x="13848.625" y="4166.5"/> </arc> <arc class="consumption" id="cons_71d28434-f251-4de6-b36e-b8082fda05da" source="wca1_s_wca3_s188_wca1_wca3_sa145" target="pr_f1c07362-77d4-4ec4-b3e8-c833fa69b7e3_p1"> <start x="13781.25" y="4141.5"/> <end x="13780.3545" y="4127.25"/> </arc> <arc class="production" id="prod_e61d7f7a-aa2d-4814-9ca5-f3d261cfe155" source="pr_f1c07362-77d4-4ec4-b3e8-c833fa69b7e3_p2" target="wca1_s_wca3_s189_wca1_wca3_sa149"> <start x="13780.3545" y="4097.25"/> <end x="13779.459" y="4083.0"/> </arc> <arc class="consumption" id="cons_c2ee399b-db4a-4d74-ad5d-faf4c4fde4bb" source="wca1_s_wca3_s160_wca1_wca3_sa152" target="pr_7718752b-9a45-427a-aa34-9cee41122e52_p1"> <start x="14058.417" y="4181.5"/> <next x="14151.406" y="4230.1997"/> <end x="14296.203" y="4246.048"/> </arc> <arc class="consumption" id="cons_365f36e9-75e8-4f35-b96f-e13ac761275c" source="wca1_s_wca3_s191_wca1_wca3_sa151" target="pr_7718752b-9a45-427a-aa34-9cee41122e52_p1"> <start x="14151.406" y="4181.5"/> <next x="14151.406" y="4230.1997"/> <end x="14296.203" y="4246.048"/> </arc> <arc class="production" id="prod_9e0f1428-fef1-4e5d-a242-ba7b43fe77a1" source="pr_7718752b-9a45-427a-aa34-9cee41122e52_p2" target="wca1_s_wca3_s804_wca1_wca3_csa22"> <start x="14326.203" y="4246.048"/> <end x="14467.0" y="4261.5"/> </arc> <arc class="consumption" id="addreact_7d44e3c7-7ebe-4ba8-9d65-9f560df4f38e" source="wca1_s_wca3_s190_wca1_wca3_sa150" target="pr_7718752b-9a45-427a-aa34-9cee41122e52_p1"> <start x="14243.417" y="4181.5"/> <end x="14296.203" y="4246.048"/> </arc> <arc class="consumption" id="addreact_cb5c42d8-9ac6-42b5-ba3e-57d2d0d24c84" source="wca1_s_wca3_s387_wca1_wca3_sa292" target="pr_7718752b-9a45-427a-aa34-9cee41122e52_p1"> <start x="14211.5" y="4049.5"/> <end x="14296.203" y="4246.048"/> </arc> <arc class="consumption" id="cons_672c7567-678e-4f25-92ac-9a16ccae4ea0" source="wca1_s_wca3_s190_wca1_wca3_sa150" target="pr_a3b3195c-d400-4e6a-9114-c038d93fc252_p1"> <start x="14283.417" y="4161.5"/> <end x="14303.541" y="4161.3613"/> </arc> <arc class="production" id="prod_a1a9b507-793d-46f8-be32-73f8afecf06a" source="pr_a3b3195c-d400-4e6a-9114-c038d93fc252_p2" target="wca1_s_wca3_s192_wca1_wca3_sa153"> <start x="14333.541" y="4161.3613"/> <end x="14353.666" y="4161.222"/> </arc> <arc class="catalysis" id="modif_8618edf2-c0dc-40e8-a886-6886eea62b63" source="wca1_s_wca3_s807_wca1_wca3_csa43" target="pr_a3b3195c-d400-4e6a-9114-c038d93fc252"> <start x="14318.0" y="4107.5"/> <end x="14318.521" y="4156.3613"/> </arc> <arc class="consumption" id="cons_f0b213ba-a4cf-40a4-86f2-05e2d3535ec7" source="wca1_s_wca3_s195_wca1_wca3_csa21" target="pr_203746b7-22d8-4627-8134-1140b8e5141d_p1"> <start x="14574.0" y="4013.0"/> <end x="14602.631" y="3988.0"/> </arc> <arc class="production" id="prod_8600a642-271e-45c8-b64e-86873b51c8d7" source="pr_203746b7-22d8-4627-8134-1140b8e5141d_p2" target="wca1_s_wca3_s198_wca1_wca3_sa158"> <start x="14602.631" y="3958.0"/> <end x="14631.263" y="3933.0"/> </arc> <arc class="consumption" id="cons_902fe2f4-c5f3-460d-885a-ac040e8aea56" source="wca1_s_wca3_s194_wca1_wca3_sa155" target="pr_c00f5402-28fd-4b6a-8297-b86ffacdaf20_p1"> <start x="14400.0" y="3973.0"/> <next x="14407.0" y="4014.0"/> <end x="14427.5" y="4013.4702"/> </arc> <arc class="consumption" id="cons_76c49c4c-a725-4ac3-82ad-fc2487916c18" source="wca1_s_wca3_s192_wca1_wca3_sa153" target="pr_c00f5402-28fd-4b6a-8297-b86ffacdaf20_p1"> <start x="14393.666" y="4141.222"/> <next x="14407.0" y="4014.0"/> <end x="14427.5" y="4013.4702"/> </arc> <arc class="production" id="prod_5e10b09f-ad0f-450c-9a95-4ebb7db8d1b2" source="pr_c00f5402-28fd-4b6a-8297-b86ffacdaf20_p2" target="wca1_s_wca3_s195_wca1_wca3_csa21"> <start x="14457.5" y="4013.4702"/> <end x="14474.0" y="4013.0"/> </arc> <arc class="consumption" id="cons_5cd754ee-e7a8-4972-8cfd-0bd7c91c5287" source="wca1_s_wca3_s199_wca1_wca3_sa159" target="pr_6a908394-b34a-49eb-a902-2a3c2f54cc1a_p1"> <start x="13230.0" y="5190.0"/> <end x="13238.5" y="5190.0"/> </arc> <arc class="production" id="prod_b6ec8ca8-1bb7-4f70-9827-25e6b540b4a8" source="pr_6a908394-b34a-49eb-a902-2a3c2f54cc1a_p2" target="wca1_s_wca3_s200_wca1_wca3_sa160"> <start x="13268.5" y="5190.0"/> <end x="13277.0" y="5190.0"/> </arc> <arc class="inhibition" id="modif_43d4b1b8-046d-4b97-bee1-a4e47676610d" source="wca1_s_wca3_s143_wca1_wca3_sa111" target="pr_6a908394-b34a-49eb-a902-2a3c2f54cc1a"> <start x="13321.909" y="5263.0"/> <end x="13253.5" y="5195.0"/> </arc> <arc class="consumption" id="cons_b6d6a5fe-7ba4-4c94-a85c-f668f82b5db8" source="wca1_s_wca3_s190_wca1_wca3_sa150" target="pr_94934c41-c78b-41c5-ace9-b1262dafd82d_p1"> <start x="14243.417" y="4181.5"/> <end x="14243.334" y="4210.25"/> </arc> <arc class="production" id="prod_6da8d754-b357-4bb4-a411-d23f266b8cd9" source="pr_94934c41-c78b-41c5-ace9-b1262dafd82d_p2" target="wca1_s_wca3_s202_wca1_wca3_sa166"> <start x="14243.334" y="4240.25"/> <end x="14243.25" y="4269.0"/> </arc> <arc class="catalysis" id="modif_a1513916-89a4-418a-9f47-958e87edfbb9" source="wca1_s_wca3_s201_wca1_wca3_sa161" target="pr_94934c41-c78b-41c5-ace9-b1262dafd82d"> <start x="14108.0" y="4244.0"/> <end x="14248.334" y="4225.26"/> </arc> <arc class="consumption" id="cons_a21d1605-02d6-421b-a85f-05a9c5aba095" source="wca1_s_wca3_s804_wca1_wca3_csa22" target="pr_32787b06-4358-4304-bd28-62e9021e1d6e_p1"> <start x="14416.5" y="4355.0"/> <end x="14385.469" y="4387.3125"/> </arc> <arc class="production" id="prod_47b7952e-4b76-4d8e-911c-150bb9deecc8" source="pr_32787b06-4358-4304-bd28-62e9021e1d6e_p2" target="wca1_s_wca3_s805_wca1_wca3_csa1"> <start x="14355.469" y="4387.3125"/> <end x="14324.4375" y="4419.625"/> </arc> <arc class="catalysis" id="logicarc_52ee6ece-691d-424d-b9a7-2d02534b68f0" source="logicglyph_2f0ecc5f-48c4-4a07-936a-11359edcaab0_p2" target="pr_32787b06-4358-4304-bd28-62e9021e1d6e"> <start x="14154.933" y="4343.246"/> <end x="14367.596" y="4383.22"/> </arc> <arc class="logic arc" id="modif_ec083be7-d66b-4704-ae99-376afbcaf385" source="wca1_s_wca3_s201_wca1_wca3_sa161" target="logicglyph_2f0ecc5f-48c4-4a07-936a-11359edcaab0_p1"> <start x="14068.0" y="4264.0"/> <end x="14114.933" y="4343.246"/> </arc> <arc class="logic arc" id="modif_ebbd56c1-7004-486c-a0d5-994f765b59b9" source="wca1_s_wca3_s213_wca1_wca3_sa167" target="logicglyph_2f0ecc5f-48c4-4a07-936a-11359edcaab0_p1"> <start x="14311.383" y="4247.0"/> <end x="14114.933" y="4343.246"/> </arc> <arc class="consumption" id="cons_cebd34b6-ebe6-46a0-b3ea-267f973c6411" source="wca1_s_wca3_s214_wca1_wca3_sa168" target="pr_277e1574-72fb-42c7-9a1a-7757e32cab30_p1"> <start x="13230.0" y="4781.0"/> <end x="13228.0" y="4781.0"/> </arc> <arc class="production" id="prod_d03e4056-31fc-4fb6-8035-6a790f42914a" source="pr_277e1574-72fb-42c7-9a1a-7757e32cab30_p2" target="wca1_s_wca3_s215_wca1_wca3_sa169"> <start x="13258.0" y="4781.0"/> <end x="13256.0" y="4781.0"/> </arc> <arc class="catalysis" id="modif_5cd254e0-edc4-4ca1-82e1-c4a0041a62b7" source="wca1_s_wca3_s220_wca1_wca3_sa174" target="pr_277e1574-72fb-42c7-9a1a-7757e32cab30"> <start x="13337.0" y="4732.0"/> <end x="13243.0" y="4776.0"/> </arc> <arc class="consumption" id="cons_6f8ff8ba-a488-41f4-890e-9dcf0b7f6bf5" source="wca1_s_wca3_s216_wca1_wca3_sa170" target="pr_b657dc65-fbaa-491b-829f-60e1eed514ec_p1"> <start x="13230.0" y="4814.7144"/> <end x="13228.0" y="4814.642"/> </arc> <arc class="production" id="prod_49a3cf8b-9d6c-4cf1-854d-18588785eb25" source="pr_b657dc65-fbaa-491b-829f-60e1eed514ec_p2" target="wca1_s_wca3_s217_wca1_wca3_sa171"> <start x="13258.0" y="4814.642"/> <end x="13256.0" y="4814.57"/> </arc> <arc class="catalysis" id="modif_7b73ecf4-2173-493e-a766-cc0b8b6b4ad9" source="wca1_s_wca3_s220_wca1_wca3_sa174" target="pr_b657dc65-fbaa-491b-829f-60e1eed514ec"> <start x="13337.0" y="4732.0"/> <end x="13242.973" y="4809.642"/> </arc> <arc class="consumption" id="cons_0bfdb752-4dea-43aa-a18e-06d380e27219" source="wca1_s_wca3_s218_wca1_wca3_sa172" target="pr_3c14cd2f-d5d1-4a88-b82b-31972276061b_p1"> <start x="13230.0" y="4848.4287"/> <end x="13230.25" y="4848.2764"/> </arc> <arc class="production" id="prod_eb2d11f7-47f7-41c6-9fd7-c2f787ac1c44" source="pr_3c14cd2f-d5d1-4a88-b82b-31972276061b_p2" target="wca1_s_wca3_s219_wca1_wca3_sa173"> <start x="13260.25" y="4848.2764"/> <end x="13260.5" y="4848.1245"/> </arc> <arc class="catalysis" id="modif_bb5e6150-5899-4f50-84ef-6bc3d388c08b" source="wca1_s_wca3_s220_wca1_wca3_sa174" target="pr_3c14cd2f-d5d1-4a88-b82b-31972276061b"> <start x="13337.0" y="4732.0"/> <end x="13245.2" y="4843.277"/> </arc> <arc class="consumption" id="cons_8e14688a-1c97-447b-884d-c3263b6533dc" source="wca1_s_wca3_s237_wca1_wca3_sa185" target="pr_89dc7727-ae3b-476e-90c0-bb814ea3b060_p1"> <start x="13230.0" y="4882.1426"/> <end x="13230.25" y="4882.1426"/> </arc> <arc class="production" id="prod_294bcd05-60c8-4f20-9aaf-2a369425751a" source="pr_89dc7727-ae3b-476e-90c0-bb814ea3b060_p2" target="wca1_s_wca3_s242_wca1_wca3_sa190"> <start x="13260.25" y="4882.1426"/> <end x="13260.5" y="4882.1426"/> </arc> <arc class="inhibition" id="modif_c6fa1a4b-0eed-412c-810e-75e0fc654eaa" source="wca1_s_wca3_s799_wca1_wca3_csa60" target="pr_89dc7727-ae3b-476e-90c0-bb814ea3b060"> <start x="14182.0" y="5053.5"/> <end x="13245.25" y="4887.1426"/> </arc> <arc class="catalysis" id="modif_41832c74-cbd1-4015-8373-89e9189f26da" source="wca1_s_wca3_s800_wca1_wca3_csa7" target="pr_89dc7727-ae3b-476e-90c0-bb814ea3b060"> <start x="14386.0" y="5042.0"/> <end x="13245.25" y="4877.1426"/> </arc> <arc class="consumption" id="cons_917cfed4-01b7-4e83-8d30-cc247636cd45" source="wca1_s_wca3_s238_wca1_wca3_sa186" target="pr_654996f9-76a3-45a3-b7ae-914a0b181510_p1"> <start x="13230.0" y="4915.8574"/> <end x="13230.25" y="4915.8574"/> </arc> <arc class="production" id="prod_08f0402d-e1de-439b-8628-1e9c9cfe689c" source="pr_654996f9-76a3-45a3-b7ae-914a0b181510_p2" target="wca1_s_wca3_s243_wca1_wca3_sa191"> <start x="13260.25" y="4915.8574"/> <end x="13260.5" y="4915.8574"/> </arc> <arc class="catalysis" id="modif_d02f1bd0-b717-4b4d-91f8-4ca17f9757fb" source="wca1_s_wca3_s536_wca1_wca3_csa62" target="pr_654996f9-76a3-45a3-b7ae-914a0b181510"> <start x="13894.0" y="5212.0"/> <end x="13245.25" y="4920.8574"/> </arc> <arc class="consumption" id="cons_37b9852c-ac6b-43c6-8223-f35d58f10326" source="wca1_s_wca3_s239_wca1_wca3_sa187" target="pr_be06013c-b7b0-4227-914c-9ec6e7e591b0_p1"> <start x="13230.0" y="4949.5713"/> <end x="13230.25" y="4949.5713"/> </arc> <arc class="production" id="prod_07e21a62-3a5d-4498-bf0b-96c5a7f1b88a" source="pr_be06013c-b7b0-4227-914c-9ec6e7e591b0_p2" target="wca1_s_wca3_s244_wca1_wca3_sa192"> <start x="13260.25" y="4949.5713"/> <end x="13260.5" y="4949.5713"/> </arc> <arc class="consumption" id="cons_f75a27a9-aaec-4d14-a0d2-2faedb710d04" source="wca1_s_wca3_s240_wca1_wca3_sa188" target="pr_bc81ae53-0798-415e-af19-3d0c2b73f15d_p1"> <start x="13230.0" y="4983.2856"/> <end x="13230.25" y="4983.2856"/> </arc> <arc class="production" id="prod_b0648241-3f34-47a6-86d1-2a60f44d94d6" source="pr_bc81ae53-0798-415e-af19-3d0c2b73f15d_p2" target="wca1_s_wca3_s245_wca1_wca3_sa193"> <start x="13260.25" y="4983.2856"/> <end x="13260.5" y="4983.2856"/> </arc> <arc class="consumption" id="cons_db58af6f-6a3d-4c64-82e1-a82bd6a9ea6e" source="wca1_s_wca3_s241_wca1_wca3_sa189" target="pr_d13280d9-b142-42ba-b620-313d2d51a186_p1"> <start x="13230.0" y="5017.0"/> <end x="13230.25" y="5017.0"/> </arc> <arc class="production" id="prod_b8975a26-8de5-4f24-8d50-b512c6afb74d" source="pr_d13280d9-b142-42ba-b620-313d2d51a186_p2" target="wca1_s_wca3_s246_wca1_wca3_sa194"> <start x="13260.25" y="5017.0"/> <end x="13260.5" y="5017.0"/> </arc> <arc class="consumption" id="cons_0f693aba-e852-4494-b95e-74c15c0731f4" source="wca1_s_wca3_s215_wca1_wca3_sa169" target="pr_800ceaca-7667-4011-b096-ece849ac9101_p1"> <start x="13333.5" y="4781.0"/> <next x="13363.5" y="4780.5"/> <end x="13373.94" y="4765.25"/> </arc> <arc class="consumption" id="cons_666b6889-807e-4cdb-980e-fe624bfa8469" source="wca1_s_wca3_s242_wca1_wca3_sa190" target="pr_800ceaca-7667-4011-b096-ece849ac9101_p1"> <start x="13338.0" y="4882.1426"/> <next x="13363.5" y="4780.5"/> <end x="13373.94" y="4765.25"/> </arc> <arc class="production" id="prod_9e80d2c0-b628-4b9d-b7b5-65e5313f3a69" source="pr_800ceaca-7667-4011-b096-ece849ac9101_p2" target="wca1_s_wca3_s234_wca1_wca3_csa26"> <start x="13373.94" y="4735.25"/> <end x="13383.0" y="4724.0"/> </arc> <arc class="consumption" id="cons_d242e189-aac2-4e0b-8f80-641fa634a9e6" source="wca1_s_wca3_s217_wca1_wca3_sa171" target="pr_95d82af5-08df-4e05-b145-979a842bc38a_p1"> <start x="13333.5" y="4814.5"/> <next x="13363.5" y="4814.5"/> <end x="13373.682" y="4782.25"/> </arc> <arc class="consumption" id="cons_7ae57916-6674-4bb4-b2fa-05965f36b138" source="wca1_s_wca3_s242_wca1_wca3_sa190" target="pr_95d82af5-08df-4e05-b145-979a842bc38a_p1"> <start x="13338.0" y="4882.1426"/> <next x="13363.5" y="4814.5"/> <end x="13373.682" y="4782.25"/> </arc> <arc class="production" id="prod_ee21e707-362b-4f3a-a5ff-e033e35b0688" source="pr_95d82af5-08df-4e05-b145-979a842bc38a_p2" target="wca1_s_wca3_s234_wca1_wca3_csa26"> <start x="13373.682" y="4752.25"/> <end x="13383.0" y="4724.0"/> </arc> <arc class="consumption" id="cons_64672e14-ac76-4e99-87dd-f28cbee17b12" source="wca1_s_wca3_s219_wca1_wca3_sa173" target="pr_6b61a04b-4d56-46f4-b5c5-c43ac2caa6ff_p1"> <start x="13338.0" y="4848.0"/> <next x="13364.0" y="4858.4995"/> <end x="13373.783" y="4804.25"/> </arc> <arc class="consumption" id="cons_e1c9b099-358b-43f6-9fb6-262c5a386cec" source="wca1_s_wca3_s242_wca1_wca3_sa190" target="pr_6b61a04b-4d56-46f4-b5c5-c43ac2caa6ff_p1"> <start x="13338.0" y="4882.1426"/> <next x="13364.0" y="4858.4995"/> <end x="13373.783" y="4804.25"/> </arc> <arc class="production" id="prod_945621ee-20b8-46e4-b616-886ddd99780a" source="pr_6b61a04b-4d56-46f4-b5c5-c43ac2caa6ff_p2" target="wca1_s_wca3_s234_wca1_wca3_csa26"> <start x="13373.783" y="4774.25"/> <end x="13383.0" y="4724.0"/> </arc> <arc class="consumption" id="cons_412656dc-7b14-4623-801d-10aa36264798" source="wca1_s_wca3_s215_wca1_wca3_sa169" target="pr_663779fe-f2e8-4e13-b506-747159456abd_p1"> <start x="13333.5" y="4781.0"/> <next x="13358.0" y="4780.5"/> <end x="13418.5" y="4751.4814"/> </arc> <arc class="consumption" id="cons_9de2f227-8d9f-4273-98f8-3f34d610e8c5" source="wca1_s_wca3_s243_wca1_wca3_sa191" target="pr_663779fe-f2e8-4e13-b506-747159456abd_p1"> <start x="13338.0" y="4915.8574"/> <next x="13358.0" y="4780.5"/> <end x="13418.5" y="4751.4814"/> </arc> <arc class="production" id="prod_3a5c15ae-80fd-4418-bb1d-31e70f524ac3" source="pr_663779fe-f2e8-4e13-b506-747159456abd_p2" target="wca1_s_wca3_s232_wca1_wca3_csa25"> <start x="13448.5" y="4751.4814"/> <end x="13505.0" y="4724.0"/> </arc> <arc class="consumption" id="cons_f55b0112-e768-4017-9df2-d844bac8190b" source="wca1_s_wca3_s217_wca1_wca3_sa171" target="pr_5671497e-9189-44b4-afab-7ef7e7af2d86_p1"> <start x="13333.5" y="4814.5"/> <next x="13358.0" y="4814.5"/> <end x="13418.5" y="4768.0186"/> </arc> <arc class="consumption" id="cons_db6c0353-abce-491c-b0ff-2b3c09fb2b96" source="wca1_s_wca3_s243_wca1_wca3_sa191" target="pr_5671497e-9189-44b4-afab-7ef7e7af2d86_p1"> <start x="13338.0" y="4915.8574"/> <next x="13358.0" y="4814.5"/> <end x="13418.5" y="4768.0186"/> </arc> <arc class="production" id="prod_b89e083a-846e-4f0b-b47e-9241f881df6f" source="pr_5671497e-9189-44b4-afab-7ef7e7af2d86_p2" target="wca1_s_wca3_s232_wca1_wca3_csa25"> <start x="13448.5" y="4768.0186"/> <end x="13505.0" y="4724.0"/> </arc> <arc class="consumption" id="cons_2b218c73-34de-4eee-a61d-bfa9a76b13ef" source="wca1_s_wca3_s219_wca1_wca3_sa173" target="pr_c5ba55df-a604-4fcd-a058-c653db033ee7_p1"> <start x="13338.0" y="4848.0"/> <next x="13360.0" y="4847.5"/> <end x="13419.5" y="4784.047"/> </arc> <arc class="consumption" id="cons_3dc88e16-a185-4681-b4b0-a6706e562107" source="wca1_s_wca3_s243_wca1_wca3_sa191" target="pr_c5ba55df-a604-4fcd-a058-c653db033ee7_p1"> <start x="13338.0" y="4915.8574"/> <next x="13360.0" y="4847.5"/> <end x="13419.5" y="4784.047"/> </arc> <arc class="production" id="prod_d76e4976-8e8d-4792-97a3-49f1ee50a152" source="pr_c5ba55df-a604-4fcd-a058-c653db033ee7_p2" target="wca1_s_wca3_s232_wca1_wca3_csa25"> <start x="13449.5" y="4784.047"/> <end x="13505.0" y="4724.0"/> </arc> <arc class="consumption" id="cons_db96483b-dc45-4eda-894e-878da21f7474" source="wca1_s_wca3_s215_wca1_wca3_sa169" target="pr_1109e70e-223a-4c4e-9c40-b7a917793aae_p1"> <start x="13333.5" y="4781.0"/> <next x="13424.5" y="4863.0"/> <end x="13451.25" y="4864.0503"/> </arc> <arc class="consumption" id="cons_3a21f8ac-6be0-4b6a-a3a1-de324dc9d3de" source="wca1_s_wca3_s244_wca1_wca3_sa192" target="pr_1109e70e-223a-4c4e-9c40-b7a917793aae_p1"> <start x="13338.0" y="4949.5713"/> <next x="13424.5" y="4863.0"/> <end x="13451.25" y="4864.0503"/> </arc> <arc class="production" id="prod_815e8bae-4a77-4325-a2e5-c5ac89593d1c" source="pr_1109e70e-223a-4c4e-9c40-b7a917793aae_p2" target="wca1_s_wca3_s230_wca1_wca3_csa24"> <start x="13481.25" y="4864.0503"/> <end x="13504.0" y="4865.0"/> </arc> <arc class="consumption" id="cons_e7b6d59a-9358-4a91-a8f5-63f4c89231b5" source="wca1_s_wca3_s217_wca1_wca3_sa171" target="pr_3c25bff3-e37a-4229-a5ab-31f8f12877ee_p1"> <start x="13333.5" y="4814.5"/> <next x="13424.5" y="4863.0"/> <end x="13451.25" y="4864.0503"/> </arc> <arc class="consumption" id="cons_fb521128-1880-44d6-b006-f53d9dc13bc0" source="wca1_s_wca3_s244_wca1_wca3_sa192" target="pr_3c25bff3-e37a-4229-a5ab-31f8f12877ee_p1"> <start x="13338.0" y="4949.5713"/> <next x="13424.5" y="4863.0"/> <end x="13451.25" y="4864.0503"/> </arc> <arc class="production" id="prod_2286493f-f06a-42ca-8579-18f70c90b09d" source="pr_3c25bff3-e37a-4229-a5ab-31f8f12877ee_p2" target="wca1_s_wca3_s230_wca1_wca3_csa24"> <start x="13481.25" y="4864.0503"/> <end x="13504.0" y="4865.0"/> </arc> <arc class="consumption" id="cons_2651b46e-a94d-49e2-8d1e-565f72148491" source="wca1_s_wca3_s219_wca1_wca3_sa173" target="pr_35d3e7f7-7c6d-4e2b-96a7-b7ea82590e43_p1"> <start x="13338.0" y="4848.0"/> <next x="13382.5" y="4863.0"/> <end x="13430.25" y="4864.033"/> </arc> <arc class="consumption" id="cons_24ce9c3a-8c41-458e-aac4-06525528297e" source="wca1_s_wca3_s244_wca1_wca3_sa192" target="pr_35d3e7f7-7c6d-4e2b-96a7-b7ea82590e43_p1"> <start x="13338.0" y="4949.5713"/> <next x="13382.5" y="4863.0"/> <end x="13430.25" y="4864.033"/> </arc> <arc class="production" id="prod_b2f474b6-adb0-48e6-b87e-64dd14fe24c9" source="pr_35d3e7f7-7c6d-4e2b-96a7-b7ea82590e43_p2" target="wca1_s_wca3_s230_wca1_wca3_csa24"> <start x="13460.25" y="4864.033"/> <end x="13504.0" y="4865.0"/> </arc> <arc class="consumption" id="cons_ef2b5f17-62cf-4c61-9588-d44221ad728e" source="wca1_s_wca3_s215_wca1_wca3_sa169" target="pr_0f256917-0a63-48e7-bf27-b4b431fee32b_p1"> <start x="13333.5" y="4781.0"/> <next x="13369.5" y="4982.5"/> <end x="13377.992" y="4977.25"/> </arc> <arc class="consumption" id="cons_d9a1cbd8-08e9-47b3-93ea-40bf0684482f" source="wca1_s_wca3_s245_wca1_wca3_sa193" target="pr_0f256917-0a63-48e7-bf27-b4b431fee32b_p1"> <start x="13338.0" y="4983.2856"/> <next x="13369.5" y="4982.5"/> <end x="13377.992" y="4977.25"/> </arc> <arc class="production" id="prod_279668a1-64d4-4b46-95c3-ea0175a994d1" source="pr_0f256917-0a63-48e7-bf27-b4b431fee32b_p2" target="wca1_s_wca3_s228_wca1_wca3_csa23"> <start x="13377.992" y="5007.25"/> <end x="13383.0" y="4998.0"/> </arc> <arc class="consumption" id="cons_e6dd658c-a30e-45d3-924e-0b26b14749ab" source="wca1_s_wca3_s217_wca1_wca3_sa171" target="pr_cbc333fd-1209-46a1-b348-f70634d3a15e_p1"> <start x="13333.5" y="4814.5"/> <next x="13367.5" y="4982.5"/> <end x="13377.25" y="4977.25"/> </arc> <arc class="consumption" id="cons_fb994570-b256-481b-a4b5-eb41bda1791f" source="wca1_s_wca3_s245_wca1_wca3_sa193" target="pr_cbc333fd-1209-46a1-b348-f70634d3a15e_p1"> <start x="13338.0" y="4983.2856"/> <next x="13367.5" y="4982.5"/> <end x="13377.25" y="4977.25"/> </arc> <arc class="production" id="prod_0fb950d7-a924-49e7-8ab8-d5ec7785d543" source="pr_cbc333fd-1209-46a1-b348-f70634d3a15e_p2" target="wca1_s_wca3_s228_wca1_wca3_csa23"> <start x="13377.25" y="5007.25"/> <end x="13383.0" y="4998.0"/> </arc> <arc class="consumption" id="cons_40ae3830-7d06-4153-8181-736f07258387" source="wca1_s_wca3_s219_wca1_wca3_sa173" target="pr_bb782d5b-58d5-4ae0-9ed4-3bbe97aa9606_p1"> <start x="13338.0" y="4848.0"/> <next x="13367.5" y="4982.5"/> <end x="13377.25" y="4977.25"/> </arc> <arc class="consumption" id="cons_e579e7c8-a5e0-4e7c-8e35-e6f464288152" source="wca1_s_wca3_s245_wca1_wca3_sa193" target="pr_bb782d5b-58d5-4ae0-9ed4-3bbe97aa9606_p1"> <start x="13338.0" y="4983.2856"/> <next x="13367.5" y="4982.5"/> <end x="13377.25" y="4977.25"/> </arc> <arc class="production" id="prod_6d7f3707-66da-4364-a78b-ffcb39cbda92" source="pr_bb782d5b-58d5-4ae0-9ed4-3bbe97aa9606_p2" target="wca1_s_wca3_s228_wca1_wca3_csa23"> <start x="13377.25" y="5007.25"/> <end x="13383.0" y="4998.0"/> </arc> <arc class="consumption" id="cons_83e21b14-2073-4119-9928-a0dee4619bf6" source="wca1_s_wca3_s215_wca1_wca3_sa169" target="pr_ac2d9d1d-aff7-4c07-9e1e-847f25cb148f_p1"> <start x="13333.5" y="4781.0"/> <next x="13363.5" y="4863.0"/> <end x="13360.25" y="4863.0"/> </arc> <arc class="consumption" id="cons_fcc83055-0b2b-467e-a2d1-1f7072119f0d" source="wca1_s_wca3_s246_wca1_wca3_sa194" target="pr_ac2d9d1d-aff7-4c07-9e1e-847f25cb148f_p1"> <start x="13338.0" y="5017.0"/> <next x="13363.5" y="4863.0"/> <end x="13360.25" y="4863.0"/> </arc> <arc class="production" id="prod_2625f0d3-6847-4081-883d-b517ff37f2a1" source="pr_ac2d9d1d-aff7-4c07-9e1e-847f25cb148f_p2" target="wca1_s_wca3_s236_wca1_wca3_csa27"> <start x="13390.25" y="4863.0"/> <end x="13383.0" y="4863.0"/> </arc> <arc class="consumption" id="cons_3dc52a07-fb6f-4fe5-bc01-9af2ef799da6" source="wca1_s_wca3_s217_wca1_wca3_sa171" target="pr_111deaf0-2dfe-4cb6-814a-eac46e8b16f4_p1"> <start x="13333.5" y="4814.5"/> <next x="13363.5" y="4863.0"/> <end x="13360.25" y="4863.0"/> </arc> <arc class="consumption" id="cons_3aa3e739-38d6-4b11-a4ec-b2186229677a" source="wca1_s_wca3_s246_wca1_wca3_sa194" target="pr_111deaf0-2dfe-4cb6-814a-eac46e8b16f4_p1"> <start x="13338.0" y="5017.0"/> <next x="13363.5" y="4863.0"/> <end x="13360.25" y="4863.0"/> </arc> <arc class="production" id="prod_42baed71-261f-421e-9c05-886402df1538" source="pr_111deaf0-2dfe-4cb6-814a-eac46e8b16f4_p2" target="wca1_s_wca3_s236_wca1_wca3_csa27"> <start x="13390.25" y="4863.0"/> <end x="13383.0" y="4863.0"/> </arc> <arc class="consumption" id="cons_5a77dd61-6586-41c0-ade5-6c243d8a2033" source="wca1_s_wca3_s219_wca1_wca3_sa173" target="pr_0ea61d60-9802-40e7-9f93-49934ad1b7fc_p1"> <start x="13338.0" y="4848.0"/> <next x="13364.0" y="4863.0"/> <end x="13360.5" y="4863.0"/> </arc> <arc class="consumption" id="cons_ac535e3c-718e-4358-b5d0-69eda72b4c95" source="wca1_s_wca3_s246_wca1_wca3_sa194" target="pr_0ea61d60-9802-40e7-9f93-49934ad1b7fc_p1"> <start x="13338.0" y="5017.0"/> <next x="13364.0" y="4863.0"/> <end x="13360.5" y="4863.0"/> </arc> <arc class="production" id="prod_b9b9a2e2-d79f-4033-bde8-fb65c6fd1428" source="pr_0ea61d60-9802-40e7-9f93-49934ad1b7fc_p2" target="wca1_s_wca3_s236_wca1_wca3_csa27"> <start x="13390.5" y="4863.0"/> <end x="13383.0" y="4863.0"/> </arc> <arc class="consumption" id="cons_adf1451a-5c9e-41af-bac0-a20ca4ff9705" source="wca1_s_wca3_s85_wca1_wca3_csa2" target="pr_e42ab99b-810a-4f78-8d14-fb0b713d74d7_p1"> <start x="13615.5" y="4014.0"/> <next x="14744.0" y="3988.0"/> <end x="14751.279" y="4000.5"/> </arc> <arc class="consumption" id="cons_9e8a49e7-2997-4127-81c3-0d347c4f57f2" source="wca1_s_wca3_s247_wca1_wca3_sa195" target="pr_e42ab99b-810a-4f78-8d14-fb0b713d74d7_p1"> <start x="14744.0" y="3929.0"/> <next x="14744.0" y="3988.0"/> <end x="14751.279" y="4000.5"/> </arc> <arc class="production" id="prod_94db96c2-0b01-4a57-9984-6fab392a9d74" source="pr_e42ab99b-810a-4f78-8d14-fb0b713d74d7_p2" target="wca1_s_wca3_s257_wca1_wca3_csa28"> <start x="14751.279" y="4030.5"/> <end x="14757.5" y="4039.0"/> </arc> <arc class="consumption" id="cons_949dad88-1a29-4690-87db-6262d0ac1672" source="wca1_s_wca3_s258_wca1_wca3_sa205" target="pr_bdd7f8b7-6e70-456c-8157-5d4bd140b9f6_p1"> <start x="14815.0" y="4409.0"/> <end x="14830.5" y="4409.0"/> </arc> <arc class="production" id="prod_567e0ee6-4dcd-477f-8ed0-f170db5e69cd" source="pr_bdd7f8b7-6e70-456c-8157-5d4bd140b9f6_p2" target="wca1_s_wca3_s259_wca1_wca3_sa206"> <start x="14860.5" y="4409.0"/> <end x="14876.0" y="4409.0"/> </arc> <arc class="catalysis" id="modif_84bef636-ad5b-4961-88dc-d3a53a7119ea" source="wca1_s_wca3_s257_wca1_wca3_csa28" target="pr_bdd7f8b7-6e70-456c-8157-5d4bd140b9f6"> <start x="14701.75" y="4171.0"/> <end x="14850.5" y="4404.0"/> </arc> <arc class="inhibition" id="modif_c49c21ca-f8d7-4d92-b754-1b52415366c9" source="wca1_s_wca3_s247_wca1_wca3_sa195" target="pr_bdd7f8b7-6e70-456c-8157-5d4bd140b9f6"> <start x="14744.0" y="3929.0"/> <end x="14845.5" y="4404.0"/> </arc> <arc class="catalysis" id="modif_e3b7c1bf-4e35-4478-a29a-46d0b1fb6047" source="wca1_s_wca3_s705_wca1_wca3_csa3" target="pr_bdd7f8b7-6e70-456c-8157-5d4bd140b9f6"> <start x="14067.5" y="4500.125"/> <end x="14840.5" y="4404.0"/> </arc> <arc class="catalysis" id="modif_5b89a0e7-bc3f-4676-85ca-00f32fc031d0" source="wca1_s_wca3_s476_wca1_wca3_csa58" target="pr_bdd7f8b7-6e70-456c-8157-5d4bd140b9f6"> <start x="13749.8125" y="4533.0"/> <end x="14840.5" y="4414.0"/> </arc> <arc class="inhibition" id="modif_acbbe96c-0dd3-4bac-bb66-de90287eaeaa" source="wca1_s_wca3_s799_wca1_wca3_csa60" target="pr_bdd7f8b7-6e70-456c-8157-5d4bd140b9f6"> <start x="14273.0" y="4968.0"/> <end x="14845.5" y="4414.0"/> </arc> <arc class="stimulation" id="direct_3b34b1cc-ec66-4c1b-8721-af41314b6743" source="wca1_s_wca3_s260_wca1_wca3_sa207" target="wca1_s_wca3_s247_wca1_wca3_sa195"> <start x="14652.314" y="4015.0"/> <end x="14704.0" y="3909.0"/> </arc> <arc class="consumption" id="cons_ae36ac83-3f76-44bd-8286-dfda19957fd3" source="wca1_s_wca3_s5_wca1_wca3_sa5" target="pr_c7abb1f4-b911-4ec5-98fb-51a43901919a_p1"> <start x="14051.5" y="3677.0"/> <next x="14368.0" y="3688.0"/> <end x="14406.5" y="3688.0"/> </arc> <arc class="consumption" id="cons_ddb834d5-dd65-42f1-b331-2db453833954" source="wca1_s_wca3_s262_wca1_wca3_sa208" target="pr_c7abb1f4-b911-4ec5-98fb-51a43901919a_p1"> <start x="14368.0" y="3664.0"/> <next x="14368.0" y="3688.0"/> <end x="14406.5" y="3688.0"/> </arc> <arc class="production" id="prod_fb681ee9-2430-4aea-99e4-edaa4c555808" source="pr_c7abb1f4-b911-4ec5-98fb-51a43901919a_p2" target="wca1_s_wca3_s263_wca1_wca3_csa29"> <start x="14436.5" y="3688.0"/> <end x="14471.0" y="3688.0"/> </arc> <arc class="consumption" id="cons_344f8f32-4f59-4e88-9ea6-9b6de49adc08" source="wca1_s_wca3_s266_wca1_wca3_sa211" target="pr_904cdde7-e5ad-4227-be8d-c4252efcfab0_p1"> <start x="14374.0" y="3767.5"/> <end x="14373.0" y="3767.5"/> </arc> <arc class="production" id="prod_06412d82-b0bc-49c7-8efa-be450b7338b3" source="pr_904cdde7-e5ad-4227-be8d-c4252efcfab0_p2" target="wca1_s_wca3_s267_wca1_wca3_sa212"> <start x="14403.0" y="3767.5"/> <end x="14402.0" y="3767.5"/> </arc> <arc class="catalysis" id="modif_e99398fd-4361-4e7c-ad8b-743dd5a31c51" source="wca1_s_wca3_s263_wca1_wca3_csa29" target="pr_904cdde7-e5ad-4227-be8d-c4252efcfab0"> <start x="14471.0" y="3688.0"/> <end x="14388.0" y="3762.5"/> </arc> <arc class="consumption" id="cons_815596f7-9b30-4d0f-ae20-302a20a43eff" source="wca1_s_wca3_s267_wca1_wca3_sa212" target="pr_34c9fce3-f35f-4eec-a1f4-2a8620c32d82_p1"> <start x="14450.75" y="3780.0"/> <end x="14425.375" y="3841.5"/> </arc> <arc class="production" id="prod_817e88e5-b8c3-4528-a09b-43e7b732fbae" source="pr_34c9fce3-f35f-4eec-a1f4-2a8620c32d82_p2" target="wca1_s_wca3_s194_wca1_wca3_sa155"> <start x="14425.375" y="3871.5"/> <end x="14400.0" y="3933.0"/> </arc> <arc class="stimulation" id="direct_701d7116-f05e-4eb4-b454-35a4e45611cc" source="wca1_s_wca3_s271_wca1_wca3_sa215" target="wca1_s_wca3_s270_wca1_wca3_csa30"> <start x="14564.2295" y="3497.0"/> <end x="14678.0" y="3626.0"/> </arc> <arc class="consumption" id="cons_f1ad8b50-d942-4514-a34a-dc23d135e9b8" source="wca1_s_wca3_s272_wca1_wca3_sa216" target="pr_05eceebf-be10-48d1-9fee-19f4e0ae3a89_p1"> <start x="14658.0" y="3820.0"/> <end x="14657.0" y="3820.0"/> </arc> <arc class="production" id="prod_7ec9b7b3-b68c-4dcd-80bb-4eb9abf0ab0c" source="pr_05eceebf-be10-48d1-9fee-19f4e0ae3a89_p2" target="wca1_s_wca3_s273_wca1_wca3_sa217"> <start x="14687.0" y="3820.0"/> <end x="14686.0" y="3820.0"/> </arc> <arc class="catalysis" id="modif_131d719d-c4f4-4a6a-a2ed-abc09d60a02e" source="wca1_s_wca3_s270_wca1_wca3_csa30" target="pr_05eceebf-be10-48d1-9fee-19f4e0ae3a89"> <start x="14678.0" y="3746.0"/> <end x="14672.0" y="3815.0"/> </arc> <arc class="consumption" id="cons_7fc6423c-f143-4473-b7d2-25f9cca5532b" source="wca1_s_wca3_s5_wca1_wca3_sa5" target="pr_f43d2d93-d481-4549-b55f-1c7b66314afa_p1"> <start x="14051.5" y="3677.0"/> <next x="14757.0" y="3739.0"/> <end x="14791.75" y="3787.187"/> </arc> <arc class="consumption" id="cons_871d889b-0558-4166-93c1-e38132691b71" source="wca1_s_wca3_s270_wca1_wca3_csa30" target="pr_f43d2d93-d481-4549-b55f-1c7b66314afa_p1"> <start x="14728.0" y="3686.0"/> <next x="14757.0" y="3739.0"/> <end x="14791.75" y="3787.187"/> </arc> <arc class="production" id="prod_d98af842-53f0-41db-be5e-a888b48c7876" source="pr_f43d2d93-d481-4549-b55f-1c7b66314afa_p2" target="wca1_s_wca3_s281_wca1_wca3_csa31"> <start x="14821.75" y="3787.187"/> <end x="14852.5" y="3831.5"/> </arc> <arc class="inhibition" id="direct_926cc11c-b7b6-46f8-b2d4-b3db6c066c5b" source="wca1_s_wca3_s282_wca1_wca3_sa221" target="wca1_s_wca3_s4_wca1_wca3_sa4"> <start x="13864.213" y="3292.0"/> <end x="13866.75" y="3471.0"/> </arc> <arc class="consumption" id="cons_6f9f60bc-77fc-4105-8599-27524629c6b5" source="wca1_s_wca3_s289_wca1_wca3_sa226" target="pr_ac320066-5ea2-4b3e-aa2f-e8b530a60497_p1"> <start x="12934.0" y="3624.0"/> <next x="12934.5" y="3572.625"/> <end x="12928.976" y="3566.5625"/> </arc> <arc class="consumption" id="cons_da6436c8-7215-4ff1-8ff1-fdf2e153e4ec" source="wca1_s1327_wca1_wca3_csa32" target="pr_ac320066-5ea2-4b3e-aa2f-e8b530a60497_p1"> <start x="12987.0" y="3531.0"/> <next x="12934.5" y="3572.625"/> <end x="12928.976" y="3566.5625"/> </arc> <arc class="production" id="prod_783389dc-6435-4d9d-8a3a-8edbf0f0e331" source="pr_ac320066-5ea2-4b3e-aa2f-e8b530a60497_p2" target="wca1_s_wca3_s788_wca1_wca3_csa33"> <start x="12928.976" y="3536.5625"/> <end x="12924.5" y="3534.5"/> </arc> <arc class="modulation" id="direct_53784f15-880f-4d96-9c0a-7e80f50e13ee" source="wca1_s_wca3_s302_wca1_wca3_sa232" target="wca1_s_wca3_s788_wca1_wca3_csa33"> <start x="13020.385" y="3419.0"/> <end x="12972.0" y="3456.0"/> </arc> <arc class="inhibition" id="direct_924cc324-c354-454b-a2b8-3b3bf0d12a6f" source="wca1_s_wca3_s289_wca1_wca3_sa226" target="wca1_s1327_wca1_wca3_csa32"> <start x="12934.0" y="3624.0"/> <end x="13010.75" y="3558.0"/> </arc> <arc class="consumption" id="cons_73bd344c-0137-40c4-a64c-b3d4b2805270" source="wca1_s_wca3_s289_wca1_wca3_sa226" target="pr_937ca5a6-ce27-4d35-bcae-c385cddc0bea_p1"> <start x="12934.0" y="3664.0"/> <end x="12934.0" y="3698.5"/> </arc> <arc class="production" id="prod_15752f76-5f98-4d52-adf5-fe01152756c8" source="pr_937ca5a6-ce27-4d35-bcae-c385cddc0bea_p2" target="wca1_s_wca3_s304_wca1_wca3_sa233"> <start x="12934.0" y="3728.5"/> <end x="12934.0" y="3763.0"/> </arc> <arc class="catalysis" id="modif_6b5312f8-8835-4342-aa65-684118ac8be1" source="wca1_s1327_wca1_wca3_csa32" target="pr_937ca5a6-ce27-4d35-bcae-c385cddc0bea"> <start x="13034.5" y="3558.0"/> <end x="12939.0" y="3713.5"/> </arc> <arc class="consumption" id="cons_9178e662-f1bf-4184-9f5e-890293a54a51" source="wca1_s_wca3_s332_wca1_wca3_csa39" target="pr_d4b14322-59f2-484b-9087-69a52035bbff_p1"> <start x="13127.0" y="3859.0"/> <end x="13138.0" y="3862.5"/> </arc> <arc class="production" id="prod_7da6f3b8-4ff8-4329-8451-6dd07e92f9bc" source="pr_d4b14322-59f2-484b-9087-69a52035bbff_p2" target="wca1_s_wca3_s339_wca1_wca3_csa41"> <start x="13168.0" y="3862.5"/> <end x="13179.0" y="3866.0"/> </arc> <arc class="catalysis" id="modif_119775f6-9b2d-495d-9bad-99ca30d11f99" source="wca1_s_wca3_s312_wca1_wca3_sa240" target="pr_d4b14322-59f2-484b-9087-69a52035bbff"> <start x="13198.0" y="3764.0"/> <end x="13153.667" y="3857.5447"/> </arc> <arc class="consumption" id="cons_22d41852-9d95-4c86-ad9a-536b3041e49d" source="wca1_s_wca3_s289_wca1_wca3_sa226" target="pr_1bc49d78-a396-46d5-acaf-272dce8a5414_p1"> <start x="12914.0" y="3664.0"/> <end x="12913.875" y="3729.5"/> </arc> <arc class="production" id="prod_48d3e620-8bbe-40e2-b80b-6639af34aeca" source="pr_1bc49d78-a396-46d5-acaf-272dce8a5414_p2" target="wca1_s_wca3_s307_wca1_wca3_sa235"> <start x="12913.875" y="3759.5"/> <end x="12913.75" y="3825.0"/> </arc> <arc class="catalysis" id="modif_949157d1-e247-4a61-ab9e-33f2e4a1c821" source="wca1_s_wca3_s794_wca1_wca3_csa73" target="pr_1bc49d78-a396-46d5-acaf-272dce8a5414"> <start x="12917.25" y="3907.0"/> <end x="12918.867" y="3749.5078"/> </arc> <arc class="inhibition" id="direct_942f56c7-3b1a-4250-be3c-fc669ba9bce8" source="wca1_s_wca3_s311_wca1_wca3_sa257" target="wca1_s_wca3_s309_wca1_wca3_sa237"> <start x="13459.75" y="3667.0"/> <end x="13417.75" y="3710.0"/> </arc> <arc class="stimulation" id="direct_b8497a1b-a79f-4bd4-b4fa-9b73087e05de" source="wca1_s_wca3_s310_wca1_wca3_sa238" target="wca1_s_wca3_s794_wca1_wca3_csa73"> <start x="13083.0" y="4016.0"/> <end x="13002.0" y="3961.5"/> </arc> <arc class="consumption" id="cons_c04f5524-d7f6-44ea-9da9-022c317f5866" source="wca1_s_wca3_s328_wca1_wca3_csa38" target="pr_cb1bf223-0e52-4d5c-9052-b3646ef047b1_p1"> <start x="13123.0" y="3618.0"/> <end x="13157.5" y="3624.0"/> </arc> <arc class="production" id="prod_46013809-81e2-472a-a89a-a834d450aa50" source="pr_cb1bf223-0e52-4d5c-9052-b3646ef047b1_p2" target="wca1_s_wca3_s336_wca1_wca3_csa40"> <start x="13187.5" y="3624.0"/> <end x="13222.0" y="3630.0"/> </arc> <arc class="catalysis" id="modif_a4654cfa-c998-439c-af94-1af3ed4686bc" source="wca1_s_wca3_s312_wca1_wca3_sa240" target="pr_cb1bf223-0e52-4d5c-9052-b3646ef047b1"> <start x="13198.0" y="3724.0"/> <end x="13171.898" y="3628.9636"/> </arc> <arc class="consumption" id="cons_ac087694-c012-49a3-bd0f-e9bb3ea5d884" source="wca1_s_wca3_s311_wca1_wca3_sa257" target="pr_df9f9121-3466-484a-9db9-37da3f212fd2_p1"> <start x="13419.75" y="3647.0"/> <end x="13211.875" y="3650.5"/> </arc> <arc class="production" id="prod_3ef7c104-3ef4-42c3-97cb-606bacf2038c" source="pr_df9f9121-3466-484a-9db9-37da3f212fd2_p2" target="wca1_s_wca3_s289_wca1_wca3_sa226"> <start x="13181.875" y="3650.5"/> <end x="12974.0" y="3654.0"/> </arc> <arc class="catalysis" id="modif_e8cf731a-f6f8-4e16-88e2-f59a2fbdc302" source="wca1_s_wca3_s313_wca1_wca3_sa241" target="pr_df9f9121-3466-484a-9db9-37da3f212fd2"> <start x="13309.0" y="3762.0"/> <end x="13196.953" y="3655.4993"/> </arc> <arc class="consumption" id="cons_49032d59-2fa5-4647-9290-de24853f5486" source="wca1_s_wca3_s305_wca1_wca3_sa234" target="pr_75a7f7e2-e230-42e9-a521-af43eab08718_p1"> <start x="13406.375" y="3846.0"/> <end x="13205.1875" y="3824.5"/> </arc> <arc class="production" id="prod_e2f7e7c9-faf1-46d5-a369-632201ad9f53" source="pr_75a7f7e2-e230-42e9-a521-af43eab08718_p2" target="wca1_s_wca3_s304_wca1_wca3_sa233"> <start x="13175.1875" y="3824.5"/> <end x="12974.0" y="3803.0"/> </arc> <arc class="catalysis" id="modif_40e30d96-d8d9-4ab7-b32d-3b90c924aa97" source="wca1_s_wca3_s313_wca1_wca3_sa241" target="pr_75a7f7e2-e230-42e9-a521-af43eab08718"> <start x="13309.0" y="3762.0"/> <end x="13190.683" y="3819.5247"/> </arc> <arc class="consumption" id="cons_2fa2276c-02cf-4509-8da2-8b89448179ce" source="wca1_s_wca3_s314_wca1_wca3_csa34" target="pr_a119e6c6-8d30-4117-a032-b119d0044c82_p1"> <start x="13230.0" y="4094.0"/> <end x="13126.0" y="4094.0"/> </arc> <arc class="production" id="prod_0057d6a3-2ab2-49bf-9603-778f55f3d6b3" source="pr_a119e6c6-8d30-4117-a032-b119d0044c82_p2" target="wca1_s_wca3_s798_wca1_wca3_csa36"> <start x="13096.0" y="4094.0"/> <end x="12992.0" y="4094.0"/> </arc> <arc class="catalysis" id="modif_54ffaa95-1bee-455b-8584-6b01aa19cd94" source="wca1_s_wca3_s313_wca1_wca3_sa241" target="pr_a119e6c6-8d30-4117-a032-b119d0044c82"> <start x="13349.0" y="3782.0"/> <end x="13111.0" y="4089.0"/> </arc> <arc class="consumption" id="cons_77623478-3c07-4170-a1cf-a5602597f49e" source="wca1_s_wca3_s317_wca1_wca3_csa35" target="pr_f5df4524-7003-430b-8a3a-8a1dafe8c0ef_p1"> <start x="13250.0" y="4230.0"/> <end x="13136.0" y="4230.0"/> </arc> <arc class="production" id="prod_0550dbe0-7b3e-4ccb-9a60-ad21ed0909c5" source="pr_f5df4524-7003-430b-8a3a-8a1dafe8c0ef_p2" target="wca1_s_wca3_s323_wca1_wca3_csa37"> <start x="13106.0" y="4230.0"/> <end x="12992.0" y="4230.0"/> </arc> <arc class="catalysis" id="modif_0b146d20-4e10-410d-866c-568dc1f2c666" source="wca1_s_wca3_s313_wca1_wca3_sa241" target="pr_f5df4524-7003-430b-8a3a-8a1dafe8c0ef"> <start x="13349.0" y="3782.0"/> <end x="13121.0" y="4225.0"/> </arc> <arc class="consumption" id="cons_8eca8739-331f-445c-a9ad-37027a2d185c" source="wca1_s_wca3_s5_wca1_wca3_sa5" target="pr_b735c1ed-cf6c-49bb-8378-918f3ea3f46d_p1"> <start x="14011.5" y="3697.0"/> <next x="13445.75" y="3958.3264"/> <end x="13375.875" y="3997.0762"/> </arc> <arc class="consumption" id="cons_9fc16e8c-fcf7-4a5b-bf15-4990cc61c0cf" source="wca1_s_wca3_s305_wca1_wca3_sa234" target="pr_b735c1ed-cf6c-49bb-8378-918f3ea3f46d_p1"> <start x="13446.375" y="3876.0"/> <next x="13445.75" y="3958.3264"/> <end x="13375.875" y="3997.0762"/> </arc> <arc class="production" id="prod_537e708e-64b6-498d-89d7-a376e97039ce" source="pr_b735c1ed-cf6c-49bb-8378-918f3ea3f46d_p2" target="wca1_s_wca3_s314_wca1_wca3_csa34"> <start x="13345.875" y="3997.0762"/> <end x="13280.0" y="4034.0"/> </arc> <arc class="consumption" id="cons_2c21a783-dae0-4fda-a32f-6b6b94a2fc27" source="wca1_s_wca3_s5_wca1_wca3_sa5" target="pr_9cd3a5b4-46d7-49ce-a907-3bda15436484_p1"> <start x="14011.5" y="3697.0"/> <next x="13366.0" y="4119.7856"/> <end x="13357.709" y="4161.8926"/> </arc> <arc class="consumption" id="cons_5f60a0be-7e56-4938-b930-4d7643427d45" source="wca1_s_wca3_s311_wca1_wca3_sa257" target="pr_9cd3a5b4-46d7-49ce-a907-3bda15436484_p1"> <start x="13459.75" y="3667.0"/> <next x="13366.0" y="4119.7856"/> <end x="13357.709" y="4161.8926"/> </arc> <arc class="production" id="prod_0aeb38c0-65fd-4bbf-8b0f-512de15e93e7" source="pr_9cd3a5b4-46d7-49ce-a907-3bda15436484_p2" target="wca1_s_wca3_s317_wca1_wca3_csa35"> <start x="13357.709" y="4191.8926"/> <end x="13350.0" y="4230.0"/> </arc> <arc class="consumption" id="cons_45c9aab7-c265-4a7d-8883-c5ec800c34ea" source="wca1_s_wca3_s289_wca1_wca3_sa226" target="pr_df320ebc-7b11-4836-8174-f76592d37cd1_p1"> <start x="12974.0" y="3644.0"/> <next x="12991.0" y="3684.1633"/> <end x="13008.77" y="3679.0815"/> </arc> <arc class="consumption" id="cons_08694c82-b110-470f-862e-36a186af08cb" source="wca1_s_wca3_s326_wca1_wca3_sa250" target="pr_df320ebc-7b11-4836-8174-f76592d37cd1_p1"> <start x="12971.0" y="3709.0"/> <next x="12991.0" y="3684.1633"/> <end x="13008.77" y="3679.0815"/> </arc> <arc class="production" id="prod_5f57c1a6-8c90-4547-83b9-5e66de502e0f" source="pr_df320ebc-7b11-4836-8174-f76592d37cd1_p2" target="wca1_s_wca3_s328_wca1_wca3_csa38"> <start x="13008.77" y="3649.0815"/> <end x="13023.0" y="3648.0"/> </arc> <arc class="consumption" id="cons_d10448c8-547f-4228-9643-c36c808047a5" source="wca1_s_wca3_s304_wca1_wca3_sa233" target="pr_92bb8103-f736-4c5a-b6e4-747c081e87b0_p1"> <start x="12974.0" y="3783.0"/> <next x="12990.0" y="3778.0"/> <end x="13009.951" y="3790.5"/> </arc> <arc class="consumption" id="cons_2607e8cf-0ea8-4364-ae2a-b7f7b0e35f3e" source="wca1_s_wca3_s326_wca1_wca3_sa250" target="pr_92bb8103-f736-4c5a-b6e4-747c081e87b0_p1"> <start x="12971.0" y="3749.0"/> <next x="12990.0" y="3778.0"/> <end x="13009.951" y="3790.5"/> </arc> <arc class="production" id="prod_f2e114f4-5d23-4b2a-a6d4-49f62c6a8021" source="pr_92bb8103-f736-4c5a-b6e4-747c081e87b0_p2" target="wca1_s_wca3_s332_wca1_wca3_csa39"> <start x="13009.951" y="3820.5"/> <end x="13027.0" y="3829.0"/> </arc> <arc class="consumption" id="cons_fcb31497-c34f-42f4-9515-fe4623497756" source="wca1_s_wca3_s339_wca1_wca3_csa41" target="pr_834b562a-3e00-4179-99a5-41e7b5c4a71d_p1"> <start x="13279.0" y="3836.0"/> <end x="13313.6875" y="3836.0"/> </arc> <arc class="production" id="prod_73e908a6-25cd-4223-84cc-c6a694f6bb34" source="pr_834b562a-3e00-4179-99a5-41e7b5c4a71d_p2" target="wca1_s_wca3_s335_wca1_wca3_sa258"> <start x="13343.6875" y="3836.0"/> <next x="13378.375" y="3836.0"/> <end x="13421.0" y="3792.0"/> </arc> <arc class="production" id="prod_567f551b-c5d1-465b-954e-aa4e18811699" source="pr_834b562a-3e00-4179-99a5-41e7b5c4a71d_p2" target="wca1_s_wca3_s305_wca1_wca3_sa234"> <start x="13343.6875" y="3836.0"/> <next x="13378.375" y="3836.0"/> <end x="13406.375" y="3856.0"/> </arc> <arc class="consumption" id="cons_a98369fd-de8c-4d55-8588-8c522dcf6478" source="wca1_s_wca3_s336_wca1_wca3_csa40" target="pr_3f96525c-a5e5-46b3-bb15-5e4758768a76_p1"> <start x="13322.0" y="3660.0"/> <end x="13341.875" y="3660.0"/> </arc> <arc class="production" id="prod_50fedc22-66c3-4cdd-b336-faaac6bd967f" source="pr_3f96525c-a5e5-46b3-bb15-5e4758768a76_p2" target="wca1_s_wca3_s311_wca1_wca3_sa257"> <start x="13371.875" y="3660.0"/> <next x="13391.75" y="3660.0"/> <end x="13419.75" y="3647.0"/> </arc> <arc class="production" id="prod_65ede434-7c07-4b4c-b4de-e8f3ecf81937" source="pr_3f96525c-a5e5-46b3-bb15-5e4758768a76_p2" target="wca1_s_wca3_s335_wca1_wca3_sa258"> <start x="13371.875" y="3660.0"/> <next x="13391.75" y="3660.0"/> <end x="13421.0" y="3792.0"/> </arc> <arc class="inhibition" id="direct_7c3bbd7e-bff0-4471-b7b6-601a8d3838d8" source="wca1_s_wca3_s311_wca1_wca3_sa257" target="wca1_s_wca3_s342_wca1_wca3_sa261"> <start x="13499.75" y="3647.0"/> <end x="13533.0" y="3647.0"/> </arc> <arc class="consumption" id="cons_fdd288af-2fc5-4024-bd2d-d01b6e331570" source="wca1_s1327_wca1_wca3_csa42" target="pr_bd0178a7-693e-43db-92a8-70702c81fa4b_p1"> <start x="13137.0" y="3503.0"/> <end x="13124.5" y="3503.5"/> </arc> <arc class="production" id="prod_b294bd8f-7fa2-4f6d-9556-0f1495c45d50" source="pr_bd0178a7-693e-43db-92a8-70702c81fa4b_p2" target="wca1_s1327_wca1_wca3_csa32"> <start x="13094.5" y="3503.5"/> <end x="13082.0" y="3504.0"/> </arc> <arc class="stimulation" id="modif_da3d2c94-9c95-4b08-b514-ca3720a5abbf" source="wca1_s_wca3_s347_wca1_wca3_sa266" target="pr_bd0178a7-693e-43db-92a8-70702c81fa4b"> <start x="13125.0" y="3428.0"/> <end x="13109.409" y="3498.5007"/> </arc> <arc class="consumption" id="cons_32130825-00be-404f-afb8-6ecfb7dbe55f" source="wca1_s_wca3_s153_wca1_wca3_sa135" target="pr_51fff31f-7096-43d5-b81f-e810713c1022_p1"> <start x="13576.0" y="3375.5"/> <end x="13573.984" y="3359.25"/> </arc> <arc class="production" id="prod_6acefedf-e655-4cc2-9476-d41810cddf0d" source="pr_51fff31f-7096-43d5-b81f-e810713c1022_p2" target="wca1_s_wca3_s348_wca1_wca3_sa267"> <start x="13573.984" y="3329.25"/> <end x="13571.968" y="3313.0"/> </arc> <arc class="consumption" id="cons_fb96919f-b4ec-4f2a-ba0a-231e206f8bfe" source="wca1_s_wca3_s176_wca1_wca3_csa19" target="pr_31f07733-dffe-47a1-81b0-52a86003075f_p1"> <start x="13292.0" y="3537.5"/> <end x="13482.0" y="3676.5"/> </arc> <arc class="production" id="prod_1189c5f7-a10e-4bd1-8c30-d771eaabf6b8" source="pr_31f07733-dffe-47a1-81b0-52a86003075f_p2" target="wca1_s_wca3_s180_wca1_wca3_csa20"> <start x="13512.0" y="3676.5"/> <end x="13702.0" y="3815.5"/> </arc> <arc class="consumption" id="cons_bb881b19-8855-4105-9ecb-612922355e3e" source="wca1_s_wca3_s798_wca1_wca3_csa36" target="pr_76c1058d-a6bf-4293-bed0-df2e5c4e8591_p1"> <start x="12992.0" y="4124.0"/> <end x="13003.5" y="4131.9785"/> </arc> <arc class="production" id="prod_b02ca766-2ba9-4ea0-a05d-e5a6f7123617" source="pr_76c1058d-a6bf-4293-bed0-df2e5c4e8591_p2" target="wca1_s_wca3_s349_wca1_wca3_sa268"> <start x="13033.5" y="4131.9785"/> <end x="13045.0" y="4139.957"/> </arc> <arc class="consumption" id="cons_0280998a-d98a-4d25-a313-85d99e3c01df" source="wca1_s_wca3_s323_wca1_wca3_csa37" target="pr_83bf662e-931a-4795-9c8a-177d84ed00a0_p1"> <start x="12992.0" y="4200.0"/> <end x="13008.969" y="4183.5"/> </arc> <arc class="production" id="prod_eb7c13bc-5479-4f3f-ad83-6b8b2e8ae78c" source="pr_83bf662e-931a-4795-9c8a-177d84ed00a0_p2" target="wca1_s_wca3_s349_wca1_wca3_sa268"> <start x="13038.969" y="4183.5"/> <end x="13055.9375" y="4167.0"/> </arc> <arc class="inhibition" id="direct_db2d9d36-e1e0-4c73-97a1-b6229310808a" source="wca1_s_wca3_s347_wca1_wca3_sa266" target="wca1_s_wca3_s794_wca1_wca3_csa73"> <start x="13125.0" y="3428.0"/> <end x="12973.75" y="3907.0"/> </arc> <arc class="consumption" id="cons_be04c964-6d6a-4501-8e53-120b67469a7d" source="wca1_s_wca3_s160_wca1_wca3_sa152" target="pr_4dd47f3d-6906-44f8-80fc-d8a610e5d3c1_p1"> <start x="14058.417" y="4141.5"/> <end x="14058.084" y="4117.75"/> </arc> <arc class="production" id="prod_e7ac27bc-9730-4c6e-85ee-fff8b0f06415" source="pr_4dd47f3d-6906-44f8-80fc-d8a610e5d3c1_p2" target="wca1_s_wca3_s362_wca1_wca3_sa276"> <start x="14058.084" y="4087.75"/> <end x="14057.75" y="4064.0"/> </arc> <arc class="catalysis" id="modif_22dd4585-1b28-469c-b16c-0508dfa9d7a6" source="wca1_s_wca3_s363_wca1_wca3_sa277" target="pr_4dd47f3d-6906-44f8-80fc-d8a610e5d3c1"> <start x="14117.0" y="4095.0"/> <end x="14063.084" y="4102.707"/> </arc> <arc class="consumption" id="cons_325165c1-9729-40b6-8631-7f38283ca1f2" source="wca1_s_wca3_s311_wca1_wca3_sa257" target="pr_1fbc37b4-b071-4f2f-adb5-6df17ec588e2_p1"> <start x="13459.75" y="3667.0"/> <next x="13510.0" y="4327.0"/> <end x="13566.5" y="4338.831"/> </arc> <arc class="consumption" id="cons_3e82c561-114c-43c6-8017-e29a70582ce7" source="wca1_s_wca3_s368_wca1_wca3_sa281" target="pr_1fbc37b4-b071-4f2f-adb5-6df17ec588e2_p1"> <start x="13368.0" y="4333.0"/> <next x="13510.0" y="4327.0"/> <end x="13566.5" y="4338.831"/> </arc> <arc class="production" id="prod_58154ac5-698c-4811-ab7f-25f7200fd60d" source="pr_1fbc37b4-b071-4f2f-adb5-6df17ec588e2_p2" target="wca1_s_wca3_s365_wca1_wca3_csa44"> <start x="13596.5" y="4338.831"/> <end x="13649.0" y="4350.0"/> </arc> <arc class="consumption" id="cons_ed2a6409-e3d9-49c5-9edf-e53761e3a91d" source="wca1_s_wca3_s364_wca1_wca3_sa278" target="pr_78c53d24-2f9d-433e-86aa-667372824fd8_p1"> <start x="13239.0" y="4330.0"/> <end x="13245.5" y="4331.5"/> </arc> <arc class="production" id="prod_7bbf3f05-208b-49a4-ab07-55e156921fb4" source="pr_78c53d24-2f9d-433e-86aa-667372824fd8_p2" target="wca1_s_wca3_s368_wca1_wca3_sa281"> <start x="13275.5" y="4331.5"/> <end x="13282.0" y="4333.0"/> </arc> <arc class="catalysis" id="modif_7961200d-a36d-41de-9ab8-d61550bc606c" source="wca1_s_wca3_s369_wca1_wca3_sa282" target="pr_78c53d24-2f9d-433e-86aa-667372824fd8"> <start x="13260.0" y="4395.0"/> <end x="13260.152" y="4336.488"/> </arc> <arc class="consumption" id="cons_2a3eac09-e78c-442c-a750-ebec37db9979" source="wca1_s_wca3_s191_wca1_wca3_sa151" target="pr_f4c90392-98ba-4f38-8694-9c2695ff940c_p1"> <start x="14151.406" y="4181.5"/> <next x="13769.406" y="4337.0"/> <end x="13774.203" y="4336.166"/> </arc> <arc class="consumption" id="cons_0748eace-2dab-4296-bf0b-6fdc870ae37c" source="wca1_s_wca3_s365_wca1_wca3_csa44" target="pr_f4c90392-98ba-4f38-8694-9c2695ff940c_p1"> <start x="13749.0" y="4350.0"/> <next x="13769.406" y="4337.0"/> <end x="13774.203" y="4336.166"/> </arc> <arc class="production" id="prod_d81903ea-43ff-41b7-a831-afcfa1086a4c" source="pr_f4c90392-98ba-4f38-8694-9c2695ff940c_p2" target="wca1_s_wca3_s379_wca1_wca3_csa45"> <start x="13804.203" y="4336.166"/> <end x="13805.0" y="4335.5"/> </arc> <arc class="consumption" id="cons_535c94f8-aebc-4fab-a2de-bde48406066c" source="wca1_s_wca3_s379_wca1_wca3_csa45" target="pr_913b9e2e-84fc-4d1f-9c7a-b8d1466ff73f_p1"> <start x="13854.0" y="4416.0"/> <end x="13855.75" y="4430.0"/> </arc> <arc class="production" id="prod_1bc1a917-7f55-4343-a06c-ad4adc2d692c" source="pr_913b9e2e-84fc-4d1f-9c7a-b8d1466ff73f_p2" target="wca1_s_wca3_s380_wca1_wca3_csa46"> <start x="13855.75" y="4460.0"/> <end x="13857.5" y="4474.0"/> </arc> <arc class="catalysis" id="modif_66461eed-2d84-40f3-93d6-ce9c098ace53" source="wca1_s_wca3_s363_wca1_wca3_sa277" target="pr_913b9e2e-84fc-4d1f-9c7a-b8d1466ff73f"> <start x="14157.0" y="4115.0"/> <end x="13860.741" y="4444.6987"/> </arc> <arc class="consumption" id="cons_0d600e54-8305-46f1-98f2-b5981787e361" source="wca1_s_wca3_s380_wca1_wca3_csa46" target="pr_9a804ea5-9c18-497a-a056-acd9f1da92db_p1"> <start x="13857.5" y="4635.0"/> <next x="13732.5" y="4647.0"/> <end x="13726.375" y="4655.008"/> </arc> <arc class="consumption" id="cons_89f7e2b7-e420-495c-8fef-46fd0aad3341" source="wca1_s_wca3_s705_wca1_wca3_csa3" target="pr_9a804ea5-9c18-497a-a056-acd9f1da92db_p1"> <start x="13946.5" y="4500.125"/> <next x="13732.5" y="4647.0"/> <end x="13726.375" y="4655.008"/> </arc> <arc class="production" id="prod_a45912e4-0e54-40ca-88ec-2c583a084e6d" source="pr_9a804ea5-9c18-497a-a056-acd9f1da92db_p2" target="wca1_s_wca3_s708_wca1_wca3_csa49"> <start x="13696.375" y="4655.008"/> <end x="13694.25" y="4661.5"/> </arc> <arc class="consumption" id="cons_764effe1-347b-42b0-a060-a5514c85b8ca" source="wca1_s_wca3_s708_wca1_wca3_csa49" target="pr_9c7fc6e1-f486-4ad8-90c4-d7f6f3db82e7_p1"> <start x="13755.25" y="4924.5"/> <end x="13754.875" y="4923.4004"/> </arc> <arc class="production" id="prod_0f004241-727a-4355-a8b9-f8887e06f9f6" source="pr_9c7fc6e1-f486-4ad8-90c4-d7f6f3db82e7_p2" target="wca1_s_wca3_s404_wca1_wca3_csa50"> <start x="13784.875" y="4923.4004"/> <next x="13784.5" y="4922.301"/> <end x="13817.0" y="4734.0"/> </arc> <arc class="production" id="prod_43235647-ecc0-44d6-b094-5339fbe71387" source="pr_9c7fc6e1-f486-4ad8-90c4-d7f6f3db82e7_p2" target="wca1_s_wca3_s405_wca1_wca3_csa51"> <start x="13784.875" y="4923.4004"/> <next x="13784.5" y="4922.301"/> <end x="13826.0" y="4878.0"/> </arc> <arc class="production" id="addprod_b6f9b2c4-9c61-4a06-a819-51a2de02bd8e" source="pr_9c7fc6e1-f486-4ad8-90c4-d7f6f3db82e7_p2" target="wca1_s_wca3_s413_wca1_wca3_csa52"> <start x="13784.875" y="4923.4004"/> <end x="13804.0" y="5070.5"/> </arc> <arc class="production" id="addprod_f6b27327-12de-4f07-9e60-395a9c571c0e" source="pr_9c7fc6e1-f486-4ad8-90c4-d7f6f3db82e7_p2" target="wca1_s_wca3_s677_wca1_wca3_csa70"> <start x="13784.875" y="4923.4004"/> <end x="14613.0" y="4496.0"/> </arc> <arc class="consumption" id="cons_870be573-d7dd-4d66-9c68-b10631b6fd71" source="wca1_s_wca3_s404_wca1_wca3_csa50" target="pr_f1effaa2-6aca-4542-a18f-349ec9ce5869_p1"> <start x="13817.0" y="4704.0"/> <end x="13418.0" y="4586.5"/> </arc> <arc class="production" id="prod_b0fc68c6-3131-4f20-a91d-12cd71f104c3" source="pr_f1effaa2-6aca-4542-a18f-349ec9ce5869_p2" target="wca1_s_wca3_s414_wca1_wca3_csa53"> <start x="13388.0" y="4586.5"/> <end x="12989.0" y="4469.0"/> </arc> <arc class="consumption" id="cons_6125f1f5-150e-42d3-83ad-b90038358a7e" source="wca1_s_wca3_s413_wca1_wca3_csa52" target="pr_3068d477-891d-46c5-9ec9-f6a16aa4a8eb_p1"> <start x="13907.0" y="5070.5"/> <end x="13936.568" y="5022.0"/> </arc> <arc class="production" id="prod_d35c53c7-6978-438b-9f00-97447ca73eb0" source="pr_3068d477-891d-46c5-9ec9-f6a16aa4a8eb_p2" target="wca1_s_wca3_s364_wca1_wca3_sa278"> <start x="13936.568" y="4992.0"/> <next x="13966.138" y="4943.5"/> <end x="13199.0" y="4350.0"/> </arc> <arc class="production" id="prod_7cc70dde-ece0-4522-8923-c03857a57862" source="pr_3068d477-891d-46c5-9ec9-f6a16aa4a8eb_p2" target="wca1_s_wca3_s804_wca1_wca3_csa22"> <start x="13936.568" y="4992.0"/> <next x="13966.138" y="4943.5"/> <end x="14441.75" y="4448.5"/> </arc> <arc class="consumption" id="addreact_bbf5e84a-97d3-4269-98e5-b939a8d1033f" source="wca1_s_wca3_s190_wca1_wca3_sa150" target="pr_3068d477-891d-46c5-9ec9-f6a16aa4a8eb_p1"> <start x="14243.417" y="4181.5"/> <end x="13936.568" y="5022.0"/> </arc> <arc class="consumption" id="cons_99f30374-2440-4b13-b86a-aaec33007077" source="wca1_s_wca3_s414_wca1_wca3_csa53" target="pr_a13a43d5-5dcb-4d80-bdf8-1b2f2d592e7a_p1"> <start x="12989.0" y="4337.0"/> <end x="13033.107" y="4267.0"/> </arc> <arc class="production" id="prod_0c7f07f7-ea89-4f7e-a7cd-51a7e1106425" source="pr_a13a43d5-5dcb-4d80-bdf8-1b2f2d592e7a_p2" target="wca1_s_wca3_s349_wca1_wca3_sa268"> <start x="13033.107" y="4237.0"/> <end x="13077.216" y="4167.0"/> </arc> <arc class="consumption" id="cons_6354b91b-ebd5-4bb9-a134-6b448a12fd44" source="wca1_s_wca3_s421_wca1_wca3_sa324" target="pr_a84100c2-3167-4b72-8fe1-b76d3d66f152_p1"> <start x="13473.0" y="5197.0"/> <end x="13483.0" y="5196.6"/> </arc> <arc class="production" id="prod_487555bb-14b6-44a2-bf3f-c98e0a99e855" source="pr_a84100c2-3167-4b72-8fe1-b76d3d66f152_p2" target="wca1_s_wca3_s422_wca1_wca3_sa325"> <start x="13513.0" y="5196.6"/> <end x="13523.0" y="5196.2"/> </arc> <arc class="inhibition" id="modif_0e32c90f-3600-4a8a-b495-3fa5d74c630f" source="wca1_s_wca3_s461_wca1_wca3_csa57" target="pr_a84100c2-3167-4b72-8fe1-b76d3d66f152"> <start x="13214.5" y="4753.0"/> <end x="13497.92" y="5191.6006"/> </arc> <arc class="consumption" id="cons_50ebad05-ac82-40ee-a601-e98f0dde141d" source="wca1_s_wca3_s427_wca1_wca3_sa326" target="pr_8c33808d-d659-4b7f-8c6e-baaafd39fdbc_p1"> <start x="13430.0" y="3947.0"/> <next x="13503.714" y="3976.0"/> <end x="13477.482" y="4005.1646"/> </arc> <arc class="consumption" id="cons_57de53fc-78eb-4af9-8378-8f633f0b19b7" source="wca1_s_wca3_s15_wca1_wca3_csa8" target="pr_8c33808d-d659-4b7f-8c6e-baaafd39fdbc_p1"> <start x="14209.429" y="3897.5"/> <next x="13503.714" y="3976.0"/> <end x="13477.482" y="4005.1646"/> </arc> <arc class="production" id="prod_e40db303-eb6a-45c0-bac2-503042531e9c" source="pr_8c33808d-d659-4b7f-8c6e-baaafd39fdbc_p2" target="wca1_s_wca3_s435_wca1_wca3_csa54"> <start x="13447.482" y="4005.1646"/> <end x="13425.25" y="4031.5"/> </arc> <arc class="inhibition" id="modif_6b6ef222-1334-49fa-80d1-742c6aab98f7" source="wca1_s_wca3_s454_wca1_wca3_csa56" target="pr_8c33808d-d659-4b7f-8c6e-baaafd39fdbc"> <start x="13262.0" y="4515.0"/> <end x="13465.37" y="4009.2466"/> </arc> <arc class="consumption" id="addreact_04f594ae-1133-4cf8-92e8-b463bff9fd82" source="wca1_s_wca3_s81_wca1_wca3_sa71" target="pr_8c33808d-d659-4b7f-8c6e-baaafd39fdbc_p1"> <start x="13492.8125" y="3729.0"/> <end x="13477.482" y="4005.1646"/> </arc> <arc class="consumption" id="cons_180c46a0-219c-4bf9-9e1d-315b76451750" source="wca1_s_wca3_s435_wca1_wca3_csa54" target="pr_687b570f-49fc-45a5-8caa-0e79c7820123_p1"> <start x="13425.25" y="4298.5"/> <end x="13425.9375" y="4323.5"/> </arc> <arc class="production" id="prod_dfb8f6bc-098f-4965-b298-41be44a0e1dc" source="pr_687b570f-49fc-45a5-8caa-0e79c7820123_p2" target="wca1_s_wca3_s442_wca1_wca3_csa55"> <start x="13425.9375" y="4353.5"/> <end x="13426.625" y="4378.5"/> </arc> <arc class="consumption" id="cons_6b74c879-55ab-458e-8229-8993c1dde468" source="wca1_s_wca3_s448_wca1_wca3_sa337" target="pr_2c27c462-21ef-4762-9e6d-bba756a83ecd_p1"> <start x="14815.0" y="4449.5"/> <end x="14830.5" y="4449.5"/> </arc> <arc class="production" id="prod_1612e54c-84b3-4800-b856-36924277d525" source="pr_2c27c462-21ef-4762-9e6d-bba756a83ecd_p2" target="wca1_s_wca3_s449_wca1_wca3_sa338"> <start x="14860.5" y="4449.5"/> <end x="14876.0" y="4449.5"/> </arc> <arc class="catalysis" id="modif_509c3070-d85b-4a8a-af45-8f1fd9d56865" source="wca1_s_wca3_s476_wca1_wca3_csa58" target="pr_2c27c462-21ef-4762-9e6d-bba756a83ecd"> <start x="13749.8125" y="4533.0"/> <end x="14840.5" y="4454.5"/> </arc> <arc class="catalysis" id="modif_920fe4a1-0be6-45cc-a97f-1b3907132566" source="wca1_s_wca3_s800_wca1_wca3_csa7" target="pr_2c27c462-21ef-4762-9e6d-bba756a83ecd"> <start x="14451.5" y="4943.0"/> <end x="14850.5" y="4454.5"/> </arc> <arc class="inhibition" id="modif_bb60e50b-bfce-4ab0-b99c-cc5f9cb5ce6b" source="wca1_s_wca3_s799_wca1_wca3_csa60" target="pr_2c27c462-21ef-4762-9e6d-bba756a83ecd"> <start x="14273.0" y="4968.0"/> <end x="14845.5" y="4454.5"/> </arc> <arc class="inhibition" id="modif_48ed1dd9-2c40-43f0-a801-3d6929a2ddc4" source="wca1_s_wca3_s571_wca1_wca3_csa65" target="pr_2c27c462-21ef-4762-9e6d-bba756a83ecd"> <start x="13377.0" y="3995.5"/> <end x="14840.5" y="4444.5"/> </arc> <arc class="consumption" id="cons_1aba5abb-3bc5-4412-b56b-6d5e1974b232" source="wca1_s_wca3_s450_wca1_wca3_sa339" target="pr_60ca46c4-c95d-4600-8017-e91cddfb7b93_p1"> <start x="14815.0" y="4490.0"/> <end x="14830.5" y="4490.0"/> </arc> <arc class="production" id="prod_600bae53-f943-4aee-9df9-74f57ca71f7b" source="pr_60ca46c4-c95d-4600-8017-e91cddfb7b93_p2" target="wca1_s_wca3_s451_wca1_wca3_sa340"> <start x="14860.5" y="4490.0"/> <end x="14876.0" y="4490.0"/> </arc> <arc class="catalysis" id="modif_11e5e111-44d4-4855-b3ab-9cae567dd272" source="wca1_s_wca3_s476_wca1_wca3_csa58" target="pr_60ca46c4-c95d-4600-8017-e91cddfb7b93"> <start x="13749.8125" y="4533.0"/> <end x="14840.5" y="4495.0"/> </arc> <arc class="consumption" id="cons_d0aecacf-55a1-4b5b-89c3-721caa898e6b" source="wca1_s_wca3_s427_wca1_wca3_sa326" target="pr_d9c7123f-3c1c-491d-927f-6a0b2847cba3_p1"> <start x="13430.0" y="3947.0"/> <next x="13271.5" y="4367.3125"/> <end x="13242.162" y="4396.1562"/> </arc> <arc class="consumption" id="cons_6e651fbd-0c33-42b9-a219-020cb40bb210" source="wca1_s_wca3_s364_wca1_wca3_sa278" target="pr_d9c7123f-3c1c-491d-927f-6a0b2847cba3_p1"> <start x="13199.0" y="4350.0"/> <next x="13271.5" y="4367.3125"/> <end x="13242.162" y="4396.1562"/> </arc> <arc class="production" id="prod_efb1920b-b9f5-49e4-bdc5-4cee3d946eec" source="pr_d9c7123f-3c1c-491d-927f-6a0b2847cba3_p2" target="wca1_s_wca3_s454_wca1_wca3_csa56"> <start x="13242.162" y="4426.1562"/> <end x="13215.5" y="4451.0"/> </arc> <arc class="consumption" id="cons_9114c4c1-0ca5-427e-83ce-fddef6b8c31e" source="wca1_s_wca3_s454_wca1_wca3_csa56" target="pr_d8733126-47b2-4a86-b85d-662158b0900b_p1"> <start x="13215.5" y="4579.0"/> <end x="13215.0" y="4587.0"/> </arc> <arc class="production" id="prod_7e8a59be-d653-45c8-b199-b55b558faf6d" source="pr_d8733126-47b2-4a86-b85d-662158b0900b_p2" target="wca1_s_wca3_s461_wca1_wca3_csa57"> <start x="13215.0" y="4617.0"/> <end x="13214.5" y="4625.0"/> </arc> <arc class="catalysis" id="modif_a679d592-c3ac-4458-9c07-68da6c0b9cdd" source="wca1_s_wca3_s457_wca1_wca3_sa345" target="pr_d8733126-47b2-4a86-b85d-662158b0900b"> <start x="13266.0" y="4602.0"/> <end x="13219.999" y="4602.109"/> </arc> <arc class="consumption" id="cons_ac6946b0-ac93-406e-8da1-660f454c971f" source="wca1_s_wca3_s422_wca1_wca3_sa325" target="pr_2056537c-8401-40b9-a716-0fdcd5cd7915_p1"> <start x="13603.946" y="5183.5"/> <end x="13795.08" y="4505.25"/> </arc> <arc class="production" id="prod_7f7fc29b-55c8-4f48-849f-eaede9bc8d30" source="pr_2056537c-8401-40b9-a716-0fdcd5cd7915_p2" target="wca1_s_wca3_s104_wca1_wca3_sa94"> <start x="13795.08" y="4475.25"/> <end x="13986.214" y="3797.0"/> </arc> <arc class="consumption" id="cons_e0752f45-0ac3-46d8-a630-3f217c8971ad" source="wca1_s_wca3_s464_wca1_wca3_sa346" target="pr_493d3b7d-0f15-426d-9b45-eb3db1e35fd8_p1"> <start x="13473.0" y="5238.0"/> <end x="13483.0" y="5237.6"/> </arc> <arc class="production" id="prod_b8bd41f2-bd1a-420f-9371-be7f1c35f46c" source="pr_493d3b7d-0f15-426d-9b45-eb3db1e35fd8_p2" target="wca1_s_wca3_s465_wca1_wca3_sa347"> <start x="13513.0" y="5237.6"/> <end x="13523.0" y="5237.2"/> </arc> <arc class="inhibition" id="modif_fa112b10-4286-432a-9ebf-863b1ce36a83" source="wca1_s_wca3_s461_wca1_wca3_csa57" target="pr_493d3b7d-0f15-426d-9b45-eb3db1e35fd8"> <start x="13214.5" y="4753.0"/> <end x="13497.92" y="5232.6006"/> </arc> <arc class="consumption" id="cons_dd6de0f3-e4f6-4d54-a762-3e3253fc5dae" source="wca1_s_wca3_s466_wca1_wca3_sa348" target="pr_8dd00720-9dbb-4d44-a644-12e41d45bfb4_p1"> <start x="14816.0" y="4529.0"/> <end x="14831.0" y="4529.0"/> </arc> <arc class="production" id="prod_0b7fb108-f342-4ff5-a266-b19d26b5bec5" source="pr_8dd00720-9dbb-4d44-a644-12e41d45bfb4_p2" target="wca1_s_wca3_s467_wca1_wca3_sa349"> <start x="14861.0" y="4529.0"/> <end x="14876.0" y="4529.0"/> </arc> <arc class="catalysis" id="modif_bf8da485-4741-4e0b-b491-22eb350f19ea" source="wca1_s_wca3_s476_wca1_wca3_csa58" target="pr_8dd00720-9dbb-4d44-a644-12e41d45bfb4"> <start x="13749.8125" y="4533.0"/> <end x="14841.0" y="4534.0"/> </arc> <arc class="consumption" id="cons_7f145e81-b0a7-4450-8531-7edb87c0d739" source="wca1_s_wca3_s442_wca1_wca3_csa55" target="pr_a086f036-39c3-4a17-8dac-6974aac2f7a7_p1"> <start x="13480.625" y="4512.0"/> <next x="13497.0" y="4516.5"/> <end x="13512.906" y="4525.321"/> </arc> <arc class="consumption" id="cons_0fa11996-1031-45b3-9096-dd8919d93752" source="wca1_s_wca3_s805_wca1_wca3_csa1" target="pr_a086f036-39c3-4a17-8dac-6974aac2f7a7_p1"> <start x="14223.4375" y="4419.625"/> <next x="13497.0" y="4516.5"/> <end x="13512.906" y="4525.321"/> </arc> <arc class="production" id="prod_dffc3367-310a-4ba2-8d7e-27ace4b16cce" source="pr_a086f036-39c3-4a17-8dac-6974aac2f7a7_p2" target="wca1_s_wca3_s476_wca1_wca3_csa58"> <start x="13542.906" y="4525.321"/> <end x="13554.8125" y="4533.0"/> </arc> <arc class="production" id="addprod_75dbbe55-ac3e-4099-b96a-9cb4f3d955be" source="pr_a086f036-39c3-4a17-8dac-6974aac2f7a7_p2" target="wca1_s_wca3_s29_wca1_wca3_csa4"> <start x="13542.906" y="4525.321"/> <end x="13967.4375" y="4883.0"/> </arc> <arc class="consumption" id="cons_d94277d0-22c1-40dc-b7d7-2c3e2910d498" source="wca1_s_wca3_s31_wca1_wca3_sa26" target="pr_fbb2d30a-fe29-47bd-ab7c-2d810e2f0adf_p1"> <start x="14427.0" y="4568.117"/> <end x="14439.0" y="4568.371"/> </arc> <arc class="production" id="prod_2d4ac0d4-4a55-478e-8cf2-d15ab3704b12" source="pr_fbb2d30a-fe29-47bd-ab7c-2d810e2f0adf_p2" target="wca1_s_wca3_s477_wca1_wca3_sa357"> <start x="14469.0" y="4568.371"/> <end x="14481.0" y="4568.6245"/> </arc> <arc class="consumption" id="cons_ceec54f8-f9d4-4245-b928-d0a251ead2dd" source="wca1_s_wca3_s478_wca1_wca3_sa358" target="pr_4802b935-9c25-4ae1-b968-36ad15f6a3d5_p1"> <start x="14190.0" y="4635.25"/> <end x="14241.5" y="4635.25"/> </arc> <arc class="production" id="prod_c830135d-3602-4ce1-810c-7fbe243ba4c4" source="pr_4802b935-9c25-4ae1-b968-36ad15f6a3d5_p2" target="wca1_s_wca3_s31_wca1_wca3_sa359"> <start x="14271.5" y="4635.25"/> <end x="14323.0" y="4635.25"/> </arc> <arc class="catalysis" id="modif_82bc40fd-7ff0-4832-927d-3c90c89b5080" source="wca1_s_wca3_s702_wca1_wca3_csa11" target="pr_4802b935-9c25-4ae1-b968-36ad15f6a3d5"> <start x="14248.875" y="4703.125"/> <end x="14256.5" y="4640.25"/> </arc> <arc class="inhibition" id="modif_acb66772-7e62-40e1-885b-fe2f34b157db" source="wca1_s_wca3_s804_wca1_wca3_csa22" target="pr_4802b935-9c25-4ae1-b968-36ad15f6a3d5"> <start x="14492.25" y="4448.5"/> <end x="14256.5" y="4630.25"/> </arc> <arc class="inhibition" id="modif_a098fa75-4e52-4da8-b07e-5e8a67277eb0" source="wca1_s_wca3_s491_wca1_wca3_csa59" target="pr_4802b935-9c25-4ae1-b968-36ad15f6a3d5"> <start x="14066.714" y="4015.5"/> <end x="14251.5" y="4630.25"/> </arc> <arc class="consumption" id="cons_79e15f4f-c0ed-4d83-aee1-e78afe2b80fc" source="wca1_s_wca3_s31_wca1_wca3_sa359" target="pr_7013f16e-f75b-4ce1-bb23-f20cf54de1a7_p1"> <start x="14413.0" y="4635.25"/> <end x="14432.5" y="4635.25"/> </arc> <arc class="production" id="prod_2e4e7eba-7937-496a-8580-226c5ca58b9e" source="pr_7013f16e-f75b-4ce1-bb23-f20cf54de1a7_p2" target="wca1_s_wca3_s479_wca1_wca3_sa360"> <start x="14462.5" y="4635.25"/> <end x="14482.0" y="4635.25"/> </arc> <arc class="consumption" id="cons_7c9dcfda-7703-4f42-82d8-83ead54de7e4" source="wca1_s_wca3_s104_wca1_wca3_sa94" target="pr_6b719eb7-5781-4fc5-a7fc-3f93941a8fc6_p1"> <start x="13986.214" y="3797.0"/> <next x="14197.0" y="3923.75"/> <end x="14192.107" y="3918.608"/> </arc> <arc class="consumption" id="cons_f0de599c-523b-4421-b7be-042f7846c290" source="wca1_s_wca3_s15_wca1_wca3_csa8" target="pr_6b719eb7-5781-4fc5-a7fc-3f93941a8fc6_p1"> <start x="14209.429" y="3897.5"/> <next x="14197.0" y="3923.75"/> <end x="14192.107" y="3918.608"/> </arc> <arc class="production" id="prod_34899053-92fb-46eb-93cf-e04443660204" source="pr_6b719eb7-5781-4fc5-a7fc-3f93941a8fc6_p2" target="wca1_s_wca3_s491_wca1_wca3_csa59"> <start x="14162.107" y="3918.608"/> <end x="14161.214" y="3914.5"/> </arc> <arc class="consumption" id="addreact_149d3cc0-8868-46ce-a455-78ec2c459dc5" source="wca1_s_wca3_s160_wca1_wca3_sa152" target="pr_6b719eb7-5781-4fc5-a7fc-3f93941a8fc6_p1"> <start x="14058.417" y="4141.5"/> <end x="14192.107" y="3918.608"/> </arc> <arc class="consumption" id="addreact_8ef45fb0-a30c-4f03-abf3-b033469b5f95" source="wca1_s_wca3_s364_wca1_wca3_sa278" target="pr_6b719eb7-5781-4fc5-a7fc-3f93941a8fc6_p1"> <start x="13199.0" y="4310.0"/> <end x="14192.107" y="3918.608"/> </arc> <arc class="consumption" id="addreact_09e24371-ed3c-43ed-9eb0-00422651b361" source="wca1_s_wca3_s387_wca1_wca3_sa292" target="pr_6b719eb7-5781-4fc5-a7fc-3f93941a8fc6_p1"> <start x="14211.5" y="4024.5"/> <end x="14192.107" y="3918.608"/> </arc> <arc class="consumption" id="cons_e5412ea5-ec72-4f53-94d9-83f1831b89ed" source="wca1_s_wca3_s800_wca1_wca3_csa7" target="pr_d7d10680-f3f5-4655-828e-c14b7d0e7d9f_p1"> <start x="14517.0" y="5141.0"/> <end x="14521.285" y="5171.0"/> </arc> <arc class="production" id="prod_40c0a401-663d-48a3-8ef9-0065a4163637" source="pr_d7d10680-f3f5-4655-828e-c14b7d0e7d9f_p2" target="wca1_s_wca3_s499_wca1_wca3_sa369"> <start x="14521.285" y="5201.0"/> <end x="14525.571" y="5231.0"/> </arc> <arc class="consumption" id="cons_f9bcb814-d404-4d91-ac9a-542b764d11a0" source="wca1_s_wca3_s799_wca1_wca3_csa60" target="pr_78d864de-0dc8-4cb5-8149-6febd17732d9_p1"> <start x="14364.0" y="5053.5"/> <end x="14439.149" y="5127.25"/> </arc> <arc class="production" id="prod_cacde454-6362-43cb-a85c-50256fe5e742" source="pr_78d864de-0dc8-4cb5-8149-6febd17732d9_p2" target="wca1_s_wca3_s499_wca1_wca3_sa369"> <start x="14439.149" y="5157.25"/> <end x="14514.299" y="5231.0"/> </arc> <arc class="consumption" id="cons_6a228498-78b5-428b-9411-5ebafab67264" source="wca1_s_wca3_s520_wca1_wca3_sa377" target="pr_19d51851-9e3b-4922-95ed-1cadc0316dc9_p1"> <start x="13230.0" y="5054.0"/> <end x="13230.25" y="5054.0"/> </arc> <arc class="production" id="prod_d0964fe0-1efb-4028-99a8-7a16e7905576" source="pr_19d51851-9e3b-4922-95ed-1cadc0316dc9_p2" target="wca1_s_wca3_s521_wca1_wca3_sa378"> <start x="13260.25" y="5054.0"/> <end x="13260.5" y="5054.0"/> </arc> <arc class="inhibition" id="modif_9498b068-7422-4a37-9323-63b911fc71a8" source="wca1_s_wca3_s799_wca1_wca3_csa60" target="pr_19d51851-9e3b-4922-95ed-1cadc0316dc9"> <start x="14182.0" y="5053.5"/> <end x="13245.25" y="5059.0"/> </arc> <arc class="consumption" id="cons_d5c3adf8-3e01-4899-bfb6-71bdf2cb7ff2" source="wca1_s_wca3_s215_wca1_wca3_sa169" target="pr_8209de09-98e1-415e-95bb-0d0a9ff31c4b_p1"> <start x="13333.5" y="4781.0"/> <next x="13426.0" y="4997.0"/> <end x="13454.0" y="4997.0"/> </arc> <arc class="consumption" id="cons_5c2d7ef5-de7a-479b-b2b1-aea37e8fe610" source="wca1_s_wca3_s521_wca1_wca3_sa378" target="pr_8209de09-98e1-415e-95bb-0d0a9ff31c4b_p1"> <start x="13338.0" y="5054.0"/> <next x="13426.0" y="4997.0"/> <end x="13454.0" y="4997.0"/> </arc> <arc class="production" id="prod_044b9d17-2203-4c70-a5e6-54f9c59029f2" source="pr_8209de09-98e1-415e-95bb-0d0a9ff31c4b_p2" target="wca1_s_wca3_s522_wca1_wca3_csa61"> <start x="13484.0" y="4997.0"/> <end x="13508.0" y="4997.0"/> </arc> <arc class="consumption" id="cons_bd726337-3c3b-434e-9409-edf3705569e0" source="wca1_s_wca3_s534_wca1_wca3_sa382" target="pr_29aa3ebe-016d-44df-8919-c71acdb77815_p1"> <start x="13472.0" y="5285.0"/> <end x="13482.5" y="5285.0"/> </arc> <arc class="production" id="prod_caa726b8-cea9-409d-bdd3-9800fa469072" source="pr_29aa3ebe-016d-44df-8919-c71acdb77815_p2" target="wca1_s_wca3_s533_wca1_wca3_sa381"> <start x="13512.5" y="5285.0"/> <end x="13523.0" y="5285.0"/> </arc> <arc class="inhibition" id="modif_33853043-434c-4b14-a986-7d7ad2b94ace" source="wca1_s_wca3_s799_wca1_wca3_csa60" target="pr_29aa3ebe-016d-44df-8919-c71acdb77815"> <start x="14182.0" y="5053.5"/> <end x="13497.5" y="5280.0"/> </arc> <arc class="consumption" id="cons_7cd17ec8-66c3-4f95-96af-c273ada969e1" source="wca1_s_wca3_s533_wca1_wca3_sa381" target="pr_5406fe28-0f29-46a1-b875-2ca02a766f51_p1"> <start x="13613.0" y="5284.8877"/> <end x="13647.5" y="5284.444"/> </arc> <arc class="production" id="prod_117d7462-dcf0-433c-8000-0a79410978c8" source="pr_5406fe28-0f29-46a1-b875-2ca02a766f51_p2" target="wca1_s_wca3_s535_wca1_wca3_sa383"> <start x="13677.5" y="5284.444"/> <end x="13712.0" y="5284.0"/> </arc> <arc class="consumption" id="cons_a6ad3736-3b23-47b0-bc01-db714e8fd055" source="wca1_s_wca3_s535_wca1_wca3_sa383" target="pr_528cc5a8-1350-40e4-8939-d9ab8a6a8cae_p1"> <start x="13792.0" y="5284.0"/> <next x="13841.0" y="5242.0"/> <end x="13854.5" y="5242.0"/> </arc> <arc class="consumption" id="cons_41ae4c55-8a70-479d-8372-47758f96482a" source="wca1_s_wca3_s190_wca1_wca3_sa150" target="pr_528cc5a8-1350-40e4-8939-d9ab8a6a8cae_p1"> <start x="14243.417" y="4181.5"/> <next x="13841.0" y="5242.0"/> <end x="13854.5" y="5242.0"/> </arc> <arc class="production" id="prod_63d0afba-a052-4732-a919-e9ffc8cdd633" source="pr_528cc5a8-1350-40e4-8939-d9ab8a6a8cae_p2" target="wca1_s_wca3_s536_wca1_wca3_csa62"> <start x="13884.5" y="5242.0"/> <end x="13894.0" y="5242.0"/> </arc> <arc class="consumption" id="cons_6ece8659-5750-474f-83d2-f3224e3c419e" source="wca1_s_wca3_s262_wca1_wca3_sa208" target="pr_512b7e32-f78a-44c7-8825-fbb54a81cb4f_p1"> <start x="14368.0" y="3664.0"/> <end x="14481.91" y="3783.5"/> </arc> <arc class="production" id="prod_aae863ba-c461-44e1-9205-84ee4c0edf69" source="pr_512b7e32-f78a-44c7-8825-fbb54a81cb4f_p2" target="wca1_s_wca3_s198_wca1_wca3_sa158"> <start x="14511.91" y="3783.5"/> <end x="14625.819" y="3903.0"/> </arc> <arc class="consumption" id="cons_3a923438-1bcd-47f6-8019-302420f25a5a" source="wca1_s_wca3_s190_wca1_wca3_sa150" target="pr_2e4259f7-65e0-4f87-8e70-d7e76a47f942_p1"> <start x="14283.417" y="4161.5"/> <next x="14439.0" y="3867.0"/> <end x="14443.0" y="3864.206"/> </arc> <arc class="consumption" id="cons_3807fc6d-024c-4f1a-9f4a-1b476bfccd48" source="wca1_s_wca3_s542_wca1_wca3_sa389" target="pr_2e4259f7-65e0-4f87-8e70-d7e76a47f942_p1"> <start x="14406.0" y="3826.0"/> <next x="14439.0" y="3867.0"/> <end x="14443.0" y="3864.206"/> </arc> <arc class="production" id="prod_ce7672d9-c283-4a26-8a50-050593f961c6" source="pr_2e4259f7-65e0-4f87-8e70-d7e76a47f942_p2" target="wca1_s_wca3_s543_wca1_wca3_csa63"> <start x="14473.0" y="3864.206"/> <end x="14473.0" y="3862.0"/> </arc> <arc class="consumption" id="cons_2602b7a3-ef7f-47f8-8d3b-e1aeae28a983" source="wca1_s_wca3_s550_wca1_wca3_sa392" target="pr_02b35021-f7ed-453e-ac83-54c59a3a61ad_p1"> <start x="14763.0" y="4258.0"/> <next x="14804.5" y="4298.0"/> <end x="14813.25" y="4298.0"/> </arc> <arc class="consumption" id="cons_15e11e72-6b91-4cc4-8721-6b7abcce6f04" source="wca1_s_wca3_s551_wca1_wca3_sa393" target="pr_02b35021-f7ed-453e-ac83-54c59a3a61ad_p1"> <start x="14765.0" y="4332.0"/> <next x="14804.5" y="4298.0"/> <end x="14813.25" y="4298.0"/> </arc> <arc class="production" id="prod_f69e5ad6-a3ed-4172-b03f-2b3133f21681" source="pr_02b35021-f7ed-453e-ac83-54c59a3a61ad_p2" target="wca1_s_wca3_s552_wca1_wca3_csa64"> <start x="14843.25" y="4298.0"/> <end x="14848.0" y="4298.0"/> </arc> <arc class="consumption" id="cons_d5ccce12-6576-4778-9045-04579d421b16" source="wca1_s_wca3_s364_wca1_wca3_sa278" target="pr_e06ae214-f0f9-43a7-9a42-d3be9cdba67c_p1"> <start x="13199.0" y="4310.0"/> <end x="13199.0" y="4296.0"/> </arc> <arc class="production" id="prod_e0d4793c-8fea-45b1-a22f-4075ec6f128f" source="pr_e06ae214-f0f9-43a7-9a42-d3be9cdba67c_p2" target="wca1_s_wca3_s556_wca1_wca3_sa397"> <start x="13199.0" y="4266.0"/> <end x="13199.0" y="4252.0"/> </arc> <arc class="catalysis" id="modif_f0e223ef-9ded-48c2-a8a0-a0dc0870de89" source="wca1_s_wca3_s555_wca1_wca3_sa396" target="pr_e06ae214-f0f9-43a7-9a42-d3be9cdba67c"> <start x="13633.0" y="4070.0"/> <end x="13204.0" y="4281.0"/> </arc> <arc class="consumption" id="cons_d43a2d24-a053-4ae2-9569-edb651148e22" source="wca1_s_wca3_s556_wca1_wca3_sa397" target="pr_88465643-55a3-4cf2-a150-30f55ad09ba7_p1"> <start x="13199.0" y="4212.0"/> <end x="13199.0" y="4217.5"/> </arc> <arc class="production" id="prod_8531bb60-6e4d-4f39-8af7-9ddecde52a1f" source="pr_88465643-55a3-4cf2-a150-30f55ad09ba7_p2" target="wca1_s_wca3_s557_wca1_wca3_sa398"> <start x="13199.0" y="4187.5"/> <end x="13199.0" y="4193.0"/> </arc> <arc class="stimulation" id="direct_ffd75cb5-cac9-4d48-bc1f-77e5098e344f" source="wca1_s_wca3_s555_wca1_wca3_sa396" target="wca1_s_wca3_s558_wca1_wca3_sa399"> <start x="13673.0" y="4080.0"/> <end x="13674.685" y="4160.0"/> </arc> <arc class="consumption" id="cons_cb7b63ca-75d2-4831-ba80-9b050228a89e" source="wca1_s_wca3_s153_wca1_wca3_sa135" target="pr_898e034e-ae86-4c8c-893e-56079252a17c_p1"> <start x="13576.0" y="3415.5"/> <end x="14082.453" y="3715.25"/> </arc> <arc class="production" id="prod_438612a7-3b57-40b5-bb1a-340e95be9e17" source="pr_898e034e-ae86-4c8c-893e-56079252a17c_p2" target="wca1_s_wca3_s260_wca1_wca3_sa207"> <start x="14112.453" y="3715.25"/> <end x="14618.905" y="4015.0"/> </arc> <arc class="consumption" id="cons_d41f7561-dc4a-453e-a80b-4b3e85deeee9" source="wca1_s_wca3_s5_wca1_wca3_sa5" target="pr_68b9f99a-0a1b-42d0-8f49-ce8094d45e03_p1"> <start x="14011.5" y="3697.0"/> <next x="13616.0" y="3966.0"/> <end x="13509.5" y="3966.0"/> </arc> <arc class="consumption" id="cons_1be5b0f0-9468-4e62-96b4-13e32b5ed755" source="wca1_s_wca3_s555_wca1_wca3_sa396" target="pr_68b9f99a-0a1b-42d0-8f49-ce8094d45e03_p1"> <start x="13633.0" y="4060.0"/> <next x="13616.0" y="3966.0"/> <end x="13509.5" y="3966.0"/> </arc> <arc class="production" id="prod_1320df31-7596-4075-a909-41392a317fc0" source="pr_68b9f99a-0a1b-42d0-8f49-ce8094d45e03_p2" target="wca1_s_wca3_s571_wca1_wca3_csa65"> <start x="13479.5" y="3966.0"/> <end x="13377.0" y="3966.0"/> </arc> <arc class="consumption" id="addreact_d859fe12-8e4c-423b-aaa9-f8ecd28fedb9" source="wca1_s_wca3_s364_wca1_wca3_sa278" target="pr_68b9f99a-0a1b-42d0-8f49-ce8094d45e03_p1"> <start x="13199.0" y="4310.0"/> <end x="13509.5" y="3966.0"/> </arc> <arc class="consumption" id="addreact_30ef5e4d-3dfc-481b-b2ed-896974fb5989" source="wca1_s_wca3_s160_wca1_wca3_sa152" target="pr_68b9f99a-0a1b-42d0-8f49-ce8094d45e03_p1"> <start x="14018.417" y="4161.5"/> <end x="13509.5" y="3966.0"/> </arc> <arc class="stimulation" id="direct_043053b0-b451-4bed-a6a5-92e92070a343" source="wca1_s_wca3_s555_wca1_wca3_sa396" target="wca1_s_wca3_s572_wca1_wca3_sa404"> <start x="13673.0" y="4080.0"/> <end x="13703.333" y="4101.0"/> </arc> <arc class="consumption" id="cons_277ca8d5-a555-4dc9-a237-5c77dcb9bd5c" source="wca1_s_wca3_s804_wca1_wca3_csa22" target="pr_dd03c7e3-9185-43f8-8730-850f2db489cc_p1"> <start x="14517.5" y="4308.25"/> <end x="14549.5" y="4277.5"/> </arc> <arc class="production" id="prod_2537c89f-e6f8-43fa-99cb-20a00fdaea6c" source="pr_dd03c7e3-9185-43f8-8730-850f2db489cc_p2" target="wca1_s_wca3_s806_wca1_wca3_csa66"> <start x="14549.5" y="4247.5"/> <end x="14581.5" y="4216.75"/> </arc> <arc class="catalysis" id="modif_d9247d16-455f-4ab2-b63a-b1441e6095d5" source="wca1_s_wca3_s555_wca1_wca3_sa396" target="pr_dd03c7e3-9185-43f8-8730-850f2db489cc"> <start x="13713.0" y="4060.0"/> <end x="14545.402" y="4259.6343"/> </arc> <arc class="consumption" id="cons_f33fd36e-1839-4ec1-989c-ebc5b69a37ea" source="wca1_s_wca3_s806_wca1_wca3_csa66" target="pr_cd4fcb0e-dfce-43e3-9465-064b6ef48c37_p1"> <start x="14581.5" y="4123.25"/> <end x="14536.875" y="4177.375"/> </arc> <arc class="production" id="prod_b7341708-81ef-4ca6-ab53-d5149819cb58" source="pr_cd4fcb0e-dfce-43e3-9465-064b6ef48c37_p2" target="wca1_s_wca3_s804_wca1_wca3_csa22"> <start x="14536.875" y="4207.375"/> <end x="14492.25" y="4261.5"/> </arc> <arc class="consumption" id="addreact_b03e2d78-8100-4cee-ace2-91ebafe85671" source="wca1_s_wca3_s160_wca1_wca3_sa152" target="pr_cd4fcb0e-dfce-43e3-9465-064b6ef48c37_p1"> <start x="14098.417" y="4181.5"/> <end x="14536.875" y="4177.375"/> </arc> <arc class="production" id="addprod_519b4849-4b78-400f-93b2-da60d08f7e4f" source="pr_cd4fcb0e-dfce-43e3-9465-064b6ef48c37_p2" target="wca1_s_wca3_s582_wca1_wca3_sa416"> <start x="14536.875" y="4207.375"/> <end x="14522.75" y="4106.0"/> </arc> <arc class="inhibition" id="direct_f45e9c88-c690-4694-ba46-bae0d3ecd7ce" source="wca1_s_wca3_s555_wca1_wca3_sa396" target="wca1_s_wca3_s583_wca1_wca3_sa417"> <start x="13653.0" y="4040.0"/> <end x="13622.51" y="3737.0"/> </arc> <arc class="consumption" id="cons_32e91b75-27c3-4156-9a65-13ae1ec584eb" source="wca1_s_wca3_s5_wca1_wca3_sa5" target="pr_a17c7b93-7bbf-4a1d-b726-b3e5635b094e_p1"> <start x="13971.5" y="3677.0"/> <end x="13962.25" y="3676.5"/> </arc> <arc class="production" id="prod_53f56b5e-5838-47fe-9740-d5123ac5c012" source="pr_a17c7b93-7bbf-4a1d-b726-b3e5635b094e_p2" target="wca1_s_wca3_s588_wca1_wca3_sa418"> <start x="13932.25" y="3676.5"/> <end x="13923.0" y="3676.0"/> </arc> <arc class="catalysis" id="modif_11af3923-e112-4c5e-8294-bd6a55c70ac4" source="wca1_s_wca3_s555_wca1_wca3_sa396" target="pr_a17c7b93-7bbf-4a1d-b726-b3e5635b094e"> <start x="13673.0" y="4040.0"/> <end x="13947.146" y="3681.499"/> </arc> <arc class="consumption" id="cons_4c898b60-80c3-4b5a-b336-67261fce89b8" source="wca1_s_wca3_s588_wca1_wca3_sa418" target="pr_c49e08d6-8e12-45bf-94bc-89cba1e94f3c_p1"> <start x="13883.0" y="3696.0"/> <end x="13833.097" y="3859.5"/> </arc> <arc class="production" id="prod_c4f36438-c9a9-4cb8-887e-53e5a42761d3" source="pr_c49e08d6-8e12-45bf-94bc-89cba1e94f3c_p2" target="wca1_s_wca3_s189_wca1_wca3_sa149"> <start x="13833.097" y="3889.5"/> <end x="13783.193" y="4053.0"/> </arc> <arc class="consumption" id="cons_e328d1ff-9632-43fb-b3c2-d95ea07a8e5f" source="wca1_s_wca3_s607_wca1_wca3_sa432" target="pr_8e0853b8-a486-43e1-a723-75d715c1c74f_p1"> <start x="14768.0" y="5217.25"/> <end x="14805.0" y="5217.125"/> </arc> <arc class="production" id="prod_311a132c-19f0-45fb-a6e4-b8ccbfe01f61" source="pr_8e0853b8-a486-43e1-a723-75d715c1c74f_p2" target="wca1_s_wca3_s609_wca1_wca3_sa433"> <start x="14835.0" y="5217.125"/> <end x="14872.0" y="5217.0"/> </arc> <arc class="catalysis" id="logicarc_ebd89da9-c8d6-4c9a-96eb-43cdd24bbe2a" source="logicglyph_e85e24b2-b34c-4175-bf80-70eadd8bce61_p2" target="pr_8e0853b8-a486-43e1-a723-75d715c1c74f"> <start x="14819.043" y="5187.245"/> <end x="14819.988" y="5212.125"/> </arc> <arc class="logic arc" id="modif_6871f8f4-d534-456b-bffa-0ad5946b406d" source="wca1_s_wca3_s801_wca1_wca3_csa67" target="logicglyph_e85e24b2-b34c-4175-bf80-70eadd8bce61_p1"> <start x="14836.5" y="5112.0"/> <end x="14819.043" y="5147.245"/> </arc> <arc class="logic arc" id="modif_5f4eea15-19cc-497a-b24c-880707a4479f" source="wca1_s_wca3_s187_wca1_wca3_sa434" target="logicglyph_e85e24b2-b34c-4175-bf80-70eadd8bce61_p1"> <start x="14766.0" y="5139.0"/> <end x="14819.043" y="5147.245"/> </arc> <arc class="logic arc" id="modif_ef530f03-59df-4671-bf1f-429bb5ef1210" source="wca1_s_wca3_s608_wca1_wca3_sa435" target="logicglyph_e85e24b2-b34c-4175-bf80-70eadd8bce61_p1"> <start x="14893.0" y="5142.0"/> <end x="14819.043" y="5147.245"/> </arc> <arc class="consumption" id="cons_12c1dac3-208c-43ed-b79a-bd68e63012e2" source="wca1_s_wca3_s609_wca1_wca3_sa433" target="pr_3c159b35-5461-4a6d-80e7-f0f4daf46d11_p1"> <start x="14952.0" y="5217.0"/> <end x="14962.0" y="5216.7114"/> </arc> <arc class="production" id="prod_38718677-5ff4-4b0f-a009-07bf37bbc94c" source="pr_3c159b35-5461-4a6d-80e7-f0f4daf46d11_p2" target="wca1_s_wca3_s610_wca1_wca3_sa436"> <start x="14992.0" y="5216.7114"/> <end x="15002.0" y="5216.423"/> </arc> <arc class="consumption" id="cons_0c77b401-7597-4ca2-b305-ceb2a8e5a7dc" source="wca1_s_wca3_s801_wca1_wca3_csa67" target="pr_ee98f11a-2f45-47e0-b97b-9bd5812d521d_p1"> <start x="15012.0" y="5004.0"/> <end x="15076.0" y="5003.601"/> </arc> <arc class="production" id="prod_7943f3ab-81a4-44fb-be95-ad773d0b1309" source="pr_ee98f11a-2f45-47e0-b97b-9bd5812d521d_p2" target="wca1_s_wca3_s624_wca1_wca3_sa437"> <start x="15106.0" y="5003.601"/> <end x="15170.0" y="5003.202"/> </arc> <arc class="consumption" id="cons_d85fe04e-e749-4e94-9fd2-712659e7fb8a" source="wca1_s_wca3_s615_wca1_wca3_sa438" target="pr_100d36b3-cf89-419c-98e8-0fa19edef1b9_p1"> <start x="14080.0" y="5214.0"/> <end x="14090.5" y="5214.0"/> </arc> <arc class="production" id="prod_f39dea0d-e657-422d-8775-3c0c0163db2b" source="pr_100d36b3-cf89-419c-98e8-0fa19edef1b9_p2" target="wca1_s_wca3_s616_wca1_wca3_sa439"> <start x="14120.5" y="5214.0"/> <end x="14131.0" y="5214.0"/> </arc> <arc class="catalysis" id="modif_ca3dee70-0f8f-435a-8387-bdec87438e7c" source="wca1_s_wca3_s617_wca1_wca3_sa440" target="pr_100d36b3-cf89-419c-98e8-0fa19edef1b9"> <start x="14001.0" y="5101.0"/> <end x="14105.5" y="5209.0"/> </arc> <arc class="catalysis" id="modif_86e595e5-7a71-49d3-bffd-49436050db6c" source="wca1_s_wca3_s705_wca1_wca3_csa3" target="pr_100d36b3-cf89-419c-98e8-0fa19edef1b9"> <start x="14007.0" y="4692.125"/> <end x="14110.5" y="5209.0"/> </arc> <arc class="consumption" id="cons_583400ad-2b62-4fe2-97b4-6e548d38ab15" source="wca1_s_wca3_s618_wca1_wca3_sa441" target="pr_52f9210c-9e09-4ff8-8db9-bb8c09b94772_p1"> <start x="14080.0" y="5256.0"/> <end x="14090.5" y="5256.0"/> </arc> <arc class="production" id="prod_6b2eda0d-b59b-40c8-ad6e-104bf2adc25d" source="pr_52f9210c-9e09-4ff8-8db9-bb8c09b94772_p2" target="wca1_s_wca3_s619_wca1_wca3_sa442"> <start x="14120.5" y="5256.0"/> <end x="14131.0" y="5256.0"/> </arc> <arc class="catalysis" id="modif_64113aac-d4df-4ce3-ba4e-62c69c3e63db" source="wca1_s_wca3_s705_wca1_wca3_csa3" target="pr_52f9210c-9e09-4ff8-8db9-bb8c09b94772"> <start x="14007.0" y="4692.125"/> <end x="14105.5" y="5251.0"/> </arc> <arc class="stimulation" id="direct_2eac85df-4fb4-49a0-bb69-0ed1cbddb170" source="wca1_s_wca3_s625_wca1_wca3_sa443" target="wca1_s_wca3_s801_wca1_wca3_csa67"> <start x="15155.0" y="4924.9946"/> <end x="15012.0" y="4950.0"/> </arc> <arc class="consumption" id="cons_86585033-d61a-44c7-8e96-0eb86ba7c6b0" source="wca1_s_wca3_s630_wca1_wca3_sa444" target="pr_a513fbac-1128-48b3-99c4-a1369fb4b16c_p1"> <start x="14319.0" y="5171.0"/> <end x="14323.5" y="5171.0"/> </arc> <arc class="production" id="prod_e7fc5f44-60ba-462f-afb7-8af33e360722" source="pr_a513fbac-1128-48b3-99c4-a1369fb4b16c_p2" target="wca1_s_wca3_s631_wca1_wca3_sa445"> <start x="14353.5" y="5171.0"/> <end x="14358.0" y="5171.0"/> </arc> <arc class="catalysis" id="modif_ceefb839-a5fd-4547-be9f-ca12f0260a3f" source="wca1_s_wca3_s705_wca1_wca3_csa3" target="pr_a513fbac-1128-48b3-99c4-a1369fb4b16c"> <start x="14007.0" y="4692.125"/> <end x="14338.5" y="5166.0"/> </arc> <arc class="consumption" id="cons_43eac5b6-5eb2-4dab-8371-225e7ee8a525" source="wca1_s_wca3_s521_wca1_wca3_sa378" target="pr_d09c660b-4e04-48a2-83e2-f4fc7fda65e2_p1"> <start x="13350.5" y="5055.5117"/> <end x="14004.25" y="5136.381"/> </arc> <arc class="production" id="prod_b89dd31f-b3f2-492c-a6e9-497dbcd40560" source="pr_d09c660b-4e04-48a2-83e2-f4fc7fda65e2_p2" target="wca1_s_wca3_s607_wca1_wca3_sa432"> <start x="14034.25" y="5136.381"/> <end x="14688.0" y="5217.25"/> </arc> <arc class="consumption" id="cons_c335fb95-9d7b-4ec7-8309-572860fedcf0" source="wca1_s_wca3_s644_wca1_wca3_sa446" target="pr_5fb8ba47-ba94-4343-b732-26cc2a1277eb_p1"> <start x="13230.0" y="5092.0"/> <end x="13230.25" y="5092.0"/> </arc> <arc class="production" id="prod_f5ff0c7e-89ae-41bb-8afa-18e025c12ad1" source="pr_5fb8ba47-ba94-4343-b732-26cc2a1277eb_p2" target="wca1_s_wca3_s646_wca1_wca3_sa448"> <start x="13260.25" y="5092.0"/> <end x="13260.5" y="5092.0"/> </arc> <arc class="catalysis" id="modif_d3b9507e-4813-4067-86d6-c937f1d10210" source="wca1_s_wca3_s702_wca1_wca3_csa11" target="pr_5fb8ba47-ba94-4343-b732-26cc2a1277eb"> <start x="14089.875" y="4828.125"/> <end x="13245.25" y="5087.0"/> </arc> <arc class="consumption" id="cons_e907cabc-4c6d-4100-ae43-9d4de6965ee7" source="wca1_s_wca3_s645_wca1_wca3_sa447" target="pr_fb67ae16-c59c-4c91-893f-fe693a7b9693_p1"> <start x="13230.0" y="5129.0"/> <end x="13230.25" y="5129.0"/> </arc> <arc class="production" id="prod_c64a5e34-b358-4375-af13-45472e54d989" source="pr_fb67ae16-c59c-4c91-893f-fe693a7b9693_p2" target="wca1_s_wca3_s647_wca1_wca3_sa449"> <start x="13260.25" y="5129.0"/> <end x="13260.5" y="5129.0"/> </arc> <arc class="catalysis" id="modif_b718cb82-017b-4617-8966-0dc4c751b2a0" source="wca1_s_wca3_s702_wca1_wca3_csa11" target="pr_fb67ae16-c59c-4c91-893f-fe693a7b9693"> <start x="14089.875" y="4828.125"/> <end x="13245.25" y="5124.0"/> </arc> <arc class="consumption" id="cons_e1da8641-4624-4250-b502-b84590e2101c" source="wca1_s_wca3_s646_wca1_wca3_sa448" target="pr_f6aa8f26-651c-403f-97ec-32ee18353260_p1"> <start x="13338.0" y="5092.0"/> <next x="13370.0" y="5116.0"/> <end x="13366.5" y="5116.0"/> </arc> <arc class="consumption" id="cons_2f564de2-b6ae-42a8-817f-4be6296e3682" source="wca1_s_wca3_s142_wca1_wca3_sa110" target="pr_f6aa8f26-651c-403f-97ec-32ee18353260_p1"> <start x="13354.5" y="5230.0"/> <next x="13370.0" y="5116.0"/> <end x="13366.5" y="5116.0"/> </arc> <arc class="production" id="prod_ff5edd62-30e3-4da4-a59f-761bbc35019e" source="pr_f6aa8f26-651c-403f-97ec-32ee18353260_p2" target="wca1_s_wca3_s654_wca1_wca3_csa68"> <start x="13396.5" y="5116.0"/> <end x="13389.0" y="5116.0"/> </arc> <arc class="consumption" id="cons_71e332ab-e36d-4bce-8111-396241ec3779" source="wca1_s_wca3_s647_wca1_wca3_sa449" target="pr_e2ae200b-28db-4c19-8012-cadeb9731603_p1"> <start x="13338.0" y="5129.0"/> <next x="13384.0" y="5128.5"/> <end x="13437.0" y="5121.0303"/> </arc> <arc class="consumption" id="cons_d4074c20-54f7-4f60-b05b-73286e7d7f5b" source="wca1_s_wca3_s142_wca1_wca3_sa110" target="pr_e2ae200b-28db-4c19-8012-cadeb9731603_p1"> <start x="13354.5" y="5230.0"/> <next x="13384.0" y="5128.5"/> <end x="13437.0" y="5121.0303"/> </arc> <arc class="production" id="prod_dd448220-515b-4723-9316-c0ca5e2e99be" source="pr_e2ae200b-28db-4c19-8012-cadeb9731603_p2" target="wca1_s_wca3_s651_wca1_wca3_csa69"> <start x="13467.0" y="5121.0303"/> <end x="13516.0" y="5114.0"/> </arc> <arc class="consumption" id="cons_c5f1a315-e6a3-4fba-91ed-010f44bca243" source="wca1_s_wca3_s659_wca1_wca3_sa454" target="pr_86017df2-c98e-424f-b205-cd05a38ff4c7_p1"> <start x="14319.0" y="5216.0"/> <end x="14323.5" y="5216.0"/> </arc> <arc class="production" id="prod_1d3a3346-fc22-4a8d-a8d2-393a7571c8e0" source="pr_86017df2-c98e-424f-b205-cd05a38ff4c7_p2" target="wca1_s_wca3_s660_wca1_wca3_sa455"> <start x="14353.5" y="5216.0"/> <end x="14358.0" y="5216.0"/> </arc> <arc class="catalysis" id="modif_c876d038-3910-4785-a18b-dde173be613d" source="wca1_s_wca3_s702_wca1_wca3_csa11" target="pr_86017df2-c98e-424f-b205-cd05a38ff4c7"> <start x="14195.875" y="4953.125"/> <end x="14338.5" y="5211.0"/> </arc> <arc class="consumption" id="cons_3d5b2823-978d-4fac-b7af-e1bec873d636" source="wca1_s_wca3_s660_wca1_wca3_sa455" target="pr_0029f063-287e-4adf-8cb9-91fc7f3e532c_p1"> <start x="14390.5" y="5228.5"/> <end x="14326.37" y="5364.75"/> </arc> <arc class="production" id="prod_dc44818d-5f47-4ca3-bfc0-34ecdf2e7c12" source="pr_0029f063-287e-4adf-8cb9-91fc7f3e532c_p2" target="wca1_s_wca3_s661_wca1_wca3_sa456"> <start x="14326.37" y="5394.75"/> <end x="14262.24" y="5531.0"/> </arc> <arc class="stimulation" id="direct_2fb092ca-c7fd-491b-a310-76badd918a73" source="wca1_s_wca3_s661_wca1_wca3_sa456" target="wca1_s_wca3_s662_wca1_wca3_sa457"> <start x="14298.0" y="5551.0"/> <end x="14396.0" y="5519.7534"/> </arc> <arc class="consumption" id="cons_38d91313-fee6-4d2e-abec-3506ef97c64d" source="wca1_s_wca3_s663_wca1_wca3_sa458" target="pr_1cf8c549-8968-4f65-b4c5-775bbded12cf_p1"> <start x="14319.0" y="5258.0"/> <end x="14323.5" y="5258.0"/> </arc> <arc class="production" id="prod_3ec5e699-ef4d-4f21-83c1-3626a0a59c97" source="pr_1cf8c549-8968-4f65-b4c5-775bbded12cf_p2" target="wca1_s_wca3_s664_wca1_wca3_sa459"> <start x="14353.5" y="5258.0"/> <end x="14358.0" y="5258.0"/> </arc> <arc class="catalysis" id="modif_c60a6af2-c6fe-401c-9c7a-0cd9f0e39e9f" source="wca1_s_wca3_s705_wca1_wca3_csa3" target="pr_1cf8c549-8968-4f65-b4c5-775bbded12cf"> <start x="14007.0" y="4692.125"/> <end x="14338.5" y="5253.0"/> </arc> <arc class="consumption" id="cons_9bc689d7-023e-47a2-bc9a-746632405d9f" source="wca1_s_wca3_s551_wca1_wca3_sa393" target="pr_6ad19127-d4c3-411e-9236-236fd4ebd13d_p1"> <start x="14765.0" y="4342.0"/> <end x="14953.5" y="4366.0"/> </arc> <arc class="production" id="prod_acdfd2ec-3fb8-4977-90e1-f8f6354bd433" source="pr_6ad19127-d4c3-411e-9236-236fd4ebd13d_p2" target="wca1_s_wca3_s670_wca1_wca3_sa462"> <start x="14983.5" y="4366.0"/> <end x="15172.0" y="4390.0"/> </arc> <arc class="consumption" id="cons_4c0eaa8f-11a4-4ab9-a23a-719ab2d3f8e3" source="wca1_s_wca3_s670_wca1_wca3_sa462" target="pr_ca2f1a48-5836-4e47-8d98-b211492b1370_p1"> <start x="15172.0" y="4370.0"/> <end x="14983.5" y="4346.0"/> </arc> <arc class="production" id="prod_9097c524-6caa-421a-b6ab-6611d5dc70b9" source="pr_ca2f1a48-5836-4e47-8d98-b211492b1370_p2" target="wca1_s_wca3_s551_wca1_wca3_sa393"> <start x="14953.5" y="4346.0"/> <end x="14765.0" y="4322.0"/> </arc> <arc class="catalysis" id="modif_fc9d7ffc-b8a7-46b4-813e-44559590fcbf" source="wca1_s_wca3_s213_wca1_wca3_sa167" target="pr_ca2f1a48-5836-4e47-8d98-b211492b1370"> <start x="14382.0" y="4232.0"/> <end x="14969.086" y="4341.034"/> </arc> <arc class="consumption" id="cons_beb56a03-ee31-49f0-889c-87b1817c511b" source="wca1_s_wca3_s675_wca1_wca3_sa463" target="pr_e6018a0b-4a36-48b7-abf1-5adb88ab5d3c_p1"> <start x="14593.0" y="4352.0"/> <next x="14663.0" y="4376.75"/> <end x="14663.0" y="4378.375"/> </arc> <arc class="consumption" id="cons_1de32ae7-bdae-4182-b814-2696ce70a842" source="wca1_s_wca3_s551_wca1_wca3_sa393" target="pr_e6018a0b-4a36-48b7-abf1-5adb88ab5d3c_p1"> <start x="14725.0" y="4352.0"/> <next x="14663.0" y="4376.75"/> <end x="14663.0" y="4378.375"/> </arc> <arc class="production" id="prod_3fdb2ef5-cbb6-40bc-96c3-37b4f4a6812a" source="pr_e6018a0b-4a36-48b7-abf1-5adb88ab5d3c_p2" target="wca1_s_wca3_s677_wca1_wca3_csa70"> <start x="14663.0" y="4408.375"/> <end x="14663.0" y="4406.0"/> </arc> <arc class="catalysis" id="modif_92e24faf-5cde-40fc-af1a-a9730b8b9499" source="wca1_s_wca3_s213_wca1_wca3_sa167" target="pr_e6018a0b-4a36-48b7-abf1-5adb88ab5d3c"> <start x="14371.373" y="4247.0"/> <end x="14658.0" y="4393.375"/> </arc> <arc class="consumption" id="cons_a3a2be44-afde-4f77-bc98-cc93675dfb16" source="wca1_s_wca3_s85_wca1_wca3_csa2" target="pr_a0ca0dc7-87c4-492c-8562-c0b39f398ebe_p1"> <start x="13563.0" y="4014.0"/> <next x="13563.125" y="4074.5"/> <end x="13556.452" y="4087.0"/> </arc> <arc class="consumption" id="cons_407ae067-0cde-4ee5-90e2-fc499aeb3496" source="wca1_s_wca3_s677_wca1_wca3_csa70" target="pr_a0ca0dc7-87c4-492c-8562-c0b39f398ebe_p1"> <start x="14613.0" y="4466.0"/> <next x="13563.125" y="4074.5"/> <end x="13556.452" y="4087.0"/> </arc> <arc class="production" id="prod_6747e6c3-e3d6-4320-b28d-deef6b548f08" source="pr_a0ca0dc7-87c4-492c-8562-c0b39f398ebe_p2" target="wca1_s_wca3_s687_wca1_wca3_csa71"> <start x="13556.452" y="4117.0"/> <end x="13550.75" y="4125.5"/> </arc> <arc class="consumption" id="cons_ae124702-866d-4d21-bb11-d57e504057ef" source="wca1_s_wca3_s677_wca1_wca3_csa70" target="pr_2b3852f8-4c4f-4f18-8981-5dc524b661cc_p1"> <start x="14713.0" y="4466.0"/> <next x="15038.085" y="3996.5"/> <end x="15040.348" y="4002.0"/> </arc> <arc class="consumption" id="cons_7a0c4808-c343-404a-a98d-14c569fc3516" source="wca1_s_wca3_s93_wca1_wca3_csa10" target="pr_2b3852f8-4c4f-4f18-8981-5dc524b661cc_p1"> <start x="15034.84" y="3969.0"/> <next x="15038.085" y="3996.5"/> <end x="15040.348" y="4002.0"/> </arc> <arc class="production" id="prod_49fd7feb-2b12-4f55-b26f-946f8a7c2385" source="pr_2b3852f8-4c4f-4f18-8981-5dc524b661cc_p2" target="wca1_s_wca3_s696_wca1_wca3_csa72"> <start x="15040.348" y="4032.0"/> <end x="15042.17" y="4033.5"/> </arc> <arc class="consumption" id="cons_5195787b-f537-472a-9340-ed96d0e4730e" source="wca1_s_wca4_s2_wca1_wca4_sa2" target="pr_fe7d2a25-9a29-4f22-97b7-dbe04ec2e7a1_p1"> <start x="15612.0" y="3193.0"/> <next x="15677.0" y="3210.6875"/> <end x="15677.0" y="3219.3438"/> </arc> <arc class="consumption" id="cons_ecbbf33e-6199-409f-8046-64df7f761e40" source="wca1_s_wca4_s1_wca1_wca4_sa1" target="pr_fe7d2a25-9a29-4f22-97b7-dbe04ec2e7a1_p1"> <start x="15737.0" y="3194.0"/> <next x="15677.0" y="3210.6875"/> <end x="15677.0" y="3219.3438"/> </arc> <arc class="production" id="prod_71c9847c-9f62-44d9-a31c-a9b5575d4a8e" source="pr_fe7d2a25-9a29-4f22-97b7-dbe04ec2e7a1_p2" target="wca1_s_wca4_s5_wca1_wca4_csa1"> <start x="15677.0" y="3249.3438"/> <end x="15677.0" y="3254.0"/> </arc> <arc class="consumption" id="cons_87f0cf73-5841-48b0-a29c-efc594cb2bd0" source="wca1_s_wca4_s5_wca1_wca4_csa1" target="pr_760dfbaa-421f-4b2f-b989-9229f573aa1f_p1"> <start x="15677.0" y="3374.0"/> <end x="15704.0" y="3403.0"/> </arc> <arc class="production" id="prod_4e5ad13d-ca27-426f-846e-6cec83cf08dd" source="pr_760dfbaa-421f-4b2f-b989-9229f573aa1f_p2" target="wca1_s_wca4_s8_wca1_wca4_csa2"> <start x="15704.0" y="3433.0"/> <end x="15731.0" y="3462.0"/> </arc> <arc class="consumption" id="cons_16f5f6af-97a8-4e3a-9fef-37d2fbb32671" source="wca1_s_wca4_s8_wca1_wca4_csa2" target="pr_15a4fd3c-299a-4319-b171-52fcd6aca398_p1"> <start x="15781.0" y="3522.0"/> <next x="15798.0" y="3522.0"/> <end x="15827.0" y="3522.262"/> </arc> <arc class="consumption" id="cons_40683fd2-f311-4565-bb4f-7f61f193e766" source="wca1_s_wca4_s13_wca1_wca4_csa3" target="pr_15a4fd3c-299a-4319-b171-52fcd6aca398_p1"> <start x="15781.0" y="3667.0"/> <next x="15798.0" y="3522.0"/> <end x="15827.0" y="3522.262"/> </arc> <arc class="production" id="prod_91d8139a-075a-446e-b8be-93f8747473de" source="pr_15a4fd3c-299a-4319-b171-52fcd6aca398_p2" target="wca1_s_wca4_s19_wca1_wca4_csa4"> <start x="15857.0" y="3522.262"/> <end x="15882.0" y="3522.5"/> </arc> <arc class="consumption" id="cons_259ec4f4-6fd7-4c70-b912-b36def57f11b" source="wca1_s_wca4_s20_wca1_wca4_sa13" target="pr_91ba47fe-9895-4468-9be6-d260b8ab4a9c_p1"> <start x="15938.0" y="3675.0"/> <end x="15952.0" y="3675.0"/> </arc> <arc class="production" id="prod_2812fc94-0717-45c5-ad4c-3227fb804750" source="pr_91ba47fe-9895-4468-9be6-d260b8ab4a9c_p2" target="wca1_s_wca4_s21_wca1_wca4_sa14"> <start x="15982.0" y="3675.0"/> <end x="15996.0" y="3675.0"/> </arc> <arc class="catalysis" id="modif_6731b55f-5c7d-443d-bafa-cc4d68195721" source="wca1_s_wca4_s19_wca1_wca4_csa4" target="pr_91ba47fe-9895-4468-9be6-d260b8ab4a9c"> <start x="15973.5" y="3586.0"/> <end x="15967.0" y="3670.0"/> </arc> <arc class="catalysis" id="modif_d6e331e5-22e0-4c88-8ac7-c58b104f66b3" source="wca1_s_wca4_s85_wca1_wca4_sa73" target="pr_91ba47fe-9895-4468-9be6-d260b8ab4a9c"> <start x="16065.0" y="3617.0"/> <end x="15972.0" y="3670.0"/> </arc> <arc class="consumption" id="cons_6c71147c-3111-452f-bbe8-178d91f9e5ab" source="wca1_s_wca4_s22_wca1_wca4_sa15" target="pr_2aa71bf8-fb17-4568-969d-2667eae17ed6_p1"> <start x="15776.0" y="5241.0"/> <end x="15788.0" y="5241.0"/> </arc> <arc class="production" id="prod_05df7b09-8e45-4e5d-92fb-04c522804e7f" source="pr_2aa71bf8-fb17-4568-969d-2667eae17ed6_p2" target="wca1_s_wca4_s23_wca1_wca4_sa16"> <start x="15818.0" y="5241.0"/> <end x="15830.0" y="5241.0"/> </arc> <arc class="consumption" id="cons_f6837efa-c4c7-4cb0-931a-f574a5dfe094" source="wca1_s_wca4_s24_wca1_wca4_sa17" target="pr_ff6afae8-4ec4-4b9b-ab0d-b95f85eb3ef3_p1"> <start x="16016.0" y="5241.0"/> <end x="16019.0" y="5241.0"/> </arc> <arc class="production" id="prod_2c3be5d4-7b5a-4d76-b3de-3967bd2e0a1c" source="pr_ff6afae8-4ec4-4b9b-ab0d-b95f85eb3ef3_p2" target="wca1_s_wca4_s25_wca1_wca4_sa18"> <start x="16049.0" y="5241.0"/> <end x="16052.0" y="5241.0"/> </arc> <arc class="consumption" id="cons_74aef101-b623-4a29-8b0f-ff9b6ea5c32c" source="wca1_s_wca4_s23_wca1_wca4_sa16" target="pr_b3201b8f-c708-4ee2-8398-d93c4bb094be_p1"> <start x="15907.5" y="5241.0"/> <next x="16109.0" y="5126.5"/> <end x="16135.5" y="5126.7627"/> </arc> <arc class="consumption" id="cons_a472d703-cc05-4eec-ba06-cf13ce7ab5b8" source="wca1_s_wca4_s25_wca1_wca4_sa18" target="pr_b3201b8f-c708-4ee2-8398-d93c4bb094be_p1"> <start x="16109.5" y="5228.5"/> <next x="16109.0" y="5126.5"/> <end x="16135.5" y="5126.7627"/> </arc> <arc class="production" id="prod_8c21b7de-9553-4d52-af2c-74b8ad3f7630" source="pr_b3201b8f-c708-4ee2-8398-d93c4bb094be_p2" target="wca1_s_wca4_s26_wca1_wca4_csa5"> <start x="16165.5" y="5126.7627"/> <end x="16188.0" y="5127.0"/> </arc> <arc class="consumption" id="cons_1f9ce838-f234-49d3-967c-a40a3c0af542" source="wca1_s_wca4_s29_wca1_wca4_sa21" target="pr_e1d993bb-9848-4089-a1b1-866faf763e5e_p1"> <start x="16016.0" y="5199.0"/> <end x="16019.0" y="5199.0"/> </arc> <arc class="production" id="prod_aa9e5c96-7550-4527-a0b0-a8debae93bff" source="pr_e1d993bb-9848-4089-a1b1-866faf763e5e_p2" target="wca1_s_wca4_s30_wca1_wca4_sa22"> <start x="16049.0" y="5199.0"/> <end x="16052.0" y="5199.0"/> </arc> <arc class="consumption" id="cons_855058f7-9489-41ff-9e8d-b870cc638f12" source="wca1_s_wca4_s31_wca1_wca4_sa23" target="pr_85270fc8-bffb-4848-8e95-53cbdd46f804_p1"> <start x="15776.0" y="5207.0"/> <end x="15788.0" y="5207.0"/> </arc> <arc class="production" id="prod_ccedf699-a7b8-4e69-9be5-b164077a1bf4" source="pr_85270fc8-bffb-4848-8e95-53cbdd46f804_p2" target="wca1_s_wca4_s32_wca1_wca4_sa24"> <start x="15818.0" y="5207.0"/> <end x="15830.0" y="5207.0"/> </arc> <arc class="consumption" id="cons_016dbe9c-5cca-4325-8451-67f4fbbe391d" source="wca1_s_wca4_s36_wca1_wca4_sa27" target="pr_36ae4928-8b49-43c1-8985-69db19d269e0_p1"> <start x="16016.0" y="5164.0"/> <end x="16019.0" y="5164.0"/> </arc> <arc class="production" id="prod_1fdc194e-66d8-4a26-97dd-a0645b6bcf9e" source="pr_36ae4928-8b49-43c1-8985-69db19d269e0_p2" target="wca1_s_wca4_s37_wca1_wca4_sa28"> <start x="16049.0" y="5164.0"/> <end x="16052.0" y="5164.0"/> </arc> <arc class="consumption" id="cons_24ed0841-b272-4b8f-a9c2-015071e9fe1e" source="wca1_s_wca4_s32_wca1_wca4_sa24" target="pr_983433a5-5f87-4a71-9ae4-671fa352786c_p1"> <start x="15907.5" y="5207.0"/> <next x="16118.0" y="5115.492"/> <end x="16118.275" y="5109.246"/> </arc> <arc class="consumption" id="cons_029b8d18-e545-41b7-a930-e0a436fe26ce" source="wca1_s_wca4_s37_wca1_wca4_sa28" target="pr_983433a5-5f87-4a71-9ae4-671fa352786c_p1"> <start x="16129.5" y="5164.0"/> <next x="16118.0" y="5115.492"/> <end x="16118.275" y="5109.246"/> </arc> <arc class="production" id="prod_a1d1b4bd-eeee-4857-9339-843df2b662f2" source="pr_983433a5-5f87-4a71-9ae4-671fa352786c_p2" target="wca1_s_wca4_s38_wca1_wca4_csa7"> <start x="16118.275" y="5079.246"/> <end x="16118.5" y="5077.0"/> </arc> <arc class="consumption" id="cons_9776b4e2-3e66-4b12-a525-659cd1c9844e" source="wca1_s_wca4_s32_wca1_wca4_sa24" target="pr_3af11b5f-47ab-41b7-902e-e73e83409ce3_p1"> <start x="15907.5" y="5207.0"/> <next x="16163.0" y="5107.5"/> <end x="16176.171" y="5083.25"/> </arc> <arc class="consumption" id="cons_e0e89a69-4b19-49b6-ba20-9b8f4e725d7f" source="wca1_s_wca4_s30_wca1_wca4_sa22" target="pr_3af11b5f-47ab-41b7-902e-e73e83409ce3_p1"> <start x="16129.5" y="5199.0"/> <next x="16163.0" y="5107.5"/> <end x="16176.171" y="5083.25"/> </arc> <arc class="production" id="prod_649e443f-d45d-455e-8e4f-83163ede669c" source="pr_3af11b5f-47ab-41b7-902e-e73e83409ce3_p2" target="wca1_s_wca4_s33_wca1_wca4_csa6"> <start x="16176.171" y="5053.25"/> <end x="16188.0" y="5033.0"/> </arc> <arc class="consumption" id="cons_5f9af7fe-5d39-41b0-972a-d3335b222e6b" source="wca1_s_wca4_s38_wca1_wca4_csa7" target="pr_cda32f18-7c46-4147-9c42-92dc23241980_p1"> <start x="16143.75" y="5077.0"/> <end x="16186.645" y="5130.0"/> </arc> <arc class="production" id="prod_b1d08e53-0706-41f6-a060-2c33d084afde" source="pr_cda32f18-7c46-4147-9c42-92dc23241980_p2" target="wca1_s_wca4_s41_wca1_wca4_sa31"> <start x="16186.645" y="5160.0"/> <end x="16229.538" y="5213.0"/> </arc> <arc class="consumption" id="cons_30886576-969c-4e73-9b16-81bdf5828c03" source="wca1_s_wca4_s33_wca1_wca4_csa6" target="pr_b570fb1a-47e4-4f7c-a324-97a7a58f55b0_p1"> <start x="16238.0" y="5075.0"/> <end x="16238.451" y="5129.0"/> </arc> <arc class="production" id="prod_4ebffd4e-87f1-4265-a614-3b1f0b575f31" source="pr_b570fb1a-47e4-4f7c-a324-97a7a58f55b0_p2" target="wca1_s_wca4_s41_wca1_wca4_sa31"> <start x="16238.451" y="5159.0"/> <end x="16238.902" y="5213.0"/> </arc> <arc class="consumption" id="cons_18712532-a1d6-416c-9c5f-e5f313ead9a1" source="wca1_s_wca4_s26_wca1_wca4_csa5" target="pr_8659e415-3b9c-4cd5-bc77-4352ce385619_p1"> <start x="16238.0" y="5169.0"/> <end x="16238.373" y="5176.0"/> </arc> <arc class="production" id="prod_cabff388-6e72-4c14-8212-30027e636ec8" source="pr_8659e415-3b9c-4cd5-bc77-4352ce385619_p2" target="wca1_s_wca4_s41_wca1_wca4_sa31"> <start x="16238.373" y="5206.0"/> <end x="16238.746" y="5213.0"/> </arc> <arc class="consumption" id="cons_336dff69-5ef9-4b67-a141-f2a6be049e68" source="wca1_s_wca4_s42_wca1_wca4_sa32" target="pr_6e23d096-f3e8-4731-9d9d-a896ea3d4557_p1"> <start x="15938.0" y="3723.0"/> <end x="15952.0" y="3723.0"/> </arc> <arc class="production" id="prod_66cf682c-b9f2-48fa-a325-94586257e55b" source="pr_6e23d096-f3e8-4731-9d9d-a896ea3d4557_p2" target="wca1_s_wca4_s43_wca1_wca4_sa33"> <start x="15982.0" y="3723.0"/> <end x="15996.0" y="3723.0"/> </arc> <arc class="consumption" id="cons_e2002508-ee0c-4d2e-96e6-d1a395a13c9e" source="wca1_s_wca4_s44_wca1_wca4_sa34" target="pr_28649d46-84a7-4aad-9d0f-c3ef1755dc0c_p1"> <start x="15938.0" y="3771.0"/> <end x="15952.0" y="3771.0"/> </arc> <arc class="production" id="prod_e877fcf0-e16a-45c0-a344-fc2451391bf0" source="pr_28649d46-84a7-4aad-9d0f-c3ef1755dc0c_p2" target="wca1_s_wca4_s45_wca1_wca4_sa35"> <start x="15982.0" y="3771.0"/> <end x="15996.0" y="3771.0"/> </arc> <arc class="consumption" id="cons_0b5b1a9d-db3b-4923-8fa6-44c192d5376a" source="wca1_s_wca4_s43_wca1_wca4_sa33" target="pr_11eb87da-6558-4485-b87a-350b2bd45d18_p1"> <start x="16073.5" y="3723.0"/> <next x="16121.0" y="3749.5"/> <end x="16126.5" y="3749.5"/> </arc> <arc class="consumption" id="cons_cb4ccabd-01a7-4ed0-b54a-ca11cbaa883a" source="wca1_s_wca4_s45_wca1_wca4_sa35" target="pr_11eb87da-6558-4485-b87a-350b2bd45d18_p1"> <start x="16073.5" y="3771.0"/> <next x="16121.0" y="3749.5"/> <end x="16126.5" y="3749.5"/> </arc> <arc class="production" id="prod_859904de-5fef-4236-b225-6180a1d67c92" source="pr_11eb87da-6558-4485-b87a-350b2bd45d18_p2" target="wca1_s_wca4_s46_wca1_wca4_csa8"> <start x="16156.5" y="3749.5"/> <end x="16158.0" y="3749.5"/> </arc> <arc class="consumption" id="cons_84a74f17-d127-4bbc-8989-9890286ae8c0" source="wca1_s_wca4_s49_wca1_wca4_sa38" target="pr_289d44cc-8adb-4359-be05-1ca40be40a69_p1"> <start x="15938.0" y="3814.0"/> <end x="15952.0" y="3814.0"/> </arc> <arc class="production" id="prod_522b066e-61ff-4e87-9b14-c63a63efb0a2" source="pr_289d44cc-8adb-4359-be05-1ca40be40a69_p2" target="wca1_s_wca4_s50_wca1_wca4_sa39"> <start x="15982.0" y="3814.0"/> <end x="15996.0" y="3814.0"/> </arc> <arc class="consumption" id="cons_83ee1870-1fc8-41f9-9cd2-72ef3c96875c" source="wca1_s_wca4_s51_wca1_wca4_sa40" target="pr_4c9ffea4-e486-4a24-ac7e-1966d1122756_p1"> <start x="15938.0" y="3854.0"/> <end x="15952.0" y="3854.0"/> </arc> <arc class="production" id="prod_f41509e1-77da-43cd-9a2f-3a92cd5bb501" source="pr_4c9ffea4-e486-4a24-ac7e-1966d1122756_p2" target="wca1_s_wca4_s52_wca1_wca4_sa41"> <start x="15982.0" y="3854.0"/> <end x="15996.0" y="3854.0"/> </arc> <arc class="consumption" id="cons_46cfa8e5-b4b3-48b6-a8ee-51d67507538e" source="wca1_s_wca4_s50_wca1_wca4_sa39" target="pr_75cb8072-ff4f-4306-bdf0-c1e17f54fe83_p1"> <start x="16073.5" y="3814.0"/> <next x="16121.5" y="3845.5"/> <end x="16127.25" y="3845.5"/> </arc> <arc class="consumption" id="cons_ac487727-f39a-45fa-b03c-a384f734f0d0" source="wca1_s_wca4_s52_wca1_wca4_sa41" target="pr_75cb8072-ff4f-4306-bdf0-c1e17f54fe83_p1"> <start x="16073.5" y="3854.0"/> <next x="16121.5" y="3845.5"/> <end x="16127.25" y="3845.5"/> </arc> <arc class="production" id="prod_cb13b531-611a-417e-8e53-62b5395f3840" source="pr_75cb8072-ff4f-4306-bdf0-c1e17f54fe83_p2" target="wca1_s_wca4_s53_wca1_wca4_csa9"> <start x="16157.25" y="3845.5"/> <end x="16159.0" y="3845.5"/> </arc> <arc class="consumption" id="cons_c1555a68-838d-4ac0-8817-0fb5e3bdcd66" source="wca1_s_wca4_s56_wca1_wca4_sa44" target="pr_810ce438-4ade-435b-82af-39c80d39e4db_p1"> <start x="15938.0" y="3913.0"/> <end x="15952.0" y="3913.0"/> </arc> <arc class="production" id="prod_1369e212-830f-4a12-a355-182f84cb80f3" source="pr_810ce438-4ade-435b-82af-39c80d39e4db_p2" target="wca1_s_wca4_s57_wca1_wca4_sa45"> <start x="15982.0" y="3913.0"/> <end x="15996.0" y="3913.0"/> </arc> <arc class="consumption" id="cons_7ad91f3a-345f-429c-8d1e-ab046a172f39" source="wca1_s_wca4_s58_wca1_wca4_sa46" target="pr_cd23b71a-7ba5-4efb-9f9e-e6b761a542d1_p1"> <start x="15938.0" y="3952.0"/> <end x="15952.0" y="3952.0"/> </arc> <arc class="production" id="prod_2b300f0c-1881-41cd-a3e0-b2fac611f46f" source="pr_cd23b71a-7ba5-4efb-9f9e-e6b761a542d1_p2" target="wca1_s_wca4_s59_wca1_wca4_sa47"> <start x="15982.0" y="3952.0"/> <end x="15996.0" y="3952.0"/> </arc> <arc class="consumption" id="cons_75b893f7-6417-48ea-b57c-d2b43e4f5337" source="wca1_s_wca4_s57_wca1_wca4_sa45" target="pr_caa31c37-5fe7-48bc-a824-d3c1e00a952d_p1"> <start x="16073.5" y="3913.0"/> <next x="16121.5" y="3938.5"/> <end x="16127.25" y="3938.5"/> </arc> <arc class="consumption" id="cons_edff8bd8-48d7-46fd-8529-988dfdd615f6" source="wca1_s_wca4_s59_wca1_wca4_sa47" target="pr_caa31c37-5fe7-48bc-a824-d3c1e00a952d_p1"> <start x="16073.5" y="3952.0"/> <next x="16121.5" y="3938.5"/> <end x="16127.25" y="3938.5"/> </arc> <arc class="production" id="prod_b0e30f7c-1f68-43de-af86-b55bfab1dd1e" source="pr_caa31c37-5fe7-48bc-a824-d3c1e00a952d_p2" target="wca1_s_wca4_s60_wca1_wca4_csa10"> <start x="16157.25" y="3938.5"/> <end x="16159.0" y="3938.5"/> </arc> <arc class="consumption" id="cons_1716bfd8-016a-43ba-a60a-3ba4c60449c7" source="wca1_s_wca4_s63_wca1_wca4_sa50" target="pr_fa5b16db-863d-420f-90e1-dbf9c14f9bc1_p1"> <start x="15938.0" y="4011.0"/> <end x="15952.0" y="4011.0"/> </arc> <arc class="production" id="prod_dd3d681a-6ea3-42c6-9249-c77790c8b94e" source="pr_fa5b16db-863d-420f-90e1-dbf9c14f9bc1_p2" target="wca1_s_wca4_s64_wca1_wca4_sa51"> <start x="15982.0" y="4011.0"/> <end x="15996.0" y="4011.0"/> </arc> <arc class="consumption" id="cons_8005708f-b9c1-49fb-8340-b4ad524fb3cb" source="wca1_s_wca4_s65_wca1_wca4_sa52" target="pr_10243df0-e7cd-4e2e-823b-28a7802676d6_p1"> <start x="15938.0" y="4050.0"/> <end x="15952.0" y="4050.0"/> </arc> <arc class="production" id="prod_0cbaec37-b375-4334-943b-8dcd5f9869d8" source="pr_10243df0-e7cd-4e2e-823b-28a7802676d6_p2" target="wca1_s_wca4_s66_wca1_wca4_sa53"> <start x="15982.0" y="4050.0"/> <end x="15996.0" y="4050.0"/> </arc> <arc class="consumption" id="cons_d5261e58-35f7-4fec-9f10-44969845fa89" source="wca1_s_wca4_s64_wca1_wca4_sa51" target="pr_68776cb0-90c7-4b99-8e41-db1b841cc93f_p1"> <start x="16073.5" y="4011.0"/> <next x="16123.0" y="4035.0"/> <end x="16129.5" y="4035.0"/> </arc> <arc class="consumption" id="cons_4b40bcb1-0221-4104-863b-95158713785c" source="wca1_s_wca4_s66_wca1_wca4_sa53" target="pr_68776cb0-90c7-4b99-8e41-db1b841cc93f_p1"> <start x="16073.5" y="4050.0"/> <next x="16123.0" y="4035.0"/> <end x="16129.5" y="4035.0"/> </arc> <arc class="production" id="prod_22499b1f-ddd2-41f6-a246-c0f3870f2c7a" source="pr_68776cb0-90c7-4b99-8e41-db1b841cc93f_p2" target="wca1_s_wca4_s67_wca1_wca4_csa11"> <start x="16159.5" y="4035.0"/> <end x="16162.0" y="4035.0"/> </arc> <arc class="consumption" id="cons_92d86fa4-275a-41e1-8644-a97684ed6153" source="wca1_s_wca4_s46_wca1_wca4_csa8" target="pr_1d533c75-dc8d-4bf8-b605-ca6c5dca2c59_p1"> <start x="16258.0" y="3749.5"/> <end x="16299.354" y="3801.25"/> </arc> <arc class="production" id="prod_c22e5309-a54b-4c0c-b133-e1a8ddc4959a" source="pr_1d533c75-dc8d-4bf8-b605-ca6c5dca2c59_p2" target="wca1_s_wca4_s41_wca1_wca4_sa56"> <start x="16299.354" y="3831.25"/> <end x="16340.707" y="3883.0"/> </arc> <arc class="consumption" id="cons_6307bfe2-d461-485c-8b6d-8a59b7d05b0a" source="wca1_s_wca4_s53_wca1_wca4_csa9" target="pr_794bf603-f11b-49c4-b550-e344638daffa_p1"> <start x="16258.0" y="3845.5"/> <end x="16281.5" y="3867.4702"/> </arc> <arc class="production" id="prod_595eb0ef-2bef-4759-b5f9-9987946d74c4" source="pr_794bf603-f11b-49c4-b550-e344638daffa_p2" target="wca1_s_wca4_s41_wca1_wca4_sa56"> <start x="16311.5" y="3867.4702"/> <end x="16335.0" y="3889.4402"/> </arc> <arc class="consumption" id="cons_33511bc9-1722-4d09-8a36-f4cc9a49be45" source="wca1_s_wca4_s60_wca1_wca4_csa10" target="pr_eb518e12-6e0c-4ea1-8bfe-f43a461f306e_p1"> <start x="16259.0" y="3938.5"/> <end x="16282.0" y="3921.588"/> </arc> <arc class="production" id="prod_44e02573-bd55-4343-b63d-c4a1f8481d7c" source="pr_eb518e12-6e0c-4ea1-8bfe-f43a461f306e_p2" target="wca1_s_wca4_s41_wca1_wca4_sa56"> <start x="16312.0" y="3921.588"/> <end x="16335.0" y="3904.6758"/> </arc> <arc class="consumption" id="cons_142d16e8-440c-49e8-8be9-a905d64e3ca4" source="wca1_s_wca4_s67_wca1_wca4_csa11" target="pr_60d09990-44eb-4527-b489-89a13a581d73_p1"> <start x="16258.0" y="4035.0"/> <end x="16298.963" y="3989.0"/> </arc> <arc class="production" id="prod_53185806-460e-4c78-b3e6-6dda86118e8a" source="pr_60d09990-44eb-4527-b489-89a13a581d73_p2" target="wca1_s_wca4_s41_wca1_wca4_sa56"> <start x="16298.963" y="3959.0"/> <end x="16339.927" y="3913.0"/> </arc> <arc class="consumption" id="cons_8f70ddea-7244-4bd7-948b-be3ea8fe59f2" source="wca1_s_wca4_s70_wca1_wca4_sa57" target="pr_5710862c-357f-485a-95a3-ce86bac63554_p1"> <start x="15806.0" y="4128.0"/> <end x="15815.0" y="4128.0"/> </arc> <arc class="production" id="prod_9bf41d58-064a-458c-8910-80bb86cd23e1" source="pr_5710862c-357f-485a-95a3-ce86bac63554_p2" target="wca1_s_wca4_s71_wca1_wca4_sa58"> <start x="15845.0" y="4128.0"/> <end x="15854.0" y="4128.0"/> </arc> <arc class="consumption" id="cons_2a043f9d-1f04-458c-93e6-c5bf074e35b5" source="wca1_s_wca4_s71_wca1_wca4_sa58" target="pr_6c497478-2338-429a-a517-a843b539df57_p1"> <start x="15944.0" y="4128.0"/> <end x="15956.5" y="4128.0"/> </arc> <arc class="production" id="prod_67a0c0b9-5893-462d-a08b-a84014213370" source="pr_6c497478-2338-429a-a517-a843b539df57_p2" target="wca1_s_wca4_s72_wca1_wca4_sa59"> <start x="15986.5" y="4128.0"/> <end x="15999.0" y="4128.0"/> </arc> <arc class="catalysis" id="modif_45934fd6-5e01-491b-aa6b-9bf0d106f6ac" source="wca1_s_wca4_s73_wca1_wca4_sa60" target="pr_6c497478-2338-429a-a517-a843b539df57"> <start x="15966.0" y="4195.0"/> <end x="15971.5" y="4133.0"/> </arc> <arc class="consumption" id="cons_85445afb-b06d-4ff0-a174-78d475b5db9d" source="wca1_s_wca4_s72_wca1_wca4_sa59" target="pr_ccaf5231-f099-4c0f-8954-39dc837bfb96_p1"> <start x="16079.0" y="4128.0"/> <next x="16096.0" y="4172.0"/> <end x="16115.5" y="4172.0"/> </arc> <arc class="consumption" id="cons_70bb2c0b-0e4f-4434-9471-bb738a805b4d" source="wca1_s_wca4_s73_wca1_wca4_sa60" target="pr_ccaf5231-f099-4c0f-8954-39dc837bfb96_p1"> <start x="16006.0" y="4215.0"/> <next x="16096.0" y="4172.0"/> <end x="16115.5" y="4172.0"/> </arc> <arc class="production" id="prod_308875ad-c5b4-4018-96bd-1a4c5638899b" source="pr_ccaf5231-f099-4c0f-8954-39dc837bfb96_p2" target="wca1_s_wca4_s74_wca1_wca4_csa12"> <start x="16145.5" y="4172.0"/> <end x="16161.0" y="4172.0"/> </arc> <arc class="stimulation" id="direct_fa44c9f6-b50f-46c3-8bd9-67a4495ac00c" source="wca1_s_wca4_s74_wca1_wca4_csa12" target="wca1_s_wca4_s77_wca1_wca4_sa65"> <start x="16261.0" y="4172.0"/> <end x="16341.0" y="4172.6665"/> </arc> <arc class="consumption" id="cons_4db66fc2-ff58-43c5-a9ca-3e3386b1ca08" source="wca1_s_wca4_s78_wca1_wca4_sa66" target="pr_f4ff347c-a7c0-4489-b3a8-d4d5ee91b443_p1"> <start x="15747.0" y="4303.0"/> <end x="15761.75" y="4303.0"/> </arc> <arc class="production" id="prod_335076dd-bd49-42c7-9e05-94338fa822db" source="pr_f4ff347c-a7c0-4489-b3a8-d4d5ee91b443_p2" target="wca1_s_wca4_s79_wca1_wca4_sa67"> <start x="15791.75" y="4303.0"/> <end x="15806.5" y="4303.0"/> </arc> <arc class="catalysis" id="modif_d3553b0d-c310-439d-a493-8001115bbc06" source="wca1_s_wca4_s82_wca1_wca4_sa70" target="pr_f4ff347c-a7c0-4489-b3a8-d4d5ee91b443"> <start x="16149.0" y="4360.3726"/> <end x="15776.75" y="4308.0"/> </arc> <arc class="inhibition" id="modif_de8749d8-b680-4666-8474-2b0bef803ecd" source="wca1_s_wca4_s83_wca1_wca4_sa71" target="pr_f4ff347c-a7c0-4489-b3a8-d4d5ee91b443"> <start x="16149.0" y="4404.618"/> <end x="15776.75" y="4308.0"/> </arc> <arc class="inhibition" id="modif_db0a604b-4bb0-419a-bb5d-3149188cc4ab" source="wca1_s_wca4_s84_wca1_wca4_sa72" target="pr_f4ff347c-a7c0-4489-b3a8-d4d5ee91b443"> <start x="16149.136" y="4450.0"/> <end x="15771.75" y="4308.0"/> </arc> <arc class="consumption" id="cons_efdf6f3a-a0cc-43e2-80a8-28ff45eab594" source="wca1_s_wca4_s79_wca1_wca4_sa67" target="pr_59e8b15d-3af3-468c-b5d1-edd8fa492f48_p1"> <start x="15896.5" y="4303.0"/> <end x="15911.25" y="4303.0"/> </arc> <arc class="production" id="prod_8f888d4e-3744-4bde-ac42-611ebdfc0984" source="pr_59e8b15d-3af3-468c-b5d1-edd8fa492f48_p2" target="wca1_s_wca4_s80_wca1_wca4_sa68"> <start x="15941.25" y="4303.0"/> <end x="15956.0" y="4303.0"/> </arc> <arc class="stimulation" id="direct_21a12fff-8ce8-4a03-bcbf-914ea52ce508" source="wca1_s_wca4_s80_wca1_wca4_sa68" target="wca1_s_wca4_s81_wca1_wca4_sa69"> <start x="16036.0" y="4303.0"/> <end x="16149.0" y="4302.261"/> </arc> <arc class="consumption" id="cons_2d1aaab1-40af-4df7-bea4-1332dabde148" source="wca1_s_wca4_s85_wca1_wca4_sa73" target="pr_8d7206f5-407c-4ffc-af61-7c9285f9528c_p1"> <start x="16105.0" y="3597.0"/> <end x="16129.5" y="3580.5"/> </arc> <arc class="production" id="prod_9723d67e-6a0c-4307-99cf-6eba8f267181" source="pr_8d7206f5-407c-4ffc-af61-7c9285f9528c_p2" target="wca1_s_wca4_s86_wca1_wca4_sa74"> <start x="16129.5" y="3550.5"/> <end x="16154.0" y="3534.0"/> </arc> <arc class="consumption" id="cons_469beee2-a2fc-4389-97c2-04f31136857b" source="wca1_s_wca4_s21_wca1_wca4_sa14" target="pr_8d46b514-aac9-4ef1-b3ff-02c031608a74_p1"> <start x="16086.0" y="3674.8633"/> <end x="16110.5" y="3674.4316"/> </arc> <arc class="production" id="prod_11f8ba6f-e168-4198-87e4-28f4beafc630" source="pr_8d46b514-aac9-4ef1-b3ff-02c031608a74_p2" target="wca1_s_wca4_s87_wca1_wca4_sa75"> <start x="16140.5" y="3674.4316"/> <end x="16165.0" y="3674.0"/> </arc> <arc class="inhibition" id="modif_7bda60bb-c6c0-46bb-bef5-a2b9031a8881" source="wca1_s_wca4_s21_wca1_wca4_sa14" target="pr_8d46b514-aac9-4ef1-b3ff-02c031608a74"> <start x="16053.5" y="3662.5"/> <next x="16053.254" y="3644.4648"/> <next x="16125.091" y="3643.4832"/> <end x="16125.445" y="3669.432"/> </arc> <arc class="consumption" id="cons_0e91ad72-837d-49ac-a05c-744fdfbdd0de" source="wca1_s_wca4_s88_wca1_wca4_sa76" target="pr_e961f312-8802-4c2b-b51a-328526a68c7a_p1"> <start x="15747.0" y="4352.75"/> <end x="15761.75" y="4352.75"/> </arc> <arc class="production" id="prod_fbe634c4-5b15-4499-869d-464f2a17983b" source="pr_e961f312-8802-4c2b-b51a-328526a68c7a_p2" target="wca1_s_wca4_s89_wca1_wca4_sa77"> <start x="15791.75" y="4352.75"/> <end x="15806.5" y="4352.75"/> </arc> <arc class="inhibition" id="modif_2462d39d-f4ec-42b0-a461-9347464c07bd" source="wca1_s_wca4_s91_wca1_wca4_sa79" target="pr_e961f312-8802-4c2b-b51a-328526a68c7a"> <start x="15822.0" y="4251.0"/> <end x="15776.75" y="4347.75"/> </arc> <arc class="consumption" id="cons_44c75519-5d03-484a-951a-db747149cb34" source="wca1_s_wca4_s89_wca1_wca4_sa77" target="pr_0c822aab-e049-4242-b2f7-d9ea8e8ff82d_p1"> <start x="15896.5" y="4352.75"/> <end x="15911.25" y="4352.75"/> </arc> <arc class="production" id="prod_86fed786-ad4f-427e-893b-ef1082c61e2d" source="pr_0c822aab-e049-4242-b2f7-d9ea8e8ff82d_p2" target="wca1_s_wca4_s90_wca1_wca4_sa78"> <start x="15941.25" y="4352.75"/> <end x="15956.0" y="4352.75"/> </arc> <arc class="inhibition" id="direct_2696b8da-7956-4769-86f0-669c050334a9" source="wca1_s_wca4_s90_wca1_wca4_sa78" target="wca1_s_wca4_s81_wca1_wca4_sa69"> <start x="16036.0" y="4352.75"/> <end x="16149.0" y="4315.268"/> </arc> <arc class="stimulation" id="direct_8578c2b2-f9e1-4539-8249-f54bae91a49b" source="wca1_s_wca4_s91_wca1_wca4_sa79" target="wca1_s_wca4_s83_wca1_wca4_sa71"> <start x="15862.0" y="4231.0"/> <end x="16162.343" y="4400.0"/> </arc> <arc class="consumption" id="cons_7cadd2e1-8cf5-4439-a0e2-bfccabe2bad6" source="shh1_s_shh1_s413_shh1_shh1_sa65" target="pr_a86ace11-07af-483f-8b99-d77eefb5d1ce_p1"> <start x="18168.75" y="1660.0538"/> <end x="18105.375" y="1803.0269"/> </arc> <arc class="production" id="prod_c230e837-3ccd-477b-b080-3903730ed7e9" source="pr_a86ace11-07af-483f-8b99-d77eefb5d1ce_p2" target="shh1_s_shh1_s153_shh1_shh1_sa67"> <start x="18105.375" y="1833.0269"/> <end x="18042.0" y="1976.0"/> </arc> <arc class="consumption" id="cons_a2c1633d-cc8a-4457-b251-1448044f4a12" source="shh1_s_shh1_s470_shh1_shh1_sa123" target="pr_67d02ef9-15cd-4005-8561-7b6c49e7c238_p1"> <start x="18397.574" y="1659.7703"/> <end x="18434.287" y="1802.8851"/> </arc> <arc class="production" id="prod_a9a850b3-9790-4370-aae5-8d72d170314c" source="pr_67d02ef9-15cd-4005-8561-7b6c49e7c238_p2" target="shh1_s_shh1_s158_shh1_shh1_sa69"> <start x="18434.287" y="1832.8851"/> <end x="18471.0" y="1976.0"/> </arc> <arc class="catalysis" id="modif_f50cddfa-9605-4c2c-b091-85439515c59a" source="shh1_s_shh1_s470_shh1_shh1_sa123" target="pr_67d02ef9-15cd-4005-8561-7b6c49e7c238"> <start x="18480.074" y="1639.2703"/> <next x="18505.574" y="1639.2715"/> <next x="18505.57" y="1737.655"/> <next x="18439.162" y="1737.6519"/> <end x="18439.158" y="1816.7543"/> </arc> <arc class="consumption" id="cons_7253b4e4-765e-4d2b-8cb5-b6b017351895" source="shh1_s_shh1_s2_shh1_shh1_sa2" target="pr_e328af47-7edc-420f-b568-4f82a72c0a77_p1"> <start x="19576.0" y="64.0"/> <next x="19231.83" y="181.59889"/> <end x="19228.414" y="181.82388"/> </arc> <arc class="consumption" id="cons_327c6443-0722-4ffe-b516-d0a92b431c6c" source="shh1_s_shh1_s1_shh1_shh1_sa1" target="pr_e328af47-7edc-420f-b568-4f82a72c0a77_p1"> <start x="19256.0" y="183.4"/> <next x="19231.83" y="181.59889"/> <end x="19228.414" y="181.82388"/> </arc> <arc class="production" id="prod_a3b85db9-bf02-495b-9a70-e1472f3e85fe" source="pr_e328af47-7edc-420f-b568-4f82a72c0a77_p2" target="shh1_s_shh1_s260_shh1_shh1_csa14"> <start x="19198.414" y="181.82388"/> <end x="19199.0" y="182.0"/> </arc> <arc class="consumption" id="cons_9f2ed4ae-69f4-4e39-8414-7a4d06ddcba2" source="shh1_s_shh1_s260_shh1_shh1_csa14" target="pr_d161d8a4-31d5-41d8-afc1-f4b1a735a370_p1"> <start x="19082.0" y="182.0"/> <end x="18953.25" y="177.5"/> </arc> <arc class="production" id="prod_b4c2ed75-d2e8-4de8-8459-35b8e9ec7310" source="pr_d161d8a4-31d5-41d8-afc1-f4b1a735a370_p2" target="shh1_s635_shh1_shh1_csa15"> <start x="18923.25" y="177.5"/> <end x="18794.5" y="173.0"/> </arc> <arc class="inhibition" id="modif_448f5284-f827-4e01-bdcc-44c188ff1fb7" source="shh1_s_shh1_s605_shh1_shh1_csa55" target="pr_d161d8a4-31d5-41d8-afc1-f4b1a735a370"> <start x="19846.5" y="597.0"/> <end x="18938.094" y="182.49756"/> </arc> <arc class="consumption" id="cons_98ed833a-8dcd-4170-9e6c-2fb6b99676c9" source="shh1_s635_shh1_shh1_csa15" target="pr_971ebf0c-bf1a-4d5b-9a65-1613bc294af6_p1"> <start x="18677.5" y="212.75"/> <next x="18599.615" y="299.80316"/> <end x="18576.184" y="299.77512"/> </arc> <arc class="consumption" id="cons_a698aa20-ec52-4014-afd7-c986d8e5f2f1" source="shh1_s_shh1_s581_shh1_shh1_csa59" target="pr_971ebf0c-bf1a-4d5b-9a65-1613bc294af6_p1"> <start x="18598.5" y="276.0"/> <next x="18599.615" y="299.80316"/> <end x="18576.184" y="299.77512"/> </arc> <arc class="production" id="prod_cf740a59-58a8-4a1e-a0d4-8bb489da384c" source="pr_971ebf0c-bf1a-4d5b-9a65-1613bc294af6_p2" target="shh1_s656_shh1_shh1_csa16"> <start x="18546.184" y="299.77512"/> <end x="18526.75" y="299.75"/> </arc> <arc class="consumption" id="addreact_30072477-a6b9-47a7-ad35-e6cac73ec24f" source="shh1_s_shh1_s583_shh1_shh1_sa338" target="pr_971ebf0c-bf1a-4d5b-9a65-1613bc294af6_p1"> <start x="18617.0" y="334.7726"/> <end x="18576.184" y="299.77512"/> </arc> <arc class="production" id="addprod_3a2279f6-633f-408d-b293-3d269c20e5c9" source="pr_971ebf0c-bf1a-4d5b-9a65-1613bc294af6_p2" target="shh1_s_shh1_s584_shh1_shh1_sa339"> <start x="18546.184" y="299.77512"/> <end x="18555.215" y="348.0"/> </arc> <arc class="consumption" id="cons_ae3fcf3f-37f5-4bee-9a71-fcc9297f10e4" source="shh1_s656_shh1_shh1_csa16" target="pr_3c41b30a-558b-43f3-91e8-89f9f4765756_p1"> <start x="18400.75" y="229.5"/> <end x="18403.375" y="230.14566"/> </arc> <arc class="production" id="prod_90df248c-f9f8-4601-905a-abe9906ac8b3" source="pr_3c41b30a-558b-43f3-91e8-89f9f4765756_p2" target="shh1_s635_shh1_shh1_csa17"> <start x="18373.375" y="230.14566"/> <next x="18376.0" y="230.7913"/> <end x="18360.875" y="180.0"/> </arc> <arc class="production" id="prod_abb05005-526a-4360-a08c-aabf38b31111" source="pr_3c41b30a-558b-43f3-91e8-89f9f4765756_p2" target="shh1_s_shh1_s283_shh1_shh1_sa142"> <start x="18373.375" y="230.14566"/> <next x="18376.0" y="230.7913"/> <end x="18518.625" y="425.5"/> </arc> <arc class="production" id="addprod_ea0a6cde-a15e-4041-8f91-df8bed2c55f6" source="pr_3c41b30a-558b-43f3-91e8-89f9f4765756_p2" target="shh1_s_shh1_s589_shh1_shh1_csa60"> <start x="18373.375" y="230.14566"/> <end x="18243.0" y="287.0"/> </arc> <arc class="production" id="addprod_751556b8-f662-44b1-88d6-b17aa1c41aac" source="pr_3c41b30a-558b-43f3-91e8-89f9f4765756_p2" target="shh1_s_shh1_s593_shh1_shh1_csa61"> <start x="18373.375" y="230.14566"/> <end x="18333.0" y="299.0"/> </arc> <arc class="consumption" id="cons_0527b968-5c0c-4990-a16d-f40a0992a535" source="shh1_s_shh1_s283_shh1_shh1_sa142" target="pr_2d4ba223-641b-4290-b82b-31c6390f3edf_p1"> <start x="18558.625" y="445.5"/> <end x="18583.062" y="445.75"/> </arc> <arc class="production" id="prod_ca1fbddc-837a-41d5-96d4-c802fa0695b0" source="pr_2d4ba223-641b-4290-b82b-31c6390f3edf_p2" target="shh1_s_shh1_s284_shh1_shh1_sa143"> <start x="18613.062" y="445.75"/> <end x="18637.5" y="446.0"/> </arc> <arc class="catalysis" id="modif_aad94652-ad29-46c3-8a8f-70a6d31cc604" source="shh1_s_shh1_s596_shh1_shh1_csa62" target="pr_2d4ba223-641b-4290-b82b-31c6390f3edf"> <start x="18599.5" y="497.0"/> <end x="18598.031" y="450.7499"/> </arc> <arc class="consumption" id="cons_88aceeb5-3bbd-4ad2-9b16-9c42f2661786" source="shh1_s_shh1_s284_shh1_shh1_sa143" target="pr_0d8e354b-fe7b-4ced-b3d6-9903b0257b7a_p1"> <start x="18677.5" y="446.0"/> <next x="18775.883" y="327.59012"/> <end x="18804.441" y="326.49475"/> </arc> <arc class="consumption" id="cons_108239df-0a92-47bf-a022-fee61262eb1e" source="shh1_s_shh1_s287_shh1_shh1_sa146" target="pr_0d8e354b-fe7b-4ced-b3d6-9903b0257b7a_p1"> <start x="18712.75" y="297.25"/> <next x="18775.883" y="327.59012"/> <end x="18804.441" y="326.49475"/> </arc> <arc class="production" id="prod_b2e285a7-42fe-4132-a842-fbca24768b04" source="pr_0d8e354b-fe7b-4ced-b3d6-9903b0257b7a_p2" target="shh1_s_shh1_s291_shh1_shh1_csa18"> <start x="18834.441" y="326.49475"/> <end x="18859.0" y="325.5"/> </arc> <arc class="consumption" id="addreact_9be76a1a-0065-440b-9e0f-44e34e931709" source="shh1_s_shh1_s541_shh1_shh1_csa51" target="pr_0d8e354b-fe7b-4ced-b3d6-9903b0257b7a_p1"> <start x="18646.0" y="686.0"/> <end x="18804.441" y="326.49475"/> </arc> <arc class="consumption" id="cons_79c53f37-7881-4ee0-a9bd-c66b5cd89dbf" source="shh1_s_shh1_s296_shh1_shh1_csa19" target="pr_7649fe89-c6c0-4b84-a85b-0d3aa6d5191b_p1"> <start x="19318.0" y="546.0"/> <end x="19331.074" y="541.375"/> </arc> <arc class="production" id="prod_bf6669ee-040d-4fed-be79-463fe6df1d72" source="pr_7649fe89-c6c0-4b84-a85b-0d3aa6d5191b_p2" target="shh1_s_shh1_s300_shh1_shh1_sa157"> <start x="19331.074" y="511.375"/> <next x="19344.148" y="506.75"/> <end x="19373.125" y="509.0"/> </arc> <arc class="production" id="prod_9bf8b4ea-3309-4b66-a039-8f8200bce8ad" source="pr_7649fe89-c6c0-4b84-a85b-0d3aa6d5191b_p2" target="shh1_s_shh1_s302_shh1_shh1_sa3"> <start x="19331.074" y="511.375"/> <next x="19344.148" y="506.75"/> <end x="19803.71" y="190.75"/> </arc> <arc class="production" id="addprod_cad8a420-bbfe-4537-971d-46391cd40ede" source="pr_7649fe89-c6c0-4b84-a85b-0d3aa6d5191b_p2" target="shh1_s_shh1_s545_shh1_shh1_csa52"> <start x="19331.074" y="511.375"/> <end x="19361.0" y="563.0"/> </arc> <arc class="consumption" id="cons_8f769559-b397-4d0f-a6d4-72b508376d0a" source="shh1_s_shh1_s291_shh1_shh1_csa18" target="pr_83f6a107-4df1-4c17-a8bc-3cd60d7754f6_p1"> <start x="18970.0" y="325.5"/> <end x="19071.5" y="435.75"/> </arc> <arc class="production" id="prod_987436a7-f41f-48c2-9e15-d02ebe3653b1" source="pr_83f6a107-4df1-4c17-a8bc-3cd60d7754f6_p2" target="shh1_s_shh1_s296_shh1_shh1_csa19"> <start x="19101.5" y="435.75"/> <end x="19203.0" y="546.0"/> </arc> <arc class="modulation" id="modif_b4a221e1-8f9a-4c63-887b-a8dabc2bb80c" source="shh1_s_shh1_s566_shh1_shh1_sa327" target="pr_83f6a107-4df1-4c17-a8bc-3cd60d7754f6"> <start x="19036.0" y="511.0"/> <end x="19083.062" y="439.3816"/> </arc> <arc class="consumption" id="cons_ca785cf7-4ed3-4453-ac27-b5b33c1fe45a" source="shh1_s_shh2_s131_shh1_shh1_sa128" target="pr_eff265b1-555d-4385-8ce0-6907ed6f4c41_p1"> <start x="18036.0" y="486.0"/> <next x="18109.25" y="474.0"/> <end x="18145.625" y="471.919"/> </arc> <arc class="consumption" id="cons_9c4c7717-5436-4d06-83c8-edfaf9c31377" source="shh1_s_shh1_s259_shh1_shh1_sa130" target="pr_eff265b1-555d-4385-8ce0-6907ed6f4c41_p1"> <start x="18087.5" y="653.5"/> <next x="18109.25" y="474.0"/> <end x="18145.625" y="471.919"/> </arc> <arc class="production" id="prod_e216ff10-e412-494c-8e16-11c983df582b" source="pr_eff265b1-555d-4385-8ce0-6907ed6f4c41_p2" target="shh1_s_shh1_s303_shh1_shh1_csa20"> <start x="18175.625" y="471.919"/> <end x="18208.0" y="470.0"/> </arc> <arc class="consumption" id="addreact_24787750-dd0c-43d2-aa68-e466fa531f19" source="shh1_s_shh1_s577_shh1_shh1_sa174" target="pr_eff265b1-555d-4385-8ce0-6907ed6f4c41_p1"> <start x="18057.906" y="362.0"/> <end x="18145.625" y="471.919"/> </arc> <arc class="consumption" id="addreact_da32b226-d9bf-4eae-9c63-4d770b76b2d4" source="shh1_s639_shh1_shh1_sa180" target="pr_eff265b1-555d-4385-8ce0-6907ed6f4c41_p1"> <start x="18148.484" y="362.0"/> <end x="18145.625" y="471.919"/> </arc> <arc class="consumption" id="cons_f0694970-180a-4792-95c4-89e63b2c5b9e" source="shh1_s_shh2_s131_shh1_shh1_sa128" target="pr_78bccc99-37f2-4909-bd33-bc2188450f7e_p1"> <start x="18036.0" y="486.0"/> <next x="18164.25" y="715.125"/> <end x="18191.137" y="694.5625"/> </arc> <arc class="consumption" id="cons_c5d0f9c9-01ab-4366-9237-be220298f67c" source="shh1_s638_shh1_shh1_sa147" target="pr_78bccc99-37f2-4909-bd33-bc2188450f7e_p1"> <start x="18087.5" y="787.5"/> <next x="18164.25" y="715.125"/> <end x="18191.137" y="694.5625"/> </arc> <arc class="production" id="prod_087a4310-6bc4-47ef-bfe3-6cd7f918fc10" source="pr_78bccc99-37f2-4909-bd33-bc2188450f7e_p2" target="shh1_s_shh1_s306_shh1_shh1_csa21"> <start x="18191.137" y="664.5625"/> <end x="18215.0" y="648.0"/> </arc> <arc class="consumption" id="addreact_489dc184-9214-455f-97d6-e3ce99a4e95e" source="shh1_s_shh1_s577_shh1_shh1_sa174" target="pr_78bccc99-37f2-4909-bd33-bc2188450f7e_p1"> <start x="18049.455" y="362.0"/> <end x="18191.137" y="694.5625"/> </arc> <arc class="consumption" id="addreact_a691053d-423f-420c-b07f-ec6c75dcd0a2" source="shh1_s639_shh1_shh1_sa180" target="pr_78bccc99-37f2-4909-bd33-bc2188450f7e_p1"> <start x="18148.0" y="362.0"/> <end x="18191.137" y="694.5625"/> </arc> <arc class="consumption" id="cons_c2016c43-816a-4e7a-b17b-23a7684ab024" source="shh1_s_shh1_s303_shh1_shh1_csa20" target="pr_28c3c282-e1cc-4c57-8e3a-ff48953bea6c_p1"> <start x="18418.0" y="470.0"/> <end x="18938.75" y="461.25"/> </arc> <arc class="production" id="prod_ff6cd19a-7b97-4a9e-b4da-abd3c473dc31" source="pr_28c3c282-e1cc-4c57-8e3a-ff48953bea6c_p2" target="shh1_s_shh1_s309_shh1_shh1_csa22"> <start x="18968.75" y="461.25"/> <end x="19489.5" y="452.5"/> </arc> <arc class="catalysis" id="modif_3b917e62-bcef-4093-9bde-6971cb1b0af3" source="shh1_s_shh1_s302_shh1_shh1_sa3" target="pr_28c3c282-e1cc-4c57-8e3a-ff48953bea6c"> <start x="19793.0" y="183.73717"/> <end x="18953.668" y="456.25067"/> </arc> <arc class="inhibition" id="modif_87af5fc5-743f-4e75-93c9-a4b10ade75aa" source="shh1_s_shh2_s38_shh1_shh1_sa167" target="pr_28c3c282-e1cc-4c57-8e3a-ff48953bea6c"> <start x="18932.78" y="546.0"/> <end x="18953.832" y="466.24933"/> </arc> <arc class="consumption" id="cons_d8d1a659-a9c3-40e9-83a2-da4c94ea344d" source="shh1_s_shh1_s306_shh1_shh1_csa21" target="pr_9670f83b-b04f-42bc-9dd3-f2efd97be439_p1"> <start x="18421.0" y="648.0"/> <end x="18943.25" y="647.5"/> </arc> <arc class="production" id="prod_be143183-cb29-40a0-9274-e6f09b0c4a7f" source="pr_9670f83b-b04f-42bc-9dd3-f2efd97be439_p2" target="shh1_s_shh1_s310_shh1_shh1_csa23"> <start x="18973.25" y="647.5"/> <end x="19495.5" y="647.0"/> </arc> <arc class="catalysis" id="modif_ec16b92b-b40b-4c4e-b74a-07c84f87e445" source="shh1_s_shh1_s302_shh1_shh1_sa3" target="pr_9670f83b-b04f-42bc-9dd3-f2efd97be439"> <start x="19796.127" y="190.75"/> <end x="18963.246" y="642.49536"/> </arc> <arc class="inhibition" id="modif_79f8def8-afbb-4d0e-9224-772118961b3c" source="shh1_s_shh2_s38_shh1_shh1_sa167" target="pr_9670f83b-b04f-42bc-9dd3-f2efd97be439"> <start x="18934.23" y="586.0"/> <end x="18953.246" y="642.50464"/> </arc> <arc class="consumption" id="cons_7918c78a-a3dc-4442-a396-6794c5827e67" source="shh1_s_shh1_s309_shh1_shh1_csa22" target="pr_29d712f1-20ea-4cb0-8567-03e14ac24281_p1"> <start x="19694.5" y="452.5"/> <end x="19742.688" y="407.18433"/> </arc> <arc class="production" id="prod_c89fe9cb-82f1-479e-addc-dd252b2ac8c9" source="pr_29d712f1-20ea-4cb0-8567-03e14ac24281_p2" target="shh1_s_shh1_s357_shh1_shh1_sa168"> <start x="19772.688" y="407.18433"/> <next x="19820.875" y="361.86865"/> <end x="19869.336" y="330.0"/> </arc> <arc class="production" id="prod_36cb3896-7814-4454-8f8b-60ba023c5148" source="pr_29d712f1-20ea-4cb0-8567-03e14ac24281_p2" target="shh1_s_shh1_s316_shh1_shh1_sa169"> <start x="19772.688" y="407.18433"/> <next x="19820.875" y="361.86865"/> <end x="19992.75" y="363.94742"/> </arc> <arc class="catalysis" id="logicarc_1adb9e8b-8373-48c4-adf1-1beccbbd23f7" source="logicglyph_7a4a2f04-220c-44e5-a4b7-6b4592db790b_p2" target="pr_29d712f1-20ea-4cb0-8567-03e14ac24281"> <start x="19623.473" y="260.70184"/> <end x="19754.773" y="403.1212"/> </arc> <arc class="logic arc" id="modif_b252fc27-fcc8-468f-9df8-0f334688e516" source="shh1_s_shh1_s302_shh1_shh1_sa3" target="logicglyph_7a4a2f04-220c-44e5-a4b7-6b4592db790b_p1"> <start x="19833.0" y="190.75"/> <end x="19623.473" y="220.70186"/> </arc> <arc class="logic arc" id="modif_d18fcfb1-d8fa-4728-9ef8-edf841742c01" source="shh1_s_shh1_s545_shh1_shh1_csa52" target="logicglyph_7a4a2f04-220c-44e5-a4b7-6b4592db790b_p1"> <start x="19442.69" y="563.0"/> <end x="19623.473" y="220.70186"/> </arc> <arc class="production" id="addprod_0a97481a-22d9-4110-b095-4ef906cd9a5a" source="pr_29d712f1-20ea-4cb0-8567-03e14ac24281_p2" target="shh1_s_shh1_s326_shh1_shh1_sa179"> <start x="19772.688" y="407.18433"/> <end x="19892.0" y="523.0"/> </arc> <arc class="production" id="addprod_30a7a4b8-c1d1-4172-9c80-5d516a26bf1f" source="pr_29d712f1-20ea-4cb0-8567-03e14ac24281_p2" target="shh1_s_shh1_s332_shh1_shh1_sa185"> <start x="19772.688" y="407.18433"/> <end x="19342.998" y="795.668"/> </arc> <arc class="consumption" id="cons_0585091c-20f0-486b-9c23-0f347999bbaf" source="shh1_s_shh1_s310_shh1_shh1_csa23" target="pr_92ec7fac-b93a-487b-a231-5da2f81c54cf_p1"> <start x="19701.5" y="647.0"/> <end x="19793.688" y="549.8134"/> </arc> <arc class="production" id="prod_b483d5b8-6d7c-4727-99c6-efa58888941f" source="pr_92ec7fac-b93a-487b-a231-5da2f81c54cf_p2" target="shh1_s_shh1_s357_shh1_shh1_sa168"> <start x="19823.688" y="549.8134"/> <next x="19915.875" y="452.6268"/> <end x="19902.86" y="330.0"/> </arc> <arc class="production" id="prod_4ec5b71c-b639-4851-9079-5a2f7d8488dd" source="pr_92ec7fac-b93a-487b-a231-5da2f81c54cf_p2" target="shh1_s_shh1_s318_shh1_shh1_sa171"> <start x="19823.688" y="549.8134"/> <next x="19915.875" y="452.6268"/> <end x="19992.75" y="458.14603"/> </arc> <arc class="catalysis" id="logicarc_8b96e7e0-921d-473b-bf02-30de3a2f19fa" source="logicglyph_b77300a0-9d75-4c81-b8cf-5fd209ac7acf_p2" target="pr_92ec7fac-b93a-487b-a231-5da2f81c54cf"> <start x="19623.441" y="348.90414"/> <end x="19805.328" y="546.1093"/> </arc> <arc class="logic arc" id="modif_faadae21-af1c-4604-b7dc-e95dfc8de8fc" source="shh1_s_shh1_s302_shh1_shh1_sa3" target="logicglyph_b77300a0-9d75-4c81-b8cf-5fd209ac7acf_p1"> <start x="19833.0" y="190.75"/> <end x="19623.441" y="308.90414"/> </arc> <arc class="logic arc" id="modif_df7e90c8-cb67-4635-94a8-85920da02d7a" source="shh1_s_shh1_s545_shh1_shh1_csa52" target="logicglyph_b77300a0-9d75-4c81-b8cf-5fd209ac7acf_p1"> <start x="19451.582" y="563.0"/> <end x="19623.441" y="308.90414"/> </arc> <arc class="production" id="addprod_bd9fbf11-a71c-4eac-9e7f-21cb21a105e3" source="pr_92ec7fac-b93a-487b-a231-5da2f81c54cf_p2" target="shh1_s_shh1_s326_shh1_shh1_sa179"> <start x="19823.688" y="549.8134"/> <end x="19892.0" y="523.0"/> </arc> <arc class="production" id="addprod_1baee9cb-6bf8-4ec2-89be-537056cbb7be" source="pr_92ec7fac-b93a-487b-a231-5da2f81c54cf_p2" target="shh1_s_shh1_s332_shh1_shh1_sa185"> <start x="19823.688" y="549.8134"/> <end x="19357.156" y="795.668"/> </arc> <arc class="consumption" id="cons_7567356f-ffa0-4947-8712-2622f6f86542" source="shh1_s_shh1_s357_shh1_shh1_sa168" target="pr_7faaa3c0-7351-4dd0-9846-fa571f186008_p1"> <start x="19860.0" y="310.0"/> <end x="18983.0" y="398.0"/> </arc> <arc class="production" id="prod_6f3c9822-c503-4e73-8911-74c1376f0aa2" source="pr_7faaa3c0-7351-4dd0-9846-fa571f186008_p2" target="shh1_s_shh2_s131_shh1_shh1_sa128"> <start x="18953.0" y="398.0"/> <end x="18076.0" y="486.0"/> </arc> <arc class="consumption" id="cons_942c56f0-bdda-4939-8187-b8ed3855bb20" source="shh1_s_shh2_s38_shh1_shh1_sa172" target="pr_17d42cab-90fb-462c-bfaa-be4926b1a4d6_p1"> <start x="18781.5" y="566.0"/> <end x="18819.5" y="566.0"/> </arc> <arc class="production" id="prod_9ade807e-607c-4b03-95dc-0e721238a036" source="pr_17d42cab-90fb-462c-bfaa-be4926b1a4d6_p2" target="shh1_s_shh2_s38_shh1_shh1_sa167"> <start x="18849.5" y="566.0"/> <end x="18887.5" y="566.0"/> </arc> <arc class="catalysis" id="modif_294d20a9-ec49-4752-b1ee-c443c7b36457" source="shh1_s_shh1_s320_shh1_shh1_sa173" target="pr_17d42cab-90fb-462c-bfaa-be4926b1a4d6"> <start x="18834.0" y="627.5"/> <end x="18834.5" y="571.0"/> </arc> <arc class="consumption" id="cons_340b8247-03e7-4b20-ac33-bdd944b811a9" source="shh1_s_shh1_s332_shh1_shh1_sa185" target="pr_61b4babe-2bce-4f26-bbbb-977ee4904d30_p1"> <start x="19361.5" y="815.668"/> <end x="19386.207" y="815.668"/> </arc> <arc class="production" id="prod_cd2f5b5e-e804-4f46-a1b3-86b03a04bea2" source="pr_61b4babe-2bce-4f26-bbbb-977ee4904d30_p2" target="shh1_s_shh1_s334_shh1_shh1_sa186"> <start x="19416.207" y="815.668"/> <end x="19440.916" y="815.668"/> </arc> <arc class="catalysis" id="modif_d8df3c7d-1e1b-4e9d-a6a1-b9b8c1a3f486" source="shh1_s_shh1_s332_shh1_shh1_sa185" target="pr_61b4babe-2bce-4f26-bbbb-977ee4904d30"> <start x="19321.5" y="835.668"/> <next x="19321.502" y="845.70087"/> <next x="19401.21" y="845.691"/> <end x="19401.207" y="820.668"/> </arc> <arc class="consumption" id="cons_b3d691dc-149b-4774-b0d7-546ce4fa0c88" source="shh1_s_shh1_s316_shh1_shh1_sa169" target="pr_ee4f912c-31e0-4a96-9ebf-1e6efb310950_p1"> <start x="20075.25" y="385.87875"/> <end x="19881.457" y="575.7734"/> </arc> <arc class="production" id="prod_991a1ee6-7ea6-4758-8b02-ab6fcadd18ad" source="pr_ee4f912c-31e0-4a96-9ebf-1e6efb310950_p2" target="shh1_s_shh1_s336_shh1_shh1_sa187"> <start x="19881.457" y="605.7734"/> <end x="19687.666" y="795.668"/> </arc> <arc class="catalysis" id="modif_72bfc1e4-e6b1-40c9-a6ed-dc11cf54e5d1" source="shh1_s_shh1_s334_shh1_shh1_sa186" target="pr_ee4f912c-31e0-4a96-9ebf-1e6efb310950"> <start x="19515.682" y="795.668"/> <end x="19877.824" y="587.33765"/> </arc> <arc class="consumption" id="cons_a735e3ed-6061-465c-8ffb-a03287cc7158" source="shh1_s_shh1_s318_shh1_shh1_sa171" target="pr_a36db2d6-53d7-43a9-bc39-b3028563f9e7_p1"> <start x="20075.25" y="489.0"/> <end x="20013.75" y="627.334"/> </arc> <arc class="production" id="prod_fa94d74f-9812-4b09-bfde-03f13e49365e" source="pr_a36db2d6-53d7-43a9-bc39-b3028563f9e7_p2" target="shh1_s_shh1_s318_shh1_shh1_sa189"> <start x="20013.75" y="657.334"/> <end x="19952.25" y="795.668"/> </arc> <arc class="consumption" id="cons_8ad6faa9-9d47-4e01-8eaf-6744c9236e36" source="shh1_s_shh1_s451_shh1_shh1_sa253" target="pr_23275ffb-152c-4f8c-a9e8-fc57683403c4_p1"> <start x="19947.912" y="949.0"/> <end x="19860.96" y="1345.0"/> </arc> <arc class="production" id="prod_ad94497e-8bfa-45ab-92a3-b0eb83fc360b" source="pr_23275ffb-152c-4f8c-a9e8-fc57683403c4_p2" target="shh1_s_shh1_s453_shh1_shh1_sa188"> <start x="19860.96" y="1375.0"/> <end x="19774.01" y="1771.0"/> </arc> <arc class="stimulation" id="modif_68dfd8b1-73e2-42b3-948d-be345a23f665" source="shh1_s_shh1_s366_shh1_shh1_sa197" target="pr_23275ffb-152c-4f8c-a9e8-fc57683403c4"> <start x="19754.617" y="1148.0"/> <end x="19856.068" y="1358.9651"/> </arc> <arc class="inhibition" id="modif_7549bf55-811b-4c5b-b3fc-b05f7b0fde27" source="shh1_s_shh1_s604_shh1_shh1_csa45" target="pr_23275ffb-152c-4f8c-a9e8-fc57683403c4"> <start x="19920.0" y="1380.0"/> <end x="19865.854" y="1361.0349"/> </arc> <arc class="stimulation" id="modif_322d8de2-23a6-4a78-8a44-7010ed9344e6" source="shh1_s_shh1_s602_shh1_shh1_csa53" target="pr_23275ffb-152c-4f8c-a9e8-fc57683403c4"> <start x="19702.5" y="1439.0"/> <end x="19855.035" y="1363.8568"/> </arc> <arc class="consumption" id="cons_abfe2f21-6f08-43a3-b786-4d33a47b9028" source="shh1_s_shh1_s358_shh1_shh1_csa24" target="pr_dcf1412f-bdb3-4c57-bbaa-30977feadfbc_p1"> <start x="19194.0" y="885.0"/> <end x="19250.375" y="873.8135"/> </arc> <arc class="production" id="prod_3ddc05a1-039a-4295-a2ab-39f225c15595" source="pr_dcf1412f-bdb3-4c57-bbaa-30977feadfbc_p2" target="shh1_s_shh1_s362_shh1_shh1_sa193"> <start x="19280.375" y="873.8135"/> <next x="19336.75" y="862.6269"/> <end x="19256.5" y="758.0"/> </arc> <arc class="production" id="prod_ce7eafa4-20b9-4dfa-8eee-c926fd828e62" source="pr_dcf1412f-bdb3-4c57-bbaa-30977feadfbc_p2" target="shh1_s_shh1_s361_shh1_shh1_sa192"> <start x="19280.375" y="873.8135"/> <next x="19336.75" y="862.6269"/> <end x="19365.5" y="894.0"/> </arc> <arc class="necessary stimulation" id="modif_d67db19f-d7ec-450c-aba9-e6241074279c" source="shh1_s_shh1_s1_shh1_shh1_sa1" target="pr_dcf1412f-bdb3-4c57-bbaa-30977feadfbc"> <start x="19295.0" y="229.0"/> <end x="19264.602" y="868.8738"/> </arc> <arc class="inhibition" id="modif_066bd92e-8d6a-4614-aad1-fea464ea9378" source="shh1_s_shh1_s600_shh1_shh1_csa48" target="pr_dcf1412f-bdb3-4c57-bbaa-30977feadfbc"> <start x="18186.5" y="244.0"/> <end x="19259.66" y="869.64795"/> </arc> <arc class="consumption" id="cons_36065773-c137-4b33-b5f6-997eb6713b01" source="shh1_s_shh1_s362_shh1_shh1_sa193" target="pr_409c9697-3e3f-44aa-bc14-bdfc8e340ddb_p1"> <start x="19218.244" y="718.0"/> <end x="19107.0" y="652.0"/> </arc> <arc class="production" id="prod_9dab3cac-f2d5-4aba-9029-841d8ca20866" source="pr_409c9697-3e3f-44aa-bc14-bdfc8e340ddb_p2" target="shh1_s_shh2_s38_shh1_shh1_sa167"> <start x="19077.0" y="652.0"/> <end x="18965.756" y="586.0"/> </arc> <arc class="consumption" id="cons_b1c9d871-dec0-47ed-b04b-75eef3a5ae96" source="shh1_s_shh1_s362_shh1_shh1_sa193" target="pr_ed5c5b4b-e42f-4fa4-8240-343a8bf2a386_p1"> <start x="19257.324" y="758.0"/> <end x="19278.2" y="1249.5"/> </arc> <arc class="production" id="prod_c90cb254-bead-40af-8767-121204d80c8b" source="pr_ed5c5b4b-e42f-4fa4-8240-343a8bf2a386_p2" target="shh1_s_shh1_s363_shh1_shh1_sa194"> <start x="19278.2" y="1279.5"/> <end x="19299.072" y="1771.0"/> </arc> <arc class="consumption" id="cons_ef91c7f9-4725-4ca4-8aa5-c2121e44f2ae" source="shh1_s_shh1_s361_shh1_shh1_sa192" target="pr_2d28e4fc-7af4-4e22-abfc-d67fe58bff94_p1"> <start x="19365.5" y="914.0"/> <next x="19346.75" y="941.0"/> <end x="19308.375" y="943.0779"/> </arc> <arc class="consumption" id="cons_9339a95f-7d79-4fab-b199-c6499b3474cc" source="shh1_s_shh1_s362_shh1_shh1_sa195" target="pr_2d28e4fc-7af4-4e22-abfc-d67fe58bff94_p1"> <start x="19365.5" y="969.0"/> <next x="19346.75" y="941.0"/> <end x="19308.375" y="943.0779"/> </arc> <arc class="production" id="prod_b3d555f2-301d-4ef0-b03b-df93bbf8ef0a" source="pr_2d28e4fc-7af4-4e22-abfc-d67fe58bff94_p2" target="shh1_s_shh1_s358_shh1_shh1_csa24"> <start x="19278.375" y="943.0779"/> <end x="19244.0" y="945.0"/> </arc> <arc class="necessary stimulation" id="modif_c722be1c-561c-45a1-b71e-1b19ae0953ff" source="shh1_s_shh1_s302_shh1_shh1_sa3" target="pr_2d28e4fc-7af4-4e22-abfc-d67fe58bff94"> <start x="19833.0" y="190.75"/> <end x="19293.18" y="938.08167"/> </arc> <arc class="consumption" id="cons_4599a908-55cb-42e2-8bdd-31b15b0f3e72" source="shh1_s_shh1_s450_shh1_shh1_sa252" target="pr_0be9ad5c-df28-4031-875a-76b838497d7f_p1"> <start x="19687.666" y="947.0"/> <end x="19587.645" y="1344.0"/> </arc> <arc class="production" id="prod_c6e38da8-30ab-4d80-8879-16db74037d8e" source="pr_0be9ad5c-df28-4031-875a-76b838497d7f_p2" target="shh1_s_shh1_s452_shh1_shh1_sa196"> <start x="19587.645" y="1374.0"/> <end x="19487.625" y="1771.0"/> </arc> <arc class="stimulation" id="modif_72332136-0a90-469a-a3d4-386cc5432843" source="shh1_s_shh1_s366_shh1_shh1_sa197" target="pr_0be9ad5c-df28-4031-875a-76b838497d7f"> <start x="19731.863" y="1148.0"/> <end x="19592.504" y="1360.1796"/> </arc> <arc class="stimulation" id="modif_14f41612-7a16-4a17-ad29-a604b4b193a9" source="shh1_s_shh1_s602_shh1_shh1_csa53" target="pr_0be9ad5c-df28-4031-875a-76b838497d7f"> <start x="19702.5" y="1439.0"/> <end x="19591.324" y="1365.0385"/> </arc> <arc class="consumption" id="cons_a5b457c9-7f6a-457e-8e78-7237bfc40b52" source="shh1_s_shh2_s131_shh1_shh1_sa198" target="pr_6460c20a-d923-42d7-9d26-8bc53f8bc7fb_p1"> <start x="20023.25" y="1128.0"/> <next x="19886.0" y="1263.5"/> <end x="19835.5" y="1286.9666"/> </arc> <arc class="consumption" id="cons_86d50a35-5b73-4839-8b5e-99f681fd3e9a" source="shh1_s638_shh1_shh1_sa199" target="pr_6460c20a-d923-42d7-9d26-8bc53f8bc7fb_p1"> <start x="20025.25" y="1250.5"/> <next x="19886.0" y="1263.5"/> <end x="19835.5" y="1286.9666"/> </arc> <arc class="production" id="prod_b5c781d4-4fdb-4302-8069-2cd3771e1b7f" source="pr_6460c20a-d923-42d7-9d26-8bc53f8bc7fb_p2" target="shh1_s665_shh1_shh1_csa25"> <start x="19805.5" y="1286.9666"/> <end x="19759.0" y="1309.0"/> </arc> <arc class="consumption" id="addreact_6da7e762-6770-4049-81cc-e28a999c72c1" source="shh1_s639_shh1_shh1_sa200" target="pr_6460c20a-d923-42d7-9d26-8bc53f8bc7fb_p1"> <start x="19985.75" y="1330.4702"/> <end x="19835.5" y="1286.9666"/> </arc> <arc class="consumption" id="cons_959612b5-f23a-4d99-862c-27c63eb1e1b7" source="shh1_s665_shh1_shh1_csa25" target="pr_95503dc1-3f2b-496a-86bb-61ccbb9a773b_p1"> <start x="19559.0" y="1309.0"/> <end x="19508.0" y="1309.0"/> </arc> <arc class="production" id="prod_f1ee6f20-5bac-4c2a-a928-461a6b5d3a1a" source="pr_95503dc1-3f2b-496a-86bb-61ccbb9a773b_p2" target="shh1_s_shh1_s372_shh1_shh1_csa26"> <start x="19478.0" y="1309.0"/> <end x="19427.0" y="1309.0"/> </arc> <arc class="catalysis" id="modif_5a14f238-3104-4c98-85a3-2f28dadbb436" source="shh1_s_shh2_s38_shh1_shh1_sa167" target="pr_95503dc1-3f2b-496a-86bb-61ccbb9a773b"> <start x="18927.5" y="586.0"/> <end x="19493.0" y="1304.0"/> </arc> <arc class="consumption" id="cons_dfed60d5-f1c7-43a0-9b79-05fc525dd553" source="shh1_s_shh1_s372_shh1_shh1_csa26" target="pr_c711f0b9-eb42-4fa2-8ac7-197342496ca3_p1"> <start x="19227.0" y="1309.0"/> <end x="19176.0" y="1309.0"/> </arc> <arc class="production" id="prod_1f9b50d5-c511-4cc0-9c82-01786ccd8c5a" source="pr_c711f0b9-eb42-4fa2-8ac7-197342496ca3_p2" target="shh1_s_shh1_s375_shh1_shh1_csa27"> <start x="19146.0" y="1309.0"/> <end x="19095.0" y="1309.0"/> </arc> <arc class="catalysis" id="modif_79d26a3f-6d7b-400e-a7d9-6b5534b76426" source="shh1_s_shh1_s255_shh1_shh1_sa126" target="pr_c711f0b9-eb42-4fa2-8ac7-197342496ca3"> <start x="18830.5" y="810.0"/> <end x="19166.0" y="1304.0"/> </arc> <arc class="catalysis" id="modif_37a441cc-3d39-4019-b703-18de38dd2188" source="shh1_s_shh1_s256_shh1_shh1_sa127" target="pr_c711f0b9-eb42-4fa2-8ac7-197342496ca3"> <start x="18722.5" y="809.0"/> <end x="19156.0" y="1304.0"/> </arc> <arc class="consumption" id="cons_bc325630-aa76-44fb-a1c8-45213fd7acda" source="shh1_s_shh1_s368_shh1_shh1_csa28" target="pr_c1bef285-82d5-4927-ae55-198305d821be_p1"> <start x="18995.0" y="1566.0"/> <end x="18995.0" y="1561.2378"/> </arc> <arc class="production" id="prod_f2f3dfcb-f4f4-4198-a44f-c1db76882251" source="pr_c1bef285-82d5-4927-ae55-198305d821be_p2" target="shh1_s_shh2_s131_shh1_shh1_sa210"> <start x="18995.0" y="1591.2378"/> <next x="18995.0" y="1586.4756"/> <end x="19074.25" y="1618.7703"/> </arc> <arc class="production" id="prod_2a999005-7b8f-4b72-b310-d920c829cc22" source="pr_c1bef285-82d5-4927-ae55-198305d821be_p2" target="shh1_s639_shh1_shh1_sa211"> <start x="18995.0" y="1591.2378"/> <next x="18995.0" y="1586.4756"/> <end x="18935.5" y="1618.7703"/> </arc> <arc class="production" id="addprod_8a3ab164-6420-470d-bc7b-8412eb7866ef" source="pr_c1bef285-82d5-4927-ae55-198305d821be_p2" target="shh1_s_shh1_s381_shh1_shh1_sa212"> <start x="18995.0" y="1591.2378"/> <end x="18751.25" y="1618.7703"/> </arc> <arc class="consumption" id="cons_c8d16c45-9217-4ecb-89f4-596aa3b65fdc" source="shh1_s_shh1_s381_shh1_shh1_sa212" target="pr_49050b0c-8b4d-4def-9601-e4e05fcb0e17_p1"> <start x="18668.75" y="1639.2703"/> <end x="18589.412" y="1639.2703"/> </arc> <arc class="production" id="prod_2a1ad618-0b5b-4faf-8932-e1617b1e2f14" source="pr_49050b0c-8b4d-4def-9601-e4e05fcb0e17_p2" target="shh1_s_shh1_s470_shh1_shh1_sa123"> <start x="18559.412" y="1639.2703"/> <end x="18480.074" y="1639.2703"/> </arc> <arc class="consumption" id="cons_edff88d8-3dc2-4bf5-befd-50a7eaf27393" source="shh1_s_shh1_s375_shh1_shh1_csa27" target="pr_3fb998b1-898d-4220-9ba8-a7408cb9f7d8_p1"> <start x="18995.0" y="1379.0"/> <end x="18995.0" y="1389.5"/> </arc> <arc class="production" id="prod_82c23f6b-9e4d-424f-a253-ca5ac60d5c62" source="pr_3fb998b1-898d-4220-9ba8-a7408cb9f7d8_p2" target="shh1_s_shh1_s368_shh1_shh1_csa28"> <start x="18995.0" y="1419.5"/> <end x="18995.0" y="1430.0"/> </arc> <arc class="catalysis" id="logicarc_3e1ca406-928c-436c-9c42-8328c9d611f6" source="logicglyph_905bc4d5-6341-4a0f-9dc6-9a978b2b5e35_p2" target="pr_3fb998b1-898d-4220-9ba8-a7408cb9f7d8"> <start x="18864.5" y="1310.25"/> <end x="18990.0" y="1404.5"/> </arc> <arc class="logic arc" id="modif_cee85042-d510-4a7c-a8ca-48c52b5c463f" source="shh1_s_shh1_s96_shh1_shh1_sa51" target="logicglyph_905bc4d5-6341-4a0f-9dc6-9a978b2b5e35_p1"> <start x="18864.0" y="1163.0"/> <end x="18824.5" y="1310.25"/> </arc> <arc class="logic arc" id="modif_2a2aeb21-ce21-422d-a995-5db5a8391199" source="shh1_s637_shh1_shh1_sa53" target="logicglyph_905bc4d5-6341-4a0f-9dc6-9a978b2b5e35_p1"> <start x="18711.0" y="1189.0"/> <end x="18824.5" y="1310.25"/> </arc> <arc class="logic arc" id="modif_09c49ac3-7838-4de7-b28f-11ff9afa1fea" source="shh1_s_shh1_s36_shh1_shh1_csa4" target="logicglyph_905bc4d5-6341-4a0f-9dc6-9a978b2b5e35_p1"> <start x="18832.0" y="1358.0"/> <end x="18824.5" y="1310.25"/> </arc> <arc class="consumption" id="cons_53d28ddd-f73d-45e3-be78-17bcc813f94a" source="shh1_s636_shh1_shh1_csa29" target="pr_7649a5da-2bc1-4b23-9c89-107b230136f4_p1"> <start x="18196.0" y="1058.0"/> <end x="18224.375" y="1058.0"/> </arc> <arc class="production" id="prod_57447b38-7aa1-4369-9c12-374be58b1bfa" source="pr_7649a5da-2bc1-4b23-9c89-107b230136f4_p2" target="shh1_s_shh1_s386_shh1_shh1_csa30"> <start x="18254.375" y="1058.0"/> <end x="18282.75" y="1058.0"/> </arc> <arc class="catalysis" id="modif_09428acf-ff2b-4d4c-976a-7a643b13fc0b" source="shh1_s_shh2_s38_shh1_shh1_sa167" target="pr_7649a5da-2bc1-4b23-9c89-107b230136f4"> <start x="18927.5" y="586.0"/> <end x="18239.375" y="1053.0"/> </arc> <arc class="consumption" id="cons_72272285-9885-4e37-ad3e-9c6e4f346d17" source="shh1_s_shh1_s386_shh1_shh1_csa30" target="pr_54b3d117-c816-40f8-9b83-619c9d80cbc6_p1"> <start x="18478.75" y="1058.0"/> <end x="18506.625" y="1058.0"/> </arc> <arc class="production" id="prod_3677f259-1a4b-403b-b058-7491420a5b6d" source="pr_54b3d117-c816-40f8-9b83-619c9d80cbc6_p2" target="shh1_s_shh1_s391_shh1_shh1_csa31"> <start x="18536.625" y="1058.0"/> <end x="18564.5" y="1058.0"/> </arc> <arc class="catalysis" id="modif_6227228f-782f-46d7-a187-b0970f2b91fb" source="shh1_s_shh1_s256_shh1_shh1_sa127" target="pr_54b3d117-c816-40f8-9b83-619c9d80cbc6"> <start x="18722.5" y="809.0"/> <end x="18516.625" y="1053.0"/> </arc> <arc class="catalysis" id="modif_679b47d1-c3e2-499c-9034-c46c18b9e008" source="shh1_s_shh1_s255_shh1_shh1_sa126" target="pr_54b3d117-c816-40f8-9b83-619c9d80cbc6"> <start x="18830.5" y="810.0"/> <end x="18526.625" y="1053.0"/> </arc> <arc class="consumption" id="cons_3f0a67c4-962a-4b3e-8e17-3eea515904e6" source="shh1_s_shh1_s394_shh1_shh1_csa32" target="pr_e037e5d4-152a-44de-965e-0c23fe3ed54d_p1"> <start x="18344.5" y="1324.0"/> <end x="18303.375" y="1323.0344"/> </arc> <arc class="production" id="prod_343118b5-19e9-4b0c-b3f1-184e0ed1e3ad" source="pr_e037e5d4-152a-44de-965e-0c23fe3ed54d_p2" target="shh1_s_shh2_s131_shh1_shh1_sa226"> <start x="18273.375" y="1323.0344"/> <next x="18232.25" y="1322.0688"/> <end x="18208.25" y="1262.0"/> </arc> <arc class="production" id="prod_95902d63-b86f-4af3-9f3d-07cef9642450" source="pr_e037e5d4-152a-44de-965e-0c23fe3ed54d_p2" target="shh1_s639_shh1_shh1_sa227"> <start x="18273.375" y="1323.0344"/> <next x="18232.25" y="1322.0688"/> <end x="18208.75" y="1322.0"/> </arc> <arc class="production" id="addprod_1f6307c7-cbbc-4f50-ae92-eda8aaf8aa71" source="pr_e037e5d4-152a-44de-965e-0c23fe3ed54d_p2" target="shh1_s_shh1_s412_shh1_shh1_sa228"> <start x="18273.375" y="1323.0344"/> <end x="18183.25" y="1368.0"/> </arc> <arc class="consumption" id="cons_f1767496-3d14-473a-8054-4700734bbd01" source="shh1_s_shh1_s412_shh1_shh1_sa228" target="pr_2a2c493f-b3b5-47f0-a2e2-f78f0808567c_p1"> <start x="18183.25" y="1406.0"/> <end x="18176.0" y="1497.5269"/> </arc> <arc class="production" id="prod_9ae9a99f-3be7-47d6-9e17-e80513709051" source="pr_2a2c493f-b3b5-47f0-a2e2-f78f0808567c_p2" target="shh1_s_shh1_s413_shh1_shh1_sa65"> <start x="18176.0" y="1527.5269"/> <end x="18168.75" y="1619.0538"/> </arc> <arc class="consumption" id="cons_b2a1f0f7-94b8-467f-b19d-71f9415a4083" source="shh1_s_shh1_s391_shh1_shh1_csa31" target="pr_2531f352-2816-45be-828d-6af7c1bd5d75_p1"> <start x="18564.5" y="1133.0"/> <end x="18518.5" y="1191.0"/> </arc> <arc class="production" id="prod_3176fa6c-a4b0-4bb3-89de-30fedc467203" source="pr_2531f352-2816-45be-828d-6af7c1bd5d75_p2" target="shh1_s_shh1_s394_shh1_shh1_csa32"> <start x="18488.5" y="1191.0"/> <end x="18442.5" y="1249.0"/> </arc> <arc class="catalysis" id="logicarc_f177f801-e7c0-4505-8967-ddcf5e5b2fe3" source="logicglyph_165c9709-4cb5-4e68-a79b-80d889995937_p2" target="pr_2531f352-2816-45be-828d-6af7c1bd5d75"> <start x="18620.25" y="1255.0"/> <end x="18506.945" y="1194.6235"/> </arc> <arc class="logic arc" id="modif_4a8529bc-501c-41e1-9250-ad575f6ddac9" source="shh1_s_shh1_s96_shh1_shh1_sa51" target="logicglyph_165c9709-4cb5-4e68-a79b-80d889995937_p1"> <start x="18864.0" y="1163.0"/> <end x="18660.25" y="1255.0"/> </arc> <arc class="logic arc" id="modif_f8424936-ab82-40ea-8f2a-746312504d64" source="shh1_s637_shh1_shh1_sa53" target="logicglyph_165c9709-4cb5-4e68-a79b-80d889995937_p1"> <start x="18711.0" y="1189.0"/> <end x="18660.25" y="1255.0"/> </arc> <arc class="logic arc" id="modif_13a73ac6-1552-4e5f-8370-4b3ebdc17aac" source="shh1_s_shh1_s36_shh1_shh1_csa4" target="logicglyph_165c9709-4cb5-4e68-a79b-80d889995937_p1"> <start x="18656.0" y="1358.0"/> <end x="18660.25" y="1255.0"/> </arc> <arc class="consumption" id="cons_791fc94c-5895-4bb8-9e53-d01c85c278be" source="shh1_s_shh2_s131_shh1_shh1_sa128" target="pr_3eb5e192-53ca-4374-b3d3-629d840beb22_p1"> <start x="18036.0" y="506.0"/> <end x="18062.531" y="604.1632"/> </arc> <arc class="production" id="prod_3baf39ca-6305-4a9a-bba9-9f33d1a4c374" source="pr_3eb5e192-53ca-4374-b3d3-629d840beb22_p2" target="shh1_s639_shh1_shh1_sa180"> <start x="18062.531" y="634.1632"/> <next x="18089.062" y="732.3264"/> <end x="18148.0" y="362.0"/> </arc> <arc class="production" id="prod_4e567a31-f775-4b9e-9348-1c4eb928b39c" source="pr_3eb5e192-53ca-4374-b3d3-629d840beb22_p2" target="shh1_s636_shh1_shh1_csa29"> <start x="18062.531" y="634.1632"/> <next x="18089.062" y="732.3264"/> <end x="18099.5" y="984.0"/> </arc> <arc class="consumption" id="addreact_88cb94ef-b914-4ebc-b019-f53ea8a886f7" source="shh1_s_shh1_s259_shh1_shh1_sa130" target="pr_3eb5e192-53ca-4374-b3d3-629d840beb22_p1"> <start x="18077.137" y="634.0"/> <end x="18062.531" y="604.1632"/> </arc> <arc class="consumption" id="cons_2a5587af-adfb-4718-a5e6-7f6209aef94b" source="shh1_s_shh1_s158_shh1_shh1_sa69" target="pr_c1035c50-48b6-49a1-a147-27f5041cab27_p1"> <start x="18511.0" y="1996.0"/> <end x="18882.25" y="1998.5"/> </arc> <arc class="production" id="prod_8f2b6b7f-5141-4c3e-8bee-ad937cadff6e" source="pr_c1035c50-48b6-49a1-a147-27f5041cab27_p2" target="shh1_s_shh1_s399_shh1_shh1_sa229"> <start x="18912.25" y="1998.5"/> <end x="19283.5" y="2001.0"/> </arc> <arc class="consumption" id="cons_91e2a135-de06-4337-8cb1-e97720423e72" source="shh1_s_shh2_s131_shh1_shh1_sa128" target="pr_f831cd9f-162d-41fb-9a21-fee5a27a2e48_p1"> <start x="18036.0" y="486.0"/> <next x="18170.0" y="585.5"/> <end x="18379.945" y="1173.75"/> </arc> <arc class="consumption" id="cons_eeed0422-ec03-4732-897e-13879822a71b" source="shh1_s_shh1_s259_shh1_shh1_sa130" target="pr_f831cd9f-162d-41fb-9a21-fee5a27a2e48_p1"> <start x="18087.5" y="653.5"/> <next x="18170.0" y="585.5"/> <end x="18379.945" y="1173.75"/> </arc> <arc class="production" id="prod_e150ceff-48df-43db-95cc-6c308177a09a" source="pr_f831cd9f-162d-41fb-9a21-fee5a27a2e48_p2" target="shh1_s636_shh1_shh1_csa34"> <start x="18379.945" y="1203.75"/> <end x="18588.5" y="1788.0"/> </arc> <arc class="consumption" id="addreact_9ac10682-358d-4ee2-b445-7f6f37ad3701" source="shh1_s639_shh1_shh1_sa180" target="pr_f831cd9f-162d-41fb-9a21-fee5a27a2e48_p1"> <start x="18148.0" y="362.0"/> <end x="18379.945" y="1173.75"/> </arc> <arc class="consumption" id="cons_1980f72a-0ed7-4b79-b412-c312101366fc" source="shh1_s636_shh1_shh1_csa34" target="pr_d87ec747-3811-4b41-8457-a15db6c2196e_p1"> <start x="18781.5" y="1788.0"/> <end x="18822.0" y="1788.0"/> </arc> <arc class="production" id="prod_386f62e6-0f91-46fc-ae6e-e46fa9f74272" source="pr_d87ec747-3811-4b41-8457-a15db6c2196e_p2" target="shh1_s_shh1_s405_shh1_shh1_csa35"> <start x="18852.0" y="1788.0"/> <end x="18892.5" y="1788.0"/> </arc> <arc class="catalysis" id="modif_28ddd09b-488e-436f-8a05-8daa351148eb" source="shh1_s_shh1_s430_shh1_shh1_sa242" target="pr_d87ec747-3811-4b41-8457-a15db6c2196e"> <start x="18837.0" y="2174.0"/> <end x="18837.0" y="1793.0"/> </arc> <arc class="consumption" id="cons_5e2fc58d-a8a2-4169-a993-8bd4c2b4f035" source="shh1_s_shh1_s405_shh1_shh1_csa35" target="pr_30fe98c3-8cdb-4949-ba10-c95dd27c4ec3_p1"> <start x="18989.0" y="1862.0"/> <end x="18989.125" y="1882.5"/> </arc> <arc class="production" id="prod_8ae40515-676e-48b9-9cde-4e7103763bfc" source="pr_30fe98c3-8cdb-4949-ba10-c95dd27c4ec3_p2" target="shh1_s_shh1_s414_shh1_shh1_csa36"> <start x="18989.125" y="1912.5"/> <end x="18989.25" y="1933.0"/> </arc> <arc class="catalysis" id="modif_d1991d5e-346e-4ac6-aea7-7d692df1f670" source="shh1_s_shh1_s256_shh1_shh1_sa127" target="pr_30fe98c3-8cdb-4949-ba10-c95dd27c4ec3"> <start x="18722.5" y="809.0"/> <end x="18984.143" y="1902.5176"/> </arc> <arc class="catalysis" id="modif_69caebcd-fd30-457a-9d88-8eab07fc987a" source="shh1_s_shh1_s255_shh1_shh1_sa126" target="pr_30fe98c3-8cdb-4949-ba10-c95dd27c4ec3"> <start x="18830.5" y="810.0"/> <end x="18984.107" y="1892.5176"/> </arc> <arc class="consumption" id="cons_ed392cbb-169d-48ca-a364-27a6d233fe56" source="shh1_s_shh1_s414_shh1_shh1_csa36" target="pr_6775f863-edfd-4876-988c-7be731ce4b1c_p1"> <start x="18892.75" y="2007.0"/> <end x="18854.312" y="2007.0"/> </arc> <arc class="production" id="prod_087ee94a-d037-4aaf-aae4-45357dd72ac8" source="pr_6775f863-edfd-4876-988c-7be731ce4b1c_p2" target="shh1_s662_shh1_shh1_csa37"> <start x="18824.312" y="2007.0"/> <end x="18785.875" y="2007.0"/> </arc> <arc class="catalysis" id="logicarc_d094eea2-8a73-4701-a0bf-1c2685892b5f" source="logicglyph_5e7ee1ae-bcce-4235-8745-127bad15bdeb_p2" target="pr_6775f863-edfd-4876-988c-7be731ce4b1c"> <start x="18724.5" y="1478.0"/> <end x="18834.312" y="2002.0"/> </arc> <arc class="logic arc" id="modif_0b60380f-42f6-436e-91e7-52fbec501551" source="shh1_s_shh1_s96_shh1_shh1_sa51" target="logicglyph_5e7ee1ae-bcce-4235-8745-127bad15bdeb_p1"> <start x="18864.0" y="1163.0"/> <next x="18785.088" y="1320.1786"/> <end x="18724.5" y="1438.0"/> </arc> <arc class="logic arc" id="modif_5879ed87-24fc-4ce7-97f3-221f8157c7f5" source="shh1_s637_shh1_shh1_sa53" target="logicglyph_5e7ee1ae-bcce-4235-8745-127bad15bdeb_p1"> <start x="18711.0" y="1189.0"/> <end x="18724.5" y="1438.0"/> </arc> <arc class="logic arc" id="modif_c636ea49-f9a8-4aaa-ab82-3d8262ed1c13" source="shh1_s_shh1_s36_shh1_shh1_csa4" target="logicglyph_5e7ee1ae-bcce-4235-8745-127bad15bdeb_p1"> <start x="18656.0" y="1358.0"/> <end x="18724.5" y="1438.0"/> </arc> <arc class="consumption" id="cons_9694bc49-aa61-453e-9c62-87edc433335d" source="shh1_s_shh1_s431_shh1_shh1_sa243" target="pr_f3e1b1dd-f79e-4e2d-9748-e09276b027c9_p1"> <start x="18467.732" y="2181.0"/> <end x="18323.902" y="1935.5269"/> </arc> <arc class="production" id="prod_a3e24bce-8644-434a-8a8c-02e312541eef" source="pr_f3e1b1dd-f79e-4e2d-9748-e09276b027c9_p2" target="shh1_s_shh1_s413_shh1_shh1_sa65"> <start x="18323.902" y="1905.5269"/> <end x="18180.07" y="1660.0538"/> </arc> <arc class="consumption" id="cons_4d5e348c-2495-462d-bb28-553ebd2f573f" source="shh1_s_shh1_s430_shh1_shh1_sa242" target="pr_e41b410c-96f1-4fdb-a747-4e359be92129_p1"> <start x="18877.0" y="2194.0"/> <end x="18912.75" y="2194.0"/> </arc> <arc class="production" id="prod_6c39d194-b86d-4201-8aa0-d214447f7be4" source="pr_e41b410c-96f1-4fdb-a747-4e359be92129_p2" target="shh1_s_shh1_s432_shh1_shh1_sa246"> <start x="18942.75" y="2194.0"/> <end x="18978.5" y="2194.0"/> </arc> <arc class="catalysis" id="modif_6a5c4017-4479-4275-9227-97a80a7f4008" source="shh1_s_shh1_s433_shh1_shh1_sa247" target="pr_e41b410c-96f1-4fdb-a747-4e359be92129"> <start x="18928.0" y="2287.0"/> <end x="18927.75" y="2199.0"/> </arc> <arc class="consumption" id="cons_6e633204-dd66-4453-aa67-d8ddfadca8cb" source="shh1_s_shh1_s336_shh1_shh1_sa187" target="pr_8f209eed-3e48-4766-b999-cd330026d83e_p1"> <start x="19687.666" y="834.668"/> <end x="19687.666" y="856.334"/> </arc> <arc class="production" id="prod_c56fa80a-e653-4e3c-ab53-f902f30a02d3" source="pr_8f209eed-3e48-4766-b999-cd330026d83e_p2" target="shh1_s_shh1_s450_shh1_shh1_sa252"> <start x="19687.666" y="886.334"/> <end x="19687.666" y="908.0"/> </arc> <arc class="catalysis" id="logicarc_2886dc77-79b1-4675-982e-6d2163b3f8d5" source="logicglyph_fe5a9169-157a-41d5-88a6-d61a33179bb0_p2" target="pr_8f209eed-3e48-4766-b999-cd330026d83e"> <start x="19971.5" y="869.5"/> <end x="19692.666" y="871.334"/> </arc> <arc class="logic arc" id="modif_9c91253c-e670-464f-ac68-19d502c5ea2d" source="shh1_s_shh1_s445_shh1_shh1_csa38" target="logicglyph_fe5a9169-157a-41d5-88a6-d61a33179bb0_p1"> <start x="20085.0" y="764.0"/> <end x="20011.5" y="869.5"/> </arc> <arc class="logic arc" id="modif_5487b8c6-6de8-4f21-a0ec-6bf5ff76a629" source="shh1_s_shh1_s448_shh1_shh1_sa250" target="logicglyph_fe5a9169-157a-41d5-88a6-d61a33179bb0_p1"> <start x="20095.0" y="884.0"/> <end x="20011.5" y="869.5"/> </arc> <arc class="logic arc" id="modif_ab8de2f5-fbd1-4208-a455-cb2dd64ab1eb" source="shh1_s_shh1_s449_shh1_shh1_sa251" target="logicglyph_fe5a9169-157a-41d5-88a6-d61a33179bb0_p1"> <start x="20095.0" y="955.0"/> <end x="20011.5" y="869.5"/> </arc> <arc class="consumption" id="cons_86d82cad-3390-49c5-b90a-0b96d391005a" source="shh1_s_shh1_s318_shh1_shh1_sa189" target="pr_a280c2e9-7200-435c-ab49-d22a3eae08dc_p1"> <start x="19952.25" y="836.668"/> <end x="19952.25" y="857.334"/> </arc> <arc class="production" id="prod_3f619814-7f94-4b5c-9c4f-34462734cf53" source="pr_a280c2e9-7200-435c-ab49-d22a3eae08dc_p2" target="shh1_s_shh1_s451_shh1_shh1_sa253"> <start x="19952.25" y="887.334"/> <end x="19952.25" y="908.0"/> </arc> <arc class="catalysis" id="logicarc_4bdf77e3-e379-4d2d-bc06-023cecb53f6e" source="logicglyph_b250bede-15dc-4162-a1f8-bb8538838816_p2" target="pr_a280c2e9-7200-435c-ab49-d22a3eae08dc"> <start x="20040.5" y="871.0"/> <end x="19957.25" y="872.334"/> </arc> <arc class="logic arc" id="modif_91d8546a-d7ef-43a8-82aa-c9579e17fd8e" source="shh1_s_shh1_s445_shh1_shh1_csa38" target="logicglyph_b250bede-15dc-4162-a1f8-bb8538838816_p1"> <start x="20085.0" y="764.0"/> <end x="20080.5" y="871.0"/> </arc> <arc class="logic arc" id="modif_ba5065be-c801-4ffe-89c2-4ebfed2ecde2" source="shh1_s_shh1_s448_shh1_shh1_sa250" target="logicglyph_b250bede-15dc-4162-a1f8-bb8538838816_p1"> <start x="20095.0" y="884.0"/> <end x="20080.5" y="871.0"/> </arc> <arc class="logic arc" id="modif_61d9a41f-b236-49ba-903d-6bc60def7ef6" source="shh1_s_shh1_s449_shh1_shh1_sa251" target="logicglyph_b250bede-15dc-4162-a1f8-bb8538838816_p1"> <start x="20095.0" y="955.0"/> <end x="20080.5" y="871.0"/> </arc> <arc class="consumption" id="cons_b858e9e1-07bf-4b40-8d02-839af98ebb94" source="shh1_s_shh1_s2_shh1_shh1_sa2" target="pr_4ffae97b-0f41-4e77-878a-43a3558d5c52_p1"> <start x="19576.0" y="64.0"/> <next x="19967.0" y="171.40001"/> <end x="19968.0" y="185.95001"/> </arc> <arc class="consumption" id="cons_38445856-4c7a-4954-8cf2-b87bb6c9072f" source="shh1_s_shh1_s454_shh1_shh1_sa254" target="pr_4ffae97b-0f41-4e77-878a-43a3558d5c52_p1"> <start x="19955.0" y="179.4"/> <next x="19967.0" y="171.40001"/> <end x="19968.0" y="185.95001"/> </arc> <arc class="production" id="prod_cb4b0644-8cf6-440c-ab86-2d64ef5f084d" source="pr_4ffae97b-0f41-4e77-878a-43a3558d5c52_p2" target="shh1_s_shh1_s456_shh1_shh1_csa39"> <start x="19968.0" y="155.95001"/> <end x="19969.0" y="170.5"/> </arc> <arc class="consumption" id="cons_b580f8c4-0f04-47ef-8d95-209977da3831" source="shh1_s_shh1_s2_shh1_shh1_sa2" target="pr_0d4c3c09-b449-4b0a-83bd-3aba72ae526e_p1"> <start x="19576.0" y="64.0"/> <next x="20176.0" y="178.59999"/> <end x="20180.0" y="178.54411"/> </arc> <arc class="consumption" id="cons_5b8729f3-6df5-4409-812d-7601bd2ba1fa" source="shh1_s_shh1_s458_shh1_shh1_sa257" target="pr_0d4c3c09-b449-4b0a-83bd-3aba72ae526e_p1"> <start x="20162.0" y="191.4"/> <next x="20176.0" y="178.59999"/> <end x="20180.0" y="178.54411"/> </arc> <arc class="production" id="prod_a403f8d1-b0ae-42f9-a65c-79107b487421" source="pr_0d4c3c09-b449-4b0a-83bd-3aba72ae526e_p2" target="shh1_s_shh1_s459_shh1_shh1_csa40"> <start x="20210.0" y="178.54411"/> <end x="20210.0" y="178.5"/> </arc> <arc class="consumption" id="cons_8b40628f-b61a-4b30-8a27-2da67d4eb2fa" source="shh1_s_shh1_s459_shh1_shh1_csa40" target="pr_4d1f724d-6239-4793-be82-bc656f82d8c7_p1"> <start x="20261.5" y="254.0"/> <end x="20267.25" y="1082.25"/> </arc> <arc class="production" id="prod_c0d179ee-94da-4f67-90b8-66315677227b" source="pr_4d1f724d-6239-4793-be82-bc656f82d8c7_p2" target="shh1_s_shh1_s462_shh1_shh1_csa41"> <start x="20267.25" y="1112.25"/> <end x="20273.0" y="1940.5"/> </arc> <arc class="consumption" id="cons_6e5785f3-841d-4d41-b1ce-98cfed5150d5" source="shh1_s_shh1_s1_shh1_shh1_sa1" target="pr_9a01eae0-6149-4575-855a-fdf6d653d246_p1"> <start x="19314.5" y="217.6"/> <next x="19356.0" y="274.0"/> <end x="19372.328" y="249.5"/> </arc> <arc class="consumption" id="cons_1097ac9a-44af-41b3-a77a-f115bf5f788f" source="shh1_s_shh1_s475_shh1_shh1_sa264" target="pr_9a01eae0-6149-4575-855a-fdf6d653d246_p1"> <start x="19301.0" y="339.0"/> <next x="19356.0" y="274.0"/> <end x="19372.328" y="249.5"/> </arc> <arc class="production" id="prod_3d08ce94-fba9-449f-b189-80fd32a36e44" source="pr_9a01eae0-6149-4575-855a-fdf6d653d246_p2" target="shh1_s_shh1_s473_shh1_shh1_csa42"> <start x="19372.328" y="219.5"/> <end x="19387.0" y="199.0"/> </arc> <arc class="consumption" id="cons_94606b3a-ea98-4ecd-bfe5-6343922a2f71" source="shh1_s_shh1_s477_shh1_shh1_sa266" target="pr_5877f74d-ed66-4ad4-8800-0d04e390553f_p1"> <start x="19179.0" y="336.81967"/> <end x="19205.0" y="347.90985"/> </arc> <arc class="production" id="prod_cde18449-66a5-4e73-a34c-6f289767b48d" source="pr_5877f74d-ed66-4ad4-8800-0d04e390553f_p2" target="shh1_s_shh1_s475_shh1_shh1_sa264"> <start x="19235.0" y="347.90985"/> <end x="19261.0" y="359.0"/> </arc> <arc class="consumption" id="cons_5f3e6649-75a7-46f7-85de-b463a6159622" source="shh1_s_shh1_s473_shh1_shh1_csa42" target="pr_c87e4333-21a2-44c2-bdde-b66d4d18ca18_p1"> <start x="19387.0" y="199.0"/> <end x="19384.5" y="202.58975"/> </arc> <arc class="production" id="prod_67600bde-907a-4a73-98bb-4fe11e2f3913" source="pr_c87e4333-21a2-44c2-bdde-b66d4d18ca18_p2" target="shh1_s_shh1_s475_shh1_shh1_sa264"> <start x="19354.5" y="202.58975"/> <next x="19352.0" y="206.17949"/> <end x="19301.0" y="339.0"/> </arc> <arc class="production" id="prod_81234a81-3b6e-498a-abae-2a24b558f7b1" source="pr_c87e4333-21a2-44c2-bdde-b66d4d18ca18_p2" target="shh1_s_shh1_s1_shh1_shh1_sa1"> <start x="19354.5" y="202.58975"/> <next x="19352.0" y="206.17949"/> <end x="19334.0" y="183.4"/> </arc> <arc class="catalysis" id="modif_c3e93956-6be0-4836-8128-a44992bbf203" source="shh1_s_shh1_s260_shh1_shh1_csa14" target="pr_c87e4333-21a2-44c2-bdde-b66d4d18ca18"> <start x="19140.5" y="261.5"/> <end x="19370.504" y="207.48776"/> </arc> <arc class="consumption" id="cons_11297378-8afe-4d46-b5bd-cb52893179cc" source="shh1_s_shh1_s478_shh1_shh1_sa267" target="pr_e69a7686-852e-4342-a7eb-0a7f3e377eb9_p1"> <start x="19347.5" y="1921.0"/> <end x="19375.25" y="1921.0"/> </arc> <arc class="production" id="prod_082d7732-c09e-492d-9fa7-0536a5d896c9" source="pr_e69a7686-852e-4342-a7eb-0a7f3e377eb9_p2" target="shh1_s_shh1_s479_shh1_shh1_sa268"> <start x="19405.25" y="1921.0"/> <end x="19433.0" y="1921.0"/> </arc> <arc class="consumption" id="cons_1321bb11-fde8-466d-af6a-7b0993230112" source="shh1_s_shh1_s475_shh1_shh1_sa264" target="pr_08ace704-ec2b-46a4-8d70-9d15b56a312c_p1"> <start x="19301.0" y="379.0"/> <end x="19304.25" y="1125.0"/> </arc> <arc class="production" id="prod_2121f946-745f-4055-a7b4-69599c5c7b78" source="pr_08ace704-ec2b-46a4-8d70-9d15b56a312c_p2" target="shh1_s_shh1_s478_shh1_shh1_sa267"> <start x="19304.25" y="1155.0"/> <end x="19307.5" y="1901.0"/> </arc> <arc class="consumption" id="cons_ae80e3a4-bc32-4f30-930d-e9d27cbcaa4a" source="shh1_s_shh1_s483_shh1_shh1_sa271" target="pr_5d2c6ca2-d9ee-4e3d-a397-396413997261_p1"> <start x="18946.0" y="2399.0"/> <next x="18982.5" y="2429.0"/> <end x="19010.25" y="2429.0"/> </arc> <arc class="consumption" id="cons_ce1fbda3-a997-472a-a4d5-507a061e0513" source="shh1_s_shh1_s484_shh1_shh1_sa272" target="pr_5d2c6ca2-d9ee-4e3d-a397-396413997261_p1"> <start x="18948.0" y="2465.0"/> <next x="18982.5" y="2429.0"/> <end x="19010.25" y="2429.0"/> </arc> <arc class="production" id="prod_0fd1678f-2372-4f7e-b88e-919d874457c8" source="pr_5d2c6ca2-d9ee-4e3d-a397-396413997261_p2" target="shh1_s_shh1_s488_shh1_shh1_csa43"> <start x="19040.25" y="2429.0"/> <end x="19064.0" y="2429.0"/> </arc> <arc class="consumption" id="cons_a48672f7-ef23-4b11-a861-24f1e58b18f8" source="shh1_s_shh2_s32_shh1_shh1_sa269" target="pr_ab664bfc-c274-43ca-9112-d50e90ded6d4_p1"> <start x="19296.5" y="2305.0"/> <end x="19296.375" y="2343.0"/> </arc> <arc class="production" id="prod_1e9938d6-b027-4005-9f6e-f3e4d639329a" source="pr_ab664bfc-c274-43ca-9112-d50e90ded6d4_p2" target="shh1_s_shh1_s482_shh1_shh1_sa270"> <start x="19296.375" y="2373.0"/> <end x="19296.25" y="2411.0"/> </arc> <arc class="catalysis" id="logicarc_1c47955d-35f7-4d21-bbac-3fc1d3b96fb1" source="logicglyph_38642b0f-7995-4c0c-882b-4f18933e89b3_p2" target="pr_ab664bfc-c274-43ca-9112-d50e90ded6d4"> <start x="19211.5" y="2351.25"/> <end x="19291.375" y="2357.9883"/> </arc> <arc class="logic arc" id="modif_31a42ca8-6752-42b8-bbf6-d8d14ac542de" source="shh1_s637_shh1_shh1_sa277" target="logicglyph_38642b0f-7995-4c0c-882b-4f18933e89b3_p1"> <start x="19154.0" y="2273.0"/> <end x="19171.5" y="2351.25"/> </arc> <arc class="logic arc" id="modif_856a6742-6306-4e58-8cc2-62fa67c3c59e" source="shh1_s640_shh1_shh1_sa278" target="logicglyph_38642b0f-7995-4c0c-882b-4f18933e89b3_p1"> <start x="19154.0" y="2335.0"/> <end x="19171.5" y="2351.25"/> </arc> <arc class="logic arc" id="modif_740d5b42-53b5-485c-b26f-c2cf3282dcfa" source="shh1_s_shh1_s488_shh1_shh1_csa43" target="logicglyph_38642b0f-7995-4c0c-882b-4f18933e89b3_p1"> <start x="19164.0" y="2429.0"/> <end x="19171.5" y="2351.25"/> </arc> <arc class="consumption" id="cons_b6fe6809-8efa-47f2-a9a8-990c832b4f34" source="shh1_s_shh2_s131_shh1_shh1_sa128" target="pr_fbe53401-96f1-487f-a2b4-0de202f62c9c_p1"> <start x="18036.0" y="506.0"/> <end x="18042.25" y="1353.0"/> </arc> <arc class="production" id="prod_06a26685-550d-4b4a-bb1b-2679810526f4" source="pr_fbe53401-96f1-487f-a2b4-0de202f62c9c_p2" target="shh1_s_shh1_s497_shh1_shh1_sa279"> <start x="18042.25" y="1383.0"/> <end x="18048.5" y="2230.0"/> </arc> <arc class="catalysis" id="logicarc_86658c3b-a9bf-4053-b485-b520089a1dc2" source="logicglyph_597a554d-7f77-40bb-baa3-a48765cdbb92_p2" target="pr_fbe53401-96f1-487f-a2b4-0de202f62c9c"> <start x="18177.5" y="1220.75"/> <end x="18047.25" y="1367.9637"/> </arc> <arc class="logic arc" id="modif_dfe02fe8-28df-4b66-8d3d-6c493837008d" source="shh1_s637_shh1_shh1_sa280" target="logicglyph_597a554d-7f77-40bb-baa3-a48765cdbb92_p1"> <start x="18145.0" y="1178.1724"/> <end x="18177.5" y="1180.75"/> </arc> <arc class="logic arc" id="modif_ce7e8786-4715-4d41-8fe4-4991c7045863" source="shh1_s640_shh1_shh1_sa281" target="logicglyph_597a554d-7f77-40bb-baa3-a48765cdbb92_p1"> <start x="18215.5" y="1175.0"/> <end x="18177.5" y="1180.75"/> </arc> <arc class="logic arc" id="modif_b5dd2d0a-bd2a-414e-b2ad-70dcb489f4b2" source="shh1_s_shh1_s498_shh1_shh1_sa282" target="logicglyph_597a554d-7f77-40bb-baa3-a48765cdbb92_p1"> <start x="18277.0" y="1176.6488"/> <end x="18177.5" y="1180.75"/> </arc> <arc class="logic arc" id="modif_11218d95-2a4d-4d84-9ea9-8f03a871d79e" source="shh1_s_shh1_s302_shh1_shh1_sa3" target="logicglyph_597a554d-7f77-40bb-baa3-a48765cdbb92_p1"> <start x="19833.0" y="190.75"/> <end x="18177.5" y="1180.75"/> </arc> <arc class="consumption" id="cons_4f13c50c-8f02-41e8-82f4-65cea1fda19e" source="shh1_s_shh2_s32_shh1_shh1_sa269" target="pr_bb282f58-a3cb-4171-a9fe-4e5152513097_p1"> <start x="19296.5" y="2265.0"/> <end x="19296.5" y="2231.5"/> </arc> <arc class="production" id="prod_548a4709-9230-4f83-9e79-ded854db5286" source="pr_bb282f58-a3cb-4171-a9fe-4e5152513097_p2" target="shh1_s_shh1_s499_shh1_shh1_sa283"> <start x="19296.5" y="2201.5"/> <end x="19296.5" y="2168.0"/> </arc> <arc class="consumption" id="cons_f7a39d50-2246-443b-9264-7de2ca29a1a3" source="shh1_s_shh2_s131_shh1_shh1_sa244" target="pr_9bc572a1-a3d3-46cd-bc40-ab8a0f8c6419_p1"> <start x="18512.5" y="2070.0"/> <next x="19371.5" y="2268.0"/> <end x="19398.75" y="2260.6523"/> </arc> <arc class="consumption" id="cons_e6aeac41-5c07-4788-ba46-5167668ad533" source="shh1_s_shh2_s32_shh1_shh1_sa269" target="pr_9bc572a1-a3d3-46cd-bc40-ab8a0f8c6419_p1"> <start x="19336.5" y="2275.0"/> <next x="19371.5" y="2268.0"/> <end x="19398.75" y="2260.6523"/> </arc> <arc class="production" id="prod_1a14be3a-026c-4d9d-b14f-60210cbc46e6" source="pr_9bc572a1-a3d3-46cd-bc40-ab8a0f8c6419_p2" target="shh1_s_shh1_s500_shh1_shh1_csa44"> <start x="19428.75" y="2260.6523"/> <end x="19452.0" y="2254.0"/> </arc> <arc class="consumption" id="cons_5b4d1106-fae8-4fee-9c06-eabf56db4a2e" source="shh1_s_shh1_s500_shh1_shh1_csa44" target="pr_ae04e48e-8012-4d92-b9c7-88d1fdbbc7b8_p1"> <start x="19452.0" y="2314.0"/> <end x="19423.25" y="2304.9153"/> </arc> <arc class="production" id="prod_1101e038-e7be-432f-9d5f-58dfbae17962" source="pr_ae04e48e-8012-4d92-b9c7-88d1fdbbc7b8_p2" target="shh1_s_shh2_s32_shh1_shh1_sa269"> <start x="19393.25" y="2304.9153"/> <next x="19364.5" y="2295.8306"/> <end x="19336.5" y="2295.0"/> </arc> <arc class="production" id="prod_3e63b8eb-f57f-4011-9f37-181c1a777ab7" source="pr_ae04e48e-8012-4d92-b9c7-88d1fdbbc7b8_p2" target="shh1_s_shh2_s131_shh1_shh1_sa244"> <start x="19393.25" y="2304.9153"/> <next x="19364.5" y="2295.8306"/> <end x="18512.5" y="2090.0"/> </arc> <arc class="catalysis" id="modif_b4ccc646-196f-4620-b492-09d40b2b5850" source="shh1_s_shh1_s508_shh1_shh1_sa289" target="pr_ae04e48e-8012-4d92-b9c7-88d1fdbbc7b8"> <start x="19423.0" y="2413.0"/> <end x="19407.234" y="2309.8108"/> </arc> <arc class="consumption" id="cons_0208f27e-01f9-472e-912a-cabac719b78b" source="shh1_s_shh2_s131_shh1_shh1_sa244" target="pr_4524e0c9-b66e-402c-94ac-d50bc78286d2_p1"> <start x="18512.5" y="2050.0"/> <next x="19480.0" y="2284.0"/> <end x="19541.5" y="2284.0"/> </arc> <arc class="consumption" id="cons_630e7e00-b94b-45ad-830e-9374e38df9a5" source="shh1_s_shh1_s508_shh1_shh1_sa289" target="pr_4524e0c9-b66e-402c-94ac-d50bc78286d2_p1"> <start x="19463.0" y="2433.0"/> <next x="19480.0" y="2284.0"/> <end x="19541.5" y="2284.0"/> </arc> <arc class="production" id="prod_4052c717-253a-4ae8-aff2-a011b1144ae9" source="pr_4524e0c9-b66e-402c-94ac-d50bc78286d2_p2" target="shh1_s_shh1_s507_shh1_shh1_csa46"> <start x="19571.5" y="2284.0"/> <end x="19629.0" y="2284.0"/> </arc> <arc class="catalysis" id="modif_70898ec9-1df9-435e-968b-46e03744b80e" source="shh1_s_shh1_s513_shh1_shh1_sa292" target="pr_4524e0c9-b66e-402c-94ac-d50bc78286d2"> <start x="19554.0" y="2402.0"/> <end x="19556.5" y="2289.0"/> </arc> <arc class="consumption" id="cons_4f062171-bf0d-4611-ab95-f419b5f65b72" source="shh1_s_shh1_s514_shh1_shh1_sa293" target="pr_364f21cf-482a-4942-83bc-f906b6f22fbc_p1"> <start x="19510.62" y="2478.0"/> <end x="19524.562" y="2475.0"/> </arc> <arc class="production" id="prod_8b863498-fb87-488b-a56d-7b70f2b58119" source="pr_364f21cf-482a-4942-83bc-f906b6f22fbc_p2" target="shh1_s_shh1_s513_shh1_shh1_sa292"> <start x="19524.562" y="2445.0"/> <end x="19538.508" y="2442.0"/> </arc> <arc class="consumption" id="cons_b58cc3d4-4986-4cef-9523-cc4fc126234d" source="shh1_s_shh1_s255_shh1_shh1_sa126" target="pr_16b7d880-e6af-4139-9482-cde2cb85574d_p1"> <start x="18870.5" y="790.0"/> <end x="18879.0" y="790.0"/> </arc> <arc class="production" id="prod_a8941522-c1f5-4cc0-9e07-18714714c64d" source="pr_16b7d880-e6af-4139-9482-cde2cb85574d_p2" target="shh1_s_shh1_s516_shh1_shh1_sa294"> <start x="18909.0" y="790.0"/> <end x="18917.5" y="790.0"/> </arc> <arc class="catalysis" id="modif_837649e2-2c2d-4023-938f-804578002317" source="shh1_s_shh1_s515_shh1_shh1_sa295" target="pr_16b7d880-e6af-4139-9482-cde2cb85574d"> <start x="18894.0" y="714.0"/> <end x="18894.0" y="785.0"/> </arc> <arc class="catalysis" id="modif_c7a9c32f-373a-4363-8523-4deb847843b6" source="shh1_s_shh1_s600_shh1_shh1_csa48" target="pr_16b7d880-e6af-4139-9482-cde2cb85574d"> <start x="18186.5" y="244.0"/> <end x="18889.0" y="785.0"/> </arc> <arc class="consumption" id="cons_c07edad2-d4d6-4736-b491-830b1cb74500" source="shh1_s_shh1_s517_shh1_shh1_sa296" target="pr_3a24f09b-48fa-4dfd-b949-7871006952b3_p1"> <start x="18796.0" y="694.0"/> <end x="18810.0" y="694.0"/> </arc> <arc class="production" id="prod_b5e9d704-265d-41c1-a48e-ee77e7f50e40" source="pr_3a24f09b-48fa-4dfd-b949-7871006952b3_p2" target="shh1_s_shh1_s515_shh1_shh1_sa295"> <start x="18840.0" y="694.0"/> <end x="18854.0" y="694.0"/> </arc> <arc class="consumption" id="cons_6203f844-b80e-4d76-be63-c21802d8a3b3" source="shh1_s668_shh1_shh1_csa47" target="pr_e43b63cc-e3d7-49a0-a1ff-c83a3dc88b89_p1"> <start x="18088.0" y="184.0"/> <end x="18097.25" y="184.0"/> </arc> <arc class="production" id="prod_39bbebb6-ad25-419d-8311-8bdee682685e" source="pr_e43b63cc-e3d7-49a0-a1ff-c83a3dc88b89_p2" target="shh1_s_shh1_s600_shh1_shh1_csa48"> <start x="18127.25" y="184.0"/> <end x="18136.5" y="184.0"/> </arc> <arc class="catalysis" id="modif_ed37c3bc-c3f8-4edb-9b72-ac5095b7a348" source="shh1_s_shh1_s302_shh1_shh1_sa3" target="pr_e43b63cc-e3d7-49a0-a1ff-c83a3dc88b89"> <start x="19833.0" y="190.75"/> <end x="18112.25" y="189.0"/> </arc> <arc class="consumption" id="cons_a2371fe2-dbd3-4346-b882-c4b06c5e50ef" source="shh1_s_shh1_s517_shh1_shh1_sa296" target="pr_c296338e-2b20-4504-939b-94583aa19190_p1"> <start x="18732.066" y="679.0"/> <end x="18400.033" y="461.5"/> </arc> <arc class="production" id="prod_13695a7c-91ec-4f52-bf39-f5d6934270b3" source="pr_c296338e-2b20-4504-939b-94583aa19190_p2" target="shh1_s668_shh1_shh1_csa47"> <start x="18370.033" y="461.5"/> <end x="18038.0" y="244.0"/> </arc> <arc class="consumption" id="cons_f480538c-f1d5-40eb-9a49-a44f127eea2e" source="shh1_s_shh1_s559_shh1_shh1_sa321" target="pr_41ded531-331d-4681-825c-5ed9d7114e8e_p1"> <start x="19625.0" y="1617.0"/> <next x="19558.0" y="1574.0"/> <end x="19538.5" y="1574.0"/> </arc> <arc class="consumption" id="cons_7efadf33-ce24-4846-b483-0bd24f5798d2" source="shh1_s_shh1_s602_shh1_shh1_csa53" target="pr_41ded531-331d-4681-825c-5ed9d7114e8e_p1"> <start x="19577.0" y="1483.5"/> <next x="19558.0" y="1574.0"/> <end x="19538.5" y="1574.0"/> </arc> <arc class="production" id="prod_4880bbd6-4dbe-4ae3-9c5a-4522cb96eb30" source="pr_41ded531-331d-4681-825c-5ed9d7114e8e_p2" target="shh1_s_shh1_s603_shh1_shh1_csa54"> <start x="19508.5" y="1574.0"/> <end x="19493.0" y="1574.0"/> </arc> <arc class="consumption" id="cons_247ee588-0c60-4f97-9289-3dfebddf716a" source="shh1_s_shh1_s605_shh1_shh1_csa55" target="pr_62bed115-22a8-41ab-9608-9d3622c64dab_p1"> <start x="19892.5" y="723.0"/> <end x="19669.75" y="1102.0"/> </arc> <arc class="production" id="prod_7c099bab-1866-418f-a21a-5c7bc077aa4e" source="pr_62bed115-22a8-41ab-9608-9d3622c64dab_p2" target="shh1_s_shh1_s603_shh1_shh1_csa54"> <start x="19669.75" y="1132.0"/> <end x="19447.0" y="1511.0"/> </arc> <arc class="stimulation" id="modif_8232bce4-b54e-4bff-9180-2ec5035e3c18" source="shh1_s_shh1_s366_shh1_shh1_sa197" target="pr_62bed115-22a8-41ab-9608-9d3622c64dab"> <start x="19705.0" y="1128.0"/> <end x="19674.104" y="1119.4607"/> </arc> <arc class="consumption" id="cons_bc1facce-4f75-4bc9-ad3a-d2798f3a711e" source="shh1_s_shh1_s603_shh1_shh1_csa54" target="pr_3dcea67b-9f59-40c5-80bf-c24cf106c745_p1"> <start x="19355.0" y="1511.0"/> <end x="19577.75" y="1132.0"/> </arc> <arc class="production" id="prod_a69424f6-e349-45c9-ac80-1a542a477c87" source="pr_3dcea67b-9f59-40c5-80bf-c24cf106c745_p2" target="shh1_s_shh1_s605_shh1_shh1_csa55"> <start x="19577.75" y="1102.0"/> <end x="19800.5" y="723.0"/> </arc> <arc class="stimulation" id="modif_d309dbd0-a8ad-44a0-8dcb-eacd785c92a0" source="shh1_s_shh1_s565_shh1_shh1_sa326" target="pr_3dcea67b-9f59-40c5-80bf-c24cf106c745"> <start x="19515.0" y="1128.0"/> <end x="19573.396" y="1114.5393"/> </arc> <arc class="consumption" id="cons_c4d71206-b1d5-4dbf-93e2-0a8019a6e61c" source="shh1_s_shh1_s573_shh1_shh1_csa57" target="pr_2f15a9a4-f8a0-438f-a6ee-a847f5ad4c22_p1"> <start x="19518.0" y="204.0"/> <end x="19373.5" y="212.875"/> </arc> <arc class="production" id="prod_0bd76e30-9b17-410b-afe4-0c9c230fe4b9" source="pr_2f15a9a4-f8a0-438f-a6ee-a847f5ad4c22_p2" target="shh1_s_shh1_s260_shh1_shh1_csa14"> <start x="19343.5" y="212.875"/> <end x="19199.0" y="221.75"/> </arc> <arc class="consumption" id="cons_9d84e118-68a8-40ec-9bd2-e5675f6bfce9" source="shh1_s_shh1_s571_shh1_shh1_csa56" target="pr_77a5f3bf-d915-4730-a660-6bee248a4f7b_p1"> <start x="19613.0" y="205.75"/> <end x="19421.0" y="233.625"/> </arc> <arc class="production" id="prod_32b24202-e44c-4e62-9a8c-0bd8f4dc05f4" source="pr_77a5f3bf-d915-4730-a660-6bee248a4f7b_p2" target="shh1_s_shh1_s260_shh1_shh1_csa14"> <start x="19391.0" y="233.625"/> <end x="19199.0" y="261.5"/> </arc> <arc class="consumption" id="cons_d59f3541-b645-4dc4-a683-63808e82d233" source="shh1_s_shh1_s576_shh1_shh1_csa58" target="pr_a434b0f3-22a7-44bf-8a9b-f56d890501ca_p1"> <start x="19706.0" y="205.0"/> <end x="19467.5" y="233.25"/> </arc> <arc class="production" id="prod_dcfe8fe8-c058-4a94-a792-a0c9de8301a7" source="pr_a434b0f3-22a7-44bf-8a9b-f56d890501ca_p2" target="shh1_s_shh1_s260_shh1_shh1_csa14"> <start x="19437.5" y="233.25"/> <end x="19199.0" y="261.5"/> </arc> <arc class="consumption" id="cons_375e54f7-8d44-400c-9201-f5ebadcdf220" source="shh1_s_shh1_s285_shh1_shh1_sa350" target="pr_bfcb33c8-1c99-42d4-9d0d-7071c353660a_p1"> <start x="18145.5" y="285.0"/> <next x="18457.875" y="552.0"/> <end x="18489.438" y="551.7388"/> </arc> <arc class="consumption" id="cons_7c39dc6f-1edd-4b21-8d44-a646c062c3b2" source="shh1_s_shh1_s593_shh1_shh1_csa61" target="pr_bfcb33c8-1c99-42d4-9d0d-7071c353660a_p1"> <start x="18333.0" y="361.0"/> <next x="18457.875" y="552.0"/> <end x="18489.438" y="551.7388"/> </arc> <arc class="production" id="prod_6962cd91-3381-4442-a300-05c6b5e8aa6a" source="pr_bfcb33c8-1c99-42d4-9d0d-7071c353660a_p2" target="shh1_s_shh1_s596_shh1_shh1_csa62"> <start x="18519.438" y="551.7388"/> <end x="18547.0" y="551.5"/> </arc> <arc class="consumption" id="cons_d2e794ff-03cc-4414-9247-f52f97b841e6" source="shh1_s_shh2_s100_shh1_shh2_sa2" target="pr_0076cecd-3efd-45ec-8e62-eb6ca2b0b745_p1"> <start x="20010.375" y="3069.0"/> <end x="20009.875" y="3179.5"/> </arc> <arc class="production" id="prod_fcf9cc67-1f79-4785-92bb-064f96d68883" source="pr_0076cecd-3efd-45ec-8e62-eb6ca2b0b745_p2" target="shh1_s_shh2_s9_shh1_shh2_sa6"> <start x="20009.875" y="3209.5"/> <end x="20009.375" y="3320.0"/> </arc> <arc class="catalysis" id="logicarc_ca284f21-ad27-45ce-a658-539253e92087" source="logicglyph_04731d10-ae18-4380-8add-f3cb46a2c495_p2" target="pr_0076cecd-3efd-45ec-8e62-eb6ca2b0b745"> <start x="19886.25" y="3256.25"/> <end x="20004.875" y="3194.48"/> </arc> <arc class="logic arc" id="modif_bd037e11-c62d-4a46-a65d-15b855e63667" source="shh1_s_shh2_s10_shh1_shh2_sa7" target="logicglyph_04731d10-ae18-4380-8add-f3cb46a2c495_p1"> <start x="19823.5" y="3148.0"/> <end x="19846.25" y="3256.25"/> </arc> <arc class="logic arc" id="modif_8e0cae0b-28ac-4096-b998-91c5196f06c7" source="shh1_s_shh2_s11_shh1_shh2_sa8" target="logicglyph_04731d10-ae18-4380-8add-f3cb46a2c495_p1"> <start x="19823.5" y="3242.0"/> <end x="19846.25" y="3256.25"/> </arc> <arc class="logic arc" id="modif_151bab5d-8238-4b35-b3ec-262e605cb90a" source="shh1_s_shh2_s5_shh1_shh2_csa1" target="logicglyph_04731d10-ae18-4380-8add-f3cb46a2c495_p1"> <start x="19833.5" y="3376.0"/> <end x="19846.25" y="3256.25"/> </arc> <arc class="consumption" id="cons_559c8cdf-5275-480e-8b3b-22188706a913" source="shh1_s_shh2_s13_shh1_shh2_sa10" target="pr_defea2b7-007b-4676-851e-b646c3b9ca4b_p1"> <start x="18356.0" y="3166.75"/> <next x="18390.5" y="3171.0"/> <end x="18393.25" y="3172.127"/> </arc> <arc class="consumption" id="cons_97c07747-482a-49b8-ad1a-7e9167aa399b" source="shh1_s_shh2_s14_shh1_shh2_sa11" target="pr_defea2b7-007b-4676-851e-b646c3b9ca4b_p1"> <start x="18345.0" y="3222.0"/> <next x="18390.5" y="3171.0"/> <end x="18393.25" y="3172.127"/> </arc> <arc class="production" id="prod_10524044-442e-4924-9498-23643dde33c3" source="pr_defea2b7-007b-4676-851e-b646c3b9ca4b_p2" target="shh1_s_shh2_s336_shh1_shh2_csa2"> <start x="18423.25" y="3172.127"/> <end x="18422.0" y="3173.0"/> </arc> <arc class="consumption" id="addreact_9f6d8af8-84ba-4a8b-80f7-766724e3b5f8" source="shh1_s_shh2_s242_shh1_shh2_sa210" target="pr_defea2b7-007b-4676-851e-b646c3b9ca4b_p1"> <start x="18271.0" y="3110.0"/> <end x="18393.25" y="3172.127"/> </arc> <arc class="consumption" id="addreact_08ae6689-9794-46c1-aeac-e5d224997825" source="shh1_s_shh2_s243_shh1_shh2_sa211" target="pr_defea2b7-007b-4676-851e-b646c3b9ca4b_p1"> <start x="18353.0" y="3110.0"/> <end x="18393.25" y="3172.127"/> </arc> <arc class="consumption" id="cons_0664ae1c-45c9-48e0-aaf9-5e1cb76fd0a7" source="shh1_s_shh2_s18_shh1_shh2_sa14" target="pr_c6271bd1-7c2e-483e-bc7a-46a54fc0cfec_p1"> <start x="18757.0" y="3046.0"/> <end x="18783.5" y="3046.0"/> </arc> <arc class="production" id="prod_aad2f31b-e1b8-4e53-880e-299773e4225f" source="pr_c6271bd1-7c2e-483e-bc7a-46a54fc0cfec_p2" target="shh1_s_shh2_s19_shh1_shh2_sa15"> <start x="18813.5" y="3046.0"/> <end x="18840.0" y="3046.0"/> </arc> <arc class="inhibition" id="modif_6a1c3725-e8f5-4453-b899-b0210e198428" source="shh1_s_shh2_s336_shh1_shh2_csa2" target="pr_c6271bd1-7c2e-483e-bc7a-46a54fc0cfec"> <start x="18599.0" y="3173.0"/> <end x="18798.5" y="3051.0"/> </arc> <arc class="consumption" id="cons_692cd46a-f256-45e8-9518-d278480a50ee" source="shh1_s_shh2_s19_shh1_shh2_sa15" target="pr_b9a82f4f-4bee-4405-b013-bf761eb83ea9_p1"> <start x="18930.0" y="3044.3623"/> <end x="19018.5" y="3030.8018"/> </arc> <arc class="production" id="prod_806073ba-5998-468f-a5e9-6146f6e47091" source="pr_b9a82f4f-4bee-4405-b013-bf761eb83ea9_p2" target="shh1_s_shh2_s20_shh1_shh2_sa16"> <start x="19048.5" y="3030.8018"/> <end x="19137.0" y="3017.241"/> </arc> <arc class="consumption" id="cons_8619c786-7885-45d4-90c1-1e4799f016c1" source="shh1_s_shh2_s20_shh1_shh2_sa16" target="pr_14dba99a-e124-462a-9b83-4c31d56c7093_p1"> <start x="19177.0" y="3027.0"/> <end x="19177.0" y="3035.5"/> </arc> <arc class="production" id="prod_90be401c-4fd1-400c-84f3-a36a4ba80c06" source="pr_14dba99a-e124-462a-9b83-4c31d56c7093_p2" target="shh1_s_shh2_s21_shh1_shh2_sa17"> <start x="19177.0" y="3065.5"/> <end x="19177.0" y="3074.0"/> </arc> <arc class="consumption" id="cons_604f982d-2f5f-4905-a374-385d37a03328" source="shh1_s_shh2_s22_shh1_shh2_sa21" target="pr_6a271784-4e61-41bf-9d13-b454e849fc0c_p1"> <start x="18315.375" y="3448.0"/> <end x="18315.188" y="3432.0"/> </arc> <arc class="production" id="prod_e5cda18c-9f45-46bd-b866-685781e6d287" source="pr_6a271784-4e61-41bf-9d13-b454e849fc0c_p2" target="shh1_s_shh2_s25_shh1_shh2_sa18"> <start x="18315.188" y="3402.0"/> <end x="18315.0" y="3386.0"/> </arc> <arc class="catalysis" id="modif_b6c32e56-846a-41aa-ac2c-40a285fc315b" source="shh1_s_shh2_s24_shh1_shh2_sa22" target="pr_6a271784-4e61-41bf-9d13-b454e849fc0c"> <start x="18391.0" y="3417.0"/> <end x="18320.188" y="3416.9697"/> </arc> <arc class="consumption" id="cons_3a031e91-930a-4f65-a865-b311dd9a08dc" source="shh1_s_shh2_s22_shh1_shh2_sa21" target="pr_8ac65c06-cb6c-4ffd-a06d-216090702a62_p1"> <start x="18315.375" y="3488.0"/> <next x="18377.0" y="3511.0"/> <end x="18377.0" y="3567.5"/> </arc> <arc class="consumption" id="cons_ad59bc31-f890-4de6-90b6-44a2224b3723" source="shh1_s_shh2_s23_shh1_shh2_sa20" target="pr_8ac65c06-cb6c-4ffd-a06d-216090702a62_p1"> <start x="18432.0" y="3492.0"/> <next x="18377.0" y="3511.0"/> <end x="18377.0" y="3567.5"/> </arc> <arc class="production" id="prod_86cb3b16-4e35-4cba-93c8-19cad291176e" source="pr_8ac65c06-cb6c-4ffd-a06d-216090702a62_p2" target="shh1_s_shh2_s26_shh1_shh2_csa3"> <start x="18377.0" y="3597.5"/> <end x="18377.0" y="3650.0"/> </arc> <arc class="consumption" id="cons_3b1b9ea4-3c92-496f-a839-7097088841e3" source="shh1_s_shh2_s26_shh1_shh2_csa3" target="pr_e7c96d87-44b9-419b-bff7-0130c8a629f6_p1"> <start x="18327.0" y="3710.0"/> <end x="18248.75" y="3710.0"/> </arc> <arc class="production" id="prod_d8c07206-7a8e-4d94-9575-2ae32e0b498f" source="pr_e7c96d87-44b9-419b-bff7-0130c8a629f6_p2" target="shh1_s_shh2_s29_shh1_shh2_csa4"> <start x="18218.75" y="3710.0"/> <end x="18140.5" y="3710.0"/> </arc> <arc class="consumption" id="cons_b62f8678-2a2c-4be4-bd06-1ad0bea68ace" source="shh1_s_shh2_s29_shh1_shh2_csa4" target="pr_9929247c-6813-468e-a4b1-cdc7db483632_p1"> <start x="18090.5" y="3650.0"/> <end x="18090.258" y="3610.5156"/> </arc> <arc class="production" id="prod_bf02c7f2-541c-407c-8d1d-466e724a7aac" source="pr_9929247c-6813-468e-a4b1-cdc7db483632_p2" target="shh1_s650_shh1_shh2_sa27"> <start x="18090.258" y="3580.5156"/> <next x="18090.018" y="3541.0312"/> <end x="18026.75" y="3488.0"/> </arc> <arc class="production" id="prod_0f138992-c2db-4686-9495-01f087506f55" source="pr_9929247c-6813-468e-a4b1-cdc7db483632_p2" target="shh1_s_shh2_s33_shh1_shh2_sa28"> <start x="18090.258" y="3580.5156"/> <next x="18090.018" y="3541.0312"/> <end x="18142.0" y="3488.0"/> </arc> <arc class="consumption" id="cons_3102267e-e81b-4076-91f8-3acc8ae9ca27" source="shh1_s_shh2_s14_shh1_shh2_sa11" target="pr_a8d3ab4d-4c80-4ba7-9af2-a32b4e35fa8b_p1"> <start x="18345.0" y="3222.0"/> <next x="18395.0" y="3311.0"/> <end x="18417.5" y="3311.0"/> </arc> <arc class="consumption" id="cons_bd61ee62-50f6-48af-bdf6-66377be526a7" source="shh1_s_shh2_s25_shh1_shh2_sa18" target="pr_a8d3ab4d-4c80-4ba7-9af2-a32b4e35fa8b_p1"> <start x="18355.0" y="3366.0"/> <next x="18395.0" y="3311.0"/> <end x="18417.5" y="3311.0"/> </arc> <arc class="production" id="prod_b6646808-6484-447e-bcae-20417143c6dc" source="pr_a8d3ab4d-4c80-4ba7-9af2-a32b4e35fa8b_p2" target="shh1_s_shh2_s337_shh1_shh2_csa5"> <start x="18447.5" y="3311.0"/> <end x="18466.0" y="3311.0"/> </arc> <arc class="catalysis" id="modif_ec129cb5-7e3b-4422-8be4-e5a5107e5b42" source="shh1_s_shh2_s24_shh1_shh2_sa22" target="pr_a8d3ab4d-4c80-4ba7-9af2-a32b4e35fa8b"> <start x="18431.0" y="3397.0"/> <end x="18432.5" y="3316.0"/> </arc> <arc class="consumption" id="cons_301014fb-cda9-490d-b9c5-65ec748361ce" source="shh1_s650_shh1_shh2_sa27" target="pr_c70de91a-8496-4b28-a13b-f7be77e318df_p1"> <start x="18066.75" y="3468.0"/> <end x="18156.062" y="3468.0"/> </arc> <arc class="production" id="prod_a6fe13fb-c43e-4d9a-8599-27a009375ad7" source="pr_c70de91a-8496-4b28-a13b-f7be77e318df_p2" target="shh1_s_shh2_s22_shh1_shh2_sa21"> <start x="18186.062" y="3468.0"/> <end x="18275.375" y="3468.0"/> </arc> <arc class="consumption" id="cons_20c782e5-86d5-44c9-a5fd-72da73c9a89e" source="shh1_s650_shh1_shh2_sa27" target="pr_77ac5163-643c-4188-a95c-97aefd42aaf8_p1"> <start x="18026.75" y="3448.0"/> <end x="18027.125" y="3408.0"/> </arc> <arc class="production" id="prod_8bcabbb9-62fc-4341-a5fd-e555fc92b5fb" source="pr_77ac5163-643c-4188-a95c-97aefd42aaf8_p2" target="shh1_s_shh2_s37_shh1_shh2_sa31"> <start x="18027.125" y="3378.0"/> <end x="18027.5" y="3338.0"/> </arc> <arc class="catalysis" id="modif_d99c47e4-93b2-4731-90e4-6694b208980e" source="shh1_s651_shh1_shh2_sa32" target="pr_77ac5163-643c-4188-a95c-97aefd42aaf8"> <start x="18102.0" y="3393.0"/> <end x="18032.125" y="3393.0342"/> </arc> <arc class="consumption" id="cons_f8b3bbb8-76cd-4d32-8da3-d7a9df52bed3" source="shh1_s_shh2_s39_shh1_shh2_sa33" target="pr_cb4731f5-06d3-4ec9-aa89-022cc0d722eb_p1"> <start x="18757.0" y="3091.0"/> <end x="18783.5" y="3091.0"/> </arc> <arc class="production" id="prod_b2904ec8-f336-41ca-8ef3-8636db48a1a6" source="pr_cb4731f5-06d3-4ec9-aa89-022cc0d722eb_p2" target="shh1_s_shh2_s40_shh1_shh2_sa34"> <start x="18813.5" y="3091.0"/> <end x="18840.0" y="3091.0"/> </arc> <arc class="catalysis" id="modif_7f2a2626-e0e0-44a0-9790-e8d1b2645bb9" source="shh1_s_shh2_s337_shh1_shh2_csa5" target="pr_cb4731f5-06d3-4ec9-aa89-022cc0d722eb"> <start x="18566.0" y="3311.0"/> <end x="18793.5" y="3096.0"/> </arc> <arc class="consumption" id="cons_b0a234c0-cec3-4ce7-a9e1-f04675aba7dc" source="shh1_s_shh2_s40_shh1_shh2_sa34" target="pr_585c7cc4-a4ff-49c7-b711-3429c796d5a3_p1"> <start x="18930.0" y="3093.794"/> <end x="19018.5" y="3116.9268"/> </arc> <arc class="production" id="prod_6df53645-a915-4741-95d2-809f79b1cd59" source="pr_585c7cc4-a4ff-49c7-b711-3429c796d5a3_p2" target="shh1_s_shh2_s41_shh1_shh2_sa35"> <start x="19048.5" y="3116.9268"/> <end x="19137.0" y="3140.0598"/> </arc> <arc class="consumption" id="cons_a275c8e3-2836-4d32-a4ca-d3b050342371" source="shh1_s_shh2_s108_shh1_shh2_sa36" target="pr_d7c2657c-f269-453d-974b-3159e744b854_p1"> <start x="19375.5" y="3031.1802"/> <next x="19482.5" y="3029.5"/> <end x="19481.488" y="3171.75"/> </arc> <arc class="consumption" id="cons_62940211-60b2-4770-b19d-3245cf891df5" source="shh1_s_shh2_s14_shh1_shh2_sa37" target="pr_d7c2657c-f269-453d-974b-3159e744b854_p1"> <start x="19556.5" y="3021.1802"/> <next x="19482.5" y="3029.5"/> <end x="19481.488" y="3171.75"/> </arc> <arc class="production" id="prod_b1ccb11b-4eb6-452e-8e26-3ac2393a2fa3" source="pr_d7c2657c-f269-453d-974b-3159e744b854_p2" target="shh1_s_shh2_s43_shh1_shh2_csa6"> <start x="19481.488" y="3201.75"/> <end x="19480.5" y="3340.0"/> </arc> <arc class="consumption" id="cons_ac77cbdc-3a16-4abb-85fc-ec16d747201a" source="shh1_s_shh2_s48_shh1_shh2_sa42" target="pr_5721ab0b-316a-404b-8473-5c2679686acd_p1"> <start x="18757.0" y="3183.0"/> <end x="18783.5" y="3183.0"/> </arc> <arc class="production" id="prod_77f64714-0b17-485c-bb9b-0d6978abfcac" source="pr_5721ab0b-316a-404b-8473-5c2679686acd_p2" target="shh1_s_shh2_s49_shh1_shh2_sa43"> <start x="18813.5" y="3183.0"/> <end x="18840.0" y="3183.0"/> </arc> <arc class="catalysis" id="modif_29d7dc36-54c7-4c64-908a-5185e7ba6e74" source="shh1_s_shh2_s43_shh1_shh2_csa6" target="pr_5721ab0b-316a-404b-8473-5c2679686acd"> <start x="19381.0" y="3398.5"/> <end x="18798.5" y="3188.0"/> </arc> <arc class="consumption" id="cons_8bfc36ec-25e0-4d30-a5f2-cb9a7fa6ba1b" source="shh1_s_shh2_s46_shh1_shh2_sa40" target="pr_3fb9deed-ec0f-4ada-a0a3-2aa8d42b4e6c_p1"> <start x="18757.0" y="3137.0"/> <end x="18783.5" y="3137.0"/> </arc> <arc class="production" id="prod_8aea3482-ebe2-4690-bd32-09731004a738" source="pr_3fb9deed-ec0f-4ada-a0a3-2aa8d42b4e6c_p2" target="shh1_s_shh2_s47_shh1_shh2_sa41"> <start x="18813.5" y="3137.0"/> <end x="18840.0" y="3137.0"/> </arc> <arc class="catalysis" id="modif_95b16f44-133c-42fb-a724-b0ceda28e4f4" source="shh1_s_shh2_s43_shh1_shh2_csa6" target="pr_3fb9deed-ec0f-4ada-a0a3-2aa8d42b4e6c"> <start x="19381.0" y="3398.5"/> <end x="18793.5" y="3142.0"/> </arc> <arc class="consumption" id="cons_e644b401-3d92-4d37-a550-3564866c0faa" source="shh1_s_shh2_s47_shh1_shh2_sa41" target="pr_dd534be1-7fb8-4022-8ffb-e5e0d073b0e8_p1"> <start x="18930.0" y="3140.998"/> <end x="19018.5" y="3174.102"/> </arc> <arc class="production" id="prod_36abb662-6cc1-4dae-96a5-cfa857998f76" source="pr_dd534be1-7fb8-4022-8ffb-e5e0d073b0e8_p2" target="shh1_s_shh2_s50_shh1_shh2_sa44"> <start x="19048.5" y="3174.102"/> <end x="19137.0" y="3207.206"/> </arc> <arc class="consumption" id="cons_369a1d3a-f444-48ba-b4c1-0f9a31fd4702" source="shh1_s_shh2_s51_shh1_shh2_sa45" target="pr_17fcf11f-0c70-44f7-90d7-bfcd07c19854_p1"> <start x="18757.0" y="3229.0"/> <end x="18783.5" y="3229.0"/> </arc> <arc class="production" id="prod_21c41ab3-78e1-4052-9a5a-611ca03b0f2c" source="pr_17fcf11f-0c70-44f7-90d7-bfcd07c19854_p2" target="shh1_s_shh2_s52_shh1_shh2_sa46"> <start x="18813.5" y="3229.0"/> <end x="18840.0" y="3229.0"/> </arc> <arc class="catalysis" id="modif_66cae27b-073a-4253-8430-8816b7fb3505" source="shh1_s_shh2_s43_shh1_shh2_csa6" target="pr_17fcf11f-0c70-44f7-90d7-bfcd07c19854"> <start x="19381.0" y="3398.5"/> <end x="18798.5" y="3224.0"/> </arc> <arc class="catalysis" id="modif_7e104d12-45da-4324-9202-a1c362cea6e0" source="shh1_s_shh2_s337_shh1_shh2_csa5" target="pr_17fcf11f-0c70-44f7-90d7-bfcd07c19854"> <start x="18566.0" y="3311.0"/> <end x="18793.5" y="3224.0"/> </arc> <arc class="catalysis" id="modif_95b2ce7b-8130-42ee-9b80-6755d7722428" source="shh1_s_shh2_s338_shh1_shh2_csa16" target="pr_17fcf11f-0c70-44f7-90d7-bfcd07c19854"> <start x="18651.0" y="4204.5"/> <end x="18793.5" y="3234.0"/> </arc> <arc class="catalysis" id="modif_551ef3d1-69c4-4840-b7ef-3cf76e9acf32" source="shh1_s_shh2_s158_shh1_shh2_csa15" target="pr_17fcf11f-0c70-44f7-90d7-bfcd07c19854"> <start x="18656.5" y="4387.0"/> <end x="18803.5" y="3234.0"/> </arc> <arc class="consumption" id="cons_cf0ae82c-21d4-4e83-91e0-92ee62040cea" source="shh1_s_shh2_s52_shh1_shh2_sa46" target="pr_cd348cee-932a-4ddd-9a52-b79fd575ce04_p1"> <start x="18930.0" y="3225.1465"/> <end x="19018.5" y="3193.2388"/> </arc> <arc class="production" id="prod_f50016ad-ad34-4306-b627-e5a6fb2bdd8d" source="pr_cd348cee-932a-4ddd-9a52-b79fd575ce04_p2" target="shh1_s_shh2_s41_shh1_shh2_sa35"> <start x="19048.5" y="3193.2388"/> <end x="19137.0" y="3161.3313"/> </arc> <arc class="consumption" id="cons_1e748889-6747-4fb6-95dc-75989b9fb289" source="shh1_s_shh2_s49_shh1_shh2_sa43" target="pr_3ffff867-b419-4712-8d86-0a8bb2aa363e_p1"> <start x="18930.0" y="3188.0095"/> <end x="19019.785" y="3230.005"/> </arc> <arc class="production" id="prod_1b64894d-3399-4afd-9991-84efd4d496f1" source="pr_3ffff867-b419-4712-8d86-0a8bb2aa363e_p2" target="shh1_s_shh2_s53_shh1_shh2_sa47"> <start x="19049.785" y="3230.005"/> <end x="19139.572" y="3272.0"/> </arc> <arc class="consumption" id="cons_2d1ea0ff-b5ec-469e-bfb3-008302879df8" source="shh1_s_shh2_s54_shh1_shh2_sa48" target="pr_fc51d563-79bd-4007-a686-bd032dcf7ca4_p1"> <start x="18757.0" y="3277.0"/> <end x="18783.5" y="3277.0"/> </arc> <arc class="production" id="prod_548e5cce-2a5c-4b7e-8e9e-d6659c6a1521" source="pr_fc51d563-79bd-4007-a686-bd032dcf7ca4_p2" target="shh1_s_shh2_s55_shh1_shh2_sa49"> <start x="18813.5" y="3277.0"/> <end x="18840.0" y="3277.0"/> </arc> <arc class="catalysis" id="modif_1a477115-95f5-4dc3-b04f-e470b489e246" source="shh1_s_shh2_s43_shh1_shh2_csa6" target="pr_fc51d563-79bd-4007-a686-bd032dcf7ca4"> <start x="19381.0" y="3398.5"/> <end x="18798.5" y="3272.0"/> </arc> <arc class="consumption" id="cons_e41d13b0-85d3-4fb6-bf23-ff71f3f61f56" source="shh1_s_shh2_s55_shh1_shh2_sa49" target="pr_12a16bae-bbc3-420f-bc95-68815c0c8a2f_p1"> <start x="18930.0" y="3270.8342"/> <end x="19023.295" y="3217.417"/> </arc> <arc class="production" id="prod_8267cc2b-989c-4ebe-9865-9582698446c1" source="pr_12a16bae-bbc3-420f-bc95-68815c0c8a2f_p2" target="shh1_s_shh2_s41_shh1_shh2_sa35"> <start x="19053.295" y="3217.417"/> <end x="19146.59" y="3164.0"/> </arc> <arc class="consumption" id="cons_23b44348-1b01-444c-be5c-feda9d09349f" source="shh1_s_shh2_s55_shh1_shh2_sa49" target="pr_ef21a96d-f408-4fb6-b2f6-fe1e8529fd07_p1"> <start x="18930.0" y="3274.2544"/> <end x="19018.5" y="3251.5203"/> </arc> <arc class="production" id="prod_5c25118d-c52b-4c15-9796-03c503b6a08e" source="pr_ef21a96d-f408-4fb6-b2f6-fe1e8529fd07_p2" target="shh1_s_shh2_s50_shh1_shh2_sa44"> <start x="19048.5" y="3251.5203"/> <end x="19137.0" y="3228.7861"/> </arc> <arc class="consumption" id="cons_81892d6e-564b-4cd8-861e-bc563e02dbdf" source="shh1_s_shh2_s56_shh1_shh2_sa50" target="pr_4d05b5b3-d0ca-46e5-b3fb-f2c90a3c5723_p1"> <start x="18758.0" y="3413.0"/> <end x="18784.5" y="3412.5654"/> </arc> <arc class="production" id="prod_a26ebe7b-ae47-4417-8f12-2cccc2692d9f" source="pr_4d05b5b3-d0ca-46e5-b3fb-f2c90a3c5723_p2" target="shh1_s_shh2_s57_shh1_shh2_sa51"> <start x="18814.5" y="3412.5654"/> <end x="18841.0" y="3412.1309"/> </arc> <arc class="catalysis" id="modif_03a333fc-7b44-408e-b81f-c3b16931b7e8" source="shh1_s_shh2_s43_shh1_shh2_csa6" target="pr_4d05b5b3-d0ca-46e5-b3fb-f2c90a3c5723"> <start x="19381.0" y="3398.5"/> <end x="18799.447" y="3407.5657"/> </arc> <arc class="consumption" id="cons_bb4a142f-333e-4607-be7a-def27944ac90" source="shh1_s_shh2_s57_shh1_shh2_sa51" target="pr_ceaaa377-bec4-42e2-963b-21aae0efc1f3_p1"> <start x="18931.0" y="3405.9556"/> <end x="19023.49" y="3353.9778"/> </arc> <arc class="production" id="prod_164bd643-993a-4bba-a806-0bd7840d49e1" source="pr_ceaaa377-bec4-42e2-963b-21aae0efc1f3_p2" target="shh1_s_shh2_s53_shh1_shh2_sa47"> <start x="19053.49" y="3353.9778"/> <end x="19145.98" y="3302.0"/> </arc> <arc class="consumption" id="cons_ea632052-5100-49e0-a757-251938277797" source="shh1_s_shh2_s49_shh1_shh2_sa43" target="pr_79cccc99-38ee-4489-966b-e53dd9ba275c_p1"> <start x="18930.0" y="3181.3623"/> <end x="19018.5" y="3167.8018"/> </arc> <arc class="production" id="prod_97f11679-8c06-4230-b935-e93b37e9464c" source="pr_79cccc99-38ee-4489-966b-e53dd9ba275c_p2" target="shh1_s_shh2_s41_shh1_shh2_sa35"> <start x="19048.5" y="3167.8018"/> <end x="19137.0" y="3154.241"/> </arc> <arc class="consumption" id="cons_6b35d78a-1b79-42eb-bfe3-443e45f80cbc" source="shh1_s_shh2_s47_shh1_shh2_sa41" target="pr_9a424a26-f971-4dcd-8e58-63a1ecd1efcb_p1"> <start x="18930.0" y="3137.5781"/> <end x="19018.5" y="3142.3643"/> </arc> <arc class="production" id="prod_82616f7a-bcf5-4cb6-9e15-e3871e6a69c9" source="pr_9a424a26-f971-4dcd-8e58-63a1ecd1efcb_p2" target="shh1_s_shh2_s41_shh1_shh2_sa35"> <start x="19048.5" y="3142.3643"/> <end x="19137.0" y="3147.1504"/> </arc> <arc class="consumption" id="cons_d327349b-f076-44fa-94d7-fe3508e1d6a8" source="shh1_s_shh2_s58_shh1_shh2_sa52" target="pr_3939a690-1ab0-4a59-8257-7b9c67a8cbd0_p1"> <start x="18758.0" y="3458.0"/> <end x="18784.5" y="3458.0"/> </arc> <arc class="production" id="prod_db21d869-64fb-4ca4-92c9-6b310b95ee73" source="pr_3939a690-1ab0-4a59-8257-7b9c67a8cbd0_p2" target="shh1_s_shh2_s59_shh1_shh2_sa53"> <start x="18814.5" y="3458.0"/> <end x="18841.0" y="3458.0"/> </arc> <arc class="catalysis" id="modif_2dc8b661-aef8-4aa5-a91f-21ff90465501" source="shh1_s_shh2_s43_shh1_shh2_csa6" target="pr_3939a690-1ab0-4a59-8257-7b9c67a8cbd0"> <start x="19381.0" y="3398.5"/> <end x="18799.5" y="3453.0"/> </arc> <arc class="consumption" id="cons_f8d20e85-3d96-4302-9c71-7b3587082383" source="shh1_s_shh2_s59_shh1_shh2_sa53" target="pr_a54623af-1a1f-4b76-84cf-f88976da710f_p1"> <start x="18931.0" y="3446.4912"/> <end x="19030.854" y="3340.7456"/> </arc> <arc class="production" id="prod_f5133c7c-ff47-4b66-b80f-103b5f8a9efd" source="pr_a54623af-1a1f-4b76-84cf-f88976da710f_p2" target="shh1_s_shh2_s50_shh1_shh2_sa44"> <start x="19060.854" y="3340.7456"/> <end x="19160.707" y="3235.0"/> </arc> <arc class="consumption" id="cons_75fda366-e3d4-4bdb-8d4c-b47948205905" source="shh1_s_shh2_s60_shh1_shh2_sa54" target="pr_a241f06c-aab3-40d8-a890-2fc29f3a3a6d_p1"> <start x="18758.0" y="3505.0"/> <end x="18784.5" y="3505.0"/> </arc> <arc class="production" id="prod_5f146248-bdc3-4c18-8617-b815edd53894" source="pr_a241f06c-aab3-40d8-a890-2fc29f3a3a6d_p2" target="shh1_s_shh2_s61_shh1_shh2_sa55"> <start x="18814.5" y="3505.0"/> <end x="18841.0" y="3505.0"/> </arc> <arc class="catalysis" id="modif_fbac6127-fa50-41bb-83b9-cf5b6dbfde35" source="shh1_s_shh2_s43_shh1_shh2_csa6" target="pr_a241f06c-aab3-40d8-a890-2fc29f3a3a6d"> <start x="19381.0" y="3398.5"/> <end x="18799.5" y="3500.0"/> </arc> <arc class="consumption" id="cons_77725d03-c6ae-4c82-82e4-f674faf5bd41" source="shh1_s_shh2_s61_shh1_shh2_sa55" target="pr_1b9ceaa8-50b9-4785-9c40-fbbb685a1cc1_p1"> <start x="18931.0" y="3497.544"/> <end x="19025.426" y="3432.272"/> </arc> <arc class="production" id="prod_73fa9e79-30ee-4453-9199-93b68d6ee498" source="pr_1b9ceaa8-50b9-4785-9c40-fbbb685a1cc1_p2" target="shh1_s_shh2_s62_shh1_shh2_sa56"> <start x="19055.426" y="3432.272"/> <end x="19149.854" y="3367.0"/> </arc> <arc class="consumption" id="cons_09a96cb0-fda3-4c2e-92bb-ee8e9782b856" source="shh1_s_shh2_s63_shh1_shh2_sa57" target="pr_be6d1820-c91a-48e8-8c65-bf3edd03f080_p1"> <start x="18758.0" y="3548.0"/> <end x="18784.5" y="3548.0"/> </arc> <arc class="production" id="prod_b4aa7643-d907-4b23-85e4-e0bb05d72130" source="pr_be6d1820-c91a-48e8-8c65-bf3edd03f080_p2" target="shh1_s_shh2_s64_shh1_shh2_sa58"> <start x="18814.5" y="3548.0"/> <end x="18841.0" y="3548.0"/> </arc> <arc class="catalysis" id="modif_a27fb26f-eb60-43d9-ba96-e81cea9a43d2" source="shh1_s_shh2_s43_shh1_shh2_csa6" target="pr_be6d1820-c91a-48e8-8c65-bf3edd03f080"> <start x="19381.0" y="3398.5"/> <end x="18799.5" y="3543.0"/> </arc> <arc class="catalysis" id="modif_c0196400-8f14-4e84-8989-5a198e22035a" source="shh1_s_shh2_s338_shh1_shh2_csa16" target="pr_be6d1820-c91a-48e8-8c65-bf3edd03f080"> <start x="18651.0" y="4204.5"/> <end x="18794.5" y="3553.0"/> </arc> <arc class="catalysis" id="modif_2ede1a62-9da4-4cb9-95c4-17feba3496bd" source="shh1_s_shh2_s158_shh1_shh2_csa15" target="pr_be6d1820-c91a-48e8-8c65-bf3edd03f080"> <start x="18656.5" y="4387.0"/> <end x="18804.5" y="3553.0"/> </arc> <arc class="consumption" id="cons_dbc4e12b-8273-426e-88a3-b472ab7ccc7c" source="shh1_s_shh2_s64_shh1_shh2_sa58" target="pr_cf669126-88b7-4831-81f3-332c8fad4566_p1"> <start x="18931.0" y="3541.5671"/> <end x="19023.426" y="3486.2837"/> </arc> <arc class="production" id="prod_d2836650-dd97-4f34-a647-72a99e8c1be5" source="pr_cf669126-88b7-4831-81f3-332c8fad4566_p2" target="shh1_s_shh2_s65_shh1_shh2_sa59"> <start x="19053.426" y="3486.2837"/> <end x="19145.852" y="3431.0"/> </arc> <arc class="consumption" id="cons_e3387718-a8f3-43cb-bacd-32b2ec83d457" source="shh1_s_shh2_s66_shh1_shh2_sa60" target="pr_fa6376fb-4cc0-4aa7-b720-54d754bd0d09_p1"> <start x="18757.0" y="3325.0"/> <end x="18783.5" y="3325.0"/> </arc> <arc class="production" id="prod_cc04f9f7-a110-4152-b70e-655b548eb15c" source="pr_fa6376fb-4cc0-4aa7-b720-54d754bd0d09_p2" target="shh1_s_shh2_s67_shh1_shh2_sa61"> <start x="18813.5" y="3325.0"/> <end x="18840.0" y="3325.0"/> </arc> <arc class="catalysis" id="modif_f8252f89-0f97-40dc-a517-f9aa466dfd20" source="shh1_s_shh2_s43_shh1_shh2_csa6" target="pr_fa6376fb-4cc0-4aa7-b720-54d754bd0d09"> <start x="19381.0" y="3398.5"/> <end x="18798.5" y="3320.0"/> </arc> <arc class="consumption" id="cons_ff966fa1-31af-4aef-8bcc-c8f478690762" source="shh1_s_shh2_s67_shh1_shh2_sa61" target="pr_bd9b448e-3ba3-4154-87f1-2742f16d68b2_p1"> <start x="18930.0" y="3316.5222"/> <end x="19027.441" y="3240.2612"/> </arc> <arc class="production" id="prod_8fb200b1-c46f-4302-9b0b-8dd721114238" source="pr_bd9b448e-3ba3-4154-87f1-2742f16d68b2_p2" target="shh1_s_shh2_s41_shh1_shh2_sa35"> <start x="19057.441" y="3240.2612"/> <end x="19154.883" y="3164.0"/> </arc> <arc class="consumption" id="cons_7d9dbe3d-1aa7-4ce7-90c1-6b0c2e7671a7" source="shh1_s_shh2_s68_shh1_shh2_sa62" target="pr_1c1091a4-8dea-4994-92ea-63f49837e189_p1"> <start x="18757.0" y="3371.0"/> <end x="18783.5" y="3371.0"/> </arc> <arc class="production" id="prod_95e9ebc4-2a2a-4eca-9868-6bd9d5608328" source="pr_1c1091a4-8dea-4994-92ea-63f49837e189_p2" target="shh1_s_shh2_s69_shh1_shh2_sa63"> <start x="18813.5" y="3371.0"/> <end x="18840.0" y="3371.0"/> </arc> <arc class="catalysis" id="modif_8e6e4a61-2aea-4382-857a-7434b368c0ab" source="shh1_s_shh2_s43_shh1_shh2_csa6" target="pr_1c1091a4-8dea-4994-92ea-63f49837e189"> <start x="19381.0" y="3398.5"/> <end x="18798.5" y="3366.0"/> </arc> <arc class="consumption" id="cons_45330dc7-b29d-472d-b9c9-56724abb4dad" source="shh1_s_shh2_s69_shh1_shh2_sa63" target="pr_3983bca4-18b5-44f9-9652-92ff0d8c04e7_p1"> <start x="18930.0" y="3366.9539"/> <end x="19018.5" y="3333.451"/> </arc> <arc class="production" id="prod_7496106f-f6cb-406b-9fd5-cbf63739fee0" source="pr_3983bca4-18b5-44f9-9652-92ff0d8c04e7_p2" target="shh1_s_shh2_s53_shh1_shh2_sa47"> <start x="19048.5" y="3333.451"/> <end x="19137.0" y="3299.948"/> </arc> <arc class="consumption" id="cons_c662897b-f174-4374-8e17-8386b0577f8e" source="shh1_s_shh2_s70_shh1_shh2_sa64" target="pr_ed225e70-e6d7-4cc5-bcd3-40cb73407cd1_p1"> <start x="18758.0" y="3818.0"/> <end x="18784.5" y="3818.0"/> </arc> <arc class="production" id="prod_36febb50-04c5-49d5-b21b-83c69815419a" source="pr_ed225e70-e6d7-4cc5-bcd3-40cb73407cd1_p2" target="shh1_s_shh2_s71_shh1_shh2_sa65"> <start x="18814.5" y="3818.0"/> <end x="18841.0" y="3818.0"/> </arc> <arc class="catalysis" id="modif_e416cd1d-2b69-4e46-80bd-ffd4645f3022" source="shh1_s_shh2_s43_shh1_shh2_csa6" target="pr_ed225e70-e6d7-4cc5-bcd3-40cb73407cd1"> <start x="19381.0" y="3398.5"/> <end x="18804.5" y="3813.0"/> </arc> <arc class="catalysis" id="modif_70a4c3e7-1a42-435c-921f-9fff9eec70ea" source="shh1_s_shh2_s337_shh1_shh2_csa5" target="pr_ed225e70-e6d7-4cc5-bcd3-40cb73407cd1"> <start x="18566.0" y="3311.0"/> <end x="18794.5" y="3813.0"/> </arc> <arc class="inhibition" id="modif_7c274195-0b96-4a38-b219-46a71c713e5a" source="shh1_s_shh2_s336_shh1_shh2_csa2" target="pr_ed225e70-e6d7-4cc5-bcd3-40cb73407cd1"> <start x="18599.0" y="3173.0"/> <end x="18799.5" y="3813.0"/> </arc> <arc class="catalysis" id="modif_6cd3ede1-1059-420d-a997-ecebb769cd4f" source="shh1_s_shh2_s78_shh1_shh2_csa7" target="pr_ed225e70-e6d7-4cc5-bcd3-40cb73407cd1"> <start x="19551.0" y="3545.5"/> <end x="18799.5" y="3813.0"/> </arc> <arc class="catalysis" id="modif_e0e98ce0-58ca-447c-ae53-f78ea3caeb35" source="shh1_s_shh2_s338_shh1_shh2_csa16" target="pr_ed225e70-e6d7-4cc5-bcd3-40cb73407cd1"> <start x="18651.0" y="4204.5"/> <end x="18794.5" y="3823.0"/> </arc> <arc class="catalysis" id="modif_659e52d5-1817-4dfb-b4fa-f564b6b4fc7f" source="shh1_s_shh2_s158_shh1_shh2_csa15" target="pr_ed225e70-e6d7-4cc5-bcd3-40cb73407cd1"> <start x="18656.5" y="4387.0"/> <end x="18804.5" y="3823.0"/> </arc> <arc class="consumption" id="cons_ed689d9f-b02c-4be0-9d68-e184e4a89918" source="shh1_s_shh2_s72_shh1_shh2_sa66" target="pr_b37917f4-209d-42f0-82c1-dba836d58c56_p1"> <start x="18758.0" y="3599.0"/> <end x="18784.5" y="3599.0"/> </arc> <arc class="production" id="prod_ac8d2942-e83b-47c2-9cbb-b1da747a6636" source="pr_b37917f4-209d-42f0-82c1-dba836d58c56_p2" target="shh1_s_shh2_s73_shh1_shh2_sa67"> <start x="18814.5" y="3599.0"/> <end x="18841.0" y="3599.0"/> </arc> <arc class="catalysis" id="modif_e7410bdf-2753-41c4-b0f6-eceff168fb55" source="shh1_s_shh2_s43_shh1_shh2_csa6" target="pr_b37917f4-209d-42f0-82c1-dba836d58c56"> <start x="19381.0" y="3398.5"/> <end x="18799.5" y="3594.0"/> </arc> <arc class="consumption" id="cons_1f5abe93-aaa0-42a3-aa1a-cab2a9aa97d1" source="shh1_s_shh2_s73_shh1_shh2_sa67" target="pr_00629119-cc70-4930-8532-1f542a9c6623_p1"> <start x="18928.857" y="3586.5"/> <end x="19046.715" y="3459.25"/> </arc> <arc class="production" id="prod_369f2f49-f3ee-4422-8b8b-d2880b2d79a3" source="pr_00629119-cc70-4930-8532-1f542a9c6623_p2" target="shh1_s_shh2_s53_shh1_shh2_sa47"> <start x="19046.715" y="3429.25"/> <end x="19164.572" y="3302.0"/> </arc> <arc class="consumption" id="cons_41cfdaa2-69e3-4566-9f59-64912c0b3714" source="shh1_s_shh2_s74_shh1_shh2_sa68" target="pr_fc788cec-4f68-4b24-9e5b-4701337d1463_p1"> <start x="18758.0" y="3647.0"/> <end x="18784.5" y="3647.0"/> </arc> <arc class="production" id="prod_7cfea31f-c943-4f35-8413-d92d2df93484" source="pr_fc788cec-4f68-4b24-9e5b-4701337d1463_p2" target="shh1_s_shh2_s75_shh1_shh2_sa69"> <start x="18814.5" y="3647.0"/> <end x="18841.0" y="3647.0"/> </arc> <arc class="catalysis" id="modif_4b74ffeb-2f89-4cc2-99ca-0fc8febcc262" source="shh1_s_shh2_s43_shh1_shh2_csa6" target="pr_fc788cec-4f68-4b24-9e5b-4701337d1463"> <start x="19381.0" y="3398.5"/> <end x="18799.5" y="3642.0"/> </arc> <arc class="catalysis" id="modif_e14b17ea-acdb-4ce5-8319-38723f46a279" source="shh1_s_shh2_s337_shh1_shh2_csa5" target="pr_fc788cec-4f68-4b24-9e5b-4701337d1463"> <start x="18566.0" y="3311.0"/> <end x="18794.5" y="3642.0"/> </arc> <arc class="inhibition" id="modif_d1954ecf-e553-42f6-808e-aa35b7833524" source="shh1_s_shh2_s336_shh1_shh2_csa2" target="pr_fc788cec-4f68-4b24-9e5b-4701337d1463"> <start x="18599.0" y="3173.0"/> <end x="18799.5" y="3642.0"/> </arc> <arc class="consumption" id="cons_a46306ad-8a51-42e2-9274-ab030a0480c8" source="shh1_s_shh2_s14_shh1_shh2_sa72" target="pr_ca0901ab-8a5f-4192-9afd-7cd73258a186_p1"> <start x="19861.5" y="3061.0"/> <next x="19861.5" y="3094.7805"/> <end x="19805.254" y="3307.1401"/> </arc> <arc class="consumption" id="cons_b0c2f06e-1c8a-4c03-853f-4446eb67fe80" source="shh1_s_shh2_s100_shh1_shh2_sa2" target="pr_ca0901ab-8a5f-4192-9afd-7cd73258a186_p1"> <start x="20010.375" y="3069.0"/> <next x="19861.5" y="3094.7805"/> <end x="19805.254" y="3307.1401"/> </arc> <arc class="production" id="prod_e3a9fc92-924a-410a-b5f0-df354d153a4a" source="pr_ca0901ab-8a5f-4192-9afd-7cd73258a186_p2" target="shh1_s_shh2_s78_shh1_shh2_csa7"> <start x="19805.254" y="3337.1401"/> <end x="19750.0" y="3545.5"/> </arc> <arc class="consumption" id="cons_555122cc-763d-4996-9797-ac0c10a94c23" source="shh1_s_shh2_s81_shh1_shh2_sa75" target="pr_3a50749e-5657-461a-b808-d63376260265_p1"> <start x="18758.0" y="3687.0"/> <end x="18784.5" y="3687.0"/> </arc> <arc class="production" id="prod_45ef238c-15f0-4862-a4d6-cbd530379c20" source="pr_3a50749e-5657-461a-b808-d63376260265_p2" target="shh1_s_shh2_s82_shh1_shh2_sa76"> <start x="18814.5" y="3687.0"/> <end x="18841.0" y="3687.0"/> </arc> <arc class="catalysis" id="modif_6441011f-95e3-4aac-841f-3ccd8b74302e" source="shh1_s_shh2_s43_shh1_shh2_csa6" target="pr_3a50749e-5657-461a-b808-d63376260265"> <start x="19381.0" y="3398.5"/> <end x="18799.5" y="3682.0"/> </arc> <arc class="consumption" id="cons_c896a13a-3e5c-468d-a90c-1cf7d52e740e" source="shh1_s_shh2_s82_shh1_shh2_sa76" target="pr_54cf600b-00a0-4d52-99d2-2e2c984fc914_p1"> <start x="18926.578" y="3674.5"/> <end x="19046.941" y="3503.25"/> </arc> <arc class="production" id="prod_570fe8da-2163-4e4f-a1b5-627a2c5f6d28" source="pr_54cf600b-00a0-4d52-99d2-2e2c984fc914_p2" target="shh1_s_shh2_s53_shh1_shh2_sa47"> <start x="19046.941" y="3473.25"/> <end x="19167.307" y="3302.0"/> </arc> <arc class="consumption" id="cons_3416d5d8-6b80-4d42-9f17-7824177068ec" source="shh1_s_shh2_s83_shh1_shh2_sa77" target="pr_22f9a157-79f2-4086-8952-ca8c8613bfc4_p1"> <start x="18758.0" y="3730.0"/> <end x="18784.5" y="3730.0"/> </arc> <arc class="production" id="prod_ea67f0b6-3f13-4627-93dd-c3be1524fae3" source="pr_22f9a157-79f2-4086-8952-ca8c8613bfc4_p2" target="shh1_s_shh2_s84_shh1_shh2_sa78"> <start x="18814.5" y="3730.0"/> <end x="18841.0" y="3730.0"/> </arc> <arc class="catalysis" id="modif_833817ce-9f88-4108-88b4-1b3983ab9ac2" source="shh1_s_shh2_s43_shh1_shh2_csa6" target="pr_22f9a157-79f2-4086-8952-ca8c8613bfc4"> <start x="19381.0" y="3398.5"/> <end x="18799.5" y="3725.0"/> </arc> <arc class="inhibition" id="modif_1efe8aaf-51cc-4ba9-b266-d12d58a6f231" source="shh1_s_shh2_s336_shh1_shh2_csa2" target="pr_22f9a157-79f2-4086-8952-ca8c8613bfc4"> <start x="18599.0" y="3173.0"/> <end x="18794.5" y="3725.0"/> </arc> <arc class="inhibition" id="modif_ad9b523a-1c8f-4e67-a91a-2e61e686df9d" source="shh1_s670_shh1_shh2_csa21" target="pr_22f9a157-79f2-4086-8952-ca8c8613bfc4"> <start x="19251.0" y="3551.5"/> <end x="18804.5" y="3725.0"/> </arc> <arc class="consumption" id="cons_c162c611-289c-4a50-a76e-d88797487080" source="shh1_s_shh2_s85_shh1_shh2_sa79" target="pr_fa135382-5def-44f9-9c8a-6dafb9c88aba_p1"> <start x="18758.0" y="3772.0"/> <end x="18784.5" y="3772.0"/> </arc> <arc class="production" id="prod_a4ea4a2b-6f32-43be-9494-5d378d1eea74" source="pr_fa135382-5def-44f9-9c8a-6dafb9c88aba_p2" target="shh1_s_shh2_s86_shh1_shh2_sa80"> <start x="18814.5" y="3772.0"/> <end x="18841.0" y="3772.0"/> </arc> <arc class="inhibition" id="modif_86139a0e-44d6-4fe4-8576-926f7901906b" source="shh1_s_shh2_s336_shh1_shh2_csa2" target="pr_fa135382-5def-44f9-9c8a-6dafb9c88aba"> <start x="18599.0" y="3173.0"/> <end x="18794.5" y="3767.0"/> </arc> <arc class="consumption" id="cons_3464ce4a-0c9c-45c4-abff-9731bcb890db" source="shh1_s_shh2_s88_shh1_shh2_sa82" target="pr_00e4552d-14ae-4835-ac7b-8685d7cae2a2_p1"> <start x="18758.0" y="3863.0"/> <end x="18784.5" y="3863.0"/> </arc> <arc class="production" id="prod_c01783f2-55bf-41c1-b6ee-c783e7b9b547" source="pr_00e4552d-14ae-4835-ac7b-8685d7cae2a2_p2" target="shh1_s_shh2_s89_shh1_shh2_sa83"> <start x="18814.5" y="3863.0"/> <end x="18841.0" y="3863.0"/> </arc> <arc class="catalysis" id="modif_add2131a-e147-4ec8-813a-ab33a0f4203d" source="shh1_s_shh2_s337_shh1_shh2_csa5" target="pr_00e4552d-14ae-4835-ac7b-8685d7cae2a2"> <start x="18566.0" y="3311.0"/> <end x="18799.5" y="3858.0"/> </arc> <arc class="consumption" id="cons_5f910138-7692-44d7-9eb2-852a25d3bb98" source="shh1_s_shh2_s89_shh1_shh2_sa83" target="pr_66fc2ac7-3e30-475f-b807-35f60f8fbd5b_p1"> <start x="18924.775" y="3850.5"/> <end x="19046.123" y="3623.75"/> </arc> <arc class="production" id="prod_c57cd172-c846-4fc6-b3be-0fbc156a6fcf" source="pr_66fc2ac7-3e30-475f-b807-35f60f8fbd5b_p2" target="shh1_s_shh2_s62_shh1_shh2_sa56"> <start x="19046.123" y="3593.75"/> <end x="19167.47" y="3367.0"/> </arc> <arc class="consumption" id="cons_c65c1f24-202b-467b-9c78-0fb69b15c966" source="shh1_s_shh2_s90_shh1_shh2_sa84" target="pr_e684bd6f-3151-450a-83cd-d6e98b5498eb_p1"> <start x="18758.0" y="3944.0"/> <end x="18784.5" y="3944.0"/> </arc> <arc class="production" id="prod_26416b14-424d-4347-ba39-830af315f24c" source="pr_e684bd6f-3151-450a-83cd-d6e98b5498eb_p2" target="shh1_s_shh2_s91_shh1_shh2_sa85"> <start x="18814.5" y="3944.0"/> <end x="18841.0" y="3944.0"/> </arc> <arc class="catalysis" id="modif_22e6ee7f-5cda-4105-b9be-0e07dc92cc1d" source="shh1_s_shh2_s337_shh1_shh2_csa5" target="pr_e684bd6f-3151-450a-83cd-d6e98b5498eb"> <start x="18566.0" y="3311.0"/> <end x="18799.5" y="3939.0"/> </arc> <arc class="consumption" id="cons_3580c153-da4e-4138-83f0-d1cbcd864b31" source="shh1_s_shh2_s91_shh1_shh2_sa85" target="pr_30bc61c4-9547-47b8-909f-fc22a66b0d03_p1"> <start x="18923.418" y="3931.5"/> <end x="19047.258" y="3631.75"/> </arc> <arc class="production" id="prod_319c3ead-820c-4abb-9050-0c265abb5c5e" source="pr_30bc61c4-9547-47b8-909f-fc22a66b0d03_p2" target="shh1_s_shh2_s53_shh1_shh2_sa47"> <start x="19047.258" y="3601.75"/> <end x="19171.098" y="3302.0"/> </arc> <arc class="consumption" id="cons_3d1488f3-f527-4648-ac10-47f978817fc9" source="shh1_s_shh2_s92_shh1_shh2_sa86" target="pr_f02bc800-3687-49e0-a5d4-5bd9c1731b58_p1"> <start x="18758.0" y="3984.0"/> <end x="18784.5" y="3984.0"/> </arc> <arc class="production" id="prod_bc64fbdc-b6c6-4155-a9fa-0165b3ef6010" source="pr_f02bc800-3687-49e0-a5d4-5bd9c1731b58_p2" target="shh1_s_shh2_s93_shh1_shh2_sa87"> <start x="18814.5" y="3984.0"/> <end x="18841.0" y="3984.0"/> </arc> <arc class="catalysis" id="modif_5dc6ddab-a00c-451c-83b9-248816cc9aef" source="shh1_s_shh2_s337_shh1_shh2_csa5" target="pr_f02bc800-3687-49e0-a5d4-5bd9c1731b58"> <start x="18566.0" y="3311.0"/> <end x="18799.5" y="3979.0"/> </arc> <arc class="consumption" id="cons_5b61930d-39ce-478b-8ee1-0a82df0e84b4" source="shh1_s_shh2_s94_shh1_shh2_sa88" target="pr_57864db1-a469-4b72-85f4-cba8e1f6a144_p1"> <start x="18758.0" y="4028.0"/> <end x="18784.5" y="4028.0"/> </arc> <arc class="production" id="prod_2b9adc9a-d54e-481f-b129-c3ee3bcf245a" source="pr_57864db1-a469-4b72-85f4-cba8e1f6a144_p2" target="shh1_s_shh2_s95_shh1_shh2_sa89"> <start x="18814.5" y="4028.0"/> <end x="18841.0" y="4028.0"/> </arc> <arc class="catalysis" id="modif_98b2decf-b5c1-475a-a4cf-7148b4294e45" source="shh1_s_shh2_s337_shh1_shh2_csa5" target="pr_57864db1-a469-4b72-85f4-cba8e1f6a144"> <start x="18566.0" y="3311.0"/> <end x="18794.5" y="4023.0"/> </arc> <arc class="catalysis" id="modif_71f75ef8-b71e-4199-bbbf-c4ef54b50a23" source="shh1_s_shh2_s43_shh1_shh2_csa6" target="pr_57864db1-a469-4b72-85f4-cba8e1f6a144"> <start x="19381.0" y="3398.5"/> <end x="18804.5" y="4023.0"/> </arc> <arc class="consumption" id="cons_ce294b53-eaa9-4855-9a05-6afcba68db28" source="shh1_s_shh2_s93_shh1_shh2_sa87" target="pr_cbe3b30f-89be-4b12-a7b1-82b1d632f211_p1"> <start x="18923.137" y="3971.5"/> <end x="19047.287" y="3651.75"/> </arc> <arc class="production" id="prod_6f840e3e-c0bd-4607-b0d0-786063d759ff" source="pr_cbe3b30f-89be-4b12-a7b1-82b1d632f211_p2" target="shh1_s_shh2_s53_shh1_shh2_sa47"> <start x="19047.287" y="3621.75"/> <end x="19171.438" y="3302.0"/> </arc> <arc class="consumption" id="cons_b4b8f93c-76ef-454e-a995-231dd2ac0dfc" source="shh1_s_shh2_s95_shh1_shh2_sa89" target="pr_eeabdae2-2aaa-413a-86a6-9937cd5596c2_p1"> <start x="18924.34" y="4015.5"/> <end x="19046.166" y="3769.75"/> </arc> <arc class="production" id="prod_84aa3b3f-b9d3-44fa-8828-57345bcb445d" source="pr_eeabdae2-2aaa-413a-86a6-9937cd5596c2_p2" target="shh1_s_shh2_s96_shh1_shh2_sa90"> <start x="19046.166" y="3739.75"/> <end x="19167.992" y="3494.0"/> </arc> <arc class="consumption" id="cons_407ce3ef-a169-4e12-b610-b3a5e5b1deed" source="shh1_s_shh2_s22_shh1_shh2_sa21" target="pr_2f791b08-d7a1-4958-9378-1084bb238ca6_p1"> <start x="18355.375" y="3468.0"/> <end x="18428.562" y="3516.0"/> </arc> <arc class="production" id="prod_3dbed588-460f-4400-baea-e6b003a95bef" source="pr_2f791b08-d7a1-4958-9378-1084bb238ca6_p2" target="shh1_s_shh2_s101_shh1_shh2_sa91"> <start x="18458.562" y="3516.0"/> <end x="18531.75" y="3564.0"/> </arc> <arc class="catalysis" id="modif_67dbafc6-0c46-4e33-95d8-78a6075fadff" source="shh1_s_shh2_s102_shh1_shh2_sa92" target="pr_2f791b08-d7a1-4958-9378-1084bb238ca6"> <start x="18516.0" y="3486.397"/> <end x="18445.953" y="3511.6084"/> </arc> <arc class="consumption" id="cons_86df99fe-631d-4c40-b44e-247cec63f230" source="shh1_s_shh2_s103_shh1_shh2_sa93" target="pr_37bbeab5-77ef-4039-b190-b930f27e6573_p1"> <start x="18451.0" y="3584.0"/> <next x="18519.0" y="3608.0"/> <end x="18519.0" y="3616.0"/> </arc> <arc class="consumption" id="cons_4fd3d442-1a15-464d-b870-bd228f755bbc" source="shh1_s_shh2_s101_shh1_shh2_sa91" target="pr_37bbeab5-77ef-4039-b190-b930f27e6573_p1"> <start x="18571.75" y="3584.0"/> <next x="18519.0" y="3608.0"/> <end x="18519.0" y="3616.0"/> </arc> <arc class="production" id="prod_ac54622d-3722-4e9b-b3a1-6be6c3dc0570" source="pr_37bbeab5-77ef-4039-b190-b930f27e6573_p2" target="shh1_s_shh2_s104_shh1_shh2_csa8"> <start x="18519.0" y="3646.0"/> <end x="18519.0" y="3650.0"/> </arc> <arc class="consumption" id="cons_2648d9e3-55dd-443d-a524-a91effdaa809" source="shh1_s_shh2_s108_shh1_shh2_sa36" target="pr_5bb3e7d5-ed23-486f-90cb-72c51488fd88_p1"> <start x="19404.377" y="3053.6802"/> <end x="19471.438" y="3117.62"/> </arc> <arc class="production" id="prod_46733001-3abb-411b-8cc5-7bde48d740eb" source="pr_5bb3e7d5-ed23-486f-90cb-72c51488fd88_p2" target="shh1_s_shh2_s107_shh1_shh2_sa96"> <start x="19501.438" y="3117.62"/> <end x="19568.5" y="3181.56"/> </arc> <arc class="catalysis" id="modif_5a8e7391-9f17-44f0-9d58-c1b081f4b4f0" source="shh1_s_shh2_s102_shh1_shh2_sa92" target="pr_5bb3e7d5-ed23-486f-90cb-72c51488fd88"> <start x="18596.0" y="3472.0"/> <end x="19483.365" y="3121.5642"/> </arc> <arc class="consumption" id="cons_9ff58bf0-b9a4-4f9f-b2b3-03f253ebb773" source="shh1_s_shh2_s100_shh1_shh2_sa2" target="pr_7bd44eb4-9972-4ecb-a33a-5daf916a2850_p1"> <start x="20010.375" y="3069.0"/> <end x="19964.312" y="3254.3574"/> </arc> <arc class="production" id="prod_68518167-af98-4c10-9d23-2cf30c9d11cb" source="pr_7bd44eb4-9972-4ecb-a33a-5daf916a2850_p2" target="shh1_s_shh2_s109_shh1_shh2_sa98"> <start x="19964.312" y="3284.3574"/> <end x="19918.25" y="3469.715"/> </arc> <arc class="catalysis" id="modif_43bb2dd6-9fd5-4ab9-9bdf-bb03470a9a2d" source="shh1_s_shh2_s102_shh1_shh2_sa92" target="pr_7bd44eb4-9972-4ecb-a33a-5daf916a2850"> <start x="18596.0" y="3472.0"/> <end x="19959.44" y="3268.237"/> </arc> <arc class="consumption" id="cons_73a3e14c-1dbf-415a-950e-71ab49c46b14" source="shh1_s_shh2_s107_shh1_shh2_sa96" target="pr_2f3ce3ad-edd5-4ea9-82db-e4afa1a32bc6_p1"> <start x="19568.5" y="3204.06"/> <next x="19790.5" y="3695.2085"/> <end x="19780.332" y="3728.7292"/> </arc> <arc class="consumption" id="cons_155b2172-992d-4d09-baca-caa7775861c6" source="shh1_s_shh2_s103_shh1_shh2_sa97" target="pr_2f3ce3ad-edd5-4ea9-82db-e4afa1a32bc6_p1"> <start x="19830.5" y="3784.25"/> <next x="19790.5" y="3695.2085"/> <end x="19780.332" y="3728.7292"/> </arc> <arc class="production" id="prod_f9e4baad-3c18-4bd6-b8b2-3832393bb101" source="pr_2f3ce3ad-edd5-4ea9-82db-e4afa1a32bc6_p2" target="shh1_s_shh2_s110_shh1_shh2_csa9"> <start x="19780.332" y="3758.7292"/> <end x="19771.0" y="3788.25"/> </arc> <arc class="consumption" id="cons_04a4d144-93ac-415d-befc-13e0d30ec2cb" source="shh1_s_shh2_s103_shh1_shh2_sa97" target="pr_d2f5e71e-4661-49db-b700-b146093ae2ed_p1"> <start x="19910.5" y="3784.25"/> <next x="19938.25" y="3711.2478"/> <end x="19969.5" y="3751.489"/> </arc> <arc class="consumption" id="cons_dc42283d-7800-4a04-a423-a0403b3ad3d9" source="shh1_s_shh2_s109_shh1_shh2_sa98" target="pr_d2f5e71e-4661-49db-b700-b146093ae2ed_p1"> <start x="19918.25" y="3490.215"/> <next x="19938.25" y="3711.2478"/> <end x="19969.5" y="3751.489"/> </arc> <arc class="production" id="prod_59493669-ae8d-4927-88c1-cba275b8ac4f" source="pr_d2f5e71e-4661-49db-b700-b146093ae2ed_p2" target="shh1_s_shh2_s113_shh1_shh2_csa10"> <start x="19999.5" y="3751.489"/> <end x="20026.75" y="3788.25"/> </arc> <arc class="consumption" id="cons_53ea4477-4d4b-425a-9e03-be2890fd687b" source="shh1_s_shh2_s22_shh1_shh2_sa21" target="pr_ebf43d24-9089-4b78-a675-0c298f842877_p1"> <start x="18295.375" y="3488.0"/> <end x="18294.875" y="3667.75"/> </arc> <arc class="production" id="prod_d0a0539b-7a49-45f2-83e4-2a509da9f84d" source="pr_ebf43d24-9089-4b78-a675-0c298f842877_p2" target="shh1_s_shh2_s116_shh1_shh2_sa103"> <start x="18294.875" y="3697.75"/> <end x="18294.375" y="3877.5"/> </arc> <arc class="catalysis" id="modif_e08f2ece-2680-4880-9003-cc89567d0def" source="shh1_s_shh2_s117_shh1_shh2_sa104" target="pr_ebf43d24-9089-4b78-a675-0c298f842877"> <start x="18419.033" y="3841.997"/> <end x="18299.875" y="3682.763"/> </arc> <arc class="consumption" id="cons_5727c82b-a6cf-4293-bb03-b0cb00ffdaea" source="shh1_s_shh2_s116_shh1_shh2_sa103" target="pr_2ecafbbc-3f16-42d6-bc5a-371c463d5def_p1"> <start x="18334.375" y="3877.5"/> <end x="18334.875" y="3697.75"/> </arc> <arc class="production" id="prod_66189028-5da3-4e20-a16c-f69859bb51e5" source="pr_2ecafbbc-3f16-42d6-bc5a-371c463d5def_p2" target="shh1_s_shh2_s22_shh1_shh2_sa21"> <start x="18334.875" y="3667.75"/> <end x="18335.375" y="3488.0"/> </arc> <arc class="catalysis" id="modif_fc3f7763-0b2d-446e-b973-1e9a1bde160a" source="shh1_s_shh2_s118_shh1_shh2_sa105" target="pr_2ecafbbc-3f16-42d6-bc5a-371c463d5def"> <start x="18523.0" y="3841.997"/> <end x="18339.875" y="3682.763"/> </arc> <arc class="consumption" id="cons_ac62cfbe-75cc-4d1c-9115-ada7701576c0" source="shh1_s_shh2_s118_shh1_shh2_sa105" target="pr_fe8fb01b-fed7-4b89-ad5b-bc6a8546cd28_p1"> <start x="18546.0" y="3881.997"/> <end x="18545.75" y="3926.9985"/> </arc> <arc class="production" id="prod_da88c5c4-b23b-4188-ae10-2f5d988cd984" source="pr_fe8fb01b-fed7-4b89-ad5b-bc6a8546cd28_p2" target="shh1_s_shh2_s122_shh1_shh2_sa106"> <start x="18545.75" y="3956.9985"/> <end x="18545.5" y="4002.0"/> </arc> <arc class="catalysis" id="logicarc_ed300280-8fce-4c10-8e0c-1bda7ecf7f59" source="logicglyph_35447194-2c1c-43ae-a985-5ac04d3e9277_p2" target="pr_fe8fb01b-fed7-4b89-ad5b-bc6a8546cd28"> <start x="18506.334" y="3947.0"/> <end x="18540.75" y="3941.9778"/> </arc> <arc class="catalysis" id="logicarc_bc30d3f5-4540-4c69-b290-9e6bd1168fd9" source="logicglyph_1a25e3f4-9c59-4cd4-840b-ef9a60f8a60c_p2" target="pr_fe8fb01b-fed7-4b89-ad5b-bc6a8546cd28"> <start x="18440.5" y="4036.25"/> <end x="18540.729" y="3946.9775"/> </arc> <arc class="logic arc" id="modif_e3399875-14a7-4e24-8362-d5f289f5b78d" source="shh1_s_shh2_s10_shh1_shh2_sa107" target="logicglyph_35447194-2c1c-43ae-a985-5ac04d3e9277_p1"> <start x="18462.0" y="3927.0"/> <end x="18466.334" y="3947.0"/> </arc> <arc class="logic arc" id="modif_3bca6020-c821-48a4-9f5f-1feb84a516b6" source="shh1_s_shh2_s11_shh1_shh2_sa108" target="logicglyph_35447194-2c1c-43ae-a985-5ac04d3e9277_p1"> <start x="18462.0" y="3975.0"/> <end x="18466.334" y="3947.0"/> </arc> <arc class="logic arc" id="modif_53b02602-6b90-4655-b78a-e7565694e4c7" source="shh1_s_shh2_s233_shh1_shh2_csa23" target="logicglyph_1a25e3f4-9c59-4cd4-840b-ef9a60f8a60c_p1"> <start x="18275.0" y="4062.0"/> <end x="18400.5" y="4036.25"/> </arc> <arc class="logic arc" id="modif_ce8da050-f6e6-449f-b779-466fc54559cf" source="shh1_s_shh2_s239_shh1_shh2_csa24" target="logicglyph_1a25e3f4-9c59-4cd4-840b-ef9a60f8a60c_p1"> <start x="18380.5" y="4062.0"/> <end x="18400.5" y="4036.25"/> </arc> <arc class="logic arc" id="modif_e7241849-74fe-499f-ad56-cfc2e882cc74" source="shh1_s_shh2_s119_shh1_shh2_csa11" target="logicglyph_1a25e3f4-9c59-4cd4-840b-ef9a60f8a60c_p1"> <start x="18486.0" y="4062.0"/> <end x="18400.5" y="4036.25"/> </arc> <arc class="consumption" id="cons_45bc14bf-6af2-499d-ada8-f21e2538597b" source="shh1_s_shh2_s108_shh1_shh2_sa36" target="pr_ccd988c1-c3df-4fa7-8dd8-27b79e20fb59_p1"> <start x="19334.25" y="3053.6802"/> <end x="19334.625" y="3099.34"/> </arc> <arc class="production" id="prod_8815aeda-5124-4ecb-955f-5f2e71545844" source="pr_ccd988c1-c3df-4fa7-8dd8-27b79e20fb59_p2" target="shh1_s_shh2_s124_shh1_shh2_sa112"> <start x="19334.625" y="3129.34"/> <end x="19335.0" y="3175.0"/> </arc> <arc class="catalysis" id="modif_e4474511-5668-4082-8863-93df5d776170" source="shh1_s_shh2_s117_shh1_shh2_sa104" target="pr_ccd988c1-c3df-4fa7-8dd8-27b79e20fb59"> <start x="18457.959" y="3841.997"/> <end x="19329.625" y="3114.371"/> </arc> <arc class="consumption" id="cons_fea9f4b8-58c8-4bcd-843f-4405034f157d" source="shh1_s_shh2_s124_shh1_shh2_sa112" target="pr_7fbd4b08-90dc-49e8-894c-e19b60ee7842_p1"> <start x="19376.25" y="3175.0"/> <end x="19375.875" y="3129.34"/> </arc> <arc class="production" id="prod_cb757036-ad92-4886-8607-e6629b5d10b6" source="pr_7fbd4b08-90dc-49e8-894c-e19b60ee7842_p2" target="shh1_s_shh2_s108_shh1_shh2_sa36"> <start x="19375.875" y="3099.34"/> <end x="19375.5" y="3053.6802"/> </arc> <arc class="catalysis" id="modif_bfcf451c-0c8d-4e8e-aa39-af5afbea4e00" source="shh1_s_shh2_s118_shh1_shh2_sa105" target="pr_7fbd4b08-90dc-49e8-894c-e19b60ee7842"> <start x="18568.066" y="3841.997"/> <end x="19370.875" y="3114.371"/> </arc> <arc class="consumption" id="cons_b9de7fe8-7fc4-4ea6-ba0f-100671600d9c" source="shh1_s_shh2_s125_shh1_shh2_sa113" target="pr_9e014253-19c0-4e54-8474-5b81dca59c45_p1"> <start x="18769.0" y="4072.0"/> <end x="18790.0" y="4070.722"/> </arc> <arc class="production" id="prod_49532fe6-e05f-4bc7-b44c-ec3f43d86aba" source="pr_9e014253-19c0-4e54-8474-5b81dca59c45_p2" target="shh1_s_shh2_s126_shh1_shh2_sa114"> <start x="18820.0" y="4070.722"/> <end x="18841.0" y="4069.4438"/> </arc> <arc class="catalysis" id="modif_5d3e6f26-7458-4667-a835-21bca54d3d28" source="shh1_s_shh2_s337_shh1_shh2_csa5" target="pr_9e014253-19c0-4e54-8474-5b81dca59c45"> <start x="18566.0" y="3311.0"/> <end x="18799.826" y="4065.9026"/> </arc> <arc class="catalysis" id="modif_f3cc668e-9a05-4dab-8f1b-a2a5444132c9" source="shh1_s_shh2_s43_shh1_shh2_csa6" target="pr_9e014253-19c0-4e54-8474-5b81dca59c45"> <start x="19381.0" y="3398.5"/> <end x="18809.82" y="4065.5476"/> </arc> <arc class="consumption" id="cons_9ccf3183-e263-4e21-8d36-df3e9b7fd7a2" source="shh1_s_shh2_s127_shh1_shh2_sa115" target="pr_bebdb41f-0bdd-4bc3-b187-39f39497b11b_p1"> <start x="18758.0" y="4112.0"/> <end x="18784.5" y="4112.0"/> </arc> <arc class="production" id="prod_388dc29e-5888-484b-a9f8-9ca4f914d1be" source="pr_bebdb41f-0bdd-4bc3-b187-39f39497b11b_p2" target="shh1_s_shh2_s128_shh1_shh2_sa116"> <start x="18814.5" y="4112.0"/> <end x="18841.0" y="4112.0"/> </arc> <arc class="catalysis" id="modif_b905284f-f5f3-4561-84c7-8499381881df" source="shh1_s_shh2_s337_shh1_shh2_csa5" target="pr_bebdb41f-0bdd-4bc3-b187-39f39497b11b"> <start x="18566.0" y="3311.0"/> <end x="18794.5" y="4107.0"/> </arc> <arc class="catalysis" id="modif_207b9141-7655-494e-8a52-69a52a63f76a" source="shh1_s_shh2_s43_shh1_shh2_csa6" target="pr_bebdb41f-0bdd-4bc3-b187-39f39497b11b"> <start x="19381.0" y="3398.5"/> <end x="18804.5" y="4107.0"/> </arc> <arc class="inhibition" id="modif_d5b8ee40-e456-4542-a5c1-5a128492a233" source="shh1_s_shh2_s336_shh1_shh2_csa2" target="pr_bebdb41f-0bdd-4bc3-b187-39f39497b11b"> <start x="18599.0" y="3173.0"/> <end x="18799.5" y="4107.0"/> </arc> <arc class="consumption" id="cons_89492c26-2c71-410c-af7b-3e7de003c08b" source="shh1_s_shh2_s128_shh1_shh2_sa116" target="pr_7ec0575b-865d-438c-8adc-9225ee0ac34e_p1"> <start x="18922.416" y="4099.5"/> <end x="19047.36" y="3715.75"/> </arc> <arc class="production" id="prod_7c8fc51d-c2b7-43fc-8d11-fe9774001fd6" source="pr_7ec0575b-865d-438c-8adc-9225ee0ac34e_p2" target="shh1_s_shh2_s53_shh1_shh2_sa47"> <start x="19047.36" y="3685.75"/> <end x="19172.3" y="3302.0"/> </arc> <arc class="consumption" id="cons_2db929c5-6d3a-4e68-b4ad-b2a3f26eb8f2" source="shh1_s_shh2_s71_shh1_shh2_sa65" target="pr_0eeb9b4c-99be-4840-9a18-12a4e665d7ee_p1"> <start x="18924.586" y="3805.5"/> <end x="19047.14" y="3568.75"/> </arc> <arc class="production" id="prod_d802cb4a-6cba-4378-b124-1888ba89b65c" source="pr_0eeb9b4c-99be-4840-9a18-12a4e665d7ee_p2" target="shh1_s_shh2_s53_shh1_shh2_sa47"> <start x="19047.14" y="3538.75"/> <end x="19169.697" y="3302.0"/> </arc> <arc class="consumption" id="cons_5241e141-c77b-46bb-9f8d-7ced10f7e51e" source="shh1_s_shh2_s129_shh1_shh2_sa117" target="pr_3603d869-fc6e-4bed-8bc1-2839f8c00950_p1"> <start x="18758.0" y="4154.0"/> <end x="18784.5" y="4154.0"/> </arc> <arc class="production" id="prod_f262b78b-0e47-405b-a5bd-1f7ed927b6d4" source="pr_3603d869-fc6e-4bed-8bc1-2839f8c00950_p2" target="shh1_s_shh2_s130_shh1_shh2_sa118"> <start x="18814.5" y="4154.0"/> <end x="18841.0" y="4154.0"/> </arc> <arc class="catalysis" id="modif_e8b9a740-ba91-45ce-9d65-095a1dbd3f71" source="shh1_s_shh2_s337_shh1_shh2_csa5" target="pr_3603d869-fc6e-4bed-8bc1-2839f8c00950"> <start x="18566.0" y="3311.0"/> <end x="18794.5" y="4149.0"/> </arc> <arc class="inhibition" id="modif_4c454118-f1b2-41c5-8d63-0c33fdc4680c" source="shh1_s_shh2_s129_shh1_shh2_sa117" target="pr_3603d869-fc6e-4bed-8bc1-2839f8c00950"> <start x="18758.0" y="4151.8525"/> <end x="18804.5" y="4149.0"/> </arc> <arc class="consumption" id="cons_b66962e8-bc62-4d4c-8633-fbc05f291f39" source="shh1_s_shh2_s130_shh1_shh2_sa118" target="pr_0999d5c4-adb8-4923-910a-dd9e3b9feef4_p1"> <start x="18921.959" y="4141.5"/> <end x="19047.402" y="3703.25"/> </arc> <arc class="production" id="prod_56034c31-ab64-48de-a7a9-b14ab0b1b479" source="pr_0999d5c4-adb8-4923-910a-dd9e3b9feef4_p2" target="shh1_s_shh2_s50_shh1_shh2_sa44"> <start x="19047.402" y="3673.25"/> <end x="19172.848" y="3235.0"/> </arc> <arc class="consumption" id="cons_a5c69a78-eda7-4c0f-97fa-73c4f0889a77" source="shh1_s652_shh1_shh2_sa119" target="pr_f390c60b-631e-4bdd-8e26-c876ab1069b5_p1"> <start x="18068.0" y="4348.0"/> <end x="18187.25" y="4348.0"/> </arc> <arc class="production" id="prod_7aca3203-5623-4e2e-a482-8f151155fdd3" source="pr_f390c60b-631e-4bdd-8e26-c876ab1069b5_p2" target="shh1_s_shh2_s132_shh1_shh2_sa120"> <start x="18217.25" y="4348.0"/> <end x="18336.5" y="4348.0"/> </arc> <arc class="catalysis" id="modif_0303e95d-60a5-4b45-b6ac-3f6d6b822f24" source="shh1_s_shh2_s141_shh1_shh2_sa128" target="pr_f390c60b-631e-4bdd-8e26-c876ab1069b5"> <start x="18139.0" y="4415.0"/> <end x="18202.25" y="4353.0"/> </arc> <arc class="consumption" id="cons_75eaa57e-7c5d-4889-ad3f-09f5f0567921" source="shh1_s_shh2_s337_shh1_shh2_csa5" target="pr_5f2974ef-96d4-408f-9ba0-502c3c2044cc_p1"> <start x="18516.0" y="3371.0"/> <next x="18518.0" y="4348.0"/> <end x="18495.514" y="4425.5"/> </arc> <arc class="consumption" id="cons_cbaeea2d-9c5f-4ee7-89a3-b5cf08a6e04d" source="shh1_s_shh2_s132_shh1_shh2_sa120" target="pr_5f2974ef-96d4-408f-9ba0-502c3c2044cc_p1"> <start x="18416.5" y="4348.0"/> <next x="18518.0" y="4348.0"/> <end x="18495.514" y="4425.5"/> </arc> <arc class="production" id="prod_edf2896d-d700-4d52-9ce9-dc7cac1cec05" source="pr_5f2974ef-96d4-408f-9ba0-502c3c2044cc_p2" target="shh1_s_shh2_s135_shh1_shh2_csa12"> <start x="18495.514" y="4455.5"/> <end x="18474.0" y="4529.0"/> </arc> <arc class="consumption" id="addreact_3586a514-a09f-47b2-ad2f-71a83aeaafc7" source="shh1_s_shh2_s133_shh1_shh2_sa121" target="pr_5f2974ef-96d4-408f-9ba0-502c3c2044cc_p1"> <start x="18417.0" y="4428.5"/> <end x="18495.514" y="4425.5"/> </arc> <arc class="consumption" id="addreact_961622cb-9d92-4ae9-9975-d55ce1f6bde3" source="shh1_s_shh2_s134_shh1_shh2_sa122" target="pr_5f2974ef-96d4-408f-9ba0-502c3c2044cc_p1"> <start x="18417.0" y="4511.0"/> <end x="18495.514" y="4425.5"/> </arc> <arc class="consumption" id="cons_0e83bda6-9538-4d37-b95a-08ddef0dfb8c" source="shh1_s_shh2_s142_shh1_shh2_sa129" target="pr_0ee0b8b1-0404-40b0-bbd2-b7bba54a371c_p1"> <start x="18758.0" y="4193.0"/> <end x="18784.5" y="4193.0"/> </arc> <arc class="production" id="prod_3ca94805-66b1-43e3-8c94-b8240f1ad171" source="pr_0ee0b8b1-0404-40b0-bbd2-b7bba54a371c_p2" target="shh1_s_shh2_s143_shh1_shh2_sa130"> <start x="18814.5" y="4193.0"/> <end x="18841.0" y="4193.0"/> </arc> <arc class="catalysis" id="modif_d2090f3f-4d27-4b28-8475-7289fa36bb0d" source="shh1_s_shh2_s337_shh1_shh2_csa5" target="pr_0ee0b8b1-0404-40b0-bbd2-b7bba54a371c"> <start x="18566.0" y="3311.0"/> <end x="18794.5" y="4188.0"/> </arc> <arc class="catalysis" id="modif_4814cf83-d61a-4951-a871-2791885e0a4f" source="shh1_s_shh2_s335_shh1_shh2_csa13" target="pr_0ee0b8b1-0404-40b0-bbd2-b7bba54a371c"> <start x="18566.0" y="3020.0"/> <end x="18804.5" y="4188.0"/> </arc> <arc class="catalysis" id="modif_17a741c6-4eff-4551-a6ce-5daac2d84014" source="shh1_s_shh2_s338_shh1_shh2_csa16" target="pr_0ee0b8b1-0404-40b0-bbd2-b7bba54a371c"> <start x="18651.0" y="4204.5"/> <end x="18799.5" y="4198.0"/> </arc> <arc class="consumption" id="cons_408db530-c845-4b66-a4fa-b4f7ca55df8c" source="shh1_s_shh2_s146_shh1_shh2_sa132" target="pr_9c1e5fdc-8120-472a-9ae2-1f1df120d2b5_p1"> <start x="18144.438" y="2893.0"/> <end x="18198.762" y="2946.5"/> </arc> <arc class="production" id="prod_2ff450c3-f00e-4319-a7e0-72bc3cd7b991" source="pr_9c1e5fdc-8120-472a-9ae2-1f1df120d2b5_p2" target="shh1_s_shh2_s145_shh1_shh2_sa131"> <start x="18228.762" y="2946.5"/> <end x="18283.084" y="3000.0"/> </arc> <arc class="consumption" id="cons_1945b212-5b6e-4abc-aa91-8190b5f04f3d" source="shh1_s_shh2_s145_shh1_shh2_sa131" target="pr_e88ac042-687e-4ef4-9af6-58d8161a8afb_p1"> <start x="18349.0" y="3020.0"/> <next x="18376.75" y="3020.0"/> <end x="18408.375" y="3020.0"/> </arc> <arc class="consumption" id="cons_119ca28c-cf3f-488c-8531-bc22ad4dbd22" source="shh1_s_shh2_s14_shh1_shh2_sa11" target="pr_e88ac042-687e-4ef4-9af6-58d8161a8afb_p1"> <start x="18345.0" y="3222.0"/> <next x="18376.75" y="3020.0"/> <end x="18408.375" y="3020.0"/> </arc> <arc class="production" id="prod_1bab302d-2d36-41cf-8c9e-54f40c76b476" source="pr_e88ac042-687e-4ef4-9af6-58d8161a8afb_p2" target="shh1_s_shh2_s335_shh1_shh2_csa13"> <start x="18438.375" y="3020.0"/> <end x="18466.0" y="3020.0"/> </arc> <arc class="consumption" id="cons_382a28d7-28a0-4b8d-9ee7-f1e884434dd2" source="shh1_s_shh2_s143_shh1_shh2_sa130" target="pr_c1dead5c-a3d5-4d72-801a-852cb7d36dd8_p1"> <start x="18922.066" y="4180.5"/> <end x="19047.395" y="3756.25"/> </arc> <arc class="production" id="prod_a8af4530-66bb-41d5-99dc-4a8e2628b193" source="pr_c1dead5c-a3d5-4d72-801a-852cb7d36dd8_p2" target="shh1_s_shh2_s53_shh1_shh2_sa47"> <start x="19047.395" y="3726.25"/> <end x="19172.72" y="3302.0"/> </arc> <arc class="consumption" id="cons_cc1281d1-c01c-456d-a011-0916b87c7f29" source="shh1_s_shh2_s149_shh1_shh2_sa135" target="pr_07b32288-b72e-45a0-9701-39b82f54f443_p1"> <start x="18758.0" y="4229.0"/> <end x="18784.5" y="4229.0"/> </arc> <arc class="production" id="prod_b2d89a5e-abfe-44e5-b6cf-5b033ebe5333" source="pr_07b32288-b72e-45a0-9701-39b82f54f443_p2" target="shh1_s_shh2_s150_shh1_shh2_sa136"> <start x="18814.5" y="4229.0"/> <end x="18841.0" y="4229.0"/> </arc> <arc class="catalysis" id="modif_8af6b939-1ada-4755-932b-cea03afa456d" source="shh1_s_shh2_s338_shh1_shh2_csa16" target="pr_07b32288-b72e-45a0-9701-39b82f54f443"> <start x="18651.0" y="4204.5"/> <end x="18794.5" y="4224.0"/> </arc> <arc class="catalysis" id="modif_fed33efc-9034-4541-b562-b00b39800442" source="shh1_s_shh2_s337_shh1_shh2_csa5" target="pr_07b32288-b72e-45a0-9701-39b82f54f443"> <start x="18566.0" y="3311.0"/> <end x="18804.5" y="4224.0"/> </arc> <arc class="catalysis" id="modif_1d293683-c318-44e7-a04f-4225109f4ad2" source="shh1_s_shh2_s158_shh1_shh2_csa15" target="pr_07b32288-b72e-45a0-9701-39b82f54f443"> <start x="18656.5" y="4387.0"/> <end x="18799.5" y="4234.0"/> </arc> <arc class="consumption" id="cons_f088dffe-05d4-4227-88df-e547ec70ada6" source="shh1_s_shh2_s150_shh1_shh2_sa136" target="pr_c0b6e1c2-032a-4a55-920f-a0657e9a97f6_p1"> <start x="18923.174" y="4216.5"/> <end x="19046.281" y="3902.25"/> </arc> <arc class="production" id="prod_e6cc025e-b08e-428c-8b6f-100e334c688c" source="pr_c0b6e1c2-032a-4a55-920f-a0657e9a97f6_p2" target="shh1_s_shh2_s151_shh1_shh2_sa137"> <start x="19046.281" y="3872.25"/> <end x="19169.39" y="3558.0"/> </arc> <arc class="consumption" id="cons_c99339e9-32b5-42a2-a1db-6d6ba0ec2e9a" source="shh1_s_shh2_s150_shh1_shh2_sa136" target="pr_e9efaf54-afb4-41ed-9833-c19f59d613d4_p1"> <start x="18923.639" y="4216.5"/> <end x="19046.236" y="3933.25"/> </arc> <arc class="production" id="prod_7f844ee0-fcf6-47ef-9d55-41712cf70344" source="pr_e9efaf54-afb4-41ed-9833-c19f59d613d4_p2" target="shh1_s_shh2_s152_shh1_shh2_sa138"> <start x="19046.236" y="3903.25"/> <end x="19168.834" y="3620.0"/> </arc> <arc class="consumption" id="cons_de5b80cb-81a3-4a21-b6ee-09ba1931c789" source="shh1_s_shh2_s25_shh1_shh2_sa18" target="pr_35bd7a65-a313-4720-998f-7dc862393628_p1"> <start x="18355.0" y="3366.0"/> <next x="18530.5" y="4212.0"/> <end x="18527.75" y="4207.5186"/> </arc> <arc class="consumption" id="cons_3ed40f71-110b-4331-9dd1-d87c20f653a7" source="shh1_s_shh2_s14_shh1_shh2_sa11" target="pr_35bd7a65-a313-4720-998f-7dc862393628_p1"> <start x="18345.0" y="3222.0"/> <next x="18530.5" y="4212.0"/> <end x="18527.75" y="4207.5186"/> </arc> <arc class="production" id="prod_78e64b92-cbda-4231-b3f0-0d388460f6d4" source="pr_35bd7a65-a313-4720-998f-7dc862393628_p2" target="shh1_s_shh2_s338_shh1_shh2_csa16"> <start x="18557.75" y="4207.5186"/> <end x="18551.0" y="4204.5"/> </arc> <arc class="consumption" id="addreact_2f9b9b16-cbf2-4a6c-a9ad-849f1542f8f1" source="shh1_s_shh2_s145_shh1_shh2_sa139" target="pr_35bd7a65-a313-4720-998f-7dc862393628_p1"> <start x="18362.375" y="4247.0"/> <end x="18527.75" y="4207.5186"/> </arc> <arc class="consumption" id="cons_17f9f552-e3e9-46dd-b143-57cf0bfc219b" source="shh1_s_shh2_s14_shh1_shh2_sa11" target="pr_3595e939-4a9c-479b-ba89-3f82f67b0d27_p1"> <start x="18345.0" y="3222.0"/> <next x="18386.375" y="4245.0"/> <end x="18458.438" y="4317.6694"/> </arc> <arc class="consumption" id="cons_e21f5b65-8992-485f-83d6-a78b643aa54e" source="shh1_s_shh2_s145_shh1_shh2_sa139" target="pr_3595e939-4a9c-479b-ba89-3f82f67b0d27_p1"> <start x="18362.375" y="4247.0"/> <next x="18386.375" y="4245.0"/> <end x="18458.438" y="4317.6694"/> </arc> <arc class="production" id="prod_eff815ff-ce47-4e09-8685-09cc36cdbf76" source="pr_3595e939-4a9c-479b-ba89-3f82f67b0d27_p2" target="shh1_s_shh2_s158_shh1_shh2_csa15"> <start x="18488.438" y="4317.6694"/> <end x="18556.5" y="4387.0"/> </arc> <arc class="consumption" id="cons_44b74207-1810-455d-9d8e-08721837c3a0" source="shh1_s_shh2_s164_shh1_shh2_sa146" target="pr_32865b81-3107-4ec1-89f8-3824d20187ab_p1"> <start x="18758.0" y="4266.0"/> <end x="18784.5" y="4266.0"/> </arc> <arc class="production" id="prod_7bb40261-756b-4e9c-b935-bff4b45f9ecb" source="pr_32865b81-3107-4ec1-89f8-3824d20187ab_p2" target="shh1_s_shh2_s165_shh1_shh2_sa147"> <start x="18814.5" y="4266.0"/> <end x="18841.0" y="4266.0"/> </arc> <arc class="catalysis" id="modif_6492a3e1-e2c9-4b4a-af2f-16baeccf6ca1" source="shh1_s_shh2_s158_shh1_shh2_csa15" target="pr_32865b81-3107-4ec1-89f8-3824d20187ab"> <start x="18656.5" y="4387.0"/> <end x="18799.5" y="4271.0"/> </arc> <arc class="catalysis" id="modif_790122f5-fe29-4ba3-8e4c-748f6215d91a" source="shh1_s_shh2_s338_shh1_shh2_csa16" target="pr_32865b81-3107-4ec1-89f8-3824d20187ab"> <start x="18651.0" y="4204.5"/> <end x="18794.5" y="4261.0"/> </arc> <arc class="catalysis" id="modif_8ce25622-b4cb-4e74-a5f9-df6cbcac24d7" source="shh1_s_shh2_s337_shh1_shh2_csa5" target="pr_32865b81-3107-4ec1-89f8-3824d20187ab"> <start x="18566.0" y="3311.0"/> <end x="18804.5" y="4261.0"/> </arc> <arc class="consumption" id="cons_98c4fe15-96db-4ff9-945a-51ea5f07590f" source="shh1_s_shh2_s165_shh1_shh2_sa147" target="pr_bf58b5bc-c510-452b-9362-9f50be2bfb05_p1"> <start x="18923.352" y="4253.5"/> <end x="19046.266" y="3951.75"/> </arc> <arc class="production" id="prod_771bfb8c-b60d-4367-b6c9-e26783aa6e7b" source="pr_bf58b5bc-c510-452b-9362-9f50be2bfb05_p2" target="shh1_s_shh2_s152_shh1_shh2_sa138"> <start x="19046.266" y="3921.75"/> <end x="19169.18" y="3620.0"/> </arc> <arc class="consumption" id="cons_de9b8e91-71b5-4c42-a42f-e6e4c1711342" source="shh1_s_shh2_s165_shh1_shh2_sa147" target="pr_59971b74-aa37-4898-bbdd-b0a792bcfd56_p1"> <start x="18922.936" y="4253.5"/> <end x="19046.307" y="3920.75"/> </arc> <arc class="production" id="prod_c642dbce-f5f3-422e-8ee9-0b9d2d9aba3f" source="pr_59971b74-aa37-4898-bbdd-b0a792bcfd56_p2" target="shh1_s_shh2_s151_shh1_shh2_sa137"> <start x="19046.307" y="3890.75"/> <end x="19169.678" y="3558.0"/> </arc> <arc class="consumption" id="cons_1009a5f7-b1c0-4ea7-9759-fa1a9aaa809d" source="shh1_s_shh2_s166_shh1_shh2_sa148" target="pr_7498586a-0451-4ede-851e-8e319cb96682_p1"> <start x="18758.0" y="4300.0"/> <end x="18784.5" y="4300.0"/> </arc> <arc class="production" id="prod_5c86e36d-c5a9-4ae0-a2aa-6c27aea83c8a" source="pr_7498586a-0451-4ede-851e-8e319cb96682_p2" target="shh1_s_shh2_s167_shh1_shh2_sa149"> <start x="18814.5" y="4300.0"/> <end x="18841.0" y="4300.0"/> </arc> <arc class="consumption" id="cons_d6119073-572a-4520-94d9-6af4ef5e50af" source="shh1_s_shh2_s167_shh1_shh2_sa149" target="pr_564cb5d3-1488-4376-9e5b-5d02e5da8ba1_p1"> <start x="18924.086" y="4287.5"/> <end x="19046.191" y="4029.25"/> </arc> <arc class="production" id="prod_5ce39cad-ce07-492f-9055-c59f5f7b828e" source="pr_564cb5d3-1488-4376-9e5b-5d02e5da8ba1_p2" target="shh1_s_shh2_s169_shh1_shh2_sa151"> <start x="19046.191" y="3999.25"/> <end x="19168.297" y="3741.0"/> </arc> <arc class="consumption" id="cons_a77356b0-ade5-4249-9ebc-5f4f8f8c0ab9" source="shh1_s_shh2_s170_shh1_shh2_sa152" target="pr_b469cdeb-15de-4f82-85b2-f7296bbd5c5c_p1"> <start x="18758.0" y="4334.0"/> <end x="18784.5" y="4334.0"/> </arc> <arc class="production" id="prod_63f1448e-1c86-49b5-8fa5-cfb8bf61e1ff" source="pr_b469cdeb-15de-4f82-85b2-f7296bbd5c5c_p2" target="shh1_s_shh2_s171_shh1_shh2_sa153"> <start x="18814.5" y="4334.0"/> <end x="18841.0" y="4334.0"/> </arc> <arc class="catalysis" id="modif_5bb45119-c2cc-4d87-8893-bca927f24c7f" source="shh1_s_shh2_s158_shh1_shh2_csa15" target="pr_b469cdeb-15de-4f82-85b2-f7296bbd5c5c"> <start x="18656.5" y="4387.0"/> <end x="18799.5" y="4339.0"/> </arc> <arc class="catalysis" id="modif_1f4f165c-6ec5-4618-9641-faef134dc280" source="shh1_s_shh2_s338_shh1_shh2_csa16" target="pr_b469cdeb-15de-4f82-85b2-f7296bbd5c5c"> <start x="18651.0" y="4204.5"/> <end x="18794.5" y="4329.0"/> </arc> <arc class="catalysis" id="modif_72ddfd04-eded-4e0d-a191-5fdaf72065e5" source="shh1_s_shh2_s337_shh1_shh2_csa5" target="pr_b469cdeb-15de-4f82-85b2-f7296bbd5c5c"> <start x="18566.0" y="3311.0"/> <end x="18804.5" y="4329.0"/> </arc> <arc class="consumption" id="cons_208631f9-d9f0-462f-930d-6143e487bbc0" source="shh1_s_shh2_s171_shh1_shh2_sa153" target="pr_01f414e2-24f8-4ae3-b0ae-c9fc4cbdd80e_p1"> <start x="18924.225" y="4321.5"/> <end x="19046.176" y="4070.25"/> </arc> <arc class="production" id="prod_3cc9ed92-a9da-4a58-a7f2-36161c6beb4c" source="pr_01f414e2-24f8-4ae3-b0ae-c9fc4cbdd80e_p2" target="shh1_s_shh2_s172_shh1_shh2_sa154"> <start x="19046.176" y="4040.25"/> <end x="19168.129" y="3789.0"/> </arc> <arc class="consumption" id="cons_9144f536-8d5d-4b78-b62b-3f4af0fab7ab" source="shh1_s_shh2_s173_shh1_shh2_sa155" target="pr_d8fb312d-167f-442d-b7e6-930ff566ba73_p1"> <start x="18758.0" y="4369.0"/> <end x="18784.5" y="4369.0"/> </arc> <arc class="production" id="prod_04dc1f3f-6916-4dd8-ac86-50148b95d8cf" source="pr_d8fb312d-167f-442d-b7e6-930ff566ba73_p2" target="shh1_s_shh2_s174_shh1_shh2_sa156"> <start x="18814.5" y="4369.0"/> <end x="18841.0" y="4369.0"/> </arc> <arc class="catalysis" id="modif_c1743580-2f51-4b1e-b607-f9a2d2aa7108" source="shh1_s_shh2_s158_shh1_shh2_csa15" target="pr_d8fb312d-167f-442d-b7e6-930ff566ba73"> <start x="18656.5" y="4387.0"/> <end x="18794.5" y="4374.0"/> </arc> <arc class="catalysis" id="modif_b3bac716-c71f-4f97-9a59-1892b8e49aec" source="shh1_s_shh2_s338_shh1_shh2_csa16" target="pr_d8fb312d-167f-442d-b7e6-930ff566ba73"> <start x="18651.0" y="4204.5"/> <end x="18794.5" y="4364.0"/> </arc> <arc class="catalysis" id="modif_2ec20fc7-8785-4b26-9e2c-d05e157fd752" source="shh1_s_shh2_s337_shh1_shh2_csa5" target="pr_d8fb312d-167f-442d-b7e6-930ff566ba73"> <start x="18566.0" y="3311.0"/> <end x="18804.5" y="4364.0"/> </arc> <arc class="consumption" id="cons_ea324a56-d0d3-4186-ba7e-c675c8561773" source="shh1_s_shh2_s174_shh1_shh2_sa156" target="pr_ee5a4ed0-5a15-448b-b9ac-992b38a1a34c_p1"> <start x="18924.482" y="4356.5"/> <end x="19046.152" y="4117.25"/> </arc> <arc class="production" id="prod_7ad0be8c-8b5f-4a65-a78a-304ae075662d" source="pr_ee5a4ed0-5a15-448b-b9ac-992b38a1a34c_p2" target="shh1_s_shh2_s175_shh1_shh2_sa157"> <start x="19046.152" y="4087.25"/> <end x="19167.822" y="3848.0"/> </arc> <arc class="consumption" id="cons_4e0bc6fd-ea09-452e-8947-47de892dbad1" source="shh1_s_shh2_s185_shh1_shh2_sa165" target="pr_5ac63c08-8413-4d3b-bec1-528b4e4fd7a1_p1"> <start x="18758.0" y="4404.0"/> <end x="18784.5" y="4404.0"/> </arc> <arc class="production" id="prod_b074f92a-438a-4858-b474-7c74af20b2fd" source="pr_5ac63c08-8413-4d3b-bec1-528b4e4fd7a1_p2" target="shh1_s_shh2_s186_shh1_shh2_sa166"> <start x="18814.5" y="4404.0"/> <end x="18841.0" y="4404.0"/> </arc> <arc class="catalysis" id="modif_8456a36f-790c-44c8-90f0-e5a2e9d40571" source="shh1_s_shh2_s183_shh1_shh2_csa17" target="pr_5ac63c08-8413-4d3b-bec1-528b4e4fd7a1"> <start x="19000.0" y="4299.5"/> <end x="18799.5" y="4399.0"/> </arc> <arc class="consumption" id="cons_bd552780-47a2-430a-b061-709864e895f9" source="shh1_s_shh2_s187_shh1_shh2_sa167" target="pr_97899350-a41b-485b-b650-7f81aecd1578_p1"> <start x="18758.0" y="4438.0"/> <end x="18784.5" y="4438.0"/> </arc> <arc class="production" id="prod_3a474193-041a-4e98-bbac-c6ab99781d7f" source="pr_97899350-a41b-485b-b650-7f81aecd1578_p2" target="shh1_s_shh2_s188_shh1_shh2_sa168"> <start x="18814.5" y="4438.0"/> <end x="18841.0" y="4438.0"/> </arc> <arc class="catalysis" id="modif_8beb1824-b90c-4057-8720-0dfe0132d293" source="shh1_s_shh2_s337_shh1_shh2_csa5" target="pr_97899350-a41b-485b-b650-7f81aecd1578"> <start x="18566.0" y="3311.0"/> <end x="18799.5" y="4433.0"/> </arc> <arc class="consumption" id="cons_77859dd6-deef-4cf3-95ef-5156111f3061" source="shh1_s_shh2_s188_shh1_shh2_sa168" target="pr_277cbb57-57d3-4cea-8d28-7f995aca0686_p1"> <start x="18921.152" y="4425.5"/> <end x="19047.484" y="3845.25"/> </arc> <arc class="production" id="prod_4bf50bfe-1d2a-47db-9515-078225703d29" source="pr_277cbb57-57d3-4cea-8d28-7f995aca0686_p2" target="shh1_s_shh2_s50_shh1_shh2_sa44"> <start x="19047.484" y="3815.25"/> <end x="19173.816" y="3235.0"/> </arc> <arc class="consumption" id="cons_8d14425a-abad-4588-9ad0-67c45f53b8c0" source="shh1_s_shh2_s189_shh1_shh2_sa169" target="pr_c9fd73d1-cd84-4cad-909d-46e358208c04_p1"> <start x="18758.0" y="4476.0"/> <end x="18784.5" y="4476.0"/> </arc> <arc class="production" id="prod_9fa12df6-4de8-421b-bdd4-d296c3a3f4c6" source="pr_c9fd73d1-cd84-4cad-909d-46e358208c04_p2" target="shh1_s_shh2_s190_shh1_shh2_sa170"> <start x="18814.5" y="4476.0"/> <end x="18841.0" y="4476.0"/> </arc> <arc class="inhibition" id="modif_54e76929-ba77-4220-8a8c-94952ebd9b2d" source="shh1_s_shh2_s336_shh1_shh2_csa2" target="pr_c9fd73d1-cd84-4cad-909d-46e358208c04"> <start x="18599.0" y="3173.0"/> <end x="18799.5" y="4471.0"/> </arc> <arc class="consumption" id="cons_f9d551d2-5264-426b-8213-68ae3fbd62a9" source="shh1_s_shh2_s190_shh1_shh2_sa170" target="pr_a0cec72f-1a32-4317-bc42-b4ebd9463dbf_p1"> <start x="18920.936" y="4463.5"/> <end x="19047.508" y="3828.75"/> </arc> <arc class="production" id="prod_694feddf-d663-4553-886f-0eba83639307" source="pr_a0cec72f-1a32-4317-bc42-b4ebd9463dbf_p2" target="shh1_s_shh2_s41_shh1_shh2_sa35"> <start x="19047.508" y="3798.75"/> <end x="19174.078" y="3164.0"/> </arc> <arc class="consumption" id="cons_1df9d5ed-dfd1-457c-9826-846262df608e" source="shh1_s_shh2_s191_shh1_shh2_sa171" target="pr_db05e29e-bc52-4311-9601-66b67f3eb21a_p1"> <start x="18758.0" y="3904.0"/> <end x="18784.5" y="3904.0"/> </arc> <arc class="production" id="prod_a9fdfdc3-8056-4d91-824f-95a96e77ddbc" source="pr_db05e29e-bc52-4311-9601-66b67f3eb21a_p2" target="shh1_s_shh2_s192_shh1_shh2_sa172"> <start x="18814.5" y="3904.0"/> <end x="18841.0" y="3904.0"/> </arc> <arc class="inhibition" id="modif_834d6ebd-da77-4e89-b8a1-b8c0fc63c594" source="shh1_s_shh2_s336_shh1_shh2_csa2" target="pr_db05e29e-bc52-4311-9601-66b67f3eb21a"> <start x="18599.0" y="3173.0"/> <end x="18799.5" y="3899.0"/> </arc> <arc class="consumption" id="cons_f2e96dc6-b643-4d93-8357-75485b97e58b" source="shh1_s_shh2_s192_shh1_shh2_sa172" target="pr_c0c077e4-30bf-45a9-8d91-aaa4bc48b501_p1"> <start x="18926.045" y="3891.5"/> <end x="19045.996" y="3707.75"/> </arc> <arc class="production" id="prod_973254a2-c0c0-4718-9580-5eb84a801f3c" source="pr_c0c077e4-30bf-45a9-8d91-aaa4bc48b501_p2" target="shh1_s_shh2_s96_shh1_shh2_sa90"> <start x="19045.996" y="3677.75"/> <end x="19165.947" y="3494.0"/> </arc> <arc class="consumption" id="cons_c1587c5f-4692-46c8-8f5d-7ccf51322986" source="shh1_s_shh2_s193_shh1_shh2_sa173" target="pr_1e7d33ce-b26a-49bd-9fa7-cf245ab22c9e_p1"> <start x="19217.5" y="4245.0"/> <next x="19191.5" y="4298.0"/> <end x="19161.25" y="4298.7847"/> </arc> <arc class="consumption" id="cons_7823c907-f037-423f-9fed-0353acee8cbc" source="shh1_s_shh2_s194_shh1_shh2_sa174" target="pr_1e7d33ce-b26a-49bd-9fa7-cf245ab22c9e_p1"> <start x="19217.5" y="4326.0"/> <next x="19191.5" y="4298.0"/> <end x="19161.25" y="4298.7847"/> </arc> <arc class="production" id="prod_e6d50b91-90e4-4c57-b648-25234c34db59" source="pr_1e7d33ce-b26a-49bd-9fa7-cf245ab22c9e_p2" target="shh1_s_shh2_s183_shh1_shh2_csa17"> <start x="19131.25" y="4298.7847"/> <end x="19105.0" y="4299.5"/> </arc> <arc class="consumption" id="addreact_cf089dae-0a97-48c2-95a6-e2e341935ffb" source="shh1_s_shh2_s14_shh1_shh2_sa11" target="pr_1e7d33ce-b26a-49bd-9fa7-cf245ab22c9e_p1"> <start x="18345.0" y="3222.0"/> <end x="19161.25" y="4298.7847"/> </arc> <arc class="consumption" id="cons_e3dd4c2e-96bd-4ad3-95b8-0f3b83407dac" source="shh1_s_shh2_s194_shh1_shh2_sa174" target="pr_8296cd0d-3997-4cab-9663-dac852ab434d_p1"> <start x="19217.5" y="4326.0"/> <next x="19169.25" y="4326.0"/> <end x="19136.291" y="4390.0"/> </arc> <arc class="consumption" id="cons_ba0de94c-0b19-4293-9f13-129bf8e753f9" source="shh1_s_shh2_s13_shh1_shh2_sa10" target="pr_8296cd0d-3997-4cab-9663-dac852ab434d_p1"> <start x="18356.0" y="3166.75"/> <next x="19169.25" y="4326.0"/> <end x="19136.291" y="4390.0"/> </arc> <arc class="production" id="prod_6833191c-e45d-4117-a188-fded312f0ef9" source="pr_8296cd0d-3997-4cab-9663-dac852ab434d_p2" target="shh1_s_shh2_s195_shh1_shh2_csa18"> <start x="19136.291" y="4420.0"/> <end x="19105.0" y="4480.0"/> </arc> <arc class="consumption" id="cons_d5dcb73e-1773-449d-bfc1-40f237e585d8" source="shh1_s_shh2_s199_shh1_shh2_sa178" target="pr_cce4136c-040b-415c-ae81-61738d07f529_p1"> <start x="19828.0" y="3945.0"/> <next x="19892.0" y="3990.5"/> <end x="19892.0" y="4000.25"/> </arc> <arc class="consumption" id="cons_a798164c-fb69-43d4-a3c9-0f58f92d9a05" source="shh1_s_shh2_s198_shh1_shh2_sa177" target="pr_cce4136c-040b-415c-ae81-61738d07f529_p1"> <start x="19960.0" y="3945.0"/> <next x="19892.0" y="3990.5"/> <end x="19892.0" y="4000.25"/> </arc> <arc class="production" id="prod_5e476d3e-feb2-43fc-b49f-4cc1e70d3f59" source="pr_cce4136c-040b-415c-ae81-61738d07f529_p2" target="shh1_s677_shh1_shh2_csa19"> <start x="19892.0" y="4030.25"/> <end x="19892.0" y="4036.0"/> </arc> <arc class="consumption" id="cons_5d01041b-826b-483a-9ff8-d7475b3a8740" source="shh1_s_shh2_s198_shh1_shh2_sa177" target="pr_cbb13cce-344c-473d-aa5a-8761865551ba_p1"> <start x="19960.0" y="3945.0"/> <next x="20034.0" y="3990.5"/> <end x="20034.0" y="4000.25"/> </arc> <arc class="consumption" id="cons_b5549472-6b36-44d2-9700-8b39aebb1fc7" source="shh1_s_shh2_s326_shh1_shh2_sa179" target="pr_cbb13cce-344c-473d-aa5a-8761865551ba_p1"> <start x="20092.0" y="3945.0"/> <next x="20034.0" y="3990.5"/> <end x="20034.0" y="4000.25"/> </arc> <arc class="production" id="prod_9930d93f-2f81-46cc-8f7e-e12722cbefcd" source="pr_cbb13cce-344c-473d-aa5a-8761865551ba_p2" target="shh1_s_shh2_s205_shh1_shh2_csa20"> <start x="20034.0" y="4030.25"/> <end x="20034.0" y="4036.0"/> </arc> <arc class="consumption" id="cons_e346862f-9119-4e68-9df2-bd0d836dacf3" source="shh1_s_shh2_s326_shh1_shh2_sa179" target="pr_214e5705-9da8-45f6-bfa1-69a612eb2fa7_p1"> <start x="20104.5" y="3932.5"/> <end x="19663.996" y="3518.25"/> </arc> <arc class="production" id="prod_6fbed247-597d-4ab4-b5cb-0b3d33f6230e" source="pr_214e5705-9da8-45f6-bfa1-69a612eb2fa7_p2" target="shh1_s_shh2_s21_shh1_shh2_sa17"> <start x="19633.996" y="3518.25"/> <end x="19193.494" y="3104.0"/> </arc> <arc class="consumption" id="cons_ec097ad3-b3f8-41a2-92b6-8759431fa59a" source="shh1_s_shh2_s108_shh1_shh2_sa36" target="pr_7126fe72-0edc-4e14-bbe7-c8022264ed70_p1"> <start x="19451.572" y="3053.6802"/> <end x="19479.375" y="3066.34"/> </arc> <arc class="production" id="prod_d67bf33a-f80a-47c7-ac8e-ff44cd8258f5" source="pr_7126fe72-0edc-4e14-bbe7-c8022264ed70_p2" target="shh1_s_shh2_s209_shh1_shh2_sa185"> <start x="19509.375" y="3066.34"/> <end x="19537.178" y="3079.0"/> </arc> <arc class="catalysis" id="logicarc_d41880dd-ba48-4564-aa2c-addd70a6efe8" source="logicglyph_077f9b36-590c-4f89-8e84-714cd393a395_p2" target="pr_7126fe72-0edc-4e14-bbe7-c8022264ed70"> <start x="19657.0" y="3251.75"/> <end x="19497.752" y="3072.553"/> </arc> <arc class="logic arc" id="modif_dc114c74-f20d-4e13-b2dc-e578da94a0e4" source="shh1_s_shh2_s10_shh1_shh2_sa7" target="logicglyph_077f9b36-590c-4f89-8e84-714cd393a395_p1"> <start x="19743.5" y="3148.0"/> <end x="19697.0" y="3251.75"/> </arc> <arc class="logic arc" id="modif_2a561ef5-a1da-431b-9bd4-edb4b72be632" source="shh1_s_shh2_s11_shh1_shh2_sa8" target="logicglyph_077f9b36-590c-4f89-8e84-714cd393a395_p1"> <start x="19743.5" y="3242.0"/> <end x="19697.0" y="3251.75"/> </arc> <arc class="logic arc" id="modif_17f8adb4-3050-441b-8f37-816d3ceb8475" source="shh1_s_shh2_s5_shh1_shh2_csa1" target="logicglyph_077f9b36-590c-4f89-8e84-714cd393a395_p1"> <start x="19733.5" y="3376.0"/> <end x="19697.0" y="3251.75"/> </arc> <arc class="consumption" id="cons_99741f3b-20cc-427d-b6d8-0b4c6bf8dee0" source="shh1_s670_shh1_shh2_csa21" target="pr_b38378e0-5b8c-4a90-a598-d8014f275969_p1"> <start x="19391.0" y="3631.0"/> <next x="19391.0" y="3647.0"/> <end x="19390.465" y="3661.75"/> </arc> <arc class="consumption" id="cons_a0228f51-0a81-4764-942f-f129ceede063" source="shh1_s_shh2_s226_shh1_shh2_sa200" target="pr_b38378e0-5b8c-4a90-a598-d8014f275969_p1"> <start x="19597.0" y="3647.0"/> <next x="19391.0" y="3647.0"/> <end x="19390.465" y="3661.75"/> </arc> <arc class="production" id="prod_008dd95c-dc7f-4798-80a4-f2b2ff873515" source="pr_b38378e0-5b8c-4a90-a598-d8014f275969_p2" target="shh1_s_shh2_s210_shh1_shh2_csa22"> <start x="19390.465" y="3691.75"/> <end x="19390.0" y="3702.5"/> </arc> <arc class="consumption" id="addreact_666e5cce-9186-4c5b-bea1-46c677730255" source="shh1_s_shh2_s14_shh1_shh2_sa72" target="pr_b38378e0-5b8c-4a90-a598-d8014f275969_p1"> <start x="19852.053" y="3061.0"/> <end x="19390.465" y="3661.75"/> </arc> <arc class="consumption" id="addreact_da9ae200-343f-46bc-8368-5b649de66136" source="shh1_s_shh2_s100_shh1_shh2_sa2" target="pr_b38378e0-5b8c-4a90-a598-d8014f275969_p1"> <start x="19989.982" y="3069.0"/> <end x="19390.465" y="3661.75"/> </arc> <arc class="consumption" id="cons_235c75ce-f968-4c5d-b92d-4f0c3c1a5d91" source="shh1_s_shh2_s230_shh1_shh2_sa204" target="pr_82cccb67-eeed-4acf-bba9-f4209ecf8db9_p1"> <start x="18611.355" y="2681.0"/> <end x="18930.5" y="3478.5"/> </arc> <arc class="production" id="prod_3e1f2e5d-96e7-4d4d-b498-7e2d8266aff3" source="pr_82cccb67-eeed-4acf-bba9-f4209ecf8db9_p2" target="shh1_s_shh2_s194_shh1_shh2_sa174"> <start x="18930.5" y="3508.5"/> <end x="19249.645" y="4306.0"/> </arc> <arc class="catalysis" id="modif_c8039bf1-6c76-4927-9307-4447d40b5863" source="shh1_s650_shh1_shh2_sa27" target="pr_82cccb67-eeed-4acf-bba9-f4209ecf8db9"> <start x="18066.75" y="3469.2158"/> <end x="18925.846" y="3495.3281"/> </arc> <arc class="consumption" id="cons_6b6fe3c3-9177-491b-bee6-c488d34ce470" source="shh1_s_shh2_s232_shh1_shh2_sa205" target="pr_739cf038-db7f-40cf-a91a-413a16c0eda2_p1"> <start x="18115.0" y="4247.0"/> <end x="18183.688" y="4247.0"/> </arc> <arc class="production" id="prod_1f1ab8fe-bc31-4004-87e5-6d1b6adde42b" source="pr_739cf038-db7f-40cf-a91a-413a16c0eda2_p2" target="shh1_s_shh2_s145_shh1_shh2_sa139"> <start x="18213.688" y="4247.0"/> <end x="18282.375" y="4247.0"/> </arc> <arc class="consumption" id="cons_9c56b5cd-d805-4cc7-9476-a2ab7d59cb56" source="shh1_s_shh2_s244_shh1_shh2_sa212" target="pr_eb478e8c-d43f-4cd0-9d23-ea79c85c7abc_p1"> <start x="18758.0" y="4614.0"/> <end x="18785.0" y="4614.0"/> </arc> <arc class="production" id="prod_ed51023c-7365-4ea6-97b9-514be5f2f4b9" source="pr_eb478e8c-d43f-4cd0-9d23-ea79c85c7abc_p2" target="shh1_s_shh2_s245_shh1_shh2_sa213"> <start x="18815.0" y="4614.0"/> <end x="18842.0" y="4614.0"/> </arc> <arc class="inhibition" id="modif_17c781c0-5d7f-4359-9ef7-26a3fbd6eba1" source="shh1_s_shh2_s247_shh1_shh2_sa215" target="pr_eb478e8c-d43f-4cd0-9d23-ea79c85c7abc"> <start x="18748.0" y="2683.0"/> <end x="18800.0" y="4609.0"/> </arc> <arc class="consumption" id="cons_e5c15e1c-d1fa-4138-b340-96e09205aac7" source="shh1_s_shh2_s248_shh1_shh2_sa216" target="pr_c2503add-a375-446c-b421-6dd8a337a03e_p1"> <start x="18758.0" y="4658.0"/> <end x="18785.0" y="4658.0"/> </arc> <arc class="production" id="prod_e5266a2d-dfc1-480e-8828-2848887cc5e5" source="pr_c2503add-a375-446c-b421-6dd8a337a03e_p2" target="shh1_s_shh2_s198_shh1_shh2_sa217"> <start x="18815.0" y="4658.0"/> <end x="18842.0" y="4658.0"/> </arc> <arc class="catalysis" id="modif_0dfd5b2a-9b3b-4faf-a5c0-477685e111c6" source="shh1_s_shh2_s247_shh1_shh2_sa215" target="pr_c2503add-a375-446c-b421-6dd8a337a03e"> <start x="18748.0" y="2683.0"/> <end x="18800.0" y="4653.0"/> </arc> <arc class="consumption" id="cons_65bc1dc0-85b3-4a87-8b50-09893f45d988" source="shh1_s_shh2_s245_shh1_shh2_sa213" target="pr_9b219236-458e-41bb-88a5-a705fb12db89_p1"> <start x="18919.5" y="4614.0"/> <next x="19652.0" y="4115.0"/> <end x="19658.5" y="4104.5254"/> </arc> <arc class="consumption" id="cons_14069544-2abe-441c-9afa-e13034868f11" source="shh1_s_shh2_s258_shh1_shh2_sa227" target="pr_9b219236-458e-41bb-88a5-a705fb12db89_p1"> <start x="19581.5" y="4007.5"/> <next x="19652.0" y="4115.0"/> <end x="19658.5" y="4104.5254"/> </arc> <arc class="production" id="prod_8e3bc512-0bda-4770-8d90-d9ff9026f568" source="pr_9b219236-458e-41bb-88a5-a705fb12db89_p2" target="shh1_s_shh2_s250_shh1_shh2_csa25"> <start x="19688.5" y="4104.5254"/> <end x="19691.0" y="4096.0"/> </arc> <arc class="consumption" id="cons_72856b84-f580-477d-bf8f-d66c07148f4c" source="shh1_s_shh2_s259_shh1_shh2_sa228" target="pr_8c209c94-2fb8-480e-94f9-d44770ec8298_p1"> <start x="19634.5" y="4199.0"/> <next x="19662.0" y="4219.0"/> <end x="19663.5" y="4230.3794"/> </arc> <arc class="consumption" id="cons_6f5cc1e5-47b3-499f-98eb-72fd4ddb82a9" source="shh1_s_shh2_s245_shh1_shh2_sa213" target="pr_8c209c94-2fb8-480e-94f9-d44770ec8298_p1"> <start x="18919.5" y="4614.0"/> <next x="19662.0" y="4219.0"/> <end x="19663.5" y="4230.3794"/> </arc> <arc class="production" id="prod_61f5fdd1-5d92-4d68-b987-f19d17317fb3" source="pr_8c209c94-2fb8-480e-94f9-d44770ec8298_p2" target="shh1_s_shh2_s264_shh1_shh2_csa26"> <start x="19693.5" y="4230.3794"/> <end x="19691.0" y="4239.0"/> </arc> <arc class="consumption" id="cons_b81ed8e0-45cc-40f1-a352-8882dad339ef" source="shh1_s_shh2_s260_shh1_shh2_sa229" target="pr_c89facb9-6c26-4afe-96b8-6eaf8ad19796_p1"> <start x="19634.5" y="4233.0"/> <next x="19672.0" y="4244.0"/> <end x="19744.0" y="4241.4414"/> </arc> <arc class="consumption" id="cons_34639836-eabd-4f18-934e-b25953970235" source="shh1_s_shh2_s245_shh1_shh2_sa213" target="pr_c89facb9-6c26-4afe-96b8-6eaf8ad19796_p1"> <start x="18919.5" y="4614.0"/> <next x="19672.0" y="4244.0"/> <end x="19744.0" y="4241.4414"/> </arc> <arc class="production" id="prod_63a49839-052e-4864-9106-1d68f920b90a" source="pr_c89facb9-6c26-4afe-96b8-6eaf8ad19796_p2" target="shh1_s_shh2_s267_shh1_shh2_csa27"> <start x="19774.0" y="4241.4414"/> <end x="19842.0" y="4239.0"/> </arc> <arc class="consumption" id="cons_2eb26d28-8b1e-430e-9a45-924c3f0d1270" source="shh1_s_shh2_s261_shh1_shh2_sa230" target="pr_80b1155d-7ba4-42f4-9fcb-8c30862bd647_p1"> <start x="19634.5" y="4267.0"/> <next x="19668.0" y="4285.5"/> <end x="19813.0" y="4261.956"/> </arc> <arc class="consumption" id="cons_9c72839b-638a-4380-acaf-b40917745a0a" source="shh1_s_shh2_s245_shh1_shh2_sa213" target="pr_80b1155d-7ba4-42f4-9fcb-8c30862bd647_p1"> <start x="18919.5" y="4614.0"/> <next x="19668.0" y="4285.5"/> <end x="19813.0" y="4261.956"/> </arc> <arc class="production" id="prod_995d8f76-22fb-4508-9b12-7b926091f4d8" source="pr_80b1155d-7ba4-42f4-9fcb-8c30862bd647_p2" target="shh1_s_shh2_s270_shh1_shh2_csa28"> <start x="19843.0" y="4261.956"/> <end x="19984.0" y="4239.0"/> </arc> <arc class="consumption" id="cons_713d95f1-29e3-4240-b100-c8b2f8f0ccb8" source="shh1_s_shh2_s262_shh1_shh2_sa231" target="pr_305e9da7-9599-4135-ab4f-dc399c0ce0a3_p1"> <start x="19634.5" y="4301.0"/> <next x="19672.0" y="4356.0"/> <end x="19682.96" y="4356.0"/> </arc> <arc class="consumption" id="cons_384de9bf-59aa-443e-b1a9-caadc8193437" source="shh1_s_shh2_s245_shh1_shh2_sa213" target="pr_305e9da7-9599-4135-ab4f-dc399c0ce0a3_p1"> <start x="18919.5" y="4614.0"/> <next x="19672.0" y="4356.0"/> <end x="19682.96" y="4356.0"/> </arc> <arc class="production" id="prod_d960150d-0bbd-4ef0-8ff3-089e340e0500" source="pr_305e9da7-9599-4135-ab4f-dc399c0ce0a3_p2" target="shh1_s_shh2_s273_shh1_shh2_csa29"> <start x="19682.96" y="4386.0"/> <end x="19691.0" y="4382.0"/> </arc> <arc class="consumption" id="cons_b269cf8c-3bc2-4e28-add1-a2315994dc5e" source="shh1_s_shh2_s245_shh1_shh2_sa213" target="pr_3504923d-fadb-4719-a447-3d4c62d1a560_p1"> <start x="18919.5" y="4614.0"/> <next x="19675.0" y="4441.0"/> <end x="19745.5" y="4410.7935"/> </arc> <arc class="consumption" id="cons_ba7797dc-8584-42fc-b917-d45a098a60f9" source="shh1_s_shh2_s263_shh1_shh2_sa232" target="pr_3504923d-fadb-4719-a447-3d4c62d1a560_p1"> <start x="19634.5" y="4335.0"/> <next x="19675.0" y="4441.0"/> <end x="19745.5" y="4410.7935"/> </arc> <arc class="production" id="prod_30488f9f-b8b3-45ef-84b3-f0f5874b5c9d" source="pr_3504923d-fadb-4719-a447-3d4c62d1a560_p2" target="shh1_s_shh2_s274_shh1_shh2_csa30"> <start x="19775.5" y="4410.7935"/> <end x="19842.0" y="4382.0"/> </arc> <arc class="consumption" id="cons_f659ba47-2daf-4f19-a898-50f094d78c37" source="shh1_s_shh2_s279_shh1_shh2_sa243" target="pr_d713f6de-2e9f-4c58-94ad-5de6d4a4cbaa_p1"> <start x="19115.0" y="4633.0"/> <end x="19159.5" y="4592.956"/> </arc> <arc class="production" id="prod_5de358fc-183a-4539-bcb1-84589cc05ff3" source="pr_d713f6de-2e9f-4c58-94ad-5de6d4a4cbaa_p2" target="shh1_s_shh2_s280_shh1_shh2_sa244"> <start x="19189.5" y="4592.956"/> <end x="19234.0" y="4552.9126"/> </arc> <arc class="catalysis" id="modif_ddc967c5-95f0-4e33-8aca-76fc3ae9871d" source="shh1_s_shh2_s287_shh1_shh2_csa31" target="pr_d713f6de-2e9f-4c58-94ad-5de6d4a4cbaa"> <start x="19136.0" y="4712.0"/> <end x="19177.291" y="4597.104"/> </arc> <arc class="consumption" id="cons_9c871f8f-042f-49c3-9b9a-9a13cf6d2d30" source="shh1_s_shh2_s279_shh1_shh2_sa243" target="pr_78787fb8-149f-4afa-b4a1-a954454bc20a_p1"> <start x="19115.0" y="4633.0"/> <end x="19159.5" y="4609.4717"/> </arc> <arc class="production" id="prod_bf3acec7-e094-41cb-83eb-80f6323f444f" source="pr_78787fb8-149f-4afa-b4a1-a954454bc20a_p2" target="shh1_s_shh2_s281_shh1_shh2_sa245"> <start x="19189.5" y="4609.4717"/> <end x="19234.0" y="4585.943"/> </arc> <arc class="catalysis" id="modif_12bf4d77-fbff-460f-9a06-fc5a059bb6e4" source="shh1_s_shh2_s287_shh1_shh2_csa31" target="pr_78787fb8-149f-4afa-b4a1-a954454bc20a"> <start x="19136.0" y="4712.0"/> <end x="19176.338" y="4614.121"/> </arc> <arc class="consumption" id="cons_2d332dda-ee2d-4c0c-9abf-702bacfe07a1" source="shh1_s_shh2_s279_shh1_shh2_sa243" target="pr_6aec4a6a-bd13-4287-a44e-da7ffb0d7002_p1"> <start x="19115.0" y="4633.0"/> <end x="19159.5" y="4625.9863"/> </arc> <arc class="production" id="prod_225ac32b-08ff-4b7f-a973-102b616ee5fa" source="pr_6aec4a6a-bd13-4287-a44e-da7ffb0d7002_p2" target="shh1_s_shh2_s282_shh1_shh2_sa246"> <start x="19189.5" y="4625.9863"/> <end x="19234.0" y="4618.973"/> </arc> <arc class="catalysis" id="modif_4885634a-6db2-495a-aedb-a12129bce4b3" source="shh1_s_shh2_s287_shh1_shh2_csa31" target="pr_6aec4a6a-bd13-4287-a44e-da7ffb0d7002"> <start x="19136.0" y="4712.0"/> <end x="19175.086" y="4630.952"/> </arc> <arc class="consumption" id="cons_3164e11a-6aaf-4296-95ec-7d86d4ada998" source="shh1_s_shh2_s279_shh1_shh2_sa243" target="pr_482d1a53-1550-45f2-8c2e-96b6052037c1_p1"> <start x="19115.0" y="4633.0"/> <end x="19159.5" y="4642.502"/> </arc> <arc class="production" id="prod_16239142-f56e-4c4c-8d0a-b162d6120bcc" source="pr_482d1a53-1550-45f2-8c2e-96b6052037c1_p2" target="shh1_s_shh2_s283_shh1_shh2_sa247"> <start x="19189.5" y="4642.502"/> <end x="19234.0" y="4652.004"/> </arc> <arc class="catalysis" id="modif_e3886cea-48ca-4181-ad70-095dcac92338" source="shh1_s_shh2_s287_shh1_shh2_csa31" target="pr_482d1a53-1550-45f2-8c2e-96b6052037c1"> <start x="19136.0" y="4712.0"/> <end x="19173.71" y="4647.4395"/> </arc> <arc class="consumption" id="cons_4011f933-3c74-4b94-8844-a57657982b6a" source="shh1_s_shh2_s279_shh1_shh2_sa243" target="pr_14aded83-025e-47cd-8c2d-74d8b5694e85_p1"> <start x="19115.0" y="4633.0"/> <end x="19159.5" y="4659.017"/> </arc> <arc class="production" id="prod_7c9db805-2572-46ac-9036-49efcbe6ee9e" source="pr_14aded83-025e-47cd-8c2d-74d8b5694e85_p2" target="shh1_s_shh2_s284_shh1_shh2_sa248"> <start x="19189.5" y="4659.017"/> <end x="19234.0" y="4685.034"/> </arc> <arc class="catalysis" id="modif_df03c279-9b0b-4b5b-b003-772ff769954d" source="shh1_s_shh2_s287_shh1_shh2_csa31" target="pr_14aded83-025e-47cd-8c2d-74d8b5694e85"> <start x="19136.0" y="4712.0"/> <end x="19172.496" y="4663.598"/> </arc> <arc class="consumption" id="cons_caef8867-636f-425d-9b97-9e9c1b31099a" source="shh1_s_shh2_s279_shh1_shh2_sa243" target="pr_346754b9-3c38-47da-aad4-1729147a7eb7_p1"> <start x="19115.0" y="4633.0"/> <end x="19159.5" y="4675.532"/> </arc> <arc class="production" id="prod_47a4eac5-63dd-40f4-b034-fc4b2f2a0eca" source="pr_346754b9-3c38-47da-aad4-1729147a7eb7_p2" target="shh1_s_shh2_s285_shh1_shh2_sa249"> <start x="19189.5" y="4675.532"/> <end x="19234.0" y="4718.0645"/> </arc> <arc class="catalysis" id="modif_2c4444cd-f42c-438e-9ba0-0186bbc3ce73" source="shh1_s_shh2_s287_shh1_shh2_csa31" target="pr_346754b9-3c38-47da-aad4-1729147a7eb7"> <start x="19136.0" y="4712.0"/> <end x="19171.592" y="4679.5996"/> </arc> <arc class="consumption" id="cons_ee31083e-c3da-42eb-bcac-7095f6bab853" source="shh1_s_shh2_s128_shh1_shh2_sa116" target="pr_e34591b1-e771-4699-88b6-67dd12c29b26_p1"> <start x="18931.0" y="4115.9434"/> <end x="18989.0" y="4138.9717"/> </arc> <arc class="production" id="prod_e32a923e-0294-4913-80e2-5bfb12a89980" source="pr_e34591b1-e771-4699-88b6-67dd12c29b26_p2" target="shh1_s_shh2_s286_shh1_shh2_sa250"> <start x="19019.0" y="4138.9717"/> <end x="19077.0" y="4162.0"/> </arc> <arc class="consumption" id="cons_2c44dd20-dbcc-4a1f-8d12-954369bc68e9" source="shh1_s_shh2_s14_shh1_shh2_sa11" target="pr_a75e1010-834d-4dee-93ed-886036bce118_p1"> <start x="18345.0" y="3222.0"/> <next x="18974.5" y="4714.0"/> <end x="18991.25" y="4712.9326"/> </arc> <arc class="consumption" id="cons_f4df0407-8639-4201-878f-585732b1a4bf" source="shh1_s_shh2_s286_shh1_shh2_sa250" target="pr_a75e1010-834d-4dee-93ed-886036bce118_p1"> <start x="19117.0" y="4182.0"/> <next x="18974.5" y="4714.0"/> <end x="18991.25" y="4712.9326"/> </arc> <arc class="production" id="prod_784047da-f5de-4205-8482-ae4aa2d7616c" source="pr_a75e1010-834d-4dee-93ed-886036bce118_p2" target="shh1_s_shh2_s287_shh1_shh2_csa31"> <start x="19021.25" y="4712.9326"/> <end x="19034.0" y="4712.0"/> </arc> <arc class="consumption" id="cons_7e16f967-155a-4180-9712-340a33513f0f" source="shh1_s_shh2_s279_shh1_shh2_sa243" target="pr_eb9c7747-8f52-4ca1-b4f7-f8d7c1a9d715_p1"> <start x="19115.0" y="4633.0"/> <end x="19159.5" y="4576.4414"/> </arc> <arc class="production" id="prod_ae2ec08d-41bf-49ff-a56d-5229c153ff52" source="pr_eb9c7747-8f52-4ca1-b4f7-f8d7c1a9d715_p2" target="shh1_s_shh2_s290_shh1_shh2_sa253"> <start x="19189.5" y="4576.4414"/> <end x="19234.0" y="4519.8823"/> </arc> <arc class="catalysis" id="modif_71734bb5-efeb-43cb-bd4d-bf8d8c85d212" source="shh1_s_shh2_s287_shh1_shh2_csa31" target="pr_eb9c7747-8f52-4ca1-b4f7-f8d7c1a9d715"> <start x="19136.0" y="4712.0"/> <end x="19177.945" y="4580.0654"/> </arc> <arc class="consumption" id="cons_3f4fcd9c-45aa-4c1c-952b-8add6cb78f3c" source="shh1_s_shh2_s290_shh1_shh2_sa253" target="pr_5d1f28cb-53b3-47a2-9c7e-8a94182a8cf6_p1"> <start x="19311.5" y="4508.0"/> <next x="19818.5" y="4378.5"/> <end x="19888.25" y="4380.292"/> </arc> <arc class="consumption" id="cons_0c1232dc-814b-453a-8a2d-8b53ebb245d9" source="shh1_s_shh2_s291_shh1_shh2_sa254" target="pr_5d1f28cb-53b3-47a2-9c7e-8a94182a8cf6_p1"> <start x="19589.5" y="4380.5"/> <next x="19818.5" y="4378.5"/> <end x="19888.25" y="4380.292"/> </arc> <arc class="production" id="prod_b0f11885-69d1-4804-a464-0cc062d9aaf1" source="pr_5d1f28cb-53b3-47a2-9c7e-8a94182a8cf6_p2" target="shh1_s_shh2_s295_shh1_shh2_csa32"> <start x="19918.25" y="4380.292"/> <end x="19984.0" y="4382.0"/> </arc> <arc class="consumption" id="cons_e6860f71-1ca7-4314-9165-5fcbb9753edc" source="shh1_s_shh2_s280_shh1_shh2_sa244" target="pr_13d1cb77-7dad-4398-827f-09acd1ec9102_p1"> <start x="19311.5" y="4544.5"/> <next x="19663.0" y="4503.0"/> <end x="19662.5" y="4515.1797"/> </arc> <arc class="consumption" id="cons_27733d9e-66c7-4b70-b06b-91f6631bff66" source="shh1_s_shh2_s259_shh1_shh2_sa257" target="pr_13d1cb77-7dad-4398-827f-09acd1ec9102_p1"> <start x="19629.5" y="4404.0"/> <next x="19663.0" y="4503.0"/> <end x="19662.5" y="4515.1797"/> </arc> <arc class="production" id="prod_6b48e47c-9c95-490e-ad78-05ca87afa10d" source="pr_13d1cb77-7dad-4398-827f-09acd1ec9102_p2" target="shh1_s_shh2_s296_shh1_shh2_csa33"> <start x="19692.5" y="4515.1797"/> <end x="19688.0" y="4524.0"/> </arc> <arc class="consumption" id="cons_dd965757-7b3f-4f8c-b435-695e7f97c89b" source="shh1_s_shh2_s301_shh1_shh2_sa261" target="pr_47a901ad-b5f1-4bb4-af06-45dd1da63412_p1"> <start x="19609.5" y="4472.5"/> <end x="19396.281" y="4090.75"/> </arc> <arc class="production" id="prod_c1e36ba2-efee-460d-ab08-6e24f2059e1e" source="pr_47a901ad-b5f1-4bb4-af06-45dd1da63412_p2" target="shh1_s_shh2_s299_shh1_shh2_sa145"> <start x="19396.281" y="4060.75"/> <end x="19183.06" y="3679.0"/> </arc> <arc class="consumption" id="cons_732620ff-0be7-4ea7-bb66-1cb66c46fbf0" source="shh1_s_shh2_s300_shh1_shh2_sa260" target="pr_634e426b-bf41-4646-b7a8-f1f328b6f2ac_p1"> <start x="19609.5" y="4436.5"/> <end x="19396.469" y="4072.75"/> </arc> <arc class="production" id="prod_6b696064-3a72-498a-b823-5065b284a6cb" source="pr_634e426b-bf41-4646-b7a8-f1f328b6f2ac_p2" target="shh1_s_shh2_s299_shh1_shh2_sa145"> <start x="19396.469" y="4042.75"/> <end x="19183.438" y="3679.0"/> </arc> <arc class="consumption" id="cons_71e0434f-5e1c-4386-85cd-ccd408f5540e" source="shh1_s_shh2_s290_shh1_shh2_sa253" target="pr_5a529b96-19d9-4e79-a617-24d2f3c5ba4c_p1"> <start x="19279.0" y="4508.0"/> <next x="19668.0" y="4481.0"/> <end x="19741.0" y="4503.0"/> </arc> <arc class="consumption" id="cons_050a8e10-4b71-47b7-8ee9-9e51dacf8211" source="shh1_s_shh2_s300_shh1_shh2_sa260" target="pr_5a529b96-19d9-4e79-a617-24d2f3c5ba4c_p1"> <start x="19629.5" y="4449.0"/> <next x="19668.0" y="4481.0"/> <end x="19741.0" y="4503.0"/> </arc> <arc class="production" id="prod_99b02f3e-1ac1-47a0-93e7-569e4d77f33a" source="pr_5a529b96-19d9-4e79-a617-24d2f3c5ba4c_p2" target="shh1_s_shh2_s302_shh1_shh2_csa34"> <start x="19771.0" y="4503.0"/> <end x="19840.0" y="4524.0"/> </arc> <arc class="consumption" id="cons_9ac63a44-e459-4a98-98a3-ca4f287fd9e9" source="shh1_s_shh2_s280_shh1_shh2_sa244" target="pr_689ca8f0-3a90-4b84-9e85-1708dd393712_p1"> <start x="19310.162" y="4532.0"/> <end x="19244.383" y="3932.0"/> </arc> <arc class="production" id="prod_4000504c-3d1b-47cb-9fdb-ffea49ea4463" source="pr_689ca8f0-3a90-4b84-9e85-1708dd393712_p2" target="shh1_s_shh2_s53_shh1_shh2_sa47"> <start x="19244.383" y="3902.0"/> <end x="19178.604" y="3302.0"/> </arc> <arc class="consumption" id="cons_b115af6b-14bf-4c39-bc9e-b7cb9cc1fbaf" source="shh1_s_shh2_s280_shh1_shh2_sa244" target="pr_305b3b2b-fc40-47a8-a931-5cad5e89d1ad_p1"> <start x="19311.5" y="4544.5"/> <next x="19534.0" y="4558.5"/> <end x="19746.0" y="4541.0967"/> </arc> <arc class="consumption" id="cons_1ae8c0b6-42a9-42c1-9c69-249d1a47e154" source="shh1_s_shh2_s305_shh1_shh2_sa264" target="pr_305b3b2b-fc40-47a8-a931-5cad5e89d1ad_p1"> <start x="19629.5" y="4524.0"/> <next x="19534.0" y="4558.5"/> <end x="19746.0" y="4541.0967"/> </arc> <arc class="production" id="prod_d8d42dd3-f752-40c5-a7ba-a2252913c39b" source="pr_305b3b2b-fc40-47a8-a931-5cad5e89d1ad_p2" target="shh1_s_shh2_s306_shh1_shh2_csa35"> <start x="19776.0" y="4541.0967"/> <end x="19984.0" y="4524.0"/> </arc> <arc class="consumption" id="cons_addad039-d09b-4209-8f11-4012f8f13989" source="shh1_s_shh2_s281_shh1_shh2_sa245" target="pr_ac9b15e4-6def-4034-9c73-f402054efe90_p1"> <start x="19311.5" y="4581.0"/> <next x="19663.0" y="4625.5"/> <end x="19676.49" y="4637.75"/> </arc> <arc class="consumption" id="cons_01676084-977e-4b55-aa52-f043c9aa8705" source="shh1_s_shh2_s305_shh1_shh2_sa264" target="pr_ac9b15e4-6def-4034-9c73-f402054efe90_p1"> <start x="19629.5" y="4524.0"/> <next x="19663.0" y="4625.5"/> <end x="19676.49" y="4637.75"/> </arc> <arc class="production" id="prod_d279e626-6d46-4c3e-b318-8b416d8c4cb7" source="pr_ac9b15e4-6def-4034-9c73-f402054efe90_p2" target="shh1_s_shh2_s309_shh1_shh2_csa36"> <start x="19676.49" y="4667.75"/> <end x="19688.0" y="4676.0"/> </arc> <arc class="consumption" id="cons_c73569d6-50b2-49df-b573-d9d5b66a364e" source="shh1_s_shh2_s280_shh1_shh2_sa244" target="pr_9e7a91c8-9395-4c72-98f3-08ed75048192_p1"> <start x="19311.5" y="4544.5"/> <next x="19707.0" y="4602.5"/> <end x="19760.5" y="4640.3555"/> </arc> <arc class="consumption" id="cons_a75705ac-74c6-4be7-9180-a4b065fcf712" source="shh1_s_shh2_s71_shh1_shh2_sa273" target="pr_9e7a91c8-9395-4c72-98f3-08ed75048192_p1"> <start x="19629.5" y="4564.5"/> <next x="19707.0" y="4602.5"/> <end x="19760.5" y="4640.3555"/> </arc> <arc class="production" id="prod_8f88b617-c9fd-403e-b573-987c3ef4991f" source="pr_9e7a91c8-9395-4c72-98f3-08ed75048192_p2" target="shh1_s_shh2_s312_shh1_shh2_csa37"> <start x="19790.5" y="4640.3555"/> <end x="19840.0" y="4676.0"/> </arc> <arc class="consumption" id="cons_db415e45-800e-4e26-aa94-b91238942db3" source="shh1_s_shh2_s281_shh1_shh2_sa245" target="pr_011f1e98-aca5-4ef0-8ad7-ea73a6f3afb2_p1"> <start x="19311.5" y="4581.0"/> <next x="19473.0" y="4580.5"/> <end x="19715.5" y="4628.624"/> </arc> <arc class="consumption" id="cons_d3f683ef-77c7-4256-9970-68b73d4bb4c7" source="shh1_s_shh2_s71_shh1_shh2_sa273" target="pr_011f1e98-aca5-4ef0-8ad7-ea73a6f3afb2_p1"> <start x="19629.5" y="4564.5"/> <next x="19473.0" y="4580.5"/> <end x="19715.5" y="4628.624"/> </arc> <arc class="production" id="prod_2f072526-ef9d-4d4b-a498-fc34c58815f7" source="pr_011f1e98-aca5-4ef0-8ad7-ea73a6f3afb2_p2" target="shh1_s_shh2_s313_shh1_shh2_csa38"> <start x="19745.5" y="4628.624"/> <end x="19984.0" y="4676.0"/> </arc> <arc class="consumption" id="cons_d676eb54-659a-471e-b1ac-fe84845d45ab" source="shh1_s_shh2_s283_shh1_shh2_sa247" target="pr_372fdf91-86df-42d4-aea8-341ef2b1397e_p1"> <start x="19311.5" y="4654.0"/> <next x="19653.0" y="4607.5"/> <end x="19887.32" y="4365.25"/> </arc> <arc class="consumption" id="cons_88d0efe5-e038-4520-b7da-f4dd47b3c811" source="shh1_s_shh2_s318_shh1_shh2_sa274" target="pr_372fdf91-86df-42d4-aea8-341ef2b1397e_p1"> <start x="19623.5" y="4608.0"/> <next x="19653.0" y="4607.5"/> <end x="19887.32" y="4365.25"/> </arc> <arc class="production" id="prod_29e5c5ea-8694-4ce2-a3d3-8d8a0c735d24" source="pr_372fdf91-86df-42d4-aea8-341ef2b1397e_p2" target="shh1_s_shh2_s319_shh1_shh2_csa39"> <start x="19887.32" y="4335.25"/> <end x="20118.0" y="4097.0"/> </arc> <arc class="consumption" id="cons_b5ef6791-e23d-4369-a256-4f19b96b27d6" source="shh1_s_shh2_s282_shh1_shh2_sa246" target="pr_2a043391-0db5-4616-853a-fa4f7f008c9a_p1"> <start x="19311.5" y="4617.5"/> <next x="19957.0" y="4441.5"/> <end x="20039.6" y="4353.25"/> </arc> <arc class="consumption" id="cons_fdf763e7-486b-4768-b43d-c836e163437f" source="shh1_s_shh2_s322_shh1_shh2_sa277" target="pr_2a043391-0db5-4616-853a-fa4f7f008c9a_p1"> <start x="19623.5" y="4641.0"/> <next x="19957.0" y="4441.5"/> <end x="20039.6" y="4353.25"/> </arc> <arc class="production" id="prod_add3a84d-fb56-43fa-98a0-e8abee7f3c63" source="pr_2a043391-0db5-4616-853a-fa4f7f008c9a_p2" target="shh1_s_shh2_s323_shh1_shh2_csa40"> <start x="20039.6" y="4323.25"/> <end x="20119.0" y="4239.0"/> </arc> <arc class="consumption" id="cons_a76d4684-cc63-413e-95f6-60a5f0e0387e" source="shh1_s_shh2_s245_shh1_shh2_sa213" target="pr_5f089ed4-f56e-4711-81cd-050936cf0702_p1"> <start x="18919.5" y="4614.0"/> <next x="19581.5" y="4096.0"/> <end x="19623.25" y="4096.0"/> </arc> <arc class="consumption" id="cons_db3eb225-c207-40ef-8aa8-30a3b7109bcb" source="shh1_s_shh2_s258_shh1_shh2_sa227" target="pr_5f089ed4-f56e-4711-81cd-050936cf0702_p1"> <start x="19581.5" y="4007.5"/> <next x="19581.5" y="4096.0"/> <end x="19623.25" y="4096.0"/> </arc> <arc class="production" id="prod_2a1727f9-8ea9-49de-b6f1-95faea064862" source="pr_5f089ed4-f56e-4711-81cd-050936cf0702_p2" target="shh1_s_shh2_s250_shh1_shh2_csa25"> <start x="19653.25" y="4096.0"/> <end x="19691.0" y="4096.0"/> </arc> <arc class="consumption" id="cons_5cad9827-d103-40f8-ab5a-6a06826bebab" source="shh1_s_shh2_s198_shh1_shh2_sa217" target="pr_c383ed1e-d4d9-4005-8a89-fe7def6798b5_p1"> <start x="18919.5" y="4658.0"/> <next x="19653.0" y="4657.5"/> <end x="19874.0" y="4518.5728"/> </arc> <arc class="consumption" id="cons_9eedb5b0-2f3e-455d-b873-317781b09fb0" source="shh1_s_shh2_s326_shh1_shh2_sa280" target="pr_c383ed1e-d4d9-4005-8a89-fe7def6798b5_p1"> <start x="19623.5" y="4681.0"/> <next x="19653.0" y="4657.5"/> <end x="19874.0" y="4518.5728"/> </arc> <arc class="production" id="prod_c53cfdbe-6a7d-46b4-b0ff-5f71a0875eca" source="pr_c383ed1e-d4d9-4005-8a89-fe7def6798b5_p2" target="shh1_s_shh2_s328_shh1_shh2_csa41"> <start x="19904.0" y="4518.5728"/> <end x="20121.0" y="4382.0"/> </arc> <arc class="consumption" id="cons_ddc2e8d3-9bd3-4c2b-af50-bdbe7dcaa58b" source="shh1_s_shh2_s198_shh1_shh2_sa217" target="pr_b90f09d7-3045-4023-9160-005859356332_p1"> <start x="18919.5" y="4658.0"/> <next x="19653.0" y="4657.5"/> <end x="19870.5" y="4590.171"/> </arc> <arc class="consumption" id="cons_87f1b9c0-b927-445b-b7bd-e448feef62d6" source="shh1_s_shh2_s327_shh1_shh2_sa281" target="pr_b90f09d7-3045-4023-9160-005859356332_p1"> <start x="19623.5" y="4719.0"/> <next x="19653.0" y="4657.5"/> <end x="19870.5" y="4590.171"/> </arc> <arc class="production" id="prod_d1337160-d1bc-438f-8dae-02f2337adafa" source="pr_b90f09d7-3045-4023-9160-005859356332_p2" target="shh1_s677_shh1_shh2_csa42"> <start x="19900.5" y="4590.171"/> <end x="20114.0" y="4524.0"/> </arc> <arc class="consumption" id="cons_972dbfd0-4419-4a5e-9a74-390cfeabaa1f" source="shh1_s_shh2_s126_shh1_shh2_sa114" target="pr_cdde13bd-7e3e-479d-9672-540fe71f9ac0_p1"> <start x="18931.0" y="4060.3743"/> <end x="19027.133" y="3983.687"/> </arc> <arc class="production" id="prod_ea1215bd-c217-4429-be06-d0b1c296b4d4" source="pr_cdde13bd-7e3e-479d-9672-540fe71f9ac0_p2" target="shh1_s_shh2_s334_shh1_shh2_sa286"> <start x="19057.133" y="3983.687"/> <end x="19153.264" y="3907.0"/> </arc> <arc class="consumption" id="cons_06f72977-812a-41ed-acc5-4540916e883d" source="shh1_s_shh2_s75_shh1_shh2_sa69" target="pr_f90fa37e-0f98-469c-b624-10dc89223257_p1"> <start x="18931.0" y="3658.9395"/> <end x="19030.148" y="3767.9697"/> </arc> <arc class="production" id="prod_4cdeec2f-b7bc-4861-a214-df216d57e012" source="pr_f90fa37e-0f98-469c-b624-10dc89223257_p2" target="shh1_s_shh2_s334_shh1_shh2_sa286"> <start x="19060.148" y="3767.9697"/> <end x="19159.297" y="3877.0"/> </arc> <arc class="consumption" id="cons_54b02d44-a319-42c2-80f8-be28eb3e0b5e" source="shh1_s_shh2_s84_shh1_shh2_sa78" target="pr_7f99bb79-35f9-46eb-b4c7-0af30bd9508a_p1"> <start x="18931.0" y="3737.8948"/> <end x="19026.125" y="3807.4473"/> </arc> <arc class="production" id="prod_841741a9-e506-4def-933c-a3c7b974d4bb" source="pr_7f99bb79-35f9-46eb-b4c7-0af30bd9508a_p2" target="shh1_s_shh2_s334_shh1_shh2_sa286"> <start x="19056.125" y="3807.4473"/> <end x="19151.25" y="3877.0"/> </arc> <arc class="consumption" id="cons_28a205fe-1a30-4efe-898a-1e2e65c6c901" source="shh1_s_shh2_s86_shh1_shh2_sa80" target="pr_874ef7ca-84da-4c76-a242-f307439e54c5_p1"> <start x="18931.0" y="3777.848"/> <end x="19021.969" y="3827.4238"/> </arc> <arc class="production" id="prod_c7fee2bc-b001-4187-92c8-f93645de6875" source="pr_874ef7ca-84da-4c76-a242-f307439e54c5_p2" target="shh1_s_shh2_s334_shh1_shh2_sa286"> <start x="19051.969" y="3827.4238"/> <end x="19142.938" y="3877.0"/> </arc> <arc class="consumption" id="cons_ff09f942-eaa5-4d23-925b-ec4d0f4a3f53" source="shh1_s_shh2_s186_shh1_shh2_sa166" target="pr_749ee755-f5ab-48f5-ae72-064c0b482a4f_p1"> <start x="18924.762" y="4391.5"/> <end x="19046.123" y="4164.25"/> </arc> <arc class="production" id="prod_5a35b085-365a-41c0-b83f-d812f5e8a201" source="pr_749ee755-f5ab-48f5-ae72-064c0b482a4f_p2" target="shh1_s_shh2_s334_shh1_shh2_sa286"> <start x="19046.123" y="4134.25"/> <end x="19167.484" y="3907.0"/> </arc> <arc class="consumption" id="cons_168900f5-be58-4af9-bdd0-44be52d3e4e8" source="shh1_s_shh3_s3_shh1_shh3_sa3" target="pr_23977a41-6725-485a-9361-1ad3ebf6e130_p1"> <start x="19484.0" y="4971.0"/> <next x="19510.646" y="4976.062"/> <end x="19484.324" y="4970.7754"/> </arc> <arc class="consumption" id="cons_bd7319ac-37ee-4224-b31f-b109c146cf17" source="shh1_s641_shh1_shh3_sa2" target="pr_23977a41-6725-485a-9361-1ad3ebf6e130_p1"> <start x="19583.0" y="4982.0"/> <next x="19510.646" y="4976.062"/> <end x="19484.324" y="4970.7754"/> </arc> <arc class="production" id="prod_980c6915-2d9c-4805-977c-5b679c13db91" source="pr_23977a41-6725-485a-9361-1ad3ebf6e130_p2" target="shh1_s_shh3_s6_shh1_shh3_csa1"> <start x="19454.324" y="4970.7754"/> <end x="19432.0" y="4966.0"/> </arc> <arc class="consumption" id="cons_297622d3-4fbf-4aef-8a7e-92575c41ba86" source="shh1_s_shh3_s138_shh1_shh3_csa4" target="pr_d01d05a2-c685-4ed9-a042-57da38f258de_p1"> <start x="19146.0" y="5048.0"/> <next x="19146.25" y="5099.0"/> <end x="19074.375" y="5075.586"/> </arc> <arc class="consumption" id="cons_634d64cb-4b39-4c9b-8323-7cc9e77990f7" source="shh1_s_shh3_s6_shh1_shh3_csa1" target="pr_d01d05a2-c685-4ed9-a042-57da38f258de_p1"> <start x="19328.0" y="4966.0"/> <next x="19146.25" y="5099.0"/> <end x="19074.375" y="5075.586"/> </arc> <arc class="production" id="prod_938ea5b2-0d66-4210-ad21-f3510f19a76f" source="pr_d01d05a2-c685-4ed9-a042-57da38f258de_p2" target="shh1_s680_shh1_shh3_csa2"> <start x="19044.375" y="5075.586"/> <end x="18976.5" y="5053.25"/> </arc> <arc class="consumption" id="cons_36b578e8-c340-445f-8244-c512252a44c7" source="shh1_s680_shh1_shh3_csa2" target="pr_b93e1f1d-7a92-424d-a1ad-1cd2a064fbc3_p1"> <start x="18636.5" y="5008.5"/> <next x="18603.0" y="5007.5"/> <end x="18579.75" y="5007.7637"/> </arc> <arc class="consumption" id="cons_866593d6-23b0-4e94-8b13-a55ef02199ac" source="shh1_s_shh1_s583_shh1_shh3_sa35" target="pr_b93e1f1d-7a92-424d-a1ad-1cd2a064fbc3_p1"> <start x="18564.0" y="5168.5"/> <next x="18603.0" y="5007.5"/> <end x="18579.75" y="5007.7637"/> </arc> <arc class="production" id="prod_ad43054b-fac1-41eb-b44d-12e7c533b838" source="pr_b93e1f1d-7a92-424d-a1ad-1cd2a064fbc3_p2" target="shh1_s_shh3_s16_shh1_shh3_csa5"> <start x="18549.75" y="5007.7637"/> <end x="18530.5" y="5008.0"/> </arc> <arc class="production" id="addprod_1ff062fd-ffb1-4421-b11a-c604740d22f3" source="pr_b93e1f1d-7a92-424d-a1ad-1cd2a064fbc3_p2" target="shh1_s_shh1_s584_shh1_shh3_sa36"> <start x="18549.75" y="5007.7637"/> <end x="18467.492" y="5167.5"/> </arc> <arc class="consumption" id="cons_8ae49084-df52-47a2-9120-4fe90baa0717" source="shh1_s_shh3_s16_shh1_shh3_csa5" target="pr_c083e9de-8457-4150-9d04-77a23204d79e_p1"> <start x="18190.5" y="5008.0"/> <end x="18188.0" y="5007.327"/> </arc> <arc class="production" id="prod_018f63a7-0505-4845-b743-0c71b3723c2a" source="pr_c083e9de-8457-4150-9d04-77a23204d79e_p2" target="shh1_s641_shh1_shh3_sa38"> <start x="18158.0" y="5007.327"/> <next x="18155.5" y="5006.654"/> <end x="18099.5" y="4986.4"/> </arc> <arc class="production" id="prod_928fa6d3-c9c1-48c0-acb2-b1fc2c2d6404" source="pr_c083e9de-8457-4150-9d04-77a23204d79e_p2" target="shh1_s_shh3_s60_shh1_shh3_csa6"> <start x="18158.0" y="5007.327"/> <next x="18155.5" y="5006.654"/> <end x="18129.0" y="5182.0"/> </arc> <arc class="production" id="addprod_eb965870-6350-4812-938d-221f9e40b39b" source="pr_c083e9de-8457-4150-9d04-77a23204d79e_p2" target="shh1_s_shh3_s61_shh1_shh3_csa7"> <start x="18158.0" y="5007.327"/> <end x="18301.0" y="5182.0"/> </arc> <arc class="production" id="addprod_72d3cf08-14ef-4fa8-958e-bd4878e35dfe" source="pr_c083e9de-8457-4150-9d04-77a23204d79e_p2" target="shh1_s_shh1_s283_shh1_shh3_sa43"> <start x="18158.0" y="5007.327"/> <end x="18466.5" y="5221.0"/> </arc> <arc class="consumption" id="cons_c25acf51-33e1-46d9-a17a-f3fc68ae9c79" source="shh1_s_shh1_s285_shh1_shh3_sa47" target="pr_313e7707-5411-4756-8f16-3f876baa1a13_p1"> <start x="18420.0" y="5420.0"/> <next x="18436.25" y="5382.0"/> <end x="18457.625" y="5403.957"/> </arc> <arc class="consumption" id="cons_64b9e55e-50a7-4c90-a790-d1d59807163c" source="shh1_s_shh3_s61_shh1_shh3_csa7" target="pr_313e7707-5411-4756-8f16-3f876baa1a13_p1"> <start x="18301.0" y="5302.0"/> <next x="18436.25" y="5382.0"/> <end x="18457.625" y="5403.957"/> </arc> <arc class="production" id="prod_d4d036ce-21df-4c0f-a8c8-21275dbb10e6" source="pr_313e7707-5411-4756-8f16-3f876baa1a13_p2" target="shh1_s_shh3_s69_shh1_shh3_csa8"> <start x="18487.625" y="5403.957"/> <end x="18505.0" y="5423.5"/> </arc> <arc class="consumption" id="cons_48c6d76c-34e2-4ff6-8f22-3ff15490f01d" source="shh1_s_shh1_s283_shh1_shh3_sa43" target="pr_3f59d7a6-88ef-4660-905c-3d790687e25f_p1"> <start x="18506.5" y="5241.0"/> <end x="18540.5" y="5241.0"/> </arc> <arc class="production" id="prod_fb5a8485-cfac-418c-a79d-efc8fdeb290b" source="pr_3f59d7a6-88ef-4660-905c-3d790687e25f_p2" target="shh1_s_shh3_s73_shh1_shh3_sa48"> <start x="18570.5" y="5241.0"/> <end x="18604.5" y="5241.0"/> </arc> <arc class="catalysis" id="modif_903f8985-bc59-49ec-9d5f-9372cb555930" source="shh1_s_shh3_s69_shh1_shh3_csa8" target="pr_3f59d7a6-88ef-4660-905c-3d790687e25f"> <start x="18556.5" y="5342.0"/> <end x="18555.5" y="5246.0"/> </arc> <arc class="consumption" id="cons_2f9c9129-9847-4e7c-b89d-922d1f307249" source="shh1_s_shh3_s73_shh1_shh3_sa48" target="pr_6b809c2e-f202-4353-9b25-3b32be7f7d35_p1"> <start x="18684.5" y="5241.0"/> <end x="18721.25" y="5240.6396"/> </arc> <arc class="production" id="prod_2a8bef4f-1709-48ad-85fa-379d330b8826" source="pr_6b809c2e-f202-4353-9b25-3b32be7f7d35_p2" target="shh1_s_shh3_s77_shh1_shh3_sa51"> <start x="18751.25" y="5240.6396"/> <end x="18788.0" y="5240.279"/> </arc> <arc class="consumption" id="cons_bfad9115-c910-4318-b276-c3a43fa25fa7" source="shh1_s_shh3_s61_shh1_shh3_csa7" target="pr_744eae91-b45a-4a6c-8678-29614c41e3b0_p1"> <start x="18301.0" y="5302.0"/> <next x="18336.0" y="5496.0"/> <end x="18432.5" y="5557.3506"/> </arc> <arc class="consumption" id="cons_17010e02-5f9b-491b-beb1-fb4504078986" source="shh1_s_shh3_s136_shh1_shh3_csa9" target="pr_744eae91-b45a-4a6c-8678-29614c41e3b0_p1"> <start x="18347.0" y="5555.0"/> <next x="18336.0" y="5496.0"/> <end x="18432.5" y="5557.3506"/> </arc> <arc class="production" id="prod_f6d2e282-6b10-4e4b-ada9-8207b5e0d32b" source="pr_744eae91-b45a-4a6c-8678-29614c41e3b0_p2" target="shh1_s_shh3_s134_shh1_shh3_csa10"> <start x="18462.5" y="5557.3506"/> <end x="18555.0" y="5616.5"/> </arc> <arc class="consumption" id="cons_22c3d6d9-e728-4ebe-a9cd-06b6bd1217f7" source="shh1_s_shh3_s134_shh1_shh3_csa10" target="pr_d6de48b8-dc45-4687-9157-a9e1c5520cb1_p1"> <start x="18739.0" y="5616.5"/> <end x="18782.0" y="5616.6855"/> </arc> <arc class="production" id="prod_dc2cf18b-30f6-49f0-a539-a48b43a809b7" source="pr_d6de48b8-dc45-4687-9157-a9e1c5520cb1_p2" target="shh1_s_shh1_s517_shh1_shh3_sa56"> <start x="18812.0" y="5616.6855"/> <end x="18855.0" y="5616.8716"/> </arc> <arc class="consumption" id="cons_6c568956-7364-4a8c-82e2-5978de6fc672" source="shh1_s_shh3_s86_shh1_shh3_sa59" target="pr_44bba7c2-08b3-42c1-8f47-90f396484ab6_p1"> <start x="19359.5" y="5433.0"/> <end x="19379.5" y="5434.5"/> </arc> <arc class="production" id="prod_68ef5eb8-e91c-4e06-972a-f4d049405243" source="pr_44bba7c2-08b3-42c1-8f47-90f396484ab6_p2" target="shh1_s_shh3_s88_shh1_shh3_sa60"> <start x="19409.5" y="5434.5"/> <end x="19429.5" y="5436.0"/> </arc> <arc class="consumption" id="cons_41513dc7-80f1-444f-a52c-14bbad48cf06" source="shh1_s642_shh1_shh3_sa57" target="pr_082b59d3-afc7-4786-bf66-6fa14e5103d9_p1"> <start x="18997.0" y="5433.0"/> <end x="19038.25" y="5433.0"/> </arc> <arc class="production" id="prod_8deb4c40-4c7b-469c-928a-600a69872b79" source="pr_082b59d3-afc7-4786-bf66-6fa14e5103d9_p2" target="shh1_s642_shh1_shh3_sa58"> <start x="19068.25" y="5433.0"/> <end x="19109.5" y="5433.0"/> </arc> <arc class="catalysis" id="modif_c4c0cac7-bced-45e3-a960-fe35c32edce9" source="shh1_s_shh3_s73_shh1_shh3_sa48" target="pr_082b59d3-afc7-4786-bf66-6fa14e5103d9"> <start x="18684.5" y="5259.3"/> <end x="19053.25" y="5428.0"/> </arc> <arc class="consumption" id="cons_6684e30a-69f6-4ad7-99c1-d535560923e4" source="shh1_s642_shh1_shh3_sa58" target="pr_6c4a9b18-f1da-46a3-b05d-dc20d5bf2f89_p1"> <start x="19189.5" y="5433.0"/> <end x="19219.5" y="5433.0"/> </arc> <arc class="production" id="prod_56ea3736-1e1a-47ae-aa7f-1c25f9b678d1" source="pr_6c4a9b18-f1da-46a3-b05d-dc20d5bf2f89_p2" target="shh1_s_shh3_s86_shh1_shh3_sa59"> <start x="19249.5" y="5433.0"/> <end x="19279.5" y="5433.0"/> </arc> <arc class="catalysis" id="modif_c65dbf22-ba90-43a7-baf7-eb11b2ab00cd" source="shh1_s642_shh1_shh3_sa58" target="pr_6c4a9b18-f1da-46a3-b05d-dc20d5bf2f89"> <start x="19149.5" y="5413.0"/> <next x="19149.502" y="5395.9995"/> <next x="19234.504" y="5396.0093"/> <end x="19234.5" y="5428.0"/> </arc> <arc class="consumption" id="cons_8bbf4185-0680-45de-9f6c-39cd71c78f56" source="shh1_s_shh3_s88_shh1_shh3_sa60" target="pr_00e118bb-5cfc-4e9b-b16f-b68c72c8becd_p1"> <start x="19472.5" y="5459.0"/> <next x="19556.5" y="5480.0"/> <end x="19556.5" y="5528.5"/> </arc> <arc class="consumption" id="cons_30a73625-c264-4a3f-8236-4eed34d0c9cf" source="shh1_s_shh3_s135_shh1_shh3_csa11" target="pr_00e118bb-5cfc-4e9b-b16f-b68c72c8becd_p1"> <start x="19625.0" y="5470.0"/> <next x="19556.5" y="5480.0"/> <end x="19556.5" y="5528.5"/> </arc> <arc class="production" id="prod_905ee8f1-510a-4f8b-8bfb-cc79594adf34" source="pr_00e118bb-5cfc-4e9b-b16f-b68c72c8becd_p2" target="shh1_s_shh3_s94_shh1_shh3_csa12"> <start x="19556.5" y="5558.5"/> <end x="19556.5" y="5603.0"/> </arc> <arc class="consumption" id="cons_248abc8b-3b2c-4cc1-8333-d9fe12541099" source="shh1_s_shh3_s94_shh1_shh3_csa12" target="pr_3d91d1d6-77ee-439e-9767-0e8e71fe8e9f_p1"> <start x="19505.0" y="5682.5"/> <end x="19235.0" y="5651.8975"/> </arc> <arc class="production" id="prod_421b90a3-de71-4c70-a016-398a7b50c0bb" source="pr_3d91d1d6-77ee-439e-9767-0e8e71fe8e9f_p2" target="shh1_s_shh1_s517_shh1_shh3_sa56"> <start x="19205.0" y="5651.8975"/> <end x="18935.0" y="5621.295"/> </arc> <arc class="consumption" id="cons_40b30e3e-f1c7-4cbb-b5c6-d6d8f10dd009" source="shh1_s_shh1_s517_shh1_shh3_sa56" target="pr_37e34648-d84c-4bc5-8519-02b2e491ecbd_p1"> <start x="18920.047" y="5602.0"/> <end x="19425.588" y="5290.25"/> </arc> <arc class="production" id="prod_2625b1d8-e42b-4192-bae0-08165015a21a" source="pr_37e34648-d84c-4bc5-8519-02b2e491ecbd_p2" target="shh1_s_shh3_s97_shh1_shh3_sa67"> <start x="19455.588" y="5290.25"/> <end x="19961.129" y="4978.5"/> </arc> <arc class="consumption" id="cons_a2e33f26-1d25-453b-abed-9ddc9fe0b84e" source="shh1_s_shh3_s97_shh1_shh3_sa67" target="pr_18ce24d3-0c52-48f3-ab87-e598e7fbfc6b_p1"> <start x="19982.0" y="4966.0"/> <next x="19980.0" y="4999.0"/> <end x="20000.0" y="4999.0"/> </arc> <arc class="consumption" id="cons_46e76f99-e3b3-447f-add1-432c83a4aef7" source="shh1_s_shh3_s98_shh1_shh3_sa68" target="pr_18ce24d3-0c52-48f3-ab87-e598e7fbfc6b_p1"> <start x="19981.0" y="5026.0"/> <next x="19980.0" y="4999.0"/> <end x="20000.0" y="4999.0"/> </arc> <arc class="production" id="prod_88bc1686-abbd-47f7-90e1-e79903b85cd2" source="pr_18ce24d3-0c52-48f3-ab87-e598e7fbfc6b_p2" target="shh1_s_shh3_s99_shh1_shh3_csa13"> <start x="20030.0" y="4999.0"/> <end x="20046.0" y="4999.0"/> </arc> <arc class="consumption" id="cons_f03b6675-605a-4497-8c45-12a8f4bd7e44" source="shh1_s_shh3_s102_shh1_shh3_csa14" target="pr_80cedba2-d5ee-4347-a66f-5154e91ba2aa_p1"> <start x="20055.0" y="5248.0"/> <end x="20105.0" y="5248.0"/> </arc> <arc class="production" id="prod_89261f21-9f61-4a85-89c6-dbd3e2fa0e67" source="pr_80cedba2-d5ee-4347-a66f-5154e91ba2aa_p2" target="shh1_s_shh3_s132_shh1_shh3_csa15"> <start x="20135.0" y="5248.0"/> <end x="20185.0" y="5248.0"/> </arc> <arc class="catalysis" id="logicarc_a4c5f692-477b-4615-940c-6a48b155889a" source="logicglyph_7b7aada7-d30d-4bd2-820e-9739ccac78a3_p2" target="pr_80cedba2-d5ee-4347-a66f-5154e91ba2aa"> <start x="20108.0" y="5170.995"/> <end x="20120.0" y="5243.0"/> </arc> <arc class="logic arc" id="modif_e220a171-0e8b-40b0-8d22-3ce5136a2e6c" source="shh1_s_shh3_s99_shh1_shh3_csa13" target="logicglyph_7b7aada7-d30d-4bd2-820e-9739ccac78a3_p1"> <start x="20096.0" y="5059.0"/> <end x="20108.0" y="5130.995"/> </arc> <arc class="logic arc" id="modif_742b2995-347a-4782-856e-df3b6fc2dcbe" source="shh1_s_shh3_s114_shh1_shh3_csa16" target="logicglyph_7b7aada7-d30d-4bd2-820e-9739ccac78a3_p1"> <start x="20230.0" y="5059.0"/> <end x="20108.0" y="5130.995"/> </arc> <arc class="logic arc" id="modif_405b60a6-c977-4a16-9cea-cc88736dac0a" source="shh1_s644_shh1_shh3_sa85" target="logicglyph_7b7aada7-d30d-4bd2-820e-9739ccac78a3_p1"> <start x="20305.5" y="5128.5044"/> <end x="20108.0" y="5130.995"/> </arc> <arc class="logic arc" id="modif_353c700b-c771-4013-a512-6d46ea37b2c8" source="shh1_s_shh3_s119_shh1_shh3_sa88" target="logicglyph_7b7aada7-d30d-4bd2-820e-9739ccac78a3_p1"> <start x="19969.32" y="5376.0"/> <end x="20108.0" y="5130.995"/> </arc> <arc class="consumption" id="addreact_b9ed879d-1bd4-41f2-a03f-9c202a4066a7" source="shh1_s_shh1_s583_shh1_shh3_sa80" target="pr_80cedba2-d5ee-4347-a66f-5154e91ba2aa_p1"> <start x="20100.018" y="5317.0"/> <end x="20105.0" y="5248.0"/> </arc> <arc class="production" id="addprod_1ac5c5fa-9ecc-4f1c-8fba-a5e06251628c" source="pr_80cedba2-d5ee-4347-a66f-5154e91ba2aa_p2" target="shh1_s_shh1_s584_shh1_shh3_sa79"> <start x="20135.0" y="5248.0"/> <end x="20152.303" y="5317.0"/> </arc> <arc class="consumption" id="cons_ad67698b-c0dc-40b3-b753-f52a79f86899" source="shh1_s_shh3_s112_shh1_shh3_sa81" target="pr_39e3a870-ea5b-4024-874b-b18b73cf62b4_p1"> <start x="20344.5" y="4969.5"/> <next x="20344.5" y="4999.0"/> <end x="20325.25" y="4999.0"/> </arc> <arc class="consumption" id="cons_4e5fe540-8266-4dde-b247-7ee879b7f37c" source="shh1_s644_shh1_shh3_sa82" target="pr_39e3a870-ea5b-4024-874b-b18b73cf62b4_p1"> <start x="20345.5" y="5027.0"/> <next x="20344.5" y="4999.0"/> <end x="20325.25" y="4999.0"/> </arc> <arc class="production" id="prod_1acc462c-885b-429d-94be-32118d2c3260" source="pr_39e3a870-ea5b-4024-874b-b18b73cf62b4_p2" target="shh1_s_shh3_s114_shh1_shh3_csa16"> <start x="20295.25" y="4999.0"/> <end x="20280.0" y="4999.0"/> </arc> <arc class="consumption" id="cons_4f44e32b-7c1c-4312-9e63-738accdb5cba" source="shh1_s644_shh1_shh3_sa82" target="pr_c7b3db79-55a8-40b3-9101-dd2bc9c8acf6_p1"> <start x="20345.5" y="5047.0"/> <end x="20345.5" y="5062.5"/> </arc> <arc class="production" id="prod_2cc2c1ea-de45-4e79-b77b-8aca395e137c" source="pr_c7b3db79-55a8-40b3-9101-dd2bc9c8acf6_p2" target="shh1_s644_shh1_shh3_sa85"> <start x="20345.5" y="5092.5"/> <end x="20345.5" y="5108.0"/> </arc> <arc class="catalysis" id="modif_9a292c06-cb4d-4083-b016-4ce91aaebaaf" source="shh1_s_shh3_s134_shh1_shh3_csa10" target="pr_c7b3db79-55a8-40b3-9101-dd2bc9c8acf6"> <start x="18739.0" y="5616.5"/> <end x="20340.5" y="5077.5"/> </arc> <arc class="consumption" id="cons_34b6d620-adbc-46a6-a331-f51d1c598f14" source="shh1_s_shh3_s132_shh1_shh3_csa15" target="pr_1422d72d-f63d-46e4-9fd0-8f970732d245_p1"> <start x="20235.0" y="5308.0"/> <end x="20236.41" y="5410.0"/> </arc> <arc class="production" id="prod_a699412e-2923-4a21-afe7-c5c6a8c53d26" source="pr_1422d72d-f63d-46e4-9fd0-8f970732d245_p2" target="shh1_s_shh3_s117_shh1_shh3_sa86"> <start x="20236.41" y="5440.0"/> <end x="20237.818" y="5542.0"/> </arc> <arc class="consumption" id="cons_56cf625b-5bc9-400d-87a8-863ec8e27691" source="shh1_s_shh3_s118_shh1_shh3_sa87" target="pr_816af77c-d0c9-4146-8938-1ae195ecf885_p1"> <start x="19958.0" y="5459.0"/> <next x="19958.0" y="5448.0"/> <end x="19928.0" y="5448.0"/> </arc> <arc class="consumption" id="cons_d17778f4-b2cf-45fc-a7a7-6ededfd25b67" source="shh1_s_shh3_s119_shh1_shh3_sa88" target="pr_816af77c-d0c9-4146-8938-1ae195ecf885_p1"> <start x="19958.0" y="5416.0"/> <next x="19958.0" y="5448.0"/> <end x="19928.0" y="5448.0"/> </arc> <arc class="production" id="prod_7532cf4e-79d9-45dd-9dd7-f7db9a7a2e98" source="pr_816af77c-d0c9-4146-8938-1ae195ecf885_p2" target="shh1_s_shh3_s120_shh1_shh3_csa17"> <start x="19898.0" y="5448.0"/> <end x="19872.0" y="5448.0"/> </arc> <arc class="consumption" id="cons_439082f6-52d5-4e5a-9ffc-c51e7d98df0b" source="shh1_s_shh3_s120_shh1_shh3_csa17" target="pr_68f92fa3-b9a4-4b99-9789-085b7b739c91_p1"> <start x="19822.0" y="5508.0"/> <end x="19393.5" y="5562.5"/> </arc> <arc class="production" id="prod_fccd598d-d0d3-48f2-bb4b-435b07951482" source="pr_68f92fa3-b9a4-4b99-9789-085b7b739c91_p2" target="shh1_s_shh1_s517_shh1_shh3_sa56"> <start x="19363.5" y="5562.5"/> <end x="18935.0" y="5617.0"/> </arc> <arc class="consumption" id="cons_22cec48a-78a6-4681-84d4-7bf56ce2bf7e" source="shh1_s641_shh1_shh3_sa2" target="pr_d88f74b1-0a1f-4438-8e06-b9408a213559_p1"> <start x="19583.0" y="4982.0"/> <next x="19655.5" y="4982.0"/> <end x="19661.75" y="4982.0"/> </arc> <arc class="consumption" id="cons_f19af1a4-1155-4c7d-a932-3284058d1467" source="shh1_s_shh3_s125_shh1_shh3_sa96" target="pr_d88f74b1-0a1f-4438-8e06-b9408a213559_p1"> <start x="19583.5" y="5088.0"/> <next x="19655.5" y="4982.0"/> <end x="19661.75" y="4982.0"/> </arc> <arc class="production" id="prod_4520b107-8dd6-4930-82d5-ffb3d8393dfc" source="pr_d88f74b1-0a1f-4438-8e06-b9408a213559_p2" target="shh1_s_shh3_s137_shh1_shh3_csa18"> <start x="19691.75" y="4982.0"/> <end x="19694.0" y="4982.0"/> </arc> <arc class="consumption" id="addreact_5461a6ce-da00-40b6-82f6-ebfe423a225a" source="shh1_s_shh3_s126_shh1_shh3_sa97" target="pr_d88f74b1-0a1f-4438-8e06-b9408a213559_p1"> <start x="19595.719" y="5109.0"/> <end x="19661.75" y="4982.0"/> </arc> <arc class="consumption" id="addreact_0094dff2-3565-400d-b156-5582f8381f34" source="shh1_s_shh3_s127_shh1_shh3_sa98" target="pr_d88f74b1-0a1f-4438-8e06-b9408a213559_p1"> <start x="19593.053" y="5150.0"/> <end x="19661.75" y="4982.0"/> </arc> <arc class="consumption" id="cons_851979ae-779e-41cb-9f48-4e767fcd1c54" source="shh1_s662_shh1_shh1_csa37" target="pr_1d04d210-6b94-4672-a379-f2dfa2351348_p1"> <start x="18592.875" y="2044.0"/> <end x="18589.906" y="2053.8984"/> </arc> <arc class="production" id="prod_7f56ad8d-c868-49cf-99aa-200437d2c266" source="pr_1d04d210-6b94-4672-a379-f2dfa2351348_p2" target="shh1_s_shh2_s131_shh1_shh1_sa244"> <start x="18559.906" y="2053.8984"/> <next x="18556.938" y="2063.7966"/> <end x="18512.5" y="2050.0"/> </arc> <arc class="production" id="prod_3c388fd4-9230-4aaa-9bb4-9d11a88c7ed7" source="pr_1d04d210-6b94-4672-a379-f2dfa2351348_p2" target="shh1_s639_shh1_shh1_sa245"> <start x="18559.906" y="2053.8984"/> <next x="18556.938" y="2063.7966"/> <end x="18491.75" y="2114.0"/> </arc> <arc class="production" id="addprod_6ac53b43-7603-4a9e-a440-5f22fb8c77da" source="pr_1d04d210-6b94-4672-a379-f2dfa2351348_p2" target="shh1_s_shh1_s431_shh1_shh1_sa243"> <start x="18559.906" y="2053.8984"/> <end x="18519.75" y="2181.0"/> </arc> </map> </sbgn>